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Ankylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the sacroiliac joints and the spine. In patients with active disease, magnetic resonance imaging (MRI) of the spine shows areas of bone marrow edema, the histopathological equivalent of which is unknown. In this study we correlate inflammation in the spine of patients with AS as revealed by histological examination with bone marrow edema as detected by MRI. We have compared the histopathological findings of zygapophyseal joints from 8 patients with AS (age: 30 to 64, disease duration 7 to 33 years) undergoing spinal surgery with findings in MRI. For histopathological analysis, we quantified infiltrates of CD3+, CD4+ and CD8+ T cells as well as CD20+ B cells immunohistochemically. Bone marrow edema was evaluated in hematoxylin and eosin stained sections and quantified as the percentage of the bone marrow area involved. All patients with AS showed interstitial mononuclear cell infiltrates and various degrees of bone marrow edema (range from 10% to 60%) in histopathological analysis. However, in only three of eight patients histopathological inflammation and edema in the zygapophyseal joints correlated with bone marrow edema in zygapophyseal joints of the lumbar spine as detected by MRI. Interestingly, two of these patients showed the highest histological score for bone marrow edema (60%). This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI.
The prevalence of ankylosing spondylitis (AS) within Caucasians has been estimated to be between 0.2% and 0.8% [1,2]. About 20% of these patients with AS have bridging syndesmophytes which result in restricted movement of the spine as a consequence of active inflammation in spinal joints and adjacent structures [3]. It has been suggested that the involvement of zygapophyseal joints is important in the restriction of spinal mobility [3-5]. This is supported by computed tomography observations, which displayed a significant correlation between changes in the zygapophyseal joints and restriction of spinal mobility [6,7].
Acute inflammation in the spine associated with AS, as detected by magnetic resonance imaging (MRI), has been described in the intervertebral disc, in the vertebra, enthesis of interspinal ligaments, costovertebral joints and zygapophyseal joints [8]. However, systematic MRI of zygapophyseal joints has not been undertaken so far.
As a consequence, a correlation of histopathological analysis of the spine and inflammation as visualized by MRI has also not previously been done. In the sacroiliac joints of patients with AS, a correlation of MRI findings and histopathological evaluations from needle biopsies out of the same sacroiliac joints was reported, but without description and quantification of histological edema [9].
We have recently reported the first systematic histological study of zygapophyseal joints in patients with AS [10]. In the present study, we first examined whether inflammation in the spine of patients with AS, as detected by histopathology, can be correlated with bone marrow edema detected by MRI and consequently whether a negative MRI excludes active inflammation of the spine in patients with AS.
Zygapophyseal joints were obtained from eight patients with AS (mean age 45 (range 30 to 59); five men, three women). This study includes patients from a larger group for which histopathological observations from the zygapophyseal joints were reported recently [10]. In brief, all eight patients had severe kyphosis and were completely ankylosed in the lumbar spine. The mean disease duration of all eight patients was 22.5 years (range 7 to 33 years). Seven of eight patients reported symptoms of nocturnal back pain before surgery. Histologically detectable edema and cellular infiltrates were also searched for in control samples taken from autopsies of 10 patients without AS who died from cardiovascular diseases and had no history of rheumatic diseases.
Surgery was performed as reported in more detail previously [10]: we obtained at least one zygapophyseal joint (Figure (Figure1a)1a) from the lumbar spine of each patient with AS. For all eight patients with AS, preoperative MR images of the lumbar spine and the thoracic spine were available for comparative analysis.
Permission for this study was given by the local ethic committee of the Charité Berlin, Campus Benjamin Franklin. All patients gave permission for histopathological analysis of the obtained material.
The histopathological assessment was performed as described recently [11]. In brief, the zygapophyseal joints were cut into thin slices (3 to 4 mm) with a saw and fixed in 4% buffered formalin. After decalcification with EDTA, sections 4 to 6 μm thick were prepared and stained with hematoxylin and eosin for the evaluation of bone marrow edema. Bone marrow edema was characterized by the accumulation of eosinophilic fluid in the bone marrow interstitium in between univacuolar fat cells, resembling the morphological findings described in the bone marrow of patients with severe malnutrition [12], during the first couple of weeks following stem cell transplantation [13] or after cytoreductive therapy in chronic idiopathic myelofibrosis [14] (Figure (Figure1b;1b; red arrows, edema; black arrow, vacuoles of fat cells). The relative amount of edema, calculated as the percentage of the total bone marrow area, was quantified as described in an earlier study in which bone marrow edema was assessed for a comparative analysis of magnetic resonance (MR) images and histopathology in osteoarthritis [15]. The sections were also examined by polarized light after staining with Congo red to rule out the presence of amyloid mimicking extracellular edema.
The evaluation of all sections was performed by an experienced pathologist (CL) who was blinded for patients, controls, and the MRI results. Sections were examined with a microscope allowing light and immune fluorescence microscopy (BX60; Olympus, Hamburg, Germany). Pictures were taken with a digital camera (Color View II; Soft Imaging System GmbH, Münster, Germany) and were further analyzed by Analysis® software (Soft Imaging System).
Immunohistochemistry was performed, as described in more detail recently [11], to detect CD3+ T cells, CD4+ T cells, CD8+ T cells and CD20+ B cells. In brief, sections were immersed in a sodium citrate buffer solution at pH 6.0 and heated in a high-pressure cooker (CD3, CD4, CD8 and CD20). After cooking, the slides were incubated with the respective primary antibodies including monoclonal antibodies against CD4 (clone 1F6; Novocastra, Newcastle, UK), CD34 (QBend10; Immunotech, Marseille, France), and CD3 (F7.2.38), CD8 (C8/144B) and CD20 (L26) obtained from Dako (Glostrup, Denmark). For detection, the alkaline phosphatase/anti-alkaline phosphatase complex (APAAP) method was used, with 'Fast Red' as chromogen.
T-cell and B-cell aggregates were defined as clusters of 50 or more CD3+ T cells or CD20+ B cells, and for each patient the number of CD3+ T-cell aggregates or CD20+ B-cell aggregates in 10 high-power microscopic fields (HPFs), based on a HPF of 0.237 mm2 first, ocular with a 22 mm field of view at ×10 magnification, and a 40× objective), was assessed. For the quantification of interstitial CD4+ and CD8+ T cells and CD20+ B cells in the bone marrow, 10 HPFs were analyzed similarly. The number of interstitial CD4+ and CD8+ T cells was defined as increased if at least ten CD4+ T cells and at least six CD8+ T cells per HPF were present; for CD20+ B cells the criterion was at least five positive cells per HPF on the basis of the findings in zygapophyseal joints of patients without AS, which we used as negative controls.
The results are given semi-quantitatively: +++, at least two CD3+ lymphocytic aggregates and increased interstitial CD4+, CD8+ and CD20+ lymphocytic infiltrates; ++, one CD3+ lymphocytic aggregate and increased interstitial CD4+, CD8+ and CD20+ lymphocytic infiltrates; +, increased interstitial CD4+, CD8+ and CD20+ lymphocytic infiltrates, no aggregates. For the quantification of CD34+ micro-vessel density a semi-quantitative analysis was performed: 0, not more than two micro-vessels per HPF; +, three or four micro-vessels per HPF; ++, five or six micro-vessels per HPF.
MRI, including T1-weighted, T2-weighted and TIRM (turbo inversion recovery magnitude) sequences, was performed as a preoperative procedure in patients with AS, as shown in Table Table1.1. TIRM sequences allow excellent illustration of the anatomy and detection of inflammation in the bone marrow. The entire lumbar spine including the zygapophyseal joints and, if available, the thoracic spine was analyzed for increased signals in T2-weighted sequences.
We summarize the results of a semi-quantitative analysis of mononuclear cell infiltration in the bone marrow of zygapophyseal joints as described in the Method section. Five patients with AS had the highest score of cellular infiltration (+++) with at least two CD3+ lymphocytic aggregates including increased interstitial CD4+, CD8+ and CD20+ lymphocytic infiltrates, and three patients with AS had an increased level of cellular infiltrations (+) without aggregates (Table (Table11).
To address the question of whether hypervascularization might contribute to the detection of bone marrow edema in the spine by MRI we also stained CD34+ endothelial cells in our sections. This issue was examined more thoroughly in a previous paper [10]. The present results are shown in Table Table11.
All patients with AS showed different degrees of interstitial bone marrow edema in histopathological analysis: in two patients with AS, interstitial edema was present in 10% of the total bone marrow area, in two patients it was present in 20%, in two patients in 30% and in two patients in 60% (Table (Table1).1). In contrast, none of the controls showed interstitial bone marrow edema.
Interstitial bone marrow edema as detected by histopathology in the zygapophyseal joints of the lumbar spine was found by MRI in three of eight patients with AS (Table (Table1).1). Most interestingly, in these patients a good correlation between histopathologically confirmed interstitial edema and cellular infiltration was found. Two patients showed the highest score for interstitial bone marrow edema (60%) and for mononuclear cell infiltrates (+++). An example of such an AS patient is shown in Figure Figure2:2: bone marrow edema as detected by MRI (Figure (Figure2a)2a) was correlated with interstitial bone marrow edema as detected by hematoxylin and eosin staining (Figure (Figure2b)2b) and T-cell infiltration (Figure (Figure2c).2c). The third patient with AS (no. 3) with bone marrow edema detected by MRI had 30% interstitial bone marrow edema and the highest score of bone marrow infiltation in the histopathological assessment. Some of the patients had inflammatory lesions in other parts of the spine, as indicated in Table Table11.
Interestingly, histopathologically detected cellular infiltration and interstitial bone marrow edema was also observed, although to a smaller degree (between 10% and 30%), in patients with negative MRI. An example is shown in Figure Figure3:3: interstitial bone marrow edema (20%) (Figure (Figure3b)3b) and cellular infiltration (Figure (Figure3c)3c) was detectable in histopathological observations but not by MRI (Figure (Figure3a).3a). In two of the patients in whom zygapophyseal joints were MRI-negative, signs of osteitis were seen at other sites of the spine: in the vertebral bodies of thoracic vertebrae 11 and 12 of patient 4 and at posterior sites of the vertebral bodies of thoracic vertebrae 6 to 9 including the zygapophyseal joints of patient 6 (Table (Table11).
Interstitial bone marrow edema in zygapophyseal joints of the lumbar spine as detected by histological examination was present in all eight patients with AS to a different degree, varying from 10% to 60% of the total bone marrow area. There was a clear correlation between histopathologically confirmed interstitial edema and edema as shown by MRI. However, a small amount of histopathological interstitial edema in the bone marrow (less than 30% of the surface area) is not detected by MRI. There was only a poor correlation between histopathologically observed interstitial edema and inflammatory cell infiltration, and therefore only a poor correlation between cell infiltration and MRI edema, which might explain why some patients with AS can have active disease despite a normal MRI [16]. An earlier study comparing AS histology from computed-tomography-guided biopsies from the sacroiliac joint with MRI observed some correlation between cell infiltration and bone marrow edema by MRI but did not investigate and compare histopathological and MRI bone marrow edema [9].
We are aware that this analysis has its limitations: the number of patients in this study is small, all patients had advanced disease progression, the slices of MR images were 4 mm thick or were for example available only in sagittal sections (patients 7 and 8) and because of that it might be possible that inflammation and edema was missed. Furthermore, transverse images of the zygapophyseal joints might be more sensitive [8]. However, the protocol used for MR images is a standard protocol for daily routine and should therefore be used for comparative analysis.
In patients with AS, spinal MRI is being used to assess spinal inflammation as an indicator of disease activity. Lesions of active inflammation are depicted as areas of increased signal intensity in T2-weighted images with fat saturation (STIR sequences) and most probably represent an increased water content, probably as a correlate of bone marrow edema [17]. The term 'bone marrow edema' in MR images was first used by Wilson and colleagues in 1988. Regional decreased signal intensity of the bone marrow in T1-weighted images and increased signal intensity on T2-weighted images represented an accumulation of 'bone marrow water', which could be confirmed by biopsy. They defined such lesions as 'bone marrow edema' [18]. A first systematic analysis of bone marrow edema in MR images and histopathological analysis was performed in osteoarthritis [15] in which bone marrow edema could be observed in MR images in up to 50 to 68% of patients. In this study the bone marrow edema, defined as a hyperintense zone on STIR images and hypointense on T1-weighted MR images, consisted mainly of normal tissue (53% of the area was fatty marrow, 16% was intact trabeculae, and 2% was blood vessels) and in a smaller proportion of other changes, namely interstitial bone marrow edema 4% [15]. Taken as a whole, the study by Zanetti and colleagues [15] revealed non-characteristic histopathological abnormalities without increased infiltrations of mononuclear cells, increased microvessel density or interstitial bone marrow edema, clearly indicating that MRI-detected 'bone marrow edema' in patients with osteoarthritis can have various underlying histomorphological alterations. In our study the presence of large numbers of cellular infiltrates in all patients with a greater percentage of histopathologically confirmed interstitial edema argues strongly for the hypothesis that the bone marrow edema in MRI in our cohort of patients with AS was caused by inflammation.
There is a good correlation between histological and MRI edema in patients with AS, although MRI seems to be less sensitive than histopathological analysis. Edema is a product of inflammatory reaction but our histopathological observations indicate that inflammation reflected by cellular infiltrates does not always cause the same degree of edema. This might be an explanation for the sometimes observed discrepancy between high disease activity and negative MRI in AS. Further investigations comparing radiological and histological changes will be needed to clarify this topic. Therefore, other structures involved in AS, for example hip joints and knees obtained from joint replacement, should be analyzed in future.
AS = ankylosing spondylitis; HPF = high-power field; MR = magnetic resonance; MRI = magnetic resonance imaging; TIRM = turbo inversion recovery magnitude.
The authors declare that they have no competing interests.
HA, CL and JS were responsible for study design, manuscript preparation, data acquisition and interpretation, and statistics. ZG and MR were responsible for acquisition of MRI data and its interpretation, and for manuscript preparation. HE was responsible for data acquisition from patients without AS and for interpretation of data. MD, AH and PM-S were responsible for data acquisition from patients with AS and for interpretation of data. HS was responsible for data acquisition and interpretation and for manuscript preparation. All authors read and approved the final manuscript.
This study was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG) Ap 82/3-1 (to HA and JS) and Project Z1 from the Sonderforschungsbereich (SFB) 633 (to CL and HS).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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2003 Honda Element 5 Door EX (2WD) KA 5MT Accessories
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subset: commoncrawl


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mercedes benz CL-Class Models and CL-Class History
The Mercedes-Benz CL-Class replaces the S-Class coupes for 1998, with new BabySmart airbag technology and BrakeAssist being added as new features. The new model would coast through 1999-2000 relatively unchanged. For 2001, the 362-horsepower V12 CL600 debuted with minor updates to all trim levels. Nothing was new for 2002, with updates to the CL55 and CL600 being the only trim level changes for 2003. The CL500 got a new seven-speed automatic transmission with DVD based navigation and remote entry as well as other options being offered for 2004. Nothing was new for 2005, with the popular AMG sports package getting a major update for 2006. While 2007 yielded no major changes, an all-new CL-Class debuted in 2008, offering a new AMG trim with 518 hp and the 604 hp CL63 trim. All-wheel-drive was added to the CL550 in 2009, with a host of new features that included remote start, heated seats and new interior options. For 2010, a new variable-ratio steering system was made standard alongside new safety equipment. Updates to the various trim levels included subtle changes such as larger wheels and a new 100th Anniversary of Mercedes-Benz Edition. A revamped CL-Class greeted buyers for 2011, with updated interior and exterior styling and two new V8 engines to choose from, with the CL65 boasting 621 hp. The CL-Class would zip through model years 2012-2014 relatively unchanged.


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Rev. Fumiaki Usuki, Resident Minister
As the current President of West Los Angeles Buddhist Temple, I extend to you a warm welcome. Please explore our website to find out who we are, what services and activities we offer, our current calendar of programs, copies of our monthly newsletter, The Bulletin, organizations within our Temple, features, links to other Buddhist sites, and photos you may find of interest. We are a Buddhist Temple following the Pure Land school of Mahayana Buddhism, also known as Shin Buddhism. At the heart of the Shin Buddhist teaching lies a vision of true reality alive with wisdom and compassion working to bring all beings to the highest fulfillment of human life, enlightenment. If you attend some of our services, you can expect to hear an exposition of the dharma emphasizing compassion and wisdom, the interdependence and mutability of all things, attachment as the source of suffering and that is just the beginning.
Our Sangha was formed almost 90 years ago, as one of the branches of Los Angeles Hompa Hongwanji Buddhist Temple in Little Tokyo, by members of the first-generation Japanese-American community in the area centering on Sawtelle Blvd. In 1950, we were chartered as separate temple. Today, we join together with 59 other Shin Buddhist temples throughout the continental United States all of whom are affiliated with our parent organization, Buddhist Churches of America.
We offer a Dharma school program inviting students of all ages from preschool through high school, emphasizing a unique environment for social and religious growth focusing on Buddhist teachings of compassion, friendliness, and harmonious family life. Please join us not only for our Sunday services and other programs, but especially during the last weekend in July (usually) for our Obon festival where we join together both to honor the memory of friends and family who have passed away as well as in a celebration of life with street dancing (bon-odori), music, and food, all in a Gathering of Joy. Make this a year of change by joining us. Please feel free to contact the temple office or myself.
Rob Kafka, Temple President


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When the first trailer for Sofia Coppola's Somewhere broke back in June, it was hard to get a grasp on exactly what the film was about, not because it was complicated but because it was somewhat like looking into a dark void. There is Los Angeles scenery, a lot of white, Elle Fanning looking cute and a lot of silence. Based on that and the first clip from the film, I am curious if more than ten lines of dialogue will be spoken.
Reelz Channel has released the first clip from the film which features Stephen Dorff and Michelle Monaghan taking some publicity photos (they both play actors in the film), and that's about all we get. Ninety percent of the video is the sound of a camera shutter. Here's hoping that when the full film comes out that it's filled with a bit more substance, because this is pretty dry.
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Rick has yet to fill out a bio.
how was the call BS when they rewind every play they call so the viewer at home could see it. if u didnt like the call it doesn't mean it wasnt right. they blew a 14 point lead and got sack 5 times. the ravens suck
Rick, you're not going to change the fact that running the football wins games. You haven't a lick of evidence to support the idea that running a college spread offense is the ticket to winning championships. Just because it has on a few instances does not mean that it is the smartest way to travel .
I'm doubting you're old enough to remember the Run 'N Shoot offenses of the late 80's but those failed for the same reasons that they do today. About the only difference is that most of today's "spread the bunghole" offenses is that there's usually a tight end for blocking.
Either way, just because the league is trying as hard as it can to turn the NFL into the NBA, scoring-wise, by passing 80 times per game doesn't make it very good football.
Stop embarrassing yourself in front of lots of people who just know better.
I take that back ... pathetic try Rick.
You like wins or championships? I like the latter, especially when there's talent that could achieve it.
Be a baseball fan. Hitters there are well paid four performing less than half their at bats. You'd love it ...
I'm a terrible fan for expecting better than Pop Warner? Get real man ...
The most controversial issue of the NFL Hall of Fame, and I'm here to spell it out.. Please leave your comments.


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Rep. Watson Holds Final Year End Legislative Event
Los Angeles, CA- Congresswoman Diane E. Watson (D-33) held her final annual Year End Legislative Review at the California African American Museum on Saturday, December 11, 2010.
In addition to thanking her constituents for their support, the purpose of the Year End Legislative Review was to present her legislative agenda throughout her tenure as a member of the United States House of Representatives.
Representative Watson issued the following statement to her constituents at the Year End Legislative Review Event:
"It is my pleasure to thank all my constituents for giving me the opportunity to represent the 33rd Congressional District in the U.S. House of Representatives over the past ten years. I thank you for the trust you have placed in me for these many years as your voice in the United States Congress," said Rep. Watson.
"As our nation moves forward to meet future challenges, I encourage each of you to remain vigilant, tolerant, optimistic, and engaged. If we continue to follow these principles, our country will continue to prevail because of the spirit and determination of the American people," said Rep


text: I personally reside in Manhattan New York and I'm just perplexed to see the diverse members in this forum. There is a reason why teams are spatially distributed in that it attracts a larger crowd. So my question is for those that don't live in New York, why do you choose to be a fan of the New York Knicks? And what's wrong about your hometown team? It's not like the Knicks is winning in the past decade but it seems like we still maintain that fan base from out of the state. At the end of the day, it's still basketball and fans will be fans.


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YOUNG and old joined forces during a weekend to celebrate the brave efforts of service personnel.
The Our Heroes Matter charity brought a weekend of events to Hartlepool's Heugh Gun Battery.
As well as re-enactments of Durham Light Infantry's heroics from the First and Second World Wars, the weekend also saw the Heugh Battery's 25-pounder cannon being fired at 1pm yesterday to salute fighters – both past and present.
Trevor Gray, volunteer events manager with Our Heroes Matter, said: "The weekend was a great success.
"We had a few visitors but I think a lot had been put off by the heavy rain and snow.
"We still had quite a bit of support, though."
Veterans and members of Hartlepool's Royal Air Force Association (RAFA), along with town-based members of the RAF Regiment Association also attended.
Trevor, 28, who lives in Sunderland and served with the Scots Guards before joining the Territorial Army, and whose father Michael Gray also served with the forces, added: "We still had a lot of interest in the day, including one tourist from Kuwait, who enjoyed the weekend.
"We had First World War re-enactors in trenches, giving talks, and people were quite impressed with that.
"We hope to do something like this again at Easter – the Heugh Gun Battery representatives were very happy with us and have invited us back.
"Hopefully we will have better weather."
Our Heroes Matter is a Sunderland-based charity, which was set up 18 months ago, looking to help ex-service personnel in need by offering help with accommodation, employment training and support, mental health and other support.
Other highlights of the weekend included a tombola, the sale of Our Heroes Matter wristbands as well as music,and a chance to have a look around the battery's museum.


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MASSENA -- The New York Power Authority (NYPA) will offer family movies geared at the Hawkins Point Visitors Center from Feb. 18-21.
The winter break movie festival features three movies daily at 10 a.m., 1 p.m. and 3 p.m. in the theater.
Free popcorn will be available.
Movies and show times are as follows: Feb. 18 at 10 a.m., "Cars"; 1 p.m. "Super Buddies"; 3 p.m. - "Eight Below." Feb. 19 at 10 a.m. "Turbo"; 1 p.m. "Ice Age: Continental Drift"; 3 p.m., "Planes". Feb. 20 at 10 a.m., "Tangled"; 1 p.m., "Cloudy with a Chance of Meatballs 2"; 3 p.m., "Epic." Feb. 21 at 10 a.m., "Monster University"; 1 p.m., "Free Birds", 3 p.m. - "The Croods." The center will be closed Feb. 17 in honor of President's Day. For information, call 315-764-0226 ext. 302.


text: Johannesburg - The rand was softer against the dollar during midday trade on Wednesday as pre-budget jitters kept equities and forex desks on their toes."Today is pretty much about the pre-budget excitement'" said Ockert van Niekerk' head of trading PSG. "We will need to see how Treasury will balance tax increases with bond issues. The rand might react but seems pretty steady at the R8.85/$ level for now."At 11:43' the rand was bid at R8.8540/$ from R8.8219 at Tuesday's close. The local currency was bid at R11.5730/€ from its previous close of R11.5285 and at R13.3731 against sterling from R13.3443 before. The euro was bid at $1.3071 from $1.3068 at Tuesday's close.


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Is LL About to Become Mrs Lindsay Morton?
Yesterday Harry was spotted at Cartier buying a mystery ring and today the couple pop up in Hawaii. Could it be that LL is getting engaged this weekend? Are they messing around with the press or is this for real? Page Six reports:
LINDSAY Lohan's billion-dollar boy toy has only dated her for a month, but he's just shelled out for a pricey a diamond engagement ring. Harry Morton was spotted on a secret trip to Cartier in Beverly Hills where he picked out the sparkler, Extra and Splash News report. A few hours later, Morton, 25, whisked the 20-year-old singer-actress away for a romantic vacation where he's likely to pop the question. An insider said: "He is ready to take their relationship to the next level."
Lots more pics of the couple in Hawaii so


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Home » CLAREMONT, NH Pawn Shops
CLAREMONT Pawnshops
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24 Tremont Sq
Claremont, NH 03743
Claremont, NH 03743
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The end to your money problems is just a pawn shop visit away. Get the cash you need quickly by visiting a New Hampshire pawn shop and applying for a collateral loan or a payday loan. Whatever your need for cash may be, NH pawn shops are a convenient source for quick loans.
Whether you live in Nashua, Derry or Manchester, there is a local New Hampshire pawn shop in your town. Search our comprehensive listings of New Hampshire pawn shops and find one in your community. Read customer experiences and share your own story. If you are a NH pawn shop owner, add and verify your free business listing.


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Custom Fine Art Photo Labs
Tucson, AZ
Photographic Works is where all aspects of photography and fine art printmaking are taken seriously. Each and every day we are committed to providing quality in our services. Our goal is to provide you the very best working experience. We like being liked for what we do. Whether you use film, digital file, or paint we have a wealth of knowledge and experience to handle your needs.
San Francisco, CA
Purely custom b/w & C-type color photographic printing, using traditional (optical, chemical, handmade) means. Printing for exhibition, reproduction, or portfolio purposes. What every job has always had in common is the mutual desire of the client and myself to produce prints which most fully articulate every aspect of what the photographer wants to say.
Los Angeles, CA
PC Colour offers a wide variety of high-quality services including: Durst Lambda prints, film processing, proof and scan services, custom C-type, B&W traditional and digital prints, mounting, framing etc... We have served the professions of fine art photography, wedding photography, and commercial photography since 1987.
Berkeley, CA
Photolaboratory.com provides one stop shopping for busy photographers who shoot film or digital and need custom photo lab services in both color and black and white. We work hard for working photographers, artists, students and anyone who loves true optical black and white silver printing and professional color digital printing on art papers and on photo-graphic papers.
Los Angeles, CA
Custom color fine art printing, Ilfochrome, C-type, Mounting, Digital.
Denver, CO
Fine Art Printing both Photographic and Giclee. We process E6, C41, Black and White Films using the preferred Dip and Dunk processors. Scanning services Drum Scans and Flatbed Scans. We offer our services nationally.
Denver, CO
Professional full service digital imaging specialists with complete experience in digital photographic and fine art printing. We are artists working with artists to co-create fine artwork print editions. Our talents and products also translate perfectly to the corporate world where image is everything to your business. We offer many in-house services from Graphic Design to final Installation of your project. We are happy to show you our many solutions to your fine art or commercial graphic print needs. Other services include: Image Retouching and Restoration, Museum and Visitor Center Display Graphics, Artwork and Display Installation as well as Non-Profit Fundraising Opportunities through our Affiliate and Broker programs.
East Dundee, IL
Since it's founding in 1990 Lightbox has reached out to the photo, and fine-art community. We have cultivated many loyal business relationships as well as wonderful friendships with our clientele. Our loyalty and commitment to our customers has been returned two-fold by way of strong referrals. The Lightbox name is always associated high quality work. Offer wide range of traditional and digital printing including Platinum/Palladium.
Chicago, IL
For over 25 years, the Printlab has been the professional photo lab of choice in Chicago for Fine Art photo printing. Printlab is your creative studio; our business relies upon uncompromising technical precision, skilled craft, and a collaborative environment so that you can concentrate on your business: creating work. We work one-on-one with you to ensure that your vision is met to the strictest of specification producing professional photographic prints of the highest caliber.
Needham, MA
A professional Color and B&W lab, founded in 1988, that services a wide range of artists, museums, institutions, photographers, enthusiasts and anyone in need of quality imaging of any kind. Whether you need critical film processing (E-6, C-41, B&W, Pyro), handmade color or B&W prints, large or small format copy work and duping, museum quality mounting, or digital services ranging from high resolution scanning to large format pigment printing, we can help. Sizes of analog c-prints available up to 72" inches wide!
Hingham, MA
B&W film processing, archival Digital inkjet printing to 44" wide, digital negatives / LVT negatives, photo restoration and Photoshop services, high-resolution scanning
Silver Spring, MD
We professionally process using Dip and Dunk processors, E-6, C-41 and B&W. We also offer many other photo services, printing, duping, framing, scanning,etc. We currently process film for National Geographic, The Library of Congress, The National Archives and the Smithsonian. We have been in business for over 35 years, earlier years under the name Dodge Color, and have a strong photographic background.
Troy, MI
We are a high quality, experienced, custom photo lab offering traditional photo processing and printing as well as several state of the art digital imaging services. Our services include, conventional photo printing, digital printing, fine art Giclée printing on canvas and art paper, film processing, slides, film scanning, computer retouching and print finishing.
Hattiesburg, MS
Finding an establishment that takes your fine art photography and custom prints seriously can be difficult. At PhotoArts Imaging Labs we offer a wide variety of printing services from custom printing to traditional & digital restoration, from toning to hand coloring. We also hand develop B&W and chrome (color slide) films from 35mm to 4x5 sheet film.
Omaha, NE
Offering the finest in digital imaging and wide format printing services to photographers and graphics designers in the Mid West for over 35 years! Our experienced staff of imaging professionals have extensive experience in all phases of digital imaging, traditional photolab services, and as photographers, making us a well rounded group of professionals.
New York, NY
Fine art photographic services including master prints, mural prints, b/w fibre and lambda prints. Sizes from 8x10 inches to over 8x10 feet. Specialists in mural and other large sized printing services.
New York, NY
Custom b/w, color and digital services. Charles Griffin has been providing fine art photographic print for artists, museums and galleries for the past 15 years. Since founding Griffin Editions in 1996, Charles has assembled a staff of artists that specializes in large-scale silver gelatin and digital photographic prints.
Ken Lieberman Photographic Laboratories Inc.
New York, NY
We are a custom photographic laboratory, specializing in printing exhibitions for photographers, galleries and museums, worldwide.
Lightside Photographic Services
New York, NY
Unique service provider with extensive experience and wide range of services. Located in New York City.
New York, NY
Digital fine art printing studio in New York City specializing in archival pigment printing, large format photographic printing, fine art giclee printing, scanning and retouching for photographers and artists.
Rochester, NY
For almost 25 years we've been providing professional photographers, fine artists, and serious amateurs with custom photo laboratory services. Because of our quality and service, we've prospered while our competitors have come and gone.
Portland, OR
Our brick and mortar facility is equipped and ready to handle all of your optical printing needs. Real film, real light, and real lenses make for real photographs. What might possibly be the world's hardest working film lab awaits the opportunity to bring out your images in glowing color and exquisite black and white. We offer scanning services, restoration services as well as custom darkroom work.
Richmond, VA
With a combination of 30 years experience and knowledge in the photographic field and utilizing the latest in the photographic technology, we are able to produce the highest quality in digital and traditional printing, at very low prices. Digital upload, 48 hour service and custom b/w.
Conservatorio della Fotografia
Olgiate Molgora, ITALY
We do most kinds of direct from negative prints. Mainly working on direct chromogenic prints and Platinum palladium prints, we do ancient techniques as well as b&w silver prints.


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Sky Gods for Hire in Cross Country issue 129 argued that flying guides could help hang glider and paraglider pilots skip weeks of do-it-yourself learning. But it also argued you want a sky god for a guide, not a cowboy and asked "Is it time for an internationally recognised standard for fly-guides?"
At the end of the 3,000 word article that looked at the systems around the world, from Spain's authoritarian approach to South Africa's realistic stance to northern Europe's attitude of 'they don't exist' it asked for comments. You can either email the editor at email@example.com or leave your thoughts about such a system on this page here.
Comments may be edited and published in the next issue of Cross Country.
• Got news? Send it to us at firstname.lastname@example.com.
Subscribe to the world's favourite hang gliding and paragliding magazine


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Research Reports for Top Traded Penny Stocks: Vista Gold, Metropolitan & Rare Element Resources, More Reports for Intel, EMC & Macy's
Pennystocksinsiders.com (PSI) has issued Equity Research for top traded penny stocks: Vista Gold (AMEX:VGZ), Metropolitan (AMEX:MDF), Rare Element Resources (AMEX:REE). More reports for Intel (NASDAQ:INTC), EMC (NYSE:EMC) & Macy's (NYSE:M).
Many investors are interested in trading top penny stocks. Given the fact that penny stock prices are highly volatile not many investment banks provide research reports on penny stock companies. However, investors can reduce investment risk by tracking the insider trading activities before buying penny stocks.
(Read full report by clicking the link below, you may need to copy and paste the full link to your browser.)
Research Report Highlights:
Vista Gold Corp. (AMEX:VGZ): Best Performing Low-priced Stock
Insider Trade Signals: Vista Gold Corp. is engaged in the evaluation, acquisition, exploration and advancement of gold exploration and development projects. Vista Gold (AMEX:VGZ) is one of today's best performing low-priced stocks, stock price up to 6.67% today. Want to add and monitor this company on an on-going basis? It can be done for free by registering below.
Read Full Report: http://www.Pennystocksinsiders.com/PR/102511A/VGZ/VistaGold.pdf
Metropolitan Health Networks, Inc. (AMEX:MDF): Company Insiders Granted Options Prior 52-week High
Insider Trade Signals: Shares of Metropolitan Health Networks (AMEX:MDF) traded today at $6.15, breaking its 52-week high. This new high was reached on above average trading volume as 607,000 shares traded hands, while the average 30-day volume is approximately 179,000 shares. PSI found company insiders granted stock shares two weeks ago. Want to track the insiders' trading activities moving forward?
Read Full Report: http://www.Pennystocksinsiders.com/PR/102511A/MDF/Metropolitan.pdf
Rare Element Resources Ltd. Ordinary Shares (Canada) (AMEX:REE): Net Insider Buying in 3 Months
Insider Trade Signals: Rare earth stocks have had a relatively successful week after China's largest rare-earth producer said Tuesday that it would suspend smelting and separation work for a month to use its market power to rally falling rare earth prices. Inner Mongolia Baotou Steel Rare-Earth (Group) Hi-Tech, which accounts for nearly half of the world's light rare-earth production, said that the move was aimed at "balancing supply and demand." Want to know when insiders starting selling? Get an email alert for the latest insider buying/selling by subscribing for free below.
Read Full Report: http://www.Pennystocksinsiders.com/PR/102511A/REE/RareElementResources.pdf
Today Pennystocksinsiders.com also released other research reports for:
Intel Corporation (NASDAQ:INTC)
Read Full Report: http://www.Pennystocksinsiders.com/PR/102511A/INTC/Intel.pdf
EMC Corporation (NYSE:EMC)
Read Full Report: http://www.Pennystocksinsiders.com/PR/102511A/EMC/EMC.pdf
Macy's, Inc. (NYSE:M)
Read Full Report: http://www.Pennystocksinsiders.com/PR/102511A/M/Macys.pdf
More Individual Stock Reports & Sector Reports:
Insider Filing Source Reference: All observations, analysis and reports are based on public information released by the U.S. Securities and Exchange Commission.
About Pennystocksinsiders.com:
Pennystocksinsiders.com features a team of experienced data analysts striving to provide the investment community with the tools, software, and data necessary to carry out more effective investment research.
Important Disclaimer:
Please visit http://www.Pennystocksinsiders.com/disclaimers/index.php for details.
CONTACT: Pennystocksinsiders.com, email@example.com, +1-778-2976120
SOURCE Pennystocksinsiders.com
Reported on Oct 25, 2011
More Insider News ...


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Raymond M.J. Britten
KEOTA — Raymond M.J. Britten, 98, of rural Parnell, died Saturday, Feb. 2, 2013, in the English Valley Care Center in North English.
Funeral Mass will be at 10:30 a.m., Monday, Feb. 11, at Holy Trinity Parish — St. Mary Catholic Church in Keota with the Rev. Charles Fladung officiating. Burial will be in Holy Trinity Cemeteries — St. Mary Catholic Cemetery in Keota. Visitation will be from 4 until 7 p.m. Sunday at the Powell Funeral Home in Keota, where there will be a rosary at 4 p.m. A memorial fund has been established for the Holden Comprehensive Cancer Center. Powell Funeral Home and Cremation Service in Keota is handling the arrangements.


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Posturing Meerkat Pups
In the Botswana's Makgadikgadi Pans, meerkat pups struggle to master the animal's signature upright posture while the adults go in search of food. An adult will often stay behind and babysit the pups while the other meerkats are away from the den. "Great Zebra Exodus" premieres May 15, 2013 at 8/7c (check local listings).
Aired: 05/15/13