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"Each new day is a blank page in the diary of your life. The secret of success is in turning that diary into the best story you possibly can." ~ Douglas Pagels
I hope everyone's new year is off to a good start! I'm happy to announce that Goldie and I will start holding weekly support group meetings by phone every Wednesday beginning February 8th from 8pm to 9pm Central Standard Time.
The first ten people to enroll will be accepted into our first live support group meeting on The Path Forward!
We will be using a tele-conference call service and each member will be provided with a dial-in number and participant pin to call-in and access the meeting. We will be working the Six Steps on The Path Forward in an 8 week session from 2/8/12 to 3/28/12.
If we happen to have a higher demand than anticipated, we will consider adding an additional session on a different night of the week.
If you have any questions, just let Goldie or me know. We look forward to getting you on The Path Forward Now!
Love & Light,
If you are interested,
If you are interested, delight sound on "Additional Hold" and designate your membership to Gilded mothers day wishes The front ten people to recruit give be accepted into click here our original smoldering keep meet meeting on The Path First..
GM Recall
An issue with a steering system component has brought on GM to announce a recall of four huge vehicles, two being SUVs and two are vans. Just less than 6,200 Chevrolet Suburban, Express van and GMC Yukon XL and Savana van models are impacted. You can get good auto loans rates for your new SUV or van.There are a lot of cars that have been recalled by GM lately.These cars will be tested again to see if the problem will still be fixed.


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LSE Advancement aims to support LSE staff in securing funding from external philanthropic sources. With the contacts and resources to access international funders, the Major Gifts team works with individual donors, and the Foundation Partnerships team works with trusts and foundations.
For fundraising enquiries related to Foundation Partnerships, individual contacts have been allocated to departments and centres across the School, listed here.
The office has the expertise and sector knowledge to meet the needs of academics at all levels - from those seeking only a helpful tweak to their project proposals, to those with no experience of philanthropic funding at all. Below are some of the services we provide:
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subset: commoncrawl


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Today's FREE kindle book is The Tuscan's Revenge Wedding (Italian Billionaires Collection) by Jennifer Blake.
Revenge can indeed be sweet…
When her brother's car plunges off a cliff with him and his fiancée in it, Amanda Davies gets the news personally from the fiancée's brother. The devastatingly handsome Italian businessman appears in Atlanta and whisks Amanda off to Italy to be with the hospitalized couple. But could his motive be more?
Don't have a Kindle?
This ebook is specifically for Kindles. However, you can download a free application which enables you to read Kindle ebooks on your computer, iphone, Android, Blackberry, iPad and more.
You can also download the same FREE ebooks for the Nook over at the Barnes & Nobles site!
Why pay for books when you can get them free? See more FREE offers!
Product prices and availability are accurate as of the date/time indicated and are subject to change. Any price and availability information displayed on amazon.com at the time of purchase will apply to the purchase of this product.


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I have a Ford F-250 2002 model. Lat night I went to wrk and was late getting off. When I came hom ethe tank was low and said it had 11 miles to empty. I started the truck. It started fine. Went inside to let it warm up, but upon return it was dead. I wen t and got 2 gallons of diesel and tried to tur it over. It whined and knocked but would not turn over. No check engine lights or anything come on when I turn the ignition to the on position, but when trying to satrt the glow light plug is lit up. Is the truck out of fyuel? Or is it something else? If so, how do I get the truck re-staterted if irs merely ran out of fuel?
have the same problem?
Sunday, December 24th, 2006 AT 9:22 PM


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XML RPC test...
Expand Messages
- Hi everybody,
I (as Non perl programmer) just need to test a XMLRPC Application
and used XMLRPC:Lite:
use XMLRPC::Lite;
my $method = 'cms.getGvOrgPerson';
my $hash = {'userid' => 'blablabla', 'password' => 'blabla'};
my $res = XMLRPC::Lite
-> proxy('https://blabla')
-> call($method, $hash)
-> result;
print @$res;
and all i get back is: a list of hashes.
I'm only interested in the XML Response, so how Do I have to do it?
how do i examine what data exactly is in the response (what keys what
Any help is welcome,
thank you!
Your message has been successfully submitted and would be delivered to recipients shortly.


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PR And Social Media Advice For Startups: Think Small To Get Big
I know your new idea is going to change the world but top blogs and publications want to see signs that the world is actually changing before they take notice.
The way to do that is to start small. Small blogs, small magazines, small radio and TV stations, small social media steps, reaching out to influencers, gaining support, growing strong.
This approach leads to less wasted effort, less disappointment and building a steady social media following.
This doesn't mean you shouldn't swing for the fences along the way, but you have to have a willingness to take baby steps that add up to a marathon.
Look for opportunities to associate yourself with people and brands that are bigger than you, and make them the center of the story. I know... you want to be the star. But start small and ride their coattails until it's time to jump off and run ahead of them.
You don't necessarily need a 20 episode web series that requires 2 months of planning. Look for an online video agency that can create a variety of social media video content like short virals, founder interviews, creative Instagram and Vine videos, short animations, or personalized greetings.
Start sharing content that educates, informs, inspires or entertains people. Even if you're doing B2B marketing, you're still connecting with people. What do the people you're selling to care about? Talk about that. Don't over think it. Just write up a bunch of Tweets and share them. Simple.
Just be sure to check in often to see if anyone cares to chat. Don't leave anyone hanging.
Stop sending out blasts to hundreds of media outlets and journalists. It's time consuming, desperate and ineffective. PR pitches need to be tailored to each outlet and writer. Pick a handful of top choices and hit them up with personalized messages. Look for an agency that understands this. Anyone can make a huge media list. What you do with it determines success.
Give away something small and silly on Twitter. Every contest doesn't have to be a Facebook extravaganza. Just do a lot of them.
Baby steps... and In no time you'll be noteworthy, marketable and on your way!
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Clint Eastwood didn't get old and all wrinkly and such by taking crap from people, especially midget filmmakers obsessed with basketball. He got to be where he is by kicking ass and ignoring names. As you'll recall, bothersome filmmaker Spike Lee called out Eastwood and the Coens during a recent trip to Cannes, but especially Eastwood for not including black actors in his World War II movies "Flags of our Fathers" and "Letters from Iwo Jima". The Coens have kept mum on Lee's accusation regarding their use of violence, but Eastwood has finally spoken up about it.
Eastwood spills it to the Guardian:
Eastwood has no time for Lee's gripes. "He was complaining when I did Bird [the 1988 biopic of Charlie Parker]. Why would a white guy be doing that? I was the only guy who made it, that's why. He could have gone ahead and made it. Instead he was making something else." As for Flags of Our Fathers, he says, yes, there was a small detachment of black troops on Iwo Jima as a part of a munitions company, "but they didn't raise the flag. The story is Flags of Our Fathers, the famous flag-raising picture, and they didn't do that. If I go ahead and put an African-American actor in there, people'd go, 'This guy's lost his mind.' I mean, it's not accurate."
And this is my favorite part:
Eastwood pauses, deliberately – once it would have provided him with the beat in which to spit out his cheroot before flinging back his poncho – and offers a last word of advice to the most influential black director in American movies. "A guy like him should shut his face."
Spike Lee should have realized by now — you don't mess with Dirty Harry. Any other director would have kept mum — imagine arguing with a black director on the issue of race. Talk about a rigged argument! And I suspect Spike Lee knows it, that's why he's so quick to shoot off at the mouth by taking people to task on race issues.


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Newegg got a cease & desist letter from best buy for this
Newegg got a cease & desist letter from best buy for this
I usually find the best buy folks to be pretty informative
boom roasted.
i usually go into best buy knowing that i know more about alot of the stuff than the employees than ask them questions they wouldnt know the answer too so they look stupid. AND I NEVER BUY ANYTHING
hows my posting?
Let me know 954 - 805-6715
I converted to newegg like 4 years ago. Dat savings.
"Dude, Applesauce, aren't you like a cop or something?" -TBABY
Lol well to be fair the only section I only ever ask for help in is computer section... and I admit I don't keep up with computer hardware at all. I would never ask for help in the vidya game section because I KNOW I'm gonna know more there.
"So your 2 HD choices are the Xbox 360 and the Playstation 3. Do you plan on playing games with your gaming system?"
"....and over here we have a massive library of blu ray movies for your PS3 system."
"Dude, Applesauce, aren't you like a cop or something?" -TBABY
"and for the xbox you can optionally buy the HD-DVD player, then go online and for only a few dollars, find many sought-after titles such as The Perfect Storm and Constantine"
"we have ps3s but we'll have to give you a raincheck for games"
There are two people in the bestbuy store that know anything about computers. My cousin is one of them and he works in geeksquad but he doesn't talk to people. He fixes all the computers that get sent in. He hates talking to people and after working retail I would too. So, yes, the bestbuy clerks 9/10 know nothing about computers. thank god for smartphones. Look up the bad reviews on the phone/computer right away.
If You own an superb speed internet connection then it is also achievable toAcess Television on your Pc without any bother and Television quality is also glorious
OMGZ its from reddit, WHERE ARE THE MODS?!!!!!!1!!eleven!!!!!11
The only employees that know anything know the information already. Best buy doesn't require any formal knowledge. A hiring manager literally told my friend, "We mostly just google everything."
well where else are you supposed to learn things
That's what im saying. I mean that's my method and I'm knowledgeable as fuh.
That commercial made me want to use that site, take note fracking subway.
If you know, you newegg. If you're my mom, you "negway"
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Hi, I've really enjoyed playing with your theme for my blog and am very happy with how well it works. I do have one issue, that I'm trying to resolve. I really want to display a list of posts from the current category in the sidebar, and have been having trouble getting one that works with Habitat. The closest one I've found is Related Posts by Category Widget. But when I install it, it works on Individual Post pages, but on the homepage and archive pages it breaks the layout, so that the sidebar displays below the content. Ugh.
I did a compare in the code, which turned up an extra
 tag when I use this plugin. I can't find any div tags in the plugin page, so I'm hoping I can tweak something to make this work.
This is without the plugin on an archive page:

Recent Posts

This is with the plugin: (note the
 after the sidebar_bottom span)

Recent Posts

My blog is at http://rufftoyreviews.com Currently, I have this widget turned off because it makes such a mess of the homepage, but I can put it back in at the bottom of the widget list if that is what is needed.
Assuming this: http://wordpress.org/extend/plugins/ (Purchase code hidden if logged out) / is the plugin you're using, I'll have a play with it on my test site and see if it's a quick fix.
Bear in mind we can't officially support 3rd party plugins but I'll see what I can do.
Thanks so much, I appreciate it.
The topic 'Formatting Issue with Related Posts by Category Widget plugin' is closed to new replies.


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TUR Planner Certification
- BWP TU 01,03 - General Practice TUR Planner Certification or Recertification
General Practice (GP) TUR planners may certify plans for any facility.
- BWP TU 02,04 - Limited Practice TUR Planner Certification or Recertification
Limited Practice (LP) TUR Planners may certify plans only for facilities owned and operated by their employers.
- TUR Planner Continuing Education Credit Pre-Approval Form
Complete this form if you are seeking prior approval of continuing education credit for any activity you have taken or plan to take in preparation for TUR Planner Recertification.
- TURA Resource Conservation Plans & Environmental Management Systems
Certification and continuing education requirements for TUR Planners to certify Resource Conservation Plans and Environmental Management Systems.


text: 651979 1 The Scripps Research Institute Molecular Screening Center LYPLA1_INH_LCMS_ABPP_SILAC_INSITU 2013 10 18 Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA1: LCMS-based cell-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in situ Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Benjamin Cravatt, TSRI Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R01 CA132630 Grant Proposal PI: Benjamin Cravatt, TSRI External Assay ID: LYPLA1_INH_LCMS_ABPP_SILAC_INSITU Name: Late stage assay provider results from the probe development effort to identify selective inhibitors of LYPLA1: LCMS-based cell-based Activity-Based Protein Profiling (ABPP) SILAC selectivity analysis in situ. Description: Protein palmitoylation is an essential post-translational modification necessary for trafficking and localization of regulatory proteins that play key roles in cell growth and signaling. Numerous proteins have been identified as targets of palmitoylation, including cytoskeletal proteins, kinases, receptors, and other proteins involved in various aspects of cellular signaling and homeostasis (1). Using a global chemo-proteomic method for the metabolic incorporation and identification of palmitoylated proteins, we were able to identify hundreds of palmitoylated proteins, revealing palmitoylation as a widespread post-translational modification (PTM) (2). Palmitoylation involves an acyl-thioester linkage to specific cysteines (3,4). Given the labile properties of thioesters, palmitoylation is potentially reversible and may be regulated in a manner analogous to other PTMs (e.g., phosphorylation). As such, identification of proteins responsible for the dynamic modulation of palmitoylation is paramount to understanding its patho/physiological roles. For example, multiple oncogenes, including HRAS and SRC, require palmitoylation for malignant transformation (5), suggesting protein palmitoyl thioesterases may have tumor suppressor activity required to repress aberrant growth signaling. More than a decade ago, the cytosolic serine hydrolase acyl-protein thioesterase 1 (APT1) was identified as an in vitro HRAS palmitoyl thioesterase (6). Initially classified as lysophospholipase 1 (LYPLA1) (7), the enzyme has since been demonstrated to have several hundred-fold higher activity as a protein thioesterase. While the in vitro data (6,8) provided an intriguing clue to its possible role in vivo, prior to our studies, little was known about the in vivo thioesterase activity of LYPLA1. Upon retroviral shRNA knockdown of LYPLA1, we found that HRAS was robustly hyper-palmitoylated, providing the first evidence that the endogenous enzyme is a functional protein palmitoyl thioesterase capable of regulating HRAS palmitoylation in mammalian cells. However, shRNA resulted in only an 80% reduction in LYPLA1 expression (unpublished). LYPLA2 (a.k.a. APT2) is 65% identical to LYPLA1, and also exhibits lysophospholipase activity in vitro, but its potential role as a thioesterase is unknown (9). shRNA knockdown studies of LYPLA2 revealed only partial knockdown of the enzyme, making substrate identification inconclusive (unpublished). A principle goal of post-genomic research is the determination of the molecular and cellular role of uncharacterized enzymes like LYPLA1 and LYPLA2. As such, selective inhibitors of LYPLA1 or LYPLA2 would greatly aid investigations into the biological function of these enzymes. Several inhibitors of LYPLA1 have been described (10,11), but none of these agents have proven capable of inhibiting LYPLA1 activity in cells, and no selective inhibitors of LYPLA2 have been reported to date. To comprehensively identify LYPLA1 and LYPLA2 substrates and functionally test the role of these enzymes in dynamic de-palmitoylation and tumorigenesis, development of high affinity inhibitors, capable of achieving temporal and more complete control over activity, is critical. References: 1. Dekker, F.J., et al., Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat. Chem. Biol., 2010. 6(6): p. 449-56. 2. Duncan, J.A. and A.G. Gilman, A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J. Biol. Chem., 1998. 273(25): p. 15830-7. 3. Sugimoto, H., H. Hayashi, and S. Yamashita, Purification, cDNA cloning, and regulation of lysophospholipase from rat liver. J. Biol. Chem., 1996. 271(13): p. 7705-11. 4. Toyoda, T., H. Sugimoto, and S. Yamashita, Sequence, expression in Escherichia coli, and characterization of lysophospholipase II. Biochim. Biophys. Acta, 1999. 1437(2): p. 182-93. 5. Biel, M., et al., Synthesis and evaluation of acyl protein thioesterase 1 (APT1) inhibitors. Chemistry, 2006. 12(15): p. 4121-43. 6. Deck, P., et al., Development and biological evaluation of acyl protein thioesterase 1 (APT1) inhibitors. Angew. Chem. Int. Ed. Engl., 2005. 44(31): p. 4975-80. 7. Jessani, N., et al., Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc. Natl. Acad. Sci. U. S. A., 2002. 99(16): p. 10335-40. 8. Leung, D., et al., Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nat. Biotechnol., 2003. 21(6): p. 687-91. 9. Bachovchin, D.A., et al., Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nat. Biotechnol., 2009. 27(4): p. 387-94. 10. Forner, F., et al., Quantitative proteomic comparison of rat mitochondria from muscle, heart, and liver. Mol. Cell. Proteomics, 2006. 5(4): p. 608-19. 11. Schubert, C., The genomic basis of the Williams-Beuren syndrome. Cell. Mol. Life Sci., 2009. 66(7): p. 1178-97. Keywords: late stage, late stage AID, assay provider, powders, LYPLA1, lysophospholipase 1, APT1, acyl-protein thioesterase 1, serine hydrolase, palmitoylation, protein palmitoylation, counterscreen, inhibitor, inhibition, selectivity, anti-targets, liquid chromatography, LC, tandem mass spectrometry, MS/MS, activity-based protein profiling, ABPP, stable isotope labeling with amino acids in cell culture, SILAC, ABPP-SILAC, inhibitor, inhibition, fluorophosphonate-peg-biotin, FP-PEG-biotin, BW5147-derived murine T-cell hybridoma cells, BW5147, murine T-cell hybridoma, in situ, Scripps, Scripps Research Institute Molecular Screening Center, SRIMSC, Molecular Libraries Probe Production Centers Network, MLPCN Assay Overview: The purpose of this assay is to determine the selectivity profile of powder samples of test compounds using stable isotope labeling with amino acids in cell culture (SILAC) ABPP. In this assay, cultured HEK293T cells are metabolically labeled with light or heavy amino acids. Light and heavy cells are treated with test compound and DMSO, respectively, in situ, followed by the cell-permeable alkyne-functionalized triazole urea ABPP probe NHU5. NHU5 covalently reacts with a subset of serine hydrolases, including LYPLA1 and LYPLA2, and shows slower reaction kinetics than other cell-permeable serine hydrolase-specific ABPP probes (e.g., FP-alkyne), facilitating analysis of target inhibition by reversible compounds. Cells are harvested, proteome fractions isolated and reacted with a biotin-functionalized azide tag under copper(I)-catalyzed azide-alkyne cycloaddition ("click chemistry") reaction conditions for enrichment of probe-tagged proteins. Light and heavy samples are combined in a 1:1 (w/w) ratio. Biotinylated proteins are enriched, trypsinized, and analyzed by LC/LC-MS/MS (MudPIT). Inhibition of target and anti-target activity is quantified by comparing intensities of light and heavy peptide peaks. As designed, compounds that act as inhibitors will block NHU5 probe labeling, reducing enrichment in the inhibitor-treated (light) sample relative to the DMSO-treated (heavy) sample, resulting in a smaller light/heavy ratio for each protein. Proteins not targeted by inhibitors would be expected to have a ratio close to 1. Protocol Summary: Sample Preparation: HEK293T cells were initially grown for 6 passages in either light or heavy SILAC DMEM medium supplemented with 10% dialyzed FCS and 1x PenStrep Glutamine in a humidified incubator (37 C, 5% CO2). Light medium was supplemented with 100 ug/mL L-arginine (Sigma) and 100 ug/mL L-lysine (Sigma). Heavy medium was supplemented with 100 ug/mL [(isotope-13)C6(isotope-15)N4]-L-Arginine (Isotek) and 100 ug/mL [(isotope-13)C6(isotope-15)N2]-L-Lysine (Isotek). Light cells were treated with test compound (5 uM) and heavy cells were treated with DMSO for 3 hours at 37 C. Activity-based alkyne probe NHU5 (50 uM) was added, and cells incubated for 1 hour at 37 C. After 1 hour, cells were washed (4x DPBS), harvested, isolated by centrifugation at 1,400 x g for 3 minutes, re-suspended in methanol/chloroform/dH2O (4:1:3 v/v), and vortexed. After centrifugation at 13,000 x g for 3 minutes, the upper layer was removed and 3 volumes of methanol were added and the solution vortexed. Protein was pelleted by centrifugation at 13,000 x g for 6 minutes. The supernatant was removed and the pellet was air-dried and re-suspended in PBS by sonication. Light and heavy proteomes were mixed in 1:1 (w/w) ratio to generate one membrane and one soluble sample. For affinity purification of probe-labeled proteins, click chemistry with a biotin-azide tag (biotin-N3; 100 uM) was carried out under standard conditions (1 mM TCEP, 100 uM TBTA ligand, 1 mM Cu(II)sulfate, 1 hour, 25 C), and excess reagents removed by washing the precipitated protein with cold methanol (3 x 750 uL). The protein pellets were resolubilized in 2.5% SDS/DPBS (750 uL) by sonication and heating (60 C, 5 minutes). The concentration of SDS was reduced to 0.5% with DPBS (3 mL), and biotinylated proteins enriched with streptavidin beads (50 uL, 1 hour, 25 C). The beads were washed with 1% SDS in DPBS (1x), 6 M urea (1x), and DPBS (2x), then resuspended in in 6 M urea (150 uL), reduced with 5 mM TCEP for 20 minutes, and alkylated with 10 mM iodoacetamide for 30 minutes at 25 C in the dark, and urea concentration was reduced to 2 M with 2x volume DPBS. On-bead digestions were performed for 12 hours at 37 C with sequence-grade modified trypsin (Promega; 2 ug) in the presence of 2 mM CaCl2. Peptide samples were acidified to a final concentration of 5% (v/v) formic acid and stored at -80 C prior to analysis. LC-MS/MS analysis: Samples were analyzed by multidimensional liquid chromatography tandem mass spectrometry (MudPIT) using an Agilent 1100-series quaternary pump and Thermo Scientific LTQ Orbitrap ion trap mass spectrometer. Peptides were eluted in a 5-step MudPIT experiment using 0%, 25%, 50%, 80%, and 100% salt bumps of 500 mM aqueous ammonium acetate and data were collected in data-dependent acquisition mode with dynamic exclusion turned on (60 s, repeat of 1). Specifically, one full MS (MS1) scan (400-1800 m/z) was followed by 7 MS2 scans of the most abundant ions. The MS2 spectra data were extracted from the raw file using RAW Xtractor (version 1.9.1; publicly available at http://fields.scripps.edu/downloads.php). MS2 spectra data were searched using the Sequest algorithm against the latest version of the mouse IPI database concatenated with the reversed database for assessment of false-discovery rates. Sequest searches allowed for static modification of cysteine residues (+57.02146 due to alkylation), methionine oxidation (+15.9949), mass shifts of labeled amino acids (+10.0083 R, +8.0142 K) and no enzyme specificity. The resulting MS2 spectra matches were assembled into protein identifications and filtered using DTASelect (version 2.0) using the --modstat, --mass, and --trypstat options (applies different statistical models for the analysis of high resolution masses, peptide digestion state, and methionine oxidation state respectively). Ratios of light/heavy peaks were calculated using in-house software and normalized at the peptide level to the average ratio of all non-serine hydrolase peptides. Reported ratios represent the mean of all unique, quantified peptides per protein and do not include peptides that were >3 standard deviations from the median peptide value. Proteins with less than three peptides per protein ID were not included in the analysis. Ratio = Average( AUC_light / AUC_heavy ) calculated for all unique peptides Where: AUC_light is the area-under-the-curve for the light peptide pair from cells treated with test compound. AUC_heavy is the area-under-the-curve for the heavy peptide pair from cells treated with DMSO. PubChem Activity Score and Outcome: The following applies to each panel in this assay: A compound was considered active for a particular target/anti-target with a light/heavy ratio of less than or equal to 0.5. A compound was considered inactive for a specified target/anti-target with a light/heavy ratio of greater than 0.5. Overall Outcome and Score: A compound was considered active if it was active for LYPLA1 and inactive for all other serine hydrolases tested, otherwise inactive. The PubChem Activity Score is assigned a value of 100 for active compounds, and 0 for inactive compounds. The PubChem Activity Score range for active compounds is 100-100. There are no inactive compounds. List of Reagents: HEK293T cells (provided by Assay Provider) SILAC DMEM Medium (Thermo 89985) dialyzed FCS (Gemini 100-108) 1x PenStrep Glutamine (CellGro 30-002-CI) L-Arginine (Sigma A6969) L-Lysine (Sigma L9037) [(isotope-13)C6(isotope-15)N4]-L-Arginine (Sigma 608033) [(isotope-13)C6(isotope-15)N2]-L-Lysine (Sigma 608041) DPBS (Cellgro 20-031-CV) FP-PEG-biotin (provided by Assay Provider) PD-10 desalting columns (GE Healthcare 17-0851-01) SDS (Sigma L6026) Urea (Fisher U15-3) DTT (Sigma 43815) Iodoacetamide(Sigma I1149) Trypsin (Promega V5111) CaCl2 (Sigma C1016) streptavidin beads (Pierce 20349) Fused-silica (Agilent 160-2635-10) Aqua C18 (Phenomenex 04A-4299) Acetonitrile (Fisher A955-4) Millipore-filtered Water Formic acid (Fluka 06440) Triton-X100 (Fisher AC21568-0010) This assay was performed by the assay provider with powder samples of synthetic compounds. 2202 Summary (LYPLA1 inhibitors) 2203 Summary (LYPLA2 inhibitors) 2174 Primary screen (LYPLA1 inhibitors in singlicate) 2233 Confirmation screen (LYPLA1 inhibitors in triplicate) 2177 Primary screen (LYPLA2 inhibitors in singlicate) 2232 Confirmation screen (LYPLA2 inhibitors in triplicate) 493105 Confirmation screen (LYPLA1 and LYPLA2 inhibitors in singlicate) 493108 Late stage screen (LYPLA1 and LYPLA2 inhibitors in singlicate) 493109 Late stage LCMS assay (LYPLA1) 493110 Late stage dose response (LYPLA1 and LYPLA2 inhibitors in triplicate) 493111 Late stage screen (LYPLA1 and LYPLA2 inhibitors in singlicate) 493154 Late stage dose response counterscreen (ABHD11 inhibitors in triplicate) 493161 Late stage dose response counterscreen (T-cell cytotoxicity in quadruplicate) 504482 Late stage dose repsonse (ABHD11 inhibitors in triplicate) 504498 Late stage MOA assay (ABDH11 LCMS) 504505 Late stage screen (ABHD11 inhibitors in singlicate, in situ) 504507 Late stage dose response (ABHD11 inhibitors in triplicate) 504510 Late stage dose repsonse counterscreen (T-cell cytotoxicity in quadruplicate) 504520 Late stage screen (LYPLA1 and LYPLA2 inhibitors in singlicate) 504522 Late stage panel screen (ABHD11 SILAC ratio) 504892 Late stage counterscreen (ABHD11 inhibitors in singlicate) http://mlpcn.florida.scripps.edu 20418879 Reference (1) 9624183 Reference (2) 8631810 Reference (3) 10064901 Reference (4) 16528788 Reference (5) 16003812 Reference (6) 12149457 Reference (7) 12740587 Reference (8) 19329999 Reference (9) 16415296 Reference (10) 19039520 Reference (11) 1 Outcome [LYPLA1] One of Active, Inactive, or Not Tested 2 254 1 2 2 Mean Ratio [LYPLA1] Calculated inhibitor-treated/DMSO ratio for LYPLA1 as mean for all unique peptides quantified 1 16 5 5 1 1 3 Standard Deviation [LYPLA1] Calculated standard deviation for mean 1 254 1 1 4 Outcome [PNPLA8] One of Active, Inactive, or Not Tested 2 254 2 2 5 Mean Ratio [PNPLA8] Calculated inhibitor-treated/DMSO ratio for PNPLA8 as mean for all unique peptides quantified 1 16 5 5 2 1 6 Standard Deviation [PNPLA8] Calculated standard deviation for mean 1 254 2 1 7 Outcome [DDHD1] One of Active, Inactive, or Not Tested 2 254 3 2 8 Mean Ratio [DDHD1] Calculated inhibitor-treated/DMSO ratio for DDHD1 as mean for all unique peptides quantified 1 16 5 5 3 1 9 Standard Deviation [DDHD1] Calculated standard deviation for mean 1 254 3 1 10 Outcome [PPME1] One of Active, Inactive, or Not Tested 2 254 4 2 11 Mean Ratio [PPME1] Calculated inhibitor-treated/DMSO ratio for PPME1 as mean for all unique peptides quantified 1 16 5 5 4 1 12 Standard Deviation [PPME1] Calculated standard deviation for mean 1 254 4 1 13 Outcome [ESD] One of Active, Inactive, or Not Tested 2 254 5 2 14 Mean Ratio [ESD] Calculated inhibitor-treated/DMSO ratio for ESD as mean for all unique peptides quantified 1 16 5 5 5 1 15 Standard Deviation [ESD] Calculated standard deviation for mean 1 254 5 1 16 Outcome [ABHD10] One of Active, Inactive, or Not Tested 2 254 6 2 17 Mean Ratio [ABHD10] Calculated inhibitor-treated/DMSO ratio for ABHD10 as mean for all unique peptides quantified 1 16 5 5 6 1 18 Standard Deviation [ABHD10] Calculated standard deviation for mean 1 254 6 1 19 Outcome [LYPLA2] One of Active, Inactive, or Not Tested 2 254 7 2 20 Mean Ratio [LYPLA2] Calculated inhibitor-treated/DMSO ratio for LYPLA2 as mean for all unique peptides quantified 1 16 5 5 7 1 21 Standard Deviation [LYPLA2] Calculated standard deviation for mean 1 254 7 1 22 Outcome [TPP2] One of Active, Inactive, or Not Tested 2 254 8 2 23 Mean Ratio [TPP2] Calculated inhibitor-treated/DMSO ratio for TPP2 as mean for all unique peptides quantified 1 16 5 5 8 1 24 Standard Deviation [TPP2] Calculated standard deviation for mean 1 254 8 1 25 Outcome [PREP] One of Active, Inactive, or Not Tested 2 254 9 2 26 Mean Ratio [PREP] Calculated inhibitor-treated/DMSO ratio for PREP as mean for all unique peptides quantified 1 16 5 5 9 1 27 Standard Deviation [PREP] Calculated standard deviation for mean 1 254 9 1 28 Outcome [FASN] One of Active, Inactive, or Not Tested 2 254 10 2 29 Mean Ratio [FASN] Calculated inhibitor-treated/DMSO ratio for FASN as mean for all unique peptides quantified 1 16 5 5 10 1 30 Standard Deviation [FASN] Calculated standard deviation for mean 1 254 10 1 31 Outcome [CTSA] One of Active, Inactive, or Not Tested 2 254 11 2 32 Mean Ratio [CTSA] Calculated inhibitor-treated/DMSO ratio for CTSA as mean for all unique peptides quantified 1 16 5 5 11 1 33 Standard Deviation [CTSA] Calculated standard deviation for mean 1 254 11 1 34 Outcome [PNPLA6] One of Active, Inactive, or Not Tested 2 254 12 2 35 Mean Ratio [PNPLA6] Calculated inhibitor-treated/DMSO ratio for PNPLA6 as mean for all unique peptides quantified 1 16 5 5 12 1 36 Standard Deviation [PNPLA6] Calculated standard deviation for mean 1 254 12 1 37 Outcome [APEH] One of Active, Inactive, or Not Tested 2 254 13 2 38 Mean Ratio [APEH] Calculated inhibitor-treated/DMSO ratio for APEH as mean for all unique peptides quantified 1 16 5 5 13 1 39 Standard Deviation [APEH] Calculated standard deviation for mean 1 254 13 1 40 Outcome [ABHD6] One of Active, Inactive, or Not Tested 2 254 14 2 41 Mean Ratio [ABHD6] Calculated inhibitor-treated/DMSO ratio for ABHD6 as mean for all unique peptides quantified 1 16 5 5 14 1 42 Standard Deviation [ABHD6] Calculated standard deviation for mean 1 254 14 1 43 Outcome [DPP9] One of Active, Inactive, or Not Tested 2 254 15 2 44 Mean Ratio [DPP9] Calculated inhibitor-treated/DMSO ratio for DPP9 as mean for all unique peptides quantified 1 16 5 5 15 1 45 Standard Deviation [DPP9] Calculated standard deviation for mean 1 254 15 1 46 Outcome [LYPLAL1] One of Active, Inactive, or Not Tested 2 254 16 2 47 Mean Ratio [LYPLAL1] Calculated inhibitor-treated/DMSO ratio for LYPLAL1 as mean for all unique peptides quantified 1 16 5 5 16 1 48 Standard Deviation [LYPLAL1] Calculated standard deviation for mean 1 254 16 1 49 Outcome [PLA2G4A] One of Active, Inactive, or Not Tested 2 254 17 2 50 Mean Ratio [PLA2G4A] Calculated inhibitor-treated/DMSO ratio for PLA2G4A as mean for all unique peptides quantified 1 16 5 5 17 1 51 Standard Deviation [PLA2G4A] Calculated standard deviation for mean 1 254 17 1 52 Outcome [ABHD12] One of Active, Inactive, or Not Tested 2 254 18 2 53 Mean Ratio [ABHD12] Calculated inhibitor-treated/DMSO ratio for ABHD12 as mean for all unique peptides quantified 1 16 5 5 18 1 54 Standard Deviation [ABHD12] Calculated standard deviation for mean 1 254 18 1 2 0 1 R01 CA132630 4 Targets 1 LYPLA1 acyl-protein thioesterase 1 [Homo sapiens] 5453722 1 9606 10434 2 PNPLA8 calcium-independent phospholipase A2-gamma isoform 1 [Homo sapiens] 48525351 1 9606 50640 3 DDHD1 phospholipase DDHD1 isoform c [Homo sapiens] 237757346 1 9606 80821 4 PPME1 protein phosphatase methylesterase 1 isoform a [Homo sapiens] 7706645 1 9606 51400 5 ESD S-formylglutathione hydrolase [Homo sapiens] 33413400 1 9606 2098 6 ABHD10 alpha/beta hydrolase domain-containing protein 10, mitochondrial isoform 1 precursor [Homo sapiens] 8923001 1 9606 55347 7 LYPLA2 acyl-protein thioesterase 2 [Homo sapiens] 9966764 1 9606 11313 8 TPP2 tripeptidyl peptidase II [Homo sapiens] 119629464 1 9606 7174 9 PREP prolyl endopeptidase [Homo sapiens] 41349456 1 9606 5550 10 FASN fatty acid synthase [Homo sapiens] 41872631 1 9606 2194 11 CTSA lysosomal protective protein isoform a precursor [Homo sapiens] 119395729 1 9606 5476 12 PNPLA6 neuropathy target esterase isoform a [Homo sapiens] 260656037 1 9606 10908 13 APEH acylamino-acid-releasing enzyme [Homo sapiens] 23510451 1 9606 327 14 ABHD6 monoacylglycerol lipase ABHD6 [Homo sapiens] 189027141 1 9606 57406 15 DPP9 RecName: Full=Dipeptidyl peptidase 9; Short=DP9; AltName: Full=Dipeptidyl peptidase IV-related protein 2; Short=DPRP-2; AltName: Full=Dipeptidyl peptidase IX; Short=DPP IX; AltName: Full=Dipeptidyl peptidase-like protein 9; Short=DPLP9 67460390 1 9606 91039 16 LYPLAL1 lysophospholipase-like protein 1 [Homo sapiens] 20270341 1 9606 127018 17 PLA2G4A cytosolic phospholipase A2 [Homo sapiens] 23943920 1 9606 5321 18 ABHD12 monoacylglycerol lipase ABHD12 isoform a [Homo sapiens] 109689718 1 9606 26090


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Corporate Governance Lawyers and Law Firms in Ridgewood, NJ
Corporate Governance Lawyers
Rabner Baumgart Ben-Asher & Nirenberg, P.C.
New Jersey Employment Law Attorneys(973) 744-4000
Rabner Baumgart Ben-Asher & Nirenberg, P.C. is located in Upper Montclair, New Jersey and provides a variety of legal services to clients throughout New Jersey and New York. Employment law practice areas encompass employment law including discrimination, retaliation and whistleblower...
Law Firm's Overview
Goldstein, Vespi & Vazquez Law Firm
Alternative Dispute Resolution Lawyers in New Jersey(973) 595-5727
Goldstein, Vespi & Vazquez is a full service, regional law firm with a reputation for providing the highest quality, result-driven legal services to corporate and individual clients.
Our clients are a diverse mix of businesses and people who have a common desire to collaborate...
Law Firm's Overview
Gronsky Law OfficeRidgewood, NJ 07450
Small Business and Real Estate Law Attorney in New Jersey(201) 251-8001
Robin M. Gronsky has concentrated her law practice on helping small businesses and families in Bergen, Passaic, and Essex counties realize their dreams and avoid legal headaches. She will help your small business from start-up through contract preparation, negotiation, and review, through assisting...
Bertone Piccini LLPHasbrouck Heights, NJ - Law Firm near Ridgewood
Corporate & Business Attorneys in New Jersey(201) 483-9333
Bertone Piccini LLP is a boutique women owned law firm located in Hasbrouck Heights, New Jersey and certified by the State of New Jersey as a Women Owned Business Enterprise (WBE). The Firm is led by managing partner Grace C. Bertone, a seasoned attorney who was previously a member of a large New...
Cassese & Kim, PLLCPalisades Park, NJ - Law Firm near Ridgewood
Immigration, Real Estate, and Business Law Attorneys(201) 714-2320
Cassese & Kim, PLLC is a general practice law firm centrally located in Palisades Park, New Jersey with its satellite office in White Plains, New York.; We are aptly licensed to practice in the States of New York, New Jersey, and Connecticut and accordingly provide a broad range of legal services...
Ibrahim Law Group, P.C.Clifton, NJ - Law Firm near Ridgewood
New Jersey Criminal Defense Law Firm(973) 400-4080
If you or someone you know in New Jersey needs legal assistance with any legal matter, you may find legal help from the attorneys at Ibrahim Law Group. Our firm is dedicated to assisting clients throughout New Jersey who are facing legal proceedings of any kind. Our objective is to fight for your...
Law Offices of Michele A. Peters, P.C.North Haledon, NJ - Law Firm near Ridgewood
Real Estate Law -- Business Law - Wills, Trusts and Estates(201) 225-8233
Midtown Manhattan full service law firm working primarily in real estate, business, and estate law offers legal solutions including mediation services at reasonable rates for our clients. We are strong advocates for alternative dispute resolution.
The DeSantis Firm, LLCEnglewood Cliffs, NJ - Law Firm near Ridgewood
Full Service Law Firm in Englewood Cliffs, New Jersey(201) 984-5022
The DeSantis Firm is an innovative, unique, and highly responsive law firm located in Englewood Cliffs, New Jersey dedicated to offering a full range of business and personal legal services to clients throughout New Jersey. We are here to serve you and to help you with all of your legal needs...


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(The following statement was released by the rating agency)
March 14 - Fitch Ratings says that the recent partial lifting of ban on cotton exports by the Indian government has created uncertainty over cotton prices and timing of cotton buying for domestic textile companies.
"The ban may provide temporary relief to domestic textile companies in the form of lower raw material prices, but the government's policy flip-flop will give rise to uncertainty over the direction of cotton prices over the long-term," says Tanu Sharma, Associate Director in Fitch's Corporates team.
This uncertainty on cotton price movements could over the long term increase raw material price risk and inventory carrying risk for textile companies, which have been struggling to manage liquidity and working capital in a difficult operating environment.
The ban was initially imposed on 5 March 2012 to curb speculation and ensure domestic availability of cotton following a sudden surge in cotton exports to China in February 2012-March 2012. The government then partly reversed its decision by allowing shipments of quantities that have already been registered and suspending fresh cotton exports indefinitely. However, the offtake is slow in both domestic and export markets and cotton production is in surplus. Consequently, even before the ban was imposed, domestic cotton prices were hovering around the minimum support price levels (INR33-34 per kg).
Uncertain regulatory policy in the past has had conflicting impact on different parts of the textile value chain in India. If the ban remains in force, domestic cotton prices will fall leading to a one-off benefit in the form of lower raw material prices for domestic textile companies, including cotton yarn manufacturers, fabric makers and apparel companies. However, cotton traders and ginners could suffer losses on existing stocks, if they have procured more than the orders received. Inventory losses for yarn manufacturers might not be as pronounced as those seen in 2011, given that many companies have refrained from building up large stocks. As a longer lasting impact of the imposition of the ban cotton acreage may fall next year as farmers will be discouraged to grow cotton and opt for other cash crops instead.
In the year to date, 9.5 million bales (1 bale = 170kg) have been exported, with another 3.5 million bales registered for export, against 5.1 million bales exported in FY11.


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MyCsa (0)
The global speaker bureau
Roy Walker, well known to TV viewers through the ITV game show, Catchphrase, has emerged as one of the driest comedians in Britain today. Roy appears regularly on television and radio in the UK and he continues to headline concert, theatre and cabaret engagements throughout Britain and overseas.
"To be honest, when I am on stage, I'm just being myself"
Roy broke through to success and national prominence when he recorded the highest marks ever given to a comedian on television's New Faces. It was the start of a television career that has blossomed ever since and has seen him starring on all the major TV variety shows. It was at the beginning of 1987 that he hosted his first series of Catchphrase which went on to become a very popular and high-rating addition to the ITV Network scheduling each year. More recently it has also been screened on Challenge TV.
What he offers you
Roy's lugubrious style of humour his dead-pan expression and his approach to entertaining have paid handsome dividends. His casual line in patter has endeared him to audiences all over the country.
How he presents
A true professional and affable character, Roy Walker is an excellent host and his sharp wit and quick retorts are always well-received.
He presents in English.
Want to know more?
Give us a call or send us an e-mail to find out exactly what he could bring to your event.
How to book Roy Walker?
Simply phone, fax or e-mail us.
To discuss how we can help find the right speaker for your organization,
call us on +44 1628 601 400


text:
Harris' family excited to see him potentially face Chipper
Harris' family excited to see him potentially face Chipper
DENVER -- Reliever Will Harris, who is from Baton Rouge, La., said about 10 family members from there, including his wife, 4-month-old daughter and father-in-law, and from Eunice, La., are making the eight-hour drive to Atlanta where the Rockies begin a four-game series Monday.
Harris said his family members are Braves fans and are excited to see Chipper Jones in the waning days of his Braves career and to see Harris possibly pitch for the Rockies.
And if future Hall of Famer Jones should come to bat against Harris?
"They're going to root for me," he said.


text:
Rights holders often take extreme measures to combat piracy, but that a Government institution creates a 'pirate' honeypot is quite exceptional. In Portugal, a collaboration between a Ministry of Culture affiliated organization and the local music industry has resulted in a protocol that calls for such a honeypot, in order to shame, scare and threaten those who download music without authorization.
Among file-sharers the term 'honeypots' is used to describe sites and services that are specifically set up to lure people into downloading copyrighted files. The label is often applied to suspicious looking sites, but proof of the existence of live honeypots is never provided.


text:
Metal: 18K Yellow Gold / Platinum Marked/tested: Tiffany & Co, Pt950, 750, 04953 Gemstones/diamonds: Diamonds - Approx. 1.00Ctw Clarity: Vs Color: G Measurements: Ring Size 5.75,7Mm Wide (Inch = 25Mm) Weight: 8.1g
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62883 Leatherwood Rd
Cambridge, OH 43725 - Guernsey County
(740) 439-3123
Lloyd's Towing Service in Cambridge, OH - Guernsey County is a business listed in the categories Towing, Auto Towing Services and Towing Services. If you did business with Lloyd's Towing Service, please leave a review and help us improve and help other people. Also, don't forget to mention Hubbiz.
62883 Leatherwood Rd
Cambridge, OH
11427 E Pike Rd
Cambridge, OH


text:
Rihanna is back home in Barbados today for the end of Crop Over, a festival celebrating the end of the sugar cane harvest. And today they had the Grand Kadooment Parade, which is why she's dressed like this. Or maybe this is how they always dress. I don't even know where the fuck Barbados is to be honest with you.
The Barbados Tourism Department says...
It is 'Kadooment Day' and the `Last Lap', this is when a culmination of the Island`s top Costume Designers and Bandleaders, masquerade with thousands of revelers in front of judges along the streets, climaxing at the Spring Garden Highway.
You get an 'A' for effort Barbados Tourism Department, but I'm still not going, because this sounds like Mardi Gras but instead of drunk sorority girls showing their tits for beads, it's old ladies dunking a doll stuffed with hay in chicken blood and then stabbing it. For beads.
(image source = splash)


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If you still don't have a presidential candidate next May, perhaps you should consider going for Senator Miriam Defensor Santiago, should she decide to run. The odds against Miriam winning may be a lot greater than when she first sought the presidency in 1992, but that is not reason enough not to vote for her.
Writing in her Facebook account last Wednesday, Miriam broached the idea of reprising her Cinderella run, when she captured the imagination of a voting public that was tired of the scorched-earth politics of 23 years ago and looking for an alternative, reform-oriented candidate. In that seven-way battle, Miriam placed second with 4,468,173 votes (19.72 percent), losing only to Fidel V. Ramos, who got 5,342,521 votes (23.58 percent).
"I'm not going to be coy," Santiago wrote. "Society leaders have urged me to seek the presidency. I can rise to the occasion."
Yesterday, Miriam took to Facebook again. "I first ran for President in 1992 against politicians who had at their disposal both money and machinery," she said. "I, on the other hand, only had the will of the people behind me."
Of course, Santiago has long insisted that Ramos cheated her out of a win in 1992. To this day, she has not forgiven the political operators of the Ramos camp whom she accuses of robbing her of victory.
Miriam is still very much a political force to reckon with. Her two bestselling "Stupid is Forever" joke books, her enviable social media presence and her backbreaking tour of the campus lecture circuit have ensured that she is still as relevant —if not more relevant—than when she started out as a tough-as-nails former judge with the gift of putting down her foes.
Yes, Miriam has also been slowed down by cancer, which she says she has been cured of. But the illness, thank goodness, has not stopped her from venting her ire on the corrupt, the incompetent and the stupid— and those who are all of those at the same time.
I've always been a Miriam fan, of course. And if she runs, I will have to seriously revisit my own evaluation of the current field.
* * *
Unless you're blind or don't venture out of the house, you couldn't have missed those posters put up all over Metro Manila this week, featuring the faces of Davao City Mayor Rodrigo Duterte and Senator Alan Peter Cayetano with the captions "Para Sa Pagbabago!" and "Laban Na!" And maybe you, too, have asked: "What's going on here?"
Well, it's pretty obvious that the posters have been put up by the people of Cayetano, who is desperately seeking Duterte as his presidential candidate. Whether or not Duterte will be convinced by Cayetano to run with him (or even to run at all) remains to be seen.
My sources in the Davao mayor's camp tell me that, yes, Duterte is probably running for the highest office in the land. But he's not really made up his mind about whether to name Cayetano or his other suitor, Senator Ferdinand "Bongbong" Marcos Jr., as his running mate.
Right now, the Intramuros proclamation set for tomorrow, which I reported in this column yesterday, is still an all-Marcos gig, these sources have told me. Just like the blanket (and expensive) postering in Metro Manila appears to be an all-Cayetano affair.
If Duterte is declaring his intentions, I'm told, it's not going to happen tomorrow, a Saturday, apparently because the mayor doesn't think it's a propitious day to make such an important announcement. If the mayor is declaring, they said, he's going to do it on Sunday, right before the end of the filing deadline next week.
The people trying to convince Duterte to declare his intentions either with Cayetano or Marcos are telling the mayor that he would look "weak" if he doesn't have a running mate when he declares. Others in the Duterte camp believe the reverse is true, that he can proclaim this desire to seek the presidency by his lonesome, because everyone already knows that two senators are aching to be named his vice presidential candidate.
Duterte's advisers tell me that the mayor himself hasn't categorically chosen either senator, diplomatically telling both (as much as someone like Duterte can be diplomatic, anyway) that he will support them both in their bids to run for vice president in the elections next May, after both visited him in Davao. This has apparently given Marcos and Duterte enough encouragement to declare that the mayor has chosen them both—an unlikely scenario, of course.
But Duterte is well-known for keeping his cards close to his chest, refusing to telegraph his moves even to his closest advisers. And he is also known to be fiercely independent and impervious to outside pressure, like what Cayetano is applying to stampede him into adopting the senator as running mate.
All of which will surely give both Marcos and Cayetano jitters as the filing deadline approaches. Let's see how this turns out.


text:
|Numéro de publication
|Type de publication
|Numéro de demande
|Date de publication
|10 janv. 2012
|Date de dépôt
|19 mars 2008
|Date de priorité
|19 mars 2008
|État de paiement des frais
|Autre référence de publication
|Numéro de publication
|Juan Qiao
|Cessionnaire d'origine
|Integrated Device Technology, Inc
|Exporter la citation
|BiBTeX, EndNote, RefMan
|Citations de brevets (7), Référencé par (1), Classifications (6), Événements juridiques (3)
|Liens externes: USPTO, Cession USPTO, Espacenet
1. Technical Field of the Invention
The present invention relates to a divider, and more particularly to a high frequency 3-phase-selection fractional-N divider.
2. Discussion of Related Art
Phase-Locked Loops (PLLs) find application in various context where a stable, often high frequency, clock signal is desired. Applications of PLLs include, for example, clock generation for CPUs and for telecommunications. Often, PLLs are required to operate at high frequencies.
PLLs often need fractional-N feedback dividers, especially some given fraction feedback dividers such as (N+⅓) or (N+⅔). A divide-by-(N+⅓) or (N+⅔) is often utilized in computer clock products, for example. However, general methods of implementing fractional-N dividers such as a sigma-delta arithmetic divider, for example, are complicated for a given fraction and may occupy a large number of logic circuits within an integrated circuit to implement.
Therefore, there is a need for fractional feedback dividers that are easily implemented and require fewer logic circuits.
In accordance with embodiments of the present invention, a divider that utilizes a plurality of phase clocks from a voltage-controlled oscillator (VCO) to realize a divided signal is presented.
A divider according to some embodiments of the invention can include a phase selection circuit that switches between a plurality of phase-separated clock signals in response to a switch signal to form a selected clock signal, the selected clock signal being utilized to generate a second clock signal; and a counter that receives the second clock signal and generates the fractional control signal and a transition control signal, the transition control signal indicating when the second clock signal should switch states in response to a transition of the selected clock signal, the counter generating a feed-back clock signal.
In some embodiments, the phase selection circuit provides the selected clock signal to a prescaler, which generates the second clock signal having a lower frequency that that of the plurality of phase-separated clock signals. In some embodiments, a plurality of high frequency phase separated signals are received by a plurality of high-speed prescalers, the plurality of high-speed prescalers generating the plurality of phase-separated clock signals, which are lower frequency that the plurality of high frequency phase separated signals.
A method of frequency dividing according to some embodiments of the present invention includes receiving a plurality of phase-separated clock signals; switching between the plurality of phase-separated clock signals in response to a switch signal to generate a selected clock signal; generating a second clock signal based on the selected clock signal; and generating the switch signal after N cycles of a high frequency clock signal.
These and other embodiments will be described in further detail below with respect to the following figures.
In the drawings, elements having the same designation have the same or similar functions.
In the following description specific details are set forth describing certain embodiments of the invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced without some or all of these specific details. The specific embodiments presented are meant to be illustrative of the present invention, but not limiting. One skilled in the art may realize other material that, although not specifically described herein, is within the scope and spirit of this disclosure.
As shown in
Although an example that illustrates three frequency-separated clock signals that are separated in phase by 120 degrees is specifically disclosed herein, in general any number of frequency-separated clock signals can be utilized in other embodiments of the invention. Further, the phase separation between the phase-separated signals is not limited to 120 degrees.
In operation, high-speed prescaler 15 switches from low to high in response to the signal FB_ctrl and on the rising edge of the signal phx_out. Low-speed programmable counter 16 counts through N cycles of ph1 switches the signal FB_ctrl at specified counts, and sets the feed back clock signal ffb when N is reached. As shown in
An example of PSP 18 is schematically illustrated in
A configuration of high-speed prescalers 15 a, 15 b, and 15 c is schematically shown as high-speed prescaler 15 in
As shown in
As shown in
The operation of high-speed prescaler 15 c (PRESCALER3) is explained below. A signal flag1 n shown in
When the state of high-speed prescaler 15 a changes from "001" to "011" at time T4, the signal flag1 n becomes logic "0". Consequently, the subsequent positive edge of signal ph1 at time T5 causes a signal flag1 to become "1" and a positive edge of a signal flag1 occurs at time T5. When the signal flag1 at logic "1" is input into a NAND 68, as shown in
Once activated, high-speed prescaler 15 c starts counting at the subsequent positive edge of signal ph3, which occurs at time T8 when a signal flag3 n becomes logic "1." High-speed prescaler 15 c transmits the signal ck3, which at time T8 is at logic "1." A positive edge of the signal ck3 at time T8 causes a negative edge of the signal clksum, which is transmitted from an inverter 65 c and subsequently supplied into an inverter 67. Then, inverter 67 provides a positive edge of the signal Clk_2 nd at time T8.
In a similar manner, high-speed prescaler 15 c transmits the signal flag3 n in accordance with state of high-speed prescaler 15 c, and activates high-speed prescaler 15 b in accordance with the signal flag3 and the signal s3. High-speed prescaler 15 b transmits the signal flag2 n in accordance with state of high-speed prescaler 15 b, and activates high-speed prescaler 61 a in accordance with the signal flag2 and the signal s1.
High-speed prescaler 61 a (PRESCALER1) is stopped in the fashion described below. When the signal flag1 becomes logic "1" at time T5, the logic "1" state of signal flag1 is input into a NAND 602, as shown in
As shown in
In a similar manner, high-speed prescaler 15 b transmits the signal flag2 n in accordance with state of high-speed prescaler 15 b, and is stopped in accordance with the signal flag2 and the signal s3. High-speed prescaler 15 c transmits the flag3 n in accordance with the state of high-speed prescaler 15 c, and is stopped in accordance with the signal flag3 and the signal s2.
As described above, high-speed prescalers 15 a, 15 b, and 15 c are alternately activated and stopped to transmit the signal ck1, the signal ck2, and the signal ck3 in turn. Thus, the phase selection units 66 a, 66 b, 66 c allow the signals ck1, ck2, and ck3 to be transmitted in turn.
As shown in
According to some embodiments, feedback divider 17 utilizes the three phase-separated clocks of the VCO to realize divide-by-(N+⅓) or (N+⅔) as a given fractional-N divider. Phase-locked loop (PLL) 10, shown in
For illustrative purposes, certain embodiments of the invention have been specifically described above. However, other embodiments are intended to be included within the scope of this disclosure. Therefore, this disclosure is not intended to be limiting to the particular embodiments described herein. The scope of the invention is therefore limited only by the following claims.
|Brevet cité
|Date de dépôt
|Date de publication
|23 mars 2001
|30 avr. 2002
|Nec Corporation
|Clock control circuit and clock control method
|7 sept. 2001
|15 juil. 2003
|Ge Medical Systems Global Technology Company, Llc
|System and method for ascribing times to events in a medical imaging system
|27 déc. 2001
|16 déc. 2003
|Applied Micro Circuits Corporation
|Embedded frequency counter with flexible configuration
|13 janv. 2003
|28 déc. 2004
|Seiko Epson Corporation
|Step-up circuits
|14 juin 2005
|24 mars 2009
|Sharp Kabushiki Kaisha
|PLL circuit and high-frequency receiving device
|28 aoűt 2006
|13 juil. 2010
|Nec Electronic Corporation
|Clock and data recovery circuit
|22 oct. 2007
|24 avr. 2008
|Chi-Kung Kuan
|Fraction-N Frequency Divider and Method Thereof
|Brevet citant
|Date de dépôt
|Date de publication
|15 sept. 2014
|24 mai 2016
|Thomas & Betts International, Llc
|Programmable slew rate phase locked loop
|Classification aux États-Unis
|Classification internationale
|Classification coopérative
|Classification européenne
|19 mars 2008
Owner name: INTEGRATED DEVICE TECHNOLOGY, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:QIAO, JUAN;REEL/FRAME:020742/0213
Effective date: 20080318
|10 juil. 2015
|Fee payment
Year of fee payment: 4
|5 avr. 2017
Owner name: JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT, NE
Free format text: SECURITY AGREEMENT;ASSIGNORS:INTEGRATED DEVICE TECHNOLOGY, INC.;GIGPEAK, INC.;MAGNUM SEMICONDUCTOR, INC.;AND OTHERS;REEL/FRAME:042166/0431
Effective date: 20170404


text:
5260 E Mason Lake Dr W, Grapeview, Washington
$550,0004 Beds2+ BathsPending Inspection
$550,0004 Beds2+ BathsPending Inspection
5260 E Mason Lake Dr W, Grapeview, Washington 98546 - Waterfront home on Mason Lake fully furnished with dock and usable boat house. Main house features a master bd with walk in closet and bth. Another bath and a bedroom with lake views. Wood fireplace with large windows and deck over looking the lake. There is a 2 bd / 1 bth apartment with a separate entrance with private deck above one of the two garages.. 4 bays total ,RV parking,shop and storage space. Home can sleep 14 comfortably. Come enjoy Mason Lake this summer.
Listing Courtesy of RE/MAX Top Executives


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Moog Music Inc.
by Moog Music subscribed to 5 years ago
22 Videos / 476 Followers
Welcome to the Moog Music Vimeo Channel.
These videos are a great way to learn how you can connect to the world of creativity and expression available with Moog musical instruments. Enjoy, and…
Channels are great for showcasing and watching groups of curated videos.
More stuff from Lstrengh80
1 Collection
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Kurt G.wrote a review of TIME ATAC XS Pedal on January 1, 2012
Great pedal
I second the other review that suggests this pedal is A) really, really great and B) clears mud like no other, except for maybe the flimsy, Crank Bros eggbeater-style pedals. I've not had any experience with servicing the pedal, but am comforted to read all of the reviews on mtbr and here that detail good experiences with that side of things. This pedal was my first clipless, and I must say, they're so easy to get in and out of. For those of you just getting into the game, don't bother with the platform/clipless hybrids. The platforms are quite the mental crutch and serve only to get in the way of getting into the pedal. Obviously, just my opinion.
One small issue, I went from one shoe to another, using the same cleat and for about 5 rides, I experienced about 1mm of play on my right pedal. It has since disappeared, but if you read more reviews, you'll see others have had this problem, as well.
If you can pick these up on CL for around $100, they're an absolute steal. If not, get 'em anyway!


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Cape Town - The mining industry had itself to blame for oversupply in the market, Anglo American's chief executive said yesterday, and could not rely on a reversal of the commodities price slump anytime soon.
In his first public appearance since revealing an audacious turnaround plan in December, Mark Cutifani, told a conference in Cape Town that this year was looking like the "most challenging yet" for the industry.
Read: Safety in focus at Mining Indaba
"We can't rely on a reversal of this price slump anytime soon. 2016 is already shaping up to be the most challenging yet. Opinions are divided on whether we have reached the bottom of the cycle… So things may still get worse before they get better," he said.
Cutifani said for some producers, adjusting supply to align with decreasing demand growth might not make sense as they sought to maintain market share and drive competitors out of business. "This strategy generally has a net negative effect," he added.
Anglo announced plans in December to whittle down its business to cope with severe falls in commodity prices. The plan involves offloading three-fifths of its assets.
"We will be making the appropriate commercial decisions to exit a number of our mines in several countries around the world – but let's not see that as a negative step," Cutifani told the gathering.
"For the assets that we choose to exit, it is about giving many of them and their employees a more sustainable future under new ownership that is better suited to focus attention and capital on those assets," he said.
Anglo American is expected to give more details about its future portfolio alongside its annual results next week.
Anglo and Cutifani have faced criticism for moving too slowly on an overhaul that has been derided by some as too vague and lacking the urgency required in the current "doomsday" environment.
Broken up
"Either that value is unlocked by Mark Cutifani, or Anglo gets taken out or broken up," said Paul Gait, a mining analyst at Sanford C Bernstein, who used to work in corporate finance at Anglo American.
"The question now is which will manifest itself first: a successful execution of Cutifani's restructuring plan, or an exhaustion of shareholder patience to tolerate Anglo American in its current form?"
While the Australian chief executive talked of "grim" markets, job losses and abandoning businesses for years, it has turned into a question of survival as he tries to salvage a century-old company from the wreckage of over-expansion funded by billions of dollars of debt.
Anglo, once South Africa's biggest company, is among the largest and most high-profile victims of the commodity collapse. Weighed down by borrowing and with too many mines that don't make money, it has become the canary in the coal mine for an industry trying to figure out when it will hit the bottom.
It was the worst performer in the UK's FTSE 100 index last year. Even after a 45 percent rally last week as commodities prices picked up, the company's stock market value is still down at $6.8 billion (R108.9bn), a little over half its $13bn of debt.
Cutifani has outlined an ambitious, if so far sparse, plan to turnaround its fortunes. The aim is to cut loose more than half of the company's mines, shedding those that lose cash, to become a much smaller business. It will be centred around its dozen or so most lucrative assets: they include diamonds, through its De Beers unit, copper and platinum.
In a market awash with unwanted mines, investors say the company must deliver quickly. "There has to be some movement in terms of sales," Norman Mackechnie, a fund manager at Momentum Asset Management, said. "The big issue is reducing debt."
Anglo has already made some progress on sales, with tarmac assets, copper mines in Chile and marginal platinum operations in South Africa raising about $2bn last year.
Since December, when Anglo revealed its dramatic downsizing, the company has also offloaded coal mines in Australia.
The next target is to raise $4bn. For sale are assets related to coal, platinum, copper and niobium – a mineral used in alloy metals.
The future of its iron ore mines, including the Minas Rio in Brazil that cost $14bn to buy and build, remains uncertain.
More businesses are likely to be put on the block when the company reports full-year results later this month. Anglo's biggest challenge will be finding buyers.
Should Anglo's asset sales fail to gain traction, Cutifani will have to go back to the drawing board.
Getting money from the stock market may be challenging, with two of Anglo's biggest shareholders reluctant to back such a move after the price collapsed 75 percent last year.
Raising money
RBC Capital Markets says the $5bn the company may need to raise is more than the market can stomach.
More likely, Anglo American could consider selling one of its best assets, according to Mackechnie. That could include part of De Beers or some of its copper assets, RBC said.
Bank of America Merrill Lynch said it could raise between $2bn and $4bn selling its stake in the Collahuasi copper mine in Chile. Anglo's share price closed 2.13 percent up at R84.50 on the JSE yesterday.


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Carl Sims
Carl SimsBUY CDS
Carl Sims began performing when he was sixteen years old singer for the Original Bar-Kays back in the mid-60s. The Bar-Kays took Arthur Conley's place as opening act for the Otis Redding Revue. A plane crash in Milwaukee, Wi. in 1967 killed Otis and several of the Bar-Kays. Carl along with James Alexander the Bass Player for the group luckily took a commercial flight out of Cleveland, OH to join the group in Milwaukee, because there was no room on Otis's private plane. Carl remembers, having to identify the bodies of the Band members. After returning to Memphis along with the surviving members Ben Cauley (Trumpet player) and James Alexander what was left of the Bar-Kays went there separate ways.
Carl began his solo career with a couple of Hits "Trapped" and "17 Days of Loving", on Paula-Jewel Records. From there he went to Malaco Records for two albums, one for Entune and now he is with Ecko Records.
Album Discography
"House Of Love" (Paula 1995)
1. Shot to the Curb
"Let Me Be The One" (Waldoxy 1998)
1. Standing in the Background
"M & M Man" (Waldoxy 2001)
1. I'm Gonna Tell My Wife (And My Woman Too)
"Brick House" (Entune 2003)
1. Brick House
2. When Something Is Wrong With My Baby
3. I Never Had a Lover Like You
4. Where Can I Run To
5. Our Love Song
6. Don't Make Me Cry
7. Burning Candles on Both Ends
8. Beggin Baby
9. Everything's Out in the Open
10. House of Love
"It's Just A Party" (Ecko 2004)
1. It's Just a Party
"I'm Ready" (Ecko 2006) LISTEN
1. I Needed a Woman
"Can't Stop Me" (Ecko 2007) LISTEN
1. If You Can't Help Me
"Hell On My Hands" (CDS 2011) LISTEN
1. Hell On My Hands
"Soul Singer" (Soul Singer 2014) LISTEN
1 Are You Serious
"The Best Of" (Ecko 2014)
1 It's Just a Party


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Yundi Li: 'I Think I'm Not a Normal Artist'
The Independent profiles pianist Li Yundi, who has not taken the spotlight of his contemporary Lang Lang, but is equally admired in the classical music world:
As the son of a steel worker in provincial Chongqing, Yundi Li was born into a world permeated by Chinese folk music and pop, but at the age of three, he was suddenly entranced by the sound of an accordion. His parents bought him one, and two years later he won a competition with it. Then he chanced to hear someone practising the piano. "I had never heard a piano before," he says. "And this sound, with its rich range of colour, was instantly very special for me. I hung outside the window for half an hour, drinking it in."
His words tumble out quickly and eagerly, with self-deprecating charm. The contrast with Lang Lang – for whom an interview is a tiresome formality prior to the more serious business of a photo-shoot – could not be greater.
Had he been raised in Britain, Lang Lang would have been put on the abused-child register for the way his raveningly ambitious father treated him – throwing his toys out of the window when he was five, and at one point ordering him to jump to his death from a balcony when he'd been rejected by a teacher. Yundi Li's parents, on the other hand, were devotedly supportive: his mother gave up her job to look after him while he studied at the Sichuan conservatory, but she and his father seem to have put him under no pressure: "They just tell me to enjoy my life." He stayed from eight to 18 with the same teacher, Professor Dan Zhaoyi, during which time he won a string of competitions, including the Stravinsky Youth Competition when he was 13, the Utrecht Liszt competition at 17, and the Warsaw one the following year.
Video: Yundi Li perform's Chopin's Nocturne No2
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Black Petite Sassy Suckers Lollipops ~ 400 Count
|Individually wrapped, black and white striped. These petite Sassy Suckers are great for parties and candy buffets. Curved black lines stretch across the hard candy's surface and meet in the centers on the left and right sides. A handy 2-inch stick makes this confection a perfect treat. These lollipops have a wonderful cherry flavor.
.5" in diameter with a total length of 2.5"
There have been no reviews


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Danger Signals in Cardiovascular Disease
Call for Papers
Cardiovascular disease is the leading cause of mortality and morbidity in Western societies and imposes an ever-growing socioeconomic burden to healthcare systems. Whether it is the rupture of a vulnerable atherosclerotic plaque or adverse myocardial remodeling after ischemic injury, inflammation is one of the key mediators of cardiovascular complications. In the absence of pathogens, the activation of innate or adaptive immunity in cardiovascular disease is intriguing. Endogenous signals released after tissue injury, also referred to as Damage/Danger Associated Molecular Patterns (DAMPs), may activate the same receptors involved in pathogen recognition. Matricellular proteins, oxidized lipid particles, and cytoskeletal proteins are a few examples of DAMPs that trigger inflammation. Elucidating the interaction between DAMPs and both innate and adaptive immunity can help us to dissect the complex inflammatory cascade in cardiovascular disease. A better understanding of the inflammatory response may result in improved therapeutic strategies, since previous anti-inflammatory agents were not successful or even detrimental in patients.
We invite authors to submit review and/or original research articles that seek to define the role of DAMPs in innate and/or adaptive immunity after cardiovascular injury. Research areas may involve ischemic heart disease, heart failure, atherosclerosis, or other research fields associated with cardiovascular disease (e.g., rheumatoid arthritis, cardiotoxic agents). Articles that are particularly of interest include, but are not limited to, those using human subjects and animal models for cardiovascular disease. In vitro experiments studying endogenous molecules that trigger inflammation are also welcome. Potential topics include, but are not limited to:
- Toll-like receptor, NOD-like receptor, and receptor for advanced glycation end products (RAGE) activation and signaling in cardiovascular disease
- The interaction between the extracellular matrix and inflammatory cells
- Cardiovascular imaging of inflammation
- Novel in vivo and in vitro models describing the role of DAMPs in cardiovascular inflammation and atherosclerosis
- Novel anti-inflammatory therapeutic strategies in cardiovascular disease
- Novel therapeutic or diagnostic targets within innate or adaptive immunity for cardiovascular disease
- The association between DAMPs and cell death (apoptosis, necroptosis, necrosis, and autophagy)
Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/mi/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/mi/dang/ according to the following timetable:
|Manuscript Due
|Friday, 4 October 2013
|First Round of Reviews
|Friday, 27 December 2013
|Publication Date
|Friday, 21 February 2014
Lead Guest Editor
- Fatih Arslan, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
Guest Editors
- Claudia Monaco, Kennedy Institute of Rheumatology, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, London, UK
- Stefan Frantz, Department of Internal Medicine I, University Hospital Würzburg, Comprehensive Heart Failure Center, University of Würzburg, Würzburg, Germany


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Artist description:
One of the main characters of the manga I'm writing ^^ (No I do NOT expect to get it published, I'm just doing it for fun, so lay off the discouraging comments.) I'm a better artist with a hand-held pencil, and i don't have a tablet :/ ENJOY! :D
Java Draw Created Nov 24, 2010 470 x 338px Unless noted Copyright 2010 12blue21.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
I wrote a manga just for fun, too. xD I always draw with a pen on paper. :) You never know if it might be published someday. :D I don't have a tablet either, or a computer. :/ I love how you dre his expression and his head band. He looks awesome! 5/5


text: About Sassy PaintsWe are now Sassy Paints!!! Nothing has changed but our name... same great location, same fabulous artists, and same owners! Please make note that our new website is www.sassypaints.com. We look forward to continuing to share and paint with all of you!!! See you in the studio soon!!!


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The Friends of Fort Yargo State Park in Winder will host a live wildlife demonstration featuring native and exotic animals from 6 to 7 p.m. April 21.
The event is presented by Earthen Excursions at the amphitheater in the campground. The fee is $3 plus $5 parking.
For information call (678) 963-8891.


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Jorge Cham's Ph.D. Comics have been a hit with graduate students and people from around the world, so much so that a movie was created based upon his work. His comics capture moments that are familiar to nearly all Ph.D. students.
Sometimes maybe even a little too familiar.
Have you ever wondered what happens at the heart of a dissertation defense? This is the final oral test that a doctoral student must pass before officially receiving the Ph.D. Certainly it strikes fear in the hearts of many graduate students.
But have any graduate students ever put their heart to the test?
It turns out that my colleague Greg Park actually did. Before starting his defense, he wired himself with a Garmin Forerunner 305 to monitor his heart rate during the event. You can find the entire post on his blog here which I highly recommend.
Like any respectable scientist, Greg published his results:
It turns out his heart rate was lowest when the projector broke before the defense began, and highest just as his committee began testing him with questions. Perhaps some of the minor peaks in the middle of the graph were difficult questions.
So it turns out that the Garmin isn't just for running, it can also be used to see how anxious you are when you publicly speak. I don't know about you, but I have the feeling that if I wore a Garmin when I was at my dissertation defense, my heart rate graph would have a lot more curvature.
What do you think yours would look like?
© 2013 by Jonathan Wai
You can follow me on Twitter, Facebook, or G+. For more of Finding the Next Einstein: Why Smart is Relative go here.


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This is just came with the memory of Salam 98 ,it can become another Egyptian X-file : The missing Badr I.
Badr I is a 1700 ton cargo ship owned by Afro Asia Shipping company "I do not know if it was the one from Singapore or it is a native company", its crew consists of 14 men on board of the vessel : 9 Egyptians , 4 Sudanese and one Yemeni. The flag on the ship is the flag of Sierra Leone !!
In last January 2008 this cargo ship went from the Suez to Port Sudan harbour to deliver a cement cargo there . Badr I according to the owner of company was complied with all safety measures and all licenses . The voyage between Suez and Port Sudan is about 800 miles.
From more than 17 days ago the ship was supposed to show up at Port Sudan but it did not , it was reported to be missing in the red sea till now . We can't find it nor can the Sudanese , it suddenly disappeared , we do not know till now it was sunk or not , the Port Sudan harbour authorities reported that they did not receive any distress message signal through the GPS device or SOS message signals. The ship was disappeared after 3 days only from its departure from Suez. The families of the crew began to answer questions and unfortunately the authorities for real do not have any answer , our Navy sent search and rescue time hoping to solve the riddle , yes the weather was bad during the past couple of weeks still it is strange that a ship suddenly disappear from the monitors with no trace .It could not be completely sunk 100% .There could be something in the Ship that made its GPS stop working and thus it can't send any signals and no one can see it. The ship can be a victim of piracy ,yes there are modern piracy but not the type of Captain Jack Sparrow , still Piracy does not exit in that location in the red sea, there are pirates in other parts of the red sea but no this one , also if the pirates attacked the ship ,they would connect the company for the crew ,it would be a hostage situation then !! But nothing for 3 weeks was announced .
The Captain of the Ship is called "Sabri El-Battouty" ,I do not know if he is related to Captain "El-Battouty" of the famous air Egypt flight 767 which crashed in NY from couple of years ,if he is well it would be a strange irony , a curse that is following the "El-Battouty" family. His son "Islam" told weekly magazine "Akhar Sa' " that his father works in the sea for 40 years and that he called the family on that last 12th of January saying that the ship was facing some trouble and that he found out that the fuel was mixed with Water !! Already captain Sabri joined the crew only month ago and on the 6th of January 2008 he called his family and told them that he was thinking not to sail with Badr I due to the way they handling the cargo with and the old age of the ship .
Oh yes the ship is old ,very old , it is 40 years old !! And listen to this , the ship has no insurance because of its old age,the insurance companies refused to insure it !!
The surprises are not finished yet ,it turned out the company did not send any plane to search for the vessel except after 17 days !!
The company is saying that the last connect with the ship was on the 12th of January , where as the foreign ministry says that the last connect was on the 29th of January !!?? The life of 14 persons are in danger , their families are waiting and I feel that it is going to be one hell of riddle .it is great to find that the Egyptian media is following the case till now . I think there is something fishy concerning the company, the owner of the ship . This is a clear carelessness case , the company is careless for sure because there is no Bermuda triangle in the red sea
Updated on the 14th of February the Ship was found safely thank God in front of the Sudanese shores,thank Goodness the crew is alive ,it had a malfunction in front of the Lebanese shore , it is not an Egyptian X-file , it is solved thank Goodness
Another Update on the 12th of April 2008 , it has not been found yet


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When Ole Miss coach Andy Kennedy was getting his team ready to hit the road against No. 1 Kentucky, he figured he had enough to talk about before mentioning the Wildcats' home win streak.
Well, the Wildcats' streak reached 50, after No. 1 Kentucky beat the Rebels 77-62 on Saturday.
"We talked about a lot of things, and that wasn't one of them," Kennedy said. "I didn't want to bring that to our guys' attention. For us, it was really about competing. They have done such a tremendous job."
Terrence Jones had 15 points and 11 rebounds to lead No. 1 Kentucky to a 77-62 victory over Mississippi on Saturday, the Wildcats' 50th consecutive win at home.
The Wildcats (26-1, 11-0 Southeastern Conference) are 49-0 at home under head coach John Calipari as part of the nation's longest active home winning streak.
Instead of stopping Ole Miss (15-11, 5-7), Anthony Davis picked up two fouls early and was forced to the bench for much of the first half. Without Davis looming, who leads the country with 4.9 blocks per game, forwards Terrance Henry and Murphy Holloway took it to the rim while Kentucky forced up 3-pointers on the other end.
"We just felt like we had nothing to lose in this game," said Henry, who led all scorers with 18 points. "We just came out and played as hard as we could to give ourselves a chance to be in this game."
At one point in the first half, the Rebels led 31-29. But as soon as they did, Darius Miller tied the game back up with a soaring dunk over Reginald Buckner. The one-handed slam woke Kentucky's notorious home crowd back up, and the Cats went on a 14-3 run over the next two-and-a-half minutes.
Miller, a senior, is the only player or coach on Kentucky's bench that's been a part of all 50 games in the home win streak.
"It's a great feeling to be able to accomplish something like that at a program like this," he said. "I'm just happy and blessed to be a part of something like that. It was kind of a struggle my first year here, and the way that it changed so quickly-I'm just blessed to be a part of it."
The last time the Wildcats lost a home game was March 4, 2009. Billy Gillispie was the head coach, and Kentucky lost 90-85 to Georgia.
Kentucky took an early 16-5 lead, but the Rebels took advantage of Davis sitting for much of the first half because of foul trouble. Ole Miss forwards Terrance Henry and Murphy Holloway took the ball inside without the nation's leading shot blocker looming. Henry, who had 16 points of his 18 points in the first half, helped the Rebels (15-11, 5-7) take a 31-29 lead.
But the Wildcats hit three straight 3-pointers to take a 43-35 halftime, and they never trailed in the second half.
The double-double was Jones' first of his sophomore season after recording 13 as a freshman.
As Ole Miss was taking the ball inside before halftime, the Wildcats were settling for outside jumpers that initially weren't falling. But Kyle Wiltjer and Miller came off the bench and started hitting shots. Both players had 10 points at halftime, and the hot shooting carried over to the second half. Kentucky finished the game shooting 10 of 18 from 3-point range.
Holloway had 15 points for the Rebels.
Doron Lamb had 16 points for Kentucky, while Miller had 14, Wiltjer 13 and Davis added 10 points, six rebounds and four blocks in 25 minutes.
Ole Miss coach Andy Kennedy said this year's Kentucky team is the best he's faced in his six years of coaching in the Southeastern Conference, and he spent his energy preparing his team for that instead of the home win streak.
He did tell his players to enjoy the atmosphere, though.
"I'm a basketball jones at heart, so I have great respect for this place and the passion. To me, it's the pinnacle. It's the pinnacle of college basketball," Kennedy said. "For our young guys, sometimes I want them to understand the opportunity. Very few times do you get the chance to play in Rupp Arena in front of a packed house against the No. 1 team in the nation, so enjoy it."


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February 2002, is the month and year that Al Gore came back from the political graveyard. After losing his home state of Tennessee in the last election, I anticipated he'd move to Palm Beach, Fla., and look for butterfly chads. Instead, the bearded Al Gore is back, commenting on the way he would run things. Does anyone in their right mind really care what one of the many Al Gores has to say?
more Hamby columns
The new facial hair is perhaps blocking Al Gore's old political judgment. More likely, he has been bitten by the political bug and thinks that he can win this time. The political bug can produce a strong toxin. Our own Commissioner Hugh Logan notes that the only way to be cured is to be embalmed.
Former Speaker of the House Tip O'Neil coined the phrase, "All politics is local." So, let's examine what is happening in our own little town since we last tuned in.
It seems as though Linda Ford will not run for reelection as District Seven commissioner this year. That is too bad. Linda has been a commissioner who combines intellect with common sense to get things accomplished for her district. Linda wants to spend more time with her family and attend to her business.
My guess is she's really leaving the commission because of a new Carl Jordan initiative to conduct the commission meetings without any lights. It seems as though the glare from the lights makes it hard for Jordan to read the government memos and recommendations. You can't blame Linda for not wanting to be in the dark with Commissioner Jordan.
Kathy Hoard has announced her intentions to run for the seat being vacated by Linda Ford. Kathy used to come into the restaurant where I worked while I was in college, and we would sometimes get into discussions about Athens and its politics. During these conversations, her husband Ed would sit quietly, occasionally nodding as something was said that he agreed with. I got the impression that Ed was more interested in who was winning the latest golf tournament rather than who was winning public opinion. Or, it could have been that he wanted to eat his meal without being bothered by the political waiter.
Kathy and Linda may not share the same political ideology, however, what's more important is that they share a common sense approach in addressing local issues. Kathy served on the old Athens City Council, and her willingness to come back and be a part of the unified government will benefit Athens.
Speaking of someone who needs to venture back to the political landscape, Tal DuVall would be a good representative for the Athens area under the gold dome in Atlanta. I ran into Tal at Sam's Warehouse last weekend. If you shop at discount places, it is a good indication you are like most people who are looking for a bargain. Tal knows how to find a good deal, and his bargain skills are something we could use in Atlanta.
This political season will be a long one. Many surprises may occur that will make for good entertainment for those spectators with the political bug. Our show, "As Athens Turns," will see the return of former political participants, and it will also showcase new talent. Future episodes will place the developer against the environmentalist, the hardware politician against the lawyer, and the insurance executive-turned mayor against former government antagonist. Stay tuned; "As Athens Turns" will be back after these brief messages.
Mike Hamby is an Athens resident and a manager for a local beer and wine distributor. He can be reach via e-mail at email@example.com.
Published in the Athens Banner-Herald on Saturday, February 16, 2002.
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