text:
|Número de publicación
|Tipo de publicación
|Número de solicitud
|Número de PCT
|Fecha de publicación
|28 Dic 2010
|Fecha de presentación
|25 Mar 2005
|Fecha de prioridad
|30 Mar 2004
|También publicado como
|Número de publicación
|Alexander Thomas Jacobs, Jared Alden Judson
|Cesionario original
|Eli Lilly And Company
|Exportar cita
|BiBTeX, EndNote, RefMan
|Citas de patentes (62), Citada por (14), Clasificaciones (13), Eventos legales (2)
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet
This is the national phase application, under 35 USC 371, for PCT/US2005/010205, filed 25 Mar. 2005, which, claims the benefit, under 35 USC 119(e), of US provisional application 60/557,545, filed 30 Mar. 2004.
The present invention pertains to medication dispensing devices, and, in particular, to a portable medication dispensing device such as an injector pen.
Patients suffering from a number of different diseases frequently must inject themselves with medication. To allow a person to conveniently and accurately self-administer medicine, a variety of devices broadly known as injector pens or injection pens have been developed. Generally, these pens are equipped with a cartridge including a piston and containing a multi-dose quantity of liquid medication. A drive member, extending from within a base of the injector pen and operably connected with typically more rearward mechanisms of the pen that control drive member motion, is movable forward to advance the piston in the cartridge in such a manner to dispense the contained medication from an outlet at the opposite cartridge end, typically through a needle that penetrates a stopper at that opposite end. In disposable pens, after a pen has been utilized to exhaust the supply of medication within the cartridge, the entire pen is discarded by a user, who then begins using a new replacement pen. In reusable pens, after a pen has been utilized to exhaust the supply of medication within the cartridge, the pen is disassembled to allow replacement of the spent cartridge with a fresh cartridge, and then the pen is reassembled for its subsequent use.
One known type of injection pen uses a pull/push sequence applied to an externally accessible plunger member to deliver medication from the pen. The pulling of the plunger member in an axial, proximal direction first cocks or arms the pen for dose delivery, and then the axial pushing of the plunger member in the distal direction advances the cartridge piston to dispense the medication. While useful, such devices are not without their shortcomings. For example, some users who possess limited hand strength may find it difficult to apply sufficient force to push in the plunger member to inject a dose. In addition, the short plunger member travel associated with delivering very small doses in some pens may cause some users to question whether in fact a pen is operating to delivery the expected relatively small dose.
A number of injection pens are disclosed in International Publication No. WO 03/080160, the disclosure of which is incorporated herein by reference. These injection pens are advantageously designed with a mechanical advantage to allow lesser required plunger forces and greater plunger travel. However, when such pens offset the gear set from the axis of the cartridge, an asymmetrical injection pen may result if the overall pen size is minimized as is often desirable. Still further, the high mechanical advantages afforded by such pens may, under certain operating conditions, result in high forces being experienced by the internal gears or other components, which therefore may need to be made more robust to account for such forces.
Thus, it would be desirable to provide an apparatus that can overcome one or more of these and other shortcomings of the prior art.
In one form thereof, the present invention provides a medication dispensing apparatus including a housing, a drive member within the housing and movable in a distal direction, a fluid container defining a medicine-filled reservoir with a movable piston at one end and an outlet at the other end, the piston being engageable by the drive member to be advanced toward the outlet when the drive member is moved distally, a plunger movable relative to the housing from a distal position to a proximal position, the plunger manually pushable relative to the housing in the distal direction to be shifted from the proximal position to the distal position, means for interconnecting the drive member and the plunger to convert motion of the plunger from the proximal position to the distal position into a lesser amount of motion of the drive member in the distal direction, the interconnecting means including a gear set including a first pinion in meshed engagement with a rack of the plunger and a second pinion in meshed engagement with a rack of the drive member, and wherein at least a portion of the drive member extends through an opening through at least one of the first and second pinions.
One advantage of the present invention is that a medication dispensing apparatus can be provided which is internally configured to utilize space efficiently to allow for a compact design that contributes to a small and symmetrical design of the apparatus.
Another advantage of the present invention is that a medication dispensing apparatus with a gear set can be provided in which a gear that does not fully revolve during use may be modified to eliminate extraneous gear teeth and accommodate passage therethrough of another component, such as within the plane of the provided gear teeth.
Still another advantage of the present invention is that a medication dispensing apparatus can be provided with a force absorbing limiter to limit the forces experienced by other components of the apparatus during use.
Still another advantage of the present invention is that a medication dispensing apparatus can be provided which mechanically prevents a user from causing an injection prior to properly cocking the pen to deliver a complete dose.
Yet another advantage of the present invention is that a medication dispensing apparatus can be provided which assists the user in consistently delivering a proper dose.
The above-mentioned and other advantages and objects of this invention, and the manner of attaining them, will become more apparent, and the invention itself will be better understood by reference to the following description of embodiments of the invention taking in conjunction with the accompanying drawings, wherein:
Corresponding reference characters indicate corresponding parts throughout the several views. Although the drawings represent embodiments of the present invention, the drawings are not necessarily to scale, and certain features may be exaggerated or omitted in some of the drawings in order to better illustrate and explain the present invention.
Referring now to
The apparatus, generally designated 20, is shown as an injector pen, which pen has an elongated, substantially writing instrument-like form, although other forms are within the scope of the invention. Medication injector pen 20 is a disposable pen, in that after the quantity of medicine contained therein is exhausted by multiple operations of the pen, the entire pen is discarded rather than being reset and reloaded with a replacement container of medicine. Pen 20 is repeatably operable to deliver into a user a fixed dose, i.e., a dose in a specific amount that is dictated by the particular design of the pen. For the shown pen 20, that fixed dose is not settable by a user but rather is dictated by the pen manufacturer.
Injector pen 20 generally includes a distal portion 22 and a proximal portion 24. Distal portion 22 contains the medicinal fluid to be outlet at its distal end upon pen operation. The outlet end of distal portion 22 is equipped in
The injecting mechanism housing is formed from a lightweight and opaque material, such as injection molded plastic, in two longitudinally extending halves 30 and 31. The housing halves 30 and 31 are aligned via mating pins and recesses provided therein and fixedly secured together during manufacture, such as via adhesives or ultrasonic welding. The injecting mechanism housing is somewhat elliptical in transverse cross-section to provide flatter regions in its circumference that aid in preventing pen 20 from rolling when placed upon a planer surface, and to accommodate the injecting mechanism in a limited volume form. The non-cylindrical tubular body of housing halves 30 and 31 defines an internal hollow 32 (See
Distal portion 22 includes a retainer that holds a cartridge 48 therein. The cartridge retainer is shown formed in part as a distal extension of the plastic housing for the injecting mechanism of the pen, and in additional part as a stepped-down plastic cap 34 that is fixed securely during manufacture, such as via adhesives or ultrasonic welding, into the housing extension distal end. Although cap 34 is shown, for example, in
With reference to
Cartridge 48 is of conventional design and defines a medicine-filled reservoir 50 that is closed at its proximal end by a piston 52 that is axially slidably and sealably engaged with the cartridge interior wall to hold the fluid medication within reservoir 50. The distal, outlet end of cartridge reservoir 50 is sealed by a septum 54 held by a cap 56 that is secured to a stepped-down diameter neck portion 49 of the cartridge. When pen-needle assembly 38 is mounted on retainer cap 34, the proximal point 43 of injection needle 40 penetrates cartridge septum 54 to provide a fluid flow outlet by which medicine within cartridge reservoir 50 can be dispensed from needle tip 42 during operations of injector pen 20. Cartridge 48 is sandwiched between the interior surface of cap 34 and an internal shoulder provided on housing halves 30 and 31 to prevent axial movement of the cartridge during use. Other manners of capturing the cartridge relative to the housing may alternatively be employed.
The fluid medicine container shown and described above is illustrative and not intended to be limiting as other constructions may be employed within the scope of the invention. For example, rather than the shown container in which a distinct cartridge is held via a cap within a retainer region of the pen housing, in another fluid container embodiment, the cartridge could be constructed to be sufficiently durable and adapted to secure directly to a pen proximal portion 24 without any protective retainer region therearound, and with the pen-needle assembly directly mountable to the cartridge. Still further, the cartridge could be held in a retainer distinct from the pen housing, which cartridge/retainer assembly is, in the case of a disposable pen, fixedly mounted or secured, via adhesives, ultrasonic welding or in another suitable manner, to a previously subassembled pen proximal portion 24 when injector pen 20 is assembled by the manufacturer, or, in the case of a reusable pen, removably mounted or secured, such as via a threaded connection, to a reusable pen proximal portion 24 having a resettable drive member.
With additional reference to
Drive member 60 is formed in the shown embodiment of a multi-part construction including a foot 66, a cartridge-engaging piece 68 and a pinion-engaging piece 70. Foot 66 is disc-shaped and during manufacturing assembly is snap-fit to the distal end of drive member piece 68. Drive member piece 68 extends axially, has a square rod-shaped body, and during medicine injecting causes movement of the cartridge piston that it engages via the foot, which piston movement is the same in distance and direction as its movement. Foot 66 has a larger surface area than the transverse cross-sectional area of drive member piece 68 to distribute loading on the cartridge piston 52 that foot 66 contacts and thereby directly engages during piston advancing.
Drive member pieces 68 and 70 are constrained by the internal shaping of housing halves 30 and 31 to be axially translatable and rotatably fixed therein. Cartridge-engaging piece 68 is movable in the distal direction and prevented from proximal movement relative to the housing halves, while pinion-engaging piece 70 is clutchably connected to cartridge-engaging piece 68 to be moveable relative thereto in a proximal direction but not the distal direction. To provide for these one-way axial motions, ratchets are employed in the shown embodiment, but other elements may be used. For example, a hard but compliant toothed member or members, such as made of metal, may be provided in tight engagement with a smooth, such as cylindrical, and relatively soft member lacking surface features, which metal tooth/teeth are arranged such that motion of the other member in only a single direction is permitted, as in the opposite direction the tooth/teeth dig into and deform the relatively soft surface to create a wedging action that impedes further motion in that direction.
In the shown embodiment, cartridge-engaging piece 68 includes a row of ratchet teeth on each of its four sides, which teeth continue uninterrupted along a portion of its axial length. The axial positioning and length that each row of teeth must span along its respective side is a function of the various pawls' positioning and intended use, such as the total injection volume and number of discrete injections, of pen 20. Rows of ratchet teeth 73 a on opposite sides of drive member piece 68 have a one-way ramping and are engaged by a pair of diametrically opposed resilient tabs or pawls 75 extending inward from the housing near the distal end of proximal portion 24. The resilient pawls 75 slide along and over teeth 73 a when drive member piece 68 is advanced distally during use, but abut the transverse, proximal face of teeth 73 a to prevent drive member back-up in the proximal direction.
Rows of ratchet teeth 73 b on the other two sides of drive member piece 68 are also provided with a one-way ramping similar in direction to the ramping of teeth 73 a, and are engaged by a pair of diametrically opposed resilient pawls 77 on pinion-engaging piece 70. As described further below, pawls 77 slide along and over teeth 73 b when pinion-engaging piece 70 is moved proximally during pen cocking, but abut teeth 73 b during the distal advancement of pinion-engaging piece 70 during injection, which abutting results in pinion-engaging piece 70 shifting distally cartridge-engaging piece 68. The pitch or distance between the transverse face of each adjacent tooth 73 b preferably is the distance piston 52 needs to be advanced to deliver the pen's fixed dose. And, while teeth 73 a are shown as being equal in length to teeth 73 b, teeth 73 a could be an integer multiple shorter.
Drive member piece 68 is shown as being integrally provided with its ratchet teeth 73 a and 73 b, such as by being made of a one-piece plastic injection molding, or a one-piece metal part. Other constructions of drive member piece 68, such as an assembly of separately formed component parts, are within the scope of the invention.
Although two pawls 75 and two pawls 77 are shown, each integrally formed with the housing or the drive member piece 70 as applicable, different numbers of pawls, including as few as a single pawl for anti-backup and a single pawl for advancement which cooperate with one or more rows of ratchet teeth, may be provided, and further the pawls may be separately formed and then tied to the housing or drive member piece 70 as applicable to be longitudinally fixed relative thereto.
Pinion-engaging piece 70 includes a pair of laterally spaced, longitudinally extending racks 80. Racks 80 are provided along an interior surface of the body 82 of drive member piece 70. Pawls 77 resiliently extend from body 82, and pawls 77, body 82 and racks 80 are integrally formed from an injection molded plastic, although other constructions may also be suitable.
To minimize the diameter of pen 20, this rack member and other rack members can be of such a small size that the base of the teeth of the rack is provided with openings through the rack member to accommodate the radial outer extent of the teeth of a pinion with which it meshes.
As further shown in
Plunger member 64 allows a user to control the internal gear set of the apparatus to prepare pen 20 for injection, as well as to effect the injection. In the shown embodiment, plunger member 64 is formed of a multi-piece construction, including an input element 90, a button 92, a button cap 94 and a force limiting biasing member 96.
Button 92 is molded from plastic and has an open proximal end in which a plastic button cap 94 can be snapped, glued, ultrasonically welded or otherwise fixedly attached in a conventional manner. A grip portion 98 of button 92 extends proximally of housing halves 30 and 31, even when apparatus 20 is arranged in a ready-to-be-cocked position. Grip portion 98 is externally accessible to be manually pulled by a user for pen cocking purposes. Grip portion 98 is shown as having an outwardly flared knob shape so as to be more readily grasped by a user, such as between the thumb and fingers of a user, when pulled to the right from the perspective of a viewer of
A tubular portion 100 of plunger button 92 extends distally from grip portion 98 and telescopically fits within housing interior hollow 32 so as to be slidable into and out from such hollow during use of pen 20. Tubular portion 100 is generally elliptical in transverse cross-section and conforms closely to the housing shape at its distal end such that button 92 is rotatably fixed with the housing. Flanges 101 and 102 extend from the proximal end of tubular portion 100. The outward faces of flanges 101 and 102 include curved ribs 104 and 105 that, during pen cocking, abut inward lips 106 and 107 formed into the distal ends of housing halves 30, 31 to limit withdrawal of the plunger member from the housing. An indicating band 109 that rings tubular portion 100 visibly projects beyond the proximal end of the pen housing when plunger button 92 has been fully withdrawn to properly cock pen 20, as shown in
The inward face of plastic plunger element 90 includes a rack 91 that, similar to fixed rack 88, works in conjunction with larger diameter pinion 114 of gear set 62. The shape of plunger element 90 and the hollow interior of tubular portion 100 accommodate the proximal end of drive member piece 68. The outer periphery of plunger element 90 is non-circular and fits closely within the correspondingly shaped housing halves to aid in preventing plunger rack rotation during use.
Axially extending within the central bore of plunger button 92 is a force limiting biasing member 96 provided in the form of a metal, helically coiled compression spring. Other suitable biasing elements may alternatively be employed. During pen manufacture, spring 96 is captured within button 92 with one spring end in abutting contact with the proximal face of shoulder 115, and the other spring end in abutting contact with the distal face of button cap 94 around centering hub 95. Spring 96 is so captured in a pre-stressed, or partially compressed, state. The extent of the pre-stressing is at least as large as forces the manufacturer expects users to apply on the plunger button during normal plunging to achieve proper pen operation. In one embodiment, the pre-stressing is in an amount of 1.2 pounds. Thus, during normal plunging, the spring does not further compress and the button 92 and input element 90 shift as a unit and without relative axial motion. Coil spring 96 is also designed with sufficient spacing in its coiling, and with proper elastic properties, such that the spring, by compression, can accommodate movement of button 92 from the cocked position, shown in
The gear set utilized in the injection pen is configured to convert plunger member motion of a first distance into drive member motion of a second distance less than the first distance. The gear set shown at 62 is made from a lightweight material such as plastic, and utilizes first and second sized pinions that can travel linearly as well as rotate, which linear motion can occur relative to all of the plunger, the drive member and the housing.
The larger pinion 114 is centered within the pen height and is flanked by a pair of smaller pinions 126 in the shown embodiment, but such an arrangement and number of pinions merely provides a well-balanced gear set and is not necessary to practice the invention.
The first or larger sized pinion 114 includes a discontinuous or interrupted ring of external teeth. Circumferential gaps between the toothed sections are formed by an opening 130 extending completely through the pinion diameter within the plane of the gear teeth, which plane is perpendicular to the axis of rolling rotation of the pinion. Opening 130 divides the first pinion into two arcuate sections of external gear teeth 116, one of which meshes with housing rack 88 and the other section meshes with plunger rack 91. Since the two arcuate sections of teeth 116 do not revolve into contact with each other's rack, these arcuate toothed sections need not have identical pitch and/or width, provided such sections have the same pitch diameter. Moreover, the non-circular shape of pinion 114 that results from opening 130 allows the overall axial length of the device to be reduced. Cartridge-engaging piece 68 can pass freely through opening 130 and does not interfere with the operation of the gear set as opening 130 replaces external teeth that are not needed due to the small angle of revolution of the pinion necessary for pen use, which small angle or partial roll is possible due to the high mechanical advantage possible with the gear design. The passage of the drive member through the center of the pinion allows apparatus 20 to be symmetrical about the cartridge axis and to have a compact design.
Pinions 126 have the same axis of rolling rotation as pinion 114 and each includes external gear teeth 127 arranged with a pitch diameter that is less than the pitch diameter of gear teeth 116. Gear teeth 127 meshably engage drive member racks 80, which racks 80 are parallel to plunger rack 91 but disposed on the opposite side of the pinion axis. As with the gear teeth 116 of pinion 114, gear teeth 127 are discontinuous as during use pinion 126 experiences but a partial revolution and therefore only a short arc of teeth to mesh with the rack are required.
Although pinion 114 and pinions 126 are shown integrally formed, these components can be separately formed and assembled together so as to be corotatable. In the shown embodiment, the pinions are formed as essentially being an open box in shape, but the pinions can be differently formed, such as C-shaped. Opening 130 does not pass through the plane of pinions 126 in the shown embodiment, but in alternate embodiments in which the relative positions of the pinions are switched, with corresponding switching of the racks, the opening could pass through the smaller diameter pinion.
In order to limit user misuse, pen 20 preferably includes a partial-cocking-preventing guide and follower. In embodiments where partial dosing is of lesser concern, such guide and follower need not be provided. The partial-cocking-preventing mechanism prevents an injection until the plunger has been manually shifted to the proximal or completely withdrawn position that corresponds to a fully cocked position of pen 20.
One suitable form of guide and follower is better shown in
Bar portion 140 includes an angled, distal end 142 and an angled, proximal end 144. The top face of bar portion 140 shown in
The follower 149 is associated with the plunger member and includes a pawl that cooperates with the ratchet teeth 150 to prevent distal movement of the plunger when the follower pawl is in engagement with the travel surface 148 via an abutting relationship with any one of teeth 150. In the shown embodiment, the follower pawl is in the form of a transversely extending pawl 152 that spans and is supported by resilient arms 154 that flank and distally project from the body of input element 90. Arms 154 and pawl 152 are integrally molded with the plastic input element 90, but may be otherwise formed.
Referring now to
When the plunger member is subsequently manually depressed for injection, the distal face of pawl 152 encounters and must be cammed upward by its engagement with proximal end 144 of guide bar 140, and the angled shape of shoulder 158 allows this movement. This camming upward provides an overcomeable resistance that may serve to limit unintended ejections of medicine. After the pawl is so cammed upward, it continues to slide along, and in the shown embodiment slides directly in contact with, travel surface 146. At this point, follower 149 and guide 139 are arranged as shown in
In some situations, it may be desirable to provide injection apparatus 20 with a feature that prevents use of the apparatus after a particular number of doses have been administered thereby, or when the medicine supply is exhausted. For example, for a therapeutic having a stated life of four weeks after the first puncturing of its cartridge septum by a pen-needle assembly, it may be desirable for a once-a-day injector pen loaded with that therapeutic to be disabled after the twenty-eighth injection is complete. To that end, any of a variety of mechanisms may be provided to prevent the plunger from being withdrawn, either at all or completely, after the twenty-eighth and "final" dose has been administered. Alternatively, and preferably if an alert were also included to notify the user thereof, the mechanism may cause cocking/plunging movement of the plunger to have no effect after the "final" dose is administered.
For example, in the embodiment abstractly shown in
In still other embodiments, different types of locking mechanisms may be employed to prevent use after the final injection. For example, the plunger element 90 may be physically locked, such as via a locking element, when cartridge-engaging piece 68 is driven distally to complete its final injection. For example, this plunger element locking feature may involve a spring-loaded locking element, mounted to the housing, that has a finger that slides along the proximal or untoothed portion of the body of drive member piece 68 during normal uses, which finger slides or falls off the proximal end of drive member piece 68 only during the administration of the final injection. This falling off of the finger allows the spring induced pivoting of the locking element to cause a portion of the pivoting locking element, or to cause the actuation of an additional locking element, to lockingly engage with a complementarily designed feature of plunger element 90
The structure of injector pen 20 will be further understood in view of the following explanation of its operation. Initially, a user requiring a dose of medication will locate pen 20, which pen is typically in the ready arrangement shown in
A pulling step is first performed to cock or prepare the uncocked pen 20 to deliver the dose for which it has been designed. During that pulling or withdrawing step, and while the pen housing and/or distal portion 22 is grasped in one hand, a user uses her other hand to pull plunger grip portion 98 axially away from the pen housing. Plunger grip portion 98 is to be pulled proximally a fixed distance, specifically until the proximal faces of plunger ribs 104, 105 abut the distal faces of housing lips 106, 107, which abutment halts the axial movement of plunger member 64 and at which time band 109 is visible.
During this plunger withdrawal, gear set 62 operates in the following manner. Pinion 114 is caused to roll proximally in meshed engagement with fixed rack 88 and rack 91, and consequently pinion 126 moves proximally an equal distance. This proximal movement of pinion 126 involves pinion 126 rolling in meshed engagement with drive member rack 80, during which time pinion 126 simultaneously pulls pinion-engaging piece 70 proximally relative to piece 68 held by pawls 75, as pawls 77 each slide along and ultimately snap over a ratchet tooth 73 b. The plunger member travel is designed such that the travel of the pinion engaging piece during a proper or complete pen cocking is just slightly greater than the spacing between successive teeth 73 b, such that the pawl is assured of passing over a single tooth.
To actually inject the medicine, after pen 20 is manipulated so the injection needle distal tip 42 properly penetrates, for example, a user's skin, an axial, distal plunging force is applied to force plunger 64 distally. As plunger 64 starts to move distally, the travel of rack 91 causes larger pinion 114 to begin to roll along fixed rack 88. Pinions 126 simultaneously begin to roll along drive member rack 80. Due to the differences in pinion diameters, drive member rack 80 and therefore drive member piece 68, due to the abutting engagement of pawls 77 with teeth 73 b, are forced to move in a distal direction, and drive member piece 68 motion advances piston 52 in the distal direction to force medication in reservoir 50 through injection needle 40 into the user. The injection is completed when the plunger 64 advancement is physically halted by abutting pen parts, immediately prior to which time the end of dose audible click has been made by pawl 152, at which time pen 20 is once again arranged in the ready or ready-to-be-cocked state shown in
Pen 20 can continue to be used to deliver its fixed dose until, for example, a locking feature prevents plunger withdrawal. At such time, pen 20 is to be disposed of and replaced with a similar but entirely new pen.
While this invention has been shown and described as having preferred designs, the present invention may be modified within the spirit and scope of this disclosure. This application is therefore intended to cover any variations, uses or adaptations of the invention using its general principles. For example, the force limiting feature provided by the multi-part plunger including the captured spring advantageously may be employed in other injection pens that include different and known mechanisms to provide a mechanical advantage between the plunger and the drive member. Still further, in an embodiment in which an injection spring is provided to cause drive member advancement in the injection process, the plunger could be provided with a trigger mechanism that, when the pen has been cocked and a small force is applied to the trigger mechanism, triggers the injection spring to further advance the plunger to operate the remainder of the pen to inject the medication. In such an embodiment, the trigger mechanism or plunger may include a display which disappears as the spring advances the plunger to notify a user when the injection has been completed by the injection spring. Further, this application is intended to cover such departures from the present disclosure as come within known or customary practice in the art to which this invention pertains.
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|Inovio As
|Electroporation device and injection apparatus
|2 Sep 2003
|11 Mar 2004
|Tecpharma Licensing Ag
|Overload safety device for a dosing mechanism of a product dispensing appliance
|3 Mar 2004
|16 Sep 2004
|Dca Design International Ltd.
|Drive mechanish for drug delivery devices
|3 Mar 2004
|16 Sep 2004
|Dca Design International Ltd.
|Improvements in and relating to drive mechanisms suitable for use in drug delivery devices
|Patente citante
|Fecha de presentación
|Fecha de publicación
|10 Oct 2011
|16 Oct 2012
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|11 Oct 2011
|30 Oct 2012
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|7 Dic 2009
|22 Oct 2013
|Tecpharma Licensing Ag
|Lock applied to setting and priming function after dispensing the last dose
|26 Feb 2010
|5 Nov 2013
|Tandem Diabetes Care, Inc.
|Methods and devices for determination of flow reservoir volume
|29 Jul 2010
|24 Jun 2014
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|19 Ene 2010
|19 Ago 2014
|Sanofi-Aventis Deutschland Gmbh
|Drive assembly and medication delivery device
|29 Jul 2010
|6 Ene 2015
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|29 Jul 2010
|15 Dic 2015
|Tandem Diabetes Care, Inc.
|Infusion pump system with disposable cartridge having pressure venting and pressure feedback
|4 Nov 2013
|2 Feb 2016
|Tandem Diabetes Care, Inc.
|Methods and devices for determination of flow reservoir volume
|6 Dic 2012
|24 May 2016
|Unitract Syringe Pty Ltd
|Accurate dose control mechanisms and drug delivery syringes
|1 Dic 2009
|15 Ago 2017
|Sanofi-Aventis Deutschland Gmbh
|Drive assembly suitable for use in a medication delivery device and medication delivery device
|7 Dic 2009
|12 Ago 2010
|Juerg Hirschel
|Lock applied to setting and priming function after dispensing the last dose
|19 Ene 2010
|12 Ene 2012
|Sanofi-Aventis Deutschland Gmbh
|Drive assembly and medication delivery device
|1 Dic 2009
|5 Abr 2012
|Sanofi-Aventis Deutschland Gmbh
|Drive assembly suitable for use in a medication delivery device and medication delivery device
|Clasificación de EE.UU.
|Clasificación internacional
|Clasificación cooperativa
|Clasificación europea
|21 Mar 2007
Owner name: ELI LILLY AND COMPANY, INDIANA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:IDEO PRODUCT DEVELOPMENT INC.;REEL/FRAME:019040/0156
Effective date: 20040602
Owner name: IDEO PRODUCT DEVELOPMENT INC., MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:JACOBS, ALEXANDER THOMAS;JUDSON, JARED ALDEN;REEL/FRAME:019040/0365
Effective date: 20040602
|28 May 2014
|Fee payment
Year of fee payment: 4


text:
Paco Rabanne BlackXS For Her
Paco Rabanee Black XS For Her, the hypnotic fragrance of a rebel princess.
The mysterious elixir is the scent of a rocker with a laidback charm. Seductive and intensely charming.
Black XS For Her is feminine and sensuous, evolving from fruity to floral to woody notes.
Emilie Coppermann and Marc Buxton built Paco Rabanne Black XS For Her around a heart of hellebore rose, with tamarind blossom, pink peppercorns and cranberry in the sharp, fresh top note, and a heavy dose of massoia wood, patchouli and vanilla in the base note.
£28.90 - £50.15
Only: £17.40 RRP: £20.50
Only: £34.00 RRP: £40.00

subset: commoncrawl


text:
In addition to the policies summarised on this page - you can download copies from the list below or get copies from the main office in the school
It is important for their progress that students attend school regularly and punctually. In the case of irregular attendance or unpunctuality, a written explanation , signed by parents , must be sent to the School Principal.
The school is obliged under law to report any student who is absent for twenty days or more, to the National Education and Welfare Board. Parents have a vital role to play in ensuring that students attend school regularly.
The school has a Board of Management. Membership consists of parents, teachers, community representatives and representatives of County Carlow Vocational Education Committee. The board is a sub committee of Carlow Vocational Education Committee.
The school operates a very successful book rental scheme in order to reduce the cost of books for parents. Books supplied in this manner remain the property of the school and must be returned when the students complete the courses in which the books are used.
Our policy is to approach discipline as positively as possible. Our school's code of conduct combines firmness with fairness and we aim to develop and encourage reliance on self – discipline and responsibility as students move through the school. A copy of the school code of conduct and rules is given to parents and is fully explained to students.
The school encourages healthy eating with a Breakfast Club in the morning and healthy lunches available to all students during the day. A well – stocked tuck shop is open during breaks offering a variety of snacks.
The school may be contacted at any time throughout the school year on an appointment basis during office hours. Formal parent – teacher meetings take place during the school term. School reports are posted home for every student during the school year. The Parents' Council meet regularly and work closely with the principal.
Information evenings are organised for parents on topics such as : New first year students, LCVP and Transition year courses etc.
Parents' courses are organized by the HSL officer on areas of interest to parents such as: Computers, Parenting skills, Anti–Bullying, Literacy and Numeracy, Study Skills etc.
An active parents' association is vital to the life of any school. The association fosters co –operation between school and home and promotes the educational welfare and interests of the students. The Parents' Association is a very valuable support to the school.
Each year, the school awards scholarships to students. These scholarships enable students to avail of extra tuition during the summer to improve their proficiency in French and Irish.
The school encourages students to participate in environmental groups and is actively involved in the "Green Schools " project.
Our students regularly participate in charitable work and fundraising , together with involvement in enterprise at the enterprise awards and enterprise trade fairs. Clubs such as the Homework Club, Music Club, Computer Club, Chess Club, Breakfast Club and Garden Club also take place within the school.
At Carlow Vocational School boys and girls wear a grey polo shirt. Boys wear grey or black trousers whilst the girls have a choice of either grey or black trousers or a fashionable tartan kilt. All pupils must wear the school jumper in black v-neck with a trim of red and white. The school crest is proudly worn on the jumper. There is a
matching school jacket with crest which is optional. All
pupils are required to wear black shoes. P.E. gear is based
on students' individual choice of tracksuit bottom with a
grey school tracksuit top and white polo shirt, both carrying the school crest.


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text:
What's your favorite skateboarding video?
Bucky Lasek, Birdhouse
I think I like Animal Chin best because of the different perspective it had on skating. It was like a movie; I mean, it was cornball, but that's why I like it. Wait, I like Second Hand Smoketoo. Was that it? Was that the really good Plan B video? I can't remember … I think that was it that one. That one had good skating in it.
Danny Way, Alien Workshop
I like Future Primitive. I like the old Powell videos best out of all skate videos. They had good humor and were shot well. Some of that shit … like Lance Mountain doing all his stuff¿Lance ruled. It was mainly Lance that made them funny. Now, people try to make funny videos but they can't¿Powell was ahead of its time.
Bob Burnquist, Anti-Hero
Virtual Realitywas the best¿when Colin and Danny came up with all that vert stuff. I was in Brazil when I saw it, and it blew me away. We'd just finished our Anti-Hero video, and it made me appreciate all the work that goes into it. I did probably 60 percent of the editing. That's a lot of work that goes into videos.


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Firstcall Research has recommended hold rating on Zensar Technologies with a target of Rs 302, in its December 12, 2012 research report.
Firstcall Research has recommended hold rating on Zensar Technologies with a target of Rs 302, in its December 12, 2012 research report.
"Zensar Technologies (Zensar) is a globally renowned software services company that specializes in providing a complete range of Software Services and Solutions. Zensar is ranked amongst India's Top 20 Software Services Companies by National Association of Software and Services Companies (NASSCOM) and is also recognized by the Department of Scientific and Industrial Research (DSIR) for its robust in-house Research and Development practices and an acknowledged leader in Innovation. Zensar is the world's first enterprise-wide SEI CMM Level 5 Company and enjoys a strong presence in the United States, Europe, Africa, Middle East and Asia-Pacific regions. To service Global Customers, Zensar has Delivery Centers in Pune and Hyderabad in India, China, Japan & the UK. With 6000+ associates, 400+ customers and 14 nationalities operating in more than 20 global locations, Zensar helps transform Global Corporations."
"The company's net profit decreased to Rs.321.70 million against Rs.400.50 million in the corresponding quarter ending of previous year, a decrease of 19.68%. Revenue for the quarter rose 27.46% to Rs.5450.50 million from Rs.4276.30 million, when compared with the prior year period. Reported earnings per share of the company stood at Rs.7.39 a share during the quarter. Profit before interest, depreciation and tax is Rs.605.60 millions as against Rs.714.40 millions in the corresponding period of the previous year."
"At the current market price of Rs 265, the stock P/E ratio is at 6.18 x FY13E and 5.28 x FY14E respectively. Earning per share (EPS) of the company for the earnings for FY13E and FY14E is seen at Rs.42.88 and Rs.50.22 respectively. Net Sales and PAT of the company are expected to grow at a CAGR of 32% and 18% over 2011 to 2014E respectively. On the basis of EV/EBITDA, the stock trades at 3.34 x for FY13E and 2.66 x for FY14E. Price to Book Value of the stock is expected to be at 1.51 x and 1.18 x respectively for FY13E and FY14E. We recommend 'HOLD' in this particular scrip with a target price of Rs 302 for medium to long term investment," says Firstcall Research report.
FIIs holding more than 30% in Indian cos
Disclaimer: The views and investment tips expressed by investment experts/broking houses/rating agencies on moneycontrol.com are their own, and not that of the website or its management. Moneycontrol.com advises users to check with certified experts before taking any investment decisions.
To read the full report click on the attachment


text:
Ohio State University researchers believe that new pink dye-sensitised solar cells (DSSCs), which get their pink colour from a mixture of red dye and white metal oxide powder, could be used to produce next-generation low-cost solar panels.
The researchers report that, currently, the best of these new pink materials convert light to electricity with only half the efficiency of commercially-available silicon-based solar cells – but they do so at only one quarter of the cost.
Yiying Wu, assistant professor of chemistry at Ohio State, said: "We believe that one day, DSSC efficiency can reach levels comparable to any solar cell.
"The major advantage of DSSCs is that the cost is low. That is why DSSCs are so interesting to us, and so important."
He explained that pink is a typical colour for DSSCs. Most use dyes containing ruthenium, which has a red colour; the metal oxide powder that turns the mix pink is most often titanium oxide or zinc oxide, which are both whitish in colour.
But Wu's materials are novel in that he's using more complex metals and exploring different particle shapes to boost the amount of electricity produced.
The project marks the first time that researchers have made a DSSC from anything other than a simple oxide. Wu and his colleagues chose zinc stannate because it belongs to a class of more complex oxides with tunable properties.
"We asked ourselves, what structure is best for gathering light and also transporting materials –
a tree! The leaves provide a high surface area for capturing light, and the branches transport the nutrients to the roots," Wu said.
"In our DSSC design, the dye-coated particles would provide the surface a rea, and the nano-trees would branch out in between them, to transport the electrons."
US boffins go pink for green energy
By Robert Jaques on Aug 1, 2007 11:15AM


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On January the 13th new licence laws are being applied. I'm 16 and am going to do my full licence next year. At the moment I have a moped on a provisional licence. Will the new rules apply to me or will i stay under the old rules?
New Motorcycle Licence Laws
Posts 7 | Views 455
Hi Cal
sorry dude but you'll have to comply with the new regulations i'm afraid.
Unless you're 17 before 13th of Jan and pass your test, in which case your bike entitlements would as if you passed your test today, and would not be changed by the new rules.
Ride safe.
People sleep peaceably in their beds at night only because rough men stand ready to do violence on their behalf.
**Thanks **
Okay thanks mate. At least i won't get my hopes up. Just means I have to wait until I'm 21 until i can have any bike i want. Cheers for taking the time
new laws
as far as i can make sense of the new laws. it would be a waste of money to take your test at all until you are at least 19 because you will be restricted to a 125 for 2 years so you may as well stay on the 'L' plate cos you'd have to take another test to move up to the next 47bhp level when you are 19. the point is at 17 you would be taking a test to ride the bike you are already riding
taking a test to ride the bike you are already riding
with cheaper insurance, with a pillion, on a motorway - passing does have it's advantages
Bubble Burst
Sorry to burst your bubble on this but even when your 21, with the new laws you will not be able to ride ''any bike you want''.
At 19+ you must take the test on a 400cc and you can ride a bike up to 46.6 Bhp. You can restrict any
motorcycle to this power so long as the original manufacturer's declared
output was less than 92 Bhp. Large bikes such as Honda CBR1000, Suzuki
GSX1000, Triumph Sprint etc. are not allowed.
Now wait a minimum of 2 years to qualify for the next test,
or reach the right age bracket (24). Then when you reach 24 you will have to take a test on a 600cc to get full license.
If i take my A1 test when I'm 17 and A2 test when I'm 19. I can take my A test when I'm 21. The think the made me wonder if i could still abide by the current rules is my provisional licence say i can ride category 'A' when I'm 17. Category 'A1' and 'A2' where left blank.


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Kendall Jenner, 16, showed off her beach bod as she hit the shores of Malibu on Saturday. The model rocked a turquoise bikini and shades as she tossed around the football with a friend and her nephew, sister Kourtney Kardashian's 2-year-old son Mason. Dressed in Hawaiian-print trunks, the little guy looked happy to spend some special time with his aunt! (His mom must have been at home with his new little sis, Penelope Scotland, who was born July 8.)
Later, Jenner tweeted a video of herself and a friend listening to Kanye West's song "Mercy" as they cruised back from the beach because no Kardashian family member's day is complete unless she's also promoted another family member (or boyfriend of)! Think Kim's man ever gives Kendall and co. a private performance?
Besides all her Kanye-inspired jamming, Jenner's also been busy with a new project — a book! She and sister Kylie, 14, revealed to E! last month that they're working on a young adult-novel targeting fans of Twilight, The Hunger Games, and Harry Potter. "We want to do something so different, something that we really love," Kendall told E!, adding that English is her favorite subject. The girls are working with a co-writer, author Maya Sloane, on a science-fiction story set 200 years in the future. If all goes as planned, the Jenner gals' tome will be available in time for us to pack it in our beach bag by next summer.
Would you buy a book written by the sisters?


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Welcome to Sturgis South Dakota!
70th Sturgis Rally and Races This Year!
Though we are just starting out in 2010, the 70th annual occurrence of The famous Sturgis Rally and Races are right around the corner. Are you coming?
Though the 2009 Sturgis Motorcycle Rally is just fading into our memory, it is time to start getting for the 70th Anniversary of this world famous event!
Thousands of bikers, motorcycle enthusiasts and people watchers from across the globe have made their plans to make the trek by motorcycle (the sacred way), truck (with bike trailer), car, boat, plane and train to be a part of the seventieth anniversary of the Black Hills biggest event.. The Sturgis Motorcycle Museum & Hall of Fame is gearing up for a large crowd that have come another year and those who are making their pilgrimage for the first time.
The world famous museum has been building their world-class historic motorcycle exhibits and accepting nominees for the Hall of Fame. The Motorcycle Museum will have a big collection of official 2010 Sturgis Rally patches, pins and other memorabilia to make your trips memory better.
The Sturgis Motorcycle Museum officially opened in 2001, the museum was started as a way to preserve motorcycling history and culture,combining our rich past history with the current event. Throughout the rest of the year, you can support the museum and further this cause. You can sign up to reap the benefits of membership. Members receive exclusive motorcycle patches, free admission to the museum, Sturgis gift shop discounts, invitations to member's only events, and more.
While being present at the 70th Sturgis Motorcycle Rally will make you a part of motorcycle history, support of the non-profit Sturgis Motorcycle Museum will help to ensure that heritage is preserved.
999 Main Street
Sturgis, SD 57785
(605) 347-2001
TruTV Features The Full Throttle Saloon
TruTV has had an eye full of Sturgis Rally fun and decided to make a show featuring Micheal Ballards Full Throttle Saloon. This will be a One-Hour Series Premiering Tuesday, Nov. 10, at 10 p.m. (ET) TruTV Goes Behind the Scenes at Michael Ballard's Biker bar The Full Throttle Saloon claiming the title of the worlds largest biker bar. http://www.trutv.com/index.html
The shows will detail the events and also the struggles of running this operation. It will detail the behind the scenes of running a operation that is 30 acres of tattoos, leather, alcohol, Harley Davidsons and the ladies and gentlemen that ride them. The Full Throttles set up includes indoor and outdoor bar, a famous burn out pit, numerous stages with live music, tattoo parlor, wresting ring, stores, vendors, cabins for rent, and parking for thousands of bikes.
What an operation! This is all planned for the two weeks of Sturgis Motorcycle Rally.
I wish Micheal the best as he has always been a friend and helpful to us. Micheal has donated a booth to our non profit organization and helped us with fundraisers for the Rapid City Club for Boys for many years. It will be interesting to see the behind the scenes of the Full Throttle Saloon!
Thanks to Mike, Angie and the Full Throttle crew for all of your support ! FTS rocks!
My Latest Video Production from Sturgis Rally 2009. The Famous Main Street Photo and the Hail Storm!…
Sturgis Motorcycle Rally 2009
If you want more information after viewing this page please click on the rally tab or click on this link http://mrkenslifeinsturgis.com/rally/ for information and videos of Sturgis Rally 2009
Video taken in the City Park of Sturgis South Dakota USA
Please take a break from your internet toils and enjoy! A short video to welcome you to my site…
Please see the footage below of the bronze work of Samuel Sturgis here at the city park, while shooting this I had a scaled surprise visitor! Samuel Sturgis is the historical figure that this fine town is named after. You can find out some more by clicking the history tab above or click here A Little Sturgis History


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FALL SPORTS PREVIEW: Defensive mentality to carry Fairfield on courtDiers trying to mold a green roster for 2014
The Fairfield volleyball team will not look the same this season as it has in recent years.
Volleyball fans have gotten used to height around the net and long-term starters putting up impressive numbers. The team graduated 10 players, four of which filled huge roles for the Trojans. Sydney Burnett, Fairfield's all-time leader in assists with 1,310 of them, is gone. Marisa Repp, who led the team in kills in 2013 with 240 and is ninth on the school's all-time kill list, is gone. Back row player Cheyanne Laux, who is third in school history in digs, is gone. Hannah Greiner, whose intimidating presence was felt at the net last year with her 180 kills and 50 blocks, is gone.
Now, those who watched the stars of yesterday must form together to write their own history. This team isn't blessed with a great amount of height and experience; therefore, according to 29-year coach Nancy Diers, it'll have to win with defense and grit.
Senior Alexis Ring will likely start at setter. Ring has been battling back injuries since her sophomore year, so preventative medicine like icing and stretching is important for her to stay healthy.
"Ring does an incredible job of communicating with the team," Diers said. "She's a very intelligent volleyball player."
Ring will be backed up by Kelsey Roberts, who went from the third string setter all the way up to a starter last season because of injuries and her high level of play. She finished first on the team last year with 365 assists, so the Trojans will have no problem going two-deep at this position.
Junior Molly Ryan will inherit the middle hitter spot. One of the few Trojans with a height advantage, Ryan smacked down 58 kills last year in limited playing time.
"Molly consistently got better each match last season," Diers said. "She'll have more responsibilities this year and she'll need to be more aggressive at the net."
Madison Roberts will take over at outside hitter. Much like Ring, she has battled injuries. She'll attempt to keep her knee comfortable this season so she can stay in the lineup. In the back row, junior Mackenzie Flattery will start as a defensive specialist.
"She'll need to continue to read the ball and pick out where the opponent is trying to hurt us," Diers said. "Her and the other starters will have to step up to begin with so the other kids can work to fill in and find their niche."
The rest of the starting lineup will play itself out over the next couple weeks. Senior Jolea Burkhart will see time as a back row defender who can bring speed and smarts to the court. Mackenzi Harwood will play more of a utility spot because she is competent in different spots. Delaney Neil will be in the rotation as a middle hitter.
"[Neil's] a nice player who just needs to see time on the varsity court," Diers said. "Tempo will be her struggle in the beginning, but she'll get used to the tempo of our offense and get involved in the game."
Underclassman Natalie Angstead, Brooke McClain, Kaylee Watson and Shelby Heston will also see playing time on a team that in Diers's words, "needs to realize that they're the main event now."
"These girls were so supportive of the players that came before them," Diers said. "But they need to realize that [younger] players are looking to them now. We've made huge strides but they need to have confidence in themselves."
The gym is quieter than it has been in recent years because the team is still searching for its boisterous leader. The strength of the team will have to be its aggressiveness, its confidence, and its willingness not to let the ball hit the ground. Serving, smart play and determination will be essential for the Trojans to have success in a conference that is getting consistently better from top to bottom.
"For the first three or fours weeks, defense will have to be our strength until we have the confidence to attack offensively," Diers said. "It's not because we're not capable of hitting, we're just not seasoned yet."
Fairfield will start Thursday with the Steve Heisel Quad at home against Albia, IMS and Eddyville-Blakesburg.
2014 Fairfield Volleyball Varsity Schedule
8/28 Steve Hisel Quad
9/4 @ Mt Pleasant
9/11 vs. Washington
9/13 @ Burlington Notre Dame Invite
9/20 @ Ottumwa Invite
9/23 @ Keokuk
9/27 .@ Burlington Invite
9/30 vs. Fort Madison
10/7 vs. Mt Pleasant
10/11 @ Oskaloosa Tournament
10/14 @ Washington
10/18 Fairfield Tournament
10/21 vs. Keokuk
10/23 @ Fort Madison
10/27 Class 4A Regionals
Southeast Conference 2013 Standings
Team, Conference Record, Overall Record
Mt. Pleasant 8-0 29-5
Fairfield 5-3 20-15
Fort Madison 5-3 19-22
Keokuk 1-7 4-21
Washington 1-7 5-25
Head Coach: Nancy Diers, 29th year
Key Returnees: MH Molly Ryan (Jr.), OH Madison Roberts (Sr.), S Alexis Ring (Sr.), S Kelsey Roberts (Jr.), MB Mackenzie Flattery


text:
Since we were just talking about Japan's current excitement about Dickies, we show you another new collaboration. Beams once again gets together with the US brand and this time worked on a series of madras shorts. Overall they present three shorts in the series and they are available now here.
Beams x Dickies Madras Shorts
Highsnobiety Style


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Sun 3rd Nov at 10:30am - 3:00pm
The Toy Train And Collectors Fair
@ Westpoint Exhibition Arena, Exeter
This event has been and gone!
Catch the next one:
Check out the info below for future tour dates, and track them to receive alerts when they tour near you
The Toy Train And Collectors Fair
Catering for all collectors, walk, browse and look for those elusive and hard to find models.
Dinky, Corgi, Minichamps, Hornby Bassett Lowke, Meccano, Spot-On, Marklin, Scalextric, EFE, Actionman, Dolls,Teddies and much more all under one roof!
See www.bulldogfairs.com or call 01373 452857 for further information.
Track this event
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Venue Facts
Venue: Westpoint Exhibition Arena
Website: westpointarena.com
Enquiries: 01392 446000
Bookings: 01271 323355
Disabled Bookings: 01271 323355


text:
It's time for Friday Night Bites, and we're going meatless for lent!
Elizabeth's Easy Homemade Margherita Pizza
Growing up, Friday night was always Pizza Night. My mom, Karen, always treated us to her special homemade pizza, so no matter what was going on, we always made sure to be home for Friday night dinner. She would always go one step further and personalize a portion of the pizza for everyone: pepperoni and anchovies for my Dad; pepperoni, onions and peppers for her and me, pepperoni for my brother, sometimes we'd do sausage, onion and peppers. When I started dating my husband, Arnie, he would come to the house purposely on Friday just to have her pizza (I think he was coming to see me too!) When I set up house, I carried on the tradition and Friday night is always Pizza Night at the Mascali's – whoever happens to be at the house, joins in – open door policy.
Although we've been known to go crazy with the toppings, we're enjoying a purist phase with Margherita Pizza. Here's the basic and simple recipe, have fun and create your own favorite combinations. You can also create a traditional pizza by swapping the fresh mozzarella for grated mozzarella (use a part-skim variety, it has less moisture).
Homemade Margherita Pizza – (Yields 2 large pizzas)
- 2 balls of pizza dough – they are typically about 1 lb. each (I buy dough at our local pizzeria, you can buy it or make it yourself)
- ¾ cup tomato sauce
- 1 lb. thinly sliced mozzarella (we have been using fresh mozzarella and it's out of this world)
- Basil (optional)
Remove pizza dough from the refrigerator and allow it to warm to room temperature, at least one hour. Preheat oven to 450°. Grease 2 large pizza pans. Place a ball of pizza dough on each pan and starting in the center of each gently knead the dough pressing it out toward edge of pan. Ladle ¼ cup of sauce in center of each and again spread toward outer edge until evenly distributed (if sauce is looking a little thin for your taste, ladle a bit more on). Top with thinly sliced mozzarella. Bake for 12 minutes or until bottom is golden brown and top is bubbly. Remove from oven, top with basil (optional), slice with pizza wheel and serve. Pop 2nd pizza in oven – the first will go fast!
Enjoy and cheers to the weekend!
A NEW series by the Partybluprints Blog


text:
About the Book
The Zuni have traditionally used small stone carvings of animal figures as power objects and mediators between themselves and the spirit world. Any object that has special meaning can be used as a fetish. In this fascinating, informative, and beautifully illustrated guide to the fetishes of the Zuni people of New Mexico, Hal Zina Bennett explores key principles of Native American spirituality and how early Zuni teachings can benefit us all today. He provides an excellent guide to Zuni traditions and an intriguing picture of their early life, along with detailed instructions for using fetishes for mediation, reflection, and insight in modern life. He describes key fetish figures, including the Guardian of the Six Regions, their legendary meanings, and the personal qualities each figure can support and help its owner develop.
In explaining the nature of fetishes and the psychological and spiritual benefits that we can gain from their use, Bennett provides illuminating cross-cultural comparisons, stimulating exercises, and journaling opportunities.
Educator and Librarian Resources
Product Details
- Imprint: HarperOne
- On Sale: 04/09/1993
- Trimsize: 7.375 in (w) x 9.25 in (h) x 0.384 in (d)
- Pages: 192
- List Price: 19.99 USD
- BISAC1: BODY, MIND & SPIRIT / New Thought


text:
Tanya Remer Altmann
About the Author
Tanya Rember Altman MD, FAAP is a board-certified pediatrician in private practice, clinical instructor at UCLA, and a columnist for Los Angeles Family magazine. As an active Fellow of the American Academy of Pediatrics (AAP), she is on the executive board of the section on media and co-chairperson of the media resource team. Dr. Altman has regularly appeared as a medical expert on numerous television programs including Santa Barbara's morning news and Lifetime's "What Should You Do?" She is currently a regular guest on the PBS parenting show "A Place of Our Own" and on the Food Network program, "Take It Off!"


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Since I don't have any new paintings to show, and likely won't for another month or so, I thought I'd show you a quick one I did a while ago just for drawing practice. Of course, it's not perfect, but that's the beauty of doing something just for practice. I don't have to try to make it perfect. I take it as far as my mood allows, then it gets thrown into a box.
10" x 8"
Soft Pastel on Suede Matboard
I hope the remainder of your summer is excellent, and I will see you in the fall.


text:
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Check out the info below for future tour dates, and track them to receive alerts when they tour near you
Never miss another 'Brendon Burns' show
See all dates for Dave's Leicester Comedy Festival
Dave's Leicester Comedy Festival - Home Stretch Baby: Brendon Burns
Dave's Leicester Comedy Festival is Britain's longest-running comedy festival.
The festival was set up in 1994 and has been exploding onto the streets and spaces of Leicester each February since.
See www.comedy-festival.co.uk for further information.
Brendon Burns
Noisy, manic and in-your-face comedian from Australia. This foul-mouthed antipodean is known as a masterly exponent of his art, intelligent and hilarious, railing against bigotry without preaching and taking the audience to the edge of their belief systems with his full on comedy routine. Brendon has appeared on The 11 O'clock Show and The Stand Up Show.
'The most jaw-droppingly awkward, painful, yet ultimately rewarding piece of stand-up we've ever seen' (Time Out)
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Venue Facts
Venue: Just The Tonic Leicester
Website: justthetonic.com/leicester-comedy
→ Leicester 8 min walk


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Earlier in the year PressureWasher.co.uk joined the Trust Pilot customer review service. This allows people who have made a purchase through the website, or on the phone, to write about what they thought of the service. The reviews are completely impartial, and because the entire process is orchestrated by Trust Pilot, a respected third party customer review service, there is no way that PressureWasher.co.uk can delete or have any kind of influence on the customers' reviews. The good news is that after 25 reviews we have received an average rating of 9 out of 10, meaning that according to Trust Pilot's ratings system our service is… Excellent!
Here are just a few of the comments our customers have written:
"Cracking service – would definitely recommend."
"My purchase was quick and easy. The website was easy to use and the item was delivered very quickly great service all round."
"…best price I could find on the web…"
"At last a company who know how to deliver goods at a good price with superb customer service."
These comments mean something because they come from people with firsthand experience of PressureWasher.co.uk's customer service, delivery procedure and products. Because we work hard at keeping our customers informed about their purchases and delivery information, we have been able to receive such positive feedback. Of course, that doesn't mean we can afford to relax when it comes to looking after our customers – one negative review could bring our Excellent rating down. And so we intend to work harder than ever from this point at delivering quality service and the very best in pressure washers and other cleaning equipment.
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Your donations keep RPGWatch running!
Interplay - Now Hiring
by Dhruin, 2007-11-27 22:33:20
Tired of working for a stable company that pays regularly? Looking for something exciting and edgy with a company we last saw getting turfed out because they couldn't pay their rent? Then check out Interplay's three openings advertised on Gamasutra - Jason Anderson is listed as the contact to hire an environmental concept artist, system designer and content designer for their next-gen MMO.
Source: No Mutants Allowed
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Shreveport: 188 miles east of Dallas
Hankering for some Louisiana food? You don't have to head for N'awlins or Lafayette. Louisiana's tourism office promotes Culinary Trails in eight sections of the state, pointing visitors to some of the most "Louisiana-y" of the cafes in each section. They're not all fancy and expensive. Frankly, some are holes in the wall. But good? You bet. Here are a few in the Shreveport area to get you started.
Herby-K's has an enormous classic diner menu for lunch and dinner, but the signature dish is the Shrimp Buster: four big, butterflied fried shrimp piled atop French bread with special sauce on the side.
Kim's Seafood is known for boiled crawfish in season and crawfish egg rolls year-round, plus gobs more seafood specialties.
Top it all off with a slice of the famous icebox pie at Strawn's Eat Shop. Choose from strawberry, chocolate, coconut, butterscotch, banana and, in season, peach. Yum.
Mary G. Ramos
Contact: For exact days and hours, check each restaurant's website.
Louisiana tourism site: louisianatravel.com/culinary
Herby-K's, 1833 Pierre Ave., Shreveport; 318-424-4724; herbyks.net
Kim's Seafood, 901 Benton Road, Bossier City; 318-752-2425; search Kim's Seafood on Facebook.
Strawn's Eat Shop, 125 Kings Highway, Shreveport, 318-868-0634 (see website for other locations); strawnseatshop.com


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I don't know if I'm missing the boat, but this keeps giving me an error, and I'm not even to the 'hard' part of my homework. Actually, I don't get an error when I compile and run the program, but it generates an error in my computer and pulls up the windows error window.
The whole part of the homework is to create a linked list, print it, and then add a value to it, and print again. I can't seem to get the linked list part correct...what exactly am I doing wrong?
Code:#include <stdio.h> #define AMOUNT 5 struct linkedlist { int value; }; struct linkedlist value[5]; int main() { int i; printf("Enter five numbers\n"); for(i = 0; i < AMOUNT; i++) scanf("%d", value[i]); printf("you have entered the following numbers:"); for(i = 0; i < AMOUNT; i++) printf("%d\n", value[i]); }


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Unions threaten more action as 1.5m striking workers warn: 'We're in for the long haul'
Union leaders are to meet in a fortnight to consider further industrial action over pensions after yesterday's strike hit 21,000 schools and led to thousands of cancelled hospital operations.
Libraries, museums, residential homes, ports, courts and Jobcentres were disrupted as about 1.5 million public sector workers joined picket lines and marches in the biggest strike for a generation.
More than 1,000 rallies were held across Britain including one in London attended by tens of thousands of workers. School crossing attendants, refuse collectors, weather forecasters and librarians joined teachers, nurses, immigration staff and civil servants in protest against pension reforms.
Up to 6,000 non-urgent operations were cancelled and tens of thousands of out-patient appointments, including some for chemotherapy, were postponed. In some areas up to 40…


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Separate names with a comma.
Discussion in 'Off-Topic' started by tec71, Nov 13, 2010.
I'm thinking of buying a pair. Any suggestions?
Bose or Dr. Dre
I'd go Bose...I heard the Dr Dre ones aren't built very well...my friend worked at apple and said that he saw a bunch get returned...the cables kept coming out of the headphones
I've got a pair of Shure SE530 that I would wear to my grave if I could. AWESOME!!
What is your price range? Those mentioned so far are pretty expensive. I have a couple pairs of Sony NC ones and they work pretty well for the money.
I'll most likely buy at the upper price range if I think the value is there. I can buy the Bose QC-15, but I'm just not that convinced that they are that much better than say the Sony's, or more importantly even if they are that much better if I'll notice or if I need that much better sound. I'm not a music junkie, and want them primarily for travel. I don't travel that much but when I do I go hard and a lot of very noisy little planes. I will use them mostly with my iPod touch.
I was prepared to spend a lot a couple of years ago (Bose I was thinking at first). But based on advice from a friend and my (web) research I got these instead:
Sennheiser HD 280 Pro - headphones - Ear-cup, Binaural - Black
A broader Google search ("Sennheiser headphones"):
headphones - Google Search
I've been very happy with the sound (and the big savings) as well as the engineering. They fold up very nicely. You can spend a lot more for other Sennheiser models but there was really no need for me to.
Go to headfi.com. That place is the best for info. on headphones. Be careful though, Bose is a dirty word over there. Bose charges way to much money for the amount of quality they have. They are not respected among audiophiles. Bose is seen more as a marketing company more than anything else. Anyway, lots of better alternatives than Bose products.
Another vote Sennheiser, From direct experience. You can get ones that outperform the Bose at 1/2 or less the cost, and for the same $ blow the Bose out of the water.
If you really want the best sound cancelling, these are best, Westone's. They are a mix between an earplug and a headphone. They aren't "active," but again from direct experience they work much better in reducing ambient noise.
Best Earphones for Motorcycle Riders
I got the Westone 1 model.
I absolutely LOVE my Bose QC-15 headphones. Not only are they super comfortable but the noise cancellation is very impressive and the sound quality is superb. On airplanes, they make all the difference in the world. If you are willing to shell out some cash for a good pair, these are well worth it.
This topic comes up every once in a while so sorry for resurrecting this thread but I'm looking for some decent < $100 over the ear type headphones (preferably noise cancelling). Head-fi.com has almost too much information. Any audiophiles have any recommendations in that price range? I'd mostly use them at work.
Not noise canceling but I've been very happy with the Audi-Technica ATH M50's. I just wish I had gotten a coiled wire. I team this up with a little headphone amplifier. The one real nice feature is that you can crank them without the sound leaking. The bad part is after 3-4 hours your ears will get a little hot.
Able Planet is a very good value buy. There are certainly higher quality options, but they are as good as Bose, for significantly less
Bose will be good if you only want the noise canceling for flights. If you want music, Bose and Dre both suck.
For half the price you can get something better than Bose: http://www.amazon.com/Audio-Technica-ATH-ANC7B-Noise-Cancelling-Headphones/dp/B00FYWCL2E/ref=sr_1_2?ie=UTF8&qid=1406340986&sr=8-2&keywords=ATH-ANC7b
If you just want cans for work, I would get this: http://www.crutchfield.com/p_143MMNTMB/Sennheiser-Momentum-On-Ear-Black.html?tp=60828
I have the over ear ones, and love them. 9+hrs a day and they are still comfy.
Any good earbuds that are bluetooth that aren't necessary notice canceling - but seal to a point they kill most of the noise?
Don't care but it was a shock to see a Herbicide post.
Probably because they are detachable.
I have these: http://www.amazon.com/Shure-SRH440-Professional-Studio-Headphones/dp/B002DP1FTU. Not noise cancelling, but they work well.
I fly a ton--one or two times a week. These are lifesavers and awesome, but expensive:
Still some of the better $300 that I've ever spent.
I have the Sennheiser Hd 280 mentioned earlier in the thread. A little bulky, but if that isn't a concern they sound great and you can usually find a good deal on them.


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More than 60 children face starting at a new school when theirs closes for good this week.
Lessons will end at the Discovery New School, in Broadfield, on Friday (April 4) after it was ordered to close by the government, having failed to meet the standards required.
The school was opened in September 2011 and ordered to close in December 2013 after being judged 'inadequate' following its first Ofsted inspection.
Regarding the future of the children, West Sussex County Council confirmed their were 66 youngsters on the role when the decision to close the school was made.
Of those, 54 have found places at West Sussex schools, one child has applied to a school in East Sussex, two have moved to Somerset, one will be home educated and one has moved to a prep school.
One parent has yet to confirm their place and four families, including six children, have not contacted the council.
A council spokesman said: "We will follow up with these families after the school has closed.
"However, there are sufficient local places for the remaining children whose families are yet to contact us."


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To Link to This Page CLICK HERE!
Four Tips To How You Can Make That Cat Eco-Friendly
There are many people who would prefer to have a cat eco-friendly as opposed to a dog. Yet, having a feline friend is quite a big responsibility. There's the food you must feed it, the kitty litter, the flea control, all of which directly affects the environment. Being eco-friendly enough would mean that people have to take full responsibility for their pets and ensure that they will be living a greener life. There are various ways to go green with cats.
Four Tips To Make Your Feline Friend An Eco-Friendly Feline Friend
Eco-Friendly Cat # Tip 1 - Spay Or Neuter Your Cat
How many times have you heard you need to have your cat spayed or neutered? This is a task any responsible pet owner needs to do. There are so many feral stray cats eco-friendly that tend to attack people and other pets. Stray and feral cats can give quite a problem. Female cats can make up to three times a year, birthing at least three kittens per time. When you neuter your male cat, you're actually improving his health. He will be more resistant to prostrate diseases, infections and testicular cancer.
Not only do you improve your cat's health, you are also protecting the local wildlife and helping to lessen the burden on your local animal shelters. You can visit your nearest veterinarian to have your cat neutered or spayed.
Eco-Friendly Cat # Tip 2 - Choose Healthier Cat Food
During 2007, there were several pet food recalls because an ingredient called melamine was causing the deaths of many cats. This kind of disaster in the future will be easily avoided. Instead of worrying about what your eco-friendly cat food contains all the time, you can consider eco-friendly cat food for your favorite feline by making your own. Cats need a diet of meat, bones and organs. Add taurine to the diet so that the food is healthier. However, if you don't have time for this... make sure you read the labels on the cat food you intend to buy.
Eco-Friendly Cat # Tip 3 - Green The Waste
Cat litter is one of the biggest problems in a lot of cities. It is one of the biggest contributors to pollution in the environment. When feces are flush down the toilet, it pollutes the waterways. Cat feces contain pathogens that are dangerous enough to cause diseases. Composting cat eco-friendly litter is also not good idea, as this might do more harm than good since it will pollute its surroundings.
Five Ways To Dispose Of Cat Litter Safely
- Find a good and safe place to bury your cat's feces. It has to be far from the gas and water pipes; a place where it can do no damage of spreading contamination.
- When you find a good place, dig a hole there no lesser than one foot deep.
- Bury your cat's feces.
- Add some decomposable waste and mix it thoroughly. Make sure you have crushed the feces into very small unrecognizable pieces.
- Lastly, cover it with soil. Make sure you have covered it well and prevented it from being smelled by other animals.
Eco-Friendly Cat # Tip 4 - Use Natural Flea Control
Fleas can be found in dirty animals. To avoid this, just bathe your cats eco-friendly with natural shampoo made out of natural flea repelling herbs. Then powder them with natural powder made from citronella, eucalyptus and other aromatic herbs. Good grooming will help your cat eco-friendly be healthier and happier.


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Flood service notice
Ronald A. Flood, 63, of Belfast, passed away April 28 at Harbor Hill in Belfast. A celebration of Ron's life will be held at 1 p.m. Saturday, May 17 at Chris and Mary Floods' home. Arrangements are under the care of Riposta Funeral Home in Belfast, Maine.


text:
Nature Multi Animal Print
Please Note: This item cannot be delivered to a PO Box, only to a street address
This range is a machine heat set which is heavy duty, anti - static and it is easy to clean. Inspired by the jungle we give animal prints a modern edge!
* Easy to clean
* 100% Heatset
* Low allergen
* Light weight
* Strength and durability
* Made in Turkey
Please note: Allow for a slight variation of colours depending on monitor settings
IMPORTANT TIP: We recommend that an anti-slip pad is used underneath rugs to prevent slippage between the rug and the surface it is placed on


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Vanessa Williams was born in Tarrytown, New York on March 18, 1963. Her parents are of African-American descent, and Williams grew up in a predominantly white middle-class suburban area in Millwood. Williams is a multi-talented contemporary African-American performer specializing in song, acting, and modeling.
On Sept. 17, 1983, Williams was the first African American to be crowned Miss America. She began her career as an entertainer and has been successful since. She has been nominated for a number of Grammy, Emmy, and Tony Awards. Williams is also a part of a new ABC show that starts soon. Click here to view.


text:
The charismatic former president of Mexico offers a candid and provocative perspective on the state of world affairs.
As president of Mexico, Vicente Fox brought true democracy to the country after seven decades of one party rule. Elected as a political outsider with a message of honesty, change, and hope, he is truly a hero of democracy, and this vivid book interweaves his inspiring personal story with his hopeful new vision for the future of the Americas.
President… (more)
Publisher: Plume (October 04, 2007)
Format: EPUB
Page count: 400 pages
File size: 887 KB
Protection: DRM
Language: English


text:
Where Are We Now with Human Capital Theory in Australia?
The dominant economic paradigm for the study of wage determination is the human capital model. Increasingly, however, there is growing discontent with this model. The catalyst is the empirical literature on important earnings relationships which cannot be explained by competitive wage theory. Is human capital theory redundant? How useful is the model in the 1990s? This paper provides an assessment of the current status of human capital theory in Australia. The analysis demonstrates that even in a non-competitive environment such as Australia the human capital framework is extremely useful for the study of wage determination. Its weakness is its inability to explain significant and persistent inter-industry, inter-occupational and gender wage differences. Copyright 1997 by The Economic Society of Australia.
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Volume (Year): 73 (1997)
Issue (Month): 220 (March)
Pages: 51-78
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text:
It was all a hoax.
The alleged abduction of a 14-year-old Batavia Middle School student by an unknown man in a black van – was made up.
Police said the entire incident was fabricated by the girl in order to alter the facts about where she really was.
Read our complete coverage:
In LeRoy, residents of the school system are left to wonder why their school superintendent suddenly quit.
Cindy Herzog, who has been the superintendent of LeRoy Central for the past three years, resigned late on Friday, effective immediately.
The Board of Ed in LeRoy has named Dr. David DeLoria interim superintendent – a position he held just before Herzog was hired.
It is school Election Day. Voters are heading to ballot boxes in all Genesee County School Districts today deciding the fate of school budgets for the coming year. There are also elections to boards of education.
See a list of all Budget votes and Board Elections:
Accused murderer Scott Doll will take the stand in his own defense this morning.
The defense began its case yesterday. Doll is charged in the February, 2009 beating death of Joseph Benaquist.
Judge Robert Noonan has said that the trial is ahead of schedule, and may go to the jury as soon as Wednesday afternoon.
Plans for a concert by a famous rock star this summer have fallen through in LeRoy.
Rocker Jon Bon Jovi and his band will not be playing a concert in LeRoy, despite the efforts of LeRoy's Rotary Club and the LeRoy Business Council.
Bon Jovi's official website had never listed a concert in LeRoy for this August. Reports had indicated the concert would happen then.


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For years, 400,000 residents breathed air highly polluted by emissions from the 50-year-old coal-fired power plant operated by Calcutta Electric Supply Corporation (CESC) - the largest private thermal power company in Eastern India. The plant relied on old technology that emitted particles significantly higher than India's regulatory standard. The effects of air pollution on the health of citizens living in the area can be devastating, leading to fatal respiratory diseases and heart problems. The CESC plant, one of 81 similar coal-fired thermal power plants in India, faced increasing pressure from regulators to control air emissions or close.
USAID utilized proprietary technology from Beltran, a small New Jersey-based company, to help improve the CESC plant. To replace the 130 megawatt plant, which still has another ten years of life, with one of similar capacity would have cost about $60 million. In addition, shutting the plant down would have resulted in the loss of jobs for local residents.
To promote a productive partnership, USAID facilitated a project demonstration that led to an agreement between CESC and Beltran to install the air pollution system for all eight of its coal-fired boilers. The technology, new to India, will reduce emissions at the plant and is more efficient than the conventional equipment currently used to limit pollution generated from the plant's emissions.
Emissions from fossil fuel combustion, especially coal, are major contributors to air pollution in India. Before USAID helped revamp the plant, the city of Kolkata's air pollution levels were among the highest in the world. The air pollution control system installed in the CESC plant have reduced emissions from 500 - 1,000 to 10 - 20 micrograms per cubic meter, substantially less than the regulatory standard. CESC's 400,000 neighbors are breathing cleaner air, with markedly reduced particulate matter - the chief cause of respiratory ailments. The reduction also prevents the CESC facility from closing, saving 700 jobs of primarily local residents who depend on the plant for their livelihoods. USAID plans to share the technology with other similar coal-fired power plants in India.
Last updated: April 30, 2013


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There is a way to improve education, cut the cost of state and local government and ease the problem of school overcrowding, in one stroke.
Beginning next school year, the state of Florida could give a voucher to every new student entering the public schools.
Most students would redeem the voucher at the neighborhood public school. But enough would select a private school to begin providing more classroom space in public schools immediately.
It required some fancy footwork by legislators this year to formulate a budget for next year, given the voter mandate for class size reduction. Gov. Jeb Bush has warned that next year will be even more difficult.
Deep cuts in non-essential programs could be required.
Among the many things budget- writers have looked at are funding for the highway patrol and a program for blind babies that auditors have said is not cost- effective.
Others want to review all current tax exemptions and make greater use of trust funds for general revenue budget functions. Lastly, there is a small but vocal group aching to raise taxes.
While there is nothing in the state budget that is sacrosanct, the easiest way to preserve other programs would be to widen the state's school voucher program.
Every child who enters public school increases the burden on taxpayers. When 30 are added, a new teacher is needed. When 600 are added a multimillion-dollar new school is needed.
For about half the cost the state spends educating each child in public schools, a child's parents can choose a private school that meets their needs.
School choice has proved to be effective. There are three kinds, so far. One is the governor's program, which gives poor children a chance to escape failing schools. Another is the McKay plan, that allows children in special education to widen their choice of schools. This week, the Manhattan Institute said participants report that their McKay schools outperform their previous public schools on virtually every measure, at no additional cost to the taxpayer and little or no additional cost to their families.
The third kind of school choice is the corporate tax credit scholar- ship, which is not technically a voucher program but achieves the same objectives. It has proved so successful, it recently was expanded.
The state has assumed the duty and responsibility of educating children. There is no requirement that the education take place in government schools, however.
Where education occurs should be the parents' choice. They are the same people entrusted with making other critical decisions in a child's life, such as food, clothing and shelter. Why exclude education?
Jacksonville.com © 2017. All Rights Reserved. Contact Us


text:
Assume that you are a business owner or business professional, in a company
and industry of your choice, responsible for creating and executing the
company's strategic plan. Write a four to five (4-5) page paper in which you
- Develop an argument supporting the importance of a strategic plan for the
success of the defined business.
- Create a mission statement for the company explaining how the mission will
be essential to the company's success.
- Create a vision statement for the company explaining how the vision
statement supports the company's mission.
- Establish five (5) key objectives for the company encompassing operational,
financial, and human resource aspects of the business and justify why each of
these objectives is essential to the success of the business.
- Justify how the five (5) key objectives established support the mission and
vision statements of the company as defined in the assignment.
- Use at least four (4) quality academic resources in this assignment. Note:
Wikipedia and other Websites do not qualify as academic
Tutor Answer
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Massachusetts Institute of Technology
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Oklahoma University
2122 Tutors
Pennsylvania State University
932 Tutors
Princeton University
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Stanford University
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University of California
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Oxford University
123 Tutors
Yale University
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text:
DOUG DURAN/Staff
Cougars formidable at Las Vegas tourney
Denis Karas, pictured, helped the Campolindo High baseball team to a strong showing at the Bishop Gorman tournament in Las Vegas recently. The Cougars went 3-1, beating teams from Utah and Colorado and losing only to Damonte Ranch of Reno 6-5. The Cougars improved to 10-3 on the year. Campolindo has the week off from competition before traveling to El Cerrito for an April 15 nonleague game. Diablo Foothill Athletic League play resumes on April 17 at home against Dublin.