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ANDY DOWIE has grafted hard for seven years to get back to a level where he can face Rangers in the league.
The defender was forced to ply his trade in the lower divisions after being released by the Ibrox club in 2004.
But now he is delighted to be with Dunfermline in the SPL and relishing the chance to face them in today's live TV game.
The 28-year-old made one first-team appearance for Rangers - coincidentally against the Pars.
Last night Dowie said: "I had five good years at Rangers and it was a great experience.
"I only wish I'd worked harder because you take for granted how good facilities are at Murray Park.
"A few of the boys at Dunfermline have spent a number of years in the First Division so we're really appreciating playing at the top level and we want to stay in it for as long as we can and hopefully finish our careers in the SPL.
"It was a long, hard slog for me to get back to this stage but I've learned to look after myself better."
Dowie fears Rangers' shock midweek cup defeat by Falkirk will have them more fired up than usual.
He added: "They will look to take their frustration out on us but these are the fixtures you always look out for and we're fortunate to have a few SPL games under our belt before meeting one of the Old Firm.
"We have a decent amount of points so we'll go into it with some confidence.
"The priority for the keeper and the back four is a clean sheet and we know that will be difficult. At the other end we have players who can hurt Rangers."
Terrible The centre-half is hoping for a better result than the last time he went up against his boyhood heroes.
He said: "I played against Rangers in a cup game last season.
"It was a terrible result but a good experience and hopefully we can keep a better eye on them this time.
"We were gung-ho but 7-2 defeats can happen if you give teams such as Rangers chances.
"At the end of the day it's points not performances that matter."


text:
HP 3PAR StoreServ Storage Best Practices Guide
Finding the right storage solution is a lengthy and difficult task. This guide is aimed at system and storage administrators of all levels. HP 3PAR StoreServ storage is one of the most advanced storage platforms. It allows you to accelerate new application deployment, support server virtualization, the cloud, ITaaS, or whatever else your future may hold. Read on to discover how you can master unpredictability - without compromise.
Sponsored by HP and Intel® Xeon® Processors:
Intel, the Intel logo, Xeon, and Xeon Inside are trademarks or registered trademarks of Intel Corporation in the U.S. and/or other countries.
Provided by: Hewlett Packard Enterprise & Intel® Xeon® Processor Topic: Storage Date Added: Mar 2013 Format: PDF

subset: commoncrawl


text:
The Eagles' new defensive coordinator has his own hybrid scheme. Read »
The stats don't lie. Read »
It's official. Here is the list of Chip Kelly's assistant coaches.
The Eagles will hire veteran defensive coach Billy Davis as their next defensive coordinator, according to two league sources.
The Eagles (shockingly) on Wednesday cut tackle Demetress Bell and signed former CFL defensive end/linebacker Chris McCoy.
In our second "Who stays, who goes?" installment, Reuben Frank decided to only keep half of the Eagles' offensive players.
This rebuilding is for the long haul. Read »
A timetable of deadlines to watch for. Read »
During his introductory press conference last month, Eagles head coach Chip Kelly made sure to mention Philly's annual tradition, the Wing Bowl. Friday morning, he saw it firsthand.
Following their worst season since 1998, the Eagles are raising ticket prices for the first time in four years.


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It's nearly hump day once more and lovers of a good song and a good bloke won't want to miss tonight's Folk On the Fringe, when the wonderful Michael Waugh will be in the studio to play a few songs and chat about life and music since winning the Roddy Read Song Writing contest. Particularly appropriate with the Maldon Folk Festival coming up soon and a new musical adventure in train for the Gippsland native. If you've ever put pen to paper or finger to touch screen in the service of song writing, you might even pick up a few tips from the multi-award winner if we can get him to let his guard down. Tune in Wednesday at 7pm for this and more, including other new music.
November 2017
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text:
Westminster Christian Academy's Literary Competition Team recently returned from Winston-Salem, N.C., with several red and blue ribbons. Red ribbons were for a ranking of excellent and blue were for superior.
Red Ribbon winners
The Reader's Theatre Cast: Tim Conkel, Jameson Lakeman, Kaitlin Norman, Jessie Robinette, Austin Sayers and Haley Walters for a performance of an excerpt from "Through the Looking Glass" by Lewis Carroll.
Original Oratory: Jack Farnsworth for a speech about teenagers and evangelicalism.
Individual Acting: Meredith King for a performance of two memorized monologues.
Dramatic Interpretation: Robinette for a performance of a memorized interpretation from "A Walk to Remember" by Nicholas Sparks.
Blue Ribbon winners
Juvenile Literature Interpretation: Conkel for a reading of "Alexander and The Terrible, Horrible, No Good, Very Bad Day" by Judith Viorst and Jameson Lakeman for a reading of "Mr. Brown Can Moo- Can You?" by Dr. Seuss.
Individual Acting: Sam McClelland for a performance of two memorized monologues from "Cyrano de Bergerac" and "Julius Caesar."
Humorous Interpretation: Taylor Guisti for a performance of a memorized interpretation of "A Telephonic Conversation" by Mark Twain.
Dramatic Interpretation: Melissa Nason for a performance of a memorized monologue from "St. Joan" by George Bernard Shaw.
Biblical Literature Interpretation: Kaitlin Norman for a reading of a challenging selection from Job 38.
© 2017. All Rights Reserved. | Contact Us


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I don't even wanna think about this so let's just get to it. Extra and IMDb say... Kirstie Alley has a thing for a leading Hollywood man: "I want a booty call with Jamie Foxx -- for real," Alley dished to People magazine. "I've always had a bit of thing for him" ...... read more
Despite mountains of evidence to the contrary, people still pretend that Fergie and her crocodile skin are sexy. And who knows, maybe she is, maybe this is like Dorian Gray, and in real life she's amazing but her pictures age super fast and reflect her sins. I know... read more
Sometimes paparazzi pictures are taken from really far away, and so the pictures are real grainy or blurry. I bet the people responsible for tricking the public into thinking that girls in Hollywood actually look like they do in movies wishes this was one of those times.... read more


text: On Thu, Mar 17, 2011 at 10:58 PM, Niklas Broberg <niklas.broberg at gmail.com>wrote: > > > I already export a partial parser for top-of-file pragmas, > > > > I see. What I don't see is how such a parser would return the "rest of > input". > > Hmm. I see. And I see that you are correct in not seeing it, since it > appears it cannot be done with Happy, which I believed. It would then be > down to the parser/lexer to pass on unconsumed input, which seems a daunting > and disruptive task, seeing how the lexer typically would tokenize some > input in advance before the parser discovers that it cannot consume what has > been lexed... Hmm. > I think this is actually doable, although not necessarily easy, using a technique due to Oleg. He has used delimited continuations to take ordinary parsers and make them incremental. Dan Doel has experimented with applying the technique to Parsec parsers with some success. I think choosing the right parser monad in Happy can make this work. Reference to Oleg's technique: http://okmij.org/ftp/continuations/differentiating-parsers.html Cheers, Josef -------------- next part -------------- An HTML attachment was scrubbed... URL: <http://www.haskell.org/pipermail/haskell-cafe/attachments/20110318/a0f51db3/attachment.htm>


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- Home
- Government
- Technology Services
Technology Services
- Technology Services is a service organization tasked with keeping county business technology running effectively so that county departments can better serve the public.
- Technology Services should be prepared to meet the challenges that we see coming now.
- Part of Technology Services mission is to forecast where technology trends and practices will lead and help guide Yakima County into the future.
We welcome Gene Pugnetti as the newest member of our team. Gene will be taking over for George Helton as Technology Services Director. We currently have an opening for a Network Operations and Security Manager. That posting closes February 16th.
Services for other governmental agencies
- Secure Data Center Services
- Collocate primary or backup systems
- Hosting virtual server(s), including backup services
- Office 365 email administration
- System Administration support (For systems in use by Yakima County)
- Server support
- Workstation Support
- Network Services and Support
Our Goal
With over a thousand personal computers, phones and miles and miles of fiber optic cable, Yakima County Technology Services is striving to make Yakima County efficient, effective, and responsible to the citizens of the county.


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Chinaman in Boat With Rat on Tray
An item of great intrigue and interesting conjecture is picked to occupy 36th position in our numerical classification of the mechanical banks. This is the Chinaman In Boat With Rat On Tray and the question as to its actually being a mechanical bank made as a childrens saving device.
First let us clarify several things. Assuming it to be a recognized mechanical bank the Chinaman In Boat should be higher up in our numerical classification. That is to say it should not be down in the 36th position. It is a very rare interesting desirable item regardless of what it actually is and as a mechanical bank it is even more so. Then too since there have been only about four of the Chinaman In Boat banks turn up so far this has been the first opportunity for the writer to completely study and examine one thoroughly. Since the writer is now convinced in his opinion that it is a mechanical bank he will refer to it as such.
After considerable study and checking it is the writers opinion that the Chinaman In Boat was made by Chas. A. Bailey of Cobalt Connecticut. There are various definite earmarks and characteristics of his work, including the wording, the fine detail, the odd theme, the moon-face on the prow, and the cat, and it is made of the same lead-like material as his Springing Cat Bank and the Baby Elephant Bank Opens at X OClock.
The bank pictured was obtained by the writer through the good help of Mrs. Agnes Koehn of Cedar Rapids, Iowa. She found it in Minneapolis, Minn., in August of 1954. The lady who had the bank had found it in the home of her parents who lived near the Canadian Border. Her parents had passed away and in closing up the old home she came across the bank, and thinking it an interesting piece she decided to keep it and brought it back to Minneapolis with her.
The bank shown is in very fine condition particularly under the circumstances of the material of which it is made and the general fragile setup of the piece. It is painted attractively as follows: The Chinaman has a red jacket, yellow trousers, and he is holding a gold fan in his right hand. His queue and hair are black, his mouth red, and his face is painted a yellowish color. The bottom part of the boat is silver and the top section is a purple or raspberry color. The cat is black and the moon-face is yellow, red and silver, and the other side of the tray is gold with a silver rat on a silver platter. The inside edges of the boat are painted blue and the deck is gold, silver and yellow.
There are no identifying dates or marks on the bank as is also the case with the Springing Cat. To the best of the writers knowledge there are no patent papers covering the bank.
The wording on the bank is very interesting and a complete description is in order. On the opposite side of the cat perched on the prow is the wording I Am Seasick Oh Morrow, on the flat top deck in back of the Chinaman are the words Hotel Yacht, Free Excursion, Music By The Band Forward When It Is Not Seasick. Underneath the coin is a red half circle with Cash inscribed on it. Along with this on the movable lid is the wording Cheap Labor, Hotel Dinner One Cent In Advance. On the other side of the lid the printing reads Dinner Is Ready.
In operating the bank the coin is placed as shown, then the Chinamans queue is pressed and he raises his left forearm and flips the lid-like cover over. This causes the coin to be deposited in the hull of the boat and the lid flips on over showing a rat on the platter, a knife and fork are beside the platter. Releasing the queue causes the weight of the Chinamans forearm to flip the cover over to its original position and the bank is again ready for operation.
The Chinaman In Boat has been accepted by some collectors as being a mechanical bank and others have thought differently. It has been said that it was a special novelty item for a dinner in St. Louis or New Orleans. If this were true it is logical to assume that it would have been made in a limited number and all would have been painted alike. This is not the case, however, as the Chinaman in Mr. Leon Cametos collection is painted differently than the writers. The boat has a green bottom and the top part is painted red and there are other differences in the paint. Unquestionably the paint is original on both the writers and Mr. Cametos bank.
It has also been said that the Chinaman In Boat being an anti-Chinese item could never have been intended as a childs toy much less a bank. Well the same could be said about the Germania Exchange with the goat holding a mug of beer. It could also be said about the Breadwinners Bank which is obviously a labor-capitalist item, and who would ever think of the Baby Elephant Bank Opens At X OClock being made for a child as a toy bank with its theme of an elephant throwing a baby into an alligators mouth. Of course its to be admitted that these three banks have the name Bank imprinted on them, however, many of the banks designed by Bailey had no name on them at all. As example, the Shoot The Chute, Springing Cat, and a number of others.
Along the same line of reasoning are two toy animated cap pistols, "The Chinese Must Go" and "Shoot The Hat." These were made in the same period as the Chinaman In Boat with the same anti-Chinese theme and they are most certainly toy cap pistols made for children to use.
Another point in proof of the Chinaman being a bank is the fact that in Mr. Cametos bank there is a tin slotted piece under the revolving tray that prevents the coins from being removed by shaking the bank when held upside down. There would certainly be no point in having this part inside if it were not intended to be a savings bank. Mr. Cameto has kindly furnished the writer with this part for his bank. There was evidence of this part having been in the writers bank originally.
It might be well to explain the background of the anti-Chinese theme that was used in several of the mechanical banks and toy pistols. The mechanical banks are the Reclining Chinaman where he holds the winning card hand, all aces, and the rat is crawling from the end of the log. Then, of course, the Chinaman In Boat With Rat On Tray. The toy pistols are the Chinese Must Go, Shoot The Hat, and a single-faced and a double-faced Chinese Head cap exploder. All these toys were made for a definite reason in the period of 1879 to 1882. The background starts around 1871 when there was unrestricted Chinese labor immigration into our country. They worked for very low wages and many people felt they were destroying our labor standards and taking jobs away from our own laboring group already in our country. In 1887 there were serious outrages against the Chinese workers instigated by Dennis Kearney, the burden of whose song was The Chinese Must Go. This relates back to the Burlingame Treaty which granted the Chinese residence in America and was agreed on in 1868. In 1877 the Senate investigated the Treaty but made no changes and this set off the agitation led by Kearney and others. It wasnt until 1882 that Chinese laborers were denied admission to our country for a 10-year period. Then in 1892 the Geary Law extended these restrictions for another 10 years. So, to repeat, there is no question but that the Chinaman In Boat was made in the period of 1879 to 1882 when the anti-Chinese feeling was at its peak.
To sum up, the Chinaman In Boat With Rat On Tray is a very desirable rare item and the reader can form his own opinion as to its being a bank or not. In the writers opinion it is unquestionably an authentic toy mechanical bank made by Bailey in the period of 1879 to 1882 and that it was for sale the same as the Springing Cat Bank and the Baby Elephant Bank Opens At X OClock. Further definite proof of this may turn up in the future but this is possibly remote since Bailey made a number of his earlier banks in his own workshop in Cobalt, Connecticut, before he went with the J. & E. Stevens Company of Cromwell, Connecticut. There is very little information that exists on these earlier banks other than those that he was able to patent.
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Learn how to protect yourself from Internet scams. Read our online fraud prevention tips
Mini daschshund puppiesPuppies and Dogs For Sale Pets Classified Ad
Mini daschshund puppies
2, 11 week old Miniature Dachshund puppies available for sale, $300 each. Both parents are on site. 256-227-6771
Web Id: 16850323
Related Categories: Pets - Puppies and Dogs For Sale
Published on al.com 11/9. Updated 11/9.
Find A Local Business


text: From 121 Frontage Road and Coit Road, Plano, Texas, drive northeast on Texas-121 Frontage Road N toward Gillespie Drive. Take the ramp to your left onto Texas-121 NPartial toll road. Take the US-75 S ramp to Dallas. Keep right at the fork to continue toward US-75 S. Keep left at the fork and merge onto US-75 S. Take exit 29-29A toward Park Boulevard/15 th St/Norman F. Whitsitt Parkway. Merge onto N Central Expressway. Make a left turn onto W 15th St/Norman F Whitsett ParkwayContinue to follow W 15th St. Whispering Oaks Apartments will be on the right.


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A man told Athens-Clarke police someone broke into a utility shed on Campbell Drive and stole a pressure washer and cement cutter valued at $1,800.
According to police reports, the burglary occurred between 8 p.m. Saturday and 1 p.m. Sunday.
Published in the Athens Banner-Herald on Tuesday, September 10, 2002.
© 2017. All Rights Reserved. | Contact Us


text:
Luxury apartment accommodations for seniors will be a part of Marshall Square in Evans after developers won final rezoning approval Tuesday.
Columbia County commissioners voted unanimously – with District 3 Commissioner Charles Allen abstaining – to approve a revision to the Marshall Square zoning restrictions that limit the number of apartments that can be built on the site.
Those limits led to a $57.5 million lawsuit against the county in 2009, later settled when the county purchased 25 acres of Marshall Square.
Tuesday's vote will allow Resort Lifestyle Communities, of Lincoln, Neb., to build a 130-unit complex with an expected value of $20 million on an 8.6-acre parcel at the corner of North Belair Road and Ronald Reagan Drive.
One condition of that vote is that, if the facility is ever sold, it can't be used for anything other than as an apartment complex for residents 55 and older without rezoning, said Columbia County District 2 Commissioner Trey Allen.
The facility is part of an ambitious growth plan for the company, which currently operates nine such facilities in five states and plans to build four to six communities each year, said Josh Thornton, assistant vice president of finance for Resort Lifestyle Communities.
Those communities are self-contained, providing dining and recreational facilities for residents along with an interior "town square" of storefronts providing services to residents who live independently in individual apartments.
"We like to think of our communities as a cruise ship on land, if you will," Thornton said. "It's an all-inclusive package that you would associate with the words luxury and resort."
The three-story facility planned for Marshall Square will have about 165 residents in 130 apartments, with an anticipated average rent of about $3,000 per month, Thornton said. The "all-inclusive" price includes meals, utilities, shuttle transportation and activities.
Some of those activities will take place in the complex's 150-seat theater, which also will open occasionally for community events, Thornton said.
"One of the biggest challenges and concerns for the senior community today... is they isolate themselves and alienate from social activity when they lose a spouse or loved one," he said. "One of the things we try to do through our activities ... is to draw them out, to get them involved not only with their fellow residents but with the community."
The attraction of Marshall Square is its proximity to the Evans Town Center, Thornton said. "One of the things we love about the location is the amenities readily available from a walking perspective," including the library and Lady Antebellum Pavilion.
Columbia County Planning and Development Division Director Richard Harmon said he expects permitting for the site will be ready in a month or so.
"You're probably going to see the building coming out of the ground in May," said Paul Ritchie, the architect for the facility's contractor, Cameron General Contractors of Lincoln, Neb. Construction is expected to take about 14 months, he added.


text:
Mar 24, 2016
Red and White Wine Glasses
Red wine glasses and White wine glasses differ in shape and size, driven by the types of wine they are intended to hold. Typically Red wine glasses will be a bit taller and have a larger bowl than White wine glasses. In general Reds are bigger and bolder wines so they require a larger glass to allow all those aromas and flavors to emerge. "But do I need both types?" While you can certainly get by with one set of glasses, if you expect to drink a number of different varietals you may find that the glassware is holding back your experience, particularly if you opt to drink Red wine out of a smaller White wine glass. Does that mean you won't enjoy your wine? Most definitely not. While the various shapes and sizes can be overwhelming, a proper varietal-glass pairing can make a tremendous difference.
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GREAT DAY for a picnic last Saturday was evident on smiles of these attendees. From left are State Rep. John Sabatina, Jr., Councilman Bill Green, Local 830 chief Danny Grace, Ward Leader Bob Dellavella and Jim DiVergilis, of Local 830.
ESCORTING City Commissioner Al Schmidt, center, were Ward Leades Bill Dolbow and Bob Dellavella.
STATE SEN. Tina Tartaglione discusses Harrisburg agenda with Teamster Danny Grace and former DA candidate Dan McCaffery.
COMMITTEEMAN Dennis McClearnan has an opinion about city politics which he details to Councilman Bill Greenlee and Bill Green.
POLITICAL GOSSIP ruled conversations of attendees, all with one comment: "The food was great!†Identified in photo are State Rep. Mark Cohen and Bill Rubin.
h-7SHARING a shot with Councilwoman Marian Tasco, 2nd from left, were 35th Ward Leader Billy Dolbow, Kathy Wersinger and 53rd Ward Leader Janice Sulman.
HAPPY TIMES were evident for Councilman BillGreenlee, 63rd Ward Leader Bernice Hill, Thomas James and Pete Lyde.
DEMOCRAT Ward Leaders and elected officials, including Sheriff Jewell Williams and State Rep. John Sabatina, Jr., were on hand for annual end-of-summer gathering of Northeast Wards' annual picnic in Burholme Park.All photos by Harry Leech
LONG-TIME Committeeman Al Stuhl, left, shares this Driscoll family photo as brothers Mike and Joe join up with dad Joe Driscoll.
WARD LEADER Bill Dolbow joins up with Phil Grutzmacher, Kathy Wersinger and Tucker Mullen.
WARD LEADER Bernice Hill gets hug from everyone's favorite, Mary Frances Fogg.
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text:
At Gemvara, we believe that the jewelry you wear should be as unique as you. Every beautiful Gemvara white gold solitaire oval pink gemstone jewelry design will be made just for you. It's jewelry for all life's occasions, from an engagement or Valentine's Day to your own personal milestones and celebrations. Gemvara uses only the highest quality materials to craft your white gold solitaire oval pink gemstone jewelry with meticulous attention to detail. Our precious metals are recycled or responsibly mined. Oval-cut gemstones have excellent brilliance and appear larger than the traditional round cut. Pale 14k white gold, is the most popular white gold alloy. Because gold is naturally yellow, white gold has palladium or nickel and silver to lighten its color. Gemvara also plates our white gold with rhodium, a platinum group metal, to make it a brighter white. Our wide selection of white gold solitaire oval pink gemstone jewelry by Jessica Behzad, David West, Damon Washington, and other talented designers means you can find rings, earrings, and necklaces that are exactly your style. You can also shop by style, choosing our Florette, Streamlined, or Delicate Collections. Classic and timeless, solitaire designs are the little black dress of jewelry: simply dramatic. When our work is done and you open that box, you'll see your design is even more beautiful when brought to life in the finest precious materials.
We can help right away. Chat with a jewelry expert now!


text:
SensaSlim and Dr Ken Harvey
23 June 2011
The SensaSlim company's recent defamation suit against Dr Ken Harvey of La Trobe University highlights some of the regulatory problems facing complementary products in Australia, writes Associate Professor Cameron Stewart.
In an article co-authored with Associate Professor Ian Kerridge, they assert that SensaSlim is free to advertise and promote its products and that the Complaints Resolutions Panel (CRP), which deals with complaints about breaches of the Therapeutic Goods Advertising Code 2007, cannot investigate it for as long as the defamation action against Dr Harvey continues.
"Currently, the complaint system is the main way that these matters can be redressed but the CRP is under-resourced, overloaded and lacks effective sanctions to ensure compliance with its determinations."
View the entire article - SensaSlim goes SLAPP, public interest crusader cops a legal whack - The Conversation
Contact: Greg Sherington
Phone: +61 2 9351 0202
Email: 71053c2c1f6a210d5d5f050c395c3f0b4512350d293e660c2c00632c19


text:
Pathogenesis of Graves' disease
- Author
- Terry F Davies, MD, FRCP, FACE
Terry F Davies, MD, FRCP, FACE
- Baumritter Professor of Medicine
- Icahn School of Medicine at Mount Sinai
- Section Editor
- Douglas S Ross, MD
Douglas S Ross, MD
- Section Editor — Thyroid Disease
- Professor of Medicine
- Harvard Medical School
- Deputy Editor
- Jean E Mulder, MD
Jean E Mulder, MD
- Senior Deputy Editor — UpToDate
- Deputy Editor — Endocrinology
- Instructor in Medicine
- Harvard Medical School
Graves' disease is a syndrome that may consist of hyperthyroidism, goiter, eye disease (orbitopathy), and occasionally a dermopathy referred to as pretibial or localized myxedema. The terms Graves' disease and hyperthyroidism are not synonymous, because some patients may have orbitopathy but no hyperthyroidism, and there are many other causes of hyperthyroidism in addition to Graves' disease.
Hyperthyroidism is the most common feature of Graves' disease, affecting nearly all patients, and is caused by autoantibodies to the thyrotropin receptor (TRAb) that activate the receptor, thereby stimulating thyroid hormone synthesis and secretion as well as thyroid growth (causing a diffuse goiter). The presence of TRAb in serum and orbitopathy on clinical examination distinguishes the disorder from other causes of hyperthyroidism. Other causes of an overactive thyroid gland are discussed separately. (See "Disorders that cause hyperthyroidism".)
This topic will review the immune pathogenesis of Graves' thyroid disease, with emphasis on the role of B and T cells in the production of the TRAb that are responsible for the thyroid stimulation and growth. The pathogenesis of Graves' orbitopathy and dermopathy are reviewed separately. (See "Pathogenesis and clinical features of Graves' ophthalmopathy (orbitopathy)" and "Pretibial myxedema (thyroid dermopathy) in autoimmune thyroid disease".)
The TSH receptor — In Graves' disease, the main autoantigen is the thyroid-stimulating hormone (TSH) receptor (TSHR), which is expressed primarily in the thyroid but also in adipocytes, fibroblasts, bone cells, and a variety of additional sites [1,2]. This antigen has been reviewed extensively elsewhere (figure 1) [1,2]. The TSHR is a G-protein coupled receptor with seven transmembrane-spanning domains. TSH, acting via the TSHR, regulates thyroid growth and thyroid hormone production and secretion. The TSHR undergoes complex posttranslational processing involving dimerization and intramolecular cleavage; the latter modification leaves a two-subunit structural form of the receptor. Data suggest that there is eventual shedding or degradation of the TSHR ectodomain [3], although this has not been demonstrated in vivo. Each of these posttranslational events may influence the antigenicity of the receptor. However, factors that contribute to TSHR presentation as a target for the immune system in humans are not well understood but are considered to be primarily factors that build on a state of enhanced genetic susceptibility. Such susceptibility may be translated by variable expression of the TSHR on thymic epithelial cells, which is of great importance in determining self-tolerance [4,5].
The thyroid gland in Graves' disease — The thyroid is usually, but not always, diffusely enlarged. The histology of the thyroid gland in patients with Graves' hyperthyroidism is characterized by follicular hyperplasia, intracellular colloid droplets, cell scalloping, a reduction in follicular colloid, and a patchy (multifocal) lymphocytic infiltration. Only rarely are lymphoid germinal centers seen. The histological picture may be greatly influenced by pretreatment with antithyroid drugs (picture 1). The majority of intrathyroidal lymphocytes are T cells but plenty of B cells may be present, though nothing like that seen in chronic autoimmune thyroiditis (Hashimoto's disease). In some areas, thyroid epithelial cell size correlates with the intensity of the lymphocytic infiltrate, suggesting thyroid-cell stimulation by local B cells secreting stimulating TRAb [6].To continue reading this article, you must log in with your personal, hospital, or group practice subscription. For more information on subscription options, click below on the option that best describes you:
Subscribers log in hereLiterature review current through: Oct 2017. | This topic last updated: Nov 14, 2017.The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The use of this website is governed by the UpToDate Terms of Use ©2017 UpToDate, Inc.References
- Davies TF, Ando T, Lin RY, et al. Thyrotropin receptor-associated diseases: from adenomata to Graves disease. J Clin Invest 2005; 115:1972.
- Latif R, Morshed SA, Zaidi M, Davies TF. The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling. Endocrinol Metab Clin North Am 2009; 38:319.
- Chazenbalk GD, Pichurin P, Chen CR, et al. Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. J Clin Invest 2002; 110:209.
- Colobran R, Armengol Mdel P, Faner R, et al. Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance. Hum Mol Genet 2011; 20:3415.
- Stefan M, Wei C, Lombardi A, et al. Genetic-epigenetic dysregulation of thymic TSH receptor gene expression triggers thyroid autoimmunity. Proc Natl Acad Sci U S A 2014; 111:12562.
- Paschke R, Brückner N, Eck T, et al. Regional stimulation of thyroid epithelial cells in Graves' disease by lymphocytic aggregates and plasma cells. Acta Endocrinol (Copenh) 1991; 125:459.
- McLachlan SM, Pegg CA, Atherton MC, et al. TSH receptor antibody synthesis by thyroid lymphocytes. Clin Endocrinol (Oxf) 1986; 24:223.
- Adams DD, Purves HD. Abnormal responses in the assay of thyrotropin. Proceedings of the University of Otago Medical School 1956; 34:11.
- Smith BR, Hall R. Thyroid-stimulating immunoglobulins in Graves' disease. Lancet 1974; 2:427.
- Adams DD, Fastier FN, Howie JB, et al. Stimulation of the human thyroid by infusions of plasma containing LATS protector. J Clin Endocrinol Metab 1974; 39:826.
- McKenzie JM, Zakarija M. Fetal and neonatal hyperthyroidism and hypothyroidism due to maternal TSH receptor antibodies. Thyroid 1992; 2:155.
- Massart C, Gibassier J, d'Herbomez M. Clinical value of M22-based assays for TSH-receptor antibody (TRAb) in the follow-up of antithyroid drug treated Graves' disease: comparison with the second generation human TRAb assay. Clin Chim Acta 2009; 407:62.
- Zöphel K, Roggenbuck D, von Landenberg P, et al. TSH receptor antibody (TRAb) assays based on the human monoclonal autoantibody M22 are more sensitive than bovine TSH based assays. Horm Metab Res 2010; 42:65.
- Lytton SD, Kahaly GJ. Bioassays for TSH-receptor autoantibodies: an update. Autoimmun Rev 2010; 10:116.
- Shimojo N, Kohno Y, Yamaguchi K, et al. Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci U S A 1996; 93:11074.
- Kita M, Ahmad L, Marians RC, et al. Regulation and transfer of a murine model of thyrotropin receptor antibody mediated Graves' disease. Endocrinology 1999; 140:1392.
- Costagliola S, Many MC, Denef JF, et al. Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease. J Clin Invest 2000; 105:803.
- Nagayama Y, Kita-Furuyama M, Ando T, et al. A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J Immunol 2002; 168:2789.
- Weetman AP, Yateman ME, Ealey PA, et al. Thyroid-stimulating antibody activity between different immunoglobulin G subclasses. J Clin Invest 1990; 86:723.
- Davies TF, Yeo PP, Evered DC, et al. Value of thyroid-stimulating-antibody determinations in predicting short-term thyrotoxic relapse in Graves' disease. Lancet 1977; 1:1181.
- Wilson R, McKillop JH, Henderson N, et al. The ability of the serum thyrotrophin receptor antibody (TRAb) index and HLA status to predict long-term remission of thyrotoxicosis following medical therapy for Graves' disease. Clin Endocrinol (Oxf) 1986; 25:151.
- Davies TF, Roti E, Braverman LE, DeGroot LJ. Thyroid controversy--stimulating antibodies. J Clin Endocrinol Metab 1998; 83:3777.
- Feldt-Rasmussen U, Schleusener H, Carayon P. Meta-analysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves' disease. J Clin Endocrinol Metab 1994; 78:98.
- Saito T, Endo T, Kawaguchi A, et al. Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab 1997; 82:3331.
- Vassart G, Dumont JE. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev 1992; 13:596.
- Kleinau G, Jaeschke H, Worth CL, et al. Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor. PLoS One 2010; 5:e9745.
- Aizawa Y, Yoshida K, Kaise N, et al. Long-term effects of radioiodine on thyrotrophin receptor antibodies in Graves' disease. Clin Endocrinol (Oxf) 1995; 42:517.
- Laurberg P, Wallin G, Tallstedt L, et al. TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. Eur J Endocrinol 2008; 158:69.
- Morshed SA, Latif R, Davies TF. Characterization of thyrotropin receptor antibody-induced signaling cascades. Endocrinology 2009; 150:519.
- Morshed SA, Ando T, Latif R, Davies TF. Neutral antibodies to the TSH receptor are present in Graves' disease and regulate selective signaling cascades. Endocrinology 2010; 151:5537.
- Núñez Miguel R, Sanders J, Chirgadze DY, et al. Thyroid stimulating autoantibody M22 mimics TSH binding to the TSH receptor leucine rich domain: a comparative structural study of protein-protein interactions. J Mol Endocrinol 2009; 42:381.
- Nagayama Y. Continuous versus discontinuous B-cell epitopes on thyroid-specific autoantigens--thyrotropin receptor and thyroid peroxidase. Eur J Endocrinol 1995; 132:9.
- Vlase H, Graves PN, Magnusson RP, Davies TF. Human autoantibodies to the thyrotropin receptor: recognition of linear, folded, and glycosylated recombinant extracellular domain. J Clin Endocrinol Metab 1995; 80:46.
- Nagayama Y, Rapoport B. Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: selective role of receptor amino acids Ser25-Glu30. J Clin Endocrinol Metab 1992; 75:1425.
- Ando T, Latif R, Daniel S, et al. Dissecting linear and conformational epitopes on the native thyrotropin receptor. Endocrinology 2004; 145:5185.
- Feig C, Peter ME. How apoptosis got the immune system in shape. Eur J Immunol 2007; 37 Suppl 1:S61.
- Bossowski A, Czarnocka B, Bardadin K, et al. Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis. Autoimmunity 2008; 41:163.
- Tamai H, Kasagi K, Takaichi Y, et al. Development of spontaneous hypothyroidism in patients with Graves' disease treated with antithyroidal drugs: clinical, immunological, and histological findings in 26 patients. J Clin Endocrinol Metab 1989; 69:49.
- Takasu N, Yamada T, Sato A, et al. Graves' disease following hypothyroidism due to Hashimoto's disease: studies of eight cases. Clin Endocrinol (Oxf) 1990; 33:687.
- Kraiem Z, Baron E, Kahana L, et al. Changes in stimulating and blocking TSH receptor antibodies in a patient undergoing three cycles of transition from hypo to hyper-thyroidism and back to hypothyroidism. Clin Endocrinol (Oxf) 1992; 36:211.
- Tamai H, Ohsako N, Takeno K, et al. Changes in thyroid function in euthyroid subjects with a family history of Graves' disease: a follow-up study of 69 patients. J Clin Endocrinol Metab 1980; 51:1123.
- Salvi M, Vannucchi G, Campi I, Beck-Peccoz P. Rituximab in the treatment of thyroid eye disease: science fiction? Orbit 2009; 28:251.
- Hegedüs L, Smith TJ, Douglas RS, Nielsen CH. Targeted biological therapies for Graves' disease and thyroid-associated ophthalmopathy. Focus on B-cell depletion with Rituximab. Clin Endocrinol (Oxf) 2011; 74:1.
- Mills KH. Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol 2004; 4:841.
- Watson PF, Pickerill AP, Davies R, Weetman AP. Analysis of cytokine gene expression in Graves' disease and multinodular goiter. J Clin Endocrinol Metab 1994; 79:355.
- Rapoport B, McLachlan SM. Graves' hyperthyroidism is antibody-mediated but is predominantly a Th1-type cytokine disease. J Clin Endocrinol Metab 2014; 99:4060.
- Stassi G, Di Liberto D, Todaro M, et al. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Nat Immunol 2000; 1:483.
- Hiromatsu Y, Hoshino T, Yagita H, et al. Functional Fas ligand expression in thyrocytes from patients with Graves' disease. J Clin Endocrinol Metab 1999; 84:2896.
- Mackenzie WA, Davies TF. An intrathyroidal T-cell clone specifically cytotoxic for human thyroid cells. Immunology 1987; 61:101.
- Ban Y, Davies TF, Greenberg DA, et al. Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease. Genes Immun 2004; 5:203.
- Lohr J, Knoechel B, Abbas AK. Regulatory T cells in the periphery. Immunol Rev 2006; 212:149.
- Coles AJ, Wing M, Smith S, et al. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet 1999; 354:1691.
- Ward DL, Bing-You RG. Autoimmune thyroid dysfunction induced by interferon-alpha treatment for chronic hepatitis C: screening and monitoring recommendations. Endocr Pract 2001; 7:52.
- Fainboim L, Arruvito L. Mechanisms involved in the expansion of Tregs during pregnancy: role of IL-2/STAT5 signalling. J Reprod Immunol 2011; 88:93.
- Fields BA, Mariuzza RA. Structure and function of the T-cell receptor: insights from X-ray crystallography. Immunol Today 1996; 17:330.
- Davies TF, Martin A, Concepcion ES, et al. Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N Engl J Med 1991; 325:238.
- Davies TF, Concepcion ES, Ben-Nun A, et al. T-cell receptor V gene use in autoimmune thyroid disease: direct assessment by thyroid aspiration. J Clin Endocrinol Metab 1993; 76:660.
- Heufelder AE, Wenzel BE, Scriba PC. Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease. J Clin Endocrinol Metab 1996; 81:3733.
- Nakashima M, Martin A, Davies TF. Intrathyroidal T cell accumulation in Graves' disease: delineation of mechanisms based on in situ T cell receptor analysis. J Clin Endocrinol Metab 1996; 81:3346.
- Jansson R, Dahlberg PA, Winsa B, et al. The postpartum period constitutes an important risk for the development of clinical Graves' disease in young women. Acta Endocrinol (Copenh) 1987; 116:321.
- Davis MM, Buxbaum J. T-cell receptor use in human autoimmune diseases, New York Academy of Sciences, New York 1995.
- Martin A, Barbesino G, Davies TF. T-cell receptors and autoimmune thyroid disease--signposts for T-cell-antigen driven diseases. Int Rev Immunol 1999; 18:111.
- Mao C, Wang S, Xiao Y, et al. Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease. J Immunol 2011; 186:4734.
- Pan D, Shin YH, Gopalakrishnan G, et al. Regulatory T cells in Graves' disease. Clin Endocrinol (Oxf) 2009; 71:587.
- Schwartz RH. T cell anergy. Sci Am 1993; 269:62.
- Arnold B, Schönrich G, Hämmerling GJ. Multiple levels of peripheral tolerance. Immunol Today 1993; 14:12.
- Srinivasappa J, Saegusa J, Prabhakar BS, et al. Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. J Virol 1986; 57:397.
- Wenzel BE, Heesemann J, Wenzel KW, Scriba PC. Antibodies to plasmid-encoded proteins of enteropathogenic Yersinia in patients with autoimmune thyroid disease. Lancet 1988; 1:56.
- Brix TH, Hansen PS, Hegedüs L, Wenzel BE. Too early to dismiss Yersinia enterocolitica infection in the aetiology of Graves' disease: evidence from a twin case-control study. Clin Endocrinol (Oxf) 2008; 69:491.
- Burch HB, Nagy EV, Lukes YG, et al. Nucleotide and amino acid homology between the human thyrotropin receptor and the HIV-1 Nef protein: identification and functional analysis. Biochem Biophys Res Commun 1991; 181:498.
- Heufelder AE, Goellner JR, Wenzel BE, Bahn RS. Immunohistochemical detection and localization of a 72-kilodalton heat shock protein in autoimmune thyroid disease. J Clin Endocrinol Metab 1992; 74:724.
- Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983; 2:1115.
- Hammerstad SS, Stefan M, Blackard J, et al. Hepatitis C Virus E2 Protein Induces Upregulation of IL-8 Pathways and Production of Heat Shock Proteins in Human Thyroid Cells. J Clin Endocrinol Metab 2017; 102:689.
- Kawakami Y, Kuzuya N, Watanabe T, et al. Induction of experimental thyroiditis in mice by recombinant interferon gamma administration. Acta Endocrinol (Copenh) 1990; 122:41.
- Neufeld DS, Platzer M, Davies TF. Reovirus induction of MHC class II antigen in rat thyroid cells. Endocrinology 1989; 124:543.
- Khoury EL, Pereira L, Greenspan FS. Induction of HLA-DR expression on thyroid follicular cells by cytomegalovirus infection in vitro. Evidence for a dual mechanism of induction. Am J Pathol 1991; 138:1209.
- Londei M, Lamb JR, Bottazzo GF, Feldmann M. Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 1984; 312:639.
- Kimura H, Davies TF. Thyroid-specific T cells in the normal Wistar rat. II. T cell clones interact with cloned wistar rat thyroid cells and provide direct evidence for autoantigen presentation by thyroid epithelial cells. Clin Immunol Immunopathol 1991; 58:195.
- Horwitz MS, Bradley LM, Harbertson J, et al. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat Med 1998; 4:781.
- Arata N, Ando T, Unger P, Davies TF. By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse. Clin Immunol 2006; 121:108.
- Stenszky V, Kozma L, Balázs C, et al. The genetics of Graves' disease: HLA and disease susceptibility. J Clin Endocrinol Metab 1985; 61:735.
- Tomer Y, Ban Y, Concepcion E, et al. Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am J Hum Genet 2003; 73:736.
- Tomer Y, Davies TF. Searching for the autoimmune thyroid disease susceptibility genes: from gene mapping to gene function. Endocr Rev 2003; 24:694.
- Villanueva R, Greenberg DA, Davies TF, Tomer Y. Sibling recurrence risk in autoimmune thyroid disease. Thyroid 2003; 13:761.
- Heward JM, Allahabadia A, Armitage M, et al. The development of Graves' disease and the CTLA-4 gene on chromosome 2q33. J Clin Endocrinol Metab 1999; 84:2398.
- Chen QY, Huang W, She JX, et al. HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective. J Clin Endocrinol Metab 1999; 84:3182.
- Jacobson EM, Huber A, Tomer Y. The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology. J Autoimmun 2008; 30:58.
- Ho SC, Goh SS, Khoo DH. Association of Graves' disease with intragenic polymorphism of the thyrotropin receptor gene in a cohort of Singapore patients of multi-ethnic origins. Thyroid 2003; 13:523.
- Hiratani H, Bowden DW, Ikegami S, et al. Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease. J Clin Endocrinol Metab 2005; 90:2898.
- Yin X, Latif R, Bahn R, et al. Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy. Thyroid 2008; 18:1201.
- Davies TF, Yin X, Latif R. The genetics of the thyroid stimulating hormone receptor: history and relevance. Thyroid 2010; 20:727.
- Ban Y, Greenberg DA, Concepcion E, et al. Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease. Proc Natl Acad Sci U S A 2003; 100:15119.
- Menconi F, Hasham A, Tomer Y. Environmental triggers of thyroiditis: hepatitis C and interferon-α. J Endocrinol Invest 2011; 34:78.
- Tomer Y, Davies TF. Infection, thyroid disease, and autoimmunity. Endocr Rev 1993; 14:107.
- Humphrey M, Mosca J, Baker JR Jr, et al. Absence of retroviral sequences in Graves' disease. Lancet 1991; 337:17.
- Neumann-Haefelin D, Fleps U, Renne R, Schweizer M. Foamy viruses. Intervirology 1993; 35:196.
- Sonino N, Girelli ME, Boscaro M, et al. Life events in the pathogenesis of Graves' disease. A controlled study. Acta Endocrinol (Copenh) 1993; 128:293.
- Kung AW. Life events, daily stresses and coping in patients with Graves' disease. Clin Endocrinol (Oxf) 1995; 42:303.
- Matos-Santos A, Nobre EL, Costa JG, et al. Relationship between the number and impact of stressful life events and the onset of Graves' disease and toxic nodular goitre. Clin Endocrinol (Oxf) 2001; 55:15.
- Kincade PW, Medina KL, Smithson G, Scott DC. Pregnancy: a clue to normal regulation of B lymphopoiesis. Immunol Today 1994; 15:539.
- Paavonen T. Hormonal regulation of immune responses. Ann Med 1994; 26:255.
- Da Silva JA. Sex hormones, glucocorticoids and autoimmunity: facts and hypotheses. Ann Rheum Dis 1995; 54:6.
- Yin X, Latif R, Tomer Y, Davies TF. Thyroid epigenetics: X chromosome inactivation in patients with autoimmune thyroid disease. Ann N Y Acad Sci 2007; 1110:193.
- Markle JG, Frank DN, Mortin-Toth S, et al. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 2013; 339:1084.
- Prummel MF, Wiersinga WM. Smoking and risk of Graves' disease. JAMA 1993; 269:479.
- Holm IA, Manson JE, Michels KB, et al. Smoking and other lifestyle factors and the risk of Graves' hyperthyroidism. Arch Intern Med 2005; 165:1606.
- Bartalena L, Tanda ML. Clinical practice. Graves' ophthalmopathy. N Engl J Med 2009; 360:994.
- Stan MN, Bahn RS. Risk factors for development or deterioration of Graves' ophthalmopathy. Thyroid 2010; 20:777.
- Weetman AP. Immunity, thyroid function and pregnancy: molecular mechanisms. Nat Rev Endocrinol 2010; 6:311.
- Stagnaro-Green A. Postpartum thyroiditis. Best Pract Res Clin Endocrinol Metab 2004; 18:303.
- Ando T, Davies TF. Clinical Review 160: Postpartum autoimmune thyroid disease: the potential role of fetal microchimerism. J Clin Endocrinol Metab 2003; 88:2965.
- Bartalena L, Bogazzi F, Martino E. Amiodarone-induced thyrotoxicosis: a difficult diagnostic and therapeutic challenge. Clin Endocrinol (Oxf) 2002; 56:23.
- Burikhanov RB, Matsuzaki S. Excess iodine induces apoptosis in the thyroid of goitrogen-pretreated rats in vivo. Thyroid 2000; 10:123.
- Mandac JC, Chaudhry S, Sherman KE, Tomer Y. The clinical and physiological spectrum of interferon-alpha induced thyroiditis: toward a new classification. Hepatology 2006; 43:661.
- Aranha AA, Amer S, Reda ES, et al. Autoimmune thyroid disease in the use of alemtuzumab for multiple sclerosis: a review. Endocr Pract 2013; 19:821.
- The TSH receptor
- The thyroid gland in Graves' disease
- Autoantibodies to the TSH receptor
- Influence of radioiodine on TRAb
- Different types of TRAb
- Binding sites for TRAb
- Relationship with autoimmune thyroiditis
- Modifying the B cell repertoire
- Mechanisms of T cell activation
- Changing the T cell population
- Intrathyroidal T cell receptor V gene repertoire
- The role of suppressor effects of T cells
- Molecular mimicry
- Thyroid cell expression of HLA molecules
- Bystander activation
- Genetic susceptibility
- Infection
- Stress
- Gender
- Smoking
- Pregnancy
- Drugs


text:
If you haven't already, check out the healing library. There is a lot of helpful information there.
Is your husband showing you remorse and transparency? How is he helping you through your rough days?
He has been a different person since all of this, open, patient, caring, has did everything I asked and answered every question I've posed. I just want off this merry go round! The ups and downs are enough to drive someone mad. I can be completely fine and then fall apart. It's absolutely insane.
Welcome to SI! Sorry you had to find us but you'll find amazing strength and support here.
Your feelings are going to be this way for quite some time to come - sadly.
On average it takes two to five years to recover from infidelity.
You haven't mentioned where the OW is in this picture?
Keep posting, it helps.
It is all so very new and raw.
You are in shock. Your world has been turned upside down.
It is completely normal to feel everything and all at once. We call it the rollercoaster from hell.
I provide you with the timeline to let you know that it is normal for you to hurt and vacillate for sometime. It helps to put it in context and to try not to speed up your healing. You have to go through it not "get over it"
Your mind can only absorb so much trauma. Deep breaths and know that we are all here for you.
Good luck
Timeline of Recovery
Good timeline I found on another site...Hope this helps..
Q: How Long Will It Take Me To Heal From This?
A: There is no set time line. On the average it's 1-2 years to heal from betrayal. 3-5 years is not out of the norm.
Below is a general guide, not everyone heals in the same amount of time as others, there are variables to consider in each individual's situation. It's a rollercoaster ride, emotionally and physically, but I promise you - you can and will survive. But, you will never be the same and that's not always a bad thing.
D-day to 6 months is devastation; you're done with life, in shock and sick at heart. You are raw emotionally and never knew such despair could be felt.
6-9 months are full of mood swings from "it's going to be okay" to "Why am I even trying." Your thoughts are emotion driven and not dependable.
9-12 months you can actually go about 15 minutes without thinking about "it." One morning I stepped out of the shower and realized that I hadn't thought of the affair yet. But sadly, those times were few and far between. You're still up and down emotionally.
Then at 12 months, sobbing again with the disappointment in your spouses selfishness
14 months you are able to have a heartfelt happy moment.
18 months the incredible crush of despair is gone. You wake up one morning and realize that the A was something that happened, not something that is happening.
20 months you no longer feel like your world is in danger. Trusting again, with your heart if not with your brain. Constantly questioning your own feelings but you realize it is fear stalking you now, not danger.
22 months you can see a future. You don't cry at the drop of a hat. You can watch television without falling apart at a love scene. Actually feeling almost back to your normal self. You finally loose that sense of being "outside" yourself. The phases can trick you, you think you're doing great at five weeks and then you hit the bottom of the well at 12 weeks. You can be raging at 10 months with a horrible anger that never appeared early on.
One day at a time...keep moving....be kind and patient with yourself.
I am almost exactly a year a head of you. I have 4 kids. My WH's A consisted of a drunken makeout session with MOW, no contact for 8 months and then an 8 month PA/EA.
I know what you are going through now and what you will go through during the next year.
Is OW married? You should tell her BH if she is.
Is your WH totally transparent with you? Do you have full access to his phone? Computer? Passwords to all of his email, skyp, google+, Facebook, etc accounts?
This is important for you to have. Part of rebuilding your trust in him is your ability to look through all of these things WHENEVER you want and see that nothing suspicious is there.
At SI we use the phrase "trust but verify". If he says he isn't calling or texting her, trust that but still check the phone bill and his phone. If he has told the truth it will make a deposit in the trust bank that is currently severely overdrawn.
Your emotions will be all over the place for a while. You will have days where you will function almost normal and others where you just want to curl up in a ball in a dark closet and cry. That is normal.
Gradually, if your spouse is remorseful and behaving properly, you will have more and more moments of feeling normal. Eventually you will have hours of normal.
I found that the more I was out of the house doing things, the better I was.
Warning: After floating along sad but otherwise feeling better pulled together, at about 6 and 9 months I was hit with some pretty intense rage days. I would highly recommend that you ask him to take and hide any precious mementoes you might be tempted to smash.
Read the Healing Library located in the yellow box on this page. Read the other threads so you can see what you are feeling is very normal and so you can see what kind of emotions you can expect in the future.
I hope for a happy ending for you, and I do think it's better to know the truth. Don't deny any feelings that you're having. This too will pass.
The OW is single, and did I mention 14 years younger?
The age doesn't make a difference. You wouldn't feel any better if your WH threw away you and your 4 kids for the twin of Alfred E Neuman in drag who was the same age as you. I would know.
The one thing all OW have in common, if they know your WH is married, is they are broken individuals. WS have to find someone broken, because someone with healthy self-esteem would never knowingly get involved with a married person.
So when you start getting upset over the "who" he A-ed with. Remember she has at least one pretty significant personality flaw.
In most cases, you eventually find the "who" could have been any one. Usually, it is just that the AP was willing.


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The racial composition of the Dallas County Sheriff's Department command staff — the top group of chief deputies and assistant chief deputies — has ignited a dispute between two of the county's most prominent Democrats.
County Commissioner John Wiley Price is battling Sheriff Lupe Valdez, a fellow Democrat, over her promotion of a white man to an assistant chief deputy position that had been previously held by a black woman.
Price, who is black, fumed in an interview that the Sheriff's Department's seven-person command staff would then have only one African-American — Chief Deputy Marlin Suell — for what he said was the first time in about three decades.
"It's unacceptable," Price said in what he described as the "note card" version of the discussion he plans to have next week at Commissioners Court.
'Best qualified person'
Valdez, who is Hispanic, declined to be interviewed. In a prepared statement, she said, "We appreciate Commissioner Price's concern and understand his frustration since we share the mission to continuously promote diversity and inclusion.
"I never want to be the person that promotes injustice and inequality," Valdez said. "I have selected the best qualified person."
Valdez's statement did not include details on steps she might have taken to develop a diverse pool of applicants. It also didn't say whether she posted the job opening internally or if she considered any other internal candidates.
The disagreement first came to light on Tuesday at the regular meeting of the Dallas County Commissioners Court.
County elected officials make their own personnel moves. But county commissioners must give their approval to the corresponding salary movements — and effectively, the decisions themselves. That usually happens on the consent agenda without much debate.
On Tuesday, however, Price said he wanted to discuss the promotion in the Sheriff's Department of Capt. Jason Hartgraves.
Hartgraves, who's been with the department since 1990, was chosen to oversee the Technical Services Bureau, effective in early October. That assistant chief position came open in September, after Cheryl Wilson was named Lancaster police chief.
County Judge Clay Jenkins told Price that the matter should be discussed in a closed session, since it involved a personnel issue. Loud shouting could later be heard from the closed session, and a decision on the salary increase was postponed for at least a week.
"I'm just livid," Price later explained.
The spat is unusual.
Price and Valdez have worked together on many issues, most notably improving the county jail. As prominent minority elected officials — and fellow Democrats — the two have also supported each other in their respective elections.
But Price said that collaboration only made Valdez's decision more galling. He said it was "nuts" that Valdez was bucking a long-standing, albeit unwritten, standard of having two African-Americans on the command staff.
'Glass ceiling'
Price said there is a "glass ceiling" in that respect, and "you knew we weren't going to have three or four" African-Americans on the command staff. But he said he thought Valdez would at least do the same as her Republican predecessors.
And the commissioner, who represents most of southern Dallas County, said Valdez should be more sensitive to the black support that helped get her elected in 2004 and re-elected twice since then.
"Do the right thing," Price said. "You know who got you elected, and then you go outside of that."
It's unclear what will happen Tuesday when Price plans to raise the issue again at Commissioners Court. But Valdez can count on strong support from Republican County Commissioner Mike Cantrell, who represents most of northern Dallas County.
Cantrell apparently provided much of the pushback against Price in the closed session. And he later explained he was "astonished" there would be an effort to micromanage an elected official's personnel decisions, especially by injecting race into the discussion.
"You have an elected official that has a command staff where she knows exactly what she needs in that position," he said. "She has watched these people come up the ranks. She knows their capabilities, their qualities, their background, their education."
Cantrell said the promotion was a "no-brainer," given the candidate's qualifications. He said Valdez has a "game plan" and that the sheriff's background gives her particular insight into "what needs to be done to advance minorities."
And in any case, Cantrell said, the county doesn't have a racial quota system.
"So you're telling an elected official, 'Once you move an Anglo, Hispanic or black into a managerial position, you cannot replace that person with any other person of any different color'?" Cantrell said. "I just don't see that."
Follow Tom Benning on Twitter at @tombenning.


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KingsIsle Entertainment Reveals The Lost World Of Azteca In Wizard101
Nov 12, 2012, 10:26 ET from KingsIsle Entertainment
PLANO, Texas, Nov. 12, 2012 /PRNewswire/ -- The lost world of Azteca has been discovered once again in the magical realm of Wizard101. Home to the Aztecosaurs, the oldest living race in the Wizard101 universe, the fate of Azteca hangs in a perilous balance.
(Logo: http://photos.prnewswire.com/prnh/20100526/KINGSISLELOGO)
Azteca is a high-level world of ancient dinosaurs, hidden temples, and cosmic significance. Wizards will take on mighty foes and gain new heights of power as they race against the doomsday clock to save the Aztecosaurs and their home world.
"In Azteca, Wizards will face challenges and consequences on a scale they've never encountered before in Wizard101," said Todd Coleman, vice president and creative director at KingsIsle Entertainment. "While we've always known that the archvillain Morganthe is up to no good—in Azteca the stakes become crystal clear."
Azteca includes:
- New Azteca-themed epic spells for each school of magic
- Powerful Astral spells that can be used by high-level Wizards
- 13 challenging zones to explore and conquer
- The opportunity to reach level 90 and achieve the rank of Promethean Wizard
- A new crafting tier and a variety of useful new recipes
- Powerful gear, talented pets, and ferocious new mounts!
The complete set of update notes for Azteca can be found here:
About KingsIsle Entertainment, Inc.
KingsIsle Entertainment is a developer and publisher that specializes in creating high-quality online games which provide entertainment for the entire family. KingsIsle games have received numerous honors, including the Parent Tested Parent Approved Media Seal and recognition by the National Parenting Publications Awards. KingsIsle's first game, Wizard101, was named Best MMO of 2010 by Beckett Massive Online Gamer Magazine, Best Family MMO of the Decade by Massively.com and the #1 Best Family Game of 2009 by MMORPG.com. KingsIsle is headquartered in Plano, Texas, and has a development studio in Austin, Texas. Information about the company's games, which include core titles Wizard101 and Pirate101, can be found at http://www.kingsisle.com/corporate/products.
KingsIsle, Wizard101 and Pirate101 are trademarks or registered trademarks of KingsIsle Entertainment Inc.
SOURCE KingsIsle Entertainment


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Step 1: Enable Remi Repository phpMyAdmin most updated package is available under remi repository. Install it in your system using following commands. CentOS/RHEL 7: # rpm -Uvh http://rpms.famillecollet.com/enterprise/remi-release-7.rpm CentOS/RHEL 6: # rpm -Uvh http://rpms.famillecollet.com/enterprise/remi-release-6.rpm CentOS/RHEL 5: # rpm -Uvh http://rpms.famillecollet.com/enterprise/remi-release-5.rpm Fedora 20: # rpm -Uvh http://rpms.famillecollet.com/remi-release-20.rpm Fedora 19: # rpm -Uvh http://rpms.famillecollet.com/remi-release-19.rpm Fedora 18: # ..
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Acura's RDX got a new engine and a new transmission in its redesign for model year 2013. The new drivetrain results in much better mileage, and all the smart technology you expect from Acura remains. The RDX, an entry-level midsize premium SUV, seats five comfortably and wins a "Top Safety Pick" rating from the Insurance Institute for Highway Safety.
The RDX gets a boost of 33 horsepower from its new 3.5-liter V-6 engine, compared to the 2012's 2.3-liter 4-cylinder. The V-6 also uses variable cylinder management, meaning three of the engine's six cylinders are deactivated when less power is needed. The result is that the 2013 RDX has mileage estimates of 19 miles per gallon in the city and 27 mpg on the highway for the AWD. It's an increase of 5 mpg over the 2012 model. The front-wheel drive RDX gets one mpg better in the city and on the highway.
Our test RDX had the only optional package available: the Technology Package which adds the Acura Link Satellite Communications System, navigation with voice recognition and real time traffic and weather, a new 10-speaker sound system with 410 watts, XM Satellite Radio, Bluetooth connectivity, dual-zone automatic climate control and a power operated rear hatch. Standard features include leather upholstery, pushbutton start and a backup camera.
The RDX has more passenger and cargo room, even though the vehicle is only an inch longer overall. The cabin is in what Acura calls a "dual personal cockpit" design with bucket seats up front and a 60/40 split-folding rear seat. With the second row seatbacks folded down, the RDX has 76.9 cubic feet of storage. The total passenger volume is 103.5 cubic feet. Though the RDX is midsized, it just feels bigger inside. And it's got all the luxury you'd expect. Our test RDX was in the Crystal Black Pearl color with a cream colored leather interior.
The test vehicle was also equipped with an AWD drivetrain that is lighter and more sophisticated than the previous version. The 6-speed automatic transmission with sequential shift and paddle shifters on the steering wheel shifted smoothly throughout the range of gears. The transmission replaces the 5-speed on the previous model.
The ride in the RDX is refined and comfortable thanks primarily to a 4-wheel independent suspension. The electronic power steering was precise, but there was some body roll in hard cornering. Braking was excellent and the cabin was very quiet thanks to added insulation and other soundproofing.
When it comes to safety, the 2013 Acura RDX has received a "Top Safety Pick" from the Insurance Institute for Highway Safety, garnering the IIHS top score of "good" in each category.
The redesigned 2013 Acura RDX with the Technology Package stickered at $39,420. Add $895 in destination charges and the bottom line was $40,315. Acura says the target audience for the RDX is young professionals in their 30s just starting families, but still wanting a sportier driving experience.
2013 Acura RDX
Engine: 3.5-liter V-6 with variable cylinder management
Transmission: AWD 6-speed automatic with sequential shifting
Horsepower: 273
Test model base price: $39,420
EPA mileage rating: 19 mpg city / 27 mpg highway (AWD)


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Precious metals and their alloys and goods in precious metals or coated therewith, namely, jewelry, precious gemstones, namely, diamonds and horological and chronometric instruments, namely, hand wrist watches, pocket watches and watch pendants
Business in Johannesburg Gauteng, ZA


text: I Won't Love Him Any More Me Too Personal Stories, Advice, and Support 5 People Report Group Sort popular recent A Lonely first of all I am a bad writer So please I apologize for my grammar but I need help. I am very sad write not I don't and I HATE NOT working. I don't have any one to talk to... AnnieWy 36-40 1 Response 0 Jan 15, 2009 More Stories


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Derek Jarman
1 portrait of Derek Jarman
© reserved; collection National Portrait Gallery, London
Derek Jarman
by Richard Hamilton
pigment transfer, 1996-1997
15 3/8 in. x 15 3/8 in. (390 mm x 390 mm)
Purchased, 2004
Primary Collection
Click on the links below to find out more:
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Sitterback to top
- (Michael) Derek Elworthy Jarman (1942-1994), Film-maker, painter and campaigner for homosexual rights. Sitter in 16 portraits.
Artistback to top
- Richard Hamilton (1922-2011), Painter. Artist of 2 portraits, Sitter in 12 portraits.
This portraitback to top
The portrait was taken by Hamilton shortly before Jarman's death when they met at Tate to celebrate the Gallery's recent acquisition of Jarman's Ataxia - Aids is Fun, the painting in the background. Hamilton later used computer manipulation to blur the image to approximate Jarman's view of the world, affected by a severe eye disorder connected with the later stages of AIDS.
Linked displays and exhibitionsback to top
- Contemporary Portraits (1 March 2012 - 22 April 2012)
- Portrait of an Artist (8 October 2007 - 19 May 2008)
Subjects & Themesback to top
Events of 1996back to top
Current affairsThe largest ever IRA bomb is detonated in Manchester causing the destruction of many buildings and over 200 injuries. Nobody died in the incident because a warning was given and the area evacuated. After the bombing much of Manchester was rebuild and in 1998 it won a successful bid to host the 2002 Commonwealth Games.
Prince Charles and Princess Diana finalise their divorce after four years of separation.
Art and scienceThe Spice Girls enjoy massive popular success with their first single Wannabe going straight to Number 1. The group are remembered as much for their sassy, outspoken 'girl power' attitude and their continuing subsequent celebrity as for their music.
Danny Boyle tells the story of a group of Edinburgh heroin addicts in his critically acclaimed film version of Irvine Welsh's novel Trainspotting.
InternationalThe First Chechnya War breaks out between Chechnya and Russia when Russian forces invade the country in support of Chechnyan opposition to the government. The invasion went badly with strong Chechnyan resistance and dissent in the Russian command. However, a truce was finally established after Russia seized the capital Grozny. More than 46,000 people died as a result of the conflict.
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Can you tell us more about this portrait? Spotted an error, information that is missing (a sitter's life dates, occupation or family relationships, or a date of portrait for example) or do you know anything that we don't know? If you have information to share please complete the form below.
If you require information from us, please use our Archive enquiry service. If you wish to license this image, please use our Rights and Images service.
Please note that we cannot provide valuations.
We digitise over 8,000 portraits a year and we cannot guarantee being able to digitise images that are not already scheduled.
Exhibitions and displays
- Life, Death and Memory
Until 4 February 2018


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State Police confirm today that a sleeping driver drifted off the roadway on Route 33 in Stafford, and sheared off a utility pole.
26-year-old Joshua Arnold received only minor injuries when his 2000 Isuzu left the roadway and crashed through the pole, before coming to rest in a field. Arnold was taken to Strong Hospital in Rochester with minor injuries.
The pole carried cable and phone lines, which were dropped in the road after the crash. Route 33 was shut down for hours, as Verizon crews had to be called to remove their wire from the roadway.


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You can check this page for more information about Diskology's veteran discounts and offers. You might also check out their homepage to see if they've posted any additional information about their military discounts. You can also subscribe to their email newsletter, as some stores will send special ...
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You can find information about Diskology's shipping policies here. You can always try their homepage to see if they have additional information posted about their shipping policies. They may occasionally post free shipping coupons and deals there too: diskology.com.
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Sorry! This item is unavailable.
But we found some similar items...
3 card pack Christmas cards - Silver City
3 card pack
A pack of 3 square Christmas cards featuring the words 'Merry Christmas' in red, green and silver repeated lots of times in different sizes and fonts.
The cards are made from 250gsm ultra smooth white cardstock and come with a 100gsm white envelope. They are blank inside for your own message.
Measurements: 12cm high by 12cm wide.
The cards will be despatched within two working days of receiving payment and will be sent using first class post. It comes wrapped in a cellophane packet to keep the card clean and is well packaged with stiff card to ensure it reaches you in perfect condition.
Please note that this item is handmade and therefore the exact size and placement of details may differ slightly from those shown in the photographs.
Shipping & delivery
This item will be posted to you by Say it within 3 days of receiving payment.
|Shipping destination
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Italy, Greece, Cyprus, Germany, France, Spain, Finland, Belgium, Portugal, Poland, Ireland, Sweden, Denmark, Netherlands, Austria, Latvia, Bulgaria, Czech Republic, Estonia, Hungary, Lithuania, Luxembourg, Malta, Romania, Slovakia, Slovenia
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Returns Policy
You have 14 days, from receipt, to notify the seller if you wish to cancel your order or exchange an item.
Unless faulty, the following types of items are non-refundable: items that are personalised, bespoke or made-to-order to your specific requirements; items which deteriorate quickly (e.g. food), personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken.


text: Maybe been covered before but I have just 'seriously' cleaned the alloys on my 2000 S3, only to find a week later they are covered in brake dust yet again. I don't know what make of pad are in as I have only had the car about six weeks, but I can't live with these pads now summer is arriving. I am thinking of painting the calipers and generally want to keep the whole brake area clean. Can anyone suggest any decent 'dust-free' pads (that will also stop the S3) that I can change them for, and also the best place to get them from. Thanks for any advice. H3MSY


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Some methods for reducing taxes are less known than others, and Canadians sometimes fail to deploy even the better-known ones because they wait too long to act, says John Natale, Assistant Vice-President, Tax & Retirement Services, Manulife Investments. The waning days of 2012 are a time to make sure that you don't lose out on any potential tax savings, he says, consider the following tips.
1. Realize a capital loss.
If you have any capital gains this year, or in the preceding three years, you may wish to realize a capital loss before the end of the calendar year to offset part or all of those gains and reduce your taxes[1]. Capital losses need to be deducted first against any capital gains in the current year. If you still have an excess on the loss side of the ledger, you can carry that back three years, or use it in any future year.
If you wait until next year (2013) to realize capital losses, and you want to carry the loss back to offset a capital gain from a previous tax year you would have to wait until you file your 2013 tax return, likely early 2014, to realize the tax savings. Furthermore, you could only carry back excess capital losses to 2010, and would lose the opportunity to apply the capital losses against any capital gains realized in 2009.
2. Make a spousal RRSP contribution.
For spouses in different tax brackets, there is an income-splitting strategy. A contribution to your spouse's Registered Retirement Savings Plan (also known as a spousal RRSP) provides a tax deduction for you. However, your spouse needs to wait three years after a contribution is made before making a withdrawal from a spousal RRSP to avoid it becoming taxable to you – the contributing spouse[2]. So by making the spousal RRSP contribution in calendar year 2012, you benefit from the deduction at your tax rate and your spouse can potentially withdraw the funds as early as 2015 and have the income taxed in their hands, at their tax rate. This could save you up to thousands of dollars in taxes depending on the spouses' respective tax rates. Waiting until the first two months of 2013 to make the spousal RRSP contribution means that the spouse will have to wait till 2016 before withdrawing that money without it being taxed at the contributing spouse's marginal tax rate.
3. If you're turning 71, fill up your RRSP room.
You can't add to your RRSP in the first 60 days of 2013, if you turn 71 in 2012. You only have until December 31 of this year before your RRSP closes. You still can contribute to a spousal RRSP until the last day of the year your spouse turns 71. If you don't have a spouse and you have RRSP room, waiting until January would mean losing the opportunity to contribute to your RRSP.
You don't have to deduct your RRSP contribution in the year you made it. Say you have $50,000 of room and you use it all up by making a lump sum contribution before closing your RRSP. You could claim the deduction in whatever year(s) are most beneficial to you. For example you could claim a $5,000 deduction each year for 10 years. This deduction will reduce your taxable income, and can help avoid or reduce the clawback of federal benefits such as Old Age Security.
4. Pay tax-deductible or tax-creditable expenses before year-end.
A variety of expenses can only be claimed as a tax deduction or tax credit on your tax return if the amount is paid by the end of the calendar year. If the intention is to pay a tax-deductible or tax-creditable expense early next year, consider paying the amount by the end of this year in order to get the benefit of the tax deduction or tax credit on this year's tax return.
Examples of tax-deductible expenses include interest, carrying charges, and employment related car expenses. Examples of tax-creditable expenses include medical expenditures, donations and children's' fitness and arts programs.
5. Make charitable donations.
If you include these donations on your 2012 tax return, the benefit is obvious – you receive the tax benefit a year earlier than if you had waited till your 2013 return. And consider the $200 threshold: On the first $200 donated, the federal tax credit is worth 15 per cent, and 29 per cent on the balance. Provincial tax credits also provide for higher credits after the first $200. You can pool your tax donations between spouses. You can also carry forward donations for up to five years, so you minimize the number of times you hit the $200 threshold. Keep in mind that if you donate non-registered mutual funds, segregated fund contracts or stocks in kind (i.e. transfer ownership to a charity) you will get a charitable receipt for the fair market value and the tax on any capital gain will be eliminated.
This commentary is for general information only and should not be considered investment or tax advice to any party. Individuals should seek the advice of professionals to ensure that any action taken with respect to this information is appropriate to their specific situation.
[1] You must keep the "superficial loss rules" in mind which limit your ability to claim a capital loss. Your loss may be denied if the same or identical asset is acquired within 30 days before and after the sale and is still held 30 days after the sale by you, your spouse or a corporation controlled by you.
[2] These are known as the spousal RRSP attribution rules. In order to avoid these attribution rules on a withdrawal from a spousal RRSP, there must not have been a contribution to any spousal RRSP in the year of withdrawal or the 2 previous years.


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Edit Article
wikiHow to Make Raspberry and Rose Lemonade
This is a recipe that spruces up your existing lemonade and turns into something quite special!
- 1.5 liters (0.4 US gal) of lemonade
- 250g of raspberries, fresh are best (clean them and remove stems); if you don't have fresh, use frozen
- 2 teaspoons of rose syrup
1Process or blend the raspberries until they are smooth. Make it as smooth as you like personally.
2Add the syrup and mix well.
3Pour the raspberry and rose mix into a jug (pitcher). It can also be poured into a lemonade bottle with a cap.
4Pour the lemonade in slowly and gently. If you pour it too fast, you'll cause the lemonade to froth up.
5Place the raspberry and rose lemonade into the refrigerator to chill for at least a half hour prior to serving.
6Add an ice cube or two to each glass before pouring the lemonade.
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Things You'll Need
- Blender or food processor
- Jug or pitcher; or lemonade bottle with cap
- Glasses for serving
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Categories: Lemonade Drinks | Rose Drinks
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JJ Hickson Is Going To China
It is, to be fair, impressive that falling behind 20-0 was not the Nets at their most woebegone last night. That honor belongs to the help defense on this JJ Hickson dunk, a true team effort:
Of course, no sooner do we find out who committed the two dumbest fouls of the season than JJ Hickson, at the end of the half last night against the Blazers, commits this travesty on Wes Matthews, behind halfcourt. Here now, the worst foul of the NBA season so far.
No one will blame you for not watching last night's Nuggets-Jazz game, as neither team has done much more than depress the hell out of their respective fan bases this year. But you are not allowed to go through life being unaware of this J.J. Hickson dunk, which turned poor Marvin Williams into a chalk outline.
J.J. Hickson didn't impress the Kings much this season, but he made his impact on Trail Blazers brass tonight with this thunderous slam on the Clippers' DeAndre Jordan. It was the kind of dunk Blake Griffin could appreciate, which made it convenient he was right there watching Hickson fly by. [ESPN]


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Edit Article
wikiHow to Make a Protractor
Three Methods:Printing a Protractor on PaperMaking a Pocket ProtractorDrawing a ProtractorCommunity Q&A
Protractors are a tool used in mathematics to measure angles in degrees. You might need a protractor to work on homework or make construction plans, so learning how to make your own can come in handy. You can make a protractor by printing from a template or folding a square of paper to always have one on hand.[1]
Printing a Protractor on Paper
1Get heavyweight paper or transparent paper. Find cardstock paper or another piece of heavyweight paper that will work for your printer. Heavyweight paper will make the protractor more durable. You can use transparent paper to make the protractor easier to use for measuring.[2]
- Check your printer's guidelines to make sure you can use transparent paper before you print.
2Download a protractor printable. Download the graphic of a protractor to use. You can find a protractor graphic to download by searching online.[3]
- Choose an image that is large for better quality. The clarity of your image will be determined by how large the graphic file is, look for something at least 540X620.
3Print the protractor graphic. Use your printer to print the graphic of the protractor. Preview the image before you print to make sure the entire protractor will be printed.
- Re-size the image to the desired size for your protractor. In general the straight edge of the protractor should be between 3 and 6 inches for best results.
4Cut the protractor out. Use scissors to cut the shape of the protractor out of the paper. Cut the center of the protractor out.
5Place the bottom edge of the cut out on one line of the angle. Align the bottom edge of the protractor with one of the rays of the angle you would like to measure. Where the second ray of the angle crosses the curved section of the protractor is the measurement of the angle.
Making a Pocket Protractor
1Cut a sheet of paper into a square. Get an 8 ½"x 11" sheet of paper to cut into a square.
- Use a ruler to measure 8 ½ inches down the 11 inch side and make a mark at that point.
- Use the ruler to draw a straight line across the paper at the mark you made.
- Cut the paper on this line to end up with a piece of paper that is 8 ½ x 8 ½ inch square.
2Fold the paper in half. Fold the left side of the paper over to the right side to make a crease in the middle of the paper. Then, unfold the piece of paper.
- Align the edges of the paper exactly to make sure your fold is directly in the center of the paper.
- The accuracy of your angles depends on your folds being crisp and exact.
3Fold the upper right corner into a triangle. Take the upper right corner and fold it down towards a low point on the crease you made in the middle of the paper. Fold the corner down so that it meets the crease in the middle of the paper.
- The corner will be approximately ⅔ of the way down the center crease you made when you folded the paper in half
- This will form a triangle on the paper that has a 30° angle, a 60° angle, and a 90° angle.
- You will fold the entire top edge of the paper down to create a new tip in the upper left hand of the paper.
4Fold the bottom right corner up to form a second triangle. Take the bottom right corner up towards the top edge of the first triangle. Fold until the right edge of the paper lines up with the creased edge of the first triangle.
- You will end up with a second 30°,60°,90° triangle.
5Fold the bottom left corner up. Take the bottom left corner and fold it up until the left side of the paper meets the edge of the first triangle the was originally the top edge of the paper. The two edges should line up together.
- Tuck the corner under the second 30°, 60°, 90° triangle you folded.
6Label the angles on your protractor. The side of each different triangle makes a different angle that you should label. Put your paper down with the longest side pointing up.[4]
- There are two angles at the top of your protractor. The left side is a 15° angle, and the right side is a 30° angle.
- The left corner of your protractor has two angles. The angle on top is a 45° angle, and the angle on the bottom is a 30° angle.
- The right corner of your protractor is a 60° angle.
- The angle made on the right side of your protractor where a line goes through the protractor is a 90° angle.
- The bottom left corner contains a 45° angle on the right and a 30° angle on the left
7Use your pocket protractor. You can use your pocket protractor to measure angles on different shapes by matching the angles on the shape to the angles on your protractor.
- Estimate the degrees of angles that fall between the measurements for your protractor.
- You can divide the angles further into smaller triangles by folding the triangles in half.
8Place your protractor on the angle you are trying to measure. Rotate the protractor to align the angles of the triangles on your paper with the angle you are measuring.
- Determine the angle you are measuring by matching it to the angles on the paper protractor.
Drawing a Protractor
1Use a ruler to draw a horizontal line. Draw a line on a piece of paper that is 5 inches long. You can also use the bottom edge of your paper as the bottom edge of the protractor to skip this step.
- Make a mark in the exact center of your line at 2.5 inches from the ends of the line.
2Draw a half circle with a compass. Use a compass to connect the edges of your line in a half circle arc.
- Set your compass to create a circle with a diameter of 5 inches.
- Draw a half circle connecting the ends of your horizontal line or centered along the bottom edge of the paper.
3Fold a square piece of paper to create angle measurements. Using a paper square fold the square exactly in half lengthwise and along each diagonal.
- A piece of origami paper makes a good square to use.
- You can cut a perfect square by folding the top edge of a piece of printer paper to align with a side edge. Draw a line across the bottom where the paper crosses and cut off the bottom section of the paper.
- Use the fully opened square to trace a 90º angle on your protractor. Place the bottom of the square along the bottom of the protractor. Align the edge of the square with the center of the line and trace along the edge of the square.
4Mark the angles on your protractor. The square folded in half creates a 45 degree angle. Place the folded triangle along the bottom edge of your protractor and mark a line on the curved arc where the triangle crosses the arc. label the line 45 degrees.
- Fold a triangle with one edge from the upper left corner of the paper to the bottom center of the paper. This will create a 60º angle. Create the same fold from the right side to create a 120º angle. Mark these angles on your protractor. Make each fold on both sides of the triangle to create the complimentary angles for both sides of the protractor.
- Fold a new triangle with the inner edge of the triangle extended from the upper left corner down to the center of the paper. The corner of the triangle will be slightly to the right of the center of the paper and an imaginary line extends from the corner of the paper to the bottom center of the paper. This will create a 75º and 105º angle.
- Flip the folded paper over and place the edge of the paper on the 90 degree angle of your protractor. The edge of the triangle now marks a 15 and 165º angle
5Cut out your protractor. Use scissors to carefully cut out the half circle of your protractor.
- Cut a small "D" shape from the center of the protractor to see the lines of angles you would like to measure.
6Measure angles. Place the bottom edge of the protractor along one edge of the angle you are measuring. Align the other leg of the angle with curved arc of the protractor. Note where the ray crosses the arc of the protractor to determine the angle you are measuring.
- Place the vertex of the angle where you marked the center of the bottom of the protractor.
Community Q&A
Are there any ways to do it without a real protractor?Yes. See Method 2 above.
Unanswered Questions
Can you copy it onto tracing paper?
Ask a Question
200 characters leftSubmit
- Wait until the ink dries completely on the transparent paper before cutting the protractor out. You might smudge the ink if you try cutting too soon.
- Make your folds sharp and precise on the pocket protractor to get accurate angles.
- You can make larger angles on the pocket protractor by opening the folds up to double the angle.
- Tape the triangles you folded in the center to ensure the pocket protractor holds its shape.
Things You'll Need
Printed Protractor
- Heavyweight or transparent paper
- Printer
- Scissors
Pocket Protractor
- Paper
- Pen or marker
- Ruler
- Scissors
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Categories: Mathematics
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Русский: сделать транспортир
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