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International Journal of Alzheimer's Disease
Volume 2011 (2011), Article ID 690121, 6 pages
Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
1Department of Neuropathology, Institute of Pathology, University of Greifswald, 17487 Greifswald, Germany
2Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, 17487 Greifswald, Germany
Received 26 January 2011; Accepted 4 April 2011
Academic Editor: Brian J. Balin
Copyright © 2011 Anja Brenn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Neurovascular dysfunction is an important component of Alzheimer's disease, leading to reduced clearance across the blood-brain barrier and accumulation of neurotoxic β-amyloid (Aβ) peptides in the brain. It has been shown that the ABC transport protein P-glycoprotein (P-gp, ABCB1) is involved in the export of Aβ from the brain into the blood. To determine whether Aβ influences the expression of key Aβ transporters, we studied the effects of 1-day subcutaneous Aβ1-40 and Aβ1-42 administration via Alzet mini-osmotic pumps on P-gp, BCRP, LRP1, and RAGE expression in the brain of 90-day-old male FVB mice. Our results demonstrate significantly reduced P-gp, LRP1, and RAGE mRNA expression in mice treated with Aβ1-42 compared to controls, while BCRP expression was not affected. The expression of the four proteins was unchanged in mice treated with Aβ1-40 or reverse-sequence peptides. These findings indicate that, in addition to the age-related decrease of P-gp expression, Aβ1-42 itself downregulates the expression of P-gp and other Aβ-transporters, which could exacerbate the intracerebral accumulation of Aβ and thereby accelerate neurodegeneration in Alzheimer's disease and cerebral β-amyloid angiopathy.
1. Introduction
Burgeoning evidence implicates cerebrovascular dysfunction in the cognitive decline and neurodegeneration that characterize Alzheimer's disease (AD) [1, 2]. Impaired clearance of β-amyloid (Aβ) across the blood-brain barrier (BBB) and the senescence of the cerebrovascular system are thought to initiate processes that contribute to neurodegeneration [1, 3]. The transport of Aβ across the BBB comprises a two-step process involving transport through the abluminal (brain side) and then through the luminal (blood side) plasma membranes of the endothelial cells. The low-density lipoprotein receptor-related protein-1 (LRP1) mediates the incorporation of brain-derived Aβ peptides into the endothelial cells at the abluminal membrane [4, 5]. On the other hand, the receptor for advanced glycation end products (RAGE) is considered to be a major influx transporter of peripherally derived (blood-borne) Aβ into the endothelial cells of the cerebral vasculature [6, 7]. The ABC transporter P-glycoprotein (P-gp, ABCB1) is highly expressed at the luminal side of the endothelial cells that form the BBB, and may play a key role in the transport of Aβ peptides (either brain or blood derived) into the blood [8]. In vitro and in vivo experiments have shown that P-gp is an active transport protein for Aβ1-40 and Aβ1-42 [9–14]. These observations suggest that diminished P-gp expression due to increasing age, genetic, or environmental factors may lead to impaired Aβ clearance, followed by the accelerated accumulation of intracerebral Aβ and eventually the development of AD.
An autopsy study of nondemented elderly humans found that vessels with Aβ accumulation within their walls (cerebral amyloid angiopathy, CAA) showed little or no endothelial P-gp expression whereas unaffected capillaries had high P-gp expression, leading to the hypothesis that Aβ leads to a downregulation of P-gp expression whereas P-gp might be upregulated in the endothelium of capillaries lacking Aβ accumulation in an attempt to compensate for the loss of P-gp in amyloid-bearing vessels [11]. Thus, the aim of the present study is to investigate the effect of Aβ administration on the expression of P-gp and other Aβ transporters in endothelial cells of the cerebral vasculature.
2. Material and Methods
2.1. Laboratory Animals
90 day-old male FVB wildtype mice (purchased from Taconic, Hudson, NY, USA) weighing approximately 25 g were used. Animal care and experimental conditions were conducted in compliance with protocols approved by the local Animal Care and Use Committee.
2.2. Preparation and Subcutaneous Implantation of ALZET Mini-Osmotic Pumps
10–12 animals per group were used for the systemic administration of Aβ1-40 (DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV), Aβ1-42 (DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA), or reverse Aβ40-1 (VVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD) or reverse Aβ42-1 (AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD). All peptides were purchased from AnaSpec Inc. (Fremont, CA, USA).
1 mg of each peptide was dissolved in 4 μL DMSO and mixed with 2 mL isotonic NaCl solution, yielding a final Aβ concentration of 0.5 μg/μL. 200 μL (=100 μg peptide) of this solution were used to fill the Alzet mini-osmotic pumps. 200 μL of isotonic NaCl solution served as vehicle control.
ALZET mini-osmotic pumps (model 2001D; DURECT Corporation, Cupertino, USA) were implanted subcutaneously using a midscapular incision. Pumps delivered synthetic, human-type sequence Aβ1-40, Aβ1-42, reverse Aβ40-1, Aβ42-1 peptide, or isotonic NaCl solution, respectively. After a 2-hour start-up transient, the pumps infuse at a constant pumping rate of 8 μLh-1.
After 26 h mice were sacrificed by cervical dislocation and the brains were immediately removed. One hemisphere was shock-frozen in liquid nitrogen and stored at −80°C until use. The other hemisphere was fixed with neutral-buffered 4.5% formalin and was embedded in paraffin.
2.3. Real-Time PCR Analyses
For real-time PCR analysis, RNA was isolated from deep-frozen brain tissue using the RNeasy Mini kit form Qiagen according to the manufacturer's instructions (Qiagen, Hilden, Germany). Reverse transcription of total-RNA was performed by the TaqMan reverse transcription kit using random hexamer primers (Applied Biosystems, Darmstadt, Germany). Quantitation of RNA (cDNA) levels for Abcb1a, Abcg2 (Mm00496364_m1), LRP1 (Mm00464608_m1), as well as RAGE (Mm00545815_m1) and 18SrRNA (part # 4319413E) for normalization was performed by real-time PCR on a 7900HT TaqMan system (Applied Biosystems) using predeveloped TaqMan assays (Assays on Demand, Applied Biosystems). All PCR reactions were performed in 10 μL reactions using a PCR master mix (2x concentrated) containing 45 mmol/L Tris-HCl (pH 8.4), 115 mmol/L KCl, 7 mmol/L MgCl2, 460-μmol/L dNTPs, 9% glycerol, 2.3% ROX reference dye (Invitrogen, Paisley, Scotland) and 0.035 U/mL Platinum Taq DNA polymerase (Invitrogen). Thermal cycler conditions were as follows: (50°C, 2 min; 95°C, 10 min followed by 40 cycles of 95°C, 15 s and 60°C, 1 min).
Expression analysis was performed by the comparative ΔΔCt-method using the expression of 18SrRNA as reference gene.
2.4. Immunohistochemistry
For immunohistochemistry, brain tissues were fixed in neutral-buffered, isotonic 4.5% formalin and embedded in paraffin. 1 μm-thick tissue sections were cut, mounted on slides and dried overnight at 60°C. For staining, the biotin-streptavidin immunoperoxidase method with polymer detection system-HRP was used. Automated immunohistochemical staining was performed using the BOND-MAX (Leica) staining systems using pre-diluted antibodies to murine P-gp (clone C219, dilution 1 : 25, pH 9.0, Enzo Life Sciences) and BCRP (clone BxP53, dilution 1 : 50, pH 9.0, Enzo Life Sciences).
Negative controls for each treatment were processed without primary antibody.
2.5. Image Acquisition and Analysis
Digital images were captured using the Zeiss Mirax Scan Desk slide scanner (Carl Zeiss MicroImaging GmbH, Göttingen, Germany; Plan-Apochromat 20x/0.8, pixel resolution: 0.37 μm). To quantitate P-gp expression, image analysis algorithms were developed using ImageJ (version 1.43 q, Research Services Branch, National Institute of Mental Health/National Institutes of Health, Bethesda, MD, USA; http://rsb.info.nih.gov/ij/), which allowed the identification and analysis of immunolabeled cerebral capillaries in digital images. The amount of P-gp-specific labelling in each animal was determined in ten high-power fields (x40) of the brain cortex, the staining intensity for cortical P-gp of a single animal was the mean of all measurements.
2.6. Statistical Analysis
Statistical analysis was performed using Microsoft Excel and GraphPad Prism 5.01 (GraphPad, San Diego, USA) software using the ΔCt expression values. The statistical tests employed are indicated in the respective sections/figure legends. If the data are represented as boxplots, the whiskers indicate the 10th and 90th percentiles.
3. Results
First, mRNA expression for P-gp (Abcb1a), BCRP (Abcg2), LRP1, and RAGE was measured by real-time PCR in mice treated with Aβ1-42, vehicle control, or the reverse protein (Aβ42-1) for 24 h using subcutaneously transplanted ALZET pumps. Transporter expression was detected in all samples for Abcb1a and Abcb2 while analysis of LRP1, and RAGE failed in one Aβ1-42-treated mouse. Significant changes in the expression of Abcb1a, LRP1 and RAGE were detected in mice given Aβ1-42. While transporter expression was not significantly altered between the control perfusion group and the mice treated with equal amounts of the reverse Aβ protein, animals treated with Aβ1-42 had significantly reduced Abcb1a levels in brain (reduced by 63 ± 24% [mean ± SD]) compared to mice given the vehicle control, and by 54 ± 30% compared to mice given the reverse-sequence protein), LRP1 levels (reduced by 57 ± 17%) compared to vehicle controls and by 60 ± 17% compared to the reverse protein controls); and RAGE levels (reduced by 65 ± 15% compared to the reverse protein controls, no significant difference relative to vehicle controls Figures 1(a), 1(c), and 1(d)). In contrast, expression of Abcg2 remained unchanged in these samples (Figure 1(b)).
In a second experiment, mice were treated with Aβ1-40 in a similar manner. Here, no significant changes were detected in any of the four proteins; however, the expression of RAGE tended to be lower compared to the vehicle control samples (Figures 2(a)–2(d)).
At the protein level, P-gp and BCRP were detectable in endothelial cells of brain vessels in all animals using immunohistochemistry (Figures 3(a) and 3(b)). However, quantitatively no changes of P-gp or BCRP could be detected after administration of Aβ1-42 or Aβ1-40 in comparison to the reverse Aβ peptides or vehicle control, respectively (data not shown).
4. Discussion
There is growing evidence that an alteration of the transport of Aβ peptides across the BBB plays a crucial role in the pathogenesis of AD and CAA. In addition to other transport proteins such as LRP1 and RAGE, the multidrug resistance transport protein P-gp is known to eliminate Aβ1-40 and Aβ1-42 from the brain [12–14]. In nondemented elderly humans, Aβ deposition is inversely correlated with brain capillary P-gp expression [10]. Interestingly, investigations of the correlation between CAA and P-gp expression indicate a loss of P-gp in vessels with abundant cerebrovascular Aβ accumulation. In this study, CAA was primarily found in small arteries, but in the advanced stages of CAA, the capillaries also were affected [11], leading to the question of how Aβ itself affects P-gp expression in the endothelial cells that are a key component of the BBB.
The present study found that peripherally administered Aβ1-42 leads to a decrease of P-gp expression in vivo in mouse brains at the mRNA level. This finding is in concordance with the results of Hartz et al., who reported that P-gp expression and transport activity are compromised in brain capillaries isolated from hAPP transgenic mice that exhibit accumulation of human-type Aβ within the brain [14]. Thus, it can be hypothesized that the compromising effect of Aβ on P-gp expression leads to a further increase of Aβ accumulation, thus initiating a vicious circle that exacerbates the progression of the disease.
LRP1 is localized at the brain-side membrane of capillaries; as a receptor for Aβ, LRP1 mediates the transport of the peptide from the brain into the endothelial cells. LRP1 expression was reported to be reduced during normal aging in animals and in AD patients associated with accumulation of Aβ1-40 and Aβ1-42 within the cerebral vessels [4, 15, 16]. Our results revealed significantly reduced levels of LRP1 mRNA in mice treated with Aβ1-42, confirming the lowering effect of Aβ on LRP1 expression. However, 12-week-old hAPP mice revealed slightly increased LRP1 expression whereas RAGE was unchanged, suggesting the critical limiting step in Aβ brain clearance could be P-gp-mediated Aβ transport across the luminal endothelial membrane into the blood [14].
RAGE is normally expressed at the luminal side of the endothelial cells, and mediates the transport of Aβ1-40 and Aβ1-42 from blood into the endothelium [6]. In AD and AD models, cerebrovascular RAGE was shown to be increased [17]. Our results show that mRNA levels were significantly reduced in mice treated with Aβ1-42 in comparison to the reverse-sequence peptide. Relative to the vehicle control, RAGE mRNA expression showed a trend to be reduced by Aβ1-42, but did not reach statistical significance. However, our findings are in concordance with the observation that the expression of RAGE in Brown-Norway/Fischer rats decreases in early stages of Aβ accumulation and increases with advanced age [18]. This suggests that an increase of RAGE expression plays a role in the later stages but not in the initiation of AD.
Our results show that Aβ1-42, but not Aβ1-40, inhibits P-gp, LRP1 and RAGE expression at the BBB. Under physiological conditions, the ratio of Aβ1-42 to Aβ1-40 in the brain is about 1 : 10 [19]. Thus, the amount of Aβ1-40 in our pumps might have been too low to achieve sufficient effects on P-gp expression at the capillary endothelial cells. However, since the aggregative ability and the neurotoxicity of Aβ1-42 are much greater than those of Aβ1-40, Aβ1-42 plays a more important role in the pathogenesis of AD [19, 20]. In this regard, Aβ1-42 was reported to induce free radical-related oxidative stress and neurodegeneration in AD brains [21]. Interestingly, in contrast to Aβ1-40, the concentration of free Aβ1-42 in cerebrospinal fluid is lower in patients with AD, suggesting that Aβ1-42 might be preferentially incorporated into growing plaques [20].
In our study, the decrease of P-gp expression was observed at the mRNA level but not at the protein level using immunohistochemistry. This might be due to the short period during which Aβ is present within the blood, leading to acute effects of Aβ on transcription processes that were not reflected in changes of protein expression within this timeframe. Possibly, a longer treatment period is necessary to address this question.
Like P-gp, BCRP is localized at the luminal site of vascular endothelial cells and contributes to the integrity of the blood brain barrier (BBB), thus protecting the brain parenchyma from the damaging effects of xenobiotics [22]. P-gp and BCRP share extensive similarities regarding their substrate specificity, and the list of substrates of BCRP has been steadily expanding since its discovery [23]. Using a human brain endothelial cell line (hCMEC/D3) Aβ1-40 has been shown to be a substrate of BCRP [24]. Xiong et al. reported that BCRP mediates the transport of Aβ in BCRP-overexpressing cell lines, and that Aβ accumulates in the brains of BCRP-knockout mice. On the other hand, BCRP expression was increased in brain tissue of AD cases [25]. However, in the present study we found BCRP expression to be unchanged by circulating Aβ. This is in agreement with the findings on young hAPP mice, where no evidence was found for BCRP-mediated Aβ transport in brain capillaries [14]. Thus, it can be hypothesised that BCRP, like RAGE, might not be involved in the early stages of AD, but rather may play a role in more advanced stages of the disease.
5. Conclusions
These findings lend further support for the involvement of the ABC transport protein P-gp in the transport of Aβ across the BBB. Specifically, circulating Aβ itself lowers P-gp expression at the BBB, leading to a circulus vitiosus that triggers further Aβ accumulation. The activity of P-gp is well known to be modulated pharmacologically by a range of commonly used drugs [26–28]. Thus, restoring P-gp function could be a novel therapeutic strategy to protect the brain from Aβ accumulation, and thus could be a tool to prevent and/or slow the progression of CNS disorders such as Alzheimer's disease.
The authors gratefully acknowledge helpful comments by Lary Walker (Emory University) and the excellent technical help of Cathrin Müller and Katrin Sokolowski, Department of Pathology, as well as of Tina Sonnenberger, Department of Pharmacology. The paper was supported by FP7-REGPOT-20081-1 CSA Project ImpactG; Grant agreement no. 229750.
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Lately, some subjects like the veil, polygamy, and divorce in Islam have become objects of discussion and dispute upon which the mass media, especially the Western media, shed light. What are the veil, polygamy, and divorce in Islam? In this book you will find:
Islam... What is divorce for? What is more than one wife for?
©2010-2013 A. K. John Alias Al-Dayrani (P)2013 A. K. John Alias Al-Dayrani
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|Home > Music Genre > Sound-Alikes Music > Kanye West > Track Summary >
Track Summary
Music Track Title: Devil Instrumental
Catalog ID: 511660 ISRC: US5UL1202335
Description: Hip Hop Kanye West, lil wayne, rick ross and cool synth elements turning more positive at end . Sized perfectly for Open, Life On Street, Crime Drama, Medical Investigation, Young Interns. Ad, Jeans, Levis, Axe, Instrumental, Aggressive Urban Groove, tugs, dirty south. T Pain,
Social Media Link: https://www.audiosparx.com/sa/archive/Soundalikes/Kanye-West-Soundalikes/Devil-Instrumental/511660
Artist or Group: Eddie Caldwell
Keywords: Club Banger Ala, Shakira, Sean Paul, Shaggy, Black-Eyed Peas. Perfect for Film/TV About Youth Culture, Parties, Clubs, Dance, Girls, Instrumental, Jay Z,
Music Genre > Sub-genre
Sound-Alikes Music
Kanye West Sound-Alike Music
Extended Properties
Duration: 3:15 Tempo: Medium BPM: 110
Arrangement: Band / Ensemble
Instruments: Synthesizer, Electronics, Synthesized Vocals
Vocal Mix: Instrumental
Album: IFunk
Moods: Abstract, Cool, Dancing, Dramatic, Driving, Dynamic, Funky, Groovy, Hypnotic, Moody, Motivational, Moving, Positive, Powerful, Pulsating, Rhythmic, Sexy, Street-Smart, Vengeful, Vibrant
Styles: Action Thriller, Afro-American, Club / Bar / Lounge, Comedy / Dark Humor, Dance / Night Club, Drama / 30-Something, Entertainment, Fashion Show, Law & Crime, Section / Credits
Extended Keywords: A sensational club anthem, akon, murder, women, sleazy, drugs, gangs, Fear Nervous Stress High Power Energy Energizing Tense Tension Bad Guys Crooks Evasion Urban Themes Young Adults Party Scene Clubbing Commercials Advertising
Aggressive, Edgy and Slammin Hard Techno-Rock. synth line with a driving groove. Nice Open "Holes" in the form. Sports, commercials, infomercials, film, TV, webisodes, internet, powerful, upbeat underground activity and industrial energy.
techno groove with a driven melody. Bass synth, arpeggios and electronic drums makes this track suitable for any kind of music game. Has a similar sound to tracks from the popular Playstation game WipEout but more laid back. Instrumental, Dance Music, Techno, lady gaga, madonna, britney spears, rhianna, black eye peas, cell phones. automobiles, airplanes, clubs rave, models, award shows Top Model sass sassy flirty flirtatious catwalk high fashion bling ghetto urban pimp city Afro


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Has the background color been changed?
It seems to be a very pale tan now - I like it!
Seems softer and easier on my eyes.
Welcome to the Quilting Board!
Has the background color been changed?
It seems to be a very pale tan now - I like it!
Seems softer and easier on my eyes.
It's not any different on my monitor.
Definitely better than the stark white that they started with, or else my eyes are adjusting to it.
I believe you are right. it is not so startling white. sorta off white.
i have two computers here at the house. i use two at the office. each one has a different make and model monitor.
the board looks very different on each monitor.
I Quilt, I Nap, I Quilt Some More ... Aaaaah, The Good Life!
I also have an eddres you can use if you need to contact me with questions or suggestions that relate to our community: [email protected]
Well is it just me or did the whole format change while i was away at work? The board has a new look, to me anyway
The Marines i have seen around the world have the cleanest bodies, the filthiest minds, the highest morle,and the lowest morals of any group of animales i have ever seen. Thank God for United States Marine Corps! Eleanor Roosevelt First Lady 1945
i put the brightness down on my monitor too. helped.
Things seem a little different around here and yes it appears the background has softened a bit. I like it.
Experience is simply the name we give our mistakes.


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The latest addition to our Reviews Section is a piece by Erica Mena on Anja Utler's engulf—enkindle, which is translated by Kurt Beals and came out in December from the admirable Burning Deck.
The best source for info on German poet Anja Utler seems to be this site (which, for those of you into poetry of the experimental flavor, looks pretty awesome on the whole), which has this to say:
Her first volume of poetry, asfsagen, was published in 1999, followed by münden – entzügeln (engulf – enkindle) in 2004. The year before, she received her doctorate for her thesis on women Russian modernist poets.
That same year she was awarded the Leonce-und-Lena-Preis, an award devoted to outstanding younger poets. That award jury described her poetry as "sensual sound constructions, on paper as in recitation, without being pure sound-poetry. Rather, they are language games of psychological world perception, that out of the substance of their words create shafts of illumination through which our curiosity, but also our bafflement in the exploration of language, feel their way."
Erica Mena is a member of the Best Translated Book Award poetry committee (quick interjection: engulf—enkindle isn't eligible for this year's award, but come BTBA 2012 . . . ), who is also a poet, translator, and noted screeder.
But today, Erica is gushing rather than screeding . . . Based on the first paragraph alone, I think Erica kinda sorta likes this collection . . . (And be sure to scroll to the bottom to hear a recording Erica did of one of the poems):
engulf — enkindle is a stunning book of poetry. It literally stunned me into absolute submission; it is the book of poetry I'd been wanting to read for years. It's a small volume, and I read it in one sitting, faster than I normally read poetry, because I couldn't slow down. The language sunk its hooks into me and pulled me through the book, like rafting down rapids. If some of this sounds violent, that's no mistake – the book is full of sensual violence, done to the body of language and the body in the poem.
want now: you – drive into me
want to push to the edge, hang, you
haul all my: shale, scrape
it off from: the head, from the shoulders
to rootstock throat gravel: you split me
give me – as if severed – sharp
countours – fangs wolffian ridge
questions too – will i? –
i – take you to me
balances I
Click here for the full review.
engulf — enkindle is a stunning book of poetry. It literally stunned me into absolute submission; it is the book of poetry I'd been wanting to read for years. It's a small volume, and I read it in one sitting, faster than I normally read poetry, because I couldn't slow down. The language sunk its hooks into me and pulled me through the book, like rafting down rapids. If some of this sounds violent, that's no mistake – the book is full of sensual violence, done to the body of language and the body in the poem.
want now: you – drive into me
want to push to the edge, hang, you
haul all my: shale, scrape
it off from: the head, from the shoulders
to rootstock throat gravel: you split me
give me – as if severed – sharp
countours – fangs wolffian ridge
questions too – will i? –
i – take you to me
balances I
The stacatto lines, broken by strange punctuation, expose themselves as duplicitious; the punctuation is superfluous, and yet it's not. It's a violation of the line, of the rules of grammar, but it forces a rhythm on the almost unwilling reader. It's pleasurable and distressing simultaneously, mimetic of the poems. The I in the poem submits to the violence of the you, while exerting her own controlled violence over the reader, and the poem and ultimately her poetic body.
Like most "experimental" texts this work demands more of its reader, a different set of tools and strategies. It is a text that has been splayed wide open, disgorging multiple readings. This extract from the second poem could be read as describing what the poetry itself is doing:
– percieve: just at the opencuts: set free
furrow – to stand, sense, to drift now am: pitching to you
through the: fissures [. . .]
[The bracketed ellipsis is mine.] Pay attention to the slippery shifts of meaning across and through the punctuation, the way caesura is inserted into the lines and creates tension with the phrases that follow the colons. Feel the tension that is created by the speeding up and slowing down of the lines, the gaps in meaning and thwarted grammatical expectations (the missing subject for "am" for example).
This is poetry that demands several readings, at least one of which must be aloud. When I teach poetry, I always ask that the students read the poems out loud, as well as to themselves, and if I suspect they have not done it we do it together. Great poetry creates sonic space on the page, and visual space in the voice, and the movement between these opens up new meanings. Traditionally, this happens behind the semantic content of the poem, but Beals's rendering of Utler's poetry prioritizes its lyric qualities. In engulf – enkindle, the poems hinge on sound and silence, on rhythm and breaking, with meaning following. Try listening to this without reading along, and see what kind of difference it makes.1
finally, startled from sleep, find:
the larynx deseeded is
hollowed: hands palpate,
it: fumbling, feathered, from
ribcage entwine themselves
deeper into the: reed swallow: light,
gurgling, darkly well, dimly
they: keel towards hulls towards hollows
weave: cavities, gorges of
stalks of fingers of (..)
so to speak: towards the bittern – neting place,
in the singing reed so it's called – grow
entangled as – flotsam and jetsam – stitched
up to the: glottis rustling
almost trembling i hear you again: say
song you say song – what is: song
Kurt Beals is a genius. I can't imagine how these translations could have come to be otherwise. He may have been working at an advantage; Germanic languages share many rhythm and sound paterns, two of the most impressive features of this translation. Still, the strangeness of these poems, which demand so much of the reader, must have demaned even more of Beals. To create this kind of complexity in translation is nothing short of stunning, an acheivment compounded by the shifting registers and pacing of the language.
This is an uncompromising work of brilliance on both Utler and Beals' parts. It's sharp and sexy, challenging and riviting and absolutely relentless. This is the poetry I've been waiting my whole life for.
1 Here's a recording Erica made of "Utler IX":
Mario Benedetti (1920-2009), Uruguay's most beloved writer, was a man who loved to bend the rules. He gave his haikus as many syllables as fit his mood, and wrote a play divided into sections instead of acts. In his country,. . .
Kim Kyung Ju's I Am a Season That Does Not Exist in the World, translated from the Korean by Jake Levine, is a wonderful absurdist poetry collection. It's a mix of verse and prose poems, or even poems in the. . .
Yuri Herrera is overwhelming in the way that he sucks readers into his worlds, transporting them to a borderland that is at once mythical in its construction and powerfully recognizable as a reflection of its modern-day counterpart. Kingdom Cons, originally. . .
Imagine reading a work that suddenly and very accurately calls out you, the reader, for not providing your full attention to the act of reading. Imagine how embarrassing it is when you, the reader, believe that you are engrossed in. . .
Leila Guerriero's A Simple Story: The Last Malambo chronicles the unique ferocity of a national dance competition in Argentina. The dance, called the malambo, pushes the physical and mental limits of male competitors striving to become champions of not only. . .
Aira continues to surprise and delight in his latest release from New Directions, which collects two novellas: the first, The Little Buddhist Monk, a fairly recent work from 2005, and The Proof, an earlier work from 1989. There are a. . .
The narrator of Peter Stamm's first novel, Agnes, originally published in 1998 and now available in the U.S. in an able translation by Michael Hofmann, is a young Swiss writer who has come to Chicago to research a book on. . .


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Teenager and budding gymnast Erin O'Hara is determined that nothing - not even a condition which threatened her life - will hold her back.
Erin O'Hara was just eleven years old when she started to experience severe abdominal pains.
She had been perfectly healthy before this brush with illness and led an active life, living for her time with Shooting Starz gymnastics in Campsie.
But quickly she went from being a very happy and healthy young girl to a child who was painfully thin and a shadow of her former self.
Her mother, Geraldine explained: "Very quickly it was suspected that Erin had a problem with her bowel or colon but because the service isn't great in Northern Ireland, we were forced to wait 13 weeks until she could have a colonoscopy."
By that stage Erin had dropped to just over three stone in weight. "There was no option for us but to wait," Geraldine said. "There was no private option, no way to move up the list. Erin had already been classed as an emergency."
Finally Erin underwent the diagnostic test and was diagnosed with Ulcerative Colitis. "It was the kind that didn't respond to drug therapy and we were told very early on that I would need surgery."
With Erin becoming sicker all the time, and continuing to lose weight, there was no time to waste when booking her surgery - but the procedure itself would be radical and life changing.
"My full colon was removed, and part of my rectum. That will allow for a reversal in the future if I ever feel I need one. But that would be a big decision and comes with its own risks."
As a result of her surgery Erin was left with a colostomy bag - a pouch which collects her body's waste products throughout the day through an opening (stoma) in her abdomen and needs changed regularly.
And during the surgery to remove her ulcerated colon Erin and her family learned that things could have been much, much worse.
"My bowel perforated in the surgeon's hand," Erin said.
"If that had happened outside of those settings, we would have been looking at a very different outcome."
While many young girls may well have struggled to cope with such a radical change to their body, Erin remained upbeat. "It didn't bother me - to have the bag - because I had been so sick beforehandand this was making me better. I focused on the positive."
Her mum said it was wonderful to watch her daughter start to gain weight and regain her energy.
"She was so malnourished that even though she was 11 she was as small as an eight year old. It has taken a while for her catch up."
One of the driving factors in Erin's recovery and ongoing positive attitude has been her love for gymnastics. "When I was really sick and when I was going for surgery I just kept asking if I would be able to do gymnastics again. That was my main concern."
Her fellow gymnasts and teachers from Shooting Starz Gymnastics came to visit Erin in hospital and when she was able to return they devised a programme to help bring her back to fitness.
"I was worried that the stoma would affect my ability to do gymnastics, but the only thing I can't do because of it are the high bars. I give everything else a go."
Erin is determined that the stoma, her colostomy bag and her colitis will not hold her back in life. She is just starting fifth year at Thornhill College and while she has now decided to speak openly about her condition, she said that many of her friends would not even know she has a stoma bag.
"It makes a bit of noise sometimes," she said, "And if I am nervous it can be worse - but no one has ever told me they could hear it and I think it sounds a lot like a tummy rumbling."
It was earlier this summer that Erin truly embraced her new body however. When model Bethany Townsend posted a picture of her in a bikini, showing off her colostomy bag it prompted people living with colitis and Crohns to start uploading their own 'Belly Selfies' to Facebook.
Erin soon made the decision to share her own picture. "I didn't know what to expect. When I decided to wear a bikini on holiday I didn't know if people would stare, or react in a negative way.
"And when I posted the picture online I wasn't sure how people would react but the reaction has been brilliant.
"People have been really supportive - they've told me I'm brave. I just want to raise awareness of Inflammatory Bowel Disease and prove that it doesn't have to change your life for the worse."


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After eight consecutive quarters of comparable-store sales growth, Stein Mart (Jacksonville, Fla.) has told shareholders that the company plans to continue growing, according to the Jacksonville Daily Record.
Stein Mart, which operated 264 stores in 29 states at the end of fiscal 2013, plans to open 10 new stores this year, while it relocates six existing stores and closes two. The plan will constitute the company's largest store growth since 2007.
President and coo D. Hunt Hawkins said Stein Mart has identified 125 possible locations for new stores, mainly in existing markets, although the company is also looking at new markets, including California.


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3 Lots available. Each being offered at $8,900.00 Lots 122, 123 and Lot 125. Wooded and connect to a wooded out lot that will not be built on. Close to Hartman State Park and close to town. Building spots for your dream home. Call for more details.
Features Land
|Lot Size:
|Approx Acres: 0.49
|School District: Waupaca
|High School: Waupaca
|Middle School: Waupaca
|Elementary School: Waupaca
|Taxes: $227
|Tax Year: 2016
|Body of Water:
|Lot Description:
|Subdivision: Evergreen Hills


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The Universal UB634 replacement battery consists of (1) High Quality 6V 3.4Ah battery.


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Jon Bon Jovi might still be livin' on a Hail Mary. But his publicist on Monday tried to tackle speculation that the rocker intends to cross the goal line any time soon in his pursuit of NFL ownership.
Specifically, with the Buffalo Bills.
On Sunday reports broke that Bon Jovi, 51, is in cahoots with executives of Maple Leaf Sports and Entertainment (MLSE) to assemble a team to buy the Bills after 95-year-old owner Ralph Wilson dies.
Bon Jovi's publicist Ken Sunshine told John Wawrow, Associated Press correspondent in Buffalo, that his client is not currently pursuing the Bills.
"The Bills are not for sale, and (Bon Jovi) has too much respect for Mr. Wilson to engage in any discussions of buying the team," Sunshine told Wawrow.
Bon Jovi has "a day job that's doing very well," Sunshine said in regard to the rock band that bears his client's surname.
"It's preposterous to say he's had any discussions with the Bills and Erie County."


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No one knows the answer to the mountain's mystery, including C.W. Smith, who has probably spent as much time around fabled Brown Mountain as anyone alive. Smith, 67, spent 33 years with the U.S. Forest Service, patrolling the Pisgah National Forest as a federal law enforcement agent beginning in 1966. He knows every fold of the ridge and is familiar with its marquee mystery, the so-called Brown Mountain Lights. He grew up in nearby McDowell County in western North Carolina and never much believed the stories about nocturnal flickerings. Then while working one night, he caught sight of what looked like a bonfire on the mountain, but in a place where there were no trails. "It started going up the mountain, too fast for someone to be using mountain-climbing equipment. It went up to the ridge line and disappeared." With that, Smith became a believer, he told a symposium on the phenomenon held Saturday at Morganton Municipal Auditorium. "If you ever see them, you'll never forget it because you've never seen anything like it before."Brown Mountain, a rugged lump in the wrinkles of the Blue Ridge, has attracted attention since antiquity because of the lights. Folklore holds that Cherokee Indians thought they were torches held by ghosts of grieving maidens. An early European explorer, a German surveyor named G.W. de Brahm, studied the mountain in 1771 and concluded it vented "nitrous vapors which are borne by the wind." Other theories have been floated through the years.In February 1913, the Observer ran through a few, including dust vented from a mica mine, then added: "Quite a few suspect that some moonshiner, who likes not the limelight, is sending up the light on a kite to frighten his neighbors and others out of that immediate vicinity." A U.S. Geologic Survey later that year concluded people were observing refracted lamps from locomotives on the Southern Railway. Then came the Great Flood of 1916, which washed away tracks and the theory. Trains didn't run for a spell, but the lights stayed on the job...more
Issues of concern to people who live in the west: property rights, water rights, endangered species, livestock grazing, energy production, wilderness and western agriculture. Plus a few items on western history, western literature and the sport of rodeo... Frank DuBois served as the NM Secretary of Agriculture from 1988 to 2003. DuBois is a former legislative assistant to a U.S. Senator, a Deputy Assistant Secretary of Interior, and is the founder of the DuBois Rodeo Scholarship.
Thursday, November 15, 2012
Brown Mountain lights still enchanting
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Figuring out the essentials of the Heisman race is as much about knowing who can't win as who can.
As much as I love Phil Steele, handicapping the Heisman is not about throwing a list of 50 guys against a wall and seeing who sticks. In reality, there's probably only 10 players out there who have a real chance at winning in a given season.
That group usually consists of:
1. Established quarterbacks, running backs or multi-purpose athletes who play for traditional powers or teams in the national title race.
2. Currently unknown commodities from powerhouse schools who have yet to emerge on the scene.
As for who won't win, let's start by throwing out all the linebackers, defensive linemen, defensive backs, offensive tackles, fullbacks, tight ends and non-kick-or-punt-returning wide receivers right now, even though you are certain to, at some point, read an off-the-wall column about one of them having a shot at, or an argument for, the trophy.
They don't.
There is an award for linebackers–it's called a Butkus. There are a bunch of awards for the big uglies–the Outland, the Lombardi, the Nagurski and so on. If you are a fine defensive back, good for you. Go get the Thorpe. And no, I don't care if his coach really thinks he should win. He won't.
Yes, I know that gutty player from a little school going 12-0 is probably going to throw for 5 million yards. Too bad. Unless he really does throw for 5 million yards, he doesn't have a chance in hell of winning.
So Graham Harrell, James Laurinaitis, Armanti Edwards, Rey Maualuga, Travis Beckum, Max Hall, Eric Berry, Jermaine Gresham, George Selvie, Malcolm Jenkins, Taylor Mays, Myron Rolle and the rest of you fine players of similar position out there…..I'm sorry. Some of you may get some votes, but you are not legitimate Heisman candidates any more than Ron Paul is a legitimate Presidential candidate.
Now that this is established, we can move on to talking about who has a chance at actually winning the trophy. Remember, here at HP we look at the race as it is, not how it should be.
He may look tough, but he's no Heisman contenderPowered by Sidelines


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The swim leg in a triathlon is often what keeps beginners from joining in on the fun. Part of this is due to the difficulty of gaining comfort in the water when surrounded by other swimmers and confidence in your own abilities.
So where do you begin?
The center-mount snorkel could be a training tool that could help to solve some of your problems in the water.
So why is the center-mount snorkel so different? Snorkels have been around for quite some time, but there are plenty of advantages to having the tube fixed towards the center of the face as opposed to the sides. The traditional side snorkel was designed to be used primarily with just your legs kicking, and at slower speeds.
More: Swimming Tips for Beginners
The center-mount snorkel is designed to be used at swimming speeds and allows you to maintain proper body alignment throughout. The ability to swim at all speeds with both arms and legs is very significant to the learning process, especially when you are not having to turn or lift the head to breathe. I'm sure when you woke up today, breathing was not on your list of top-20 things to get done, but when you jump into a body of water breathing goes from not even being on your list, to priority number one.
If you took a poll of people in the United States about what the best form of exercise is, swimming would be right up there near the top, if not the very top. Then why don't more people swim? Quite simply because they can't breathe, or they breathe incorrectly or inefficiently.
A person of any ability can learn to breathe correctly through a snorkel. Once breathing becomes natural, a person will then relax, and eventually will not have to consciously think about breathing. Imagine getting up in the morning to go for a run or bike and having to think about every inhale and exhale. It may seem silly, but this is how many people's trip to the pool plays out. The snorkel will allow a person to remove breathing from their mental equation, which allows you to focus completely on your stroke technique.
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A Tale of Two Cities is one of Charles Dickens's most exciting novels. Set against the backdrop of the French Revolution, it tells the story of a family threatened by the terrible events of the past. Doctor Manette was wrongly imprisoned in the Bastille for eighteen years without trial by the aristocratic authorities. Finally released, he is reunited with his daughter, Lucie, who despite her French ancestry has been brought up in London. Lucie falls in love with Charles Darnay, another expatriate, who has abandoned wealth and a title in France because of his political convictions. When revolution breaks out in Paris, Darnay returns to the city to help an old family servant, but there he is arrested because of the crimes committed by his relations. His wife, Lucie, their young daughter, and her aged father follow him across the Channel, thus putting all their lives in danger.
The handsome volumes in The Collectors Library present great works of world literature in a handy hardback format. Printed on high-quality paper and bound in real cloth, each complete and unabridged volume has a specially commissioned afterword, brief biography of the author and a further-reading list. This easily accessible series offers readers the perfect opportunity to discover, or rediscover, some of the world's most endearing literary works.
The volumes in The Collector's Library are sumptuously produced, enduring editions to own, to collect and to treasure
Great book


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Sun dial-it-up
Dunhill Solar Charger
So you want sophistication and mobility without having to buy a Rolls Royce Phantom? For a few hundred thousand dollars less, you can show off your Dunhill Solar Charger. Okay, so it probably won't get you into a posh Manhattan nightclub, nor is it lined with burlwood and rich leather, but it will give you up to 30 hours of juice for your phone or iPod and make you look rather fancy at it. Made of aircraft grade aluminum with the all-important Alfred Dunhill logo engraving, the Solar Charger comes with its own carbon fiber-esque leather case and will utilize both sunlight and USB power to make sure your need for speed on the Drag Racing app gets fulfilled without interruption.
Buy Now: $195


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Project 11's Katie Rae Named Director of TechStars Boston
TechStars, the seed-stage investment fund and startup mentoring program, announced today it has selected tech executive and startup personality Katie Rae as the new managing director for its Boston installment. She'll take over for former managing director Shawn Broderick, who announced earlier this month that he would be leaving his role to focus more closely on his gaming startup, play140, and a professorship position at Boston University.
Rae, who has most recently been working on a new startup accelerator and micro-investment fund called Project 11 Ventures with Reed Sturtevant, will help TechStars find new digs in the Boston area (it's currently housed in Central Square), and add to its roster of startup mentors and early stage investors.
She has been active in the startup and investment scenes in Boston, having served as a judge and mentor for business plan competition MassChallenge and an organizer of the Boston Open Angel Forum. Rae's resume also includes executive positions at Eons.com and Microsoft Startup Labs, as well as a guest lecturer slot at MIT.
As things pick up with TechStars, she'll be backing away a bit from Project 11, which has invested in Boston-based analytics startup Locately and financial services software startup peerTransfer. Rae's blog post on her new position notes that Sturtevant will be taking on more of the Project 11 responsibilities in the spring months when TechStars Boston is in session. Applications for the 2011 program are now open.
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It sure makes you dream, doesn't it? :-) Thanks for your nice comment.
This is wonderful!
Glad you do, Texasstar. Thank you.
I love it! Thanks.
Glad you share my opinion, Pkin :-)
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Superbe !


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Rode around town with my 1 yr old nephew and front faced him!!
:O. How dare i?? While i was driving around i realized he has been ff since he was about 9 months. Oh well. Bash away. :p
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@@ wow.. Poor kiddo.. My kid is 18 1/2 months and will be rearfacing until I decide when to flip him.. If I had known about extended rearfacing with my other two it would be a hell of a lot longer than what I did with them.. But to each their own..
1 mom liked this
Well you're legally allowed to do that *shrugs*
by Platinum Member on Dec. 8, 2012 at 5:16 PM
5 moms liked this
At 1, that is legal. Not safest, but legal.
3 moms liked this
Dude that's what I did wrong.
Quoting Ninjabubble:
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Natural flat brim hat with high pinched crown finished with gros grain trim and finished edge. Designed in Florence by Reinhard Plank.• Designer: Reinhard Plank
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CORVALLIS, Ore. – Oregon State University's forensics team played host to the American Forensics Association District II Regional Qualifier this past weekend. The tournament featured nine schools from the Northwest, including Lewis and Clark College, Pacific University, and Carroll College of Helena, Mont.
The tournament provided students with a chance to qualify for the prestigious National Individual Events Tournament to be held this year at the University of Minnesota, Eau Claire, on April 2-4.
"Our team demonstrated the right amount of competitive spirit and teamwork," said Mark Porrovecchio, director of the OSU team and regional chairman for the American Forensics Association.
The seniors led the team with impressive results:
- Senior Morgan Mansker of Sisters qualified for nationals in impromptu speaking and prose interpretation;
- Senior Forest Ledbetter of Sheridan qualified in impromptu speaking and after-dinner speaking;
- Senior David Kubota of Forest Grove qualified in after-dinner speaking and prose interpretation;
- Senior Andrew Leder of Albany qualified in extemporaneous speaking.
- Junior Loni Sturm of Albany qualified in extemporaneous speaking and was first alternate in persuasive speaking,
- Junior Kyle Bidwell of Sumner, Wash qualified in extemporaneous speaking and was first alternate in program oral interpretation.
- Freshman Afina Neunzert of Tigard qualified in persuasive speaking.
- Freshman Patrick Chambers of Redmond was first alternate in informative speaking.
- Freshman Antonio DiMicco of Hillsboro was second alternate in persuasive speaking.
Unfortunately, not everyone who qualifies will get to attend and alternates fill in only if a qualified competitor drops out. Porrovecchio chose Mansker and Ledbetter to represent the team at the national tournament in April.
"I would take everyone if it was a simple matter of spirit and desire," Porrovecchio said. "Ledbetter and Mansker are seniors who deserve this opportunity."
Other OSU students still get a chance to experience national-level competition. Before the April national event in Montana, the team heads to the Pi Kappa Delta National Comprehensive Tournament hosted by Gustavus Adolphus of St. Claire, Minn., on March 19-21. The team will be represented by Mansker, Ledbetter, Kubota, Sturm, Bidwell, Dalicia Fennell of Sutherlin, and Mayuko Miyamoto of Tokyo.


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Can I still buy an iPhone 5?
Episode 1344LeAnne from
LeAnne wants to know if the iPhone 5 is still a good phone to get. Leo says she could still find them, but the iPhone SE is a better buy because it's essentially an iPhone 5 with a newer processor. It'll likely stay updated longer.


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Smoking Hot Smoking Chicks
I just found out that yesterday was No Smoking Day. Which would make today, Smoking Day. So in honor of the occasion, I have prepared a gallery of the nastiest girls with the nastiest habit. For the record, I despise smoking, and girls that do it. I don't want to smell that crap, and I'm glad they are outlawing it in public across the country. That being said, the majority of these chicks look pretty good. So if they brush their teeth and use a breath mint, I might consider letting them into my bed. Obviously this is a mix of celebrities, and people you have never heard of. Happy Smoking Day, and enjoy.


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Brian Kaufman is a three time national Emmy award winning video journalist with the Detroit Free Press. His style of visual storytelling blends cinematography with traditional still photography and is an intimate reflection of the subjects that he works with. As a one-man-band or working in small teams, Brian's work spans a broad range, from quick-turn daily assignments to long term projects on social and environmental issues. The Society of Professional Journalists in Detroit named him the 2009 Young Journalist of the Year and his work as a photographer and editor has been recognized by a number of other organizations.
After receiving a Visual Journalism degree from Brooks Institute of Photography in Ventura, Calif., Brian accepted a job at the Naples Daily News in Florida, where he helped launch the first newspaper-based television newscast in the country. In 2007 Brian joined the Detroit Free Press, where he has been instrumental in facilitating the education of video journalism to other newspaper photographers and reporters.
Brian's personal work includes nature and wildlife cinematography and adventure travel. From climbing mountain peaks in the Sierra Nevada to exploring Detroit's many abandon buildings, the Canon 5D Mark II has become his camera of choice. Brian's future goals include directing feature length documentary films.


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The U.S. Army All-American Bowl has nominated five high school football players from Utah for the 2013 game this January in San Antonio.
The committee, which includes regional coaches from around the country as well as Rivals.com, nominated 400 athletes from around the country. It will whittle the list down to 90 players throughout the football season this fall.
The five juniors from Utah hoping to make the cut include a pair of quarterbacks, a pair of lineman and a defensive back. They are Woods Cross' Sean Barton (DB), Cottonwood's Cooper Bateman (QB), Logan's Luke Falk (QB), Bingham's Lowell Lotulelei (DL) and Pine View's Logan Stott (OL).1 comment on this story
The final 90 players selected will participate in the East-West match-up on Saturday, Jan. 5 in a game that will be televised nationally on NBC.
Nobody from Utah participated in the game in 2012, but the year before both Bingham's Harvey Langi and American Fork's Ryker Mathews were members of the West squad.
Past local participants in the Army All-American Bowl are: Brighton's Ricky Heimuli (2010), Bingham's Austin Holt (2008), Cottonwood's Lynn Katoa (2008), Bingham's Justin Sorensen (2008), Cottonwood's Simi Fili (2007), Timpview's Matt Reynolds (2005), Hunter's Ray Feinga (2004) and Highland's Haloti Ngata (2002).


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Hey guys, I'm fairly new to coding, in fact, this is the second program I've ever tried haha. I can't quite work out why my loop is terminating early in this program:
All I get as an output, when say putting in 9 as the input, is this:Code:#include <stdio.h> int main () { int fibonacci, fib3, fib2, fib1; printf("What number would you like the series to go to?"); scanf("%d", &fibonacci); printf("%d\n", fibonacci); fib2=1; fib1=0; if (fibonacci = 0) { printf("The series is 0"); return 0; } do { fib3 = fib2 + fib1; printf("%d+\n",fib3); fib1=fib2; fib2=fib3; } while (fib3 <= fibonacci); return 0; }
Obviously it's going through the loop once, before deciding it's ready to terminate without going through again. I can't work out why it wants to terminate without looping through twice. Any help you could offer would be great, thanks!What number would you like the series to go to?9


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Comment #2 Thursday, June 24, 2004 3:07 AM
Comment #3 Thursday, June 24, 2004 5:21 AM
Comment #4 Thursday, June 24, 2004 6:55 AM
Comment #6 Thursday, June 24, 2004 7:50 AM
Comment #7 Thursday, June 24, 2004 8:02 AM
Comment #8 Thursday, June 24, 2004 8:22 AM
Comment #9 Thursday, June 24, 2004 8:25 AM
Comment #10 Thursday, June 24, 2004 8:29 AM
Comment #11 Thursday, June 24, 2004 10:39 AM
Comment #12 Thursday, June 24, 2004 11:25 AM
Comment #13 Thursday, June 24, 2004 12:59 PM
First one is setting colors....anywhere that you can set a color, usually happens with black, if the 0,0,0 isn't showing the skin will show the previous skin's color setting. You have this problem with the Text-Normal under the Window attribute in colors. The little square showed it was supposed to be black, but everything was white on my system, because of the last skin I was using.
Second one is a color issue with the control panel header color not being set so it's magenta with a dark blue gradient.
Also, crissy14 made a good point about reducing the shutdownflag to a 1x1 pixel. A trick I didn't learn until after I did my first skin.
About the startmenu, don't worry about it. Set it up the way you use yours. It doesn't work with 16x16 icons or 48x48 icons, the two other options here. Alternative, if you want would be to include a single substyle with the default startmenu size showing text.
About the color, I agree with IR about the color blue, but that's a personal thing and it doesn't take away from the overall quality of the skin
For future skins, if you haven't created toolbar icons or animations, delete them and the skin will use the default on the user's system. It'll shrink yoru file size around 250K. Hep us poor folk who still be on dial-up and save WC a little bandwidth costs
The graphics are great, the clean and everything is easy to read and use. Has a nice classic look to all the buttons and scrollbar. This skin is very minimalistic and I can see you put a lot of work and thought into it. Good Job. BTW....hope your apetite is up for eating a few floppies LOL you know skinners are going to take you up on it....at least I might, if I can dig up one of the big old floppies, maybe one of those one's you find stuck to the bottom of some mildewy old box, where some little rodent made it's home for the past 10 years yum!! I'm sure I can find one of those
Comment #14 Thursday, June 24, 2004 1:46 PM
Comment #16 Thursday, June 24, 2004 4:20 PM
Nice job Cerebro.
Comment #17 Thursday, June 24, 2004 5:15 PM
Comment #18 Thursday, June 24, 2004 5:19 PM
1.) Hacker Purple
2.) Hacker Green
Just being freindly. In no way bashing your wonderful, rule bending skin!
Comment #20 Thursday, June 24, 2004 5:49 PM
Please login to comment and/or vote for this skin.
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How to exit to Grub without rebooting?
I and my buddy are trying to make a fast-switching dual-boot system for a desktop computer, and we came up with the clever idea that if you could exit to Grub instead of rebooting you could switch to Windows much faster. The problem is that we have trouble finding out if this is even possible, and if so, how to we do it? The ideal thing would be to get Linux to halt/hibernate and then exit to Grub so one could load Windows.
Getting Windows to do the same is going to be the next problem... :D
Nope - there is no way to return to the loader code. kexec offers that sort of functionality for Linux only, but it actually requires 2 kernel to be loaded (resident) in storage.
No chance for Windoze.
Try running as virtual guests if switching speed is your main concern.
Well, if we could get linux to fast switch into Windows then that would be a start since Windows would only be used for gaming and such. A reboot before going into Linux would be acceptable.
But these virtual guests, does it support all the hardware stuff needed for directX or such?
Don't know - I don't need it; others will be able to help there. Can't see why not.
Then there's always "wine" - don't know what the performance would be like for gaming, as again I've never used it.
Okay, hopeflyy we can get this sorted as my friend probably couldn't live without his games... :D
The conceptual problem is that, when you see GRUB, you have not yet "booted" any OS, so talking about "exiting to GRUB instead of rebooting" is almost an oxymoron.
To accomplish your goal of "fast switching," just (as syg00 suggested) run both your OSs as virtual systems on the same box. That way they'd both be running on your hardware, and you could switch between then with whatever "hot key" combination you set up.
|All times are GMT -5. The time now is 11:53 AM.


text: 1. J. Banks CB The pick of CBs in this year's draft. Perfect clay for Coyle to mould into a playmaker. 2a. C. Carradine DE He's a 6'4" mongoose - patient, elusive, fast and lethal. No other pass rusher shouts "difference-maker" to me like he does. 2b. S. Bailey WR The draft's most pro-ready WR, imo. Fast, physical, precise and a TD machine. 3a. Aaron Dobson WR Tall, fast receiver with great timing on the catch and good YAC ability. 3b. M. Hyde CB Under-rated CB who is excellent in press man and has the pace to stay in his WRs hip pocket 4. O. Uzzi OG Mobile, strong guard suited to ZBS. Not big enough for man schemes so should be there in the 4th. Anchor of an O-line that averages around 300yds rushing. 5. J. Stoneburner TE Playing out of position at WR this season, Stoneburner is a great all-round TE - probably the most under-rated in the draft. 6. D. Square DT (/DE) Needs 20 more pounds or so to play DT. Anchors the inside well, but has good penetration ability too and an eye for a sack. A leader and has the work ethic. 7. K. Alonso ILB This guy has mid-round talent, so I'm banking on past character concerns and him being a PAC-12 player in the shadow of Dion Jordan and Michael Clay to slide. It's probably unlikely, but there are a lot of LBs in this draft. Alonso is always around the ball, decisive, physical and holds off blockers or snags opponents with very long arms.


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Bosnia awaits warm soccer welcome in St. Louis
Lionel Messi's last-minute scratch from Argentina's exhibition
soccer game against Bosnia on Monday night isn't dampening
excitement in St. Louis, home to one of the largest Bosnian
communities outside Sarajevo.
The four-time world player of the year injured his leg a week
ago while playing for FC Barcelona and isn't expected to return
until 2014. Argentina had been considered one the early World Cup
favorites, though Argentine coach Alejandro Sabella discounted such
talk at a Sunday press conference. He singled out Germany and host
Brazil as teams to beat.
"The media says that we are the favorites," he said. "We
Messi would likely still have been a secondary attraction for
the 70,000 Bosnians who have settled in St. Louis over the past two
decades after war in the former Yugoslavia. The Bosnia-Herzegovina
national team will join traditional power Argentina in the 2014
World Cup for its first appearance as an independent nation.
After narrowly missing out berths in the 2010 World Cup and 2012
European Championships, that's an enormous point of pride in a
country still beset by poverty, more than 25 percent unemployment
and ethnic division among Bosnian Muslims, Serbs and Croats.
Bosnia's appearance before what should be a highly partisan
"home" crowd wasn't assured until Vedad Ibisevic scored in the
68th minute of a 1-0 win over Lithuania in mid-October.
Ibisevic's family was among the many displaced by a conflict
that killed over 100,000 people. He moved to St. Louis as a teen
and starred for a city high school and one season at Saint Louis
University before turning pro. He plays in the Bundesliga,
Germany's top division. Bosnia is also led by Manchester City
striker Edin Dzeko and German-born playmaker Zvjezdan
The national team's arrival was just about all 16-year-old Adnan
Abdic could talk about as he helped his father and uncle at a
merchandise stand they set up Saturday outside a Bosnian-owned
market in Bevo Mill, the south St. Louis neighborhood once home to
German immigrants a century ago. The high school junior watched
national team's 2-1 exhibition loss to Mexico at Soldier Field in
Chicago in May 2012 and has tickets for Monday's game.
"It's been crazy," he said, describing not only the walk-up
sales of blue and yellow jerseys and pennants but the team's visits
to the Bosnian bakeries, restaurants, taverns and nightclubs that
have revitalized the once-declining neighborhood. "The players are
stars here."
The international exhibition at Busch Stadium is the second this
year. An overflow crowd of 48,263 attended Manchester City's 4-3
exhibition win over rival Chelsea in May. And an August friendly
between Real Madrid and Inter Milan drew more than 54,000 to the
Edward Jones Dome, home of the St. Louis Rams.
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International Silver Co.Water Pitcher: CAMILLE :6017
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- Sold Date:
- Source: eBay
International Silver Company Silver Plate Water Pitcher. This is a significant step above the 1847. This is the pattern CAMILLE # 6017. This pitcher weighs over 2.5 pounds. It is really heavy. It is about 9 inches tall and 5 inches wide. The pitcher is in excellent condition. T are no signs of any wear. This is offered because we must downsize. It is a very attractive pitcher. It will cost well over $ 100 on the used market. You will not find a better quality silver plate pitcher anywere. We do not like to sell, but must. The line are very attractive.


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Ingenuity is a wonderful thing. It combines know-how with imagination to meet any challenge – and it's the driving force behind every special effects job we tackle, no matter how big or small.
Our huge depth of industry knowledge and our culture of experimentation put ingenuity at the heart of our special effects business. We're always trying new things, thinking on our feet and finding new ways to create spectacular moments.


text: + Ralph Richard Cook <ralphc@...>: | I did this in SBCL on Linux: | | * (type-of "hello") | | (SIMPLE-ARRAY CHARACTER (5)) | * (type-of (aref "hello" 0)) | | STANDARD-CHAR | | I guess this means that the #\" reader macro puts a STANDARD-CHAR in | each place in the [ h e l l o \0], and not a unicode character? What makes you think a standard-char is not a unicode character as well? After all, ASCII is nothing but the first 128 character positions in unicode, and I see no reason that Lisp should not support that viewpoint. Here's an analogy: standard-char <-> fixnum, extended-char <-> bignum, character <-> integer. Does that make it clearer? In the early history of multilingual support for emacs, they managed to screw up this sort of thing royally. Basically, charsets such as latin-1 and latin-9 were considered disjoint, even if they are in fact more equal than different. This used to cause all sorts of problems when someone would send me latin-9 coded mail and I would reply, quoting some of their mail: For I use latin-1, and suddenly emacs would complain that letters like ÆØÅ could not be encoded in latin-1. (I believe the brain damage is still there, but now there is clever code working around it so I don't see it manifesting anymore.) In summary, be glad ASCII is a subset of Unicode and not totally disjoint from it. - Harald


text:
Tamara Ecclestone's ex 'tried to blackmail her over sexy secrets'
FORMULA 1 heiress Tamara Ecclestone got a £200,000 blackmail demand from an ex-fiancé, a court heard.
Derek Rose allegedly threatened to reveal 'intimate secrets' about Tamara Ecclestone
Instead, she asked police to issue him with a "warning" after he allegedly threatened to reveal "intimate secrets" to a newspaper if she did not pay up.
Rose, 33, had a relationship with the socialite when she was 17 and the couple were engaged before splitting in 2002.
Tamara, whose F1 supremo dad Bernie, 82, is worth an estimated £2.5billion, has waived her right to anonymity as an alleged blackmail victim.
She told the jury at London's Southwark Crown Court that she preferred Rose to get a warning instead of being prosecuted.
"I said I would like police to advise him if he sends me another email I'd like him arrested," she said. "However, at this time I would just like him warned."
The court heard that Tamara called police after her agent received an email from student Jakir Uddin, 20, posing as Rose's representative, demanding £200,000 in November 2011.
William Boyce QC, prosecuting, said the message was "timed to perfection" as Tamara was appearing on Channel 5 reality show Billion $$ Girl at the time.
Jurors heard the note said there would be consequences for her charity work but stated Rose would sign a confidentiality agreement if the cash was stumped up.
Mr Boyce said: "She was in the public eye and would be damaged by these allegations."
The court heard that Rose had previously sold a story to a Sunday newspaper for £10,000.
Rose, of Camden, London, and Uddin, a media student from Birmingham, deny blackmail.
The trial continues.


text:
Microsoft LifeCam Cinema – Webcam">Microsoft LifeCam Cinema – Webcam
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text:
Margaret Catherine Carpenter, 89, of Grafton, passed away Friday, September 28, 2012 in her home. She was born November 14, 1922 in Strongsville, and graduated from Berea High School in 1941. Margaret's family then moved to a farm in Grafton Township.
Margaret had many hobbies and jobs in her lifetime. She started out as a beautician and loved her job at Buehler's Bakery in Medina for many years. She loved to fish, bowl, roller skate, ride motorcycles, boating and spending time with her family. Many years were spent traveling with harness horses supporting her husband, Dean William Carpenter.
Margaret leaves her sister, Catherine Todd (nee Botsch) and family, sister- in-law, Ramona Arnold and family; she also leaves four sons, William Dean of Grafton, James Lee of Galveston, Texas, Dean Allen of Grafton, and Thomas Charles of Columbus; she is also survived by 11 grandchildren and four great grand children.
She was preceded in death by her husband, Dean William Carpenter; parents, Catherine and Martin Botsch; brothers, Raymond and Martin; and sister, Hildegarde Welsh.
Friends may call in the Blackburn-Duke Funeral Home, 1021 Main St., Grafton, Monday, October 1, 2012 from 6 to 9 P.M. with funeral services Tuesday, October 2, 2012 in the funeral home at 11 A.M. Rev. Dennis Barta, Pastor of Grace Christian & Missionary Alliance Church in Middleburg Hts., will officiate.
Family suggest memorials be made to New Life Hospice, 3700 Kolbe Rd., Lorain, OH 44053.


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Instagram launches Snapchat rival 'Bolt'
TORONTO – Instagram has officially unveiled a disappearing photo messaging app called "Bolt," meant to take on rival Snapchat, just one week after the app was leaked.
The app allows users to send self-destructing photo and video messages to friends and include additions like text captions. Users can only send messages to one person at a time and are only able to have 20 friends on their "favourites" list.
Speculation surrounding the app began last week after some Instagram users reported receiving a notification about a new messaging app on their profiles. However, the link included in the notification was dead.
Bolt draws on features from competitor Snapchat and Facebook's Slingshot app, which was released last month to compete with Snapchat.
READ MORE: Facebook launches 'Slingshot' app, for real this time
But Instagram is owned by Facebook – which means this is the company's second shot at Snapchat.
Slingshot allows users to send photos or videos up to 15 seconds long – but, just like instant messaging competitor Snapchat's app, the images disappear once viewed by the recipient.
Oddly enough Facebook also prematurely leaked the Snapchat app to the App Store before its official release.
Snapchat has seen massive success in the mobile messaging category. Users send over 400 million "snaps" per day, which makes it a fierce competitor for Facebook's Messenger app.
And Facebook has a competitive past with the app.
In December 2012, Facebook released an app called "Poke" that mimicked Snapchat's self-destructing photo feature. But the app tanked and was pulled from the App Store a year later.
In 2013, it was reported that Snapchat turned down a US$3-billion takeover bid from Facebook.
Then in February, Facebook purchased WhatsApp, another popular messaging app, for US$19 billion.
Instagram is initially launching Bolt in New Zealand, Singapore and South Africa. It's not yet clear when the app will launch in other countries.
© 2014 Shaw Media


text:
Heather O'Connor is a 3L. After a seven year marriage and three kids, Heather went through a divorce that left her questioning what to do with her life. She decided to become an attorney and has never looked back since beginning the long journey. She entered a local community college after...
About the Blogger
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Heather's Archive for April 2010
Posted by Heather O'Connor
04/23/2010 at 10:23 AM
I remember back to the days where I didn't know what being a law student actually entailed. I was so excited about everything. The new way of learning, the new material, the new professors; meeting my new classmates - basically I was excited about anything and everything that had to do with being in law school. (You can ask anyone that knows me about how much of a geek I was - I even read "How to Succeed in Law School" books while vacationing in Greece the summer before my 1L year.) Boy, those were the days. The days where I was blissfully ignorant of the way being a...
Posted by Heather O'Connor
04/23/2010 at 10:18 AM
I am supposed to be getting a midterm paper back today. I have a million things to do (nevermind the fact my Spring Break started at 10:15 this morning), but I am sitting at my computer obsessed with checking TWEN every five minutes to see if my corrected paper has been returned yet. Why am I this compulsive when it comes to grades? I am not a very patient person when it comes to results - I like to know exactly where I stand as soon as possible. However, I keep trying to rationalize with myself that it will come in when it comes in. Checking the site every five...


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A popular sauce with Chinese and Asian cuisine. It is a tomato and garlic based zingy goodness which leaves a delicious taste to any dish. This zingy sauce can be used for many oriental dishes. ...
Oriental flavored chicken strips stir fried and served on a bed of methi sprouts and plum salad.
Satay Gai (Oriental Chicken Satay)
Here is a tasty chicken satay recipe. These have been pan fried with the lovely oriental flavors of lemongrass and galangal. Serve with peanut sauce.
Five spice coated boneless pieces of chicken stir fried with onions, ginger, garlic and chillies. Served with steamed rice.
One of Rocky Singh's favorite Thai dish. Chicken mince tossed in mild oriental flavors with aromatic basil leaves.
Prawns cooked in a spicy oriental sauce. This chilli prawn recipe is full of oriental flavors.
Spice up your meal with this chilli gobhi recipe. Cauliflower florets are cooked with an oriental tang. Its quick and easy.
A popular Oriental stir fry recipe with the crunchiness of cashew nuts and sweetness of mangoes. It is also known as 'Ga Xao Hat Dieu'.
A piping hot bowl of hot and sour soup on a wintery evening is all you need. Mushrooms, cabbage and carrots cooked in oriental flavors with chicken.
Mock duck marinated with oriental flavours of hoisin sauce, soy sauce, red wine vinegar, honey and fried golden.
World Cuisine: Know the Difference Between Continental Food and Oriental Food
The major difference between these two kinds of food lies in the regions they are prepared in. Continental food is made in Europe and Oriental food covers the Southeast Asian region
Try Indian, European, Oriental Flavours This Navratri
Move over special 'saatvik' thali servings during the Navratri festival, when several people observe a nine-day fast. Indian cuisine still tops the list during this time, but restaurants are giving foodies delectable options in Chinese ...
10 Best Chinese Chicken Recipes
A few ingredients are common to most Chinese delicacies- ginger, garlic, scallions, soy sauce, vinegar, sesame oil and bean paste. Here are 10 best Chinese chicken recipes, you can try making at home.
How to Make Perfect Singapore Noodles
Forget your memories of takeaway stodge - when done well, this Cantonese creation is colourful, light and nutritiousI spent some enjoyable minutes flicking through a book on Singaporean cuisine, pausing at recipes for prawn laksa, ...
New to tofu? It can be a great addition to stir fries and salads or get a little creative and use it in curries and kebabs, experiment with our best recipes.
Gorge on Sinful Delights This Durga Puja.
From the multifarious Bengali cuisine to the Oriental to the Continental, the world is your oyster when it comes to food this Durga puja - an opportunity for people here to gorge on spicy, sinful ...
Japanese Food Season Kicks-Off in India with Sushi class
Have a strong liking for oriental flavours? Enjoy Oishii Japan or Japanese Food Season, with events like cooking workshops, restaurant promotions, food retail promotions, recipe contests and food festivals organised here and in Mumbai till ...
10 Best Thai Vegetarian Recipes
Thai food ain't about simplicity. It's about the juggling of disparate elements to create a harmonious finish. Like a complex musical chord it's got to have a smooth surface but it doesn't matter what's happening ...
Why I Can't Live Without Fish Sauce: Author Kim Thy on the Tastes of Vietnam
Kim Thuy's second novel, Man, is an immigrant story with food at the heart of it. She discusses food and writing with Guardian Australia.
7 Asian Condiments and Sauces For a Perfect Kick in Your Oriental Meals
Different types of seasonings from Asian countries will provide your cooking the distinctive edge that you've been looking for. Here are the 7 best Asian condiments!


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INDIO, Calif., July 25 (UPI) -- A man and woman in Indio, Calif., were stung by bees 80 and 100 times, respectively, in the woman's backyard, authorities said.
The man, a gardener, was trimming a palm tree Tuesday when bees, swarming on the trunk of the tree, attacked him, and the woman, the homeowner, was stung when she came outside to help him, said Matthew Kotz of the Riverside County, Calif., Fire Department.
Two other gardening workers were also stung, but less severely, the Palm Springs, Calif., Desert Sun reported Wednesday.
Firefighters sprayed foam on the tree to subdue the bees. The victims were largely stung on their heads and torsos, and were hospitalized for treatment of moderate injuries, a Fire Department spokesman said.


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Drive not found!
Hi All,
I wonder if any kind person out there can give Me some advice?
I have recently installed a Extreme II on an Packard Bell easynote SW51-012 (mit drag)AMD Turion 64x2 as the boot drive which now boots and runs ok .
Please pour Yourself a coffee now!
1 Dashboard does not find drive therefore no info or control of usefull functions (trim etc)
Interestingly neither does crystaldisk !
2 Removing and placing the drive in a USB docking station makes the drive visible to D/B.
3 No option apparent in bios for AHCI mode just PIO Multi DMA etc
just shows drive as sata .
So i guess the questions are can I get Dash to see drive, am I losing much performance by not having AHCI option, and which is the best option in My available bios?
There not too bad was it ? feel better just by talking to someone!
Anyhoo roll up roll up test Your brain muscle here mine is spent !
All the best in anticipation JeffH.
Re: Drive not found!
Looks like a tough one but were you able to find a solution to this. Have you tried to ask if a firmware update might be able to help dashboard seeing the drive here?


text:
Guest post by Alexandra Katehakis, MFT, CST, CSAT
Do you grieve your losses or do you immediately replace them? We've all had the experience of losing a cat or dog that meant the world to us, and before we've had time to grieve, some well-meaning friend suggests that it's time for a new puppy or kitten.
If you don't have time for emotional closure regarding how that animal's companionship enriched your life, then the idea of a new pet can feel wrong, insensitive, and disrespectful to your process. Likewise, without proper closure to a relationship, whether three months or thirty years, we're likely ignoring our feelings of grief and loss.
Ending a relationship has many lessons to teach us about how we love, both good and bad. Recognizing where we compromise or withhold, the ways we're giving or controlling, how we can be driven by fantasy over reality, or the ways in which we're selfless or selfish all provide us with data for who we are.
Don't sell yourself short by moving on with someone new if you haven't taken the time to do a proper emotional autopsy on your last relationship. After all, you were (or thought you were) in love with that person at one time. Once you feel complete with yourself about your prior relationship and feel like you've had proper closure with your partner, meaning you're not holding on to any anger or resentment, then, and only then, is it time to move on with the new.
Photo credit: sixwise.com
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Summer in the City
The Party
The Shepherd Center Society hosted its Summer in the City 2014 event at the Greystone Piedmont Park Conservancy. Guests enjoyed cuisine by culinary experts from Atlanta's top restaurants, and tasted wines from around the world. A live bluegrass band on the outdoor terrace, kept everyone entertained. The silent auction items were a huge hit for the attendees as well. The evening raised funds for Shepherd Center's SHARE Military Initiative.
Photography by Adam Davila


text:
Below are poems written by poet
Mansur Aziz. Click the Next or Previous links below the poem to navigate between poems. Remember, Poetrysoup is an environment of encouragement and growth. Thank you.
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Aziz poems
Mansur Aziz
The poem(s) are below...
The Civilian Plants
Mansur Aziz
To the offices they go, the civilian plants,
Wearing suits and pants and ties.
The lifts carry them to the room air-conditioned
And their time becomes naughty with the
Venetian blinds.
Illicit love grasps them-
And the office they change after the transfer order.
Home they come if the bill is belated
Their bodies they bask in the sun
Or with the stars they gossip all night.
The civilian plants sometimes stick to the jam.
Enjoying the CL and PL they attend the office
Only to devour the touch of the corporate girls.
The office PC becomes the stage of songs
Where light like a white cat instigates the civilian ease.
Once the light is off
The black cats occupy the offices-
The civilian plants cry in fear
In search of a pure motherly love.
And then the night like the blank monitor passes
With the pray for a slice of sun through the window.
Translated by Prottoy Hamid
Copyright © Mansur Aziz | Year Posted 2015