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Schools & Colleges
A-Z | Portals | Blackboard | eCollege | Web Mail
Erin Fiene has a Masters in Urban and Regional Planning (MURP) from the University of Colorado Denver, a Bachelors in Organizational Communication from Ohio University and is an overall food enthusiast. Her Master's work focused on the interconnectedness of health and the built environment. Her areas of concentration included Urban Systems such as: food, transportation, access, equity, and policy, as a part of community and economic development. Erin is a Project coordinator for the Colorado Center for Community Development, working on the multiple studies aimed at understanding and creating healthier environments, educational spaces, and equitable systems of accessibility. As a planner, food-systems analyst, garden leader, healthy corner store revitalizer, researcher, food producer and consumer, she believes that every community should be equipped with options and the ability to choose a healthier lifestyle.
© The Regents of the University of Colorado, a body corporate. All rights reserved.
Accredited by the Higher Learning Commission. All trademarks are registered property of the University. Used by permission only.


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- Rather than utilizing the regular meals pyramid, utilizing a vegan meals pyramid might be useful. This particular meals pyramid describes numerous meals organizations as well as meals options which assist contact form the building blocks of the healthful vegan diet plan.
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- . Create meatless alterations. Select foods which could very easily become meat-free having a few alterations. Numerous meals might need 1 or 2 alterations!
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subset: commoncrawl


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EDMONTON - Ryan Smyth believes he still has game.
And while he may have lost a step or two over time, the Edmonton Oilers winger is not ready to be put to pasture.
Absolutely, I feel healthy, I feel great physically, said Smyth Sunday on locker cleanout day. I know my speed isnt the same at Taylor Halls, it never will be, it never was, but Ive earned everything Ive gotten in my career and I want to continue to earn the respect and the opportunity to help this team succeed.
Smyth, 37, had his worse year statistically as a professional this season, scoring two goals and adding 11 assists in 47 games.
Last year, in his first season back with the Oilers, Smyth scored 19 goals and added 27 assists for 46 points in 82 games.
Every player wants to go out and chip in offensively and help out any way that you can, said Smyth. I would have loved to chip in more offensively, but that happens sometimes. Thats unfortunate, but Ill carry on and hopefully next year will be better.
With the Oilers three years into their youth movement, Smyths role with the Oilers was always going to be vastly different in his second stint with the club.
The Banff product left Edmonton in 2007 as a first-line winger, but returned in 2011 as a bottom six forward. Smyth has one more year left on his contract with the Oilers.
I was told right up front what my role was going to be, Smyth said. I dont think it was expected for me to play centre, but they wanted me to be a guy that can lead by example, be an energy guy and help create momentum in a game. Its not a role I am used to for sure, but Im willing to help the team any way I can.


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try re-ripping them. usb is the best way
I have an old Wii that used to be Twilight hacked. I recently used bannerbomb and modmii 4.4.0 to softmod my 4.2 Wii. I added all the correct cios and ios, ios36, cios249, and many others. I use the latest version of Neogamma and also the recommened rev 17 as well as Gecko 184.108.40.206. I tried sys check to see what was wrong and added the necessary missing wads. Many of the newer games only gets past the game menu or the first 2 levels. I'm not sure if there is anything wrong with my actual wii but I can play my Wiiplay and Wiisports perfectly fine. Any suggestions on what to do? Is a USB loader the best way? Thanks in advance everyone!
try re-ripping them. usb is the best way
If I did help you, click on the thanks button , it´s free
How to play out of region games (disc playing) Neogamma
uLoader Priiloader
I did. I burned the same game from a few different places, original and patched, even used different dvd-r and same result. Anyway I can avoid using USB loader?
try to follow the updating old softmod guide. look for it
If I did help you, click on the thanks button , it´s free
How to play out of region games (disc playing) Neogamma
uLoader Priiloader
Has this console ever been sent in for repair? There were alot of these that had the dvd drives replaced with the newer ones according to alot of folks out there.
I tried that guide along with the "mod any wii" guide and another one and thy all have the same results.
Last edited by Krafter; 12-04-2010 at 08:10 PM.
How do the original games work in the disk channel? Do they play? If not then you have a drive issue as oddgriffin was saying. If they do then you have a softmod problem or bad backups.
And please use the edit button in the future instead of creating multiple posts.
Last edited by Krafter; 12-04-2010 at 08:17 PM.
Sorry about not using the edit button. Do you mean to edit my original post with additional information that people ask?
No you don't have to edit your original post. We just don't like to see multiple threads in a row within 24 hours or so. That is considered bumping.
What kind of media are you using for your games backups? Verbatim is considered the best. It is also suggested that you use imgburn to create your backups. You could also have a look at the problematic game guides found in my signature. Maybe it's a known issue with the games you are having problems with.


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Use the tools below to refine your search by only displaying reviews with a certain number of star ratings or to only show reviews from a certain time period. Eg click on '1 star' to just display the reviews we have which received a 1 star rating click or 'Within the last month' to display just reviews posted over the last month.
Written on: 25/09/2009 by richardviled (20 reviews written)
I own an Epson Stylus C48 printer and I am not satisfied with its performance. I happen to have another printer (HP) and compared the print performance (the difference is huge).
C48's print is not of high quality, quite noisy and slower than my HP printer. The only thing good here is the ease of its use and the ink is cheaper.
If you have other options, find something else… Read Full Review
Written on: 12/06/2009
The Epson Stylus C48 is straightforward to use
cheap ink good little printers.
can't complain. never let me down, ink cartridges are cheap and its simple to use… Read Full Review
" MG3000 Series - Terrible Unusable Instructions and Software " Read More
Written by BobfromBanbury
" Promises much, but poor delivery " Read More
Written by TonySomerset
" Still Working " Read More
Written by JoeGlickEsq
" Keep away from this product " Read More
" Constant paper jams " Read More
Written by trader0


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James Wellbeloved Cat Adult Turkey: Reviews
James Wellbeloved Cat Adult Turkey
The ingredients are superb, bursting with flavour in a wholesome recipe that is hypo-allergenic with no unhealthy additives. Cats can suffer from food allergies, giving rise to poor skin and coat condition, and stomach problems. The most common allergies are milk, beef and wheat. James Wellbeloved cat foods contain none of these problem ingredients and is therefore perfect for a hypo-allergenic diet.
From £9.89
Products in this Group
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Cats Love It
posted on 19/09/2017 06:54:14 by hchanshaw
Product Reviewed: 10kg
Pedigree Siamese Seal points both fit and well on this product. Prompt delivery of large bulk bag. good value. Other flavours enjoyed as well.
well tested
posted on 13/07/2017 17:26:25 by lauraine2
Product Reviewed: 10kg
Good food, the cats seem to like it. Fast delivery and free delivery too. Will be buying again.
Great Value
posted on 11/07/2017 17:58:17 by evansdonkin1
Product Reviewed: 1.5kg
Great value, super efficient service, and although I have to keep to strict diet for my dog, cats are able to have a good variety . Thank you.
Good quality food at a great price
posted on 07/07/2017 01:00:51 by Mrs P
Product Reviewed: 4kg
Bought this large size bag as it was on offer. Cats love it. Great food and good quality product.
The Cats Meow
posted on 31/05/2017 14:17:58 by pollygriffin
Product Reviewed: 10kg
I have a small cat home / rescue of special needs kitties. I only feed James Wellbeloved to my rescue and special needs cats . When I take a cat in, it only takes a few weeks of this high quality food and you can see the difference in their coat and behaviour . I know that it is more expensive than the rest but good diet helps to maintain good health.
cat biscuits
posted on 22/03/2017 08:09:42 by mrsgwilliam
Product Reviewed: 1.5kg
poppy loves these biscuits and only that flavour they are well worth paying a bit extra for because she enjoys them so much and keeps her coat in a good condition
Happy Felines
posted on 15/02/2017 14:22:14 by jean42
Product Reviewed: 10kg
We have used your products several times. We have 3 rescue short-hair cats approx. 8 years old and a tabby fellow who simply descended on us later on. He gives a good imitation of Bagpuss, large and cushion shaped. They all love the James Wellbeloved biscuits and consume a great many. It is helpful in the extreme to have them delivered as I can only manage to carry the smaller packs. Thank you.
My cats love this food
posted on 30/01/2017 21:35:21 by Ronnie P
Product Reviewed: 1.5kg
I have always fed my cats on Royal Canin as they seemed to love it but on the advice of a friend thought we would try this one well our cats have gone mad over this and wont touch the R C now only thing is its going to cost me a fortune as they seem to empty their bowls so quick and they start asking for more they LOVE it.
Great product and great value
posted on 04/01/2017 20:40:31 by patchathythe
Product Reviewed: 10kg
I always buy this product for my cat. Find it suits her well and it is great that you can get a large amount delivered at no extra cost.
My two cats love these cat biscuits!
posted on 31/12/2016 12:42:31 by Sue in France
Product Reviewed: 10kg
We have 2 rescue cats, Tigga and Silvi. They both love these cat biscuits and I am happy that they're enjoying food without harmful additives.
My cats all love this food so wil be buying more
posted on 23/12/2016 21:22:53 by G Freeman
Product Reviewed: 4kg
Cats love this food and I have to keep refilling the bowl.
fantastic value
posted on 08/12/2016 01:23:14 by snowy
Product Reviewed: 1.5kg
my two cats just love this dry food. Sammy 3yrs has been on it since she was 1 and Fergus 1yr has been on it since he was a kitten. highly recommend.
Great deal always arrives on time
posted on 12/11/2016 08:46:40 by willlm
Product Reviewed: 10kg
It's a simple transaction - good value and delivery included. I use pet planet all the time
All 3 my cats love it
posted on 12/10/2016 20:58:19 by helensbubbles11
Product Reviewed: 10kg
My female cat is a fussy eater but this food she has always eaten and never gone off it! My 2 boys also love it well worth a try to those considering cat food.
My cats love it
posted on 30/09/2016 14:21:22
Product Reviewed: 10kg
My cats love it better than any other biscuits. One of them who has awful frequent urine/blood problems when eating any other soft/or biscuits from supermarkets, lives on JWB and has no problem whatsoever. She does not have Urinery Track disease and has no Urine crystal problems but cannot stomach any of the normal supermarket foods/biscuits. So it must be something else that is toxic in them. She cannot eat Whiskus, Felix, Sheba(is the worse), Iams etc. They all hate the Science branded soft/hard foods, bland or too big and hard to bite.
We love our food!
posted on 20/09/2016 10:36:29 by Max Trixie
Product Reviewed: 10kg
PetPlanet offer a great price for our food. It was delivered when we told it would be. We are very happy cats!!
posted on 30/08/2016 09:25:34 by Valeriegibbs
Product Reviewed: 10kg
My cats are doing very well on this & they clearly like it. Cats can be very faddy eaters but no so with this product.
Great Value
posted on 09/06/2016 20:17:46 by Elle
Product Reviewed: 10kg
I got this as my vet advised to get a hypoallergenic food for my 2 cats that have sensitive stomaches after a week and a half I am seeing a change In the consistency of their number 2s. I haven't used it long enough to really see a difference in health otherwise but price wise it was the best deal I could find with my local pet shops charging double the price.
Good value, all 3 cats love it.
posted on 20/07/2015 21:06:55 by Leighog
Product Reviewed: 10kg
The cats love this food and the 10kg bag is good value for money. One drawback is storage as unlike the smaller 4kg bags there is no zip-seal top. To get over this I decant the contents into one small container for daily use and one larger plastic box (with lid) to keep the food from going stale.
Fantastic price
posted on 15/03/2015 14:14:54 by JimmyB
Product Reviewed: 4kg
Brilliant product, this food was reccomended to me by my vet for its good quality and apparently it's quite well renound for that. The price is great, you wont find it at a better price elsewhere! My cat love it too, he prefers it to meat
Cat Heaven
posted on 09/03/2015 23:18:24 by Petters
Product Reviewed: 1.5kg
My three cats love James Wellbeloved above all other cat foods wet or dry I tried this as a new flavour for then It went very quickly
Delivered quickly and enjoyed by our cat
posted on 07/03/2015 20:16:11 by nonniehazel
Product Reviewed: 10kg
We have a small black cat and we only give her James Wellbeloved food x28plus a few treats every now and againx29 She is very healthy and glossy and we think this is because of the food 10kg lasts her ages We have always bought through petplanet and have always had a really positive experience
This is my cats favourite food
posted on 26/02/2015 07:49:14 by west1946
Product Reviewed: 10kg
I have 4 cats 3 pedigree and a little moggie The pedigrees were reared on this product and it is there favourite food They will eat wet food too but this is their preference The little moggie loves it too All 4 cats are healthy and full of energy and the vet says its better for their teeth than wet food
Obviously yummy
posted on 31/08/2014 01:11:06 by Buffsta Rhymes
Product Reviewed: 10kg
The cats love it so much that one managed to do a Mission Impossible get into a cupboard that even I have trouble getting into and scratch his way into the bag Hes now on a diet after scoffing so much of it No trouble switching from one brand to another and they seem to prefer it to the fishy biscuits they got before
Brilliant food
posted on 22/07/2014 20:17:15 by angiet
Product Reviewed: 4kg
Our cats adore this product if they could pour it out into their dishes themselves they would We wouldnt give them any other cat food Brilliant service from Pet Planet too delivered as promised the next day
Nutritious and easy to use
posted on 21/05/2014 21:02:09 by A Buyer
Product Reviewed: 10kg
My cats love this They have a constant supply which cant be done with wet cat food but regulate their own intake so extremely easy to use particularly for going away overnight when they can look after themselves
Great quality food
posted on 08/01/2014 12:15:25 by viv in newcastle
Product Reviewed: 4kg
My 3 a moggie and two orientals all love these biscuits The nutrition is excellent quality and its good to know Im giving them the best
My 2 Bengals love this
posted on 22/05/2013 22:26:40 by wilbur
Product Reviewed: 2kg
The best food ever We 2 bengals love this the only other food we will eat is JWB Adult Lamb Rice if JWB ever discontinued these two flavours we would surely die
posted on 08/04/2013 15:52:03
Product Reviewed: 4kg
I bought this for my tonkinese He likes the food but every morning he vomits up bile He practically never vomits normally My other cat liked it but she cant have it as it gives her the runs I introduced this food gradually as youre supposed to with new food
Best cat food there is
posted on 05/03/2013 20:07:23 by Erm
Product Reviewed: 2kg
My cat loves this food When given a choice between JWB and any other dried food he completely ignores the other food
Best for sensitive puss
posted on 07/11/2012 22:33:27 by lynnjunor
Product Reviewed: 4kg
Have a pure white cat with a very sensitive tummy She was painfully thin when we got her from rescue centre She is now a picture of health and tummy not so irritable
Highly reccomended
posted on 05/11/2012 21:50:15 by sue356
Product Reviewed: 10kg
I have been buying James Well Beloved Dried Turkey for years I have a couple of cats that are sensitive and that is how I started buying this product Have had cats for over 30 years So tried many over the years My babies love it Combined with a great price efficient customer service and free delivery and the added bonus of the free cat toy went down a real treat I highly recommend this product and Pet Planet as a supplier
Good food
posted on 08/08/2012 21:23:46 by theitaliangabo
Product Reviewed: 2kg
It smells healthy I havent tasted it though my cats like it I would say it is a good bargain
best cat food around
posted on 27/07/2012 15:04:32 by strawberryac
Product Reviewed: 4kg
the best quality food your cat will get my Smokey loves it and it keeps her very healthy and nice dry poos Your delivery is extra fast and I love the fact you will happily leave it in my back garden as I work in town and not around at delivery times
posted on 18/07/2012 20:44:29 by paulmc7
Product Reviewed: 10kg
Cats love this food. Worth the money for good quality food like this.
Good Service
posted on 18/07/2012 17:11:18 by JAK 61
Product Reviewed: 4kg
My cat Sooty is pleased to be back on on his JWB food as he really likes this and it keeps him in good condition as well. He does have a sensitive stomach but he is fine when he has this food.
posted on 25/06/2012 16:50:47 by Pinkiepie
Product Reviewed: 2kg
in my opinion this is the best dry cat food on the market My kittys look healthy and less mess and smell in the litter trays so im happy too Fast delivery as always
posted on 21/05/2012 12:21:12 by Aramis12
Product Reviewed: 10kg
My cats love their James Well Beloved. They look good on it and prefer it to any other cat food on the market. Pity it's one of the most expensive. That's cats for you, they only like the best!
the cats love it
posted on 16/03/2012 19:45:32 by lisawilde81
Product Reviewed: 10kg
I bought this as I am the owner of 2 cats so we get through quite a lot of food The delivery was super quick and the size of the bag is perfect for our needs The cats absolutely love the taste of the turkey and the duck flavours and always leave their bowls spotlessly clean Xxx
posted on 13/03/2012 11:39:35 by annted b
Product Reviewed: 4kg
My two cats love it and found how much cheaper it is with you I phoned order as not confident with buying on line staff very helpful and patient with me who can get confused Delivery prompt
posted on 20/02/2012 19:47:51 by tim75
Product Reviewed: 10kg
Best Dry food on market
posted on 30/01/2012 10:06:56 by fi
Product Reviewed: 10kg
I have 3 Bengals not fussy eaters but breeder fed them this recommended it they also get some wet food which Im going to be changing to raw soon Thay usually fall over thamselves me to get to this Pricey but absolutley no waste great value for money I buy all 4 flavours of which Turkey is favourite for 2 the other cats favourite is the fish Would thoroughly recommend these biscuits cats give them all thumbs up lol
posted on 22/12/2011 22:13:48 by martin134
Product Reviewed: 2kg
We have 5 cats of varying ages and they all like this It is one of their favourite foods
My Cats Favourite
posted on 13/12/2011 09:15:41 by martinm
Product Reviewed: 10kg
Great Product and Great Price
Cats love it no waste
posted on 08/12/2011 19:56:59 by Lizabird
Product Reviewed: 2kg
I feed my two cats the Fish Rice flavour and they love it They were on Royal Canin previously but I prefer giving them fishy food as I dont like the idea of factory farmed meat They took to it straight away Not one bit is wasted they munch it all up
My cat loves it
posted on 16/11/2011 20:08:22 by joviprincess24
Product Reviewed: 5kg
I have a cat with a chicken intolerance so standard cat food is a big nono He absoultely adores this food I think it stays in his bowl for a max of about 30 seconds
Cats love it
posted on 22/09/2011 16:07:45 by eb579
Product Reviewed: 10kg
Good quality food The cats enjoy it they look very healthy and their fur is soft and in good condition
They love it
posted on 20/09/2011 21:03:51 by DEBs
Product Reviewed: 2kg
Id never used this food before but when i adopted my 2 18 month olds they were used to this food so didnt want to change it and upset them whilst they settled in Theyre now well settled but theres no way ill be changing the food they love it The turkey and rice flavour being their favourite
Pusscats love it
posted on 08/08/2011 22:10:28 by gaynor tilfordbaker
Product Reviewed: 10kg
I have 2 cats an 8 yr old fussy ginger male and a not so fussy 3 yr old female tabby Both of them absolutely love these biscuits having bought all the flavours the turkey seems to be their favourite Its certainly preferable than wet catfood and alot better for them too
Second to noned great value as no waste at all
posted on 01/08/2011 14:41:50 by Sue
Product Reviewed: 10kg
I have two siamese and two birmanall a year old and they all love the adult and kitten food Great value and no waste at all
cats love it
posted on 30/07/2011 09:56:59 by ninja
Product Reviewed: 5kg
excellent food for our cats
Excellent food
posted on 24/07/2011 09:40:47 by Jackie
Product Reviewed: 2kg
All 5 of my cats love this food even the fussy one but hell only eat the turkey and rice flavour This one suits his tummy though as hes a bit sensitiveno more sick I like the fact that its a natural food and find it economical even for 5
Terrific value
posted on 13/07/2011 23:23:11 by Tikey
Product Reviewed: 10kg
My Puddeys favouritehelps to keep her hair soft and shiney
Always feed JW
posted on 13/07/2011 20:14:41 by the beanery
Product Reviewed: 10kg
My 2 cats wont eat any other food everyone says how healthy they look
Been using it for years
posted on 03/07/2011 15:01:55 by Sooze
Product Reviewed: 2kg
I have fed my Siamese cats on JW Turkey and Rice for years and the vet always compliments me on how fit they look and says their weight is just right too I do think the dry all in one foods also help keep their teeth in better condition At bedtime I give them a small amount of either the fish or the lamb flavour which they think is a special treat even though it is just their normal food but in a different flavour
Good Food Good Value
posted on 11/05/2011 20:11:46 by ConcernedCat
Product Reviewed: 5kg
A regular food in this house liked by all the cats I think the Turkey and Rice is probably their favourite flavour
good value
posted on 04/05/2011 20:27:55 by Tracy
Product Reviewed: 5kg
great value for money will last my cats ages my 3 cats wont eat anything else have reccomended to all my pet friends
Good Food
posted on 28/04/2011 09:32:07 by lynn
Product Reviewed: 5kg
In the advice of my Vet, I have been giving my cats JW Turkey & Rice for years and they have done very well on it. I have recently tried them on the Lamb and they enjoy that as well.
Fabulous Cat Food
posted on 06/04/2011 08:34:47 by Sophia
Product Reviewed: 10kg
This is the only cat food our 3 cats will eat, other brands they just pick at and look miserably at us. I was recommended James' Well beloved by the pedigree breeder of our Bengal cat some 7 years ago and we have stuck with the brand ever since. tried a fwe others, but the cats just don't like it. highly reconmmended
posted on 15/03/2011 19:23:44 by juliemclean381
Product Reviewed: 2kg
A product that has been going a long time.Good value for money.A Hypo-allergenic biscuit which I put my cats back onto after some developed a food allergy, itchy skin, whilst eating another well know brand. They are not keen on the Turkey&Rice but love the Duck&Rice and Lamb&Rice.
posted on 12/03/2011 16:20:21 by ChapelHouseKitties
Product Reviewed: 2kg
We have five cats - DSH Moggies, all! Two of them have delicate innards. This food is the only brand we have tried which has stopped the looseness. All of them love the flavour and eat every morsel. More expensive than some brands, but my contented cats purring at their bowls says it all!
Good value
posted on 08/03/2011 08:12:40 by charity
Product Reviewed: 10kg
Feeding 10 -16 cats everyday requires a good value quality food and JWB meets the requirements. As a charity we have no money to waste and need to shop where the price is right. Delivery was quick.
James wellbeloved
posted on 24/02/2011 15:49:56 by Stevie B
Product Reviewed: 2kg
We have 4 cats, 2 British shorthairs and 2 Bengals,and they ALL dive in the minute it is put down, and thats with all 4 flavours. There is no waste and the food is top quality.
excellent value
posted on 24/02/2011 09:38:12 by macliz17
Product Reviewed: 2kg
excellent value for money well happy and recieved it within a few days liz
My two cats love James Wellbeloved Cat Food
posted on 09/02/2011 17:24:56 by D Schwab
Product Reviewed: 2kg
I used to feed my cats JW turkey and rice but thought they might enjoy some variety and this time purchased JB lamb and rice. They both love it and I will try the remaining two varieties as well.
My 3 cats love all the JW varieties
posted on 06/01/2011 11:28:02 by nicki-longmore
Product Reviewed: 2kg
Lamb is their favourite at the moment but they enjoy all the varieties. They all have lovely coats, bright eyes and lots of energy !
good re- seal on bag
posted on 04/01/2011 19:29:14 by david buckingham
Product Reviewed: 2kg
cats love it
Good well balanced food
posted on 04/01/2011 19:14:21 by shadders
Product Reviewed: 5kg
l feed my cats on JW because it is full of goodness. Different flavours mean they don't get bored. Easily digestable, so great for cats with tummy problems. Wouldn't touch supermarket dried food [yuk]Happy well fed purrs..happy me!!
Excellent value
posted on 24/09/2010 08:14:17 by Monica
Product Reviewed: 10kg
Ordered items from Petplanet for the first time.I must say, I am a very happy customer and will order again. Delivery time was fast. Product is as described. Thank you.
Great Good
posted on 22/09/2010 13:05:33 by wool8911
Product Reviewed: 10kg
My Cats love this food. and it is is the cheapest anywhere.
Excellent value
posted on 16/09/2010 21:46:31 by susan
Product Reviewed: 10kg
My last cat loved it. I have four now and they all like it. It doesn't have the "cakey" smell that Science Plan has and they all have beautiful coats, even the one that treats my house like a hotel...
My Cats love it
posted on 03/09/2010 20:14:36 by dazmaz1
Product Reviewed: 10kg
Both my cats love this, it gives them a nice shinny coat. They where on Hills but they seem to enjoy this more.
Gentle on there stomachs!
posted on 26/08/2010 20:57:33 by Hannah
Product Reviewed: 10kg
I love this food. Before I was feeding Iams and one of my cats started having bad diahorea and being sick alot. This happened repeatedly when I restarted it. However, I cannot speak highly enough of James Wellbeloved; it has solved the problem, is excellent quality and my cats absolutely love it! Plus excellent value on this site. Thanks.
My cats love this and they are very healthy
posted on 22/08/2010 12:35:11 by Amanda
Product Reviewed: 5kg
Vet recommended I switch to JW from the normal food from the supermarket, as my cats had tummy upsets. They are both doing really well now and look even more beautiful!
posted on 01/08/2010 17:22:43 by michelle-elliott
Product Reviewed: 5kg
The item arrived within the stated time-frame and although the packaging was adequate it did have one major drawback (in my case), the packet containing all the nuts and bolts was not securely sealed so the contents were loose in the box and scattered all over the floor as I removed the the frame. The instruction leaflet, although detailed, wasn't as clear as it could have been and it advised that it was a two-person job to construct it and I would certainly endorse this view. However, once erected it looked good and served my purpose well so I would recommend it to any interested buyer.
My cats love this
posted on 25/06/2010 11:28:19 by paddiwak
Product Reviewed: 2kg + 1kg free
My cats go crazy for this food.
posted on 22/06/2010 16:27:18 by Wendy
Product Reviewed: 2kg + 1kg free
MY 4 CATS LOVE JAMES WELLBELOVED FOOD, AND NOTHING ELSE WILL DO, THE DELIVERY TIME WAS EXCELLENT, BEING DELIVERED THE DAY AFTER ORDERING. the stray cats love it too.
my Burmesecat loves it
posted on 01/06/2010 17:17:30 by joyla
Product Reviewed: 2kg + 1kg free
Very good quality and value and one cat already loves it but my Bengal only eats dry food when she is bored with the wet food. I believe that she will convert to the James Wellbeloved because has the best ingredients
my cats love it
posted on 27/05/2010 09:10:33 by clarebrown1
Product Reviewed: 2kg + 1kg free
my cats will not eat anything else but James Wellbeloved. It is good value and none is wasted.
Best of all.
posted on 08/05/2010 11:08:40 by Pat (ex breeder Hull)
Product Reviewed: 2kg + 1kg free
This seems to sit well on my cats tummies and I have far less throwing up than I have got with other dried food.
posted on 07/05/2010 17:32:34 by sallygold1
Product Reviewed: 2kg + 1kg free
I have been feeding my cats for years with James wellBeloved Lamb and Rice. Tried a few others but alway return to this. The same is true for my Labrador. Free Delivery and Special offers here make PetPlanet my regular Suppliers.Thank you.
Healthy kibble!
posted on 04/05/2010 01:29:20 by PetLoverNirvana
Product Reviewed: 2kg + 1kg free
My cat loves this!
My cats love it.
posted on 25/04/2010 15:10:17 by birchwoodlassyahoocouk
Product Reviewed: 10kg
I have 7 cats and like to give them the best food i can. My usual brand is IAMS, but when i saw the price of the JAMES WELLBELOVED i had to buy it, i know its dear but its a wonderful food for them and they love it.
posted on 22/04/2010 09:39:37 by tumblyboo
Product Reviewed: 2kg
i find this to be excellent - high quality, good value, and cat loves it. good for their teeth and health and (for humans!) much less messy than "wet food". all they need apart from this is water.
good product
posted on 03/04/2010 20:13:05
Product Reviewed: 2kg + 1kg free
good for all my cats. Easily the favourite of many other brands. Pity there isn't a chicken version...
Our cats love it
posted on 02/04/2010 18:09:27 by Pip
Product Reviewed: 10kg
They both like this food, we shall definitely continue to buy it
posted on 08/03/2010 21:27:17 by KATWAL
Product Reviewed: 10kg
Lasts 4 - 6 months for 3 large adult cats. Most popular variety. Cats have glossy healthy coats. Easy to order and excellent delivery. Thank you.
posted on 25/01/2010 11:22:04
Product Reviewed: 5kg
cats love it
The cats love this
posted on 11/01/2010 20:41:45 by monkeymax1905
Product Reviewed: 10kg
My mum recommended this product to me. We feed this to our two cats every evening, with wet food being given to them in the morning As a result, the 10kg packet has lasted us 3 months. The cats actually prefer this to the wet food. Great value, and Pet Planet are a very relaible company to buy from, providing really good value for money. Highly recommended.
My Cat Love's It
posted on 08/01/2010 02:41:13
Product Reviewed: 5kg
Excellant service at Pet Planet as usual. Great website, easy to use and fast.
My cats love this!!
posted on 25/12/2009 15:39:36 by d-rugg
Product Reviewed: 5kg
Excellent product
My Cats have never eaten any other dry cat food and they both do very well on this.
posted on 19/12/2009 12:35:53 by whitmorez
Product Reviewed: 5kg
Great value for money, thanks
posted on 14/12/2009 19:23:07 by jaynemalley
Product Reviewed: 5kg
My cats are happy on this, it is a high quality food, there is no waste unlike wet food, and they are in tip-top condition with beautiful glossy coats.
Great Price
posted on 14/12/2009 11:38:55 by portia10
Product Reviewed: 10kg
Cheapest I could find this on the internet. Delivery was quick too and good job as I was nearly out of food for my little girls!! Will not hesitate to use again and have told my friends about the service and price on this site!
Excellent quality food
posted on 14/12/2009 09:50:27
Product Reviewed: 10kg
I have only fed James Wellbeloved for a long time now after discovering that one of my cats, who had terrible 'tummy' troubles with dire consequences we can all imagine, could eat it without any adverse effects whatsoever. All 3 cats love it and I consistently find that Pet Planet's price and free delivery are excellent - and I always 'shop around' before I buy!
Exceptional value
posted on 12/12/2009 20:45:35 by jbolt4
Product Reviewed: 10kg
Cats have always liked this food. Stopped buying it when others were better value
posted on 28/11/2009 20:29:31 by suzy
Product Reviewed: 5kg
my indoor siamese cats love this food one of them is a fussey eater and enev she likes this food i only buy what they like so it good they do this in a big bag pet planet are great to fast with sending the order out to an pluse i got a nice free tin thanks pet planet i also order from here
posted on 20/10/2009 06:46:59
Product Reviewed: 10kg
our cats love james wellbeloved and it seems to last forever so altough the inital outlay appears a lot when broken down over the time it last then it is very good value.
love this food
posted on 14/10/2009 15:11:56
Product Reviewed: 10kg
Cat's love it!
posted on 13/10/2009 07:53:55 by Jaime
Product Reviewed: 10kg
Our cats were running out of food and found the reviews to be helpful. The cats were on a different brand, but I thought I would try James Wellbeloved since it received great reviews. I have to say our cats really enjoy it! I do notice that our long haired cat doesn't shed as much, it's either that or the weather is changing... Anyway, the delievery was fast and it was hassle free. I would recommend this product as well as PetPlanet.co.uk for ordering things.
Good Value
posted on 07/10/2009 15:14:41 by No more worries
Product Reviewed: 10kg
All my cats like it. They prefer the turkey and rice to the other varieties. Lamb is also well liked though. I feel that this brand does look after the two boy cats urinary tracts. One of them was fed on an alternative brand for two years but got problems urinating and eventually had to be circumcised. I have 3 cats two five year olds and one of eighteen months. We have had no problems since feeding them on James Wellbeloved biscuits.
Good quality and easy
posted on 25/09/2009 22:36:21 by LizM
Product Reviewed: 5kg
My two cats really love the fish version of James Wellbeloved. Its so easy to feed too, as I just leave some out and they help themselves. They never seem to eat too much. Its full of good stuff too, with no additives. I also foster kittens for the local cat rescue, and even though I give them meat and kitten biscuits, they always go eat the James Wellbeloved.
Loved by fussy moggies
posted on 24/09/2009 15:09:28 by trishvoisey
Product Reviewed: 5kg
Good quality product, cats love it and its a good price too
Great service again
posted on 01/09/2009 12:55:26 by Becca
Product Reviewed: 10kg
As usual, the delivery was very quick - I can usually order one day and know it will arrive the next, even when ordered late in the day. The order was left in a safe place, as requested. The quick delivery, along with it being free, means I won't buy my cat food anywhere else now. Thank you.
Great product at a great price
posted on 27/08/2009 08:57:23 by mike-payne
Product Reviewed: 10kg
I've bought this for my cat who has an extremely sensitive digestive system. He loves it. I used to buy it from another website but moved to pet planet when the other site's price inexplicably went up by �20 for a 10 bag, making it �20 more expensive than this site.
My cat loves these biscuits
posted on 27/08/2009 08:57:20
Product Reviewed: 2kg
My cat is thoroughly enjoying these and Iexpect to order them again.
Loved it.
posted on 13/08/2009 10:47:04
Product Reviewed: 5kg
My cat loves James Wellbeloved Cat Food, it doesn't matter what 'flavour' I buy they love.
cats love it
posted on 12/08/2009 15:41:21 by sheenasimpson2
Product Reviewed: 2kg
Cats come running when they hear it being poured into their dish. Good food and good value for money.
posted on 03/08/2009 13:17:45 by charlotteletitia
Product Reviewed: 5kg
i have a fussy siamese, but even he noshes down on this, he looks healthier since he's had it too.
Good as always!
posted on 29/07/2009 14:19:24 by Tom Brighton
Product Reviewed: 5kg
Thought I'd upgrade to the 5kg pack as my two cats gobble it down so fast! Also the free treats helped! Went with Turkey this time as they have had the Duck which they loved and a sample of the Fish which they also loved so thought I'd try them all! Only lamb to go! Still maintain that JWB uses the finest ingredients and we're actually starting to see the results in their coats condition and shine now so the proof is in the pudding!
Great value & Excellent Product
posted on 23/07/2009 21:25:11 by lucyglover
Product Reviewed: 10kg
This is an excellent product. My vet recommended it, as one of our cats is always suffering with stomach problems. Since we have put her on James Wellbeloved all of the problems have gone away & she is healthier than ever. This big bag will last a number of months with two cats so is excellent value.
posted on 23/07/2009 11:14:00 by Clearlybee
Product Reviewed: 5kg
Great value
posted on 09/07/2009 15:12:51 by dickson942
Product Reviewed: 2kg
Loved by the gang of four Siameese cats and may I add excellent delivery by DHL. two days from placing order to delivery. Well done and many thanks.
posted on 07/07/2009 06:56:52 by sarahb6
Product Reviewed: 5kg
My 2 reasonably old cats love this dry food. It's gentle on their stomach, keeps their coat shiny and they seem really happy. What more do you need!
good value
posted on 03/07/2009 14:17:56 by iris-palmer
Product Reviewed: 2kg
having had to change my cats to this brand re dietry needs, they have taken to it very well. The prices in shops are astronomical so good to get it a bit cheaper was excellent when they had it at �8.00
Good nutrition
posted on 30/06/2009 11:44:59 by JoA
Product Reviewed: 2kg
Giving, this excellent, nutritious food, to my cat, makes me want to purr, with smugness because, I know that, he is eating food, with all the best, nutrients, oh & he purrs too!
My cat loves it!
posted on 24/06/2009 22:59:47 by jen-hikins
Product Reviewed: 10kg
I bought the largest packet size and wondered if I had made a mistake. "What if my cat doesn't like it?", I thought. Luckily my cat does like it and never leaves a scrap of it in her bowl!
good value
posted on 17/06/2009 21:36:16 by totohonda
Product Reviewed: 5kg
Doesn't appeal
posted on 28/05/2009 17:38:12 by linda-collinet
Product Reviewed: 2kg
JWB is good for our two ragdolls stomachs, however they don't seem to like it. They make a big fuss and only eat it once they are absolutely starving. The fish one is even less popular with our two boys.
Good Value Purchase!
posted on 27/05/2009 20:42:59 by spalding-home
Product Reviewed: 10kg
Excellent quality cat food which I have bought for 6 years now. All the research shows that James Well Beloved JWB is one the very few complete dry cat foods that does not cause digestion problems or urinary function problems. JWB is NOT tested on animals unlike one of the other popular quality cat foods. PetPlanet was the very best Value for Money I could find on the internet and the purchase was relatively straight forward and arrived in acceptable time, given the FREE POSTAGE!!! Many thanks!!!
My cats love it
posted on 15/05/2009 09:36:11
Product Reviewed: 5kg
I have two cats and they have a permanent supply of dried food - this one goes down faster than all the others put together! That says it all for me.
My cats purr with delight with every meal
posted on 12/05/2009 22:59:43 by CB
Product Reviewed: 2kg
Although it is a pricey product, James Wellbeloved is worth every penny. I bought this on promotion for my two cats as I knew from trying some samples that they love JW but could never afford it. The ingredients are crystal clear and JW is absolutely foolproof: you pay the price, you get the corresponding quality. I will continue buying it as I find they don't need as much per meal as with more generic brands and that their coats have improved in shine, their breath is a lot more agreeable, as for the rest, well, you get the gist. It is a very valuable product.
3 tempermental cats loved it!
posted on 11/05/2009 17:15:13 by Sarah
Product Reviewed: 5kg
I have three very fussy cats, due to one overgrooming and another not long recovering from an accident I thought it was time that I upped the quality of the food. I thought I may have to have a "change over" period of time mixing the whiskers cat food with James wellbeloved, no need for my concern, each and every bowl has been licked clean
my cat loves this stuff!
posted on 23/04/2009 23:44:37
Product Reviewed: 2kg
My cat doesn't get fussy as he has never tasted or wanted anything else.
Cheapest price I could find and free delivery too!
posted on 23/04/2009 19:01:50 by carolwuk
Product Reviewed: 10kg
In the current climate reasonable prices and free delivery are very much appreciated.
He loves this
posted on 18/04/2009 07:03:50 by audreycope1
Product Reviewed: 2kg
My cat absolutely loves this. If I take a handful he will follow me anywhere, climbing onto furniture to get at it. Slightly pricier than his usual Whiskas dry food but worth it because he enjoys eating it.I'm not going back to Whiskas.
Great value
posted on 15/04/2009 09:23:31
Product Reviewed: 2kg
We have to fussy cats and this is the perfect food for them. I also mix it with the kitten range as our cats have sensitive tummies
A favorite
posted on 04/04/2009 09:44:44
Product Reviewed: 2kg
James Wellbeloved is an old favorite of my crew, they all like it without exception. I can even give it to my grain intolerant cat. I will definately continue to buy this.
Good Food
posted on 18/03/2009 18:06:05 by paularit
Product Reviewed: 5kg
From what I've heard and read, this is a healthy, nutritional brand to feed your cat and I'm going to stick with it. The cats all love it.
My cats love it
posted on 10/03/2009 20:37:52 by claire-r-campbell
Product Reviewed: 10kg
My cats aged 13 and 5 have been on this product for several months now and I can really see an improvement in their general health: they are sleeker, more active, cleaner and brighter-eyed. In addition, the delivery service is very efficient so I a motivated to continue buying this product from you.
Really good value
posted on 06/03/2009 14:32:31 by K. D. Osborne
Product Reviewed: 10kg
My two cats, now almost 4 yrs old, have always been fed on James Wellbeloved and enjoy all the flavours. Being a dry food it is left down for them 24/7, together with a bowl of water which they share with the dog!so they eat as and when they wish. This practice is favoured by their vet.
They like it and it makes their coats glossier
posted on 06/03/2009 07:11:00 by Sidsmum
Product Reviewed: 2kg
It's very good and my only criticism is the price. If I had less cats, I'd be happy to feed them on this exclusively. As it is, it has to form part of a more mixed diet.
Cats loved it!
posted on 24/02/2009 18:45:46
Product Reviewed: 2kg
My 3 cats just love this food, one has a sensitive stomach and this food causes her no upset at all.
Best value with speedy delivery
posted on 24/02/2009 14:52:09 by lhignett
Product Reviewed: 10kg
I have 4 Tonkinese cats who, as you can imagine, manage to eat their way through a fairly large amount of cat biscuit each day! I have found Petplanet provide an excellent service both in terms of value for money but also a cost-free delivery which has arrived within a couple of days of my order. When I had a query, it was dealt with professionally and a resolution was immediately found. I would thoroughly recommend that pet owners use Petplanet - I have a busy working and home life and this service has cut down on my need to find time to travel to a pet supermarket.
Great value.
posted on 16/02/2009 17:30:42
Product Reviewed: 10kg
This food is excellent value for money and all my cats are fed on.
posted on 16/02/2009 13:00:03 by smallhog
Product Reviewed: 10kg
Obviously there are greater savings to be made when buying cat food in larger amounts. How then do you get it home, especially if you don't drive like me!? Also, a lot of pet shops don't even stock the largest bags. Pet planet's online shop solves all of these problems and has been painless every time I've used it! Definitely recommended! ...And the cats love the food too -
posted on 12/02/2009 12:15:31
Product Reviewed: 2kg
he loves it
posted on 04/02/2009 20:27:43 by Bailey
Product Reviewed: 2kg
Decided to try this for a change for my Persian cat Bailey as he usually has the Royal Caine Persian dried food. A good product have tried the fish flavoured one but he wasn't as keen, but enjoys the Turkey flavour for a change from his other, now and again. Would recommend this to other cat owners. Also better value from this site.
Great value, cat loves it and we don't need to worry about buying food for a few months!
posted on 02/02/2009 12:40:38
Product Reviewed: 5kg
Food arrived well packaged and on time. Great service!
excellent value
posted on 29/01/2009 12:42:38 by tabby
Product Reviewed: 2kg
One of the best Cat foods one can buy. My ten year old Cat is very healthy has never eaten any other food. He looks and acts much younger, has a wonderful shiny coat and bright eyes. His preference is Turkey and Rice flavour.
posted on 28/01/2009 13:51:18 by back2evans
Product Reviewed: 2kg
good service
Cats' favourite
posted on 19/11/2008 21:33:25 by Cazzy
Product Reviewed: 5kg
Our 2 very-choosy Bengal cats LOVE this food: they wolf it down greedily & their bowl is left empty regularly - rather than turning their snooty little noses up & walking away in disgust, as they do with most food! Good price from PetPlanet - & swift delivery - thanks.
My two cats love this range of dried food - as they're both very fussy I know this won't go to waste and they will be getting good nutrition.
posted on 19/11/2008 13:32:20
Product Reviewed: 2kg
very good value
posted on 14/11/2008 18:19:18 by cob65ler
Product Reviewed: 10kg
good service prompt delivery and a good price i cant fault petplanets service
good value
posted on 11/11/2008 09:48:44 by mary65
Product Reviewed: 2kg
food delivered when expected
posted on 31/10/2008 10:21:47 by M Wadey
Product Reviewed: 2kg
Our cat can be fussy although she gives up when she realises nothing else is coming but when we realised she was pushing the samoyed out the way of his own food, we decided to start buying the cat version of JW for her. She's much happier, it's not too expensive esp. on this site! and what can I say, she obviously knows what's best for her.
posted on 18/09/2008 19:56:48
Product Reviewed: 10kg
I buy the Turkey and Rice for my daughter's three cats. They refuse to eat anything else which must point to something good about the food. They looks healthy and have shiney coats and bright eyes.
My cat loves this!
posted on 09/09/2008 19:22:52 by Junehodge183
Product Reviewed: 5kg
I was delighted with the speed of the service and, not only that, but my cat absolutely adores the James Wellbeloved Turkey & Rice mix. She's looking healthier and happier already and it's only been a few weeks since I bought it. Highly recommended.
My three Abys love this!
posted on 30/08/2008 18:03:32 by DM
Product Reviewed: 5kg
My three Abysinnian cats think this is the best dry food available although they have a choice of Hills & R.C. I have to replenish their bowl of James Wellbeloved Turkey and Rice at least 4 times against the other brands!
Both my cats love it.
posted on 04/08/2008 21:45:14 by Mollyrock
Product Reviewed: 5kg
Seems excellent value here at Petplanet and they both love it. I do half and half with Royal canin hair and skin for my Bengal and no tummy problems at all.
My cats loved it
posted on 30/07/2008 12:07:01
Product Reviewed: 10kg
Good price and free delivery what more can you ask for. My Bengal and Ragdoll cats love these two flavours. Thanks
cat loved it
posted on 23/07/2008 19:32:27 by tigger
Product Reviewed: 2kg
good quality
posted on 14/07/2008 21:53:45 by andrea
Product Reviewed: 2kg
our bengal stud boy loves it
My cats love James Wellbeloved
posted on 03/07/2008 09:49:04
Product Reviewed: 2kg
If you want to give your cats the best diet around and see them in the best possible health then this is the stuff. They love every flavour there is and gobble it up with gusto. I have the peace of mind of knowing I have fed them good natural food. I would almost eat it myself!
This was recommended by a Maine Coone breeder
posted on 26/06/2008 19:06:44 by Meggie
Product Reviewed: 5kg
We always use this food for our Maine Coone cross cats, now around eighteen months old. They love it, and are both thriving and full of mischief
So far so good.....
posted on 19/06/2008 18:32:21 by Cocker Spaniel Owner
Product Reviewed: 5kg
Our indoor cats Ragdolls have been brought up on Royal Canine Indoor Cat 27 for the past three years, and although we find this to be very good, more recently our cats started to be sick after meals on the odd occaison. Since we have changed to James Well Beloved, we have noticed that this hasn't happened and the cats love it! Our dog is on James Well Beloved and she loves it too and recommended it to our cats!!!
Delivery :
posted on 11/06/2008 18:16:32 by nbromhead
Product Reviewed: 10kg
Bit disappointed that this didn't arrive within the timeframe and I had to phone to seek its whereabouts where I was told it had been sent - only to then to to be advised once chasing courier that indeed it hadn't and had to wait for resending. Didn't get money back though as think it said on website : but other product arrived promptly, so prob just a one off
Good quality cat food
posted on 26/05/2008 21:22:14 by PetHeaven
Product Reviewed: 10kg
My cats love this dried food, and I have been feeding it to them ever since one of my cats became very ill with a bowl infection. The vet advised me to feed the cat a hypoallergenic food and so I tried this one after trying a number of others. This was the one my recovering cat preferred and now they all eat it.
great product ,good price, great delivery
posted on 14/05/2008 12:53:16
Product Reviewed: 10kg
my cat phobie loves this
just excellent
posted on 13/05/2008 20:54:32 by arrieanna
Product Reviewed: 2kg
I have used JW foods for many different pets in the past including cats dogs and ferrets. all have thrived on it, though i had to use a different formula RC sensitive lately for my bengal with digestive problems. i love the all natural formula
great product
posted on 12/05/2008 11:28:39 by dj
Product Reviewed: 5kg
Great product which the cats love!
Cats Love It
posted on 03/02/2008 19:10:38
Product Reviewed: 5kg
I have tried other cheaper dry foods and one cat was always sick so changed to tinned food but can't stand the smell around the house (or in the litter box!!!!) read reports about the poor quality of commonly used pet foods and decided on James Well Beloved as its all natural and not full of ash and animal by products. It may be more expensive but the cats love it and I do not get any sick anymore. Well worth every penny I only wish I had discovered it earlier. They also eat less of it as it obviously fills them up more so I guess is more cost effective.
it's the best
posted on 19/03/2007 20:08:09 by alison
Product Reviewed: 5kg
My cats leave an empty bowl so they must like it. Tried cheaper ones but they turn there nose up at it
posted on 12/03/2007 20:12:40
Product Reviewed: 10kg
I use 10kg Turkey and rice, this is an excellent high quality complete cat food. It gives my show cats excellent coats and helps maintain their teeth. I feed this to Devon rex,s Ocicats, Maine coons, and Norwegian forest cats as well as my Moggie. I have tried every brand of cat food and this is the one, i stick with my cats are always eager to eat it. It suits my Maine coons whom one has allergies well done best dry food there is
Cats healthier on this
posted on 10/02/2007 14:40:35 by Maggie
Product Reviewed: 10kg
I put our cats on this after they got ill and the vet recommended dried food. I tried them on some other brands, but this was the only one they could stomach - so the hypoallergenic claims seem to be true. Yes it's expensive, but I'm sure it's working out cheaper buying this in bulk than the wet food we used to get. My cats were always prone to vomiting after food - on James Wellbeloved this happens once in a blue moon. Oh, and while it might look a bit dull to us humans, the cats love it. They come running when they hear the tinkle of the biscuits in their bowls.
Cats love it
posted on 07/02/2007 16:16:41
Product Reviewed: 10kg
Great value bulk pack. Cats have always loved it - particularly the duck and rice - wouldn't buy anything else
Simply the best
posted on 30/01/2007 19:56:08
Product Reviewed: 10kg
This is the staple diet for all four Ragdolls. Since being on J W food their coats have improved, there is less in the dirt trays!! There is no smell around the feeding area, except for the scent of turkey.
Simply the best!
posted on 30/01/2007 16:33:49
Product Reviewed: 2kg
I first discoved James Wellbeloved cat food 6 years ago and I've bought for my Birmans ever since. They really love this food and I'm happy knowing that there eating the best quality food available.


text:
|Reviews for To Rebuild With Ashes
| Guest chapter 1 . 4/9
OMG! Sorry this has nothing to do with the story but I love you're profile picture! ITS SOKKA! FROM AVATAR THE LAST AIRBENDER!(squeals like a fan girl...which I am)
| KNR chapter 1 . 12/6/2004
Dear Sunfreak,
Star-chan here. Just writting you on yet another good story. I must praise you on capturing my attention to the point were I am reading all the poems on your list that I know the story too. Loved this one. Didn't get it at first though. Had to ask a friend to explain it to me. Wow I feel stupid; but, I still greatly injoyed it.
~ Starlit-Knight
| Hush Puppie chapter 1 . 12/7/2002
Heh heh. I like this. Kind of cute, in rather odd way.
| Wingleader Sora Jade chapter 1 . 7/22/2002
*contemplates* Good, but I still like your Wild Eagle one better. *drools* Jamie... If you really love Jamie so much, read "Cunning Wolf" by SuperKat. It's really, really, really good.
| Yami-kun chapter 1 . 7/22/2002
Whoa...great poem! I loved the lines:
To become truly great, you must destroy your life,
Then see what remains in the wreckage,
And rebuild with the ashes of your beautiful dreams.
Once again, great poem!


text:
By Keith B. Richburg
Washington Post Staff Writer
Monday, May 3, 2010; A08
NEW YORK -- Times Square is America's town square, the place where New Yorkers and visitors from around the country, and indeed the world, gather at times of triumph and tragedy. On election night 2008, people gathered here. They gathered, too, when Michael Jackson died. And, of course, they gather every New Year's Eve for the perennial ball drop.
The symbolism of Times Square -- the reason it draws people at history's memorable moments -- is also what has long made it a potential target for those who would do harm. "If you're going to make a terrorist statement, you want to do it on Broadway, you want to do it on the world stage," said Marc Eliot, a longtime area resident and author of a book on Times Square.
The explosives-laden vehicle parked at 45th Street and Broadway, on the first balmy night of the year, was aimed directly at America's pulsating heart, when the area was at its most packed, with restaurant-goers and theater-goers mingling with street musicians, panhandlers and tourists from around the globe.
And it was a testament to the national resilience that Times Square was packed again Sunday morning, just a few hours after the vehicle was disarmed and removed. The only visible signs of the close call the night before were the scores of police officers on the scene, including the white Technical Assistance Response Unit vans surveying the hours of video surveillance recordings from the cameras that are a ubiquitous staple of New York's post-Sept. 11 life.
Many knew they were coming to an area that was now considered a crime scene as well as the target of an aborted terrorist strike. But the response was a resolve not to easily surrender America's town square to an enemy unseen.
"This is what I do, and I'm going to try to keep on doing it," said Duane M. Jackson, one of the street vendors who first spotted the suspicious Nissan Pathfinder and alerted police nearby. He didn't make it home until 5 a.m. but was back on his corner by 8:30 a.m. "This is kind of the belly of the beast or whatever," he said. "But I'm just out here showing my colors.
"We dodged a bullet big time," he added, speaking as New Yorkers and tourists lined up to shake his hand, hug him and have their children pose for pictures with him.
Jackson knows a thing about dodging bullets. He was working as a vendor on Wall Street in Lower Manhattan on Sept. 11, 2001, and recalls vividly the planes hitting the World Trade Center towers. The photographs he snapped at the time show a chronology of that disaster -- people gathered around his car listening to news on the radio, the second plane hitting, people running for cover, then the ash debris covering the entire area, including Jackson's car.
Bertie Trager from Queens came up, threw her arms around Jackson and gave him a kiss. "This would have been an amazing atrocity," Trager said. "You saw it, you smelled it, and you immediately took action. You're a good New Yorker!"
Trager, a retired British Airways worker, was on Broadway with friends to catch a play and said they never considered canceling their plans, even with the latest incident. She said that bravado -- continuing a routine even knowing that this city is a prime terrorist target -- is what makes New Yorkers special.
"I'm a native New Yorker," she said with a shrug, as if that statement alone should explain it all. "What are you gonna do?" she said. "When you're a native New Yorker, we live our lives like this."
Mark Wolkoff, a native New Yorker transplanted to southern New Jersey, was on a weekend visit with his wife when they were caught on the wrong side of the barricades after dinner. They made it back to their 49th-floor hotel room to look down on the emptied Times Square.
"I've never seen Times Square closed," Wolkoff said. "It had a kind of end-of-the-world kind of feel."
But Wolkoff was out again Sunday, undeterred, and sanguine about how Times Square will possibly always remain a magnet and a target. "It's the center of everything -- good and bad," Wolkoff said. "If it's good, it's going to happen here. If it's bad, it's going to happen here."
Another regular visitor, Suzanne Behmke, a retired homemaker from outside Philadelphia, took the Bolt Bus up with her husband to catch "The Addams Family" musical on Broadway. The only difference in her routine was to arrive earlier in case there was extra security.
"I don't fear coming to New York," she said, recalling how she came up to show solidarity as soon as the theaters reopened after the Sept. 11. terrorist attacks. "I've never even had a bad experience in New York."
One worry is whether this attempt is the sign of something bigger, Eliot, the author said. In the case of the World Trade Center, a smaller attack in 1993 was a prelude to the more devastating attack of 2001.
"Because of what happened at the World Trade Center, a lot of this could be first-run, off-Broadway, to try to see if it works," Eliot said. For the terrorists, he said, the attitude is: "Hey, let's not play Podunk. You do it here, you're on a world stage."


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On free-responsive-templates.com i have strange things. Time by time i don't see category link in the footer and on the right area of blog. Also i dont see categories in admin panel. With categories all was ok when i started to work but now they are disappear:( Could you help please?
Hi sergeylandar,
I just checked your site and I can see the category links on the footer (3rd column). Can you site some instances which the category links disappear, or what browser you are using when the links disappear?
I updated wordpress, and now all looks ok. Thank you.
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text: Street Gourmet is well respected blogger and Chowhound about all thing Mexican and Latino in the LA area. In LA Mag's latest issue, he is featured in an LA taco crawl article. a number of LA Chow favorites are featured in a surprising well-informed artlcle about good Mexican food. For instance, the Mariscos Chente in Lennox is particularly featured.


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The relative contributions of vasoconstrictor and of dilator systems are balanced in health. The balance is reset in disease, often favoring a predominant role of vasoconstrictors, perhaps due to positive interactions between constrictor systems. For example, in hypertension, chronic high levels of angiotensin II (ANG II) stimulate the production of thromboxane (TxA2/PGH2) and/or isoprostane that activate constrictor thromboxane prostanoid (TP) receptors in the vasculature. The present study evaluated a modest concentration of ANG II administered acutely into the renal artery on urinary excretion of TxB2 and isoprostane and possible renal TP receptor activation that might amplify ANG II-induced renal vasoconstriction. TP receptors were blocked with SQ29548 coinfused with ANG II. Results were compared with a time control group of continuous ANG II infusion (40 ng·min−1·kg body wt−1) over 90 min. TP receptor antagonism during 30–60 min had no effect on the reduction in renal blood flow (RBF) produced by ANG II (15.8 ± 2.8 vs. 13.2 ± 4.9%) (P > 0.6). Likewise, there was no difference between groups during ANG II-induced renal vasoconstriction between 60–90 min in presence or absence of TP receptor antagonist (RBF −8.6 ± 4.0 vs. −9.6 ± 4.5%) (P > 0.8). Systemic arterial pressure was stable throughout, so RBF changes reflected localized changes in renal vascular resistance. Urinary excretion of TxB2 and isoprostane were nearly doubled by ANG II. The present data indicate that short-term intrarenal infusion of ANG II rapidly increases renal production of TxA2 but that the ANG II-induced renal vasoconstriction is independent of TP receptor activation during the initial 90 min of local challenge with ANG II.
- kidney
- renal circulation
- glomerular arterioles
- renin-angiotensin system
- prostanoids
- oxidative stress
- isoprostane
renal hemodynamic regulatory mechanisms play an important role in maintaining glomerular function, salt and water balance, and arterial pressure (AP). Renal vascular resistance (RVR) is controlled by a balance of vasoconstrictor and dilatory stimuli in health, with the vasoconstrictor agents predominating in many disease states. For example, in genetic hypertension in the spontaneously hypertensive rat (SHR), exaggerated renal vasoconstriction is seen in response to ANG II, a response primarily due to defective buffering of vasodilator prostanoids (12, 14, 24, 40). On the other hand, higher expression of a G protein-coupled receptor such as thromboxane prostanoid (TP) and vasopressin (V1) receptors can account for the ability of thromboxane A2 (TxA2) and vasopressin, respectively, to produce more pronounced renal vasoconstriction in young SHR (11, 13, 18, 48). In long-standing established hypertension, there are significant potentiating interactions among vasoconstrictor systems. In this regard, chronic increases in ANG II are known to stimulate production of TxA2/PGH2 with subsequent constriction-mediated TP receptors as well as angiotensin AT1 receptors. In ANG II-induced hypertension, ANG II increases urinary excretion of TxA2 and isoprostane that magnify the constrictor action of each other in the systemic and renal vasculature. After 2 wk of ANG II infusion, pharmacological inhibition of TxA2 synthesis or of TP receptors reduces a majority of the AP increase (34, 54, 55). A similar attenuated AP response to chronic ANG II is seen in TP receptor null mice (20, 28). Similarly, activation of TP receptors contributes to renal vasoconstriction in ANG II- and ANG II-salt-induced hypertension (33, 35). A similar systemic and renal interaction between ANG II and TP receptor activation is found in renovascular hypertension (6, 15, 23, 53). Such long-term interactions between ANG II and TxA2 appear to be involved in the exaggerated renal vasoconstriction resulting from tubuloglomerular feedback control of preglomerular vasomotor tone in SHR (7, 8).
Endogenous TxA2 is thought to exert considerably less influence on AP and RVR in health, at least under basal conditions. In normotensive animals, TxA2 levels are low and their tonic influence on basal renal and systemic hemodynamics is negligible. This conclusion is based on findings that inhibition of TxA2 synthesis or blockade of TP receptors has little influence on AP and/or renal blood flow (RBF) in healthy normotensive rats, especially when plasma ANG II is normal or low (21, 22, 31, 33, 35, 58). Also, basal levels of TxA2 contribute little to tubuloglomerular feedback-induced renal vasoconstriction in normotensive rats (7). Furthermore, basal RBF and RVR are in the normal range in TP receptor null mice (5).
Under resting conditions, the acute renal vasoconstrictor actions of ANG II are normally buffered, in part, by the vasodilatory prostanoids PGE2 and PGI2. This is evidenced by enhanced ANG II-induced constriction during inhibition of cyclooxygenase (COX) with indomethacin (2, 12, 19, 21, 27, 37). Longer-term ANG II infusion appears to recruit the vasoconstrictor prostanoid TxA2 and perhaps isoprostanes, both acting through the TP receptor.
The dose and duration of short-term ANG II administration required to stimulate TxA2 synthesis and recruit the vascular actions of TxA2 in the kidney are poorly defined. The literature on these acute actions of ANG II in normal animals is mixed. It seems clear that acute (<30 min) ANG II stimulation of isolated arteries/arterioles and glomeruli can lead to increased TxA2 synthesis. In vivo, ANG II infusion at a pressor dose (500 ng·kg−1·min−1 iv for 30 min) increases TxA2 urinary excretion (15, 54). Less ANG II infused systemically (50 ng·kg−1·min−1) results in more variable, nonsignificant responses of absolute TxA2 excretion (56). The extent to which renal excretion of TxA2 is dependent on an increase in systemic AP is not known.
Whether the increased renal synthesis of TxA2 immediately contributes to the renal vasoconstriction produced by acute ANG II in vivo is not clear. Some studies report that inhibition of TxA2 synthesis or TP receptor blockade blunts renal vasoconstriction produced by short-term administration of ANG II infused (10−9 to 10−6 M for 10 min) (9, 10) or injected (10−7 M) (17) into the renal artery of isolated kidneys perfused with artificial solutions. Similar TP-mediated renal vasoconstriction has been reported for intact kidneys in response to pressor doses of ANG II given intravenously (54, 58). Other studies, however, provide more equivocal evidence that does not support a definitive interaction between ANG II and TxA2 in renal hemodynamic responses to ANG II given (10–50 ng·kg−1·min−1 iv for 140 min) in the acute setting in normal animals (15, 33, 35, 56). To our knowledge, no in vivo studies to date have investigated the possibility of interactions during physiological conditions in which ANG II selectively increases RVR independently of changes in systemic AP. We have recently shown that immediate renal vasoconstriction produced by intrarenal administration of ANG II is mediated, in part, by NADPH oxidase and superoxide production (26). Possible acute involvement of isoprostanes was not evaluated.
To this end, the purpose of our present study is to determine whether intrarenal administration of ANG II for durations of 60–90 min at doses that reduce RBF 10–15% of baseline stimulate urinary excretion of the stable TxB2 metabolite of TxA2 and whether TP receptor antagonism attenuates ANG II-induced renal vasoconstriction. An important aspect of our in vivo studies is ANG II infusion directly into the renal artery of normotensive rats to evaluate primary local renal actions independently of any confounding systemic effects. We postulate that short-term ANG II challenge would stimulate TxA2 excretion that, in turn, would cause consistent, discernable renal vasoconstrictor effects when actions are restricted to the kidney and a preparation designed to provide highly reproducible results with minimal variability. TP receptors are antagonized by coinfusion of SQ29548 into the renal artery.
Sixteen experiments in all were performed using male Sprague-Dawley rats (6–8 wk of age) from the local breeding colony in accordance with institutional guidelines for the care and use of research animals. The animals were fed a standard lab chow with free access to tap water. They were deprived of food the night before an experiment.
The surgical preparation is standard for acute RBF experiments (4, 13, 25). Briefly, an animal was anesthetized by injection of pentobarbital sodium (65 mg/kg body wt ip) and placed on a heating table that maintained body temperature at 37°C. To ensure free breathing, a tracheostomy was performed and a PE-205 tube was inserted. For measurement of AP and collection of blood, the right femoral artery was cannulated. AP was measured via a pressure transducer (Statham P23B). The right femoral vein was cannulated with catheters (PE-10) for administration of maintenance solutions. Isotonic bovine serum albumin (4.7 g/dl) was infused initially at a rate of 50 μl/min to replace losses associated with surgery (1.25 ml/100 g body wt) and then at 10 μl/min for the duration of an experiment to maintain hematocrit at presurgical levels. A tapered and curved PE-10 catheter was introduced into the left femoral artery and advanced through the aorta until the tip was positioned ∼1 mm into the left renal artery. Placement of this catheter did not affect renal blood flow (RBF). A noncannulating flowprobe (1 RB; Transonic, Ithaca, NY) was placed around the left renal artery and filled with ultrasonic coupling gel (HR lubricating jelly; Carter-Wallace, New York, NY). The renal artery catheter was used for injection or infusion of ANG II, the TP receptor agonist U46619, or the TP receptor antagonist SQ29548 (Cayman Chemical, Ann Arbor, MI).
ANG II was infused into the renal artery at 40 ng·kg−1·min−1 for intervals of 60 or 90 min in three groups of animals. RBF and AP were recorded continuously, using conventional methodology (4, 13, 25). During the final 30 min of ANG II infusion in the two experimental groups, the TP receptor antagonist SQ29548 (180 ng·kg−1·min−1) was coinfused into the renal artery (ira). Reported values were averaged over the final 10 min of each period. No SQ29548 was given to the time control group.
Preliminary studies established that this dose of SQ29548 could reverse ongoing renal vasoconstriction induced by continuous infusion of U46619 into the renal artery. SQ29548 infusion ira for either 30- to 60- or 60- to 90-min was effective in abolishing the renal vasoconstrictor of the TxA2 mimetic. Moreover, the effect was rapidly apparent, within the initial few minutes of SQ infusion. Thus intrarenal administration of the TP receptor antagonist should have been effective if TP receptors were activated during ANG II infusion.
To ensure complete blockade of TP receptors, at the end of an experiment the TP receptor agonist U46619 (400 ng/10 μl) was injected into the renal artery. In each group of the ANG II infusion studies, the lack of RBF change in response to U46619 (400 ng/10 μl ira) challenge after each SQ29548 infusion period was confirmed; the results consistently indicated >95% blockade. The employed infusion of SQ29548 into the renal artery is similar to that infused intravenously to block the renal vasoconstriction and reduced GFR produced by intravenous infusion of the TP receptor agonist U46619 (56).
The ureter of the left kidney was cannulated with a PE-10 tube to collect urine during control and experimental periods. Urine was assayed for the stable thromboxane metabolite TxB2, prostacyclin (stable 6-keto-PGF1α), and isoprostane (8-isoprostane F2α) EIA Kits (Cayman Chemical).
Data are presented as means ± SE. Statistical analyses of the hemodynamic data groups were performed using one-way and two-way ANOVA for repeated measures within and between groups, respectively. Urinary excretion data were analyzed using a paired Student's t-test.
The average age of the rats was 7.0 ± 0.2 wk; body wt averaged 230 ± 11 g. The mean AP was 117 ± 3 mmHg, and RBF averaged 3.9 ± 0.2 ml·min−1·g kidney wt−1. Arterial blood hematocrit was stable: 45 ± 1% at the start and 45 ± 1% at the end of an experiment.
To verify effective, nearly complete SQ29548 blockade of TP receptors, the TxA2 agonist U 46619 (400 ng) was injected before (ira) and during SQ29548 infusion (180 ng·kg−1·min−1 ira) for 3 min. As is shown in Fig. 1, U46619 caused a maximum decrease in RBF of 22.8 ± 4.3% of baseline flow. Intrarenal infusion of SQ29548 did not change basal RBF or MAP, but it inhibited 97% the constrictor response to TP receptor stimulation by U46619 injection (0.8 ± 0.7% decrease in RBF, P < 0.001) (Fig. 1).
Infusion of ANG II ira (40 ng·kg−1·min−1) for 60 or 90 min reduced RBF and increased RVR, while MAP was unchanged in each group. The temporal changes in continuous recordings of RBF and MAP produced by ANG II before and during SQ29548 (180 ng·kg−1·min−1) are shown in Fig. 2. In the time control group, infusion of ANG II alone caused sustained renal vasoconstriction over the 90 min of observation as RBF was similar statistically as analyzed by ANOVA for repeated measures (P > 0.8). RBF was reduced at 30 and 60 min by 11.2 ± 3.6 and 13.2 ± 4.9% of basal RBF, respectively. MAP was stable at preinfusion levels at both time periods (1.5 ± 2.8 and −1.1 ± 3.5% changes, respectively). This degree of constriction was maintained over the 90-min period of recording.
SQ29548 was tested to determine whether ANG II led to renal vasoconstriction mediated by TP receptors. The RBF results analyzed by ANOVA for repeated measures within a group indicate that the ANG II-induced renal vasoconstriction was stable over time in all three groups of animals (P > 0.3–0.8). A major finding was that SQ29548 did not alter the degree of constriction produced by ANG II within either experimental group when infused during the 30- to 60-min time block (P > 0.3) or during the 60- to 90-min period of continued ANG II infusion (P > 0.8). The data in Fig. 3 clearly show that coinfusion of ANG II+SQ29548 between 30 and 60 min caused the same amount of renal vasoconstriction as did ANG II in time control studies. RBF was reduced by 15.8 ± 2.8% of baseline in this group (vs. −13.2% in time controls), indicating little effect of TP receptor antagonism under these conditions. Similarly, essentially the same RBF values were recorded when the TP receptor antagonist was infused between 60 and 90 min during longer-term ANG II infusion (−8.6 ± 4.0% RBF) compared with ANG II-induced constriction in the 60- to 90-min time control group (−9.6 ± 4.5% RBF). MAP was unchanged in all groups.
Urinary excretion of TxB2 and 6-keto-PGF1 was measured in the control period before ANG II infusion and then during 30–60 min of ANG II infusion in a paired manner. There was roughly a twofold increase in TxB2 excretion (253 ± 24 vs. 406 ± 48 pg/30 min, P < 0.005) while 6-keto-PGF1 (a nonenzymatic degradation product of PGI2) excretion was unchanged (P > 0.8) (Fig. 4). Renal excretion of isoprostane (8-isoprostane F2α) doubled (from 178 ± 33 to 379 ± 54 pg/30 min, P < 0.03).
The present study provides new information firmly establishing that the immediate renal vasoconstriction elicited by intrarenal infusion of ANG II, at a dose that selectively reduces RBF 10–15%, for 30–90 min, occurs independently of TP receptor activation and recruitment of the TxA2/PGH2 or isoprostane systems. This occurs at a time when ANG II stimulates renal synthesis and urinary excretion of TxB2 during the initial 30–60 min of intrarenal ANG II. The most likely explanation for this apparent paradox is that TxA2 synthesis takes place in the renal medulla or another site remote from the major resistance arterioles: afferent and efferent arterioles in the renal cortex. The decrease in RBF after 60 and 90 min of intrarenal infusion was similar in animals infused with ANG II alone or in combination with SQ29548. Although no hemodynamic participation a TP receptor agonist was unmasked, urinary excretion of TxB2 and isoprostane doubled, whereas urinary excretion of 6-keto-PGF1 was unchanged. These findings for acute experiments performed in normal animals indicate that renal hemodynamics are not influenced by TxA2 during intrarenal infusion of modest amounts of ANG II over a relatively short time period The present study is the first to demonstrate the lack of hemodynamic effects of TxA2 in vivo during acute intrarenal ANG II infusion.
The relationship between systemic infusion of ANG II and TxA2 effects has been studied for nearly two decades, with mixed results. Differences in results appear to depend on design of the studies, which includes the dose of ANG II, duration of administration, route of administration, and background activity of the renin-angiotensin system. Acute infusion of ANG II may or may not lead to increased renal production of TxA2 and/or TP-mediated renal vasoconstriction. All in vivo rat studies to date have been performed using iv infusion of ANG II that increases systemic AP, and the importance of extrarenal influences on renal responses has not been rigorously tested. High-dose iv infusion of ANG II (500 ng·kg−1·min−1 for 30 min) is reported to increase the excretion of prostanoids, with PGE2 and 6-keto-PGF1α increasing more than TxB2 (55). In these studies, ANG II increased AP 35 mmHg, a systemic effect that was reversed by ANG II receptor antagonism with saralasin, as was the case with urinary prostanoid excretion. The pressor response was reduced in part by the TP receptor antagonist SQ29548 given iv. In a subsequent study, a lower dose of ANG II given iv (50 ng·kg−1·min−1 for 45 min) increased AP 12 mmHg without significantly affecting RBF or GFR or urinary excretion of TxB2 (56). In this follow-up study, high-dose ANG II infused iv (500 ng·kg−1·min−1 for 45 min) increased AP 15 mmHg and reduced RBF ∼60%, responses that were not significantly attenuated by either TxA2 synthesis inhibition or TP receptor blockade. TxB2 excretion was apparently not measured in these animals. Other investigators report that, although the TxA2/TP system is quiescent during basal resting conditions, iv infusion of pressor amounts of ANG II (10 ng·kg−1·min−1 for 120 min) produces renal vasoconstriction, responses that could be reversed by systemic pharmacological inhibition of TxA2 synthesis or blockade or of TP receptors (3). In this regard, it would be of interest to evaluate intrarenal infusion of ANG II for durations beyond the tested 90 min in the current study.
We recently observed that systemic infusion of ANG II (50 ng·kg−1·min−1 for 30 min) reduced RBF to a similar degree in wild-type and TP receptor null mice, suggesting an acute renal action of ANG II independent of an endogenous TP receptor agonist (J. J. Boffa and W. J. Arendshorst, unpublished observations). Also, RBF and RVR are in the normal range in TP receptor null mice (5).
The elevated state of the renin-angiotensin system in chronic studies appears to recruit the potentiating constrictor role of TxA2 (or PGH2 or isoprostanes) in the regulation of renal hemodynamics. In studies assessing the role of TxA2 in renal vasoconstriction in hypertension, a consistent finding is that TxA2 and TP receptors have very little tonic influence on basal RBF and RVR in normotensive control rats (3, 22, 31, 33, 35, 43, 56). SQ29548 does not reduce the pressor response to iv injection of ANG II in conscious rats (34). However, when activity of the renin-angiotensin system is elevated in normal rats, TP receptor antagonism increases basal RBF without affecting systemic AP, suggesting a preferential action on the renal microvasculature (58). In contrast, TP receptors exert little control of RBF or RVR when endogenous ANG II levels are reduced acutely by angiotensin-converting enzyme inhibition. However, in rats pretreated with captopril and the plasma concentration of ANG II kept constant at elevated levels (5–80 ng/min iv for 90–180 min), administration of the TP receptor antagonist SQ29548 reduces renal vascular resistance and the pressor response to ANG II.
In our study, intrarenal infusion of SQ29548 for 30 min between 30 and 60 or 60 and 90 min of ANG II infusion did not modify the renal vascular response to such a short-term ANG II infusion. Our animals are likely in a euvolemic volume state in which plasma renin activity approximates that in conscious animals, considerably lower than normally seen in anesthetized rats not receiving a constant replacement solution of albumin that maintains plasma protein concentration and hematocrit at presurgical levels (13, 22, 49).
It is noteworthy that the 15-mmHg systemic pressor response to acute ET-1 iv infusion in rats is prevented by TP receptor blockade, whereas a concurrent ∼15% reduction of RBF is not significantly affected by SQ29548 (57). In another study, acute TP receptor antagonism did not affect ET-1-induced vasoconstriction for 30 min evidenced by a 15-mmHg increase in AP and a 40% reduction in RBF (36). Similar to our findings for ANG II in vivo, norepinephrine acutely increases prostanoid excretion (PGE2 > TxB2 > 6-keto-PGF1α), while the induced renal vasoconstriction of isolated perfused rat kidneys is unaffected by TP receptor blockade (30).
Ex vivo studies of isolated rat kidneys perfused with erythrocyte- and colloid-free saline solutions have employed administration of ANG II into the renal artery. Some reveal involvement of TP receptors, whereas others do not. In one study, acute injection of ANG II (100 ng) produces renal vasoconstriction that is potentiated by cyclooxygenase (COX) inhibition, indicating preferential synthesis of vasodilator prostanoids. The degree of ANG II-induced renal vasoconstriction was not influenced by the TP receptor blocker SQ29548 (15). Interestingly, as we observed in vivo, the lack of a functional contribution of TxA2 on TP receptors in the vasculature of their isolated kidneys was observed at a time when ANG II increased urinary excretion of TxB2, fourfold in their studies. Another laboratory reported that intrarenal injection of ANG II produces renal vasoconstriction of isolated kidneys that is not modified by SQ29548, at a concentration that inhibited constriction elicited by the TP receptor agonist U46619 (39). On the other hand, other studies of isolated kidneys perfused with artificial solutions find involvement of TP receptors when ANG II produces intense renal vasoconstriction. ANG II administration into isolated, perfused Wistar-Kyoto kidneys perfused with Krebs solution devoid of erythrocytes and colloid that produces near-maximum renal vasoconstriction is reported to be mediated in part by TP receptors (10). In the isolated rabbit kidney perfused with Krebs solution, intrarenal injection of ANG II (1–1,000 nM), but not norepinephrine, is reported to produce an increase in RVR that is attenuated by 20-min inhibition of TxA2 synthesis or TP receptors (17).
The role of the arachidonate/COX system has been studied in chronic experiments of different models of hypertension. Studies on the isolated, perfused kidney from an animal with renin-dependent hypertension induced by aortic coarctation show that the ANG II-induced increase in RVR is reversed by the COX inhibitor indomethacin, implying a COX metabolite is responsible for renal vasoconstriction in a chronic high-ANG II state (15). Furthermore, SQ29548 prevented the effect of ANG II in the hypertensive kidney, whereas no response was seen in the normotensive controls, indicating a more dominant role of a TP receptor agonist in long-term ANG II infusion studies. The findings indicate that the increased participation of TxA2/PGH2 and/or isoprostanes differ in chronic diseases associated with chronic stimulation of the renin-angiotensin system compared with control animals with minimal activation of the renin-angiotensin system.
In humans, acute ANG II infusion iv at a pressor dose that increases AP and decreases RBF stimulates renal production of prostanoids in the following descending order: PGF2α > PGE2 = PGI2 > TxA2 (29). Slightly different urinary excretion is seen in response to a similar pressor dose of norepinephrine (PGF2α > 6-keto-PGF1α > PGE2 = TxB2). In the rat, short-term ANG II infusion iv is reported to stimulate greater renal production of PGE2 in the medulla than the cortex (32).
Renal TP receptors have been localized to vascular smooth muscle cells of renal arteries and arterioles, glomeruli, and various tubular segments including proximal and distal convoluted tubules, thick ascending limb of Henle's loop, and collecting ducts (1, 47). Administration of a TP receptor agonist produces renal vasoconstriction by primarily increasing afferent arteriolar resistance (45). Similarly, exogenous 8-iso-prostane PGF2α preferentially constricts the afferent arteriole (46). It is possible that postglomerular production may not affect renal resistance arterioles acutely.
The source of TxA2 that is excreted in urine as TxB2 is not known. It may reflect a combination of filtered plasma and renal production. Urinary prostanoids probably mainly reflect renal synthesis (16). Our studies of increased urinary excretion of TxB2 and isoprostane during intrarenal infusion of ANG II in the absence of a change in systemic AP are consistent with this conclusion. In the mouse, ANG II infusion iv (150 pM·kg−1·min−1 for 120 min) increases AP and renal cortical and medullary production of the vasodilator prostanoids PGE2 and PGI2 predominantly via COX-2 (38). Based on location of mRNA for synthetic enzymes, PGE2 appears to be generated mainly by collecting duct cells, with production of PGI2 and TxA2 localized to the vasculature (51). In the dog renal artery, ANG II stimulates PGI2 production by the endothelium and PGE2 release from vascular smooth muscle cells (41). Normal rat glomeruli synthesize prostanoids acutely at different rates: PGF2α > PGE2 > PGI2 = TxA2 (42). Acute ANG II challenge leads to preferential stimulation of PGE2 by glomeruli. Under basal conditions, rat renal cortical tubules produce PGE2 > TxA2 > PGI2. Medullary tubules produce more prostanoids than cortical tubules (59). COX-1 and COX-2 are expressed in both the renal cortex and medulla. Renal medullary interstitial cells are rich in COX-2. ANG II stimulates renal cortical tubular cells to produce PGE2 > PGF2α and no PGI2, while vascular smooth muscle cells produce PGI2 (50). In terms of regional heterogeneity, it is interesting to note that the immediate contraction of isolated rabbit cortical afferent arterioles produced by ANG II is independent of TP receptor activation (52). On the other hand, TxA2 may be involved in acute responses of postglomerular outer medullary descending vasa recta (44). Changes in medullary perfusion may be small relative to total kidney blood flow.
In summary, the present study demonstrates that short-term intrarenal infusion of ANG II reduces RBF 10–15% over the initial 90 min of administration in the rat. ANG infusion into the renal artery rapidly increases renal production of TxA2 and urinary excretion of TxB2 and isoprostane, an index of oxidative stress. Nevertheless, the ANG II-induced renal vasoconstriction is unaffected by coinfusion of SQ 29548, indicating that renal vasomotor tone is independent of detectable TP receptor activation during the initial 90 min of local challenge with ANG II.
This work was supported by National Heart, Lung, and Blood Institute Grant HL-02334 and by The Western Norway Regional Health Authority.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Address for reprint requests and other correspondence: W. J. Arendshorst, Dept. of Cell and Molecular Physiology, 6341-B Medical Biomolecular Research Bldg., CB #7545, School of Medicine, Univ. of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7545 (e-mail: arends{at}med.unc.edu).
- Copyright © 2007 the American Physiological Society


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Border Games
If Israel rejects Hamas' terms for a cease-fire, then Cairo will consider unilaterally opening its border with the besieged Gaza Strip, Hamas spokesman Sami Abu Zuhri said yesterday.
In an interview with Al-Jazeera, Abu Zuhri said Hamas' proposal was drawn up with Egypt, which allegedly guaranteed it would be implemented. Whether Egypt actually made any such guarantees to Hamas over the cease-fire is of little importance. What matters is that Hamas made Cairo responsible for opening its border crossing with the Gaza Strip. If it fails to do so, Hamas may stage a storming of the border like the one that took place in January. If Egypt opens the border unilaterally, however, it will precipitate a crisis with Israel.
Hamas is banking on the Arab public coming to its aid in the event of a border breach. Yesterday speakers at a Hamas-organized protest in Gaza threatened to punch a hole through the re-erected fences.
To prevent a repeat of a border storming, Egypt is undertaking huge efforts to bring about a cease-fire. It has promised Israel it will enforce inspection of goods entering Gaza through the crossing, but will not allow the presence of any Israeli officials or surveillance equipment. After all its efforts, Cairo would consider Israel's rejection of the proposal a slap in the face.
Opening the border between Gaza and Egypt will allow Hamas to reestablish its standing in Gaza. In addition, it will also create a new balance of power in the region. Such a balance may not necessary work against Israel and Egypt, as it will also require Hamas to abide by the rules expected of governments.
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Commercial durability and strength. Improved head funneling for king pin to latch.
Patent pending king pin indicator is highly visible. NEW CAST JAW SYSTEM Double haw mechanism designed to be heavier for longer wear, with improved tolerances, eliminating chucking in jaw system.
Improved life and wear with added grease points. NEW PIVOT BEAM Incorporates a vibration isolator system for vertical and longitudinal vibration dampening and improved ride.
Wider mounting for better stability and reduced wear. Easier assembly of cast pivot beam to cross member.
Vertical height adjustment from 14S to 18S. Head and pivot beam can be offset 1S front or rear to maximize performance. SAE J2638 COMPLIANT
Based on heavy duty, accelerated life cycle criteria developed by SAE for fifth wheel and gooseneck. Fatigue and static tested to pass 9000,000 cycles. SIDEWINDER COMPATIBLE
Premium choice for short bed trucks


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Robbie Keane never backs down from a challenge and he proved that the infamous "ice bucket challenge" is no different.
Keane was challenged by former Galaxy player Mike Magee earlier last week to complete the challenge which has gained internet notoriety as a way to increase awareness for Amyotrophic Lateral Sclerosis (ALS) also known as Lou Gehrig's Disease. The Galaxy captain completed the task on Sunday as his wife Claudine soaked the Irishman with a bucket of ice water.
The video is below.
Post by Robbie Keane.


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Puzzle games that are addictive tend to get copied a lot. Such is the case of Tetris, and later another less-known (but also Russian developed) game called Shariki. Shariki was the original inspiration for what would eventually become Bejewelled, and thus an entire generation of what is collectively known as "match three" games was born.
Jewel Master: Cradle of Egypt 2 is another game in the Jewel Master series, of which over a quarter million games have been sold. Built upon the basics of a match-three game it does add some extra elements in to make things a little more exciting.
Producing a match turns these tiles into the "normal" colour. Once all of the tiles that are highlighted have been converted, you are able to proceed to the next level.
A slight twist in this game is that you are "building" Egypt and as such between levels you get a tile "slider" game, which can be skipped if you find it too frustrating and although it's a nice change of pace it doesn't really add that much to the game.
The "3D" portion amounts to nothing more than some still images, although it is still effective. It's completely irrelevant to the gameplay. Having said that, if you like Egyptian "elements" and music, you will definitely like the presentation of the game. In fact, if you have any of the previous games in the series this is really what amounts to an expansion package with no levels. There isn't much that is going to surprise you here, but then there isn't going to be much to disappoint you here, either.
It's hard to score a game like this. You either love this type of game or you don't. There's no multiplayer, only a couple of basic gameplay modes and 100 levels to get through. There are many similar games on other platforms for less money (or even free) but if this is your platform of choice this is just about as good as it gets. There's absolutely nothing wrong here, just nothing unexpected.
- Syd Bolton
The Good:
- Executes the match-three formula with good execution and a true Egyptian feel
- Introduces some extended elements beyond a standard match-three game
- Executes the match-three formula with good execution and a true Egyptian feel
- Introduces some extended elements beyond a standard match-three game
The Bad:
- Doesn't really add anything to the genre
- 3D elements, while present, are completely static
- Doesn't really add anything to the genre
- 3D elements, while present, are completely static
Score: 6.5 / 10
Syd Bolton surrounds himself in thousands of classic video games as Canada's top video game collector at the Personal Computer Museum (http://www.pcmuseum.ca) in Brantford, Ontario, Canada.


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Single junction circulators target cellular base stations
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Greensboro, N.C.RF Micro Devices has introduced five single junction circulators for wireless infrastructure applications.
The circulator product family includes the PC0882AG-21H, PC0940AG-21H, PC1843AG-21H, PC1960AG-21H and PC2140AG-21H. Each circulator delivers optimum electrical performance and rugged construction required by the demanding operational requirements of the high power, linear amplifier and transceiver sections of cellular base stations, repeaters and other forms of transmission equipment.
The single junction circulators are manufactured with samarium cobalt (SmCo) magnets packaged in aluminum housings, providing immediate improvements in reliability and performance vs. existing generations of circulators. The PCxxxAG-21H line of single junction circulators is specifically designed to cover the five major cellular frequency bands from 869MHz to 2170MHz, while exhibiting high intermodulation distortion (IMD) performance, low insertion loss and high isolation. All of the "drop-in" single junction circulators are offered in industry standard 1-in. x 1-in. packages for ease of implementation, and all are lead-free and RoHS compliant.
Pricing: $10.58 each in quantities of 1,000 units.
Availability: Sampling with volume shipments expected in the second quarter of this year.
Datasheets: PC0882AG-21H, PC0940AG-21H, PC1843AG-21H, PC1960AG-21H and PC2140AG-21H.
RF Micro Devices, www.rfmd.com