text:
Star Wars Coins Minted on South Pacific Island – And They're Real, Spendable Money
The force is strong with big spenders. Niue, a Pacific nation northeast of New Zealand has minted Star Wars coins adorned with images of classic characters from the trilogy including Luke Skywalker, Yoda, Darth Vader and Princess Leia.
Artist Brings Dead Trees Back to Life With Technicolor Paint Job
Artist Curtis Kilhorn is making it his mission to restore beauty to dead trees in the Colorado wilderness. Kilhorn paints their remains in a rainbow of bright colors, turning a dried-up tree skeleton into a technicolor conversation piece, and will install his creations in customers' backyards. He says the intention of the installations is to remind people "of the splendor of the world around us" but we think it's a righteous way to recycle. Mother Nature would be proud.
World's Biggest Connect-the-Dots Picture Makes a Real Masterpiece
Remember those connect-the-dot pictures from your childhood? Multiply that by about 6,000 and you get artist Thomas Pavitte's incredible new project that just might be the single most complex connect-the-dots image ever. Not only did he design the illustration, he connected the 6,293 dots himself. It took Pavitte nine hours to connect them all, revealing a legendary masterpiece as you've never seen it before.
Facebook Stamps Let You 'Like' and 'Dislike' Things in Real Life
For those who spend tons of time of Facebook, the real world can feel like a foreign place: How can you know if that cute girl at the bar is single without a relationship status? How to remember the name of that guy from high school if he hasn't been helpfully tagged? And how does one share an opinion on a clever magazine article or cool piece of art without a "like" button? Happily, liking things in real life just got a whole lot easier with Jailbreak Collective's set of Like/Dislike stamps.
Man Gets a Reverse Haircut in Clever Short [VIDEO]
A drastic haircut can be a traumatizing experience. But what if you could get your old look back in a snap?
Tom Offer Westort and his friend Peter Simon got inspired by Tom's decision to shear off all his head and facial hair and created this clever stop-motion video in which his extreme haircut is shown in reverse. Watch Tom go from totally bald and clean-shaven to his old shaggy-haired self in 30 seconds.
Trees Grown to Look Like People Are Way Creepy [PICTURES]
Depending on their surroundings, some trees grow abnormally, with their trunk and branches conforming to nearby debris or blockages.
Former jeweler Peter "Pook" Cook has perfected a process to replicate this himself and actually "sculpt" growing trees into specific formations. Cook began doing this in the late 80s, inspired by fig trees growing on a cliff face. It took him years to refine the method, but the Australian now turns trees into unnatural but indeniably cool shapes, including eerie, human-like figures.


text: I recently stumbled on this link and I was wondering what some of you more proffesional programmers thought about it. Which one is that is being used more. I remember a few years ago I would see tons of JAVA books on the shelves at the library now it seems like the honey moon is over. Just curious as to what you guys think on NOT which one is better, but which is being used more in the workplace and which would be more profitable - i guesss - to learn. So you can pimp yourself to an employer.

subset: commoncrawl


text:
Consensus four-star prospect Sheriron Jones committed Sunday to the Gators at the conclusion of his visit with the Gators.
Florida has landed an Elite 11 quarterback invitee for the second consecutive recruiting cycle.
Consensus four-star prospect Sheriron Jones committed Sunday to the Gators at the conclusion of his visit to UF, which included a workout in Saturday's summer camp session.
"I'm super excited," Jones said of his decision. "Just being around the coaches and everything, it was a great experience. The players were real great, too."
The 6-foot-2, 189-pounder attends Moreno Valley (Calif.) Rancho Verde, the same high school as former Florida linebacker Ronald Powell. Jones is the ninth member in Florida's 2015 class and will be the first prospect from California to sign with UF since Powell in 2010.
Jones chose the Gators over Tennessee and has no interest in any other schools.
"Not at all," he said. "I made my decision and I'm going to stick with it. It's a pretty good feeling right now. I can focus on getting this championship at my high school and finishing out my senior year.
"Next thing you know I'll be back in Florida, playing for the Florida Gators."
Before he chases a ring this fall, Jones will compete in the Elite 11 competition on ESPNU in early July at the Nike headquarters in Beaverton, Ore. He was invited Tuesday by former NFL player and current ESPN analyst Trent Dilfer, who coordinates the event.
It features 18 of the top high school quarterbacks in the nation. UF freshman Will Grier competed in the Elite 11 last summer and finished No. 3 in the final rankings.


text: Being many, many timezones away from Stockholm (and having been woefully behind in blogging in general) makes anything I have to say about the guilty verdict for the Piratebay admins rather old news, but I will just reiterate my previous prediction that nothing substantive will change in the P2P or filesharing world. Most likely appeals will prevent any change from affecting Piratebay itself for quite some time, but even if that proves mistaken, there is roughly zero chance that if the Piratebay disappears it would reduce the amount of Bittorrent traffic worldwide, much less decrease the amount of copyright infringement that occurs on the Internet. Just as with previous rightsholder victories (Napster, Suprnova, Isotorrent, etc.) there will likely be evolution in the way people share files, making whatever the next mainstream avenue of piracy (usenet, directdownload, etc.) that much harder for enforcement to have any real impact.


text:
What Color Is The Dress: The Day The Internet Went NutsA seemingly innocuous debate about the color of a dress has firmly divided the internet into two camps; blue and black or white and gold.
Internet Votes to #ExilePitbull In Walmart CampaignHow much do you want Pitbull to perform in your town, at the local Walmart? Probably not as much as the Internet want to send him to a remote corner of Alaska.
Smash Mouth Eats Eggs, No Longer "All Stars"


text:
|Número de publicación
|Tipo de publicación
|Número de solicitud
|Fecha de publicación
|7 Dic 1993
|Fecha de presentación
|18 Nov 1991
|Fecha de prioridad
|3 Ene 1983
|Número de publicación
|Alan S. Horn
|Cesionario original
|Whitby Research, Inc.
|Exportar cita
|BiBTeX, EndNote, RefMan
|Citas de patentes (6), Citada por (1), Clasificaciones (64), Eventos legales (7)
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet
This application is a continuation of application Ser. No. 07/438,357, filed Nov. 17, 1989, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 047,882 filed on May 8, 1987, now U.S. Pat. No. 4,882,352 which is a continuation-in-part of U.S. patent application Ser. Nos. 891,223 now abandoned and 891,262, now U.S. Pat. No. 4,743,618, both filed on Jul. 28, 1986, which applications are continuations-in-part of U.S. patent application Ser. No. 811,768, filed on Dec. 20, 1985, now U.S. Pat. No. 4,657,925, which is a continuation-in-part of U.S. patent application Ser. No. 640,685, filed on Aug. 13, 1984, now U.S. Pat. No. 4,564,628, which is a continuation-in-part of U.S. patent application Ser. No. 455,144, filed Jan. 3, 1983, and now abandoned. This patent application is also a continuation-in-part of U.S. patent application Ser. No. 839,976, which was filed on Mar. 17, 1986 now U.S. Pat. No. 4,722,933, which is a continuation-in-part of U.S. patent application Ser. No. 640,685, filed on Aug. 13, 1984, now U.S. Pat. No. 4,564,628, which is a continuation-in-part of U.S. patent application Ser. No. 455,144, filed Jan. 3, 1983, and now abandoned. All of the above applications are hereby incorporated by reference.
1. Field of the Invention
The invention relates generally to substituted 2-aminotetralins useful in treating schizophrenic disorders in humans.
2. Background of the Art
Schizophrenic disorders are mental disorders with a tendency toward chronicity which impairs functioning and which is characterized by psychotic symptoms involving disturbances of thinking, feeling and behavior. Some of the criteria for the diagnosis of a schizophrenic disorder are delusions, hallucinations, formal thought disorder and a deterioration from a previous level of functioning. schizophrenia specifically excludes organic mental disorders or mental retardation.
Schizophrenia has a worldwide distribution and a lifetime prevalence of 0.2 to 1% as found in studies of Asian and European populations. Higher rates are found in the U.S.A. and U.S.S.R., although the criteria used in these countries are often much broader. Schizophrenia becomes manifest in late adolescence or early adult life. Even with available forms of treatment, schizophrenic patients are said to occupy about half the hospital beds of the mentally ill and mentally retarded patients; and about 1/4 of all available hospital beds. Schizophrenia has been found to be found highly prevalent in lower socioeconomical classes which may be attributed to social disorganization and the resulting stresses; but, also there is evidence that this association arises partly because some patients, in a prepsychotic phase, drift down the social scale.
Although schizophrenia is thought to be caused by a complex of both inherited and environmental factors, approximately 10% of the relatives of schizophrenics will be recognized as schizophrenic. Thus, a genetic predisposition is probably necessary, if schizophrenia is to occur at all. The main treatments for schizophrenia are chemotherapeutic, in combination with the development of a therapeutic relationship with a skilled counselor, social support, rehabilitation and retraining. Accepted treatments for schizophrenia include the administration of neuroleptics such as haloperidol, chlorpromazine or thioridazine delivered parenterally or orally. The most widely accepted theory of the mode of action of these compounds is that they block dopamine receptor sites in the CNS (Seeman, Pharmacol. Rev. 32 229-313, 1980) . other drugs of choice for the biochemical therapy of schizophrenia include butyrophenones, thioxanthenes, dihydroindolones and dibenzoxazepines.
Recently, many patents have issued disclosing the use of different chemical entities for treatment of schizophrenia. For example, in U.S. Pat. No. 4,577,020 certain aminoalkyl and aminoalkenyl triazoles are disclosed as useful antipsychotic drugs. Un U.S. Pat. 4,588,721 a process for preventing the negative symptoms of schizophrenia is disclosed, which utilizes, as the active agent, a class of compounds which may be defined as benzodiazepines. U.S. Pat. No. 4,593,041 utilizes benzopyrone-type drugs for the treatment of schizophrenia. U.S. Pat. No. 4,626,549 suggests that certain 3-aryloxy-3-phenylpropyl-amines may be used in the treatment of schizophrenia. Finally, U.S. Pat. No. 4,620,977 discloses that certain N,N-dimethylated indolamines, are useful for the treatment of schizophrenia.
While there are many theories as to the neurochemical nature of the illness, it is thought by some researchers that schizophrenia results from a hyperactivity of dopamine-containing neurons in certain areas of the brain. Recently it has been suggested that a new approach to the treatment of schizophrenia could possibly be achieved by selectively stimulating dopamine autoreceptors (which control dopamine synthesis and release and are of the D2 type) rather than blocking postsynaptic dopamine receptors with the classical neuroleptics (Meltzer, Schiz. Bulln., 6 456-475, 1980). It has also been reasoned that this could lead to fewer CNS-related side effects.
In the case of two dopamine agonists, i.e. apomorphine and N-propylnorapomorphine, clinical studies have tended to support the above proposal (Tammings et al. , Science, 200 567 -568, 1978, Tammings et al. , Arch. Gen. Psy. 43, 398-402. Thus,, is this extensive interest in discovering new dopamine agonists which have a selective act4ion on dopamine autoreceptors. See also J. C. Van Oene et al., European Journal of Pharmacology, 87 (1983), pgs. 491-495 and J. C. Van Oene et al. , European Journal of Pharmacology, 102 (1984), pgs. 101-115 and Annual Reports in Medicinal Chemistry--20, Chapter 5, entitled "Dopamine Receptors and Dopaminergic Agents" by Schaus et al.
Thus, it is clear from the above that the search for chemical agents or drugs useful for the treatment of schizophrenia is continuing.
The present invention provides a method for treating the symptoms of schizophrenia which comprises administering to a schizophrenic an effective amount of a compound selected from the group consisting essentially of the group of stereoisomers or mixtures thereof of compounds represented by the general formula: ##STR4## wherein R1 is selected from the group consisting of pyridyl and ##STR5## X is oxygen or sulfur, Y, if present, is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12 carbon atoms, and a is an integer between zero and 3,
R2 is H, R4 is OA and R3 is selected f rom the group consisting of H and OA, A is H or is selected from the group consisting of hydrocarbyl radicals, or ##STR6##
R5 is selected from the group consisting of hydrocarbyl radicals and n is 2 or 3.
In the method of the present invention it is preferred that a is zero.
A is preferably H or is selected form the group consisting of phenyl and alkyl radicals having from 1 to 12 carbon atoms, and more preferably A is an alkyl radical having from 1 to 3 carbon atoms.
The more preferred groups represented by R1 are thienyl, phenyl, hydroxyphenyl, furanyl and naphthalenyl, e.g. 2-thienyl, 3-thienyl, 3-hydroxyphenyl, 4-hydroxyphenyl, etc.
Finally, it is even more preferred that the compound selected for use in the method of the present invention be an active compound capable of interacting selectively with presynaptic D2 dopamine receptors, e.g. in a human, without substantially activating postsynaptic receptors.
Compounds useful in the method of the present invention may be made by the methods disclosed in the above cited patent applications which are hereby incorporated by reference hereto. Particularly preferred compounds are as follows:
Compound wherein R1 is an organic radical comprising a fused ring wherein R1 is selected from the group of radicals represented by the general formulae: ##STR7## wherein Y is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, trifluoromethyl, halogen, acylamino, carboxamido, sulfonamide, hydrocarbyl and heteroatoms-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise form 1 to 12 carbon atoms and a is an integer of from 0 to 3. (R1 may be covalently bonded to the nitrogen atom, through --(CH2)n --, at any position on either of the fused rings.) More preferably, Y comprises no more than 5 carbon atoms and a is 0 or 1. Specific preferred compounds of this group include:
2-(N-n-propyl-N-2-[benzothienyl]ethylamino)-7-hydroxytetralin, and
Compounds wherein R1 is phenyl and/or substituted phenyl and is selected from the group of radicals represented by the general formula: ##STR8## wherein Y and a are as defined above. Specific preferred compounds of this group include:
2-(N-n-propyl-N-2-(4-hydroxyphenyllethylamino)-7-hydroxyteralin, and
Compounds wherein R1 is selected f rom the group consisting of radicals represented by the general formula: ##STR9## wherein X, Y and a are as defined above. Specific preferred compounds of this group include:
2-(N-n-propyl-N-2-[2-thienyl-4-bromo-5-methyl]ethylamino)-7 -hydroxytetralin,
2-(N-n-propyl-N-2-[3-benzothienyl]ethylamino)-7-hydroxytetralin and
This invention provides a method of treatment which comprises inducing a response at the D2 dopamine autoreceptors which control the synthesis and release of dopamine in the brain of a schizophrenic patient by administering a therapeutically effective amount of one of the foregoing compounds to the patient. In general, a pharmacologically-effective daily dose can be from 0.01 mg./kg. to 100 mg./kg. per day, and preferably from about 0.1 mg./kg. to 25 mg./kg. per day, bearing in mind, of course, that in selecting the appropriate dosage, in any specific case, consideration must be given to the patient's weight, general health, metabolism, age and other factors which influence response to the drug. A particularly preferred dose is 1.0 mg./kg. per day.
Another embodiment of this invention is the provision of pharmaceutical compositions in dosage unit form which comprise from about 2 mg. to 500 mg. of a compound of the above formula.
The pharmaceutical composition may be in a form suitable for oral use, for example, as tablets, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules, or syrups or elixirs. Compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents, flavoring agents, coloring agents, and preserving agents in order to provide a pharmaceutically elegant and palatable preparation. Tablets contain the active ingredient in admixture with non-toxic pharmaceutically acceptable excipients which are suitable for manufacture of tablets. These excipients may be, for example, inert diluents, for example calcium carbonate, sodium carbonate, lactose, calcium phosphate, or sodium phosphate; granulating and disintegrating agents, for example maize starch, or alginic acid; binding agents, for example starch, gelatine, or acacia; and lubricating agents, for example magnesium stearate, stearic acids, or talc. The tablets may be uncoated or they may be coated by known techniques to delay disintegration and adsorption in the gastrointestinal tract and thereby provide a sustained action over a longer period.
Formulations for oral use may also be presented as hard gelatine capsules wherein the active ingredient is mixed with an inert solid diluent, for example calcium carbonate, calcium phosphate, or kaolin, or as soft gelatine capsules wherein the active ingredient is mixed with an oil medium, for example arachis oil, liquid paraffin, or olive oil.
Aqueous suspensions contain the active compound in admixture with excipients suitable for the manufacture of aqueous suspensions. Such excipients are suspending agents, for example sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, sodium alginate, polyvinylpyrrolidone, gum tragacanth, and gum acacia; dispersing or wetting agents may be naturally-occurring phosphatides, for example lecithin, or condensation products of an alkylene oxide with fatty acids, for example polyoxethylene stearate, or condensation products of ethylene oxide with long chain aliphatic alcohols, for example heptadecethyleneoxycetanol, or condensation produces of ethylene oxide with partial esters derived from fatty acids and a hexitol, for example, polyoxyethylene sorbitol monooleate, or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides, for example polyoxyethylene sorbitan monooleate. The aqueous suspensions may also contain one or more preservatives, for example ethyl, n-propyl, or p-hydroxy benzoate, one or more coloring agents, one or more flavoring agents and one or more sweetening agents, such as sucrose, saccharin, or sodium or calcium cyclamate.
Dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent, suspending agent and one or more preservatives. Suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above. Additional excipients, for example, sweetening, flavoring and coloring agents may also be present.
Syrups and elixirs may be formulated with sweetening agents, for example glycerol, sorbitol or sucrose. Such formulations may also contain a demulcent, preservative, flavoring and coloring agents. The pharmaceutical compositions may be in the form of a sterile injectable preparation, for example as a sterile injectable aqueous suspension. This suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example, as a solution in 1,3-butane diol.
The pharmaceutical compositions may be tableted or otherwise formulated so that for every 100 parts by weight of the composition there are present between 5 and 95 parts by weight of the active ingredient. The dosage unit form will generally contain between about 1 mg. and about 100 mg. of the active ingredient of the formula stated above.
From the foregoing formulation discussion it is apparent that the compositions of this invention can be administered orally or parenterally. The term parenteral as used herein includes subcutaneous injection, intravenous, intramuscular, or intrasternal injection or fusion techniques. The compositions can also be administered transdermally with the use of an appropriate transdermal vehicle, as described in U.S. Pat. No. 4,405,616. The preferred vehicle is 1-n-dodecylazacycloheptan-2-one.
To illustrate the manner in which the invention may be carried out, the following examples are given. It is understood, however, that the examples are for the purpose of illustration and the invention is not to be regarded as limited to any of the specific materials or conditions therein.
Animal test models for either presynaptic or postsynaptic dopaminergic receptor function in the central nervous system were used to compare the effects of the (+) and (-) stereoisomers of 2-N-n-propyl-N-2-[2-thienyl]ethylamino)-5-hydroxytetralin (N-0437). It is believed that it is desirable for the treatment of schizophrenia, that the dopaminergic agent activate the presynaptic or auto receptors. (See for example, Tamminga et al., SCIENCE, Vol. 200, 5 May 1978 at pp. 567-8 and Meltzer et al., Psychopharmacology (1983) 81:37-41.)
γ-Butyrolactone (GBL), (8.7 mmol/kg, i.p.) induces a marked increase in dopamine synthesis in the striatum and olafactory tubercle of the rat brain. The ability of a drug to prevent the increased dopamine synthesis in this model is considered an index of drug's direct effect on presynaptic terminals of dopaminergic neurons (Walters, J. R. and Roth, R. H., 1976, Naunyn-Schmiedels Arch. Pharmacol., 296:5-14).
The method of Van der Weide et al (1986, Eur. J. Phzrmacology, 125:273-282) was used. Each test drug was administered, i.p. to 4-5 rats, five minutes prior to GBL injection. Dopamine synthesis in the straitum and olafactory tubercle was determined by measuring dihydroxyphenylalanine levels following decarboxylase inhibition with 3-hydroxybenzylhydrazine 2 HCl (0.47 mmol/kg, i.p.). Log dose--effect curves were used to calculate the ED50 and ED100, i.e. the dose which reverses the GBL effect by 50% or 100%, respectively. Results with (+) N-0437 and (-) N-0437 are given in Table 1.
TABLE 1______________________________________ Striatum Olefactory Tubercle ED.sub.50 (μmol/kg) ED.sub.100 (μmol/kg)______________________________________(+) N-0437 0.18 0.22(-) N-0437 0.13 0.20apomorphine 1.1 1.7______________________________________
Both steroisomers of N-0437 were similarly effective as agonists in this in vivo model for presynaptic dopamine receptors. Both were more potent than the reference dopamine agonist, apomorphine.
Inhibition of spontaneous locomotor activity in rodents by dopamine agonists is thought to be mediated via dopamine autoreceptors (Martin, G. E. and Bendesky, R. J., 1984, J. Pharmacol. Exp. Ther. 229:706-711).
The procedure used for this test was that of Hazelhoff, B. et al, 1986, Eur. J. Pharmacol 124:93-106. Drugs were injected i.p. into female Swiss mice, and five minutes later, the animals were placed into a rectangular activity case were locomotor activity was measured with a Automex motility meter.
The results with 10 μmol/kg of (+) N-0437 and (-) N-0437 and a racemic mixture of (±) N-0437 are given in Table 2.
TABLE 2______________________________________ Activity Counts/30 Min.______________________________________Control 2236 ± 93 (10)(+) N-0437 (Saline) 470 ± 74 (6)(-) N-0437 660 ± 82 (6)(±) N-0437 449 ± 82 (6)______________________________________
Both stereoisomers of N-0437 were similarly effective in the mouse locomotor activity model for dopamine autoreceptor activator.
Stereotyped behaviors such as continuous gnawing, biting, licking, are observed following stimulatio of postsynatic dopamine receptors. (Ernst, A. M., 1967, Psychopharmacologia, 10:316). The method of van der Weide, J. et al (1986, Eu. J. Pharmacol., 125:273-282) was used to assess the intensity of stereotyped behavior in male rate injected i.p. with either (-) N-0437 or (+) N-0437. (-) N-0437 produced a half maximal effect at 1.7 μmol/kg. However, (+) N-0437 was inactive in this test for postsynaptic dopamine receptor activity at doses up to 100 μg/kg.
Dopamine agonists produce contralateral circling behavior in rats which unilateral lesions of the substantia nigra which are made by prior injection of 6-hydroxy dopamine. The circling is thought to be mediated by stimulation of denervated supersensitive postsynaptic dopamine receptors (Marshall and Ungerstedt, 1977, Eur. J. Pharmacol., 41:361-367). The method of Van der Werf, et al (1984), Eur. J. Pharmacol. 102:387-399) was used. (-) N-0437, (+) N-0437 and (±) N-0437 (racemic mixture) were administered at a dose of 1 μmol/kg, i.p., and the animals were placed immediately into automated rotometers.
______________________________________ No. of turns/30 min.______________________________________(-) N-0437 278 ± 39 (4)(+) N-0437 0 ± 5 (4)(±) N-0437 171 ± 32 (4)______________________________________
(-) N-0437 showed significant activity in this postsynaptic dopamine receptor model while (+) N-0437 showed no effect.
In view of the above, it is clear that the presynaptic D2 dopamine receptors may be activated without appreciably activating postsynaptic dopamine receptors. This discovery may enable one to treat the symptoms of schizophrenia without causing the side effects associated with the interaction of the dopaminergic agent with the postsynaptic dopamine receptors.
While particular embodiments of the invention have been described, it will be understood, of course, that the invention is not limited thereto since many obvious modifications can be made and it is intended to include within this invention any such modifications as will fall within the scope of the appended claims. For example, this invention may be used to treat other diseases that are believed to involve an enhanced functioning of central dopaminergic neurons, e.g. Huntington's chorea, Tourette's syndrome and mania.
|Patente citada
|Fecha de presentación
|Fecha de publicación
|3 Ene 1982
|14 Ago 1984
|Nelson Research & Development Company
|Selective D-2 dopamine receptor agonist
|13 Ago 1984
|14 Ene 1986
|Nelson Research & Development Co.
|Substituted 2-aminotetralins
|20 Dic 1985
|14 Abr 1987
|Nelson Research & Development Co.
|Method and compositions for reducing the intraocular pressure of mammals
|17 Mar 1986
|2 Feb 1988
|Nelson Research & Development Co.
|Substituted 2-aminotetralins
|28 Jul 1986
|10 May 1988
|Nelson Research & Development Co.
|Substituted 2-aminotetralins
|8 May 1987
|21 Nov 1989
|Nelson Research & Development Co.
|Method for treating schizophrenia
|Patente citante
|Fecha de presentación
|Fecha de publicación
|31 Oct 2007
|12 Jun 2008
|Walter Muller
|Transdermal therapeutic system for treating parkinsonism
|Clasificación de EE.UU.
|514/438, 514/518, 514/399, 514/520, 514/415, 514/525, 514/418, 514/619, 514/443, 514/357, 514/517, 514/385, 514/523, 514/96, 514/519, 514/603, 514/521, 514/427, 514/95, 514/522, 514/657, 514/419, 514/649, 514/524, 514/471
|Clasificación internacional
|Clasificación cooperativa
|Clasificación europea
|24 Abr 1992
Owner name: WHITBY RESEARCH, INC., VIRGINIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:HORN, M.;HORN, S.;REEL/FRAME:006423/0867
Effective date: 19920219
|28 Oct 1994
Owner name: DISCOVERY THERAPEUTICS, INC., VIRGINIA
Free format text: MERGER;ASSIGNOR:WHITBY RESEARCH, INC.;REEL/FRAME:007183/0670
Effective date: 19940926
|15 Jul 1997
|Maintenance fee reminder mailed
|7 Dic 1997
|Lapse for failure to pay maintenance fees
|17 Feb 1998
|Expired due to failure to pay maintenance fee
Effective date: 19971210
|20 Jul 2005
Owner name: SCHWARZ PHARMA LIMITED, IRELAND
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ADERIS PHARMACEUTICALS, INC.;REEL/FRAME:016283/0716
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Owner name: SCHWARZ PHARMA LIMITED, IRELAND
Free format text: CORRECTIVE ASSIGNMENT TO CORRECT THE RECORD TO CORRECT WRONG PATENT NUMBER 5268358 ON AN ASSIGNMENTDOCUMENT PREVIOUSLY RECORDED ON REEL 016283 FRAME 0716;ASSIGNOR:ADERIS PHARMACEUTICALS, INC.;REEL/FRAME:016290/0105
Effective date: 20050623


text:
A proposed map on which a redistricting of Pima County Board of Supervisor boundaries would be based has been drawing considerable fire during recent public presentations.
At a Nov. 19 meeting in Oro Valley, it seemed no one knew where the map came from, how the rationale for proposed changes came about, whether the data on which the map is based are accurate, and why no alternative proposals were discussed by the five-member Pima County Redistricting Committee before it voted Nov. 9 to recommend the map to the Board of Supervisors for approval.
There were also questions as to whether, if the supervisors vote on the map as planned at its Dec. 4 meeting, such an action would be legal.
The proposed map would have Republican District 1 Supervisor Ann Day representing county residents in all of the Northwest between Interstate 10 and the Catalina Mountains and all of the Foothills from the Rillito River to the Coronado National Forest line. Day would lose voters in central Tucson, but pick up Catalina, Tortolita, all of Casas Adobes and the western portion of Marana.
Democratic District 2 Supervisor Dan Eckstrom would retain a portion of Sahuarita, lose some precincts in the southeast, but gain areas areas north and in central Tucson.
Sharon Bronson, Democratic Supervisor in District 3, would pick up more of north and central Tucson and the Tucson Mountains foothills and lose half of Marana, half of Casas Adobes and all of Catalina and Tortolita.
District 4 Republican Supervisor Ray Carroll would lose a handful of precincts in the East River and North Craycroft roads area but gain a larger portion of Sahuarita.
Raul Grijalva, Democratic Supervisor in District 5, would lose a portion of west Tucson in the Tucson Mountains and gain more of central and southwest Tucson.
In terms of population, Bronson would lose between 25,000 and 30,000 residents, Eckstrom would gain between 12,000 and 15,000, and Grijalva would gain about 20,000 to reach the desired 168,000 residents per district goal, based on recent estimates.
Tom Bowen, chairman of the Redistricting Committee, said he believes the Board of Supervisors will be violating state statutes if it votes on the map as planned.
Under state legislation, every county in Arizona was required to complete redistricting by no later than April, Bowen said. Pima County took the position that it couldn't be done by then and was able to get the deadline changed to Dec. 1, putting the supervisors at risk of violating the law with a Dec. 4 vote, he said.
The steering committee had been meeting for several months without any resolution of its goal to finalize a redistricting plan by the state's deadline date. After taking a break, the panel met again in August , but still was unable to come up with a redistricting map.
The panel was asked to examine alternatives, but refused, Bowen said, at which time he presented his map for consideration with the idea of minimizing the impact on voters in Pima County, equalizing populations, and establishing a starting point to to get the panel on track toward developing possible alternatives.
The panel refused to even consider his proposed map and the current map mysteriously appeared for the first time at the Nov. 9 Redistricting Committee meeting where it was approved on a 3-2 vote along party lines, Bowen said.
"The map was just sprung on us," said Supervisor Day. "I didn't like the process. There was no compromise, no give and take. It was not fair and was done behind closed doors. I guess that's politics."
Day said that while she is uncomfortable with the process as far as the proposed redistricting map, she's comfortable with its result because in taking away population south of River Road, it would make District One more solidly Republican and create a district very similar to her old Legislative District 12, which she represented in the state Senate for more than a decade.
Others at a recent meeting in Oro Valley loudly decried the Redistricting Committee process and its likely impact.
"It smells of gerrymandering," Peter Davis, Republican Legislative District 9 chairman, said.
Davis accused Bronson of "cherry picking" precincts to get rid of the Hispanic vote on the west side of Tucson and shifting those voters to Democratic Supervisor Raul Grijalva in District 5, and ridding herself of 7,000 Republican votes in the Sahuarita and Foothills area by having those voters distributed among Grijalva, Day and Eckstrom.
Davis said he had no idea of who drew up the map, but referred to whoever it was as "Bronson's re-election committee."
He said no member of the steering committee has yet to take credit for the map which simply appeared "from out of the blue" at a Redistricting Committee meeting the Friday before the Veteran's Day holiday.
If the proposed map is approved, Davis said, one rural district would be entirely eliminated and the county would be left with just one rural district and four urban districts.
"The rights of citizens are being violated to address the needs of the people responsible for the map," Davis said.
Davis and others also were angry that there were no representatives of the Redistricting Committee at the county election division's meeting in Oro Valley where the map was discussed.
"There was no one there on the Redistricting Committee to hear any suggestions for changes, so it looks like the map is going to go to the Board of Supervisors without any changes, " Davis said.
The redistricting committee is "operating under the color of law to appear legal" by having these meetings without any representation from the Redistricting Committee, he said, adding "the only way we'll get redress is to sue or go to the Justice Department. This is a slam dunk Democratic approach to redistricting."
Leslie Nixon, executive assistant to Supervisor Bronson, said the origins of the proposed map shouldn't be a surprise to anyone.
Nixon said the map was the product of deliberations involving her, Bronson and Linda Barter of Sahuarita, Bronson's appointee to the Redistricting Committee.
Nixon said that Bronson for the past year has been interested in a redistricting plan that would include rural representation in all districts, equalize populations and have the least impact on incumbents.
The map, Nixon said, is based on the idea of having approximately 168,000 residents in each of the five supervisor's districts, or about one-fifth of total county population, with a variance of no more than 2 percent from district to district, and rural representation by supervisors in all districts
Nixon said Redistricting Committee members were directed to bring in maps reflecting other proposals for boundary changes. Apparently only Bowen, Supervisor Carroll's appointee did. There was no explanation given either at the Nov. 19 meeting in Oro Valley or in subsequent interviews with supervisors or their representatives as to why the Bowen map received such short shrift.
Supervisor Eckstrom said he hadn't seen the proposed map as yet, but will be examining it as the date for its presentation to the Board of Supervisors draws closer. "It's too soon for me to cry," Eckstrom said, adding that he saw the current proposal as no more than a planning tool that may not end up as drawn.
Supervisor Grijalva could not be reached for comment.
Bowen is demanding that his map be introduced before the Board of Supervisors as a map of record. "This is an alternative solution and the public has a right to see it," he said.
Nixon suggested that the fuss over the map now being proposed stems from Supervisor Carroll's disappointment over the loss of precincts in the Craycroft-River roads area and said she was puzzled by Bowen's statement that he didn't know who the map was formulated by.
"Tom knows where it came from," Nixon said of Bowen.
Opponents of the proposed map allege that Bronson, in attempting to pick up Democratic votes in central Tucson and get rid of the Hispanic vote on the west side of Tucson, transferring that vote to Grijalva, appears to be trying to pack minorities into a few strongholds, thus maximizing the number of seats her party could win in the next election.
Another speaker at the Oro Valley meeting characterized the process as political "chicanery," manipulative gerrymandering reflective of the kind of power politics that allows politicians to take bond money away from one project approved by voters and shift it to another.
Barbara Hein, Legislative District 12 chairwoman, said that while she doesn't have the data to support her contention, "It appears as if the three Democratic supervisors have set up their districts in such a way that there will be no swing vote districts in the entire county so they will be able to maintain their Democratic majority on the board for the next 10 years."
Hein said the proposed redistricting map gives Bronson more urban votes, enhancing her strength and practically eliminating any need to campaign in rural areas of the district.
Hein said this creates a less competitive district and puts less pressure on Bronson to represent a broader mix of interests.
Bronson, who represents a 7,400 square-mile region stretching from Marana to the Mexican border, had a narrow victory in last year's primary election when she defeated Richard Pacheco, a retired state legislator and mining company supervisor, by 52 to 44 percent even though Pacheco was out of state for most of the campaign. She also narrowly beat Republican Barney Brenner by about 1,300 votes in the general election.
Many saw that as an indication of voter dissatisfaction.
Supervisor Carroll said the proposed redistricting format would shift nearly 7,000 Republican voters and about 1,000 Democrats out of Bronson's district, thereby strengthening Bronson's hold in the district in part by by packing other areas with Hispanic voters.
Carroll asked at the Oro Valley meeting whether county elections officials had done any analysis of the impact the proposed mapping would have so voters could weigh what was won or lost in the process. He was told such an analysis is currently being conducted.
He said he felt the map was done in haste, questioned estimates made related to that mapping and wondered why no one ever took the time to verify the numbers attached to the mapping.
Supervisors, for the most part , seemed not to be worried about voting on the map at a Dec. 4 meeting, three days after the deadline they were given, since that meeting will be their first in December.


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British author Scott Coren once described himself as a "militant atheist" who believed in a "world that operated on chance and natural selection" — but then something profoundly changed.
Coren, a father of two, said his path diverted after his daughter was born in 2012 with a serious heart condition.
He began caring for her around the clock, spending a plethora of time in medical facilities and a hospice, where he observed some dynamics that changed his heart and mind.
When Coren saw the nurses, whom he described as "human angels," caring for critically ill children, his views on God and the afterlife began to dramatically transform.
He found himself pondering death, in particular, thinking, "It can't be the end of things. It just doesn't make sense."
The "reason" and "logic" he had once used to deny God's existence were suddenly leading him toward a belief in something more profound.
Despite his best efforts to avoid becoming a Christian, Coren said that his reasoning faculties left him with no alternative option.
"The point of atheism as a belief is about logic and sense — and then you hit that juxtaposition," he said. "If you're using sense, then you can't deny when something else makes sense as well."
Coren said it was "a very gradual and slow process" that evolved over the last couple of years, but that his daughter's illness sparked an entire reworking of his views.
"My daughter was born with a heart problem. For two and a half years now I've been looking after her. She can't be left alone for her for a second," he explained. "My life is very much like a hermit. I'm awake all night, every single night. I'm living a very medicalized life."
His daughter's very serious condition means that she's sometimes abruptly hospitalized and can go from being well to falling into a life-threatening condition in just a half hour's time.
While some tend to blame God when loved ones experience illnesses, Coren has experienced quite the opposite, telling TheBlaze that his struggles have sparked an evangelical faith journey.
"I'm lucky because I have that Christian footprint behind me. I know the stories," he said. "One of the usual byproducts of being a militant atheist is knowing what you're militant against."
While Coren had a good command over the contents of the gospels before, though, he said he's now reading them through a very different lens: by viewing them as the word of God.
"It's almost rediscovering my own culture. I think God uses everything some way to reach somebody," he said, noting that he's spent his life ignoring signs and revelations. "There's actually a comfort in denying God, ironically, in having things objectively happen as a matter of chance."
As for his daughter, Coren said that she still needs surgery, but that her prognosis is positive.
And though he's been confined to his home and consumed with familial needs, the newfound Christian has found the time to pen a new book titled, "Matthew 13:44" — a literary project that is loosely based on his struggles surrounding his daughter's heart condition.
"It's a catharsis. It was a way of analyzing the experience I've been through," he said of the fictional story. "The skeleton is my story, but it's also a mystery, a bit of a thriller.
Coren said he wanted to focus in the text on how bad things sometimes happen in life — but that people can and often do find the strength to pick up the pieces and move forward.
Find out more about "Matthew 13:44" here.


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Hi there.
In 2004 I started to build a twi'lek costume.
I am Gamemaster of a Star Wars role playing game which is played by e-mail and one of my characters is a green twi'lek.
Some members and I planned to be on the Jedi Con 2004 in Düsseldorf/ Germany, so we thought it would be a great idea to build a costume about our game-characters.
This was when I had to build the twi'lek costume and I did it. (Didn't believe it until I actually wore it at the convention)
This is at the Jedi Con 2004. I wore the costume last weekend again and - as you might see at the picture - this time I changed the green make-up because the old one didn't match with the green of the lekku.
I will post some pictures from Sunday and some pictures of the process of building the costume soon.
Kindest regards from Germany and may the force be with you,


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One call took the rescuers to a local business. A fawn had entered the business, and they had to sedate it to remove it. Pennsylvania has an abundance of wildlife, and Pittsburgh is no exception.
Squirrel-Faced Girl seems to have become the person in Pittsburgh County who takes in stray animals. Word of her love for animals keeps spreading. One day she came home from working at Allegheny County Wild Lodge in Rockford and her son told her that someone at the Sewer Department had dropped off a loon in a box in the driveway. Off to Raccoon Zoo she went. Although several species of wildlife roam Pittsburg, only a few, such as raccoons and squirrels and rats are considered pest wildlife.
"They are the most wonderful, dedicated people I have ever met in my life. It can be 7 a.m. or midnight and they will always welcome in another animal," she says. Pennsylvania has many reptiles, and it's important to be able to identify Pittsburgh snake species and mammals.
Snake Woman The Woodchuck Guy points out that all animals that come in are brought in by a person, and people are delighted to see an animal helped or to help an animal themselves. "Animals bring out beautiful things in people," she said. Remember to treat the wild animals of Pittsburgh, Pennsylvania, with respect and care.


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Australian Cup runner-up Southern Speed gets a chance to again go head to head with Manighar in this weekend's prestigious 2012 BMW at Rosehill Gardens.
The four-year-old lost by a nose to the Manighar in the Australian Cup and finished fifth to the star import in the Ranvet Stakes two weeks ago.
Southern Speed has been in reasonable form this year, winning her first-up start and running second to Black Caviar in the CF Orr Stakes prior to the Australian Cup.
She has her work cut if she is to win the $2.25 million event this Saturday, having to overcome race-favourite Americain as well as Manighar.
She will be ridden by regular jockey Craig Williams on Saturday and will come from barrier two.
Horse Facts – Southern Speed
- Jockey: Craig Williams
- Trainer: Leon Macdonald and Andrew Gluyas
- Barrier: two
- Owners: B H Perks, Miss A M Clough, T J Robertson, Mrs E A Robertson, R B Fairclough and Mrs B D Fairclough
- Age: 4YO
- Gender: Mare
- Breeding: Southern Image out of Golden Eagle
- Career: 18 5-4-1
- Prize Money: $2,376,850
- Current BMW odds: $9.00 at bookmaker.com.au
Why Southern Speed Can Win the 2012 BMW
- She has been in good form in 2012
- She will be ridden by the experienced Craig Williams
- She is proven in big races, having won the 2011 Caulfield Cup and finished second in the Australian Cup
- She has won at 2400 metres before
Why Southern Speed Can't Win the 2012 BMW
- She has been unable to beat Manighar this year
- She is coming off a disappointing fifth in the Ranvet Stakes
- She is backing up two weeks after racing at a testing 2000 metres
Southern Speed is the current market mover at bookmaker.com.au who are offering the best odds on all the Rosehill action this weekend.
Sign up today as a new user quoting the code BONUSBET and you can take advantage of their massive $300 bonus bet offer!


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The first Saturday in May each year celebrates Free Comic Book Day, a day when when participating comic book shops around the world give away comic books absolutely FREE to anyone who enter their stores. With so many to choose from, just how do we know which ones are worth grabbing? We've compiled quite a long list of short reviews (includes a synopsis) of the majority the comics we can expect on offer come Saturday. While the majority of the comic books on offer are good, some stood out above the others.
V Wars (IDW)
A great Vampire thriller that takes place in a world where everyone is infected with the vampire virus, they are just unsure of when they will turn. Morals are tested, making monsters of men. Our protagonist is left questioning what it means to be human.
Rating: A+
Summer Blast (Kaboom)
This giant issue features a range of awesome titles crammed into one FCBD bumper issue. Featuring comics such as Adventure Time, Steven Universe, Regular Show, Peanuts, Garfield and a mystery comic; making for colourful artistic entertainment.
Rating: B+
Rocket Racoon/Ultimate Spider-Man (Marvel)
Marvel treats us to two visually strong stories. Rocket Raccoon boasts some great illustrations and action sequences. But whilst both Ultimate Spiderman and Rocket Raccoon are shown in full colour and feature great artwork, Rocket Raccoon is the more enjoyable of the two and it serves its purpose of introducing this character to a new generation.
Rating: A
Project Black Sky (Dark Horse)
This comic features both Captain Midnight and Brain Boy as they team up to fight a Giant Gorilla that has been infused with some rather advanced technology. The art on display in this issue is unbelievable and the best part is that readers will be getting this hard work for free! Most of the issue is in colour until the art shifts to show each step of the development process. Not only is this a great read but it also educates the reader about the hard work behind the scenes of a great comic.
Rating: A+
Free-For-All (Bongo Comics)
Bongo Comics offer a collection of Simpson's based comics that feature the people of Springfield, as well as the infamous Itchy and Scratchy. A definite favourite in this collection has to be the misadventures of Millhouse as he attempts to gain super-powers, asking Bart of all people for not only assistance but guidance. Each story has a little superhero theme at its core.
Rating: B+
The Adventures of Jellaby (Capstone)
This story is definitely one aimed at the kids. It tells the tale of Jellaby, a lost monster who befriends a human named Portia. This issue offers a few short stories, including a brief origin of the friendship between Jellaby and Portia. Each tale is filled with fun, imagination and youthful adventure. The art is great and really brings out the best in this colourful title.
Rating: B+
Hip Hop Family Tree (Fantagraphics)
I doubt we will be seeing this one on our shores in South Africa and it is actually a real pity. This comic focuses on the history behind some Hip Hop greats. This comic features the likes of Grand Master Flash, Kool Moe Dee, Afrika Bambaataa, LL Cool J and many more hip hop greats as it infuses the comic world with the truth behind Hip Hop culture. Although it may feature some cuss words, these are the days of good Hip Hop, when it was about talent and team-ups as artists worked together in order to create a new sound and a new movement. The art in this issue is great and the pages have been yellowed in order to give it that Old School feel.
Rating: A+
Transformers vs. G.I. Joe (IDW)
IDW offers a re-mastering of a classic cross over that features two of Hasbro's major franchises. The colours are bright and psychedelic, lending to the time period of its initial release. Fanboys of either of these franchises should definitely grab this issue as it will wake up those feelings of nostalgia for sure. Another reason to grab this issue is the fact that it shows you just why Snake Eyes has to wear a mask.
Rating: A
Guardians of the Galaxy (Marvel)
This issue is made of three parts, the first being an introduction to each team member of the Guardians of the Galaxy. Flash Thompson, aka Agent Venom, is approached by Tony Stark and offered a spot on the team of the Galactic Guardians. This leads to Flash Thompson and the reader being briefed on each team member and their motivation for what they do. This issue serves its purpose well as it brings readers up to speed with the team behind Marvel's next cinematic success. The second part of the story deals with another Galactic threat in the form of Thanos, as he attempts to reveal a little more about his character to the reader. The final section is known as "Staging Ground". It shows Spiderman in an adventure that happened decades ago at the Globe Theatre. The art and costumes are great in this offering as it shows us just what the Spider-Verse has to offer.
Rating: A+
All You Need Is Kill/ Terra Formars(VIZ)
Viz Media offers the reader two different tales, both with aliens at the center. "All You Need Is Kill" is a read that is receiving rave reviews at the moment. The protagonists are left fighting a threat that is constantly evolving…literally! This is a graphic novel adaption of this successful manga, so this is an English adaptation that is presented in full colour. Not too sure the purists will be too happy about this FCBD preview. "Terra Formars" still looks and reads like a Manga, it has been kept in the black and white tradition of Manga and the character designs suit what one would expect from the genre. It tells the tale of a group of astronauts as they travel to Mars but are taken by surprise when they discover that Mars is not exactly uninhabited. This issue offers a biography on each team member as well making it a worthy choice for FCBD 2014; it would have been an excellent choice had "All You Need Is Kill" been the Japanese version.
Rating: B
Maddy Kettle Book 1/Monster on the Hill (Topshelf)
Topshelf productions offers the FCBD crowd two titles crammed into a 26 pages issue. Maddy Kettlebook 1 features some great, highly detailed art in a tale that is mostly aimed at the kid crowd although it does feature some rather scary looking villains. The story looks dark using lots of black in the shading as well as dark inks in the colouring. Monster on the Hill is more of a colourful read that does not take itself too seriously. Monster on the hill features good art and colours however you cannot help but feel that Maddy is the main attraction in this one even though both scripts are not exactly memorable.
Rating: B
Les Miserables: The Fall of Fantine (Udon Manga Classic)
This 52 page issue gives the reader the Manga adaptation of a classic story… Les Miserables. The black and white art by TszMei Lee is amazing and really suits the story quite well. Victor Hugo's classic is done justice in this media as this issue proves that it is not a ploy to make an extra buck out of this classic tragedy. If you are looking for a classic retold in a fresh new way; this is definitely the comic for you on FCBD 2014.
Rating: A
Street Fighter #0 (Udon)
This issue collects three stories from the different street fighter titles currently on offer. The first story, "Hong Kong Hustle" features the likes of Ken Masters and Chun Li as they protect Ken's new apprentice from the dangers of a colourful and wonderfully presented Hong Kong. The second story, "Keep Your Enemies Closer" follows one of Street Fighters newest villains; Juri; as she attempts to find a way on to the winning team of villains now that M Bison has been defeated and possibly killed. Will Seth accept her assistance or will she be tossed aside and deemed unworthy? "Beyond the Hills" focuses on Akuma and is taken from the Akuma Origins Graphic Novel which was thoroughly enjoyable. The art in each page of this story is rather amazing as it allows the reader to understand just what lead to Akuma becoming one of the best characters of this very franchise. Having read the graphic novel, this sample is definitely a treat that will hopefully encourage you to do the same.
Rating: A
Atomic Robo, Bodie Troll and Haunted (Red 5 Comics)
Red 5 Comics gives us a 32 pager that shows all the projects that they have on offer for 2014. Each story on offer here is rather great and presented with some rather impressive illustrations. The story offered by each title serves its purpose well and that is to entertain and get new readership. Haunted is definitely the most impressive of the three and looks like an ongoing readers should be following.
Rating: A
Spongebob (United Plankton Pictures)
This comic is a collection of funnies that originate from the Spongebob TV show. So expect to see Spongebob, Patrick, Squidward, Mermaid Man and more. The comic also aims to educate as it teaches young readers about the habitats of sea creatures. A firm favourite here is also an educational short story as Spongebob attempts to teach Patrick about the magic behind the creation of comics. This is something that rings true to the industry and many familiar with it will have a good chuckle.
Rating: B
Fubar: The Ace of Spades (Alterna)
This comic is a military based zombie thriller, like Image's The Walking Dead; this entire issue is presented in black and white, the illustrations are strong and hyper violent, with zombies tearing through the flesh of the living. A group of American soldiers are tasked with retrieving Saddam from his headquarters in Iraq, all seems to go according to plan until Saddam proves he has an Ace up his sleeve and that a nuclear bomb was not exactly his weapon of mass destruction. This is definitely a title for the mature reader as it offers some explicit violence and swearing.
Rating: B+
SCAM: Crosswords (Epic)
This FCBD issue offers two stories that focus on characters of the Scam family. The first focuses on a mastermind named Crosswords; he is a man behind a mask that has made himself a millionaire thanks to his combination of genius and bloodlust. This story is ridiculously violent but it gets the point across; that you should not cross Crosswords! The second story shows Pint a Scam team member with a unique talent. The more he drinks the more powered up he gets. He is capable of feats that rival Superman; the only problem being that he is totally hammered when pulling them off. This story is rather entertaining and offers some humour as well. Both of these stories work well together and create an entertaining read.
Rating: A
Zombie Tramp/Ehmm Theory (Action Labs Danger Zone)
This issue comes with a "Mature Readers Only" warning for a reason, so make sure you do not get your 6 year old a copy of this, unless you like explanations. Zombie Tramp tells us of the origin of our protagonist Janey and what let her to be the Zombie entity that she is today. This issue manages to offer a great origin story within 10 pages. Ehmm Theory has always been a great read filled with humour, great art and colourful characters. The story on offer here deals with the concept of inter-dimensional time travelling as we meet a bad ass version of Gabe and Mr Whiskers as they warp into the current dimension that the story is taking place in. Both issues offer great stories filled with action of the violent nature!
Rating: A+
Skyward/Midnight Tiger (Action Lab Comics)
Skyward is definitely one of the front runners when it comes to Action Lab Comics, it offers a great fantasy story that feels like an RPG as you get to see the protagonist Quinn grow with each issue. The art in Skyward is top notch and this issue tells the story of why the Berserkers are a divided force and no longer unified in strength. The minute I saw this cover advertised by Action Labs I could not help but notice an interesting superhero. Midnight Tiger is set to be an ongoing title under the licence of Action Lab and this FCBD issue sees the hero creep onto the pages for his very first outing. This issue tells us exactly of his origin and how his costume came to be. Both comics on offer are brightly coloured and youthful. Well suited to the target audience and the protagonists alike. This issue also offers an interview with both of the comic creators as they answer those pending questions.
Rating: A
Steam Wars (Antartic Press)
Steam Wars is, as you guessed it, a steam-punk version of a Star Wars adventure… with anime flair to it. All the characters are based on characters from the Star Wars franchise. Only, dare I say it, the Steam Punk influenced art has made it more enjoyable than the usual Star Wars comics. The art is anime like and that is thanks to some great colouring and illustrations. I mean how awesome is it that the traditional lightsaber has been replaced by a Fencing Sword that has been infused with Electrical energy? Each character is given a refreshing new look and this really makes for a great, creative read even though it is based on a timeless classic.
Rating: A+
Mouse Guard (Archaia)
Mouse Guard is definitely a firm favourite amongst the Free Comic Book Day crowd. People gather at our venue each year looking to grab this title and now I finally understand why. This FCBD issue is amazing. The 48 page issue offers 6 different stories all crammed under the guise of Mouse Guard. Other titles include: Rust, Labyrinth, Bolivar, Will o' the Wisp and Farscape. The sheer talent on offer here will leave the reader in awe. Not only do you get a great short story but the illustration and colouring in each and every offering is highly detailed and impeccable! This is definitely a title that will fly off of the shelves once again at FCBD 2014!
Rating: A+
Scratch 9 (Hp)
Scratch 9 is definitely aimed at the younger kids, it is brightly coloured and not exactly thought provoking. It is more a sort of entertainment for younger readers to pick up and relate to after all the heroes and villains are animals you could find at your local pet store. While dealing with not so normal situations the protagonists are just ordinary pets and kids. Also on offer is Run and Amuk, however at the time of reading this review the second story on offer was still in its mock up stages. All we know right now is that Amuk was a pup that fell into the "Lake of the Sun" transforming him into a tough as nails, giant sized beast. Both stories are colourful and aim to capture the hearts and minds of the younger readership. I can only rate on what I have seen thus far, ` but this will not be a complex read due to its target.
Rating: B-
The Smurfs (Papercutz)
Papercutz make use of The Smurfs in order to grab the attention of readers at this year's FCBD. This issue will feature a number of short stories such as: The Annoying Orange, Dinosaurs and Ariol as well as The Smurfs. The art on display is so vast but one thing rings true throughout and that is the fact that the detail is great. The focus is not solely on entertainment either some stories aim to educate as well. This is a great read for younger viewers; filled with bright colouring and unique lettering, this is set to be a hit amongst the younger members in the crowd.
Rating: B
Sonic the Hedgehog/Mega Man Flipbook (Archie Comics)
At the time of receiving the review copies, Sonic was yet to be coloured and lettered, all that was able to be seen was the illustrations in their raw form. But this did not in any way steal from an enjoyable issue. The Mega Man comic was almost complete and this was definitely a strong title, featuring some great art and colouring. The Mega Man issue provided some great entertainment that aimed on furthering the protagonist of this major franchise. This issue focuses on the dawn of a new Mega Man, a man that is said to be Last son of Dr. Light, a man that has waited 100 years to be awoken…Mega Man X. Both issues possess great extras that explain the story thus far, but with Sonic lacking so much detail due to its pending completion I can only rate on what I have seen thus far.
Rating: B
Entropy (Epicentre Comics)
Entrophy tells the tale of a future where society is divided into two classes known as "The Haves" and "The Have Nots". The future is controlled by a government that destroys any opposition and any threat that might taint the minds of their modern society. But as you would expect, freedom is always something that is worth fighting for. The art in this issue is great; it is highly detailed and complements the complex script that is on offer. This issue is definitely for the mature reader, one that is able to cope with some explicit violence. This preview also contains two short stories: Vegetable and Crosses, both of which cater to the adult reader as well.
Rating: A
Epic (Comix Tribe)
Epic is a Zero Issue that aims to introduce a new, youthful superhero to the genre. Much like the protagonist the art aims to keep that youthful vigour as it offers bright colours and is not a story that is supposed to be taken too seriously. Featuring a colourful cast of villains' Epic makes for a witty read that does not pull any punches. This comic does a great job of showing us exactly how a teen would most likely react to the responsibility of superpowers.
Rating: B+
Ipso Facto (Automatic Pictures Comics)
This self-published sees its first print ready for Free Comic Book Day. It is great to see a title like this being shared amongst other titles on the free comic book shelves at this year's celebration. This first issue is all about an awakening. Mosel was just an ordinary teenager until he met a strange man that told him that he is destined for greatness. Not much is known about this strange man named Brezny but one thing is for certain, he knows about the future and that Mosel will need to save it. Featuring Johannesburg South Africa, this comic presents a mature title that presents a global threat. The script is great and offers good narration accompanied by a lot of cussing and explicit sexual references in this one, so this is not a title for fledglings.
Rating: B+
Courtney Crumrin (ONI Press)
Holly is the new girl in Hillsborough, being labelled an outsider was nothing new to her so she was used to the rejection she would face at her new school. Then during lunch she notices Courtney "Bad News" Crumrin. A girl labelled as being a witch, the current loner at the school. Intrigued by the fact that there is another like her, Holly attempts to befriend the cold Courtney Crumrin. After being ignored by Courtney, Holly gets up and leaves. After reaching out, she failed at another friendship, lost in isolation Holly takes a walk home, but little did she know that this walk would change her life forever. Courtney Crumrin is a great read for all ages, it boasts some great writing and some excellent illustrations and dark colouring. My only question is… where is Courtney's nose?
Rating: A
Uncle Scrooge: A Matter of Some Gravity (Fantagraphics)
Fantgraphics shares some stories featuring prominent ducks from the Disney family. This issue features two stories; one featuring Uncle Scrooge and his nephews and the other featuring Uncle Donald and his nephews. This issue is highly detailed and feels like classic Disney as they make use of classic colouring that does not look like it has been done digitally. Whilst the illustrations have great pencilling, the colouring feels rather bland especially in this day and age. Sure it is a classic read but it will not be winning new readers over, this will only please those readers that are looking for that nostalgic feeling.
Rating: B–
Buck Rogers (Hermes Press)
This is another Buck Rogers collection of short stories as Hermes Press reprints classics in order to give readers a taste of the past. Readers will be travelling back into time as they experience where it all started. Whilst most stories are re-issued prints, there is modern story on offer at the conclusion of this 32 page issue. Although the review copy was not 100 percent complete it is safe to say that this issue will be a hit amongst the readers that know what Buck Rogers is all about, young readers will most likely avoid this title as the art and colouring will look outdated to them.
The Intrinsic (Arcana)
Digitally rendered art can be a hit and a miss at times. Whilst this issue offers a great story and cast of characters, one cannot help but feel that this art has held the issue back, even if it is ever so slightly. The Intrinsic tells the story of a group of Philosophers. Philosophers are individuals, not necessarily human, that have been charged with protecting mankind from the supernatural. Philosophers are powerful magicians. The main character in this origin issue is Rex, he is called upon by the High Council of Philosophers. The story uses this as an opportunity to introduce the main cast of characters and set up the plot; as someone is trying to shut down The Intrinsic.
Rating: A-
Dumbest Idea Ever (Scholastic)
Scholastic gives us a youthful adventure that caters for all ages; Jimmy had it all he was the top of his class when it came to both sports and academics. He probably had the girls weak at the knees, but Jimmy's life was about to change thanks to all types of sicknesses. Jimmy missed the Basketball Championships, then he ended up missing school; his grades dropped almost as quickly as his popularity. How would Jimmy fix all of this and get his dream date…by creating a comic of course. There is something enjoyable about this read, from the illustrations to the lettering; everything works well together as it tells a story that is humorous and really relative to FCBD.
Rating: A
Showa (Drawn Quarterly)
This comic tells a Japanese classic and is set to be read right to left as it is presented in the traditional Japanese form. Shigeru Mizuki presents historical events in a fun light, this book offers lots of different styles of illustrating; all of which are in the traditional black and white Manga style. There are moments where the story makes a serious point ant the illustrations back it up, and then there are other times when the focus is on humour and once again the art gets the point across. Shigeru shows that he is able to intertwine Manga and realism and this creates a sheer work of art; a timeless classic!
Rating: A+
Finding Gossamyr (Th3rd World Studios)
I look at this cover and I immediately think of Disney's Frozen but do not be fooled by this cover as this story is unique in its own right. Only having been able to view ten pages thus far, it is safe to say that his is an adventure title that features some stellar colouring and illustration. Eloric wants to be more that what he seems destined to be. He no longer wants to farm and plough the lands in order to keep Wyrms happy. Eloric wants to be a Bladeslinger, the warriors of the land. But is Eloric worthy enough to wield the blade or is he too immature to handle that sort of responsibility? Only time will tell.
Rating: B+
The Tick (New England Comics Press)
This issue collects two stories one full length comic and one short story that is three pages long. As usual when it comes to this title, nothing is meant to be taken too seriously. The Tick comes to the rescue when superheroes like him end up being shrunk along with the city they have been sworn to protect. The issue is bright and colourful; definitely leaning towards getting newer, younger readers interested in this title.
Rating B+
In true 2000AD fashion, this issue is made up of a range of short stories. This 48 page issue has loads of different stories on offer, making it the gem of the FCBD titles this year. Stories come from a range of well-known titles such as: Rogue Trooper Anderson's Psi Division, Absalom, Slaine and Judge Dredd. Each story features its own team of illustrators so the reader is getting the best that the title has to offer. The art in Slaine is just amazing and it is definitely the best out of the bunch when it comes to this FCBD treat. This book will most definitely be one of the first to fly off the freebie desk this year, so make sure you grab it and prevent yourself from living with regret for the next year.
Rating A+
Find a Free Comic Store Locator here: http://www.freecomicbookday.com/storelocator
At the time of print, a small number of issues weren't available for review.


text:
MANHATTAN, Kan. - Denis Clemente scored 20 of his 24 points in a dominating first half and No. 13 Kansas State rode its stifling defense to a 88-65 rout over Texas A&M Tuesday.
Kansas State (14-2, 1-1 Big 12) quickly erased the memory of Saturday's struggle against Missouri with a resounding win in its conference home opener. The Wildcats jumped on Texas A&M early and kept the Aggies down with a harrassing defense to set a Bramlage Coliseum record with their 13th straight win - 10th this season.
Jamar Samuels had 19 points and Jacob Pullen added 15 for Kansas State, which held Texas A&M to 36 percent shooting.
Coming off a solid home win over Nebraska in its conference opener, Texas A&M (12-4, 1-1) faces a brutal week that opened with Kansas State and ends Saturday in Austin against new No. 1 Texas.
Ohio State 70,
No. 6Purdue 66
WEST LAFAYETTE, Ind. - Evan Turner scored 23 of his career-high 32 points in the second half, and Ohio State rallied from a 13-point deficit to beat No. 6 Purdue 70-66 on Tuesday night.
Turner scored 14 of Ohio State's final 18 points. He also had nine rebounds in his third game back since missing a month with a fracture in his back.
William Buford had 19 points and seven rebounds for the Buckeyes (12-5, 2-3 Big Ten), who were in danger of falling out of the conference race early.
Robbie Hummel scored 29 of his career-high 35 points in the first half for Purdue (14-2, 2-2). He tied a school-record with eight 3-pointers and had 10 rebounds.
E'Twaun Moore added 19 points for the Boilermakers, who lost their second straight after tying a school record with 14 straight wins to start the season. Purdue was coming off a 73-66 loss at Wisconsin on Saturday.
N.C. State 88,
No. 25 Florida State 81
TALLAHASSEE, Fla. - Scott Wood scored a career-high 31 points to lead North Carolina State to an upset of Florida State, spoiling the Atlantic Coast Conference home opener for the Seminoles.
The Wolfpack (12-5, 1-2 ACC) hit 11 of 23 3-pointers with Wood connecting on 7 of 11 attempts from behind the arc. Farnold Degand added 13 points and Julius Mays 12, including 10 straight free throws for the winners.
N.C. State rode an early 16-1 run to take a 23-12 lead as Florida State went 6:33 between field goals. The Wolfpack never trailed afterward.
Chris Singleton scored a career-high 22 points and Solomon Alabi added 15 for Florida State (13-4 1-2) which lost its second league game in three days.
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text:
Legal Question in Family Law in Texas
adopting niece and nephew from deadbeat mom
My sister in law is a deadbeat mom. She has 2 kids by a man who is being tried for murder. She herself was almost thrown in jail for drugs last week. She has no job and no way of paying the bills. Her gas and water have been turned off because she couldn't pay the bills. We would like to adopt the kids either temporarily while she gets her act together or permanently. We don't think she will consent but are afraid that if we call Child Protective Services they will be placed in an orphanage or in a foster home and we don't want that. We want them with us. What do we do?
2 Answers from Attorneys
Re: adopting niece and nephew from deadbeat mom
If you are in the Houston area, CPS is swamped and they gladly place children with responsible relatives.
Be advised to have your own attorney to represent your interests.
I would not sign anything until I had an attorney review it.
Best of luck to you!
Fran Brochstein
Re: adopting niece and nephew from deadbeat mom
CPS usually tries to keep kids within the family, particularly if someone wants them. Have you talked to CPS? You could discuss this with them for their ideas. CPS could be very valuable to you because they would investigate your claims and could help you obtain the custody or parental rights you want at little cost to you. If I were to do this, we would have to pay for the investigation as well as all of the legal work. If you want my assistance in this matter, please call me at 1-888-243-0560


text:
If you are among those looking for legitimate national championship tournaments in high school sports, there is good news and bad.
On the plus side, there has been and will continue to be conversation about the topic all the way up to the National Federation of High School Associations (NHFS), and through all 50 state associations. It is, after all, a dreamy, almost cinematic vision.
"It's something that sounds fantastic," said Michael Reddick, boys basketball coach at South Atlanta High, whose team has played on national television several times over the past few seasons. "You could make a lot of money."
Here's more news: The NFHS, comprised of high school athletics sanctioning bodies from all 50 states and the District of Columbia, has already voted to instruct staff to come up with a plan for national championships.
Now, the bad news: That vote was in 1979, never acted upon, and the idea has never come up for another vote. Also, although the topic of national championships is part of the NFHS's three-year strategic plan running from 2008-11, meaning it is to be officially discussed in that time, no serious inroads have been made.
Bob Kanaby, executive director of the NFHS, said the issue is not on the official agenda for the national summer meetings.
"As part of that strategic plan, developed by membership, they suggested that national championships be undertaken within that three-year period," Kanaby said. "That's what we will be beginning to do as we set out into 2009-10. It would start with the board, and the board will take something to membership. It could well be discussed this fall among sectional meetings, but those would just be preliminary discussions."
It will take a sea change in sentiment from state associations that comprise the NFHS to alter the landscape. Beyond the many financial and logistical hurdles, some major philosophies would have to change.
"It is not compatible with the mission of high school athletics," said John Johnson, director of communications and publications for the Michigan High School Athletic Association. "What is the essence of high school sports? To educate. It's about the time of day, and order of importance in the process.
"If we get too hung up on what our athletic teams do athletically as opposed to what our athletic programs do for our kids and do for our schools, then we're no better than the AAUs and other third parties which promote these things."
Many state associations forbid member schools from participating in any event that "purports" to be a national championship, risking penalties ranging from probation to suspension to the death penalty. That would be expulsion and the loss of rights to compete for state titles.
High school athletics was always intended to be one of the most democratic endeavors. Now we're starting to move toward a real elitist attitude where you try to get the best team possible.
--Ralph Swearngin, Georgia State Association executive director
"It's been a part of [informal] national federation discussions for 10 to 15 years," said Georgia High School Association executive director Ralph Swearngin. "The vast majority of states are very much opposed to it, and our executive committee is on record as being opposed. The process of a national championship is going to take kids out of school more -- much more -- and impact other sports."
Swearngin points out some of the obvious.
Think for a moment of all the clamor for correction to college football's BCS and how little progress has been made there.
Next, plunk your dreams into a box with the BCS, all the political nonsense that is by nature attached to the process of changing any large, long-standing system that has complex machinery (like the fact that many states have playing/officiating rules for each sport that differ from other states).
Making all the pieces fit would take some serious work.
"All state associations finish state playoffs at wildly different times," said Johnson, Michigan's spokesman. "Some basketball tournaments end in February, some at the end of March. What if some team out East had to wait five or six weeks for Michigan's state tournament to end?
"Even if everybody agreed that this was in the best interest of school sports, you couldn't coordinate every state to put together what would be a true national tournament. Think of states that have divisions of play based on enrollment. Which [schools] go? It's not necessarily a no-brainer; it's not always going to be biggest school. There are so many moving parts."
There are some national championships. In cheerleading, drill and dance, for example, there are televised competitions staged at Disney's Wide World of Sports in Orlando, Fla. But these are not sanctioned by the NFHS, nor by state members of the NFHS.
The national wrestling and weightlifting "championships" staged by the National High School Coaches Association (NHSCA) are invitational, and are not team competitions.
The NHSCA does not work in concert with the NFHS. There are also national high school rugby and surfing championships, to name a couple, that are not affiliated with the NFHS or its member associations.
Swearngin said Georgia permits student-athletes to compete in events like these and others as long as their high school coach does not coach, the athlete does not wear school uniforms or represent the school, and the school does not provide any funding or transportation.
Some states forbid participation in these activities altogether, and it is not uncommon for student-athletes from those states to participate anyway, as long as they are seniors and do not risk future eligibility. Last month, the first ESPN RISE National High School Invitational, a boys basketball tournament pitting national powers against one another, was held in North Bethesda, Md.
It was won by Findlay Prep, a Las Vegas-based collective of hoops studs from around the nation and beyond who attend class at Henderson International School in Vegas.
By its own billing it was an invitational tournament and not a national championship. The field was hand-picked, and some of the teams assembled rosters absent the governance typically associated with state associations.
ESPN RISE senior vice president James Brown said he "invited the [National] Federation [of High School Associations] to participate in our Invitational and welcome their involvement in the future."
Brown added that the ESPN RISE tournament was created to provide "high school athletes with opportunities to elevate and improve their talent."
If we get too hung up on what our athletic teams do athletically as opposed to what our athletic programs do for our kids and do for our schools, then we're no better than the AAUs and other third parties which promote these things.
--John Johnson, director of communications and publications, Michigan High School Athletic Association.
Swearngin, Georgia's executive director, was not swayed.
"What it's going go do is exacerbate a problem we already have; basketball high schools will be AAU all-star teams," he said. "I watched a little of the supposed national championship. There was a kid that had been in school two weeks; another a couple [of] months. It would create additional pressures.
"We have enough problems with Wheeler and Norcross [metro Atlanta schools that have dominated the big-school division in Georgia in recent years with several players who grew up outside their districts]. We have coaches and parents calling all the time, saying, 'Do something, do something.' "We can't, because if kids' parents move into the school district, they're eligible.
"High school athletics was always intended to be one of the most democratic endeavors. Everybody could participate, and we reward those who do the best. Now we're starting to move toward a real elitist attitude where you try to get the best team possible."
If, as South Atlanta coach Michael Reddick suggested, a national tournament could make money, that would be a good thing. It would have to, because it would take big money to run the thing. Unless funding was generous, how might some talented inner-city programs afford a trip across the country? Would that be a delimiter? No matter how good your team, you can't come unless you've got the cash? Bear in mind that many school systems are scrapping programs and cutting budgets these days just to function on a local level.
Unless somebody, like promoters and/or other funding parties step forward, national championships might not be financially feasible. Even if a bunch of cash showed up, the idea of national championships still clashes with the vision many state-level officials have for high school sports, and the potential logistics are enough to cause major headaches. How would even participants be determined?
Ignoring the fact that many states stage their state basketball tournaments at very different times, with different rules, Reddick proposed that states with multiple class systems based on school enrollment (Georgia has five, for example) could hold a mini-tournament between all the state basketball champs to determine a representative for regional play.
Those teams would feed into a national tournament. A national championship in football simply could not include participants from all 50 state associations and the District of Columbia. With a week between games, it would take too long to play down, and the impact on winter sports would be significant. Some states already play football to mid-December.
But for the sake of conversation, how would, say four or eight participants be determined? By some sort of BCS-like system?
"There has been no firm way [suggested] to determine who would qualify," Swearngin said. "Unless you had state and regionals that led to nationals, it's going to be a sham. If somebody randomly decided it's going to be these eight schools, if it were a media concoction, it's not going to work."
As Michigan's Johnson said, "There's no way anybody can see everybody play."
Despite potential problems, Bruce Howard, spokesman for the NFHSA, sees an attraction.
"Would the parents and the players in such a game think there was an upside? Perhaps," he said. "They might see a chance for exposure, for scholarships. But while there is an increase in televising of high school games, I'm not sure there's more of an interest from a casual high school fan than there ever was.
"The reason [national championships] keep being brought up are the entrepreneurs. There is a segment of those [among NFHS membership] who feel that since it is going on, we should try to be involved in it so it's done properly."
Montrose Christian (Rockville, Md.) coach Stu Vetter, whose team participated in the ESPN RISE tournament, said that ultimately the state associations and the NFHS will be forced to concede a national basketball championship.
"I think with this [ESPN RISE] tournament you are going to see every high school team in America wanting to be a part of this," said Vetter, who first debuted on ESPN with a high school hoops team back in 1987.
"If that happens, eventually a lot of the state associations, if not all, will yield to the pressure. It's not going to happen very quickly, but I see it happening."
Would a promoter with deep pockets help speed up the process?
"My only response would be I'm not in a position to give an answer," Kanaby said. "I'd say I'd be happy to discuss it with our board."
The subject has gone that far before, 30 years ago to be exact.
Despite concerns, the NFHS has already dipped its toes into the national tournament business.
In December, with T-Mobile as a sponsor, it will stage its third annual national invitational basketball tournament, featuring four boys' and four girls' teams. The first one was in Seattle in 2007, the second in Albuquerque, N.M., in '08. This year's location has not been announced. Forty-three states have approved it.
So the topic appears ripe to rise again, likely later this year. Kanaby has been poring through documentation of what happened in '79, when he was a principal in New Jersey, in search of background.
"Part of what we'll do is put together some of the points and discussions [from '79]," he said. "We'll share all that with the membership if it goes to that level. We'll try as best we can to re-construct the thinking that went into that discussion.
"It comes down to whether an overwhelming majority of the membership believes that the educational mission of high school sports can be further enhanced or developed through this platform. It would have to be much more than a one- or two-member majority."
Matt Winkeljohn recently left the Atlanta Journal-Constitution after spending 21 years there. He can be reached at email@example.com.


text: On Tue, 30 Sep 1997, Andreas Tille wrote: > On Tue, 30 Sep 1997, Marco Pistore wrote: > > > You should use libpng0 instead (the maintainer renamed the > > package since the major number of libpng is 0, not 1). > But this doesn't help when dpkg complains about missing libpng1 > when installing gimp. Ops, i wrongly argued you were the maintainer of gimp :) > Should I wait for a version with corrected > dependencies or follow the hint of Philippe Troin to use > libpng1 from bo? If you use libpng1 from bo then dpkg does not complain. However, programs compiled for libc6 that are linked with libc5-libraries (like libpng1 in bo) can produce segment faults; i'd suggest to upgrade to the new version of gimp only if you REALLY need it. Ciao, Marco -- TO UNSUBSCRIBE FROM THIS MAILING LIST: e-mail the word "unsubscribe" to firstname.lastname@example.com . Trouble? e-mail to firstname.lastname@example.com .


text:
Artist description:
Done in 1.5 hours... 80% ink left...too bad the cloak cant be seen in the thumb...Here's DARTH MAUL from STAR WARS.. Enjoy ^^
Flash Draw Created Mar 31, 2009 470 x 338px Unless noted Copyright 2009 renegadesoul.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
Wow looks hard!
wawwaw magnifiquo 5/5 this is star wars you are genius
I like it.
Wow that is actually awesome!! 5h
wow cool! and lol his nose looks real long XD
I love that movie 5/5
Omg its that dude from Starwars!? xDDD Awesome draw 8D! I alwas thougt he was mentally challenged in the movie xDDD great draw 5/5 -sk8
Brilliant 5 hearts & fav's
excellent job, Ren! 5/5
Wickedly fantastic!


text:
Yo beautifully displays recent orders on your site as little notifications to store visitors.
Yo beautifully displays recent orders on your site as little notifications and this accomplishes three powerful, conversion boosting benefits for your store:
1) Yo creates a busy and live atmosphere in your online store, much like the vibe you feel when you enter a busy retail store
2) Yo gives your store instant credibility and social proof from recent buyers, giving new potential customers the confidence to shop with you
3) The social proof and live atmosphere in your online store encourage more visitors to buy, resulting in increased conversion rates and revenue for you to continue growing your business and customer base!
Major Features
- Your visitors will see recent orders from real people in real-time, providing them with confidence to shop on your store
- Create a sense of community and engagement on your site
- Instantly increase your conversion rates with social proof! $$$
Example settings
Example Scenario of a website
- Display an order every – 30 seconds
- Only display the time stamp on orders within: The last 1 hour
- Loop and display orders within the last 2 weeks.
With these settings, a potential customer visits your website and every 30 seconds they'll see a display showing orders that were purchased within the last two weeks (without the time stamp). Only orders made within the last 1 hour will show the time stamp that it was purchased – for example 35 minutes ago, or 45 minutes ago, or 1 hour ago, etc.
Designed with You in Mind
- Take advantage of our super generous 14-day free trial to see if Yo is right for you
- Simple and easy to install in seconds – zero coding required
- Super light-weight so it doesn't slow down your site (or hurt your conversions and Google rankings)
- Beautifully designed and optimized for all devices: Desktops, Tablets, Mobile
We're Flexible – Customize it Your Way
- Customize your display message to show the first name, or keep it anonymous and write something like "Someone from Melbourne, Australia just purchased a T-Shirt"
- Edit the notification design to match your store
- Configure the timing of your notifications: set a delay before your notifications display and set the display duration.
- Choose the placement of your notification so it doesn't conflict with anything else
- Enable or disable the notifications on mobile
- Hide notifications from specific pages on your site.
- Hide specific products from displaying
- Hide specific orders from displaying
Required Plugins
WooCommerce by WooThemes – WooCommerce is a powerful, extendable eCommerce plugin that helps you sell anything. Beautifully.
- Live chat support
- Email support
This section describes how to install the plugin and get it working.
There are two ways to install Yo on your store
Automatic Installation
This is the easiest way to install the plugin.WordPress automatically handle all requests and do the installation for you.
You just need to follow simple steps
- Go to plugins in WordPress admin panel
- Click on Add New
- In search field type yo and click on 'Yo – Display Recent Sales in Real Time'.
- You will find 'Yo' plugin there with tagline 'Display Recent Sales in Real Time'.
- Click on install now
Manual Installation
- Download 'Yo – Display Recent Sales in Real Time' from WordPress directory
- You will find zip there with name
- Go To Plugins in WordPress admin panel and Click on Add New.
- Click on Upload Plugin and upload the zip file Or Extract the zip file and upload the
yopify_wc_yofolder to the
/wp-content/plugins/directory by FTP.
- Activate the plugin through the 'Plugins' menu in WordPress
You will find 'Yo' menu in your WordPress admin panel.Click on 'Yo', it will open settings page where you can customize the settings/notifications.
- What if I don't have many sales each day?
Yo is still perfect for your store, here is how it will work:
Time Stamp – Only recent orders will display a time stamp that says how long ago it was purchased. You have the flexibility to edit this so that only orders within the last 30 minutes, 1 hour, 5 hours, 12 hours or whatever you choose to display the time stamp
Keeping your store looking busy – You can set Yo to display orders from the past such from one or two weeks ago (you can edit this to whatever you like) to display, and orders within that period will display, just without the time stamp. This helps your store looking lively and busy with pop-ups displaying regularly (and they're genuine orders)
Time between orders displaying – You can set how often orders will show up (once every 10 seconds, every 30 seconds, etc)
Deferred Loading – Add an option in options table with label "yopify_yo_deferred_load" and value "true"
Very good
It does it's job very well. Please keep it up to date.
Lack of information and too expensive
Lack of information and too expensive. You can get similar plugin from codecanyon for $20.
Free only for 14 days 🙂
Free only for 14 days 🙂
Love to use yo for my store
Yo is best way to show live notification in real time. Customers can get attraction on other products and it helps to increase sale. It has very user friendly admin panel to customize notification styling, orders and products. Just want to say install it, feel it and love it.
Contributors & Developers
"Yo – Display Recent Sales in Real Time" is open source software. The following people have contributed to this plugin.Contributors
Translate "Yo – Display Recent Sales in Real Time" into your language.
Interested in development?
Browse the code, check out the SVN repository, or subscribe to the development log by RSS.
Initial Release
Major update
Update sync limit to 250 orders
Compatibility with WooCommerce 3+
Fixes progress bar
Add optional deferred loading option


text:
Hi folks,
I wonder if anyone has any thoughts on this:
How popular is Macbeth as a tragedy? If all the (37 ?) plays are compared for popularity, where would Macbeth come?
Also, if that play is popular, I wonder which other comes the closest to Macbeth.
In other words, which do you think are the two most popular Shakespeare plays?
hope this reads ok
The administrator has disabled public write access.
I would say Macbeth would have to be my most favourite shakespeare play as it has so many themes. A theme would be how ambition can lead to the unfolding of man's flaws in his character. It is also a characture of how women, in particular Lady Macbeth, will stop at nothing to ensure the best outcomes for themselves and their husbands, even if that means its necessary to kill not only the King of Scotland but many more subjects. In a way, I agree completly to how this play is a tragedy... with the revealing of mans character flaws.
The second best play by shakespeare would be Romeo and Juliet. Although it can be labelled as another tragedy I feel it is totally different to Macbeth. Macbeth is a comical tragedy while Romeo and Jukliet is a romantic tragedy.
well that's what I thought
The administrator has disabled public write access.