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Wallpaper Wednesday is one reason why we love our jobs. It gives us the ability to show off our friends and their skills, and it makes us feel good to share these things with you. So here is another gallery that we are honored to share, and heck, you can double click and drag these images to your desktop for a new screen saver too. —JH
For more Wallpaper treats click this LINK!


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I found this recipe years ago and it is the only one I will use. I tend to add a bit more garlic and less dill, but it is fine as is. Someone asked if they could substitute xantham gum for the saltines and I think that would be fine, although I do not know the substitution equivilant.
Hidden Valley Ranch Mix- Copycat
15 saltine crackers
2 C dry parsley flakes
1/2 C dry minced onion
2 T dill weed
1/4 C onion salt
1/4 C garlic salt
1/4 C onion powder
1/4 C garlic powder
Put crackers through blender on high until powdered. Add parsley, minced onion and dill weed. Blend again until powdered. Dump into bowl. Stir in onion salt, garlic salt, onion powder and garlic powder. Put into container with tight-fitting lid. Store dry mix at room temperature for 1 year. Makes 42 – 1 T servings.
To make dressing:
Add 1 T mix to 1 C mayonnaise and 1 C buttermilk. Mix well and chill before serving. For best results use full-fat mayonnaise and buttermilk. Makes 2 cups.

subset: commoncrawl


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Any Koreans in the House?
View Single Post
Habitual User
Join Date: Nov 2005
Posts: 633
BambooCactus- Just to clarify, i too am trying to learn more about modern korean culture and am honored when non-korean folk take interest as well, the thoughts i offered in my above post, weren't how i think, just a general mentality that i am aware of that exists among many koreans/minorities i know. I'm half korean, even though i can half way decently read, write, speak korean, i get serious hate from some koreans myself! I don't know what to say, i am sorry you have had bad experiences with koreans. i hope this doesn't affect how you view us on cosplay.com!!
we're not all that bad!!
ChaosButterfly- There was a manhwa thread a while back...it might give you some good information on korean manga! There was also a thread on hanboks, traditional, elaborate korean clothing. I think it's great you are interested in korean culture!
So let's discuss cosplay/convention related things pertaining to korea!
I have been trying to obtain more information on current cosplay/convention and such in korea, and have a little information, but not a lot. In terms of anime, Wonderful Days is a pretty good korean anime....i will have much more to report next spring on current korean conventions and cosplay, as this will be my next trip to Seoul, where i intend on participating in cosplaying at a convention...
The other korean folk on this site may be much more helpful in providing information on korean anime/cosplay/convention culture than me!
**there are many things that i can share with you on korean culture, but not related to this forum, so i guess pm me if you are interested**
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In Remembrance
Knox County — Instead of giving you a Christmas letter this year, I'd like to pay tribute to some people we lost during the past year. Many of these names existed in my own personal past. I'm sure that is true with you too. They will live on in their songs; they will live on in late-night movies. We will remember their accomplishments; their contributions to our world.
Before we begin, however, I'd like to pay tribute to those special babies who lost their lives in Newtown, along with the teachers who tried to save them. The last two precious ones were buried today. They were only famous in the way they died, but who knows what those little ones may have accomplished in their lives had they lived.
I truly believe they are safe in the arms of those wonderful teachers who tried to protect them and who also died as a result. They will protect them forever now.
Recently, my great-nephew, Nicholas, who is four I believe, and who lives in Connecticut not that far from Newtown, lost his precious dog, Noah. He told his mother he was going to ask Santa to bring him back for his Christmas present this year. I suspect that Noah, who has a biblical name we all know, a man who saved the animals two by two, was waiting for these little ones at the Rainbow Bridge when they passed into heaven.
Here are some of the more well-known people who passed away this year. Among them are Senators, entertainers, a Nobel Prize winner, a sports legend, authors, a chef, a famous mother, composers, astronauts, TV show hosts, a publisher, a reverend, directors, a film critic, a former Prime Minister, a hair stylist, a mobster, a TV producer, a screenwriter.
As I read their obits I noticed that many of them died of one form of cancer or another. If there is one disease, which has many forms, we should at last conquer its cancer. So many of our favorite people are taken by this health scourge. If you contribute to just one charity this year, make it for Cancer research. As a breast cancer survivor, I thank you.
Here is my list in no particular order:
Senator Daniel Inouye, of Hawaii. One of the longest serving members of Congress. He was a much decorated WWII veteran.
Ravi Shankar, sitarist popular in the 60s. I think the Beatles were associated with him.
Jenni Rivera, Spanish singer who died in a plane crash in New Mexico just recently.
Dave Brubeck, jazz pianist. I especially remember "Take Five." He died a day before his 92nd birthday.
Larry Hagman, of "Dallas" and "I Dream of Jeanie." Son of Mary Martin.
Art Ginsburg, TV chef known as "Mr. Food." He was 81.
Warren Rudman, Former senator, don't know where, at 82.
Etta James, soul singer
Teri Shields, mother of Brooke, at 79. I believe she suffered from Alzheimer's.
George McGovern, former senator. He took an anti-Vietnam war stance in 1972 in his presidential race against Nixon. I voted for him. He was 90.
Arlen Spector, former Senator from Pennsylvania, at 82.
Gary Collins, TV show host and also MC for Miss America pageant, at 74.
Arthur Sulzberger, publisher of the New York Times for 34 years, at 86.
Johnny Lewis, actor in "Sons of Anarchy." Found dead in a driveway. He was suspect in a murder case.
Andy Williams, crooner best known for his song from "Breakfast at Tiffany," "Moon River."
John Ingle, actor who played Edward Quartermaine on the soap, "General Hospital" for 430 episodes. He was 84.
Dorothy McGuire, singer in the 1950s-60s, at 85.
Michael Clark Duncan, played a death-row inmate in "The Green Mile." He was 54.
Rev. Sun Myung Moon, controversial Unification Church minister, who had millions of followers. I remember we called these worshippers "Moonies." I also remember that he married about 100 couples all at the same time.
Neil Armstrong, former astronaut who commanded Apollo 11 and who was the first man on the moon, at 82.
Phyllis Diller, comedian with a long career. She was 95.
Ron Palillo, actor who played Arnold Horshack on "Welcome Back Kotter," at 68.
Helen Gurley Brown, editor of Cosmopolitan, author of many books with a feminine slant. She helped usher in the sexual revolution. I saw her speak at a woman's conference in Connecticut in the 60s or 70s.
Al Freeman Jr., star of the movie, "Malcolm X, at 78.
Stuart Swanlund, guitarist for the Marshall Tucker Band, at 54.
Marvin Hamlisch, composer, at 68.
Judith Crist, well-known film critic.
Gore Vidal, author, at 86.
Tony Martin, Last of the big-name singer-actors of the Golden Age of Hollywood, at 98.
Chad Everett, actor, at 75.
Sherman Hemsley, star of the spin off from "All in the Family," the "Jeffersons," and later the TV show "Amen."
Sally Ride, astronaut, first woman in space, at 61.
Kitty Wells, Queen of Country Music, at 92.
Earl Scruggs, bluegrass legend/banjo pioneer, at 88.
Robin Gibb, member of the band Bee Gees, at 62.
Celeste Holm, one of my mother's favorite actresses, who won an Oscar, at 95.
Dick Clark, our favorite TV host of "Bandstand" and a many time MC of New Year's "Rockin' New Years Eve." He was 82. I did a special tribute blog to him this year.
Sage Stallone, son of Sylvester Stallone, at 36.
Maria Cole, wife of Nat King Cole, at 89.
Ernest Borgnine, actor, at 95. He and Lauren Bacall was an item.
Andy Griffith, everyone's favorite on TV, at 86.
Alan Poindexter, two-time shuttle astronaut. He died in a jet-ski accident at 50.
Yitzhak Shamir, former Israeli Prime Minister, at 96.
Vidal Sassoon, well known hair fashion hairstylist, at 84.
Adam Yanch, of the Beastie Boys, at 49.
Henry Hill, mobster, said to belong to the Lucchese crime family, at 69.
Frank Cady, known in the recurring role of storekeeper, Sam Drucker, in "Petticoat Junction," "The Beverly Hillbillies," and "Green Acres."
Bob Welch, was a member of Fleetwood Mac, at 66.
Ray Bradbury, one of my favorite Science-Fiction authors, at 91.
Herb Reed, last of the founding members of The Platters, at 83.
Richard Dawson, TV host actor, and comedian. He was host of "Family Feud," on the panel of the "Match Game" and also starred in the TV show, "Hogan's Heroes" which was based on the movie "Stalag 13," a prisoner-of-war camp in Germany during WWII.
Donna Summer, the "Queen of Disco." She was 63.
Whitney Houston, the diva of all divas in Pop music, at 48.
Chuck Brown, Godfather of Go Go, at 75.
Davy Jones, lead singer for the Monkees.
Nora Ephron, Academy Award nominee for screenplays for "When Harry Met Sally" and "Sleepless in Seattle," at 71.
A long list to be sure and there are names I left out. I wish everyone good health in 2013.
Merry Christmas and a Happy New Year!
NOTE: I didn't post all of the names that are given on the regular blog space. To see a complete list, go to www.southendstories.blogspot.com.


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Hi friends,
I don't know how to open, read and write to excel sheet with C code
Hi friends,
I don't know how to open, read and write to excel sheet with C code
Take a look at microsoft sites.
Learn C++ (C++ Books, C Books, FAQ, Forum Search)
Code painter latest version on sourceforge DOWNLOAD NOW!
Download FSB Data Integrity Tester.
Siavosh K C
Probably the same way that this other poster was after MS .DOC files
exactly as that thread said, there is a lot of additional formatting
involved with document types other than .txt, but i found that
you can write to an excel file just as you write to a text file, using
fprintf. your ability to control excel from within a C program is
fairly limited unless you learn how to program formatting info in
as well (which would be quite complex), but if you had a program
that needed to log outputs for some calculation, i found that you
can write to a spreadsheet - \n will move your destination cell to
the one below the current cell, \t will move it to the cell on the
right. this may be somewhat useful to you, but as far as reading
in from a spreadsheet in C, you're on your own
No No's:
fflush (stdin); gets (); void main ();
Example of fgets (); The FAQ, C/C++ Reference
My Gear:
OS - Windows XP
IDE - MS Visual C++ 2008 Express Edition
ASCII stupid question, get a stupid ANSI
I agree, given than excel can readily import tab or comma separated data from text files (I've done this many times), the amount of work it would take to generate a .xls file manually (without Microsoft's API) seems prohibitive.


text:
The following figure shows the directory structure of the Solaris 9 SPARC Platform Edition Languages CD.
The sol_9_lang_sparc directory contains the Solaris Web Start installer, which installs the Solaris language and locale software. The sol_9_lang_sparc directory contains these directories:
components – SimplifiedChinese, French, German, Italian, Japanese, Korean, Spanish, Swedish, TraditionalChinese, and TraditionalChineseHongKong locale packages and packages that are shared by all locales
Copyright – Copyright page
Installer – Solaris Web Start installer
Tools – The add_to_install_server script for creating a combined installation image
For more information on locale software, see International Language Environments Guide.


text:
Play free online games!
Dino Meat Hunt>
Dino Meat Hunt 2
Dino Meat Hunt 2
Play with your own profile by registering yourself for this fun game. You can also play as guest, but your scores and account will not be saved then.
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Dino Meat Hunt 2
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Score: 1 (1 votes)
DescriptionHelp these dinosaurs during the hunt for meat! They each have their own unique qualities, so try to use these to your advantage. Will you be able to finish this game on your own or would you rather get some help from a friend?
|Move (player 1)
|Jump (player 1)
|Move (player 2)
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text:
The purpose of this study was to determine whether there are alterations in the dihydropyridine and/or ryanodine receptors that might explain the excitation-contraction uncoupling associated with eccentric contraction-induced skeletal muscle injury. The left anterior crural muscles (i.e., tibialis anterior, extensor digitorum longus, and extensor hallucis longus) of mice were injured in vivo by 150 eccentric contractions. Peak isometric tetanic torque of the anterior crural muscles was reduced ∼45% immediately and 3 days after the eccentric contractions. Partial restoration of peak isometric tetanic and subtetanic forces of injured extensor digitorum longus muscles by 10 mM caffeine indicated the presence of excitation-contraction uncoupling. Scatchard analysis of [3H]ryanodine binding indicated that the number of ryanodine receptor binding sites was not altered immediately postinjury but decreased 16% 3 days later. Dihydropyridine receptor binding sites increased ∼20% immediately after and were elevated to the same extent 3 days after the injury protocol. Muscle injury did not alter the sensitivity of either receptor. These data suggest that a loss or altered sensitivity of the dihydropyridine and ryanodine receptors does not contribute to the excitation-contraction uncoupling immediately after contraction-induced muscle injury. We also concluded that the loss in ryanodine receptors 3 days after injury is not the primary cause of excitation-contraction uncoupling at that time.
- voltage sensor
- sarcoplasmic reticulum calcium release channel
- injury
the performance of high-force lengthening (i.e., eccentric) contractions is known to induce an immediate and protracted decrease in skeletal muscle strength in humans (6, 16) and laboratory animals (17, 19, 21-23, 33, 34). Although disruptions in force-generating and/or -transmitting structures contribute to the decrease in skeletal muscle strength after eccentric contractions (17, 32, 33), failure of the excitation-contraction (E-C) coupling process has been shown to be a primary mechanism responsible for the strength loss in mouse skeletal muscle (2, 19, 33, 36). Specifically, our laboratory (19) and others (2) have shown that cytosolic Ca2+ transients are reduced during electrical activation (i.e., tetanic contractions) but are unaffected during drug-induced activation (i.e., contractures) after (i.e., <3 days) eccentric contraction-induced injury in mouse skeletal mouse. On the basis of the relative changes in caffeine- and electrical stimulation-induced forces between injured and contralateral control muscles, we have estimated that E-C uncoupling accounts for ∼75% of the maximal strength loss immediately and 3 days after the injury in the mouse extensor digitorum longus (EDL) muscle (19, 33).
Although the exact mechanism of E-C coupling in skeletal muscle is not completely understood, it is known that the dihydropyridine and ryanodine receptors are critical to the integrity of E-C coupling and normal skeletal muscle function (9, 27). Morphological studies indicate that every other ryanodine receptor is physically linked to a cluster of four dihydropyridine receptors (9). It is hypothesized that voltage dependent activation of the dihydropyridine receptor proteins triggers sarcoplasmic reticulum (SR) Ca2+ release via directly linked ryanodine receptor channels (27). Presumably, activation of the directly linked ryanodine receptor then triggers adjacent unlinked ryanodine receptors, promoting further SR Ca2+ release. Alteration of subunits of either receptor is known to result in altered radiolabeled ligand receptor binding and E-C coupling failure (4, 9, 10, 13). For example, mouse skeletal muscle lacking the β1-subunit of the dihydropyridine receptor exhibits marked reductions in the maximum density of dihydropyridine receptor binding sites (Bmax), decreases in the affinity of the receptor for ligands (Kd), and reduced intracellular Ca2+ transients (30). In addition, ischemia, ischemic preconditioning, and ischemia-reperfusion are associated with reductions in ryanodine receptor Bmax and SR Ca2+ release in cardiac muscle (41, 42). On the basis of several experimental techniques (i.e., contracture, Ca2+ imaging, and electromyography), we have shown that the site of the exercise-induced E-C coupling failure is likely at or between the t tubule voltage sensor (i.e., dihydropyridine receptor) and SR Ca2+ release channel (i.e., ryanodine receptor) in mouse skeletal muscle (19, 33, 34). Despite the critical role of the dihydropyridine and ryanodine receptors in E-C coupling in vertebrate skeletal muscle, very little is known about how these receptors are affected by eccentric contraction-induced muscle injury. Therefore, the purpose of this study was to test the hypothesis that the performance of eccentric contractions in vivo would disrupt dihydropyridine and ryanodine receptor ligand binding characteristics (i.e., Bmax and Kd) in mouse tibialis anterior (TA) muscle immediately after and 3 days after eccentric contraction-induced injury, which would implicate dysfunction of these receptors in E-C uncoupling and the resulting strength deficits.
Animals. Female ICR mice (n = 32), 8-12 wk old, were used in the study. Their mean body mass was 31.6 ± 2.5 g (± SD). The mice were housed in groups of five or six animals per cage, supplied with food and water ad libitum, and maintained in a room at 20-22°C with a 12-h photoperiod. Mice were euthanized with an overdose of pentobarbital sodium. All animal care and use procedures were approved by the institutional animal care and use committee and met the guidelines set by the American Physiological Society.
Experimental design. Two studies were performed. In one study, 12 mice were used to evaluate the integrity of E-C coupling in EDL muscles immediately after (i.e., 0 days) and 3 days after the performance of 150 eccentric contractions in vivo. Force production of injured and contralateral control EDL muscles was measured during electrical stimulation with and without the presence of subcontracture concentrations of caffeine (i.e., 10 mM). Caffeine at this concentration acts directly on the SR to augment Ca2+ release during skeletal muscle activation (2, 15). Although this experimental approach has been used previously to demonstrate E-C uncoupling in mouse single muscle fibers after the performance of eccentric contractions in vitro (2), no studies have examined the effectiveness of subcontracture levels of caffeine at restoring the integrity of E-C coupling in isolated whole muscle after injury induction in vivo. It was hypothesized that 10 mM caffeine would significantly increase EDL muscle force production during twitch, subtetanic, and tetanic contractions.
In the other study, possible alterations in dihydropyridine and/or ryanodine receptors were evaluated in the TA muscles of 20 mice immediately and 3 days after performance of 150 eccentric contractions in vivo. These time points were selected on the basis of previous observations indicating that the contribution of E-C uncoupling to strength deficits are the greatest in the first 3 days after eccentric contraction-induced muscle injury (19). Changes in the number of receptor binding sites (Bmax) and affinity (Kd) were determined by using [3H]ryanodine and [3H]PN200-110 binding to the ryanodine and dihydropyridine receptors, respectively, in the muscles. The TA muscle was used instead of the EDL muscle because there was insufficient EDL muscle mass to reliably study receptor-binding characteristics. Although E-C uncoupling has not been studied as extensively in the mouse TA muscle as in the EDL muscle owing to methodological limitations (e.g., diffusion limitations), we believe that the two muscles share similar mechanisms (i.e., E-C uncoupling) of force loss after eccentric contraction-induced injury. For example, high-to-low stimulation frequency ratios are significantly elevated (68-297%) over the first week in the anterior crural muscles after injury (reanalysis of the data in Fig. 3A from Ref. 34), which have been used to indicate the presence of E-C uncoupling (8). This time course is similar to that for E-C uncoupling in the EDL muscle (19). Also, both muscles are almost exclusively fast-twitch (>95%) muscles (26; Warren GL, unpublished observations), exhibit similar functional deficits after the performance of 150 eccentric contractions in vivo and comparable recovery patterns (see Refs. 17, 19, 34), and experience similar reductions in myofibrillar protein content after injury (20). It was assumed that if eccentric contractions disrupted the dihydropyridine and/or ryanodine receptors, then receptor ligand binding characteristics (i.e., Bmax and Kd) should be altered in injured skeletal muscle.
In vivo muscle injury induction. The anterior crural muscles (TA, EDL, and extensor hallucis longus) from the left hindlimbs of mice were injured by use of 150 eccentric contractions as previously described (17, 19, 34). In this model, the TA muscle is responsible for nearly all (∼89%) of the torque measured (22). Briefly, the anesthetized (0.33 mg/kg fentanyl citrate, 16.7 mg/kg droperidol, and 5.0 mg/kg diazepam) mouse was placed on a temperature (39°C)-controlled platform with the left foot secured to an aluminum "shoe" that is attached to the shaft of the servomotor (Aurora Scientific 300B), and the left knee was secured by a clamp. Sterilized platinum needle electrodes (25 gauge) were inserted through aseptically prepared skin for stimulation of the common peroneal nerve. Torque output from the Aurora Scientific servomotor system was measured with the use of a Keithley-Metrabyte DAS 1802AO interface board, TestPoint dataacquisition/process-control software (version 4.0; Capital Equipment), and computer. To optimize anterior crural muscle torque output, voltage and electrode placement were adjusted during a series (<10) of isometric tetanic contractions (200-ms train of 0.1-ms pulses at 300 Hz). One minute after the last isometric tetanic contraction, the anterior crural muscles started the 150 eccentric-contraction (40° angular movement at 2,000°/s starting from a 20° dorsiflexed position) injury protocol. In general, the time between eccentric contractions was 10 s. Two minutes after the last eccentric contraction, an isometric tetanic contraction was performed. In the caffeine study, isometric torque as a function of stimulation frequency was measured immediately before and after injury induction, as well as 3 days after the injury. Isometric contractions (200-ms train of 0.1-ms pulses) were performed every 45 s at the following stimulation frequencies: 20, 40, 60, 80, 100, 125, 150, 200, 250, and 300 Hz.
In vitro mechanical analysis. In the caffeine study, injured and contralateral control EDL muscles were dissected free at 0 and 3 days postinjury and studied at 25°C by use of an in vitro preparation as previously described (17, 19, 32, 37). Briefly, after dissecting free the TA muscle, the anatomic resting muscle length (Lo) of the EDL muscle was measured with a micrometer by taking the average of the muscle's minimum and maximum in situ lengths. EDL muscles were then mounted in a chamber containing a Krebs-Ringer bicarbonate buffer (pH 7.4) with (in mM) 144 Na+, 126.5 Cl-, 6 K+, 1 Mg2+, 1 , 1 , 25 , 1.25 Ca2+, 0.17 leucine, 0.10 isoleucine, 0.20 valine, 10 glucose, and 10 μg/ml gentamicin sulfate and 0.10 U/ml insulin (the buffer was equilibrated with 95% O2-5% CO2 gas). The distal tendon was attached by silk suture and cyanoacrylate adhesive to a fixed support, and the proximal tendon was attached to the lever arm of a servomotor system. Muscle length in the chamber was set at its anatomic Lo by adjusting resting tension to 4.4 mN, a force previously determined to correspond to the anatomical Lo in mouse EDL muscle (32). Isometric twitch (Pt; 0.2 ms pulse at 150 V) and subtetanic (200 ms train at 100 Hz) and tetanic (Po; 200 ms trains of 0.2 ms pulses at 180 Hz) contractions were initiated at 7, 8, and 12 min into the incubation, respectively. After the measurement of Po, the EDL muscles were incubated in a Krebs-Ringer solution containing 10 mM caffeine for 5 min. Resting tension was measured during the caffeine incubation and remained unchanged. Pt, subtetanic, and Po contractions were initiated at 5, 6, and 8 min into the caffeine incubation, respectively. To compare EDL and TA muscle subtetanic contractile responses, it was determined that the 100-Hz stimulation frequency of the noninjured EDL muscle at 25°C is comparable to the 150-Hz stimulation frequency of the noninjured TA muscle in vivo, with both frequencies resulting in contractile forces that are 93% of the isometric tetanic force (or torque) value.
Muscle homogenization and total protein analysis. In the receptor binding study, TA muscles were used to characterize dihydropyridine and ryanodine receptor binding properties. Pilot studies indicated that individual EDL muscles were too small to give reliable receptor binding results. Because of similarities in fiber type and strength loss at 0 and 3 days between the TA and EDL muscles, it is assumed that the degree of E-C uncoupling is comparable in the two muscles at these times.
Either immediately after the in vivo torque measurements or 3 days later, mice were anesthetized with pentobarbital sodium (50-80 mg/kg), and the left and right TA muscles were dissected out, weighed, frozen in liquid nitrogen, and stored at -80°C. TA muscles were then homogenized on ice in 10 volumes of 100 mM NaCl, 50 mM MOPS (pH 7.4), 0.1 mM PMSF, 0.2 mM amino benzamidine, and 1 μg/ml each of aprotinin, leupeptin, and pepstatin A. Total protein was measured by use of the bicinchoninic acid protein assay (Pierce Chemical, Rockford, IL).
[3H]ryanodine and [3H]PN200-110 binding assays. Ryanodine and dihydropyridine receptor concentrations in injured and contralateral control TA muscles were determined with the use of two radioligands, [3H]ryanodine and [3H]PN200-110, respectively, by using protocols modified from those described previously (14, 29). TA muscle homogenate (1 mg/ml) was incubated with [3H]ryanodine for 16 h at room temperature in 300 mM NaCl, 50 mM MOPS (pH 7.4), 0.10 mM CaCl2, 0.10% 3-[(3-cholamidopropyl)dimethylamino]propanesulfonic acid, 0.10 mg/ml BSA, and 0.5-20 nM [3H]ryanodine (61.9 Ci/mmol). Nonspecific binding was determined in the presence of 10 μM of unlabeled ryanodine. Bound radioligand was separated from free radioligand by rapid filtration through Whatman GF/F filters. Each filter was washed five times with 3 ml of 300 mM NaCl, 20 mM MOPS (pH 7.4), and 0.10 mM CaCl2 and counted in 5 ml of Ultima Gold scintillant.
TA muscle homogenate (1 mg/ml) was incubated with [3H]PN200-110 in the dark for 2 h at room temperature in 50 mM MOPS (pH 7.4) and 0.2-10 nM [3H]PN200-110 (81.0 Ci/mmol). Nonspecific binding was determined in the presence of 1.0 μM nitrendipine. Bound radioligand was separated from free radioligand by rapid filtration through Whatman GF/F filters. Each filter was washed five times with 3 ml of ice-cold H2O and counted in 5 ml of Ultima Gold scintillant. Scatchard analyses were used to determine the Bmax and Kd of the ryanodine and dihydropyridine receptors.
Statistical analyses. Two-way ANOVAs with repeated measures were used to determine changes in ryanodine and dihydropyridine receptor Bmax and Kd, as well as in other variables (i.e., Lo, muscle wet weight and protein, force, torque). When significant differences were detected, Student-Newman-Keuls post hoc tests were applied. An α level of 0.05 was used for all statistical tests. Values presented in results are means ± SE.
Caffeine force potentiation study. The peak torque produced by the anterior crural muscles at the ankle during the first eccentric contraction was 6.59 ± 0.22 N·mm, or 218% of the torque during the preinjury maximal isometric tetanic contraction. The relative decrease in peak eccentric torque from the first to the last eccentric contraction was 40.3 ± 2.1%. Peak isometric torques produced as a function of stimulation frequency before and after the injury bout are shown in Fig. 1. Eccentric contractions caused significant reductions (48-88%) in isometric torques immediately after injury induction. Three days after injury induction, peak isometric torques were still significantly reduced from 45 to 68%. However, compared with torque values immediately after injury, isometric torques at stimulation frequencies below 250 Hz exhibited some recovery at 3 days postinjury, whereas isometric torques at stimulation frequencies above 200 Hz showed no significant recovery.
The mean wet weight of the contralateral control EDL muscles was 10.5 ± 0.2 mg. Wet weight of the injured EDL muscles was 6.4% greater than that of the control muscles. The resting length of the EDL muscles measured in the chamber (1.54 ± 0.01 cm) was not different from the anatomical Lo (1.55 ± 0.01 cm) measured in situ, as previously shown (31). However, resting Lo for the injured EDL muscles was 1.2% shorter than that for the contralateral control muscles.
The mean specific isometric tetanic force of the contralateral control EDL muscles was 27.0 ± 0.5 N/cm2. The performance of eccentric contractions in vivo caused significant reductions in EDL muscle force production measured in vitro (Fig. 2). Compared with contralateral control muscles, peak tetanic, subtetanic, and twitch forces were all significantly reduced in EDL muscles immediately after performance of eccentric contractions (-52, -60, and -65%, respectively), and these force values were unchanged at 3 days (-45, -55, and -60, respectively). Exposing injured EDL muscles to 10 mM caffeine caused significant increases in peak force during tetanic (13-35%), subtetanic (30-59%), and twitch (76-84%) contractions immediately and 3 days after injury (Fig. 2). However, force production during tetanic and subtetanic contractions was unaffected by 10 mM caffeine in control muscles (Fig. 2). As expected, force production during twitch contractions was significantly potentiated (48-62%) by 10 mM caffeine in control muscles (Fig. 2). The ability of caffeine to significantly increase Po in injured EDL muscles further supports our previous observation that E-C coupling failure contributes to the strength loss immediately and 3 days after the performance of eccentric contractions (19).
Receptor binding characteristics study. The peak torque produced by the anterior crural muscles at the ankle during the first eccentric contraction equaled 6.33 ± 0.17 N·mm, or 191% of the torque during the preinjury isometric contraction. The relative decrease in peak eccentric torque from the first to the last eccentric contraction was 44.8 ± 0.8%. The peak torque during the preinjury isometric tetanic contraction averaged 3.32 ± 0.10 N·mm. The peak torque during the postinjury isometric tetanic contraction was reduced 45.3 ± 1.3%.
Unlike the EDL muscle, there were no significant differences in wet weight between the injured (60.7 ± 1.1 mg) and contralateral control (59.3 ± 1.1 mg) TA muscles. However, total protein content in the injured TA muscles (10.9 ± 0.5 mg) was 10% less than in the contralateral control muscles (12.1 ± 0.5 mg) 3 days after injury induction.
Representative Scatchard analyses of ligand binding of [3H]ryanodine and [3H]PN200-110 to the ryanodine and dihydropyridine receptors, respectively, in injured and control TA muscles 3 days after injury are shown in Fig. 3. The mean and range of the correlation coefficients for [3H]ryanodine binding were 0.986 and 0.941-0.999, respectively. The mean and range of the correlation coefficients for [3H]PN200-110 binding were 0.978 and 0.904-0.999, respectively. The Bmax for [3H]ryanodine binding relative to muscle wet weight was unchanged immediately after injury but was reduced 13% 3 days after performance of eccentric contractions in the injured TA muscles compared with contralateral control muscles (Table 1). Because there are no differences in wet weight between injured and contralateral control TA muscles, the reduction in Bmax (expressed relative to wet weight) at 3 days reflects a decrease in the absolute number of ryanodine binding sites in the injured muscle. When Bmax for [3H]ryanodine binding was expressed relative to protein content, there were no differences between injured and contralateral control TA muscles, indicating that there was no preferential loss of the ryanodine receptor with the decrease in total protein content in injured TA muscle 3 days after injury. The Bmax for [3H]ryanodine binding expressed relative to protein content at 3 days was lower than values immediately after injury induction in both control and injured muscles (Table 1). Likewise, the Kd of [3H]ryanodine binding was not different between injured and contralateral control TA muscles, but 3-day values were lower than values immediately after injury induction in both control and injured muscles (Table 1). The reason for the difference in the affinity of [3H]ryanodine binding to the SR release channel between these two points is unknown. It is possible that differences in the drugs used to anesthetize mice (see materials and methods between these time points may have influenced the sensitivity of ligand binding. Certain anesthetics are known to impair skeletal force production (18), as well as ligand-binding characteristics (11, 12).
In contrast with the [3H]ryanodine binding, the Bmax for [3H]PN200-110 binding relative to muscle wet weight and protein content was increased ∼20% immediately and 3 days after performance of eccentric contractions in the injured TA muscles compared with contralateral control muscles (Table 1). There were no differences in the Kd of [3H]PN200-110 binding between injured and contralateral control TA muscles. Also, the Kd was not different between time points for either group.
The ratio of the Bmax for [3H]ryanodine binding to Bmax for [3H]PN200-110 binding was 1.2 ± 0.1 in control TA muscle. Most biochemical studies report a ratio of ryanodine-to-dihydropyridine receptors near 1 (ranging from 0.9 to 1.3) in mammalian fast-twitch muscle (1, 5, 7). There was no significant change in the ratio in injured TA muscles immediately after injury induction (1.09 ± 0.07), but the ratio decreased in injured TA muscles at 3 days (0.80 ± 0.1).
The primary objective of this study was to determine whether the performance of eccentric contractions would disrupt the affinity (i.e., Kd) and maximum number of binding sites (i.e., Bmax) for dihydropyridine and ryanodine receptor ligands in mouse TA muscle immediately after and 3 days after eccentric contraction-induced injury, which presumably could contribute to the E-C uncoupling and strength deficits that have been observed. We hypothesized that, if eccentric contractions resulted in irreversible denaturation of either receptor, then Bmax values would be expected to decrease. Moreover, because ryanodine and dihydropyridine receptors are influenced by a number of ancillary proteins (e.g., FKBP12, calmodulin), disruptions in the ability of the receptors to bind these proteins may alter Kd; however, specific changes in Kd would depend on the nature of the interaction of the specific protein with the receptor. The results suggest that neither E-C uncoupling nor strength losses in mouse muscles immediately after eccentric contraction-induced injury stem from disruptions in the integrity of either the ryanodine or dihydropyridine receptors. On the basis of the receptor binding experiments, neither the number (Bmax) nor the sensitivity (Kd) of the ryanodine and dihydropyridine receptors was reduced immediately after injury induction (Table 1). The finding that [3H]ryanodine binding is not significantly altered immediately after injury agrees with our previous study showing that intrinsic SR Ca2+ channel function is generally unaffected immediately after injury (19). When stimulated by drugs known to activate the SR Ca2+ channel, the ability of the SR to release Ca2+ was not significantly impaired immediately after injury when measured by using confocal laser scanning microscopic or fluorometric techniques, although small but significant reductions (6%) in SR Ca2+ release were detected when measured with a Ca2+ minielectrode (19). Previous work from our laboratory indicating that the neuromuscular junction (34), plasmalemma (34, 36), and t tubules (19) are not compromised after eccentric contractions suggests that the failure in E-C coupling occurs at or below the level of the voltage sensor. Therefore, our previous work and the present data suggest that the impaired SR Ca2+ release observed immediately after injury during tetanic excitation (2, 3, 19, 36) results from a communication failure between the dihydropyridine and ryanodine receptors and not a failure of the receptors themselves.
In contrast to the response immediately after injury, a decrease (16%) in [3H]ryanodine receptor binding was observed 3 days after the injury to mouse anterior crural muscles. A loss of functional ryanodine receptors in the injured muscles may explain the reduction in the ability of 10 mM caffeine to increase force during tetanic and subtetanic contractions in injured EDL muscles 3 days after injury. Specifically, caffeine increased tetanic force 35% immediately after injury and only 13% at 3 days. Similarly, caffeine increased subtetanic forces 59% immediately after injury and only 30% at 3 days. Therefore, mouse skeletal muscle exhibits both reduced ryanodine receptor ligand binding (present study) and less effective Ca2+ release from the SR Ca2+ channel during contractile activation (with and without 10 mM caffeine exposure) 3 days after injury (present study, Ref. 19).
Although a loss in functional ryanodine receptors by 3 days postinjury could promote E-C uncoupling, it does not appear that this is the primary cause of the E-C coupling failure in the muscles. The main argument against a loss in ryanodine receptors as the primary contributor to E-C uncoupling is that it does not appear to affect anterior crural muscle force production. EDL and TA (i.e., anterior crural) muscle strength deficits are unchanged or improved 3 days after injury during tetanic activation (present study, Refs. 17, 19, 21, 34). Reductions in [3H]ryanodine receptor binding (present study) and intrinsic SR Ca2+ release rate (19) at this time may have occurred in fibers that already had reduced force output and that were undergoing some degree of degeneration.
[3H]PN200-110 binding to dihydropyridine receptors was actually increased (20%) immediately and 3 days after injury. Whether the increase in [3H]PN200-110 binding reflects an absolute increase in receptor number or the uncovering of a previously "silent" fraction of receptors for binding is unknown. Upregulation of dihydropyridine receptor gene expression has been reported in skeletal muscle after disruption of normal muscle excitation via denervation or tetrodotoxin treatment (24, 25, 28). Moreover, rapid (i.e., 30-60 min) down-regulation and subsequent upregulation of dihydropyridine and ryanodine receptors have been documented in cardiac muscle perfused with hypocalcemic and normocalcemic buffers, respectively (40). Although the normal function of the plasmalemma and neuromuscular junction does not appear to be impaired after eccentric contraction-induced injury in our model (34), we have previously reported transient increases in nicotinic acetylcholine receptor concentration in mouse TA muscle after eccentric contraction-induced injury (34). Conceivably, the loss in muscle protein observed between 5 and 28 days may stem from the transient denervation-like response of the muscle, as well as from the sarcomeric damage caused by the eccentric contractions. Nonetheless, it does not appear that a loss of dihydropyridine receptors or alteration in their binding capacity explains the disruption in E-C coupling and strength loss during the first several days after eccentric contraction-induced injury.
The exact site(s) of the E-C uncoupling in the injured muscles remains unknown. In previous work, we have provided indirect evidence that the lesion is at the interface of the dihydropyridine and ryanodine receptors, but this evidence has been deduced from eliminating other potential sites (i.e., neuromuscular junction, plasmalemma, t tubule, etc.). We continue to suspect that the lesion in E-C coupling in the injured muscles is at the interface between the two receptors. For example, disruptions in any one of the numerous ancillary proteins (e.g., triadin, calmodulin, FKBP12, junctin, calsequestrin) associated with the dihydropyridine and ryanodine receptors could contribute to the uncoupling (9).
There is evidence that the E-C uncoupling results from disruptions in the t-tubular membrane system. Previously, we have shown that t tubules become disrupted immediately after both eccentric and isometric contractions in mouse soleus muscle in vitro (35). However, we found no significant correlations between the degree of t-tubular membrane disruption and the reduction in maximal isometric force or release of lactate dehydrogenase (35). Recently, it has also been reported that membrane systems involved in E-C coupling are disrupted after eccentrically biased exercise in rat fast- and slow-twitch muscle fibers (31) and eccentric contractions in single mouse muscle fibers (39). However, neither study correlated the degree of the strength deficit with t tubule membrane disruption. Nevertheless, the pervasive and long-lasting disruption of membrane systems involved in E-C coupling (from immediately after injury to 10 days postinjury) in rat skeletal muscle after downhill running (31) is consistent with our observation that E-C uncoupling is immediate and long lasting (to at least 5 days postinjury) in mouse EDL muscle after the performance of eccentric contractions in vivo (19, 33).
The observation that 10 mM caffeine significantly increases Po (35%) and subtetanic force (59%) in injured EDL muscle, whereas it has no significant effect on Po and subtetanic (i.e., 100 Hz) force in contralateral control muscle, confirms previous findings that E-C coupling is impaired in mouse skeletal muscle after injury (2, 3, 19, 36). Estimates of the contribution of E-C uncoupling to the Po reduction in the first 3 days after injury (14-28%) are significantly lower in the present study than our previous estimate of 75% (19, 33). Estimates from the present study would be accurate if E-C uncoupling stemmed solely from defects in the ryanodine receptor and caffeine was capable of completely restoring normal tetanic Ca2+ transients. However, data from Ca2+ imaging (2, 19), caffeine-induced contracture force (19, 36), SR Ca2+ release via spectrofluorimetry (19), and ligand receptor binding (present study) experiments all suggest that reduced tetanic Ca2+ transients do not stem from defects in the ryanodine receptor immediately after injury. On the other hand, the contribution of E-C uncoupling to the Po deficit would be underestimated in the present study if the dihydropyridine receptor-induced activation of ryanodine receptors is compromised because 10 mM caffeine in mouse EDL muscle does not elicit any apparent SR Ca2+ release or force production (i.e., based on resting muscle tension) independent of electrical activation. Therefore, defects in the E-C coupling pathway upstream of the ryanodine receptor and defects in force-generating and -transmitting structures presumably prevent caffeine from fully restoring peak force in injured EDL muscles.
In summary, mouse anterior crural muscle strength deficits after eccentric contraction-induced injury do not stem from disruptions in ryanodine and dihydropyridine receptor integrity. These data are not inconsistent with the hypothesis that communication failure between the dihydropyridine and ryanodine receptors is the cause of the E-C uncoupling in mouse skeletal muscle after the performance of eccentric contractions.
This research was supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant AR-42761.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2004 the American Physiological Society


text:
A general classifier module to allow Bayesian and other types of
WWW: http://classifier.rufy.com/
make generate-plist
To install the port: cd /usr/ports/devel/rubygem-classifier/ && make install cleanTo add the package: pkg install rubygem-classifier
cd /usr/ports/devel/rubygem-classifier/ && make install clean
pkg install rubygem-classifier
PKGNAME: rubygem-classifier
SHA256 (rubygem/classifier-1.3.4.gem) = ac5754c0d607b58af008afd479b6bbb3a8d6c1cef04677d335f57846c5455a5d
SIZE (rubygem/classifier-1.3.4.gem) = 26112
NOTE: FreshPorts displays only information on required and default dependencies. Optional dependencies are not covered.
No options to configure
Number of commits found: 16
Convert USES=gem:autoplist to USES=gem since autoplist is default
create USES=gem and update rubygem- ports to use it
Note that for now ports still have to have USE_RUBY=yes to use USES=gem
Differential Revision: https://reviews.freebsd.org/D6070
Remove ${PORTSDIR}/ from dependencies, categories d, e, f, and g.
With hat: portmgr
Sponsored by: Absolight
Set NO_ARCH for remaining rubygem-* ports with no arch dependent files
Obtained from: DEVELOPER_MODE
With Hat: ruby@
Sponsored by: RideCharge Inc / Curb
devel/rubygem-classifier: update to 1.3.4
- Add LICENSE
- Remove leading indefinite article from COMMENT
- Add stage support
Add NO_STAGE all over the place in preparation for the staging support (cat:
devel part 4)
- ruby@ should own these
- Trim header while here
- Reassign to the heap
- Thank you for your years of service
With hat:: portmgr
- Update to 1.3.3
- Remove MD5
PR: ports/153038
Submitted by: myself (pgollucci)
Approved by: maintainer timeout (firstname.lastname@example.com ; 15 days)
Sponsored by: RideCharge Inc. / TaxiMagic
- Mass fixup of WWW: lines pkg-descr based on rubygems.org Homepage meta info
Prompted by: distilator
With Hat: ruby@
Sponsored by: RideCharge Inc. / TaxiMagic
- Update to 1.3.2
PR: ports/151238
Submitted by: myself (pgollucci)
Approved by: email@example.com (maintainer)
Sponsored by: RideCharge Inc. / TaxiMagic
- RF -> RG conversions
With Hat: ruby@
- GEMS are always RUN_DEPENDS of other GEMS
- Bump PORTREVISION when something other then BUILD_DEPENDS changes
- Some minor verticle whitespace in some ports for consistency with the rest
PR: ports/147551
Submitted by: pgollucci@ (myself)
Reviewed by: portmgr (pav)
With Hat: ruby
A general classifier module to allow Bayesian and other types of
WWW: http://github.com/cardmagic/classifier/tree/master
PR: ports/141807
Submitted by: Peter Schuller <peter.schuller at infidyne.com>
Servers and bandwidth provided byNew York Internet, SuperNews, and RootBSD
No vulnerabilities have been reported in the past 14 days
* - modified, not new
All vulnerabilities


text:
Make a contribution to the Writers' Trust of Canada Donate Now
A highlight of our capital's social calendar, Politics and the Pen is a grand celebration of Canadian political and literary cultures. Held annually at the Fairmont Château Laurier, this unique fundraiser brings together national politicians, talented writers, prominent diplomats, and notable arts and business leaders—all in support of the Writers' Trust's mandate to advance, nurture, and celebrate Canadian writers and writing
Hosted by Hon. Rona Ambrose and Hon. Scott Brison, Politics and the Pen 2017 took place on May 10. As always, the climax of the evening was the presentation of the $25,000 Shaughnessy Cohen Prize for Political Writing, named in honour of the spirited and inspiring parliamentarian and generously sponsored by Aimia.
This year's year's finalists were announced on March 21, and were selected by a jury composed of CBC foreign correspondent Nahlah Ayed, National Post columnist Colby Cosh, and former Member of Parliament Megan Leslie. Click below to read more about each finalist.
Kamal Al-Solaylee for Brown: What Being Brown in the World Today Means (To Everyone), published by HarperCollins Canada
Christie Blatchford for Life Sentence: Stories from Four Decades of Court Reporting – Or, How I Fell Out of Love with the Canadian Justice System (Especially Judges), published by Doubleday Canada
Ian McKay and Jamie Swift for The Vimy Trap: Or, How We Learned to Stop Worrying and Love the Great War, published by Between the Lines
James McLeod for Turmoil, as Usual: Politics in Newfoundland and Labrador and the Road to the 2015 Election, published by Creative Publishers
Noah Richler for The Candidate: Fear and Loathing on the Campaign Trail, published by Doubleday Canada
The Writers' Trust of Canada extends enormous thanks to the 2017 Politics and the Pen co-chairs, Alayne Crawford and Patrick Kennedy, and to committee members Jim Armour, Maureen Boyd, Heather Bradley, Catherine Clark, Elizabeth Gray-Smith, Dan Mader, Francoyse Picard, Elizabeth Roscoe, and Max St. Pierre.
For questions about Politics and the Pen, please contact:
Kayla Calder, Coordinator of Special Events and Sponsorships
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For more details about opportunities, recognition, and to see a list of our current sponsors...More
We asked some of Canada's finest writers about their summer reading in 2017.
Read their Recommendations.
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text:
Miley Cyrus arrives in Belfast amid blaze of controversy
Pop wild child Miley Cyrus arrives in Belfast today – bringing a controversial show of raunchy content and pro-drugs messages.
Thousands of fans will pack into the Odyssey Arena tonight as the singer's Bangerz world tour lands in Northern Ireland.
The young American's show has raised eyebrows with crotch-grabbing routines and scantily designed costumes. The uninhibited daughter of country singer Billy Ray Cyrus first found fame as a child star in wholesome Disney series Hannah Montana.
But fast-forward a few years and, aged 21, she is as well-known for her sexually suggestive "twerking" dance moves and sticking her tongue out as she is for her songs such as Wrecking Ball, We Can't Stop and Adore You.
Miley Cyrus Bangerz tour: Here's a parental advisory - it's your fault if you take child to this gig
Miley has been hitting the headlines during the Bangerz tour British dates, particularly for provocative behaviour and voicing a pro-drugs message at her London concert. Following a barrage of criticism about the popstar's risqué antics, country music legend Dolly Parton, who is Miley's godmother, has come to her defence.
"I'll never say anything bad about Miley 'cause I know she's smart," Dolly said.
"And I know she's talented. And I know she's had to go to drastic measures to try to make her point: 'Leave me alone. I am not Hannah Montana anymore. I want to grow up'."
The 68-year-old Country Music Hall of Fame member explained she faced similar criticism when she found fame.
"But I never let that stop me from being the business girl that I was," Dolly added.
"I knew my songs were good, even if I had been ugly as sin."
Belfast Telegraph
Related Content
- Miley Cyrus Bangerz tour: Here's a parental advisory - it's your fault if you take child to this gig


text:
Khloe Kardashian Slams Kris Humphries: "He Rubbed Me the Wrong Way": Late Last Night
Kardashianity continues with Khloe Kardashian paying a visit to Jimmy Kimmel to give her side of the story that swept the nation: her sister Kim's marriage to and divorce from Kris Humphries. Khloe gives her spiel about having been against it from the start, and trying to prevent Kim from marrying him in the first place.
Amanda Seyfried has some charm in the holster…which might be a bit dangerous, considering how she uses it. Last year, the actress felt the need to settle her nerves before presenting an award at the Oscars. The key: alcohol. Unfortunately, the Oscars is a dry county, so Seyfried needed to amp up her "cuteness" to convince a guy to run out and find her a glass of liquor. But her desires don't stop at the drink. Seyfried also has a penchant for pranks, particularly ones wherein she has convinced her mother that she has been arrested, with the help of some cops she managed to coerce. This girl is dangerous.
This just goes to show you: being famous allows you to live our your childhood fantasies. As a kid, Chris Pine was so in love with Buffy star Kristy Swanson that he wrote a letter to Premiere Magazine asking for her phone number. Of course, he never got it. But good ol' Jimmy Kimmel is in the wish-granting business, and gives Swanson a call to profess Pine's love for her. The results are quite hilarious.
Maya Rudolph is wonderful in all sorts of ways. So when this weekend's Saturday Night Live takes place with her at the wheel as host, things should be phenomenal. But the wonders will continue, as Rudolph informs us that one Amy Poehler might be stopping by too. She also has a Public Service Announcement in the works about mispronunciation of Hollywood icons' last names.


text:
In the stuffy and imperious world of concert pianists, Jean-Yves Thibaudet gets nearly as much attention for his attire as for his musicianship: The showman has a penchant for sporting fire-engine-red socks with his antique tails. But thankfully his virtuoso playing has not exactly gone unnoticed.
Now billed as the Champion of the French Impressionists, Thibaudet made his symphony orchestra debut at the ripe old age of nine. The child prodigy's choice of music? A concerto by Maurice Ravel, of course. After winning the gold medal from the Conservatory in Lyons at age 12, Thibaudet attended the Paris Conservatoire, where his natural affinity for impressionism was nurtured by teacher Lucille Descaves, herself a student of Faure's and Ravel's. During his teen years Thibaudet racked up musical competition victories in Italy, Japan and America. By 1981 the 18-year-old was being heralded as a sensation, and today, at 38, he is one of the most in-demand soloists on the classical circuit. His elegant playing, unique sense of color, brilliant technique and revealing interpretations -- particularly of romantic and impressionistic works -- have also led to a successful recording career, with more than two dozen albums to his credit.
While Thibaudet has built his reputation on French impressionism, he's no one-trick pony. He has explored the works of Chopin and Liszt, Wagner and Rachmaninov. And in 1997 the classical pianist took a left turn to record Conversations with Bill Evans, an album of compositions by the late jazz pianist whose style was highly, you guessed it, impressionistic. The record was an impressive jazz effort by a classical musician and earned Thibaudet Germany's Echo Award in 1998. Last year he released an album of Duke Ellington compositions, and while no one will mistake him for Herbie Hancock or Marcus Roberts, Thibaudet's appreciation of jazz is obviously sincere.
But this weekend in Houston Thibaudet will stick with the stuff that made him a star: impressionism and romanticism, Debussy's 12 preludes, Book II and selections by Chopin. You can bet on his famous footwear, too.
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Jean-Yves Thibaudet performs at the Wortham Center's Cullen Theater, 500 Texas, on Friday, January 14, at 8 p.m. For more information, contact the Society for the Performing Arts at (713)227-5134. Tickets range from $22 to $32.


text:
The aroma is nice on this one altho based on smell alone I would have to call it RASPBERRY Acai Sencha as I can smell way more Raspberry than Acai.
The The Sencha Base is very good. The Raspberry and Acai Flavors are about medium strength – definitely NOT overdone. I think the strength of them work really well here. I can taste a little more Acai than Raspberry so it all evens out in the end :)


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text:
This is a quick bread I made so I could use a delicious new ground Cinnamon that my mom got me.
I didn't know Cinnamon could be so powerful. All my life I've used cheap ground Cinnamon from the grocery store. Which doesn't taste completely bad, but it's very mild compared to the 'good stuff'.
It's a very nice Vietnamese Cinnamon my mom found at the store a few days ago. I could smell the spicy goodness through the plastic wrapping.
Let me tell you, it changed my life. It changed it so much, that I ordered Vanilla Beans online. I'm determined to discover what I've been missing by buying good spices and trying them all out.
This recipe was adapted from many combined recipes. I couldn't find just one that I liked, so I mixed and matched ingredients. It ended up really good (for a made up recipe). Soft and delicious!
It's not super sweet, if that's what you're looking for. This is a good bread that can be used for sandwiches and toast.
I made French Toast with it. Amazing!
Sorry that I don't have pictures for the procedure. I made this bread at night in my kitchen, where the lighting isn't good at all. Scroll down to the end of the post to see some links for other recipes.
3.5 cups All Purpose Flour (or bread flour)
4 tbsp Butter
3 tbsp Sugar
3 tsp Yeast
1/4 cup WarmWater
3/4 cup Milk
Pinch of Salt
For the filling:
1.5 tsp Cinnamon -plus- 2 tbsp Sugar
-Put the flour, softened butter, salt and 2 tbsp of the sugar together in a mixing bowl. Don't mix yet. Set aside.
-Mix the warm water, yeast and 1 tbsp sugar and let it proof for 5 minutes. You'll know it's ready when it gets bubbly.
-Once the yeast has proofed, mix it in with the flour and incorporate everything together.
-I use my stand mixer with the hook attachment to kneed the dough. It's easier and faster. But you can kneed by hand if you want.
-Now that the ingredients are incorporated, turn the mixer on and start adding the milk a quarter cup at a time. You may not need to add the entire amount depending on how humid your area is that day. Just keep adding milk until you have a soft (non-sticky) dough.
-Knead for 5 minutes on the stand mixer (10 minutes if you're doing it by hand).
-Let it rise for an hour and a half.
-Flatten the dough into a rectangular shape and a third inch thick.
-Prepare the cinnamon and sugar mix. Sprinkle on top of the dough.
-Then roll and put it in the bread baking dish. Let it rise for another hour.
-Bake for 40-45 minutes at 350 degrees.
More Cinnamon Raisin Bread recipes:
1. Honey & Butter
2. eat a duck i must
3. panini happy


text:
Budding builders
Thu, 06/05/2014 - 6:00am News Staff
Former lawmaker Kopp vies for GOP nod
A collaborative project involving elementary school students and administrators, contractors, a nonprofit and government leaders is now underway. Student s at Gunnison Elementary School gathered on the last day of school this past Friday to celebrate the groundbreaking of a new playground. The project was spearheaded by five fifth-grade students under the watchful eye of Principal Sally Hensley.


text: Hi everyone. I am a white guy from the UK. My first gf (Emma) was seduced by BBC when we were both 18. We'd been dating 2 years. It was hard but we stayed together, partly because I loved her but mainly because he didn't want her as a steady gf. I'd never felt my pride as badly hurt as when I agreed to take her back that first time, knowing that she'd all been up for being is full time girl but had been knocked back by him. In the end she had apologised to me, promising it was a one time thing, that she hadn't been thinking straight so I stood by her. At the time I felt like I'd won and he'd lost and my ego was soothed a little. It soon transpired she couldn't give him up. Despite Jason (the BBC in question) treating her quite rudely (I treated her like a Princess) and her becoming upset after each time she was him and promising me that was the last time - her panties dropped for him again and again. Every time Emma would cry and say sorry and I would try again, my pride eroded a little bit more but I continued to stand by her as she would beg me to forgive her and not leave her - telling me again and again that it was a mistake that would not happen again - tat she needed me. We of course talked about it, not sexually at first, but working out why she felt the need to keep cheating. We looked at it to begin with from the perspective that she had a problem that we could work through, that perhaps it was due to her needing attention and so on. The chats led to us being very truthful with each other. Of course a large part of the reason she kept seeing him was the bliss he gave her - and she hesitantly admitted to me about his greater size, greater stamina, greater dominance and greater skill. She was gentle with my feelings but of course I pushed for details. Turned out he was nearly twice as long as me (I'm around 5.5") and 'much thicker'. He could go for a long time, the first time she was with him they'd gone back to his at 3am and not finished properly (they had little breaks) she reckoned until about 6-7am and it had not been slow and tender sex, he had pounded her. I couldn't believe it at first but she told me he could cum, lose only a little hardness and recover to go again in a few minutes. She grew to become very open about how much pleasure he brought her, how the sex was 'out of this world' and 'totally addictive' and how she 'came and came and came'. She began to become frustrated with me in bed as she tried to remain faithful and I tried to compete with what he could do to her - but of course I couldn't. She was my first gf, I didn't know what to do, and my shame increased again as although hearing all this detail was slowly breaking my heart - my dick began to betray me and stand to attention whenever she talked about him and I began to feel completely in awe of him. We were together through two years of this and I learned to put up with it losing my confidence and manliness in inches. Wen I looked back I realised I'd shared my gf with another man for the entire time of our relationship and this had just been my 'normal' - I didn't know any different. Sometimes she would try really hard for me but he only lived around the corner from her and if two weeks went by without her caving in and seeing him I was lucky. Often the time between their trysts was far less. Eventually we split up (she left me of course) telling me it was time for her to be single although it wasn't as if I was stopping her having her fun. Anyhow, I was 21 and on the surface had had a nice relationship with a pretty, lovely girl and was off to uni. In reality I was left with no confidence, totally in awe and intimidated by BBC, hopelessly attracted to girls into it and unable to stop watching interracial porn in my spare time. As I looked at more porn I learned about cuckolding, that there were other white guys like me who had experienced similar. I'm 31 now and despite spending years trying to fight this and man up, being macho in public, in private I'm still totally in awe of black cock and the girls that love it. Sometimes I desperately want to man up… and manage it for a few weeks but can't manage it to last so am trying to accept my position at last. Would love to make friends and chat to others, cheers, Sean


text:
DENVER, Colo. Gates Corporation, a global diversified manufacturer of industrial, automotive, and heavy-duty aftermarket products, today announces the release of 566 part numbers, expanding its coverage of OE quality automotive aftermarket products across several categories.
The release includes the launch of Gates new RPM (Racing, Performance, Muscle) serpentine belt line. The racing belts feature a new look and more durable construction to accommodate a wide variety of drive load. The line will launch with 83 SKUs.
Gates expands its new Century™ Series belt line with the addition of 4 Stretch Fit®, 13 Micro-V® and 2 Dual-Sided belts. All Stretch Fit belts in the line now feature a new sleeve design with a custom link to specific installation instructions available online.
Gates continues to address specific market needs with the introduction of Accessory Belt Drive Kits for school buses as well as for the Ford E-450 Azure Hybrid Drive System. Each of the 84 new FleetRunner® Accessory Belt Drive Kits for the school bus market are designed for systems working in harsh environments with long idle times and high temperatures. Kits contain a FleetRunner Micro-V Belt and a Green Stripe® DriveAlign® HD Tensioner. The new Azure Solution Kit for the Ford E-450 Azure Hybrid Drive System contains the replacement belt, tensioner, and pulleys for the system.
Gates extends its popular hybrid polymer hose line with new Hybrid Polymer Whip and Water Hoses that won't kink or curl. The Hybrid Polymer Whip Hose reduces wear and tear and features a ¼" male ball swivel and ¼" female NPT fitting while the Hybrid Polymer Water Hose has heavy-duty nickel-plated fittings and spring guard. Both hoses are available in a variety of lengths.
"Every new product release allows Gates to showcase its tradition of innovation by introducing products that address the latest market needs," said Scott Howat, Gates Director of Marketing and Product Management for the North American Aftermarket. "We're constantly striving to improve our product offering and expand coverage to remain the market leader in OE-quality automotive aftermarket parts."
For more information about this release, contact Scott Howat at 303.744.4654.
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Search from over 10 Million Auto Parts
- Fast Shipping
- 30-Day Return Policy
- Low Prices
2004-2006 Ford F150 Fog Light Lens - Action Crash FO2592197C
Product Description
An Action Crash Fog Light Lens can be used on Ford F150s of model years 2004, 2005 and 2006. Fog Light Lenses are high-powered light enhancements that can enhance your ability to see when driving conditions are bad. Enhanced Fog Light Lenses can be placed at the rear, augmenting the presence of your car or truck to other cars on the road. Adequately functioning Fog Light Lenses can provide greater safety for you along with other people commuting on the interstate specifically in shadowy and foggy circumstances. A Fog Light Lens adds to the when you can't see in order to prevent accidents. Ford F150s from '04, '05 and '06 will work with this Fog Light Lens. Other makes and models probably will not be compatible, so this part is not intended to be installed on those vehicles.
Headlights were a perfect fit and they also had new bulbs. Quick shipping too, ordered Tuesday night and had them on Thursday. I recommend this product from this merchant.


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Originally published Friday, February 1, 2013 at 7:02 PM
Vancouver bowler wins 4A girls state title
Madison Crockett of Skyview High School won the Class 4A girls bowling state championship by 57 pins over Kayla Zabel of Everett's Cascade.
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UNIVERSITY PLACE — Madison Crockett of Vancouver's Skyview High School won the Class 4A girls bowling state championship by 57 pins on Friday at Narrows Plaza Bowl.
Crockett had a six-game total of 1,324 pins for a 220.6 average. Kayla Zabel of Everett's Cascade High totaled 1,267 for a 211.2 average. Alyssa Feller of Puyallup's Rogers High (1,245) was third.
Battle Ground's Wylicia Faley, the defending 4A individual champion, was fifth at 1,216, just behind fourth-place teammate Adrianne Schock (1,242).
Battle Ground, the defending team champ, has a commanding lead over Cascade going into Saturday's final day of competition.
In the 3A/2A/1A tournament, Janaye Kilgore of Longview's Mark Morris won with 1,295 pins, 84 more than runner-up Cortnie Brathovd of Lacey's North Thurston.
Last year's champ, Karissa Shiftlet of Kennewick, was fourth (1,183).
Mark Morris, the defending champ, has a narrow 3A/2A/1A team lead over Timberline of Lacey and R.A. Long of Longview.


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East Penn Elementary School awarded $1,000 by Walmart
Gail Maholick/TIMES NEWS Walmart representatives stopped by East Penn Elementary School to present a check of $1,000 as part of the Teacher Reward Program. From left are, Christen Strohl, zone supervisor; Brian Smith, assistant manager; and Gretchen Laviolette, principal at the school.
Teachers at East Penn Elementary School are great, at least Walmart thinks so.
Walmart representatives, Brian Smith, assistant manager; and Christen Strohl, zone supervisor, recognized 10 teachers and support staff with a check of $1,000 to help the school purchase much needed classroom supplies as part of the Teacher Reward program.
Walmart and Sam's Club locations are awarding more than 45,000 educators with $100, infusing $4.5 million to schools across America.
Selected by Principal Gretchen Laviolette as the 10 representatives of the school were, Rhonda Zerbe, Debra Biery, Sherry Snyder, Larry Koons, Ashley Frey, Patti Ebbert, Kay Novatnack, Jane Brunner, Larry Markell and Debra Lilly.
"Walmart is committed to supporting the local community and addressing unmet needs," said Smith. "We know that teachers are on tight budgets to provide supplies for their classrooms and Teacher Rewards helps offset those costs."
"The teachers will decide how to spend the money to provide some much needed supplies for the school," said Laviolette, principal. "I guess we have some shopping to do."
Each Walmart store, Distribution Center and Sam's Club location across the U.S. will select one local kindergarten through eighth grade school and provide $1,000 to selected schools. All of Wal-Mart's 4,558 facilities nationwide are eligible to participate in the Teacher Rewards program.
In 2009, educators' top purchases through the Teacher Rewards program included 25,000 report folders, 24,000 packs of pens, pencils and crayons, 14,000 packs of paper, 13,000 packs of markers and 10,000 binders and clipboards. In addition to other essentials items - showing teachers need basic supplies to help support their classrooms.
This is the second year Walmart has supported educators with Teacher Rewards, as part of the company's ongoing support of education initiatives. In 2009, Walmart and its Foundation gave more than $53 million to fund educational programs in communities across the country.


text: Check out our great range of home and garden magazine subscriptions and save when you subscribe today! isubscribe has a subscription to suit every need – whether you're an amateur interior designer after a little inspiration for your home or if you've got a green-thumb and are looking for ways to make your garden even more beautiful. Our array of magazine subscriptions will provide you with the knowledge, advice and tools you need to become truly house-proud.


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- Age / Gender:
- 30, Male
- Location:
- The Magical Casino Realm
- Joined:
- 6/2/10
- All Stats >
What is Zovos? What is life? What Zovos is What life is. Life that is encouraged for one to experience.
User Statshot
- Community Stats
Level 5 Musician
Normal Whistle
Ranked as Civilian
Contact Info / Websites
Latest News
I made a new album called "Garbit-Bang"! You can listen to it at http://listen.grooveshark.com/. Just type "Zovos" and "Garbit-Bang" in the search bar. I hope you like it! :D
Recent Game Medals
Blind Runner 10 Points Daredevil ain't got nothin' on you. Medal Stats.
The Naked Mile 10 Points If I weren't legally obliged, I'd go nude too. Medal Stats.
Puppy Love 10 Points Like OMG, Totes jelly. Medal Stats.
Shoop Da Whoop! 10 Points Imma firin mah lazor!!! Medal Stats.
GODLIKE! 100 Points You shake hands with the Almighty himself! Medal Stats.
The Man Who Owns Time 10 Points "Dr. Who" They name you, "His life, so bizarre." Medal Stats.
Human Appliance 10 Points Science is bad, M'kay? Medal Stats.
Mutually Assured Destruction 10 Points Everything dies and it's all your fault. Medal Stats.
Dressing in Drag 10 Points Rambo is quite the prankster! Medal Stats.
Tails Never Fails 10 Points A classic for bidding! Medal Stats.
Total Medals Earned: 640 (From 68 different games.)
Latest Audio Submissions
|Is it Dead?
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|Video Game Loop
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Latest Shared Creations
Zovos Added to skins for Skincraft Feb 11, 2012. Load Level
Zovos Added to skins for Skincraft Feb 11, 2012. Load Level
Self Healin Added to levels for Time Fcuk Jan 28, 2011. Load Level
Gahndozabvi Added to levels for Time Fcuk Oct 9, 2010. Load Level
91 Keys!!! Added to levels for Time Fcuk Aug 14, 2010. Load Level
The Vomiter Added to levels for Time Fcuk Aug 14, 2010. Load Level
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Momiga Rated 3.0900 Stars the Most Minimalist Game ever. Co-operation Rated 4.0200 Stars An 8bit platformer where you control 2 guys to navigate the stage Action - Platformer - Puzzle Looming Rated 4.3600 Stars In a place called Looming, remnants of the past lie abandoned in the dust. Adventure - Other Babies Dream of Dead Worlds Rated 3.9000 Stars What do babies dream about when they're too young to remember? Action - Platformer - Other


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wrestling / News
MVP is Done With NJPW – Says He's Open to WWE or TNA Return
– MVP posted the following today on Twitter…
"I informed NJPW that I would no longer accept dates. I would like to thank @njpw1972 for allowing me to realize a dream! I love Japan and will forever be grateful. I left on good terms as always.
I WILL return to wrestling eventually. The door is open for a return to WWE, NJPW, and even TNA. However my focus now is developing my TV show."
Credit: prowrestling.net
Must-read news from around the site:
* Karissa Shannon puts her thong-clad booty front and center
* Rita Ora gets leggy in a super short dress
* Kanye West hints at upcoming album
* Check out seven new pics from Fast and Furious 6
* How to Save the Die Hard Franchise
* The Top 8 Video Game Franchises That Should Go Away
* The Top 8 Buddy Cop Teams


text:
This script is Copyright (C) 2013-2014 Tenable Network Security, Inc.
Synopsis :
The remote Scientific Linux host is missing one or more security
Description :
This update fixes the following security issue :
- It was found that the Scientific Linux 6.1 kernel update
(SLSA-2011:0542) introduced an integer conversion issue
in the Linux kernel's Performance Events implementation.
This led to a user-supplied index into the
perf_swevent_enabled array not being validated properly,
resulting in out-of-bounds kernel memory access. A
local, unprivileged user could use this flaw to escalate
their privileges. (CVE-2013-2094, Important)
A public exploit that affects Scientific Linux 6 is available.
Refer to Red Hat Knowledge Solution 373743 for further information and
mitigation instructions for users who are unable to immediately apply
this update.
The system must be rebooted for this update to take effect.
See also :
Solution :
Update the affected packages.
Risk factor :
High / CVSS Base Score : 7.2
Public Exploit Available : true
Family: Scientific Linux Local Security Checks
Nessus Plugin ID: 66490 ()
Get Nessus Professional to scan unlimited IPs, run compliance checks & moreBuy Nessus Professional Now


text:
ANOKA, Minn. - Forecasts for another dangerously cold day are triggering another round of school closures across Minnesota.
The Anoka-Hennepin Schools, the state's largest district, announced early Monday afternoon that all schools will be closed Tuesday and all evening activities cancelled due to dangerously low temps and wind chills predicted to reach 44 degrees below zero. Minneapolis and St. Paul School Districts quickly followed suit, announcing their schools would remain closed Tuesday as well.
Extended forecasts show warming for Wednesday, and administrators are planning on business as usual.
A posting on the Anoka-Hennepin Public Schools website details the decision.
- Tuesday is expected to be colder than Monday. The decision to close schools for students and staff is based on the official announcement of the U.S. Weather Service, which states, "Exposed skin may freeze in as little as five to 10 minutes... The combination of very cold air and strong winds will create dangerously low wind chill values. This will result in frost bite and lead to hypothermia or death if precautions are not taken."
- Staff should not report to work; buildings will remain closed.
- At this time we have no plans to make up lost days.
The University of Minnesota Twin Cities campus announced they are cancelling morning classes on Tuesday, but classes will resume at noon when the wind chill advisory is set to expire. The rest of the campus will remain open all day Tuesday for all other business.
Click here for a complete list of school closings and delays. .


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As his term in office nears conclusion, Gov. Bob McDonnell should use the waning weeks to make a positive and lasting change to how public officials operate in the commonwealth. He should support more stringent ethics laws that limit the type of impropriety that has tainted his time as governor.
Gov.-elect Terry McAuliffe made ethics reform a key part of his campaign platform and may prove to be an ally for Mr. McDonnell if he commits himself to winning passage of stronger ethics laws. Not only could the issue cultivate bipartisan support during a time of transition, but it serves the long-term needs of the commonwealth.


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ST extend PowerVR architectural licensing deal with Imagination
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STMicroelectronics (ST), Europe's leading chip maker, has extended its longstanding architectural licensing deal with Imagination Technologies to include the next two generations of Imagination's PowerVR graphics processing architecture.
The Kyro and Kyro II graphics accelerators from ST are based on the PowerVR Series3, which uses tile-based graphics rendering technology and hidden surface removal to minimise processing requirements.
The two companies say their partnership now includes the development and manufacture of a range of high-performance PC graphics and video accelerators based on PowerVR Series4 and Series5 technology in development at Imagination.
Tim Chambers, vice-president and general manager of ST's graphics product division, said: "The advantages of PowerVR will only increase as future applications increase in complexity, and PowerVR Series4 and 5 will offer users unrivalled performance without the price premium enforced on other graphics solutions by their outdated designs."
Peter Clarke is European correspondent for US sister newspaper EETimes.


text: With medical research accelerating and doctors chasing not only treatments but also outright cures for terminal illnesses, research centers are increasingly forced to make the hard decision between helping current patients and focusing on research for the future, especially when the two missions conflict. Though Vanderbilt-Ingram Cancer Center's choice not to participate in compassionate use frustrated the director of the melanoma program there, the lead investigator of the drug's trials in New York said the decision is understandable. "It takes money; it takes resources away from what you normally would be doing. So, each hospital would have to make that decision," said Paul Chapman, MD, lead investigator of the vemurafenib trials from the Memorial Sloan-Kettering Cancer Center.


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Olympic Gold
To the Editors:
The 1984 Summer Olympics were innovative, entertaining, safe and debt free [OLYMPICS, Aug. 13]. Peter Ueberroth, the man behind it all, should be Man of the Year for his contribution to world unity and the U.S.'s bright new image.
Terry L. Varvel
Corona, Calif.
The Olympic Games were so inspiring that they make me think I can do anything if I work hard enough.
Linda Morgan
Cadiz, Ohio
Your stories on these dedicated, disciplined, clear-eyed young athletes assure me that all is well.
Thomas C. Gordon
McCloud, Calif.
Watching Mary Lou...
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text:
A jar full of pennies has been handed in to our appeal, with a special dedication to a mystery World War One soldier.
The jar, full to the brim of loose change, has a special handwritten message attached to the front.
The dedication is to a former soldier, Horrace James Grainger, who fought from 1914 to 1918 with the Sherwood Foresters.
The jar was handed in at the Market Place Cafe, Ripley, as part of our Pennies For Our Heroes campaign.
We are asking readers to donate their loose change to our appeal so we can raise enough to plant trees to honour the area's World War One heroes.
We are hoping someone out there might be able to shed some light on who the mystery soldier was.
We are urging anyone with information about Horrace Grainger to get in touch and help us commemorate the brave soldier.
Chairman of the Ripley branch of the Royal British Legio,n Dean Fowler said he hoped someone would come forward and provide information about who Horrace was.
He said: "It would be brilliant if he still had family living in the area who might read this and get in touch.
"This is a very important year for all of us to comemorate the soldiers, including Horrace, who fought for us. We want to thank everyone for donating their pennies to the campaign, please continue to do so!"
Meanwhile, we have had another cash count and after endless hours of counting coppers, our current total has just tipped the £500 mark and would like to say thank you to those who have donated, but we still need to raise more so keep donating your change.
We have been asking readers to donate their spare change so we can raise enough to the plant treesto honour those who fought in the 1914-1918 war.
Our plan is to use the money to plant trees in Ripley, Heanor and Alfreton as we mark the 100th year since the start of the Great War.
We have teamed up with Amber Valley Borough Council and the Ripley branch of the Royal British Legion, which are backing our campaign.
Simon Gladwin, assistant director of landscape services at Amber Valley, said the campaign was proving to be successful.
He said: "Whilst it would be nice to plant the trees in the summer, that is the worst possible time to do so. I think we should aim for the planting of the honorary trees in either October or November, which would tie in very nicely with Remembrance Day."
How you can donate to the Pennies appeal:
You can leave your jam jars/pennies with the reception staff at Amber Valley Borough Council's central office on Market Place, Ripley.
You can also drop them at Market Place Cafe, Market Place, Ripley. Just ask staff for details.
At our offices at 8 Heanor Road, Ilkeston, DE7 8ER.
And you can also help the Ripley branch of the British Legion with information on our war heroes, contact us via email at email@example.com, or over the phone on 0115 9446180.


text:
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Tag Archives: Netherlands
Bed and breakfast in Giethoorn: discover Dutch Venice
From a bed and breakfast in Giethoorn you can climb aboard a little boat and start a voyage of discovery. After a magnificent boat trip along the idyllic canals and underneath low bridges it is lovely to get well-rested in a hospitable B&B in Giethoorn. It is the way to truly experience this Venice of the Netherlands!. Continue reading
Posted in B&B tips Tagged B&B, bed & breakfast, bed and breakfast, boat, Giethoorn, holland, Netherlands, Venice Leave a comment
Bed and breakfast in vibrant Amsterdam
Amsterdam is the vibrant capital of the Netherlands. A city full of history and culture, where amazing events are organised, and where you can shop endlessly. Read our sight-seeing tips and find more than two hundred bed & breakfasts in Amsterdam. Continue reading
Posted in B&B tips Tagged Amsterdam, B&B, bed & breakfast, bedandbreakfast.eu, Netherlands Leave a comment
A romantic night in a B&B on a house boat
Have you ever spent the night in a bed and breakfast on a house boat? It is lovely and romantic to watch the sunset from your private deck. And cosy too, because many house boats are located along a vibrant town quay. Of course there are also house boats on which you can perfectly experience the quietness and peace of nature. Continue reading
Posted in B&B tips, Bed & Breakfast Germany, Bedandbreakfast.eu Tagged B&B, bed & breakfast, bedandbreakfast.eu, boat, house boat, Netherlands, romantic, special Leave a comment
Photos: building a bed & breakfast
Bed & Breakfast 'Het Vogelhuis' (The Birdhouse) has recently been expanded with two new guest rooms. Watch a photoreportage: from breaking down the garage and pouring a concrete floor to sheeting of the walls, placing the kitchen, bathroom equipment and stuccowork.. Continue reading
Posted in General, Starting a bed & breakfast Tagged B&B, bed & breakfast, bed and breakfast, building, Netherlands, photo reportage, rebuilding Leave a comment


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Aviva Premiership outfit Worcester have agreed a deal to sign Argentina international hooker Agustin Creevy.
Last Updated: 06/02/13 12:28pm
The 27-year-old will join the club from French club Montpellier in the summer along with fellow countryman Leonardo Senatore from Toulon and back Paul Warwick from Stade Francais.
"Agustin is a quality international player who will add real strength in depth and power to the pack of forwards we are building here at Warriors," said Worcester head coach Richard Hill.
"I really like the way he plays the game and the clear ball-carrying ability he possesses.
"Agustin is clearly very comfortable with the ball in hand and has very strong off-loading skills. His ability in contact is excellent. He speaks very good English, which is important, and is an experienced international player who will know Leonardo (Senatore) so I am sure they play well together.
"We have signed a very passionate rugby player whose attitude and dedication is superb. I am sure he will be a big asset for the Warriors as we plan for the future."
Creevy, who has 22 Test caps, has previously played for Biarritz and Clermont Auvergne.
Worcester also announced that they had recruited Creevy's fellow Argentina
international Ignacio Mieres for next season.
Fly-half Mieres will head to Sixways from Worcester's Premiership rivals Exeter.
"Ignacio is a superb goalkicker with a very high percentage of success who is very ambitious and keen to join us," said Hill. "Last season, he started the vast majority of games for Exeter as they were very successful and secured a top-six finish and, with it, Heineken Cup rugby."


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Welcome to PODS Research LLC
Revenue management systems present airlines with complex and interrelated questions – technical, procedural and organizational. With the emergence of international mega-carriers, intricate alliances and growing low-cost carriers, the RM questions facing airlines raise the stakes in an increasingly competitive environment:
- What kind of revenue management system fits our needs?
- What traffic and revenue impacts will a new revenue management system produce?
- How can we improve our current forecasting methods and optimization algorithms?
- How can we compete effectively with our competitor's fares and fare products?
- How can we improve the traffic and revenue performance of our alliances?
- How can we develop schedules that leverage the capabilities of our revenue management system?
PODS Research has unique qualifications to help answer these questions for our airline clients
The Passenger Origin/Destination Simulator (PODS) tests ideas, concepts and proposals in a computational environment that reflects the fundamental dynamic of air transportation – airlines define the available network alternatives (itineraries/products/fares) and passengers pick and choose amongst them.
The principal consultants, Dr. Peter Belobaba, Principal Research Scientist at MIT, Dr. Bill Brunger, former Senior Executive from Continental Airlines, and Craig Hopperstad, retired mathematician and scientist from Boeing, have seasoned knowledge of the industry and bring a wealth of practical, conceptual and theoretical experience to help airlines understand and solve their revenue management and planning issues.