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Chelsea vs Tottenham Hotspur (Spurs) Live Stream Free Soccer: Watch English Premier League Football (EPL) Online (Kick Off Start Time)
Chelsea travel crosstown to visit Tottenham at White Hart Lane on Saturday in what is an early test for two top clubs in addition to being a competitively fierce London derby.
Spurs boss Andre Villa-Boas has led his side to an impressive start to the season after acquiring some key players in the wake of Welsh international Gareth Bale's departure to Real Madrid.
Spurs have earned 12 points from five games and are level with arch-rivals Arsenal at the top of the Premier League standings.
Enabling such an early season surge Tottenham have the top defense in the division conceding just once this season. Chelsea has also been buoyed by their defense conceding just one more than Spurs.
Both managers will be looking for production from their respective signings as both clubs look to overcome injuries to regular starters.
Left-back Danny Rose is likely to make his return from a toe injury for Tottenham, but defender Younes Kaboul and midfielder Étienne Capoue remain doubtful.
Spurs will give winger Aaron Lennon a fitness test while striker Emmanuel Adebayor is out through illness.
For Chelsea, they will make a game time decision to see if midfielder Ramires is fit to face Spurs.
The Brazilian suffered a hip injury in Tuesday night's Capital One Cup win at Swindon and was taken off at half-time, but Jose Mourinho hopes to include him in a much-changed line-up at White Hart Lane.
Ramires had replaced Marco van Ginkel, who is out for six months, after undergoing knee surgery to repair a torn anterior cruciate ligament.
Kick-off for the match is at 7:45 a.m. ET and can be watched online here.


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American Indian Census Day April 2,2010 Fun Walks
Contributed by: Fun Walks
Date: 7/16/10
Date: 7/16/10
There were multiple fun walks on American Indian Census Day 4/2/2010 at IHC Community Wellness & Outreach Department (San Jose, CA)
This was a great event, for gathering the community and helping American Indians participate in the 2010 Census. The agenda for the event was from 9am - 3pm. Beginning with Opening Prayer, a healthy breakfast and lunch were served, a Census Department Speaker spoke, and we finished up the day with Closing Prayer. Many, many people came out to learn more about the Census and why it is important to the American Indian Community. We had multiple fun walks throughout the day, to keep people engaged and active. There was a total of 20 people who joined in the fun walks!!!
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subset: commoncrawl


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Alternative Title: e-trading
Learn about this topic in these articles:
stock exchanges
...developments have greatly influenced the nature of trading. By the 21st century, increased access to the Internet and the proliferation of electronic communications networks (ECNs) had allowed electronic trading, or e-trading, to alter the investment world. These computerized ECNs made it possible to match the orders of buyers and sellers of securities without the intervention of...
Toronto Stock Exchange
...Exchange, which originally used the acronym TSE, was the first North American exchange to replace fractional pricing with decimal pricing (1996), and it was one of the first major exchanges to adopt electronic trading (1997), abandoning its trading floor for a fully computerized system. In 2000 the TSE became part of a publicly traded company, TSX Group Inc.; two years later the exchange adopted...


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The following commentary does not necessarily reflect the views of AgWeb or Farm Journal Media. The opinions expressed below are the author's own.
Comments, questions, opinions...this is your chance to speak out regarding anything and everything reported on AgDay. Viewer feedback updated regularly.
I need the website for the farrier that was on the Monday morning show...his name was www.bob???? - I missed the rest so what is his name???
Also, you need to have a pamphlet made so we can understand the special sessions that you have with Mr. Gold and all others so we can understand what they are talking about when they talk about ie; downside, upside, old crop, new crop, burn something.; etc... I watch your show every morning and the ag industry I think runs the country... or we will starve. Let me know where I can purchase such a book or pamphlet to learn the trade. I have relations of my wife's side that farm 18,000 acres and would like to talk with them as if I knew something about the farmer.
Ron Thompson
P.S. - Great show... be watching you every day and Saturday morning...
Scott , Al . Why dont you show some of the farming operations around the Bakersfield , Ca . area this area is the bread basket of Calif , we have ever thing from farming , to cattle ranching , sheep , and a lot of other , ag related services in this area , John Deere even has three dealer in this , farming is very big in the South end of the Sajoquin Vally , but I hear very little about it , ever thing is not conected to Fresno , whitch I hear you talk about .
Thank You Bob Glenn
Tehachapi , Ca .


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a volcano exploding in to the sky
Canvas Draw Created May 17, 2013 640 x 460px Unless noted Copyright 2013 joba702.
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Whirlpool Washer Leaking Water
Model number LSR7300PQ2
The drain hose that goes from the water pump to the customers drain pipe was leaking near the bottom left side suspension support bracket of the washer.
Bouse, Arizona
Model number LSR7300PQ2
The drain hose that goes from the water pump to the customers drain pipe was leaking near the bottom left side suspension support bracket of the washer.
Bouse, Arizona
Merry Christmas!
The Holiday season is a time for family and friends to join us for the special get-together in which food and fun go hand in hand. With that comes cooking those wonderful meals everyone can enjoy. Dishwashers are used much more this time of year and to get the full cleaning power its always best to make sure your dishwasher is in prime working order.
We recommend using a dishwasher cleaner to reduce mineral deposits that can build up over time.
Affresh dishwasher cleaner with deodorizer – 6 tablets
Affresh dishwasher cleaner keeps your dishwasher fresh by penetrating, dissolving and removing mineral deposits and odor.
Rick helped a member in our Appliance Repair Forum on a newer style Maytag washer, model number MVWC200BW0, about taking apart the water drain pump to unclog it.
He uploaded two photos to show how to do it: Repair manual – need to unplug water pump
Drain Pump W10276397 Order now for same day shipping. 365 day return policy. RepairClinic.com
Over time, the water hoses that came with your new washing machine may leak or burst. It's a good preventive maintenance practice to check these hoses from time to time for any sign of wear or weakness. Often there's a small blister in the rubber of the hose, which could rupture. Most manufacturers recommend replacing the hoses every 5 years.
Note… If the hose ruptures, large quantities of water could gush from the hose. If it's the hot water hose that ruptures, the gushing hot water may scald anyone nearby.
For more peace of mind, one alternative is to use high quality stainless steel fill hoses. In addition, we carry the black rubber hoses supplied by the manufacturer– go to our Shop For Parts section and enter your model number to locate the ones for your unit. We also offer universal washing machine hoses.
Because your washing machine is so heavy, when it's not level, it can vibrate strongly during the spin cycle. If your washing machine is not perfectly level–with all four legs touching the floor–it can bang and rock back and forth, and even begin to "walk" across the room. This isn't good for the machine and may damage anything near the machine.
Your washing machine has adjustable, front leveling legs with a lock nut. You adjust the leg to the proper height, then tighten the lock nut up against the body of the machine to keep the leg from rotating.
Some machines have adjustable leveling legs in the rear also, and you can adjust them in the same way. Keep the machine as close to the floor as possible–the lower it is, the less likely it is to vibrate.
Most machines, however, have "self-adjusting" rear legs. You set these legs by tilting the entire machine forward onto its front legs (with the rear legs 3 to 4 inches off the floor) and then setting the machine back down. The legs should adjust automatically. If they don't, you may need to tilt the machine forward and rap on the rear legs with the handle of a hammer to loosen them–a procedure that's easier to accomplish with a helper.
Your washer has either a painted steel or porcelain-coated steel cabinet. It's perfectly safe to use a little dish detergent and a damp rag to clean all of its surfaces. If the surface is porcelain, you can even use a little non-abrasive cleanser for stubborn stains.
Most washing machines collect lint during the wash cycle and send it down the drain during the drain cycle.
If your machine is a Maytag, though, it may be different. Most Maytag washing machines collect lint in the center tube of the agitator. You need to lift out that tube and clean it periodically. Other machines have a lint filter near the top of the tub, which you need to slide out, clean off, and reinsert.
Courtesy of http://www.repairclinic.com/Washing-Machine-Maintenance-Tips
During the Holiday season appliance usage is in high demand for Ranges, Ovens, and Dishwashers.
Check your oven temperature. Purchase an oven thermometer, and preheat the oven for at least 30 minutes. Then record the highest and lowest temperatures for three cycles. If you have an oven that has a low temperature of 325˚ and a high of 375˚ when the dial is set at 350˚, then your oven is working properly.
If the calibration is off by 25 degrees or more, you may have an oven control, thermostat or sensor problem, requiring replacement parts: Range-Stove-Oven-Parts
Polder 602-90 Digital Cooking Timer/Thermometer and Clock, White
•24 hour countdown timer allows you to time even slow cooking recipes
•Presettable alarm temperature allows for precise cooking
•Timer and thermometer work simultaneously or individually to accommodate various cooking needs
•43″ probe wire for full use of oven cavity
•USDA food temperature chart included
If you refrigerator's ice maker is producing ice cubes that taste bad or smell funny, here are possible causes and solutions:
Possible cause 1: Dirty water filtration system filter.
Solution: Replace it. Refrigerator water filtration system filters should be replaced at least every six months. Depending on usage, you may need to replace yours more frequently. Read your refrigerator owner's manual for instructions specific to your model.
It's a good idea to stock up on filters to save time and money. Enter your refrigerator's model number here to find the manufacturer-recommended filter for your specific model.
Possible cause 2: Stale ice cubes.
If you're not often retrieving ice cubes, it could be that the old ice has absorbed odors from its food neighbors inside of your freezer or refrigerator. Food gases are easily transferred to water and ice. In fact, ice cubes can easily absorb odors from spoiled food inside of your refrigerator's interior compartment.
Solution: Use ice cubes more frequently. Keep your refrigerator and freezer free of spoiled food.
Possible cause 3: Unhealthy water supply.
If your city or well-provided water is full of impurities, minerals, salt or sulfur, your water and in turn, your ice cubes, will have an unfavorable taste and odor.
Possible solutions: Make sure you regularly replace your water filtration system's filter.
If your refrigerator doesn't have a built-in water filtration system or an in-line filter on the water line to your refrigerator, consider this easy-to-install refrigerator water filter kit. It will remove impurities and chemicals to improve water quality and taste.
Hard water may also be affecting the water quality. You can test for water hardness with these water test strips. You may need a water softening system. If you already have one in place, it may be using too much salt. Consult your water softening system owner's manual and adjust settings as needed.
Slight, but important tangent, since we're on the subject of water filtration: Ever hear of reverse osmosis (a.k.a. hyperfiltration) water filtration? It's the process that many water bottling companies use to reduce the amount of impurities and minerals in water. Today, there are such systems available on the market for residential use. However, one should never connect a reverse osmosis filtration system to a refrigerator water supply – due to the possibility of reduced water pressure that can lead to refrigerator problems and expensive repairs.
Possible cause 4: Improperly sealed or unwrapped food inside of your freezer. Fresh and old ice cubes alike will absorb food gases.
Possible solution: Regularly clean out your refrigerator and freezer, tossing out expired foods. Double wrap and bag products with weak packaging (this will also help prevent freezer burn). Use a freezer deodorizer like this one that's specifically designed to combat strong food odors.
We also use a refrigerator deodorizer in our refrigerator compartments, too. According to the manufacturer, this refrigerator deodorizer is 50 times more powerful than baking soda in keeping refrigerators smelling fresh. It lasts up to six months and keeps highly-perishable food like fruits and vegetables fresher longer. Check out additional freezer and refrigerator deodorizers and cleaners here.
Possible cause 5: Food spills or mildew growth inside of the freezer or refrigerator compartments.
Solution: Thoroughly clean the inside of the freezer and refrigerator using a solution of warm water and baking soda. The solution should be about one tablespoon of baking soda to one quart of water. Avoid using cleaning products with harsh chemicals such as bleach or ammonia, as they may damage your refrigerator's interior walls. Check your refrigerator owner's manual for specific instructions related to cleaning and mold removal.
Related info
How to speed up your ice maker & get ice faster
Three quick fixes for broken ice makers
Something broken? RepairClinic has free troubleshooting and repair help information for refrigerators and ice makers. Please enter your model number here for model-specific repair help and troubleshooting information.


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Does anyone knows an unit test framework for c++? I wll use it on linux...
Does anyone knows an unit test framework for c++? I wll use it on linux...
Search the Web and try out a few until you find one that fits your requirements. At the moment, I default to UnitTest++.
Look up a C++ Reference and learn How To Ask Questions The Smart WayOriginally Posted by Bjarne Stroustrup (2000-10-14)
I wrote my own, then after chatting with a colleague discovered that I had independently re-invented something almost exactly like some other unit test framework. Something Lite I think it was.
My homepage
Advice: Take only as directed - If symptoms persist, please see your debugger
Linus Torvalds: "But it clearly is the only right way. The fact that everybody else does it some other way only means that they are wrong"
I like Boost.Test a lot. But I wouldn't recommend its use without also using Boost.Build as the build system.
All the buzzt!
"There is not now, nor has there ever been, nor will there ever be, any programming language in which it is the least bit difficult to write bad code."
- Flon's Law
I really fell in love with CxxTest User's Guide because it's extremely lightweight and in opposite to most other frameworks very less "overhead code" is required to create tests. It accomplishes this using perl for an own preprocessor-like system, so a perl installation is required. for windows I recommend ActivePerl


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A new Tax Court case appears to create a blueprint for passing assets to heirs through a family limited partnership (FLP).
Alert: The new case upholds a formula clause for valuing the FLP interests passed to other family members. (Wandry, TC Memo 2012-88) The IRS has sometimes successfully challenged such clauses in the courts, but this time the Tax Court sided with the taxpayers.
However, the Wandry case is only a Tax Court Memorandum opinion. The IRS may yet appeal the decision or Congress could shoot down the technique. Until then, it's fair game.
Here's the whole story: When you set up an FLP, you transfer assets, typically interests in a closely held business or investment real estate, to a limited partnership. You may act as the general partner while other family members, such as adult children, are named as limited partners. The older generation then gives shares to younger family members like grandchildren.
Although ...(register to read more)
To read the rest of this article you must first register with your email address.


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Housing Bubble & Net Zero Energy Bldg. & Green Nat'l Guard
DPR Construction has built a net-zero energy consumption building for its Phoenix Regional Office--the second and largest in the U.S. The National Guard's former Sustainability program manager and will discuss the Guard's effort to go green. Housing prices in Maricopa and Pinal Counties are up 30 percent from last year, but a local housing expert doesn't see a housing bubble on the horizon.
Aired: 06/10/13Video has closed captioning.


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MRC Upper Blade Gear
This item is discontinued and no longer available for purchase. You may want to search our site for a similar item.
|Low Price:
Discontinued Online
This is a replacement MRC Upper Blade Gear, and is intended for use with the MRC Hoot electric coaxial helicopter. This gear is used to transfer power to the upper blades.
This product was added to our catalog on October 16, 2012.


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Walgreens 7 Days of Photo deals continues and today is a good one: 20 Free Prints! My mother in law just asked me for some new photos of the kids to add to her collection, so I've been waiting for this one! Here's what's on tap for the rest of the week: 4/8 – Thursday: 80% off Collage Prints 4/9 …Read More »
Home » Tag Archives: 5×7 prints


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Date Night Presents Ten Great Movie Chases
We all love the suspense of a good chase scene. Over the years there have been some pretty spectacular sequences that have left us gripping the edge of our seats. Tina Fey and Steve Carell even endured some horrific circumstances and made it out alive in the upcoming release of Date Night, which hits stores on Blu-ray and DVD August 10! What other famous chase scenes get the adrenaline pumping? Here are ten that fit the bill. (Note: this is NOT the ten best, just ten we really like.)
Steve McQueen fronts this iconic chase scene as "Cooler King" Hilts, a POW determined to escape from the prison where he is being held. After stealing a German motorcycle, Hilts escapes the prison by vaulting the bike over the six-foot barbed-wire fence.
In this intense chase New York detective Jimmy "Popeye" Dole (Gene Hackman) is in hot pursuit of a suspected drug dealer who has hijacked an elevated subway train. Driving a 1971 Pontiac Le Mans, Doyle races against time to catch the train, colliding with cars and dodging civilians along the way.
Indy is no stranger to a chase or two. In this desert scene, he races after a speeding truck. After reaching the vehicle on horseback, he jumps into the passenger seat and kicks out the guard and Nazi driver onto the road. Indy must now shake off the other guards who are in hot pursuit of his truck.
Perhaps one of the most memorable car chases in film history, Thelma (Geena Davis) and Louise (Susan Sarandon) recklessly drive their 1966 Ford Thunderbird convertible while being pursued for killing a rapist. Headed for Mexico, they drive around the southwestern desert before the film's final scene which sees them kiss, hold hands and sail over the edge of the Grand Canyon.
After falling into the hands of toy destroying Sid Phillips, Woody and Buzz must put their differences aside and return to Andy before he moves house. With the help of slinky dog and a remote controlled car, the toys race against the clock to catch up with Andy. After slinky is stretched to his limit and the batteries run flat on the car, it's up to Buzz's rocket to save the day and get the toys back to where they belong – with Andy.
Leaving you on the edge of your seat throughout, Lola must race against time to save her boyfriend from death. He has carelessly lost 100,000 Deutschmarks on the subway, leaving Lola just twenty minutes to raise all the money and save the day.
A whopping twelve minutes long, this 100 mph chase sequence pits the evil albino twins versus Trinity, Morpheus and The Key Maker, and leaves viewers breathless. Jumping from one moving car to the next and leaving cars overturned, the trio must escape the twins. With their tires shot flat, a Ducati 996 motorcycle is their only form of escape.
Having got himself in another spot of bother, lovable rogue Captain Jack Sparrow (played by Johnny Depp) manages to get on the wrong side of some angry Native Americans and is chased through shallow shore water. A close call, he manages to grab onto his departing ship The Black Pearl just in the nick of time.
This odd-ball comedy sees super-geeks Seth, Evan and Fogell running from the cops to escape arrest and attend a high school party. Armed with laundry detergent bottles filled with alcohol, the boys are chased through people's backyards with hilarious consequences. Comedy favorites Jonah Hill and Michael Cera star.
After being mistaken for a couple who have stolen a flash drive from mobster Joe Miletto, Phil and Claire Foster (Steve Carell and Tina Fey) embark on a hilarious night to remember. Chased around New York City by Miletto's sidekicks Collins and Armstrong, the film provides a laugh a minute as the couple attempt to shake off the baddies and find the people that they have been mistaken for.


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Go to: Commentary Games Players Photos tsh Reports Standings
Back to NSC 2011 Home Page
NSC 2011 Live Coverage
[ ]
The 2011 National SCRABBLE Championship takes place August 6-10, 2011 at the Hotel InterContinental Dallas.
The links above take you to our live coverage, updated regularly throughout the event. Reporter Sherrie Saint John writes the Commentary and takes the Photos. Dee Segrest and Kate Watson sit by Board 1 (and sometimes Board 2) each round and post the Games play by play. Our Data Entry Team tabulates scores and runs John Chew's software to generate personal record pages for each of the Players, round-by-round Standings and more detailed reports created by the tsh tournament management program, such as the Scoreboard. Click on the Prizewinners link at left to see a table of prizewinners.
HASBRO is the owner of the registered SCRABBLE® trademark in the United States and Canada. © $year HASBRO. All rights reserved. "SCRABBLE® Brand Crossword Game" is the proper way to refer to this unique group of word games and related properties marketed by HASBRO. "SCRABBLE®" is not a generic term. To use it as such is not only misleading but also does injustice to the company responsible for the trademark's longtime popularity. All we ask is that when you mean SCRABBLE® Brand Crossword Game, you say so.
The SCRABBLE® trademark is owned by J.W. Spear and Sons, PLC, a subsidiary of Mattel, Inc. outside of the United States and Canada.
For more information about SCRABBLE®
or the NSA, or to comment on or correct the contents of this page,
please e-mail:
To report technical difficulties in reading this page, please contact webmaster John Chew at: email@example.com


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11|20|2009 03:59 pm EDT
3 Charged With Comcast.net Hijacking at Network Solutions
Three hackers — Christopher Allen Lewis, 19, James Robert Black Jr., 20, and Michael Paul Lebel, 28 — have been hit with a federal conspiracy charge this week due to their involvement in the 2008 hijacking of Comcast.net – a prank that took down the cable company's homepage and email service for more than five hours and supposedly cost the company over $128,000.
According to the indictment, the hackers gained control of the Comcast.net domain along with 200 other domains with two phone calls to Network Solutions, the company's domain registrar, as well as one email sent from a hacked Comcast email account.
This gave them entry to the Network Solutions control panel for all of Comcast's domains.
Then, after changing the contact information for Comcast.net, the hackers phoned Comcast's original technical contact to tell him what they'd done. When the Comcast manager scoffed at their claims, the hackers decided to take it a step further and redirect the site's traffic to servers that were under their control.
The hackers are being charged under the US. Code for fraud and related activity in connection with computers.
"I wish I was a minor right now," said hacker James Robert Black Jr., "because this is going to be really bad."
4 Comments
November 21, 2009 @ 8:30 am EDT
Social comments and analytics for this post…
This post was mentioned on Twitter by domainnamenews: #domains: 3 Charged With Comcast.net Hijacking at Network Solutions http://bit.ly/070N7rs…
November 22, 2009 @ 12:28 pm EDT
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November 22, 2009 @ 8:05 pm EDT
Hijacking a domain name is pretty simple, all it takes is photoshop, a fake drivers license, a fax business license, and a fax machine. I have worked for a few domain companies over the years and they are all about the same as far as security and it don't take much to gain control over someones domain. Obviously getting control over the Comcast name would probably take a bit more effort, but I have seen it done with fake papers from a lawyer. They were just stupid and got caught.
November 28, 2009 @ 6:44 pm EDT
Thank you in advance for your quick answer !. Very nice post.
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Issue No. 05 - May (1984 vol. 6)
pp: 639-645
Chul E. Kim , Department of Computer Science, Washington State University, Pullman, WA 99164.
Definitions of 3-D digital surface and plane are introduced. Many geometric properties of these objects are examined. In particular, it is shown that digital convexity is neither a necessary nor a sufficient condition for a digital surface element to be a convex digital plane element, but it is both necessary and sufficient for a digital surface to be a digital plane. Also algorithms are presented to determine whether or not a finite set of digital points is a (convex) digital plane element.
Chul E. Kim, "Three-Dimensional Digital Planes", IEEE Transactions on Pattern Analysis & Machine Intelligence, vol. 6, no. , pp. 639-645, May 1984, doi:10.1109/TPAMI.1984.4767578


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CORALVILLE, Iowa, Dec. 29 (UPI) -- Republican presidential hopeful Rick Santorum said Thursday he has a stronger record than his competitors of winning elections in "tough states."
Santorum, a former Pennsylvania U.S. senator, placed third in a CNN/Time/ORC poll of GOP Iowa caucus participants. He moved ahead of rival Newt Gingrich, but remains behind front-runner Mitt Romney and Ron Paul.
Santorum -- who was defeated in his bid for re-election to the Senate in 2006, losing by about 20 points to Democratic nominee Bob Casey -- said previous campaigns, in which he defeated incumbent Democrats, show he can win big races.
"I'm the only one in this race that has a track record of winning elections in tough states," Santorum told NBC's "Today" show, speaking from Coralville, Iowa. "I have to think that's one of the reasons that people in Iowa are looking at us and saying, 'Wow, this guy has defeated, straight up, two Democratic incumbents in very tough districts and in a very tough state.'"
Santorum said he believes he has the staying power his competitors lack.
"I've been through this grind before," he said. "I've run several tough statewide elections with national implications and have had the national media crawling all over my record for years and years and years.
"This has been different than everyone else that's sort of risen in this race, that they haven't been tested and we have. People know there's authenticity here, and they can trust me in what I say (is what) I'm going to do."


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Decision makers
- Michelle WaiteAssistant to the Chancellor
- William NunezAssociate to the Chancellor
- Beth BirnsthihlAssociate Dean & Associate Director, UNL Extension Division
- Elbert DickeyDean & Director, UNL Extension Division
- Debora HamernikAssociate Dean & Associate Director
- Marjorie KostelnikDean
- Linda TempelFaculty & Staff Development Coordinator
- David JacksonAssociate Dean
- Larry BergerDepartment Head, Animal Science
- Steve WallerDean, College of Agricultural Sciences & Natural Research
- Alan MoellerAssistant Vice Chancellor
- Harvey PerlmanChancellor
- Ronnie GreenVice President of Agriculture
- Don Wilhitedirector, school of natural resources
- Stephen Vantasselwildlife damage project coordinator
- Aaron Hildrethproject technician
- Scott Hygnstromvertebrate pest specialist
- ZB MayoInterim Assistant Vice Chancellor for Research
- David HardinDepartment Head, School of Veterinary Medicine & Biomedical Science
- Susan FritzInterim Dean & Director, Agricultural Research Division
Tell University Of Nebraska-Lincoln Extension Shooting Cats is Not Humane
The University of Nebraska-Lincoln Extension has published a document entitled: Feral Cats and Their Management. Instead of embracing humane measures that work, Scott Hygnstrom, vertebrate pest specialist, Stephen Vantasssel, wildlife damage project coordinator, and Aaron Hildreth, project technician published a "how to" guide for killing cats. Their statements are not supported by the existing academic literature or experiences of municipalities across the country.
The bottom line is that the University of Nebraska should not be advocating shooting cats. Cats are pets, not pests as the University contends. In many states, killing cats is considered aggravated cruelty and is a felony.
Please let the University know that pet lovers across the country are outraged by the pseudoscience involved in this report.
Ask the University to retract the report and remove it from their website.
- Assistant to the Chancellor
Michelle Waite
- Associate to the Chancellor
William Nunez
- Associate Dean & Associate Director, UNL Extension Division
Beth Birnsthihl
- Dean & Director, UNL Extension Division
Elbert Dickey
- Associate Dean & Associate Director
Debora Hamernik
- Dean
Marjorie Kostelnik
- Faculty & Staff Development Coordinator
Linda Tempel
- Associate Dean
David Jackson
- Department Head, Animal Science
Larry Berger
- Dean, College of Agricultural Sciences & Natural Research
Steve Waller
- Assistant Vice Chancellor
Alan Moeller
- Chancellor
Harvey Perlman
- Vice President of Agriculture
Ronnie Green
- director, school of natural resources
Don Wilhite
- wildlife damage project coordinator
Stephen Vantassel
- project technician
Aaron Hildreth
- vertebrate pest specialist
Scott Hygnstrom
- Interim Assistant Vice Chancellor for Research
ZB Mayo
- Department Head, School of Veterinary Medicine & Biomedical Science
David Hardin
- Interim Dean & Director, Agricultural Research Division
Susan Fritz
I am outraged at the University of Nebraska-Lincoln Extension's published report entitled "Feral Cats and Their Management." The report uses psuedo-science to adovocate for the wholesale destruction of free-roaming cats.
According to Dr. Frank McMillian, DVMA, ACVIM, of Best Friends Animal Society, the circular uses every known propaganda technique in discussing the issues. It even labels cats as "pests."
It is unconscionable that three pages of the University's document goes into great detail about how to kill cats, including shooting a cat between its eyes, using padded jaw foothold traps, chemical injection, and asphyixiation. In many states, many of these inhumane methods would be considered aggravated cruelty and the perpetrator could be charged with a felony.
I urge you to retract this report and remove it from your website. Cats are pets not pests. I expect more than a biased report from the University of Nebraska.
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But Can It Find the Perfect Parking Spot, Too?
The concept of a car that drives itself is thrilling to some, disquieting to others. But it's no longer preposterous.
By the middle years of this decade, several auto makers could offer technology to make vehicles capable of piloting themselves under certain conditions without the direct participation of the driver.
The auto industry has intensified its research on how to link cruise control, steering, brakes and the cameras and sensors used for collision-avoidance systems into an integrated system able to guide a car safely.
Cars that can "see" the road, sense potential dangers and steer, brake and control speed automatically could ease the drudgery of stop-and-go traffic or long drives, and prevent many accidents caused by drowsy, inattentive or impaired drivers. But that optimistic view would sour if consumers came to distrust the technology's reliability, or suspect that the real goal is to give control of their car to someone else, such as a government agency.
The autonomous car idea got a boost in 2010 when Google Inc. disclosed its effort to perfect the technology. Google's fleet of about eight cars uses sophisticated sensors and the company's mapping data to locate the car precisely and plot a route.
"We want to improve the quality of driving," says Anthony Levandowski, the project manager for Google's self-driving-car effort. Still, Google doesn't yet know exactly "what the business model is for a return on investment," he says.
National Highway Traffic Safety Administration officials have shown interest in autonomous-driving technology and the agency is planning research to better understand the potential safety benefits. Nevada has passed a law allowing autonomous vehicles to operate on its roads, and California is considering similar legislation.
Here are five things to know about the self-driving car phenomenon:
Safety Is Just One Goal
Proponents of autonomous-car technology say that, once perfected, it will be safer and less error-prone than human drivers, and will help reduce the more than one million deaths each year world-wide related to auto wrecks.
As car makers have equipped vehicles with air bags, stability-control systems, computer-assisted antiskid brakes and more crashworthy body designs, traffic-safety regulators have shifted their focus to driver behavior—and various ways to control it. Among the risks of trying to minimize the driver's role are that motorists will reject the technology.
Autonomous-driving backers cite other benefits. "If you free an hour of commuting time, that's productivity," says Nady Boules, director of the electronics and controls integration lab in General Motors Co.'s research and development department.
Google executives have talked about autonomous cars as a way to encourage car sharing, since a user could quickly and easily summon one.
Building on What's Out There
Auto-industry officials say they will take a measured approach to introducing autonomous driving to the mass market, building on technology that's already available and familiar.
GM's Cadillac brand has demonstrated a feature called "Super Cruise," which would allow a vehicle to drive itself on a highway, automatically adjusting speed, staying in a lane and avoiding other cars. That technology is still in testing, but the brand will offer models this year equipped with "driver-assist" features, such as "full range adaptive cruise control" that will slow the car to a stop if a vehicle ahead stops.
Christian Schumacher, director of engineering systems and technology for Continental AG's North American automotive unit, says his company is working on a system it calls "Traffic Jam Assist" that would link the car's cruise control, lane-keeping system, steering and brakes to allow the car to pilot itself at speeds below about 35 miles per hour.
Google's approach is different, says Mr. Levandowski. "If you had the ability to invent a car from scratch today," he says, "you would probably design it differently." Proving the reliability of a fully autonomous system is Google's main goal, he says.
Trust is Critical
Building a car that can drive itself won't be enough, engineers say. The bigger challenge will be getting consumers to trust the technology.
"Are we going to let computers run our lives, and especially our cars?" Ford Motor Co. engineer Jim McBride asked, taking the point of view of customers during a discussion of robotic driving earlier this month at the University of Michigan.
Mr. McBride said customers have come to accept some driver-assistance features that effectively put computers in charge.
But he noted that human drivers, on average, will travel 70 million miles before being involved in a fatal car wreck. That's a challenging reliability target for self-driving car systems. Google's cars so far have logged about 200,000 miles.
Technology Isn't the Obstacle
Liability concerns "could be an incredible barrier" to autonomous cars, says Gary Marchant, a law professor at Arizona State University in Tempe. By offering a fully self-driving car, auto makers could be assuming the risks if—or when—one of the cars gets in a serious accident.
Among the possible solutions, he says, would be legislation shielding auto makers from state liability claims, or arrangements in which car makers pay more for liability insurance, passing on the costs to car buyers with the understanding that insurers will charge them less because their self-driving cars are safer.
Dorothy Glancy a law professor at Santa Clara University in California, says legal complications make it unlikely that self-driving cars could provide independent mobility for people whose disabilities make it impossible for them to drive now. "It's kind of an illusion that they'll be able to drive themselves by themselves to a doctor appointment," she says.
Saving the Romance of the Road
If every car is a pod that guides itself from Point A to Point B at a predetermined speed, on a set route, fewer people might feel the emotional tug required to spend $70,000 on a high performance luxury sedan. That's not what car makers want.
"A car is not an appliance," says Don Butler, vice president of Cadillac marketing. "We are not just a node in the network. I want people to enjoy the vehicle."
Filip Brabec, product-planning manager for Audi's U.S. operation, says the purpose of self-driving technology is to relieve the driver of mundane tasks. He says the company is working on systems that could automate driving in slow traffic, including systems that can read traffic signs. Half of the buyers of its A8 sedan already order a package of systems including radar-enabled cruise control and brakes that engage when the car senses a coming collision.
"Then, when you want to have fun and drive," he says, "we want you to be able to drive the car."
Write to Joseph B. White at email@example.com


text:
|Amazon.co.uk and The Children of Hurin
Subject: Amazon.co.uk and The Children of Hurin
by Urulöké on 2006/11/6 16:40:28
So, if you go look at Amazon.co.uk and search for 'Childred of Hurin', you will get three hardcover matches.
(Not sure if this link will work, but... try it here)
One has ISBN 0007252234 and is £0.80 each (?!) (This is the ISBN for the deluxe edition)
One has ISBN 0007246226 and is £18.04 each
One has ISBN 0007252250 and is £0.20 each (!!?) with a pub date of September
Last one has ISBN 0618894640 (This is the Houghton Mifflin edition marked for import to UK) for £12.59 each.


text:
Release Date: May 18th, 2009
R|1 hr 31 min
Plot Summary
A who's who of early 1980s British comedy and music celebrities performs a benefit for the English wing of Amnesty International. The eclectic stage performance was directed by actor John Cleese, who also appears in several skits with his former fellow Monty Python members. Musical acts include reunited ex-Yardbird members Eric Clapton and Jeff Beck, as well as Sting, Pete Townshend and others. The comedy line-up includes Rowan Atkinson, Barry Humphries and Alexei Sayle.
Cast: Monty Python
Director: Julien Temple, Roger Graef
Genres: Comedy
Keywords: 1980s, Sacrifice, Inspiring, London, Heartwarming
More on Wikipedia


text:
Malekasino Dondolo
- Artist: Fap
- Format: CD
- Release Date: 8/15/2006
|your cart is empty
| suggestive | minimal | beautiful | crackling | noisy | fragile | ambient | Fap is a music collective that tries to use anything to make interesting music. Add a bunch of computers to the mix and you've got a player piano that goes by the old saying 'sticks and stones may break my bones but will that actually sound interesting?' Just as Fap have nothing to say as to the meaning of their name -- is it an acronym, a verb or the sound made when shooting fireworks at the beach? -- they're not very talkative about their music, motives, motifs or their inspiration. Fap make sound so you won't have to. Pasta anyone? IMPORTANT: THIS IS NOT A CD RELEASE, THIS IS A VINYL RELEASE ONLY. CD BABY CARRY NO CD VERSIONS OF THIS ALBUM. THIS IS ONLY AVAILABLE ON LP/VINYL.


text:
GnomeICU (previously GtkICQ) is an Internet based communications
program which makes use of ICQ protocol. GnomeICU also makes use of
Gnome2, a growingly popular desktop environment. GnomeICU is released
under the GNU Public License, and is available free of charge.
WWW: http://gnomeicu.sourceforge.net
Jacques Vidrine <email@example.com>
No installation instructions: this port has been deleted.
The package name of this deleted port was: gnomeicu2
PKGNAME: gnomeicu2
distinfo: There is no distinfo for this port.
NOTE: FreshPorts displays only information on required and default dependencies. Optional dependencies are not covered.
No options to configure
Number of commits found: 28
Move instant messaging related ports to newly created net-im category:
net/gaim -> net-im/gaim
net/gaim-latex -> net-im/gaim-latex
net/gaim-openq -> net-im/gaim-openq
net/gaim-rss-reader -> net-im/gaim-rss-reader
net/gicq -> net-im/gicq
net/gnomeicu2 -> net-im/gnomeicu2
net/gossip -> net-im/gossip
net/ickle -> net-im/ickle
net/jabber -> net-im/jabber
net/jabber-aim -> net-im/jabber-aim
net/jabber-conference -> net-im/jabber-conference
net/jabber-jud -> net-im/jabber-jud
net/jabber-msn -> net-im/jabber-msn
Bump PORTREVISION to chase the glib20 shared library update.
Bump PORTREVISION to chase the glib20 shared lib version change.
Fix a crash that can occur with an improperly formatted history file.
Submitted by: kostik <firstname.lastname@example.com>
Use new GCONF_SCHEMAS.
Approved by: pav
Use new INSTALLS_OMF.
Approved by: bland, kwm, marcus and pav
Bump PORTREVISIONS for all ports that depend on atk or pango to ease in the
big upgrade.
Use the new GConf handling policy, this will be required for GNOME 2.7/2.8 or
those ports will not work. Please see the more detail about this:
Also, please check http://www.freebsd.org/gnome/docs/porting.html for the
update about gconf, gconf.pl script and etc.
Approved by: marcus (portmgr hat)
Reviewed by: My team, FreeBSD GNOME Team
Actually commit the version bump to 0.99.5.
Update to 0.99.5.
Chase the glib20 update, and bump all affected ports' PORTREVISIONs.
- Add SIZE to GNOME ports
Submitted by: trevor
Whoa there, boy, that's a mighty big commit y'all have there...
Begin autotools sanitization sequence by requiring ports to explicitly
specify which version of {libtool,autoconf,automake} they need, erasing
the concept of a "system default".
For ports-in-waiting:
Ports attempting to use the old style system after June 1st 2004 will be
sorely disappointed.
Bump PORTREVISION on all ports that depend on gettext to aid with upgrading.
(Part 1)
USE_REINPLACE must be defined before REINPLACE_CMD may be used.
Remove REINPLACE commands that were rolled into gnomehack.
Convert to new GNOME infrastructure.
Remove USE_GNOMENG.
Update to 0.99.
* Change gnet dependency to gnet-glib2 which should fix some crashes users
were reporting
* De-pkg-comment
Gratuitous PORTREVISION bumps to handle implicit dependencies.
Properly handle OMF files.
chase gdbm lib version
Update to 0.98.126.
The last commit should also have read:
Submitted by: Erik Greenwald <email@example.com>
Fix build on -CURRENT.
Add missing dependency on gnomepanel.
Submitted by: bento
Add gnomeicu2 --> ports/net/gnomeicu2, repo-copied from ports/net/gnomeicu
and update it to version 0.9.111.
Prompted by: Kosta K <email@example.com>
Servers and bandwidth provided byNew York Internet, SuperNews, and RootBSD
No vulnerabilities have been reported in the past 14 days
* - modified, not new
All vulnerabilities


text:
Bailed out, the bankers who succeeded after baling out
Banks backed by the taxpayer may have cut their bonus pots, but staff who left after the catastrophic losses of 2007-10 have found riches elsewhere. Sarfraz Thind looks at where they are now
Brian Crowe is something of an exception. The former chief executive of Royal Bank of Scotland's global banking and markets division turned his back on Mammon and is now an ordained priest.
Most of his counterparts have chosen to maintain a less celestial route. Symon Drake-Brockman, the global head of debt markets, left RBS in February 2009, days before the bank announced a £24.1 billion loss, the biggest in British corporate history.
By the end of the year, he had been appointed to the board of Nexus, an Australian energy explorer, and in 2011 became the executive chairman of Zoltav, a gas and oil explorer that is 40 per cent-owned by Roman Abramovich's son, Arkady. Last year he set up Pemberton Capital, a private equity…


text:
Tilt your heads toward the sky this summer and catch an amazing show above Long Island. Stargazing Nights at Jones Beach State Park is your chance to see the beautiful stars and planets up close. Hosted by New York State Parks and the Amateur Observers Society, you can use their telescopes (or bring your own) to learn about the incredible solar system. Gaze upon the Milky Way, discover ancient constellations, and check out distant planets as you listen to the waves roll in along the beach. Local experts will be on hand to answer any questions you might have. It's a magical experience that the whole family will love. The summer sky comes to life right before your eyes!
Jones Beach State Park is only a 20-minute drive from our boutique accommodations in Woodbury, NY. Enjoy dinner at Volpe Restaurant & Lounge at our hotel or choose from one of the fine restaurants nearby before heading out on your astronomy adventure.
Stargazing Nights at Jones Beach State Park take place every Thursday evening through August 25th. Registration is required, and you can call (516) 780-3295 to sign up you and your family. The cost is $4.00 per adult and children (3 to 17), while kids under 3 are free.


text:
Here at Review Centre we work hard to make sure we are the best place on the internet for honest, unbiased consumer reviews - we are grateful for your help in keeping us that way!
Written on: 10/07/2013
I placed an order at 1 pm Eastern time for my mom in California and she received them the same day at 1:05 pacific time! I don't know of any other florist delivery company that can do that!


text:
The Chauvet COLORdash Batten Tri Lighting Effect features a row of calibrated tri-color LEDs that can be programmed to perform complex pixel mapping and intricate runway effects. Highly versatile and camera-ready, the COLORdash Batten Tri also excels as a surface wash or foot/batten light. Multicolored shadows are not an issue thanks to special optics that blend colors before the light leaves this Chauvet lighting fixture.
Chauvet COLORdash Batten Tri Lighting Effect Features
What started as a simple string and pedal sales catalog has grown exponentially over the past thirty years. The early days were a time where catalogs didn't have much of a presence in the industry, but what began as a college dorm room operation grew rapidly. In 1986 we moved to a full product offering and 64-page catalog, which over the years has grown to 162 pages. Join the AMS family and get your free catalog now!
Copyright © 1996-2017 American Musical Supply, Inc. All rights reserved. American Musical Supply reserves the right to correct pricing and/or product specifications in the event of typographical errors found in our print catalog or on our website. If a product is listed at an incorrect price due to such errors or because of inaccurate information received from a supplier, American Musical Supply shall have the right to refuse or cancel any orders placed, whether or not the order has been confirmed and your credit card charged. If your credit card has already been charged for the purchase and your order is canceled, American Musical Supply will issue a credit to your credit card account in the amount of the charge.


text:
To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile produced by long-term CR (LTCR), using Affymetrix microarrays. We have shown that CR initiated late in life begins to extend lifespan, reduce cancer as a cause of death, and reproduce approximately three-quarters of the genomic effects of LTCR in 8 wk (CR8). Eight weeks of metformin treatment was superior to CR8 at reproducing LTCR-like gene expression changes, maintaining a superior number of such changes over a broad range of statistical stringencies, and producing more Gene Ontology terms overlapping those produced by LTCR. Consistent with these results, metformin has been shown to reduce cancer incidence in mice and humans. Phenformin, a chemical cousin of metformin, extends lifespan and reduces tumor incidence in mice. Taken together, these results indicate that gene expression biomarkers can be used to identify promising candidate CR mimetics.
- drug discovery
- gene expression biomarkers
- metformin
- life span
- longevity therapeutics
a major goal of pharmaceutical research has been to reduce morbidity and delay mortality in the elderly. However, there are presently no authentic longevity pharmaceuticals. The reason none have been found is that no assay has existed for rapidly identifying such drugs. It is unlikely that human trials of potentially lifespan-extending pharmaceuticals will ever be conducted using death as the endpoint. Nevertheless, it appears likely that such pharmaceuticals could be developed or may already exist. Most therapeutics for human diseases were discovered using surrogate assays, with little or no knowledge of the molecular mechanisms of the disease.
We know that lifespan can be extended in experimental mammals by at least two interventions, and they are additive in their effects. Caloric restriction (CR) is a nutritional intervention capable of consistently and dramatically extending lifespan and reducing the incidence and severity of most age-related diseases, including cancer, whether it is initiated in young or older mice (10, 35). In addition, genetic ablation of growth hormone (GH) or its receptor or insulin-like growth factor I (IGF-I) or its receptor produces a dwarf phenotype and extends the lifespan of rodents (5). Such mutations are thought to slow aging because they postpone the age-related development of neoplastic diseases, immune system decline, and collagen cross-linking (5). CR and the Ames dwarf mutation act together to additively change gene expression and increase the lifespan of mice (6). Other long-lived mouse mutants have been identified, suggesting that additional, potentially druggable genetic pathways exist for ameliorating age-related diseases and extending lifespan (31, 32).
The development of assays useful in the discovery of drugs capable of extending lifespan has proven problematic. Lifespan studies conducted in "short-lived" mammals such as mice might appear useful. However, a vigorous mouse strain lives ∼40 mo. In addition, large groups of animals are required for such studies, making the assays too costly and time consuming to be practical. Use of enfeebled rodent strains introduces confounds into such studies and has not been helpful in identifying authentic longevity medicaments.
A number of lines of evidence, including nonhuman primate and human studies, suggest that CR-like processes may be involved in determining human longevity (39, 52). Thus the molecular mechanisms responsible for life- and healthspan extension in animals may also have applications in human health. Many gerontologists have assumed that a CR mimetic drug would need to be administered over an animal's lifetime to resist incremental, age-related changes in physiology and gene expression. However, we recently showed that CR initiated in older mice begins within just 8 wk to extend lifespan and shift the expression of hepatic and heart genes toward the "slow-aging profile" associated with long-term CR (LTCR; Refs. 10, 11, 44). CR initially reduced deaths from tumors by 3.1-fold (10). Approximately 75% of these tumors are liver tumors (44). For these reasons, we focused the studies reported here on liver gene expression.
The data reviewed above suggest that relatively brief treatments with a CR mimetic drug should be capable of shifting the rate of aging and gene expression toward that of LTCR. This introduces the possibility that potential CR mimetics can be rapidly screened using microarray profiling as a surrogate for their effects on lifespan and health. To test this hypothesis, we evaluated the effectiveness of five potential CR mimetics at reproducing the gene expression profiles of CR in mouse liver, using Affymetrix microarrays. Because of the linkage between insulin, IGF-I, and the rate of aging, we tested the effects of the glucoregulatory compounds metformin (MET), glipizide (GLIP), GLIP plus MET (GM), and rosiglitazone (ROS) for their ability to reproduce the effects of LTCR on hepatic gene expression. We also tested soy isoflavone extract (SOY) for its LTCR-like gene expression effects, because it is often touted as a potentially lifespan-extending chemopreventative that is thought to work through mechanisms unrelated to insulin-IGF-I signaling. These data indicate that 8 wk of treatment with MET was even better at reproducing the gene expression effects of LTCR than 8 wk of CR (CR8). These results are consistent with published studies, and together they identify MET as a potential CR mimetic.
Mice and diets.
One-month-old male mice of the long-lived B6C3F1 strain were purchased from Harlan (Indianapolis, IN) and maintained as described after weaning (15). Mice were housed in groups of four per cage and fed a nonpurified diet, PMI Nutrition International Product no. 5001 (Purina Mills, Richmond, IN). At 5 mo of age, the mice were individually housed and randomly assigned to one of two groups, control (CON) or LTCR. CON mice were fed 93 kcal/wk of a defined control diet (AIN-93M, diet no. F05312, BIO-SERV). LTCR mice were fed 52.2 kcal/wk of a defined CR diet (AIN-93M 40% Restricted, diet no. F05314, BIO-SERV). The LTCR mice consumed ∼40% fewer calories than the CON group. The CR diet was enriched so that the CR mice consumed approximately the same amount of protein, vitamins, and minerals per gram of body weight as the CON mice. Animal protocols were approved by the Institutional Animal Care and Use Committee of the University of California, Riverside.
Experimental design.
At 20 mo of age, cohorts of mice in the CON group were randomly assigned to one of seven experimental groups. A CON group continued to be fed 93 kcal/wk of control diet for 8 wk. A CR8 group was fed 77 kcal/wk of CR diet for 2 wk, followed by 52.2 kcal/wk of CR diet for 6 wk. The remaining dietary groups were fed the control diets containing MET (Sigma, St. Louis, MO), GLIP (Sigma), GLIP plus MET (GM), ROS, (Avandia, SmithKline Beecham), or SOY (NOVASOY 400, Life Extension Foundation) for 8 wk at the dosages indicated in Table 1. The drugs were mixed with powdered control diet and cold-pressed into 1-g pellets (BIO-SERV). At 0900, all mice were fed 2/7 of the weekly allotment of food on Monday and Wednesday and 3/7 on Friday. The mice had free access to acidified tap water. They were fasted for 48 h and killed by cervical dislocation at 22–28 mo of age. No signs of pathology were detected in the animals used for the studies reported (n = 4/group). Organs were removed rapidly, flash frozen, and stored in liquid nitrogen. The weights of the mice were monitored biweekly. Mouse weights are given in Table 1.
Drug dosages.
The dosages used for the drugs were chosen to produce a maximal, but not toxic, effect (Table 1). The MET dosage, 187 mg·kg body wt−1·day−1, is in the range used experimentally in chemically and genetically diabetic mice to control blood glucose levels (60–240 mg·kg body wt−1·day−1; Ref. 33). The GLIP dose (93 mg·kg body wt−1·day−1) was in the range used experimentally to control blood glucose levels in diabetic animals (100 mg·kg body wt−1·day−1; Ref. 34). The ROS dose (7 mg·kg body wt−1·day−1) was consistent with that used in other mouse studies (43). The SOY dosage is reported to prevent or reduce the growth of transplanted tumor cells and inhibit the development of chemical- or radiation-induced tumors in mice (36).
Measurement of specific mRNA levels.
Liver total RNA was isolated as described from pathology-free mice (n = 4/group; Ref. 12). mRNA levels were measured using Affymetrix mouse U74Av2 arrays according to standard Affymetrix protocols (Affymetrix).
Probe set expression measurement and normalization.
After hybridization and scanning, raw image files were converted to probe set data (*.CEL files) using Microarray Suite (MAS 5.0). Probe set data from all 32 arrays were simultaneously analyzed with the robust multichip average (RMA) method to generate normalized expression measures for each probe set (Fig. 1; Ref. 28) The data were further filtered to exclude probe data sets that were "Absent" across all 32 arrays according to the MAS 5.0 detection algorithm (1, 53).
Data analyses.
Normalized and filtered data from all groups were analyzed using the significance analysis of microarray (SAM) algorithm (Fig. 1; Ref. 51). Genes that were differentially expressed between two or more groups were identified using multiclass SAM analysis. We set the significance cutoff at a median false discovery rate (FDR) of <5.0%. To determine the specific effects of each treatment on gene expression, each treatment group was separately compared with the CON group using a |1.2|-fold change cutoff (Fig. 1).
Comparison of gene expression changes induced by LTCR and the drug treatments.
To identify gene expression profiles common to drug treatments and LTCR, we used Venn Mapper, which can determine the number of statistically significant changes in gene expression between pairs of treatment groups (42). Venn Mapper reports the number and identity of up- and downregulated genes in the overlap and a table of z-values, where a z-value of 1.96 indicates a P value of 0.05 and a z-value of 2.58 indicates a P value of 0.01. The table of z-values was imported into TreeView for visualization of the z-profile (Fig. 2; Ref. 18).
Functional comparison of gene expression using Gene Ontology terms.
Sequential application of GenMAPP and MAPPFinder was used (9, 17). The Affymetrix probe set IDs, fold changes, and P values from the multiclass SAM and t-test analyses were exported to GenMAPP. The overlapping gene data for each treatment group were color coded and imported into MAPPFinder for global ontology analysis. The criteria for overlapping genes were defined as [(LTCR fold change ≥1.2 AND LTCR P value <0.05) AND (Compound fold change ≥1.2 AND Compound P value <0.05)] for upregulated transcripts and [(LTCR fold change ≤−1.2 AND LTCR P value <0.05) AND (Compound fold change ≤−1.2 AND Compound P value <0.05)] for downregulated transcripts. MAPPFinder linked the expression data of the genes meeting the criterion to the Gene Ontology (GO) hierarchy and assigned a z-score and a P value to each GO biological process, cellular component, and molecular function term. A positive z-score indicates that there are more genes meeting the criterion in a GO term than would be expected by random chance. The P value indicates a significant over- or underrepresentation of genes meeting the criterion for a GO term. The results were further filtered to include only GO terms with z-score ≥2 and P value <0.01 and the percentage of genes meeting the criteria ≥10.
Pathway analyses.
Microarray expression data were imported into PathwayAssist (http://stratagene.com), and all known biological relationships between the differentially expressed genes were graphically identified. PathwayAssist allows the user to query databases and direct the construction and visualization of specific biological interaction networks (BINs). ResNet, the main database used by PathwayAssist, contains molecular networks compiled from the PubMed database by natural language processing.
We administered MET, GLIP, GM, ROS, or SOY to mice, cold packed in their diets for a period of 8 wk. A control group received the diet alone. All these groups were isocaloric, and their weights did not vary significantly before or after the studies (Table 1). The studies also included groups that were LTCR or CR8. The ability of the drugs to reproduce the genomic effects of LTCR was assessed using the criteria described below.
Overlapping responses of CR and the candidate mimetics.
We compared the changed genes identified by multiclass SAM (FDR <5%; Table 2). MET actually produced more LTCR-like gene expression changes than CR8. MET produced 1,776 LTCR-like changes in gene expression, or 75% of the total LTCR-responsive genes. CR8 produced 1,675 LTCR-like changes in gene expression, or 71% of the LTCR-responsive genes. Eight weeks of MET treatment also reproduced 92% of the gene expression changes produced by CR8. The other treatments affected the expression of fewer genes. These results indicate that 8 wk of treatment with CR or MET were highly effective at reproducing the gene expression profile produced by LTCR. MET has been shown to suppress tumorigenesis and/or tumor-related mortality in mice, hamsters, and humans, and CR8 is also effective at delaying tumor-related mortality in mice, including death from liver tumors (see discussion; Refs. 10, 44). Thus these CR8- and MET-responsive genes may have a key role in suppressing tumor-related mortality.
To further statistically quantify the overlap between LTCR and the treatments, the differentially expressed genes were analyzed using t-tests and Venn Mapper (Fig. 1). At a significance of z ≥2, MET and CR8 again yielded the highest number of genes overlapping LTCR (349 and 218, respectively). The other treatments produced fewer such genes [ROS (120 genes), GM (118 genes), GLIP (79 genes), and SOY (15 genes)]. These results again indicate that MET reproduces the effects of LTCR even better than CR8.
To further assess the similarity of the effects of MET, CR8, and LTCR responses, the z-values generated by Venn Mapper were visualized as a heat map (Fig. 2). Examination of the data in this way confirmed that the co-regulated genes were upregulated and downregulated similarly by the treatments. Thus, at a high level of statistical stringency, the gene expression response to MET is highly similar to LTCR, as indicated by both the number of overlapping genes and the direction of their regulation. This overlap is significantly greater than that of any of the other drugs. On the basis of these data, MET appeared to be the most promising candidate CR mimetic.
Comparative analysis of the efficacy of the treatments at increasing fold change cutoffs.
To further explore the similarity between LTCR and the treatments, we determined the number of LTCR-like changes in gene expression at increasing fold change thresholds (Fig. 3). At increasing levels of stringency, MET, followed by CR8, maintained the most overlap with LTCR. Thus, by this metric, MET induced a transcription profile that was more like LTCR than the other treatments, including CR8.
Analysis of the overlap between the treatments at increasing statistical stringency.
The overlap between LTCR and the treatments was also examined by directly increasing the level of statistical stringency (Fig. 4). MET, followed distantly by CR8, maintained the highest number of overlapping genes at increasing z-values. At z ≥22, MET treatment produced ∼300 changed genes, whereas the other treatments, including CR8, produced no changes. Thus, with increasing statistical stringency, MET better duplicated LTCR than did any other treatment, including CR8.
Comparative functional analysis using GO terms.
To further explore the similarities between the treatments and LTCR, we used GenMAPP and MAPPFinder on the output of VennMAPPER to create an unbiased estimate of their overlapping physiological effects. The number of GO terms common to LTCR and the treatments is a quantitative measure of their functional similarity. MET produced the highest number of GO terms overlapping those of LTCR, again outstripping even CR8 (Fig. 5). These results predict substantial physiological similarity between the effects of MET and LTCR.
Effects of GLIP on gene expression are dominant over those of MET.
GLIP is an insulin secretagogue. The major hepatic effects of MET include insulin sensitization, reduction of gluconeogenesis, and enhancement of glucose utilization. Here, we found that administration of GLIP together with MET reduced the number of MET-responsive, LTCR-like changes in gene expression found by multiclass SAM from 3,092 to 718, a 77% reduction (Fig. 6). In contrast, MET reduced the number of LTCR-like changes in gene expression induced by GLIP by about one-half. The reduced number of MET-responsive genes may be the result of GLIP-enhanced insulin secretion, since changes in blood glucose levels per se have few effects on hepatic gene expression (20).
Effects of the treatments on the weights of the mice.
Changes in body weight cannot explain the results obtained here. There was no significant difference in the body weights of the groups (Table 1). Moreover, the drug-treated and control mice consumed the same number of calories. We inspected the cages for any signs of uneaten food before each feeding and found none. The mice assigned to the MET group weighed on average the same as the control mice. Thus the drug-induced microarray profiles result from the treatments themselves.
We investigated the hypothesis that global changes in gene expression identified using high-density microarrays can be used as surrogate biomarkers for the identification of candidate CR mimetics. We tested this hypothesis by screening a number of glucoregulatory pharmaceuticals and a putative chemopreventative for their effects on hepatic gene expression in mice. We found that 8 wk of MET treatment produced a gene expression profile that overlapped LTCR to an even greater extent than the profile produced by 8 wk of CR. We have shown previously that CR begins to enhance lifespan and reduce tumor incidence within 8 wk of its initiation (10). MET matched 75% of the gene expression changes induced by LTCR and 92% of the changes produced by CR8. Thus the analyses described here indicate that MET is a promising candidate CR mimetic.
The homology between the MET and CR profiles is consistent with the similarities in their effects on circulating insulin levels and tissue insulin sensitivity (13, 30). CR lowers blood glucose levels, thereby reducing circulating insulin levels, leading to enhanced tissue insulin sensitivity. MET enhances liver, muscle, and fat insulin sensitivity and reduces hepatic glucose output, leading to lower blood glucose and insulin levels (30). Most of the gene expression effects of CR and MET may be due to reductions in serum insulin levels, since blood glucose levels may not alter hepatic gene expression (20). However, ROS treatment also lowered serum insulin levels by approximately one-half (unpublished results) but did not produce as many CR-like effects on gene expression. These results suggest that additional changes in physiology also may be reflected in the overlapping expression profiles of CR and MET.
Health effects of MET.
LTCR has long been known to reduce the incidence, progression, and growth of cancer, in part by increasing the rate of apoptosis in mitotically competent, and therefore more cancer-prone, tissues (27). Recently, we have shown that CR rapidly reduces the rate of growth (and perhaps onset) of tumors (10). Consistent with the evidence presented here, chronic MET treatment of female transgenic HER-2/neu mice increased their mean lifespan by 8% and their maximum lifespan by 13% (3). It also significantly reduced the incidence and size of mammary adenocarcinomas and increased the mean latency of the tumors. Phenformin, a chemical cousin of MET, extends lifespan of C3H mice by ∼23% while reducing tumor incidence by 80% (2, 16). Further, MET treatment may be associated with reduced cancer risk in patients with type 2 diabetes (19). MET completely protects hamsters fed a high-fat diet from malignant, hyperplastic, and premalignant pancreatic lesions (40). Indirect evidence suggests that signaling through AMP-activated protein kinase may mediate both the anti-diabetic and inhibitory effects of MET on cancer cell growth and division (25). AMP-activated protein kinase may be involved in regulating the lifespan of Caenorhabditis elegans, Drosophila, and yeast (4, 24, 49). MET is also effective in the treatment of polycystic ovary syndrome (26). Finally, MET therapy has been shown to inhibit the development of metabolic syndrome in humans, which is associated with decreased risk of cardiovascular- and diabetes-associated morbidity and mortality (37). Together, these results suggest that microarray biomarkers can be used to identify promising candidate CR mimetics.
Probable function of the MET- and CR-responsive genes.
The above conclusions assume that each of the transcriptional responses to CR are of approximately equal importance to its physiological effects. There are a number of lines of evidence supporting this assumption. First, like many of the genetic mutations known to extend lifespan, CR induces a substantial number of changes in gene expression (32). Most lifespan-extending mutations are in signal transduction-related genes, which regulate batteries of other genes. For example, the Ames dwarf mutation acts additively with LTCR to extend lifespan and change the expression of a substantial number of genes (50). Thus changes in the expression of significant numbers of genes appear to be linked to the lifespan and anti-cancer effects of most or all of the known lifespan interventions. Second, 8 wk of CR is sufficient to initiate its anti-cancer effects in the liver (10). Eight weeks of MET treatment reproduced 75% of the gene expression effects of LTCR and 92% of the effects of CR8 in liver. Furthermore, essentially all of these CR-induced changes were reversed by 8 wk of control feeding. Thus the gene expression effects of LTCR and CR8 are linked temporally to their biological effects. Third, the lifespan extension and anti-disease effects of CR are highly pleiotropic. For example, they clearly differ in liver and heart (10, 11, 44). In concert with these observations, the gene expression changes in liver and heart are different and numerous but easily reconciled with their tissue-specific physiological effects (10, 11, 44). Thus many of the overlapping gene expression effects of MET, LTCR, and CR8 may produce or result from similarities in their physiological effects.
GO terms.
The transcriptional response of the liver to LTCR is well characterized in mice (7, 10, 14, 44, 46, 50). The number of overlapping GO terms produced by the treatments is an unbiased measure of their functional similarity. By this measure, MET and LTCR are more similar functionally than even CR8 and LTCR.
BINs contributing to the CR-mimicking effects of MET.
The co-regulation of genes by LTCR and MET implies that they utilize common transcription factors and upstream effectors. To further elucidate the functional similarities between the treatments and LTCR, we utilized PathwayAssist. Of the 349 genes co-regulated by LTCR and MET, 206 could be mapped to the ResNet database (version 3.0). These genes were used to build BINs using "Common Regulators," "Common Targets," and "Direct Interactions." The major CR- and MET-associated effector pathways identified by Common Regulators included insulin, tumor necrosis factor (TNF), fibroblast growth factor-2, epidermal growth factor, and elements of their related signal transduction pathways, including Fos, Mapk1 and -8, and P53.
Common Targets identified the major cellular processes targeted by the CR-mimicking effects of MET as apoptosis and cell survival, differentiation, cell proliferation, and focal contact. Direct Interactions indicated that the predominant genetic links between LTCR and MET are closely associated with chaperones. The chaperone network was further analyzed using the "Expand Pathway" option. It identified downregulation of the mostly endoplasmic reticulum chaperones TRA1, HSPA5, GRP58, and DNAJB11 and the related transcription factor XBP1 as major features of the CR-mimicking effects of MET. These chaperones are involved in apoptosis, proliferation, differentiation, inflammation, oxidative stress, and other cellular processes.
We previously found that CR negatively regulates endoplasmic reticulum chaperone expression in liver and several other tissues (7, 10, 45, 48, 50). Chaperone overexpression reduces apoptosis and promotes tumorigenesis, while underexpression enhances apoptosis and prevents tumor formation (29, 47). Chaperone overexpression also is associated with the acquisition of resistance to chemotherapeutics and cell-mediated immunity (8, 22, 23, 41, 47). Chaperones can inhibit key effectors of the apoptotic machinery including the apoptosome, the caspase activation complex, and apoptosis-inducing factors (21). For example, HSPA5 (also known as BiP and GRP78) inhibits proapoptotic signaling in part by directly blocking caspase activation (38). These overlapping effects are consistent with the anti-cancer effects of MET and CR.
Other potential regulators of apoptosis and tumorigenesis.
Lifespan extension by CR and disrupted IGF-I signaling is associated with reduced serum insulin levels and increased insulin sensitivity (13). MET is an insulin-sensitizing agent with potent anti-hyperglycemic actions (30). Consistent with these properties, Common Regulators identified insulin as a major regulatory factor in both MET and LTCR action. In addition to its glucoregulatory actions and its effects on energy and lipid metabolism, insulin can also be a mitogen or a regulator of apoptosis. Signaling by insulin and the other effectors discussed above converges on the early growth response-1 (ERG1) gene, which increased expression in CR- and MET-treated mice. Signaling through mitogen-activated protein kinase-1 (MAPK1), MAPK8, FOS, and transformation-related protein 53 (TP53; also known as p53), which were also implicated by Common Regulators in the action of both MET and LTCR, also converges on ERG1. ERG1 is a zinc finger, nuclear localized, positive transcription factor that acts as a tumor suppressor. Thus positive regulation of ERG1 may mediate part of the carcinoprotective effects of CR and MET.
MAPK1 has a central role in the induction of apoptosis in response to various stressors, as does MAPK8, which is required for the cytochrome c-mediated cell death pathway (induced by TNFα and UV radiation). FOS family members are also associated with apoptotic cell death, as well as with proliferation and differentiation. Likewise, TP53, a tumor suppressor, plays an essential role in the regulation of the cell cycle and apoptosis. Regulation by TNF and TP53 converges on caspase 6 (CASP6), which was induced by both MET and LTCR. CASP6 is thought to function downstream in the caspase activation cascade.
According to Common Regulators, epidermal growth factor and nerve growth factor-β (NGFB) regulation converges on programmed cell death 4 and neoplastic transformation inhibitor (PDCD4), which was induced by both LTCR and MET. PDCD4 encodes a nuclear-localized tumor suppressor that appears to play a major role in the regulation of apoptosis. NGFB is also associated with HSPA5 regulation. The potential TNF-mediated induction of IκB kinase-α (CHUK) is another link between LTCR, MET, and apoptosis identified by Common Regulators. CHUK phosphorylates the IκB family, marking them for ubiquitination and degradation, which can lead to the induction of apoptosis. TANK-binding kinase 1 is another NFκB-related gene induced by both LTCR and MET. The protein encoded by this gene is similar to the IκB kinases. It can mediate NFκB activation in response to growth factors by releasing it from inhibition by the IκB proteins TANK and TRAF2. Another proapoptotic effect of LTCR and MET is downregulation of TRAF4, which mediates signal transduction by members of the TNF receptor superfamily. This protein interacts with the neurotrophin receptor, p75 (also known as NTR/NTSR1) and antagonizes NFκB activation and NTR-induced cell death.
In conclusion, the studies described herein show that high-density microarray profiles of gene expression in the liver of LTCR mice can be used to screen compounds and identify potential CR mimetics. These results suggest that drugs capable of reproducing some or all of the life- and healthspan-extending effects of CR may be identified in this manner. They also indicate that MET is a potential CR mimetic.
We thank the Life Extension Foundation for unrestricted gifts in support of this research.
Present addresses: J. M. Dhahbi, BioMarker Pharmaceuticals, Inc., 851 W. Midway Ave., #201A, Alameda, CA 94501; G. M. Fahy, Intervene Biomedical, PO Box 478, Norco, CA 92860.
Article published online before print. See web site for date of publication (http://physiolgenomics.physiology.org).
Address for reprint requests and other correspondence: S. R. Spindler, Dept. of Biochemistry, Univ. of California-Riverside, Riverside, CA 92521 (e-mail: spindler{at}ucr.edu)
- Copyright © 2005 the American Physiological Society


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Pandemic Planning for Academic Institutions
Elizabeth Hosmanek, JD
Program Associate
University of Iowa Hygienic Laboratory & Institute for Public Health Practice
Program Associate
University of Iowa Hygienic Laboratory & Institute for Public Health Practice
This program is co-sponsored by the Upper Midwest Center for Public Health Preparedness, and features Ms. Hosmanek who currently serves as facilitator for the University of Iowa Pandemic Influenza Task Force and also played an instrumental role in the ASPH/CDC Pandemic Influenza Collaborative Group which developed the forthcoming "Pandemic Influenza Preparedness Resource Kit for Academic Institutions." She will share information and resources available to academic institutions to support their pandemic influenza preparedness efforts, and lessons learned during the development and execution of the April 2007 tabletop exercise designed to prompt rapid decision-making and test the current Pandemic Plan at the University of Iowa.
Learning Objectives
- Identify strategies to help plan response for Pan Flu at schools
- Describe isolation and quarantine procedures for Pan Flu
- Identify strategies for communicating with parents and students
Domain 1:
1.3 Facilitate collaboration
1.3 Facilitate collaboration
Domain 3:
3.2 Contribute expertise to the development of emergency plans
3.3 Participate in improving organization's capacities
Public Health Emergency Preparedness Capabilities
Capability 1: Community Preparedness
Capability 4: Emergency Public Info
Capability 11: Non-Pharmaceutical Interventions
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- Institute for Health System Evaluation
- Capital Region Medical Research Institute
- News and Events


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Dear Fans,
The last time I wrote the Final Whistle was after we beat the Revs at PPL Park on a cold, wet, wintry day. Now we are about to go to Foxborough for the second of our three meetings against New England this year; and the seasons have changed. Spring is in the air and to quote U2, we are hoping for a "Beautiful Day"!
What Do You Stand For – It can't be said enough. This team, this staff, this organization - We Stand For You. On Sunday, away from the comfort and familiarity of a young PPL Park and into what I will politely describe as an "elderly" RFK Stadium, you stood for us, once again. As always, the Sons of Ben were loud and boisterous, with their shouts heard clearly on the field, bench and all the way to the ESPN2 broadcast. But when the final whistle blew and I went to find my family in the stands, I was further amazed at how many people there were wearing Union colors inside what would have otherwise been a stadium full of red and black.
From the Sons of Ben being so organized and loud to the other Union supporters who made the trip to D.C., that kind of support in really tough environments is crucial. There's no doubt that the energy in the stands trickles down to the effort on the field. On a day where we made club history – getting our first win at RFK against one of our biggest rivals (the best birthday present my son, Larsen, could ask for) – your support made every bit of difference.
Thank you.
With that said, I'll move into a little bit of where we're at as a team…
This year, our club has already achieved some good things: we were the first team to ever beat Colorado in their home opener; we earned our first point in Columbus; and now, have our first win in D.C. I think these are all really good signs for our team, and I'm really proud of our guys. And yet, I think we are capable of playing better soccer. We can be much better. This past weekend, we took a two goal lead twice in the game, and gave up a two goal lead twice in the game. We put ourselves through all of the emotions and momentum of a game when we're playing against a talented home team, trying to get back in it. In a lot of ways, we did a really good job of managing the game once we gave up the two-goal lead, but at the end of the day, we can still play better soccer to keep ourselves out of those situations to begin with. While we've already put in some really good performances, we know we can improve in many ways.
Right now, our bench is probably the strongest it's ever been, and there are different situations within the game that dictate some of the decisions the coaching staff makes on who to play and who not to play. A prime example of that occurring was this past weekend with Seba. While it is tough for Seba to not play in the match because of the game situation, for us to win at D.C. without him is a really good sign. Another example is Kléberson, who continues to do well and has, in every way, been a very positive influence to our club. But I think that is what a good team is all about – being successful when you are faced with those different selection options.
Additionally, Jack continues to play well, and while he deservedly got a lot of accolades for his performance this week, we have to recognize that our team is doing an excellent job of understanding their roles and responsibilities. Of those to note: Conor's ability to bring his teammates into the game from some really tough situations, allowing us to play off of him; Amobi and Sheanon having two critical blocks in the first half against United; BC, Keon and Michael tactically taking away an important part of the field against D.C.; Danny running tirelessly to stretch the opposing defense, making a big play on the second goal to provide the assist to Conor, and then coming back to help on our defensive side; Zac saving a difficult shot that comes through a crowded box and then holding on to the rebound. All of these little moments are what we call "critical moments." And when we recognize these moments as a team and win the majority of them, which we've been able to do game in and game out, it will continue to put us in a position to be successful.
With all of that said, we have another crucial game on the road this weekend in New England…
On Saturday, our task is to do what we've been doing on the road and that is to go and get points. It's still early in the year and, while we're in a good position, we feel like we can improve game to game and week to week, and this is an opportunity for us to once again prove that we're making positive strides.
Saturday's match will be the first home game NE has played and the first sporting event in Foxborough since the Boston Marathon tragedy. We have some very close relationships with some of the guys from the Revs – Matt Reis, whose father-in-law was critically injured in the bombings and Chris Tierney, whose girlfriend was also injured. Then there is the situation with Kevin Alston, who is battling Leukemia right now. These types of moments in life – the difficult, heartbreaking, hardships – put sports and everything we do in a completely different perspective. Ultimately, sports are really insignificant when compared to our relationships with the people we care about most. What we do is play a game. But at the same time, I think the game we play can serve as a means to bring groups of people together unlike anything else, especially in difficult times like these. Sport becomes a symbol that there are much more important things than the game itself. Within our team, we talk about how blessed we are to be in these positions and how fortunate we are to do something we love. As an organization, we go into this game understanding the emotions that will surround this game and we are humbled by the fact that we get to play in front of fans who share our passion and come together to celebrate something much more important than the game itself.
This weekend as we take on New England, we are united as a larger family – the Union, the Revolution and the soccer community as a whole – through the sport we love, standing together in the face of some really tough circumstances.
Thanks for your continued support.
John Hackworth


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To begin this review, I have to say that I'm a bit of a sucker for pu-erh sold in bird's nest form, just because I think it looks really cool. However, I will attempt to not let this affect the bias of my review. Soooo, without further ado…
The dry tuocha smelled dark, dark and rich. Its very earthy scent had a touch of spicy notes to it as well. Wet, it had spicy and tobacco tones about it.
I chose to infuse this using multiple short infusions of about 30 seconds each.
First infusion: The liquor was still very bright and clear, a light brown in colour. It smelled faintly of the dry tuocha. The taste is very light, and I wonder if 30 seconds is not long enough. It certainly does taste earthy though. It is not as spicy as the smell led me to believe.
Second infusion: This time, the brown liquor deepened and darkened in colour, while maintaining its brightness. The scent is now very earthy, with almost a bit of fishy smell to it. Mmm, the taste has deepened. Full-bodied, the liquor tastes earthy and mellow. It goes down smooth, as though it barely brushes the tongue and throat.
Third infusion: The colour of the tea is now a deep brown, nearing dark chocolate in colour. The aroma has not changed much, but the flavour is much stronger and feels more mature. Very delicious at this point. I am quite enjoying this tea and I wonder how long this tuocha will last.
Fourth infusion: This cup was just as enjoyable as the third and had the same strength and characteristics. It seems as though this tea could certainly continue with more infusions. When I have more time, perhaps I will give one of these tuocha a test of how long it can last.
I loved being able to try this tea as it continued to grow and mature in taste and aroma. I truly cannot wait to drink it again. I rate it an 85/100 on my personal enjoyment scale!


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Feb. 13, 2014
OSU-CHS joins rural health advocacy efforts during NRHA`s Policy Institute
|Amanda Jantz, Matt Haney, Congressman Markwayne Mullin, Mickey Borgsmiller and Alisha
Murrow meet during the National
Rural Health Association Policy Institute.
Members of the Student Osteopathic Rural Medicine (StORM) Club and OSU-CHS administrators and staff met with federal officials during the 25th Annual National Rural Health Association Policy Institute last week in Washington, D.C.
Second-year medical students Amanda Jantz, Matt Haney, Mickey Borgsmiller and Alisha Murrow joined ongoing NRHA advocacy efforts to advocate for rural health policy and legislation. They met with senators, representatives and their staffers to seek their support to protect and strengthen rural Medicare programs, modify the Medicare sequestration process to avoid disproportionate harm to the rural health safety net and increase funding for rural health programs.
William Pettit, D.O., interim senior associate dean for academic affairs and associate dean for rural health, Duane Koehler, D.O., assistant to the dean for rural education, Vicky Pace, director of rural medical education, Nicole Neilson, Southwest regional coordinator, and Cori Kaiser, director of the Oklahoma Office of Rural Health, also participated in advocacy efforts during the institute.


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Sale Alert: Modern Economy First Ever Online Sale
Modern Economy a recurring sale selling samples and overstocked goods of independent designers, which until now has taken place in San Francisco and Los Angeles, will hold its first-ever online sale, giving all of you budget-minded design enthusiasts a piece of the action. The sale will take place on Wednesday, Oct. 8, with "doors" opening at 9:00 a.m. (PDT). To access the sale, go here. The last time Modern Economy came to San Francisco, I returned home with buckets of fab home décor accessories, including potholders by Deadly Squire, pillowcases by Dermond Peterson, ceramic plates by Rae Dunn, and tea towels by Tikoli. I'll definitely be hitting up this affordable modern design sale; maybe I'll see you there.


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Table leaves allow you to update your dining room in minutes. Take leaves out to create an intimate seating arrangement or insert leaves to provide more seating for guests. Change the look of your dining room to accommodate guests no matter the size of the party with the use of extension leaves.
Regale your guests with tales of your latest travels abroad while gathered around this spacious, traditionally-fashioned dinner table. A time-tested construction of hardwood solids and rosewood veneers is sealed in a multi-step Sumatra wood finish, guaranteed to retain its luster and tobacco coloring for years to come. Delicately turned legs are capped with antiqued brass for a touch of ornate adornment. Built to grow with your guest list, this table can be from 80 to 120 inches long with the inclusion of two, 20 inch table leaves. Dining chairs feature natural materials like twisted rattan and leather strapping, perfect for adding a touch of the exotic to your room decor.
The Landara 11 Piece Pelican Hill Dining Set with Palmetto Chairs by Tommy Bahama Home at Becker Furniture World in the Twin Cities, Minneapolis, St. Paul, Minnesota area. Product availability may vary. Contact us for the most current availability on this product.
Natural beauty and the wonders of civilization move you to travel the world. You never sit still, because the sense of awe you feel while experiencing new cultures and landscapes constantly draws you. Whether off on an African safari or the stunning white sand beaches of the West Indies, your life's journey is to see and do it all. When you come home again, you want surroundings that remind you of all the things you've done and mesmerizing places you've been. Your home is undeniably a Landara home.The Landara home collection was Inspired by refined destination travel resorts and features rich and opulent design accents like woven raffia, crushed bamboo, and stunning rosewood veneers. Borrowing from the style of British Campaign furniture, Landara displays beautifully sculpted antique brass hardware and leather strap detailing. From ornately shaped, tropical dining tables to the soaring rattan poster bed, each piece is characterized by distinctive luxury and a subtly exotic feel. Versatile pieces run the gamut from handy storage chests to accent chairs that can fit perfectly into many different room settings. The Landara collection also offers a wide selection of custom fabric upholstery pieces, imbuing your home with relaxation and comfort in addition to breathtaking style. From the ends of the earth to the warm embrace of home, Landara offers the perfect blend of wide-eyed wonder and welcoming comfort.
The Landara collection is a great option if you are looking for Tropical furniture in the Twin Cities, Minneapolis, St. Paul, Minnesota area.
These images are representative of this group as a whole and may differ from this item.
Browse other items in the Landara collection from Becker Furniture World in the Twin Cities, Minneapolis, St. Paul, Minnesota area.
This item has been tagged as: Table, Dining Tables, Table Set, Dining Table Set, Table and Chair Set, Dining Table and Chair Set, Dining Chairs, Chairs, Arm Chair, Dining Arm Chair, Side Chair, Dining Side Chair, Pub Table, Counter Height Table, Bar Table, Pub Table Set, Counter Height Table Set, Bar Table Set, Counter Height Stool, Stool, Bar Stool, Dining Room Furniture, Entertaining Furniture, Furniture Sets, Game Table Set, Gaming Tables, Kitchen Tables, Kitchen table Sets, Bistro Table, Bistro Table Sets, Dining Room Table Sets, Dinette, Dinette Set
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Anybody familiar with SB Acoustics
I came across this 10" driver http://sbacoustics.com/specproduct.p...%20SB29NRX75-6
This is a Danish design company that manufactures in Indonesia which lowers the prices a bit!
Madisound (a US retailer) states that in a 2ft^3 box (56.6L) it will give an F3 of 28 hz with ~ a 7.5 cm x 30.5 cm vent. I took it to 65L tuned to 28 hz and got an F3 of <26 hz. Seems pretty impressive for a $150.00 driver!
I'm starting to plan for my first 3-way system, my only other design is a 2-way with a Hiquphon tweeter and a ScanSpeak midwoofer, so I appreciate Danish design and products. However, given the exchange rate, $ to Euro, making an all Danish made 3-way would be very expensive.
So I have several questions:
Does anybody have any experience with this driver?
Would this configuration be appropriate for a woofer in a 3-way (as opposed to a sub)?
How high would you expect to crossover to a mid?
Any comments will be appreciated,
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How to Watch Anaheim California NYE 2016 Fireworks Online Streaming information have been provided here. Anaheim is a city located in Orange County, part of the Los Angeles metropolitan area. In the 2010 United States Census, the city of Anaheim had a population of 336,265, making it the most populated city in Orange County, the 10th most-populated city in California, and the 54th-most populated city in the United States. Anaheim is the second largest city in Orange County in terms of land area (after Irvine), and is known for its theme parks, sports teams and convention center.
The New Year's Eve Dinner & Dance at Orange County Mining Co. is an unusual and exciting way to ring in the New Year. With spectacular views of Orange County and a saloon that brings you back to the mining era, you can enjoy a delicious dinner and dancing for this special evening.
How to Watch Anaheim California NYE 2016 Fireworks Online Streaming?
Anaheim guide to New Years Eve 2016 parties and events! clubZone ranks the top New Years Eve parties in Anaheim based on how tickets are selling so you won't miss out on the most popular events. Check out all the Anaheim New Years Eve parties, get tickets now and make New Years Eve 2016 the best party of the year!
2016 is almost here and it's time to plan your New Year's Eve celebration. From Main Street to Buena Vista Street, the Disneyland Resort is always a great choice to ring in the new year. With so much to offer, the parks will be a popular choice for Southern Californians looking for a festive way to welcome 2016 — but don't worry! We've made a handy guide with everything you need to know to make the most of your special celebration!
We hope that the information on how to watch {Live} Anaheim California NYE 2016 Fireworks Online Streaming will be useful to all.