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Look out if you love to SUP in Costa Rica, you never know when you will find yourself in a machete fight.

http://www.rightthisminute.com/video...088#f3d77c47f8
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Thread: Funniest Video Ever!!!
Feb 19, 2012, 02:12 PM #1Senior Member
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Machete Fight in CR
Last edited by mgarbutt; Feb 19, 2012 at 04:53 PM.
Feb 19, 2012, 03:21 PM #2
1. What a waste of a good machete, which are surprisingly hard to find around here. No respect for a good tool.
2. That "local" looks messed up... maybe drunk or something... loosing his grip and almost falling out of his boat.
3. It's not funny at all.


text:
- Libreria
- >
- Libri in lingua
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- Sexual behaviour
Gay, Straight, and the Reason Why
Un libro in lingua di Simon Levay edito da Oxford Univ Pr on Demand, 2010
- € 29,30
- Il prezzo è variabile in funzione del cambio della valuta d'origine
"This book is the best available summary of the science of sexual orientation. I was struck reading it how much has happened in the field since LeVay's last book, Queer Science. It will be useful both to a general reader---Simon is such a clear explainer---and to a specialist."---J. Michael Bailey, Northwestern University
"LeVay offers a lucid, authoritative account of the exploding literature on the biology of human sexual orientation. Gathering information from a dizzying variety of studies, encompassing genes, hormones, psychology, and the neurosciences, LeVay brings into sharp focus the overwhelming evidence that nature has a say in whom we love."--- S. Marc Breed Love, Michigan State University
"The question of how people become gay or straight is fraught with controversy, yet Simon LeVay has the remarkable ability to tackle this subject in a lively, engaging, and balanced way. He carefully reviews the literature about sexuality and sexual orientation and presents his views crisply, thoughtfully, and always with a touch of humor. There are no axes to grind or political agendas at work here: LeVay dispassionately offers a model of" sexual orientation that brings together key research findings. This hook is compelling, enjoyable reading and a must for anyone interested in the biological hases of sexual orientation,"--- Bradley Cooke, Neurosciencc Institute, Georgia State University
"Simon LeVay provides us with yet additional evidence of both his mastery of the research literature on sexual orientation and his skill at writing about science so that non-scientists can appreciate it. This book should be mandatory reading for everyone needing to understand the evidence for the biological basis of sexual orientation---legislators, members of the clergy, journalists, pundits, and parents."---Dennis Mcfadden, University of Texas at Austin
"Few scholars are as intellectually well-positioned as Simon LeVay to synthesize the proliferation of scientific research on sexual orientation that has blossomed since the publication of his pioneering brain study twenty years ago. This book is rigorous, insightful, and balanced. It provides a welcome antidote to the uninformed debate on this topic, which seems all too rife."---Paul L. Vasly, University of Lethbridge
What causes a child to grow up gay or straight? In this book, neuroscientist Simon LeVay summarizes a wealth of scientific evidence that points to one inescapable conclusion: Sexual orientation results primarily from an interaction between genes, sex hormones, and the cells of the developing body and brain.
LeVay helped create this field in 1991 with a much-publicized study in Science, where he reported on a difference in brain structure between gay and straight men. Since then, an entire scientific discipline has sprung up around the quest for a biological explanation of sexual orientation. In this book, LeVay provides a clear explanation of where the science stands today, taking the reader on a whirlwind tour of laboratories that specialize in genetics, endocrinology, neuroscience, cognitive psychology, evolutionary psychology, and family demographics. He describes, for instance, how researchers have manipulated the sex hormone levels of animals during development, causing them to mate preferentially with animals of their own gender. LeVay also reports on the prevalence of homosexuality among wild animals, ranging from Graylag geese to the Bonobo chimpanzee.
Although many details remain unresolved, the general conclusion is quite clear: A person's sexual orientation arises in large part from biological processes that are already underway before birth. LeVay also makes it clear that these lines of research have a lot of potential because, far from seeking to discover "what went wrong" in the lives of gay people, attempting to develop "cures" for homosexuality, or returning to traditional explanations that center on parent-child relationships, various forms of "training," or early sexual experiences, our modern scientists are increasingly seeing sexual variety as something to be valued, celebrated, and welcomed into society.
Informazioni bibliografiche
- Titolo del Libro in lingua: Gay, Straight, and the Reason Why
- Sottotitolo: The Science of Sexual Orientation
- Autore : Simon Levay
- Editore: Oxford Univ Pr on Demand
- Collana: Oxford Univ Pr on Demand (Hardcover)
- Data di Pubblicazione: 29 Settembre '10
- Genere: Psychology Human sexuality
- Argomenti : Sexual orientation Sex (Psychology Sex (Biology
- Pagine: 412

subset: commoncrawl


text:
Left ventricular hypertrophy is one of the main risk factors for cardiovascular mortality and morbidity. It has been proposed that hypertrophic stimuli act in great part by increasing the size of cardiomyocytes, and that the latter characteristic is a necessary condition to differentiate left ventricular hypertrophy from other benign forms of cardiac enlargement. To test whether the same genetic loci control the size of cardiomyocytes and left ventricular mass, we performed whole genome linkage analyses in a panel of 24 recombinant inbred AXB/BXA mouse strains. Whereas one major locus was linked to left ventricular mass in both males and females, loci linked to the size of cardiomyocytes were clearly distinct and showed sex-specific linkage. Moreover, the parental origin of chromosome Y had strong effects on the size of cardiomyocytes in male mice but did not affect left ventricular mass. In addition to showing that genetic loci that increase the size of cardiomyocytes are not necessarily linked to increased left ventricular mass, our findings have important consequences in evaluating cardiac phenotypes when performing genetic manipulations in mice, and in determining the cause of sex-specific differences when using models derived from C57BL/6J mice.
- cardiac hypertrophy
- cardiovascular genomics
- linkage analysis
- quantitative trait locus
numerous clinical studies have repeatedly and convincingly shown that increased left ventricular (LV) mass (LVM) is highly predictive of cardiovascular morbidity and mortality (4, 10, 15, 30, 41). Inappropriately high LVM is known as left ventricular hypertrophy (LVH). However, it is difficult to set a threshold that differentiates benign cardiac enlargement from maladaptive LVH, because cardiovascular risk increases continuously and proportionally with LVM over a wide range of LVM values, even those extending below what had often been considered as the "upper normal" limit (10, 41). Another difficulty relates to the fact that changes in LVM may result from differences in the number (hyperplasia) or size (hypertrophy) of cardiomyocytes (CMs), in the number of non-CM cells (primarily fibroblasts), and/or in the composition of the extracellular matrix (17). Consequently, there is no simple definition of what LVH corresponds to at the cellular level. The fact that most signaling pathways that lead to LVH have been identified on the basis of their effect on the size of neonatal rat cultured CMs suggests that increased size of CMs is an important feature of LVH (23). Consequently, it has been proposed that any phenotypic characterization of LVH should test whether CMs are enlarged, and that increased size of CMs is one essential feature that distinguishes LVH from other benign forms of cardiac enlargement (17, 21). A natural extension of this postulate is that genes and/or pathways leading to LVH are the same as those that affect CM size. This has led in part to the common practice of measuring CM size to determine whether increased LVM in genetically modified mice truly corresponds to LVH (17).
Genetic crosses between normotensive rodents (to date, mostly rats) have made it possible to identify loci and/or genes linked to LVM independently of blood pressure (5, 13, 25, 31, 42, 46). However, the extent to which genes controlling LVM overlap with those controlling the size of CMs in such crosses has never been verified systematically. This is difficult to test in genetic inter- or backcrosses, because precise measurement of the size of CMs requires their isolation from adult hearts (20) and this procedure is not compatible with measurements of LVM. An alternative tool for linkage studies is that provided by panels of recombinant inbred (RI) strains, where each strain contains a particular combination of genes from the two parental strains consolidated by inbreeding (11). This makes it possible to perform multiple phenotyping, since all individuals within a particular strain share the same genotype. For instance, the panel of AXB/BXA RI strains has been constructed from reciprocal crosses between A/J and C57BL/6J mice (34). Although both strains are normotensive, it has been reported that LV from C57BL/6J mice harbor an eccentric hypertrophy compared with A/J counterparts (24). We therefore used this panel to perform linkage analyses and compare the genetic pathways that control LVM and the size of CMs.
Experimental animals.
All procedures on animals were approved by the Institut de Recherches Cliniques de Montréal (IRCM) Institutional Animal Care Committee and conducted according to guidelines issued by the Canadian Council on Animal Care. Breeding trios for the parental A/J and C57BL/6J strains, the chromosome-substitution (consomic) A/J-chrYC57BL/6J/NaJ and C57BL/6J-chrYA/J/NaJ strains, and the RI AXB/PgnJ and BXA/PgnJ strains were obtained from the Jackson Laboratory (Bar Harbor, ME). For simplicity, all RI strains and consomics are identified without the PgnJ or NaJ suffix, respectively. Because females from some RI strains (BXA1, BXA2, BXA12, and BXA26) are known to be poor mothers, they were substituted with ovariectomized C3SnSmn.CB17-Prkdcscid/J females implanted with ovaries from the corresponding RI strains by the Jackson Laboratory technical services and mated to males from the cognate RI strain. All animals were then bred in the IRCM pathogen-free animal facility. To test for parent-of-origin effects, reciprocal F1 progenies were generated by mating either A/J males with C57BL/6J females (B6AF1) or C57BL/6J males with A/J females (AB6F1). According to a published note from the Jackson Laboratory (2), some nominally independent AXB/BXA RI strains are near-duplicates. Thus we chose only one sister strain per duplicate group: AXB13 [related to AXB14 (now called AXB13a)] and AXB18 [now called AXB19a, related to AXB19 and AXB20 (now called AXB19b)]. A total of 13 AXB (AXB1, 2, 4, 5, 6, 8, 10, 12, 13, 15, 18, 23, and 24) and 11 BXA (BXA1, 2, 4, 11, 12, 13, 14, 16, 17, 24, and 25) were used in the present study. The BXA26 strain was discarded because of breeding problems. All animals were used at 12 wk of age for phenotyping procedures.
Tissue collection.
Tissues were collected from 7–11 male and female individuals for each strain (parental, consomic, or RI) or F1 cross. On the day of tissue collection, each mouse was weighed for determination of whole body weight (BW) and killed by cervical dislocation, and several tissues (heart, thymus, adrenal glands, and kidneys) were collected. Heart ventricles were dissected into right ventricle (RV, without the septal wall) and LV (including the septal wall). Each tissue was blotted dry and weighed individually. Relative tissue weights were then calculated for LV (LVW/BW), RV (RVW/BW), thymus (TW/BW), both adrenal glands (AW/BW), and both kidneys (KW/BW).
Cardiomyocyte isolation and videomicroscopy.
CMs were isolated from four or five male and female individuals for each strain (parental, consomic, or RI) or F1 cross. After anesthesia was induced the heart was quickly removed from each mouse and mounted for cardiac retrograde aortic perfusion, and CMs were isolated as described previously (47). After the last Ca2+ restoration, cells were fixed for 10 min in 80 mM phosphate buffer containing 1.5% glutaraldehyde, a solution shown to preserve all dimensions of isolated CMs (22). After fixed cells were pelleted by gravity for ∼10 min, they were resuspended in 100 mM phosphate buffer and examined with an Axiovert S100TV microscope (Zeiss) with slight modifications of our previously published procedure (14). In short, the profiles of cells were visualized by autofluorescence (excitation 540 nm, emission 620 nm), and their image was captured with a Retiga EXi monochrome camera (Qimaging, Surrey, BC, Canada). The area, length, width, and width-to-length ratio of ∼100 CMs per heart were measured with the public domain Java image processing program ImageJ (40).
Blood pressure measurements.
To measure diastolic blood pressure (DBP), systolic blood pressure (SBP), mean arterial pressure (MAP), pulse pressure (PP) and heart rate (HR) in conscious unrestrained mice, three male and female individuals from each strain (parental or RI) or F1 cross were implanted under isoflurane anesthesia with telemetry devices (Data Sciences International, St. Paul, MN). The catheter of the implant was inserted into the aortic branch through the left carotid and maintained by two ligatures, and the body of the transmitter was inserted into a subcutaneous pocket at the right inguinal level. Animals were allowed 1 wk to recover from surgery, and all measured values were then recorded for 48 h. Males from the BXA14 and BXA24 strains were discarded because of consistent postimplantation behavioral problems.
QTL mapping.
Genotype data [either single nucleotide polymorphisms (SNPs) or simple sequence length polymorphisms (SSLPs)] were obtained from GeneNetwork (www.genenetwork.org) and edited to remove unused strains and loci with identical strain distribution patterns. Undefined genotypes in sister strains were edited with original data from the Wellcome Trust Center for Human Genetics (www.well.ox.ac.uk/mouse) and the Mouse Genome Informatics (www.informatics.jax.org). A total of 965 autosomal and 29 X-specific polymorphic markers were used. None of the quantitative trait values was transformed, because they all conformed to the normal distribution according to the D'Agostino test for normality. Genomewide scans were performed separately in males (with only autosomal markers) and females (with both autosomal and X-linked markers).
Analyses were done in three stages as previously described (43), using the R/qtl package (6). First, main quantitative trait locus (QTL) effects were detected by performing single-QTL genome scans. Significance thresholds were set at the P < 0.63 (suggestive) and P < 0.05 (significant) levels as suggested previously (28, 33). Thresholds were calculated on the basis of permutation tests (1,000 permutations) performed on the data sets themselves (16). Confidence intervals (CIs) were determined by calculating the 1.5-log of odds ratio (LOD) support interval, as recommended recently (32). On the basis of the values of CM size obtained in reciprocal F1 and consomic animals (Fig. 1), the genome scans for CM size components were performed in males by defining the parental origin of chromosome Y (chr Y) as a covariate in either additive or interactive models. The interactive model was used when it yielded significant QTLs whose LOD score differed from the scores calculated by the additive model by a value >2.0 (27). The second step consisted of performing a two-QTL, two-dimensional genome scan for all traits to detect potential epistatic interactions. Because single-QTL analysis is based on its marginal effect and does not take into account other loci, the third step used a multiple regression model to reevaluate the statistical linkage of each locus to the phenotype of interest in the context of all other loci (identified as either QTLs or suggestive loci by the single-locus scans). With this analysis, terms that fail to meet significance thresholds under the new criteria are eliminated one at a time, and the analysis is repeated until all remaining loci are significant. This method also calculates the contribution of each significant locus to the total variance, based on adjusted (type III) sums of squares, and the percentage of the total variance is accounted for by all combined loci.
Differences between groups were evaluated by t-tests or one-way ANOVA followed by Keuls post hoc analysis. Correlations between phenotypes were evaluated by calculating r2 values on the basis of linear regression. All calculations were performed with GraphPad Prism (GraphPad Software, San Diego, CA).
Phenotypic analyses.
In parental strains, LVW/BW (but not BW or RVW/BW) was higher in C57BL/6J mice than in A/J counterparts; likewise, the surface area of CMs from C57BL/6J was greater than that of A/J counterparts (Table 1). Both strains were normonsive, with MAP and SBP being slightly more elevated (by ∼10 mmHg) in male (but not female) C57BL/6J mice. Phenotypic values for other traits are compiled in the supplemental data for this article (Tables S1 and S2).1
Analysis of the reciprocal AB6F1 and B6AF1 crosses revealed a strong parent-of-origin effect on the size of CMs in males, but not in females (Table 1 and Fig. 1A). To test the potential contribution of chr Y from each strain, we used reciprocal consomic strains C57BL/6J-chrYA/J [C57BL/6J mice carrying the nonpseudoautosomal region (NPAR) of chr Y from A/J] and A/J-chrYC57BL/6J (A/J mice carrying the NPAR of chr Y from C57BL/6J) and tested whether substituting the NPAR of chr Y between the C57BL/6J and A/J strains affected the size of CMs. We found that the presence of chr Y from C57BL/6J into pure (C57BL/6J or A/J) or mixed (F1) genetic backgrounds was associated with increased size of CMs compared with counterpart strains carrying chr Y from A/J (Fig. 1A). In contrast to CM size, LVW/BW did not differ between consomic strains and their corresponding host strain (data not shown), or between reciprocal F1 animals (Table 1).
Distributions of the trait values among all 24 RI strains are shown in the supplemental data for this article (Tables S1 and S2). All strains were normotensive, but there was a significant correlation of the LVW/BW values with those of telemetric MAP; however, the values of the correlation coefficients (r2 = 0.23, P < 0.05 in males; r2 = 0.27, P < 0.01 in females) indicated that MAP was not responsible for >23–27% of the variance of the LVW/BW values (Fig. 1B). In contrast, there was no correlation between CM size and MAP. Of note, CM surface area is a very robust and precise phenotype. Accordingly, the intrastrain coefficient of variability of CM surface area averaged ∼3% in either males or females, whereas CM surface area in strains with the largest CMs was up to 42% higher than in strains with the smallest CMs. Moreover, despite the fact that LVW/BW and CM size were both greater in C57BL/6J than in A/J, the two traits segregated independently when examined in all 24 RI strains (Fig. 1B).
QTL mapping.
After the single-locus scan, we detected significant QTLs for LVW/BW and CM size components (Fig. 2, Table 2), but not for any of the other phenotypes measured, including blood pressure values and normalized weight of other tissues (data not shown). For LVW/BW, we detected one major QTL (named QTL Lvm1 for left ventricular mass QTL 1) showing linkage in both sexes (Figs. 2 and 3). Interestingly, the A/J allele at the closest marker to Lvm1 was linked to the highest phenotypic value, despite the fact that the A/J parental strain had a lower LVW/BW than C57BL/6J. QTLs linked to CM size components were different in males and females and clearly distinct from Lvm1 (Fig. 2). In females, one major QTL on chr 14 (named Cms1 for cardiac myocyte size QTL 1) was linked to both CM area and length (Figs. 2 and 3). A peak showing the same profile at the same position also showed suggestive linkage to CM width. This suggested that both length and width contributed to the variance of CM area, as confirmed by the multiple regression model (see below). In females, another QTL on chr 5 (named Cms2) showed significant linkage to CM width only. In males, given that the origin of chr Y had a strong effect on CMs from either reciprocal F1 or consomic strains (Fig. 1A), genome scans for CM size components were performed by defining the parental origin of chr Y as a covariate. With the additive model, one major QTL (named Cms3) showed significant linkage to both CM area and width (Fig. 2). Although found on chr 5, the profile and location of Cms3 in males was clearly distinct from that of Cms2 in females (Fig. 3).
The two-QTL, two-dimensional genome scan did not detect any epistatic interaction between the autosomal QTLs in both males and females. However, to test possible interactions of QTLs with chr Y in males, we repeated the single-locus scan by setting the origin of chr Y as an interactive covariate. This analysis revealed two additional QTLs that were not detected in the previous analysis: Cms4 on chr 10 (linked to CM area and width) and Cms5 (linked to CM length) (Fig. 4). All the above QTLs (along with their positions, LOD score, and phenotypic effects) are summarized in Table 2.
To reevaluate the importance of chr Y and the single-scan QTLs in the context of all other loci (either significant or suggestive), build the final linkage model, and calculate which percentage of the total variance is accounted for by all loci, all data were recalculated with the multiple regression model. The results (Table 3) show that 1) both in males and females, Lvm1 contributed to a large part of the variance (∼31%) of LVW/BW; 2) in females, Cms1 and Cms2 each contributed to a large part of the variance of CM size components; 3) some loci other than QTLs identified by single-locus scans contributed to part of the variance of LVW/BW (both in male and females) and CM size components (in females); 4) in males, chr Y (as well as its interactions with Cms4 and Cms5) contributed to a large part of the variance of CM size components (ranging from 15% to 32%); and 5) other QTLs contributing individually to CM size components in males were Cms1, Cms2, and Cms3.
The present study allowed us to identify for the first time natural genetic variants that control CM size in mice. Most of these loci were sex specific and, importantly, were different and distinct from the major QTL Lvm1 that controlled LVM in both sexes. The distinct influence of loci controlling LVM and CM size was reinforced when examining the effects of the origin of alleles on the phenotypes. Indeed, strains with AA genotypes for Lvm1 had greater LVM than their BB counterparts, whereas the CM strains with BB genotypes at all Cms loci had increased size compared with their AA counterparts. Interestingly, regulation of the width and the length of CMs has been suggested to correspond to different biological processes controlled by different regulation pathways, with increased width corresponding to the addition of sarcomeres in parallel, while increased length corresponds to the addition of sarcomeres in series (3, 38). This notion is compatible with our findings showing that (in addition to the effects of chr Y) 1) in females Cms1 was linked to both area and length of CMs, whereas Cms2 was linked only to CM width, and 2) in males Cms 3 and Cms4 were linked to both area and width of CMs, whereas Cms5 was linked only to CM length. Others had suggested that beyond absolute values, the width-to-length ratio of CMs was a very conserved and tightly regulated phenotype (20). However, in contrast to absolute values of CM size, we did not detect in the present study any QTL linked to this relative ratio.
None of the QTLs identified in the present study showed any obvious overlap with QTLs previously reported (either by us or by others) as being linked to LVM, either in mice or in syntenic regions in other species, nor did we identify within these QTLs any obvious candidate genes on the basis of their known function. However, the latter strategy suffers from limitations, as it has been shown that it may distract from identification of genes that are truly linked to a trait but could not have been suspected on the basis of their known functions (39). Identification of culprit genes will therefore need to wait until congenic lines further narrow the regions of interest.
Of note, others had previously used the same panel of AXB/BXA RI mice to acquire cardiac phenotypes by M-mode echocardiography and estimate LVM, but these authors did not report on association of a QTL with LVM (36). However, we have verified that there was no correlation between the values of LVW/BW acquired by ourselves with the values of LVM estimated on the basis of noninvasive echocardiography. We postulate that, despite its utility in evaluating LV function and morphology in the very contrasted parental strains, this method does not have sufficient resolution to detect smaller differences in LVM in the RI strains that constitute this panel. In contrast to LVW/BW, the values we obtained for telemetric blood pressure were very similar to those published by others using the same method and the same parental C57BL/6J and A/J strains (35). However, we did not detect any QTL linked to any component of blood pressure, and the latter cannot therefore account for any of the phenotypic differences in LVW/BW or CM size.
It is well established that there are important differences between males and females in cardiac morphology, function, and disease progression, both in humans and in animal models (9, 12, 18, 29). From a genetic standpoint, sex-specific differences in linkage from various studies do not manifest themselves in the same fashion for all loci. For instance, in a previous study with rats, QTLs linked to LVM in males were different from those linked to the same phenotype in females (31). This is in contrast to the present study, where there was a perfect match of the linkage profile of Lvm1 in both male and female mice. From a phenotypic standpoint, sex-specific differences concern many aspects of cardiac physiology and are more the rule than the exception (9, 12, 18, 29). Although these differences may arise from multiple mechanisms (including differential effects of sex steroids), there has been evidence that chr Y carries genes that may affect cardiovascular outcome (8). Accordingly, chr Y variants have been linked to blood pressure in rats (19) and humans (44), as well as to cholesterol levels in the human population (7). However, the mechanism by which chr Y associated to these phenotypes has always been elusive and has never been linked to a phenotype to the level of a well-defined cell type. In our study, we found that chr Y accounted for a large part of the variance of CM size, both in the background of parental strains and in the mixed background of RI strains. The interactions of the responsible genes on chr Y with that of other QTLs (and how the latter differ from those linked to LVM) are summarized in part in Fig. 5. Outside of their effect on sex determination and germ cell function, the function of genes on chr Y are still poorly understood (26). It has been reported that chr Y from most mouse laboratory strains (including A/J and C57BL/6J) all originated from common male Mus musculus molossinus ancestors (37). However, it was reported recently that chr Y polymorphisms in A/J and C57BL/6J mice are capable of modifying autoimmune disease susceptibility (45), indicating that some genetic drift in chr Y must have occurred. Accordingly, recent data indicate that ∼10% of all 4,935 identified SNPs on chr Y are polymorphic between A/J and C57BL/6J (1). Further experiments on the mechanisms responsible for the effect of chr Y on CM size might provide an important adjunct for understanding how genes on chr Y affect cardiovascular outcome.
Importantly, there is an ever-growing list of examples where the effects of gene manipulations in mice (resulting from knockout, overexpression, or dual targeting) on cardiomyopathy phenotypes differ between male and females (18). These differences concern survival, the level of hypertrophy and/or fibrosis, as well as dysfunction (18). The mechanisms responsible for these sex-specific differences have often not been resolved, but C57BL/6J mice are the preferred genetic background for most genetic manipulations. We do not know yet whether chr Y (beyond its effect on CM size) also affects cardiac function, particularly in the context of disease and perturbed genetic regulation. However, our data suggest that, at the very least, sex-specific differences in the C57BL/6J background should not be generalized to all mouse strains.
In summary, our data show that genetic loci that increase the size of CMs do not necessarily lead to increased LVM, and that different loci can even influence both phenotypes independently from each other. Consequently, one cannot assume that genetic modifications in animals should automatically alter both phenotypes to the same extent. We also found that chr Y from C57BL/6J harbors allelic variants that have strong effects on the size of CMs. Since C57BL/6J mice are the preferred background for most genetic manipulations, the origin of chr Y should be assessed when genetic manipulations affect phenotypes in a sex-specific fashion in models derived from C57BL/6J mice.
This work has been supported by National Heart, Lung, and Blood Institute Grant HL-69122 and by Canadian Institutes for Health Research Grant MOP-64391.
↵1 The online version of this article contains supplemental material.
Address for reprint requests and other correspondence: C. F. Deschepper, Experimental Cardiovascular Biology Research Unit, Institut de Recherches Cliniques de Montréal (IRCM), 110 Pine Ave West, Montréal, QC, Canada H2W 1R7 (e-mail: christian.deschepper{at}ircm.qc.ca).
Article published online before print. See web site for date of publication (http://physiolgenomics.physiology.org).
- Copyright © 2007 the American Physiological Society


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saturDAY'S HIGHLIGHTS
Pirates 7, Cardinals 1: A.J. Burnett scattered four hits over seven innings, Russell Martin hit a three-run homer, and Pittsburgh beat St. Louis to regain sole possession of the N.L. Central lead.
Red Sox 7, White Sox 2: Jake Peavy pitched seven strong innings against his former team, and Boston beat Chicago for its sixth win in seven games.
Dodgers 2, Padres 1: Pinch hitter Mark Ellis singled home the go-ahead run in the eighth, and Los Angeles rallied to beat San Diego. Just as the game ended, the Dodgers announced they had acquired third baseman Michael Young from the Phillies for minor league lefty Rob Rasmussen.
Rangers 2, Twins 1: Leonys Martin hit a game-winning bases-loaded single with two out in the ninth inning to give Texas a victory over Minnesota.


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A SkyWest commuter jet heading to Los Angeles from San Diego International Airport was delayed for almost two hours Tuesday after a parolee who breached security boarded the plane.
The man forced his way through a security door near the baggage claim area of the commuter terminal about 11 a.m. and walked onto the tarmac, airport spokesman Steve Shultz said.
The door triggered an alarm and the Harbor Police officer who responded found passengers boarding the plane on the tarmac, said Port of San Diego spokeswoman Marguerite Elicone.
Officers notified the flight crew of the possible breach while flight attendants were conducting the final count. They noticed that there were 28 passengers on board — one more than the ticketed number — and the trespasser walked off the plane and was arrested by waiting officers, Elicone said. He was not armed.
The whole incident lasted five to six minutes, she said.
Marc Rory Duncan, 38, was booked into jail on two misdemeanor charges of entering an airport without authority and avoiding the screening process, and on a felony parole violation. He had just been released from prison a day earlier after serving time for violating probation on a theft conviction, according to officials and court records. He also has a previous auto theft conviction.
He is scheduled to be arraigned Thursday.
It was unknown why he boarded the plane.
After the incident, all of the plane's passengers were escorted off the jet and sent back inside the terminal where they were rescreened.
All of the luggage aboard the plane was taken off and rechecked using bomb-sniffing dogs, Shultz said.
The flight, No. 6323, which was scheduled to depart at 11:10 a.m., took off at 1:05 p.m., he said.
The incident will be investigated by police, the Transportation Security Administration and airport officials.
"Once the alarm went off, everything went the way it was supposed to," Elicone said.Copyright © 2017, The San Diego Union-Tribune


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A team of future health visitors, sponsored to train in Lincolnshire, will start studying for their qualification this month.
The intake will be the latest supported by Lincolnshire Community Health Services NHS Trust (LCHS) as part of a national recruitment drive to increase the number of health visitors available to support families.
Health visitors provide care, advice and support to families from pre-birth and at regular intervals until the child starts school. They can help parents on issues including child development, breastfeeding, introducing solid foods, immunisations and behaviour.
Since 2012, LCHS has pledged to sponsor 45 places on honours degree courses at universities in Sheffield and Leicester to train new health visitors.
The students, already qualified nurses, will complete the year-long public health course to qualify as a health visitor. The courses allow students to divide their time between academic study and hands-on clinical practice, supported by an experienced mentor.
The January cohort will account for the final 10 places out of the 45, while 15 health visitors from previous cohorts have already qualified and started working.
Anita Wood, Health Visiting Strategic Lead for LCHS, said: "Health visitors can help families give children the best possible start in life. By having a greater number, we hope to make an even bigger difference as these children develop and grow.
"Over the past 18 months, we have been working to ensure we have a strong calibre of students to sponsor through the course, most of whom are now working full-time with the service.
"In addition, we have been using the opportunity to develop the services we offer and have undertaken a number of successful pilots, including developing our antenatal contacts with families coming into the health visiting service; text reminders for parents with children attending two-year reviews, and extra training for health visitors on supporting maternal mental health."
Laura Horton has completed her health visiting training in the Boston area. She said: "This last year has been an immense learning curve for me. The Boston Health Visiting Team have all been supportive and I feel that being a health visiting student has been a very positive experience. I have been lucky to gain a wide array of experiences that many other student health visitors do not get the opportunity to experience."


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With no doubts, Double Strollers are the most essential and best parenting gear. There is no one perfect stroller. If there was, every family with twins would own it. Different families have different needs; some stroller models meet particular needs better than others. The Double stroller will take you from the infant stage through to the time when your babies really enjoy walking good distances on his/her own, about his/her third year.
There are few advantages and disadvantages on both styles of Double Strollers, and all the parents have a strong preference for one or the other model of Double Strollers. Try out models in both styles to evaluate which you feel most comfortable with. Some families realize the need for both styles. Talk to other parents about their experience with different models of the Strollers; your local multiples club is a great resource for this kind of information.
MyStrollers.com has only one motive: making the world of Parenting easier, more enjoyable and affordable.. We have best strollers from all major Brands like
Baby Jogger, Bob Strollers, Mountain Buggy, Phil And Teds, Zooper,
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Strollers and many more. Whether you are looking for a single stroller or a double stroller, we have it all! All Best Stroller products that are listed are of highest quality of any strollers in the market. We are committed to helping you find the Strollers that best meet your needs.
Many families put as much thought into choosing a stroller as they do into selecting the make and model of a new car! And for good reason. When you have multiples, a stroller is a crucial piece of equipment. Your mobility depends on it. Without one -- or with the wrong one -- moving babies from place to place can be a logistics nightmare. The right equipment makes for happy babies and happy parents.


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Jaguar revealed one of the angriest models in its history, the 567hp F-Type SVR at the Geneva Motor Show.
Jaguar's halo F-Type will be available both in coupe and convertible versions, offering 567hp (575PS) and 516lb ft (700Nm) of torque from its supercharged 5.0-litre V8 engine.
The SVR department of JLR managed not only to make the F-Type more powerful, but also slightly lighter, partly thanks to a new lightweight exhaust system made out of titanium and Inconel.
All in all, the new Jaguar F-Type SVR is 25kg lighter than an AWD F-Type R, with the figure showing 50 kg less when optioned with the carbon ceramic brakes and a carbon fiber roof.
The slightly modified eight-speed auto gearbox now shifts even faster, allowing the all-wheel drive F-Type SVR to accelerate to 60mph in just 3.5 seconds and onto a top speed of 200mph (320km/h) for the coupe and 195mph (313km/h) for the convertible.
SVR also fettled with the all-wheel drive system, in particular with the rear electronic active differential to better distribute the torque and work in conjunction with the DSC system.
The new aero agenda of the F-Type SVR might not gain positive views by fans of the original model, but Jaguar says that everything, from the redesigned front bumper to the rear wing and diffuser is there to smooth airflow and generate more downforce.
What do you think?
Photos: Brad Anderson/CarScoops


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Tired of the controversy surrounding the use of Native Americans as their mascot, major stockholders in the company that owns the Braves have voted to change the mascot to a dung beetle.
"No one can tell us it bothers their ancestors, and we won't be keeping no mammals in no cages no more, like some of them college teams do, " said Earl P. Hydnik, spokesperson for the company.
Marilyn Sweeney, a PR specialist, was hired by Hydnik to do an ad campaign introducing the new mascot, logo, and a new trademark rallying cry to replace the infamous "chop and holler."
"We're very excited to be chosen for this honor," she said. "The Braves were great for their time, but that time has passed. Now it's time for a new persona that reflects our concern for the rights of human cultures and animal rights, yet maintains a sense of fierce pride and determination to win. The dung beetle does it all. As far as animal rights, beetles are just as well off in captivity as in the wild, probably more so. All we have to supply are a large portable aquarium filled with dirt, a few flies, ants, and the occasional grub, and a little poopy from the manager's dog. And determination? You've never seen anything so small push something so huge and smelly in your life. What better metaphor for the game of baseball than pushing around a giant ball of crap; i.e., your opponent? Huh? Clever, eh?"
Athletic sportswear and equipment companies have already begun churning out t-shirts, caps, stadium seats, jackets, and the like for the 2006 season. One fan, a youngster of eight, was interviewed at the last Braves game.
"Awesome," said Dustin Green of Villa Rica, GA. "It's great. Nobody else has the colors black and brown. Also, I won't get in trouble for saying "poop" and "crap" now, since my parents are big fans. I want the new t-shirt that says, 'We're not taking any of your sh**,' and has this beetle with huge muscles rolling this ball of crap into a giant toilet. Dung beetles rock!"
A few older fans objected on the grounds they would be ridiculed. Ms. Sweeney addressed this concern at a public forum in Atlanta Underground Friday night.
"It's one of those things you have to get into to understand and appreciate it, sort of like mud wrestling. I did that to put myself through college. Some people think it's disgusting and degrading, but unless you're doing it you can't judge. All us girls were like sisters and we had a blast.
"Same here. When people see the Atlanta Dung Beetles take the other teams down, they'll be the ones being ridiculed. Other teams will be sorry they've stuck by their tired, worn-out, 19th century era mascots when the Dung Beetles make it big. We've even signed a major fashion model to advertise in the Sports Illustrated swimsuit issue with a very wet Dung Beetle t-shirt and nothing else."
The new rallying cry is a sound produced by licking the heels of one's hands, pressing them on the lips, and blowing. A similar sound can also be produced by inserting a plastic straw into a sweaty armpit and blowing.
Longtime Atlanta baseball fan Arlo Metrie of Wayne, GA, who was part of a sample fan test group, felt reticent about the new cheer at first.
"i kept thinking I wouldbe sent to detention. But once I relaxed,it was the most natural thing in the world. Brought back memories of nights at Scout camp."
Dung Beetle paraphernalia, including a patented, souped-up version of the plastic straw guaranteed to increase the volume of your cheer by 75%, will be on sale in time for the 2005 holiday season.


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Home-grown terror a new reality: Chidambaram
Home Minister P Chidambram said "we live in the most troubled neighbourhood in the world."
Zeenews Bureau
New Delhi: Union Home Minister P Chidambaram, Thursday, refuted the allegations from the opposition and said that India is dealing with a very complex internal security problem.
Terming home-grown terror modules as the "new reality" faced by India, Chidambaram said the problem was not paid adequate attention when the nation was fighting cross-border terrorism.
He added that in the past, terrorists used to come from across the border, but now home-grown terrorism like SIMI and IM is the new reality.
Replying to a short duration discussion in the Rajya Sabha on the situation "arising out of growing incidents of terrorism in the country with special reference to recent blasts in Mumbai on July 13," Chidambaram said the country was building capacities to improve intelligence gathering and fight terrorism.
He said security forces had neutralised 51 terror modules and added that the National Investigation Agency (NIA) has a very good record of filing chargesheets and was currently probing 29 cases.
Earlier, intervening in the debate, Leader of Opposition Arun Jaitley said there can be no place for compassion in dealing with terror and national security should prevail over vote bank politics.
Arun Jaitley also said that it was unfortunate that the Union Minister had no answers on the security lapse, which unfortunately led to the recent Mumbai blasts.
Chidamabaram said as long as the epicentre of terrorism was in Afghanistan and Pakistan region, "we will continue to be under the terror shadow".
"We live in the most troubled, vulnerable neighbourhood in the world," he said.
He said initially terrorism was imported from across the border.
"The new reality is that this is not the only source of terror anymore. The second fact we must realise is that many terror groups are home-grown terror. They may be inspired by groups outside but they are in India and they are Indian modules."
He said when Indian modules of these groups were being formed, the nation "failed to recognise them".
"How SIMI (Students Islamic Movement of India) has morphed into Indian Mujahideen," he said.
He said that while the investigating agencies were probing jihadi cases, right-wing fascists were also on the rise in India.
"All over the world, right wing fascist groups are on the rise," he said.
Pune and Mumbai blasts are "two major blots": PC
Home Minister P Chidambaram today said there are indications of involvement of Indian module in the July 13 Mumbai blasts that killed 26 people.
It is for the first time that the government has pointed towards the involvement of a homegrown terror group for the three explosions in the metropolis.
"While no conclusion has been reached, all indications point to Indian module," Chidambaram said about the Mumbai blasts, adding that perhaps it could be the same module that carried out a blast in the German Bakery in Pune last year.
He said the Pune and Mumbai blasts are "two major blots" in the last 32 months since he assumed the charge of Home Minister. "I accept it," he said.
Chidambaram said another mistake was to point fingers at a particular religion whenever a bomb blast took place.
Describing the period from 2002 to 2008 as the worst phase of terrorism related violence, Chidambaram said there was a "failure to recognise" the growth of SIMI and Indian Mujahideen in these years at the political and government level.
He said that the security forces have so far smashed 51 terror modules in last two years. "We have successfully busted a number of modules," he said.
Chidambaram said that considerable improvement has been noticed in the intelligence machinery both at the state and at the central level.
He said the Centre was receiving cooperation from chief ministers of all the states including those ruled by the opposition parties.
While the trial process in India was slow, the government in the last few months has invested thousands of crores of rupees into police modernisation and recruitment.
Citing terror attacks in other parts of the world, he said it was a myth that the US was free from any terror attack after 9/11.
The Home Minister said the National Investigative Agency has been a success story while the National Security Guards (NSG) have been empowered and expanded.
The NATGRID (national intelligence network) will be in place in the next 18 months and the entire software for the system will be built by an Indian company.
No foreign company will be involved in this process, Chidambaram said.
He noted that the Prime Minister has said there will be full fledged discussion on the NCTC, which will subsume the NATGRID.
With agencies inputs


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Samsung Opens BD 'Resource Center'
In case you haven't noticed, consumer electronics has gotten complicated. This is obvious to everyone who has read the 200-page owner's manual for their cell phone. Well, actually, no one has ever read their cell phone manual, but you get my point.
One of the newest complicated technologies is Blu-ray. Buying a player is more than just finding a front panel that matches your coffee table. You need to know some techno stuff. And, many Blu-ray players are able to download firmware to fix bugs or add features. The latter can be a source of frustration for owners, especially because it's often hard to find where the code is lurking on the web.
To the rescue, Samsung has opened the Samsung Blu-ray Resource Center. This website is dedicated to all things Blu-ray. It is bifurcated into one section for owners, and one for would-be owners. The latter "looking to buy Blu-ray" section has a nice FAQ with shopping topics like "what's the benefit of 24p" and "What does Profile 1.0, 1.1, 2.0 mean?" This is undeniably useful information for the first-time buyer. Throw in a bit of advertorial for Samsung products, and it's a good place to begin browsing.
The "for Blu-ray owner's" section gets a more in-depth FAQ, and deals more particularly with issues specific to Samsung players. For example, "Does Samsung support its older Blu-ray players once the new models are being sold?" And, most importantly, you can get the latest firmware releases from this page. There's even a bit of a help desk with the topic, "I updated my firmware and I still can't play my new Blu-ray movie. Did I do something wrong?" Finally, the firmware download page has clear instructions for performing the operation, so even newbies can do it.
If you have a Samsung Blu-ray player, check out this site. Whether your player (BD-P1000, BD-P1200, BD-P1400, BD-UP5000) has issues, or it just needs a tune-up, this site might do the trick. Case in point, the v1.3 update for the BD-UP5000 upgrades this player to Profile 1.1, adding HD audio bitstream output.
Excellent. Now, if only I can figure out how to use the camera on my cell phone. -Ken C. Pohlmann


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Written on: 01/09/2005 by waterlily1882 (26 reviews written)
Good Points
Easy and straight forward to use.
Bad Points
Packaging can be a bit of a nightmare to open.
General Comments
I have recently switched to HP Ink cartridges after finding generic brands didn't give me the quality of printing I require. They are easy to install (once you get inside the foil packaging) it's basically a case of slotting the cartridge in, closing the lid and hey presto hassle free printing. Long lasting so not constantly having to replace them.
" Utter Rubbish " Read More
" Recycling " Read More
" it was great i don't know what to say " Read More
" Having been thoroughly disgusted at the price of replacement inkjet... " Read More
Written by NickyNoogle
" Hp C4836A Compatible cartridge is a re-engineered cartridge that me... " Read More
Written by ethrestroh


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Contact: Joyce Masterson, 760-839-4621
Escondido will observe Arbor Day by holding a cleanup and tree planting event on Friday, April 26, 2013. Beginning at approximately 7:30 a.m. ten tree crews from the private sector will join with City public works staff to perform tree maintenance at the California Center for the Arts, Escondido and Grape Day Park. Due to safety concerns, various areas of the park will be closed to the public until approximately 2:00 p.m. while the work is completed. A ceremonial tree planting by the Mayor and local school children also will be held at 2:00 p.m. in Grape Day Park.
The event is being coordinated by the Professional Tree Care Association of San Diego (PTCA) in partnership with the City of Escondido, Grangetto's Farm and Garden Supply, the California Center for the Arts, Escondido and the San Diego Urban Forest Council. Persons interested in volunteering may contact Mike Reed at 760-802-9041.
Every Arbor Day PTCA has volunteers from its membership donate labor and equipment to non-profit organizations to assist them in tree maintenance they might otherwise not be able to afford. This year they will be volunteering in two locations: the California Center for the Arts/Grape Day Park in Escondido, and also Girl Scout Headquarters in San Diego. Over the years, the PTCA has assisted the City of San Diego at numerous park locations, The Boy Scouts, Quail Botanical Gardens, Campfire USA and many others. This will be the 20th year the PTCA has provided free labor and expertise to beautify the urban forest in San Diego.
PTCA estimates the value of the donated labor at approximately $20,000.
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As the nation's premier heart and diabetes research institute, our training programs provide the latest research and knowledge to assist clinicians in the management and prevention of diabetes in the community.
The Baker Heart and Diabetes Institute education programs are endorsed by Australian College of Nursing, Australia (ACN) according to Continuing Professional Development Endorsed Course Standards.
Who should attend Baker Institute training programs?
The Institute delivers a range of programs that are specifically targeted to health professionals assisting people who have type 1 or type 2 diabetes.
This includes:
- Practice Nurses
- General Practitioners
- Community Health Nurses
- Diabetes Nurse Educators
- Allied Health Professionals, including Dietitians and Exercise Physiologists.
The Baker Institute Education Services team
Our multi-disciplinary team of expert Diabetes Specialists, Credentialed Diabetes Nurse Educators and Accredited Practising Dietitians are at the forefront of management, research and education for patients with diabetes. With a wide range of experience, our highly skilled presenters aim to facilitate the practical management of diabetes — and related complications based on the latest research and best practice developed at the Institute and around the world.
Workplace and Community Presentations and Workshops for Clinical and Non-Clinical Professionals
The Baker Institute Education Services team share a commitment to the research, design and delivery of a range of training programs to suit the varied requirements of healthcare workers within Australasia.
While our programs and workshops are targeted to health professionals working directly with people initiating or managing their diabetes care, the Education Services team is available to discuss and plan the delivery of training programs, workplace and community presentations which can be tailor made to the meet the individual needs of your organisation.
2017 Health Professionals Training
Carbohydrate Counting for Managing Diabetes
Suitable for dietitians and diabetes educators, including new graduates, working with people with diabetes.
Overweight and Obesity: the challenges and solutions
Suitable for medical practitioners and allied health professionals working with clients to manage obesity including dietitians, diabetes educators, practice nurses and exercise physiologists.
FlexIT: Flexible Insulin Therapy for Health Professionals
Suitable for diabetes nurse educators and dietitians working with clients managing type 1 diabetes.
2-day program – $500
Further information
Manager, Allied Health and Education Services
E firstname.lastname@example.com
Terms and Conditions
- Early Bird Registration Special: to take advantage of the early bird special rate, registration and full payment must be received by the closing date.
- The Baker Institute reserves the right to cancel, postpone or reschedule courses where registrations are insufficient or due to unforeseen circumstances. Should this occur the registration payment will be refunded.
- Participant cancellations occurring less than 7 days prior to the program will incur a 20 per cent administration charge. Cancellations less than 48 hours prior to the program will forfeit the full payment, however, a substitute delegate is welcome.
- The Baker Institute reserves the right to change program, event or seminar fees, dates, content, speakers or method of presentation at its discretion.
- Where a refund is due to a company or participant, a full refund cheque or electronic transfer will be organised within 30 days of the event, seminar or program.
- Where a course is overbooked, participants who have paid prior to the commencement of the event, seminar or program will be given priority.
- The Baker Institute reserves all rights, title and interest in all intellectual property used by it in performing the seminar services (subject to the rights of the presenters) and all intellectual property we may develop as a result of the performance of the seminar services.
- You agree not to delete or modify the materials or any copyright, trade mark, or other proprietary notices in the publication or transmission of materials from the seminar.
- Participants acknowledge and agree that the Baker Institute is not responsible or liable for any loss arising out of or in connection with any participant's use of or reliance on the training programs, workplace and community presentations or any verbal information given to the Participant during the conduct of such training programs, workplace and community presentations.


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08 Jan 2013
Pamper Your Little Ones in 2013 with a Five Star Kids Friendly Holiday at Anantara
All too often five star holiday retreats only cater for the adults and tend to forget the kids. With this in mind, Anantara has created unforgettable luxury escapes which invite families to discover exciting new adventures with a wide range of child friendly activities.
Activities range from playing traditional local games, making arts and crafts, and enjoying pool playtime and treasure hunts with new friends. In addition, Anantara spoils younger guests with little extras such as welcome and departure gifts, kids' in-room amenities and turn down treats, ensuring that the holiday of a lifetime is even more special from start to end.
In Thailand children's ele-adventure dreams are brought to life at Anantara Golden Triangle Resort & Spa's famous on-site Elephant Camp, with expert "mahout" (elephant carers) teaching kids the Thai commands to drive their very own gentle giant.
Families who journey down the Andaman coast to Anantara Si Kao Resort & Spa receive kids' welcome backpacks, containing a map highlighting the most fun resort facilities, including a children's wading pool and water slide, a playground and mini golf course, as well as beach volleyball and garden play areas. Andaman exploration reveals some of Thailand's best kept secrets. Swim through a cave to reach a hidden beach, take a boat trip in search of the elusive dugong sea creature, and participate in natural conservation by planting mangroves.
Venturing further afield across South East Asia, the pampering pleasures of Anantara Spa can be enjoyed by little ones too at Anantara Seminyak Resort & Spa in Bali, with manicures and pedicures and a chocolate facials designed for little princes and princesses. For the water babies, kids surfing classes with Tropicsurf are also available.
Travel to the Middle East and embark upon extraordinary desert and wildlife escapades. Surrounded by one of the world's largest deserts, the oasis retreat of Qasr Al Sarab Desert Resort by Anantara invites families to follow in the footsteps of ancient Bedouins and famous explorers. Set out across the endless towering dunes on a four wheel drive excursion that has been especially designed for families. Meet and greet a camel, or saunter along desert trails in a family procession.
Create a joint Arabian adventure by combining a desert stay with a nature and wildlife escape on Sir Bani Yas Island at Desert Islands Resort & Spa by Anantara. Follow free roaming cheetahs, sand gazelles, ostriches, rare Arabian oryx and stately giraffes with a four wheel drive through the vast Arabian Wildlife Park. Go horse riding at nearby Sir Bani Yas Stables, learn the age-old sport of archery, and make the most of the resort's seaside setting by kayaking on the shoreline of the Arabian Gulf. Return to rooms and suites that are fit for royalty, and admire the Middle East's magical sky with a family movie under the stars.
In the paradise of the Maldives, families can call the Indian Ocean their playground, reveling in action packed days both above and below the water. At Anantara Kihavah Villas a pirate cruise sails families to an uninhabited island to hunt for treasure and play Robinson Crusoe. Encounter the ocean's mesmerising marine life with a snorkeling trip, or watch the underwater drama unfold at the resort's unique underwater restaurant.
At Anantara Dhigu Resort & Spa, younger guests can learn about protecting the future of this unique Maldivian destination in a tailor made, fun filled educational excursion. At the resort's coral nursery children meet the resident marine biologist, who explains how coral grows to protect the pristine beaches and guard the island's crystal clear lagoon. Kids can touch and feel the coral, and also paddle across the shallow lagoon in glass bottom kayaks to look at the tropical fish, crustaceans and bizarre looking molluscs below, as well as a newly created reef with more than 450 different coral species.
Live out your family's holiday dreams, and so much more, with Anantara. For more information on all of Anantara's family fun activities please go to www.anantara.com


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VALLEY WALK: Local historian David Marrs will lead a guided walk around the Pont Valley on Sunday, January 6. Walkers will set off from Dipton Community Centre at 10am, then return to the community centre for homemade broth and cakes with tea and coffee afterwards. The charge is £2.50, with proceeds going to the Pont Valley Network for conservation and local history work. For further details, please ring 01207-570003.
COUNCIL MEETING: The next meeting of the finance and general purposes committee of Stanley Town Council takes place on Tuesday, January 8 at 6pm at the council offices on Lenin Terrace. The meeting will include discussion of the council's precept and grant funding.
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Opposition leaders call to fire Lebanese Interior Minister
A violent tremor has shaken Lebanon's ever-turbulent political arena as armed gunmen stopped a motorcade of prominent opposition leaders from reaching the Metn town of Btighrin, the powerbase of President Lahoud's in-laws from the Murr clan. According to Lebanese media reports on Sunday, the incident, which that took place on Saturday, has escalated the so-called "war of the two brothers" to yet a higher peak in the Metn since the June 2, 2002 by-elections collision.
The incident involved Michel Murr, former vice premier and interior minister who has long been a staunch ally of Syria and Gabriel Murr, Michel's younger brother and a bitter political foe, who won last year's by-elections on an opposition platform to President Lahoud's Syrian-backed regime. Victory at the polls was annulled by the nation's Constitutional Council and his MTV network shut down by a chain of court verdicts.
Elias Murr, Michel's son and Gabriel's nephew is the Lebanese Interior Minister.
According to A Nahar daily, Gabriel Murr hosted at his villa at Btighrin a lunch for prominent leaders who call to end Syria's 27-year-old presence in Lebanon.
Among those invited was Metn deputy Nassib Lahoud, the president's first cousin and political rival who has long been tipped as serious aspirant for the nation's top post. Also invited was the other Metn opposition deputy Pierre Gemayel.
When Nassib Lahoud's motorcade driving up from Beirut reached Btigrin's outskirts at Marjaba, it ran into road barricades with some 15 gunmen turning the car convoy back to Beirut in a hail of machine-gun volleys over the head of the presidential aspirant and his wife.
Gabriel Murr blamed the incident on Michel Murr's henchmen, demanding their prompt arrest. One politician, Fares Soaid, demanded the dismissal of Elias Murr as interior minister.
But the young Murr said he had immediately deployed 300 policemen in and around Btighrin who arrested six suspects within a few hours from the incident, including the man who is believed to have shot over the head of Nassib Lahoud and his wife, who is related to Saudi Arabia's Crown Prince Abdullah.
"I shall implement the law whatever the cost is on personal or family levels," Minister Murr was quoted as saying. "The war of the brothers that has ruined Metn will have to brought to an end and I am going to bring it to an end." (Albawaba.com)
© 2003 Al Bawaba (www.albawaba.com)
Top Headlines
- Opposition candidate beats government-backed competitor in Lebanese parliamentary by-election
- Lawyers: Confessions by Jailed Lebanese Opposition Leader False, Forced
- Tens of thousands at funeral of Tunisian opposition leader
- Report: Saudi Interior Minister Met with Iraqi Opposition Leader in Tehran
- BREAKING: Egypt fires interior minister


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|August 23, 2013, 03:51 PM
Senior Member
Join Date: April 1, 2013
Location: Midwest, USA
Posts: 323
Original stocks are not a problem for me either for .38 or 357. I actually prefer them to a rubber grips... I do mostly shoot .38, but whenever I put a box or two of 357 I do not notice any discomfort either.
I See Your Schwartz Is as Big as Mine! (с) Spaceballs
|August 23, 2013, 10:07 PM
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Join Date: November 28, 2004
Location: Silicon Valley, Ca
Posts: 7,117
Airman basic - back in my day (70's) if we got a new revolver or new checkered grips that felt too sharp, there was an old trick we used. Lay a quarter flat on the checkering and rub it around using your thumb. Just enough pressure to keep the coin flat. About five or six passes would flatten the tips of the checkering enough to prevent a bit or irritated hands.
Sevens- A Texas Ranger revolver? Is that one of the ones in .44-40? I'll be the first to agree that the Pachmayr Presentation grips do work well. Lots of police officers used them through the 60's and 70's (especially good in the rain when you've got slick hands).
Here's a real oddball type of K-frame grip you've probably never seen though.
These are Bianchi's "Lightning" grips, made for 2-2.5" K-frame revolvers. The grips include a metal insert that arcs up to shroud the hammer in the style of the S&W Bodyguard revolvers. It was supposed to ease the draw of the gun from under clothing. They didn't sell that well although some people did like the idea. The grips themselves feel very solid and stable in the hand and aid in getting on target quickly.
BillCA in CA (Unfortunately)
|August 25, 2013, 09:24 AM
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Join Date: July 28, 2007
Location: Central Ohio
Posts: 11,033
Whew, those are a bit hard on the eyes! But I can definitely see their usefulness. Bianchi did such tremendous business (and to a heap of LE) that they could afford to market a product that might otherwise get widely panned. I couldn't bring myself to put those on a Smith & Wesson, but I could definitely see how they might benefit someone who carried that revolver.
My 19-3 is a 1974 production "150 years of the Texas Rangers" commemorative. It's a blued, 4-inch .357 Magnum with a red ramp front sight and a trigger guard that has half it's width shaved along the forward half of it's arc. All of the stamping/lettering on the revolver is in gold and there is a 5-point star/shield of the Texas Rangers logo on the right side.
Smith & Wesson made something like 8 or 12,000 of these (IIRC?) and many came in the fancy wooden presentation case along with a large, heacy, gaudy knife that had a serial number matching the revolver. (they also sold the revolvers and knives separately as well) I do have the box and knife.
I got an extremely good deal on it and pretty much had no desire for any commemorative... I just wanted a nice Model 19, and this one absolutely qualifies.
If you look, you can find the revolver/knife/box set running anywhere from $600-$900. I do see them on Gunbroker and at shows on occasion.
Attention Brass rats and other reloaders: I really need .327 Federal Magnum brass, no lot size too small. Tell me what caliber you need and I'll see what I have to swap. PM me and we'll discuss.
|August 25, 2013, 02:52 PM
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Join Date: September 12, 2002
Location: Twin Cities, MN
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Airman Basic - I'm with you on the Pachmayr grips. In my younger days when I bought more handguns almost every gun that came my way resulted in a check to the Pachmayr catalog and an order. (I WAS smart enough though to keep the original grips around just in case I ever decided to sell something.)
|August 25, 2013, 07:43 PM
Join Date: August 7, 2011
Posts: 27
I would go for it. With a lesser offer of course, lol.
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Discussion in 'General Glocking' started by the monk, Nov 28, 2012.
I scored an American made G19 Gen 4 its sweet
I heard today that GLOCK is behind 1 year before they ship out anymore guns.
I just made a similar thread. Finally found one. If you look around hard enough you can find them. At this point though, you might have to spend a bit more.
How many 9mm guns does Glock make a year?
Does anyone really believe G19s will be outlawed in the near future? Maybe they'll come with 10 round mags, but I'm thinking the pistol will be unchanged. Why the panic buying? Is the 15 round mag capacity the drawing card?
When they get done a single shot will be illegal.
If they don't ship any, it's gonna take quite a large warehouse, to hold all of them.
I was at my local dealer last week looking for a G30 and he told me that Glock was shutting down production for 3-4 months to retool the factory. He wouldn't even attempt to try to order one. So I found one on my own 15 miles away
Wrong time to be thinking about shutting down for any length of time!
I heard they were a year behind in production.
I think your right.
Hey guys, I ordered a g17gen4 from my LGS on Dec 21. So far, they have no idea when it will be in. Does anyone here have any info on the wait times?
It would depend on what distributor they go through and when they get a shipment in.
I just put a 4th Gen G22 on layaway to match my G23. $409 with 3 mags at my LGS with the Mil discount. I figure if the ban gos through and I want to shoot cheaper I'll just get a 9mm barrel and 10 rd mags. I'll be watching the BS closely, if it comes up to a vote the credit card will get a work out
Local dealer vs internet rumor; I'll go with the internet rumor.
Just ordered G22 from CDNN. $399.95 with one mag. Said will ship Monday arrive next week....
Thanks, itisbruno!
LGS here in MD told me that they weren't expecting to get any 17/19 until March and most were spoken for.
My LGS (White Marsh, MD) had a number of G19s (Gen 3 and Gen 4) last week (I was only looking for G19s). I bought a G19 Gen 3 a week ago.
This LGS was the only place around here that had some on-hand inventory (all others had no idea when they would get some). He said that he and his partner had long-term close relationships with several suppliers, and getting product was not currently a problem.
Just sayin'...
Enjoy your new firearm Desert Duck. I got a G30 trade in from them a couple months ago and it truly was in excellent shape.
I tried to get a blue label 23 in Raleigh today. The shop called me back and said they couldn't get any until April...


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The visvim Windstopper Varsity Jacket has always been a favorite of ours, ever since the brand first released it a couple of seasons ago. For Fall/Winter 2010 the jacket returns in two colorways – dark grey/white and brown/white. The Japanese brand once again manages to present a classic piece of fashion that stays true to the original, while adding lots of new functionality to it. The jackets are now in stock from Union LA. (storeguide).
Take a further look at the jackets after the jump.


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Official Statistics
Older Workers Statistical Information Booklet: quarter 2, 2010
- From:
- Department for Work and Pensions
- Part of:
- Older workers statistical information booklet and Older people
- Published:
- 25 November 2010
Presents labour market data focusing on older workers (aged 50 to 64).
Older Workers Statistical Information Booklet: quarter 2, 2010
Ref: ISBN 978-1-84947-443-6 PDF, 1.1MB, 25 pages
This file may not be suitable for users of assistive technology. Request an accessible format.
If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email email@example.com. Please tell us what format you need. It will help us if you say what assistive technology you use.
DWP publishes the Older Workers Statistical Information booklet to meet a government commitment to publish information on employment statistics on older people.
The booklet presents employment statistics relating to older people (aged 50 to 64 and those aged 65 and above) in the UK. It covers a range of labour market statistics, including:
- employment
- unemployment and inactivity
- employment types
- qualifications
- industry
- occupation
Key statistics are compared by age, gender, ethnicity and disability. The booklet also includes supplementary statistics on the impact of the recession on older workers over the last 3 reporting years.
The majority of results presented in this booklet are based on Labour Force Survey (LFS) data for the UK in quarter 2 (April to June) 2010. The LFS is a representative sample survey of 60,000 private households in Great Britain and Northern Ireland.
Document information
Published: 25 November 2010


text:
The Cable
Gration: No vote in Abyei, possible delay in Southern Sudan referendum
A whole host of U.S. officials are on the ground in Sudan, working tirelessly to encourage that two votes scheduled for early January are conducted on time and fairly. But the top U.S. official in Sudan said on Monday that at least one of the two votes will not happen as scheduled, and that the ...
A whole host of U.S. officials are on the ground in Sudan, working tirelessly to encourage that two votes scheduled for early January are conducted on time and fairly. But the top U.S. official in Sudan said on Monday that at least one of the two votes will not happen as scheduled, and that the other could now be delayed as well.
In the main referendum scheduled for Jan. 9, the citizens of oil-rich Southern Sudan are due to decide whether to remain united to the Northern Khartoum-based government or separate to form their own country. In the second poll, the citizens of the resource-wealthy province of Abyei are supposed to decide whether they want to be part of the North or the South — if the South does vote to secede.
U.S. Special Envoy to Sudan Scott Gration said on Monday on a conference call from Khartoum that due to problems setting up the vote in Abyei, that vote will not happen on Jan. 9 as had been hoped.
"We've passed the opportunity for there to be a poll," Gration said, citing disagreements over voter eligibility that led to delays in setting up the logistics of holding a referendum in Abyei. He said the issue was in the hands of the two parties, but that the United States was "encouraging them to do what it takes to get a solution before the end of the 9th of January."
The revised goal appears to be somewhat less ambitious, but no less critical: if the outstanding issues in dispute in Abyei are unresolved before the South votes on Jan. 9 — and if the expected outcome of secession hold — both sides could claim ownership of the province and violence could erupt.
"We are working with both sides to calm the rhetoric and put a plan in place that will give both sides reassurances," Gration said. "This is probably not a situation where either side will be happy. We're looking for a solution that leaves both sides angry but neither side mad."
A senior U.S. official, speaking on background, said that the Abyei situation was extremely tense and represented the greatest risk of violence in the near term. If Abyei breaks out in violence, it could threaten the overall Southern Sudan referendum, the official said.
"In terms of violence that would upset the (Jan. 9) referendum, Abyei could be a flashpoint that would be disturbing enough that there would be cause for a delay," the officials said. "It's important that the (Sudanese) presidency come out with some roadmap, some solution, that the people in that area know what their future is going to be."
Of course, even without a breakout of violence in Abyei, the referendum in Southern Sudan might be delayed anyway. Gration said that although the technical preparations in Southern Sudan were going well, legal challenges to the referendum could result in a delay.
Southern Sudanese leaders have been flooded in recent days by complaints and legal challenges intended to derail the referendum, a campaign they claim is an organized effort supported by the government in the North. One of the complaints, for example, is that time periods for various stages of voting were not strictly adhered to.
Gration admitted that the voter registration period and the time between registration and voting had been compressed.
"Therefore the Southern Sudan Referendum Act was not totally complied with in order to reach the date of Jan. 9… We think it's a good trade off," Gration said. "It really didn't change the outcome and it hasn't changed the transparency."
Another senior U.S. official said that there are no "technical" barriers to holding the referendum on Jan. 9, but acknowledged the political problems. He estimated the odds of holding the vote on time at "greater than 50 percent."
But the official admitted that even a short delay in the overall referendum could cause huge problems in Sudan.
"That would be a serious political crisis if there were any serious steps to delay the referendum," the official said.
John Prendergast, the CEO of the Enough Project, said that the key to peace is to fold the sensitive Abyei negotiations back into the larger deal that is being pursued between the North and South on a host of issues, including borders, citizenship, and wealth sharing.
"Tradeoffs and compromises are critical at this juncture," he said. "For the overall deal to work, Abyei is going to have to be transferred to the South, using the borders outlined by the Permanent Court of Arbitration. But the Arab Misseriya population is going to have to have a minority role in governing arrangements in Abyei, along with guaranteed grazing rights along traditional migratory routes. Both sides are going to have to give in order to avert war, a war in which everyone would lose badly."
Gration also announced that Ambassador Dane Smith will join the U.S. delegation in Sudan to be the point man for the Darfur issue, which some analysts are concerned is worsening as attention focuses on other parts of the country. Gration will travel this week to Doha for a multilateral meeting on Darfur.
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Opportunities Reporting Subject Area
This subject area is available in all editions of Oracle CRM On Demand.
Business Purpose
This subject area allows you to analyze opportunities by account, territory, campaign, contact, territory, owner, and date dimensions. This subject area is a multi-fact subject area that includes opportunity and quota metrics. Opportunity metrics are defined at the most granular level in this subject area, and hence, can be analyzed by every possible dimension. However, Quota metrics are at less granular level and can be analyzed only by limited dimensions including Date (Month), Quota, Owner.
Relationship Type
Optimized Filtering Fields
This subject area has fields that are optimized for reducing the query time when they are used in filters. Optimized fields end with the words Code or UTC. For example, the Account dimension has an Account Type field. There is also an Account Type Code field, which is the optimized version of the Account Type field. Similarly, there is a Last Call Date UTC field, which is the optimized version of the Last Call Date field. Using the optimized field in the filter generates faster queries. This method is faster than using the standard field. For information on using optimized filtering fields, see Using Optimized Filtering Fields. The following dimensions in this subject area have optimized filtering fields:
The following are the key metrics in this subject area:
The complete list of metrics for this subject area is as follows:
Usage Notes
Because quota metrics are not defined at the Opportunity dimension level, these metrics are displayed as empty cells when Opportunity dimension attributes are on the report.
The Account dimension includes a Book hierarchy, which enables you to analyze metrics and related attributes at any level.
|Published 5/4/2012
|Copyright © 2005, 2012, Oracle. All rights reserved. Legal Notices.


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That makes three of us, but I assumed, given Bruno's follow up remark about "pussy cat" and Karina's reaction that it was an uncouth reference to a part of a woman's anatomy. Am I correct?
Printable View
Well, they're making it predictable who they want gone, just like I figured. I know Ralph's too nice for this, but he and Karina should go out during the cha cha challenge and give them all the finger. I mean, that's what they're doing to them. Bruno isn't as great or funny as he thinks he is. They aren't going to win the cha cha, why not call them out during it.
i think bruno said something to the effect that ralph "was a little too rough with the p---y."
he was bleeped, but then tried to amend his comment to "pussycat." by then, karina was really ticked off and told bruno "classy."
^Yep, that was it. He didn't need to say that at all.
Tom: "And by the way, we have to thank the Bert Lahr estate for Karina's wig.":lol
there goes ralph again -- complaining about being the under-appreciated underdog.


text:
Artist description:
i definitely feel good about this one....its very surrealist...
Canvas Draw Created Apr 03, 2012 640 x 460px Unless noted Copyright 2012 nirvanaspirit666.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
-cough- Should I even try to comment on anything ever again after grimmjow2009 there?
cool drawing, is it an alien?? 5/5
(4) imagination and colour. Overall, very though-provoking but also lacking thereof.
(3) achored to the contrasting darkness on the right, which would represent the real world in all it's melancholy. I would say, however, that the colours are pretty constricted. Only blue and white? Surely our minds would explode with a spectrum of
(2) The 'eye' could be the minds eye, the eye of imagination that we gaze through to see a world within ourselves, gaze at the immense explosion our minds. I also feel this as the eye is almost 'plunged' into the depths on the left, while still being
(1) The piece... doesn't give of a particularly 'powerful' feel, but definately immense, heavy. There's alot of activity yet no physical movement. It provokes thoughts of the imagination running free, yet still trapped within our heads.
you are realy special:)
Like a one-eyed octopus from space. Love it! 5/5 collection


text:
Simon Guckert
Found 10 Records, 9 Photos and 4,918 Family Trees
Born in Hesse Drm on 1828. Simon married Barbara Guckert and had 7 children. He passed away on 1907.
Family Members
Ready to discover your family story?
Simply start with yourself and we'll do the searching for you.
Potential photos and documents for Simon GuckertView All 9 Images
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Surname meaning for "Guckert"
South German: variant of


text:
Articles from RotoWire's fantasy archives that mention Jordan Hill's name.
July 2, 2015
2015 Team Preview: Seattle Seahawks
Russell Wilson now has star tight end Jimmy Graham at his disposal. Will that be enough to take the Seahawks offense to a new level and a third straight Super Bowl?
January 15, 2015
Game Capsules: Breaking Down the Conference Championships
Tom Brady and the Patriots look to get back to the Super Bowl, and the only thing standing in the way is Andrew Luck and the Colts in the AFC championship game.
August 23, 2014
Fielkow's Law: Blounted Ballers
Le'Veon Bell and LeGarrette Blount's off-field trouble this week might not become a headache for fantasy owners for quite some time.
June 24, 2014
2014 Team Preview: Seattle Seahawks
Win Forever?
January 28, 2014
Mock 4.0: Watkins and Carr Combo for Oakland?
The rebuilding Raiders need to find a quarterback and a supporting cast to help him out. Can Oakland land two top talents early on?
June 25, 2013
2013 Seattle Seahawks Team Preview: Harvin Bolsters Seattle Attack
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Junior Member
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X10i stuck at SE logo after downgraded it by using azuzu flashtool
hi, I am new here. I need a solution of my phone, model x10i. It stuck at SE logo after using Azuzu flashtool. Actually, I want to root my phone but I failed and now, I really want my phone back as usual. any solution?


text:
Problem: Corroding Tailgate Cables
Units Recalled: 4 million
In 2004, GM recalled nearly 4 million pickups and SUVs because of corroding tailgate cables. The galvanized steel support cables would weaken and eventually fracture on certain Silverados, Sierras and Escalades, causing the tailgate to suddenly drop and strike the rear bumper.
(Sources: U.S. National Highway Traffic Safety Administration; Reuters; InternetAutoguide.com)


text:
The Pennsylvania Medical Pay Act requires employers to bear the costs of employee medical examinations when those exams are a condition of employment.
The law covers all Pennsylvania employers and prohibits forcing a job applicant to pay for any medical testing that is a condition of employment. Similarly, employers must bear any cost necessary to produce medical records.
Employers found guilty of violating the Medical Pay Act face a fine between $10 and $100 for each offense.
Remember that the Americans with Disabilities Act has special provisions for post-offer and pre-employment medical exams and necessary testing. Be sure to coordinate those rules with the Pennsylvania law that requires you to foot the bill.
For example, if you require an applicant to obtain a doctor's certification that he or she has had necessary immunizations, be sure to pay the charge for reproducing the records.
Excerpted from


text:
Artist description:
phewwww this is hard
Flash Draw Created Jun 07, 2009 470 x 338px Unless noted Copyright 2009 Sketcher.
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FreakyA Jun 07, 2009
ya know...loking at 13 of ur draws making me feel all tired...think i'll go for a little break now xD
tink8 Jun 07, 2009
yay!! it has begun.
sadik Jun 07, 2009
hard? hahahaah
Page 1


text:
Daniel Sturridge's agent reportedly approached Arsenal about signing the striker on deadline day, only to be shot down by Liverpool.
Speculation emerged around midday on Wednesday suggesting one of the England international's camp had been in contact with the Gunners, proposing they sign him on loan for the remainder of the season.
The proposal came about due to Sturridge's growing frustration at his lack of game time at Anfield, with the 27-year-old having been left on the bench until the final two minutes of last week's 1-1 draw with Tottenham.
Sturridge supposedly grew up an Arsenal fan and would have loved the chance to make the move to the Emirates Stadium, according to Goal.com.
However, Reds boss Jurgen Klopp was quick to shut down any idea that Sturidge had about leaving, while it is unclear whether Arsenal were ever seriously interested in the suggestion.


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Eink vs LCD: Is what Amazon says true?
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LB's lolz Mutt Minion
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^ Hmmm, good info re: the lighted cover. I am now glad I didn't purchase that one.
I have not found this to be the case with my K3. The light I purchased is a single AAA, single lamp and the head unit has a light diffuser lens. On my K3, the light is very evenly dispersed across the entire screen. There is a tiny bit of glare/reflection at the 12 o'clock position but this only impacts the first couple of sentences in that specific area but even this can be reduced with an ever so slight, momentary tilt of my K3.
Certainly not quite as elegant a system as the lighted cover, but I can deal with the small inconvenience of carrying a separate light.
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text:
State of Africa
To the Editors:
We criticize Africa for its political and economic problems [Jan. 16] but fail to consider what the U.S. was like on its 25th anniversary. In 1801 many Americans were illiterate. Transportation was poor, and the nation had a weak central government, minority problems, strong regional loyalties and was dependent on foreign allies. Taking a cue from our own history, we should give Africa more time to deal with its woes.
Steven C. Foshay Boonton, N.J.
Senegal's Leopold Senghor says, "The colonizing powers did not prepare us for independence."...
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text:
CARLSBAD —— Some residents of Carlsbad's Barrio neighborhood are upset that a portion of an eight-block fence going up along the east side of the railroad tracks from Oak to Tamarack avenues will block their access to the beach and cut into their property values.
The city is building the fence as part of a regional Coastal Rail Trail project, a 44-mile biking and hiking trail along the railroad tracks from Oceanside to San Diego.
Specifically, residents said this week they are displeased by the portion of the fence to be built along Chestnut Avenue, in an area they say Barrio residents have used for decades to cross the tracks to get to the beach.
"Literally, generations of people have been crossing there," said Michael Hedrick, a Madison Street resident. "There's a path worn into the ground. It's been going on for decades."
It's also dangerous —— and illegal —— to cross railroad tracks where there is no sanctioned passage, countered a spokesman for the North County Transit District, which owns the train corridor.
"We can never condone illegally crossing railroad tracks," Kelleher said. "That's how people die. I can't be any clearer than that."
He added that people caught crossing the tracks at Chestnut Avenue or any other illegal area face verbal warnings, citations and fines.
Hedrick, the Madison Street resident, said he moved to the neighborhood and bought a separate rental unit in the area specifically because of the quick access to the beach at Chestnut.
Madison Street resident Bryan Batten echoed Hedrick's sentiment.
"(Beach access) was the clincher for me buying my house here," said Batten. "It was the last affordable neighborhood in Carlsbad with beach access."
Currently, there is a temporary chain-link fence at the end of Chestnut Avenue protecting a construction site, but that temporary barrier will eventually give way to a permanent 6 1/2-foot-high fence after the city finishes its rail trail.
Hedrick, Batten and other residents said they understand that there needs to be some kind of a barrier to protect people using the rail trail from trains, but say the city should build or push for a pedestrian crossing at Chestnut Avenue to let residents cross the tracks safely.
Hedrick singled out the Rosa Street pedestrian bridge being built over the railroad tracks in Solana Beach as a good model for a Chestnut Avenue crossing.
"I think it's time for the city (of Carlsbad) to think about it," Hedrick said. "But they have to have the political will to spend the money to do it."
Batten said a simple swinging gate would work just as well, saying any crossing doesn't need to be elaborate or expensive.
Batten and Hedrick explained their concerns to the City Council last week and have been passing out fliers to Barrio residents to get word out about the fence. And Barrio resident Max Rabii, who owns several rental properties on Chestnut Avenue, said he is collecting signatures on a petition calling for a pedestrian crossing.
A city official said building a crossing would be a long and expensive process. And the idea for a Chestnut Avenue crossing has been shot down before.
"I don't think people understand what this kind of project would involve," said Sherri Howard, the associate city engineer in charge of Carlsbad's portion of the Coastal Rail Trail project.
Howard said the city doesn't own the train corridor —— the North County Transit District does —— and even if the transit district wants a pedestrian crossing, it would need to be approved by both Amtrak and Burlington Northern Santa Fe Railway.
And any crossing project would have to be approved by the California Public Utilities Commission, the Traffic Safety Commission and the California Coastal Commission, among other agencies, she said, noting that it would also have to comply with numerous regulations, such as the Americans with Disabilities Act.
Howard said that without a specific design, it would be premature to talk even about how much a crossing might cost, but she said "it would be very expensive and it would take several years."
Howard pointed out that several years ago, the state utilities commission rejected a proposal for a Chestnut Avenue crossing for safety reasons.
Transit district spokesman Kelleher agreed with Howard that it would take enormous amounts of time and money to get a crossing built —— but it's not out of the question.
"We are willing to work with any city along our right of way that would like to look into pedestrian crossings," he said.
As for residents who are complaining that they now have to walk an extra half a mile to cross the tracks at designated crossings —— at Carlsbad Village Drive to the north or Tamarack Avenue to the south —— Kelleher said that's what they should have been doing all along.
"I don't mean to be uncaring about citizens, but we really want to ensure safe operations," Kelleher said. "You don't see people running across an airport tarmac.
"This is the same thing. (Chestnut Avenue) is not a safe place to cross."


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Some guys, you just look at and you know they're destined to be football players. McCluer North defensive tackle Keith Williams falls into that category. As a junior in high school, Williams is 6...
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IMPORTANT REMINDER: All messages must be signed with a minimum of your first initial and last name.
I think those seals were originally leather. I remember using a piece of leather cut to size and soaked in oil on my '37. It worked. Harry
For sealing the counter shaft and reverse idler shaft use cork gasket material cut to fit the square groove and your favorite sealant.
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