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Reddin keeps Saints solid start alive
St Maur's 3-6
St Judes 0-14
DUBLIN forward Ciaran Reddin popped up with a late point for Maur's as they made it two wins from two at Rush on Sunday morning.
Reddin, although playing a full half for Dublin at the weekend, still had the legs to take a pass off Mikey Reilly with a minute to go, and having beaten a couple of defenders, he slotted over a terrific score to avenge last season's defeat to the same side.
Reddin's inclusion was a welcome one for Maur's who were down a number of first-team regulars.
Nonetheless, they showed great fortitude to get back into the game after the Tymon Park men had built up a handy lead at the end of the first half. With Stephen and David Carthy joining older brother Chris for the last 20 minutes, Maur's had the momentum to secure the victory.
Judes, while missing in-form Dublin forward Kevin McManamon, brought a strong team down with them and one of the key duels of the game was between Kevin's brother and Padraig Butterly. The Maur's man would win that duel and overall the home side's full back line acquitted themselves well on the day.
They had their work out cut out containing the visitors, but a penalty on five minutes from Chris Carthy after Conor McGuire had been dragged down inside the box was to draw Alan Durnin's men level.
Judes found another gear to lead by 0-9 to 1-1 at half-time and they looked comfortable until great combination play between McGuire and Carthy saw the former finish past the keeper. That brought Maur's back to within a point, but the introduction of Gareth Weldon was to prove a turning point for the home side.
With Vinny Whelan introduced at full forward to give Maur's a bit of height inside the square, they were to open Judes for a second time. The former Dublin under-21 offloaded to McGuire and he duly fed to Weldon who showed great composure to finish past the keeper.
That put Maur's a point up, and while McManamon was to level off a free, Reddin then struck for the winning score of the game.
Best for Maur's was David Carrick who gave arguably his best game ever for Maur's at left half back.
ST MAUR'S: Mark Butterly, Ciaran Sweetman, Niall Walsh, Padraig Butterly, Eoin Fletcher, Barry Moore, David Carrick, Mikey Reilly, Ciaran Reddin 0-2, Barry Cronin, Chris Carthy 1-0 penalty, David O Donnell 0-1, Cathal Sweetman, Kevin Watson, Conor McGuire 1-3 (0-2f). Subs: David Carthy for Barry Moore, Gareth Weldon 1-0 for Barry Cronin, Vinny Sweetman for for Cathal Sweetman (black card), Stephen Carthy for Kevin Watson.
St Pats Donabate 4-8
Ballymun Kickhams 2-14
ST PATRICK'S Donabate showed great spirit to rescue a point against 2013 All-Ireland Club champions Ballymun Kickhams on Sunday morning.
While missing some notable players in Jude O'Sullivan, Colin Murphy and the two Corcorans, Donabate dug deep into their resources to pull the game out of the bag, with Dean Styles landing a late free to earn the draw.
Certainly, after losing by the narrowest of margins to Parnells, this was a big result for Pats given the opposition.
While missing their Dublin stars on the stay, Ballymun still had plenty of quality on the pitch, with Ted Furman, Kevin Leahy and Jason Whelan all featuring up front for last year's beaten county finalists.
Donabate, after conceding two early points, were to edge in front on five minutes when Niall Collins coolly slotted past the keeper after an infringement on Paul Knight inside the square. Knight was the star performer for Pats and in the absence of Dinny Corcoran has certainly flourished in the full forward position.
The former Newcastle United apprentice produced some brilliant flashes during the game and on 12 minutes collected a long ball before drilling past the keeper to double his team's advantage - 2-2 to 0-4
John Lynders was another to stand out, although his influence diminished somewhat under some heavy hits from a well-drilled Ballymun defence and by half-time Kickhams had turned the screw to lead 2-3 to 1-7 and added two more points to their tally after the break.
Again, though, it was Knight who came to Donabate's rescue when, having collected a long ball, he raced clear of his marker before shooting past the keeper.
A terrific team move was then to see Conor Dowling raise the white flag, but mid-way through the half Ballymun still held a three-point lead before Lynders showed great athleticism to fist the ball past the keeper after a long ball had been played into the square - 2-10 to 4-4.
Ballymun attempted to pull away once more, but points from Ciaran Stone, Knight and Collins were to keep Donabate on an even keel with full-time approaching.
Kickhams were then to edge back in front, albeit off a harshly conceded free, and it looked at that stage that they might get the win, but underlining his team's great determination, Knight won back possession on the end line and engineered a free on the right-hand side.
And while faced with a difficult angle, Styles hit the ball perfectly between posts to cap off a terrific performance from Pats.
St Pat's Donabate: James Foran, Adam Darby, Darragh Mahon, Michael Lynders, Thomas Murphy, Joey Collins, Conor Dowling 0-1, Dean Styles 0-1(f), John Lynders 0-1, Sean Keogh, Niall Collins 1-3 (1-0 pen), Shane McGrath, Wayne Knight, Paul Knight 2-2, Ciaran Stone 0-1. Subs: Colin Riordan for Dowling, Liam Watson for McGrath, Brian Keegan for Stone.
Raheny 0-10
St Sylvester's 1-5
ST SYLVESTER'S boss Robbie Brennan believes that youth is the way forward for his team, despite seeing them slip up at home to Raheny at Broomfield on Sunday morning.
The former Kilmacud Crokes man handed starts to Under-21s John Peacock and Jack Hazely, but it was to prove a frustrating morning for the Malahide men.
A late Micael McCarthy penalty gave the home side some hope, but Raheny held on to maintain top spot in the division.
With two months to go before their big championship clash with St Maur's, Brennan insists that everyone will be given the chance to prove themselves.
'You look at that team, they have been involved in the Dublin underage panels and at some stage you have to start looking to introduce some young lads and get a nice blend into the panel.
'We are still in the same process of trying to give everyone the chance to stake their claim for a place in the championship and I thought it was good to see the likes of Jack Hazley properly exposed at that level for the first time.
'But it just didn't happen for him or the other guys on the day, which is disappointing after our display against Raheny.
'We were missing a few lads, but we have David Galvin and Aidan Relihan to come back and John Coughlan is back doing a bit of running, so we are slowly but surely getting back towards our full squad.'
Brennan is certainly relishing the prospect of taking on Maur's for the first time as manager.
'It will be my first experience of playing Maur's and I suppose if there were two teams you wanted to avoid in the first round, one was Maur's and the other was Crokes who drew Plunketts.
'But overall we are delighted with the draw. There is a huge history there, so it's going to be a nice humdinger.
ST SYLVESTER'S: Stephen Finnegan, John Peacock, Fionn Carney, Barry Ryan, Glen Hazley, Liam Murphy, Ciaran McArdle, Ross Hazley, Shane O Connor, Conor Meaney 0-1, Gary Sweeney, Jack Hazley, Ciaran Roche 0-1, Michael McCarthy 1-2(1-0 pen, 0-1f), Eoin Fanning 0-1. Subs: Colm McIntyre for McArdle, Ronan Palmer for Conor Meaney, Alan Foy for Jack Hazely, Stephen Cunningham for Ciaran Roche.
Fingal Independent


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Athletic directors from K-State and Mississippi State schedule football series on Twitter
There are snark tweets, funny tweets, troll tweets and, of course, the OMG-LeBron-James-is-going-back-to-Cleveland tweets. But what about using 140 characters (or less) to set dates for future college football games?
It happened.
What started as some good-natured fun between athletic directors ended up in an agreement to meet on the gridiron.
Kansas State AD John Currie got the conversation started when he took to Twitter on Friday morning with a video to challenge Mississippi State AD Scott Stricklin for the "Chillin 4 Charity" campaign. (Basically, you challenge people to pour water on their head in the name of charity.)
Currie stated in the video, "We think that Mississippi State ought to come here at Bill Snyder Family Stadium and play a little football sometime."
From there, the two started talking shop, hashtags included.
#Chillin4Charity @stricklinMSU We have raised the bar in this effort! Enjoy the video: http://t.co/2HDP4vEOd1
— John Currie (@John_Currie) July 11, 2014
@stricklinMSU @HailStateFB Already got some stuff working then – how about '18 MHK, '19 Starkvegas? #KState #Family
— John Currie (@John_Currie) July 11, 2014
Let's do it! RT @John_Currie: @stricklinMSU Already got some stuff working then – how about '18 MHK, '19 Starkvegas? #KState #Family
— Scott Stricklin (@stricklinMSU) July 11, 2014
So, @HailStateFB vs @KState_Football: '18 in Manhattan; '19 in Starkville. Pleasure doing business with you, @John_Currie. #HailState
— Scott Stricklin (@stricklinMSU) July 11, 2014
@HailStateFB @KState_Football 'Cats and 'Dawgs tweeting together! Let's get the paperwork done! Have a great weekend @stricklinMSU
— John Currie (@John_Currie) July 11, 2014
Nothing is officially official, of course, until the contract is signed. But all tweets point toward the SEC-Big 12 matchup, with the Bulldogs visiting the Little Apple in 2018 and the Wildcats traveling to Starkville, Miss., in 2019.
This has to be the first time a major-college football game was scheduled using social media, right? #Awesome.
FOX Sports Go
Today 12:30a ET The Ultimate Fighter: A New World Champion - Predator
Today 1:00a ET Everton vs. Atalanta REPLAY
Today 1:30a ET The Ultimate Fighter: A New World Champion - Enjoy the Moment
Today 2:30a ET The Ultimate Fighter: A New World Champion - Sink or Swim
Today 3:00a ET UEFA Champions League Highlights

subset: commoncrawl


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To paraphrase one of the great works of science fiction, the internet is big. Really big. I mean, you wouldn't believe how mind bogglingly big it is.
But you can make it seem much smaller by setting up a virtual private network (VPN), which reduces it to the size – or at least structure – of a domestic LAN. Why would you want to do that? To make your games run better, of course.
Reducing lag
Not only is the internet big, there's no easy route across it from A to B. It's all jumps and hops from one node to another following paths that are criss-crossed all over the place. There aren't many direct ways for packets of data to get from one place to the other. And yet it's possible to connect to a games server on the other side of the world and send information to and fro so quickly you could kid yourself that you're playing on a machine in the same room. Most of the time, anyway.
Sadly, not all games work quite as well over the internet as they should. Writing good netcode is difficult at the best of times, and if it's just not a priority for the developers, well, budgets have always been tight and some things get overlooked.
Lag, latency and dropped packets can result in a terrible gaming experience if all you want to do is get together with a few friends for a multiplayer game of Battle for Middle Earth, for example.
With some games you can have the fastest broadband connection in the world, but getting them running over the public internet can be an impossible task. Often, the problem is associated with the way the interface between your local network and the internet at large is handled.
Every machine on a network is identified by an IP address, a series of numbers that appear in the format 123.456.78.9. The problem that many games have is that the IP address which your PC announces to the internet isn't actually it's own address at all – it's your router's.
Your router acts as a kind of bridge between your home network and the internet at large, but it doesn't put all of your computers onto the internet – it shares one address among them all, and issues separate addresses relevant only to your LAN to every device around your home.
Games that are designed to work well on a LAN often stumble when trying to connect computers. Often, this can be cured with port forwarding. For some games, however, smooth online play requires a lot of ports to be forwarded, and since each port that's forwarded through a firewall is a potential security risk, it's not an ideal situation to leave your PC in.
Neverwinter Nights 2 – a game that's best played with friends – requires over 100 ports to be left open if you want to play. Good security practice would dictate that you close them between games (and some dedicated gaming routers can do this automatically), but that's not going to happen, is it?
Your own network
Fortunately, there's another way to get around the problems of address translation between internet and your network. Just invite everyone you're gaming with to join your own LAN.
Paradoxically, they can join your local network over the internet. To get around the issues of opening up holes in firewalls for remote workers, many businesses operate virtual private networks or VPNs. These create all the conditions for an IP-based LAN, but use the hardware of the public internet.
Computers connect to the VPN using special tunnelling protocols for point-to-point communications, and once on behave as if they're connected to a LAN. Anyone with the right security credentials can log into the VPN, and once you're in all traffic acts as though there's a direct physical connection between yourself and the LAN host.
A VPN is still at the mercy of latency and lag introduced by the distance and dodgy IP nodes innate to the internet at large, but it neatly sidesteps routing and firewall issues. Older games which were designed for LAN multiplayer rather than the internet will work better over a VPN, for example, and you'll spend less time fiddling with router settings.
Even with newer games, VPNs are worth brushing up on. It might surprise you to know that even though modern games are often designed with internet play in mind, they still work much better over a LAN. Dead Island is a good example here – and coincidentally the game we'll be using for our walkthrough.
VPNs are also popular with pirates who want to get around online authentication by setting up a fake master server on a virtual network for key authentication in multiplayer games amongst friends. There are more legitimate reasons for setting up completely private servers – to avoid downloading automated patches in games that connect to internet master servers, for example.
Judicious use of Google will also throw up ways to run illicit servers for those new shooters and RTS games that insist on spawning servers for you, over which you have little or no control. And because you can, of course. What better reason is there than that?


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- scrappy_day Said:
I just put Christmas scrapbook paper on them with flat embellishments and then coated everything with mod podge. When that was dry, I sprayed them with clear spray paint and then put cork on the bottom. They turned out really cute. Everyone loved them. And they made cheap little gifts.
That does sound cute!


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It was a near miracle of timing and convergent strategies within Quebec Inc., the faltering government-corporate-union collaborative economic model once portrayed as the solution to the province's economic development problems.
On Wednesday morning, two major Montreal corporations and the Quebec government popped up to set the stage for a full revival of the idea that business and government are corporate partners in the grand scheme of building the economy of the future. All they need now is the federal government, which appears set to join in to create an all-new version of Quebec Inc.
Out of the blue came Bombardier and Air Canada to announce that the airline had signed letters of intent to buy 45 of Bombardier's CS300 aircraft with options for another 30. With that, struggling Bombardier — its shares trading at penny-stock levels — can claim to have finally sold the CS300 to a "mainline international network carrier."
Next miracle: the Quebec government dropped its four-year-old lawsuit against Air Canada for failing to keep heavy aircraft maintenance operations in Quebec and Canada, allegedly in contravention of federal law. Just last month, Air Canada announced it was taking the case all the way to the Supreme Court. But now, suddenly, the case is settled and the airline has agreed to maintain the C Series in Quebec for the next 20 years.
No dollar figures were announced, but the news almost overshadowed Bombardier's announcement that it would be laying off 7,000 workers worldwide. Did I say layoffs? In the corporate biz-speak of the day, Bombardier said it is engaging in "global workforce optimization" that just happens to involve reducing employment by slightly more than 10 per cent of the company's workforce.
Ironically, almost half of the "optimization" will take place within Bombardier's transportation division, the rail and train maker, which recently received a $1.5-billion cash injection from the Caisse de depot et placement, the province's pension plan, as part of an expanding Quebec Inc. effort to save Bombardier. At the time, the Caisse's investment was said to be providing a "nice safety net" while guaranteeing a fat 9.5% return to the pension fund. The safety net obviously does not apply to all employees.
The next big government infusion is expected soon from Ottawa. Alain Bellemare, president and CEO of Bombardier, made it clear that the company is counting on the Trudeau Liberals to follow the Quebec plan. Last October, the province put up $1 billion to fund the struggling C Series.
In a teleconference session Wednesday, an analyst wondered whether Bombardier still needed Ottawa's help since the company is now sitting on $6.5 billion in cash. Bellemare said Ottawa would be providing a useful boost to cash and confidence.
First, Ottawa's endorsement would help the company and airplane buyers to "regain confidence" in the C Series. "We are looking forward to seeing the federal government coming into the program as an equity partner."
Bellemare said discussions with Ottawa are "ongoing" but he wanted to "be careful as to what we're communicating and saying publicly. But we all think that the federal government would come very close to what Quebec did." Quebec took an ownership position, he said, and "we hope that the federal government will do something similar."
When that does happen, the effective equity owners of the C Series project will be Ottawa and Quebec. The analyst then raised the tricky financial accounting question of how Bombardier would account for the C Series project on its books if the governments essentially owned the company? Bellemare said that little accounting problem had not yet been resolved.
The convergence of Quebec Inc. around Bombardier is now substantial: $1 billion from Quebec for airplanes; $1.5 billion from the pension plan; another $1 billion from Ottawa; a new airplane order nominally worth $3.8 billion from Air Canada.
Air Canada says it was not forced into the CS300 deal by any government. Since the planes are said to be state of the art, that may well be true.
To hear Bellemare talk about Bombardier, one might wonder why the company needs all this government help. "We are turning Bombardier around," he said, "getting traction" with a "strong footprint" and "building momentum" while "re-sizing our manpower to match future workloads." As a "global market leader" the company is "driving efficiency in all sectors."
In other words, it's all good — especially when the objective is to sell the Trudeau government on the merits of keeping an old economic idea alive.


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Medical Definition of Bruit
Bruit: A sound heard over an artery or vascular channel, reflecting turbulence of flow. Most commonly, a bruit is caused by abnormal narrowing of an artery. Listening for a bruit in the neck with a stethoscope is a simple way to screen for narrowing (stenosis) of the carotid artery, which can be a result of cholesterol plaque accumulation.Source: MedTerms™ Medical Dictionary
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SACRAMENTO (KCBS) – New state figures show that nearly one out of every five California high school seniors dropped out last year, with the numbers even worse in Oakland.
For years, the state's dropout rate has ranged from 11 to 22 percent, but the tracking system used was not completely reliable.
The new method tracks students over their four year high school career and the first results show that three out of four students who started high school in 2006 graduated with their 2010 class. But more than 18 percent dropped out.
KCBS' Holly Quan Reports:
And in Oakland, only 53 percent of the 3,200 students that were tracked managed to graduate, with 37 percent dropping out.
State Superintendent of Public Instruction Tom Torlakson said it is never too early to start cracking down on attendance.
"In the Los Angeles School District, 23 percent of kindergartners are chronically absent. That means they are missing 20 or more days of the school year. In Oakland, it's 17 percent," said Torlakson. "That translates into year's lost time. By the time you're a ninth grader, you've lost one year of your education."
Perhaps even more startling is that more than 17,000 eighth graders dropped out before they even entered grade nine.
(Copyright 2011 by CBS San Francisco. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.)


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INDIANAPOLIS—As I left for Indianapolis, my wife issued a warning:
"Better not find any girls there!"
I guess a certain low-level professional golfer's scandal had her worried. I could've simply told her that in five and a half years of professional baseball I'd never cheated, but instead I went another route. "I'll probably be surrounded by men," I said.
I expected females to be trace elements at baseball's Winter Meetings, but as I rounded the steps leading to the expansive lobby of the Marriott Hotel, a song began playing in my head:
"It's raining men! Alleluia! It's raining men!"
It really was incredible. A sea of men overtook me.
I took a seat near the bar, and, like a lurching 14-year-old boy, began counting the number of women that I saw: 1, 2, 3 . . . 4 . . . 5 . . . ah, a sixth across the room (perhaps Kim Ng?). I counted less than 10 in about a five-minute search. There were at least 200 people in the room.
I quickly gave up this search, for my wife called me in the middle of it. It was as if she knew my actions.
The game of baseball is played by men, so I guess one would naturally expect more men running it. But a 20:1 ratio?
I left the bar and walked up the steps to the press area. Here I found more men. Only a few female journalists scattered about. The whole place was a bratwurst fest that would've made any Oktoberfest proud.
The thought occurred to me that perhaps one needed a baseball background to perform most of these jobs. Then I thought about the number of front office posts filled by those without baseball skills. Baseball skills aren't always a prerequisite to perform certain front office jobs. The same could be said for journalists.
"Perhaps women simply don't want to work in baseball," I thought. So I began to look around for other signs of diversity. A few African-Americans; a couple of individuals of Asian descent . . . and that was it. The most shocking thing: almost no obvious Latinos.
This was a depressing realization. After all, Latinos made up 27 percent of players on MLB opening day rosters and around 50 percent of minor league players. They've had a strong impact on the game for 40 years, and so one would expect to find them dotted throughout the room.
I tried providing an explanation for this. Perhaps all of the Latino front office personnel were back in their home countries, either coaching or running winter league teams there? Or perhaps they were off scouting those leagues? Or perhaps they are genuinely underrepresented in this room.
Baseball teams are as diverse as ever, with minor leaguers coming from virtually all corners of the world. This makes for a fun, interesting environment. Unique perspectives, and a lot of laughter, are brought to almost every situation. But this room hardly represented diversity.
On the way to Indy, I happened to be watching "Skulls III." It's one of the worst movies ever made (please don't watch it), but it ironically focuses on a female's attempt to become the first woman tapped by Yale's exclusively male secret society. Obviously baseball isn't as discriminatory as this group. The possibility even exists that there is a reason for the situation. Perhaps those from diverse groups either are less qualified or don't want to work in baseball. Or maybe it was just coincidence.
Whatever the reason, I was surrounded by white men, and my wife was happy.


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Past Issues
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View our Centennial issue as a real online magazine!
Due to the highly visual nature of the layouts in this issue, we have created a flippable, zoomable online version of CC: Connecticut College Magazine that can also be downloaded and printed out.
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The School of Music at Western Carolina University will present three performances in the first week of March.
Admission is free and open to everyone.
The WCU Symphony Band will present "Music of Countries and Cultures" at 7:30 p.m. Sunday, March 3, in the John W. Bardo Fine and Performing Arts Center. Billed as a "musical tour of nations," the concert will feature the works of John Barnes Chance, Jay Bocook, Henry Fillmore, Percy Grainger, John Mackey and Frank Ticheli and a variety of music from Asia, Scotland, Ireland, Australia, Egypt, Africa and the Americas. David Starnes, director of athletic bands, and graduate student Emily Talley will conduct.
On Tuesday, March 5, Balaton Chamber Brass will perform at 7:30 p.m. in the recital hall of the Coulter Building. This duo comprises two WCU music faculty members, Dan Cherry on trombone and Amy Cherry on trumpet, who have performed together since 2000. The program will include "Concertino for Trumpet, Trombone and Piano" by Jacques Casterede; "Contrasts in Blue" by Howard Buss; "The Bushwakker Brewpub" by Elizabeth Raum; "Next Exit" by Wes Flinn; and "Czardas" by Vittorio Monti and arranged by Gail Robertson.
On Wednesday, March 6, the School of Music will present solo marimba virtuoso Andy Harnsberger at 7:30 p.m. in the recital hall of the Coulter Building. Harnsberger, a performer and educator, will lead a marimba master class, also free and open to the public, at 2:30 p.m. in the Coulter space. Harnsberger earned his doctoral degree at the Eastman School of Music, is director of percussion studies at Lee University in Cleveland, Tenn., and is active throughout the year as a freelance percussionist and recitalist. His appearance is sponsored by the WCU Visiting Scholars Program and the WCU School of Music.
For more information about any of these events, call the WCU School of Music at 828-227-7242.


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Lena Dunham: Casting Donald Glover on GIRLS Wasn't 'A Reaction to Anyone'
In a recent interview with Vulture, Girls creator and star Lena Dunham shed some light on how she's responded (or not) to critics.
Following last night's episode, in which Hannah breaks up with her Republican boyfriend, Sandy (Donald Glover,) many assumed his casting was in reaction to critics claiming the show was just a bit too white.
"We cast Donald because of a love of his work," she told Vulture. Glover, as well as Dunham, decided to confront the criticism just a bit. "But having such a conscientious person with so many particular opinions on the topic, it seemed only correct that we should play around together on that."
That 'playing around' eventually segued into their exceptionally awkward break up.
"There was a script but we just went HAM on the script; I mean, we went crazy," she said. "The script was the basic arc of that conversation, and the improv was my weird Missy Elliot rap lyric and the moment where Donald goes on his diatribe and he's like, "I'm gonna get a fixed gear bike and I'm gonna date a black guy!" All that stuff. Donald raps a lot about his relationship to being like a hipster black guy and the fact that he's been in like a very white comedy scene and a very white like indie music scene - he has that lyric about being the only black guy at the Sufjan Stevens show - so he had a lot to say on the topic."<
But Dunham wants viewers to know Hannah didn't leave Sandy because of his beliefs - it was mainly because of Hannah.
"Hannah acts like she has a political issue with him, but what she actually has an issue with is him disliking what she does. Because she feels like she should receive universal praise, and the fact that someone's sleeping with her should also mean that they respect her prose style."
Click here to read the original report.
For last night's BWW TV World recap of GIRLS, click here.


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Hazel J. 'Jeannie' Roush
Hazel J. "Jeannie" Roush, 83, of Keosauqua, died Monday, May 26, 2014, at Good Samaritan Society-Van Buren in Keosauqua.
A private family burial of cremains will be at a later date in Harness Cemetery in Mount Sterling.
Memorials to American Heart Association may be mailed to the family at 306 First St., Keosauqua 52565.
Pedrick Funeral Home in Keosauqua is assisting the family.
Ms. Roush was born April 5, 1931, in rural Douds, the daughter of Ray S. and Elsie Clair Barker Roush.
She grew up in the Mount Sterling area and moved to Keosauqua in the 1950s where she worked at Hotel Manning, babysat for several children in the area and was a member of the VFW Auxiliary.
Survivors include one brother, Carl Roush of Keosauqua; and three sisters, Alice Greone of Aannandale, Virginia, Mildred Hutchenson and Francis Roush, both of Missouri.
She was preceded in death by her parents; three brothers, Samuel, Keith and Robert Roush; and three sisters, Beatrice Panting, Janice Judd and Louise Nichols.


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Scene423 Mikhael attacked by rival gang
Next day Arjun has a conference to attend at 9pm and dinner and Karan will also be going to that. At 6pm he gets a call from Billu-Mikhael had gone on some business assignment and rival gang had plans to attack him. Arjun tells Karan to carry on alone and rushes to the spot an isolated building where Billu had mentioned. Billu is waiting for him.
Mikhael scared: Arjunnn, you here?
Arjun: Who told you to come here all alone?
Arjun: Give me that gun and you go from here. Billu is waiting in car below.
Arjun: I will divert their attention by running across. You run in other direction and go to Billu and you both leave OK
Mikhael: But you?
Mikhael: OK
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Arjun sees that now Mikhael has sat in the car with Billu before the rival gang members reached them and drove off in full speed. Arjun thinks great now Mikheal and Billu are safe. But how does he escape.
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Karan waves at him to join him at his table. Arjun joins him at his table.
Karan: What happened, you are late and looking tensed?
Arjun: Nothing Karan
Karan does not believe him and is about to ask him when police arrive.
Karan stops Rajveer path: Excuse me, what nonsense is this?
Rajveer: None of your business
Karan: Anything to do with Arjun is my business.
Rajveer: Who are you his lawyer?
Arjun looks at him with gratitude and thinks: Actually much more than friend, you are my brother
Karan: Do you have arrest warrant, its mandatory?
Rajveer: Not for known criminals like your friend here
Karan; Proof, any proof
Rajveer: That we will get once we interrogate him in police station
Karan: You cannot arrest anyone without proof
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This week, lets take a look at a slightly older book, Babycakes. Another result of my trolling the local library (which has a blissfully extensive lending system linked together over several counties), this book is another that is not currently in my personal collection.
It's a lovely book, with lots of color, glossy pages, and pretty pictures. For all that, some of the fonts chosen are difficult to read, and it's not a comfortable browsing book. It is an exciting book to look at, with lots of intriguing recipes to try. This book has more sidenotes and extensive head notes, which give it more character and interest. It's introductory material on choosing and using ingredients and equipment is also more developed. Chapters follow that cover muffins, biscuits and scones, teacakes, cookies and brownies, cupcakes and frostings, cakes and crumbles, pies and cobblers, and drinks.
Those recipes that I tried were well written, and easy to execute if you've got even a little bit of kitchen experience. The results are typical for vegan/gluten-free. On a personal level, I'd just as soon NOT bother with the vegan part, as I find the results less than ideal. The overt flavor of coconut oil is off-putting in many instances. I didn't even have the option to try out many of the frosting recipes, as I could not locate soy milk powder anywhere locally. The "drinks" chapter, which includes a mere 5 recipes - for lemonade, Babyberry, a vanilla shake, an Arnold Palmer, and hot chocolate - was completely superfluous.
Again, if you're used to gluten-free baking, but not vegan baking, you're going to have to add a string of new ingredients to your pantry. And, as this book bills it's recipes as mostly sugar-free as well, a number of alternative sweeteners.
At this point, I'm going to take a brief moment to be cranky about the "sugar-free" thing. These recipes are NOT "sugar-free" by any chemist's definition. The closest I would grant would be "refined white sugar free". Both agave nectar and evaporated cane juice are still sugars. Somewhat chemically distinct from straight sucrose, but sugars nonetheless and able to stimulate an insulin response. To me, this is more than a little misleading and I'm a bit surprised that the "sugar-free" bit made it on to the cover.
Of the two books, I preferred the Flying Apron Baking Book, but in truth, I own neither and don't have any burning desire to.
Friday, November 25, 2011
Friday Book Review, Nov 25
Posted by Holly at 6:00 AM
2 comments:
Our gluten-free cookbook reviewer had great results with this book and loved the overall visual appeal, as one of her biggest pet peeves are ugly GF cookbooks. Flying Apron is next up!ReplyDelete
I'd agree that a lot of them could use some good design work. :-) Unfortunately, so far I'm finding that a lot of times the "ugly" or plain books are more useful. This one is pretty, but I just find the ingredients used to substitute for butter and eggs a little off-putting. And I REALLY have a problem with calling any of it "sugar-free."ReplyDelete
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ATLANTA, Aug. 18 (UPI) -- A top Republican who promoted an Atlanta fundraiser for likely GOP presidential nominee John McCain stayed away from the event, The Wall Street Journal said.
Ralph Reed, the former head of the Christian Coalition and a high-profile figure in a scandal involving disgraced lobbyist Jack Abramoff, had e-mailed friends in recent weeks touting the Monday night McCain fundraiser. However, Reed was not at the event and McCain did not mention him during his remarks, the newspaper said.
McCain, who participated in a congressional probe of the Abramoff scandal, had come in for criticism for his apparent association with Reed -- who was not charged with any wrongdoing but whose public image was damaged by details of his role in lobbying and fundraising operations conducted by Abramoff and others.
Abramoff is serving a 6-year federal prison term for fraud, and has reportedly been cooperating with investigators looking into corruption involving public officials.
A McCain campaign representative would not say whether the campaign asked Reed to stay away from the fundraiser.
The campaign of likely Democratic president nominee Barack Obama issued a statement saying the McCain campaign "scrambled' to "scratch Ralph Reed from tonight's program."
"The real question isn't why Reed isn't showing up, but why a so-called reformer would invite him at all," the statement said.


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Physician Recruiting About to Get Tougher for Rural Hospitals
When it comes to recruiting physicians, it's like this: Rural hospitals have to work harder, talk to more candidates, and expect more rejections.
Of course, this should come as no surprise to anyone familiar with recruiting clinicians to rural America. And the data backs it up. These concerns are detailed in the 2012 In-House Physician Recruitment Benchmarking report from the Association of Staff Physician Recruiters.
Intelligence Report: Physician Alignment—Integration over Independence
Learn how healthcare leaders are ensuring alignment as the shift from independent to employed physicians accelerates. This original research and analysis, produced with support from MedSynergies, offers key insight from top healthcare executives, including new case studies from Memorial Hermann Sugar Land Hospital, Gadsden Riverview Regional Medical Center, and Vanguard Health Chicago. >>> Download Report
The report suggests that the increased demand for healthcare services, which are expected with the full implementation of the Affordable Care Act, is going to make recruiting doctors even more difficult for rural providers in the coming years.
"There is no indication whatsoever that rural recruiting is going to get any easier," says Shelly Tudor, chair of the ASPR Benchmarking Committee and member-at-large of the ASPR Board of Directors.
"In fact, the report shows that the cost of recruitment is going up, [which will make it] it harder for rural healthcare organizations to compete. A clear correlation exists between the facilities' population size and acceptance rates, with offers from organizations in larger populations much more likely to be accepted than those in smaller populations."


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may be in hammersmith first weekend in nov, anyone know of any campsites (for a small camper van) within range or (if there is such a thing) super cheap accomodation? will need to get in daily, may be able to do it on the tube but driving would be best.
Chat Forum
camping/cheap accomodation for hammersmith?
Camping? Hammersmith?
Can't think of anything nearby, you could park up in Barnes and stay the night, but I'd be a bit worried about doing so. Otherwise Brentford has a couple of new relatively cheap hotel chains, or possibly stay somewhere a bit further out and get either the Picc or District Line into Hammersmith.
Some suggestions
the gypsy camp that was under the westway for years is probably the closest thing Hammersmith has had to a campsite for a long time!
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If it's on Netflix you'll find it with our search engine. Search below to get started.
TV Shows
Besides being a wolf, Aesop is a playwright with his own traveling troupe of stage-actor animal friends in this collection of animated tales for kids. Many of the stories are adapted from classic Aesop's Fables, such as The Tortoise and the Hare.


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Narrative Noun Synonyms
story, tale, chronicle, description, revelation, portrayal, account, report, record, history, recital, statement
The characterizations were poor, but the narrative was fascinating.
storytelling, chronicling, anecdotal
One of her long, narrative poems has been published in a collection.
Technology / Television (TV) / Non-Narrative Television: Televisual texts (e.g., news and sports programs, game shows, some commercials) that present reality to us without using conventional narrative structures. Instead, nonnarrative television relies on e MORE
Entertainment / Literature / Slave Narrative: A narrative, often autobiographical in origin, about a slave's life, perhaps including his original capture, his punishments and daily labor, and his eventual escape to freedom. Examples include Olaud MORE
Entertainment / Literature / Picaresque Narrative: Any narrative (including short stories) that has the same traits as a picaresque novel. See discussion under picaresque novel. MORE
Entertainment / Literature / Captivity Narrative: A narrative, usually autobiographical in origin, concerning colonials or settlers who are captured by Amerindian or aboriginal tribes and live among them for some time before gaining freedom. An examp MORE
Entertainment / Literature / Narrative Narration: Narration is the act of telling a sequence of events, often in chronological order. Alternatively, the term refers to any story, whether in prose or verse, involving events, characters, and what the c MORE
Entertainment / Literature / Frame Narrative: The result of inserting one or more small stories within the body of a larger story that encompasses the smaller ones. Often this term is used interchangeably with both the literary technique and the MORE


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Electron microscopical examination of gas gland cells of the physostome European eel (Anguilla anguilla) and of the physoclist perch (Perca fluviatilis) revealed the presence of significant numbers of lamellar bodies, which are known to be involved in surfactant secretion. In the perch, in which the gas gland is a compact structure and gas gland cells are connected to the swim bladder lumen via small canals, lamellar bodies were also found in flattened cells forming the swim bladder epithelium. Flat epithelial cells are absent in the eel swim bladder, in which the whole epithelium consists of cuboidal gas gland cells. In both species, Western blot analysis using specific antibodies to human surfactant protein A (SP-A) showed a cross-reaction with swim bladder tissue homogenate proteins of ∼65 kDa and in the eel occasionally of ∼120 kDa, probably representing SP-A-like proteins in a dimeric and a tetrameric state. An additional band was observed at ∼45 kDa. Western blots using antibodies to rat SP-D again resulted in a single band at ∼45 kDa in both species, suggesting that there might be a cross-reaction of the antibody to human SP-A with an SP-D-like protein of the swim bladder tissue. To localize the surfactant protein, eel gas gland cells were cultured on permeable supports. Under these conditions, the gas gland cells regain their characteristic polarity. Electron microscopy confirmed the presence of lamellar bodies in cultured cells, and occasionally, exocytotic events were observed. Immunohistochemical staining using an antibody to human SP-A demonstrated the presence of surfactant protein only in luminal membranes and in adjacent lateral membranes. Only occasionally, evidence was found for the presence of surfactant protein in lamellar bodies.
- Anguilla anguilla
- Perca fluviatilis
epithelial cells of air-breathing organs of vertebrates are covered with a thin fluid layer, the hypophase. This hypophase is characterized by the presence of surface active agents (surfactant), which reduce and modify surface tension at the air-liquid interphase (3, 10, 21). Surfactant consists of various lipids and of surfactant proteins. Surfactant proteins may interact with lipid components and may be involved in the formation of tubular myelin, the adsorption of surfactant, and perhaps contribute to immunodefence (10,28). Lungs and also the swim bladder originate as an outgrowth of the foregut, and the presence of surfactant in the swim bladder therefore is not surprising (3, 4). The amount of surfactant found in the swim bladder is even larger than the amount found in a mammalian lung (3). In swim bladder surfactant, however, the fraction of cholesterol and of unsaturated dipalmitoylphospholipids is much higher than in lung surfactant of mammals. This may be due, in part, to the lower temperatures encountered in the swim bladder. It may also contribute to the observation that, in contrast to lung surfactant, swim bladder surfactant mainly acts as an antiglue to facilitate reopening of the bladder after a collapse or partial collapse, and it may prevent edema.
Lung surfactant is produced and secreted by specialized alveolar cells, the type II pneumocytes (12, 14, 21), and in the airways probably by so-called Clara cells (30). It is not quite clear, however, where swim bladder surfactant is produced. In the swim bladder epithelium of rainbow trout, lamellar bodies resembling the ones found in mammalian lung type II cells were found only in nonciliated cells, which apparently are not involved in gas secretion (1). In cod, for example, a physoclistous fish in which the connection between swim bladder and foregut (ductus pneumaticus) is lost during early development, bodies filled with a dark amorphous matrix are present in so-called gas-secreting cells (2), whereas ciliated cells, which, in the trout swim bladder, supposedly are necessary to move the mucouslike material secreted from the lamellar bodies to the pneumatic duct (1), are absent. For larval walleye (Stizostedion vitreum), it has been proposed that the surfactant enters the swim bladder via the common bile duct (13), which means that surfactant may also be produced from other structures and transported into the swim bladder. Furthermore, in compact gas glands, intercellular lumina called "ducts" or "secretory canals" have been described (5,27). It is not known whether these canals contain surfactant as well, and if so, from where this surfactant originates.
The present study therefore was set out to test the hypothesis that various cell types are able to produce swim bladder surfactant by comparing two species with a completely different swim bladder morphology. In the physoclistous perch, like in many other fish, the lining of the swim bladder consists of flattened epithelial cells. Special gas gland cells, which acidify the blood to reduce the effective gas-carrying capacity and to increase gas partial pressure, are lumped together and form several small, compact structures (gas glands) that are located beneath the flat swim bladder epithelium (18, 24). In eels, the ductus pneumaticus persists throughout development (physostomous fish). In this species, the whole swim bladder epithelium is made up of cuboidal gas gland cells, and the covering epithelial cells are missing. If surfactant is produced in the swim bladder tissue, in perch the flattened epithelial cells might be responsible. Because these cells are not present in the eel swim bladder, in this species the gas gland cells may serve a dual function and secret acidic metabolites at the basolateral membranes and surfactant at the luminal membranes. A previous study, in which carbonic anhydrase was localized histochemically (using Hansson's method) in basolateral membranes of gas gland cells of both species, demonstrated that the comparison of these two species appears to be especially useful to understand swim bladder function (29). Unfortunately, the resolution of the histological sections of this study do not allow for the identification of lamellar bodies, for example, so that a more detailed ultrastructural analysis was performed to identify and localize cell components involved in surfactant storage or release. Furthermore, immunologic studies were performed to identify surfactant proteins and to localize these proteins in cell membranes.
Electron microscopy.
Individuals of the European eel Anguilla anguilla(n = 45, body mass 150–450 g) and of perchPerca fluviatilis (n = 8, body mass 10–50 g) were obtained from local fishermen and kept in a freshwater aquarium at 12–15°C for up to 2 mo. Eels were not fed and kept mostly in the dark. Perch were kept at local light regime and fed with tubifex worms every second or third day. The animals were killed by decapitation and subsequently dissected. Samples of the swim bladder epithelium were cut into small pieces and immediately placed into 2.5% glutaraldehyde in 10-mM phosphate buffer (Dulbecco's formula, pH 7.4) for 30 min, washed, and postfixed in cold 2% osmium tetroxide containing 2.5% potassium ferrocyanide for 90 min. The samples were dehydrated through graded acetone series and embedded in Spurr's 15 low-viscosity resin (23). Ultrathin sections were cut with an Ultracut E (Reichert), double stained with uranyl acetate and lead citrate, and examined with an EM902 (Zeiss). For scanning microscopy, the samples were dehydrated after fixation with the use of graded methanol series, critical-point dried with liquid CO2, sputtered with gold, and examined with a Zeiss DSM 150 microscope (Zeiss).
Cell culture.
The preparation of the gas gland cells followed the procedure described previously (17, 19). Gas gland cells were seeded onto Anodisc 13 membranes (Whatman), cultured until they reached confluence, and then transferred into chambers that allowed us to perfuse the apical and basal side of the permeable support with different media. The basal side was perfused with culture medium, DMEM F12 (Gibco), supplemented with 10 μmol/ml alanine-glutamine, 0.5% eel serum, 0.1% BSA, 1 μg/ml gentamicin, 1 μg/ml kanamycin, whereas the apical side was perfused with pure buffer solution consisting of (in mM) 140 NaCl; 5.4 KCl; 1.0 MgCl2; 10 HEPES; and 0.5 EGTA.
SDS-PAGE and Western blot analysis.
Protein of a swim bladder homogenate was separated by SDS-PAGE with the use of the NuPage buffer system. Electrophoresis was performed with Power Ease 500, X-Cell II using NuPage 10% Bis Tris gels (all from Novex). SDS-PAGE was done under reducing conditions (DTT, 125 μM).
The electrophoretic transfer of proteins to a nitrocellulose membrane was performed with the use of Power Ease 500 (Novex). The transfer was conducted for 1 h at a constant voltage of 25 V (160 mA). The nitrocellulose membranes were placed into a sealed bag containing 0.2% I-Block (casein-based blocking agent; Tropix) or 5% milk powder and 0.1% Tween 20 (Sigma) in 10-mM phosphate buffer and gently agitated for 1 h at room temperature. After the washing, the membranes were incubated overnight at 4°C with the rabbit anti-human surfactant protein A (SP-A) antibody 1:5,000 in buffer containing 3% milk powder. The membranes were then washed and incubated for 1 h with Sigma A 1949 monoclonal rabbit IgG 1:10,000 (conjugated with peroxidase) in 3% milk powder at room temperature. Visualization was done by enhanced chemiluminescence (Amersham Life Science).
Western blot analysis to test for the presence of SP-D-like proteins in swim bladder homogenate was performed basically according to the procedure described for SP-A. SDS-PAGE was again done under reducing conditions, with the use of MOPS buffers and a 10% Bis Tris gel. After blocking, the membrane was incubated with rabbit anti-rat SP-D antibody (1:250).
Cells were fixed in 4% paraformaldehyde in 10-mM phosphate buffer (pH 7.4) for 1 h, washed, blocked for 1 h with 0.2% I-Block (Tropix) and 0.2% Triton X-100 (Sigma) in 10-mM phosphate buffer, and incubated 1:100 with the rabbit anti-human SP-A antibody in blocking buffer overnight at 4°C. After the washing, the samples were incubated with the swine anti-rabbit IgG TRITC-conjugated antibody (Dako), diluted 1:100 in blocking buffer, and embedded in Vectashield (Vector Laboratories).
Live-cell staining was performed with 50 nM LysoTracker Green (Molecular Probes) in 10-mM phosphate buffer containing 10 mM glucose for 1 h. Fixation of the cells after live-cell staining was performed with 4% paraformaldehyde and 0.5% glutaraldehyde. Acetone was used for permeabilization instead of Triton X-100. Analysis was performed with the use of a laser-scanning microscope (Zeiss, LSM 510).
Data analysis.
Data obtained with the laser-scanning microscope were processed on a O2 work station (Silicon graphics) with the use of appropriate software packages (Imaris, 2.6.8) from Bitplane (Bitplane AG). For contrast enhancement and deconvolution, the software package "Huygens, 2.0" (Scientific Volume Imaging BV) was used before three-dimensional visualization with the Isosurface module of Imaris 2.6.8.
Gas gland cells of the European eel form a monolayer spread over the secretory part of the swim bladder epithelium (Fig.1 A). Spread over the whole cell we found small lamellar bodies, but most of them are localized in the apical region. In contrast to the eel, the inner layer of the swim bladder of the physoclist perch includes two types of cells, the gas gland cells, lumped together to several small but multilayered glands, and flattened squamous epithelial cells (Fig.1 B). Sometimes a canal can be seen within the gas gland cells. Near these canals small lamellar bodies are present within the cytoplasma of gas gland cells. A close-up of such a canal revealed the presence of tubular myelin in the lumen of the canal (Fig.1 C). The second cell type forms the lining of the swim bladder lumen. These cells are flattened cells and form a monolayered epithelium between gas gland cells and the lumen. Small microvilli characterize the cells at their apical side. These epithelial cells are also characterized by the presence of a large number of lamellar bodies (Fig. 1 B).
A scanning electron micrograph of the epithelial surface of the swim bladder wall in a region where no gas gland cells are found shows the classical picture of an epithelial lining (Fig.2 A). A scanning electron micrograph of a region where gas gland cells are located, however, reveals the presence of pores with a diameter of ∼5 μm (Fig.2 B). Occasionally, electron-dense material is observed within the lumen of the pore opening. The surface of the epithelial cells is characterized by the presence of microvilli. These electron microscopical observations are summarized to a schematic drawing of eel gas gland cells (Fig.3 A) and of the perch gas gland (Fig. 3 B).
The presence of surfactant in swim bladder cells was analyzed by Western blot analysis using specific antibodies directed against SP-A and -D. The anti-human SP-A antibody showed a cross-reactivity with an eel swim bladder epithelium protein of ∼65 kDa (n = 6 animals), probably representing the SP-A dimer (Fig.4 A). In four experiments, the antibody also cross-reacted at ∼120 kDa, which could represent the SP-A tetramer, and a band was observed at ∼45 kDa. Additional Western blots using a rabbit anti-rat SP-D antibody (n = 5 animals) again resulted in a band at ∼45 kDa. A typical result is shown in Fig. 4 A.
Figure 4 B shows the typical results of the Western blot analysis performed with swim bladder tissue of the perch (in total, 5 animals were tested). With the use of SP-A antibodies, we found a band at ∼64 kDa, which could represent the dimer of the SP-A. Again, there was some cross-reactivity at 45 kDa. Additional Western blots using rabbit anti-rat SP-D antibody (n = 5) again resulted in a band at ∼45 kDa. A typical result is shown in Fig. 4 B.
A localization of surfactant protein was attempted with the use of cultured eel gas gland cells. Gas gland cells of the European eel cultured on permeable supports in a superfusion chamber show the typical polarity as found in vivo. The cells are of cubical shape and show lateral foldings of the membrane and a basal labyrinth. Cultured gas gland cells show a Golgi apparatus, long and slender mitochondria, and a large number of lamellar bodies (Fig.5 A). In some sections, we observed that these lamellar bodies undergo exocytosis (Fig.5 B).
Subsequent immunohistochemical studies (using primary cultures of 8 individual eels) also demonstrated the presence of SP-A in cultured gas gland cells of the eel, and the distribution of SP-A was highly polar. Fluorescence was only observed near the apical and lateral membranes close to the apical side, but not in basal membranes (Fig.6). In addition, we also incubated the cells with LysoTracker Green to stain acidic vesicles, for instance lamellar bodies. Live-cell staining with LysoTracker Green showed a large number of acidic vesicles spread over the whole cell. Colocalization of LysoTracker Green and SP-A only occasionally revealed the presence of SP-A in lamellar bodies located near the cell membrane.
Figure 7 shows a three-dimensional reconstruction of a cell obtained after deconvolution of the data. SP-A (red) is only present on the apical side of the cultured cell; there is no SP-A on the basal side. Acidic vesicles (green) are more concentrated on the apical side, but occasionally they are also found in the basal part of the cell.
Although the presence of surfactant in the swim bladder lumen is well established, the present study demonstrates that surfactant is also present in the secretory canals of compact gas glands and is produced in two different cell types in swim bladder tissue, namely in flattened epithelial cells, if present, and in gas gland cells. Furthermore, eel gas gland cells cultured under appropriate conditions retain the capacity to produce and secrete surfactant at their luminal membranes. In mammals, type II pneumocytes are responsible for the production of surfactant, and mammalian lung type II cells in appropriate culture conditions also produce surfactant similar to the in vivo situation (6, 7, 12).
Within recent years, surfactant has been found in all air-breathing structures of the vertebrates, and an analysis of surfactant proteins revealed that the molecular weight of these proteins varies among species and even within a species, but nevertheless, these proteins are highly conserved (15, 25). With the use of antibodies to human SP-A and -B, the presence of SP-A and SP-B-like proteins in lung epithelial cells of the Australian lungfish (Neoceratodus forsteri) was demonstrated (20), andNeoceratodus is the most primitive member of the Dipnoi, which evolved more than 300 million years ago. Similarly, presence of SP-A-like proteins in air-breathing organs of the African lungfish (Protopterus senegalenses), another species of Dipnoan fish, and in air-breathing organs of other Acanthopterygian fishes (which include the teleosts) has been confirmed with the use of antibodies to mouse SP-A (25). Teleosts evolved much later than the Dipnoan fishes in the Triassic period (9), and the teleost swim bladder may be regarded as a specialization of a primitive air-breathing organ of the Acanthopterygian fishes (8, 9), or it may originally have been an organ with hydrostatic function (11). The teleost swim bladder primarily functions as a buoyancy organ (18), nevertheless, with a probe designed on the basis of a mouse cDNA sequence, mRNA of SP-A-like proteins has been identified in goldfish swim bladder (25). With the use of antibodies to mammalian SP-A, SP-A-like proteins have also been detected in the intestine and swim bladder of carp (22) and in the swim bladder of perch and eel (present study). This clearly confirms the conservative nature of the surfactant system and underlines the importance of surfactant for swim bladder function.
Although in mammalian alveoli, surfactant is produced by specialized epithelial cells, in the perch swim bladder, epithelial cells as well as gas gland cells produce and secrete surfactant. In terms of evolution, this could mean that, initially, epithelial cells were capable of producing surfactant, and gas gland cells are specialized epithelial cells that retained this capability and, in addition, specialized for the production of acidic metabolites. In the eel, the whole epithelium differentiates into gas gland cells, which now serve a dual function. They produce acidic metabolites, released at the basolateral membranes, as well as surfactant, released at apical membranes.
In species with a compact gas gland, located below a layer of flattened epithelial cells, the gas gland cells do not project into the swim bladder lumen. Compared with the eel swim bladder, this arrangement increases the distance between blood vessels and swim bladder lumen, which is crucial for the diffusion of gas into the swim bladder. Nevertheless, the canals in the perch gas gland cells apparently establish direct contact to the lumen and thus significantly reduce the diffusion distance between blood vessels and gas phase. This argument of course is only valuable if these canals remain gas filled and do not collect fluid. Fluid-filled structures typically can be identified by the presence of some kind of precipitation in electron microscopical studies, but none of our pictures provided any evidence for the existence of fluid-filled canals. Scanning electron micrographs demonstrate that these canals open into the swim bladder and that they contain lamellar or tubular material, which most likely is surfactant. The lamellar bodies found near the membranes lining these canals indicate that this surfactant is produced from gas gland cells. The surfactant probably is necessary to prevent a collapse of the canals during volume changes of the swim bladder.
Although the surfactant lipids are released into the swim bladder by exocytosis of lamellar bodies, the situation is less clear for the surfactant proteins. Surfactant proteins have been detected in lamellar bodies, but the secretion of hydrophilic SP-A and of hydrophobic SP-B and SP-C apparently can be regulated in a different way (16,26). In the air-breathing organ of Neoceratodus, immunogold staining revealed the presence of SP-A and of SP-B-like protein in lamellar bodies and in the cytoplasma, but in lamellar bodies the signal was not very pronounced (20). In our study, SP-A occasionally was detected in acidic vesicles of eel gas gland cells. For rat type II cells, it was estimated 7–8% of total SP-A appears to be associated to lamellar bodies (16). Thus at least part of the SP-A is secreted with lamellar bodies.
Rabbit anti-human SP-A antibody was a gift of Dr. M. Post, Department of Pediatrics, Hospital for Sick Children Research Institute, University of Toronto, Ontario, Canada. Rabbit anti-rat SP-D antibody (1:250) was obtained from Dr. G. Putz, Institution for Anesthesia, Univ. of Innsbruck, Austria.
The study was financially supported by the Fonds zur Förderung der wissenschaftlichen Forschung (FWF, P11837-BIO).
Address for reprint requests and other correspondence: B. Pelster, Institut für Zoologie und Limnologie, Universität Innsbruck, A-6020 Innsbruck, Austria (E-mail:Bernd.Pelster{at}uibk.ac.at).
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2000 the American Physiological Society


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The Fairy | 2012
Dom works the night shift in a small hotel. Fiona checks in, claiming to be a fairy and offering him three wishes. Dom falls in love with her, but after two wishes come true, she disappears.
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Courage Mon Amour Films
Social misfit Dom is relegated to working the night shift in a small hotel near the industrial sea port of Le Havre. One night, a woman named Fiona shows up with no luggage and no shoes. She reveals to Dom she is a fairy and grants him three wishes. After making two of his wishes come true, she mysteriously disappears. Having fallen in love with Fiona, Dom searches for her high and low, encountering many obstacles along the way.


text: Jun_The_Gamer 151 Report post Posted October 30, 2013 How do I make , for example a Title screen and when an option is selected, for example "Play game", the screen switches to the gameplay screen? Do I have to clear the screen and then enter the game loop? Do I need to make Individual loops inside the main gameoop for different screens, if yes, can you provide a quick example? I still don't understand the screen states. 0 Share this post Link to post Share on other sites


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Free Trade Agreements as Protectionist Devices: Rules of Origin
In this paper it is argued that there is an important protectionist bias inherent in free trade agreements which is not present in custom unions. In any customs union or free trade agreement, one of the critical issues concerns "rules of origin." In a free trade agreement rules of origin have an important function because, without one, each imported commodity would enter through the country with the lowest tariff on each commodity. The criterion for duty-free treatment is important in determining the economic effects of the rule of origin. It is shown that rules of origin in fact extend the protection accorded by each country to producers in other free trade agreement member countries. As such, rules of origin can constitute a source of bias toward economic inefficiency in free trade agreements in a way they cannot do with customs unions.
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|Date of creation:
|Apr 1993
|Publication status:
|Published as "Free Trade Agreements Versus Customs Unions", Journal of Development Economics, Vol. 54, no. 1 (October 1997): 169-187.
|Contact details of provider:
| Postal: National Bureau of Economic Research, 1050 Massachusetts Avenue Cambridge, MA 02138, U.S.A.
Phone: 617-868-3900
Web page: http://www.nber.org
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- Lawrence H. Summers, 1991. "Regionalism and the world trading system," Proceedings - Economic Policy Symposium - Jackson Hole, Federal Reserve Bank of Kansas City, pages 295-301.
- Hoekman, Bernard M. & Leidy, Michael P., 1992. "Cascading contingent protection," European Economic Review, Elsevier, vol. 36(4), pages 883-892, May.
- Kemp, Murray C. & Wan, Henry Jr., 1976. "An elementary proposition concerning the formation of customs unions," Journal of International Economics, Elsevier, vol. 6(1), pages 95-97, February.
- Gene M. Grossman, 1981. "The Theory of Domestic Content Protection and Content Preference," The Quarterly Journal of Economics, Oxford University Press, vol. 96(4), pages 583-603.
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A Borehamwood brass band will visit the borough's twin town in Germany for the first time in 14 years.
Borehamwood Brass, which has around 25 members, will play at a wine festival in Offenburg after they were invited by the city's twin town association.
What used to be a long-standing tradition, which saw a similar German band and Borehamwood Brass make alternate visits, stopped when the German band split up in 2002.
Andrew Grady, who plays the cornet in the band, as well as being vice chair of the Borehamwood Twin Town Association (BETTA), has been trying to restore links between the two areas.
The 48-year-old said: "I heard about the wine festival so thought that might be the perfect opportunity for the band to go back.
"I am very excited about it and very pleased that we have been able to begin rebuilding some of the links that were lost when the German band split up."
The band's visits first started in the 1980s, and the last time Borehamwood Brass went to Offenburg was in 1998. But when the German band was disbanded contact was lost.
Mr Grady added: "It was a shame, because a new band was formed but they weren't interested in continuing the tradition."
Mr Grady, who grew up in East Yorkshire but now lives in Burghley Avenue, Borehamwood, met his German wife, Erika, on one of the bands trips with Offenburg in the late 90s.
The group will be making the trip to Offenburg to play their wine festival in September.


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Homebuyer Education Classes Offered in Rockport
MaineStream Finance, a subsidiary of Penquis, is offering hoMEworks approved homebuyer education classes at Five Town CSD Adult & Community Education. These classes will help prospective homeowners determine if renting or owning a home is right for them. It covers additional topics such as: planning for home ownership, types of financing available, home selection, and responsibilities and servicing for both the loan and property.
Class participants who attend all classes receive a homebuyer education certificate, recognized by Maine State Housing Authority and Rural Development
Starting Date: January 29th through February 26th
Time: 5:30 pm - 8:00 pm
Length: 4 weeks
Price: $40.00
Located at 25 Keelson Drive, Rockport.
To register contact email@example.com or 236-7800 ext 274.


text: On Sat, 6 Jul 2002 00:41:41, Lil wrote: we have other members who live outside the US and don't celebrate 4 July... Like Mauricio for instance. Yoohoo, Mauricio! Where are you? ------------------------------------------------------------------------------------------------------------------------------- I'm here, Lil...I'm here. I have just been watching how you girls mourn this silence. I'ts really incredible how something that doesn't exist can weigh upon you. Silence can be, in certain instances, a strong depressive agent. Your observation of the members that do not celebrate United States' main holiday is quite true. On Thursday what was more impacting for us in my country, was the terrible killing in Los Angeles' Airport. Indeed, silence can regenerate but also can overcharge. By the way, Lil, I'm glad to see you're active again in the list and also glad to have you remember me. Cheer up, that life can also be very beautiful in spite of any shortcoming! Mauricio --------------------------------- Do You Yahoo!? New! SBC Yahoo! Dial - 1st Month Free & unlimited access To unsub or change your email settings: http://www.freelists.org/webpage/pctechtalk To access our Archives: http://groups.yahoo.com/group/PCTechTalk/messages/ http://www.freelists.org/archives/pctechtalk/


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Appearance: bright green, silky fine grain
Aroma when Dry: sweet, velvety, butter texture
After water is first poured: creamy, sweet, buttery
Tea liquor:
At beginning of steep: bright spring green, (after shaking) lighter froth highlights
At end of steep: color deepens a shade
Staple? Type yes, may reorder brand
Preferred time of day: any
At first: Rich, bodied, somewhat vegital, chewy, hints of grass, brothy, no bitter notes
As it cools ? gets sweeter, milkier
Additives used (milk, honey, sugar etc)? No
Lingers? Yes, with a velvety brothy, sweet (eastern) note
Good cooled


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Presently, all eyes are on this dusky beauty who will be seen romancing our very own Greek God —Hrithik Roshan in Mohenjo Daro.
What's more, this former Miss India contestant is also touted as the next-big-thing.
The buzz around this debutant of Bollywood, who is already a sensation down south is so much, that we were forced to snoop around a bit and what we came up with is sure to catch your fancy.
Here' are what we dug out about B-town's new darling — Pooja Hegde.
1. When she was a child, Pooja wanted to become a postman as she thought that it was a cool job. At some point, she even contemplated becoming a lawyer. In fact, Pooja never thought she would become an actor as she considered herself to an ugly duckling back in school and was a complete tomboy with short hair.
2. Pooja is full of wanderlust and it is one of the reasons why she enjoys her profession so much. "I love travelling and I see a new place every year. Luckily, my job helps me do that very easily," she said in an interview.
3. She hates it when someone doesn't pronounce her last name correctly.
4. Though Pooja is born and brought up in Mumbai, she is quite attached to her hometown Udupi.
5. She might flaunt a size zero figure, however, Pooja is a total foodie and there is nothing that can keep her away from food. Recently, when she flew back to Mumbai from her trip to Hyderabad, she carried 5 kg haleem (a stew made of wheat, barley, meat, lentils and spices) with her.
6. American actor Joshua David Duhamel, who has appeared in the popular Transformer series is her celebrity crush and Pooja hopes that someday she will get to share screen space with him.
7. She is addicted to TV shows and most of her spare time is spent watching English TV shows like Grey's Anatomy, Modern Family, House MD and a few others.
8. Pooja is a voracious reader and she also loves dancing, singing and following a few sports like tennis.
9. She comes from a middle-class South Indian family and speaks Tulu at home. In fact, she started her acting career with the Tamil film – Mugamoodi and is quite a sensation down south.
10. She is an ardent animal and nature lover.
Image credits: dailyupdates.in and Instagram


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Website updated pages 23/3/2012
Expand Messages
AATTC Website www.aattc.org.au
Sydney Buses Ferries and Trains from Adrian Dessanti
References to Star City Casino have been changed The Star Casino – it is suspected the timetable list for the casino is well out of date.
Light Rail/Mono Rail – Amended to show that they are now owned by the NSW Government who plan to demolish the monorail. They will continue to be operated by Veolia.
New South Wales timetables.
Countrylink – correcting the dates for the North Western and Southern timetables which were shown as 24 October 2011 – they should be 23rd October. The Northern timetable dated 23rd October is available on the Countrylink website but has not been seen in paper form.
Lourie Smit
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Retail Fixture-Carpet Reset
Job ID: 3045-118529-2
Login or Create a Profile to apply for this job.
- Location: SOUTH SETAUKET, NY 11720-2007
- Project Type:Heavy Merchandising
- Schedule Type:Specific
- Start Time:09:00PM
- Estimated Hours per Day:10
- # of Workers Needed:1
- Pay Type:Hourly
- Dates: 08/14/13 - 08/14/13
Project Description
- This work involves highly physical activities and lifting up to 75 lbs.
- You will be working with beams, tearing out old displays and fixtures, installing new ones or moving heavy store fixtures.
- You will be setting product per planogram, tagging and installing signs and POP materials if needed
- Use of power tools and a cordless drill may be required
Application Instructions
Recommended Skills for the Ideal Candidate
- Ability to stand 8+ hours on concrete floors
- English
- Consistently lift 50 lbs.
- Location: SOUTH SETAUKET NY , 11720-2007
- Link to map: View map of General Location


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Flare Gun
A single shot, breech loaded, 12 guage firearm designed for the launching of flares. It is typically used for signalling or distress signalling at sea or from ground to aircraft. It is not designed to function as a weapon and would be ineffective under such circumstances. Flare Guns have a single action trigger mechanism, hammer action, center fire pin. Modern varieties are frequently made out of brightly-colored, durable plastic.
Damage: D6 x 5 (15)
Range: 3 / 10 / 20 / 60 / 120
Encumberance Value: 1/1
- Flare guns take a -2 penalty to attack as they are not designed or balanced for combat in any way.


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Artist description:
No description entered.
Flash Draw Created May 04, 2007 470 x 338px Unless noted Copyright 2007 echo32gamer.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
amazing to watch this come together - so cool!
hahaha love this this game!! gave you a 9 because it such a little but its cool!
ah its him again :D:D
Amazing drawing 10/10 keep it up ^-^


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The First Indian Film Festival Of London
Not to be confused with last month's London Indian Film Festival, this event tends towards more socio-political matters – opening film Peepli Live (pictured), for example, wryly observes the media's treatment of a suicidal farmer. There's also a focus on director Vidhu Vinod Chopra, who has worked at both ends of the spectrum. His 1978 doc An Encounter With Faces looked at Bombay street kids long before Slumdog Millionaire, but last year he produced buddy-romcom 3 Idiots, the top grossing Bollywood movie ever. Issues covered elsewhere include the western adoption of Indian babies, the Bhutto dynasty, and, in Dunno Y … Na Jaane Kyun, for just about the first time, a gay relationship.
Riverside Studios, W6, Wed to 29 Aug, iffl.co.uk
The DIY Youth Film Festival, London
James Cameron's Avatar is being rereleased next week, just in case anyone in this universe or any other has failed to see it, but rather than going again, why not make your own? It might not look exactly the same, but through these Avatar-themed workshops, eight to 12-year-olds can learn to become the next kings and queens of the world in four easy steps. Each morning there are workshops to create a "future human" character, develop a story using Comic Life software, animate it against a green screen and create a soundscape, then see a screening of it in the afternoon. Now, each session is a steep £15, but parents can console themselves by thinking of the galactic box office rewards their fledgling auteurs are sure to reap in the future.
BFI Southbank, SE1, Tue to Fri, bfi.org.uk
Frightfest, London
More blood for your bucks as the leading horror and fantasy festival brings fresh meat to town, although the hardcore could get more than they bargained for with the controversial A Serbian Film – a bar-lowering shocker that takes the term "torture porn" all too literally. You're better off with Gareth Edwards's genre-melding sci-fi romance Monsters, already being dubbed "the new District 9", or Evil Dead-style Aussie horror Damned By Dawn. And there are premieres galore – the remade I Spit On Your Grave, Hatchet II, Kiwi splatterfest Wound (pictured), Korea's Bedevilled – and a healthy contingent of British horror. But the highlight must be the presence of gore god Tobe "Texas Chainsaw Massacre" Hooper, who's bringing his 1969 debut feature, Eggshells, which he describes as a mix of Andy Warhol's Trash and, believe it or not, Disney's Fantasia.
Empire Leicester Square, WC2, Thu to 31 Aug, visit frightfest.co.uk
Star Trek Weekender, London
Dare you boldly go where no fan has gone before? For those who wish they actually lived in a galaxy of warp drives, phasers, Vulcans and tribbles (if you don't know what a tribble is, you need to stay in more), here's the closest you'll get: all 11 Star Trek movies, back to back. Think of it as a crash course in Klingon. You'll launch on Friday evening with a double-bill of Star Trek: The Motion Picture and The Wrath Of Khan, and by Sunday evening, two days and 19 solid hours of Trekdom later, you'll be primed for JJ Abrams's lively reboot.
Prince Charles Cinema, WC2, Fri to 29 Aug, princecharlescinema.com


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What is a P3?
P3 Ordinance & Proposed Contracts
Certificate of Qualifications
Game Changing Agreements Approved for Development and Management of Gary/Chicago International Airport, City of Gary, Northwest Indiana
Game Changing Agreements Proposed for Development and Management of Gary/Chicago International Airport.
Press Release - Request for Proposals sought by City of Gary and Airport Authority for Public-Private Partnership to Invest in Airport and Surrounding Area
A P3 is a public-private partnership (contractual agreements) formed between a public agency and a private sector entity to allow for greater private sector participation in the delivery and financing of transportation projects.
A P3 agreement the between the Airport Authority, the City of Gary and private management company will provide:
Potential Economic Impact
The best strategic investments in the airport will:
The Northwest Indiana Regional Development Authority estimates the economic impact of a revitalized Gary/Chicago International Airport would bring:
Please leave a comment. The Gary/Chicago International Airport Authority welcomes your feedback.


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Feb 05, 2013 Phil Blackwell Uncategorized
For a long time, speculation had centered on whether Tyler Rouse, Baldwinsville's record-setting senior tailback, would make his way to an elite college football program.
That speculation ended Tuesday when it was learned that Rouse would head to Boston College, signing his letter of intent a day later in a ceremony at the Baker High School library alongside Emma Firenze, who made her signing at Syracuse University for soccer official.
In going to SU, Firenze will join her older sister, Jackie, who just completed her freshman season for the Orange. Emma and Jackie were teammates on B'ville teams that won Section III Class AA titles in both 2008 and 2010.
Not until last weekend did Boston College make a formal offer. Without it, said Bees head coach Carl Sanfilippo, Rouse was likely headed for a prep school for 2013-14 until a program similar to BC's stature would reach out to him.
Just 5-foot-8 and 200 pounds, Rouse emerged as a star in 2010, his sophomore year, where he led B'ville to its second consecutive Section III Class AA title and a berth in the state semifinals.
After a strong junior campaign, Rouse, in 2012, topped himself on an individual basis, carrying the Bees to the sectional finals as he got the ball 333 times for 2,977 yards, amassing 45 touchdowns.
That earned Rouse a stream of accolades, none bigger than the Gatorade New York State Player of the Year award, the first Section III player to earn that honor since Onondaga's Latavius Murray (who went on to a fine college career at Central Florida) in 2007.
In going to BC, Rouse will join up with the Eagles' new head coach, Steve Addazio, who actively recruited Rouse while he was at his previous coaching position at Temple.
Just as intriguing to local football fans is the fact that Rouse will be part of the Atlantic Coast Conference, just as Syracuse University joins the ACC.
Both the Eagles and Orange are in that league's Atlantic division and will meet in the 2013 regular season at the Carrier Dome at a date and time yet to be determined.
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I had never been married before and had no idea what I was doing. I researched on the internet and found the newly renovated Loose Mansion. We did our rehersal dinner, wedding, and reception here which made it very easy for the wedding party and guests. The staff was wonderful through every step of the process; from the vender lists to the ideas they had. Everything was customized exactly the way we wanted things and the chef even provided a wonderful meal that was within our budget as well. For the bar we did have to bring our own liquor but everything else was provided and the parking was even free. I think what I enjoyed the most was the elegant pictures that were made on the property; from the pictures on the terrace to the relaxed pictures of the guests in front of the fireplace, there was not one room of the mansion that was not over the top beautiful. I have a exquisite wedding albulm for my lifetime memories. I would reccommend Loose Mansion and their staff to anyone.
We were married last year at the Loose Mansion in Kansas City. It was an amazing experience. I have always wanted a wedding reception that wasn't in a cookie cutter chain hotel. The Loose Mansion provided the perfect venue. The building is a historic landmark so there were many photo settings that unique. The in house cooking staff was amazing. We had several guests with special dietary needs and they were all perfectly met. I strongly recommend going to a tasting party in order to help narrow down a menu from the many available options. The smoked meats are a house specialty. The mansion has a few accommodations on the wedding grounds. This was a must for us. We had several grandparents and even a great grandmother in attendance. The use of the carriage house as a staging and rest area made coming to the wedding possible for our loved, elderly guests. The staff at the Loose Mansion is very attentive to detail. I never had to repeat myself as they took notes and made sure to summarize details with me at the end of each meeting to make sure we were understood. Another plus, is that all furnishings are available directly from the mansion. Since I travel a lot for business, this really simplified things. I did not have to find and rely on numerous independent vendors. The Loose Mansion is next to Loose Park, which makes having an outdoor ceremony very easy. We did not have to provide transportation for our guests to the reception. I would strongly recommend the Loose Mansion to the most discerning wedding clientele.
The venue was just absolutely beautiful, I could not have wanted a more stunning place to hold the 50th anniversary of my parents. The mansion is elegant, eclectic and unique; around every corner was more and more scenery that pleases the eye. The staff were wonderful and helpful, they were always on hand and ready to help me. I would highly recommend this setting.
I had my wedding at Loose Mansion in May 2011. It was such a beautiful and different venue site. My guests couldn't stop commenting on the rooms and decor all night. The staff was so helpful throughout the entire process. It was great not to have to worry about set up and clean up! I want to get married again just so I can go back to Loose Mansion!
When I began wedding planning my biggest concern was finding the perfect venue. I searched and searched and the moment I stepped inside the door at Loose Mansion I knew I had found the place. The Loose Mansion is inviting, beautiful and elegant. From the very first meeting to the day of the event, Barb and her team ensured my fiance and I felt welcomed and comfortable every step of the way. From recommending vendors to hosting a food tasting (the Loose Mansion chef is amazing) to offering the use of their decor collection (they have beautiful linens, dinnerware, center pieces, candelabras, etc.) Loose made every decision so easy! Loose also scheduled countless meetings, answered multiple phone calls and emails and even welcomed us into the mansion to roam around when we didn't have an appointment! The team helped us realize our ideas and visions for the day and then exceeding our expectations. They truly are a full-service venue. September 5 was the greatest day of our lives thanks to Loose! And our friends and family agree! Thank you Barb, Amy, Allison and the rest of the Loose Mansion staff!


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- Ferrari
Alonso better than Schumacher - Massa
Felipe Massa says Fernando Alonso is a stronger driver than Michael Schumacher having raced with both at Ferrari.
Massa will leave Ferrari at the end of the year after eight seasons with the team, during which he was Schumacher's team-mate for one season and Alonso's team-mate for four. Asked during an interview for the official Ferrari website which of the two drivers was stronger, Massa was clear in his answer.
"Fernando," Massa said. "Schumacher was as quick, but in terms of intelligence, Alonso is better because he manages to put everything together perfectly."
Reflecting on his best moment as a Ferrari driver, Massa said winning his home race stood out.
"Definitely 2008 when I came that close to the world title, with many wins and poles. But the day that will always stay with me was the one of my first win in Brazil (2006.) For a Brazilian to win at home is like taking the championship. Remember Senna? When he won in Interlagos he was happier than when he won the championship! I learned to race in Interlagos, I grew up there: to win there in a Ferrari wearing a green and yellow suit was the best moment of my life."
Asked if he felt like a world champion in 2008, Massa added: "100% yes. I deserved the title, taking into account the season and everything that happened…"


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Biogen Idec Submits Application to FDA for First Long-Lasting Factor VIII Therapy for Hemophilia A
Biogen Idec announced today that the company has submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for the marketing approval of recombinant factor VIII Fc fusion protein (rFVIIIFc) for the treatment of hemophilia A. Recombinant FVIIIFc is the first hemophilia A product candidate in a new class of long-lasting clotting factor therapies being developed with the goal of reducing the burden of treatment for this condition. If approved, rFVIIIFc will be the first major advance in hemophilia A treatment in more than two decades. The regulatory submission was based on results from A-LONG, the largest registrational phase 3 clinical study in hemophilia A to date.
"This regulatory submission marks another significant step toward our goal of transforming the care of hemophilia for patients, families and caregivers," said Glenn Pierce, M.D., Ph.D., senior vice president of Global Medical Affairs and chief medical officer of Biogen Idec's hemophilia therapeutic area. "In our phase 3 study, patients treated with rFVIIIFc were able to inject rFVIIIFc once-weekly to twice-weekly, which creates the potential for those currently on prophylactic treatment to reduce injections by 50 to 100 per year. Moreover, patients currently treating bleeding episodes could potentially dose prophylactically once per week and maintain significant protection from bleeding with about the same total number of injections each year they use to treat bleeding episodes today."
Typically, prophylaxis in hemophilia A requires injections three times per week or every other day to maintain a sufficient circulating level of clotting factor to provide protection from bleeding. Without prophylactic treatment, people with hemophilia A remain at risk of bleeding episodes that can cause irreversible joint damage and life threatening hemorrhages.
On March 4, 2013 Biogen Idec announced the FDA accepted for review the company's BLA for its factor IX candidate, rFIXFc, for use in patients with hemophilia B.


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I live in South Florida and the company I work for has seats for sporting events in Miami. I have gone to the past 3 Orange Bowls so I've had these tickets for awhile so I didnt' get this to see JH but its a bonus.
My plan tonight is to dress up like Bon Jovi and keep John Elway away from JH. During the half time show dress up as a Wolverine and attack any 49er personal at the game with Joe Montana's shapeup sneakers.
All kidding a side I'm going to rock my Block M hat at the game and have a good time. I thought about bringing my Block M flag into the game but that might be a little too much and not very Michigan man like.
Either way I'm pumped to see a good bowl matchup .
Go Blue!