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Starring Rob Kingwill
"I really don't know what this trick should be called, but I first did it by accident at the Breck pipe and have been able to do it ever since. Some people think it should be called a 'Kinger Flip.' Some people have said it's a frontside McTwist. Todd Richards called it a 'Suicide Flip,' and I like to call it a 'Sato Flip.' Sato means sugar in Japanese, but I don't really care what it ends up being called, all I know is that it isn't a Crippler."
1. Drop in fast.
2. Ride up the transition like you're going to do a frontside 540.
3. Pop in the air and grab frontside, then throw your head, shoulders, and hips down the hill.
4. Lean forward and look under your heelside edge. (Don't look straight back like a Crippler.)
5. Float around upside down and tweak.
6. Use the force to figure out when to put your feet down because you can't see the landing until you're there.
7. Stomp that shit and celebrate by doing a huge method on the next wall.
Robbie Kingwill is a native of Jackson, Wyoming but spends the majority of his year traveling and competing. He is a pipe digger at Mt. Hood during the summer and proudly represents Nike. Air Kinger snowboard boot?


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Bogusevic in the lineup after pitching
Bogusevic in the lineup after pitching
CHICAGO -- One day after Brian Bogusevic pitched for the first time in his Major League career, the Astros outfielder was hitting in the nine-hole against the White Sox.
"I didn't even think about that," manager Brad Mills said of the lineup. "I'm probably going to get some grief on that from him. I thought it just balanced out everything to have him in there."
Bogusevic was drafted by the Astros as a pitcher in 2005 before converting to an outfielder. Mills said the right fielder's arm wasn't too sore after pitching one inning against the Cardinals in Thursday night's 14-2 St. Louis route.
"He was fine when he came in, and he'll probably go out and play catch and feel it a little bit, but I think he's OK," Mills said.Bogusevic drilled a three-run homer in the ninth to give the Astros their final 8-3 margin of victory on Friday.

subset: commoncrawl


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we have few long term deposit with bank , how to disclose this fixed deposit in schedule VI balance sheet . whether accrued interest on fixed deposit is part of fixed deposit or other current assets. for calculation of CRAR how much risk should be assigned on this assets "0" or 100%.
As per schedule VI:
Cash and cash equivalents
(i) Classification shall be made as:
(a) Bank balances;
(b) Cheques, drafts on hand;
(c) Cash balance;
(d) Cash equivalents – short-term, highly liquid investments
that are readily convertible into known amounts of cash
and which are subject to an insignificant risk of changes in
(e) Others (specify nature).
(ii) Earmarked bank balances (e.g. unpaid dividend) shall be
separately stated.
(iii) Balance with banks to the extent held as security against the
borrowings, guarantees, other commitments shall be disclosed
(iv) Repatriation restrictions, if any, in respect of cash and bank
balances shall be separately stated.
(v) Bank deposits with more than 12 months maturity shall be
disclosed separately


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This product is no longer available.
You can try these similar gifts instead.
Layered Wax Drawing Kit
It's the phrase every parent dreads: "I'm bored". Banish boredom with this unique craft kit inspired by a centuries-old art technique. Kids create drawings with oil pastel, then layer with colored bees wax.


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Open Office spellchecker just wont work!!
I am having problems gettint he OpenOffice spell checker to work. I turned on my linux box oneday, feeling like doing some work and what do you know, no spelling errrors are showing up. And its not as though I have a hundred percent accurate typing. I;d like to but... oh well.
I don't know if its because I am a n00bie or something else has gone wrong. My locale settings are set to English (Australia) and my default language for documents is also set to English (Australia).
Under the writing aids tab, the openoffice spell checker is enabled so I can't work out what the problem is.
I found that English(Australia) doesn't work, but English(US) does. But English(US) doesn't pick correct spelling like "colour" as an error.
Yes.. that would make a lot of sense seeing as the English (US) language setting has a spelling icon next to it....
I knew it would be somthing stupid like that....
|All times are GMT -5. The time now is 12:51 AM.


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Avocado Blues
Red Hot Chili Peppers
Still in the "less is more" vein, I've been experimenting with covering as much area as possible with a single color before laying down a new one. The results have been very satisfying as well as liberating! Not being overly distracted with all the wonderful details in my subject has allowed me to paint my subject "how I think it should be."
And lastly, I've been working on developing strong value patterns early in a painting; which also speaks to the graphic designer in me! Whether or not a graphic design piece can communicate at all is dependent upon proper value contrasts between the individual elements in the design. Successful paintings hinge on this rule as well, and I think these paintings demonstrate good contrast.


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EUR/USD (a 4-hour chart)
General Overview
EUR/USD made a bullish reversal on Friday after U.S. jobs report that caught many by surprise with negative European data. Will it be a short-term rebound in the value or it will become a mid-term trend? The data stream will be focused on Syria and only some of the Eurozone data will come out today. EUR/USD traders are likely to react to the U.S. data, news on Syria and various related markets, including those in other asset classes.
According to the Ichimoku analysis the pair is located in the medium uptrend on the daily chart. Still the pair is falling on the 4 hour time-frame. The EUR/USD broke the Ichimoku cloud down. Tenkan -Sen and Kijun -Sen are directed upwards. Tenkan -sen is below the price. The cloud is directed down.
Bollinger bands are directed up broadening.
The MACD histogram has left a negative zone.
Trading recommendations
We recommend selling at the current price to target 1.3067. If the level is broken, the decline to the next support at 1.3021 will be possible.


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Good Samaritan Hospital Recognized as StormReady Supporter
Good Samaritan Hospital in Kearney has been recognized by the National Weather Service in Hastings as a "StormReady Supporter".
Beingconsidered a StormReady Supporter means the hospital has paid special attention to the severeweather preparedness for their staff and visitors. Good Samaritan has provided trainingsessions regarding the hazards of severe weather and safe practices for dealingwith such conditions.
The hospital maintains a clear awareness of developing severeweather situations amongst all facilities and adheres to a well devisedsevere weather operations plan.
A ceremony was held Tuesday to honor Good Samaritan Hospital. A certificate of achievement will be handed out to recognize the staff. A presentation was also given from NWS staff covering winter weather safety and awareness.
Since1999, the NWS sponsored StormReady program has recognized over 2,000 counties,municipalities, universities and other organizations as StormReady. More informationabout StormReady is available at their website.


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Here's a shout out to all those in the San Francisco Bay Area. This weekend on June 7 and 8, there is the Green Fair Silicon Valley where there will be seminars, speakers and exhibitors explaining and educating people how to be more green. Will Durst and Ed Begley Jr. will be speaking, for $10 it's pretty cheap and if you ride your bike they give you five dollars off. I've been the green festival in S.F. and hope that I'll be able to rearrange my schedule to check this one out.
Another conference that I would really like to go to is Towards Carfree Cities VIII in Portland, OR from June 16 - 20, 2008. They are going to be webcasting some of the seminars, so even if you can't make it, it might be worth checking out online (another way to make things carfree)
We are no longer just a novelty, it's not longer just a movement, it's a new way of living and in the future we wonder what the fuss was all about. Really we will.


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Doyle dreaming of Euro glory
Striker Kevin Doyle has revealed Giovanni Trapattoni has challenged Republic of Ireland's players to 'do a Greece' at Euro 2012.
Last Updated: 21/05/12 10:54pm
Striker Kevin Doyle has revealed Giovanni Trapattoni has challenged Republic of Ireland's players to 'do a Greece' at Euro 2012.
The odds are stacked against Trapattoni's team as they have been drawn in a group which also includes Spain, Italy and Croatia.
But Doyle and his team-mates are being repeatedly reminded of Greece's sensational upset win under another veteran Otto Rehhagel in 2004.
Doyle said: "If you are in it, you have a chance. I don't think it's madness.
"The manager has used the example plenty of times of Greece. But the toughest part really is getting out of our group because it's so difficult.
"But it shows whenever we play the big teams, we compete and do well in these tournaments.
"We seem to get out of the group stages - the quarter-final in 1990 and the World Cup in 1994, we got through the group, and the (2002) World Cup, we got through the group, so we have a good history when we have been involved in the Euros or World Cups.
"We have all seen Irish teams do well in World Cups, so hopefully that will rub off on us."
Doyle, who is set to lead the line alongside skipper Robbie Keane this summer, believes the Republic have shown in the recent past they are not to be underestimated.
Italy failed to beat them home or away in the last World Cup qualifying campaign, and succumbed 2-0 in a friendly in the Belgian city of Liege last summer.
For that reason, the 28-year-old does not expect any of their Group C opponents will take them lightly.
The striker said: "I hope not - Italy won't, I am sure, because they have experienced it three times in the last few years.
"Last summer was a great result for us and they will know what to expect.
"Our manager, I think, gets that little bit more excited when we are playing Italy than normal as well.
"He will know them inside-out and we will be prepared. They are a good team, Croatia, Spain - it's going to be very difficult, we are not stupid.
"But I am sure they are not thinking it is going to be anything but difficult against us as well."
Doyle joined up with the squad on Sunday having had some time to come to terms with his disappointment at Wolves' relegation from the Premier League.
He and club-mates Stephen Ward, Kevin Foley and Stephen Hunt could be forgiven for feeling down in the dumps, but the former Reading forward claims the emotion is very different.
He added: "The opposite. It's a release. It's great to have this at the end of a very tough season, to be able to finish on a high note, hopefully.
"There are four of us from Wolves in the squad and we have all said the same thing. We have had a reason to keep going the last couple of months to make sure we were right for this.
"A few of the Wolves lads were jealous. It has been such a tough season, and they had to go off and try to forget about it.
"We have got this to be excited about and to have something really brilliant to look forward to.
"It's kept us going, definitely. I am really looking forward to it now."
Doyle will return to his club after the finals to start work with a new manager in the shape of Norwegian Stale Solbakken, and that too is a challenge he will relish.
He said: "I am excited. He had a season like us last year, but apart from that, he has been very successful.
"Stephen Kelly and Damien Duff play with (Brede) Hangeland at Fulham, and he played under him and he told them he is very, very good.
"I think we have done well to get him."


text:
The Japanese hit back at problems with research & engineering solutions.
I've been told. Dreaming`s free.
Think I'll go, back to sleep.
Everybody listen, voices in my head
Everybody listen, do yours say, what mine says?
On the other side the chinese can and DO manufacture goods at a very high level. Often the factories are producing 'OEM' stuff for named European and American brands. HiFi is a good example of this. Those same companies produce high quality equipment at about 1/3-50% of the 'named brands' that is just as well made and has just as good components used. Some of the chinese bikes use japanese designed engines (yamaha/honda twins) Suzuki use china for the GN250.. it has been said the overall finish isnt as good, but the motors seem as robust as the original japanese manufactured ones.
If the road to hell is paved with good intentions; and a man is judged by his deeds and his actions, why say it's the thought that counts? -GrayWolf
Its like Korea and cars. I would totally buy a Hyundai (or at least put it on the shortlist). If they used to be shit, they arent any more.
but with the chinese made bikes available here, we're at the wrong part of the time/quality bellcurve, IMO.
And, to the OP, looking at the riding position of that (its a ripoff of the Honda Dream 50) it would be anything BUT a cruiser.
if your arse is that tight why are you buying a Honda?. - AllanB
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Twelve Chairs1970
Genre: Adventure, Comedy
Read the entire Twelve Chairs movie script | Buy this movie on Amazon
Share your thoughts on Twelve Chairs's quotes with the community:
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"Twelve Chairs Quotes." Quotes.net. STANDS4 LLC, 2017. Web. 19 Nov. 2017. <http://www.quotes.net/movies/Twelve Chairs>.


text:
This front air dam is manufactured from the highest quality urethane available for flexibility, durability, and impact resistance. All parts come unpainted.
Mesh grille is included if applicable.
Available for all 1983-1985 Mercury Capri 2dr hatchback models only.
Installation Notes:
This front air dam attaches to the factory bumper using double sided 3M tape & self tapping screws.
Detailed instructions and all necessary hardware is included. Professional installation is recommended.
Xenon part# 3129
Parts are usually shipped within 2-4 business days. For express delivery pricing and times, please call us. For international shipping quote, please call us or email us with your complete shipping address. To save on shipping, pick ups are available in Anaheim, CA. Shipping price includes handling and insurance (damage & loss).
Discounts Available:
For package deals or to purchase more than one item at a discounted price and combined shipping, feel free to call us for pricing.
Application Notes / Keywords (NOT FOR CUSTOMER REFERENCE):
On sale is this xenon polyurehtane poly urehtane poly-urethane front bumper cover addon add on add-on lip spoiler air dam apron chin lower wrap that will fit 1983-1985 83-85 mercury capri 2dr 2 dr door hb hatchback hatch back models ( 1983 1984 1985 83 84 85 ).


text:
Philippe Audibert
Women's Metallic Dangle Chain Hoop Earrings
Last seen for £35 at Lane Crawford.
Get notified when it's back…
We check over 450 retailers daily. Be the first to know when it comes back in stock.
Last seen for £35 at Lane Crawford.
See more Philippe Audibert Earrings.
We check over 450 retailers daily. Be the first to know when it comes back in stock.
Philippe Audibert renders cable chains with delicate sophistication in this fluid pair of dangle effect earrings. Pleasantly topped with a single clear Swarovski crystal, this is a design that can be worn both during casual and formal hours. Silver-tone plated hardware with cable chain hoop body. Single white Swarovski crystal post. Stud earring style with bullet nut safety back. Designer dust bag included. Made in France. 100% Metal. One size only. Color: metallic
Philippe Audibert items by category | All Philippe Audibert items | All Women's Earrings


text:
Not Accepting Guests
- Last login 21 minutes ago
Join Couchsurfing to see Armel's full profile. It's free!
About Me
save the world? huh, let's just start with smiling to people
They say I am generous, quiet but funny (because I try to be funny), curious person, appreciate humor (except british humor: sorry I don't understand you guys), value friendship and people true to their word.
Actually I asked my wife what she thinks of me so it's a bit cheating :p
I like teasing people. It's a way to break the ice. Sometimes, people with different cultures take it too seriously. I try to learn how to behave myself but it's so much more fun if we could all tease each other and laugh about it. :)
Let's bring joy and excitement and a bit of craziness!!
Why I'm on Couchsurfing
I have been hosting a lot in Vancouver and I met amazing people form so many countries. After we decided to travel around the world, it was time for us to discover the other side of Couchsurfing, surfing at people's place. We had such a great experience with couchsurfer, it's just magical that people put so much faith in it and invite us like royal guest. My best experience of Couchsurfing was in India with Muslim communities. We were treated in the most honorable way. So much that I felt ashamed being hosted by such generous families.
First I am a geek, but a stylish one I think. I like to take everything apart. Now I can't because my wife would give me that look. I love art in every form. I am quite handy. I did some pottery for few years and learnt carpentry so that I would create something I can use in my apartment. Yes I even built a bed for couchsurfers. As geeky as I am, I would buy all kinds of tools. :)
I am now back to kung fu as well, a martial art called Wing Chun. I believe in spiritual energy in the body and healing with energy like Reiki/Qi Gong.
Besides all that, I like to host friends for brunch, go snowboarding at Mount Seymour, hike with my Belgium friends to Tetrahedron Park, watch tv shows...
- arts
- beauty
- boating
- tv
- traveling
- pottery
- blogging
- hiking
- surfing
- snowboarding
- tourism
- mountains
Music, Movies, and Books
I am a Freddie Mercury fan. The greatest singer in history. I am from the old generation that loves hard rock but at the same time, I subscribe to the Vancouver Symphony Orchestra. My favorite composers are Rachmaninoff, Dvorak, Beethoven, and many more during Classic and Romantic era. I don't know anything about music, I don't play any instrument but I can really appreciate the music, especially when you can see a talented pianist few meters away playing Rachmaninoff.
One Amazing Thing I've Done
For a person that works a lot, I try to travel as much as I can. Raised in France was easier for me to discover many cultures next door.
One of the beauty during my travel is in Ha Long Bay in Vietnam. It's an amazing scenery. Imagine yourself on a boat, the water is quiet with no waves at all, the rain is light and the sky is dark with lightning. The view around you is full of mountains on little island. The rain is fresh and the water warm at the same time. Clouds are playing symphony and lights while you can observe the greatness of Mother Nature.
It all sounds scary but it actually felt peaceful in my mind.
That text was written two years ago, that was before I went with my wife travelling around the world. So What amazing things have I done? I can't tell you that in one sentence since we visited 20 countries in 5 continents but check out our blog: www.stephandarmel.tumblr.com
Here is where I have been since I was born:
visited 33 states (14.6%)Create your own visited map of The World or Free android travel guide
Countries I've Visited
Argentina, Australia, Austria, Bolivia, Cambodia, Canada, China, Ecuador, Germany, India, Indonesia, Ireland, Italy, Japan, Laos, Malaysia, Mongolia, Myanmar, Nepal, Netherlands, Peru, Russian Federation, Taiwan, Tanzania, Thailand, United Kingdom, United States
Countries I've Lived In
Canada, France, United States


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We believe that the main driving force in both science and art is the creativity. Artists create new realities, their imagination can run wild and they have a licence to experiment and push the boundaries. Scientists are not unlike artists, they just add a bit more of the analytical approach to exploration. We like to do both.
That moment when you realise that the purpose of your life might be fulfilled as the writing on the envelop says that you helped design a chocolate. And not one of them, but four! Pure ART.
Made of high quality dark chocolate, they are filled with various delicious things to reflect the taste of the 3D molecules: walnut and sage liqueur for ethanol, bits of coffee beans for caffeine, sweet dry figs for glucose and bitter chocolate for dopamine.
In collaboration with Marina Prijatelj from Croatian Choco Concept
Molecules That Changed the World installation is dedicated to the molecules that changed our culture, life and social trends. We have used stereoscopic 3D representation of the structures and additional textual information to illustrate, not only the history, properties and application of chosen molecules but also conflits between theory and applications, expectations and results which accompany the scientific discovery. Featured are 25 molecules including such as ammonia, carbon dioxide and polyethylene.
Done in collaboration with Bernd Lintermann, Centre for Art and Media, Karlsruhe, the installation can be accessed also through molecules web site.
App, which accompanies the exhibition is available from Google Play and ITunes store from May 2016.
Future is Here Ljiljana, together with Bernd Lintermann, curated Future is Here module within ExoEvolution, first large scale international exhibition dedicated to new technologies and art/ cience interface held in Center for Art and Media Technology, Kalrsruhe (31.10.2015- 28.02.2016). Three installations have been exhibited based on Fruk group research and interests.
Video (in German) is available here
Graphic design was done by Ruediger Mach in his MachIdee studio in Karlsruhe (fun and creative times).
Quintessence focused on DNA and its role in genetics and nanotechnology
Seeing the Invisible intereactivaley addressed the world of nanoparticles and nanostructures by putting the visitors in the position of the explorer. It employed retroreflective foil, nanomaterials samples and video projections to illustrate the most recent nanotechnological developments.
BANG!Matter/Dark Matter installation re-creates the visions of the known and unknown universe, presenting one of the possible truths on the matter of dark matter. It is a take on the universe, invisible dark matter and time, with scientific data being combined with artistic vision to compress billions of years into few minutes of the visual material shown on a panorama screen
Two of our images, Nanoflower (above) and titanium rods in motions were featured in Interalia magazine as images which aestetically represent the dynamics of microscopic and molecular processes. More can be found here.
Nano Warhol
We did this just for fun combining different TEM images that did not get into publications. This types of action we call: giving-public-life-to-unpublished- data.
Since 2010 we have been designing our group Nano Calendar featuring microscopic images of our nanomaterials. We even sold copies for charity. We will continue doing this in the future so keep tuned.


text: It's only been a week since G2 came to live with us and I am amazed at the variety of color and texture changes he does. I am still not sure on species. It seems as if he has put on size in the week I've had him. I'd say he's doubled which is amazing! Everytime I look in the tank he looks different. I took alot of shots today and got a pretty decent one of his eyespot. Looks broken and very different from Inklet. Inklet had his first Killyfish today. The local bait shop was out of crabs and Jess and I were off to a new pet shop up north which claims it is getting in a mimic octopus.....I'm not so sure on that, but they claim to have a source... I think Inklet injured himself somehow, as the one eyespot is gone and there is a white patch where it was, like he got stuck on something...I felt bad as he ever had his arm covering the spot when I noticed it a few days ago. He had curled the end of his arm exactly over the spot. Sure hasn't affected his appetite though!


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There is always a hue and cry about abortion rates and yesterday's coverage of a 4% rise in the numbers was no exception. But why does it matter? If you oppose abortion than any number will be too many. If you accept that a woman has a right to make these decisions for herself, than why does it matter if a few more, or a few less, choose to end pregnancies that they would rather not take to term? Why does a rising rate always have to be interpreted as a tragedy?
It could mean that a lot of women have decided that they don't want to live their lives swallowing hormone pills which in many cases, make them feel fat, grumpy and fed up with sex, and have decided instead to opt for the (relatively) higher risk of using a barrier method of contraception knowing that, if they do get pregnant, they will have a termination. For the majority of those who don't oppose abortion on moral grounds this is a perfectly rational, indeed healthy, decision. Only a tiny proportion of them will fall accidentally pregnant, the rest will avoid any of the possible side effects of hormone methods and, assuming that they are responsible and use barrier methods, they would be far less likely to contribute to our rising levels of sexually transmitted diseases. A rising abortion rate in these circumstances could be a positive benefit to the nation's health.
But the more likely reason for the rising level is that fewer, very young, pregnant teenage girls decided to have their babies last year. Figures for the previous year (2005) showed that, of the 334 under-14s who became pregnant, 58.4% terminated their pregnancies. That turns out (coincidentally) to be 4% fewer than the proportion in this age group terminating in 2004. Was that small drop in the 2005 abortion rate something to be celebrated? Would it be a bad thing if the proportion rose again the following year? Is it better or worse if more thirteen-year-old girls take their babies to term? I think that would depend on whether you believe that abortion is always murder. If you don't it is just possible than you might be glad that a slightly smaller number of children might have become mothers last year.
Yesterday's report made a lot of the fact that 19-year-olds have the highest abortion rate of any age group, as though this was somehow further evidence of the disintegrating morals of the nation. In fact research into comparative abortion rates suggests that the UK (in common with the US), has a relatively low rate of teenage abortion compared, for example, to Sweden and France. In the latter countries, far fewer teenagers get pregnant, but a much higher proportion of them opt for termination (Guttmacher Institute).
One of the reasons that the abortion rate is creeping up among the under-20s is because the government decided, seven years ago, to tackle the very high rate of teenage motherhood in the UK by setting up the Teenage Pregnancy Unit. The decision was made, (in common with other European countries), to focus on helping teenagers cope with sex and its consequences rather than trying to make them abstain from it. But if people have sex then there will be unwanted pregnancies - because, as the anti abortionists are always very quick to point out - pregnancy is the normal outcome of sex. It will happen unless that process is interrupted in some way. If we want fewer teenage mothers, and we don't (or can't) stop young people from having sex altogether then we have to accept a higher abortion rate because young people (oddly enough) are not always responsible about contraception. It isn't complicated.
Age-related abortion rates are in any case misleading. Nineteen-year-olds have a higher rate than 14-year-olds because more of them get pregnant, but in fact proportionately more 14-year-olds have abortions than do 19-year-olds. Those between 24 and 35 have a low rate because, though they are the group most likely to get pregnant, they are the least likely to have abortions. What this actually tells us that, in spite of the occasional fluctuations, women are making rational decisions about when they want to become mothers.
It would be good (for the women concerned) if fewer got pregnant by accident because having an abortion is always distressing, and it is teenagers who are most likely to fall into that group. But then teenagers are more prone to every form of accident because they are out in the world for the first time and testing their wings. Sometimes they make mistakes. We all hope that the mistakes will be small ones, and that we can help them to recover, adjust and, yes to learn from them. If you think abortion is murder then you will certainly feel that a termination would be the wrong way to deal with such a mistake. But if you believe that abortion is a rational option for women who don't want to be mothers then why would you care about the number of 19-year-olds who had a termination last year?


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Redshirt linebacker Tray Blackmon and defensive end Alonzo Horton were two of the top signees in the 2005 signing class. On Tuesday, they both had big plays in the redshirt scrimmage.
Premium Content
Subscribe today to read the full article and get everything Rivals has to offer.
- Member-only message boards
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text:
It's a time-honored soccer tradition: The person carrying the armband carries the trophy.
While in American team sports it's often the team owner that gets the privilege, in soccer it's typical for the captain to be the first to hoist the silverware after a championship victory.
Last night at Rio Tinto Stadium, D.C. United manager Ben Olsen bucked both trends.
More from The Sideline
The ex-D.C. United player, now in his third full year as the Black-and-Red's coach, first carried the Lamar Hunt US Open Cup trophy to his team captain, Dwayne De Rosario, and then helped him raise it in celebration.
Those who are bothered by it, may want to watch the video below before they're too hard on Olsen. He loves the club and it shows. And despite a 3-21-6 regular-season record, his team is also right behind him.
Want to know why? Watch his locker room speech below (beginning at the 3:25 mark):


text:
Thanks to our friends at Herbalife for sharing this video!
Hear what Major League Soccer star and MLS Cup MVP, Omar Gonzalez has to say about his success. Omar is a key player on the LA Galaxy. He shares his thoughts on his season, his injury, his recovery and how it felt to be named Most Valuable Player.


text:
Middle East Requires Over 1,920 Aircraft Worth Over $347 Bn
- Aircraft fleet to almost treble in the next 20 years
The main drivers of the continued strong demand for new aircraft include fleet expansion and replacement, greater urbanisation, an increasing number of mega cities and the overall ongoing expansion of the region as a geographical hub and tourist destination. With today's aircraft capabilities every major destination around the globe is within reach of a direct flight from the Middle East.
Related Research on ASDReports.com:
International Military and Civilian Unmanned Aerial Vehicle Survey
International Military and Civilian Unmanned Aerial Vehicle Survey
These factors are driving an above average passenger demand growth rate of 6.4 per cent per year which is well above the world average 4.8 per cent over the next 20 years. This above average growth rate will result in the almost trebling of the regions fleet from over 800 aircraft today to some 2,260 by 2030.
Middle Eastern carriers are increasingly choosing larger aircraft due to the growing number of global hubs in the region, and particularly within aircraft families for the reduced training and maintenance costs, reduced fuel burn and environmental benefits they bring.
The region's new passenger aircraft requirement includes: 779 single-aisle aircraft, such as the A320 Family valued at US$57.3 billion; 801 twin-aisle aircraft such as the A350 XWB valued at US$179.8 billion and 302 very large aircraft (VLA) such as the A380 valued at US$99.2 billion. Of these 1,442 aircraft will be necessary for growth and 440 for replacing ageing aircraft with newer more eco-efficient models. In the freighter aircraft category, there will be a demand for 13 twin-aisle aircraft and 26 VLA aircraft.
"The Middle East remains one of the world's most robust aviation regions and this is confirmed by a 200 per cent increase in inter-regional passenger traffic over the last 10 years," said John Leahy, Airbus Chief Operating Officer, Customers. "The region is uniquely placed with more than 85 per cent of the world's population within reach of a direct flight, making the Middle East a fertile market place for our eco-efficient aircraft today and beyond."
Globally, there is a move towards larger aircraft in all size categories to help absorb growing passenger numbers despite infrastructure constraints. The region is already the world's busiest for the world's most advanced aircraft, the A380, and this will continue to increase.
Source : Airbus, an EADS N.V. company (Paris: EAD.PA)
Introduction to Aircraft Appraisals and Valuation Seminar
Dec 4, 2017 - London, United Kingdom


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From the release notes:
- Improved JBI support including both interface based routing as well as service based routing together with improved WSDL parsing
- Support for Publish Subscribe Routing
- Improved JAX WS support
- Migration to XBean as the XML configuration mechanism which works with any Spring release and allows us to mix and match ServiceMix configuration with other XML configuration mechanisms like ActiveMQ and Jencks
- Migration to backport.util.concurrent to make it easier to move direct to a pure Java 5 solution.
- a new Loan Broker example from the EIP Patterns Book
- a new simpler POJO based deployment model
- build reorganised to make ServiceMix more modular
- a new ChainedComponent which implements simple pipelines of components easily
Are you using a JBI container or other enterprise service bus currently? What features do you look for in an ESB container, or what would make you use a specific one?


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Dear teachers,
I have three questions to ask:
A new economic recession has set in for that country.
I know "set in" means "start". My question is: Is "set in for" a phrase?
We can say "set to work". But in Random Dictionary there is "set about work". Does it mean the second phrase has been accepted?
We wnet along a road that led down into a valley, about a mile out of town, where there was a pond. I think the underlined parts are attributes. Is that right?
Looking forward to hearing from you.
Thank you in advance.
Student or Learner


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As expected the Big Bazaar has come up with this year's Sabse Saste 5 Din (Lowest prices 5 Days) Sale for Republic Day 2012. The sale is on from January 25, 2012 and January 26, 2012 and is on till January 29, 2012. As a special feature the stores wil be open from 9 a.m. onwards itself rather than 10 for these 5 days. There are going to be a mad rush definitely for sure for this year's sale as they have loaded it with even better offers and deals to choose from on various categories.
This special offers are also available online at Futurebazaar.com (if you feel you cannot visit the store or don't have any Big Bazaar Store in your locality). Do check it out to find all the offers on Big Bazaar Online there and get it delivered to your home for free.
The Payback card holders might have enjoyed this special sale of Sabse Saste 5 Din yesterday itself as Big Bazaar has arranged a special preview sale for them yesterday!
The above sale is on the Food Bazaar, Electronics Bazaar, Furniture Bazaar, Mobiles, Apparels, Home Needs, etc.
Some Special Offers Shared (original price in brackets)
- Mitashi 24 inch LCD and DVD Player at Rs. 10,990
- Samsung Galaxy Y – Rs. 7649 (Rs. 8750) with free laptop bags
- Blackberry Curve – Rs. 10,699 with free mobile puch, screen guard, and Reebok Shoes
- Koryo 32 inch LCD TV at Rs. 14690
- Olympus 14 MP Camera – Rs. 3990
- Akai LED TV – Rs. 19,990
- Prestige 3 burner glass top gas stove + 3 L pressure cooker + nonsick cookware set + sandwich toaster + Stainless steel dinner set – Rs. 7095 (Rs. 12320)
- Combo offers or sunflower oil, basmati rice and atta
- Prestige Induction Stove, cooker, tava and fry pan – Rs. 4095 (Rs. 6840)
- Lowest Prices on all Daily Needs and home needs
You can avail buy 1 get 1 and buy 2 get 2 and exclusive combo offers on all apparels for men, women and kids including shoes, etc.
All the above offers mentioned vary from store to store and city to city, hence do visit the nearest Bigbazaar store to find them out yourself and get drenched in great offers for this Republic Day.
There are lots of other offers are on store for furniture, travel needs, home needs, home fasion (like carpets, quilts, bedsheets), mobile phones, electronics, etc exclusively only on this Sabse Saste 5 Din Sale Days and hence try to visit your nearest Big Bazaar to find the best offer for you and catch it up early to avoid the rush during the peak hours. I would suggest you to visit the store at mornings on weekdays during these 5 days to shop peacefully and with enough time.
If you wish to receive more such offers and deals delivered daily in your email or feed reader, you can actually subscribe to these posts via email or through a blog reader.


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Originally published October 30, 2012 at 5:30 AM | Page modified October 30, 2012 at 10:56 PM
Tuesday TV Picks: 'Ellen DeGeneres: The Mark Twain Prize' on KCTS
TV picks for Tuesday, Oct. 30, 2012, include "Ellen DeGeneres: The Mark Twain Prize"; the 1946 film "Bedlam" on TCM; NBC's "The Voice"; and "NCIS: Los Angeles" on CBS.
Tonight in Prime Time
'Ellen DeGeneres:
The Mark Twain Prize'
The comedian/talk-show host becomes the 15th recipient of The Kennedy Center Mark Twain Prize for American Humor during this ceremony. The guest list looks amazing (Kristin Chenoweth, Jimmy Kimmel, Jane Lynch, Lily Tomlin, Loudon Wainwright III), so tune in if you feel like a good laugh. 8 p.m. Tuesday on KCTS. (seattletimes.com/tvlistings)
Doug Knoop, Seattle Times staff
firstname.lastname@example.com or on Twitter @dougknoop
Also on Tuesday
"Bedlam" (1946), 7:30 p.m. (TCM): A portly lord sends an 18th-century London actress to a madman's insane asylum.
"The Voice," 8 p.m. (NBC): Vocalists from each team compete against each other.
"The Looney Tunes Show," 8 p.m. (Cartoon Network): Bugs' small lie to Porky snowballs, prompting Daffy to join the U.S. Marines.
"New Girl," 9 p.m. (Fox): Jess is hired to be a zombie at a haunted house; Cece and Schmidt accidentally wear perfectly matched costumes; a former college crush visits Nick and expresses her affection in an alarming way.
"NCIS: Los Angeles," 9 p.m. (CBS): A CIA agent who once worked with Sam seeks his help before dying of an apparent suicide; while working under cover, Deeks and Kensi enter a prized poodle in a dog show.
"Don't Trust the B — in Apartment 23," 9:31 p.m. (ABC): June tries to stop Chloe from ruining her favorite holiday with her elaborate tricks; James throws a Halloween party.
The New York Times


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Top U.S. banks are in the process of releasing first-quarter 2014 results, likely to reflect the tough backdrop endured by the sector since the beginning of the year.
The first to report earnings was Wells Fargo & Company (WFC - Free Report) , which beat estimates by a decent margin. But numbers from JPMorgan Chase & Co. (JPM - Free Report) lagged behind estimates by a wide margin. However, Citigroup Inc. (C - Free Report) reported impressive first-quarter 2014 results, following Wells Fargo's lead.
JPM Disappoints
JPMorgan Chase failed to override industry conditions and delivered a negative earnings surprise of 9.2%. The banking giant came out with earnings of $1.28 per share, missing the Zacks Consensus Estimate of $1.41 by a wide margin. This is also significantly lower from the year-ago number of $1.59.
However, it would not be unjustified to blame industry-wide headwinds, as the company was largely unaffected by settlements of legal disputes. A lower level of consumer and corporate activities, soft trading volumes and sluggish mortgage banking dragged earnings this time around. Moreover, fundamental pressure from a low interest rate and sluggish loan growth made matters worse.
WFC Beats
However, Wells Fargo earned $1.05 per share in first-quarter 2014, thereby achieving earnings growth for the 17th consecutive quarter. Results improved from $1.00 earned in the prior quarter and 92 cents in the year-ago quarter. The reported figure also beat the Zacks Consensus Estimate by 8 cents.
Despite negative market sentiment, shares of Wells Fargo increased marginally in the pre-market session, indicating that investors have been bullish on the results. The price reaction during the trading session will give a fair idea whether Wells Fargo has been able to meet market expectations.
Citibank Impresses
Following a disappointing second-half 2013, Citigroup reported impressive first-quarter 2014 results. Earnings per share came in at $1.30, outpacing the Zacks Consensus Estimate of $1.18. Moreover, earnings surpassed the prior-year period earnings by a penny.
Shares of Citigroup jumped around 3.7% in the pre-market session, indicating that investors have been bullish on the results. The price reaction during the trading session will give a better idea whether Citigroup has been able to meet expectations.
What Did They Get Right?
Both Wells Fargo and Citibank's success was a result of prudent expense management. In Wells Fargo's case total loans and deposits grew. Moreover, a strong capital position and returns on assets and equity acted as the positives. But more importantly, the company recorded reduction in non-interest expenses.
Wells Fargo also reported $500 million in reserve release (pre-tax), attributable to its improved credit performance. However, the company experienced a fall in its top line owing to lower non-interest income.
Better expense management was the driving force behind Citigroup's better performance as well. Total costs of credit for the first quarter at Citigroup were down 20% year over year to $1.97 billion. The improvement was primarily attributable to a decline in net credit losses and reduced provision for benefits and claims.
The Bottom Line
Going forward, expense management may well be the key factor which determines a bank's success and failure. Moreover, reserve releases for most banks are not expected to be strong enough to support bottom-line growth similar to the past year. Only continued expense control and stable balance sheets can make bank stocks desirable in the upcoming quarters.
Below we present two banking stocks which possess the potential to grow appreciably and are slated to report soon, each of which also has a good Zacks Rank and is poised to exceed estimates.
BNC Bancorp
BNC Bancorp is the holding company for the Bank of North Carolina. A full service commercial bank, it offers a large number of banking services. It conducts both retail and business banking operations. Earlier this month, the bank completed a merger with South Street Financial Corp.
The company holds a Zacks Rank #1 (Strong Buy) and has expected earnings growth of 30.40% for the next financial year. The forward price-to-earnings Ratios (P/E) for the current financial year (F1) is 15.22. This stock has a positive earnings ESP of 8.33%
The First of Long Island Corporation
The First of Long Island Corporation (FLIC - Free Report) is also a holding company for a bank. Its wholly owned subsidiary is The First National Bank of Long Island. Besides commercial and retail banking, it has an investment banking division and an insurance agency. Another subsidiary, FNY Service Corp, is an investment firm.
Currently the company holds a Zacks Rank #2 (Buy), and has expected earnings growth of 11.40% for the next financial year. It has a P/E (F1) of 15.43. The stock has a positive earnings ESP of 3.45%.
The banking environment remains fraught with challenges and yet some stocks have the ability to outperform the sector. These two choices have the ability to post good earnings numbers and would make excellent additions to your portfolios.Read the Full Research Report on JPM
Read the Full Research Report on WFC
Read the Full Research Report on C
Read the Full Research Report on BNCN
Read the Full Research Report on FLIC
Zacks Investment Research
In-Depth Zacks Research for the Tickers Above
Normally $25 each - click below to receive one report FREE:
J P Morgan Chase & Co (JPM) - free report >>
Wells Fargo & Company (WFC) - free report >>
Citigroup Inc. (C) - free report >>
The First of Long Island Corporation (FLIC) - free report >>


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Utah didn't need a Pac-10 label to sell itself to recruits.
But it sure hasn't hurt.
Article Continues Below
Utah has become a Top 25 regular with two BCS bowl wins in the six years, but the Utes became an even more attractive destination for elite recruits this past offseason following the announcement they would leave the Mountain West for the Pac-10 in 2011.
"It actually played a big role in me deciding I wanted to go there," Moreno Valley (Calif.) Rancho Verde cornerback Ryan Henderson said. "I was saying I wasn't going to settle for anything less than a Pac-10 school.
"I was interested in them a little bit, but when they ended up joining the Pac-10, it definitely influenced my decision and it boosted them up a lot. It pretty much boosted them up immediately."
But Utah coach Kyle Whittingham hasn't been hammering home the Pac-10 move as part of the team's recruiting strategy.
"I talked to pretty much every coach and they didn't really push that," Murrieta (Calif.) Vista Murrieta quarterback Derrick Brown said. "They just told me what you'll get here and how the offense fits me.
"I was at first surprised they didn't push it more but then I thought they don't really have to. Utah is a big-time program. Going to the Pac-10 is an added bonus. If you want to play at a winning program, Utah is a winning program and a good program, too."
Conference realignment was the story line of the offseason, with the Pac-10 helping drive the news. The league also snagged Colorado from the Big 12, and tried luring Texas, Oklahoma and others to form a mega-conference.
No longer did Utah need to fight a perceived lack of respect by the big boys, the six BCS leagues. The Utes went undefeated in 2008 and beat Alabama by 14 points in the Sugar Bowl, yet finished second (AP) and fourth (coaches) in the rankings behind one-loss teams. In 2004, an Urban Meyer-coached Utah club went unbeaten, drilled Pitt in the Fiesta Bowl and finished fourth in the AP and fifth in the coaches' poll.
Whittingham said moving to the Pac-10 could help recruiting in California, but it might not have much of a factor with other prospects closer to campus.
"It's maybe a little territorial," Whittingham said. "People we recruit in California are obviously tuned into the Pac-10 and that's big with them, conference affiliation, so it's a little bit of both. Geographically, it certainly factors into the process.
"We focus on our university on what we offer academically and athletically. … The most important thing is what we can offer here at the University of Utah."
But there's no doubt that moving to the Pac-10 means more national exposure, more money for the school and more chances to play in better bowl games.
Those are three of the reasons why Henderson and Sugar Land (Texas) Dulles running back Jarrell Oliver committed to the Utes.
Oliver, rated as the No. 33 running back nationally by Rivals.com, had offers from SEC, Big Ten, Big 12 and other Pac-10 schools. But Utah stuck out because it was transitioning to a major conference. Turning down programs in those major conferences to play in the Mountain West might have been seen as a downgrade.
"The Mountain West was OK," Oliver said, "but when I heard the news we were going to the Pac-10, it gave it a little bit more boost because that will bring in more money and more coverage. We'll get more exposure. Nobody wants to go to the WAC or Conference USA. They want to think bigger and the Pac-10 or the Pac-12 is definitely a bigger stage."
A bigger stage will also bring more competition. The Mountain West is no pushover conference with TCU and BYU, and Boise State joining, but the idea of competing every week against more highly regarded opponents is attractive to recruits, who are confident Utah can compete.
And with the added exposure, the California players think many from their state will give the Utes a closer look during recruiting.
"It's going to play a big factor because people are going to start seeing how good Utah is and how good they can be," Henderson said. "They'll start seeing them as a very good football team when they start beating these schools. I definitely think it's going to play a factor with California kids going to Utah."


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My grandfather would sit eating these chicken crisps at night, the way we eat chips while watching television today.–Joan Nathan
LC Nose to Tail Note
Sounds like Joan Nathan's grandfather was a nose to tail eater without even knowing it. Notice how the meat, fat and skin of the chicken all have uses? The only thing we're missing direction for is the chicken carcass, and luckily we have a great recipe for homemade chicken stock that will take care of that.
Crispy Chicken Skin Recipe
- Quick Glance
- Makes about 1 cup
- 1 large chicken (at least 5 pounds)
- 1 large onion, chopped
- Kosher salt
- 1. Remove the fat and the fatty skin from the chicken. Slice the skin in small strips, approximately 1 inch long, measuring about 1 1/2 cups. Reserve the chicken for another use.
- 2. Place the skin and onion in a heavy skillet. Cook for about 20 to 30 minutes over a low heat, stirring occasionally with a wooden spoon, until the fat is melted. As the skin cooks, the fat separates from it, and the skin becomes crispy.
- 3. Once the fat has mostly melted, turn up the heat to medium-high and continue to cook until the onions and skin are golden brown to black. Sprinkle with kosher salt to taste. Using a slotted spoon, remove the crispy skin and onions from the pan and place them on heavy paper to drain. Reserve the chicken fat in the pan or store in a jar. The fat can be used for cooking and is especially good for making chopped liver, potato pancakes, and matzoh brei (matzoh pancakes).
Hungry for more? Chow down on these:
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Hexachlorobenzene uptake by Fathead minnows and macroinvertebrates in recirculating sediment/water systems
- 56 Downloads
- Citations
Fathead minnows (Pimephales promelas), the worm,Lumbriculus variegatus, and the amphipodsHyalella azteca andGammarus lacustris were exposed to hexachlorobenzene (HCB) in water with and without a bed of HCB-spiked sediment. Water HCB concentrations were maintained by recirculation through HCB-packed columns. Recirculating HCB-bound particulates and possibly eroded HCB particulates were an added source of HCB in addition to the sediment bed. Significant bioaccumulation of HCB in animal tissues was observed in water-only and water-sediment exposures. The presence of the HCB-spiked sediment did not result in a significant increase in the uptake of HCB by the organisms, but there was a substantial increase in sediment HCB levels over time. Higher tissue HCB levels in aquaria without sediment suggest that the sediment was a more efficient sink for HCB than the organisms.
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Relatives of an 87-year-old woman who died after a nurse at her retirement home refused a 911 dispatcher's pleas to perform CPR expressed satisfaction with the care she received, saying her wishes were to die naturally.
Lorraine Bayless' death last week at Glendale Gardens, a Bakersfield independent living facility, prompted outrage after a 7-minute recording of the 911 call was released.
Meanwhile Lorraine Bayless' family released a statement to news media. It reads in full:
"Our mother and grandmother was a remarkable and intelligent woman who was blessed to have a great life of 87 years. It is the wish of our family to honor and celebrate her life at this personal time.
"Like so many seniors, it was our mother's wish to live independently. She was fully aware that Glenwood Gardens did not offer trained medical staff. Even so, she personally selected the senior living community, and our family has come to know the staff and been very pleased with Glenwood Gardens as her home.
"It was our beloved mother and grandmother's wish to die naturally and without any kind of life-prolonging intervention. Our family respects the right of all people to make their own life choices in such cases.
"We regret that this private and most personal time has been escalated by the media. Caregivers, nurses and other medical professionals have very difficult waters to tread in the legal and medical landscape of our country today.
"We understand that the 911 tape of this event has caused concern, but our family knows that mom had full knowledge of the limitations of Glenwood Gardens, and is at peace. We also have no desire, nor is it the nature of our family, to seek legal recourse or try to profit from what is a lesson we can all learn from.
"We wish to focus on our family at this time, and this will be our final comment on this personal matter."


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At Gemvara, we believe that the jewelry you wear should be as unique as you. Every beautiful Gemvara solitaire september birthstone jewelry design will be made just for you. It's jewelry for all life's occasions, from an anniversary or holiday to your own personal milestones and celebrations. Choose a Quincenera gift shell treasure her whole life. Gemvara uses only the highest quality materials to craft your solitaire september birthstone jewelry with meticulous attention to detail. Our precious metals are recycled or responsibly mined. The September birthstone, sapphire, is most popular in gorgeous rich blue but lucky September babies can also choose sapphire in pink, yellow and white (or all four!). Our wide selection of solitaire september birthstone jewelry by Damon Washington, Carl Ansley, Gemvara Essentials, and other talented designers means you can find rings, earrings, and necklaces that are exactly your style. You can also shop by style, choosing our Pure, Vintage-Inspired, or Zodiac Collections. Our solitaire styles have exceptional brilliance: the center gemstone is perfectly proportioned to dazzle. When our work is done and you open that box, you'll see your design is even more beautiful when brought to life in the finest precious materials.
We can help right away. Chat with a jewelry expert now!


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ZWCAD Design has integrated a new annotation technology, SmartVoice, into ZWCAD+ 2014. It allows users to easily save voice information as an entity in their drawing rather than traditional text.
According to the company, SmartVoice makes onsite review more efficient by allowing users to add annotations through vocal message. Simply by talking to the drawing, project reviewers can freely add comments at anytime encountering a fault in the construction site. Using SmartVoice, every saved message will be displayed as a microphone icon, even with the longest comments never taking up more than an icon's space, and as a result designers can add annotations without cluttering the drawings.
"Many designers have got used to make annotations in the traditional way just because the majority is doing the same," said Daniel Huang, product manager of ZWCAD+. "While we find there is still room to improve the annotation efficiency after ZWCAD+ 2014's debut for nearly a month, SmartVoice has proven to be a powerful tool for fast and efficient annotation."
For more information, visit ZWCAD Design.
Sources: Press materials received from the company and additional information gleaned from the company's website.


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NEW YORK (AP) – Stephen Colbert says on a visit to the late-night show he'll take over next year he's obviously "thrilled" to be succeeding David Letterman.
The Comedy Central host told Letterman on CBS' "Late Show" on Tuesday he's going to do whatever Letterman has done. Letterman urges against it, saying, "You don't want to do that."
Letterman greeted Colbert warmly and offered an endorsement, saying CBS "could have just as easily hired another boob" like him.
Letterman is retiring next year. The "Late Show" released a 90-second clip of Colbert's appearance, taped for broadcast Tuesday night.
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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Unlocked the bootloader from Sony's site
Downloaded the SDK
Flashboot flash boot boot.IMG
And installed cm.zip from the sdcard.
It worked, in fact, I am typing this from my newly ROM'ed xperia.
So, the question is , if I want to install another ROM now, say CM11 or even a complete different one from xda , what is the process?
Do I just copy the new zip, boot into recovery, and wipe wipe install?
Or do I need to reflash the new boot.IMG from the new ROM every time?


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A few questions before buying?
- Hi everyone, I am coming from a BB9700, and have a few questions about the epic. I have seen a few posts about the root process and want to know if the one step root still works. Also how hard is it to unroot for a return if something breaks. The last part is whats the general number of apps you can install, I know every apps is diff and since 2.2 isn't available yet you cant store to SD unless your rooted. Thanks in advance guys, I know you wont disappoint.12-10-2010 06:12 PM
- Hello . I havent rooted my phone but the app for 1step root in the market from what I have read works....
To return back to stock is fairly easy . I updated to 2.2 but was having some problems with it. You can read up on this here http://forum.androidcentral.com/epic...ked-phone.html READ IT ALL FIRST THEN AGAIN. I thought I read it all and messed up my phone. very scary. But i reread it and it worked out so now I'm back to stock.
The amount of apps all depends on their size. you can fit about 500 apps of 1mb or less or 50 apps that are 10mb. I have yet to fill up my phone and I Have had about 7 pages of apps at 1 point.
I would suggest playing with the phone so you can get the feel of the keyboard. Some people didn't like the size and/or feel.
And if you use the search you can find alot of great information here.
Goodluck and enjoy your next (Android) powered Phone12-11-2010 08:10 AMLike 1
- The one click root tool works perfectly, and if you do end up messing up your phone, you can always restore it and/or unroot it if necessary. I've screwed up a couple of things before and was always able to restore it using this method:
[How To] Return to Stock / Fix Bricked Epic - xda-developers
Not sure about the apps, i have Froyo and i have a lot of apps and my phone still is mostly free in internal memory.12-11-2010 09:42 AM
- Forum
- Samsung Android Phones
- More Samsung Phones
- Samsung Galaxy S
- Sprint Epic 4G
A few questions before buying?
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Miles from Tomorrow: Let's Rocket DVD
Starring Olivia Munn, Cullen McCarthy, Fiona Bishop, Dee Bradley Baker, Tom Kenny, Grey Griffin, Diedrich Bader, Danny Jacobs
Five two-part episodes from the first season of the animated Disney Junior series about the adventures of Miles Callisto (voice of Cullen McCarthy) and his family as they travel through space aboard the Stellosphere.
In this instalment, the Callistos, who work for the Tomorrowland Transit Authority, have their spaceship stolen by a daring thief, get swallowed by a giant alien and try to stop a trapped pilot from crashing into one of Jupiter's fiery moons.
The episodes are: 'Runaway Shuttle/Surfin' the Whirlpool', 'Ocean in Motion/Explorer Exchange', 'Game On/How I Saved My Summer Vacation', 'Who Stole the Stellosphere?/Rock 'N' Roll' and 'To the Goldilocks Zone/Hiccup in the Plan'.
- Format: DVD
- Region: 2
- Certification: (U)
- Catalogue number: BUA0254801
- Studio: Walt Disney
- Release date: 29/02/2016
- Genre: Childrens
- Colour: Colour
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this week has flown by~ and I am feeling so behind...I had a long list of stuff I wanted to accomplish before both kids were out of school...not going to happen!!!
Here is a quick fly by post for Sharon's stamp simply challenge this week- half circles.
This card uses Lizzie Anne's Bless this nest set- I am feeling a bit different this week- went with a whole 'nother style than I usually do- But I like how it looks!
have a fabulous weekend!
Remember when uploading to use keyword ssnotime91- and here are the rest--Sharon, Julie, Janine, Jennifer, Tammy, Becky, Deb, and Sabrina
Pin It Now!
June 11, 2009
holy smokes...where do the days go?
Labels: Cards, cas, Lizzie Anne, Stamp Simply
3 comments:
- Katy said...
I like it too!! Just reminding you, I'm here -- I'm watching! Great, now I feel like a stalker! LOL!
- 05:27
- StampinCathy said...
Great take on this challenge. Don't feel so bad, I always have a list of things to do and it seems like I add more on it then take off of it.
- 05:39
- Deborah Saaranen said...
What a fantastic scene! Reminds me of the beach with the sun setting~!
- 05:49
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When the Morenos awoke the next morning, they couldn't believe the devastation. The river had crushed homes and barns and pushed everything down into the river basin. Refrigerators sat perched in trees. Kitchen towels hung from tree limbs. Wagons and farm equipment were upended.
The Ranneys' ranch was under six feet of water.
No one in Prado proper had died, but several bodies were pulled from the muck on the outskirts. Neil Lillibridge's mother got the news that her maid, who lived downstream, had drowned.
One of the eeriest signs that morning-after was the absence of livestock. Many were found under layers of mud. Others were washed miles downstream.
"One horse was dug out of the mud still alive near Huntington Beach, 35 miles downstream," Ranney wrote in a journal.


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WHILE Scotland's interest in Olympic football this year will be marginal due to the Scottish FA's refusal to become involved, the same can't be said for the Paralympics.
Scotland has several members in the GB cerebral palsy football squad.
Indeed, obscured behind wall-to-wall hype over Britain's Olympic prospects, Scotland seems certain to make a significant impact on the overall GB Paralympic squad – perhaps as high as 10%, and significantly higher than that in the 12-strong CP football squad.
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Scotland finished fifth in the last European championships, and sixth at the world championships in Holland last year behind five full-time squads (Iran, Brazil, Holland, Ukraine, and Russia). Behind Scotland were England, Ireland, USA, and Spain. Several of that Scottish team are now in the GB Paralympic squad.
Gordon McCormack, chairman of Scottish Disability Sport, is coy about numbers, but Scotland hopes to match the four CP players who went to the Beijing Paralympics.
"If we get four in the team we'd be ecstatic – five we'd be jumping and singing," said Glasgow-based McCormack, who is bullish about numbers in overall contention. "Our target for London was between 6 and 7% of the whole team," he said, "yet now we are wondering whether we might even make 10%."
There were 16 Paralympic Scots in Beijing, against 31 at the Olympics. This time it looks like being close to parity.
That's one type of equality which disability sport would relish, but ongoing debate over an integrated single Games for disability and mainstream seems frankly crazy. Paralympic sport would be even more marginalised if it were staged at the same time as the Olympics. The logistics and cost of hosting an additional 4000-plus competitors concurrently with some 10,500 at the Olympics would surely deter bidders and lead to longer Games, the curtailment of events in both categories, and lower numbers and fewer disciplines.
When the issue arose in December, Baroness Tanni Grey-Thompson was unequivocally against a merger. Britain's most successful Paralympian, with 11 gold medals, said the Para event would "disappear off the face of the earth. That way we wouldn't have an opportunity to showcase the vast majority of sports like we do now. There is not a city in the world that could host a Games the size of the two combined".
Controversy was rekindled last month when a BBC poll of 10,294 respondents across 19 nations found 47% in favour of integrating the two events, with just 43% for a separate Paralympics. Eight countries wanted to merge, six favoured holding them separately, with five divided. Predictably, major medal-winning nations were opposed: China 67% separate, 27% integrated; USA 64%, 29%; Australia 54%, 42%; UK 50%, 46.
Both McCormack and Gavin Macleod, CEO of Scottish Disability Sport, are in no doubt that a separate Paralympics is preferable.
"Certain disability groups would be marginalised," says McCormack. He has been a key figure in the battle to have athletes with learning difficulties restored to the Paralympic programme after a 12-year absence. "In Rio, in 2016, we hope there will be an even wider and more open programme. But with a single integrated Games, numbers would diminish. Would there be a place for dwarves? Would spina bifida be marginalised? Every potential host city would certainly be terrified by the cost."
There is also the fact that thus far the Olympics have hogged the media agenda – though Channel 4 can be proud of breaking the mould of TV coverage. However, with a single Games, and a single host broadcaster, this would almost certainly not have happened.
"With a separate Paralympics, come the Olympic closing ceremony, hopefully it will then be our time," adds McCormack.
Teams have yet to be named, but among the principle contenders are Libby Clegg, the visually impaired sprinter from Newcastleton. The Borderer won Paralympic 100m silver in Beijing, and 100m gold and 200m bronze at the IPC World Championships last year in New Zealand. A family double is a possibility. Her younger brother Jamie, who suffers from the same degenerative eye condition, is in contention for the swimming team.
The shape of that squad will be clearer after the three-day International Disability Event which starts in Sheffield on Friday. Fifer Craig Rodgie has already achieved the qualifying mark, but Jamie is among at least six other Scots very close to the required qualifying performances. Scotland boasts several other contenders: visually impaired cyclists Neil Fachie and Aileen McGlynn. Fachie, from Aberdeen, was a Paralympic sprinter four years ago, but has switched to track cycling, while McGlynn, double Beijing gold medallist from Glasgow, is aiming for her third Paralympics.
Hamilton's Stephen McGuire is ranked No.3 in the world in boccia. He is a double world silver medallist, and leads the British BC4 team, including his brother, at the BT Paralympic World Cup next month in Manchester. Britain boasts athletes ranked first, and two ranked second, in various boccia classifications.
Scotland also has one player in the GB wheelchair rugby squad – making its debut four years ahead of rugby sevens in 2016. Mike Kerr, from Uddingston, is in the pool for the two-day Olympic test event on April 18 and 19.
With the Paralympics so strongly embedded, it is hard, or desirable, to see a merger. As Gavin Macleod says: "Access and transport issues would also be exacerbated. On the other hand, disability sport will be part of an integrated programme at the 2014 Commonwealth Games in Glasgow."
That will inevitably colour perceptions on disability.
"Seeing our own athletes as part of a Scotland team alongside mainstream sportsmen and women will make a big difference," he adds.
Hopefully, when it comes to signing sponsors, Glasgow 2014 will remember the Olympic lesson. One wheelchair user complained during the ticketing process for 2012 that he could not buy any, because they had to be paid for with the credit card of an Olympic sponsor. He could not obtain such a card because he was in receipt of disability benefit.


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Ca2+-activated K+ channels of large conductance (MaxiK or BK channels) control a large variety of physiological processes, including smooth muscle tone, neurosecretion, and hearing. Despite being coded by a single gene (Slowpoke), the diversity of MaxiK channels is great. Regulatory b-subunits, splicing, and metabolic regulation create this diversity fundamental to the adequate function of many tissues.
Ca2+ entry into cells mediated by voltage-dependent Ca2+ channels (VDCCs) is essential for life because it permits, for example, neurosecretion to occur, smooth muscle contraction to take place, and the process of hearing to develop. However, some mechanisms must be put into action to control Ca2+ influx, either to stop or to dampen the physiological effect of the increase in cytoplasmic Ca2+. In many cases, this is accomplished by one of the most broadly expressed K+ channels in mammals: the large-conductance, voltage- and Ca2+-activated K+ channel, also known as the MaxiK (or BK) channel because of its large single-channel conductance (>200 pS in 100 mM symmetrical K+). This channel increases its activity on membrane depolarization or an increase in cytosolic Ca2+, and its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. Except in heart myocytes, MaxiK channels are almost ubiquitously expressed among mammalian tissues, and they play a variety of roles, of which only a few have been extensively studied.
Depending on the cell type, different MaxiK currents can be observed, differing mainly in Ca2+ sensitivity and macroscopic kinetics. Moreover, inactivating MaxiK currents have been observed. This variety of MaxiK channel types became intriguing when it was realized that there is only one mammalian gene, called Slowpoke (Slo) (8), coding for the MaxiK channel protein. This suggested that MaxiK channel diversity was a consequence of alternative splicing and/or interaction with regulatory subunits. In fact, both mechanisms account for MaxiK variability, but the interaction with a special kind of regulatory subunit is what causes the most dramatic changes in MaxiK properties. These are membrane-integral proteins called MaxiK β-subunits (7). Also, other regulatory proteins, posttranslational metabolic regulation, and modifications add more variety to this multifaceted channel (8).
Until 1999, only one β-subunit was known at the molecular level. This subunit (now known as the β1-subunit) accounted mainly for MaxiK properties in vascular smooth muscle cells (VSMCs), where it is highly expressed. In the past few years, three more β-subunits have been cloned and characterized. Here we will review and discuss this and other recent landmarks regarding the regulation of MaxiK channels by β-subunits and their physiological importance.
Molecular properties of MaxiK channels
The minimal molecular component necessary and sufficient for MaxiK activity is its pore-formingα-subunit, and functional channels are formed as tetramers of this protein. First cloned from Drosophila, the gene coding for MaxiK was called Slowpoke or Slo, and after the description of the Slo2 and Slo3 channels (see below) it was renamed Slo1. The presence of a positively charged fourth transmembrane segment makes the MaxiK channel a member of the S4 superfamily. Most members of this superfamily have six transmembrane segments, called S1 to S6, but MaxiK channels have a seventh transmembrane segment at the NH2 terminus, called S0. Thus the NH2 terminus of the protein is placed in the extracellular side of the membrane (Fig. 1⇓). The intracellular COOH-terminal domain comprises two-thirds of the protein and contains four hydrophobic segments and several alternative splicing sites (Fig. 1⇓).
The pore domain of the channel is assigned to the region contained between S5 and S6 segments, which includes the signature sequence of K+ channels (TVGYG). As in all other voltage-dependent K+ channels, the S4 segment is (or is part of) an intrinsic voltage sensor, which is the actual trigger for MaxiK activation (8). Gating and ionic currents in MaxiK channels can be elicited by membrane depolarization in the absence of Ca2+, suggesting that this is a voltage-dependent channel. The divalent cation acts as a modulator able to decrease the necessary energy to open the channel, as can be inferred from the leftward shift in the open probability vs. voltage (Po-V) relationships (Fig. 2⇓).
Recently, a tetramerization domain has been identified for the MaxiK channel in a hydrophilic region located between the S6 and S7 hydrophobic segments (10). This is the only hydrophilic region capable of self-association, forming stable tetramers in solution. In functional assays with truncated channels, this domain proved to be necessary for a dominant-negative feature, suggesting its involvement in tetramerization. This region was named BK-T1, resembling the T1 domain of voltage-dependent K+ channels, which is also involved in tetramerization. However, these domains are different both in amino acid sequence and localization.
The region from the S8-S9 linker to the end of the protein is called the "tail" and can be expressed as a separable domain. Its coexpression with the rest of the channel (the "core") produces functional channels, whereas neither of the parts alone forms functional channels. The Ca2+-binding site has been located to this large intracellular domain, between the hydrophobic segments S9 and S10 (8). This region, frequently called the "Ca2+ bowl" (Fig. 1⇑), is highly conserved in all cloned MaxiK channels and contains an Asp-rich (-QDDDDDP-) sequence motif, emerging as a very good candidate for a Ca2+-binding site. A study using chimerical channels between Slo1 and Slo3 confirmed the localization of the Ca2+ sensitivity to a region comprising the end of the S9-S10 linker and part of the S10 hydrophobic segment (13). On the other hand, direct 45Ca2+-binding studies were performed by using a fusion protein consisting of the last 280 amino acid residues of the Drosophila Slo1 (dSlo1) channel in an overlay assay (1). By replacing all Asp residues with the uncharged residue Asn, they showed that the Ca2+ bowl motif accounts for only 56% of 45Ca2+ binding. This implies the existence of more than one Ca2+-binding site per tail domain: a low-affinity and a high-affinity site (the latter being the Ca2+ bowl).
The Slo family
The MaxiK channel is not the only member of its family. Another two members have been described: Slo2 and Slo3 (12, 20). The Slo2 gene was cloned from the worm Caenorhabditis elegans, and Slo3 was identified from a testis cDNA library.
Slo2 needs the presence of internal Cl− to be activated by Ca2+, and the sensitivity to these two ions is strictly coupled. Slo2 lacks a S0 domain and an apparent intrinsic voltage sensor since the S4 domain is uncharged (Fig. 1⇑). Surprisingly, Slo2 is a voltage-dependent channel, albeit with a smaller voltage dependence than Slo1. The Slo2 gene has a mammalian ortholog called Slack.
Slo3 shares the same membrane topology with Slo1 and is also voltage dependent. However, Slo3 is regulated by intracellular pH instead of internal Ca2+; increasing pH increases Po.
Sources of MaxiK channel diversity
It is not only changes in membrane potential and Ca2+ concentration that result in modulation of MaxiK channel activity. There is evidence of changes in MaxiK channel activity by phosphorylation and/or interaction by G proteins, by mechanical stretch, and by various endothelium-derived vasoactive substances (8, 17). All of these modulatory mechanisms allow fast integration of multiple stimuli in many tissues, including neurons, VSMCs, and cochlear hair cells. The Drosophilaα-subunit (dSlo) can interact with two different accessory proteins, known as dSlip1 and Slob. Both are soluble proteins that can physically interact with MaxiK channel by its intracellular face. Whereas Slob increases the channel Po, dSlip1 seems to decrease the number of MaxiK channels in the plasma membrane.
Alternative splicing creates channels with different kinetics and Ca2+ sensitivity. Most splicing sites are located in the COOH terminus of the Slo1 protein, and several sites reside between hydrophobic domains S8 and S9 (8). However, the differences between splice variants are modest when compared with the effect of coexpression with β-subunits. It is the interaction with these accessory proteins that creates really different MaxiK channels, which, with the other regulatory mechanisms, can be finely tuned to perform their physiological roles.
The β-subunits
Regulatory β-subunits share a putative membrane topology, with two transmembrane segments connected by a 120-residue extracellular "loop" and with NH2 and COOH terminals oriented toward the cytoplasm (Fig. 1⇑). The loop has three or four putative glycosylation sites. At present, four β-subunits have been cloned in mammals (2, 7, 9, 15, 18).
Sequence similarities are major between β1-β2 and β2-β3, respectively. β4 is the most distantly related of all β-subunits. β-Subunit orthologs have not been described in Drosophila or in the worm C. elegans, suggesting that this protein is a "novel" acquisition in evolution.
The first β-subunit was identified as a protein associated with MaxiK channels in smooth muscle membrane preparation with high affinity for charybdotoxin (CTX), a MaxiK peptide blocker. This protein was called β-subunit, but with the recent cloning of new family members, it was renamed β1. Coexpression of this subunit with theα-subunit produces a leftward shift of the Po-V curves, an effect that it is particularly dramatic at Ca2+ concentrations > 1 μM. However, functional coupling betweenα- and β-subunits can take place in the absence of Ca2+ (4). In this condition, the β1-subunit increases Po, but because of its low magnitude this change is almost imperceptible in macroscopic records. The primary effect of the β1-subunit is to increase the stability of the open states, although small changes in Ca2+ affinity of both closed and open states appear to be functionally important (4). Besides increasing the apparent Ca2+/voltage sensitivity of theα-subunit, the β-subunit also modifies MaxiK channel kinetics and alters its pharmacological properties. The β-subunit slows down the activation and the deactivation kinetics of the channel (Fig. 2⇑). The presence of the β-subunit is also a requirement for internal binding of the MaxiK channel opener dehydrosoyasaponin (a triterpene glycoside) (17) and for external binding of the agonist 17β-estradiol (16).
The next cloned β-subunit was identified by searching homologues to the β1-subunit in human expressed sequence tag (EST) databases. This new subunit is expressed preferentially in chromaffin cells and brain and was dubbed β2 (18). The most notorious difference from the β1-subunit is an NH2-terminal domain that contains a hydrophobic region followed by positively charged residues. This type of sequence is characteristic of inactivation peptides that can occlude the conduction pathway of Shaker K+ and of MaxiK channels. Consequently, coexpression ofα- and β2-subunits produces inactivating currents, such as those seen in some chromaffin cells (see below). Removal of the NH2-terminal domain, either by trypsin or molecular biology techniques, results in a β-subunit that does not inactivate the channel, so the currents are sustained and more suitable for kinetic and Ca2+ sensitivity comparisons. Ca2+ sensitivity and gating kinetics of channels formed byα- and β2-subunits are similar to those of channels formed byα- and β1-subunits (18). In contrast to the β1 subunit, this subunit confers low CTX affinity compared with channels formed only byα-subunits (18).
The β3-subunit was cloned from human EST databases. It was detected in testis, pancreas, and spleen (19), and it is phylogenetically more related to β2 than to β1 (15). There are four splice variants (β3a–d), whose differences are in the NH2-terminal region. Each splice variant confers different inactivation properties to the MaxiK channel. Whereas the β3a and β3c subunits confer similar inactivation properties, β3b induces a faster and incomplete inactivation process that becomes evident only at large depolarizations (19). It is unclear whether or not the β3d-subunit interacts with theα-subunit since coexpression ofα- and β3d-subunits does not produce changes in the Ca2+ activation curves or in the gating kinetics of the MaxiK channel.
The β4-subunit, also cloned from human EST databases, is expressed mainly in brain. Its coexpression with theα-subunit decreases the apparent Ca2+ sensitivity of the MaxiK channel (2, 9). Although this subunit slows down channel activation kinetics in a manner similar to the β1-subunit, the deactivation kinetics is very fast (similar to that observed in absence of the β-subunit; see Fig. 2⇑) (2). These results indicate that the functional coupling of this subunit with theα-subunit is different from that induced by the other β-subunits. The β4-subunit decreases the CTX binding strength. If the external loops of the β1- and β4-subunits are exchanged (chimeras β1Lβ4 and β4Lβ1), the phenotypes obtained regarding toxin binding correspond to their respective loops (e.g., chimera β1Lβ4 has a toxin sensitivity corresponding to the β4 subunit). These results suggest that the loops of the β-subunits determine the characteristic of toxin binding. Also, because CTX is a pore-blocking toxin, it is suggested that the extracellular loop of β-subunits (at least β1 and β4) faces the pore and is very close to it (9).
β-Subunits therefore alter the Ca2+ sensitivity and gating kinetics of MaxiK channels, greatly contributing to MaxiK channel diversity. On the other hand, they modify the MaxiK channel pharmacological properties, changing toxin binding and acting as receptors for drugs. Most importantly, they allow the MaxiK channel to play important physiological roles, as we will see below.
Physiological role of β-subunits
In most native cells, MaxiK channels are functionally coupled to VDCC, an association that makes MaxiK channels function as negative feedback for VDCC activation and Ca2+ entry into the cell. VDCC activation leads to inward Ca2+ currents, which then promote membrane depolarization and accumulation of intracellular Ca2+. Both events then promote MaxiK channel activation, leading to a hyperpolarization that closes VDCC.
To have a significant effect on MaxiK channel activity, intracellular Ca2+ concentrations must be >10 μM. Those elevated intracellular Ca2+ concentrations can indeed be reached in small "compartments" inside the cells, the Ca2+ microdomains, where VDCC and MaxiK channels are often tightly colocalized. Space and time characteristics of such compartments depend on the entry and exit of diffusing free Ca2+ and Ca2+ buffer properties (binding rate, mobility, etc.).
Not only VDCCs from the cell membrane are coupled with MaxiK channels. Ryanodine receptors from the sarcoplasmic reticulum are very close (<20 nm) to MaxiK channels in the plasma membrane. This association, confirmed by structural and functional evidence, is the basis for the proposed role of MaxiK channels in the control of vascular smooth muscle contraction. Below we discuss the negative feedback imposed by MaxiK channels in smooth muscle, chromaffin cells, and cochlea.
Smooth muscle
In VSMC, MaxiK channels provide the adequate regulation of the contractile tone. Local Ca2+ increases, called Ca2+ sparks, generate spontaneous transient outward currents (STOCs), which are generated by MaxiK channels. This hyperpolarizes the membrane and promotes relaxation (discussed in Ref. 6). As mentioned earlier, in these cells highly Ca2+-sensitive MaxiK channels are formed mostly byα- and β1-subunits. The physiological relevance of β1-subunits in modulating the Ca2+ sensitivity of the MaxiK channel was shown with β1 knockout mice (3). The cerebral artery myocytes of these mice exhibited a decrease in the Ca2+ sensitivity of the MaxiK channels and a low Ca2+ spark-STOC coupling (Fig. 3⇓). The absence of the β1-subunit also promoted an increment in arterial tone and blood pressure.
Chromaffin cells
Adrenal chromaffin cells are excitable cells that release neurotransmitters such as catecholamines in response to electrical stimulation. In these cells, MaxiK channels are important for the rapid termination of the action potential. Even though four different subtypes of VDCC (L, N, P, and Q types) are found in these cells, MaxiK channels are functionally coupled only to L- or Q-type VDCC. In rat chromaffin cells, there is a cell population that has inactivating MaxiK currents (MaxiKi) and a population with noninactivating MaxiK currents (MaxiKs) (17). In the MaxiKi cells, the β2-subunit is expressed. As a consequence, MaxiK channels in these cells show rapid inactivation and slow deactivation kinetics (18). Because of the much slower deactivation of the MaxiK channel, the afterhyperpolarization phase is prolonged. This relieves Na+ channel inactivation and allows repetitive firing. Thus while MaxiKi are tonically firing cells, MaxiKs are phasically firing cells (Fig. 3⇑) (14).
In the frog, chick, and turtle auditory systems, which have been used as models of study of this sense, frequency tuning is performed almost exclusively by the hair cells. Each different hair cell has a characteristic tuning frequency. In these animals, electrical resonance is achieved through the interplay of L-type VDCC and MaxiK channels operating, as for example in the turtle, at frequencies from 30 to 600 Hz (5). The opening of L-type VDCC induced by depolarization increases internal Ca2+ concentration, which in turn activates MaxiK channels. Activation of MaxiK channels hyperpolarizes the cell, closing Ca2+ channels and promoting the membrane potential oscillation. Subsequent oscillations are damped, because fewer MaxiK channels are recruited in each cycle (Fig. 3⇑) (5). The number and type of MaxiK channels control the resonant frequency of a particular hair cell. Higher frequencies are present in cells containing a large number of MaxiK channels with faster activation kinetics. The origin of this wide range of MaxiK gating kinetics is not completely clear at present but most probably is accomplished by differential expression of distinct splice variants of the Slo1α-subunit, together with an expression gradient of a β-subunit (5, 11). In fact, a number of MaxiK channel splice variants with different activation kinetics and Ca2+ sensitivities have been identified in different places in the cochlea (5). In chicken, an ortholog of the β1-subunit that presents an expression gradient across the cochlea has been identified (11). As mentioned earlier in this review, the β1-subunit increases Ca2+ sensitivity and slow deactivation kinetics. β-Subunits add to the system a level of variability that cannot be achieved only with a splice variant expression gradient. It is of interest to note here that, as the frequency range gets wider, more diversity in the MaxiK channel is needed. Thus Fettiplace and Fuch (5) modeled the electrical tuning in the turtle with five MaxiK splice variants, but in the chicken basilar papilla (150–4,000 Hz), they needed a minimum of nine MaxiK splice variants.
In this review, we have tried to convey to the physiologist the importance of a voltage-dependent K+ channel with a probability of opening also controlled by cytoplasmic Ca2+. This tetrameric channel, formed by a protein coded by a single gene (Slowpoke), attains its large diversity essentially through three mechanisms: alternative splicing, metabolic modulation, and forming a molecular complex with β-subunits (β1–β4). Of course, one or more of the above-mentioned mechanisms acting at the same time can also obtain more multiplicity of MaxiK channels. In particular, the biophysical properties of MaxiK channels are drastically modified by the most studied and well-characterized β1-subunit. This subunit, by decreasing the energy necessary to open the channel and by slowing down channel deactivation, sets the tone in smooth muscle (a fact firmly demonstrated with the help of β1-subunit knockout mice). Extraordinary in its beauty is the molecular mechanism used by turtles, frogs, and chicks to generate in the cochlea the fundamental resonance frequencies. In those animals, gradients of spliced MaxiK channels and β1-subunits across the cochlear epithelia talk to VDCC to produce the different oscillatory voltage responses in the hair cells.
As we discussed, in many tissues the physiological role for β2-, β3-, and β4-subunits can be inferred from the impact of these subunits in the electrophysiology of the channel. However, the real physiological impact will not be known until more detailed studies in native cells are undertaken. For example, the β3-subunit has been detected in testis, but native MaxiK currents in this tissue have not been described in detail. The implication of β2- and β3-subunits in spleen and pancreas, where β3 is located at secreting β-cells (15), is also not clear. In these cells, macroscopic MaxiK currents have been described, but their physiological role remains obscure. We are confident that all of the present unknowns regarding this field will be understood in the near future, unveiling new mechanisms of how the electrical activity of the cell is coupled to its metabolism.
We are supported by Fondecyt Grants 1000890 (R. Latorre), 2000061 (P. Orio), and 2010006 (P. Rojas); TWAS-99-301 RG/BIO/LA (G. Ferreria); Human Frontiers in Science Program (R. Latorre); and Cátedra Presidencial (R. Latorre). P. Orio is recipient of a Ph.D. fellowship from Fundación Andes. P. Rojas is recipient of a Ph.D. fellowship from Conicyt. CECS is a Millennium Institute. CECS also benefits from generous support by Empresas CMPC.
- © 2002 Int. Union Physiol. Sci./Am.Physiol. Soc.


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Family is always a beautiful source of comfort. But sometimes, when all the generations have gathered, it's even more. It's a testament to humanity's endless love and caring, and a vision of a happy future.


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Calum Chambers' first Arsenal interview [video]
Calum Chambers gave his first interview on signing for Arsenal and seemed delighted with his move from Southampton.
The versatile defensive player said it was "amazing" to join Arsenal and paid tribute to Arsene Wenger and the fact young players do get opportunities at the Emirates.
Chambers comes across as a grounded 19-year-old, simply enjoying a big money move that makes him Arsenal's third most expensive player after Mesut Ozil and Alexis Sanchez.
Wenger has spoken of Chambers as a player that can appear at right back, centre back and in midfield.
Reports suggest Chambers has been guaranteed around 20 matches in the Arsenal first team this season.