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My Nonprofit Reviews
Review for Extras for Creative Reuse Inc., Lynn, MA, USA
ExCL is an amazing place that helps teachers in a great way! I work with adults with developmental delays and we go to ExCL once a week and the staff is extremely friendly and welcome to both myself and my clients. They always have a task for us to do and great feedback to go with it once the task is done. They always thank us up and down for the work that we do, but if it was not for organizations like this one our program would not be the community based one we are. This organization has welcomed us with opened arms and has always had the door open for us to volunteer. The staff is extremely friendly and interacts with my clients in such a positive manor, it is so refreshing to see. They work so hard to make sure things are as organized as possible and take pride in what they are accomplishing for others. I am happy to say that I volunteer for such an organization!
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Having practiced for 35 years, I have seen quite an evolution of the profession of podiatry. There have always seemed to be many "crises" on the horizon. Despite this, our profession has moved on and survived.
Today, practicing as a podiatrist, you see many problems, not all of which require surgical intervention. Also with the decrease in reimbursements and the rising cost of malpractice insurance, one must consider how much surgery you choose to perform. It may be interesting to listen to presentations of some "exotic procedures" at a seminar but in reality, not many podiatrists see them in the average practice.
Requiring a three-year residency may seem to elevate our profession but if there are "78 more applications for residencies than there are slots available," what are those 78 graduates to do? If they have been able to do well enough to obtain a DPM, is it fair to not allow them to practice because there are not enough residencies available? Who would want to enter a profession where you could achieve four years of education, a degree and amass a considerable debt, but not be able to practice your profession? This doesn't sound like a good gamble to me.
Not all podiatrists can be great surgeons but you can obtain great satisfaction from helping people to feel and function better. Over 35 years, I have treated many patients - the frightened child, the weekend warrior, the everyday worker, the nursing home resident and enjoyed all of it. Having someone leave the office after a "minor procedure" and say "Doc, that feels much better" is satisfaction that you receive everyday. You can't say that about every job.
I only hope that those graduating today and in the future (whether or not there is a 3-year residency requirement) can enjoy their years of practice as much as I have and continue to do everyday.

subset: commoncrawl


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Once I've opened the samples from Life in Teacup, I've been storing them in odd, empty tins. This one's in Andrew and Dunham's Earl Grey tin (I haven't removed the label or anything—this is just temporary).
Dried, the smell of the leaves is a fainter 'tea leaf' smell, which is also somewhat sweet. I like it.
First steep I ended up doing twenty seconds instead of ten (didn't use quite as many leaves—about two very rough teaspoons [the leaves are a fair size and don't fit in my teaspoon very well], to six ounces water; also did a rinse-steep prior to the first steep). I'm not getting any smell from the tea. Hmm.
It has a darker oolong taste, I guess. I'm bad at explaining these things, especially since I haven't tried many. It's lighter than say Honeybee, but darker than ti kuan yin. However, it's floral and sweet. In fact, the sweetness is kind of fruity almost, but without any tart. I suppose this is what people mean when they use fruits to describe teas. Maybe peach? I'm glad I got up early, this means I can experience a few more infusions before I leave for class.
This is VERY nice to sip. The sweetness sits as an aftertaste on your tongue for a bit.
Second steep, did thirty seconds. There's definitely a sort of nectar-sweet quality, so definitely sticking with 'peaches'. And possibly something else, but I can't really place it.
Third steep, did a minute. Since I let the leaves sit overnight, this may be the reason I'm getting pretty much no flavour at all. Huh.


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Timmy's Basement Babe of the Night! – Alexa Vega
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Sure she saved the world a couple of times in the Spy Kids movies, but she's grown up and is hot now, not to mention metal bra and kickin' ass in the upcoming movie Machete Kills! Get your hairballs now in the KAT HOUSE for Timmy's Basement Babe for Wednesday (7/10), Alexa Vega!


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your welcome everybody!I love making people happy!Hope you think my other puzzles are just as cute!
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4.30 Ffos Las
Given his overall profile of late, AGERZAM (best price 11-1) is clearly not one for maximum stakes, but he showed enough at Bath last time out to suggest he's not one to confine to the Dusty Bin (one for the old school brigade) just yet. Although he failed to land a meaningful blow in the race eventually won by Go Amber Go at the Somerset venue, Ron Harris' inmate was constantly denied a clear run throughout the entire five-furlong trip and even though it's difficult to say with any degree of certainty where he might have finished, it's probably a fair guess to suggest he would have been heavily involved in the outcome given how strong he went through the line.
Obviously, one swallow doesn't make a summer, but it should also be pointed out that the son of Holy Roman Emperor is racing off his lowest ever career mark and on the evidence of his latest performance, it wouldn't be the biggest shock in the world if he were to take advantage of such leniency sooner rather than later.
6.50 Chelmsford
CERTIFIED (best price 7-4) clocked a smart speed figure when keeping her unbeaten record intact at Wolverhampton last time and the hat trick looks well within her capabilities returning to the scene of her debut success back in November. On that occasion, James Tate's filly made quite an impression by staying on strongly late on justifying heavy market support and she had no problems in coping with the extra furlong when powering clear in the latter stages at the Dunstall Park venue two weeks ago. Hailing from a stable whose had five winners from their last eight runners, the daughter of Raven's Pass has the qualities to take this step up in grade within her stride.


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A 29-year-old man died following a stabbing outside a meat market in the unincorporated county area of South Whittier late Friday, authorities said.
Israel Lopez, of Whittier, died at 7:56 p.m. at UCI Medical Center, according to Orange County coroner's officials.
The fatal stabbing took place shortly after 7 p.m. in front of a meat market in the 11800 block of Carmenita Road, just south of Meyer Road, Los Angeles County sheriff's officials said.
"Detectives have learned deputies from the Norwalk Sheriff's Station responded to the location regarding an assault with a deadly weapon call. Upon their arrival, they found the victim lying on the curb suffering from stab wounds," deputies from the Sheriff's Headquarters Bureau said in a written statement.
Lopez was taken to a hospital where he succumbed to his injuries, according to Deputy Guillermina Saldana.
No information regarding a suspect was available, and no further details were released.
Anyone with information was asked to contact the Sheriff's Homicide Bureau at 323-890-5500. Tips may also be submitted anonymously via L.A. Regional Crime Stoppers at 800-222-8477.


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- On the box
Reborn in the USA
The multi award-winning BBC show Top Gear is watched across the world but, as the presenters often comment, it's not widely shown in the USA for a variety of legal/taste reasons. But now a US version is halfway through a ten-show run and the jury is out on whether it is a success of not.
Audiences have been stable around the 1.2 million mark after attracting two million for the first show - a far cry from the 6.6 who tuned in for the BBC original's Christmas special on December 26 - although analysts are concerned it is failing to hold on viewers from the preceding programme.
Jane Tranter of BBC Worldwide, who are making the programmes on behalf of the History Channel, said: "Together we have worked to tailor the format for the American audience, while staying true to the original dynamic that fans across the world have come to love."
While wanting to ape what the BBC itself describes as the "laddish antics and irreverent humour are such a big part of its appeal" - many of the familiar features have been carried over, such as Star in a Reasonably Priced Car (renamed Big Star), and the Stig also makes appearances - producers have had to adapt for the local market, and that has met with a mixed response.
We asked our US-based readers on our Facebook page to give their opinion of the American version and the feedback was almost unanimously negative, with the biggest area of concern the three presenters, racing driver Tanner Foust, Speed channel reporter Rutledge Wood and comedian/actor Adam Ferrara.
"For those who have not seen the England version, it may be alright, but the dialogue between the US version guys is simply not entertaining or funny," one wrote, while another added: "No enthusiasm, forced, not funny, not imaginative, very scripted, sorry but it is horrible"
John Hesling, the show's producer
British-born, LA-based John Hesling, the show's producer, has defended his choice of the trio. "They got on with each other very, very well. There's that immediate kind of X Factor. These guys seem to chat like they've known each other for a long, long time. I don't see why you'd want a group of sort of bad-teethed Brits coming and telling you about your own car culture."
There have also been concerns expressed that the show is funded by advertising, largely from the motor industry, which they claim limit the amount of openness when reviewing or commenting on cars. Self-proclaimed car fanatic Jay Leno turned down an offer to front an earlier pilot for the NBC channel for this reason. "My great fear in America is that, for instance, if Kia was our sponsor this week, we'd have to say the car was fantastic," he wrote in the Sunday Times.
Actor and racing driver Bruno Massel, who ended up fronting the earlier NBC pilot, echoed those fears when he said: "You didn't want to insult anybody or put a product down, there was a concern about alienating the companies."
Producers can take heart from Australia, where a local version of the show was met with withering criticism when launched in 2008, but after making changes the programme has now completed three series and is attracting good audiences. However, a Russian Top Gear was scrapped after half a series in 2009.


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Burger Lovers
Burger Lovers
1466 W. 7th Ave.
Eugene, OR 97402
(541) 687-6424
If you regularly drive along 7th Ave, near Wells Fargo, you've probably noticed a new restaurant under construction for the last few months. Well, Mr. Eugenified finally took the plunge and gave it a try (after leaving the appropriate one month waiting period for them to serve all the "construction dust burgers" to other more gutsy patrons). The name of this place gives a pretty good idea of their goal: specialists in burgers. But their claim to be "the best burgers in Oregon" is certainly ambitious. So the question is: Are they good burgers, the best in Eugene, and/or the best in all of Oregon?
Unfortunately, before you can try one of these burgers, you'll need to find the place. And really, it's quite easy. First turn onto 7th Ave (one way) from, say, Garfield. Accelerate hard to bring your vehicle speed up to 88 miles per hour. Stay in the far right-hand lane, but watch out for those cute little aged-hippies who love to stick the nose of their Subarus into traffic to "test the water". Continue at 88 miles per hour in the right-hand lane and try to spot the first sandwich-board sign that says "Open"…that's not it. Look for the second sign that says "Now Open" with "Burger Lovers" in small print underneath. (No, you won't be able to read that line while traveling 88 miles per hour). OK, now here's the hard part: At just the right moment, flick the steering wheel to the right to start a Vin-Diesel-style power slide (I wonder what Vin's real name is? Probably something like Mortimer Snerd) while, this is the important part, keeping your foot firmly planted on the gas pedal. At just the right moment, slingshot into the Burger Lovers parking lot. Viola…You've done it! (Bring along a change of underwear, just in case).
OK, so the menu…It's as you would expect, a basic entry-level burger and then thirteen different variations on that basic burger. Topping choices among these thirteen variations include bacon, cheese, cream cheese, avocado, mushrooms, a fried egg, teriyaki sauce, pineapple, ham, BBQ sauce, double patties, corned beef, rat droppings, green chilies, etc. (Just checking if you're paying attention. They really don't offer rat droppings as a topping). They also have chicken sandwich, BLT, Rueben, and Po Boy choices on the menu. But we're here for burgers, so let's stick with that area for now.
Being a wily burger lover, I ordered a basic "Original Burger" rather than one of the fancy slathered-up sauced-down variations. My theory being that you first start with the basic burger to check the quality of the "foundation", only later moving on to check-out the "decorations".
Ordering at Burger Lovers is done at the front counter and is fairly straight-forward. The only thing out of the ordinary were the somewhat frenzied blue felt-tip pen markings on the overhead sign board. Things likes "cheese add $0.50" and "comes with fries" were forcefully circled in thick blue marker pen. Seems the front counter people are getting tired of answering the same dumb questions from dumb customers, so they decided to help the dumb customers out by adding the blue felt-tip pen circles and underlines of the answers to dumb questions. Thanks.
Also of note, the front counter person during my visit was named Agnes Bae, a nice Korean American lady who is the brains behind this operation. Actually, the owner of Burger Lovers is Agnes' sister, but Agnes supplied most of the strategic planning based on her 20 years of experience owning and operating similar restaurants in various cities around the US (I think she mentioned Portland, Oakland, and maybe LA). Notably, she also owned Jamie's Diner in Eugene (now called Terry's Diner, located at 18th and Chambers) for several years before selling the business.
But let's get to the core issue: How was the burger? Taste-wise, it was ok. Some charcoal flavor in the meat, not too fatty, and an ok bun. Maybe a little dry, but not bad. Condiments included somewhat thin slices of tomato and finely shredded lettuce. The burger came with fries (read the sign board where they have clearly marked this with blue felt-tip pen!), and they (the fries, not the staff) were somewhat thin-ish as well. I remember these previously were called shoestring potatoes at some point back in ancient times. They were slightly overcooked and perhaps had sat in the warming area a bit long. (I am guessing the overcooking may have come from them having been dropped back into the fryer for a quick re-warming…an old diner trick).
But clearly something was missing…a certain je ne sais quoi…then it came to me. Burger Lovers lacks sufficient chunkification. Nothing is chunky enough. Not the beef patties, not the bun, not the tomato slices, and certainly not the daintily shredded lettuce. Even the fries are too thin.
Admittedly, a de-chunkified burger is probably easier to eat. You can pick it up and take a reasonable bite without the whole thing falling apart, but…I still prefer the chunky version. Something about it just says "indulgence" or maybe "weight gain". Either way, that's the feeling I want in a gourmet burger and Burger Lovers does not deliver this feeling for me. Is it the best burger in Oregon or Eugene…uhhhh…no. For sure it's the best on that section of 7th ave. And that's better than nothing.


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Hollywood, CA--As the final week of competition on ABC's hit reality show "Dancing With the Stars" draws near, many fans have been heard to cry conspiracy in response to Bristol Palin's inexplicable staying power. The show's own professional blonde phenom, Derek Hough, confirms that there most definitely is a conspiracy brewing behind the show's sequined curtains, but it's far more diabolical than just a bass-ackwards way of making Sarah Palin president.
"I figure it's just time to come out with it, you know?" said the dancer in an interview Thursday. "I've spent three years on that show and it's time to get the ball rolling. A lot of people have told me that they just can't see this kind of thing coming from me, but that's just because the distractions I put in place worked so well." (Laughs lightheartedly)
Hough went on to state that he's been considering taking over the world for a long time, and that it's been a dream he's had since he began dancing.
"I really started to realize my true potential for what magicians call "misdirection" when I was fourteen. I began to dance for the security guards in front of a department store while some friends of mine walked out the front door with three carts full of merchandise. The guards didn't even notice what was going on because they were so mesmerized by my footwork. That's when I knew that anything was possible through the art of dancing, I just had to put my mind to it and think of a way to use my powers in a big way. So when I was asked to be a dancer on Dancing With the Stars, I knew what I had to do and jumped right on the opportunity."
The 25-year-old Utah native described how he secretly amassed power through unquestioning viewer loyalty during the progression of the show.
"The idea wasn't to win every season, but to create a following by broadcasting subliminal messages over the audio tracks of the songs my partner and I would dance to. Like I said, magicians call it misdirection. While people were focused on my hips doing one thing, they were completely unaware of what was happening in the background!" (Laughs) "It was all so perfect, and no one ever suspected me because I always made a point of being real obvious on camera. Whenever I was onscreen I would jump up and down or get a deer-in-the-headlights look on my face or suddenly pop into frame for no reason at all, and people would think I was just being goofy."
But just exactly how was Hough planning to use his zombie fanbase to blindside planet Earth? The answer, he says, is simple.
"Once Jennifer [Grey] and I win the competition, it'll finally be time to put the rest of my plan into action. When the season's over and we're making the rounds through the talk show circuit, I'll air all the advertisements for the products I'll be putting out. There'll be a little bit of everything on the market with the Derek Hough label, from cereal to energy drinks to Hough: the Fragrance For Men. I've even designed my own line of clothing based on the costumes I've worn on the show! Anyone who's seen me dance and heard the subliminal messages will be compelled to buy my products, and soon everyone will be walking around looking and even smelling like me!"
And once that happens, the dancer said, it's only a matter of time until people are susceptible to his every command.
"I haven't actually thought about what I'm going to do with the world once it's mine, but it will probably involve dancing." (Shrugs)
When asked if he was worried that revealing the details of his plan like a James Bond villain would alert the population, he just smiled wide and reminded us of the method in which he'll dominate the world in the first place.
"People can't take their eyes off me when I dance, even if they don't like me. I mean seriously, a few months ago I demolished an entire house just by dancing in it. How could anyone doubt my power?"
And how exactly does Bristol Palin fit into all of this?
"Bristol is just another part of the misdirection. While everyone is worried that she's going to win Dancing With the Stars via some nationwide network of ultra-conservative, Palin-For-President Tea Party-Goers e-mailing each other to vote for Bristol, I'm making sure that the millions of people who tune in every week hear my subliminal messages and buy my products. I mean come on, I am a choreographer after all!"


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More people purchased Bull's Facebook anthem than pirated, the rapper says, despite the track being readily available on torrent sites.
Dan Bull is on a mission to "hijack the pop charts."
Best known for his Skyrim single, which has received more than 4.6 million YouTube views, the U.K. rapper took an untraditional route for releasing his latest track, "Sharing is Caring"—ButTorrent sites. And more importantly, the tactic worked.
Through promotion on YouTube, Reddit, and the Pirate Bay, Bull said more people paid to download the song from his site, where it was available for $0.89, than pirated the track.
"For me, The Pirate Bay has got me thousands of new fans – paying fans – overnight," Bull told the Daily Dot.
The Pirate Bay has has been featuring unknown artists, like Bull, on its homepage since the launch of "The Promo Bay" a few weeks back.
"I don't have access to reliable sales figures unfortunately, but I know that more people clicked the store links to buy it than clicked on the link to the torrent, despite both being equally accessible from my website," Bull added. "A good proportion of people clicked on both the link to the torrent, and then went and bought it anyway."
But while taking advantage of free distribution channels certainly gives musicians a better chance of getting heard than mailing demo tapes to record labels, can this model really sustain profits for musicians? Bull would argue that people are more willing to purchase tracks when they know the money is going straight to the artist.
"I don't believe in the common perception of pirates as criminals and freeloaders," Bull said.
"Many pirates are music lovers who feel ostracized by the mainstream media and record industry and so resort to other ways of consuming. I would have been more surprised if people only downloaded the free version."
While the Pirate Bay's of bands like Toggi, which are currently featured on the homepage, certainly helps, it just got a lot trickier. Pirate Bay was blocked in the U.K. this week at the behest of the British Phonographic Industry, and Bull said it did much more harm to musicians than good.
"The bitter irony (is) that in the week that a website has helped an unsigned musician hit the charts with a song called 'Sharing Is Caring,' that the BPI has succeeded in censoring that same website, based on the claim that 'sharing is killing.' The BPI have done this in the name of musicians like me, without our input or approval. I wish they would just admit that they aren't a compassionate, charitable organization who just want to make the playing field fair for musicians, but rather their single goal is retaining absolute control over the means of distributing music."
But Bull says even sweeping moves like this can't bring a halt to filesharing.
"Although the block of the Pirate Bay in the UK is very sad indeed, it's actually laughable in terms of how ineffective it will be at stopping filesharing," he concluded. "Filesharing will only continue to get easier."
Photo by Dan Bull
Pure, uncut internet. Straight to your inbox.


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This collection by Pari Jewellery includes trendy chic jewellery with a touch of authenticity. You can wear them on some special occasions or party to create a new style statement. From the past trends, jewellery has been synonymous with something that is precious and heavy. The Pari infused a new age spirit into this whole concept by introducing in the Indian market, sophisticated and light fashion jewellery. The USP of the brand is that it offers breathtaking designer accessories at brilliant quality.
The images represent actual product though color of the image and product may slightly differ.


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James Trimmer, Ph.D.
1163 Life Sciences
Davis Campus
As neuroscience enters the post-genomic era, a major goal is the translation of genomic sequence information into a molecular understanding of the mechanisms of neuronal information processing and transfer. My laboratory's research focuses on protein function, biochemical pathways and networks of protein-protein interactions regulating intra- and inter-cellular signaling in mammalian neurons. In particular, we are interested in dynamic regulation of voltage-sensitive ion channel abundance, localization and function through reversible protein phosphorylation. These proteins determine the intrinsic electrical properties of neurons and how these cells respond to external stimuli, integrate the encoded information and generate an appropriate response. Modern proteomic techniques have allowed for insights into protein networks, and post-translational modifications, that provide for both the generation and maintenance of complex cellular functions, but also their dynamic regulation that underlies functional plasticity. Our studies are aimed at a molecular understanding of how neuronal ion channels generate and maintain the fidelity of neuronal signaling, and how these processes can be dynamically regulated to generate neuronal plasticity. Such information is necessary for an increased understanding of not only the normal functional plasticity of neurons, but also in understanding of disease states where neuronal function is altered and effects of acute external insults such as ischemia and drugs of abuse, and represent a key step towards the development of therapeutics that can address these and other psychiatric and neurological disorders. Moreover, these studies are representative of approaches that would prove advantageous to studies on other neuronal signaling proteins. To better translate findings from genome-based studies, we have also established the UC Davis/NIH NeuroMab facility, to use information on proteins encoded in the human and other genomes to generate monoclonal antibodies for use in the research community.
Kirk, L. M., Ti, S. W., Bishop, H. I., Orozco-Llamas, M., Pham, M., Trimmer, J. S., Díaz, E. (2016). Distribution of the SynDIG4/Proline-Rich Transmembrane Protein 1 in Rat Brain. J. Comp. Neurol. 524:2266-2280. PMID: 26660156.
Alexander, S. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Catterall, W. A., Cidlowski, J. A., Davenport, A. P., Fabbro, D., Fan, G., McGrath, J. C., Spedding, M., Davies, J. A.; CGTP Collaborators. (2015). The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br. J. Pharmacol. 172:5729-5743. PMID: 26650438.
Gong, B., Murray, K. D., and J. S. Trimmer. (2015). Developing High-Quality Mouse Monoclonal Antibodies for Neuroscience Research – Approaches, Perspectives and Opportunities. New Biotech. 33:551-564. PMID: 26644354.
Cobb, M. M., Austin, D. C., Sack, J. T., and J. S. Trimmer. (2015). Cell Cycle-Dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells. J. Biol. Chem. 290:29189-29201. PMID: 26442584.
Bishop, H. I., Guan, D., Bocksteins, E., Parajuli, L., Murray, K. D., Cobb, M. M., Misonou, H., Zito, K., Foehring, R. C., and J. S. Trimmer. (2015). Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons. J. Neurosci. 35:14922-14942. PMID: 26538660.
Thiffault, I., Speca, D. J., Austin, D. C., Cobb, M. M., Eum, K. S., Safina, N. P., Grote, L., Farrow, E. G., Miller, N., Soden, S., Kingsmore, S. F., Trimmer, J. S., Saunders, C. J., and J. T. Sack. (2015) A Novel Epileptic Encephalopathy Mutation in KCNB1 Disrupts Kv2.1 Ion Selectivity, Expression, and Localization. J. Gen. Physiol. 146:399-410. PMID: 26503721.
Cerda, O., Leiva-Salcedo, E., Park, K.-S., Cáceres, M., Romeroa, A., Varela, D., Trimmer, J. S., and A. Stutzinband. (2015). Casein Kinase-Mediated Phosphorylation of Serine 839 Is Necessary for Basolateral Localization of the Ca2+-Activated Non-Selective Cation Channel TRPM4. Pflugers Arch. 467: 1723-1732. PMID: 25231975.
Jan, L. Y., Attali, B., Nerbonne, J., Sanguinetti, M. C., Trimmer, J. S., Chandy, K. G., Grissmer, S., Gutman, G. A., Lazdunski, M., Mckinnon, D., Pardo, L. A., Robertson, G. A., Rudy, B., Stühmer, W., and X. Wang. (2015).Voltage-Gated Potassium Channels. IUPHAR/BPS Guide to PHARMACOLOGY.
Cáceres, M., Ortiz, L., Romero, A., Recabarren, T., Colombo, A., Leiva-Salcedo, E., Varela, D., Rivas, J., Silva, I., Campusano, C., Almarza, O., Simón, F., Toledo, H., Park, K.-S., Trimmer, J. S., and O. Cerda. (2015). TRPM4 is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility. PLoS ONE 10:e0130540. PMID: 26110647.
Hirono, M., Ogawa, Y., Misono, K., Zollinger, D. R., Trimmer, J. S., Rasband, M. N., and H. Misonou. (2015). BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J. Neurosci. 35:7082-7094. PMID: 25948259.
Trimmer, J. S., and H. Misonou. (2015). Ion Channel Phosphorylation. (Chapter 36, pages 531-544). In The Handbook of Ion Channels. (J. Zheng and M. C. Trudeau, Editors). CRC Press, Boca Raton, FL.
Hsiao, J. J., Ng, B. H., Smits, M. M., Wang, J., Jasavala, R. J., Martinez, H. D., Lee, J. A., Alston, J. J., Misonou, H., Trimmer, J. S., and M. E. Wright. (2015). Androgen Receptor and Chemokine Receptors 4 and 7 Form a Signaling Axis to Regulate CXCL12-Dependent Cellular Motility. BMC Cancer 15:204. PMID: 25884570.
Trimmer, J. S. (2015). Subcellular Localization of K+ Channels in Mammalian Brain Neurons: Remarkable Precision in the Midst of Extraordinary Complexity. Neuron 85: 238-256. PMID: 25611506.
Mandikian, D., Bocksteins, E., Parajuli, L., Bishop, H. I., Cerda, O., Shigemoto, R., and J. S. Trimmer. Cell Type Specific Spatial and Functional Coupling Between Mammalian Brain Kv2.1 K+ Channels and Ryanodine Receptors. J. Comp. Neurol. 2014 Oct 15;522: 3555-3574.
King, A. N., Manning, C. F., and J. S. Trimmer. A Unique Ion Channel Clustering Domain on the Axon Initial Segment of Mammalian Neurons. J. Comp. Neurol. 2014 Aug 1;522: 2594-2608.
Baek, J.-H., Rubinstein, M., Scheuer, T., and J. S. Trimmer. Reciprocal Changes in Phosphorylation and Methylation of Mammalian Brain Sodium Channels in Response to Seizures. J. Biol. Chem. 2014 May 30;289: 15363-15373.
Trimmer, J. S. Ion Channels and Pain: Important Steps Towards Validating a New Therapeutic Target for Neuropathic Pain. Exp. Neurol. 2014 Apr;254: 190-194
Speca, D. J., Ogata, G., Mandikian, D., Bishop, H. I., Wiler, S. W., Eum, K., Wenzel, H. J., Doisy, E. T., Matt, L., Campi, K. L., Golub, M. S., Nerbonne, J. M., Hell, J. W., Trainor, B., Sack, J. T., Schwartzkroin P. A., and J. S. Trimmer. Deletion of the Kv2.1 Delayed Rectifier Potassium Channel Leads to Neuronal and Behavioral Hyperexcitability. Genes, Brain and Behavior 2014 Apr;13: 394-408.
Sack, J. T., Stephanopoulos, N., Austin, D. C., Francis, M. B., and J. S. Trimmer. Antibody guided photoablation of voltage-gated potassium currents. J. Gen. Physiol. 2013 Sep;142:315-324.
Vacher, H., and J. S. Trimmer. Trafficking Mechanisms Underlying Neuronal Voltage-gated Ion Channel Localization at the Axon Initial Segment. Epilepsia 2012 Dec;53 (suppl. 9): 21-31.
Manning, C. F., Bundros, A. M., and J. S. Trimmer. Benefits and Pitfalls of Secondary Antibodies: Why Choosing The Right Secondary is of Primary Importance. PLoS ONE 2012;7: e38313.
Menegola, M., Clark, E., and J. S. Trimmer. The Importance of Immunohistochemical Analyses in Evaluating the Phenotype of Kv Channel Knockout Mice. Epilepsia 2012 Jun;53 (suppl. 1): 142-149.
- Established Investigatorship, American Heart Association
- National Institute of Neurological Disorders and Stroke, National Institutes of Health, Jacob Javits Neuroscience Investigator (MERIT) Award
- UC Davis Graduate Student Association Award for Excellence in Service to Graduate Students
- NPB 107, Cell Signaling in Health and Disease
- National Institutes of Health


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Bishop Takes Climate Principles To The Doors of Wittenberg
Via Ecumenical News International:- Anglican Bishop Richard Chartres of the London Conference of European Churches "has pledged to refrain from air travel for a year, as a sign of his commitment to the environment." Hence his recent journey to Wittenburg for a conference of Bishops, "meant a 1000 kilometre train voyage with changes in Brussels and Berlin"..."Travel takes rather longer," Chartres told Ecumenical News International in Wittenberg, the town where Martin Luther instituted the Reformation...His vision is that "every single church in some way or other … is going to be a place where energy is captured from God, the sun, the wind and transformed into energy for the common good." Image credit: Conference of Churchs OK. We admit to a bit of hyperbole in the headline. In 1517, Martin Luther pinned 95 propositions on the doors of Wittenburg Cathedral (pictured), whereas our contemporary Bishop Chartres has exressed a vision and is fulfilling only a one-year pledge. Yet, there is something righteous sounding about the comparison, given Luther's disdain for buying indulgences [carbon credits] and the modern Bishop's propensity for personal action.
The portait of Bishop Chartres, we must say, is stunning.


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POWAY -- Sheriff's deputies chased and arrested a 22-year-old man Monday night who allegedly threatened to commit suicide. Sgt. Mike Petrofsky said Todd Lavay of Poway was taken to the county Mental Health Center, then booked into Central Jail.
Deputies were called about 10 p.m. Monday to an Ipava Drive home because of the suicide threat, Petrofsky said. He said Lavay drove away from the residence just before deputies arrived.
Lavay's vehicle was spotted on Poway Road. Deputies tried to stop the driver, but he continued onto Highway 67 towards Ramona. The car shot out of control near Air Mail Lane, Petrofsky said.
Lavay crashed, got out of the car and ran, the sergeant said. He said deputies who caught Lavay discovered he had knives on him. Lavay was placed in a patrol car and he kicked out a door window, Petrofsky said.
Deputies arrested Lavay on suspicion of felony evading an officer, resisting arrest and felony vandalism.


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401 91 666 (Sat-Thu : 7AM to 5PM) 600 54 00 48 (Sat-Thu : 8AM to 6PM) 22052622 (Sat-Thu : 9AM to 7PM) 22034034 (Sat-Thu : 8AM to 6PM) (00973) 17558320 (Sat-Thu : 9AM to 7PM) 920022330 (Sat-Thu : 8AM to 6PM)
The GS3700 traditional sewing machine featuring a wide range of stitches ideal for repairs, dressmaking and home furnishing projects. Includes features designed to make sewing quick and easy such as automatic needle theader and quick set bobbin system. While the LED light is bright and gentle on the eye and will last the lifetime of the machine.
With a rich history spanning more than a century, Brother has grown from humble beginnings into a diversified multinational corporation. While its technology and business activities have evolved over time, a foundation of strong leadership and product innovation has remained a constant throughout Brother's history and remains just as important today as it was in 1908.
All-the-basics sewing machine for garments, crafts, and mending.
Convertible Sewing Surface
The GS3700 has a convertible sewing surface which allows you to use the flatbed for garment construction or flat sewing and the free arm for pants hems or sleeves. This machine is easy to thread and also features a quick bobbin winding system.
37 Built-in Stitch
37 built-in stitch functions include straight, zig-zag, satin, elastic, and blind hem.
Automatic Buttonholer
Built-in automatic 4-step buttonholer; auto-set stitch length and width adjustment. The stitch length and width adjustments are auto-set for you. The presser feet feature Brother's easy change snap on design.
Easy Threading
Easy threading and quick set bobbin winding; snap-on presser feet. It has thread tension control dial.
Only GCC cards accepted.
While every care has been taken to ensure the product information represented is correct, Luluwebstore.com cannot guarantee the content displayed in terms of ingredients etc. is correct at all times. Products are constantly being reformulated so ingredients, nutrition content, dietary and allergens may change. Luluwebstore.com recommends you to always read the product label and not rely solely on the information provided on the website.If you have any queries, please contact customer service at firstname.lastname@example.com


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Regarding the error: What is
/usr/xxx/xxx.cvs? Is it a path you set
$remotePath to? The purpose of the script is to find the latest file in a directory. So the
$remotePath should be set to a path to the directory, not a specific path.
Posting a complete error message, or even better a log file, would help.


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As an Allergic Girl who coaches the food allergic community about living well with food allergies, I love hearing about new, potentially safe dining-out spots. I was excited when a little bird, GFBird on Twitter, told me about a new restaurant in Brooklyn that she thought I'd want to try:
"I came across an eatery in Brooklyn that may be Sloane-friendly. It's called Cochinita, and is 100% GF, save for a few brands of regular bottled beer. In chatting up the owner, Adam, I found out that he has severe nut and shellfish allergies, so I know he "gets it", as far as cross-contamination, etc. It's a very casual place, with a small space for indoor seating and a backyard patio opening in mid-May...a great place to have in your back pocket if you'll be out and about in Brooklyn." Here's her review on her blog, GF Bird.
An allergic boy running a restaurant? This I definitely had to check out. I had some back and forth over email with Adam Frank, the owner and chef about his allergies and about what he serves. He is peanut, tree nut and shellfish allergic. They have no tree nut or peanuts or shellfish on site and one fish dish, fish tacos. He asked me if being near fish would bother me. No, I replied but so kind of you to ask. (Very important to know your food allergic situation – go back to your board certified allergist if you have questions about aerosolized proteins.) So off we went to talk with Adam and try his cuisine. Here's a video about our wonderful experience.
Cochinita, which means little pig, is a Mexican-based restaurant and Chef/Owner Adam is clearly passionate about that cuisine and his restaurant. A clean, tidy, modern space with an open kitchen, they were prepping their mini-flans, fish for tacos and afterwards, beef for tacos. Everyone was properly gloved and washing up (I watched) in their separate preparation sections.
The Cochinita menu is tailored (read: small) which is good for those with dietary restrictions as there are not many ingredients nor allergens to contend with. Adam went over how he creates the recipes himself, they have a recipe book behind the counter if you have questions about the ingredients of a dish (love that), all the necessary sanitizing steps they take, as well as cross contamination precautions. Feeling secure enough to try (on camera!), with all my emergency medications on me, my emergency plan in my phone and my safe friend with me (the producer, Heidi Bayer of Numodo and Brooklyn Allergy Mom), I dove in.
I tried the beef taco (made with a tiny amount of gf tamari) which is, I think, my fave. A brisket-like cut of beef, with that background note of extra umami from the gf tamari equaled delish. The pork was next up, so flavorful, perfectly pulled, well-spiced and seasoned. The chicken, that's the plate with the rice and beans in the video, was like the chicken you'd pull after you made a chicken soup – tender, tasting of carrots, celery and onion and simple. The rice – what is in there Adam? Green love? (and some cilantro). They have one fryer and all it makes are fried tortilla chips, dedicated to corn chips, only in canola oil.
And if you needed more incentive, everything is green - plates, forks,
spoons, cups - all compostable - which they do as well. LOVE!
Everything was delicious, well-seasoned and totally yummy. OK, now are you ready to watch the video? Here it is!
Thank you Adam and Cochinita for creating a safe space for those of us who love homemade, authentic Mexican cuisine. And like to be green. And happen to have dietary restrictions.
Contact Adam at email@example.com if you have additional questions and tell him Allergic Girl sent you!
922 Fulton Street
Brooklyn, NY 11238


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How ado you find the domain?
How ado you find the domain?
The domain of √(x+5) is x ≥ -5, and the domain of √(x-1) is x ≥ 1.
The domain of f(x)=3√(x+5)+7√(x-1) is the conjunction of x ≥ -5 and x ≥ 1.
Answer: x ≥ 1.
Robert gave a good answer for your specific question. In general when asked to find the domain of a function, we are interested in values of x where we get a real valued answer. That means the inside of a radical expression must be non negative. So they can be 0 or 4 but not -3 or -14 for example inside of the radical, since the solution to negative radicals are complex and this outside of our domain.
Therefore the expression sqrt(x+5), the x+5 must be positive or zero, so the least number x can be is -5. When we consider both expressions, both must follow this rule which is why we get that x must be greater than or equal to -1.


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Legal Question in Discrimination Law in New York
what kind of lawyer should i contact for harrassment and being forced to transfer out for being sexual harrassed by my general manager and where to i start my case
Asked on 11/06/12, 10:12 am
1 Answer from Attorneys
Scott Ziegler Ziegler, Ziegler & Associates LLP
An employment lawyer that specializes in sexual harassment cases. Chris Brennan in our office handles such cases. He can be reached at 212-319-7600
Answered on 11/06/12, 10:26 am


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Author Talk: August 21, 2009
August 21, 2009
Laura Caldwell is the acclaimed author of such novels as BURNING THE MAP, A CLEAN SLATE and THE ROME AFFAIR. Her latest offering is a trilogy of thrillers --- RED HOT LIES, RED BLOODED MURDER and RED, WHITE & DEAD --- that released this summer in successive months, featuring entertainment lawyer Izzy McNeil. In this interview, Caldwell compares her own personality traits to that of her protagonist, and weighs the pros and cons of releasing the second and third installments so quickly after the first. She also explains why she had trouble publishing her first novel and shares some of the famous Chicago landmarks where events in the books take place.
Question: RED HOT LIES kicked off a summer mystery trilogy with the other books released in July and August. How did you come up with the idea for this series?
Laura Caldwell: I had never written a series before and the thought somewhat intimidated me, because these characters would have to expand and grow over the course of the books, I was sure. I had never particularly enjoyed a series where characters don't age or change very much as the books progress. Another challenge was how to allow a reader to start on book number 2 (RED BLOODED MURDER) or book number 3 (RED, WHITE & DEAD) and to give them enough background information without giving away what happened in the previous books. Although they are a trilogy, the books are crafted so that they can be read in any order.
What I found was that I enjoyed writing the trilogy tremendously. I loved the fact that at the end of a book, I didn't have to give up the character. Instead, I was about to bring them right back. I would get to see what they did next. I also love the ability to explore different concepts, character traits and experiences that a character might have and see how they would respond to new ones. All the characters in these Red books --- not just the main character --- evolve during the course of the trilogy.
Q: In what ways are you and Izzy alike and in what ways are you different?
LC: What Izzy and I have in common --- red hair; troublesome blushing problems; attended University of Iowa for undergrad; attended Loyola University Chicago for law school; took classes at Loyola of Rome during a law school summer; we're both Chicago lawyers; she lives in Old Town near where I used to live; she and I both love dive bars, especially the ones with popcorn machines.
Differences between Izzy and me --- she is younger; she is cooler; I've never moonlighted as a private eye (although I did stake out a witness once with one of the best PIs in the city of Chicago while I was researching this book); although I've done some entertainment law, Izzy's entertainment law practice is at a much higher level than mine was; I used to drive a scooter, but after an accident decades ago, I gave it up and yet I still miss it.
Q: How long did it take you to write RED HOT LIES and what was the toughest challenge in writing the book?
LC: RED HOT LIES took about nine months to write, which I consider pretty fast. I turned it in, but the manuscript ended up getting tweaked numerous times because MIRA, my fabulous publisher, decided to put all the books out in Summer 2009, so every time something big changed in books #2 or 3, RED HOT LIES had to be changed accordingly. I ended up having to write RED BLOODED MURDER and RED, WHITE & DEAD even faster than the first one, but that was a blessing, too, because I was able to hold all three books in my head at once and edit them accordingly.
Q: As the author, how exciting was it to have a new book out in June, July and August?
LC: Putting out 3 books back-to-back-to-back is a relatively new concept within the literary world, although it's been done with much success in the romance world for years. Only recently did the concept hit the mystery market. One of the best examples of quick-release books are the excellent novels by Allison Brennan --- THE PREY, THE KILL, and THE HUNT. When MIRA proposed the 3-month release of the Izzy McNeil books, I was thrilled at first, but then I realized that all my deadlines would have to be truncated. 2008 was a fast and furious year, which at any given time involved writing one book, editing another and plotting out yet another all at once. My assistant was a huge help in this process, as were my agent and editor. Our hope is that people will love Izzy McNeil and her adventures as much as we do and will get hooked on the first book and quickly come back for RED BLOODED MURDER and RED, WHITE & DEAD.
Q: You started out writing chick lit and moved to mysteries. Was that a smooth transition and why the genre change?
LC: When I first started writing, I wrote a story called BURNING THE MAP about a girlfriends' trip to Italy and Greece that changes their lives. There was no "chick lit" market in existence then --- no BRIDGET JONES'S DIARY (at least not in the US), no "Sex and the City" on TV yet --- and I didn't consider the novel "chick lit" since the term hadn't yet been developed. Because of the lack of that market, there was a distinct lack of love toward BURNING THE MAP. I couldn't find an agent. But I loved reading mysteries and thought I might have better luck there. So I moved on and wrote a mystery. By the time I met the woman who would become my editor at a cocktail party, I was already working on mystery number two. I sold BURNING THE MAP first, followed by three more chick lit novels, then I sold six mystery/thrillers, including the Izzy McNeil/Red trilogy.
Q: Chicago works as the setting for several reasons doesn't it?
LC: Chicago is a character and not just in the Izzy McNeil books. It is a fascinating, fluid city. Not only does our weather change constantly --- testing us and delighting us --- but the city itself doesn't sit back and rest on any kind of laurels. Instead, Chicago is constantly striving, adapting, changing. And yet there are so many great things about Chicago that never change --- the good-natured people, the Midwest work ethic, our ability to bounce back from profound sports losses. And hey, our politics are entertaining, too.
Q: What are some of your personal favorite Chicago landmarks mentioned in the Izzy McNeil series?
LC: So many parts of the city are explored in RED HOT LIES, RED BLOODED MURDER and RED, WHITE & DEAD, from restaurants to events to landmarks to everyday locales. Here are just a few:
- RL Restaurant (the only Ralph Lauren restaurant in the world)
- Old Town
- Marge's
- Lincoln Square
- the Loop
- North Avenue Beach
- Lincoln Park Zoo
- Old Town Art Fair
- Café Brauer
- Peggy Notebaert Nature Museum
- Lake Forest
- Union League Club
- Roscoe Village
- Nomi at the Park Hyatt
- Old Town Ale House
- Lincoln Park
- Viagra Triangle
- Hugo's Frog Bar
- Chinatown
- East Bank Club
- St. Pat's Block Party
- Michigan Avenue
(And if you don't see a location or a locale in the books that you'd like to have appear in following books, please email your suggestions to email@example.com).
• Click here now to buy this book from Amazon.


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Legal Question in Wills and Trusts in California
At what time does someone accrue the right for a social security check that they have been receiving? At midnight on the 1st of the month? Or, when electronically deposited on the "2nd" or "3rd" of the month?
Here is a situation. A person receiving month social security checks finally passes away. They pass away on the "2nd" of the month. A social security check is deposited electronicly in the account on the "3rd" of the same month. But the account is set up as joint tenancy and TOD. Is the asset "owned" by the senior citizen before they pass away, (e.g., right of asset accrues just past midnight on the "1st" of the month, enabling the Fed to cut the check) and therefore transferred as an asset to the TOD/joint tenant recipient? Or, is the social security check considered and asset of the estate and not an asset of the TOD beneficiary since it arrived in the account after someone deceased?
1 Answer from Attorneys
Social Security Administration is your best source for information as to when the recipient is entitled to receive the benefit, and whether the benfit is for past period or for a prospective period,, which should then be a guide to you as to whether you are entitled to the benefit as a joint survivor or POD beneficiary.


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The Current Certificates table contains a brief summary of the main certificate attributes.
Current Certificates
Click the numbered link to get more details of a particular certificate. A Certificate Detail window opens. Only one detail window can be open at one time.
Indicates whether this certificate is a CA (Certificate Authority) or local (router) certificate.
Indicates the availability of the certificate.
Shows whether the certificate is used for signature only, encryption, or both (general purpose).
The information about the certificate owner. If one subject needs several different certificates signed by one CA, such certificates can have the same value of this field.
A distinguished name which is a sequence of several object IDs with their corresponding values.
What date the specific certificate is no longer valid or activated.
The details of the certificate authority that the access point uses for certificate operations.
Current Public Keys
Digital certificates are based on public key cryptography where each participant is issued a public key (shared widely) and a private key (not shared). The keys are very large integer in computer-readable form and are interrelated so that anything encrypted with the public key requires the private key to decrypt it and vice versa. The certificate is digitally signed with the key of the issuing authority, the signature is verified, and the contents of the certificate are validated.
A consecutive numbering of the keys.
The name assigned to the individual name or organization who is in possession of the certificate holder's public key.
A brief description of the key type.
To transfer a software certificate, you need to export it and its associated private key in a suitable interchange format of the machine in which the certificate is first installed. This column specifies whether the key and certificate can be copied to other systems you use.
The date and time when the certificate was recognized. A certificate is valid only for a limited amount of time.
Configure Trustpoints and Certificates
Current Trustpoints
Which certificate authorities the access point is currently using for certificate operations.
Trustpoint Name
The unique name assigned to define or group the details of the certificate authority together.
The router must contact the CA or RA to enroll in the PKI. Cisco IOS software enrolls with the CA via SCEP (Cisco's Simple Certificate Enrollment Protocol), which uses HTML as the application protocol and thus requires the router to have the URL to enroll. The CA documentation should offer the enrollment URL, which varies from vendor to vendor.
The details of the subject field in the requested X.509 certificate.
Revocation Check
Specifies whether to perform a certificate renovation check for a received certificate. For EAP-TLS, this should be set to None.
RSA Key Pair Label
An optional name to identify the RSA keys for the certificate.
Signature/Encryption Size
The number of bits required for the RSA keys. Larger sizes are more secure.
Regenerate on Enroll
If this option is chosen, the RSA keys generate when the certificate is enrolled with the certificate authority.
Certificates are automatically enrolled when the trustpoint is configured. You do not need to explicitly download the CA certificate and then enroll the router certificate because it is done automatically.
CA Certificate
After defining the trustpoint, click the Retrieve button to download the certificate authority certificate.
Router Certificates
After successfully retrieving the CA certificate, click the Enroll button to enroll the access point certificate(s) with the CA. This sends a certificate enrollment request to the CA and installs the received certificate(s). This may happen immediately or might take some time depending on the settings of the CA. For example, some CAs are set to immediately issue the certificate, while some might require human intervention, delaying the issuance of the certificate for some time.
Don't delete associated keys
When a trustpoint is deleted, the associated RSA keys are also deleted. If you want to keep the keys intact, this option must be chosen before deleting the trustpoint.


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Much has been made of the recent involvement of news organizations going beyond standard journalistic roles while covering the aftermath of the earthquake in Haiti.
That's been especially true for the TV doctors. Bob Steele, a journalism values scholar at the Poynter Institute, tells the LA Times' Matea Gold, "I think it's very hard for an individual who is professionally and emotionally engaged in saving lives to be able to simultaneously step back from the medical work and practice independent journalistic truth-telling."
"I may blur the rules of dispassionate journalism," ABC News correspondent Dr. Richard Besser tells Gold, "but I think it would be impossible to be a true physician working as a journalist and not help when you can contribute."
During his Monday Webchat, WaPo's Howard Kurtz was asked, "Are there ethical questions — both medical and journalistic — that are being ignored here?" Kurtz says he has "mixed feelings" about it.
Gawker has raised, more sarcastically, its own questions about whether there is "something off-putting" about CNN's on-camera "heroics." While the NYTimes' Alessandra Stanley wrote over the weekend,t "The line between compassion and self-congratulation is thin on television; in a calamity this vast and acute, many viewers flinch at any sign of reportorial showboating." Mediaite's Steve Krakauer, writing about Anderson Cooper's co-hosting of this Friday's multi-network telethon asks, "Has CNN entered gray area of becoming, not just reporting, the story in Haiti?"
In general, how do you feel about intervention by anchors and reporters in Haiti?(survey)