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PHOENIX—The Dodd-Frank bill deserves an F for failing to provide the necessary information on capital markets to the government and , instead, creating more bureaucratic financial regulatory oversight, said former Securities and Exchange Commission Chairman Harvey Pitt Monday. Pitt, currently chief executive officer of Kalomara Partners, LLC, was addressing Investment Management Network's "Super Bowl of Indexing" conference here.
This continued lack of foresight will have an inevitable impact on our economy since "we haven't seen the worst of the financial crisis we have been enduring for the past three years," Pitt said.
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subset: commoncrawl


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New 2017 GMC Acadia Limited FWD Limited
Sale Price $41,193
See Important Disclosures Here
What a wonderful deal! A great deal in Rosenberg! GMC has outdone itself with this fantastic 2017 GMC Acadia Limited. It just doesn't get any better at this price! This Acadia Limited is nicely equipped. This SUV will save you money by keeping you on the road and out of the mechanic's garage. Located just 5 minutes south of Sugarland, Texas.


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We Welcome Our New Friends into the Majors Home Improvement Family
Here are just a few of the new members of the family:
From the TV series, "Home Improvement" with Tim the Tool Man Taylor, what state did the Taylors live in? A. Indiana B. Florida C. Vermont D. Michigan
The Case for a Reface
What makes our Cabinet Refacing better? Cabinet refacing is a quick and elegant way to update the look of your kitchen without the mess and hassle of a full kitchen remodeling project. Refacing is a perfect option if you love the current layout of your kitchen, but have fallen out of love with its dated look. If your cabinet boxes are in great shape, you can completely transform the look of your kitchen with a variety of door styles, from modern to traditional.
What is cabinet refacing? Refacing involves removing the cabinet doors, drawers, handles and knobs, hinges, and hardware. Then the cabinet boxes and frames are covered with a
beautiful laminate or wood veneer of your choice. Brand new custom made doors are hung in place with European concealed hinges. Last, new custom drawer boxes with all new whisper glides are installed with your choice of knobs and pulls to compliment your new kitchen. Many older homes have kitchens with quality cabinet boxes. So long as your kitchen has cabinets that are in good structural condition, refacing can be a cost-effective option to beautify your kitchen space. The design possibilities are endless with beautiful wood finishes to painted doors for that cottage style.
Is cabinet refacing more cost effective than just replacing my cabinets? The average kitchen remodel was $51,050 in 2013, according to the 2013 National Kitchen and Bath Association Design Trends Survey. Refacing will be considerably less since you only have to replace the cabinet doors and drawers, leaving the existing cabinet box in place. Upgrading the cabinet doors and drawers will deliver the best design "bang for your buck" since this is mainly what you see when looking at your kitchen space.
How can refacing change the look of my kitchen?
Cabinet refacing can create the kitchen of your dreams with the entire process taking just 3-5 days from start to finish. Select grade wood doors come in a variety of wood species from cherry, maple, bamboo and more. Several colors, finishes or painted options are available with pulls and knobs to complement your simple or elegant design. For a designer touch, cabinet doors can also be fitted with glass. Refacing has the advantage of adding additional functionality in your space. You can add lazy susans, tilt-out drawers, pull outs, spice racks and more. Last, you can add more cabinet storage space above your refrigerator or add a kitchen island to your project. Don't forget, cabinets located throughout your home from laundry to kitchen and bath can be updated at the same time.
Have Majors help you update your kitchen space without a major remodel. Get the new look that you have always wanted in 3-5 days with cabinet refacing. Contact us for a free in-home consultation.
"I had a great experience working with Majors Home Improvement, from my first contact with their salesperson to the end of my job. The price they provided was better than the other estimates I received, and their sales presentation was much better than the other presentations I saw while receiving estimates."
Answer: First, you will need to vacuum your couch with a brush attachment. Then spray rubbing alcohol onto the dirty, dingy areas. Don't fret - alcohol will evaporate quickly and will not leave a mark like water. If you have concerns, always test in an inconspicuous spot.
Next, rub over the area with a clean scrub sponge. It should be a dry, white sponge. Then, let the area dry completely. Last step is to rub the fabric with a clean, soft scrub brush in small circles. Again, use a dry brush with white bristles. The fabric of your microfiber sofa will be fluffed and feel soft again.
In the Spirit of Giving Thanks
From the Majors Home Improvement family, we express thanks this season to our customers. Here are 7 simple
ideas to make your Thanksgiving more memorable...
1. Plan a neighborhood football game for the Thanksgiving weekend. 2. Invite extra guests to share in your family meal. 3. Donate to your favorite charity such as the Waterfront Mission. 4. Ask each family member to share their favorite Thanksgiving memory. 5. Send a care package overseas for our military. 6. Provide a Thanksgiving meal to a family in need.7. Volunteer at a senior center or veteran's home.


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Investors Buy Shares of Allergan PLC (AGN) on Weakness
Investors purchased shares of Allergan PLC (NYSE:AGN) on weakness during trading hours on Thursday. $324.28 million flowed into the stock on the tick-up and $231.47 million flowed out of the stock on the tick-down, for a money net flow of $92.81 million into the stock. Of all equities tracked, Allergan PLC had the 4th highest net in-flow for the day. Allergan PLC traded down ($4.68) for the day and closed at $255.56
Several brokerages have issued reports on AGN. Morgan Stanley reiterated a "buy" rating on shares of Allergan PLC in a research report on Saturday, April 9th. Goldman Sachs Group Inc. lowered shares of Allergan PLC to a "buy" rating in a research report on Saturday, May 14th. Citigroup Inc. reiterated a "buy" rating on shares of Allergan PLC in a research report on Sunday, May 29th. Piper Jaffray Cos. reiterated a "hold" rating and set a $236.00 target price on shares of Allergan PLC in a research report on Saturday, June 18th. Finally, Mizuho lowered shares of Allergan PLC from a "buy" rating to a "neutral" rating and dropped their target price for the company from $330.00 to $250.00 in a research report on Wednesday, April 6th. Seven analysts have rated the stock with a hold rating, sixteen have given a buy rating and one has assigned a strong buy rating to the company's stock. The company presently has an average rating of "Buy" and an average price target of $308.74.
The company's 50 day moving average is $239.54 and its 200 day moving average is $254.18. The stock has a market cap of $101.09 billion and a P/E ratio of 22.87.
Allergan PLC (NYSE:AGN) last issued its quarterly earnings results on Tuesday, May 10th. The company reported $3.04 earnings per share (EPS) for the quarter, topping analysts' consensus estimates of $3.03 by $0.01. The company earned $3.80 billion during the quarter, compared to the consensus estimate of $3.97 billion. The business's revenue was up 48.1% compared to the same quarter last year. On average, analysts predict that Allergan PLC will post $14.17 earnings per share for the current fiscal year.
In other Allergan PLC news, CFO Maria Teresa Hilado bought 661 shares of the firm's stock in a transaction dated Thursday, June 2nd. The stock was acquired at an average cost of $241.57 per share, for a total transaction of $159,677.77. Following the completion of the transaction, the chief financial officer now owns 11,957 shares in the company, valued at $2,888,452.49. The acquisition was disclosed in a document filed with the SEC, which is available through this link. Also, Director Nesli Basgoz sold 459 shares of Allergan PLC stock in a transaction on Wednesday, May 11th. The stock was sold at an average price of $225.10, for a total value of $103,320.90. Following the sale, the director now owns 5,242 shares of the company's stock, valued at $1,179,974.20. The disclosure for this sale can be found here.
Several hedge funds have added to or reduced their stakes in AGN. Dimensional Fund Advisors LP increased its stake in Allergan PLC by 6.9% in the fourth quarter. Dimensional Fund Advisors LP now owns 1,596,389 shares of the company's stock valued at $498,895,000 after buying an additional 103,314 shares during the period. Edgewood Management LLC increased its stake in Allergan PLC by 10.9% in the fourth quarter. Edgewood Management LLC now owns 1,459,579 shares of the company's stock valued at $456,118,000 after buying an additional 143,657 shares during the period. Eaton Vance Management increased its stake in Allergan PLC by 276.7% in the fourth quarter. Eaton Vance Management now owns 793,555 shares of the company's stock valued at $247,986,000 after buying an additional 582,890 shares during the period. Principal Financial Group Inc. increased its stake in Allergan PLC by 1.2% in the fourth quarter. Principal Financial Group Inc. now owns 533,175 shares of the company's stock valued at $166,617,000 after buying an additional 6,382 shares during the period. Finally, Atlantic Trust Group LLC increased its stake in Allergan PLC by 2.3% in the fourth quarter. Atlantic Trust Group LLC now owns 466,883 shares of the company's stock valued at $145,901,000 after buying an additional 10,553 shares during the period.
Allergan, Inc is a multi-specialty healthcare company. The Company focuses on developing and commercializing pharmaceuticals, biologics, medical devices and over-the-counter (OTC) products. It discovers, develops and commercializes a range of products for the ophthalmic, neurological, medical aesthetics, medical dermatology, breast aesthetics, urological and other specialty markets.
Get Analysts' Upgrades and Downgrades Daily - Enter your email address below to receive a concise daily summary of analysts' upgrades, downgrades and new coverage with MarketBeat.com's FREE daily email newsletter.


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Once was there a little man, who's old man was supposedly a true believer in aliens (the main reason why he was called delusional). Si, in an effort to make light conversation while eating dinner with old man:
"Wouldn't it be kewl if alienz were to invade ze Earth?"
Old man:
"Cant you see???!!!?! we ARE the bloody aliens! Stop the bloody invasion!"


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Outerwear has never been so full of attitude!
-Represent the off-duty look in this fierce Camo jacket.
-With its bold Utility style, chic Camo print, two pockets to the front and a zip fasten,
-Team with a basic jersey top, ripped shorts and black heeled boots for a festival flair.
About Size Table
About HAODUOYI
Haoduoyi Specializes in design and production of Euramerican modern clothing.
We have many well-experienced designers,top fabric suppliers and mature flexible supply chain.
We committed to satisfy each and every woman from in every single place the world who loves youth and beauty.
We all the time take the interests of consumers as the center,providing the most cost-effective clothing,serving for the whole world.
It's our unchanged pursuit.
Please check our size table before you place orders,and if in case you have any questions please feel free to contact us.
We're going to get back to you within 24 hours.
Top of the range material, soft to touch and comfortable to wear
More comfortable to wear and it's going to not appear tight feeling
Garment Care: Hand-wash and Machine washable, Dry Clean
We guarantee we can 100% slove any problem for you and make you satisfied
We care about our valued customers,and will all the time try that can assist you,hope to establish long business with you


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Posted: Friday, August 18, 2017 12:07 AM
Company Name: CRHC Freedom Metals LLC
CRHC Freedom Metals, LLC is currently looking for a General Manager for our Winchester, KY location that will oversee the day to day operations of the scrap yard facility.
This willl include, but not limited to overseeing the processing, receiving, inventory and shipment of all scrap metals.
Qualified candidate must have a minimum of 5 years experience in scrap yard management & knowledge of Ferrous and Non-Ferrous Metals.
Positive attitude with strong interpersonal skills to help train and motivate others. Must have an understanding and able to comply with safety regulations.
We offer competitive pay and benefits package. Please email resume to: firstname.lastname@example.com
• Location: Lexington, Winchester, KY
• Post ID: 14587473 kentucky


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We are specialized in the organization and implementation of internal as well as national and international machine transportations, delivery of new equipment, the relocation to new locations. We can shift your products or systems where you want, according to your specifications and requirements.
Our professional staff is able to absorb your peak capacity and increase your productivity. Mechanics, electricians, electronic engineers, commissioning engineers, and programmers are at your assistance.
Wear, stress, and age, can damage to your equipment. Quick, inexpensive and professional repairs minimize your loss. After estimating the damage, we are able to organize the spare parts and their assembly.
We can be your international machine movers!


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Fast and accurate scalper
Buget $30-250 USD
Evaluate different scalping systems (available to be provided) and create a fast and accurate scalper(EA) from indicators used in scalping systems
8 freelanceri ofertează în medie 636$ pentru acest proiect
Dear, I can perform this job for $80. I've done about 692 jobs. [url removed, login to view]
what version of metatrader 4 or 5 you used? send discription of ea before accept project.
Hi, I have read and understood the project outline and will gladly offer an outstanding service. Please give me a chance. A trial will convince you. Looking forward to work with you. Thanks


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$25,000 Cash Giveaway at The Taj Mahal, Atlantic City
February 5, 2009
Filed under Promotions
On Thursday, February 19,2009 between 4pm - 8pm you can win your share of $5000 every hour at The Trump Taj Mahal. The casino is having a promotion where if you activate you entry by playing a slot or table game between 8am and 7pm then you are eligible for a prize an hour. Prizes every hour are as follows: Grand Prize is $2,500, 2nd Prize is $1,250, 3rd Prize is $500, 4th Prize is 6 winners of $250each. The announcements will happen in the main concourse, so don't miss it!
We Recommend:
- Vineyards Golf at Renault Winery
- Annex at the Chelsea CLOSED December 2016
- Free Parking at the Golden Nugget Atlantic City Extended!
Jay Jackson
Latest posts by Jay Jackson (see all)
- Atlantic City Bachelor Party Packages - June 29, 2017
- Jay Leno - Borgata Event Center - July 02, 2017 Discount Tickets - June 25, 2017
- The WHO Atlantic City - Boardwalk Hall - July 22, 2017 Discount Tickets - June 25, 2017


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Big Leo Productions
Client: big leo photo agency
Role: Creative direction & Design
Meet Big Leo!
The wonderful photography & stylists "repping" agency I've gotten the opportunity to work with fresh into my move to NYC. I've spent my time with them working on design projects, library organization and archiving, promotional videos, as well as a smattering of other odd jobs - kind of the most ideal "out of college" experience ever.
Mary Dail, Owner also had some nice things to say about our time together...
"Any time you see something cool coming out of the Big Leo offices besides the amazing photography and styling talents of our artists, then chances are, it is the doing of K.Nicole Murtagh. Her youthful, fun, and inventive designs have graced our website and emailers, many of our artist promos and websites, the first inception of our Big Leo agency book called "My Little Orange Book", our special deliveries to clients, and much, much more.
With an easy going and collaborative style of working, Nicole has made being creative the highlight of our days.
Her seasoned grasp on design solutions has enabled her to quickly implement changes, while her cutting-edge ideas have served to help elevate our little brand to very BIG places.
Enjoy some of our projects together below!
Big Leo Takes Sweet Revenge
I joined the team just in time for Big Leo Month and the clever promotional idea they had baked up (quite literally) with local cupcake business Sweet Revenge. Tagging along on their oh so sweet revenge, I got the opportunity to capture the days events as they unfolded. It was a blast!
More on the den: Big Leo took Sweet Revenge!
Website Design
Site developed on PhotoFolio
Temporary Rebranding
With a ton of new projects rolling out, we decided explore a type driven update of the company's already existing branding. Keeping the same colors & typefaces, we used the gold star as an recognizable element that kept the two designs tied together. This branding was in effect for several years.
Agency Artist Catalog
Big Leo, NYC based artist representation agency, was in need of a fresh new way to show off their photographers and build momentum for new clients. "My Little Orange Book" is cute, compact, and now available to the masses! See the full preview over at Blurb and then head over to Big Leo's new website to see more of the artists work.
Printed Collateral
Whoever said print is dead hasn't see an agent's office. Promotions are a big part in getting your artists names out there and basic mailers are still one of the best ways to do that.
In addition we've collaborated on other basic printed collateral that all small businesses need.


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Graceland University summer baseball camp
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Get the facts about Graceland University summer baseball camp, and registering for discussion sections and departmental electives. Not all recruiting is done like NCAA Division I teams. It's practically impossible for college coaches to watch every player who has expressed interest in their program, so if you get the chance, make a memorable first impression by visiting the campus in person. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Graceland University Baseball information. Please use the form above to request admissions info for Graceland University.
As a student athlete, you can play college sports competitively at an intercollegiate level, or just for fun via intramurals. Please keep in mind that few students will qualify for athletic scholarships, and that college coaches sward available sports scholarship money judiciously.
Approximately 126,000 student athletes go to college on either a partial or full athletic scholarship, but the vast majority of college athletic teams have open tryouts, and walk-ons may land a position on the team if they are talented enough. If you've been recruited or made it past a walk-on tryout, that's when the real challenge starts. You still have to make it through daily practices, and several rounds of cuts in order to make the team. Missouri Baptist University womens basketball ranking may indicate that it's an option to delay college entrance by a year. An extra year in high school or prep school can allow players to mature mentally, bring grades and SAT test scores up, put on weight and gain strength. Beyond consideration for Graceland University summer baseball camp, you may think about SUNY Sullivan County Community College specifications for complementary electives to your primary course of study.
Training and Curriculum Development Consultant
The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran..
2 days ago Assistant Coach - Football
University of North Texas
The Assistant Football Coach, under the direct supervision of the Head Coach of the respective athletics team, is responsible for assisting the Head Coach in..
6 days ago Wellness Coordinator
YMCA of Greater Omaha
Develops, models and integrates systems and practices that encourage and sustain positive relationships and retention of members/participants.
3 days ago Boxing/Kickboxing Fitness Instructor
Title Boxing Club - West Wichita
Ability to confidently lead our signature POWER HOUR classes using our structured approach, work with members one-to-one, provide clear instructions, correct..
7 hours ago Varsity Boys Soccer Coach
Waterford School District
Substantial knowledge of the fundamental and technical aspects of Boys Soccer. Must abide by the Waterford School District Coaches Handbook.
2 hours ago


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Bike Ride
3602 ft
- Begins in:
- Monterey, VA, United States
- Created By:
- iogato
- Description:
- This is a 52.9 mi Bike Ride in Monterey, VA, United States. The Bike Ride has a total ascent of 3602.81 ft and has a maximum elevation of 3,489.7 ft. This route was created by iogato on 07/31/2007. View other Bike Rides that iogato has done or find similar maps in Staunton.
- Starts From:
- other
- Type:
- Bike Ride


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Arizona Business and Employment Litigation
Serving Phoenix, Chandler, Mesa, Tempe, and the Surrounding Areas
We have made our mark in litigation and continue to pride ourselves on our successful litigation record. At the Law Offices of David C. Larkin, P.C., we are experienced, effective trial attorneys with an aggressive edge. Contact us at (480) 491-2900. With significant jury trial experience in State and Federal courts, we provide the highest quality representation.
Some areas of our litigation practice include:
- Business law disputes: small business shareholder/partnership disputes, breach of contract, tortious interference with business, business torts, vendor disputes, purchase/sale disputes
- Employment disputes: harassment, discrimination, wage and hour claims, disputes over compensation agreements, executive agreements, non-competes or other restrictive covenants, whistle-blower suits, and wrongful termination actions
- Appeals
Our attorney, David C. Larkin, has high standards for trial performance and is committed to your case from the beginning through its resolution. In Arizona, employment and business litigation requires an experienced attorney. If you are in need of a trial lawyer, contact the Law Offices of David C. Larkin, P.C.
David C. Larkin, P.C. provides professional legal services in Arizona counties including Maricopa County, Pinal County and Yuma County. Serving clients in Ahwatukee, Avondale, Buckeye, Carefree, Casa Grande, Cave Creek, Chandler, Gilbert, Glendale, Goodyear, Mesa, Queen Creek, Paradise Valley, Peoria, Phoenix, Scottsdale, Surprise, Tempe and Yuma. Call today at (480) 491-2900. Our attorney can help prevent or resolve legal problems in your employment or business.


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1. CONGRATULATIONS to our ATHLETES OF THE MONTH, Rachel Stradling and Caleb Pumphrey. To LEARN more about Caleb and Rachel, SEE the display case by the ATHLETIC OFFICE.
2. CONGRATULATIONS to the NEW FALCON PRIDE STUDENTS: Emily Ogden, Ciara Green, Eli Hughes and Taylor Wilkins!
3. The BOWLING GREEN STATE UNIVERSITY MEN'S CHORUS will PERFORM at GMS Friday EVENING, November 11, at 7:30. ADMISSION is FREE. A free will offering will be collected to help defray touring costs
4. The ENTIRE JUNIOR CLASS will be TAKING a PRACTICE ACT NEXT Wednesday MORNING, November 9, from 7:45 to 11:15. JVS students in attendance for the test WILL NOT be COUNTED ABSENT from Ohio Hi-Point. PARENT PERMISSION is REQUIRED for ANY JVS student planning to LEAVE AFTER the test. JUNIOR JOB PLACEMENT and JUNIOR PSEOP students: you MUST MAKE ARRANGEMENTS IN ADVANCE with your EMPLOYER and COLLEGE PROFESSORS to be HERE for the TEST. ALL JUNIORS are to CHECK the ORANGE POSTINGS in and around the CAFETERIA for TESTING ROOM ASSIGNMENTS.
5. If you are INTERESTED in being a WRESTLING STATISTICIAN this season, SEE Mrs. Schlater THIS WEEK in the MEDIA CENTER BEFORE FIRST PERIOD. If you are NOT ABLE to see her BEFORE FIRST PERIOD, LEAVE your name THIS WEEK with Mrs. Kauffman in the media center.
6. There will be a BASEBALL MEETING TODAY AFTER SCHOOL in ROOM A108.
7. The OHIO STATE UNIVERSITY CHAMPAIGN COUNTY ALUMNI SCHOLARSHIP is AVAILABLE in the GUIDANCE OFFICE.
8. SOPHOMORES will be able to take the PLAN TEST (practice ACT) Wednesday MORNING, November 16, in the MEDIA CENTER during PERIODS 1-5. SIGN UP and PAY the $11.25 FEE in the MAIN OFFICE by NEXT Thursday, November 10.
9. REMINDER to STAFF and STUDENTS: The AUXILLARY GYM will be CLOSED ALL DAY TOMORROW for the BLOOD DRIVE. NO ONE will be ADMITTED into the GYM until AFTER SCHOOL. Please be courteous to our donors and respect their privacy while donating. THOSE DONATING: TODAY drink plenty of fluids and get a good nights rest. TOMORROW: EAT A GOOD BREAKFAST. It is important to eat the morning of the blood drive. BE READY at your APPOINTMENT TIME. If you are a STUDENT DONATING, someone will ESCORT you from your classroom to the gym. DO NOT JUST SHOW UP! Be sure to BRING a PHOTO ID and parent permission form if applicable. You will DONATE a PINT of blood (it will take 45-60 minutes). AFTER DONATING: Drink plenty of fluids and eat (snacks will be available). THE DAY AFTER DONATING: Still drink plenty of fluids.
Daily Announcements >


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Terrorists walk free as threats cripple the justice system
The Counter Terrorism Department in Punjab has admitted in an internal report that more than two thirds of terrorism cases in the past two decades have collapsed as a result of mistakes made by investigating officers and the intimidation of witnesses, prosecutors and even judges.
The internal analysis, seen by The Times, comes in the wake of the release last month of Malik Ishaq, who was accused of masterminding the attack on the Sri Lankan cricket team in 2009. Ishaq, acquitted of 35 cases, was garlanded with flowers by supporters after walking free in Lahore last month. He was driven from jail with an escort of militants, armed with Kalashnikov rifles, from Lashkar-e-Jhangvi, the Sunni extremist group he heads.
Before his arrest in 1997 Ishaq…


text: I have a Panasonic 56" widescreen HD Mon. I had a progessive scan DVD player but it really didn't help as I could only get 480 and 1080 resolution on the tv. So I got the HD931 in order to watch the DVDs on a higher output resolution. Here's my opinion of it. First, the remote...It is a little small but I think we're just used to the bigger universal remotes. This makes the smaller size of the DVD remote much more noticable. However, if you're careful with the use it works fine although you do have to point it directly at the unit. The blue light on the jog/shuttle control really is annoying as it's to bright. It takes a bit of work to get it set up correctly. Mine came out of the box wih both DTS and 5.1 turned off. I had to go into the menus to get it turned on. However, watching at 1080i res does make a huge difference. Beautiful picture quality. It's especially awesome on digital DVDs like Toy Story etc. Specifically, the opening scenes of Toy Story 2 where Buzz Lightyear is in the game sequence is really amazing. I don't have Nemo yet but A Bug's Life is equally as awesome. I have a couple of films backed up and sometimes it sticks on those but not often. All in all it's a good unit. The anamorphic DVDs sized really well. 4:3 films stretch which is annoying. Personally, unless you need 1080i on a DVD player, I'd wait before purchasing this unit. No Hi-Def DVDs plus the higher price make this thing nothing more than the latest toy. But for those who do want the 1080i res, it's woth the $$$. Just be sure to read the manual and spend your time setting it up correctly. Tim-L


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Baywatch Jaco – Keeping our beaches safe!
The Central Pacific Chamber of Commerce in conjunction with the Municipality of Garabito made possible the integration of four lifeguards in Jaco Beach during Semana Santa. Marvin Perez, Rigoberto Villalobos Vásquez, César Herrera Samudio and Lizandro Porras Garita are the 4 lifeguards who keep swimmers visiting the beaches of Jaco safe.
These young heroes have also been outfitted with a state of the art lifeguard tower. Beach goers in Jaco have never had it so good. Not only does our little slice of beach have some of the best surfing in the world, but Jaco Beach now has the support and safety of and integrated beach emergency response team. So get out there and catch some waves knowing that the watchful eye of Jaco's finest lifeguards have your back.
For More Information or if you are interested in helping support a similar program in Jaco, please contact the local Chamber of Commerce at 2643-2853.


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Besides making my Grandmother's flower garden/Tillie's Mosaic quilt, which is the best hand sewing project I can recommend for waiting on Doctors, and at bedsides in hospitals, I've been enjoying other sensory perceptions.
The new Indiana Jones movie was like being on a ride at an amusement park. I never really engaged with the movie-action or script. But, you got to see it, because it's picks up somewhat from the original movie and I guess it's okay. If nothing else, they brought back Karen Allen who, a while back was a really great actress that seemed to drop off the planet for a while, but, now we can see her again. She's knitting, I understand, so she must be a great person, maybe could have been a little better if she's a quilter, but, knitting is good...smile.
A better afternoon spent is watching a French film with subtitles, the Diving Bell and the Butterfly. It's about the editor of Elle Magazine who has a stroke at the age of 42 and how he writes a book just by blinking it out to a nurse. The French really are cutting edge movie makers and some of the scenes in this movie are impossible-I won't give away anything. This is an interesting movie and the soundtrack is awesome-I recommend buying that, the variety is wonderful, U2 to Tom Waits, luscious.
The book I was given as some fluff reading is Stealing Shadows by Kay Hooper. It's a nice page turner with detective/psychic/serial killer finder/person...you know what I mean. The book is a romantic thriller and I usually shy away from this type of thing, but, I started reading it and couldn't stop.
So, there you have, may while away the time while I while away the time ideas for you.
Ain't Life grand...smile


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FRANK SINATRA; Why Question His Mental Powers?
Published: November 28, 1993
To the Editor:
In Stephen Holden's article "Pop's Patriarch Makes Music Along With His Heirs" [ Oct. 31 ] , in which he recounts Frank Sinatra's triumphant return to the recording studio, the author notes that some people question the performer's mental powers. Really? How many of us are as sharp as we were 30 years ago? Talk about a low blow. Who wouldn't be nervous returning to a medium after 10 years?
I'm sure Mr. Sinatra is well aware he is not the same singer he was 30 years ago. But then he wasn't the same singer in the 50's as he was in the 40's, nor the same singer in the 80's as he was in the 60's. That is what has made him last: He adapted to the times, and just when you thought that was it, he was back bigger than before. Even today, at the age of 77, nobody can bring you down or bring you up like Frank Sinatra. This man truly makes the whole world sing. REG IRVING Nepean, Ontario


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How to lose weight on your face and neck
These people will sometimes ask me one factor like "OKAY, I need to strive it, however I don't know recommendations on the best way to start. The potential for quite a few features on various physique strategies may be very promising because the testimonials for all types of diseases retains pouring in. You probably can divide this meals routine plan in three components in response to your wants. Full grain carbs and healthful, low-starch greens and fruits are best for weight discount. Eating effectively doesn't how to lose weight on your face and neck starvation. How can i lose weight with thyroid problems you can carry your own lunch, then you possibly can pre-slice lemons and limes, and have them to add to your water. Burpees may be nice for fat loss as a result of in the long run they're simply one different form of cardio practice. Even when sporting security gear it's doable to be critically injured if workers won't be cautious or aren't properly knowledgeable of the dangers they face. By: Celena Markovski Mar eleventh 2010 - That is in all probability most positively one of the best methods I check out love tackle exercises: Inside the occasion you happen to dont start with the fundamentals, your effort will virtually undoubtedly be put to waste. Our bodies are designed to protect themselves from anything that interfers with our survival. Be conscious of the income hungry quick meals enterprise its deadly meals. Why. By controlling how so much sugar you would have gotten in your weight discount plan will go an extended approach to getting good outcomes together collectively collectively along with your weight discount program and cut back your hazard of degenerative sicknesses. 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text:
Relationships are the safest investments with the highest yields.
In life, you may accumulate a lot of material things but that can all go away in an instant.
Economies shift, currencies plummet, and bad things can happen at any time. But no one can take away your relationships.
If there's only one area that you could make more investments in, let it be your relationships. It will not lead to disappointments.
But before you drop everything and start calling everyone, it's worth to cover a few important things.
First of all, not all relationships are made equal. And like investment, you should do your homework first before going all in.
Like all good things in life, it takes time for a great relationship to get to fruition. This means you need to pace it and not rush it.
Second of all, not anything called relationship has to be romantic, so most of these apply to all types of them.
And finally, great relationships are not matched, they are made. Sure, someone can make an introduction but there's no guarantee for that to succeed without your effort.
Great relationships also have a natural flow to them, they get started at the right time and at the right place.
There are times when they can flourish effortlessly but that's because of the right synergy between two people. It creates an equal opportunity for both sides to grow.
So how many of these great relationships can you handle?
Well, there's the concept of Dunbar's Number which suggests we can only maintain stable social relationships with up to 150 people.
In these relationships, each individual knows who every other person is and how they relate to each other.
But in reality, that number is much lower. Just think of your own life and see how many of those relationships you are in.
It's true that you need to be always meeting new people and not be limiting yourself to a specific number.
But it's also good to be aware of our human limitations to maintain meaningful relationships.
Even if you end up having 50 great relationships that help you grow, you'll have an amazing life to be proud of. Are 50 not enough? Well, you don't need to stop there if you have the time for it.
Working with people is one of the best ways to start building great relationships. Nothing brings people closer to each other than sharing wins and fails together.
In great relationships, you go through ups and downs with someone else who shares the same concerns and outcomes. That's the key to success.
Traveling is another great way to get the same results. When you go on a trip with someone, small or big doesn't matter, you'll end up going through the same challenge and hopefully the same reward.
It can take anytime between 6 months to 6 years for a great relationship to reach its full potential and no one knows the exact date.
But the point here is to be aware of the importance of trust and respect in a relationship while creating value for others.
I hope this has inspired you to start investing more in your relationships and be able to find the good ones so you can double down on them.
I've taken on a 90-day writing challenge to get better at writing. Every business day I write about my life lessons including wins and fails.
Want to be a part of this journey and learn something new? Leave your email address below and get my next post in your inbox.


text:
I wasn't sure if I'd be able to grow tomatoes given that they're meant to be tricky, and I have a poor gardening track record. However, this is my harvest from two plants.
I decided to take all of them off the vine even though most are still green. It's starting to get too cold and the vines are dying, which is affecting the fruit. With the experience I now have, I think I would get a lot more ripe tomatoes if I grew them again.
I decided to make some green tomato chutney with the slightly dodgier tomatoes. I followed Nigel Slater's recipe, doubled. I didn't have many jars left after my courgette jam exploits so had to make do with an odd selection. I ended up with seven jars of varying sizes- most of them quite large.
Here's 2kg of homegrown toms bubbling away.
I also made a simple salad inspired by my recent holiday to Greece. The tomato is combined with nectarine and ricotta with a basil dressing. It's a bit like a twist on a tricolore. I also grew the basil. The plant was a bit of a casualty of the holiday, so I had to use it all up quickly.
Recipe from The Silver Island Cookbook.
In the past couple of weeks, my garden has started to produce a lot of courgettes. I got the seeds as part of a 'funky veg' kit and kind of just planted for the hell of it- I'm not the biggest fan of courgettes. However, I sense that my glut of yellow beauties may make me learn to love this humble vegetable. We'll see how I do at the challenging task of not embarrassing myself with phallic references in this post. I am a follower of Freud, after all.
I turned my first fistful of small courgettes into a tasty salad. Adapted from this recipe.
I knew that my staff summer picnic would be a good excuse to use up some more courgettes. As you can see, these ones were much larger.
I made another salad for the party- this was actually my first time cooking and eating fennel. I selected a vegan recipe, but when the vegan in the team wasn't at the picnic, I did add some cheeky feta. Cheese makes everything better.
I also made a courgette cake. Since I've blogged previously about chocolate courgette cake, I used this recipe as a jumping-off point.
The cake was lovely- light, moist and tasty. Would probably omit raisins next time. My favourite bit was the frosting, but then I am dangerously addicted to cream cheese frosting. I have a LOT more courgettes coming, so I need to stay ahead of the game with ways to use them.
The second instalment in my quest to stop lunch being the most irritating meal of the day is this filling roasted sweet potato, quinoa and goats cheese salad. I realise that eating things like this (stopping to Instagram it first) makes me a hopeless millennial stereotype, but apparently that's my destiny.
Couldn't you just filter the shit out of that? Then eat it?
I'll be adding this to my rotation of lunches. I think the goats cheese balances the sweet potato beautifully, the quinoa adds grainy bulk and the pumpkin seeds give a pleasant bite. I leave the skins on my potatoes (cutting out any dodgy bits) for the triple threat of added nutrition, saved time and reduced waste. Rule of three FTW!
I've also started adding dressing to more of my salads. It does add calories, but I think the secret of store bought salads is the dressing punching up the flavour. For me, the added pleasure negates the calories.
- 1kg sweet potatoes
- 1tbsp finely grated fresh ginger
- 1 green or red chilli, finely chopped
- 2 cloves garlic, finely chopped
- 2tbsp olive oil
- A handful of finely chopped coriander stems, optional
- Fine sea salt and freshly ground black pepper
- 1 cup dry quinoa (if you're not on the quinoa bandwagon, sub another grain, bulgur or couscous)
- 200g baby leaf spinach
- 50g pumpkin seeds
- 200g goats cheese, cut into small chunks
- A handful coriander leaves
For the dressing
- 1tbsp French mustard
- 1tbsp honey
- 2tbsp cider vinegar
- 1 clove garlic, peeled and crushed or finely chopped
- 1tsp balsamic vinegar
- 6tbsp flavourless oil
- Preheat oven to 180C
- Chop your sweet potatoes into bite-size chunks. Peel if desired.
- Add sweet potato chunks to a roasting tin with the olive oil, garlic, ginger, chili and coriander stems, if using. Rub to ensure a good coating of oil and even distribution of the spices. Season, then bake for around 20 minutes, until the sweet potato is soft and golden.
- Cook quinoa according to directions on packet. I rise mine in a mesh sieve for a couple of minutes, until the water runs clear. I then toast the damp quinoa in a tablespoon of butter for a couple of minutes to open up the grains. Finally, I add double the volume of water to the pan (in this case 2 cups), bring to the boil, cover and simmer until the water is all absorbed (15-20 mins), then turn off the heat and leave to steam for a few more minutes.
- For the dressing, Combine the dressing ingredients, aside from the oil, in a food processor or hand blender and blitz until smooth. Add the oil slowly, through a funnel if you have one, until smooth.
- In a dry pan over a medium heat, toast the pumpkin seeds until golden and fragrant.
Combine the baby leaf spinach, quinoa, roasted sweet potato, goats cheese and coriander. Sprinkle with pumpkin seeds, season and dress to taste. This salad can be eaten warm or cold. Enjoy!
Sun's out, buns out… of my lunch box, that is. The magnificent weather had reinvigorated my quest against lunch ennui, resulting in this tasty salad.
I found the recipe that inspired me, via Pinterest, here. Feel free to substitute any of the vegetables for other root vegetables you like. I also chucked a couple of shallots in the roasting tin as I had them on hand.
Ingredients (serves four)
- 800g (about two medium) sweet potatoes
- 400g (one root) celeriac
- 300g (two medium) parsnips
- 2tbsp olive oil
- 2 cloves garlic
- 1tsp fennel seeds
- 200g washed baby spinach
- 160g washed other leaves (I used sprouted peas)
- 200g pomegranate seeds, or one pomegranate if you're not lazy
- 200g feta, cubed
- 2 avocados
- 50g pumpkin seeds
For the dressing
- 1tbsp French mustard
- 1tbsp honey
- 2tbsp cider vinegar
- 1 clove garlic, peeled and crushed or finely chopped
- 1tsp balsamic vinegar
- 6tbsp flavourless oil
- Preheat oven to 200C (400F)
- Chop all of the root vegetables into bite-sized dice. Peel if desired. I peeled the celeriac but not the sweet potato and parsnips. Place into a baking tray.
- Coat evenly with the olive oil and sprinkle over the fennel seeds. Place in the garlic cloves (no need to peel or chop)
- Bake for 20-25mins, until golden brown and tender.
- Combine the dressing ingredients, aside from the oil, in a food processor or hand blender and blitz until smooth. Add the oil slowly, through a funnel if you have one.
- Cut open avocado, remove store, scoop out the meat and cut into smaller cubes. Add the avocado to the salad leaves along with crumbled feta and pomegranate seeds
- Heat a small saucepan, add the pumpkin seeds and a little sprinkle of salt and toast until golden.
- Mix the roasted roots with the salad and top the salad with toasted pumpkin seeds. Add dressing to taste.
I make this salad ahead of time for work. I put my roasted roots in a large airtight container in the fridge, with the feta, pomegranate and toasted pumpkin seeds in separate containers.
Each morning, I put the leaves in my lunchbox, topped with the roots and other ingredients. I take my dressing in a separate container and dress the salad just before eating. It's a little more effort doing it this way, but gives a really enjoyable result.
The salad is also very nice undressed. You could add a tablespoon of honey to the vegetables before you roast them for extra flavour.
My basil plant continues to flourish, so I needed another lunch idea. Something fresh, flamboyant and delicious. Something… Italian.
Each day, I have a tomato, a third of a ball of mozzarella and a third of an avocado. I'm not sure if avocado is traditional, but who can resist something healthy that has the texture of butter? The dressing is a handful of basil leaves blitzed with some salt, a few pine nuts and some olive oil. Next time, I'll add a clove of garlic too. Garlic makes everything better.


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Smoked Turkey Provolone Croissant
Quick InfoBreakfast, Lunch Poultry Under 15 min 1
- Sponsored By: Sargento® Foods, Inc.
- Featured Product: Sargento® Deli Style Sliced Sharp Provolone Cheese
Jazz up your croissant with this easy recipe that calls for smoked turkey and provolone!
- 1 large red leaf or romaine lettuce leaf
- 1 large croissant, split, lightly toasted if desired
- 2-oz. thinly sliced deli smoked turkey or ham
- 2 tsp. horseradish sauce
- 1 thin slice red onion
- 1 to 2 slices Sargento® Deli Style Sliced Sharp Provolone Cheese
Place lettuce on bottom of croissant; top with turkey. Spread horseradish sauce over turkey; top with onion and Sargento® Deli Style Sliced Sharp Provolone Cheese. Close sandwich.
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Minhang District Central Hospital
Minhang District Central Hospital
Wei Z.,Shanghai University |
Chen X.,Minhang District Central Hospital |
Chen J.,Shanghai University |
Wang W.,Shanghai University |
And 2 more authors.
Biochemical and Biophysical Research Communications | Year: 2013
Ras association domain family (RASSF) proteins are encoded by several tumor suppressor genes that are frequently silenced in human cancers. In this study, we investigated RASSF10 as a target of epigenetic inactivation and examined its functions as a tumor suppressor in gastric cancer. RASSF10 was silenced in six out of eight gastric cancer cell lines. Loss or downregulation of RASSF10 expression was associated with promoter hypermethylation, and could be restored by a demethylating agent. Overexpression of RASSF10 in gastric cancer cell lines (JRST, BGC823) suppressed cell growth and colony formation, and induced apoptosis, whereas RASSF10 depletion promoted cell growth. In xenograft animal experiments, RASSF10 overexpression effectively repressed tumor growth. Mechanistic investigations revealed that RASSF10 inhibited tumor growth by blocking activation of β-catenin and its downstream targets including c-Myc, cyclinD1, cyclinE1, peroxisome proliferator-activated receptor δ, transcription factor 4, transcription factor 1 and CD44. In conclusion, the results of this study provide insight into the role of RASSF10 as a novel functional tumor suppressor in gastric cancer through inhibition of the Wnt/β-catenin signaling pathway. © 2013 Elsevier Inc.
Feng L.,Minhang District Central Hospital |
Xie Y.,Minhang District Central Hospital |
Zhang H.,Minhang District Central Hospital |
Wu Y.,Shanghai JiaoTong University
Medical Oncology | Year: 2012
MicroRNAs (miRNAs) have emerged as posttranscriptional regulators that are critically involved in the pathogenesis of a number of human cancers. Recently, cyclin-dependent kinase 6 (CDK6) is found to be up-regulated in several types of human tumors and has been implicated in cancer initiation and progression. We have identified miR-107 as a potential regulator of CDK6 expression. A bioinformatics search revealed a putative target site for miR-107 within the CDK6 3′ untranslated region. Expression of miR-107 in gastric cancer cell lines was found inversely correlated with CDK6 expression. miR-107 could significantly suppress CDK6 3′ UTR luciferase reporter activity, and this effect was not detectable when the putative 3′ UTR target site was mutated. Consistent with the results of the reporter assay, ectopic expression of miR-107 reduced both mRNA and protein expression levels of CDK6, inhibited proliferation, induced G1 cell cycle arrest, and blocked invasion of the gastric cancer cells. Our results suggest that miR-107 may have a tumor suppressor function by directly targeting CDK6 to inhibit the proliferation and invasion activities of gastric cancer cells. © Springer Science+Business Media, LLC 2011.
Feng L.,Minhang District Central Hospital |
Xie Y.,Minhang District Central Hospital |
Zhang H.,Minhang District Central Hospital |
Wu Y.,Shanghai JiaoTong University
Biochemical and Biophysical Research Communications | Year: 2011
The expression of N-myc downstream-regulated gene 2 (NDRG2) is present in normal tissues but low or undetectable in various cancers and thus poses a potential tumor suppressor gene. However, the expression of NDRG2 in colorectal tissues remains unknown. Here, our results showed that NDRG2 was down-regulated in colorectal cancer compared to benign colorectal tissues by using immunohistochemical staining and semi-quantitative RT-PCR analyses. Bisulfite sequencing analysis showed that the reduced NDRG2 expression was accompanied by de novo DNA methylation at the NDRG2 promoter. We also found that microRNA-650 (miR-650) targets a homologous DNA region in the promoter region of the NDRG2 gene and represses its expression at the transcriptional level. Reporter assay with 3'untranslated region of NDRG2 cloned downstream of the luciferase gene showed reduced luciferase activity in the presence of miR-650, providing strong evidence that miR-650 is a direct regulator of NDRG2. In conclusion, these results suggest that NDRG2 expression is regulated by promoter methylation and miR-650 in human colorectal cancer cells, and endogenous small noncoding RNA induced control of transcription may be a potential system for expressional regulation in human colorectal cancer cells. © 2011 Elsevier Inc.
Qing P.,Minhang District Central Hospital |
Han L.,Shanghai JiaoTong University |
Bin L.,Rui Jin Hospital |
Yan L.,Shanghai JiaoTong University |
Ping W.X.,Minhang District Central Hospital
Journal of Cellular Biochemistry | Year: 2011
Human helicase-like transcription factor (HLTF) is a functional homologue of yeast Rad5 that regulates error-free replication through DNA lesions. HLTF promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA) that is required for maintaining genomic stability. Here, we identified the deubiquitylating enzyme ubiquitin-specific protease 7 (USP7) as a novel regulator of HLTF stability. We found that USP7 interacted with and stabilized HLTF after genotoxic stress. Furthermore, USP7 mediated deubiquitination significantly prolonged the half-life of HLTF, which in turn increased PCNA polyubiquitination. More intriguingly, silencing of USP7 rendered A549 cells highly sensitive to DNA damage and over-expression of HLTF attenuated this sensitivity. Thus, our results delineate a previously unknown USP7-HLTF-PCNA molecular network controlling DNA damage response. © 2011 Wiley Periodicals, Inc.
Dong W.,Zhengzhou University |
Feng L.,Minhang District Central Hospital |
Xie Y.,Minhang District Central Hospital |
Zhang H.,Minhang District Central Hospital |
Wu Y.,Shanghai JiaoTong University
Cancer Science | Year: 2011
LMX1A is epigenetically inactivated in cervical cancer. However, the expression and methylation status of LMX1A in gastric cancer tissues remains unknown. In the present study, we found that the expression of LMX1A was significantly decreased in gastric cancer tissues compared with normal tissues. A statistically significant inverse association was found between the LMX1A methylation status and expression of LMX1A in tumor tissues (P=0.008). Restoration of LMX1A induced cell apoptosis and suppressed anchorage-independent growth, suggesting LMX1A may be a potential biomarker for gastric cancer. © 2010 Japanese Cancer Association.
Wang Q.-B.,Minhang District Central Hospital |
Zhu H.,Fudan University |
Liu H.-L.,Minhang District Central Hospital |
Zhang B.,Minhang District Central Hospital |
Zhang B.,Shanghai JiaoTong University
Hepatology | Year: 2012
A meta-analysis was performed to assess and compare the accuracies of magnetic resonance elastography (MRE) and diffusion-weighted imaging (DWI) for the staging of hepatic fibrosis. Online journal databases and a manual search from January 2000 to May 2011 were used. We identified 41 studies, but only 14 met the criteria to perform a meta-analysis assessing MRE (five trials) or DWI (10 trials). Fibrosis was categorized by redistribution into five stages according to histopathological description. A bivariate binomial model was used to combine the sensitivity and specificity and their 95% confidence intervals (CIs), from which diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and summary receiver operating characteristic (sROC) were derived to indicate the diagnostic accuracy of imaging modalities. With MRE, the sensitivity, specificity, DOR, PLR, NLR, and area under sROC curve (with 95% CIs) for staging F0 ~ F1 versus F2 ~ F4 and F0 ~ F2 versus F3 ~ F4 were 0.94 (0.81-0.98), 0.95 (0.87-0.98), 20 (7-57), 0.06 (0.02-0.22), 317 (55-1,796), 0.98 (0.97-0.99) and 0.92 (0.85-0.96), 0.96 (0.91-0.98), 21 (10-45), 0.08 (0.04-0.16), 251 (103-609), and 0.98 (0.96-0.99), respectively; and with DWI, these values were 0.77 (0.71-0.82), 0.78 (0.69-0.85), 3 (2-5), 0.30 (0.22-0.40), 12 (6-21), 0.83 (0.79-0.86) and 0.72 (0.60-0.81), 0.84 (0.77-0.89), 5 (3-7), 0.34 (0.23-0.50), 13 (6-29), and 0.86 (0.83-0.89), respectively. A z test demonstrated that MRE had a significantly higher accuracy than DWI in those indicators (P < 0.05). Conclusion: MRE is more reliable for staging hepatic fibrosis, compared with DWI, with a high combination of sensitivity, specificity, likelihood ratios, DOR, and area under sROC curve. © 2012 American Association for the Study of Liver Diseases.
Chen Q.-H.,Minhang District Central Hospital |
Wang Q.-B.,Minhang District Central Hospital |
Zhang B.,Shanghai JiaoTong University
Tumor Biology | Year: 2014
Common functional polymorphisms in the promoter region of microRNAs (miRNAs), based on multiple lines of evidence, might participate in transcriptional regulation and other biological processes, which interact to increase the risk of developing breast cancer. Since 2005, many studies have investigated the association between breast cancer risk and common single nucleotide polymorphisms (SNPs) in miRNAs. However, the findings of several meta-analyses are inconclusive or ambiguous. The aim of this Human Genome Epidemiology meta-analysis was to determine more precisely the relationship between common miRNA polymorphisms and breast cancer risk. Twelve case-control studies with a total of 7,170 breast cancer patients and 8,783 healthy controls were included. Eight SNPs in miRNA genes were examined. When all eligible studies were pooled in the metaanalysis, the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, and miR-605 rs2043556*A alleles predicted a decreased risk of breast cancer among Asians, while not Caucasians. In addition, the miR-27a rs895919*C allele might be a protective factor for breast cancer among Caucasians. However, for the miR-146a rs2910164 (G>C), miR-149 rs2292832 (G>T), miR-373 rs12983273 (C>T), and miR-423 rs6505162 (C>A) polymorphisms, we failed to find any significant association with the risk of breast cancer in any genetic model. In conclusion, the current meta-analysis supports that the miR-196a-2 rs11614913*T, miR-499 rs3746444*T, miR-605 rs2043556*A, and miR-27a rs895919*C alleles might be protective factors for breast cancer.
Zhang P.,Minhang District Central Hospital |
Lu Y.,Shanghai JiaoTong University |
Yu D.,Minhang District Central Hospital |
Zhang D.,Minhang District Central Hospital |
Hu W.,Minhang District Central Hospital
Cellular Physiology and Biochemistry | Year: 2015
Background: Tumor necrosis factor receptor-associated protein 1 (TRAP1), an essential mitochondrial chaperone is induced in rat hearts following ischemia/reperfusion (I/R), but its role in myocardial I/R injury is unclear. The present study examined the function of TRAP1 in cardiomyocyte hypoxia/reoxygenation injury in vitro and myocardial I/R injury in vivo. Methods: HL-1 cardiomyocytes transfected with TRAP1 or vector were subjected to simulated I/R (SI/R) in vitro. Cell death and mitochondrial function were assessed. Wild type (WT) and TRAP1 knockout (TRAP1 KO) mice were subjected to cardiac I/R in vivo. The infarct size and myocardial apoptosis were determined. WT and TRAP1 KO cardiomyocytes were subjected to SI/R in vitro. Mitochondrial function was assessed. Results: TRAP1 overexpression protects HL-1 cardiomyocytes from SI/R-induced cell death in vitro. The reduced cell death was associated with decreased ROS generation, better-preserved mitochondrial ETC complex activity, membrane potential, and ATP production, as well as delayed mPTP opening. Loss of TRAP1 aggravates SI/R-induced mitochondrial damage in cardiomyocytes in vitro and myocardial I/R injury and apoptosis in vivo. Conclusion: The results of the present study show that TRAP1 provides cardioprotection against myocardial I/R by ameliorating mitochondrial dysfunction. © 2015 S. Karger AG, Basel.
Zhao J.,Minhang District Central Hospital |
Wu H.,Minhang District Central Hospital |
Zheng L.,Minhang District Central Hospital |
Weng Y.,Minhang District Central Hospital |
Mo Y.,Minhang District Central Hospital
Brain Research | Year: 2013
Background and purpose Recovery after stroke varies considerably between individuals. An abundance of evidence suggests that genetic factors contribute to stroke recovery. The aim of this study was to determine whether or not the BDNF G196A polymorphism independently influences the occurrence, severity, and 90-day functional outcome in Chinese patients with ischemic stroke (IS). Methods BDNF G196A genetic variants were investigated in 494 IS and 346 controls. Severity was assessed by the National Institutes of Health Stroke Scale at the time of admission. Three hundred and eight patients were assessed 90 days post-stroke using the Modified Rankin Scale to determine stroke outcome. Results We showed that a significant association existed between the BDNF G196A AA genotype and the occurrence of IS (P=0.021), even after adjustment for covariates (P=0.028). The AA genotype of the BDNF G196A was associated with a poor outcome of recovery 3 months after stroke onset (P=0.008) was a novel finding, independent of other known predictors of poor outcome (P=0.012). Conclusions The BDNF G196A polymorphism was significantly associated with the occurrence and long-term outcomes of IS, thus BDNF G196A may be used as a prognostic biomarker and therapeutic target in IS. © 2013 Elsevier B.V.
Tian H.,Fudan University |
Huang P.,Fudan University |
Zhao Z.,Fudan University |
Tang W.,Fudan University |
And 2 more authors.
Cellular Physiology and Biochemistry | Year: 2014
Background/Aims: Hypoxia promotes the progression and metastasis of hepatocellular carcinoma (HCC). Hypoxia inducible factor-α (HIF-lα) regulates the expression of various chemokines involved in tumor growth, angiogenesis and metastasis.Methods: The role of HIF-la in HCC tumor growth and invasion and the prognosis of patients with HCC was investigated in cell lines and patient samples. HIF-lα mRNA and protein levels were assessed by gRT-PCR and western blotting. Silencing of HIF-lα downregulated the expression of granulocyte chemotactic protein-2 (GCP-2)/CXCL6, a CXC ELR+ chemokine, in HCC cells, and a luciferase assay showed that HIF-lα binds to a hypoxia response element in the promoter of CXCL6 and regulates its transcription. Induction of HIF-lα by hypoxia promoted the migration and invasion of HCC cells in vitro, and this effect was suppressed by an anti-CXCL6 antibody.Results: HIF-la is upregulated in HCC cell lines and tissues and its effect on promoting invasion and metastasis is mediated by its direct interaction with the pro-angiogenic chemokine CXCL6. CXCL6 expression was associated with poor prognosis of HCC patients. αConclusion: HIF-lα promotes HCC progression and metastasis by upregulating CXCL6 transcription in HCC cells, providing a potential novel therapeutic target for the treatment of HCC. Copyright © 2014 S. Karger AG, Base.


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Welcome to The Royal Cove Hotel, we are consist of 11 Self contained Suites in a scenic and quite area in the Southern side of Antigua. Of these rooms we have Single Room Suites, Deluxe Room Suites, Two Bed Room Suites and One Penthouse Suite.
Royal Cove Hotel consists of six(6) one bedroomn suites, two(2) double room suites (rooms consist of two single beds). In our two 2 bedroom suites all rooms have a Queen size Bed. All rooms have a pull out sofa bed and fully furnished. Furnishing consist of a full stove with oven, refrigerator , microwave, blender, coffeemaker, can opener, toaster, and all the necessary cooking utensils. There's a one bedroom private suites with it's separate entrance and stands on its own. It overlooking the pool and Jolly Harbour. It's fully furnished, including dish washer, jacuzzi jetted tub and a shower.
Guest has their own space, they do as they wish.


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South Arkansas Community College flight school
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Get the facts about South Arkansas Community College flight school, and registering for elective discussion sections and seminars. Which college degrees give you the best chances of finding employment after graduation? To earn a higher salary, compare accredited engineering concentrations, and research technical certificate programs in your chosen field. Concentrating on South Arkansas Community College flight school, for example, you may gain an advantage in corporate job recruiting on-campus. Check with the airline pilot training department for course registration deadlines, and flight training program requirements. Please use the form above to request admissions info for South Arkansas Community College.
Aerospace engineers may design aircraft, space vehicles, satellites, and missile systems. In addition, they test prototypes to make sure that they function according to design. Aerospace engineers are employed in building, analysis and design of commercial aircraft, missile systems for national defense, or spaceships. Aerospace engineers are employed primarily in manufacturing, research and development, and must have a bachelor's degree in aerospace engineering or another related field. In addition, aerospace engineers that work on projects that are related to national defense will need a security clearance.
Aerospace operations technicians and mechanics need only an associates degree to begin working. They must maintain equipment used in developing and testing new aircraft and spacecraft. Increasingly, these workers must be able to use computer-based modeling (CAD) and simulation tools in their work. Certification is offered by the Federal Aviation Administration (FAA). Both companies and the FAA seek to ensure the highest standards for the safety of the aircraft. In fact, SpaceTEC, the National Science Foundation Center for Aerospace Technical Education, coordinates a nationwide program through community and technical colleges to help students prepare for certification. The median annual wage for aerospace engineers with a bachelor's degree was $107,830, while aircraft technicians and mechanics holding an associate's degree earned $66,180, as of May 2017. Beyond major requirements within the airline pilot training department, you may consider University of Dallas sustainable energy as a complementary elective to your primary course of study.
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How to improve the tactical representation in the activity, "Bavaria" beneath Ancelotti?
Wager: System Success KF 2.1
Atlético – Sevilla
Start off by 18:00
"Idea" from the ultimate few flavor and attempt to relax the power connected with "really" along with "Barcelona" from the Pattern. The entire year or, the squad of Diego Simeone were able to become the safe bet in the nationwide finals. Shock as to the strike regarding Madrid brings much more plot in the contest, sitting on for the second the primary brand of the Speaking spanish championship. On the other hand, the next-door rival Barcelona contains a trump card as a single activity with stock options. Phenomenal performance Simeone can rely on achievements in the go with against Sevilla. In the last ten conferences atlético nine occasion permitted the sphere a winner, solely double letting in order to design her own web. Moreover, the past four sport, with January Oblak possesses guarded over a zero. "Katanacho" Diego Simeone doth the job great and also seldom "Seville" to "Vicente Calderon" some thing stands out.
The players connected with Unai emery ends up being in which the corner isn't going to slip, although take in air from the again "Eibar", went up for you to sixth spot. In the last eight goes with "Seville" indicated a significant beneficial result, shedding solely as soon as left to Granada (1:2). The majority of that aporia intended for Fernando Llorente along with match up To remain miles away coming from his or her "Ramon Sanchez Pishuan", wherever an individual basically was required to succeed the several things. Inside their final 5 apart complements the group Unai emery gets received in his purpose norm connected with 1.5 aims, along with undoubtedly that On the the communities will not completes without having a few goals report from the shift "plans".
Wagering: Get Atletico KF 1,6 / Atletico over (1.5 m) connected with KF regarding 1.95.
"Juventus" – "Roma"
Getting started – 22:45
Squad Massimiliano Allegri have fully overcome dormancy. Final 10 games inside championship for Juventus finished off only inside their prefer, thereby requiring themselves from the run after for the scudetto. This specific phenomenal spurt tolerated the squad via Turin nearly second room, diminishing the discrepancy with Napoli up to 2 direct. This specific effect Juventus hath a whole lot towards Argentinian Paulo Dibala – for the moment the most effective scorer with the players. At this point Diabalo with Moratai are pretty dangerous tandem with regard to keepers rivals.
But the party Luciano Spalletti, within the opposite, remains inside a ceremony of hung up computer animation, as precisely how in addition to help enlighten the final results in the end ten activity where the Romans made merely one Victoria. Very last meeting up with against trudging within the Get up with the "Verona" (1:1), the funding club seized on the "Olympic". In addition to the frankly poorly participated in opponent castan, exactly who gave a charges, Bosnian striker Dzeko frankly all messed up a couple of with the issue of "tete-a-tete". Junior in both instances became created by chief De Rossi may be the merely gambler inside the "wolves" that can produce something from the findings. On the other hand, over the following match scarcely this kind of must wait for. Roma get definitely observed, or else a slump, the dysfunction regarding crew participate in addition to you may anticipate how the Romans, inside a fight with a floating sack at every one storage container Juventus will Wake up the champion's instinct just isn't required.
Coaches in the big technology, particularly Italian, are often understood what conservative. Thus, sometimes they usually do not have to get employed to a brand new environment. Ancelotti – traditional. He has a lot in keeping with Guardiola – his or her goess always imbued with good deal connected with basketball ideas, but, contrary to the Spanish language coach, Carlo not too peculiar.
With his or her career, Ancelotti has a number of minutes of which ascertained his / her tactical strategies. Doing the job underneath the supervision involving Arrigo Sacchi, he or she appreciated that many team need to have personality knowning that big bang should always dominate. In Milan, Ancelotti heard a couple essential features – the quiet along with group way of remedying dilemmas. In addition, on the lessons Sacchi, he discover how the most crucial task around the ground enjoying midfield.


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Project awarded grant for neurological repair research
A grant from the National Institutes of Health (NIH) is to help researchers at Rosalind Franklin University of Medicine and Science, US, study how to replace neurons lost through traumatic brain disorders.
The five-year grant was recently awarded to Dr Daniel Peterson, director of the university's Center for Stem Cell and Regenerative Medicine, and Dr Robert Marr, Chicago Medical School associate professor of neuroscience, for the study 'Reprogramming Cell Fate for Repair,' a collaboration with co-principal investigators Dr Oliver Brüstle and Dr Martin Schwarz, at the University of Bonn in Germany.
Peterson said: "Our new reprogramming technology allows us to try to make neurons wherever they're needed in the brain for repair and we're having some success.
"What we're still trying to figure out is how to make enough of them and how to make them connect with the existing circuit."
Neurons in the brain and spinal cord are long-lived cells that are not replaced when damaged or lost. Recent advances in stem cell biology make it possible to introduce developmental genes into mature cells and direct them to becoming a different type of cell.
The study will use gene therapy approaches to directly reprogram rodent and human progenitor cells, which descend from stem cells to become neurons, and then evaluate the extent to which these newly engineered neurons connect with the rest of the brain.
The findings could lead to new therapies for neurological injury and disease such as stroke, spinal cord injury, and traumatic brain injury (TBI).
Peterson's team, which has also included researchers at DePaul University in Chicago, is investigating neuronal loss in an animal model of mild TBI with the goal of applying the reprogramming approach to replace lost neurons and restore function.


text:
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Spring Arbor University student directory
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Learn about Spring Arbor University student directory, and registering for discussion sections and departmental electives. As a student, your first stop should be the registrar's office, where you can pick up a free copy of both the academic calendar and course catalog, in order to find available credit classes that you may be interested in taking. Consult with an academic advisor, to ensure that your chosen classes constitute a full-time course load, and fulfills major requirements. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Spring Arbor University student life information. Please use the form above to request admissions info for Spring Arbor University.
Research demonstrates that college freshman taking a full courseload go on to complete their degrees at a much higher rate than those students who study part-time. When choosing a major, plan ahead and be sure that you are picking courses that will meet transfer requirements of other colleges and universities later on. Further, by choosing your major early, you may be able to take some required core classes in a community college, saving both time and tuition fees.
Look at all the schools in your state first, as in-state tuition may be lower for state residents. The course catalog will outline which classes are required for a particular major, and what minimum GPA you'll need to maintain your class standing. Please contact the academic advising staff at the school you are interested in applying to about their specific course registration guidelines. Beyond consideration for Spring Arbor University student directory, you may think about North Central Missouri College grade calculator for complementary electives to your primary course of study.
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text:
September 5, 2014 in News (E)
[prMac.com] New York, New York - India's leading publication house Malayala Manorama, brings its women's interest magazine; Vanitha, to the world's largest and fastest growing global digital newsstand and magazine store, Magzter. Malayala Manorama made the digital versions of its magazines available on Magzter last year, receiving great responses from global readers and now proceeds to reinforce its relationship with Magzter by adding on another popular publication, Vanitha.
A publishing stalwart in India, Malayala Manorama enjoys recognition and a fan following across the globe owing to its diverse, well packaged content, across various audience segments. The 21+ million user strong Magzter will now see a marked rise in users from India, the UAE, US and UK. Vanitha is published in Hindi and Malayalam. Although its name translates to "woman" in Malayalam, it includes articles on a variety of topics, and is not very strictly a women's magazine. Vanitha is also the largest circulated women's fortnightly in India. It is popularly considered a friend and guide to women, inspiring them to lead a better life through modern thinking and style.
"Malayala Manorama was quick to adopt digital publishing, setting a very progressive example for other publishers, especially in India, to follow. The group has a great collection of magazines and is globally known for their trend-setting content and publishing methods. We are very pleased to have Vanitha from Malayala Manorama available on Magzter." - said Girish Ramdas, CEO and Co-Founder, Magzter
"Publishers in India and across the world take inspiration in the success story of Malayala Manorama. The group has a keen eye for technology and ensures that it uses only the very best of this to create and publish its magazines. We welcome Vanitha to our newsstand. With publishers like Malayala Manorama helping to actively take Magzter's Go Green message forward universally, we are that much closer to a completely paper-free environment."- said Vijay Radhakrishnan, President and Co-Founder, Magzter
For more than a century Malayala Manorama has had a stimulating effect on the minds of the Malayali. It spurred social progress, defined cultural sensibilities, and even set political agenda. Malayala Manorama has publications in five languages, and from print they have also stepped into television and cyberspace. Today, it is a highly successful multi-magazine publishing house, bringing out immensely popular periodicals. The company has an impressive bag of about 25 publications, most of them leaders in their respective category which caters to the information and entertainment requirements of a large audience across various segments in India as well as ethnic Indian community groups elsewhere in the world.
Magzter counts among its publisher customers some marquee names including Hearst (USA), Conde Nast (USA), Newsweek (USA), AMI (USA), Dennis Publishing (UK), Haymarket (UK), Media24 (South Africa), Edipresse Asia (HK), India Today Group (India), WorldWide Media (India), Maxim Inc. (USA), Black Enterprise (USA), Singapore Press Holdings (Singapore), RBA (Spain), Grupo Expansion (MX), ePub Direct, Casemate Group, Ivy Press, Oxbow Books, AUK, Gill & McMillan, Westland, Arcturus Publishing Ltd, Osprey Group, Leadstart Publishing, Panoma Press and has been rapidly expanding its publisher base with magazines and books from more than 50 countries including USA, UK, Germany, Spain, China, Hong Kong, India, Indonesia, Mexico, Thailand, Philippines, Malaysia, Singapore, etc., making Magzter truly the #1 choice for book readers and publishers the world over.
Device Requirements:
* iPhone, iPad, and iPod touch
* Requires iOS 6.0 or later
Pricing and Availability:
Magzter - Magazine & Book Store 3.1.4 is free and available worldwide through the App Store in the News category. The annual subscription to Vanitha is priced at $9.99 (USD) on Magzter. The app is also available on Google Play, and Windows 8, the web, Amazon App Store and Kindle Fire and is expanding to more platforms soon. Users can buy their magazines on any of the above devices/platforms and seamlessly port their purchases to any other devices, a feature unique to Magzter.
Magzter Inc. is the world's largest and fastest growing self-service, cross-platform digital magazine store and newsstand with over 19 million digital consumers, more than 3500 magazines, 1000s of books and comic titles from over 1000 publishers. Headquartered in New York, Magzter has its local offices in London, Paris, Barcelona, Munich, Amsterdam, Cape Town, Chennai and Singapore and will soon be expanding to other countires. Founded by global entrepreneurs, Girish Ramdas and Vijayakumar Radhakrishnan in June 2011, Magzter enables magazine publishers around the world to create and deliver digital editions of their titles to global consumers. Powered by its proprietary OREY Click Publishing System(R), Magzter also enables their customers to publish interactive/audio-visual content in the magazine as it supports HTML 5. All Material and Software (C) Copyright 2014 Magzter Inc. All Rights Reserved. Apple, the Apple logo, iPhone, iPod and iPad are registered trademarks of Apple Inc. in the U.S. and/or other countries. Other trademarks and registered trademarks may be the property of their respective owners.


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Chevrolet Repair Questions? Ask a Chevy Mechanic for Answers ASAP
have you scanned it for trouble codes?
did they scan for history codes? it should retain in the system
The abs code should be stored they would need to use a abs capable scan tool..it should have a history code.. It sounds like a vehicle speed sensor failure..But scanning it just like a check engine light with the proper tool should show the fault
yes I would start there.......................
Please remember to only rate my service when you are satisfied. IF you feel the need to rate "Poor Service" or "Bad Service", please stop and reply to me via the REPLY TO EXPERT button with the issue you have. I will be happy to continue further and do everything I can to provide you with the service you seek.
I am not paid unless I get a rating of 3 to 5 Stars/Smiley Faces. If I have helped you with your question, please give me an appropriate rating so that I get credit for helping you
I would check the vss vehicle speed sensor


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trust deficit
when infidels are suspicious of mohammedans, as they hear or read about neighbors, colleagues, and friends who have gone to the middle east to fight with isis.
with rising radical islamism and terrorism worldwide, politically correct politicians daren't touch on the sensitive issue that the trust deficit between moderate muslims and believers of other faiths hasn't ceased to widen.
Read Also:
- shanjida
a very beautiful girl that has a 99.9% chance of stealing ur mans "hide ur boyfriend! i think i see -shanjida coming"
- pr*ng berry
a pr-ng berry is when a person is so constipated that they shove their hand up their -sshole and pull the p–p down the -n-l cavity jay had to pr-ng berry his way out of the bathroom today
- grope zoo
when multiple people will not stop petting or stroking you maybe your wearing a sweater with an interesting texture or maybe not maybe you have a cool fluffy hair style or one with tight curls but whatever the reason it's like a petting zoo with people that's gone to far oh my god stop touching […]
- taking the wog for a dalk
dead marriage or relationship, ho hum life sucking routine. example 1. " i think my relationship is over." "why you say that?" i told my wife i was taking the wog for a dalk and she said okay just try to be back by 6 it's tuesday tonight's salisbury steak ." example 2 dang man […]
- bed sap
the mixture of a girls v-g-n-l discharge and -n-l b-tter, blended up by the pounding of a males p-n-s, as it leaked onto the bed like sap from a tree "charmaine let the bed-sap drip out of you onto my leg"


text: Motorola Mobility will be splitting from Motorola, Inc. (NYSE:MOT) on the New York Stock Exchange starting January 4th. Shareholders in Motorola Inc. will get one share of every 8 Motorola Inc. shares they hold when the companies split. Motorola Mobility will trade under the symbol MMI on the NYSE. This transaction will be tax-free. The remainder of the company will be changing to Motorola Solutions, which will oversee the company's public safety and enterprise businesses. Stockholders will receive Motorola Mobility shares on December 21st. [Reuters]


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Hannover Messe
Established in 1947, Hannover Messe is the preferred venue for international product and technology premieres. It is held every April in Hannover, Germany. The upcoming edition will again gather the top industry trade fairs in one single multi-industry show where sustained business leads, broad media coverage and cross-industry knowledge transfer meet over 225,000 professional visitors and more than 5200 exhibitors from over 100 countries.
The main industrial fairs included in Hannover Messe exhibition are:
- Industrial Automation
- Energy
- MobiliTec
- Digital Factory
- Motion
- Drive & Automation
- Wind
- ComVac
- Surface Technology
- Industrial Supply
- Research & Technology
These shows represent the entire technology and industrial spectrum as well as digital and IT solutions and Analytical Research under one roof. Not surprisingly, Hannover Messe is considered a must visit event among professionals of all sectors. Get ready to experience the future trends and groundbreaking innovations that will drive the industry forward.
Hotels near Hannover Messe
- Direct contracts with a great variety of hotels
- Special exhibitor and visitor rates available
- Customised expo travel booking system
- Personal travel management at no extra cost
- Save on average €810 and 25 business hours per booked expo trip
Naturally, due to the immense popularity of Hannover Messe, most of the hotels in Hannover are fully booked for the event dates months in advance. For this reason we strongly advise early booking of hotel rooms. Our team secured contracts with many of the top hotels in the city, ensuring we can supply rooms to both large and small businesses attending the Hannover Messe.
Our experience in providing accommodation service for this event for the past 5 years, along with the professional approach of our dedicated travel agents team, ensures the best customer experience at the most affordable price. Send us a booking request or secure your hotel via our online reservation engine. Enjoy your success during the major trade fair that is Hannover Messe at no additional cost for you and your business.
Hotels for Hannover Messe 2018
|Kaiserhof Lehrte
|16 km
|From €283
|Wyndham Hannover Atrium
|9 km
|From €347
|Hotel Amadeus Hannover
|10 km
|From €144
|Van der Valk Hotel Hildesheim
|25 km
|From €379
|Domestic exhibitors
|2 184
|total: 6500
|Domestic visitors
|133 000
|total: 225 000
|Foreign exhibitors
|3 016
|Foreign visitors
|57 000
Venue: Hanover Fairgrounddetails
Founded in: 1947
Industry: Industrial Equipment, Maintenance
Frequency: every year
Where: Hannover, Germany
Organiser: Deutsche Messe AG
Travel Info For Hannover Messe
Airport: Hannover Airport 27.9 km
Railway station: Hannover Hauptbahnhof 8.6 km
Subway station: Hannover Messe/Laatzen 1 km
How to get to Hanover Fairground
By Rail
S-Bahn lines S4, S8 -> on station Hannover Messe/Laatzen and walk 10 minutes to the venue. In addition there are intercity express and regional express trains to this station.
- by tram
- rail lines R10 and R11 to Hannover Messe/Laatzen
- lines 8 and 18 to Messe Nord station
- lines 6 and 16 to Messe Ost station
By Bus
- use bus line 340 and 341 to Gutenbergstraße stop (south Messe area) or Hannover Messe/Laatzen stop (west 1 Messe area)
By Car
From motorways A7 and A2 take the exit to motorway A37, leading you directly to Hannover Messe. A total of 50,000 parking lots are spread around the venue.
- GPS coordinates: latitude 52.329319 ; longitude 9.809224
We can help with your airport transfer or Rent a Car in Hannover during Hannover Messeairport transfer or rent a car
Our Clients
Frau Dobreva hat super Arbeit geleistet. Immer schnelle Rückmeldung, sehr freundlich, sehr kompetent, immer wieder gerne. So macht es Spaß mit einer Agentur zusammen zu arbeiten. Mit Frau Dobreva haben Sie wirklich ein Goldstück!
A. Madejski
Booked for: dmexco 2017
You are an absolute star, Nelly, thank you for looking after us so well. I cannot thank you enough for securing us 5 extra rooms at the same hotel.
Jen Brown
Booked for: dmexco 2017
The service we received from Fair Point was fantastic. They were quick to respond to our (many!) questions, and were very accommodating when we had to keep changing our plans and had some very last-minute drop-outs/adds to attendees. I would absolutely work with them again in the future!
M. Wygand
Booked for: Bologna Children's Book Fair 2017
Nhat Huy Group
Excellent service which we will use again in the future. Thank you, Mr George!
D. Le
Booked for: ArabPlast 2017
Krishna Writing Instruments
We are happy with the services provided. Prices were competitive and services were good, without any confusion during check-in.
A. M. Agarwal
Booked for: Paperworld 2017
Amadeus Marketing GmbH
Der Fair Point Service war super. Es hat alles gepasst.
M. Parhofer
Booked for: EXPO REAL 2016
Minnesota Trade Office
Tanya Velikova from Fair Point was extraordinarily accommodating, patient and gracious with our requests as they developed and changed over the months.
S. Walbert
Booked for: Medica 2016
Exor International S.p.A.
Dear George, We would like to thank you for the great job you did for us. The hotel perfectly fitted all our requirements and needs in terms of subway service, near the center, etc... - thank you for the support on all of this. We'd already like to book rooms at the same hotel where we just stayed - would it be possible? I hope there is no problem.
G. Crivellaro
Booked for: SPS IPC Drives 2016
Orient Stone
I am very pleased with your professionalism and ability to solve all of the client's problems!
A. Melikyan
Booked for: Hannover Messe 2015


text:
Have a Tax Question? Ask a Tax Expert
Based on your information - you qualify for the exemption from sales tax as an occasional sale.See following documents posted by the comptroller
(a) Sales exempt. A taxable item that is sold or purchased by way of an occasional sale is exempt from sales and use taxes, except as provided by subsection (i) of this section.
b) Occasional sales by persons not in the business of selling, leasing, or renting.
(1) One or two sales of taxable items, other than an amusement service, during any 12-month period by a person who does not hold himself out as engaged (or who does not habitually engage) in the business of selling taxable items are occasional sales.
Following is the statement you need to submit
Please also see here
Occasional sales include:• one or two sales of taxable items, regardless of price, during any 12-month period (Texas Tax Code Section151.304(b)(1)); or• sales totaling up to $3,000 in a calendar year of items that were originally acquired for personal use by the personor a family member of the person selling them (Tax Code Section 151.304(b)(5)).
Let me know if you need any clarification this matter.


text:
A Day at NASA's Jet Propulsion Laboratory
This past week, one of my business partners and I had the pleasure of spending several hours with Steve Collins at NASA's JPL. I'm sure it would be fair to say that had I been able to see a reflection of myself, it would have been a mixture of a wide-eyed child trying to soak absolutely everything in with the ear-to-ear grin of someone who couldn't believe all of the real "fantasy-come-true" things he was seeing. That Steve, a completely down to Earth and plain-spoken, but insanely smart and accomplished…read more