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Paracelsus Elena Klinik Kassel
Paracelsus Elena Klinik Kassel
Shahnawaz M.,University of Houston |
Tokuda T.,Kyoto Prefectural University of Medicine |
Tokuda T.,Japan Agy For Med R And D Core Research For Evolutionary Medical Science And Technology |
Waraga M.,Higashi Matsudo Municipal Hospital |
And 8 more authors.
JAMA Neurology | Year: 2017
IMPORTANCE Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative disease associated with the accumulation of misfolded α-synuclein (αSyn) aggregates. An important problem in this disease is the lack of a sensitive, specific, and noninvasive biochemical diagnosis to help in clinical evaluation, monitoring of disease progression, and early differential diagnosis from related neurodegenerative diseases. OBJECTIVE To develop a novel assay with high sensitivity and specificity to detect small quantities of αSyn aggregates circulating in cerebrospinal fluid (CSF) of patients affected by PD and related synucleinopathies. DESIGN, SETTING, AND PARTICIPANTS The strategy evaluated in this proof-of-concept study uses the protein misfolding cyclic amplification (PMCA) technology that detects minute amounts of misfolded oligomers by taking advantage of their ability to nucleate further aggregation, enabling a very high amplification of the signal. The technology was first adapted with synthetic αSyn oligomers prepared in vitro and used to screen in 2 blinded cohorts of CSF samples from German and Japanese patients with PD (n = 76) and individuals serving as controls affected by other neurologic disorders (n = 65), neurodegenerative diseases (n = 18), and Alzheimer disease (n = 14). The kinetics of αSyn aggregation were measured by αSyn-PMCA in the presence of CSF samples from the participants to detect αSyn oligomeric seeds present in this biological fluid. The assays were conducted from November 15, 2013, to August 28, 2015. MAIN OUTCOMES AND MEASURES Kinetic parameters correlated with disease severity at the time of sample collection, measured by the Hoehn and Yahr scale, with the lowest grade indicating unilateral involvement with minimal or no functional impairment, and the highest grade defining patients with complete confinement to wheelchair or bed. RESULTS Studies with synthetic αSyn aggregates showed that αSyn-PMCA enabled to detect as little as 0.1 pg/mL of αSyn oligomers. The αSyn-PMCA signal was directly proportional to the amount of αSyn oligomers added to the reaction. A blinded study of CSF samples correctly identified patients affected by PD with an overall sensitivity of 88.5%(95%CI, 79.2%-94.6%) and specificity of 96.9% (95%CI, 89.3%-99.6%). The αSyn-PMCA results for different patients correlated with the severity of the clinical symptoms of PD (Japanese cohort: Rs=-0.54,P = .006; German cohort: Rs=-0.36, P = .02). CONCLUSIONS AND RELEVANCE The findings suggest that detection of αSyn oligomers by αSyn-PMCA in the CSF of patients affected by PD may offer a good opportunity for a sensitive and specific biochemical diagnosis of the disease. Further studies are needed to investigate the usefulness of αSyn-PMCA to monitor disease progression and for preclinical identification of patients who may develop PD. © 2017 American Medical Association.
Reichmann H.,Klinik fur Neurologie |
Deuschl G.,University of Kiel |
Riedel O.,TU Dresden |
Spottke A.,University of Bonn |
And 8 more authors.
MMW-Fortschritte der Medizin | Year: 2010
It is unknown, how frequently Parkinson's disease (PD) is complicated by dementia, depression and other neuropsychiatric conditions. An epidemiologic characterisation of the situation in specialised neurologic settings is lacking. The Geman Study on the Epidemiology of Parkinson's Disease with Dementia (GEPAD) is a national representative epidemiological study of n = 1,449 PD patients in n = 315 office-based neurological settings, designed to estimate the prevalence of dementia, depression and other neuropsychiatric conditions in patients with PD of all stages by using standardized clinical assessments. Results: 28.6% met DSM-IV criteria for dementia. 33.6% met criteria for depression and 61% additionally had other clinically significant psychopathological syndromes. Only 29.4% had no neuropsychiatric conditions. GEPAD reveals for the first time comprehensively that the neuropsychiatric burden of PD patients in all stages and even early stages is considerable, posing challenging questions for research and clinical management.
Krenzer M.,University of Marburg |
Oertel W.,University of Marburg |
Trenkwalder C.,Paracelsus Elena Klinik Kassel
Nervenarzt | Year: 2014
Restless legs syndrome (RLS) is the most common neurological sleep disorder affecting 10% of the Caucasian population. The disorder is characterized by painful sensations in the lower limbs, especially during the evening, at night and during rest, resulting in an urge to move the legs and insomnia. As a re sult the quality of life is significantly reduced. Dopaminergic agents, opioids and anticon vulsants have proven to be effective for RLS with only the former being currently licensed; however, affected patients have to be identified, which is not always the case, especially in outpatient settings. Possible impediments to the adequate management of patients with RLS may include a lack of awareness, comorbidities and other medical conditions mimicking RLS. To overcome some of these difficulties practical guidelines for the diagnosis and therapy of RLS are provided. © Springer-Verlag 2014.
Fuhs A.,University of Munster |
Bentama D.,University of Munster |
Antkowiak R.,University of Munster |
Mathis J.,University of Bern |
And 2 more authors.
PLoS ONE | Year: 2014
In a cohort study among 2751 members (71.5% females) of the German and Swiss RLS patient organizations changes in restless legs syndrome (RLS) severity over time was assessed and the impact on quality of life, sleep quality and depressive symptoms was analysed. A standard set of scales (RLS severity scale IRLS, SF-36, Pittsburgh Sleep Quality Index and the Centre for Epidemiologic Studies Depression Scale) in mailed questionnaires was repeatedly used to assess RLS severity and health status over time and a 7-day diary once to assess short-term variations. A clinically relevant change of the RLS severity was defined by a change of at least 5 points on the IRLS scale. During 36 months follow-up minimal improvement of RLS severity between assessments was observed. Men consistently reported higher severity scores. RLS severity increased with age reaching a plateau in the age group 45-54 years. During 3 years 60.2% of the participants had no relevant (65 points) change in RLS severity. RLS worsening was significantly related to an increase in depressive symptoms and a decrease in sleep quality and quality of life. The short-term variation showed distinctive circadian patterns with rhythm magnitudes strongly related to RLS severity. The majority of participants had a stable course of severe RLS over three years. An increase in RLS severity was accompanied by a small to moderate negative, a decrease by a small positive influence on quality of life, depressive symptoms and sleep quality.©2014 Fuhs et al.
PubMed | Paracelsus Elena Klinik Kassel and Vanderbilt University
Type: Journal Article | Journal: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine | Year: 2015
To clarify whether motor behaviors and/ or vocalizations during REM sleep, which do not yet fulfill diagnostic criteria for REM sleep behavior disorder (RBD) and were defined as REM sleep behavioral events (RBEs), correspond to dream enactments.13 subjects (10 patients with Parkinson disease [PD] and 3 healthy controls) originally identified with RBE in a prospective study (DeNoPa cohort) were reinvestigated 2 years later with 2 nights of video-supported polysomnography (vPSG). The first night was used for sleep parameter analysis. During the 2nd night, subjects were awakened and questioned for dream recall and dream content when purposeful motor behaviors and/or vocalizations became evident during REM sleep. REM sleep without atonia (RWA) was analyzed on chin EMG and the cutoff set at 18.2% as specific for RBD.At the time of this investigation 9 of 13 subjects with previous RBE were identified with RBD based upon clinical and EMG criteria. All recalled vivid dreams, and 7 subjects were able to describe dream content in detail. Four of 13 subjects with RBE showed RWA values below cutoff values for RBD. Three of these 4 subjects recalled having non-threatening dreams, and 2 (of these 3) were able to describe these dreams in detail.RBE with RWA below the RBD defining criteria correlate to dreaming in this selected cohort. There is evidence that RBEs are a precursor to RBD.
Doppler K.,University of Würzburg |
Ebert S.,University of Würzburg |
Uceyler N.,University of Würzburg |
Trenkwalder C.,Paracelsus Elena Klinik Kassel |
And 3 more authors.
Acta Neuropathologica | Year: 2014
The deposition of alpha-synuclein in the brain, the neuropathological hallmark of Parkinson's disease (PD), follows a distinct anatomical and temporal sequence. This study aimed to characterize alpha-synuclein deposition in cutaneous nerves from patients with PD. We further strived to explore whether peripheral nerve involvement is intrinsic to PD and reflective of known features of brain pathology, which could render it a useful tool for pathogenetic studies and pre-mortem histological diagnosis of PD. We obtained skin biopsies from the distal and proximal leg, back and finger of 31 PD patients and 35 controls and quantified the colocalization of phosphorylated alpha-synuclein in somatosensory and autonomic nerve fibers and the pattern of loss of different subtypes of dermal fibers. Deposits of phosphorylated alpha-synuclein were identified in 16/31 PD patients but in 0/35 controls (p < 0.0001). Quantification of nerve fibers revealed two types of peripheral neurodegeneration in PD: (1) a length-dependent reduction of intraepidermal small nerve fibers (p < 0.05) and (2) a severe non-length-dependent reduction of substance P-immunoreactive intraepidermal nerve fibers (p < 0.0001). The latter coincided with a more pronounced proximal manifestation of alpha-synuclein pathology in the skin. The histological changes did not correlate with markers of levodopa toxicity such as vitamin B12 deficiency. Our findings suggest that loss of peripheral nerve fibers is an intrinsic feature of PD and that peripheral nerve changes may reflect the two types of central alpha-synuclein-related PD pathology, namely neuronal death and axonal degeneration. Detection of phosphorylated alpha-synuclein in dermal nerve fibers might be a useful diagnostic test for PD with high specificity but low sensitivity. © 2014 The Author(s).


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just a few quick points that could help: you have several choices besides taking a variable as a factor. If the variable is very hard ro control but might have an influence on your outcome a possibility could be to record its values during the experiment and use it in the analysis as a covariate.Wome others vould be used as blocking variables, like possibly age of the material ( one block with aged and one block with younger material)? Others you might just randomize, according to the old DoE wisdom - block what you can and randomize what you can't.
More specifically 1. the best approach will depend on the number of factors you are left with. In general, you should plan a screening type of design first and adapt your experiment based on what you learn. A good rule of the thumb is to spend about 20% of your budget for the first run amd reserve the rest for follow-ups whete you will be a lot more informed. For screening designs I would always use two levels per factors, as I do not know yet which factors will be important, so there is a high risk of wasting runs.
2. That depends in theory on the effect size and the variation of you tesults. I personally prefer to run one replication first and get an upper limit on the effect size in case I find nothing. Then in the secon set of experiments we can decide to replicate the experiment and search for smaller effects or look somewhere else where we have a more promising situation.
kind regards and good luck


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Frederic: Director's Cut is an APk's Application free Download for android.
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Frederic Chopin – one of the world's most talented classical composers, is brought back from the afterlife and finds that he's an involuntary part of a treacherous plan. The world of music is at the edge of destruction. Soulless music labels and mass-produced popstars have hindered all creativity. And you're the only hope of bringing it back.
Accompany Chopin in his amazing journey full of quirky events. Battle your opponents in musical duels, intensity of which will make your palms sweat. Enjoy an hour of hand-drawn animated comic picturing the quirky story. Play through twelve catchy arrangements of Chopin's greatest classics, each in a different musical genre. Practice your skills until perfection and become the master of the piano.
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Jump Start [Bonus Tracks] [CD]
- Artist: Simon Says
- Release Date: 11/25/1999
Cardmember Offers
You need to install Flash Player to hear these tracks.
- Sever
- Slider
- Ship Jumper
- Life Jacket
- Nucleus
- Perfect Example
- On My Way
- Trip Wire
- Bold
- Seamless
- Act One
- Sam
- Quiet Time
- My Day
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At this time of the year, I often have to remind myself to be THANKFUL for all the annoying signs and phone calls.
They are evidence that we live in a free nation where we are free to run for office and to choose who will lead us.
I went to the polling place right after work and immediately saw a neighbor, a friend, an acquaintance, and a wonderful older man from our church.
I know two of the ladies who are running against each other for state rep (opposite parties) and I really like them both. Both live less than a mile from me.
I just love living in a small town like this. I wish you all could come live here and experience it with me.
Ok, well maybe not. Find your own small town. :P
Seriously, though - I voted.
Did you?
Copyright © 2010 - Paulla Estes


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- A. I. Presleni, E. V. Savvateeva, I. V. Peresleni, L. M. Sharagina
- Neuroscience and Behavioral Physiology
- 1997
P-insertion mutations were obtained and localized byin situ methods at the agnostic gene (agn: 1–38.9; 11AB) inDrosophila. All agn mutants showed a wide spectrum of pleiotropic effects: an EMS-induced mutation of the agn-ts398 improved the ability to develop a conditioned defensive response and increased the activity of cAMP metabolic enzymes; spontaneous… (More)
- L M Sharagina, E V Savvateeva, A A Atamanenko
- Genetika
- 1997
The activities of general phosphodiesterase and its Ca(2+)-calmodulin-independent from (PDE-1) were studied in strains mutant for the agnostic gene and in the strain Canton S. Enzyme activity was determined in males and homo- and hemizygous females of four strains. It was found that mutation at the agnostic gene resulted in increased PDE-1 activity. This… (More)
- E V Savvateeva-Popova, A I Peresleni, +8 authors M Heisenberg
- Zhurnal evoliutsionnoĭ biokhimii i fiziologii
- 2002
- S V Gasteva, T E Raĭze, L M Sharagina
- Patologicheskaia fiziologiia i èksperimental…
- 1986
- A I Peresleni, E V Savvateeva, I V Peresleni, L M Sharagina
- Fiziologicheskii zhurnal imeni I.M. Sechenova
- 1995
The ts-mutations of the agnostic gene either increased or decreased the activity of the AC and PDE. A chromosomal deficiency in the 11B region failed to complement with the agnostic behavioral defect like agn P29 and P40, led to an increased proportion of the PDE-1 in total PDE and to the structural defects in the central complex thus indicating that the P… (More)
- S. V. Gasteva, T. E. Raize, L. M. Sharagina
- Bulletin of Experimental Biology and Medicine
- 2004
The content and intensity of metabolism of phosphate groups of various phospholipids (phosphatidylcholines, monophophoinositides, aminophospholipids) were studied in homogenate, microsomes, and cytosol of the rat brain under normal conditions and in hypoxic hypoxia (240 mm Hg). The concentration of phospholipids per milligram protein was found to be highest… (More)
- S V Gasteva, O N Zamuruev, L M Sharagina
- Fiziologicheskiĭ zhurnal SSSR imeni I. M…
- 1979
Bilateral ligation of common carotid arteries sharply decreases volume blood flow and oxygen consumption in the cortex, in diencephalon and midbrain whereas inducing no changes in the cerebellum and medulla oblongata. The same is true for intensity of metabolism of both total and separate fractions of phospholipids. This suggests that the changes of… (More)
- N. G. Lopatina, L. M. Sharagina, E. G. Chesnokova
- Neuroscience and Behavioral Physiology
- 1995
This article provides a short summary of studies carried out on mutant Drosophila with defects in learning ability, including our own experimental data on the role of the tryptophan oxygenase gene (this is a key enzyme, and is the first enzyme in the tryptophan-ommochrome metabolic pathway) in the inherited determination of learning ability and memory in… (More)
- S V Gasteva, T E Raĭze, L M Sharagina
- Biulleten' eksperimental'noi biologii i meditsiny
- 1984
The rate of phospholipid turnover in brain subcellular fractions differ from that in the liver tissue. Hypoxia of medium severity (pressure chamber 240 mm Hg) influences neither the content nor the turnover rate of phospholipids in liver subcellular fractions. Meanwhile in brain subcellular fractions, it results in a decreased phospholipid turnover rate.… (More)
- S V Gasteva, T E Raĭze, L M Sharagina
- Biulleten' eksperimental'noĭ biologii i…
- 1978
The content and the intensity of metabolism of various phospholipid groups (phosphatidylcholines, monophosphoinositides, aminophospholipids) was studied in the homogenate, microsomes, and cytozol of the rat brain under normal conditions and in hypoxic hypoxia (240 mm Hg). Phospholipid content per 1 mg of protein was the highest in the microsomes, and the… (More)


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IBIS ROPPONGI 3 estrellas7-14-4, ROPPONGI, MINATO-KU, Tokyo, Japón
Información general
LOCATION : The hotel is situated in the heart of the Roppongi area, just one minute walk from Roppongi Station. All major Tokyo sightseeing places can be easily accessed within 30 minutes by subway lines. ROOMS : The rooms are medium in size and decorated in a modern style with pastel colours. The rooms and the bathrooms are in good condition. RESTAURANT : The hotel offers 4 restaurants with a variety of cuisine and atmosphere. The famous Italian Ristorante SABATINI is located on top floor of the hotel. The menu they provided is exactly same as the one at SABATINI in Rome. Also every piece of furniture, tableware, silverware, wine selections and ingredients are imported from Rome. Guest can enjoy fantastic meal in superb atmosphere and the bustling Roppongi night views. EXTERIOR : The hotel is a 13-storey modern concrete building in light brown in colour. LOBBY : The lobby is small in size but decorated with an attractive marble. A small resting area is located within the lobby. GENERAL : Roppongi is a town where the old and the new coexist. Stand at the Roppongi intersection for a while and you will see how international the town is. The numerous embassies in the vicinity are what make Roppongi international. The food, fashion, household goods and music stores are quick to catch the latest trends from abroad. The number of ethnic restaurants have been increasing every year, and Roppongi has become the international gourmet centre of Tokyo. (1005YS). (c) Donvand Limited 2006
¿Quieres alojarte en el IBIS ROPPONGI al mejor precio?
- Restaurante


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You have no discounts. Click here to get some.
I noticed Brandon Lang is hyping up this super bowl saying this is the 2nd biggest release of his life. I am not trusting to roll with him again as I did in the past. I would though be interested on who he is on so I could go the other way.
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200 dimes Baltimore
F--- Brandon Lang!
"If you want good service- serve yourself." There are plenty of really good cappers here on Pregame who I would consider way before looking to some overblown hack.
Is brandon Lang and Andrew Lang the same person??
Your share has been sent.


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Jim Sutton speech to Vet Assoc
Jim Sutton speech to Vet Assoc
Joint NZ Veterinarian Association and Commonwealth Veterinarian Association meeting, Wellington
Ladies and Gentlemen: thank you for the invitation to speak at your conference today. I am delighted to do so, because veterinarians play a vital role in our economy.
I am pleased to see animal welfare along with other strategically important issues of biosecurity and food safety as themes of your conference.
As people who choose to work with animals in a healing role, one would expect vets to have a strong personal commitment to animal welfare. As a profession, you play an important role in animal welfare within New Zealand, the Commonwealth, and internationally.
As a food producing nation, animal welfare is a serious issue for New Zealand.
Happy animals are more productive, and there is a consumer demand to make sure animals lead happy lives before they become food.
Internationally, there are some who believe that the production of food is special. That it is not like the production of other things, say: coal, or steel. I am not so sure about that. Farming is a business, albeit one that is perhaps more at the vagaries of the weather than other businesses.
However, it is increasingly important to think about these issues, as they could have ramifications within the international trading system.
I spend the majority of my time at the moment on work in my trade negotiations portfolio, especially as we build up to one of the important meetings in the World Trade Organisation negotiations underway at the moment.
These negotiations have huge potential for New Zealand, and other nations throughout the world.
A study published last month jointly by our Foreign Affairs and Trade Ministry and the Agriculture and Forestry Ministry indicates that the trade liberalisation measures agreed to in the WTO's last big trade round, the Uruguay Round, were worth at least $9 billion to New Zealand over the 10 year implementation period. That's a lot of money in anyone's language.
But the Uruguay Round was only a toe in the door, for agriculture.
The Doha Development Round has even greater potential.
So that's why this Government is putting extra resources into trade negotiations. That's why I and numerous trade officials are spending so much time overseas at meetings where trade liberalisation is slowly making progress.
Sometimes it seems that progress in trade liberalisation is always some way away in the distance. But signs are that we will make progress in the World Trade Organisation negotiations currently underway.
How do I know?
The tomtoms are beating in Europe with concerns about our animal welfare and environmental standards.
As the pressure goes on European farmers to change their decades-old reliance on export subsidies and the like, they will search for other ways to keep us out of what they think should be exclusively their markets. They will start applying more and more pressure on us to meet nitpickingly high standards in non-trade areas.
New Zealand dairy farmers are already seeing that, with European farmers at a recent conference criticising us for leaving cattle outside where they might get sunburnt and making them walk twice a day to milking sheds, risking chafing to their udders.
Those criticisms are unjustified, but it points to the way things will increasingly go in the future.
More and more, our exporters have to seek to demonstrate to retailers and consumers that our products meet their expectations for animal welfare standards, and thus command premium prices.
The influence of retailers and consumers in Europe as drivers behind new and stronger animal welfare standards should not be understated, although there is often a dichotomy between the canvassed views of consumers and their willingness to actually pay for the additional costs of these increasingly higher animal welfare standards.
Despite that, civil society groups will share internationally animal welfare campaigns they operate with a considerable degree of success. It is not hard to drum up sympathy for chickens, pigs, and other food animals in societies where the mainly urban populations are significantly divorced from and ignorant of the realities about where their food comes from. When you are brought up with bunny rabbits running round the edge of your porrige plate, weaned on Peter Rabbit stories, and grow up to "Watership Down", you are not instinctively a support of rabbit pest management strategies.
It is in New Zealand's wider trade interests to continue to position ourselves as hiaving progressive animal welfare policies and to actively participate in international fora.
New Zealand is recognised internationally as being a high performer in animal welfare, with modern animal welfare legislation, a strong animal welfare science capability, and a cohesive national animal welfare infrastructure.
As part of the Animal Welfare Act 1999, codes of welfare with legal standing for animals are being introduced. These codes replace earlier voluntary codes which set out minimum standards and recommended best practices for animals owned or in a person's charge.
The voluntary codes are currently being revised as part of the transition to the new system.
The first new code to be issued under this new system is the code of welfare for broiler chickens. These chickens are chickens kept primarily for meat production ? the ones that end up barbequed in your local supermarket.
This code, the Animal Welfare (Broiler Chickens: Fully Housed) Code of Welfare 2003, covers the welfare of broiler chickens in controlled environment brioler production systems. In such systems, broiler chickens are kept in enclosed housing and are reliant on human management for all their daily needs.
This has not been an easy process, and it has taken considerable time. The drafting process requires consultation with "representatives of those most likely to be affected by it", which in this case included animal welfare organisations such as the SPCA, the New Zealand Veterinary Association, and the broiler industry.
I have signed off the code, and it was gazetted on Wednesday. It will come into force on July 25.
This code is not the final word on the issue. NAWAC have asked for research on broiler chickens' welfare to be carried out. MAF have this in train. As more information comes to hand, it will be added to the process and the code will be reviewed at regular opportunities.
The work of veterinarians is a key part of our animal welfare system, and I want to recognise that this morning. Thank you, ladies and gentlemen.
We are also recognising an individual talent today.
It is my honour to present Dr Lindsay Ross Matthews with a New Zealand Science and Technology Bronze Medal 2002 for his significant contribution to the understanding of animal behaviour and animal welfare in agriculture and in nature.
These medals were instituted by the Royal Society of New Zealand to recognise those who have made exceptional contributions to New Zealand society and culture, beyond the bounds of the discipline or immediate work environment.
With more than 100 refereed publications, Dr Matthews has made a sustained and valuable contribution to the understanding of the behaviour of animals under domestication and in the wild over many years. As a researcher, a developer of technologies, and a communicator, he has contributed to the welfare of agricultural animals on a wide scale, with substantial benefits to both animals and farmers, and hence to the economy in general.
Dr Matthews has a bachelor of science from Auckland University, as well as a first class masters degree and PhD from Waikato University. As well as serving on the National Animal Welfare Advisory Committee for six years, Dr Matthews has been a member of the Animal Behaviour and Welfare Consultative Committee since its formation. He has been at the Ruakura Agricultural Centre since 1989, and currently holds a team leader position within the centre.
Dr Matthews, thank you for your contribution and congratulations.


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By Karen Lehrman Bloch
The encouraged domestic: Interiors of Deep Beauty opens the door to 25 of the main appealing houses within the world—ones owned by means of most sensible inside designers, type designers, artists, and stylists—to show how basic ideas borrowed from nature can encourage attractive, leading edge interiors that either calm and embolden us.
To create this special quantity, Karen Lehrman Bloch interviewed popular aesthetes with houses around the world, together with inside designers Juan Montoya, Darryl Carter, and Vicente Wolf; style designers Donna Karan, Alberta Ferretti, and Consuelo Castiglioni; stylist Lori Goldstein; and artist Michele Oka Doner.
The direct and useful recommendation featured inside of, besides a wealth of amazing images of the houses, teaches us how one can think visually, comprehend colour and texture, and locate gadgets, new and used, with a feeling of lifestyles. An encouraged domestic, Bloch unearths, fulfills our actual and religious wishes, offers an everlasting feel of rejuvenation and delight, and is either simply possible and timeless.
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- Google SketchUp: The Missing Manual
Extra resources for The Inspired Home: Interiors of Deep Beauty
On the different severe, many folks are so interested in making a domestic that feels of the instant that we frequently fill it with items which are way more attracted to getting realization than stirring us emotionally. those items should be momentarily compelling, yet you'll likely quickly tire of them. really undying homes—like those during this book—will proceed to appear and believe as clean and colourful because the day they have been created. Why? simply because they comprise items, either previous and new, which are good grounded in nature's ideas, and as the items have then been innovatively merged to create compositions that flow the trajectory of good looks ahead. brain, physique, SPIRIT, variety making a soulful, inspiring house is the more durable street. It's loads more straightforward to determine a room in and simply replica it. to shop for a piece of artwork or piece of furnishings simply because a decorator says it's glamorous. To insulate ourselves from our individuality and our emotions. but when we pass down this road—if we really attach our type with our identities and our emotions—we will continuously be rewarded with a deep experience of enjoyment from the environment. It's most likely unfair to claim that purely the weather of nature can actually nourish the soul, yet there's definitely sufficient facts to indicate that those parts are the main accessible—and direct—means hence. they could educate us the way to reside a extra significant lifestyles, one during which we now not think liable to each bump and quandary that might necessarily come our means. they could aid us in attaining no longer a superficial happiness according to express and inform yet a deep, sustained happiness rooted in our individuality. I selected the houses during this ebook simply because they motivate me—and my wish is they will motivate you. in fact, we every one have our personal area obstacles, let alone our detailed tastes. yet my desire is that via this ebook you are going to start to see a connection among the place you reside and the way you're feeling, and that you're going to start to take into consideration sort in a extra substantial method. ONE AUTHENTICITY A poultry will get up each morning and sings its tune. It doesn't wait to listen to what different birds are making a song, nor does it glance to determine if one other poultry is getting extra realize. It is aware its track innately and sings. this can be nature: understanding your personal track. —MICHELE OKA DONER An African musical software within the entryway of James Cavagnari's domestic. you're the artist of your place. That's it: that's on the middle of making an inside with deep good looks. you begin with a completely clean canvas—no preconceived principles of what your place "should" glance like—and a very large palette of colours, textures, sessions, and cultures. after which you must upload in what's probably the main tough aspect: the boldness to create whatever you've by no means obvious ahead of. each side of nature is either targeted and comfortable in its personal dermis. each point of your house may still consider like an extension of your character. the times of "following"—following culture, developments, the private aesthetic of a decorator—are over.


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I had no intention of starting a new project tonight, quite the opposite in fact. The game plan for tonight was to get stuck into one or maybe two of the unfinished sewing projects hanging about in my lounge room. I had visions of stumbling across a finish line. 'Twas not to be.
The day had slipped blissfully by as I soaked up the summer's end. Tired and hungry, in that good fresh air and sunshine kind of way, I flopped on the couch after finally getting the children off to bed. The two and half year old was less than agreeable in this regard but those laments can be saved for another time. Sewing was not to be. The pink project I was telling you about yesterday is in pieces pinned to a towel, a lame gesture of blocking and yet significantly more effort has been invested than is the norm.
Couch craft was calling. The 5mm sticks were located, as were some yarny remnants (or are they scraps?) and some stitching was undertaken. A movie has been watched. The small scale project is almost finished, perhaps I may fall over a finish line after all? Off to watch Episode 1 Season 2 of Breaking Bad as I knit a few more rows…
Linking up with Kirsty's Creative Space.


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These truly original menu covers from Menushop combine a hard wearing and ever popular wooden cover with a stylish cutout showing a personalised mirror finish metal print underneath. Each cover is available in either a light or dark finish that can be fret cut in almost any design.
The backing that is visible through the cutout is attached to the inside cover and can be printed in any design or colour on polished gold, silver or white metal. The interior features a fixed corner mount to match your chosen spine on the inside front cover (see picture 18), this can also be added to the inside back cover.
If the thought of coming up with an original design for your business is too daunting, let us do it! Provide us with text, a logo or image in as high a resolution as possible and we'll do the rest for a one off setup charge.
Please note there is a minimum order quantity of 10 menu covers
If you have old wooden menus and think they need updating why not call us first and see what we offer in terms of refurbishment options. Often for a minimal cost we can extend the life of your menus with replacement spines and optional corner protectors.
|Menu Cover Sizes
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|A4 all options
|Slim Clear Pockets
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|130 x 297mm
|Slim raised corner mount
|130 x 297mm
The overall size of your menu is dependent on your
choice of inserts. For exact sizes please contact us.
Each cover uses a combination of personalised wood cutout with a printed background on polished gold, silver or white metal. One off setup cost £40
(Subject to sight of artwork minimum order quantity 10 menus)
Your order will be despatched within 15 working days.
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Modelling labour market dynamics with on-the-job search
A flow model of the Dutch labour market is used to calculate the effects of policy options which aim to enhance employment, especially at the lower end of the labour market. The model distinguishes between good and bad jobs, allows for endogenous wage formation and job creation, and describes the flows between these jobs so that job-to-job mobility and the vacancy chain is made endogenous. In the matching process employed job seekers with bad jobs compete with short-term and long-term unemployed for the filling of vacancies for good jobs. In each period part of the good and bad jobs are destroyed which results in inflow into unemployment. The model explicitly describes the flow of unemployed through the various duration classes of unemployment and it allows for negative duration dependence so that the escape probability from unemployment for long-term unemployed is smaller than for short-term unemployed. The model is used to simulate the effects of external shocks, such as structural productivity shocks. An impulse response analysis using the model is also conducted considering labour market policies which aims especially to enhance employment at the lower end of the labour market. In particular, the effects are analyzed of measures subsidising the opening of bad jobs (jobs at the lower end of the labour market) and a rise in the productivity of a bad job as compared to a good job which can be achieved by changes in the tax system.
(This abstract was borrowed from another version of this item.)
If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.
As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.
Volume (Year): 16 (1999)
Issue (Month): 4 (December)
Pages: 545-567
|Contact details of provider:
| Web page: http://www.elsevier.com/locate/inca/30411
References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
- Daniel S. Hamermesh & Wolter H. J. Hassink & Jan C. Van Ours, 1996.
"Job Turnover and Labor Turnover: A taxinomy of Employment Dynamics,"
Annals of Economics and Statistics,
GENES, issue 41-42, pages 21-40.
- Hamermesh, D.S. & Hassink, W.H.J. & van Ours, J.C., 1996. "Job turnover and labor turnover : A taxonomy of employment dynamics," Other publications TiSEM 1f3fab1f-b02a-485a-bb8f-f, Tilburg University, School of Economics and Management.
- Olivier Jean Blanchard & Peter Diamond, 1994. "Ranking, Unemployment Duration, and Wages," Review of Economic Studies, Oxford University Press, vol. 61(3), pages 417-434.
- Olivier Jean Blanchard & Peter Diamond, 1990. "Ranking, Unemployment Duration, and Wages," NBER Working Papers 3387, National Bureau of Economic Research, Inc.
- Blanchard, O.J. & Diamond, P., 1990. "Ranking, Unemployment Duration, And Wages," Working papers 546, Massachusetts Institute of Technology (MIT), Department of Economics.
- Christopher A. Pissarides, 1994. "Search Unemployment with On-the-job Search," Review of Economic Studies, Oxford University Press, vol. 61(3), pages 457-475.
- Gerard J. van den Berg, 1990. "Nonstationarity in Job Search Theory," Review of Economic Studies, Oxford University Press, vol. 57(2), pages 255-277.
- van den Berg, G., 1987. "Nonstationarity in job search theory," Research Memorandum c2b931bf-9cce-4bae-929c-b, Tilburg University, School of Economics and Management.
- van Ours, J.C. & Gorter, C., 1994. "Matching unemployment and vacancies in regional labour markets; An empirical analysis for the Netherlands," Other publications TiSEM 63318c4d-4008-4f29-94eb-a, Tilburg University, School of Economics and Management.
- van Ours, J. C., 1991. "The efficiency of the Dutch labour market in matching unemployment and vacancies," Other publications TiSEM 4bbea82e-68fb-45e0-b32a-3, Tilburg University, School of Economics and Management.
- Broersma, L. & Butter, F.A.G. den, 1994. "A consistent set of time series data on labour market flows for the Netherlands," Serie Research Memoranda 0043, VU University Amsterdam, Faculty of Economics, Business Administration and Econometrics.
- Oliver Jean Blanchard & Peter Diamond, 1989. "The Beveridge Curve," Brookings Papers on Economic Activity, Economic Studies Program, The Brookings Institution, vol. 20(1), pages 1-76.
- Gautier, P.A. & Butter, F.A.G. den, 1995. "Structural change and wage formation in an empirical flow model for the labour market," Serie Research Memoranda 0039, VU University Amsterdam, Faculty of Economics, Business Administration and Econometrics. Full references (including those not matched with items on IDEAS)This information is provided to you by IDEAS at the Research Division of the Federal Reserve Bank of St. Louis using RePEc data.


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Chad Greenway on Whey Protein and a Healthy Lifestyle
I think when it became my job to only playfootball, that was my job.
You know this is my career.
I want to make it as long as Ican make it.
You know then it was important for me to find out the best way to do that.
It's important for my nutrition to eat clean, to eat healthy, because I'm going to feelgood.
But I think when you add a great whey protein isolate like this.
It almost pushesyou into hey I'm going to make a better choice.
I'm not going to get fries at this meal.
I'mgoing to get something better, because it makes you feel that way and so I think it'sa whole lifestyle in general.
This is what I get paid to do and this is what I do andwant to do as well and as long as I can and this whey protein isolate is going to helpme do that, but if your the general public and you want to have a healthy lifestyle andyou are working out, trying to make that work for you.
This is going to push you into ahealthy realm.
You know, you're going to get the workout in, recover, you're going to feelbetter, have more energy, and you are going to want to keep doing that everyday, everydayand eventually, you know, you lose those pounds maybe you need to lose or you're feeling better,having more energy.
You know, so it can help you in so many different ways.
Source: Youtube


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The handsome lads discuss the state of Purdue football, the start of Purdue basketball and maybe a little bit about fallen racer Dan Wheldon.
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This program connects you to www.OneSearch.mobi This is an extensive mobile directory with TV/Videos/Music downloads and other services.
Freeware - Download PocketPC MobileOnesearch© Now!
To run these Pocket Visual Basic programs you need the free Microsoft Distribution Source Files located at http://www.CeBeans.com/runtime/runtime.htm
Click here to go to the Free Windows CE Software Website
(c)1998-2008 Vincent Collura ( Inventor / Engineer )


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Marion Technical College double major
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Learn about Marion Technical College double major, and registering for elective seminars and lectures. As a student, your first stop should be the registrar's office, where you can pick up a free copy of both the academic calendar and course catalog, in order to find available credit classes that you may be interested in taking. Then get a copy of the schedule of classes, so you can plan a workable weekly schedule for yourself. Finally, check with the admissions office for assistance with prerequisites, tuition payment deadlines, and Marion Technical College major requirement information. Please use the form above to request admissions info for Marion Technical College.
Given the large number of colleges, universities, and vocational training programs, how can you make a wise choice, in oder to select the school that's best for you? Of degree-granting schools, over 1,600 award associate degrees and 2,400 award bachelors degrees. By asking youself several important questions, you can narrow down the list to a reasonable size. Many students choose a college nearby, not only to save money on in-state tuition, but to remain close to family and friends. If you're looking further afield, ask yourself what you want to achieve long-term, and don't start college hoping you'll figure out what major to choose later.
By looking over the course catalog from any major university, you can get an idea which courses are going to be required in a given major. Try to remember how you felt when you took related subjects during high school, and ask yourself if you would look forward to several years of in-depth involvement and study in that field. If you're lucky enough to know what direction you want to take, then college rankings can help you define your options, based on your GPA, class standing, extracurriculars, and test scores. Beyond degree requirements such as Marion Technical College course registration, you may consider Marymount Manhattan College auditing classes for complementary electives to your primary course of study.
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To try the thousands of add-ons available here, download Mozilla Firefox, a fast, free way to surf the Web!Close
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Choose from thousands of extra features and styles to make Firefox your own.Close
Review for RequestPolicy by Aleksej
Rated 4 out of 5 stars
Very good, but an important thing is missing - wildcard or regexp support, so you can use the full address mode for unfamiliar sites or untrusted subdomains, but don't have to add many permissions for trusted sites and subdomains. Blocking an untrusted subdomain might require a blacklist though.This review is for a previous version of the add-on (0.5.13).
To create your own collections, you must have a Mozilla Add-ons account.


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The purpose of this conference is to offer opportunities for nursing professionals, involved in the health care of infants, children and adolescents to learn about current trends and advances in pediatric care and to network with colleagues in primary care and specialty care.
Considering hiring a new babysitter? Enroll him or her in this class to encourage the best care for your child.
This course is designed to highlight advances in pediatric trauma care. It will help pediatric providers to identify, stabilize and appropriately manage pediatric trauma patients using mechanism & patterns of injury to guide evaluation.
This class is taught by a St. Louis Children's Hospital registered nurse who uses the American Heart Association's video-led curriculum, which includes hands-on skills practice and a 65-page student manual. This class does not include certification.
This parent/child program will help you determine when your child is prepared to stay home alone and will help prepare them for this experience. Parents and children must attend together.
For one night, adults are invited to be kids again.


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New Look Sewing Pattern 6398 Size A (2-3-4-5-6-7)
List Price: unavailable
Sale Price: $11.50
Availability: unspecified
Product Description
Unisex Child's Top, Pants, Shorts, Skirt and Reversible Jacket and Vest sewing pattern. New Look pattern 6398, part of New Look Summer 1995 Collection. Pattern for 6 looks. For sizes A (2-3-4-5-6-7).
- in size A (2-3-4-5-6-7), New Look Pattern #6398
- Number of looks included: 6
- Designed in UK, Manufactured in USA
- Instructions are written in English, Spanish, and French
- Children's apparel sewing pattern


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The Selfie Toaster
How much do you love taking selfies? I mean let's be honest, it's 2016 so who hasn't taken a few pictures of themselves? If you want to glorify the picture of your beautiful face even more than you already do then you should buy the Selfie Toaster. Snap a pic of yourself and burn it into all the pieces of toast you make! Next time you host a family breakfast you could watch your family chew away at your selfie!


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I have stopped taking my multivitamin.
For the most part I have tried to take one daily over the years. I've tried taking one with food, without food, in the morning, at night. Most of the time I get sick to my stomach. I've never thrown up from the multivitamin but I would get that nauseous feeling, stop dead in my tracks and plead for it to pass.
I don't know why it took me so long to get fed up with this uncomfortable feeling but one day recently I went on Google and typed in "vitamin making me sick." Within seconds I had found an answer. It's the iron in the pill. It was too much for my system and making my stomach upset.
I didn't want to stop with Dr. Google so I asked my family doctor recently and she immediate said, "If it's making you feel sick, don't take it." Because I have a well-balanced diet and regularly eat fruits and vegetables, she said I should be fine without taking a multivitamin. Whew!
So I tossed these last night. I also realized they expired in January 2012 (whoops)! Cleveland folks will also notice that I bought these before we moved because there are no Kroger stores in Cleveland. Instead I am going to say hello to these two.
I had my blood tested this month and I was in the 'insufficient range' for Vitamin D. It's Cleveland. It's January. No shocker, my doctor said. So she did recommend I take Nature Made Vitamin D daily at least in the winter.
In addition I bought some fish oil. I've long read the touted health benefits of Omega-3, but I couldn't stomach the massive liquid filled pills. I found this new product, Nature Made Adult Fish Oil Gummies, and decided to give it a try.
Do you take a multivitamin? Why or why not?


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Removes dust, dirt, lint and other particles that settle on wood. Helps achieve super smooth surfaces. Single ply cloth, 612 square inches. Rental.
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Kenna James is young and undeniably gorgeous. She is also the February 2015 Penthouse Pet. The slender 19-year-old poses in denim that she is eager to strip out of. Her jean jacket is already unbuttoned and she pulls it open to show off her small breasts. Her skimpy shorts are not zipped and she teasingly slides them down to reveal the perky curve of her flawless butt. The honey haired ingenue managed to have you gazing at her angelic face every bit as much as her tight body.
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How To Promote Your Brick-and-Mortar Store Online
The internet is the golden goose of our time. It is estimated to be responsible for billions of dollars of transactions of online purchases every year. So naturally, those with entrepreneurial spirit may be inclined to focus the majority of their efforts into creating an e-store, rather than using the internet to promote their brick-and-mortar store.
Running an online store may be a great way to keep overhead costs low and expand market share to the global market, however not every business is suitable for e-commerce. Businesses that are focused on the local market, whether it is a local service that is being provided or products that are being sold, may find they have more success if they use the internet as a tool to promote their local business rather than a way to sell their products or services.
Although not as recognized, the internet is also responsible for billions of dollars of offline sales each year. There is a large sub-group of internet shoppers, referred to as off-channel or web-to-store shoppers, who use the internet solely for research on products and services they are looking to purchase in a local brick-and-mortar store.
In order to be successful with your brick-and-mortar store you really need to set up an online presence that caters to this sub-group of consumers. The following are some tips to help you promote your brick-and-mortar store online:
Domain Name
Your domain name is your website address. When deciding on a name it is important to choose a domain name that is short and memorable enough that potential customers will be able to remember, and find, your website from any of your traditional offline promotions, such as television, radio and newspaper ads.
It is worth the investment to hire a professional web designer to create a website that is clean, easy to navigate and provides all the necessary information, such as store location, contact information, times of operation, and product information. If it is reasonable to do so, you may even want to include an e-cart to handle any purchase requests you may get from online visitors.
Online Coupons
Offering online coupons or discounts that are available for in store purchases is a great way to track how effective your website really is. Coupons and discounts may even further influence potential customers who are visiting your website to perform some product research to visit your store.
Another component of your website that will help to promote your brick-and-mortar store online is a company blog. This is a great way to explain your products and services in more detail, promote any upcoming promotional events, and develop a following of readers and loyal customers.
SEO, SEM, Social Media
Having a website and blog alone is only one piece of the puzzle. It is a great start to promote your store online, but if no one is following your website your reach can only go so far. This is where SEO (search engine optimization), SEM (search engine marketing) and Social Media come into play. SEO deals with optimizing your website for a specific market through its content. SEM deals with marketing your website online through such things as paid advertising. And Social Media involves using such social sites as Facebook, twitter, Google+, Yelp, etc. SEO, SEM and Social Media can be used on their own, but in general it is best to develop an overall marketing package that includes all three.
Overall, in order to promote your business online you will need a memorable web address, and clean and easy to navigate website and some interesting content that can be shared through social media. The important thing is to have fun with it and be as real and natural as you are with your in-store customers.
Filed under Information Articles, Small Business, Starting A Business by


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Manager – Sales and Marketing ( Smart Communications) (Kolkata)
Employer: Shivam Knowledge Solutions Private Limited
Industry: Management, Marketing & PR
Location: India, Kolkata
Company Profile
Shivam Knowledge Solutions Private Limited Established in 2011, we are one of the Leading HR Consulting , Staffing , Training and Services Organizations in India. We are recruiting for our new vertical in IT Products and Smart Communication Services. Download PPT Photo 1
Job Description
– Leading the Marketing Team for Sales of Smart Communication Solutions to Schools.
– Strategize and implement B2B Sales and Marketing.
– Must be able to work with targets and achieve results Sales , Retail , Business Development Any Graduate – Any Specialization Any Postgraduate
– Any Specialization Retail Sales Sales/Business Development Manager
– Must have excellent Managerial Skills
– Must be proficient in use of internet, mobile devices and apps.
– Must be Tech Savvy and comfortable with modern Digital Devices and Communications
Send your CVs to [javascript protected email address]


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I Want To Give In Again (venting A Little And A Poem)I 'quit' a year and a half ago. Gave in again exactly a week ago. I told myself I wouldnt again. I cant go down that path. It's too hard to hide. Its self destructive. I can't break that promise I made to myself again. I cant break the promise I made to others again. I can't give in. I'm stronger than this addiction!!!!!
Or am I?
Pain has struck again, and I just long for the cut. I long to bleed. I long to take the easy way and just cut. Bleeding always helps. Even if I hate myself after, the pain it relieves makes it worth it.
But I can't.
I was so proud when I reached a year and 6 months. I felt so disappointed in myself 2 days later when I broke that streak.
I can't give in.
But the need is so strong. Gah.
I look at the cuts from a week ago,
they're starting to fade.
I want to make them new
make them red
make them flow.
The pain is coming up
as they are fading.
I need the stripes
I need the scars
I need the bloody sea.
I scratch at them
to see if I can even get the pain.
It's gone.
They do nothing for me anymore.
I look at all my scars,
all 82 of them.
82 freaking scars.
And 5 new cuts.
Isn't that enough?
haven't I mutilated my body enough?
Why am I not satisfied?
Are the scars too small?
Are they too old?
Why can't the pain go away?
Why must it TORTURE me?
My life isn't that bad.
Sure, I have stress
Sure, I'm a mom to my own damn mother.
Sure I hate her boyfriend
Sure, school is stressful
Sure, I hate my 'friends'
Sure, I hate everyone who lies about caring
But it's not that much.
I can handle it.
I can.
I'm strong, not weak.
I can.. I WILL survive.
I am stronger than this addiction!
But the knife just stares at me
Smiling at me with its gleam of light.
Begging for me to take a step closer.
"Just one more.
Now reach out, good girl.
Take me in your hand.
Tear a crack in the earth.
Make the water flow."
In the end, I give in.
Not like anyone will notice.
Not like anyone will care
So why not?
There is no reason not to
and every reason to.
My one and only friend
You kill me yet heal me.
You're opening scars
to close the wounds inflicted
upon my soul.
I love you yet
despise you.
My one and only friend.
My enemy.
The blade.
Truecat369 18-21, F 0 Jan 21, 2013


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Northeast University at Qinhuangdao Campus
Liu T.,Northeast University at Qinhuangdao Campus |
Liu S.,Northeast University at Qinhuangdao Campus
Inverse Problems in Science and Engineering | Year: 2017
This paper is concerned with the numerical identification of diffusion parameters in a non-linear convection–diffusion equation, which arises as the saturation equation in the fractional flow formulation of the two-phase porous media flow equations. In order to overcome the defect of the local convergence of traditional methods, an adaptive homotopy perturbation method is applied to solve this parameter identification inverse problem. The adaptive homotopy perturbation method provides a simple way to adapt computational refinement to the choice of the homotopy parameter. Numerical simulations illustrate that the proposed algorithm is globally convergent and computationallyefficient. © 2017 Informa UK Limited, trading as Taylor & Francis Group
He Z.,Harbin Institute of Technology |
Wang G.-X.,Harbin Institute of Technology |
Meng F.-W.,Northeast University at Qinhuangdao Campus
Dianji yu Kongzhi Xuebao/Electric Machines and Control | Year: 2015
A new design method for nonlinear H∞ control was proposed. Though sum of squares (SOS) method can be used to solve analytically unsolvable nonlinear problems, but it still cannot be used directly to solve the Hamilton-Jacobi-Issacs (HJI) inequality or the nonlinear bounded-real inequality. The restrictions of the SOS method were discussed in detail. An iterative design procedure for nonlinear H∞ control problems was presented. There are two steps in each round of iteration. The first step is to design the nonlinear state feedback with adjustable gain matrix by using the SOS method. The second step is to solve an optimal problem in computation of the L2-gain by using a graphical-analytical method. A nonlinear H∞ control design for large attitude maneuvers of statellites was presented as an application example of the proposed method. ©, 2014, Editorial Department of Electric Machines and Control. All right reserved.
Yuan H.,Northeast University at Qinhuangdao Campus |
Wang D.,Shenyang University
Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) | Year: 2010
The paper present a new approach of calculating the shortest paths, the approach was named as SPM (the shortest paths' matrix). Compared to the past approaches, SPM introduced distances into a matrix and could show activity distances directly in elements of the matrix and improved efficiency. The definition, operating rules of SPM and others related to SPM were described in this paper. At the end, the approach was applied to practical processes, the shortest paths were found out quickly. The approach provided a new resolution to the calculation of the shortest paths. © 2010 Springer-Verlag.
Huilin Y.,Northeast University at Qinhuangdao Campus |
Wang D.,Shenyang University
Proceedings - 2010 International Conference on Management of e-Commerce and e-Government, ICMeCG 2010 | Year: 2010
The new approach in this paper added role factor in the activity-section flow chart and proposed human-computer interactive, role-exchanged concept. It is used in a logistics system, remove the activity loops and reduce interactive times between sections or roles, so it is more suitable for electronic business process than before. © 2010 IEEE.
Zhang M.,China University of Mining and Technology |
Li G.,Northeast University at Qinhuangdao Campus |
Mu H.L.,Dalian University of Technology |
Ning Y.D.,Dalian University of Technology
Energy | Year: 2011
This paper aims at analyzing energy and exergy efficiencies in the Chinese transportation sector. Historical data is used to investigate the development of efficiencies from 1980 to 2009. Firstly, we calculate energy consumption values in PJ (petajoule) for nine transportation modes of five transportation sub-sectors. Then, the weighted energy and exergy efficiencies for each transportation mode, calculated by multiplying weighting factors with efficiency values of that mode, are summed up to calculate the weighted mean overall efficiencies for a particular year. We find that: (1) In 2009, the energy consumed in transportation sector was 12179.80 PJ, whereas that was 589.25 PJ in 1980. (2) Highways transport was the biggest energy consumer, which consumed 82.0% of total transport energy consumption in 2009. (3) Up to 2009, the oil consumed by transportation accounted for 75.1% of that in the whole country, which is more than the net oil import. (4) The average overall energy and exergy efficiencies are found to be 21.22% and 19.95%, respectively. (5) A comparison with other countries showed that energy and exergy efficiencies of the Chinese transportation sector are slightly lower than those of Jordan, Malaysian, Saudi Arabian and Norwegian, and higher than that incurred in Turkish. © 2010 Elsevier Ltd.
Zhai Y.-J.,Liverpool John Moores University |
Yu D.-W.,Northeast University at Qinhuangdao Campus |
Guo H.-Y.,Zhejiang University |
Yu D.L.,Liverpool John Moores University
Engineering Applications of Artificial Intelligence | Year: 2010
Current production engines use look-up table and proportional and integral (PI) feedback control to regulate air/fuel ratio (AFR), which is time-consuming for calibration and is not robust to engine parameter uncertainty and time varying dynamics. This paper investigates engine modelling with the diagonal recurrent neural network (DRNN) and such a model-based predictive control for AFR. The DRNN model is made adaptive on-line to deal with engine time varying dynamics, so that the robustness in control performance is greatly enhanced. The developed strategy is evaluated on a well-known engine benchmark, a simulated mean value engine model (MVEM). The simulation results are also compared with the PI control. © 2009 Elsevier Ltd. All rights reserved.
Yan T.,Yanshan University |
Yu E.,Yanshan University |
Zhao Y.,Northeast University at Qinhuangdao Campus
Materials and Design | Year: 2013
The hot deformation behavior of 55SiMnMo bainite steel was studied through isothermal hot compression tests conducted using a Gleeble 3500 at 950-1100°C, with strain rates of 0.01s-1 to 10s-1. A constitutive equation was established using the experimental results to describe the stress-strain relationship based on the dislocation density variation, considering the influence of the dynamic softening mechanism. When dynamic recovery is the only softening mechanism, a constitutive equation for flow stress was obtained from the variation of the dislocation density during hot deformation based on work hardening and dynamic recovery. When dynamic recrystallization occurs, the relationship between the dislocation density and the volume fraction of dynamic recrystallization was used to predict the flow stress after the peak. The reliability of the model was verified through a comparison between the predicted flow stress curves from the model and the experimental data. © 2013 Elsevier Ltd.
Liu H.,Yanshan University |
Liu F.,Yanshan University |
Hou D.,Northeast University at Qinhuangdao Campus |
Shi P.,Yanshan University
Jixie Gongcheng Xuebao/Journal of Mechanical Engineering | Year: 2012
Considering the role of nonlinear elastic constraint of the hydraulic pressure cylinder and compensating cylinder in the four-high rolling mill process, a multi-segmented nonlinear vibration dynamic equation of rolling mill rolls is established. Averaging method is used to get frequency response equation of the system, singularity theory is applied to analysis it and then 6 group transition sets and bifurcation diagrams are obtained, which show the various bifurcation forms of this system. The actual parameters of rolling mill is used to analyze the impact law that every nonlinear parameter on vibration characteristics of this system, after the numerical simulation the characteristics that the amplitude-frequency characteristic curves both show turning to the high frequency in each segment are found. Choosing proper system parameter can restrain this behave effectively, which provides a theoretical basis to suppress vibration of rolling mill rolls. © 2012 Journal of Mechanical Engineering.
Wang G.,Northeast University at Qinhuangdao Campus
Applied Mechanics and Materials | Year: 2014
New urbanization is an important feature of China's development. The development of urbanization has a far-reaching effect on the building materials industries. The development of the building materials industries is closely interrelated with all of the national economy, and it is obviously affected by macro economy and investment in the fixed assets. In the national economy, building materials industries is an important basic one, and plays an important role in the course of the industrialization and urbanization of our country. Urbanization needs to speed up the upgrade of the building materials industries transition, and come true the new Chinese-style industry. In the building materials industries, there are still many problems, such as Low-level competition, high pressure in eliminating the backward, and so on. The building materials industries provide an important material foundation to fixed assets investment of the urbanization. © (2014) Trans Tech Publications, Switzerland.
Liu T.,Northeast University at Qinhuangdao Campus
Computers and Mathematics with Applications | Year: 2016
By introducing the wavelet multiscale method and the homotopy method to the inversion process for the parameter identification problem of partial differential equations, a joint inversion method called the wavelet multiscale-homotopy method is proposed, which is globally convergent, computationally efficient, and has the anti-noise ability. As a practical problem, the parameter identification problem of the saturation equation in the fractional flow formulation of the two-phase porous media flow equations is solved. Numerical results validate the method's merits. © 2016 Elsevier Ltd.


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AUBURN HILLS, Michigan — The 2017 Ram 2500 Heavy Duty 4x4 Off-Road package, which debuts at the 2016 Chicago Auto Show, will be arriving at Ram dealerships in the third quarter of this year.
The package will be available in Crew Cab and Mega Cab versions, with gas and diesel powertrains, and in short- and long-wheelbase models, and can be ordered on all Ram 2500 trim levels.
A Ram spokesperson told Edmunds that pricing will be announced closer to the on-sale date.
According to Ram, up to 35 percent of pickup owners use their trucks in off-road environments for work and/or play, and the new Off-Road package is designed specifically to meet their needs.
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The truck rides on upgraded Firestone white-lettered all-terrain tires, in either LT 275/70R18E or LT 285/60R20E sizes, depending on model.
Available Hill-Descent Control allows drivers to modulate speed down steep, rugged grades using buttons on the column shifter, without the need for throttle or brake pedals.
Edmunds says: Ram is emphasizing heavy-duty offerings for 2017, something that should please shoppers who value extreme capabilities.