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HEADBAND 2.0 Hey guys - welcome back. Okay, it's not the new year yet, but I've been absent on the blog for a few days. Usually I miss blogging after two or three days, but this time I was just busy with visiting relatives and spending time with my family, that's why I didn't even think about taking pictures of what I wore and telling you weird stories about what I do ;-) Sorry for that, but we all need a break and rest and I had mine and now I am back and happy to blog again. Also, what else is there to do on a Saturday evening? =) So here are a few shots I took with one of my sisters today - I hope you all had an amazing christmas, lots of good food and nice talks with your families and friends.
So this is what I wore today - I went shopping with my sister - I was actually on a hunt for shoes but couldn't find any that I absolutely "needed". Instead I got myself another book. Recently I am really into reading, I told you, reading on the tube, on the way to the tube, on the way from the tube to the office, reading, reading, reading. I always liked to read books but never really had time to actually finish one as we had to read books for school in between and of course all the exams distracted me from reading a nice book. So while I don't study I thought about reading more than usual. Anyway, I wore this absolutely lovely camel coat from Sheinside today with a blue headband my mum made for me and this vintage handbag from my grandmum. I told you that I am challenging myself to wear more headbands - well, here's look number two! I love the bright blue color of the headband and this coat is absolutely amazing. If any of you are gossip girl fans, well this is one of the coats Blair is wearing in one of the shows. I ALWAYS wanted this coat as it has this really cool collar. First I wanted to sew exactly the same coat as soon as I saw her wearing it but then I found it on Sheinside and got crazy about it! Enjoy! xx
|boots - H&M
bag - vintage
coat - Sheinside
headband - selfmade by my mum
gloves - H&M


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Title: Nutribullet Recipe Book Smoothie Recipes For Weight Loss Detox Anti Aging So Much More Recipes For A Healthy Life Book 1 Subject: Nutribullet Recipe Book.
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subset: commoncrawl


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The financial crisis has reached extraordinary
proportions in recent months. At the same time commodity prices
increases have boosted headline inflation, depressing
consumption. Growth is expected to stagnate in the near term in
most advanced European economies as asset price booms deflate
and banks curb credit to reduce leverage. Growth will slow down
significantly in the emerging economies in Europe as well.
Mutually reinforcing deterioration in financial and economic
conditions is the main downside risk to the outlook. Stabilizing
financial conditions and nurturing growth are the key policy
priorities. In addition to the outlook, the report presents
analytical work on the impact of high commodity prices, the
turnaround in the credit and asset price cycles, and the
macroeconomic effects of cross-border labor flows.
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"I messaged him because I was curious about all the trips he was going on. (We both love to travel!)" Jacinta and Waylon have so many exciting things happening this year! Along with their engagement, they will be welcoming a new addition to their family this August! They decided that since all of their loved ones…Read More
All articles filed in Portrait Photography
Downtown Chattanooga, TN Engagement Photography Session.
"After only 1 day of communicating with Alex, I knew that I wanted to meet him in person." Bethany and Alex met and fell in love through online dating and a mutual love for craft beer. They decided to have their engagement pictures taken on the Walnut Street bridge because they wanted to honor the…Read More
Child Milestone Photography in Smyrna, TN
Emma and Matthew Milestones! I have had the pleasure of following this sweet family over the past year, capturing some pretty fun milestones! Here are some highlights of these precious littles!Read More
Wedding Proposal Photography on Lover's Leap at Rock City, Lookout Mountain.
"I could keep going but this woman has brought back the feeling of "the one" that I had lost hope for along time ago." Kunjan and Neha's love story started in Kunjan's parent's Indian grocery store. Neha saw Kunjan for the first time there, but Kunjan had seen her for the first time around campus…Read More
Fall Family Photography Session at The Bright Place in Mt. Juliet, TN.
Valladares Family Session As you will soon see, we had a little too much fun during this session! Playing in piles of leaves, honking the horn of an old truck, swinging in a tree swing, and so much more! Jacob, Julie, JJ, and Jarrod were so sweet and I am thankful to have had the…Read More
Fall Newborn Photography Session in Murfreesboro, TN.
Annabelle Newborn Sesson This little bundle of sweetness was a dream to photograph! Her sweet brother Johnathan and sister Lillian even proudly posed for a couple pictures with her! So happy for the Pancoe family and their new addition!Read More
Smyrna, TN Family Portrait Photography Session.
Jedele Family Session I had so much fun celebrating the addition of sweet Caleb into Brad, Christy, and Madison's family! Fall is of my favorite times of year for outdoor portraits because of the rich golden tones, especially right before sunset! I am so happy for this growing family!Read More
Chattanooga, TN Fall Mini Family Portrait Photography Sessions.
Chester Frost is so perfect for pictures year round, but this time of year is my favorite! Even though I typically prefer more environmental photography over classic posing, I had fun with my setup! The families were just precious and I was able to capture some great smiles.Read More
Smyrna, TN 1st Birthday Portrait Photography.
Mason is the sweetest, happiest little explorer! He is never short of a smile! I have been blessed by his family for many years and absolutely love watching them grow! I had the privilege of capturing his 6 month milestone along with the 1 year celebration today. We had such a great time playing around…Read More
Nashville, TN Newborn Photography Session.
Bentley Newborn Session I am so thankful that Mary and Levi welcomed me into their home for baby Bentley's session this past week! It took some time for us to find a rhythm, but once we did Bentley seemed pretty content! With a home full of love and Packers football, this baby boy is bound…Read More


text: Our King Valley home with its 'valley' topography, continentality, and cool climate has all the credentials for producing succulent, expressive Tempranillo. Spanish by origin, this is a versatile wine with a luscious palate and fine tannins making it eminently drinkable with any dining occasion. Aged in new and old French oak for 12 months, the wine is further aged in the bottle to enhance its drinking experience.


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Jersey Strong Home Inspection, LLC
10 Mccue Road
Morganville, NJ 07751
Morganville, NJ 07751
Jersey Strong Home Inspection, LLC
Welcome to Jersey Strong Home Inspection, here to assist you with all of your Home Inspection, Radon Testing and Wood Destroying Insection Inspection (termite inspection) needs. We service the counties of Middlesex and Monmouth, and thorough New Jersey. Give us a call today for a free estimate.
Learn how HomeAdvisor screens and approves their pros.
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Home Inspection
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Mold & Asbestos Services
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Areas of Expertise
- Home Inspection
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Business Hours(Please call to confirm)
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In Business Since: 2013
Memberships & Affiliations
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State Licensing
Trade: Radon Measurement Technician
License #: MET13307
Expiration: 10-28-2017
Trade: Pesticide Applicator
License #: 57094B
Expiration: 10-31-2017
Trade: Home Inspector
License #: 24GI00132400
Expiration: 04-30-2019
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HomeAdvisor allows Service Professionals to post information about themselves and their business on their profile. HomeAdvisor does not review or verify the information or representations set forth in those profiles, as they are self-reported by the Service Professional.
*HomeAdvisor verifies state-level licensing where applicable - note: some states require local or county level licensing and you should verify whether or not your pro is properly licensed.
Jersey Strong Home Inspection, LLC
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text:
Lot 0 Highway 337, Livingstone's Cove, Livingstone Cove, NS, B2G 2L1Listing ID# 201625028
Lot 0 Highway 337, Livingstone's Cove, Livingstone Cove, NS, B2G 2L1Listing ID# 201625028
$ 129,900
Lot 0 Highway 337, Livingstone's Cove
Livingstone Cove, NS B2G 2L1
- Listing ID 201625028
- Building Type: VACANT LAND
- Land Size: 10 acres+-
- Status: For Sale/Active
- Days on Market: 334
Travel time
Property Description
OCEAN VIEW: Great opportunity to build home on this beautiful property with a panoramic ocean view. This property overlooks Livingstone Cove wharf and minutes from walk on beach. Enjoy the warm days of summer as you roam this property which includes a wonderful brook, Christmas trees and in the heat of the summer the wharf is minutes away for fishing, diving or just dreaming. Seller says the water is good and his own well never goes dry and that the land is rich farm land. Property is a 20 min drive to down on the new portion of Hwy 337. This property is listed under Parent PID and will be allocated a new PID upon subdivision and closing. Vendor will pay for subdividing and grant access to road way.


text:
Just Beginning!
I have put weight on over the past year, slowly creeping up to 11 stone. I have always been slim, size 10 and able to eat what I wanted. Never really appreciated how lucky I was until now! I have been made redundant so not rushing around as much as I used to. I guess I have been over eating out of boredom or stress or both!! I am finding it really hard to cut down on my food and feel a bit like a rabbit in the headlights...not knowing what to do. My son has told me to just do more exercise, I don't think that's enough? Feel very sluggish, and not being able to wear what I want is a little frustrating. Would appreciate some words of encouragement and wisdom at this early stage....thank you
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This is a 12 week league on Tuesdays at 7:30 pm starting October 28th!!
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After clicking on calendar and date below,decide how many people to sign up, put a check in the box for the time slot, then proceed. You will receive an email confirmation.
(Visa and Mastercard is our accepted form of payment. Sorry, we do not accept American Express)
[Las Vegas League]


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Lion Dance Festival Slot
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Lion Dance Festival Slot
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Win Scatter 1 on reels 1 – 3 to activate the Dancing Lion Free Spins bonus. Before the start of the bonus round, pick between three different scenarios, based on variance and risk. Choose between 5 free spins at a x10 multiplier, 10 free games at a x5 multiplier, and 15 freebies at a x3 magnifier. Whichever feature you choose, it can be re-activated with the same three Dragon Scatters.
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Arginine vasotocin (AVT) is a nonmammalian analog of the mammalian hormone arginine vasopressin (AVP). These peptides are known for their antidiuretic and pressor effects. More recently, AVP has been recognized as an important antipyretic molecule in mammals. However, no information exists about the role of AVT in febrile ectotherms. We tested the hypothesis that AVT is an antipyretic molecule in the toadBufo paracnemis. Toads equipped with a temperature probe were placed in a thermal gradient, and preferred body temperature was recorded continuously. A behavioral fever was observed after lipopolysaccharide (LPS) was injected systemically (200 μg/kg). Systemically injected AVT (300 pmol/kg) alone caused no significant change in body temperature, but abolished LPS-induced fever. Moreover, a smaller dose of AVT (10 pmol/kg), which did not affect LPS-induced fever when injected peripherally, abolished fever when injected intracerebroventricularly. We therefore conclude that AVT plays an antipyretic role in the central nervous system, by means of behavior, in an ectotherm, a fact consistent with the notion that AVT/AVP elicits antipyresis by reducing the thermoregulatory set point.
- behavioral fever
- antipyresis
- body temperature
- lipopolysaccharide
- Bufo
fever is a regulated increase in body temperature (Tb) often described as a rise in the thermoregulatory set point (16). With few exceptions, both endothermic and ectothermic vertebrates (as well as invertebrates) develop fever in response to injections of exogenous pyrogens such as lipopolysaccharide (LPS; endotoxin), viruses, gram-positive bacteria, and yeast. LPS, which is the most purified form of a compound from the cell wall of gram-negative bacteria, usuallyEscherichia coli, has been extensively used to induce fever in experimental animals (for a review see Ref. 16). To our knowledge, no information exists about the effect of LPS injection in toads.
Considerable efforts have been made to identify the mechanisms of fever, and evidence suggests that exogenous pyrogens stimulate the immune cells to produce and release cytokines, such as interleukin (IL)-1β, IL-6, interferons, and tumor necrosis factor (16). Classically, cytokines are known to stimulate the generation of prostaglandins in the central nervous system, particularly PGE2, thought to act as one of the final mediators of fever (26). In addition to this conventional viewpoint, recent evidence has accumulated that distinct mechanisms may be evoked depending on the route of pyrogen administration (10) and the sort of pyrogen injected (16, 42)
In addition to the action of pyrogens increasing Tb, endogenously formed antipyretic factors also participate in the febrile response. These substances have been proposed to play an important role in preventing excessive rises in Tb (16).
The mammalian peptide arginine vasopressin (AVP) has been recognized as an important antipyretic molecule in mammals (16, 30, 39, 40). As to nonmammalian vertebrates, arginine vasotocin (AVT) is the antidiuretic and pressor substance present in the neurohypophysis (37). AVT is a nonapeptide considered to be the most primitive known vertebrate neurohypophysial peptide of the vasopressin/oxytocin hormone family and may thus be ancestral to all the other vertebrate peptide hormones (see Ref. 21). However, no information exists about the role of AVT in febrile ectotherms, which are an interesting model to study thermoregulation because they rely essentially on behavioral mechanisms for Tb control, which is usually related to changes in the thermoregulatory set point (4, 5, 38).
In view of these considerations, we tested the hypothesis that AVT is an antipyretic molecule in the toad Bufo paracnemis. We therefore measured the preferred Tb of Bufo paracnemis after injections of LPS, AVT, or a combination of both.
Animals. Toads (Bufo paracnemis Lutz) of either sex weighing 150–250 g were collected on the Campus of the University of São Paulo, Ribeirão Preto, São Paulo state, Brazil. On arrival at the laboratory, the animals were kept indoors in aquariums with free access to tap water and basking areas at ambient temperature. All animals were fed meal worms once a week until 1 wk before surgery. Each animal was used only once, and all the experiments were performed between 2:00 PM and 6:00 AM.
Surgery. The toads were anesthetized in an aqueous solution of 3-aminobenzoic acid ethyl ester (MS-222; 0.3%; Sigma). For the temperature selection measurements, a thermistor probe was secured into the cloaca with skin sutures the day before the experiments began. All animals recovered promptly from anesthesia. After suture, the animals were left undisturbed for at least 24 h at 22–25°C in containers with free access to tap water and basking areas.
Toads used for intracerebroventricular injection had the fourth cerebral ventricle cannulated as previously described (3). Briefly, during anesthesia (induced by submergence in 0.3% MS-222) the skin covering the caudal half of the skull was removed and an orifice was formed by cutting out a circular piece of connective tissue between the first vertebra and the occipital bone. This orifice provided access to the fourth ventricle. A catheter (0.7 mm OD) was stereotaxically placed inside the orifice with the tip protruding into the cerebrospinal fluid (CSF) of the fourth ventricle. The opening was sealed with bone wax followed by an application of dental acrylic (Dental Fillings do Brasil), which secured the assembly in place. Screws had been drilled in the occipital bone and first vertebra to provide a firm contact after fusion with the acrylic. A tight-fitting mandril was kept inside the guide cannula to avoid its occlusion. This preparation allowed intracerebroventricular injections. All animals recovered from surgery within 1–2 h.
Another group of toads was anesthetized (submergence in 0.3% MS-222), and an arterial catheter (PE-50) filled with heparinized Ringer solution was occlusively inserted into the femoral artery. All animals recovered promptly from anesthesia.
Measurement of preferred Tb. Preferred temperature was determined in a thermal gradient chamber (1.5-m long, 0.15-m high, and 0.2-m wide) with an aluminum floor. One end of the floor was cooled to 10°C by a copper pad connected to a refrigerated water bath (VWR Scientific, 1160A, Niles, IL). An electrical resistor heated the other end to 40°C. Petri dishes filled with tap water throughout the chamber provided access to water at all temperatures. An animal with a cloacal temperature probe was placed in the center of the temperature gradient, and the thermistor output was continuously displayed on a chart recorder using a NARCO polygraph (Narcotrace 80).
Measurement of arterial blood pressure and heart rate. Arterial blood pressure was measured 24 h after surgery by connecting the arterial catheter to a Narco pressure transducer (Austin, TX, model P-1000B). The signal from the transducer was recorded on paper (Narcotrace 80). Heart rate was determined by counting pressure pulses.
Experimental procedure. Experiments were performed on conscious, unrestrained and undisturbed toads. One toad was placed in the middle of the temperature gradient and left there for 16 h. At the 5th h (time zero), Ringer, LPS (from Escherichia coli, serotype 0111:B4, Sigma), AVT (Peninsula), or a combination of all were injected into the dorsal lymph sac of the animals. The doses used were 2, 20, or 200 μg LPS/kg body wt and 10 or 300 pmol AVT/kg body wt in a final volume of 0.4 ml. The doses of LPS were based on pilot experiments and on the fact that they represent a common range of LPS doses used in other endotherm experimental models (10, 22, 33, 36), whereas the doses of AVT were based on a previous study on toads (23). The gradient chamber was continuously flushed with humidified room air at a rate of 1.5 l/min.
In another set of experiments, toads with the fourth cerebral ventricle cannulated were kept in the thermal gradient and injected at the 5th h (time zero) with LPS into the lymph sac (200 μg/kg) followed by an intracerebroventricular injection of mock CSF or AVT (10 pmol/kg). Other animals received injections of mock CSF or AVT (10 pmol/kg) only. A 10-μl Hamilton syringe and a dental injection needle (Missy, 200 μm OD) were used for all the intracerebroventricular injections. Injection was performed over a period of 2 min, and 1 min was allowed to elapse before the injection needle was removed from the guide cannula to avoid reflux. Preferred Tb was then continuously monitored for 11 h. The ionic composition of the mock CSF solution was (in meq/l) 56.6 NaCl, 2.7 KCl, 0.9 CaCl2, 0.45 MgSO4, and 27.0 NaHCO3.
Experiments in which blood pressure was measured were performed on animals maintained at 23–25°C in a chamber that was continuously flushed with humidified room air at a rate of 1.5 l/min. Arterial blood pressure was recorded for ∼5 min before and 1 and 2 h after the injections of Ringer or LPS (2, 20, and 200 μg/kg) into the lymph sac.
Calculations and statistical analysis. Mean preferred Tb was determined every hour in all experiments from individual chart paper recordings by manual calculation on the basis of a previous calibration. Repeated measures ANOVA was used to compare Tbs at each hour after injection with the value at time zero (the value immediately before the injections), and the difference between means was assessed by the Tukey's test. Mean arterial blood pressure was estimated from the pressure pulse with the use of the following formula: mean blood pressure = diastolic pressure + (systolic pressure − diastolic pressure) (20). Ordinary ANOVA was used to compare mean blood pressure and heart rate among the different groups, and the difference between means was assessed by the Tukey's test. All values are reported as means ± SD. Values ofP < 0.05 were considered to be significant.
During the control period, mean Tb was 23 ± 1°C (a mean of the previous 5 h before injection for all protocols). Ringer injection caused a transient nonsignificant tendency to a reduction in Tb (Fig.1).
Effect of LPS on preferred Tb of toads. Figure 1 shows the temporal effect of LPS injection on Tb. LPS at the dose of 200 μg/kg, but not at smaller doses, caused a significant increase in Tb from the 8th to 11th h after injection (P < 0.05). Thus the dose of 200 μg/kg of LPS was chosen for further experiments. A transient nonsignificant reduction in Tb was observed after all injections of LPS (Fig. 1).
Effect of LPS on arterial blood pressure and heart rate of toads.Table 1 shows the effect of systemic LPS on arterial blood pressure and heart rate before and 1 and 2 h after injection. No dose of LPS caused a significant change in blood pressure or heart rate.
Effect of AVT on LPS-induced fever in toads. Figure2 illustrates the effects of systemic AVT on preferred Tb and on LPS-induced behavioral fever. AVT injection only (10 or 300 pmol/kg) caused no change in preferred Tb of the toads, whereas AVT at the dose of 300 pmol/kg abolished the rise in Tb caused by systemic administration of LPS (200 μg/kg).
Additionally, a small transient reduction in Tb was observed after intracerebroventricular injection of AVT (10 pmol/kg) or mock CSF (Fig.3). However, intracerebroventricular injection of AVT (10 pmol/kg) abolished LPS-induced fever (Fig. 3).
The present study provides evidence that LPS induces behavioral fever in the toad Bufo paracnemis, a response that is abolished by intracerebroventricular injection of AVT at a dose that does not alter fever when injected peripherally. To our knowledge, this is the first study that reported an antipyretic role of AVT by means of behavior, a fact consistent with the notion that AVT/AVP elicits antipyresis by reducing the thermoregulatory set point.
As reviewed by Kluger (16), fever results from a rise in the thermoregulatory set point. In mammals, which use autonomic and behavioral mechanisms to maintain Tb, fever is functionally expressed as increases in metabolic heat production and decreases in heat loss, in addition to behavior (6). However, thermoregulation in ectotherms is primarily behavioral and thus preferred Tb in ectotherms has been shown to be directly related to changes in the thermoregulatory set point (4, 5, 38). This characteristic certainly makes ectotherm species an interesting model for the study of thermoregulation.
In our experiments, LPS (200 μg/kg) caused a significant increase in preferred Tb (Fig. 1). This implies that toads, similar to several other species, respond to LPS by increasing Tb. However, toads seem to be less sensitive to LPS than mammals (10, 33, 36) and birds (22), because in the present study relatively higher doses were needed to cause fever in Bufo. Moreover, in our experiments, the onset of fever in toads occurred 8 h after LPS injection, a longer period than usually observed. First of all, it is important to point out that this longer latency for fever installation is not due to the inability of toads to select preferred Tb quickly when in a thermal gradient, because several studies (4, 5, 24) have observed consistent changes in preferred Tb of toads 1 h after application of the stimulus. Actually, a number of studies have observed different onset latency times for LPS fever, ranging from 15 min (19) to 2.5 h (36), depending on the species, dose, and route of administration. Usually, the higher the LPS dose the shorter the latency of fever onset after intraperitoneal LPS (19), but that may not be true when the LPS dose is further increased (33, 36). However, the LPS dose seems to be of minor importance in determining the latency of the fever onset in toads, because in the present study this pattern was not dose dependent (Fig.1). Furthermore, intraperitoneally injected LPS is usually associated with longer fever latency compared with intravenously injected LPS (19,36). Thus we may suggest that the long latency of LPS fever observed here in toads was probably due to a slow distribution of the drug through the lymphatic system. Finally, a low pyrogenicity of LPS in toads may account for the long latency of fever installation, whereas other pyrogens may elicit a more rapid response. Certainly, further research is needed to determine the reason for the long latency of LPS fever in toads.
The advantage of fever lies in an inherent improvement in immune system function and a reduction in pathogen (especially bacterial) growth at febrile temperatures (see Refs. 16, 22), with consequent increment in survival (17, 33, 38). Fever in ectotherms was first observed in lizards (17, 38) and has since been reported in amphibians (27), fishes, and even some invertebrates (see Ref. 18), indicating that fever has an ancient phylogenetic history. However, a few exceptions exist: rabbit leucocyte pyrogen and pyrogenic suspension of killedAeromonas hydrophila bacteria fail to produce fever in the lizard Cordylus cataphractus (18); E. coli-endotoxin and PGE1 also do not induce fever in the teleost fishLepomis gibbosus (25).
The present study also demonstrates that LPS-induced fever in toads was preceded by a nonsignificant reduction in preferred Tb, which seemed to be due, at least in part, to manipulation of the animals (4, 5). It should be pointed out that a transitory hypothermia was observed after most intracerebroventricular injections when the animals were manipulated for a longer period of time (total of 3 min) compared with the systemic injections. The observed tendency to a reduction in Tb could be due to an endotoxin shock reaction (31). However, this possibility seems unlikely because LPS injection caused no significant change in arterial blood pressure (Table 1). Furthermore, combined administration of AVT (300 pmol/kg) and LPS significantly reduced Tb, although injection of each agent alone did not (Fig. 2). The reason for this phenomenon is unclear. As far as we are concerned, there is no evidence in the literature indicating an interaction between AVT and LPS in decreasing Tb. Further studies are needed to establish the mechanisms involved in the transitory reductions in Tb observed in the present study.
As to the effect of systemic AVT on Tb, previous studies have observed that AVT may decrease Tb of euthermic pigeons (12, 13), but our data indicate that the same does not occur in toads (Fig. 2). As to febrile toads, we observed that AVT abolished LPS-induced behavioral fever (Fig. 2). Altogether, these results indeed support AVT as an antipyretic molecule in the toad Bufo paracnemis, because an antipyretic is defined as a substance that can reduce the Tb of febrile animals but has no effect on normal (nonfebrile) Tb unless the dosage is excessive (1). In support of the antipyretic effect of endogenous AVT is the fact that plasma AVT levels rise during fever in Pekin ducks (11).
AVT may exert its antipyretic action by increasing arterial blood pressure in toads (23). In rats, AVP per se has been reported to cause hypothermia when administered intravenously (34, 35), a fact that has been attributed to the baroreflex suppression of thermogenesis (34). However, in the case of toads, we think this is unlikely because the effect of AVT on blood pressure is immediate (unpublished data) and persists for a short period of time (minutes; Ref. 23), whereas its antipyretic effect persists for hours (present study). More studies are needed to clarify this issue.
It is interesting to note that during dehydration plasma AVT concentration increases from 1.5 × 10− 11 M (hydrated animal) to 4.9 × 10− 11 M in Bufo marinus (8) and from ∼5 × 10− 12 M to 5 × 10− 11 M in Rana catesbeiana (32). It would be possible to speculate that AVT is involved in the decrease of Tb when toads are exposed to dry air without access to water (24). However, this seems unlikely, because in the present study, for the 300 pmol/kg dose, a concentration of 1.5 × 10− 9 M can be estimated by assuming that AVT injected into the lymph sac is evenly distributed throughout the extracellular space and that extracellular water is 20% of total body mass (2). Thus the AVT levels of our toads after bolus injection may be ∼30-fold more concentrated than the value reported for dehydratedBufo marinus (8), and we did not observe a reduction in Tb in this condition. Nevertheless, we report an antipyretic effect of AVT. Further studies are needed to assess this effect under physiological conditions such as dehydration. Unfortunately, to our knowledge no information exists about AVT concentration in the CSF of toads, so we are unable to draw conclusions about this matter.
Although our data indicate that systemically administered AVT plays an antipyretic role in toads, we did not establish the exact site where peripherally injected AVT acts to evoke antipyresis. This site is likely to be centrally mediated. Although AVT may not cross the blood-brain barrier [in mammals AVP does not (29)], this systemically administered peptide may interact with the central nervous system (CNS) through receptors present in the vessels of the circumventricular organs of the brain, which are known to lack a blood-brain barrier (9).
In our experiments, AVT injected intracerebroventricularly at a dose (10 pmol/kg) that did not affect fever when injected peripherally, completely abolished LPS-induced fever in toads, indicating that AVT elicits antipyresis in toads by acting on the CNS. Taken together, our results indicate that central AVT acts as an antipyretic peptide in toads, a fact that may or may not account for the antipyretic effect of systemically administered AVT.
Accordingly, AVP seems to exert its antipyretic action by acting on the ventral septal area (VSA) of the CNS of mammals (for a review see Ref.30). It has been observed since 1974 that near the end of pregnancy, ewes were unable to develop fever (see Ref. 17). Among all the hormonal pattern alterations that occur during pregnancy, Naylor et al. (28) found that AVP concentrations were consistently correlated with the suppression of fever. In agreement with this evidence, further studies gave support to the antipyretic effect of AVP: 1) AVP infusion into the VSA of the CNS attenuates or prevents febrile increases in Tb in sheep, rabbits, and rats (for a review see Refs. 16,30), whereas in the same experiments AVP infusion into the VSA at the same dose caused no change in Tb of euthermic rats; 2) VSA is a site of AVP-containing nerve terminals and high concentrations of AVP receptors in the CNS (7); 3) AVP levels increase in plasma and CSF during fever (15); 4) hypertonic saline and hemorrhage, which are potent stimuli of AVP release, cause antipyresis in rats (14); 5) administration of specific AVP antagonists into the VSA results in greatly enhanced fever (41).
Because AVT abolished behavioral fever of the toads, whose changes in preferred Tb are related to changes in the thermoregulatory set point, our data indicate that AVT reduces the thermoregulatory set point during fever. Some studies have been conducted to determine the mechanism by which AVP attenuates fever in mammals. Wilkinson and Kasting (39) reported that AVP injected intracerebroventricularly decreases the brain temperature of febrile rats more than that of nonfebrile rats at an ambient temperature of 4, 25, and 32°C, suggesting that AVP affects the thermoregulatory set point rather than a specific thermoregulatory mechanism. Indeed, it has been reported that when AVP is injected intracerebroventricularly, the thermoregulatory strategy to reduce fever varies at different ambient temperatures and is not due to changes in a single effector mechanism (40). Altogether, these data implicate the AVP/AVT system in eliciting antipyresis by decreasing the thermoregulatory set point.
In summary, our data indicate that AVT plays an important role in the behavioral thermoregulation of the toad Bufo paracnemis, acting on the CNS as an antipyretic peptide during LPS-induced fever.
During evolution, animals have developed some antipyretic mechanisms to counteract excessive rises in Tb. A series of studies using different animal models has been conducted to describe the mechanisms of fever to provide a better understanding of the pharmacological modulation of fever as well as the basis for the development of new antipyretic drugs. Ectotherm species have emerged as an interesting model to study the mechanisms of fever, because they rely essentially on behavioral mechanisms for temperature regulation, which has been shown to be related to changes in the thermoregulatory set point. The data obtained from a wide diversity of studies as well as the study of the phylogenetic history of pyrogens and cryogens will certainly lead us to a more complete understanding of the mechanisms underlying fever.
This work was supported by Fundação de Amparoà Pesquisa do Estado de São Paulo (FAPESP), Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico, and Programa de Apoio a Núcleos de Excelência-Ministero de Ciências e Tecnologia. K. C. Bicego-Nahas and A. A. Steiner were supported by FAPESP.
Address for reprint requests and other correspondence: L. G. S. Branco, Departamento de Morfologia, Estomatologia e Fisiologia, Faculdade de Odontologia de Ribeirão Preto/USP, 14040–904 Ribeirão Preto, SP, Brasil (E-mail: branco{at}forp.usp.br).
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
- Copyright © 2000 the American Physiological Society


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Catwoman: Defiant
Format: original graphic novel
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Date: 1992
Writer(s): Peter Milligan
Storyline: Batman saved Catwoman from Mr. Handsome's thugs and asked her for a favor. She wore a tracking device and agreed to be captured by the "Model Army" so Batman could take them down. While tailing her, Batman fell for a diversion and she was taken. When she awakened, she was in a dungeon being watched by Mr. Handsome. When an ogre-beast attacked, she was helped by Mr. Handsome's discarded wife, Mary. She and Mary attempted to escape, but Mary couldn't make it. She made Selina promise to kill her husband. Batman got their location by torturing one of Handsome's goons; he was on his way. Catwoman made it to Handsome's room and went for him. She took off his mask to find Mary, who'd killed him years before and assumed his role. The ogre escaped and was in the room with them. Catwoman escaped and it killed Mary. Batman showed up while Catwoman left with some artwork.


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I am sure this has been asked before but a search did not turn up exactly what I am looking for.
I just reviewed the latest finding by GUYS of LIDAR and am unclear on the effectiveness of lazer jamming technology. But then I see references to Black cars being more invisible and better candidates for jamming technology. Are there any suggestions on the best product to purchase to protect this type of vehicle?
Thanks in advance for your responses!


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Originally posted April 1, 2014
Every time I think, "What's the use?" I am reminded of this little saying. Tomorrow will come anyway even if I get nothing done today. Next week, next year, and next month will all come anyway if we are still on this earth. That leaves the question of what I will do with that time. I can do nothing and nothing will be different in those areas I can control. I would be right where I am now. Stagnant. The opposite can happen. I can do something or maybe many somethings that could enrich my life. It is time for me and you to pull up our boot straps and get busy. (Here's a reference if you are unfamiliar with that phrase. http://www.phrases.org.uk/meanings/290800.html)
What will you do daily to improve your life by this time next year? What will I do?
One of my joys is writing, as you know. I have several stories started. I have recently began two new writings. My intent is to have three stories finished by this time next year. They may never be read by anyone but me and maybe those closest to me, but that's ok. I write for the pleasure of writing. Don't get me wrong here. I desire that they be read by the world, but my world won't dissolve if they aren't published.
The last few years my biggest accomplishment was survival. Last year this time, I couldn't put words together. This year, words flow freely.
Stay tuned to find out if I make it.
Live improving your life daily.


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Foreign Exchange & Currency Transfer
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Kanoo Bureau de Change
Currency exchange company located at 11, cours de l'Intendance 33000 Bordeaux. Open Monday to Friday 09:30-18:00. June to September Monday to Friday 09:30-13:30.
Allez Francais
Offer assistance with raising insurance and currency transfers. Ask for Peter.
ICE France Bordeaux City City
International Currency Exchange located at 40 Rue du Docteur Charles Nancel Penard 33000 Bordeaux. Open Tuesday to Saturday 09:00-17:00.
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Pioneer France
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Travelex Bureaux de Change
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Service Area of Availability
Available between 10AM-7PM Monday - Saturday
Areas free of travel charge include:
in the comfort of YOUR own home in
Bradenton, FL
Bird Key, FL
Longboat Key, FL
Lido Key,FL
Sarasota, FL
Siesta Key, FL
Some of the many benefits of mobile massage include:
No rush to make appointment times.
No contracts.
No memberships.
No need to hire child care.
No stress.


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HOUSTON, TX (WTVD) --NASA just released two stunning videos this week captured by the International Space Station 4K camera.
Hues of blue and green dance along the surface of the earth. The high definition video was captured on board the International Space station. A series of time lapse shots showcase the beauty of the Aurora Borealis and the Aurora Australis. The Aurora Borealis is only visible in the northern most latitudes, which explains the nickname, "northern lights."
The Aurora Australis is visible in the southernmost latitudes, like Antarctica, Chile and Australia.
Both auroras occur when electrically charged electrons and protons in the Earths atmosphere collide with neutral atoms from the upper atmosphere, and the result is breathtaking.
The same 4K camera captured these crystal clear images of Earth. You can see clouds, desert ground, and large bodies of water vividly.
Be amazed! View Ultra High Definition (4K) Earth observations from the @Space_Station crew: https://t.co/hFvgoQT0Cphttps://t.co/LkeOeGAaRq— NASA (@NASA) April 18, 2016
Although the ISS takes stunning pictures, crew members spend most of their time monitoring the earth's vital signs. The ISS travels at a speed of five miles a second, orbiting the Earth about every 90 minutes.
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First off it is very dark in there. My wife and I needed our iPhones to read the menu. A shrimp cocktail was $20!! The cocktails were very good and the service was grade A first class. It was the best part of the meal....More
11 - 20 of 327 reviews
First off it is very dark in there. My wife and I needed our iPhones to read the menu. A shrimp cocktail was $20!! The cocktails were very good and the service was grade A first class. It was the best part of the meal....More
We stopped in for impromptu cocktails, not knowing what to expect. Shad, the owner (and excellent bar man), was very friendly and attentive. We were both pleased with our cocktails and enjoyed the light-hearted Trivial Pursuit "game" while we waited for our Hor d'Oveuvres. Our...More
If you are looking for a small, private, dinner with superior service go to The Library. The service was top of the line. The servers were respectful, responsive, helpful, and friendly. The food was delectable. My husband and I took our two boys; 11 and...More
When we visit Myrtle Beach, before we head home, this is our last dinner stop. Why you ask? Well, it is soooo good that if we ate there the first night of our stay, we would want to eat there every night and we would...More
My husband I visited this restaurant after reviewing TripAdvisors recommendations. The food was ok to good and the waiter was good. The ambience was totally lacking. We were seated at a table that was under some bright light and I asked for the lights to...More
Its our first time in Myrtle beach and dined here on our first night. The food was delicious and the service was what took to the top!! The lamb is out of this world and the Salmon was pretty good. If you go there ask...More
Wonderful food, service, alcohol selection, ambiance, and atmosphere. The table side prepared foods are unique and fun. You won't regret going to this restaurant.
Annual stop in Myrtle Beach. Caesar salad made tableside, Steak Diane-tableside, Chicken Chardonnay, Grouper with a lobster sauce and fresh hot rolls made to order. Incredible flavor and service. Great for special occasion, business, family or a romantic dinner.
Excellent service. Best duck. We will become a regular. Every thing very fresh. Very good wine selection.
I have lived here for several years and this was my first visit to the Library. What an amazing experience. The restaurant itself is a welcoming and relaxing old time building with all the comforts. Don't judge by the outside. The service was an amazing...More


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This morning when President Obama addressed the nation because of the mass shooting in Orlando, I daydreamed that in the middle of his speech he would stop and say:
"You know what: F*%# THIS. I am tired of giving these speeches. I am sick to death of pretending this is a "tragedy" when we all know we could do any number of things to make guns harder to get. Come on. How many times do I have to console family members whose loved ones were innocent bystanders and whose killer legally got a semi-automatic weapon that indiscriminately slaughtered their child/partner/friend/loved one? WTF."
But he didn't. Obama was presidential. Which is his job I guess. Addressing a nation who woke up on a Sunday morning to hear that fifty people were gunned down in a club because someone wanted to cause terror. He told us it was a tragedy. He said the FBI is working on it. He told us that this was a terrorist act and the pundits then spent a bunch of time talking about what those words mean. Terrorism vs. Hate crime.
What he said seemed like déjà vu.
Why? Because we all know how this story goes.
Obama will end up comforting the victims and families of those who were slain talking to them about their child/father/mother/friend/partner. Maybe there will be a photo op including a fist bump with someone who is recovering the surgery that removed bullets from their thigh/back/arm/chest.
Later he will try to get people interested in creating new legislation. They won't be interested enough to stand up to the NRA.
We all know how this story goes.
In the days to come, we will hear stories of people whose lives were cut short by senseless violence/were in the wrong place at the wrong time/were going out for an evening with friends. We will hear that they were just about to get married/send their children to college/go on a trip around the world. We will learn about their quirks: they made everyone around them laugh/loved eating Indian food/couldn't wait to watch the next season of The Great British Bake Off/were a horrible singer but loved karaoke anyway.
And then we will investigate our own life and shake our head and say that it's a shame/we wish we could do something/we wish this hadn't happened/someone should really do something about that.
We all know how this story goes.
Later in the day, I listened to the radio. A woman was interviewing someone who had been inside the club and escaped out without injury. The interviewer asked "Did you hear anything said out loud?". The guy hadn't heard anything said out loud. We all know why she asked this question. We know that sometimes in a mass shooting, a shooter/bystander/victim will say something memorable. We know that those last words are horrific but fascinating. We can talk about those words later when we talk to friends about how awful this was.
We all know how this story goes.
I check into Facebook and people have posted broken hearts/candles/rainbow flags. My friends who were so celebratory just yesterday attending Pride are now posting somber comments.
Some post that Onion article that says "'No Way to Prevent This' Says Only Nation Where This Regularly Happens"
Some write angry posts that blame semi-automatic weapons/violence in the media/Trump/the NRA.
Some write that they will hug their loved ones closer.
Some change their profile pictures to reflect a meme.
We all know how this story goes.
My friends, we are far too knowledgeable about how to react to a mass shooting.
We all know how this story goes.
This time, I can't bring myself to change my profile picture/post that Fred Rogers quote where he talks about the helpers/pretend that I'm not utterly wrecked by the fact that my country keeps making weapons available so that more innocent people are shot.
Let's change this story. Let's rewrite it. Let's do something different this time. Please?
Let's write emails/letters/make calls to Congress/The President/Local Newspapers/Neighbors/Friends saying something simple like:
"Hey guys, we have got to do everything we can to not have another San Bernardino/Sandy Hook/Charleston/Navy Yard/Aurora/Virginia Tech/Columbine"
"Let's create legislation that will create background checks/mental health checks/a federal database to track guns/semi-automatic weapon bans/a ban on assault weapons/a ban on online sales/a ban on high capacity clips/closing loopholes/increase funding for mental health"
"Let's talk honestly about what might prevent these massacres and change this narrative. As a community/family/school/town/country we have to work together."
Something else that I haven't thought of? Just SOMETHING? Because I'd like to stop knowing how this story goes.
I want a new story.


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Do veterinarians need videos on their websites?
Don't be left behind; harness the power of multimedia.
Jun 19, 2013
Video content is everywhere on the Internet, and Dr. Laurie Hess says it's time for your website to get on board with videos that serve important educational—and promotional—purposes.
Hot topics on dvm360
Confessions: Pet pain, death and dying
Jun 27, 2017


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The admissions process for the doctoral degree consists of multiple levels of review and is a highly competitive process. The admissions process begins with online application and submission of all required materials to the KSU Graduate College. When all materials have been received by the Graduate College, the applicant file will be forwarded to the WellStar School of Nursing for review.
The final evaluation of applicant files is conducted by the WellStar School of Nursing's Doctoral Admissions Committee. That committee, composed of doctoral program faculty representatives, employs rubrics to systematically evaluate the merits of each applicant's admission file. The Committee's recommendation for admission into the DNS program is based upon the Committee's collective professional judgment of the overall merits of the applicant's case in the context of the quality of the applicant pool and the availability of openings for doctoral student supervision with the faculty in the program's areas of concentration. Consequently, the more qualified applicants there are for a limited number of new student openings, the more competitive the selection process becomes.
A critical aspect of the final level of review is the applicant's interview with program faculty. Interviews are structured with a predetermined set of questions to which applicants respond.
The determination of the merits of each applicant's case focus on a number of key variables that are vitally important to a candidate's ability to successfully complete the program at the highest level of scholarly study which includes a major applied research contribution to the profession of nursing related to leadership in nursing education or responses to health disparities. Those factors include: related undergraduate and graduate degrees (master's required); academic performance and achievement; professional practice and employment history; verbal and writing skills; quantitative and problem solving skills; evidence of professional effectiveness and ethics; evidence of professional leadership; compatibility with program mission and goals; and other related contributions and achievements of note.
Admission Requirements
- Official transcripts of all previous college work, graduate and undergraduate.
- Master's degree with a major in nursing from a nationally accredited program.
- Official GRE scores of 153 Verbal, 144 Quantitative, and 3.5 (minimum) analytic writing (or the equivalent on the newly normed version). GRE scores will be considered from applicants whose scores are more than 5 years old (GRE reporting limit), but who can produce "official documentation" of their scores.
- A current license to practice professional nursing in the United States. (Nursing credentials of international students will be assessed individually).
- A course in statistics.
- A course in research at the graduate level.
- Three letters of recommendation from individuals who can address the applicant's abilities to do doctoral level work (hold a doctoral degree or equivalent).
- A curriculum vitae or resume.
- A written statement of personal and professional interests and goals related to nursing doctoral study (1-2 pages in length). Be sure your name is on your statement.
- Personal interview with program faculty.
Transfer Credit
If accepted into the program, up to 15 post-master's graduate semester hours of comparable transfer credit for the DNS may be accepted toward completion of the requirements. Transfer credit will not be accepted for the core course requirements that are central to the program's distinctive focus. Consequently, transfer credit considerations are typically restricted to elective courses and possibly statistics courses. Decisions about the acceptability of transfer credit will be made on a case-by-case basis and must be approved by the Doctoral Advisor and Director of the Doctoral Program.
Applications must be received by March 1 for Fall Admission.Apply Here
If you have any questions after looking over the information presented above, please contact the DNS Program Coordinator.


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Kingsport Lite 241RB
When you are ready to get away from the pressures of work and get away for a weekend of relaxing and fun, then load up this Kingsport Ultra-Lite 241RB travel trailer by Gulf Stream Coach and let your relaxation begin!
As you enter the travel trailer, straight in front of you there is a sofa that is facing the rear of the trailer. The kitchen area has a double kitchen sink, a three burner range, and refrigerator. There are also overhead cabinets where you can store dishes. The dinette is found along the opposite side of the trailer. Above the dinette you will find an overhead cabinet where you can store books or games, or other personal belongings. Right next to the entrance door there is a little shelf.
The front bedroom has a queen bed with wardrobes on either side of the bed. Above the bed you will find an overhead shelf for storage.
Located in the rear of the trailer is the bathroom. Inside you will find a corner shower, toilet, sink, medicine cabinet, and a bit more counter space.
Outside of the trailer there is a pass through storage area which is ideal for stowing all of your exterior camping gear when not in use, plus so much more!Have a question about this floorplan?Contact Us
Sleeps 4 Length 26 ft 11 in Ext Width 8 ft Ext Height 9 ft 6 in Int Height 6 ft 4 in Hitch Weight 490 lbs Dry Weight 4090 lbs Cargo Weight 2320 lbs Fresh Water Capacity 30 gals Grey Water Capacity 36 gals Black Water Capacity 36 gals Furnace BTU 16000 btu
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When the sun threatens to fry your melon, source solace and keep on fishing in Simms' long-billed, five-panel Flats Cap. Lightweight, durable lids include a 100-percent nylon shell and an adjustable hook-and-loop closure to seal the deal. One size fits most.
- 5 panel cap
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- Long bill visor length


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Newman University regression analysis
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Learn about Newman University regression analysis, and registering for discussion sections. Which college degrees give you the best chances of finding employment after graduation? To earn a higher salary, compare accredited engineering concentrations, and research technical certificate programs in your chosen field. Concentrating on Newman University regression analysis, for example, you may gain an advantage in job recruiting on-campus. Check with the mathematics department for course registration deadlines, and regression theory program requirements. Please use the form above to request admissions info for Newman University.
While a math degree may not seem like a path to wealth at first glance, many fields are based almost entirely on a math foundation. For instance, both physics as well as engineering make use of algebraic formulas to determine motion and forces on objects, and the stress on materials. In business, financial accounting and stock investing count on the mathematical principle of compound interest over time. Math classes may be refocused toward practical applications, such as numerical analytics of big data online or statistical interpretation of scientific research results. Further, financial engineers or 'quants' may be called upon to prepare math-based reports for financial management, in order to develop high-speed, stock investment algorithms.
Finally, there is a lot of mathematical calculation behind complex decisions such as whether a business should raise money by issuing stock directly to the public as in the case of Google, or seek long-term loan financing? Both decisions involve quantification of risk and substantial probability analysis. A discount rate is used to determine the present value of the expected returns, and if a business anticipates being highly profitable in the short-term, it may be wiser to take out a bank loan, rather than dilute ownership via exanding the number of shares outstanding. Beyond major requirements within the mathematics department, you may consider Ranney School EECS department ranking as an adjunct to your primary course of study.
Electrical Engineer {PE}
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_Electrical Engineer {PE}_*. *Bachelor's Degree in Electrical Engineering. Mid-high Rise Electrical New construction projects..
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We currently have an opportunity for an Engineer supporting work at the customer site in. Is a leading provider of consulting, engineering, and technical..
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Perform electrical work orders. E) Replace electrical solenoid valve. The Engineer repairs and maintains facility buildings and equipment.
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Welcome to Archimedes Academy of Divergent Thinking!
Archimedes Academy is a virtual fellowship of learning founded by a mother and son who embarked upon their shared, self-directed, non-institutional educational journey in 2013. Sometimes, for brevity, we'll describe ourselves as home schoolers.
We don't tie a physical location to the process of learning. Home schooling, home education, or learning at home—I would rank these labels as decent, better, best, but still fundamentally inaccurate.
It's trite to say the world is our classroom. It's better to say we don't need a classroom to learn.


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an interesting recall of a dream i had years ago, a dream which may help me to choose what i will do IF i am still alive by summer of next year.
the dream;
---a voice merely appeared in my dream, off in a visual distance was a city skyline, far far off away.
voice says...
"people on the ADEPT path, must *never* live in cities: they must live near college towns"
as i left the library of FSU, and walked to the relative queit of the downtown, maybe a mile away, i felt drained..today. ought to, i guess as there is an enrollment this year of 35,000!! this lethergy reminded me when i lived with my sister out in the country and she had that typing service in town, a college town of a school of 15,000+. my job was to post the bullitin boards with her ads.
all over campus and when i was done, a one hour nap was manditory! drained.
there IS such a state as being a "psychic empath"! i am that, i guess, thus the counsel of that dream!!
"adept" would mean someone with "psychic powers and sensitivity". that is I.
greatly so, this is something that always catches me by ego-surprise!! do i EVER learn?!
and i can well see the wisdom of the "college town", as "strange people are more accepted there. just imagine me moving to a archtypical tennessee mountain town where even people who move there from one valley over are considered to be Outsiders and to be measured and found Wanting!
[i would give this rambling post to anyone out there who is finding that they are more psychic than their friends and at about 20---25 or so, this develops. pick up auras of anyone around ya. become more feeling of the person's aura at the table next to you than even that person is of his/her own feelings! ]
only this means that i must move to my childhood home town area as i am accepted there!!
[you would NOT want to know how much it snows there in a year! i said "year' not winter!!! they have more white Easters than most places have white Christmasses!!]
pschic empath....that means in the presence of several people; one's aura is like of a car battery and someone lays a huge wet cresent wrench across both terminals and leaves it there for a day! drained. almost like that "chronic tiredness syndrome"
oh tallahassee, long live tallahassee: most excellant when it had 20,000 people...now it has 250,000 and growing!
the mating call of the distant chainsaws draws Suiters to come to mate: malls are the Larvae offspring of this mating between chainsaw and developers!
but maybe CARS are!!
so if i live a bit longer, i may have little choice but to move.....as i grow older and more sensitive....


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