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Exercise promotes cardioprotection in both humans and animals not only by reducing risk factors associated with cardiovascular disease but by reducing myocardial infarction and improving survival following ischemia. This article will define the role that nitric oxide and β-adrenergic receptors play in mediating the cardioprotective effects of exercise in the setting of ischemia-reperfusion injury.
Cardiovascular disease (CVD) refers to any disease that affects the cardiovascular system, including cardiac disease, vascular diseases of the brain and kidney, and peripheral artery disease. CVD continues to be a leading cause of mortality and morbidity in the world despite advances in health care practices. In the U.S. alone, it is estimated that one in three adults (roughly 82,600,000) have one or more types of CVD. Economically, it is estimated that about $500 billion is spent each year for the costs associated with treating patients suffering from CVD (58). As such, the development and implementation of therapeutic strategies to combat CVD remains an unmet need.
Age, gender, and genetics are certainly important risk factors associated with the development of CVD. However, the modern lifestyle has become an apparent risk factor. This sedentary lifestyle includes a high incidence of smoking and consists of a diet comprised mainly of saturated fats and sugar and devoid of fruits and vegetables. As a result, hypertension, hyperlipidemia, insulin resistance, obesity, and diabetes are major risk factors for the development of CVD. The good news is that, for the most part, with the exception of age, gender, and genetics, the other major risk factors for developing CVD can be targeted with preventive measures. For instance, numerous studies have linked a reduction in the rate of initial coronary artery disease events in physically active individuals (61). Coupling this with the experimental and clinical evidence demonstrating the cardioprotective effects of regular activity (9) provides a strong body of evidence that exercise reduces the risk of CVD events (39). This has resulted in an increasing awareness among physicians and the community as a whole that regular exercise results in a healthier lifestyle and leads to a reduction in the incidence of stroke and heart attack. Therefore, a better understanding of the molecular and cellular mechanisms by which exercise promotes cardiovascular health (prevention and cardioprotection) are required to develop therapeutic strategies to reduce CVD risk and to treat individuals who experience a major CVD event (12). This article will highlight recent findings regarding the role that endogenous nitric oxide (NO) and β-adrenergic receptors (β-ARs) play in mediating the cardioprotective effects of exercise in the setting of myocardial ischemia-reperfusion (I/R) injury.
Cardioprotective Effects of Exercise
Studies have reported that regular, physical exercise promotes cardiovascular health and reduces the risk of mortality associated with cardiovascular disease (21, 56). Currently, the precise mechanisms by which exercise promotes cardioprotection are not completely known. However, there is evidence to suggest that exercise reduces risk factors associated with CVD, such as obesity and elevated blood pressure, among others (7). Importantly, the protective effects of exercise are not always associated with risk reduction (21, 61). This is exemplified in animal models, which are devoid of confounding risk factors for cardiovascular disease, where exercise has consistently been shown to improve coronary vascular reactivity, decrease myocardial stunning, and reduce arrhythmias in hearts subjected to I/R injury (26). Moreover, exercise confers sustainable protection against myocardial infarction following both long-term and short-term training regimens (9) and improves survival after an ischemic event in humans (37, 50). A review of the literature indicates that reductions in cell death following exercise range from 4 to 75% depending on the ischemic model studied (permanent ischemia or I/R) and the training strategy employed (1, 6–8, 13, 16, 27, 35, 47, 71, 72, 74, 75, 77) (Table 1). Combining the results from these studies reveals that, on average, exercise training reduces injury by 34% compared with nontrained groups.
Putative Cardioprotective Mechanisms of Exercise
In a recent review article, Frasier et al. (26) posed a simple question: "Is exercise the same as preconditioning?" Based on the existing evidence in the literature, the answer to this question is not all that surprising: Yes, exercise is a form of preconditioning. Murry and colleagues (51) were the first to demonstrate the preconditioning phenomenon, which typically refers to the observation that short, discontinuous episodes (i.e., one or more) of ischemia protects tissue against a subsequent prolonged period of ischemia. Importantly, ischemia is not the only stimulus that can precondition tissue, since there is now evidence to suggest that pharmacological agents (15, 67) and interventions such as caloric restriction (62) and exercise (17, 44) also mimic the protective effects of brief ischemic insults. Preconditioning consists of two distinct phases: the initial window of protection and the second window of protection. The first window of protection is transient and lasts for only a few hours. The second window of protection usually appears ∼24 h after the preconditioning stimulus and can last for up to 72 h. Each of these phases is distinct in terms of molecular signaling cascades that are induced (76). Exercise also elicits two windows of protection. This is best exemplified in the study by Yamashita et al. (75) in which rats were subjected to treadmill running for 30 min, after which different groups were subjected to myocardial ischemia from 30 min to 72 h after the end of the training. The authors found that exercise reduced the degree of myocardial infarction in a biphasic manner. Specifically, protection was seen 30 min after the end of the training session but was lost at 24 h only to return again at 36 to 60 h after the cessation of running. Importantly, as mentioned above, the protective effects of exercise even extend to 9 days after the ending of an 8-day training period.
The cardioprotective actions of exercise training have been ascribed to its ability to increase a number of proteins associated with preconditioning. For example, studies have reported an increase in the expression of superoxide dismutase (7), catalase (44), and heat-shock proteins (HSPs) (44, 48) after exercise. Others reported that exercise increases the expression and activity of endothelial NO synthase (eNOS), resulting in an increase in NO levels (1). Still others report that exercise activates ATP-sensitive potassium channels (sarcolemmal and mitochondrial) in cardiovascular tissues (6, 57). Moreover, the type of exercise also influences the cytoprotective signaling cascades that are activated. Both treadmill running and voluntary wheel running increase the phosphorylation of AMP-activated protein kinase (17); however, voluntary wheel running does not alter the expression of HSP72, whereas treadmill running has been shown to increase its expression (44). At present, the precise molecular signaling mechanisms that mediate the cardioprotective effects of exercise remain unresolved. Moreover, additional research efforts are required to define the best strategy to elicit these mechanisms.
NO Metabolites Mediate the Cardioprotective Effects of Exercise
An intriguing finding regarding the cardioprotective effects of exercise relates to the sustainability of the protective effects. Specifically, studies have shown that the cardioprotective effects of exercise are not restricted to the training phase. In other words, exercise training protects the heart against ischemic injury long after the training period has ended. In most cases, studies designed to test the protective effects of exercise involve training for 3 days, 7 days, or up to 12 wk, and then within 24 h of the last exercise session the animals were subjected to myocardial ischemia. Yamashita et al. (75) noticed that delaying the time between a single treadmill training session (30 min) and the onset of ischemia to 36, 48, or even 60 h resulted in similar degrees of infarct size reduction compared with animals subjected to ischemia right after the training session. This was further confirmed by in a study by Lennon et al. (44). In this study, male rats were subjected treadmill running for 8 days. Different groups were then rested for 1, 3, 9, and 18 days after the last exercise session. At these time points, global myocardial ischemia was induced using the Langendorff-perfused hanging heart model. The authors found similar reductions in I/R injury in the hearts from the rats that were rested for 1, 3, and 9 days. However, protection was lost in the hearts from the rats rested for 18 days. In terms of the mechanism responsible for the protection, exercise was found to induce an increase in both catalase activity and HSP72 levels in the rats that rested for 1 and 3 days. However, by 9 days of rest, both catalase and HSP72 levels had returned to sedentary levels, suggesting that an additional mechanism contributed to the observed protection (44).
Recently, we reported that the sustainable cardioprotective effects of exercise were also evident after voluntary wheel running (13). In our study, mice were housed in cages with a running wheel and allowed to exercise voluntarily (VE) for 4 wk. Mice in the VE group and the sedentary control group were then subjected to myocardial I/R injury 24 h or 1 wk after the cessation of training. We determined that both groups of VE mice (i.e., 1 day or 1 wk posttraining) displayed a similar reduction in myocardial infarct size compared with sedentary control mice, which supported the previous findings regarding the sustainability of the cardioprotective effects of exercise. Initially, we evaluated the expression of several proteins suggested to mediate exercise-induced cardioprotection, AMPK and SOD. Both were increased in the heart immediately after the end of the exercise-training period but returned to baseline levels by 1 wk after training. This suggests that AMPK and SOD may play a role in mediating the cardioprotective effects of exercise in the acute period but do not play a role in maintaining the sustainable cardioprotective effects of exercise.
The endothelium is critically involved in exercise-induced cardioprotection. For instance, exercise increases vascular shear stress throughout the body, which in turn increases the expression and activity of eNOS, resulting in an increase in NO in both animal models and humans (18, 33, 34, 60). An important role for eNOS/NO in exercise physiology was established in studies where mice deficient in eNOS were reported to have run to a lesser degree (roughly 65% less) than age-matched, wild-type mice (49, 53). Additionally, studies employing mice deficient in eNOS have confirmed a role for eNOS/NO in mediating the cytoprotective effects of exercise (19, 29). Specifically, in the heart, it has been shown that eNOS is essential for exercise to protect against the development of heart failure, as evidenced by the findings that exercise does not attenuate left ventricular remodeling, hypertrophy, fibrosis, or apoptosis after myocardial infarction in eNOS-deficient mice (19). We, therefore, turned our attention to eNOS and NO to determine whether they played a role in mediating the sustainable cardioprotective effects of exercise. Similar to previous studies (1, 38, 60), we found that exercise training altered the expression and activity of eNOS, resulting in an increase in NO. Specifically, we found that VE did not alter the expression of total eNOS in the heart. It did, however, increase the phosphorylation of eNOS at serine residue 1177 (activation site) and decrease the phosphorylation of eNOS at threonine residue 495 (inhibition site). Importantly, these changes were evident immediately after the end of the training period and were still present 1 wk after the end of training. We also evaluated the expression and phosphorylation status of eNOS in the skeletal muscle because it is an organ that experiences blood flow changes during exercise. In the skeletal muscle, VE increased the expression of total eNOS and decreased the phosphorylation of eNOS at threonine residue 495. There was an overall increase in the expression of phosphorylated eNOS at 1177 in the skeletal muscle, but this increase was attributed to the increase in total eNOS. In contrast to the heart, the alterations in eNOS expression and phosphorylation status returned to baseline levels by 1 wk after the end of the training. These findings are interesting for several reasons. First, they suggest that exercise alters the expression and phosphorylation status of eNOS in a tissue-specific manner. Second, the degree to which exercise training mediates the changes in eNOS is also tissue-specific. Finally, these findings suggest that the alterations in eNOS play an important role in not only mediating the acute but also the sustained cardioprotective effects of exercise.
Importantly, the changes that we observed in the expression and phosphorylation status of eNOS resulted in an increase in NO levels, as evidenced by an increase in circulating and tissue levels of both nitrite (NO2) and nitrosothiols (RXNO). Nitrite is produced by the oxidation of NO in aerobic conditions (68), whereas nitrosothiols are formed when cysteine thiols in proteins are modified by NO in a process known as S-nitrosylation (25). Classically, blood levels of nitrite and nitrosothiols served as biomarkers of NO bioavailability and as surrogates of endothelial function (40, 78). In recent years, this classic paradigm has shifted as accumulating evidence has come to light demonstrating a physiological role for both nitrite and nitrosothiols. Nitrite is widely considered a storage form of NO in both blood and tissues (20, 43) that is very readily converted into NO by either acid reduction or by various nitrite reductases during ischemia or hypoxia (59, 68, 79). Importantly, administration of exogenous nitrite modulates cardioprotective signaling in animal models of I/R injury when given before, during, or after ischemia (23, 32, 63, 68). Currently, the exact mechanism(s) by which nitrite elicits its cardioprotective effects are not known. However, there is consensus that nitrite-mediated tissue protection is in large part dependent on the generation of NO (23, 63).
Endogenous nitrosothiols also exert a critical physiological role as well as a pathophysiological role in a variety of human diseases (25). S-nitrosylation of myocardial target proteins associated with β-adrenergic receptor signaling and/or calcium handling influences the contraction of the heart (31, 54, 69). In regard to pathophysiology, increasing the S-nitrosylation of proteins during myocardial I/R can attenuate a number of adverse processes (10, 36, 64), such as apoptosis (46) and inflammation (14), and even stimulate protective processes like angiogenesis (45). Specifically, S-nitrosylation of N-ethylmaleimide-sensitive factor inhibits endothelial cell exocytosis and neutrophil infiltration following myocardial I/R (73). Additionally, S-nitrosylation of cyclophilin D prevents the opening of the mitochondrial permeability transition pore (MPTP) (52). Finally, caspase-3-like activity can be inhibited via protein S-nitrosylation (41), which will also contribute to less cell death following myocardial I/R. Interestingly, nitrite via its reduction to NO can also form nitrosothiols and thereby modify complex I of the mitochondrial transport chain, resulting in a reduction of reactive oxygen species generation during early reperfusion (63).
Circulating levels of nitrite and nitrosothiols are elevated during exercise in both rodents and humans (6, 78). However, under the traditional view regarding the physiological role of these NO metabolites, an increase was just considered evidence that NO production was increased. As such, what role if any they played in mediating the cardioprotective effects of exercise was overlooked. In our recent study (13), we provided evidence that the formation of nitrite and nitrosothiols during exercise training contributes, in part, to the acute and sustained cardioprotective effects of exercise (FIGURE 1). In regard to the acute effects, we observed an increase in plasma, skeletal muscle, and heart levels of nitrite and nitrosothiols immediately after the end of the training period. The finding that the blood and myocardial of nitrite and nitrosothiols levels were significantly increased before myocardial ischemia is an important observation given that eNOS activity and NO bioavailability are attenuated during ischemia following increased production of reactive oxygen species (30, 68). Therefore, during myocardial ischemia, the nitrite stored following exercise can be converted into NO by any of the identified nitrite reductases found in the heart. Similarly, previously stored nitrosothiols prevent the irreversible oxidation of proteins by acting as a reversible protective cap during I/R and also by acting as a redox-sensitive NO donor (36). The increased NO generated in an NOS-independent manner from either nitrite or nitrosothiols serves as a crucial cytoprotective signaling molecule that protects the heart and circulation against myocardial I/R injury. As such, these findings suggest that NO derived from both nitrite and nitrosothiols more than likely contributes to the acute cardioprotective effects of exercise. This is supported by the findings that the infarct-lowering effects of exercise were lost in eNOS-deficient mice. Our findings also suggest that skeletal muscle may serve as a source of NO to protect the heart against myocardial I/R injury. This is based on our previous findings that nitrite and nitrosothiols exert endocrine actions and NO that can be generated in one organ is transported via the circulation in the form of nitrite and/or nitrosothiols to protect another organ against I/R injury (24). We found that nitrite and nitrosothiols levels remained elevated in the hearts of trained mice for 1 wk after the end of the training period. Further evidence supporting a role for nitrite and nitrosothiols stems from our recent findings that, when mice were recovered for 4 wk after training, both nitrite and nitrosothiol levels returned to baseline levels and cardioprotection was ablated. Finally, we extended our investigation into humans and found that nitrosothiols, not nitrite, levels were elevated in the plasma of trained endurance athletes (12). This suggests that nitrosothiols may play a more prominent role in mediating protection during exercise given that both nitrite and NO can form nitrosothiols (11). However, further work investigating larger pools of human samples is needed to test this hypothesis.
Our findings and those of others clearly demonstrate that eNOS and eNOS-derived NO metabolites play a critial role in mediating both the acute and sustained cardioprotective effects of exercise. However, there are questions that remain to be answered. For instance, 1) what is the signaling mechanism by which the alterations in eNOS phosphorylation status remain for 1 wk after the cessation of training? 2) What duration and intensity of exercise is required to increase the steady-state levels of nitrite and nitrosothiols in the heart? 3) Do the increased levels of heart nitrite and nitrosothiols remain after eNOS activity returns to normal, and, if so, how long? Additionally, given that our present study provides the only data to suggest that eNOS and NO metabolites (i.e., nitrite and nitrosothiols) play a role in mediating the sustained cardioprotective effects of exercise, more work with loss-of-function and/or NO scavenging experiments is needed to definitively test this hypothesis. It is also important to determine whether other types of exercise have the same effect on eNOS and NO metabolites.
β-Adrenergic Receptors Mediate Exercise-Induced Cardioprotection via NO
β-Adrenergic receptors (β-ARs) belong to a superfamily of G-protein-coupled receptors and regulate cardiac function in response to catecholamines (28). In the heart, there are three isoforms of β-ARs: β1-AR, β2-AR, and β3-AR (66). The physiological roles of the β1- and β2-ARs in the myocardium have been studied extensively. For instance, it is established that stimulation of β1-ARs leads to increases in the rate of contraction and the force of contraction, as well as an acceleration of relaxation. In regard to stimulation of the β3-AR in the heart, the exact physiological and pathophysiological roles are not known. However, there is evidence to suggest that stimulation of the β3-AR induces the production of NO from eNOS to elicit a negative inotropic effect (66). Along these lines, we (13) found that the activation of eNOS (i.e., phosphorylation) and generation of NO in response to exercise is mediated in part by stimulation of the β3-AR. Specifically, we observed sustained and significant elevations in circulating catecholamines following voluntary exercise in mice coupled with increased myocardial expression of the β3-AR in the absence of alterations in β1- and β2-AR expression. Interestingly, we also observed significant eNOS activation and NO generation following a single injection of physiolgoical levels of epinephrine (13). Furthermore, we found that exercise failed to result in eNOS activation or increase plasma and heart levels of NO metabolites in mice with genetic deficiency of the β3-AR. Similar to eNOS-deficient mice, β3-AR-deficient mice also exercised to a lesser degree than wild-type control mice, which suggests that β3-ARs are important mediators of the physiological response to exercise in addition to their role in exercise-mediated cardioprotection. Furthermore, β3-AR is important for exercise-mediated cardioprotection, as evidenced by the finding that β3-AR-deficient mice displayed exacerbated myocardial injury when subjected to I/R injury following the completion of a 4-wk exercise period. On the basis of these results, it can be suggested that increased catecholamine levels during exercise lead to increased β3-AR stimulation, which in turn through downstream signaling activates eNOS. The resultant increase in NO bioavailability can then protect the heart against ischemic injury as described above (FIGURE 2). The exact mechanism by which β3-ARs are linked to eNOS activation is not completely understood. However, there is evidence from in vitro experiments with endothelial cells to suggest that stimulation of the β3-AR activates eNOS via a Rac1-PKA-Akt pathway (42). Given that Akt has been shown to regulate eNOS activation in response to exercise (3) and that Rac1 is activated in contracting skeletal muscle (65) and by shear stress (70), it is possible that this pathway regulates links of β3-ARs to eNOS during exercise. However, this pathway has not been definitively tested in response to exercise, so further work is needed to elucidate the mechanism(s) by which the β3-AR stimulation regulates eNOS in response to exercise. Additionally, further work is required to determine the mechanism(s) by which deficiency in β3-ARs leads to exacerbated myocardial injury after training.
It is also possible that increased sympathetic activation and increased catecholamine release during exercise may result in activation of the β2-AR receptor on endothelium or cardiac myocyte to upregulate eNOS function and NO signaling (FIGURE 2). Recent experimental evidence demonstrates that stimulation of β2-ARs activates eNOS via a Src kinase-PI3K/Akt-dependent but cAMP/PKA-, MAPK-, and AMPK-independent pathway (2). Additionally, activation of the β2-AR promotes eNOS activation, increased NO metabolites, and myocardial protection following I/R in mice (4). However, the precise role or potential mechanism by which β2-AR activation mediates exercise-induced cardioprotection has not been investigated.
Perspective and Conclusions
Despite the well documented beneficial cardiovascular effects of exercise training, our understanding of the protective mechanisms elicited by exercise (5), especially as it relates to myocardial I/R injury, remains largely unknown. As documented above and in other studies, exercise is a preconditioning modality, as evidenced by the findings that exercise induces a number of classic preconditioning signals. However, in regard to other preconditioning strategies, exercise is unique in that it can elicit sustainable protection that extends well beyond the training period. As such, exercise remains an fascinating approach to diminish the severity of myocardial infarction following ischemic injury given that it is widely accessible to almost all patient populations, is relatively inexpensive, and is safe (12). Therefore, continued investigation into the unknown cardioprotective mechanisms of exercise are extremely important given their enormous health care implications. Specifically, a better understanding of the signaling cascades induced by exercise will hopefully provide the framework for developing therapeutic strategies designed to mimic the cardioprotective effects of exercise.
This work was supported by grants from the National Heart, Lung, and Blood Institute (5R01 HL-092141, 5R01 HL-093579, 1U24 HL-094373, and 1P20 HL-113452 to D. J. Lefer and 5R01 HL-098481 to J. W. Calvert). We are also grateful for the generous funding support from the Carlyle Fraser Heart Center of Emory University Hospital Midtown.
No conflicts of interest, financial or otherwise, are declared by the author(s).
- ©2013 Int. Union Physiol. Sci./Am. Physiol. Soc.
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Pics and clips of girls smoking. Name of the girl(s) required in the thread title.
ARCHIVE for girls who have or had their own channel. Note that since June 1st 2012, it is no longer allowed to upload in this section, and new threads are not accepted since May 19, 2013.
Non-Adult Clips YouTube Favorites.
10-18-2017, 04:20
Non-Adult Pics Czech 47/2009 - Pavla
10-21-2017, 12:35

subset: commoncrawl


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wee eddie 09:55 18 Apr 2007
Has McAfee successfully installed, been updated and run? I know this sounds silly but there are some, out there, who have never Updated or Run their Anti Virus?
You make no mention of a Fire Wall.
Has he cleared out all the usual Temporary files and Recycle Bin, Defragmented and then run XP's full Error Checking on his HDD?
None of these is likely to make any difference most of his problems but will start him on the road to a cleaned future.
Remember to tell him to set a Restore Point before making any big alterations. I have been told that it is a good idea, when you know that everything is running smoothly, to clear the Restore Points by turning them "OFF" and rebooting. Remember to turn them on again.


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Rear Schmear
Please Note: We now have an 8 oz. jar that is replacing the 12 oz. jar. (price per jar did lower)
Rear Schmear is a natural ointment for soothing dry and chapped skin. When my oldest was a baby, he had extremely sensitive skin. We tried every cream we could find and nothing would prevent him from having diaper rash. I do not make any claims that it will heal diaper rash, but I promise that it was the only product that prevented diaper rash, which is the primary goal. Only tested on friends/family. Rear schmear also works great on dry elbows, cuticles, and chapped lips.
8 oz.
$16.00 each
Buy 3 - $15 ea. Buy 4 - $14.00 ea. Buy 5 - $13 ea.
3 oz
$9.50 each
Buy 3 - $8.50 ea. Buy 4 - $8 ea. Buy 5 - $7.50 ea.


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JOHN R. de LAETER, PhD, DSc, is Professor Emeritus of Physics in the Department of Applied Physics at the Curtin University of Technology, Western Australia.
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Ah, I was planning on just repainting the hubs and lacing them to gsports
Depends, what kind?
I love my Hero 2.
I agree, New ones are coming soon
Thanks. Those were nice.
stripped profile crank arm splines stripped haro stem cracked chris king headset cracked haro seatstay cracked fly bikes diablo seatstays bent fly diablo 3 top tube bent haro backtrails forks broke teeth off animal v2 sprocket dented shadow crowgora ... more »
Thanks. Yea, I'm relacing the rear soon
This forum thread has 11 replies
This setup has 8 comments.
Yea, I haven't heard anything bad about them
This setup has 8 comments.
I like them, super strong but a bit expensive
This setup has 8 comments.


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Jq-Tiles is an image gallery plugin with CSS3 Effects. The tile effects can be customized in various ways: number of tiles in x/y axis, fadingRead more
Admin Theme with Twitter Bootstrap – Charisma
Twitter bootstrap is a very nice framework from building resposive websites and templates. It reduces huge amount of development time for creating a responsive websiteRead more
Javascirpt Parallax Animation Library – Jarallax
Jarallax is a nice feature rich parallax animation library using javascript and jQuery. This library allows to create easy and simple parallax animations using javascript. ThisRead more
Jquery Responsive Slider – iView Slider
Responsive jQuery Slider Plugin for image slider, image gallery, banner rotator with HTML5 transition support. Free Download Jquery Responsive slider.Read more
Redactor – A modern WYSIWYG Editor with jQuery
Redactor is a jQuery Powered WYSIWYG editor with a clean and modern looking interface. It converts the standard textarea into an editor and the editorRead more
Transparency – A Minimal Template Engine For jQuery
Transparency is a minimal template engine for jQuery. It really helps to make HTML code parts from JSON. It maps JSON objects to DOM elementsRead more
Ajaxify Standard Forms Instantly – ALAJAX
Now a days Javascript frameworks like Jquery, Mootools are essential to every webdevelopment environment. The frameworks make javascript programming easier. It not only reduces theRead more
Jquery Slider with Keyboard and Mouse Control – Rhino Slider
Rhinoslider is one of the most flexible jQuery slider plugin that can handle not only Images but also HTML element (text, videos, etc.). Rhino sliderRead more
Flexigrid 1.1 Implementation on Codeigniter 2.10
Flexigrid is a light weight jquery plugin with an ajax loading grid. This is excellent for handling various kinds of data. A codeigniter implementation wasRead more
Image Hover Effects With jQuery Plugin Adipoli
Hover Effects for a website make it a fresh look. There are lot of jquery plugins to implement hover effects. For Images the hover effectRead more
20 Jquery Plugin for Image sliders and Accordians – Cool Carousels
There are lot of jquery plugins available for image sliders and accordians. Fred Heusschen, a talented frontend web developer developed a set of 20 differentRead more
Jquery Plugin for HTML5 File Upload
After the introduction of HTML5 the multiple file upload without flash script is possible. jQuery File Upload is a nice plugin for handling multiple fileRead more


text:
Rangers look to de Boers return
IN SOME conflicts, medals are handed out for bravery. Alex McLeish, however, would simply settle for a point as a reward for standing up in the face of overwhelming odds.
When the "Battle of Britain" resumes in 12 days' time at Old Trafford, the Rangers manager knows his team must earn something from the second encounter with Manchester United to sustain hopes of progress from group E.
As courageous as Rangers' display was on Wednesday night, and McLeish's players deserved his description of "a brave performance" it will mean nothing unless they return up the M6 with something tangible. Many will have woken yesterday morning and immediately felt the nagging realisation that an opportunity was missed amid the soaring partisan decibel count that engulfed Ibrox.


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Subsidiary power in multinational corporations: the subtle role of micro-political bargaining power
Purpose ‐ As subsidiary power has received relatively little attention in existing research, this paper aims to enhance the understanding of genuine sources of subsidiary power and how they work in headquarters-subsidiary relationships. Design/methodology/approach ‐ The paper is based on a review of the relevant literature and four illustrative case studies, which are written on the basis of secondary sources. Each case was selected because it adequately represents a particular type of power. This allows for cross-case comparisons of the strengths and sustainability of different types of power, and facilitates the exploration of the application of subsidiary power in headquarters-subsidiary relationships. Findings ‐ Four genuine types of subsidiary power are identified. One of these ‐ micro-political bargaining power ‐ plays a subtle but crucial role, as it is important in the enactment of the three other types of power, i.e. systemic, resource-dependency, and institutional. Practical implications ‐ As headquarters have unlimited access to formal power, subsidiaries find it necessary to constantly apply micro-political bargaining power. The empirical material suggests that the effectiveness of micro-political bargaining power for subsidiary actors is based on two factors: information retrieval from headquarters and the leveraging of such information in issue-selling or conflict-handling processes. Originality/value ‐ The paper contributes by theoretically delineating genuine types of subsidiary power and by illustrating the strength, sustainability and interaction of these types of power in headquarters-subsidiary relationships.
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Keywords: Intergroup relations; Politics; Subsidiaries
Document Type: Research Article
Publication date: 2011-02-01


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Risks Specific to Ridgemont Outfitters
1. Ridgemont already has revenue but not enough to cover existing expenses. There are two revenue streams, 1. wholesale sales to national & international retailers and distributors and 2. direct retail sales to e-commerce consumers through our website. The gross margin on combined sales is close to covering expenses and an increase in revenue will make that possible. There is a risk that sales will not grow enough to cover overheads.
2. Whilst wholesale sales are growing and Ridgemont has attracted some good retailers to partner with from Summer 2017, there is a risk that product may not sell through in-store as quickly as anticipated and retailers may choose other brands and/or discount product to de-value the brands. In addition there is also a risk that the retailers may fail without paying for supplied product. Ridgemont has an agreement in place with a New York based factoring company and intends to only supply retailers that it can credit insure to alleviate the risk of non-payment.
3. There are production risks that we will not be able to supply product to meet demand due to factory issues in Southern China including poor quality and factories going out of business. However the senior management have extensive experience of producing footwear & apparel in the area and in addition Ridgemont employs a locally based agent who has 30 years experience in Southern China footwear production.
4. Competition in the outdoor footwear market is strong and there are many well know established brands. Whilst Ridgemont represents a different approach to technical outdoor footwear there is a risk that the established brands will copy its approach and use their larger distribution network and marketing power to force Ridgemont out of the wholesale market. However with the introduction of direct to consumer sales and marketing as well as the appetite to champion smaller brands among the public, Ridgemont should still be successful.


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Filter Results:
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- Last 5 years (6)
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- Lise T Gustad, Lars E Laugsand, Imre Janszky, Håvard Dalen, Ottar Bjerkeset
- European journal of heart failure
- 2014
AIMS Symptoms of anxiety and depression often co-exist with cardiovascular disease, yet little is known about the prospective risk for heart failure (HF) in people with symptoms of depression and anxiety. We aimed to study these prospective associations using self-reported symptoms of anxiety, depression, and mixed symptoms of anxiety and depression (MSAD)… (More)
- Lise T Gustad, Wendy Chaboyer, Marianne Wallis
- Intensive & critical care nursing
- 2005
Intensive Care Unit (ICU) patients are often not able to respond to long self-report instruments, therefore, in order to assess anxiety accurately, a short and easy to use measure is required. The Faces Anxiety Scale (FAS) developed by McKinley et al. [McKinley S, Coote K, Stein-Parbury J. Development and testing of a faces scale for the assessment of… (More)
- Lise Tuset Gustad, Wendy Chaboyer, Marianne Wallis
- Australian critical care : official journal of…
- 2008
OBJECTIVE The purpose of this study was to quantify the levels of anxiety experienced by Intensive Care Unit (ICU) patients just before transfer to the ward and then twice after transfer to the ward in order to test the hypothesis that anxiety levels would change over the three data collection periods. DESIGN A prospective, repeated measure cohort study.… (More)
- Malvin Torsvik, Lise Tuset Gustad, +4 authors Erik Solligård
- Critical care
- 2016
BACKGROUND Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less focus on the effect on patient outcome with better observation and treatment at the ward level. METHODS This was a before-and-after… (More)
- Lise Tuset Gustad, Lars Erik Laugsand, Imre Janszky, Håvard Dalen, Ottar Bjerkeset
- European heart journal
- 2014
AIMS The nature of the association of depression and anxiety with risk for acute myocardial infarction (AMI) remains unclear. We aimed to study the prospective association of single and recurrent self-reported symptoms of anxiety and depression with a risk of AMI in a large Norwegian population based cohort. METHODS AND RESULTS In the second wave of the… (More)
The multiple-dose, dose-response curve of MK-927 was studied in a five-center, double-masked, randomized, placebo-controlled, parallel study of 2%, 1%, and 0.5% MK-927 in 76 patients with bilateral primary open angle glaucoma or ocular hypertension and intraocular pressure greater than 24 mm Hg following washout of ocular hypotensive medications. Patients… (More)
- Guri H Gundersen, Tone M Norekvål, +5 authors Håvard Dalen
- BMJ open
- 2017
OBJECTIVES We aimed to study whether patient-reported outcomes, measured by quality of life (QoL) and functional class, are sensitive to pleural effusion (PLE) in patients with heart failure (HF), and to study changes in QoL and functional class during follow-up of PLE. METHODS A cohort of 62 patients from an outpatient HF clinic was included. The amount… (More)
- Åsa Askim, Florentin Moser, +7 authors Erik Solligård
- Scandinavian journal of trauma, resuscitation and…
- 2017
BACKGROUND We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared to traditional SIRS criteria or our triage system; the Rapid Emergency Triage and Treatment System (RETTS). METHODS The study was an observational cohort study performed at one Emergency Department (ED) in an urban… (More)
- L T Gustad, O Bjerkeset, L B Strand, I Janszky, Ø Salvesen, H Dalen
- Open heart
- 2016
OBJECTIVE Symptoms of anxiety and depression often co-exist with cardiovascular disease (CVD), yet little is known about the association with left ventricular (LV) subclinical dysfunction. We aimed to study the cross-sectional associations of previous, current and repeated depression or anxiety symptoms, with sensitive indices of LV systolic and diastolic… (More)
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- 1
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text: Professional Conference * Deadline extended to September 29th * * Deadline extended to September 29th * FlyerRegistrationPresentersPamela Voss-Page, M.ED., is a master educator, prevention program developer and Executive Director with Student Leadership Services, Inc. (SLS). Pam synthesizes prevention principles, human development principles, sound education practices and youth-led approaches in proven effective school-based programming. SLS program evaluation and Validation Studies (2011-2016) lead to national recognition and replication of SLS programs. Dawn Flood, LMSW is the Student Leadership Services, Inc. (SLS) Program Director. Since 2004, Dawn trains students, SLS chapter advisors and school administration in Professional Development trainings to implement effective peer education and youth capacity building. Dawn combines her School Social Work, Cognitive Behavioral Approach, experience as Substance Abuse Educator at Saginaw Valley State University, and SLS experience to "change thoughts (cognitive), change actions (behavior) and build skills." Lisa Ficker, PhD is a clinical psychologist and Research Associate with Merrill Palmer Skillman Institute of Child and Family Development at Wayne State University. She has a background in substance abuse prevention, motivational interviewing, and program evaluation. She has been working with Students Leading Students for the past six years as serves as research lead in documenting the success of the Students Leading Students innovative program. Robert Elam-Moore, SLS Alumnus, Crisis worker at Allegan County Community Mental Health; twenty years experience in both treatment and prevention. Robert specializes in LGBTQQ2IA issues. He is a "favorite" among SLS students and advisors. Monica Marie Jones is a Trainer and Field Consultant for the David P. Weikart Center for Youth Program Quality. She is also the Lead Trainer and Quality Coach for The Youth Development Resource Center in Detroit. Her experience includes creating youth development training content as well as work as a teacher and after school program director. She works as a quality coach with the Youth Driven Spaces Immersion Program as well as an Out of School Time Intermediary Coach for the Wallace Foundation's Partnership for Social and Emotional Learning. Monica received her Bachelors degree in Elementary Education from Eastern Michigan University and her Masters of Social Work from the University of Michigan.


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Episode 15: Ameal Cameron
May 1, 2017
We were joined by the infinitely talented, soulful Ameal Cameron. His youthful nostalgic blend of motown and R&B vibes as a singer-songwriter put him on a path all his own. Be prepared for some lilting falsetto and hooks that won't leave your head for at least the next week.
We hope you enjoy!
Don't forget to submit a review on iTunes and subscribe!


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Today's Top Alzheimer's News
ICYMI: A June 14, 2017 STAT News opinion piece by UsAgainstAlzheimer's board members, Dr. David Satcher and Dr. William Vega, was picked up by Raw Story. The piece underscores the need to address Alzheimer's in communities of color.
A June 15, 2017 Alzheimer's News Today article looked at six future tests that could detect Alzheimer's before it becomes too advanced, allowing doctors to aggressively treat the disease to slow down progression and preserve the patient's quality of life. They include testing for: biological markers, brain scans, cerebrospinal fluid protein, blood proteins, gene risks and mild cognitive impairment.
A June 14, 2017 Missoulian opinion piece by Dick Blank from Missoula encourages the new Representative-elect, Greg Gianforte, to prioritize and maintain efforts to end Alzheimer's disease. Blank was the primary caregiver for his wife of 50 years, who lived with early-onset Alzheimer's for over 10 years.
A June 14, 2017 KXAN article reported on an expanded Alzheimer's study looking specifically at Mexican-Americans. Dell Medical School and Seton Healthcare was awarded $800,000 for the new multi-year, statewide (Texas) study. Mexican-Americans have a higher risk of Alzheimer's and other diseases like high blood pressure and diabetes. "One question to ask: is the high Alzheimer's risk due to high blood pressure and diabetes or is it due to different genetic factors we haven't identified yet?" said Dr. John Bertelson, who is spearheading the study.
A June 14, 2017 The San Diego Union-Tribune article spotlighted Mary Ball, Chief Executive of Alzheimer's San Diego, who is moving to Scripps Mercy Hospital Foundation next week. "I'm most proud of the team here at Alzheimer's San Diego and all that we have accomplished together to serve the community," Ball said.
The Henry J. Kaiser Family Foundation created an infographic, Medicaid's Role For Seniors, to assist the 47.5 million Americans age 65 and older.


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2015 Côte de Brouilly, Les Sept Vignes, Château Thivin
Red | Ready, but will keep | Chateau Thivin | Code: 41597 | 2015 | France > Beaujolais > Brouilly | Gamay | Medium Bodied, Dry | 13.5 % alcohol
For proof positive of the capacity of Beaujolais to supply world class wines at an affordable price, look no further than Château Thivin, in Côte de Brouilly. Sept vignes is, ostensibly, the domaine's most "basic" cuvée, but it shows remarkable complexity and finesse, and will continue to improve over the next decade (and perhaps beyond). It is sourced from seven parcels, with a variety of aspects and soils – mostly blue and pink granite – around the volcanic hill of Brouilly. Approximately a third of the grapes in this cuvée are de-stemmed.
The nose combines flamboyant aromas of strawberry compote, blueberry and more subtle savoury notes, which will become more distinct with the passing years.
The theme of cheerful red and blue fruit continues on the palate. This is riper and less austere than, say, the cuvée Godefroy, but has the same beguiling saline character to the finish.
Try it with carpaccio or tartare de bœuf.
Will Heslop - Wine Buyer
Scores and Reviews
WILLIAMS - In a fine vintage such as 2015, the best Beaujolais producers are capable of Burgundian pinot refinement at very unBurgundian prices: this is stunning value, a keeper with gorgeous summer berries in a sappy, silky, mineral package.
David Williams - The Observer Magazine, 23rd April 2017
You may also like
The Producer
Château Thivin of the Côte de Brouilly appellation in Beaujolais has been in the hands of the Geoffray family since 1877.
Today Claude and Evelyne Geoffray produce several different cuvees depending on the orientation of each parcel as the Côte de Brouilly hill has vines on all of its four sides.
The regular wine blend is known as Sept Vignes (as there are seven different locations for their various plots), while they are increasingly introducing single vineyard cuvees.
Other wines by this producer:
The Grape
A French variety planted predominately in Beaujolais where it is the grape behind everything from light and often acidic Beaujolais Nouveau through to the more serious and well-structured wines from the 10 cru villages. It takes its name from a hamlet just outside Chassagne-Montrachet and was at one stage widely planted on the Côte d`Or. However it was gradually phased out due to its poor yield and supposed poor quality of its wines.
The majority of Gamay wines in Beaujolais are labelled as Beaujolais or Beaujolais-Villages and are deliciously juicy, easy drinking, gulpable wines. Of more interest are the Cru wines from the 10 villages in the north of the region where the soil is predominantly granitic schist and where the vines are planted on gently undulating slopes. These can be well-structured, intensely perfumed wines, redolent of ripe black fruits and, while delicious young, will reward medium term cellaring.
Gamay is also grown in the Touraine region of the Loire where it produces soft, well-balanced, gluggable wines for drinking young.
The Region
Brouilly is the largest and most southerly of the ten Beaujolais Crus as well as also being one of the few not to be named after a local village. Its 1200ha of vineyards curl round the volcanic Mont Brouilly, producing fruity, round, textured wines which can be reasonably tannic and often show earthy notes.
Most should be drunk in 3-4 years but the most age-worthy styles from top producers in top vintages can last up to a decade. It is also the only Cru, along with its sister appellation Côte de Brouilly, to allow grapes other than Gamay to be planted – in this case Chardonnay, Aligoté and Melon de Bourgogne – although few choose to take advantage.
Recommended Producers: Dubost, Alain Michaud


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If you'd like to play a game of Texas Holdem or Omaha against people who make a living off playing cards (professionals), and test your knowledge of the game against some top poker players, Full Tilt Poker is where you should head to. Oh, and did I mention Full Tilt accepts US players?
This poker room has acquired a nice team of professional players to help promote the site. Chris Ferguson, Clonie Gowen, Howard Lederer, and Phil Ivey - among others – will pop in for a tourney or a regular ring game every now and then. What other poker room gives you such opportunities?
Full Tilt Poker is one of the safest poker rooms on the internet - financially speaking – thus you'll be able to rest assured your money is in good hands. If you were considering collusion or any other means of fraud however, you should stay well clear of this room. They have zero tolerance against any kind of fraud. The 128-bit encryption will make sure your money matters are perfectly safe from hackers, and the hand history and chat log verifications Full Tilt runs, will certainly deter any unfair attempts for player collusion.
The software Full Tilt uses, is an in-house creation (they're not the skin of any large poker network) and it's a pretty successful one at that too. It's one of the funniest pieces of poker software you'll ever see in just about any poker room on the web. Players can pick personalized avatars in the shape of goofy cartoon characters, and what's more, they can use these avatars to reflect four kinds of emotions through them. No need for smileys here. Your monkey, shark or Chihuahua will smile, frown and look desperate at the click of a mouse-button. It is true that generally, you want to convey as little information about your emotions as possible in a poker game, but this feature is just too cute and funny to ignore.
The software itself is very stable an reliable, and (even though I tested it using a High Speed connection) I see no reason why it should act funny with slower connections. Simple and functional are the key-words in this respect.
Traffic-wise Full Tilt used to be a modest little poker room, and so it stayed right up to the passing of the UIGEA in 2006. Most of the major online poker rooms controlling huge percentages of US players have closed their doors (or rather servers) to Americans, and Full Tilt took full advantage of the situation. They decided they'd still accept US players and nowadays they boast a whooping number of 30,000 players online in peak hours, and the title of one of the best poker rooms in the world.
Now, for the most important thing: fish rating. In the early days, going at Full Tilt was about as tough as it gets. There were no loose tables around, and making money was just too difficult and tedious a thing to do.
With the demise of Party Poker, as the biggest online poker destination for American players, a flood of fish hit Full Tilt, with an impact that can be felt to this very day. The game has generally loosened up a bit, and even if you don't find a resident maniac at each table, there are still quite a lot of weak players you can profit from.
I'd say, fish-wise Full Tilt is an average poker room.
Full Tilt offers a sizeable first deposit bonus (a match of 100% up to $600) and the good thing about it is, that you need no bonus code to qualify for it. No need to click around different affiliates' sites, all you need to do is deposit and automatically receive the bonus. The release of the bonus will be done according to how many FullTilt Points you earn ( by playing raked hands) in increments of 10% at a time.
Back in the days, it was insanely hard to clear the bonus at Full Tilt, nowadays, however, you can release as much as $18 on every 100 hands played.
There is 24/7 email support at Full Tilt poker, however, I didn't contact them to see how fast they'd reply.
As payment methods, they support Neteller, Firepay, Mastercard, and Epassporte. Money transfer is as safe and smooth as it gets.
Final conclusion: definitely a room where US players can still benefit from the high level of service they've been denied by other leading poker rooms.


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Our Friday hours are: 8:00am - 6:00pm
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Medicine refers to the examination, diagnoses and treatment of a disease or illness through non-surgical means.
Diseases that we can treat medically include:
Veterinary medicine is rather unique compared to other medical professions since veterinarians are extensively trained to deal with illnesses that affect all of the tissues and organs in your pet's body. We know about it from head to tail, inside and out!
Open Feline Health Information in new window
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© 2017 Pine Ridge Veterinary Clinic


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Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
Wells Fargo is a provider of banking, mortgage, investing, credit card, insurance, and consumer and commercial financial services.
Be the first lehighvalleylive.com user to add photos or videos of Wells Fargo Home Mortgage
Start here to bank and pay bills online Wells Fargo provides personal banking, investing services, small business, and commercial banking


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Original sculpted and blended Picasso Calla lily bracelet features on a sterling silver bangle. Swarovski crystal or pearl center. The bangle is a thick sterling silver and available in different sizes to fit your wrist. The bracelet opens and hooks around your wrist rather than through your hand so it fits snug. This simple clean style bracelet looks lovely worn alone.
Flower size: approximately 1 inch long.
Flower size: approximately 1 inch long.
Made to order. Ships in 1-3 business days.


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Tailoring Institutional Portfolios to Each Client's Objectives
PH&N is among Canada's most established institutional asset managers, and has a long-standing reputation for distinctive active management and industry-leading service. Drawing from the full spectrum of RBC Global Asset Management's investment capabilities, we tailor solutions to address each client's unique objectives.
We have been recognized by institutional clients as providing the industry's highest-quality service and named a Greenwich Quality Leader in Canadian Institutional Investment Management Service.
Bringing the world to Canadian institutional portfolios
Our LDI practice is one of the most experienced in Canada
Opportunities to enhance returns, reduce volatility, and generate income
A balanced examination of the merits and shortcomings of active share as a measure of active management
From RBC Global Asset Management's CIO and Chief Economist
Solutions that aim to enhance risk-adjusted returns, reduce volatility, and minimize correlations
Working together to benefit our mutual clients
Waterfront Centre - 20th Floor
200 Burrard Street
Vancouver, British Columbia
V6C 3N5 Canada
RBC Centre - 22nd Floor
155 Wellington St. West
Toronto, Ontario
M5K 3K7 Canada
1 Place Ville Marie
6th Floor, North Wing
Montréal, Quebec
H3B 1Z5 Canada


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- Flooding likely? Do the following:
Stay tuned to your local TV or radio station for updates.
If flash flooding is possible, move to higher ground immediately. Do not wait for instructions to move.
Flash floods can also occur in streams, drainage channels, canyons, and other areas known to flood suddenly. Also be aware that typical signs, such as rain clouds or heavy rain, do not always precede flash floods.
- Before you evacuate:
If you can do so safely, secure your home by moving your most essential items to an upper floor. Also bring outdoor furniture inside if time permits.
If instructed to do so by your local utility company, turn off utilities at their main source, using the appropriate switches or valves.
Disconnect electrical appliances. Be sure to use caution and never touch electrical equipment if you are wet or standing in water.
- When evacuating, remember the following:
Just six inches of moving water can cause you to loose your footing and fall. If you must walk through water, try to find water that is still. Also, use a stick to check the firmness of the ground in front of you.
Do not drive into flooded areas. If floodwaters rise around your car, abandon the vehicle if you can do so safely, and move to higher ground.
If you do find yourself out in your vehicle during a flood, Ready.gov offers the following "Driving Flood Facts":
Six inches of water will reach the underside of most passenger cars. This can cause your car to stall, or cause you to loose control of the vehicle.
It only takes one foot of water to float many vehicles.
Just two feet of rushing water can carry away most vehicles. That includes higher profile models, like sport utility vehicles (SUV's) and pick-up trucks.
Never attempt to drive through a flooded road. The depth of water is not always obvious or the roadbed may be washed out under the water, which can leave you trapped or stranded.
Never drive around a barricade. If you come upon a barricade, turn around and go the other way.
Avoid taking alternate routes or shortcuts, which may be blocked. Stick to designated evacuation routes.
Be especially cautious if you have to drive at night. It's much harder to detect flood dangers in the dark.
- After the flood, remember to:
- Download a PDF to print for reference in the event of a flood:
- Be Red Cross Ready: A Flood Safety Checklist
SOURCE: FEMA, Ready.gov,
Red Cross
Stay tuned to local alerts and warning systems. These are the best sources for information and informed advice as it becomes available.
We've said it before but it bears repeating: avoid moving water.
Stay away from damaged areas. Your local police, fire, or relief organization will ask for help if needed and will give instructions on where you should go to volunteer.
Stay off of the roads and out of the way so that emergency workers can assist people in flooded areas.
Play it safe. Additional flooding or flash floods can occur without much warning.
You should return to your home only when authorities indicate it is safe.
Never attempt to cross a closed road. Roads may still be closed due to damage or because they are covered by water.
If you can't avoid walking or driving in flooded areas, stay on firm ground. Moving water as little as six inches deep can sweep you off your feet. Also, use caution: standing water may be electrically charged from underground or downed power lines.
Continue to use caution even where floodwaters have receded. Roads can become weak and can potentially collapse under the weight of a car.
Stay out of any building that is surrounded by floodwaters.
Use extreme caution when entering buildings; there may be hidden damage in them, particularly in foundations.


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135 Chippewa, CRAWFORDVILLE, FL
$79,9003 Beds2 Baths
$79,9003 Beds2 Baths
135 Chippewa, CRAWFORDVILLE, FL 32327 - Very nice 3bed/2bath home on double lot. Over 1222 sq ft plus 20X15' Screened porch with nice bar. Also, 17'X20' carport & 10X12' metal shed. Back yard partially fenced!
Listing Courtesy of Shell Point Realty, Inc
"No one values your time more than all of us at Century 21 First Story Real Estate! You've picked us and we feel it is important to talk to you in person, not an email, not a text. There really are real humans on the other side of this device! We want to talk to you in a timely manner and we thank you for contacting us! We offer FREE home valuations and visits when you are selling! Leave us your information, then click "Request A Call" - We will call ASAP! Don' t sleep on it, sleep in it!"


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Anyone elses apps on IPHONE IPAD and desktop keep crashing?? I have not been able to use any of these now for several weeks and I am not getting any answers from Moenywiz support. Its all very frustrating and I will probably have to use the tool I use now for finance
Hi Karen
In the last 2-3 weeks I've had a few glitches such as not auto-refreshing but that was resolved quickly by Pawel and his team last week. Throughout that time, the apps seemed to continue working albeit using manual refresh. Have you lost connectivity to SyncBits perhaps?
I'm surprised to see your comment re not getting any answers from the folk at MoneyWiz. My experience has been the opposite; they've been quick to respond and then to chase down solutions with SaltEdge when needed. Personally, I'm impressed with their customer service, especially for the small cost of the App; but I know things can be different for each person. Good luck
Hello Karen,
First of all, I wanted to apologise for my late reply on the forums - when we receive lots of e-mails, they get the priority over forums but we try to be responsive all around.
I see that you have contacted us via e-mail and I see that Marina is in direct contact with you. I also see that we've not been able to resolve your issue entirely just yet and you're still experiencing some slower performance with MoneyWiz which we are working to address in the next update.
We did receive your last message and my colleague Marina will get back to you shortly. Apologies for the delay!
my desktop moneywiz premium does not sync from some days ago. I sent several automatic emails form the program but I did not receive any answer or solution. Sometimes appears "error 403"
We did receive your e-mail and I see that my colleague Marina has addressed this now. We'll be in touch with you via e-mail.


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By Kathie C. in Stockton, NY
As usual, my visit to Gay Mark was quick, comfortable, and efficient! ...more
By Harry W. in Cherry Creek, NY
Warren always goes out of his way to completely do the best at an honest price and a 5 star job
By Christine K. in Buffalo, NY
My daughters and I first started going to Gay Mark about 12 years ago. ...more
By Kathie C. in Stockton, NY
As usual, Warren provided dependable and timely service. I emailed for ...more
By James and Kim A. in Gerry, NY
great fast friendly service thank you
By Larry K. in Dewittville, NY
I had both cars in today, one for inspection, the other oil change and new rear shocks. Both cars were done in two hours. Very nice people to do business with.
By Pujan S. in Fredonia, NY
Warren was very courteous at Gay and Mark. Great service.
By Kim M. in Sinclairville, NY
Warren is pleasant to talk and efficient.
By Larry K. in Dewittville, NY
They finished the job quickly. I'm very satisfied with the service I receive.
By Neal R. in Cassadaga, NY
Fast, efficient and friendly service. Great to have this locally for me.
By Karl L. in Cassadaga, NY
Stopped in Monday A.M. no appointment for vehicle inspection, over due, they did it right now. There and back home in 45 minutes. Thanks Warren and staff.
By Larry K. in Dewittville, NY
I took two cars in this morning for new tires and an oil change. I was in and out in less than two hours.
By Edward W. in Lily Dale, NY
it's a smooth, efficient and very accommodating experience - I'm gaining what could only be called confidence in Gay Mark tire and Wheel.
By David D. in South Dayton, NY
Have always been pleased with anything I needed done to my vehicle.
By Ray T. in Lily Dale, NY
As always, the vehicle was serviced in a timely fashion , and the job was done correctly and thoroughly. We will continue to service all of our vehicles at this garage!


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Center for Data-Driven Transportation Research
The Next Generation of Mobility
The mission of the Center for Data-Driven Transportation Research is to harness the power of big data to help develop the next generation of mobility, from driverless and autonomous vehicles to integrated multi-modal transportation systems. The center is partially funded by the $100 million Data Science Initiative, which, among other efforts, provides faculty research grants for projects likely to garner significant investment from industry or government.
Center for Data-Intensive Learning Analytics Research
Improving education through data
The Center for Data-Intensive Learning Analytics Research helps U-M faculty take advantage of the trove of student data collected by the University over the years to improve educational practices and student outcomes, and is partially funded by the $100 million Data Science Initiative.
Center for Data-Intensive Health Science Research
Advancing the spectrum of biomedical research
The Center for Data-Intensive Health Science Research aims to enhance U-M biomedical researchers' ability embrace the opportunities and challenges brought about by advances in data science. The center will catalyze the development of theories and innovative methodologies in data science, and their application to the entire spectrum of biomedical science, from basic research to translation research, to clinical applications, with the ultimate goal of using data science to improve the health of our society.
Center for Data-Intensive Social Science Research
Leading the evolution of social research
The data science revolution is bringing unprecedented opportunities to social science research. Never before have we had such enormity and variety of data, from endless social media streams to every survey imaginable, from outputs of every conceivable sensor and wireless device to massive consumer databases. We are seeing data in every form, every level of granularity and quality. Social scientists' newest challenge is to generate insight from the data for the political, economic and social wellbeing of individuals and our society.
Research Highlights
Learn about graduate programs that will prepare you for success in computationally intensive fields — pizza and pop provided The Ph.D. in Scientific Computing is open to all Ph.D. students who will make…
Five research teams from the University of Michigan and Shanghai Jiao Tong University in China are sharing $1 million to study data science and its impact on air quality, galaxy…
The Amazon Research Awards (ARA) program offers awards of up to $80,000 in cash and $20,000 in AWS promotional credits to faculty members at academic institutions in North America and…
Professor Liza Levina has been selected to present an Institute of Mathematical Statistics (IMS) Medallion Lecture at the 2019 Joint Statistical Meeting (JSM). Each year eight Medallion Lecturers are chosen from…


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CALL ATTORNEY KEITH F. CARR for a no obligation, free confidential initial consultation to discuss your financial situation:
San Jose-Sunnyvale: (408) 673-1428
San Francisco: (415) 935-3744
We charge an affordable fixed fee for Chapter 7 Bankruptcy. Whether you are facing lawsuits, debt collection calls, wage garnishment, foreclosure, give us a call.
When you call we will discuss your financial situation and determine your Bankruptcy Fee. Attorney Keith F. Carr will not take short cuts with your case. Your Chapter 7 fixed fee includes full representation in Chapter 7, including preparation of Chapter 7 petition, legal counseling on all matters in the Chapter 7 Bankruptcy, attorney's appearance at the Meeting of Creditors with the debtor.
To determine if you qualify for Chapter 7 bankruptcy and obtain an in-depth analysis visit the Bankruptcy Evaluation and Analysis Form. Your complete bankruptcy analysis by Attorney Keith F. Carr is free (a $50.00 value).
In addition to the fixed fee for Chapter 7 Bankruptcy, you must pay for the Court Filing Fee for Chapter 7, which is $335.00. There are other costs to filing a Chapter 7 Bankruptcy that you should be aware of - Credit Counseling Fee and Debtor's Education Fee.
Attorney Keith F. Carr has over 25 years experience in Bankruptcy law practice. Read more about How our clients rate us.
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Election season is gearing up for most towns in New Jersey. Besides all of the promises, stances, and handshakes, there comes the line that "you matter". Not gonna lie here – you DO! Your input counts a lot more than you think.
Where does your input count most? When they hire us, the Superintendents. Essentially, we are a reflection of the Board. The majority of folks on the board choose the Superintendent based on our beliefs, what we've done, and what we plan to do. Since you elect the board members, and that's a reflection of your input, you are putting a whole lot of trust in whom they pick to lead the district.
When interviews roll around for Superintendent positions, there are scads of questions asked in interviews. Some of the best questions come from community surveys. More and more, boards are are posting feedback surveys on website that address a myriad of questions ranging from what background should the Superintedent have to what problems do you foresee in the future. Decent surveys will throw questions up that have locals identify the positives of the community. Districts should also have questions that reflect the mission statement and vision. Hopefully, the district will avoid the personality trait question. The characteristics question is always a "gotcha", and often elicits bad vibes based on past experiences. It could bring some good stuff out, but chances are it won't.
So before you hang up on that election call, remember… You really do matter.


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Customer Reviews Of:
DownTown Mattress Pad - Full, Merino Wool Fill, Anchor Bands
Closeouts. Naturally lofty, soft and moisture absorbent, the merino wool filling of DownTown's lofty Full mattress pad protects as it comforts with soft jersey cotton.
Average Rating based on 9 reviews 4.222222 0 5
Verified Buyer Reviewed by C from ringoes NJ on Tuesday, May 12, 2015ive never seen a matress cover like tihis one. Its stuffed with a thick layer of wool that turns my firm flat matress into a plush bed. the only negitive is it adds warmth in summer. will be wonderful in the winter time. This matress pad is so nice that Im thinking about getting a second for a blanet. It also would make a great floor covering for a baby to play on.
Reviewed by Steven from Georgia on Saturday, November 29, 2014I guess I'm one of the fortunate buyers that received one that doesn't smell like animal and I have a sensitive nose. However, it is a bit small for my queen mattress, but no big deal...I used bungee cords to secure the elastic straps on the corners underneath the mattress (criss-crossed two cords).
It is very comfortable, warm in winter and cool in summer.
Reviewed by Anonymous from colorado on Monday, November 17, 2014If you don't like the smell of animals, then don't buy this -- it definitely has a sheep/lanolin smell.
Also, the two I bought ran small -- I purchased both a queen and a full, and the queen fits our daughter's full-size bed (which means now I don't have anything for my queen).
It does feel soft and comfortable, however.
Verified Buyer Reviewed by Serious Seattle Shopper from seattle on Thursday, October 16, 2014This mattress pad is a bit over .5 inches of padding and is comfortable. It is not a major difference but it is noticable. The price is good for the all cotton & merino wool materials and the wool should help with temperature regulation/any sweating. It DOES come with a strange (as 1reviewer said) almost gasoline scent. It really does. I tossed it on low in the dryer with 2 scented dryer sheets and lightly sprayed vinegar on both sides before putting it in. It did not shrink and helped on the odor but did not eliminate it completely. This would be the only reason to consider returning. Once it is covered with a mattress pad/protector and then sheet it is more subtle & becomes a bit of animal smell instead. Otherwise, it is great for those wanting a wool mattress pad & no polyester. Most wool pads are no less than $150 & that would usually be a twin size so this is a good price.
Reviewed by Randy from Georgia on Wednesday, November 27, 2013I have another wool mattress topper that is made of just the fur. I got this to put under it to add some extra cushion. This is nice and soft and has a good loft to it. Helps keep the bed warmer in cold weather and if its like my other one it should help keep it cool in the summer. This seems like it will breath really well too.
Verified Buyer Reviewed by warm sleeper from Sonoma County, CA on Monday, January 28, 2013This is a fantastic mattress pad. The first night I had it on my bed, I slept long and never woke up with the middle of the night chill that I had the previous week or so. I don't heat the house during the night, and my bedroom gets into the 40's in the coldest nights of our admittedly mild winter.
Will be interesting to see how it fares in the summer. But I wear wool year round, so I bet it's going to be wonderful!
Best buy in ages. Thanks !!
Verified Buyer Reviewed by Twirp from Northern Arkansas on Thursday, January 24, 2013The only drawback for me is drycleaning. Yuk! However the pro's outdo the con.
Verified Buyer Reviewed by Judy from Downingtown, PA on Wednesday, December 12, 2012This pad replaces a "memory foam" pad that I had purchased (also from STP) a year ago. Both my husband and I have had back problems in the past, so a comfortable bed is important to us--not too hard, not too soft. Unfortunately, the memory foam "remembered" the center fold from its original packaging, so we slept with a big bump between us! This new pad is very flat on the bed, and it's cover is a very soft cotton knit. It feels perfect--just the right amount of support, soft yet firm. The only thing that would improve it would be how it attaches to the mattress. The elastic is wide and seems strong, but it doesn't reach very far under the mattress. Would be better if the jersey cover reached all the way under. But still, it's very very nice.
Verified Buyer Reviewed by Natural product enthusiast from New York on Tuesday, October 9, 2012I used a similar product when I lived in Germany and loved it. I was happy to see that I could find one in the United States. In fact, I ended up buying two and may buy a twin size for my daughter's bed.
- Best Uses: Mattress Cover For Winter
- Pros: Soft warm thick


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General Science Tutors in Karāchi, Pakistan
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Postgraduate Institute of MedicalEducation and Research
Postgraduate Institute of MedicalEducation and Research
Vaishnavi C.,Jawaharlal Institute of Postgraduate Medical Education & Research |
Singh M.,Jawaharlal Institute of Postgraduate Medical Education & Research |
Mahmood S.,Postgraduate Institute of MedicalEducation and Research |
Kochhar R.,Jawaharlal Institute of Postgraduate Medical Education & Research
Journal of Medical Microbiology | Year: 2015
Clostridium difficile infection (CDI) leads to considerable morbidity and mortality among hospitalized patients. Faecal specimens from 1110 hospitalized patients suspected for CDI were cultured for isolation of C. difficile and characterization of virulence genes. PCR was carried out for toxigenic genes tcdA, tcdB, cdtA and cdtB and PCR-RFLP for fliC and slpA genes. Of 174 (15.7 %) C. difficile isolates, 121 (69.5 %) were toxigenic, amongst which 68 (56.2 %) also had both tcdA and tcdB genes. The remaining 53 (43.8 %) of the isolates also had at least one of the toxin genes. Binary toxin genes (cdtA and cdtB) with only one of the two components were present in 16 (9.2 %) of the 174 isolates. The other virulence genes – fliC and slpA – were present in 100 % of the isolates. The most frequent PCR-RFLP type of fliC gene was type I (n5101), followed by type VII (n549) and type III (n524). The slpA gene presented with three combinations of patterns. Characterization of virulence genes in C. difficile isolates is of extreme importance for epidemiological surveillance and control of outbreaks owing to the capacity of this bacterium to adapt to new environmental circumstances, leading to the emergence of new epidemic strains. © 2015 The Authors.
Dutta P.,Postgraduate Institute of MedicalEducation and Research |
Bhansali A.,Postgraduate Institute of MedicalEducation and Research |
Walia R.,Postgraduate Institute of MedicalEducation and Research |
Khandelwal N.,Postgraduate Institute of MedicalEducation and Research |
And 2 more authors.
Indian Journal of Medical Research | Year: 2012
Background & objectives: Hyperthyroidism is associated with increased food intake, energy expenditure and altered body composition. This study was aimed to evaluate the role of adipocytokines in weight homeostasis in patients with hyperthyroidism. Methods: Patients (n=27, 11men) with hyperthyroidism (20 Graves' disease, 7 toxic multinodular goiter) with mean age of 31.3±4.2 yr and 28 healthy age and body mass index (BMI) matched controls were studied. They underwent assessment of lean body mass (LBM) and total body fat (TBF) by dual energy X-ray absorptiometer (DXA) and blood sample was taken in the fasting state for measurement of leptin, adiponectin, ghrelin, insulin, glucose and lipids. Patients were re-evaluated after 3 months of treatment as by that time all of them achieved euthyroid state with carbimazole therapy. Results: The LBM was higher (P<0.001) in healthy controls as compared to hyperthyroid patients even after adjustment for body weight (BW), whereas total body fat was comparable between the two groups. Serum leptin levels were higher in patients with hyperthyroidism than controls (22.3±3.7 and 4.1±0.34 ng/ml, P<0.001), whereas adiponectin levels were comparable. Plasma acylated ghrelin was higher in patients than in controls (209.8±13.3 vs 106.2±8.2 pg/ml, P<0.05). Achievement of euthyroidism was associated with significant weight gain (P<0.001) and significant increase in lean body mass (P<0.001). The total body fat also increased but insignificantly from 18.4±1.8 to 19.9±1.8 kg. There was significant decrease (P<0.05) in serum leptin and acylated ghrelin but adiponectin levels remained unaltered after treatment. Serum leptin positively correlated with TBF and this correlation persisted even after adjustment for BW, BMI, gender and age (r=0.62, P=0.001). However, serum leptin and acylated ghrelin did not correlate with the presence or absence of hyperphagia. Interpretation & conclusion: Patients with hyperthyroidism predominantly had decreased lean body mass which increased after achievement of euthyroidism with carbimazole. The hyperphagia and the alterations in weight homeostasis associated with hyperthyroidism were independent of circulating leptin and ghrelin levels.


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ACTThe ACT requires a different kind of discipline than the SAT, and can be a beneficial experience for students who are intimidated by the SAT hardest questions. It is a test that rewards patient, thorough test takers - those who excel at one task at a time and push themselves consistently for the duration of a task. To parents and students who grew up in the northeast, the ACT feels as though it is the "other college admissions test." Yet in other parts of the country, particularly the Midwest and the South, it is the test most college-bound students prefer. A competitive score on the ACT opens just as many doors as a great SAT score. Here's how we approach the ACT:
To find out more about our ACT prep, please contact us. We'd be glad to share more. ← back to tests


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Filing an injury claim in Helston?
If you're filing an injury claim in Helston and want a lawyer then you would do well to call Accident Advice Helpline. Helston is a civil parish and town that is situated in the Lizard Peninsula, to the northern end, in Cornwall, England, United Kingdom. It lies 14.5 km (9 miles) to the southwest of Falmouth and around 19 km (12 miles) to the east of Penzance. After the town of Marazion in Cornwall, it is the 2nd oldest town in Cornwall.
Compensation for an injury claim?
If you have been hurt in Helston, then you could get compensated for these injuries under the following conditions.
- You were injured in Helston because of the fault of some other person
- Because of the injuries that you got, you had to seek medical treatment
- You got these injuries in Helston, within the last 3 years
As such, in the above circumstances, it is very likely that you could be compensated for the injuries. But as this is a legal process, it is advisable that you take the services of an injury claim in Helston.
Lawyer for your injury claim
Getting a lawyer to help you file a claim for your injuries is easy to do, just make a call to Accident Advice Helpline. This law firm has helped people with injuries in Helston and all over the UK, file claims and seek compensation.
You can talk to the friendly advisors without having to pay anything as if you call from a landline, your call is free. These advisors will check and tell you if your claim is a valid one and they will also guide you and let you know about the claims process.
Great benefits of calling Accident Advice Helpline
- You get to call the law firm whenever you choose as they have a 24/7 Helpline
- Our firm has in-house experts who will give you the best legal advice on how to get compensated for your injuries
- You are under no obligation whatsoever to take the services of the law firm after you have got the advice that you are seeking
Hurt in Helston?
Call up Accident Advice Helpline and have a word with our in-house experts and you will get help with injury claim in Helston by calling the number 0800 689 0500 or from a mobile phone you can call the number 0333 500 0993.
Date Published: 25th September 2013
Author: David Brown


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One of the most exciting things to happen at Beachglow Music Festival was the fact that I finally got to see Gazzo perform live. I've been following his music for many years. I follow him on social media. He seems like a standup dude. After meeting him, he is a standup dude. What surprised me most about his set is he didn't end with a big track, but he ended with a live set as you can see above. That changed everything for me as going into the interview, I needed to know more. He discussed his love for music and how he wants to transcend the boundaries of DJ shows and Live shows. Essentially doing a bit of both because he has an affection for both playing live and DJing. How he explains it is wild and only excites me for the future. We discuss a bit more, but I will leave that to the interview below. It was such a great honor to meet someone that I been wanting to meet for a while and for him to blow my mind like that.
You are here: Home / News / EDM News / Interviews / [EDM Assassin Exclusive] Gazzo Interview


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WEDNESDAY, Aug. 12, 2015 (HealthDay News) -- Lyme disease may be grossly under-reported in the United States. Government researchers say the tick-borne infection affects about 10 times as many Americans as previously indicated by confirmed case reports.
About 329,000 cases of Lyme disease occur every year, researchers from the U.S. Centers for Disease Control and Prevention found in their analysis of a nationwide health insurance claims database for 2005 through 2010.
Also read: Army Sgt. Bowe Bergdahl, held captive for five years, pleads guilty in connection with disappearance
Read more


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Concerned by the growing political and economic crisis that has rocked the country for the past few months, political economist Moeletsi Mbeki warns President Zuma and his government to fix the economy or face an unexpected war.
Addressing an audience during the launch of his book 'A Manifesto for Social Change: How to Save South Africa', Mbeki warns that there was a low-intensity "hidden" civil war in South Africa, which could be worsened if the country failed to move to full industrialization to increase the economy.
Also See: SA Economy Is Drowning Yet DCS Awarded A R370 Million Tender Whereas It Had R16m In Its Budget
He further pointed out that the current internal violence among ANC supporters in KwaZulu-Natal was a sign of war and that should the government fail to adhere to this call and engage in "a very radical restructuring of our society", which would industrialize the country and lead to massive employment, worse situations will be lying ahead.
"South Africa has what we call the hidden civil war. Part of it is becoming visible like we are seeing within the ANC in KZN.
"This is a very troubling situation for the future of the country," he said.
When asked when he thought the hidden war would come to the surface, Mbeki said: "What we are saying in this book is that an explosion of this nature is inevitable in South Africa."
According to him, the country had the highest murder rate after Syria, which was at full-blown civil war. He went on to say that the cause of the trouble in the country was that more than 50% of young people were unemployed and either depended on their employed family members or government grants.
"We have on average 18 000 murders a year in South Africa. We are not at war, but we have rate of violent death next Syria, and Syria is at war. Unlike Syria, ours happens year in and year out. The civil war in Syria will come to an end and then those violent deaths would stop."
He said government leaders overtaxed the private sector in order to pay themselves and their support staff, public servants, at a rate of more than 20 times the salaries earned by similar staff in the private sector.
He also said President Zuma's salary was higher than those of the prime minister of England and chancellor of Germany.
Also See: A Look At How Much Our Beloved SA MPs Earn
According to him, SA's GDP and that England and Germany are in no way related yet the president and the rest of the public sector still earn higher than those in these countries.
He summed all up by adding that political elites use power to enrich themselves and its support systems. This is one of the sources of conflict in South Africa Mbeki warns.


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Visit Beach City - Best of Beach City
Beach City is a village in Stark County, Ohio, United States. The population was 1,033 at the 2010 census. It is part of the Canton-Massillon, OH Metropolitan Statistical Area.Wikipedia
If you are looking for travel information of Beach City in United States, you've come to the right place. This city is located in the close proximity of a major city Pittsburgh, United States. So, ideally any vacation planner would recommend you to visit Pittsburgh for its bountiful attractions like Pnc Park, Duquesne Incline, Phipps Conservatory on your trip to Beach City. Also, to reach Beach City, you'll have to take a flight to Pittsburgh; so its not really a detour. And even if it is, the city is worth paying at least a quick visit. A holiday in Beach City can generally be of 1-2 days.
Don't just take a trip, let the trip take you! Have a enjoyable time at Beach City.
Explore the best travel planner for your visit to Beach City and create a flawless plan in few simple steps!


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Samsung has blocked rooting the international version of the galaxy S3 GT-I9300 by using SafeRoot method, which was completely safe, easy and it doesn't void the warranty of the phone nor trip flash (binary) counter.
I have found a way to make "SafeRoot" root the galaxy S3 GT-I9300 on the latest android 4.3 jelly bean like any other devices.
Requirements :
- I9300_Root_Kernel file
- I9300_MK6_Kernel file
- Odin3
- Installed Samsung Kies or Samsung mobile USB driver
- Saferoot file
Instructions :
- All the process WON'T wipe your data, but back it up just incase this process corrupt your data.
- Flash Root_Kernel.tar.md5 file by odin3 in PDA or AP section.
- Make sure Re-Partition is NOT selected.
- Root your device using SafeRoot method by following this guide : [No Warranty Void] Safe Root Android 4.3 for Galaxy S3/S4 Note 2
- Flash back the current kernel of your firmware MK6 until Samsung update it by Odin3
Congratulation, your galaxy S3 GT-I9300 is rooted on the latest version of Android 4.3 jelly bean without tripping flash (binary) counter.
YT video link : http://www.youtube.com/watch?v=3gYjoW22h7c
- Download and install manually busybox if the tool is failed to install it.
- Use this guide at your own risk
- This process and kernel files ONLY for the international version GT-I9300 and ONLY for Android 4.3 jelly bean.
- Normally this process will continue to work until Samsung starts to push Android 4.4 kitkat to the S3 (DON'T use it on 4.4 kitkat, it will brick your device).
- You will not be able to receive OTA update, but you can update your device at any time by Kies or Odin3.
- This process is tested by me and worked on all the latest Android 4.3 jelly bean firmwares.
- To unroot your device –> Open SuperSU app / Settings / Full UnRoot.
Downloads :