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Category: Travel & Leisure
Posted Feb 9, 2017 02:33 (GMT +7)
Tourico Holidays Joins Hotelbeds Group1
Hotelbeds Group, a global bedbank and business-to-business provider of services to the travel industry, has announced today plans for Tourico Holidays to merge with its Bedbank business unit.
This Smart News Release features multimedia. View the full release here: http://www.businesswire.com/news/home/20170207006641/en/
(From right to left) Joan Vilà, Executive Chairman of Hotelbeds Group and Uri Argov, CEO of Tourico Holidays (Photo: Business Wire)
Commenting on the news, Joan Vilà, Executive Chairman of Hotelbeds Group said: "With the backing of Cinven and CPPIB we are entering the next phase of our development since becoming an independent company back in September.
"Therefore it gives me great pleasure to announce that Tourico Holidays will join Hotelbeds Group. Tourico Holidays has a well-deserved reputation for excellence and innovation that I have respected for many years. I look forward to working with its experienced leadership team.
"The proposed deal will enable us to enhance our footprint, especially in Tourico Holidays' home market of North America whilst they will benefit from belonging to Hotelbeds Group´s global network. Together we will combine our best in class technology and distribution expertise for the benefit of both our hotel partners and clients.
"For the time being, both businesses will continue as usual, focusing on our top priority: providing the best possible service to our hotel partners and clients."
Tourico Holidays' CEO, Uri Argov added: "We´re very excited about what this deal can mean to the B2B travel industry. Tourico Holidays' management team looks forward to bringing together these two great businesses in order to better serve our combined supplier and client base. At a cultural level, this deal is strong because our two organisations are both entrepreneurial, dynamic and high energy – and just like Hotelbeds Group, we´re passionate about what we do and focus hard on execution."
Tourico Holidays will continue to operate as an independent business while a long term strategy is developed to find the most appropriate way to combine the businesses.
The transaction is subject to customary regulatory and anti-trust approvals.
About Hotelbeds Group:
Hotelbeds Group is the world's number one bedbank and a business-to-business provider of services to the global travel industry.
Operating mainly under the Hotelbeds and Bedsonline brands, the company connects, 35,000 travel intermediaries across more than 120 source markets globally with travel providers in over 180 countries representing more than 120,000 hotels, 20,000 transfer routes and 12,000 activities.
In September 2016 the company became independent under the ownership of Cinven and Canada Pension Plan Investment Board (CPPIB). The company is headquartered in Palma, Spain and has 6,150 employees working across 150 offices globally. In the financial calendar year of 2014 / 15 Hotelbeds Group sold around 26 million room nights and achieved a Total Transaction Value (TTV) of €3.8 billion.
About Tourico Holidays:
Tourico Holidays is a leading global travel distribution company that contracts directly with travel providers, such as hotels, flights, cruise lines, attractions, car rentals, vacation homes and more. The company works on a high volume, wholesale model to broker this inventory to over 4,900 clients in 100 countries using proprietary technology.
1 This includes the top holding company of the Tourico Group and indirectly all its entities, including its holding subsidiaries, Tourico Holidays, Inc., Travel Holdings, Inc. and Tourico Holidays Spain, S.L., and the technology development Israeli subsidiary, T.G.S. Israel Development Ltd. The deal will be legally structured via the merger of the top holding company of Tourico Group (´Travel Holdings Parent Corporation´) and Hotelbeds US Holdco, Inc., Hotelbeds Group Holding´s legal entity in the United States. The merged entity will be 100% owned by Hotelbeds Group.
View source version on businesswire.com: http://www.businesswire.com/news/home/20170207006641/en/
Hotelbeds Group
Roman Townsend, +34 619 988 580
Head of Media Communications, Social Media & Corporate Affairs
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◎译 名 邪恶之物
◎片 名 Evil Things
◎年 代 2009
◎国 家 美国
◎类 别 恐怖
◎语 言 英语
◎IMDB评分 5.3/10 (73 votes)
◎文件格式 XviD + AC3
◎视频尺寸 720 × 400
◎文件大小 1CD 94 x 15MB
◎片 长 87 mins
◎导 演 Dominic Perez
◎主 演
Gail Cadden ... Aunt Gail
Laurel Casillo ... Cassy Crawford
Morgan Hooper ... Mark Schaefer
Ryan Maslyn ... Leo Pugliese
Elyssa Mersdorf ... Miriam Dearing
Cynthia Shaw ... Film Extra
Torrey Weiss ... Tanya Kochen
It`s Miriam`s 21st Birthday. As a birthday gift, Miriam`s aunt Gail has decided to lend Miriam her beautiful country house for an entire weekend. Aunt Gail`s country house is amazing. It`s a four bedroom house surrounded by breathtaking mountains and miles and miles of woods. Miriam invites her young college friends Cassy, Mark, Tanya and Leo to join her at the country house for what looks to be the most amazing weekend ever. Of course they all jump at the chance to spend a free weekend in the country, in the middle of nowhere. Miriam`s friends are totally in the mood for a big time party weekend. They`re also anxious to escape the dark and gloomy concrete jungle known as Manhattan. Miriam, Cassy and Tanya bring the food. Mark brings the beer and Leo, the aspiring filmmaker, brings his new video camera. Leo hopes to produce a short movie by documenting every amazing moment of this weekend getaway.

subset: commoncrawl


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Tax refunds, according to Forbes.com, this year, are mostly likely to go towards debt repayment, savings or wait for it… plastic surgery. Figuring out how best to use your windfall this tax season can be daunting, especially for the bourgoning millenial generation. The world is seemingly theirs for the taking, should they be so inclined.
The other day I sat down with my good friend and financial advisor, David Benjamin of Bethesda, Maryland to discuss some of the most common financial concerns of the millennial generation.
So, unlike Gen-exers who, myself included, never cared or worried to much about much of anything, The millennial generation, having come of age during difficult financial times, seems much more tuned in worried about the future.
What would you say are the biggest financial concerns of your millennial clients?
Today's rising generation struggles with finding a balance between saving for the future and living in the now. For example, I hear this question all the time;
"My parents always tell me to start saving for retirement early. I can barely afford to pay rent, service my student loan debt, and maybe go to the movies. Should I be saving more?"
I tell them this; be sure to contribute up to the match in your 401k, pay down credit card debt while you build your cash reserve, and pay the minimum on your student loans.
Obviously this is not the recipe for everybody, it's a pretty good guideline. I think the hardest part is accepting that your student loans will be with you for the next 20-30 years.
The second question I hear often is regarding investing.
Something like;
"My grandparents left me a little money that I will probably use in the next few years towards, wedding or home down payment. How can I invest this money so that it grows before I need to spend it?
You should look at an FDIC insured cash account or CD. Typically online banks will have the best rates. I know this isn't very sexy, but if you were to buy a stock or fund that lost money and you were counting on that cash for an important purchase you could be disappointed if the investment was down and you took a loss.
Any general advice to help millennial get ahead?
Cut your overhead. It seems like younger people pick the neighborhood they want to live in and then "compromise" on getting an apartment that didn't have granite countertops. But often even the cheapest apartment in that trendy neighborhood is out of their budget. I also see recent grads living at home with their folks for a little while after college, but driving a Mercedes or dining out a lot. Wasn't the purpose of living at home to save up some money? Just because you made a sacrifice to live at home doesn't mean you deserve to splurge.
What's the best thing you think millenials have going for them financially?
The are very savvy consumers. They grew up with the Internet at their fingertips,so doing their homework on purchases comes quite naturally. Furthermore they evaluate the value they receive on subscription services. If they aren't watching a lot of tv, they cut the cord. If they aren't using the gym, they quit and reallocate those funds towards something they will get a return on their investment from.
When investing, what should they be considerate of?
Frankly, for the past decade the markets have been extremely volatile. If you assume the average person starts to "tune in" at age 18, many Millenials have been hearing about the markets for about the last ten years. With the economy sluggish and markets wild during their entire adulthood, there becomes a tendency to be more conservative. If things improve over time, I think that bias towards conservative investments could hurt their investment returns over the long run.
Perhaps the best solution would be to embrace moderation this tax season. Instead of throwing all your chips in one basket, why not divide your refund into thirds. By contributing equal amounts to the three most popular areas; pay off debt and repair your credit contribute to investment portfolio and for the love of Instagram, get some plastic surgery.
No matter what, remember that all the money and beauty in the world does not, I am told, buy happiness. Alas, that is something we must find on our own.
May happiness be your companion always my friends. Until next time, be well!


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The most delightful winter cushion cover which is super soft to touch, made from a velvet polyester fabric. A photographic image of the cutest Snowman stood there in his bright red knitted scarf, black buttons down the front, brown fur hat& a carrot for his nose. The reverse of the cushion is a plain natural fabric with a zip fastening.
This would look super cute in someones home this winter. Maybe have to put it away come spring otherwise it may make you feel a bit cold.
Checkout our full range of winter, Christmas cushions along with our winter, Christmas bedding.
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Material: 100% Polyester
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We are a plant and forest biotechnology company providing products and technologies to improve the productivity and performance properties of plants and wood for forest owners and fiber related industries. Our vision is to be one of the world-leading providers of new technologies based on biological knowledge for tree plant producers and forest owners globally.
Kategorier: Biotech


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You have to get a good choice with what you can do the best? ask about your qualities? the duration? the job opportunities? i guess this is the best way to do so
by ViralWhisper6 years ago
It didn't really surprised me why the U.S. was not even in the Top 10 for the best educational system in the world according to the most recent survey. There's a real problem in the system of education in the U.S. and...
by Grace Marguerite Williams4 years ago
A cousin of mine has a 30 year old son who will not work. He has a Masters in Medieval History from a renowned university. He obtained that degree at 25 years of age. He has looked...
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Duncan on All-Defensive team for record 14th timeMay 13, 2013 Updated: May 14, 2013 9:14am
Photo: Jeff Chiu, AP
At age 37, Spurs captain Tim Duncan finished third in the NBA in blocked shots (2.65 per game) and fifth in defensive rebounds (8.1) in an average of just 30.1 minutes.
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- Brigitte Mathiak, Andreas Kupfer, Carolina Rio Bartulos, Tatjana Scope, Johann Weiland, Silke Eckstein
- Seventh IEEE International Conference on Data…
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Finding out which genes are expressed in which circumstances is one of the most common tasks in text mining for bioinformatics. But usually the derived data comes from the abstract or other describing texts in the literature. In the age of modern high-throughput microarray analysis, however, there is too much data to be described textual; instead this data… (More)
- Brigitte Mathiak, Andreas Kupfer, Tatjana Scope, Britta Störmann, Silke Eckstein
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The aim of literature retrieval is to find significant papers on a given topic. In previous publications, we examined the use of choosing these papers based on the pictures they include. To refine this approach we seek to employ picture classification to further narrow down the number of interesting pictures presented. This can be useful, for example, when… (More)
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Annual Book Fair to be held April 7, 8, 9th 2017. FOR MORE INFORMATION CLICK ON THE BOOK FAIR LINK ABOVE!!
9/6/16 Keokuk Library, Lower Level
Thea Dennis, Fulbright Scholar
Dev K. Carry-In Salad Dinner
10/4/16 Keokuk Library, LL
Public Policy Issues – How Do We Cast our Vote Based on the Issues? – Deb Hedger – Southeastern Community College Economics Instructor
Barb C.
11/1/16 Grand Theater
Tour of the Grand Theater Diane S.
12/6/16 Keokuk Library, LL
Annual Book Discussion Members bring holiday treats to share.
2/7/17 New Bethel Church
Speaker – Freedom Rider from Fairfield Dev K.
Dinner made by Women of Bethel Church – cost – approx $10 – contact Dianne Stanley at 319-524-2086 to make reservations
Dinner at 6:00 PM at New Bethel Church 1217 Morgan St Keokuk Meeting at 7:00 PM
3/7/17 Keokuk Library Lower Level Women in History month
Sandy S.
4/4/17 Keokuk Library LL
Dev will share photos and stories from trip to Cuba. Dev K.
5/6/17 Member's home?
Possible Exchange Student or Sister Cities Carry in Brunch
2016-17 Keokuk Branch Officers
• President – Dev Kiedaisch
• Vice President Programs – Dianne Stanley
• Vice President Membership – Barb Casady
• Secretary – Sue Prochazka
• Treasurer – Janet Fife – LaFrenz
• Fundraising/Book Fair – Sandy Seabold
Additional Events
• Friday, September 9 – 11:00 to 1:00 – Southeastern Community College – "Welcome Back Student Lunch" – AAUW will have a table to promote AAUW, register voters and have absentee ballots.
• Monday, September 19 – Iowa Supreme Court @ the Grand Theater. 8:00 – 5:00 – sponsored by AAUW – Diane Stanley will coordinate.
• Possible Candidate Forum – possible co-host with Chamber of Commerce – Diane Stanley will coordinate.
For Information on the benefits of AAUW membership click on the Benefits of Membership link under AAUW on the right side of this page.
American Association of University Women (AAUW) is a nationwide network of more than 170,000 members and supporters 1,000 branches, and 800 college/university institution partners.
For 130 years, AAUW members have examined and taken positions on the fundamental issues of the day — educational, social, economic, and political. Our commitment to our mission is reflected in all aspects of our work.
AAUW's Mission
AAUW advances equity for women and girls through advocacy, education, philanthropy, and research.
AAUW's Value Promise
By joining AAUW, you belong to a community that breaks through educational and economic barriers so that all women and girls have a fair chance.


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This is a photo of one of my pieces, currently untitled. It is 8.5 x 11. I made it as one of my journal pages in March of this year. We made a page each month, but we only had to choose five to submit to the exhibit. This is one that I did not include for the exhibit. I used some of my photographs to experiment in layering/transparency using organza as well as vellum. This photo was taken before I put the edging around it.
I was fortunate to attend the Houston International Quilt show for the first time this year. I got to see and be inspired by this year's journal pages exhibit. It gave me a chance to read the other artists' statements and have a more intimate viewing of such personal/creative/experimental works. I attended the Studio Art Quilt/Journal Quilt reception as well and was able to pick up my copy of Creative Quilting: The Journal Quilt Project in person. Many thanks to Karey Bresenhan for creating this project and hosting the reception.


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Don't want to head out? Check out curated comedy videos and recommendations on what to watch!Stay in
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Sketching & Painting Workshop
Delhi winters call for not only sipping wine, but also painting it!
Get artsy and paint your own bottle of wine and fruits!
When you need a break, Bronx Cafe shall feed you some delicious starters and mocktails!
All art supplies will be provided! You only need some passion for Art to get the painting done; we will give you step-by-step instructions to get you there!
Explore your creativity with The Growing Seed and take your Art home.
Ticket price includes Art Materials, Food & Drinks
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Gold imports by India, the world\'s largest consumer, may drop as much as 50 per cent in December after a plunge in the nation\'s currency to a record low drove up prices, according to the Bombay Bullion Association. Imports may total 35 to 40 metric tonnes this month, compared with 70 to 75 tonnes a year earlier as demand remains \"dull\", Prithviraj Kothari, president of the association, said yesterday by phone from Mumbai. Purchases this year may decline as much as 11 per cent to 850 tonnes from 958 tonnes a year earlier, he said. Reduced purchases by India may weaken gold prices, which have declined 17 per cent since reaching a record of $1,921.15 (Dh7,056) an ounce on September 6 on growing optimism over an economic recovery in the US and gains in dollar. Gold typically moves inversely to the dollar. \"Inflation is too high and buying is not very aggressive,\" Kothari said. \"Only a decline to the Rs25,000 (Dh1,731) level will spur some buying interest.\" Gold for delivery in February on the Multi Commodity Exchange of India Ltd. jumped to a record Rs29,247 per 10gm on December 7. Futures, which has gained 33 per cent this year, traded at Rs27,664 at 3:02pm in Mumbai yesterday. The rupee is Asia\'s worst performer this year, reaching a record low of Rs54.305 a dollar on December 15, even as inflation remained above nine per cent for the 12th month in November.
GMT 19:31 2017 Wednesday ,18 OctoberAsia rally ticks along as Tokyo extends surge to 12th day
GMT 16:08 2017 Saturday ,14 OctoberUS stocks rise on strong retail sales; Europe mixed
GMT 04:42 2017 Saturday ,14 OctoberEgyptian Bourse gains EGP 2.6 bn
GMT 04:32 2017 Saturday ,14 OctoberUS stocks rise on strong retail sales; Europe mixed
GMT 13:18 2017 Friday ,13 OctoberIndia's TCS profits fall amid weak growth in retail, banking
GMT 20:52 2017 Thursday ,12 OctoberEgyptian Bourse loses EGP 3 bn
GMT 13:12 2017 Thursday ,12 OctoberBahrain Bourse daily performance
GMT 11:06 2017 Thursday ,12 OctoberWall Street ends at fresh records; Spanish stocks gain


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Antitrust and Trade Regulation laws aim to promote free competition in the marketplace. Agreements or cooperative efforts by two or more entities that affects or restrains competitors is illegal under these laws. The Sherman Act makes illegal any contract, combination, or conspiracy in restraint of trade or commerce and makes monopolies and attempts, combinations, or conspiracies to monopolize illegal. The Clayton Act regulate price discrimination, tying and exclusive dealing contracts, stock acquisition and interlocking directorates.
Warren is a town in Washington County, Vermont, United States. The population was 1,681 at the 2000 census. The center of population of Vermont is located in Warren. It is set between the two ranges of the Green Mountains, with half the town in the Green Mountain National Forest. Sugarbush Resort, located here is a ski resort, and traversed by the Long Trail, a hiking trail running from the Massachusetts border to the Canadian border.
Antitrust And Trade Regulation Law Lawyers In Warren Vermont


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October 10, 2017
Boost For Ballon D'Or Nominee Hazard
(Sky Sports)
Eden Hazard says his Ballon d'Or nomination is a boost, following his summer injury setback.
Hazard underwent surgery after fracturing his ankle during a training session with Belgium in June, consequently missing the start of the Premier League season before returning to action in September.
Since returning to fitness, the 26-year-old Belgium captain has played a key role in helping Roberto Martinez's side top Group H to seal a place in next summer's Russia World Cup.
Hazard joins fellow Belgium internationals Dries Mertens and Kevin de Bruyne on receiving a Ballon d'Or nomination and, ahead of their final World Cup Qualifier, Hazard said: "I missed football for three months. It is not easy to come back.
"I worked during the summer. I just want to play football.
"I just want to play football and try to bring the best out of me."
It is the fourth time the Belgian has been shortlisted for the prestigious award, having received nominations in 2013, 2014 and 2015.
Asked whether he is back to his best, the forward admits it's too soon into the campaign to tell, Hazard said: "I don't know. I will say at the end of the season."
Belgium host Cyprus on Tuesday night, live on Sky Sports Football, with Tottenham's Jan Vertonghen poised to set a new record as the nation's all-time highest appearance maker.
The 30-year-old equalled former midfielder Jan Ceulemans' 96 caps and marked the landmark with a goal in Saturday's 4-3 win over Bosnia and Herzegovina.
Manchester United striker Romelu Lukaku is "100 per cent fit" for selection, the manager confirmed.
Lukaku's been a doubt after an ankle injury ruled him out against Bosnia.
United team-mate Marouane Fellaini will not feature in the side, after suffering ligament damage at the weekend.
"We had the scan and it was a damage in the ligament. The damage could be very little, or very big," Martinez said.
"I think in the next few days we will have a clear idea of what the final state of the injury is."


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Bioprojet Biotech
Bioprojet Biotech
Bassetti C.L.,Neurocenter EOC of Southern Switzerland |
Baumann C.R.,Neurocenter EOC of Southern Switzerland |
Dauvilliers Y.,French Institute of Health and Medical Research |
Croyal M.,Bioprojet Biotech |
And 2 more authors.
Journal of Sleep Research | Year: 2010
Histaminergic neurons of the hypothalamic tuberomammillary nucleus constitute a major wake-promoting system. In animals, cerebrospinal fluid (CSF) histamine levels are increased during wakefulness and after sleep deprivation and decreased during sleep. An involvement of the histamine system in human disorders has not, to our knowledge, been reported. We measured hypocretin-1 and histamine levels in the lumbar CSF of 28 patients with and without excessive daytime sleepiness (EDS) as assessed by the Epworth Sleepiness Scale (ESS). There were 10 patients with EDS (ESS > 10, mean ESS = 14). Diagnoses included narcolepsy (n = 4), idiopathic hypersomnia (n = 2), sleep apnoea (n = 2) and multiple sclerosis (n = 2). Three patients were treated with stimulants. Their mean CSF histamine was 258 ± 159 PM. There were 18 patients without EDS (ESS < 9, mean ESS = 5). No patients were treated with stimulants. Their mean CSF histamine was significantly higher (624 ± 481 PM, P = 0.007). There was a significant inverse correlation (r = -0.48, P = 0.02) between ESS and both CSF histamine and hypocretin-1 levels. These observations suggest that narcolepsy and EDS of other origin are associated in humans with lower CSF histamine levels and therefore with a reduced activity of the wake-promoting histaminergic neuronal system. © 2010 European Sleep Research Society.
Uguen M.,Bioprojet Biotech |
Perrin D.,Bioprojet Biotech |
Belliard S.,Bioprojet Biotech |
Ligneau X.,Bioprojet Biotech |
And 3 more authors.
British Journal of Pharmacology | Year: 2013
BACKGROUND AND PURPOSE: Pitolisant, a histamine H3 receptor inverse agonist/antagonist is currently under Phase III clinical trials for treatment of excessive daytime sleepiness namely in narcoleptic patients. Its drug abuse potential was investigated using in vivo models in rodents and monkeys and compared with those of Modafinil, a psychostimulant currently used in the same indications. EXPERIMENTAL APPROACH: Effects of Pitolisant on dopamine release in the nucleus accumbens, on spontaneous and cocaine-induced locomotion, locomotor sensitization were monitored. It was also tested in three standard drug abuse tests i.e. conditioned place preference in rats, self-administration in monkeys and cocaine discrimination in mice as well as in a physical dependence model. KEY RESULTS: Pitolisant did not elicit any significant changes in dopaminergic indices in rat nucleus accumbens whereas Modafinil increased dopamine release. In rodents, Pitolisant was without any effect on locomotion and reduced the cocaine-induced hyperlocomotion. In addition, no locomotor sensitization and no conditioned hyperlocomotion were evidenced with this compound in rats whereas significant effects were elicited by Modafinil. Finally, Pitolisant was devoid of any significant effects in the three standard drug abuse tests (including self-administration in monkeys) and in the physical dependence model. CONCLUSIONS AND IMPLICATIONS: No potential drug abuse liability for Pitolisant was evidenced in various in vivo rodent and primate models, whereas the same does not seem so clear in the case of Modafinil. © 2013 The British Pharmacological Society.
Shah R.R.,8 Birchdale |
Maison-Blanche P.,Hopital Bichat |
Duvauchelle T.,Bioprojet Pharma |
Robert P.,Bioprojet Biotech |
Denis E.,Bioprojet Biotech
European Journal of Clinical Pharmacology | Year: 2015
Objective: To compare the effect of moxifloxacin as a positive control in a single ascending dose (SAD) study with that in a thorough QT (TQT) study. Methods: Moxifloxacin was used as a positive control in a SAD study and a TQT study during the evaluation of the QT liability of a new drug. The SAD study had enrolled 24 males and the TQT study 25 males. Both studies intensively monitored electrocardiograms (ECGs) and pharmacokinetic sampling. Effect of moxifloxacin on QTc interval was analysed in each study by intersection union test (IUT) and by exposure-response (ER) analysis and the results compared. Cost-effectiveness of this approach was computed. Results: Analysis by IUT revealed that the maximum mean (90 % confidence interval (CI)) placebo-corrected change from baseline (ΔΔQTcF) in the SAD study and the TQT study were remarkably similar (10.7 (6.5; 14.9) ms vs. 9.09 (6.20; 11.98) ms, respectively). In both studies, assay sensitivity was established by the 90 % lower bound exceeding 5 ms. ER analysis revealed the slopes in both studies to be significantly different from zero and comparable. Bootstrap-predicted effects of moxifloxacin at geometric mean concentrations of ~3000 ng/mL were 8.19 (90 % CI 5.86; 10.7) ms in the SAD study and 7.33 (90 % CI 5.69; 9.70) ms in the TQT study. Conclusion: Moxifloxacin can be integrated effectively in a SAD study to establish assay sensitivity, and a TQT study may be replaced by a SAD study which has the required assay sensitivity. Further experience is warranted to verify this conclusion. © 2015 Springer-Verlag Berlin Heidelberg.
Jacolot M.,University of Rennes 1 |
Jean M.,University of Rennes 1 |
Levoin N.,Bioprojet Biotech |
Van De Weghe P.,University of Rennes 1
Organic Letters | Year: 2012
We report a TMSI-promoted Prins cyclization reaction with ketones as carbonyl partners to prepare polysubstituted chiral spirotetrahydropyrans. In the presence of racemic 2-methylcyclohexanone a dynamic kinetic resolution occurred affording one stereoisomer. The observed enantiospecificity has been rationalized by DFT calculation. © 2011 American Chemical Society.
Legouin B.,University of Rennes 1 |
Gayral M.,University of Rennes 1 |
Uriac P.,University of Rennes 1 |
Cupif J.-F.,University of Rennes 1 |
And 3 more authors.
European Journal of Organic Chemistry | Year: 2010
A chiral molecular tweezer obtained from (+)-usnic acid placed in solution in the presence of various aromatic compounds afforded complexes with low association constants. Thus, the X-ray structure of assembly 31 is presented, where the guest is sandwiched between the two pincers of the tweezer. The association constants for various guests were determined through different methods. Finally, other tweezers with electron-rich aromatic aldehydes and ketones were prepared from (1R,2R)-1,2-diaminocyclohexane. The most interesting complexes were also confirmed through structural analysis, and the best results were obtained with 10-hydroxyphenanthrene-9-carbaldehyde (51) as the aromatic moiety. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Wicek M.,Jagiellonian University |
Kottke T.,Goethe University Frankfurt |
Ligneau X.,Bioprojet Biotech |
Schunack W.,Free University of Berlin |
And 4 more authors.
Bioorganic and Medicinal Chemistry | Year: 2011
Previous studies have shown that several imidazole derivatives posses affinity to histamine H3 and H4 receptors. Continuing our study on structural requirements responsible for affinity and selectivity for H3/H4 receptor subtypes, two series of 3-(1H-imidazol-4-yl)propyl carbamates were prepared: a series of unsaturated alkyl derivatives (1-9) and a series possessing a cycloalkyl group different distances to the carbamate moiety (10-13). The compounds were tested for their affinities at the human histamine H3 receptor, stably expressed in CHO-K1 cells. Compounds 1, 2, 5-7, 10-13 were investigated for their affinities at the human histamine H4 receptor co-expressed with Gαi2 and Gβ1γ2 subunits in Sf9 cells. To expand the pharmacological profile, compounds were further tested for their H3 receptor antagonist activity on guinea pig ileum and in vivo after oral administration to mice. All tested compounds exhibited good affinity for the human histamine H3 receptor with Ki values in the range from 14 to 194 nM. All compounds were active in vivo after peroral administration (p.o.) to Swiss mice, thus demonstrating their ability to cross the blood-brain barrier. The most potent H3 receptor ligand of these series was compound 5, 3-(1H-imidazol-4-yl)propyl pent-4-enylcarbamate with the highest affinity (Ki = 14 nM). Additionally, compound 3 showed remarkable central nervous system (CNS) H3R activity, increasing the Nτ-methylhistamine levels in mice with an ED 50 value of 0.55 mg/kg, p.o. evidencing therefore, a twofold increase of inverse agonist/antagonist potency compared to the reference inverse agonist/antagonist thioperamide. In this study, the imidazole propyloxy carbamate moiety was kept constant. The different lipophilic moieties connected to the carbamate functionality in the eastern part of the molecule had a range of influences on the human H4 receptor affinity (154-1326 nM). © 2011 Elsevier Ltd. All rights reserved.
Croyal M.,Bioprojet Biotech |
Dauvilliers Y.,Montpellier University Hospital Center |
Labeeuw O.,Bioprojet Biotech |
Capet M.,Bioprojet Biotech |
And 2 more authors.
Analytical Biochemistry | Year: 2011
An ultra-performance liquid chromatography tandem mass spectrometry (UPLC™-MS/MS) assay was developed for the simultaneous analysis of histamine, its major metabolite tele-methylhistamine, and an internal standard (N-tele-(R)-α-dimethylhistamine) from human cerebrospinal fluid (CSF) samples. The method involves derivatization of primary amines with 4-bromobenzenesulfonyl chloride and subsequent analysis by reversed phase liquid chromatography with mass spectrometry detection and positive electrospray ionization. The separation of derivatized biogenic amines was achieved within 3.5 min on an Acquity® BEH C18 column by elution with a linear gradient of acetonitrile/water/formic acid (0.1%). The assay was linear in the concentration range of 50-5000 pM for each amine (5.5-555 pg/ml for histamine and 6.25-625 pg/ml for tele-methylhistamine). For repeatability and precision determination, coefficients of variation (CVs) were less than 11.0% over the tested concentration ranges, within acceptance criteria. Thus, the developed method provides the rapid, easy, highly sensitive, and selective requirement to quantify these amines in human CSF. No significant difference was found in the mean ± standard error levels of these amines between a group of narcoleptic patients (histamine = 392 ± 64 pM, tele-methylhistamine = 2431 ± 461 pM, n = 7) and of neurological control subjects (histamine = 402 ± 72 pM, tele-methylhistamine = 2209 ± 463 pM, n = 32). © 2010 Elsevier Inc. All rights reserved.
Dauvilliers Y.,Montpellier University Hospital Center |
Dauvilliers Y.,French Institute of Health and Medical Research |
Dauvilliers Y.,Montpellier University |
Delallee N.,Bioprojet Biotech |
And 9 more authors.
Sleep | Year: 2012
Study Objectives: To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. Design: A sensitive liquid chromatographic-electrospray/tandem mass spectrometric assay was developed for the simultaneous quantification of CSF HA and t-MHA. Setting: Data were collected and CSF hypocretin-1 levels were measured using radioimmunoassay at the Sleep Disorders Center, Montpellier, France. CSF HA and t-MHA were measured in Bioprojet-Biotech, France Participants: One hundred fourteen unrelated patients with a suspicion of central hypersomnia underwent one night of polysomnography followed by the multiple sleep latency test. Sleep disorders were diagnosed clinically and using sleep studies: narcolepsy-cataplexy NC (n = 56), narcolepsy without cataplexy NwC (n = 27), idiopathic hypersomnia IH (n = 11), secondary narcolepsy (n = 3), and unspecified hypersomnia Uns EDS (n = 17). Fifty neurological patients without daytime sleepiness were included as controls. Measurements and Results: No between-hypersomnia group differences were found for CSF HA levels (median 708.62 pM extreme range [55.92-3335.50] in NC; 781.34 [174.08-4391.50] in NwC; 489.42 [177.45-906.70] in IH, and 1155.40 [134.80-2736.59] in Uns EDS) or for t-MHA levels. No association was found between CSF HA, t-MHA, or HA + t-MHA, sleepiness, treatment intake, and frequency of cataplexy. A slight negative correlation was found between age and HA levels. Further adjustment for the age revealed no significant HA levels difference between hypersomnia patients and controls. Conclusion: CSF histamine and tele-methylhistamine did not significantly differ between patients with narcolepsy-cataplexy and other etiologies of non-hypocretin-1 deficient central hypersomnias; these measurements, therefore, are not useful in assessing the etiology or severity of centrally mediated hypersomnia.
Gros D.,Institut Universitaire de France |
Theveniau-Ruissy M.,Institut Universitaire de France |
Bernard M.,Aix - Marseille University |
Calmels T.,Bioprojet Biotech |
And 6 more authors.
Cardiovascular Research | Year: 2010
AimsThis study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart.Methods and resultsThe expression of the Gjb6 gene in the mouse heart was investigated by RT-PCR and sequencing of amplified cDNA fragments. The sites of Gjb6 expression were identified in the adult heart using transgenic mice with reporter genes (Cx30LacZ/LacZ and Cx30LacZ/LacZ/Cx40 EGFP/EGFP mice), as well as anti-HCN4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4) or anti-connexin antibodies. Cine-magnetic resonance imaging and telemetric ECG recordings were used to evaluate the impact of Cx30 deficiency on cardiac physiology. Gjb6 was shown to be expressed in the sinoatrial (SA) node of the adult mouse heart. Eighty from 100 nuclei on average were LacZ-positive in the SA node of Cx30 LacZ/LacZ mice. No significant LacZ expression was seen in other cardiac tissues. Cx30 protein was identified in low abundance in the SA node of wild-type mice, as indicated by immunofluorescence experiments. Telemetric ECG recordings indicated that Cx30-deficient mice displayed a mean daily heart rate (HR) that was 9 faster than that measured in control mice (572 ± 38 b.p.m. vs. 524 ± 23, P < 0.05). This moderate tachycardia was still observed after inhibition of the autonomic nervous system, demonstrating that Cx30 deficiency resulted in changes in the intrinsic electrical properties of the SA node. Consistent with this hypothesis, Cx30LacZ/LacZ displayed a significant reduction of SDNN (standard deviation of the interbeat interval) compared with control mice. Increase of both the cardiac index (20) and the end-diastolic volume to body weight ratio (16) with no deficiency in ejection fraction or stroke volume were observed in mutant mice. An increase in cardiac index was interpreted as being a direct consequence of high HR, whereas large end-diastolic volume may be an indirect consequence of prolonged high HR.ConclusionCx30 is functionally expressed, in low abundance, in the SA node of the adult mouse heart where it participates in HR regulation.
PubMed | Bioprojet Biotech
Type: | Journal: Methods in molecular biology (Clifton, N.J.) | Year: 2017
This work aimed at building a 3D model of trimeric apo CD95. By combining different molecular modeling approaches and experimental information, we have been able to obtain a consensual organization of the complex. Our strategy permitted the construction of a plausible trimer, and to sketch the interface between protomers. The final model will guide further experimental investigations and understanding of CD95 structure and functions.


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Ministries - YouthTo lead youths to Jesus by strategically building relationships with them, while providing a nurturing and wholesome spiritual environment that will help combat present secular issues, such as peer pressures and family problems. To also propel them for spiritual elevation and enrichment as they become successful in Christ Jesus.
Back to Ministries


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Last Update date : 2017.09.11
The Digital Inverter Motor is brushless, so it runs much cooler and uses less energy than motors found in conventional washing machines.
Brushless motors have a small number of moving parts, giving them a longer lifespan. That's why Samsung can back the motor of our next-generation washing machines with a 11-year parts warranty.
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This article covers the retiring support for Recall version 1.11.7. If you are still running this version of Recall, please upgrade your application immediately.
Due to upgrades to our back-end systems, support for Recall version 1.11.7 (and prior) will be retired immediately. This means that you will no longer be able to use the Recall app to sign in, search, or find results. If you are still running this outdated version, please upgrade to the latest build immediately.
You can do so by following these steps:
Click on the Atlas icon in your menu bar:
From this drop down menu, you can select 'Check for Updates.'
Recall will prompt you to download and install if there is an update available.
If you have questions or feedback, please contact us at email@example.com


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|Educating Teens About Traffic Stops
Traffic stops for all of us—and especially teens—often create the following concerns:
the element of surprise • lack of forethought • spontaneous reactions
"PULL OVER: have no regrets," a teen driver education program, developed by PursuitSAFETY, meets these three concerns for teen drivers head-on. The PursuitSAFETY team works with law enforcement, schools, and existing driver training classes involved in the expansion of the teen drivers education system. To offer today's youth a complete package, include "PULL OVER: have no regrets" in your teen drivers education program. We will attend your train the trainer programs.
Educate teens about traffic stops to help keep everyone safe!
Teen Drivers: PULL OVER Handout Two-sided (pdf)
PursuitSAFETY, founded in 2007, is a leading national 501(c)(3) nonprofit organization dedicated to reducing the number of vehicular police pursuits. Most government agencies recognize that people in their teens and early 20s flee from police more than any other age group.
View downloadable videos, click here.
Questions? Contact Candy Priano at 530-343-9754 or email@example.com


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5708 E Sleepy Ranch Road, Cave Creek, Arizona
$675,0003 Beds3 BathsActive
$675,0003 Beds3 BathsActive
5708 E Sleepy Ranch Road, Cave Creek, Arizona 85331 - Enjoy views of Black Mountain from this stunning LENNAR ''Torrey Pines'' home in prestigious gated community of Lone Mountain Estates. Designed for entertaining, the backyard faces a desert wash and features a custom travertine paver patio and decking, pebble tech private pool with water features. Entertain in style with your built-in BBQ and beautifully landscaped yard with easy care ''top of the line'' synthetic grass by Southwest Greens.The Gourmet Kitchen is a ''chef's Dream with GE Monogram stainless steel appliances, including a 6 burner gas range, with griddle & range hood, granite countertops, pantry, wine refrigerator & much more!This home has many upgrades. The interior features ''new'' hardwood flooring, a stacked stone backslash behind the cooktop and around the center isle
Listing Courtesy of Russ Lyon Sotheby's International Realty
"No words that could ever convey my appreciation for your dedication to my child. Have spent the last three days moving the kids into their new home! We are all exhausted, but in a wonderful way. The first night Bela spent there he sent me a text that said "Out swimming in my own pool. Victory!" As parents I'm sure both of you can understand the joy that filled my heart with that text. The first house Bela's dad and I ever bought was 3 bdrm/1 bath/900sq ft/ and I raised three kids there!!! The "Bales" (as we call them) are starting out at almost 2400 sq feet with a mother in law suite and 3 other bedrooms and bathrooms! Crazy, but wonderful. There are just no words that could ever convey my appreciation for your dedication to my child. (and the crazy redhead)? Tired, exhausted, and sore, but loving you all the while. And I know I speak for everyone. Can't wait for the housewarming!!! YOU GUYS ROCK!!!!!"


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| Clip Of Women's Clothing in Colonial America This clip, title, and description were not created by C-SPAN.
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As a teacher, I learned the need to emphasize that creativity does not equal thoughtless action; indeed, it takes much more complex and active thinking skills than those demanded by a traditional academic educational system.
I am excited to integrate recent multimedia technologies, such as blogging, digital photography & film, animation, and web design into these core creative thinking modules. I hope to make the online lessons as interactive and "hands-on" modules to complement in-class activities.
Which are the elements or characteristics that describe optimal language learning activities and environments?
Joy Egbert (2005, CALL Essentials: Principles and Practice in CALL classrooms, TESOL) identifies the following conditions for classroom language learning:
Any language lesson should support conditions for optimal classroom language learning environments regardless of the tools used. These conditions based on research from a variety of literatures, have been characterized in different ways, but a general list (Egbert & Hanson-Smith, 1999) includes the following eight items:
Learners have opportunities to interact socially and negotiate meaning.
Learners interact in the target language with an authentic audience.
Learners are involved in authentic tasks.
Learners are exposed to and encouraged to produce varied and creative language.
Learners have enough time and feedback.
Learners are guided to attend mindfully to the learning process.
Learners work in an atmosphere with an ideal stress/anxiety level.
Learner autonomy is supported.
Now let's compare these optimal environmental conditions with Chapelle (1998) hypotheses, derived from the Interactionist Theory, for developing multimedia CALL:
The linguistic characteristics of the target language input need to be made salient.
Learners should receive help in comprehending semantic and syntactic aspects of linguistic input.
Learners need to have opportunities to produce target language output.
Learners need to notice errors in their own output.
Learners need to correct their linguistic output.
Learners need to engage in target language interaction whose structure can be modified for negotiation of meaning.
Learners should engage in L2 tasks designed to maximize opportunities for good interaction.
It seems that the focus on linguistic form (hypotheses 1 and 2) and learners error noticing and correction (hypotheses 4 and 5) are not present in Egbert's conditions (although "learners having feedback" is somehow related to "error noticing"), perhaps because these refer to environmental conditions and Chapelles's hypotheses refer to materials development. Another difference is that Egbert's emphasis on authentic tasks and audience is not present in Chapelle's list.
The characteristics of learning activities are mainly defined by the type of tasks learners are engaged in. Doughty and Long (2003) used Task-Based Language Teaching theory to derive ten methodological principles, or language teaching universals, which may guide the design of ideal tasks.
It is generally believed that education is of vital importance in individual's development and well-being of societies. What should education consist of to fulfill both these functions?With the rapid development of modern society, education is becoming more and more crucial to both individuals and societies. The issue over what education should consist of has considerably aroused people's wide concern. In this essay, I seek to explore this complicated topic from diverse perspectives and what influence could be brought.Among the most important aspects education should consist of, one should be stressed is professional knowledge education. On one hand, under the fierce competitive circumstance, people who have professional skills and experience more opportunities companies. Therefore, study about one special area gives people more opportunities to hunt an ideal job. On the other hand, this education is also significant to develop societies in a long run.At the second place, what is also worth noticing is that physical education is necessary for students, especially for teenagers. If you want to achieve successfully in the modern societies, strong body is the first premise, which makes you always in shape. So education should push people to take care themselves and this could bring great benefits to the healthy society. Last but not least, we should not lose sight of psychological education. Psychological problem are serious nowadays and a sizable percentage of people suffer from them. A survey conducted by a famous research organization indicates that over 40 percent of students have various psychological problems, which really need help from school and society. Even worse, if such problems, cannot be solved, they could hamper the progress of well-being society.Judging from what I have been discussed above, we may safely draw the conclusion that three aspects cannot be separated in education, which play vital important roles in the growth of individuals and societies. The fulfillment of both people and societies can be done as long as we lay emphasis on three aspects mentioned above.
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Steven Soderbergh Shares a 1984 Rejection Letter From Lucasfilm
Posted on Wednesday, October 18th, 2017 by Hoai-Tran Bui
If you're struggling with job rejection after job rejection in your 20s, don't worry. Rome wasn't built in a day, nor was Steven Soderbergh an indie darling director immediately after he joined the film industry. It took work, and rejection by one of the top movie studios of the day.
In April 1984, Soderbergh was an aspiring 21-year-old filmmaker scraping by as a game show scorer and a freelance film editor. But in an effort to break into Hollywood, he decided to send a demo reel of short films shot on Super 8mm to Lucasfilm. They rejected him. And Soderbergh still has the letter.


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My band Abstract Prayer is playing with thrash legends Exodus at Chain Reaction! If you're in the Anaheim area on December 5th you should definitely be there, the tickets are only $13! You know you want to go! If you want you can hit us up on our myspace for tickets, or contact me directly and we can work out getting you your tickets.
me: http://www.myspace.com/christoffa
band: http://www.myspace.com/abstractprayer


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The negative interest rate policy has raised doubts over the potential impact on capital markets as the debate about whether a negative interest rate policy (NIRP) helps or hinders the transmission mechanism of monetary policy continues to rage.
However, International Monetary Fund analysts defend the European Central Bank's negative deposit rate on the weak growth that has now persisted in the eurozone for almost a decade, seeing it as a problem of lack of demand, which can be tackled by adopting an expansionary fiscal policy and an ultra-loose monetary policy.
The central bank is using negative deposit rates to try to prevent the money supply that it has created from disappearing into speculators pockets, a situation which Keynes described as the liquidity trap, and which makes monetary policy ineffective. If the holding of cash is now penalized by negative interest rates, it could be possible to escape from the liquidity trap by encouraging banks to lend, companies to invest and consumers to spend, Deutsche Bank (DB) reported.
Like the ECB, the IMF also says that negative nominal interest rates can prevent excessively high real interest rates, which result from excessively low inflation, from unduly depressing demand. What is known as the natural rate of interest plays a key role in this approach. It describes the level of interest rates at which monetary policy fails to change the growth or inflation rates.
Moreover, NIRP reduces the incentive to change this, both for lenders because of lower profits resulting from falling interest margins and for borrowers, whose interest expense continues to decline. The eurozones crawling growth is likely to persist if companies do not write off their misinvestments and banks their non-performing loans. Negative interest rates will only stretch this process with evergreen and zombie loans, the report added.


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The Wyberton-based G&S Racing Kawasaki team return to Brands Hatch at the weekend for their second visit to the Kent circuit.
They will be riding on the crest of a wave after some excellent results at Knockhill last time.
Dominic Usher scored a strong fifth place in the Superstock 1000 championship and Kevin Van Leuven was 10th in the stock 600 class.
Tom Fisher overcame a heavy crash in free practice to finish 28th in the stock 1000 and took on board some more useful information in his rookie year.
All three riders have raced at Brands Hatch in the past, although this will be the first time Van Leuven has competed on the full GP circuit.
He will have the data from the Indy circuit to work with but has to learn his way around the rest of the track. But no doubt he walked the full circuit during his time there back in April which will help him.
Superstock 1000
Friday: free practice – 11.45am; first qualifying – 3.10pm.
Saturday: final qualifying – 12.45pm.
Sunday: warm-up – 9am; race 16 laps – 12.35pm.
Superstock 600
Friday: free practice – 11.05am; first qualifying – 2.35pm.
Saturday: final qualifying – 12.10pm.
Sunday: warm-up – 9.15am; race 14 laps – 2.15pm.


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This year's keynote speakers will be:
Greg Papadopoulos, Executive Vice President and CTO, Sun Microsystems
Fred Weber, Vice President, Computation Products Group, AMD
Hear announcements from industry leaders including:
ARC International, ARM, ClearSpeed Technology
Fujitsu, IBM, Imagination Technologies, MathStar
MIPS Technologies, Motorola, picoChip Designs
Renesas Technology, Silicon Hive, Sun Microsystems
Transmeta, and the University of Texas at Austin
MPF is your destination for breaking news, insightful analyses, and nonstop networking!
Register before July 31st and receive introductory price savings of up to $1,300.
Register online now at http://www.MDRonline.com/mpf/register/


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HISLOP Genealogy in All Regions
Search criteria: All Regions, Surname HISLOP
What can you do here?
Search online databases for your ancestors:*
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3. Fooks - Deering Family History
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5. 1859 City Directory for Columbia, SC
7. Helena, Lewis and Clark County, Montana: Lewis and Clark County Cemetery
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ESIL Interest Group History Of International Law
It would not be trite to state that any of the ministers of the Council would be incompetent to responsibly train the powers of the Prime Minister. If these requirements of conduct are not adopted, the regulation kinds the battle that arises, and punishes those that breach the standards of conduct. Common Law is stuffed with technicalities, rigidity and harshness, because of its incapacity to offer any redress to a litigant in certain instances. None of the material on this web site is expressly or impliedly meant to offer legal advice to you.
This listing is a broken down model of the main points of the Law of Attraction and the way it can be just right for you. Mental toughness is what it's essential get by means of some severe hardships comparable to legal problems, bankruptcy, job loss, most cancers. We are dedicated to advancing the understanding of law and authorized issues in their domestic, comparative and worldwide contexts; engaging in high quality legal scholarship; and selling and inspiring ethical and professional approaches to the examine and practice of law.
Ingo Venzke, University of Amsterdam, Amsterdam Center for International Law, is publishing Sources and Interpretation Theories: The International Lawmaking Process in Oxford Handbook on the Sources of International Law (Samantha Besson and Jean d'Aspremont eds, Oxford University Press, 2017). A motion that begun on the margins of the authorized world, via the work of individuals like Loyola 2L, and Scott Bullock of Big Debt/Small Law, and Nando of Third Tier Reality, has gone mainstream. The largest cause the authorized discipline grew to become glutted was that back in the day regulation college was off limits to a sure class / type of individuals. Later, mourning, as well as luxurious kinds, became regulated by social convention instead of law. After you have a look at the scenario for a while, you begin to notice that the regulation's best attraction is its ease and simplicity.
Federal, state/provincial, county/parish, and native legal guidelines and regulations govern these scenarios and it could be finest to name the suitable courts and penal techniques in question in order to discover out the precise necessities for each. I love the science behind Law of Attraction and you've collected it and presented it in A style.
When a woman brought land into the marriage, the husband often had legal control over it (although whether he truly controlled, or she did, relied on the couple), but courts normally recognized her legal ownership. You'll love learning EU Law for those who like politics, in case you are a visionary, if you're a pragmatist. Douglas Barr, Heather Thomas and Markie Post rounded out the supporting forged they usually have been great at the job.


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2015 hasn't been an easy year for Alibaba, China's biggest online retail giant. Its share price has dropped by 24% since it launched its IPO in September last year. Its revenue was $3.2bn, a growth of 28% lower than the expectation of $3.39bn. It has also reported the slowest quarterly growth in the past three years. This dramatic fall in its short-term profitability has worried investors.
So what is Alibaba?
Alibaba allows a business in the UK to find a manufacturer in China and have a range of goods produced and shipped. It's not just businesses that use Alibaba's websites. It also owns taobao.com, China's largest shopping website, and tmall.com, which offers a wide selection of branded goods to China's emerging middle class. Alibaba's reach does not end there, it also runs the online payment system alipay.com, which operates in a similar manner to Paypal. It also has a large stake in Sina Weibo, China's version of Twitter, and the online video provider, Youku Tudou, which operates in a similar way to YouTube. The company also offers online marketing, cloud computing and a logistics operation. Alibaba claimed the title for the largest global IPO in stock exchange history in September last year when demand for its share was way over expectation.
The Strategy Shift
In future quarters, a weaker renminbi will be a drag on dollar-dominated results. The company's growth was mainly crimped by Chinese authorities suspending online lotteries and the transfer of its lending business to a sister company. Alibaba's operating margin fell to 52%. The company says it reflects its investment in digital payments and cloud computing.
Alibaba has been successfully transformed itself at the time when many consumers are moving to mobile internet. Alibaba has used the rapidly increasing online market to pioneer smartphone technology in the country, and now controls over 75% of all mobile retail in China. Results have shown that over half of the group's revenue is generated by its mobile site.
Recently, Alibaba has announced that it will invest $4.6bn in a 19.99% stack in China's largest physical electronics retailer, Suning. Suning will also invest $2.25bn in Alibaba in return for a 1.1% stack of the company. This strategy shift has concerned investors, given the company's performance has been way under expectation since the launch of its IPO and the magnitude of the size of investment made by Alibaba in its core business and other areas. On the other side of the coin, this creates a link between the company's online services and traditional retailers and businesses: a trend known as ''Online-to-Offline''- that Alibaba is hoping to tap into. Suning, which has about 1,600 shops in China, said customers would be able to browse electronics in its stores before purchasing the item on Alibaba's site. It also said its network of physical stores would join forces with Alibaba's distribution operations to cut the delivery time of goods to customers – to as little as two hours.
Although some investors think they could benefit from this shift in strategy, this doesn't affect the others' disappointment from its poor performance in the last two quarters. Billionaire George Soros's family office sold almost its entire stake in Alibaba Group Holding Ltd.


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Catherine Nasmith at Alton Mill
Catherine Nasmith
Love of craft keeps me designing and building projects for diverse clients and advocating for conservation of the built and natural environment. It was the opportunity to create that drew me to architecture in the first place, and has kept my interest.
The quest for places that lift the spirits has driven a lifetime of collaboration with individual clients, community organizations and urban activism.
Old buildings teach us how to live lightly on the land, about our roots and who we are. Revealing a building's story and recycling it for a new use is work worth doing. Insertions are of their day, and live comfortably with the artfully recycled.
Architecture depends on enthusiastic patrons and expert builders. I have been lucky on both counts.


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The quality of saddles and decorations on the horse served as a distinctive sign of the person's solvency.
The oldest man sites found in the Baikal region are about 25 thousand years. We cannot tell if these were the ancestors of the tribes that lived here later or not. Scientists still argue who constituted the indigenous population of Eastern Siberia.
However, we can look at the peculiarities of some nations living near Lake Baikal or those who once lived there.
The renaissance of the culture of the qurykan people in the Baikal region fell to VI-X century. They settled from the Tunkinskaya to Barguzinskaya valleys, the union of qurykan tribes led a semi-settled or nomadic way of life. The main occupation was cattle breeding: they bred goats, camels and horses. Qurykans were also engaged in farming - plowing fields, in balcksmith's business - making weapons, everyday items and tools. The cultural level of the people was very high: art and writing were developing, complex religious cults were present. The decline of the culture fell to the 10th century, when the Mongol tribes came to the Baikal region. Some of the qurykan people went to the North under pressure, and the remaining part mingled with Mongols and became the progenitors of Buryats.
Buryats constitute one of the most numerous nations living in Siberia. The former basis of their household economy was nomadic herding which gave food, clothing and felt for the construction of dwellings. Buryats bred sheep, goats, camels, horses. Agriculture was poorly developed, but after the arrival of Russians they started to engage in agriculture more actively, adopting the new neighbors' plow and other tools. Men went fishing and hunting: in winter they hunted squirrel, sable, fox, otter, and in summer - elk.
Blacksmiths made various items of metal. This profession was hereditary, blacksmiths were often shamans at the same time.
Horses occupied a special place in the life of Buryats, because these animals were considered pure. They were used in the household not only as a transportation means. Horse-breeding products were widely spread: horse meat was considered the most delicious dish, hair was used for the manufacture of ropes and nets, leather served for sewing shoes.
The quality of saddles and decorations on the horse served as a distinctive sign of the person's solvency.
The basis of a traditional Buryat dwelling, "yurt", consisted of easily transported latticed walls that were covered with felt and tied up with ropes. An entrance to a yurt has always been directed to the South. The insides of the dwelling were divided into two halves: the western one belonged to men, the eastern one – to women. The hotbed was placed in the centre.
Nowadays Buryats live in Buryatia, Irkutsk Oblast, Trans-Baikal Territory and other regions of Russia, as well as in Mongolia and China. Their population amounts to about 690,000 people.
The nation of Evenks was formed by mixing of the Eastern Siberian indigenous tribes with the Tungus tribes of the Trans-Baikal Territory. The tribes settled along the shores of Lake Baikal, rivers Angara and Lena and later moved on. Today Evenks live on the territory from Yenisei to Amur.
Ethnographers awarded Evenks with the nickname of "Taiga Gypsies" for their nomadic way of life: they move through the taiga in search of new places for hunting, transporting their light dwellings ("chums") and all property on reindeer.
Evenks have been engaged in hunting, fishing and cattle breeding since ancient times. There were three basic types of Evenks (according to occupation): hunters "lamuchens", reindeer-breeders "orochens" and horse-breeders "khamnigans". Reindeer-breeding was well developed in all communities, anyway. Reindeer for Envenks are not just pets, but a symbol of prosperity and wealth of the family, the main means of transportation and a source of food. An old Evenki saying goes: Evenks are alive as long as the reindeer are alive.
Different cults have a great importance, Evenks are taught to respect them since childhood. For example, there is a cult of the bear, the owner of taiga, which obliges each hunter to kill only a strictly determined number of bears - otherwise the hunter may die soon.
Today there are about 77 thousand Evenks living in Yakutia, Irkutsk Oblast, Krasnoyarsk Territory and other places.
A small semi-nomadic people - tofalars – live on the territory from Nizhneudinsky District to the North-Eastern slope of the Eastern Sayan Mountains. Their traditional occupations were and remain hunting and nomadic reindeer-breeding. These are skilful hunters and pathfinders who hunt different animals in different seasons: elk, red deer, roe deer, sable, beaver, fox, wolverine and other taiga animals.
Patrimonial pattern of tofalars' life survived until the middle of the 20th century. A great importance in the public life belonged to annual December meetings of all families, "suglans", that served to elect men to some positions and solve important problems.
Tofalars are one of the small-numbered indigenous peoples of Russia. Now there are only about 800 of them.
According the culture of many ancient peoples, man is a drop of the rain in comparison to the nature, but not its king. Nature is the supreme intelligence, where Baikal and everything connected with it has been revered, guarded and even deified for centuries.
People traveling to Lake Baikal (especially to the areas which are sacred for the Buryats) often have to encounter distrustful views of the local population, and this can be explained by the fact that the entry to some places it is strictly prohibited for women.
The expression "Baikal is a mystical place of power" has became an axiom. Baikal keeps many mysteries and miracles, interesting legends and fairy-tales. The atmosphere of the lake is impregnated with paranormal and abnormal phenomena: the attempts to describe them have been made by the indigenous inhabitants of Baikal region with the help of folk art for many centuries. There are also a number of quite "young" legends which include a story about mysterious (witch) circles.
Myths, legends and songs have been composed about the ancient lake since hundreds and dozens of years ago. The article will feature the most popular and well-known songs about Baikal.


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Paula M's Portland, OR, USA
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Bill's Steak House and Silver Buckle Lounge
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H5O bistro & bar - CLOSED
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• MLB: White Sox 8, Cubs 6. A.J. Pierzynski hit a 3-run home run to win it for the White Sox, but then the Cubs fans pelted the field with garbage, so that'll teach him to never do it again.
• NASCAR: Tony Stewart wins Pepsi 400. And then, in the most athletic maneuver anyone performed there all day, Tony Stewart climbed a fence to celebrate with his fans.
• MLB: Indians 12, Reds 7. Pinch hit grand slams are nice. That is, unless your fantasy team is playing against Travis Hafner.
• MLB: Royals 8, Cardinals 7. The Royals, clearly, are the best team in baseball.


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Clay County Sheriff's Office 41771 Alabama 77 Ashland AL 36251 7.5 miles from Lineville 256-354-2176
Randolph County Sheriff's Office 1st St NE Wedowee AL 36278 15.3 miles from Lineville 256-357-4545
Talladega County Sheriff's Office 148 East Street North Talladega AL 35160 22.0 miles from Lineville 256-362-2748
Calhoun County Sheriff's Office 400 West 8th Street Anniston AL 36201 24.0 miles from Lineville 850-674-5049
Cleburne County Sheriff's Office 120 Vickery St Heflin AL 36264 25.4 miles from Lineville 256-463-2277
Tallapoosa County Sheriff's Office 316 Industrial Park Drive Dadeville AL 36853 34.4 miles from Lineville 256-825-4264
Chambers County Sheriff's Office 2 Lafayette Street South La Fayette AL 36862 35.1 miles from Lineville 334-864-4341
Heard County Sheriff's Office 11820 Georgia 100 Franklin GA 30217 37.2 miles from Lineville 706-675-3329
Coosa County Sheriff's Office 296 School St Rockford AL 35136 39.0 miles from Lineville 256-377-2211
Carroll County Sheriff's Department 1000 Newnan Road Carrollton GA 30116 44.3 miles from Lineville 770-830-5888
St Clair County Sheriff's Office 48 6th Street Ashville AL 35953 46.4 miles from Lineville 205-594-2140
A sheriff is an elected law enforcement official for a county. Sheriffs usually have policing jurisdiction over unincorporated areas of the county, though in some states, sheriffs have jurisdiction throughout the state.
In many locations, the sheriff also runs the county jail.
The sheriff keeps records on criminal arrests, incidents reported to the sheriff, traffic collision reports, and other records. Many of these records are available to the public.


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The Humic Acid Boron Magnesium Market research report is a professional and in-depth study on the current state of the Humic Acid Boron Magnesium Market.
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- Name Elena
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Production Citroen Cactus teased!
Shrawan Raja, I'm the Founder & CEO of IndianAutosBlog.com. I love teamwork and talking about cars.
Citroen are currently testing the production version of the beefy Cactus Concept showcased at the Frankfurt Motor Show last month. An implication from seeing fully developed cars testing on the streets is that somewhere in a design studio, an undisguised example can be found.
When the French auto show 'Auto Moto' of TF1 toured one of Citroen's design centers, they were in for a surprise! A Citroen designer, who was having a good day, not only took them through the studio, but teased the production model by partly lifting the veil off the car!
In the same frame we can see other iterations of the Cactus which were rejected or were made for internal purposes.
The production model features the 'Air Bumps' that were shown on the concept which is a soft skin that has air capsules to protect the car from scratches on impact. A (black) B-Pillar which the concept didn't have, as well as door handles can also be seen on this car.
Another image reveals the digital rendering of the car's dashboard. A large screen on the central console, air vents placed at a lower level and a glovebox lid that swings open upwards are the talking points.
Like the Frankfurt Show concept, the car's proportions are slightly larger than the Peugeot 2008. The concept measured 4.21m long, 1.75m wide and 1.53m tall, measurements that could be replicated without huge deviations on the production model.
The Cactus is a member of Citren's C-Line family and would be built on the Efficient Modular Platform 2 (EMP 2) which the company spent €360 million (3,061 crore rupees) to engineer. Its main rival would be the Nissan Qashqai.
[Source – www.tf1.fr]


text: DMC-40 Heavy Death MetalDMC-46 Arcadias KnightsDMX-10 Deck Builder Ogre DX: Kirari! Leo Saga PromotionalAdd a photo to this gallery Dark Soul Creation Gallery ● Rulings ● Tips ● Trivia Retrieved from "http://duelmasters.wikia.com/wiki/Dark_Soul_Creation/Gallery?oldid=303114" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Gallery


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If your dog visited the vet with an ear infection in 2009, he's not alone. Veterinary Pet Insurance, a provider of pet health insurance based in Brea, Calif., recently revealed the top 10 most common causes of veterinary visits in 2009. Topping the list for dogs was ear infection, and topping the list for cats was lower urinary tract disease.
VPI said it receives more than a million claims annually for treatment of cats and dogs. Despite a pet owner's best efforts to keep their animals healthy, data shows that pets are still at risk for ailments that may require repeated trips to a veterinarian's office, according to Carol McConnell, D.V.M., vice president and chief veterinary medical officer for VPI.
The company received nearly 68,000 canine claims for ear infections in 2009 – with an average claim fee of $100 per office visit. For cats, VPI said it received 3,700 medical claims for lower urinary tract disease. Lower urinary tract disease cost cat owners an average of $260 per office visit.
For dogs, the 10 most common conditions were:
- ear infection
- skin allergy
- skin infection/hot spots
- gastritis/vomiting
- enteritis/diarrhea
- bladder infection
- arthritis
- soft tissue trauma
- non-cancerous tumor
- eye infection
The most expensive canine condition on the list (non-cancerous tumor) cost an average of $335 per visit, while for cats, the most expensive condition (periodontitis/dental disease) cost an average of $360 per visit.
Regular physical exams can help prevent and identify certain conditions before they become serious or costly, VPI said.


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What kind of aromatherapy massages are offered at The Centre for Well-Being at The Phoenician?
Answers from Our Experts (1)
The Centre for Well-Being at The Phoenician offers a 50-minute aromatherapy massage as part of its massage menu. A traditional Swedish massage at this Forbes Travel Guide Four-Star spa is enhanced by your choice of scented oil in a gentle, full body treatment. Aimed at ultimate relaxation, the expert masseuses work with your preferences to create a holistic experience by combining the soothing scents with the ultimate in relaxation.


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As a reminder, tomorrow, on Friday, August 16th, at 6:30 PM, there will be a special Mass offered at the Carmelite Monastery on Jefferson Road. The intention of the Mass is for an increase of priestly vocations. Fr. Michael Mayer will be presiding. Holy Mass will conclude with Exposition and Benediction of the Blessed Sacrament.
There was a miscommunication. Fr. Cornelius is still on vacation this Sunday (the 18th of August), so we will pray Evensong again.
Sunday, August 18, 2013Twelfth Sunday after Trinity.
Sung mass, according to the Anglican Use of the Roman Rite.
Trinity XII
Processional: 542 — Jesus shall reign
Gospel: 347 — Alleluia! (2nd tune)
Offering: 156 — Awake, awake to love and work!
Communion Hymn: 190 — Let thy Blood in mercy poured
Recessional: 267 —Holy Father, great Creator
The lessons are taken from the Roman liturgical calendar, but in the RSV-CE edition of the Holy bible.
Today, the feast of the Assumption of the Blessed Virgin, your webmaster observed in the Toronto University church of St. Basil - seen on the right.
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