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February 17, 2013
How Facebook Made a Billion Dollars, Paid No Taxes and Expects a Huge Refund
By Sheila Samples
It's good to be a corporation in America. Despite making $1.1 billion after going public last year, Facebook didn't pay a dime in state or federal income taxes in 2012. Instead, thanks to the social media company's use of a single tax break--the tax deductibility of executive stock options--it anticipates getting a massive refund from the government totaling $429 million. Although Facebook serves as a useful example of what's wrong with the Ameri ...

subset: commoncrawl


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The King of Marvel Exclusives has been pretty quiet ever since they announced their Guardians of the Galaxy 2 and Spider-Man Homecoming POP Vinyls exclusives. But fear not, Funko collectors–we won't have to live in a world without fresh comic-based Marvel Funko POP Vinyls Exclusives for much longer! Coming our way this summer: Funko X-23 Wolverine, Blue Venom and Superior Spider-Man POP Vinyls! And don't worry, Dorbz fans–Funko has new exclusives lined up for you too…Continue Reading →
Category Archives: Funko POP! Vinyls
Back when the first Guardians of the Galaxy movie came out, the existence of Baby Groot in the credits was a secret. Consequently, we didn't see any Baby Groot toys for months after the movie. But evidently, the same type of thing is not gonna happen with Guardians of the Galaxy Vol. 2! Less than a week after GOTG 2 opened, an Amazon Exclusive Funko Teenage Groot POP Vinyl is now up for order!Continue Reading →
Ever since Funko debuted their line of Spider-Man Homecoming POP Vinyls figures at New York Toy Fair 2017 and there was no Iron Man to be seen, I've been assuming the Homecoming Iron Man POP must be exclusive to the Marvel Collector Corps Spider-Man Homecoming box coming next month. But it looks like that's not going to be the case, but Funko has just announced POP Spider-Man Homecoming exclusives–including a Target exclusive two-pack with Iron Man!Continue Reading →
Of the many Funko Marvel Collector Corps boxes that have shipped since the advent of the series, the single most divisive box among subscribers was the MCC Guardians of the Galaxy box that shipped at the end of 2015. Personally, I loved the scarf and ornaments in that box–but not everyone shared my sentiments. But while that box wasn't a unanimous hit, I think the latest one might be! While the Spider-Man Homecoming Box is now up for order, let's have an in-depth review of this month's outstanding GOTG Vol. 2 Box before we look to the future!Continue Reading →
We're officially under one month away from the Guardians of the Galaxy Vol. 2 movie hitting theaters–but only one week away from the deadline to order the Funko Marvel Collector Corps GOTG Vol. 2 Box! Funko has been pretty tight-lipped about the contents of this box since it was announced in February, but we got a major hint today. And by "hint", I mean "complete spoilers for the exclusive POP Vinyl figure included"! It's a cutie, but I suspect this choice will be a divisive one…Continue Reading →
Ever since Funko began their ongoing series of "Rides" sets, it's seemed like releasing the most obvious rider and vehicle set in the entire Marvel Universe was an inevitability. And now, the Spirit of Vengeance and his bike have become a reality–although not in POP Vinyls form! The Funko Dorbz Ghost Rider & Motorcycle Ridez set is now up for order!Continue Reading →
Sharp-eyed readers may have noticed that last month, even though the Specialty Series Exclusive Funko Iceman POP Vinyls figure was announced, it never actually ended up being listed for sale by most online retailers. But patience has paid off for X-Men fans–the Funko POP Iceman figure is now up for order! And he's brought along another exclusive friend, too: Dorbz Iron Fist!Continue Reading →
Tragedy stuck last week when the February 2017 Funko Marvel Collector Corps box I ordered arrived at my doorstep less than a day after I left for New York Toy Fair 2017. Oh, the humanity!! …Okay, that's probably a bit of hyperbole, but it was a disappointment to me to not be home to do an unboxing myself for the first time ever when a new Funko subscription box arrived. But as luck would have it, I have a wife, and I put her to work taking unboxing photos last week, which I'm now using for my Funko Superhero Showdowns review, unboxing and full spoilers…Continue Reading →
Over the weekend at New York Toy Fair 2017, Funko gave us our first taste of their Spider-Man Homecoming vinyl toys and figures. But it turns out that was just a sample of what the Big F has lined up for us, as an expansive variety of Funko Spider-Man Homecoming POP Vinyls, Dorbz, Hero Plushies and Pint-Size Heroes went up for order today!Continue Reading →
I didn't think that there was even a one in a billion chance that Funko–the most prolific collectible toy manufacturer in the land–would come to New York Toy Fair 2017 without something new Marvel-themed to show off. And as it so happens, I was correct, as Funko brought along all of their new Spider-Man Homecoming POP Vinyls and Pint-Size Heroes figures to showcase! And I have to say–these might just be the cutest Peter Parker and Tony Stark figures ever…Continue Reading →
New York Toy Fair 2017–the biggest toy news event of the entire year–is now just barely over a week away! With that in mind, I had thought the Marvel Collector Corps Superhero Showdown Box shipping next week would be the only Funko Marvel news I'd have to talk about before the show. But the King of Exclusives thought otherwise this week, announcing their Emerald City Comic Con Exclusive WWII Captain America POP Vinyl figure!Continue Reading →
When the Funko Iceman POP Vinyl figure was revealed last week as a Specialty Series exclusive, that left just one Funko Dorbz X-Men figure without a POP Vinyls counterpart… until now! After debuting in vinyl figure form at New York Comic Con 2016 as a Dorbz, Juggernaut is finally going to get his due as an unstoppable exclusive–it's the Walgreens Exclusive Funko Juggernaut POP Vinyls figure!Continue Reading →
Way back in summer 2016, Funko released their first-ever Iceman vinyl figure as part of a SDCC 2016 Exclusive Dorbz X-Men 3-Pack. Following that up, the Hot Topic exclusive Iceman Mystery Minis figure arrived at retail this winter (an appropriate season for Iceman to be released). We've been wondering since last summer when and where we'd finally get an official Funko Iceman POP Vinyl figure, but now we wait no more: the Specialty Series Iceman POP figure has now been announced!Continue Reading →
Some toy companies get a little bit quiet in the month before the New York Toy Fair (and yes, I'll be braving the bitter Manhattan winter again for you all next month), but Funko isn't one of those companies! In fact, they hit us up with a double whammy of Marvel POP Vinyls announcements today–including one pair of Jessica Jones figures that's not exactly "news" and a quartet of Netflix Daredevil Season 2 POPs now up for order that definitely are…Continue Reading →
Earlier today I discussed the nine new figures that will make up the first wave of Guardians of the Galaxy Vol. 2 Funko POP Vinyls at mass retail, but as usual, Funko's got a cavalcade of exclusives coming for us as well! Whereas the first GOTG movie had only one store exclusive when it launched, Funko is quintupling that number for Guardians of the Galaxy 2, with five exclusives including a Target Exclusive super-sized Baby Groot POP!Continue Reading →


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October 25 7:15 P.M.
Come early for Life Groups at 6:15 P.M.
Welcome Mitcham Family
to our Church Family and Community!
Michael & Ruth Mitcham are our new Youth Directors!
They have two sons, Timothy & Matthew!
|Rock Springs Baptist Church Prayer List
Connecting 4 Him Outreach -
Sunday School Connect Group
|Bobby & Jackie Osborne - Health
|Fall Fest - Outreach opportunities
|Kenny Harris - Kidney
|Molly Miller - Peace Corp - Ecuador
|Natural Disaster Victims - Mexico, Puerto Rico, Texas, Virgin Islands, Florida
|Traci Weaver - Surgery recovery
|Carria Woodburn - Kidney Cancer
|Ellen Dorris - Recovering from a stroke


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Good afternoon, my wife was extreemely satisfied with your Mineral Anti Wrinkle Cream as per our order 102829 dated 2011-11-15. Now she want to place a new order for three boxes.
Yair Emanuel Raw Silk Appliqued Challah Cover
Yair Emanuel's brightly pieced appliqu?-on-raw silk designs make a beautiful challah cover and are a colorful way to decorate your table for holidays and Shabbat.
Each of these challah covers has the words 'Shabbat V'Yom Tov' [Shabbat and Holidays] embroidered as an intricate part of the overall design. You may choose from any of these festive designs:+1-Pomegranate Mosaic: Five different pieces of material, each with a pomegranate motif – a pomegranate is a traditional symbol of fertility - are combined in a mosaic of colors.+6-Jerusalem Panorama: A skyline of Old City buildings sit atop the Jerusalem hills+9-Fish Blue: Pairs of fish, symbols of good luck and plenty, swim on a blue water background+15-Wheat, Blue: Stalks of wheat wave against a blue sky with grains blowing in the wind+23-Creation: symbols of each day of the seven days of creation in Genesis are featured in this colorful design+24-Birds, Gold: a pair of singing birds rest on a flowering tree branch+27-Seven Species: Each of the seven species of the Land of Israel – wheat, barley, grapes, figs, pomegranates, olives, and dates - is depicted in bright colors+35-Pomegranates: Bright red pomegranates of varied sizes are scattered around this cover+40-Lilies on Blue: Beautiful white lilies in full bloom stand out against a sky blue background.+Dimensions: 20 x 16 inch [50.8 X 40.6 cm]+


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Monday, September 3, 2012
An Engineer's Guide to Cats
Happy Labor Day, everybody! Ironically, I'm not feeling very motivated to put in the labor for a proper post, it being a holiday and all. Instead, I'm going to share one of my favorite internet videos of all time. I love "An Engineer's Guide to Cats" because I'm already on the fast-track to becoming a Crazy Cat Lady, but also because I know a few engineers, and they are their own breed, for sure. So enjoy this video, and then go out and enjoy the holiday. I'll be going to see Paranorman. How about you?
Posted by Maegan Langer at 12:12 PM
5 comments:
- William Kendall said...
What splendid timing today!
- September 3, 2012 at 12:26 PM
- Janiel Miller said...
My huz is an engineer, and he ain't nothin' like this. I think. In any case he is not a cat person. Not. He refers to small dogs, derisively, as cats.
Man. I just got a flashback of walking through the Clyde building to meet my then fiancé. I'm a little tripped out.
- September 3, 2012 at 5:46 PM
- Suzi said...
That was funny. I know a lot of stereotypical engineers like that, although I am not one. I'm also not a cat person. I learned a little about cats though--thanks. :)
- September 4, 2012 at 8:28 AM
- jjsundevil said...
kittys makes me hap hap happy
- September 5, 2012 at 5:18 PM
- Russo said...
I just love this video, I always laugh when watching it. I'm so glad you put it on out blog because you know I'm going to come back a lot to watch it. Plus, the cats are super cute too.
- October 1, 2012 at 3:55 PM
Subscribe to: Post Comments (Atom)


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Conceived and designed the experiments: AM. Performed the experiments: AM ETG ARP SDSB NMM DAFDO LRB CMT JB XW. Analyzed the data: AM ETG ARP SDSB AMM JDM PP OB WS. Contributed reagents/materials/analysis tools: ARP CMT VK PP WS. Wrote the paper: AM.
The authors have declared that no competing interests exist.
Extrathymic CD4+CD8+ double-positive (DP) T cells are increased in some pathophysiological conditions, including infectious diseases. In the murine model of Chagas disease, it has been shown that the protozoan parasite
The thymus is a primary lymphoid organ that plays an important role on the development of the immune system and maturation of the T cell repertoire. During the normal life span, this organ undergoes involution during the aging and also in the presence of a wide variety of infectious diseases. It has been shown that the protozoan parasite
Chagas disease is caused by the flagellate protozoan
In experimental models of Chagas disease, several alterations in lymphoid organs were observed, including the thymus where the parasite has been detected
During lymphocyte development, TCR gene assembly occurs by combinatorial linking of gene segments. The nature of this process gives rise to lymphocytes that can recognize self-antigens and have the potential to induce autoimmunity
Herein we attempted to clarify whether the changes in the thymic microenvironment, as a result of parasite infection, play a role on the modulation of the negative selection of thymocytes, a key element for the control of autoimmunity. To this end, we analyzed the intrathymic expression of Aire and TRAs as well as the expression of pro-apoptotic Bim protein during the course of the thymic
The study was approved by the Research Ethics Committee of National University of Rosario, (protocol UNR-CD 2854/2008) and Fiocruz (protocol CEUA-LW8/10). Protocols for animal and human studies were approved by the Institutional Ethical Committees in accordance with international guidelines. All animal experimentation was performed in accordance with the terms of the Brazilian guidelines for the animal welfare regulations. All individuals provided written informed consent.
Healthy volunteers and
Male BALB/c mice, aged 4–8 weeks, were obtained from the Oswaldo Cruz Foundation animal facilities. The OVA-TCR transgenic mice (BALB/c background, clone D011.10, that recognize the 323–339 peptide fragment of OVA in the context of I-Ad), were bred under standard conditions. Acute
Thymuses from normal and infected animals (after 2 weeks of acute infection) were fixed in neutral buffered formaldehyde or Bouin's solution and processed for paraffin wax sectioning. The 3–5 µm thick paraffin sections were stained with hematoxylin-eosin, impregnated with ammoniacal silver according to Weil–Davenport method or stained with Periodic acid-Schiff for demonstration of metallophilic macrophages, as described
Immunoperoxidase assays were performed using standard techniques on 4% formaldehyde-fixed frozen sections or chamber slides. Endogenous peroxidase was blocked with 3% H2O2. Non-specific protein binding was blocked by incubation with 5% normal swine serum. Sections were sequentially incubated with rabbit anti-mouse Aire polyclonal antibody for 60 min at 37°C, horseradish peroxidase (HRP) labeled swine anti-rabbit polyclonal antibody for 60 min at 37°C, with intervening phosphate buffer solution (PBS) washes. After a complete wash in PBS, the slides were developed in 0.05% freshly prepared 3,3′-diaminobenzedine solution with 0.03% hydrogen peroxide for 5 min, and then counterstained with hematoxylin, dehydrated, air-dried, and permanently mounted. For frozen sections, the optimum dilution of each antibody was first determined by serial dilutions on normal mouse thymus sections. Normal swine serum was used to substitute for the primary antibody to serve as a negative control. The stained cells were observed under a Bio-Rad MRC 1024ES regular microscope equipped with a Zeiss Diaphot inverted microscope (Jena, Germany). Rabbit anti-mouse Aire polyclonal antibody and HRP labeled swine anti-rabbit polyclonal antibody were purchased from Santa Cruz Biotechnology Inc. (California, USA).
Thymocytes were lysed at a concentration of 3×108 cells/ml in 0.2% Nonidet P-40 lysis buffer. Lysates were incubated on ice for 15 min, centrifuged at 16,000 x
RNA was isolated using TRIzol (Invitrogen, Life Technologies) and reverse-transcribed to cDNA using the SuperScript TM III Reverse Transcriptase (Invitrogen, Life Technologies). Real-time PCR was performed with the ABI Prism 7900HT Fast Real-Time PCR System instrument (Applied Biosystems) using the qPCR SYBR Green Core Kit (Eurogentec) according to the manufacturer's instructions, except that 2 mM MgCl2 concentration was used. The amplification program included an initial denaturation step at 95°C for 10 min, followed by denaturation at 95°C for 15 s, and annealing and extension at 60°C for 1 min, for 45 cycles. SYBR Green fluorescence was measured after each extension step, and the specificity of amplification was evaluated by melting curve analysis. Primers used to amplify specific gene products from murine cDNA were K5 sense, 5′-agtcaacatctccgtcgtcac-3′; K5 antisense, 5′-gggactgcctaaaagaagcag-3′; Aire 11/12, 5′-ccccgccggggaccaatctc-3′; Aire 12/13, 5′-agtcgtcccctaccttggcaagc-3′; Ins2 sense, 5′-gacccacaagtggcacaac-3′; Ins2 antisense, 5′-tctacaatgccacgcttctg-3′, Mup1 sense, 5′-tctgtgacgtatgatggattcaa-3′; Mup1 antisense, 5′-tctggttctcggccatagag-3′; Spt1 sense, 5′-aacttctggaactgctgattctg-3′; Spt1 antisense, 5′-gaggcctcattagcagtgttg-3′; IFN-γ sense, gaaagcctzgaaagtctgaataact; IFN-γ antisense, atcagcagcgactccttttccgct; GAPDH sense, gccgcctggagaaacctcccaagt; GAPDH antisense, tattcaagagagtagggagggctc. The relative gene expression levels were calculated using the comparative
Heparinized whole blood was collected and diluted 1/1 with PBS before separated by density centrifugation on Ficoll-Hypaque (Sigma) for 30 min at 2000 rpm. All antibodies were purchased from BD Biosciences (CA, USA). For human T cell phenotyping, individual samples contained 1.106 living cells were pre-blocked with human AB serum for 15 min and stained at 4°C for 30 min simultaneously with four colors using the following antibodies for FACS analysis: APC-labeled anti-CD3, APCCy7-labeled anti-CD4, PECy7-labeled anti-CD8 and FICT-labeled anti HLA-DR antibodies (BD/PharMingen). For murine T cell phenotyping experiments, thymuses and subcutaneous lymph nodes (pool of inguinal, axilary and brachial lymph nodes) were removed from infected and control animals. The organs were minced, washed and resuspended in PBS-FCS 5% for subsequent evaluation of cellularity, which was followed by triple or quadruple immunofluorescence staining, as previously described
CD4+CD8+ T cells were obtained from lymphoid tissues of normal and infected animals in the peak of parasitemia (2 weeks post-infection). The total number of CD4+CD8+ T cells was determined by FACS analysis. The purification of the DP subset was obtained by FACS cell sorting using anti CD3-FITC, anti CD4-PERCP, and anti CD8-PE. After FACS cell sorting, the total RNA from DP subset was extracted using standard Trizol extraction. mRNA transcripts for mouse IFN-γ were amplified using specific primers in quantitative RT-PCR as described
The mouse mastocytoma cell line, P-815, was labeled with CFSE based on the manufacturer's instructions (Molecular Probes) and used as target cells. The labeled cells were adjusted to 5×104 cells/mL, and 100 µL/well was plated in 96-well microtiter plates. CD4+CD8+ T cells obtained from lymphoid tissues of infected animals or normal single-positive CD4+ or CD8+ T cells as controls were added at different effector-target ratios. Plates were incubated in a humidified atmosphere of 5% CO2 and 37°C in the presence of anti-CD3 mAb at a concentration of 20 µg/ml for TCR triggered-redirected cytotoxicity activity. After 6 hours, the wells were harvested to allow quantitative analysis of the cell populations by FACS analysis. To stain for dead cells, propidium iodide (1 µg/mL) was added, and samples were mixed properly and directly analyzed by flow cytometry. The absolute number of surviving cells was determined at each time point by calculation of the acquisition of CFSE-lived cells at a fixed period of time. The absolute number of cells at the moment of T- cell addition (t = 0) is the number of target cells added to the wells (5,000). The percentage of survival was calculated as follows: % survival = [absolute no. viable CFSE+ target cells (t = x)]/[absolute no. viable CFSE+ target cells (t = 0)] x 100.
Results were expressed as mean ± standard error, unless otherwise indicated. Parametric and non parametric tests were used, depending on the characteristics of variables (normal distribution or not, etc). Comparisons among groups were made by parametric analysis of variance (k groups >2) followed by Student's t-test (k groups = 2) or non parametric Kruskall-Wallis test (k groups >2) followed by the U Mann-Whitney test (k groups = 2). Differences between control
The acute infection experimental model of
The histological profiles show the
As the macrophages represent a parasite reservoir in the thymus
Interestingly, in contrast to normal thymus (
Previous studies have demonstrated that TRAs are expressed in the thymus and this expression is needed for the deletion of self-reactive T cells. An important molecule in regulation of TRA expression by medullary TEC (mTEC) is Aire
To study the expression of self-antigens we chose three TRAs (Ins1, Mup1 and Spt1) that are downregulated in Aire deficient mice and follow the same expression pattern as the Aire gene. All three genes have highly selective, tissue-specific expression. For example, Ins1 encodes for insulin expressed by pancreatic beta cells, Spt1 is expressed in salivary and lacrimal glands, and Mup1 is expressed in the liver and also in salivary, lacrimal and mammary glands
The real-time PCR analysis showed similar levels of Aire expression in both normal and infected thymus (
In order to evaluate the checkpoints of the intrathymic thymocyte negative selection, we next assessed the proapoptotic Bim expression levels in DP thymocytes during
As the expression of Aire/TRA genes and the pro-apoptotic Bim protein were not changed in the thymus undergoing atrophy upon
We then evaluated whether the depletion of DP cells by co-administration of the cognate antigen is affected in the presence of thymus atrophy during
OVA-TCR transgenic mice noninfected or infected with
Since all our findings suggested that negative selection in
Mice were infected with
Moreover, analysis of thymocytes for the expression of L-selectin (CD62L), an up-regulated marker of recent thymic emigrant and mature T cell subsets, indicated that DP cells obtained from acutely chagasic animals express high levels of this molecule, as compared to corresponding controls (
To further compare the differentiation of DP cells with activated cells, we determined the changes in level of IFN-γ transcripts after
To further study the differentiation status of DP cells, we tested whether this particular T cell subset had cytotoxic activity. To address this issue, DP cells were purified by cell sorting from chagasic peripheral lymph nodes at day 15 post-infection and varying numbers of sorted DP cells were incubated with P815 target cells. The effector:target (E:T) ratio was normalized based upon the frequency of T cells in order to compare the cytolytic activity on a per cell basis. Anti-CD3 mAb-redirected cytotoxic activity was measured because specific antigens for DP cells are unknown at present. In contrast to naïve CD4+ and CD8+ T cells, DP cells showed significant cytotoxic activity (
We further compared the cytotoxic activity of DP cells and activated CD8+ T cells obtained from peripheral lymphoid tissues at day 15 after
In the light of evidence that the DP cells released into the periphery acquire an activated phenotype similar to what is described for activated effector or memory single-positive T cells, we next evaluated a possible relationship between the presence of these cells and the development of severe clinical forms of human Chagas disease. For this purpose, we first examined the frequency of peripheral blood DP cell subset in cross-sectional studies of chronic chagasic patients at the indeterminate or cardiac clinical forms of Chagas disease. The results show higher percentage of DP cells from peripheral blood of cardiac chagasic patients as compared to noninfected individuals. However, this statistically significant increase was not seen in the percentages of DP cells from peripheral blood of patients at the indeterminate stage of chonic disease, when compared to control individuals (
Peripheral whole blood from non-infected individuals (NI), patients at the indeterminate (IND) and cardiac (CARD) forms of Chagas disease were analyzed by four-color flow cytometry for expression of CD3, CD4, CD8, HLA-DR and VLA-4 markers (n = 15 individuals per group).
Moreover, we showed a statistically significant increase in the activation profile of extrathymic activated DP cells in cardiac chagasic patients to assess the expression of activation marker HLA-DR indicated that peripheral blood subset of DP cells obtained from chronic cardiac chagasic patients (but not from patients at the indeterminate form of the disease) highly express significant levels of this molecule, as compared to normal individuals (
Additionally, phenotype FACS analysis of the expression marker VLA-4 indicated that the peripheral blood subset of DP cells from both indeterminate and cardiac chronic patients express highed levels of this molecule as compared to normal individuals (
Several pathogens, including
Nevertheless, it was not determined if the changes of the thymic microenvironment seen following
It is largely established that interactions between TEC and thymocytes control the development of the thymic microenvironment and T cell development. Previous studies have shown that the disruption of normal thymic architecture is known to affect the expression pattern of autoantigens by TEC and functionality of thymus
As the acute phase of infection progresses, the thymic atrophy becomes evident, as is the increase in numbers of apoptotic intrathymic DP cells, compared to their respective normal counterparts
Although the intrathymic checkpoints necessary to avoid the maturation of T cells expressing a forbidden T cell receptor repertoire are present in the acute phase of murine Chagas disease, it has been shown that DP cells are early released from infected thymus to the periphery
Interestingly, despite the expansion of peripheral DP lymphocytes in the experimental model of Chagas disease, these cells develop an activated phenotype, upregulating the activation markers CD44 and CD69, tightly linked to the differentiation status of T cells. In addition, we showed that highly purified (>98%) DP cell populations from infected mice obtained after cell sorting, produced high levels of IFN-γ mRNA. Furthermore, similar to previous studies showing high cytotoxic activity and effector memory phenotype of extrathymic DP cells in
All together, our results indicate a role of the DP T cell subset in the inflammatory process caused by parasite-driven immune responses. It is possible that co-expression of CD4 and CD8 molecules on the T cell membrane would enhance the avidity of the TCR to its target cell. In this way, the concomitant trigger of CD4 and CD8 co-receptors through MHC-antigen complex would reduce the threshold of the antigen signal and decrease the requirements for the costimulatory signals to generate T cell activation
In conclusion, our data indicate that the key intrathymic checkpoints necessary to promote negative selection process of thymocytes are effective during acute chagasic thymic atrophy. Although the negative selection process is still functional in the acute phase, DP cells are prematurely released to the periphery. During the course of experimental infection, these peripheral DP cells acquire an activated phenotype similar to what is described for activated and memory single-positive T cells with high IFN-γ production, CD44+CD69+ expression and cytotoxic activity. This is particularly important, as we show for the first time that the appearance of full activated peripheral DP cells correlate with the cardiac clinical form of human chronic Chagas disease. Most likely, the presence of peripheral, mature and activated DP lymphocytes challenges the perception of the T cell populations involved in adaptive immune responses during the
We thank the staff of Chagas Section of Cardiology Unit from Hospital Provincial del Centenario.


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More than 1,400 people will take part in the Walk to Defeat ALS on Saturday, March 18th at 11 a.m. at Lake Eola. The Walk to Defeat ALS is open to anyone who wants to join in the effort to raise money for patient services, programs and ALS research. ALS, also known as Lou Gehrig's Disease, has no known cure, but the ALS Association hopes to change that.
Suehay Echeverry talked about the Walk to Defeat ALS on SUNNY Across Central Florida .


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Kuvauen badested Swimming Spots
Essential info
- January – December
- Easy
- 2.9 kilometers
- 0 meters
- – 2 hours
About Kuvauen badested
Kuvauen is a narrow inlet into the mainland with several small sandy beaches and is well protected from the wind. It is idyllic and ideal for swimming, sunbathing, beach life, tenting, fishing, bouldering and boating. The area is very child-friendly and easy to keep an overview over with long and flat beaches. You can walk all the way down with a stroller.


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Cannes festival- who haven't heard the name of this festival and the place where it takes place? But have you ever thought to go there on your honeymoon? Then think about it now! What will you get there? Let's find the magic of Cannes and plan something new for this the most popular tourist destinations in the world. The most ... Read More »
Why Alentejo is the Most Beautiful Places in the World for Honeymoon
Want to make your honeymoon a little bit classier and mixed with history? Then Alentejo of Portugal can be our dream destination for the most special day of your life. The Most Beautiful Places in the World for Honeymoon, Alentejo consist of a huge area, stretching south from the Rio Tejo to the northern mountain ranges of the Algarve. It ... Read More »
Why Amsterdam Is The Romantic Honeymoon Destination
Beauty and the flavor of ancient time- want to enjoy both of them on your honeymoon? Then the Romantic Honeymoon Destination, Amsterdam can be the very first choice of you. Yeap, Amsterdam, the most popular tourist destination of the world is much known to all. But have you ever thought how much exciting it can make your honeymoon? No? Then ... Read More »
How To Make Your Spain best all inclusive honeymoon destinations Look Amazing
If you have not decided yet about your honeymoon destinations, you can read this article. In this article, I will introduce you with another best all inclusive honeymoon destinations in the world. That is Spain, a country on Europe's Iberian Peninsula, includes 17 autonomous regions with diverse geography and cultures. The astonishing architectural heritage and the spell bounded portrait like ... Read More »
Ibiza in Spain why most beautiful places in the world for honeymoon
Nothing can beat an Island in the Mediterranean when it comes to honeymoon destinations. The comforting sunlight, refreshing sand, tastiest cuisine, the exotic sea wave, classy resorts with all kinds of comfort available certainly take you away from all kinds of hustle and bustle of everyday life that you do not want at all in your romantic honeymoon. After all, ... Read More »


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Hi, I am looking into getting a WR450 or a YZ426. I plan to ride mainly in the woods and some beach tracks. Im trying to save a bit of $ by getting the YZ instead of the the WR. I dont mind not having the e-button. My main concern is the gearing. Does anyone have the gear ratios for the two bikes? I mainly need the primary ratio and the gearbox ratios. The sprockets are easily changed so i dont really mind if I have to do those.
WR450 vs YZ426 gearing
Wow, you want to get specific
I refered to my 1998-2002 yz/wr 4xxf Clymer manual for the specs your seeking. It might not be correct for the 450, but should give you an idea of the differences between the yz and wr.
Primary reduction/gear....................2.952(62/21) (yz and wr are the same)
secondary reduction/chain
Gear Ratios
these numbers change slightly from year to year but you can get a picture of whats going on. The WR's wide ratio transmission actually starts with a lower first gear and ends with a higher 5th gear.
On my WR- 1st, 2nd, and 3rd gears are wicked and will cause you to hold on trying to counter the gforce of acceleration(and the front end when the back tire hooks up). 4th gear finally will allow you to relax slightly although you are now going very fast.
I think you can use either bike for about anything, and can change your secondary ratio to meet your needs
Wow, thanks Numskull
This helps me a lot. I think i may go for the WR afterall because I can gear down the YZ to get the trque at low speeds but then I will be changing gears every 2 sec and my top speed will not be that great. Plus I get the magic button with the WR450
Thanks again
You also get at least 30lb more weight with the WR.
I have thrown a leg over a yz only once, but there is not doubt it feels lighter.
Excellent choice either way...
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Sep 13, 2005
|Filing date
|May 11, 2001
|Priority date
|May 11, 2001
|Fee status
|Also published as
|Publication number
|David G. Quinn
|Original Assignee
|Radius International Limited Partnership
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (51), Referenced by (16), Classifications (7), Legal Events (6)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates in general to medical catheters. It relates, more particularly, to blood vessel catheters.
Blood vessel catheters are normally either venous catheters or arterial catheters. Venous catheters, in turn, usually come in several forms. The simplest are short peripheral catheters. Hemodialysis catheters comprise one form of central venous catheter and are normally placed in the superior vena cava.
Blood vessel catheters of almost all types are pliable so that they do not damage body tissue when they are in-situ. Pliability can create a problem during insertion, however, because the catheters can kink when they meet resistance. Thus, there is often a need for a certain amount of stiffness so that the catheters can be directed within body vessels or cavities. There are currently two methods of providing this stiffness; stylets and guide wires.
A stylet can be a single or a twisted wire with a blunt end that is inserted into the catheter to make it stiff. The stylet is often used with bullet nose catheters and maintains its position within the catheter as the catheter is inserted. The stiffened catheter is advanced into the blood vessel with the stylet.
In contrast, guide wires are used to both stiffen the catheter and to provide a guide for the insertion. Commonly, the guide wire is inserted into the blood vessel before the catheter. The catheter is then inserted into the blood vessel over the wire, and follows the wire as it travels inside the vessel. Guide wires are most often utilized with catheters that are inserted deep into the body, such as with central venous catheters that are inserted into the heart. The thin guide wire more easily makes the bends and turns necessary for this type of placement.
In guide wire insertion where the catheter must be inserted over the guide wire, catheters with open ends are normally utilized to permit passage of the guide wire. These catheters are more likely to cause damage to body tissue during insertion than bullet nose catheters, for example, because of their flat ends and side edges. Open ended catheters are also more likely to damage tissue than bullet nose catheters while in-situ. Nevertheless, the need for deep catheter insertion has heretofore made guide wire insertion of open-ended catheters the accepted procedure in spite of the disadvantage of their flat or blunt end design.
As an alternative, bullet nose catheters have been used with guide wires in some applications by incorporating a small hole through the nose for the wire to pass through. This approach has generally been found undesirable, however, because the hole in the bullet nose can later collect particulate matter and be a focal point for infection.
An object of the present invention is to provide an improved catheter for use with a guidewire.
Another object of the invention is to provide an improved bullet nose bolus for use on catheters ranging in size from 3 French to 22 French in any medical application.
Still another object is to provide a bullet nose bolus for a catheter which is compatible with a guide wire yet does not require an axially extending hole through the nose.
A further object is to provide a bullet nose for a bolus that protects the leading edge of the catheter outflow or inflow port from rubbing against the vessel wall.
Another object is to provide a bullet nose bolus for a catheter that will not kink during insertion.
Another object is to provide a bullet nose bolus for a catheter that can be inserted simultaneously with a guide wire through a flexible introducer sheath that is essentially the same size as the catheter itself.
Another object is to provide a bullet nose bolus for a catheter that follows a guide wire through bends in a patent's vein and turns without causing increased resistance to passage through the vein.
Another object is to provide a bullet nose bolus that always presents a rounded surface to the vein wall, even when the catheter is bending.
Another object is to provide a bolus with a nose which is flexed by the guide wire in only one direction.
The foregoing and other objects are realized in accord with the present invention by providing a blood vessel catheter that combines a single lumen tube and a bolus with a bullet nose. The bolus has an axially elongated side port behind the bullet nose. The bolus is molded of resilient plastic and includes a connector section at its rear end fastened to the distal end of a catheter tube, a nose section with a bullet nose at its front end and a passage section between them. The passage section contains an axially extending passage which communicates with the tube lumen at one end and opens over the base of a radially oriented port at the other end. A longitudinally elongated stiffening arch is formed in the bottom of the bolus passage section, opposite the port.
From approximately the mid-point of the axially elongated port, where the stiffening arch is thickest, the outer surface of the passage section opposite the port begins to curve toward the longitudinal axis of the bolus. At the same point, the opposite side surfaces of the passage section which bracket the port and the arch curve inwardly toward the axis.
The passage section forward of the mid-point of the port, and the nose section, are effectively inclined toward the longitudinal axis of the bolus and the tube. The passage section joins the nose section of the bolus at the forwardmost end of the side port on a transverse plane where the nose section is at a maximum thickness in a direction passing through the bolus axis and the center of the port. The plane is inclined rearwardly toward the port at an angle corresponding to the effective angle of incline of the curving passage section toward the bolus axis. The thickness of the nose section in this plane in the direction of the bolus axis and the port is 25% to 30% less than the outside diameter of the catheter tube.
The nose section of the bolus is thus offset radially to the port side of the longitudinal axis of the bolus. This displacement results in a bolus configuration wherein a portion of the outermost periphery of the nose section is tangent to an imaginary cylinder containing the outer surface of the bolus passage section. This offset nose configuration serves to prevent the trailing edge of the port from abrading the vein wall.
During insertion of the catheter into a patent's vein, however, the offset nose configuration serves another purpose. When a guide wire is passed through the bolus, the nose section flexes toward the longitudinal axis of the bolus to permit the wire to pass without forcing the nose section outside the larger tube profile, i.e., outside the imaginary cylinder in which the outer surface of the passage section lies. This makes insertion of the catheter much easier.
Referring now to the drawings, and particularly to
The 10.5 French catheter tube 11 has a distal end 15. Its proximal end, not shown, will have a conventional connector (not shown) fastened to it. The catheter tube 11 has a bolus 20 fastened to its distal end 15.
Referring additionally to
The distal end 15 of the tube 11 joins the bolus 20 at 31. Forward of the line 31, the tube body 24 has a necked down end 33 which is seated in a suitably formed socket 34 in the bolus 20 and glued or otherwise fastened to the bolus 20. When silicone is used, the components may be welded together for the curing operation.
The bolus 20 comprises a generally cylindrical body 51 molded from silicone. The dimensions of the body 51 vary with the size of the catheter tube 11 in use, but with the 10.5 French tube which is shown here, the body 51 has an O.D. of 0.136 inches. The bolus body 51 comprises a tube connector section 55, a flow passage section 56 and a nose section 57.
The necked down end 33 of the tube body 24 is seated in the socket 34 formed in the connector section 55 of the bolus body 51. The lumen 27 in the tube body 24 communicates with one end of an axially extending passage 66 in the passage section 56 of the bolus body 51. The other end of the axially extending passage 66 opens over a base 68 under a radially oriented port 69. The base 68 curves across the axis X of the bolus body 51 to form the front end of the port 69 opening through the side of the bolus 20.
The port 69 extends around in the passage section 56 to its sides 71, which are low enough to make the port extend circumferentially around about 190� of the body 51, as seen in FIG. 6. The trailing edge 72 of the port 69 is rounded, as seen in
Directly opposite the port 69, the passage section 56 below the base 68 is formed outwardly, as at 73, to create a stiffening arch in the bolus body 51. The arch 73 begins opposite the trailing edge 72 of the port, increases in thickness until it is directly under the mid-point of the port 69, and then decreases in thickness toward the nose section 57.
This configuration results in a bolus body 51 wherein the effective axis Y of the passage section 56 in front of the mid-point of the port 69 and the nose section 57 in front of this portion of the passage section is inclined at an angle of 22� to the axis X of the bolus body. The center of the nose section 57 is then offset from the axis X in the radial direction of the port 69.
As best seen in
The nose section 57 has a slightly elliptical shape in cross-section on the plane P where it joins the passage section 56, as seen in FIG. 5. The aforedescribed configuration produces a maximum thickness of the nose section 57, in the direction of the port 69 and in the plane P which is 29% smaller than the outside diameter of the catheter tube 11. At the same time, as seen in
Referring now to
When the catheter 10 is being inserted through a patient's vascular system toward its operational position, it must initially make its way through smaller diameter veins. As seen in
When it is necessary for the bolus 20 and its trailing tube 11 to follow a vein V around turns, the wire W moves off center to one side of the nose section 57, as seen in
Turning now to
The present invention provides the physician with a bullet nose catheter 10 which can be inserted using a guide wire W but which does not require perforation of the bolus nose to facilitate passage of the guide wire. The nose section 57 of the bolus 20 flexes to permit passage of the wire W but, in doing so, does not protrude outside the imaginary cylinder defined by the rest of the bolus and the catheter tube 11, whereby pressure of the bolus on vein V wall is not increased. Nevertheless, with the catheter 10 in operational position in a patient's vein and the wire W removed, the nose section 57 returns to its normal position wherein it prevents the vein wall from wrapping around the bolus port edge 72 and becoming abraded thereby.
While a preferred embodiment of the invention has been described, it should be understood that the invention is not so limited and modifications may be made without departing from the invention. The scope of the invention is defined by the appended claims, and all devices that come within the meaning of the claims, either literally or by equivalence, are intended to be embraced therein.
|Cited Patent
|Filing date
|Publication date
|Apr 7, 1931
|Sep 27, 1932
|Honsaker Charles Coy
|Colonic tube
|Jun 14, 1935
|May 3, 1938
|Rusch Willy
|Rubber tube for medical use
|Mar 11, 1966
|May 21, 1968
|Shriner Walter
|Surgical wound drain having an inner collapsible tube preventing reverse flow into the wound
|Feb 7, 1969
|Jun 29, 1971
|David S Sheridan
|Postsurgical tubes with capped proximal end
|Jan 26, 1976
|Jul 26, 1977
|Raulerson James D
|Continuous flow catheter device
|Jul 5, 1977
|Jan 16, 1979
|Mahurkar Sakharam D
|Double lumen hemodialysis catheter
|Oct 2, 1979
|Jun 2, 1981
|Plumley Peter F
|Gastro-intestinal tubes
|Jun 4, 1979
|Jan 19, 1982
|Henry Bridgman
|Vacuum curet having an improved curetting opening
|Jul 7, 1980
|Jan 18, 1983
|Purdue Research Foundation
|Implantable catheter
|May 4, 1981
|Apr 26, 1983
|Somers 3Rd Lewis S
|Enteral feeding apparatus and method
|May 28, 1982
|May 1, 1984
|Ekbladh Fred V G
|Catheter for postsurgical drainage
|Feb 23, 1983
|Feb 12, 1985
|Purdue Research Foundation
|Catheter guide
|May 3, 1983
|Jul 16, 1985
|Catheter Technology Corporation
|Method and apparatus for placing a catheter
|May 3, 1983
|Oct 29, 1985
|Catheter Technology Corporation
|Valved two-way catheter
|Dec 5, 1983
|Dec 17, 1985
|Purdue Research Foundation
|Permanently placed transcutaneous access device to blood vessels
|Oct 1, 1984
|Feb 4, 1986
|Mahurkar Sakharam D
|Double lumen catheter
|Aug 15, 1984
|Apr 22, 1986
|Mahurkar Sakharam D
|Smooth bore double lumen catheter
|Feb 12, 1985
|Nov 18, 1986
|Mahurkar Sakharam D
|Method and apparatus for using dual-lumen catheters for extracorporeal treatment
|Apr 5, 1985
|Jan 27, 1987
|Research Medical, Inc.
|Venous return catheter
|Oct 25, 1985
|Jun 9, 1987
|Catheter Technology Corp.
|Valved two-way catheter
|Jan 29, 1986
|Sep 8, 1987
|Mahurkar Sakharam D
|Double lumen catheter
|Apr 3, 1986
|Sep 8, 1987
|Berlin Richard B
|Surgical wound drain device
|Oct 2, 1986
|Oct 20, 1987
|Catheter Technology Corp.
|Valved two-way catheter
|Jul 18, 1986
|Sep 13, 1988
|Mahurkar Sakharam D
|Method and apparatus for using dual-lumen catheters for extracorporeal treatment
|May 4, 1987
|Sep 20, 1988
|Catheter Technology Corp.
|Catheter dilator/sheath assembly and method
|Mar 4, 1987
|Nov 1, 1988
|Imtec S.A.
|Surgical drain
|Sep 16, 1987
|Feb 28, 1989
|Mahurkar Sakharam D
|Simple double lumen catheter
|Apr 19, 1988
|Jun 27, 1989
|Mahurkar Sakharam D
|Method and apparatus for using dual-lumen catheters for extracorporeal treatment
|May 16, 1988
|Jan 23, 1990
|Mahurkar Sakharam D
|Dual-lumen catheter-connecting system
|Jun 13, 1988
|Feb 6, 1990
|Claber S.P.A.
|Vascular access device, in particular for purification treatments of the blood
|Aug 24, 1990
|Oct 1, 1991
|Medical Components, Inc.
|Catheter having two coaxial lumens
|Feb 27, 1986
|Mar 30, 1993
|Mahurkar Sakharam D
|Simple double lumen catheter
|Oct 16, 1991
|Jun 22, 1993
|Mahurkar Sakharam D
|Reinforced multiple lumen catheter
|Feb 10, 1992
|Jun 22, 1993
|Mahurkar Sakharam D
|Multiple-lumen catheter
|Mar 13, 1992
|Dec 14, 1993
|Rochester Medical Corporation
|Microcidal agent releasing catheter with balloon
|Feb 17, 1993
|Jun 21, 1994
|Ash Medical Systems, Inc.
|Foldable catheter for peritoneal dialysis
|Apr 29, 1993
|Aug 9, 1994
|Marcus William Y
|Integral penetrating surgical drain device
|Apr 28, 1993
|Dec 20, 1994
|Mahurkar; Sakharam D.
|Reinforced multiple-lumen catheter and apparatus and method for making the same
|Nov 1, 1993
|Jan 3, 1995
|Mahurkar; Sakharam D.
|Triple-lumen critical care catheter
|Mar 24, 1994
|Sep 19, 1995
|Radius International Limited Partnership
|Non-occluding catheter bolus
|Oct 1, 1993
|Jan 23, 1996
|Mahurkar; Sakharam D.
|Multiple-lumen catheter
|Sep 21, 1994
|Nov 5, 1996
|Cruz; Cosme
|Multiple-lumen catheter
|Sep 18, 1995
|Feb 4, 1997
|Radius International Limited
|Non-occluding catheter bolus
|May 9, 1994
|Mar 4, 1997
|Decker; Rand A.
|Surgical insertion device and method
|Feb 23, 1996
|Apr 29, 1997
|Medical Components, Inc.
|Method for inserting a multiple catheter assembly
|Jun 7, 1995
|Nov 11, 1997
|Allegiance Corporation
|Continuous curve yankauer
|Nov 7, 1996
|Jul 7, 1998
|Medical Components, Inc.
|Multiple catheter assembly
|Aug 6, 1997
|Sep 7, 1999
|Hemocleanse, Inc.
|Splittable multiple catheter assembly and methods of inserting the same
|Jun 3, 1996
|Nov 16, 1999
|Michiel S. Kritzinger
|Corneal aspiration cannula and method of using
|Jul 12, 2000
|Jan 28, 2003
|Corpak, Inc.
|Bolus for non-occluding high flow enteral feeding tube
|May 11, 2001
|Feb 28, 2002
|Radius International Limited Partnership
|Hemodialysis catheter
|Citing Patent
|Filing date
|Publication date
|Apr 17, 2012
|Jun 4, 2013
|Covidien Lp
|Low profile catheter assembly
|Aug 27, 2010
|Dec 3, 2013
|Covidien Lp
|Valved catheter
|Sep 30, 2011
|Jun 10, 2014
|Covidien Lp
|Hemodialysis catheter with improved side opening design
|May 8, 2009
|Oct 21, 2014
|Covidien Lp
|Catheter with valve
|Mar 6, 2012
|Mar 24, 2015
|Covidien Lp
|Catheter with valve
|Sep 26, 2008
|Apr 14, 2015
|Covidien Lp
|Valved hemodialysis catheter
|Jan 10, 2013
|Jun 2, 2015
|Covidien Lp
|Catheter with valve
|Sep 30, 2011
|Jul 7, 2015
|Covidien Lp
|Catheter with external flow channel
|Sep 28, 2012
|Oct 13, 2015
|Covidien Lp
|Symmetrical tip acute catheter
|Sep 29, 2006
|Oct 27, 2015
|Covidien Lp
|Acute hemodialysis catheter assembly
|Sep 14, 2015
|Dec 27, 2016
|Covidien Lp
|Symmetrical tip acute catheter
|Mar 20, 2015
|May 9, 2017
|Covidien Lp
|Valved hemodialysis catheter
|Dec 22, 2011
|May 23, 2017
|Cook Medical Technologies Llc
|Multi-split-tipped catheter
|Apr 2, 2013
|Jul 25, 2017
|Covidien Lp
|Low profile catheter assembly
|Feb 22, 2005
|Aug 24, 2006
|Schneiter James A
|High flow diffusion catheter
|Oct 3, 2007
|Apr 9, 2009
|Tyco Healthcare Group Lp
|Bolus tube assembly
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|May 11, 2001
Owner name: RADIUS INTERNATIONAL LIMITED PARTNERSHIP, ILLINOIS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:QUINN, DAVID G.;REEL/FRAME:011805/0731
Effective date: 20010511
|Mar 10, 2009
|Fee payment
Year of fee payment: 4
|Apr 26, 2013
|Maintenance fee reminder mailed
|Sep 3, 2013
|Surcharge for late payment
Year of fee payment: 7
|Sep 3, 2013
|Fee payment
Year of fee payment: 8
|Apr 21, 2017
|Maintenance fee reminder mailed


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DALLAS – The Latest on a white former Texas police officer indicted on a murder charge in the April shooting death of a black teenager (all times local):
4:50 p.m.
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text:
On the bus home tonight, a thought popped into my head. It flitted in and out pretty quickly, but it was definitely there.
"What if Starling Marte homers in his first at-bat?"
I didn't really have an answer, and I pushed the thought out pretty quickly. I always ask that when a player makes a debut, because it's such a cool thing to have a player homer in his first at-bat. It came back, though.
"Really, what if he homers? It's in Houston and Dallas Keuchel is a lefty and he's pretty bad and the Crawford Boxes are there and I dunno, it just kind of feels right, doesn't it?"
I got home and mostly put the thought out of my mind, though I was kind of restless in the leadup to 8:05. Around 7:40, I had a brief internet blip and was afraid I was going to have to hop in my car and drive to lab for Marte's debut. Things got straightened out, though, and I got the game on in time and it turns out that it's a good thing that I did, because Marte took Keuchel's first pitch and absolutely hammered it to left-center for the ultimate in lead-off home runs.
I can't even fathom how awesome it must be for someone like Starling Marte to hit a home run on the first pitch of his big league career; as I mentioned earlier today he started out as not even being signed in his first year of eligibility in the Dominican Republic and his career in America started late and was slowed down by an injury and suddenly he's in a big league uniform in the middle of a pennant race, living out all of his wildest dreams and at the culmination of that very moment, he hits a home run. I get chills just thinking about what it must've been like in his shoes tonight.
What I can tell you is this: just seeing it happen was an incredibly rewarding moment for me as a Pirate fan. Grant Brisbee wrote a great piece at SB Nation today about how Marte being called up is such a very different thing for Pirate fans because he's a reinforcement and not a dream ticket and it's all very true. In the past, when players like Andrew McCutchen or Pedro Alvarez made their debuts for the Pirates, their first games were big events because we as Pirate fans needed big events so that we could break free from being Pirate fans. We're all in a different place now; we know things are changing in Pittsburgh and Marte represents a different kind of hope. It's different because unlike the hope that McCutchen and Alvarez represented, this hope is tangible. If Starling Marte comes up and does in Pittsburgh what he's been doing in Indianapolis since June, the Pirates' lineup is could be an absolute force to be reckoned with down the stretch and for a team that's already leading the wild card and within striking distance in the NL Central, that makes anything possible.
And so here this kid is, standing in the box with every minute of his life leading up to that very moment and all of Pittsburgh hanging on his at-bat because we all want to believe in this baseball team, and he hits a home run. I don't know what will happen with the Pirates over the rest of this season and I don't know how Starling Marte's career is going to play out from this point on, but I do know that his home run tonight is one of those moments of absolute magic that only baseball can produce and that nothing is taking that away from any of us.
After the first pitch, it was all a relatively straightforward Pirate win. Garrett Jones and Clint Barmes hit two run homers, AJ Burnett mostly cruised except for a rough spot in the eight inning when he served up two solo homers, and Joel Hanrahan closed out a roller-coaster save.
The Pirates are 14 games above .500. Sometimes, I just want to throw my hands up run around and yell, "It's all happening!" After nights like tonight, I can't help but think that it really might be.
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Toy with Raquel Sultra
XBIZ Berlin Schedule
Savana Styles Available
ChargeSavvy at ED Show
Driller Signs The Rub
NightMoves Calls for Sponsors
Casting Call
ABK Beta Users Free
OC Signs Darcie Dolce
Brittany is Back
Dollie Darko with 101 Modeling
Mercy West Available
The V Agency Joins LATATA
Sin Claire with Foxxx
New Smash VP Wyatt Case
Epoch Club Special Event
Ink Inks OC, The Rub
XBIZ 2016 Announced
RAW Signs Sasha Bradshaw
Direct Reps Harper
SashaBrabuster's XXX Comeback
AJ Applegate Available
Freedom Acres Open House
AINews New Look