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Oviedo Lodge was chartered in 1917 and many of Oviedo's leaders have been among our membership. Today, we are still actively involved in the community doing free Child ID Events, road clean-ups, toy drives, etc. The lodge's website address is www.oviedolodge.org and you can visit us on Thursday evenings between 7 and 9 pm.
Oviedo Lodge - 534 King St, Oviedo FL
(321) 765-7318
City of Oviedo, Florida • 400 Alexandria Blvd. • Oviedo, FL 32765 • Phone: (407) 971-5550 • Webmaster •
Please Note: Under Florida law, e-mail addresses are public records. If you do not want your e-mail address released in response to a public records request, do not send electronic mail to the City of Oviedo. Instead contact the City of Oviedo by phone or in writing.


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Image 1 of 1
Montana Governor Brian Schweitzer Crow Native Days AR610627_048_3.jpg
Brian Schweitzer, Montana Governor and John Bohlinger, Lieutenant Governor and Crow Dignitaries at Native Days ceremony for war veterans on Crow Indian Reservation, Montana. Army helicopters fly overhead.
- Copyright
- ©2008 Allen Russell. All rights reserved
- Image Size
- 3501x5230 / 8.6MB
- Contained in galleries
- Montana, Native Americans-Indians, Celebrities - Noted People

subset: commoncrawl


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When Seychelles Minister of Tourism and Culture Alain St.Ange addressed the opening ceremony of a new restaurant, he spoke about the need for Seychelles to see more stand-alone facilities where Seychellois and tourists can enjoy good food and an island atmosphere.
Aron Rose and his brother, Jacky N'Diaye, have come together to open the Carambole Restaurant, Bar & Lounge at the Angel Bayside Marina at Roche Caiman. The two Seychellois businessmen recently returned to Seychelles accompanied by their younger sister, Chanella Rose, who is now the Marketing Manager for the business that officially opened its door last Friday, February 5.
Present at the Official Opening Ceremony was Minister Alain St.Ange, the Seychelles Minister responsible for Tourism and Culture; Sherin Naiken, the CEO of the Tourism Board; Captain David Savy, the Chairman of the Seychelles Civil Aviation Authority; Achim Leiss, and the Managing Director of Angel Fish Bayside Marina, among many supporters of the new venture.
Aron Rose and his brother, Jacky N'Diaye, were instrumental some two years ago for bringing the group Kassav to perform at the Kreol Festival. It was Aron Rose who welcomed everyone at the opening ceremony of the new Carambole Restaurant, Bar & Lounge and gave a brief on what makes this new facility different to what exists. "Today we are welcoming back to our shores two Seychellois businessmen, and we are wishing them success in their new venture. We know that such a facility was a needed facility if we really want to see the yield from our tourism industry grow. Tourists need places to go out and enjoy themselves, and the new Carambole is a welcomed addition to existing establishments," said Minister St.Ange to the owners of the new restaurant, bar and lounge.
Seychelles is a founding member of the International Coalition of Tourism Partners (ICTP) . For more information on Seychelles Minister of Tourism and Culture Alain St.Ange, click here.


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- Worldwide Rank #86,038,317
- Follower/Following Ratio 0.16
- Daily New Followers 0
Joseph Rydell Tettey Twitter Stats
@0200906n - Tracking Joseph Rydell Tettey Twitter profile since December 31, 2013
Joseph is a corporate lawyer. He holds master degrees in law, management and commerce .
Cape Town, South Africa
Joseph Rydell Tettey's story
Joseph Rydell Tettey, also known as @0200906n has a reasonably significant presence on Twitter and is ranked by us in the 30% percentile for account strength. Active on Twitter since April 2009, Joseph Rydell Tettey made it to having a respectable 113 Twitter followers and to being ranked 86,038,317 for number of followers among all Twitter users.
Uh-oh... seems like someone has fallen asleep while on duty and is dropping in social relevance. The plot thickens when considering Joseph Rydell Tettey's follower-to-following ratio, which is 0.16. This actually doesn't reflect so well on this account's strength.
From a tweeting perspective, @0200906n is a casual user, with an average of 0 tweet(s) per day in the past 30 days. That's pretty consistent with a total of 79 since @0200906n joined Twitter.
This account is tracked by us Only December 2013. As of October 18 2017 we track 281928966 Twitter accounts, so feel free to search for other accounts you're interested in and reveal their Twitter story!
Joseph Rydell Tettey Tweets
@0200906n has posted 0 tweets in the last 10 days, which translates to an average of 0 tweets per day.
Joseph Rydell Tettey Twitter Followers
@0200906n has 113 followers on Twitter.
This account is #86,038,317 in the worldwide rank of the most popular Twitter users.
Joseph Rydell Tettey Following on Twitter
@0200906n is following 688 Twitter accounts.
Last month this account followed 124 users.
Joseph Rydell Tettey Predictions & Milestones
@0200906n will hit 113 followers in the next 3 months, and 113 in one year.
You are on Joseph Rydell Tettey's Twitter stats page
We track these Twitter stats since December 31, 2013 . You can see how many followers Joseph Rydell Tettey lost or gained and what the prediction is for tomorrow or the next 15 days, together with all kinds of other stats like rank compared to all Twitter users, tweets etc.
Why don't you give it a try and compare Joseph Rydell Tettey to yourself ? Or if you are Joseph Rydell Tettey get even more feature rich & up-to-date stats with our premium Twitter Stats.
Twitter Counter is the #1 Twitter stats site powered by Twitter. It all started in June 12, 2008 and we grew rather rapidly because of our Twitter Counter badge. The button is a nice small image that shows your visitors how many followers you have on Twitter. Within a year the button was on many many blogs around the world and we displayed more than 100 million buttons in one month. We track follower stats for over 281.928.966 users now.


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Contact Info / Websites
- None
All 8 movie Reviews
Rated 5 / 5 stars
I forgive you for your horrible, horrible mistake.
The Letter
Rated 5 / 5 stars
"Loved it!"
Very touching. described my 5th grade year (minus the happy ending)
I'm a sad, sad man (-_-''')
Thanks !
Aw, haha, hopefully you're having better luck now ;p
Punishing ACTA
Rated 5 / 5 stars
"Target acquired"
I agree. The threat must be eliminated...
Hank's Rage: Megaupload
Rated 5 / 5 stars
LOVED it. although, I say it needed Way more mindless, fast-paced, bloody action and waaaay more killing. also try to make your videos longer. I love your style, too. very... "perspective-y"?
Awesome Reach
Rated 5 / 5 stars
I watch this at LEAST once a month. :D
The Obnoxious Orange
Rated 3.5 / 5 stars
That was FUCKED.
CT Scrapped test
Rated 5 / 5 stars
Just wonderful
Clogged Tubes Ep 1
Rated 5 / 5 stars
I think im in love...


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PrimeSense and OpenNI
LinceoVR is comaptible with PrimeSense Sensor based devices using the OpenNI SDK. Download the Redistributable Package for Kinect Support follow the OpenNI Installation procedureto enable your compliant device and enjoy the body and gesture tracking features of LinceVR.
LinceoVR has been successfully tested with Miscrosoft Kinect Xbox360 and Asus Xtion.


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Will this still work for the Gen 2/3 Apple TV's? It looks like the height is flexible, but I'm not sure.
- Asked by Kevin Z from Hamilton
Innovelis TotalMount Pro Mounting System for Apple TV
Product No Longer Available
2 Answers from the Community
I forgot I asked this question. I ended up buying this for my Gen 4, but instead, used it for my Gen 3. IR works fairly well by reflecting off surfaces, so I put this on the back of my tv near the top and now I just point my Apple remote at the ceiling above the TV.
- Answered by Kevin Z from Grimsby
previous versions of Apple Tv's utilised remote controls that operated "line of sight", so basically if the remote couldn't see the black box, it didn't work. If you stick you 2/3 gen Apple TV box to the back of your TV, your gen 2/3 remote won't work.
There are of course ways around this problem with i.r. transmitters, but it becomes complicated and potentially adding to the clutter and untidy cables. : )
- Answered by Glen S from Perth


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The 2009 holiday gift-giving season has finally arrived. But this year many families are scaling back expenditures; others are trying to stay "green" with fewer plastic and battery-laden toys cluttering up the house. So for the little girls on your list, what are the meaningful and high-quality gifts that can be enjoyed throughout the year?
Girls ages 2 to 4: Girls at this age will appreciate a creative outlet. Consider giving a large wooden easel with a smock and paint supplies, or a magic wall panel with a dry-erase board and magnets. To make playtime seem more magical, consider a canopy playhouse or even a simple tent. For the doll lovers on your list, check out eco-friendly designs such as Earth Friends. If you shared a special event or vacation with her this year, collect the pictures and make her a printed photo book (available from Snapfish, Shutterfly, or any other major online photo gift resource).
For this age group, there are plenty of experiences that you can share as well. Give her art, music, gymnastics, or dance lessons, or promise her a day at the zoo or a kids' play center. For a special treat, wrap her a special ballet present: a pink tutu and a pair of tickets to a local dance performance.
Girls ages 5 to 7: Girls at this age will love the opportunity to expand their world. Give her a butterfly garden so she can hatch and release her own butterflies. Or for an organized little girl, consider a personalized wall calendar that she can adjust each day to keep track of seasons, weather, and special events. For the social type, give her a sleeping bag (which you can personalize with her initials or her name) to prepare for future slumber parties. Also check out Eco Dolls that look like "real" girls, with companion books about environmental learning adventures.
For an experiential gift, promise her a day at a museum or a trip to a concert. Also consider special theme ideas such as a tea party package (a new dress and a promise for a formal tea party at a local hotel or restaurant) or a day at the movies (a date for a matinee with popcorn).
Girls ages 8 to 12: "Tween" girls' love the opportunity to share with friends and keep special secrets. Creative types may enjoy a jewelry kit to make friendship bracelets. If she's a jewelry collector, give her a fancy new jewelry box or case. To help her record her special time with her friends, give her a small digital camera. And let her keep her secrets safe by giving her a journal or locking diary.
Above all, don't forget the gifts of time that you can give your favorite tween. Depending on what she loves to do, give her a day of beauty (a trip to the salon for a manicure and pedicure), a day of excitement (with tickets to watch her favorite sports team), or a day at the theater (with a special lunch before the show). Even better, consider a class that you and she might take together – jewelry making, scrapbooking, ceramics, cake decorating – anything that she might enjoy doing and would have fun learning with you.
Remember that you don't have to spend a lot of money or waste a lot of packaging to make a gift memorable. The best gifts are the ones that will help your little girl discover something new about herself, which is something she will treasure forever.


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Download your copy of Command today!
iBOOKS | AMAZON US | AMAZON UK | AMAZON CA | AMAZON AU | B&N | KOBO
My Rating:
Favorite Quotes:
"You're mine Harlow. Your heart, your body, you… all mine. And that drives me crazy some days."
I never judge another woman's choice in a man because I'm not the one walking in their shoes."
"I experienced a mixture of horror and satisfaction, and it felt wrong to be kind of satisfied at his pain, but after being threatened by two men in the last two days, I was all for them hurting."
"I'll marry you and be your wife, but a piece of paper doesn't make any difference to the fact I'm already yours."
"FYI, I'm marrying the Coleminator. I'll be sure to send you an invitation so you can drool."
"I knew I should have called in sick. Listening to your sexcapades with those Storm men may just kill me today."
My Review:
I love a dual POV and Command gives us both sides. Scott Cole is a bossy, moody, and cranky President of a biker club, but he is a soft sweet pussy cat for his precious Harlow James. He cannot speak without swearing and generally talks in a growl, but he protects every hair on her head. They have great passion and sizzling chemistry, as well as geography, history, and any other subject you want. The sensual scenes are sizzling but the suspense and intrigue are center stage in this volume.
Check out the rest of the series – I've read them all!


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Recently Added:
British Authentic Miniatures - Metal Greek Warrior
More Info
This collectible replica of a Greek warrior is in excellent condition (stamped "Authentic Miniatures" on its base) and was designed by T. Park (Glasow) . It measures 3.5 inches high and is hand painted. Wearing a feathered helmet and carrying a protective shield with a bull's head painted on it, the figure is authentically dressed except for a missing weapon (spear, axe). It is about 3.5 inches high. This would be a great first piece for a young person's collection.
If you are interested, please email me Thanks, Nancy


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SEC to Examine Outdated Rules Governing Funds' Operating Fees
WASHINGTON -- Is the 12b-1 fee to be or not to be?
In his first major speech to the mutual-funds industry, Securities and Exchange Commission Chairman Harvey Pitt warned that the regulatory agency is examining whether rules governing certain operating fees -- which most investors may not even realize their funds are paying -- have become outdated and may need to be overhauled.
The charges, called 12b-1 fees after the section in...


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Fire in downtown Macon leaves one dead
Wed, 26 Jun 2013 18:54:09 GMT —
The Macon Police Department now reports that Lawrence L. Flax, Jr., 41, of Macon, was found deceased after fire personnel battled a structure fire in downtown area Wednesday morning.
An autopsy is scheduled for Thursday at Boone County Medical Examiner's Office for the victim.
Authorities tell our sister station KTVO in Kirksville, Mo. the Macon Police and Fire Departments were called to the 100 block of North Rollins in downtown Macon just before 7 a.m. where there was a fire in an upstairs apartment. When firemen entered the apartment, they found Flax.
The Missouri State Fire Marshall's Office assisted in the investigation and according to Chief Steve Olinger, they are still looking into the cause of the fire.


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text: In this July 23, 2013, photo, people walk down the sidewalk in downtown Springfield, Vt. where Timothy J. Szad, a high-risk sex offender, is due to be released on Friday. State officials say it's necessary to notify a community when a high-risk sex offender is being released, but that notification can engender such an outcry that the plan for where the offender was going to live can fall apart.(AP Photo/Toby Talbot)


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All modern businesses must be technology oriented. Adopting latest technologies helps business to grow enjoying greater share of profitability. Moreover, technology reduces human efforts. As a result to that, cost of hiring human labors gets reduced significantly and at the same time higher level of accuracy can be established in the business process management. Manual techniques often lead to errors; while software based techniques or technology oriented services will always stay accurate. For business financial management and finance record keeping, use of Quicken can be noted quite expensively these days. From conventional businesses to nonconventional ecommerce businesses, everyone finds QuickBooks to be a helpful application for finance transaction tracking as well as management.
We offer expertise EDI solutions to the clients through effective as well as accurate QuickBooks integration. We offer end to end QuickBooks integration services, and among our various services QuickBooks EDI integration is definitely worth to be highlighted. EDI integration will help your business to track finances or transactions, manage warehouse and updating the purchased orders. In order words, it brings automation or more effectiveness within your business process management. It enhances accuracy so that reputation damaging errors can be avoided. With our QuickBooks EDI integration service, your business data shall be available to you in structured manner. Data, available in structured or organized form, will be easy to read or interpreted. As a result, business managers or owner will be able to make better business decisions.
In order to get the competitive edge over other rival businesses, a business needs to give importance to EDI. Proper EDI management and data interpretation will help your business to cut down unnecessary expenses. As a result, your business becomes poised to make more profitability. However to enjoy the benefits, you need to find a reliable service provider for QuickBooks EDI integration services. We hold professional knowledge and experience in this regard. Poised with excellent human resources or strained staffs and extensive knowledge, we offer the best as well as the most robust EDI and QuickBooks integration services.
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Most of the ecommerce businesses face a lot of logistic issues, especially those ecommerce businesses that want to activate multiple ecommerce channels. Facing logistic issues makes ecommerce businesses to suffer from various aspects. In most of the cases, it makes the ecommerce system or process unnecessary complication. As a result, possible errors take place and more expenses are experienced. To enhance accuracy of the system and to increase profitability, drop ad ship management process is important with QuickBooks integration. Integrating QuickBooks helps to make this process seamless, simple and advanced. We help our customers with seamless solution for EDI drop ship accounting integration with QuickBooks.
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Members Online:
Order of Nine Angles - The Septenary, Crowley, and The Origins of The Order of Nine Angles (20.0 Kb)
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Aleister Crowley is regarded, by the ONA, as a rather conventional, if somewhat eccentric, example of what it has been convenient to call The Right Hand Path that is, the ONA regards him as unconnected with any genuine Left Hand Path or any genuine Sinister Way. This is evident in many things, including (1) his reliance upon Old Aeon "Orders" and organizations, with their grand titles, their sycophancy, their "secret teachings revealed only to qualified initiates", and especially their presumption of awarding titles and ...
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Aleister Crowley is regarded, by the ONA, as a rather conventional, if somewhat eccentric, example of what it has been convenient to call The Right Hand Path that is, the ONA regards him as unconnected with any genuine Left Hand Path or any genuine Sinister Way. This is evident in many things, including (1) his reliance upon Old Aeon "Orders" and organizations, with their grand titles, their sycophancy, their "secret teachings revealed only to qualified initiates", and especially their presumption of awarding titles and magickal grades to others (2) that he never did any dark and sinister deeds - works of genuine evil - and neither did he and does he inspire any such works and deeds, or even the presencing of Chaos or genuine heresy and (3) the pseudo-mystical ramblings of his (and his followers) which pass for "esoteric teachings".
About Author:
The Order of Nine Angles (
) is a Satanic and Left-Hand Path occult group based in the United Kingdom, but with affiliated groups in various other parts of the world. Claiming to have been established in the 1960s, it arose to public recognition in the early 1980s.
Describing its approach as "
Traditional Satanism
", it has been academically identified as also exhibiting Hermetic and Neo-Pagan elements in its beliefs.
According to the Order's own account, it was established in the Welsh Marches of Western England during the late 1960s by a woman who had previously been involved in a secretive pre-Christian tradition surviving in the region. This account also states that in 1973 a man named "
Anton Long
" was initiated into the group, subsequently becoming its Grand Master. Several academic commentators to have studied the ONA express the view that the name "
Anton Long
" is probably the pseudonym of the British Neo-Nazi activist David Myatt, although Myatt has denied that this is the case. From the late 1970s onward, Long authored a number of books and articles propagating the Order's ideas, and in 1988 it began production of its own journal, Fenrir. Through these ventures it established links with other Neo-Nazi Satanist groups around the world, furthering its cause through embracing the internet in the 2000s.
The ONA promotes the idea that human history can be divided into a series of Aeons, each of which contain a corresponding human civilization. It expresses the view that the current Aeonic civilization is that of the Western, but claims that the evolution of this society is threatened by the "
" influence of Judeo-Christian religion, which the Order seeks to combat in order to establish a militaristic new social order, termed the "
". According to Order teachings, this is necessary in order for a Galactic civilization to form, in which "
" society will colonise the Milky Way. It advocates a spiritual path in which the practitioner is required to break societal taboos by isolating themselves from society, committing crimes, embracing political extremism and violence, and carrying out an act of human sacrifice. ONA members practice magick, believing that they are able to do so through channeling energies into our own "
" realm from an "
" realm where the laws of physics do not apply, with such magical actions designed to aid in the ultimate establishment of the Imperium.
The ONA lacks any central authority or structure, instead operating as a broad network of associates - termed the "
" - who are inspired by the texts originally authored by Long and other members of the "
Inner ONA
". The group comprises largely of clandestine cells, termed "
", as well as gangs known as Dreccs, artists known as Balobians, and folk mystics known as Rounwytha. With the first nexion based in Shropshire, Western England, the majority of groups have been established in the British Isles and Germany, although others have been formed elsewhere in Europe, Russia, South Africa, Australia, and North America. Academic estimates suggest that the number of individuals broadly associated with the Order falls in the low thousands.
Order of Nine Angles - Grimoire of Baphomet
Order of Nine Angles - Black Book of Satan
Order of Nine Angles - Collection of Various Manuscripts
Order of Nine Angles - Acausality, The Dark Gods, and The Order of Nine Angles
Order of Nine Angles - Baphomet (An Esoteric Signification)
Graham Yewbrey - John Dee And The Sidney Group Cosmopolitics And Protestant Activism In The 1570s
Jester Raiin - Major Arcana 2nd Update And 1st Typohunt
Franz Cumont - The Mysteries Of Mithra
Janet Farrar - A Witches Bible The Complete Witches Handbook
Review Only
Saint Yves D'Alveydre - Mission de L'Indie en Europe, Mission de l'Europe en Asie (1886,in French)
Benjamin Rowe - Enochian Temples A Ritual Of The Consecration Of The Temple Of The Fire Tablet
Aleister Crowley - Liber 051 Atlantis The Lost Continent
William Mansfield Groton - The Christian Eucharist and The Pagan Cults
Order of Nine Angles - Baphomet and Opfer
Howard Phillips Lovecraft - The Rats in the Walls
Gerald Gardner - The Garnerian Book of Shadows
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text:
Welcoming Remarks - Speaker Bios
Catherine A. Novelli, Under Secretary for Economic Growth, Energy, and the Environment, U.S. Department of State
Catherine A. Novelli was sworn in as Under Secretary of State for Economic Growth, Energy, and the Environment on February 18, 2014. In this capacity, she leads the State Department's efforts to develop and implement economic growth, energy, agricultural, oceans, environmental, and science and technology policies to promote economic prosperity and address global challenges in a transparent, rules-based, and sustainable system.
Prior to assuming her current duties, she was Vice President, Worldwide Government Affairs at Apple, Inc. In that role, Ms. Novelli headed a multinational international team responsible for Apple's federal, international, and state and local government relations and public policy.
Prior to her tenure at Apple, Ms. Novelli was a partner in the Washington office of Mayer, Brown, Rowe & Maw LLP where she assisted Fortune 100 clients on issues involving international trade and investment.
Formerly Assistant U.S. Trade Representative for Europe & the Mediterranean, Ms. Novelli coordinated U.S. trade and investment policy for the over 65 countries of Western Europe, Central Europe, Russia, the NIS, the Middle East and Northern Africa. She has taken a leading role in many of the most important U.S. trade negotiations in Europe, Russia, the Middle East, and North Africa. As the point person for the $1 trillion economic relationship between the United States and Europe, Ms. Novelli led efforts to ensure access to the European market for U.S. manufactured and agricultural products.
Ms. Novelli was the lead strategist in creating the United States' free trade agenda with the Middle East. She led free trade agreement negotiations with Jordan, Morocco and Bahrain, Oman and United Arab Emirates. She chaired the Trade and Investment Framework Councils with a number of countries in the region, including Turkey, Egypt, Tunisia, United Arab Emirates, Qatar, Kuwait, Saudi Arabia, and Algeria, and worked on other broad-based, public-private initiatives in the region.
Ms. Novelli has also played a critical role for the United States in Central Europe, Russia, Ukraine and Central Asia. As the Deputy Assistant U.S. Trade Representative for Central and Eastern Europe and Eurasia, she negotiated most of the bilateral trade and investment agreements that underpin our economic relationship in that region.
Prior to joining USTR, Ms. Novelli served in the Office of General Counsel at the Department of Commerce. Ms. Novelli is a graduate of Tufts University, holds a law degree from the University of Michigan and a Master of Laws from University of London (with concentrations in international and comparative law at the London School of Economics and School of Oriental and Asian Studies).
Matthew W. Barzun, Ambassador of the United States of America to the United Kingdom of Great Britain and Northern Ireland, U.S. Department of State
Matthew W. Barzun was selected by President Barack Obama as National Finance Chair for the president's 2012 re-election campaign. He previously served as U.S. Ambassador to Sweden from 2009 to 2011. Ambassador Barzun is an internet pioneer who was the fourth employee at CNET Networks, where he worked from 1993-2004. Ambassador Barzun served in a number of roles at CNET, including Executive Vice President, Chief Strategy officer, and member of the executive committee.
During his time there, he launched Download.Com, which grew to become CNET's biggest site and he led the effort to build one of the first comparison shopping sites on the Internet, Shopper.Com. He went on to co-lead all of CNET's online properties including CNET.Com and News.Com.
After leaving CNET in 2004, Ambassador Barzun has advised and invested in start-up internet companies, including MedTrackAlert, which delivered consumers information about their prescription medications (it was sold to HealthCentral in June 2008), and JiWire, an advertising network for wireless devices.
Ambassador Barzun was among the first to join Barack Obama's National Finance Committee before the President's election in 2008. In that capacity, he produced the first $25 per-person fundraiser and helped teach Obama University for campaign volunteers.
In Kentucky, Ambassador Barzun has served on the boards of many non-profits with a focus on education (the Louisville Free Public Library Foundation, Louisville Public Media, and Teach Kentucky); public policy (the Kentucky Long Term Policy Research Center, and The Greater Louisville Project) and interfaith relations (Center for Interfaith Relations).
He graduated Magna Cum Laude with an AB in History and Literature from Harvard College.
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-Photos Courtesy of The City of Tyler
The commonly used phrase "stop and smell the roses" has never been more appropriate to use than when passing through Tyler. Go out and explore the magnificent nature while admiring the fascinating culture of this East Texas town.
Fun Facts:
1. One-third of all commercially-grown rose bushes in America are produced in a 50-mile radius around Tyler.
2. The Tyler Skateplex has one of the largest skating floors in the nation.
Where to Stay: Memory Lane Inn
Memory Lane Inn is an early 1900s grand estate in the historic and posh downtown Brick Street District. The Inn is embellished with romantic textiles, charming paintings, classic antiquities, and imported stained glass doors. Choose from four elegant suites,all featuring private baths. Find peace hearing the serenity of flowing waterfalls and the splashing of koi fish while sipping your morning coffee on one of the shaded patios.
Where to Eat: Bernard's Mediterranean Restaurant
The family-owned and operated upscale dining establishment, Bernard's Mediterranean Restaurant, promotes an extraordinary take on classic cultural dishes. Guests can expect an
array of flavors from France, Spain, and Italy presented in afresh, modern fashion. At Bernard's, exceptional fine-dining in a friendly and relaxed atmosphere is guaranteed. Be sure to stop by the wine bar to discover the perfect pairings for your meal.
Where to Drink: Lago del Pino
Lago del Pino is a breathtaking venue which was inspired by a life of traveling the world. The venue is nestled alongside a picturesque 40-acre private lake in the west side ofTyler and boasts extraordinary dining, world-class cocktails, and live local music. Grab a table inside while enjoying the views from the second floor or venture out to the lakeside patio where numerous lounge areas and tables are waiting for you. There is no place more perfect to enjoy a day or night of relaxed drinking and good conversation.
Where to Relax:Tyler Rose Garden
If you love the sweet smell of roses and want to learn about the rich history of the Tyler Rose Parade, visit the 14 acre Tyler Rose Garden. Enjoy a leisure stroll through the rose center exhibits then head outside to walk the vast aisles of over 35,000 gorgeous rose bushes of endless colors. It's simply the most beautifully relaxing activity to do while inTyler. The Rose Garden is free to the public and is open from dusk 'til dawn.
Where to Explore: Caldwell Zoo
The Caldwell Zoo began from humble beginnings as a menagerie of squirrel sand parrots and has since evolved into an 85-acre regionally-acclaimed zoo containing more than2,000 animals representing 250 species from East Africa, North America, and South America.Explore beautiful habitats and learn about many of the world's most fascinating animals. TheCaldwell Zoo is open daily and has seasonal presentations and interactions such as bird shows and giraffe feedings.
Where to Shop: Ye Olde City Antique Mall
Who knew mere minutes away from downtown Tyler, sits a gateway to a surplus of old world charm. Take some time to enjoy the nostalgia of days past with a captivating visit to the completely restored Ye Olde City Antique Mall. Your shopping experience will be shaped by the friendliness of the staff and warmth of the atmosphere. With different surprises lurking around every corner, I challenge you to not fall in love with this unique antique shop.


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Learn Objective-C on the Mac
Paperback(1st Corrected ed., Corr. 3rd printing)
- Get it by Tuesday, October 24 , Order by 12:00 PM Eastern and choose Expedited Delivery during checkout.
Take your coding skills to the next level with this extensive guide to ObjectiveC, the native programming language for developing sophisticated software applications for Mac OS X. ObjectiveC is a powerful, objectoriented extension of C, making this book the perfect followup to Dave Mark's bestselling Learn C on the Mac, Mac OS X Edition. Whether you're an experienced C programmer or you're coming from a different language such as C++ or Java, leading Mac experts Mark Dalrymple and Scott Knaster show you how to harness the powers of ObjectiveC in your applications!
- A complete course on the basics of ObjectiveC using Apple's free Xcode tools
- An introduction to objectoriented programming
- Comprehensive coverage of inheritance, composition, object initialization, categories, protocols, memory management, and organizing source files
- A brief tour of Cocoa's foundation framework and AppKit
- A helpful "learning curve" guide for nonC developers
What you'll learn
- Learn ObjectiveC programming, the gateway to programming your Mac or iPhone
- Write applications for the Mac OS X interface, the cleanest userinterface around
- Understand variables and how to design your own data structures
- Work with the file system
- Connect to data sources and the Internet
Who this book is for
For anyone wanting to learn to program native applications in Mac OS X, including developers new to the Mac, developers new to ObjectiveC, or students entirely new to programming.
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About the Author
Mark Dalrymple has been a Mac developer since 1985 and a Unix programmer since 1990. Over the years, he has worked on projects ranging from cross-platform development tool kits to high-performance web server software servicing hundreds of millions of hits per day, medical applications, and video products for Hollywood. He is the coauthor of Core Mac OS X and Unix Programming and Advanced Mac OS X Programming.
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Ok, I read this book with three other seasoned Java developers. We all have an excellent grasp of core object oriented and general language principles. I started reading this book and got to chapter 5 and gave up and went and bought another Objective C book. The examples all worked, but the chapters themselves were missing core concepts, misleading, in some cases downright wrong. After a while I gave up. Not recommended.
Must be updated to be useful


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20 years ago, Harry Potter and the Philosopher's Stone was released in the UK.
I have loved every book, every film, every character (even the evil and mean ones!!) It really is a franchise that has had an impact on children's and adult's lives.
The four houses represented something different for each of us and we all knew which we really wanted to be in. For Griffindor you were brave, loyal, courageous, adventurous, daring and chivalrous. For Ravenclaw you were wise, intelligent, creative, clever and knowledgeable. For Hufflepuff you were loyal and patient, dedicated to hard work. And finally for Slytherin, the cunning, resourceful, intelligent and determined.
So for my #day3 of #100daysofhappiness it goes to you J.K Rowling and a series that has transformed a generation!


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What Research About Options Can Teach You


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By William Appleman Williams
"A amazing e-book on overseas affairs."―Adolf A. Berle Jr., New York instances e-book Review
This incisive interpretation of yankee international coverage ranks as a vintage in American suggestion. First released in 1959, the booklet provided an research of the wellsprings of yankee overseas coverage that make clear the tensions of the chilly battle and the deeper impulses resulting in the yank intervention in Vietnam. William Appleman Williams brilliantly explores the ways that ideology and political economic climate intertwined over the years to propel American enlargement and empire within the 19th and 20th centuries. The strong relevance of Williams's interpretation to global politics has merely been bolstered through contemporary occasions in important Asia and the Persian Gulf. Williams permits us to determine that the pursuits and ideology that after despatched American troops into Texas and California, or Latin the United States and East Asia, additionally propelled American forces into Iraq.
Read Online or Download The Tragedy of American Diplomacy (50th Anniversary Edition) PDF
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Extra info for The Tragedy of American Diplomacy (50th Anniversary Edition)
The us was once an "expanding" country. "Our industries have increased to this sort of element that they are going to burst their jackets in the event that they can't discover a unfastened outlet to the markets of the area. . . . Our family markets now not suffice. we want overseas markets. " and likewise, he further, a massive attempt to coach most of the people at the challenge and its answer. Wilson was once much more particular concerning the explanation for his feel of urgency at a crusade dinner for his supporters one of the operating classification. (Not many day employees may well have the funds for the costs, yet their leaders attended. ) "We have reached, in brief, a serious aspect within the means of our prosperity. It has now develop into a question with us," he warned, "whether it shall proceed or shall now not proceed. " "We desire overseas markets," he reiterated, simply because "our family industry is simply too small. " And as McKinley and Root sooner than him, Wilson in 1912 unequivocally pointed to Germany because the most deadly rival of the U.S. in that fiscal fight. Wilson's dramatic language approximately American prosperity appeared inside a yr to were justified. The kingdom entered a recession on the finish of 1913, and the downswing persisted in 1914. Even sooner than that unsatisfied improvement, or earlier than he needed to focus on the Mexican and Russian Revolutions, Wilson printed the willing and complex manner within which he built-in crusading idealism and hard-headed economics. the location during which he displayed such management was once nearly actually expecting him as he moved into the White apartment in March 1913. immense American bankers sought after a steered if now not fast coverage assertion on their efforts (in conjunction with the japanese and ecu financiers) to push via a wide mortgage to China. Wilson's reaction has often been interpreted as an abrupt and demanding holiday with the complete culture and perform of out of the country monetary growth. That end has been reached by way of an highbrow wide bounce of prodigious proportions, setting out from the truth that Wilson did refuse to help the bankers in that one operation. yet historic interpretation isn't really wide leaping. in actual fact undeniable. the belief is incorrect. as a way to comprehend the plain contradiction in Wilson's motion, although, it is vital to contemplate a number of components which are seldom built-in into the research. ¶ it truly is crucial to begin with to study the problems that arose in placing the open door procedure into operation in Asia. Given the target of successful the commercial and political victory with out the battle (or wars), American leaders confronted a tough job. there has been no effortless solution to their difficulties, and most likely no instruction manual of operations for them to keep on with. that they had to make tricky offerings in innovating strategies, and to deal with boundaries and different problems imposed by way of occasions at domestic and in China. to prevent confusion in outlining such issues (all of them can't be summarized in a single neat paragraph), they are going to be numbered. First: the normal and noticeable tactic used to be to head it on my own, plunging forward in China with the wish of quickly developing broad American impact.


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Thursday, 22 June 2017
Drug And Alcohol Treatment Centers For Pregnant Women In south Dakota
Addiction treatment programs and detox facilities are normally set up to treat a particular type of patient. In the state of South Dakota are just over five different facilities available to treat pregnant women struggling with addiction. These programs are set up specifically to offer addiction treatment and detox, specifically for a woman whom is pregnant. Getting the help as quickly as possible is very important, and must be done safely to protect the mother and fetus.
Here is a list of alcohol and drug programs for Pregnant Women in South Dakota. The list can be incomplete so please do not hesitate to contact one of our counselors at 1-800-304-2219.
The listing below is sorted by cities in alphabetic order.


text: ShareMonitor is a Windows-based tool that shows you who is looking at your shared folders and files. Viewing who is doing what on your shared files is displayed in an easy to read table. You can view the details in real-time or export the table in a CSV or XML file. ShareMonitor is currently freeware and is Windows only. [ShareMonitor via Addictive Tips]


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SR has received speaker fees from Pfizer. MC has no conflict of interest. AA has received speaker or consultant fees from Pfizer, Sanofi-Aventis, GlaxoSmithKline (GSK), Jansen-Cilag, UCB Pharma, EISAI, and Valeant. PR has received speaker fees from Cyberonics, Eisai, GSK, Janssen-Cilag, Novartis, Pfizer, Sanofi-Synthelabo, and UCB; and consultant fees from Cyberonics, GSK, Janssen-Cilag, Novartis, Pfizer, UCB, and Valeant.
Despite guidelines establishing the need to perform comprehensive paediatric drug development programs, pivotal trials in children with epilepsy have been completed mostly in Phase IV as a postapproval replication of adult data. However, it has been shown that the treatment response in children can differ from that in adults. It has not been investigated whether differences in drug effect between adults and children might occur in the treatment of drug-resistant partial epilepsy, although such differences may have a substantial impact on the design and results of paediatric randomised controlled trials (RCTs).
Three electronic databases were searched for RCTs investigating any antiepileptic drug (AED) in the add-on treatment of drug-resistant partial epilepsy in both children and adults. The treatment effect was compared between the two age groups using the ratio of the relative risk (RR) of the 50% responder rate between active AEDs treatment and placebo groups, as well as meta-regression. Differences in the response to placebo and to active treatment were searched using logistic regression. A comparable approach was used for analysing secondary endpoints, including seizure-free rate, total and adverse events-related withdrawal rates, and withdrawal rate for seizure aggravation. Five AEDs were evaluated in both adults and children with drug-resistant partial epilepsy in 32 RCTs. The treatment effect was significantly lower in children than in adults (RR ratio: 0.67 [95% confidence interval (CI) 0.51–0.89];
Children with drug-resistant partial epilepsy receiving placebo in double-blind RCTs demonstrated significantly greater 50% responder rate than adults, probably reflecting increased placebo and regression to the mean effects. Paediatric clinical trial designs should account for these age-dependent variations of the response to placebo to reduce the risk of an underestimated sample size that could result in falsely negative trials.
In a systematic review of antiepileptic drugs, Philippe Ryvlin and colleagues find that children with drug-resistant partial epilepsy enrolled in trials seem to have a greater response to placebo than adults enrolled in such trials.
Whenever an adult is given a drug to treat a specific condition, that drug will have been tested in "randomized controlled trials" (RCTs). In RCTs, a drug's effects are compared to those of another drug for the same condition (or to a placebo, dummy drug) by giving groups of adult patients the different treatments and measuring how well each drug deals with the condition and whether it has any other effects on the patients' health. However, many drugs given to children have only been tested in adults, the assumption being that children can safely take the same drugs as adults provided the dose is scaled down. This approach to treatment is generally taken in epilepsy, a common brain disorder in children in which disruptions in the electrical activity of part (partial epilepsy) or all (generalized epilepsy) of the brain cause seizures. The symptoms of epilepsy depend on which part of the brain is disrupted and can include abnormal sensations, loss of consciousness, or convulsions. Most but not all patients can be successfully treated with antiepileptic drugs, which reduce or stop the occurrence of seizures.
It is increasingly clear that children and adults respond differently to many drugs, including antiepileptic drugs. For example, children often break down drugs differently from adults, so a safe dose for an adult may be fatal to a child even after scaling down for body size, or it may be ineffective because of quicker clearance from the child's body. Consequently, regulatory bodies around the world now require comprehensive drug development programs in children as well as in adults. However, for pediatric trials to yield useful results, the general differences in the treatment response between children and adults must first be determined and then allowed for in the design of pediatric RCTs. In this study, the researchers investigate whether there is any evidence in published RCTs for age-dependent differences in the response to antiepileptic drugs in drug-resistant partial epilepsy.
The researchers searched the literature for reports of RCTs on the effects of antiepileptic drugs in the add-on treatment of drug-resistant partial epilepsy in children and in adults—that is, trials that compared the effects of giving an additional antiepileptic drug with those of giving a placebo by asking what fraction of patients given each treatment had a 50% reduction in seizure frequency during the treatment period compared to a baseline period (the "50% responder rate"). This "systematic review" yielded 32 RCTs, including five pediatric RCTs. The researchers then compared the treatment effect (the ratio of the 50% responder rate in the treatment arm to the placebo arm) in the two age groups using a statistical approach called "meta-analysis" to pool the results of these studies. The treatment effect, they report, was significantly lower in children than in adults. Further analysis indicated that this difference was because more children than adults responded to the placebo. Nearly 1 in 5 children had a 50% reduction in seizure rate when given a placebo compared to only 1 in 10 adults. About a third of both children and adults had a 50% reduction in seizure rate when given antiepileptic drugs.
These findings, although limited by the small number of pediatric trials done so far, suggest that children with drug-resistant partial epilepsy respond more strongly in RCTs to placebo than adults. Although additional studies need to be done to find an explanation for this observation and to discover whether anything similar occurs in other conditions, this difference between children and adults should be taken into account in the design of future pediatric trials on the effects of antiepileptic drugs, and possibly drugs for other conditions. Specifically, to reduce the risk of false-negative results, this finding suggests that it might be necessary to increase the size of future pediatric trials to ensure that the trials have enough power to discover effects of the drugs tested, if they exist.
Please access these Web sites via the online version of this summary at
This study is further discussed in a
The European Medicines Agency provides information about
The US Food and Drug Administration
The MedlinePlus encyclopedia has a page on
Epilepsy is a common disorder in children that often requires antiepileptic drug (AED) treatment for many years [
It has been shown that unpredictable differences may exist in drug metabolism and treatment response between children and adults [
Whether age differences might exist in the treatment of drug-resistant partial epilepsy has never been investigated, despite the possibility that they may have an important impact on the design of paediatric trials. Specifically, a greater placebo effect in children than in adults would narrow the expected effect size of AED treatment in the former population, and it could lead to falsely negative RCT outcomes if the sample size is directly extrapolated from data collected in adult studies. To test this issue we performed a meta-analysis that compared AED efficacy in paediatric and adult RCTs.
Three electronic databases (MEDLINE, EMBASE, and the Cochrane Library) were searched from 1960 to 30 June 2007, for RCTs investigating any AED in the add-on treatment of drug-resistant partial epilepsy. A detailed search strategy is provided in
The following criteria were used to select relevant RCTs: double-blind placebo-controlled design; patients with drug-resistant partial epilepsy with or without secondary generalization; adequate method of concealment of randomization (e.g., allocation of sequentially numbered sealed packages of medication, sealed opaque envelopes, telephone randomization) minimum baseline period 4 wk; minimum treatment phase 8 wk; efficacy as a primary endpoint; available data regarding the 50% responder rate; and number of withdrawals due to loss to follow up unlikely to affect the robustness of the results. Only drugs that have been evaluated in both adult and paediatric populations were included in further analyses.
We focused on drug-resistant partial epilepsy for several reasons. AEDs are first evaluated in patients with this condition before being tested in those with newly diagnosed epilepsy and refractory generalised epilepsies [
Drug-resistant partial epilepsy is defined by the International League Against Epilepsy (ILAE;
The following information were extracted and entered independently into databases by two investigators (SR and PR): (i)
For crossover studies, the first treatment period was treated as a parallel trial (i.e., only data from the first treatment period were used), and we discarded the second treatment period. If data provided by the authors in tables differed slightly from published figures, the tabular data were used. If some information about study design or seizure outcomes were not reported, the authors were contacted to obtain the required information.
Trials were finally classified as paediatric or adult trials according to the age of the patients. Paediatric trials were defined by a maximum age of patients < 18 y [
The results of the two resulting databases were compared and disagreements resolved by consensus. The quality of the reports was assessed by the Jadad score [
The primary endpoint was the 50% responder rate (50% or greater reduction in seizure frequency during the treatment period as compared to baseline). All doses evaluated in trials were included. A secondary analysis was restricted to comparable doses between paediatric and adult studies. Dosages were considered "comparable" when the difference between paediatric and adult doses (expressed in mg/kg) was < 35%. In adult trials, where the target dose was never adjusted to body weight, we calculated the mean dose (mg/kg) by dividing the target dose (mg) by the average body weight of the population. When this latter information was not provided, we used the average body weight observed in the other trials included in our study (i.e., 70 kg).
Secondary endpoints included the seizure-free rate (no seizure during the entire treatment period); the total withdrawal rate, which included all dropouts occurring during the treatment period; the adverse events withdrawal rate, which included only dropouts related to side effects; and the withdrawal rate for seizure aggravation.
The 50% responder and withdrawal rates for active AEDs treatment and placebo arms were extracted in an ITT analysis on the whole treatment period.
The seizure-free rate for active AEDs treatment and placebo arms was extracted in a modified ITT analysis. Only patients who remained seizure free during the entire treatment period were considered to achieve seizure-free outcome. Indeed, the alternative use of standard ITT analysis, based on the principle of last observation carried forward, has been considered inappropriate for analysing seizure-free outcome [
To evaluate efficacy of AEDs, we performed a meta-analysis that compared the 50% responder rate in active AEDs treatment group with the one observed in placebo group, and used the logarithm of relative risk method. This analysis was done separately in paediatric and in adult populations. Treatment effect and heterogeneity tests were performed, and a
To compare efficacy of AEDs in children and in adults, we calculated for each drug the ratio of the RR of the 50% responder rate observed in paediatric and in adult trials. To further assess the robustness of this ratio, we used a meta-regression approach with the log odds ratio as a dependent variable and a restricted maximum likelihood method for the estimation. Subanalyses were planned a priori to determine whether doses of AEDs or methodological quality was responsible for significant heterogeneity. The same statistical methods were used to analyse the seizure-free rate, the total withdrawal rate, the adverse events withdrawal rate, and the withdrawal rate for seizure aggravation.
Meta-analyses were performed using the software EasyMA [
The baseline risk of the primary and secondary endpoints was compared between adult and paediatric trials using logistic regression, with a level of significance at
The initial search for RCTs investigating any AED in the add-on treatment of drug-resistant partial epilepsy yielded 2,122 articles. A review of the abstracts and exclusion of irrelevant and duplicate articles yielded 109 articles (
Five drugs—gabapentin (GBP), levetiracetam (LEV), lamotrigine (LTG), oxcarbazepine (OXC), and topiramate (TPM)—were evaluated in 32 RCTs fulfilling our inclusion criteria, with at least one trial in children and another one in adults for each AED. Five RCTs included children; the other 27 included adults. The main characteristics and results of these trials are given in
Characteristics of Studies Included in the Meta-Analysis
Percentages of 50% Responders, Seizure-Free Patients, and Withdrawals
I2, point estimates of Higgins I2 with confidence interval; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.
Indirect comparison of the RR of the 50% responder rate in adults and children showed lower values in children (1.91 [95% CI 1.54–2.37]) than in adults (2.90 [2.47–3.41]), with confidence intervals that did not overlap (
(A) RR of 50% responder rate in adult and paediatric trials and comparison of RR of 50% responder rate in children and adults.
(B) Mean 50% responder rate with placebo and with AED in adult and paediatric trials. *
I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.
The above findings were found to primarily reflect differences in the response of the two populations to placebo. Indeed, logistic regression showed that the mean 50% responder rate in patients receiving placebo was significantly higher in children (19% ± 2.3%) than in adults (9.9% ± 4.6%) (
All above results remained valid when the same analyses were restricted to comparable doses between paediatric and adult trials (
The seizure-free rate was provided in only 15 of the 32 trials, including 11 of the 27 adults trials and four of the five paediatric trials (
The RR of seizure-free rate was 4.19 (95% CI 1.45–12.14) in adult trials and 5.00 (1.52–16.42) in paediatric trials. There was no significant difference between adult and paediatric studies (RR ratio 1.42 [95% CI 0.23–8.77],
(A) RR of seizure-free rate in adult and paediatric trials and comparison of RR of seizure-free rate in children and adults.
(B) Mean seizure-free rate with placebo and with AED in adult and paediatric trials.
I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.
In adults, both the total and adverse events withdrawal rates were significantly more frequent in treatment than in placebo arms. Indeed, the RR of the withdrawal rates for any reason and for adverse events were respectively 1.57 (95% CI 1.33–1.86) and 2.49 (1.90–3.28) (
(A) RR of withdrawal for any reason in adult and paediatric trials and comparison of RR of the total withdrawal rate in children and adults.
(B) Comparison of RR of the adverse events withdrawal rate in children and adults.
(C) Comparison of RR of the withdrawal rate related to seizure aggravation in children and adults.
(D) Mean withdrawal rate for either any reasons, adverse events or seizure aggravation with placebo and with AED in adult and paediatric trials. *
I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.
The meta-analysis of the RR ratio for the adverse events withdrawal rate also demonstrated significantly lower values in children than in adult RCTs, with a ratio of 0.51 (95% CI 0.26–0.98,
There was no difference in the RR of withdrawal rate for seizure aggravation between adults (0.74 [95% CI 0.28–1.98],
There was no difference between paediatric and adult trials in loss to follow-up and consent withdrawal (
In this meta-analysis, we found that the RR of the 50% responder rate for active AEDs over placebo, one of the main measurements of AED efficacy in drug-resistant partial epilepsy, was significantly lower in paediatric trials than in adult ones. This difference was primarily related to a 2-fold higher placebo responder rate in children than in adults. Such a difference, if ignored, could well result in an underestimation of the placebo response and type II errors in paediatric RCTs.
Only five RCTs fulfilling our selection criteria were performed in children, representing one trial per AED. Thus, each paediatric trial might have had an important weight in the meta-analysis. However, the very consistent findings observed among four of the five selected AEDs strongly suggest that our main result did not depend on any single paediatric trial, but rather on the consistency of the majority of RCTs in children.
Our study focused on refractory partial epilepsy, for which AEDs are usually tested during Phases II and III before further evaluation is considered in newly diagnosed epilepsy and refractory generalised epileptic syndromes. Diagnosis of partial seizures was always based on the association of ictal signs and symptoms suggesting an underlying focal neuronal discharge and consistent neurophysiological findings on a recent electroencephalogram. According to these inclusion criteria, it is very unlikely that the patients included in the selected RCTs could have been misdiagnosed.
However, differences in the type of partial epilepsy might account for the opposite trend observed for LTG as compared to the four other AEDs, with higher RR of 50% responder rate in children than in adults. Idiopathic partial epilepsies, which are typically benign conditions, are excluded in Phase III RCTs performed in adult patients with drug-resistant partial epilepsy, and are also unlikely to meet the inclusion criteria of RCTs performed in children with refractory partial seizures. Accordingly, there was no indication that patients with idiopathic epilepsy were included in the RCTs selected for this meta-analysis, with the exception of the LTG paediatric trial in which 40% of patients were classified as having idiopathic epilepsy [
More generally, we cannot exclude the possibility that clinical heterogeneity between adults and children as well as between trials in the same age group might have interfered with our results. It has recently been suggested that the statistical tests available for evaluating heterogeneity between studies (i.e., Cochran Q and Higgins I2) may suffer some limitations [
The reluctance to recruit children with epilepsy into AEDs trials [
Drug dosages differed between adult and paediatric trials, partly reflecting the fact that the clearance of modern AEDs is 20%–170% higher in children than in adults [
We used an ITT assessment that may be overly conservative. However, it must be stressed that the same method was used in all the Cochrane systematic reviews of AEDs [
Finally, whether the age-dependent variation of the response to placebo observed in this study might apply to generalized epilepsies remains to be determined.
The overall difference in the RR of being a 50% responder between adult and paediatric trials was primarily related to an age-dependent variation in the response to placebo. Indeed, placebo 50% responder rate was 1.9 times higher in children than in adults, in a very consistent way across all AEDs, including LTG. It has been suggested that the response to placebo may depend on the age of patients [
The reasons underlying the higher response to placebo in paediatric populations remains largely unknown and mostly speculative. In placebo-controlled studies of antimigraine agents, adolescents were more likely to believe that the treatment received was an effective pain relieving medication than were adults [
In contrast to the difference in the RR of the 50% responder rate observed between children and adults, the RR of the seizure-free rate was found to be comparable in the two populations. Seizure-free rates in placebo groups were quite low in both children (0.6%) and adults (0.4%), suggesting that this outcome is insensitive to nonpharmacological effects. However, the seizure-free rate was also low in patients receiving AEDs (4.5% in children and 2.8% in adults), accounting for the fact that this outcome failed to show a significant difference between active treatment and placebo arms in the 11 series in which it was available. Thus, the seizure-free rate, though representing a more clinically relevant and less placebo-sensitive outcome than the 50% responder rate, appears inappropriate for Phase III RCTs in patients with drug-resistant partial epilepsy.
We observed a significantly lower RR of the withdrawal rate in children than in adults, primarily reflecting a greater dropout rate from placebo arms in the former population (13.3%) than in the latter (7%). This greater dropout rate in placebo-treated children might have theoretically contributed to the increased 50% responder rate observed in the same population. Indeed, according to the method of last observation carried forward used in all the selected RCTs, patients who withdraw early from the study because of adverse events might be more likely to achieve a 50% reduction in seizure frequency during the shorter time spent in the trial. However, this possibility does not seem to apply to our findings, since the greater withdrawal rate observed in children receiving placebo was primarily due to more frequent aggravation of seizures in these patients (5.6%) than in adults allocated to placebo (0.7%).
The impact of our findings on future AED development programs in children needs to be emphasized. Recent reviews and guidelines have established that comprehensive drug development is needed in paediatric populations, including double-blind RCTs, but also have stressed the difficulties in achieving this goal [
The value of add-on placebo-controlled RCTs in children with drug-resistant partial epilepsy may also be in question. Other trial designs such as the comparison of low and high doses of the same drug [
(A) RR of 50% responder rate in adult and paediatric trials and comparison of RR of 50% responder rate in children and adults.
(B) Mean 50% responder rate with placebo and with AED in adult and paediatric trials. *
I2, point estimates of Higgins I2 with confidence interval; k, total number of trials; n, total number of patients; p Het, value of the heterogeneity test; p TE, value of the treatment effect test.
antiepileptic drug
confidence interval
intention to treat
randomized controlled trial
relative risk


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Warm your heart on May 21 with a screening of 'ET'
at Flicks in the Sticks
Flicks in the Sticks will be finishing its current season with a fun-filled family screening of that timeless classic 'ET -- The Extra Terrestrial'.
Flicks Director Trent Harvison says "We'd like to thank all of our patrons for attending our screenings since we commenced in December 2009, but with the colder weather rapidly approaching, we'll take a break over the cooler months and return bigger and better in the Spring"
"ET is sure to appeal to everybody -- kids love it and for adults it's a nostalgic trip down memory lane to when they first saw it," says Trent "We always ask our patrons for what they'd like us to screen and ET is always at the top of the list."
"If you've never been to Flicks before, now's your last chance for a few months. What a great way to enjoy the last of the warm weather outdoors in a family friendly environment while watching an all-time classic"
The Eumundi Showgrounds gates will open to moviegoers from 5pm, with the screening starting around 6.15pmish. BYO rug, chair or blanket, with beanbags available for hire.
A full candy bar will be in operation with all the usual goodies, including gourmet hot dogs, curries, and Mediterranean mezze plates.
"The cost for the night is only $8 per person, and it's free for children under three years of age," says Trent. "The price also includes a glow light and a locally handmade chocolate or drink, and we think it just might be the best value night out on the Coast!"
Flicks in the Sticks is at the Eumundi Showgrounds, a secure family-friendly venue at the Cooroy end of Memorial Drive, Eumundi.
For more information on Flicks in the Sticks, please visit our website at www.flicksinthesticks.org or phone 0458 128 020.
A bit about the movie...
While visiting the Earth at Night, a group of alien botanists is discovered and disturbed by an approaching human task force. Due to the hasty take-off, one of the visitors is left behind. The little alien finds himself all alone on a very strange planet. Fortunately, the extra-terrestrial soon finds a friend and emotional companion in 10-year-old Elliot, who discovered him looking for food in his family's garden shed. While E.T. slowly gets acquainted with Elliot's brother Michael, his sister Gertie, as well as with Earth customs, members of the task force work day and night to track down the whereabouts of Earth's first visitor from Outer Space.
The wish to go home again is strong in E.T., and after being able to communicate with Elliot and the others, E.T. starts building an improvised device to send a message home for his folks to come and pick him up. But before long, E.T. gets seriously sick, and because of his special connection to Elliot, the young boy suffers, too. The situation gets critical when the task force finally intervenes. By then, all help may already be too late, and there's no alien spaceship in sight...
Eumundi Showgrounds, Eumundi
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Rainbow at Geiranger fjord, Norway
Great captue!
very nice capture indeed - I would correct the ccw tilt to get the horizon leveled though.
Well captured image! I visited Norway a couple of years ago and Geiranger Fjord was one of the highlights of my trip. Brings back great memories. Thanks!
This one just oozes atmosphere. Well done


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brawny meaning in General Dictionary
Having big strong muscle tissue muscular fleshy powerful
View more
- (of one) possessing real power and fat; rugged and effective
- Having large, strong muscle tissue; muscular; fleshy; powerful.
brawny meaning in Etymology Dictionary
1590s, "characterized by muscle tissue," from brawn + -y (2).
brawny meaning in General Dictionary
(a.) Having huge, powerful muscles; muscular; fleshy; strong.
Sentence Examples with the word brawny
Dropping his harpoon, the brawny savage caught him in his arms, and by an almost miraculous dexterity and strength, sent him high up bodily into the air; then slightly tapping his stern in mid-somerset, the fellow landed with bursting lungs upon his feet, while Queequeg, turning his back upon him, lighted his tomahawk pipe and passed it to me for a puff.


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Motocross Suspensions
- Fork Adjusters (6)
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Most Recent Suspension Reviews
See all reviews for this product Pro Honda SS-7 5W Suspension Fluid ThissitewontacceptJJ - Washington, USA Decent product. "Works as it should. My only issue is the 16oz bottle and the CRF250R fork that requires 19oz . Poor package planning on Honda's part (or really smart for 1 more sale)"
See all reviews for this product
Dirt Bike Suspension
Every year the top pros in Motocross spend time testing and tweaking the settings on their dirt bikes. Much of this deals in the art of suspension. It's a finicky thing and for finicky riders it can mean the difference between stepping on the podium and simply finishing.
Most riders manage through a bad set-up, at least for a while, but the fatigue eventually sets in and quickly tires the most seasoned veteran. That's why the suspension set-up is so crucial. So, if you need replacement parts for warn out seals or bushings, new springs or a linkage arm, MotoSport is the best place to dial in your dirt bike's suspension.
We carry everything related to the suspension set-up including bearing kits, fork adjuster, fork bleeders, fork oil, lowering kits and all the tools required to get the job done. Use a sag scale to get your suspension settings just right. Grab a holeshot device to improve your starts. A finely tuned suspension might provide that edge to finally get into the Top 10 or allow you to blaze the trails for an afternoon without feeling exhausted after an hour.
Give us a call at 888-676-8853 with any questions regarding dirt bike suspension or use the Live Chat. We'll get you the parts by race day and orders more than $79 ship free.


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Thursday, September 4, 2014
RECIPE VIDEO: Oat Milk
I'm back with another recipe video! I told you I had tons of stuff to share with you, didn't I?
Living here is just so inspiring, I can't help it!
Today's video is a super easy, fast and cheap way to make an alternative milk. There is so much information out there about how horrible cow's milk is for you. Especially when it's from conventional factory farmed cows. Isn't it time we finally found a replacement? You can buy almond milk and various other nut milks at the store… but they too are filled with chemicals. There is a certain amount of Empowerment in making things yourself. When you do, you control exactly that's in it- both to suit your taste AND to lower your toxic load.
I guarantee this is the easiest and cheapest alternative to cow's milk available. Once you start making it yourself, you will never go back. Promise!
Empowered Living is all about finding new information about the way you've been living your life and making changes to improve your health and spirit. You can NEVER un-know what you learn.
If you are curious about why milk is so bad even though the media is programming you differently, research online. www.notmilk.com is a great resource!
Share this video with your friends. Never underestimate your power to change the lives of others. :)
Have a great weekend!
PS- if you would like to view the video larger, after you click "play" you will see a YouTube icon in the bottom right corner. Click on that and you will be able to change the size. :)
14 comments:
Meg this was a great video. I would never have thought one could use oatmeal to make a variation on milk. Anyway, keep up the good work. Also, I liked the music at the end--very South American sounding.ReplyDeleteReplies
Thanks so much! :) I love that music too! It makes me want to dance.Delete
- AnonymousSeptember 4, 2014 at 11:14 AM
I am so excited to try this! With my son's allergies, we had to cut out coconut and almond milks, so I am happy to find a healthy alternative to cow's milk for him!ReplyDeleteReplies
Yay! I'm glad you found a good alternative! If he is going to drink this, make sure to put some natural sweetener, cinnamon, vanilla or something else in it so it will taste less bland. He will love it and he will love helping make his special milk with you. :) Please let me know how it goes.Delete
Wow so easy! I have to try it!!ReplyDeleteReplies
Let me know if you guys try it! It's so fun to make!! Miss you both!! We need to talk soon. :)Delete
Awesome video Meg. Where is the vegan mac and cheese recipe? Hope all is well with you and your husband in Ecuador.ReplyDelete
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- Toyglobe Total Disgrace Internet
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- Report: #528344
TOYGLOBEInternet United States of America
TOYGLOBE TOTAL THIEF! Internet
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I placed a substantial order with this company.
They took my money almost immediatley and I have had no communication, no items and a very, very uspet little girl.
From reading other reports (which I should have done before I placed this order) I would have been much the wiser. I only wanted to get my daughter what she really wanted.
This is the first overseas dealings I have had that has ended this way - with TOYGLOBE they have taken my money and I have received nothing else.
This report was posted on Ripoff Report on 11/25/2009 12:10 AM and is a permanent record located here: http://www.ripoffreport.com/reports/toyglobe/internet/toyglobe-total-thief-internet-528344. The posting time indicated is Arizona local time. Arizona does not observe daylight savings so the post time may be Mountain or Pacific depending on the time of year.
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When Abdullah, a Taliban commander in central Afghanistan, needs more rifles and ammunition, he turns to the same people who pay his $580-a-month salary: his Iranian sponsors.
"Iran supplies us with whatever we need," he said.
Afghan and Western officials say Tehran has quietly increased its supply of weapons, ammunition and funding to the Taliban, and is now recruiting and training their fighters, posing a new threat to Afghanistan's fragile security.
Iran's strategy in backing the Taliban is twofold, these officials say: countering U.S. influence in the region and providing a counterweight to Islamic State's move into the Taliban's territory in Afghanistan. …
"Iran is betting on the re-emergence of the Taliban," said a Western diplomat. "They are uncertain about where Afghanistan is heading right now, so they are hedging their bets."


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Pencil Pull® and Tug-N-Back Writer® are retractable holders for writing instruments. Use it and you will never lose or drop your pen or pencil, or marker. These patented products are used by millions of people. Benefits:
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Certificate of Henry Cassidy, 4 August 1811
Certificate of Henry Cassidy
I do Certify that I can make oath if required that in the year 1805 when I came to st Louis to enter the Titles Papers of Elisha Winters & Gabriel Winters Lands at the Arkansas that I advised with General Wilkinson on the subject and that he advised me to Employ Rufus Easton Esqr as agent for the claim Saying at the time that he was a man of honor & abilities and would do me Justice in attending to the Interest of the Claimants Given under my hand at St Louis the 4th Augt 1811
Henry Cassidy
The above named Gentleman has been and is appointed a judge of the Courts of Arkansas District by Governor Howard—
MS (MHi); certificate and signature in Cassidy's hand, with postscript and address in an unidentified hand; addressed: "The Honorable Thomas Jefferson Monticello Virginia"; franked; postmarked Saint Louis, 8 Aug.; endorsed by TJ as a letter from Cassidy received 5 Sept. 1811 and so recorded in SJL.
Henry Cassidy, attorney and real-estate investor, was appointed a justice of the peace in the Cape Girardeau district of the Louisiana Territory in 1806, a deputy surveyor in 1807, a judge of the Arkansas District courts in 1811, and a township justice in the newly created Missouri Territory in 1813. He was given a full four-year term as township justice in 1814, and he briefly represented Arkansas County in the Missouri legislature. In addition, Cassidy was named attorney of the second judicial circuit of the new Arkansas Territory in August 1819, lost a bid to become Arkansas's first delegate to Congress that November, and was clerk of the Arkansas House of Representatives in the autumn of 1820. Thirteen members of the territorial legislature unsuccessfully recommended him for a seat on the superior court the same year. According to Arkansas's executive register, Cassidy "decamped in the dark" from his position as public attorney during the spring of 1821 (Terr. Papers description begins Clarence E. Carter and John Porter Bloom, eds., The Territorial Papers of the United States, 1934–75, 28 vols. description ends , 13:546, 14:150–1, 650, 795, 19:118–9, 170–1, 789; Lynn Foster, "Courts and Lawyers on the Arkansas Frontier: The First Years of American Justice," Arkansas Historical Quarterly 62 [2003]: 307, 311–7; Arkansas Gazette, 1 Jan., 7 Oct. 1820).
On 6 Aug. 1811 Cassidy swore before Justice of the Peace Thomas F. Riddick to an affidavit of which the opening paragraph was substantially the same as the above certificate, with an added assertion that James wilkinson had indicated that Rufus Easton's work for Cassidy "would not be in any manner inconsistent with the station of the said Easton as a judge of the Territory." The concluding paragraph affirmed that Wilkinson had recommended his namesake son to transact Cassidy's legal business even though he was "attached to the army." Cassidy sent the affidavit to Postmaster General Gideon Granger late in December 1811 (Terr. Papers description begins Clarence E. Carter and John Porter Bloom, eds., The Territorial Papers of the United States, 1934–75, 28 vols. description ends , 14:463–4). He seems to have been accusing General Wilkinson of encouraging Easton and the younger Wilkinson to engage in conflicts of interest.
Index Entries
- Arkansas District (Louisiana Territory); judges in search
- Arkansas District (Louisiana Territory); land claims in search
- Cassidy, Henry; and Arkansas judgeship search
- Cassidy, Henry; certificate of search
- Cassidy, Henry; identified search
- Easton, Rufus; and land claims search
- Granger, Gideon; as postmaster general search
- Howard, Benjamin; governor of La. Territory search
- Riddick, Thomas F.; as justice of the peace search
- Wilkinson, James; H. Cassidy's accusation of corruption search
- Wilkinson, James Biddle; and conflicts of interest search
- Winters, Elisha; Ark. landholder search
- Winters, Gabriel; Ark. landholder search


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Is a little sin such a bad thing?
Back from holiday, I have absorbed Europe's disgusting lack of hysteria about sexual matters. But here the obsession still rages
AS WE flew back to Britain on Sunday I knew that a culture shock awaited us. "Put on your jacket," I said to Alexander. "It will be cold outside." It was. And I don't just mean the weather. In the course of a week, we had adopted the mores of our holiday surroundings, where all transactions, however trivial, begin and end with a formal greeting by both parties. What's more, we had seen no news of the outside world — nothing but the headlines in Corse Matin of forest fires and an occasional newsflash of the Olympics.
The effect of our sudden re-entry was to make our accustomed world seem, for a little while, impossibly exotic. I can't get used to the fact that the…