text:
I.R.F. / Aging news / Diseases /
Amyotrophic lateral sclerosis (ALS) is a relentless fatal paralytic disorder confined to the voluntary motor system.
Its prevalence is about three to five in 100,000 individuals, making it the most frequent paralytic disease in adults.
Although ALS can strike anyone at any age, generally the onset of the disease is in the fourth or fifth decade of life.
Common clinical features of ALS include muscle weakness, fasciculation, brisk (or depressed) reflexes, and extensor plantar responses.
Even though motor deficit usually predominates in the limbs, bulbar enervation can also be severely affected, leading to atrophy of the tongue, dysphagia, and dysarthria.
Other cranial nerves (e.g., oculomotor nerves) are usually spared.
The progressive decline of muscular function results in paralysis, speech and swallowing disabilities, emotional disturbance, and, ultimately, respiratory failure causing death among the vast majority of ALS patients within 2-5 years after the onset of the disease.
Pathologically, ALS is characterized by a loss of upper motor neurons in the cerebral cortex and of the lower motor neurons in the spinal cord.
Often, there is also a profound degeneration of the corticospinal tracts, which is most evident at the level of the spinal cord.
The few remaining motor neurons are generally atrophic, and many demonstrate abnormal accumulation of neurofilament, in both their cell bodies and axons.
To date, only a few approved treatments (e.g., mechanical ventilation and riluzole) prolong survival in ALS patients to some extent.
However, the development of more effective neuroprotective therapies remains impeded by our limited knowledge of the actual mechanisms by which neurons die in ALS, and of how the disease progresses and propagates.
ALS, like other common neurodegenerative disorders, is sporadic in the vast majority of patients, and familial in only a few.
The clinical and pathological expressions of ALS are almost indistinguishable between the familial and sporadic forms, although often in the former the age at onset is younger, the course of the disease more rapid, and the survival after diagnosis shorter.
The cause of sporadic ALS remains unknown, while that of at least some familial forms has been identified.
Although the identified gene defects responsible for ALS account for a minute fraction of cases, most experts believe that unraveling the molecular basis by which those mutant gene products cause neurodegeneration may shed light on the etiopathogenesis of the common sporadic form of ALS.
Genetic forms of ALS
Although familial ALS is often referred to as a single entity, genetic evidence actually reveals at least four different types that have been assigned to distinct loci of the human genome.
This review will focus on a form that is responsible for the disease in approximately 20% of all familial cases and that is linked to mutations in the gene for the cytosolic free radical-scavenging enzyme superoxide dismutase-1 (SOD1).
To date, approximately 100 different point mutations in SOD1 throughout the entire gene have been identified in ALS families, and all but one is dominant.
Many of these mutations lead to the substitution of an amino acid within regions of the enzyme with very distinct structural and functional roles.
It is thus fascinating to note that so many discrete SOD1 alterations share a similar clinical phenotype, even though the disease duration and, to a lesser extent, age at onset varies among patients with different SOD1 mutations.
Also astonishing is the fact that SOD1 mutations, which are present at birth and, by virtue of SOD1's ubiquitous expression, in all tissues, produce a rapidly progressive adult-onset degenerative condition in which motor neurons are almost exclusively affected.
Most of these mutations have apparently reduced enzymatic activity, a finding that has prompted investigators to test whether a loss of SOD1 activity can kill neurons.
It was unequivocally shown that reducing SOD1 activity to about 50% kills pheochromocytoma-12 cells and motor neurons in spinal cord organotypic cultures.
However, mutant mice deficient in SOD1 do not develop any motor neuron disease, and the transgenic expression of different SOD1 mutants in both mice and rats causes an ALS-like syndrome in these animals, whether SOD1 free radical-scavenging catalytic activity is increased, normal, or almost absent.
These observations provide compelling evidence that the cytotoxicity of mutant SOD1 is mediated not by a loss-of-function but rather by a gain-of-function effect.
Transgenic mutant SOD1 rodents unquestionably represent an excellent experimental model of ALS, one that has already generated valuable insights into the pathogenesis of ALS and opened new therapeutic avenues for this dreadful disease.
Hypothesis for mutant SOD1 cytotoxicity
Despite the explosion of ALS research engendered by the discovery of the SOD1 mutations, the actual nature of the gained function by which mutant SOD1 kills motor neurons in ALS remains elusive.
Multiple mechanisms have been implicated in the demise of motor neurons in ALS, but only a few may be directly relevant to the form linked to mutant SOD1.
For instance, the known free radical-scavenging function of SOD1 led researchers to believe that mutant SOD1-induced neurodegeneration was due to an oxidative stress.
This idea was, at least initially, received with enthusiasm due to the fact that a variety of markers of oxidative damage are indeed increased in ALS spinal cords.
Currently, it is thought that, if SOD1 mutants were to generate oxidative stress, they could do so by two distinct and not mutually exclusive mechanisms.
In the first mechanism, the point mutations would relax SOD1 conformation, hence allowing abnormal kinds or amounts of substrates to reach and react with the transitional metal - copper - contained in the catalytic site of the enzyme.
Among the aberrant substrates to be proposed are peroxynitrite and hydrogen peroxide, both of which can directly or indirectly mediate serious tissue damage.
In the second mechanism, it is speculated that SOD1 mutations are associated with a labile binding of zinc to the protein, and that, by having lost zinc, mutant SOD1, in the presence of nitric oxide, will catalyze the production of peroxynitrite, which can inflict serious oxidative damage to virtually all cellular elements.
Alternatively, mutant SOD1 cytotoxicity may result from the propensity of this mutant protein to form intracellular proteinaceous aggregates, which are a prominent pathological feature of several of the transgenic lines, and of various cultured cell types expressing mutant SOD1, including motor neurons.
As in other neurodegenerative disorders with intracellular inclusions, whether or not these proteinaceous aggregates are actually noxious remains uncertain.
Nevertheless, it may be speculated that their presence in the cytosol of motor neurons may be deleterious, by, for example, impairing the microtubule-dependent axonal transport of vital nutriments, or by perturbing the normal turnover of intracellular proteins.
Early on in the effort to determine the nature of mutant SOD1's gained function, it was discovered that transfected neuronal cells expressing mutant SOD1 cDNA were dying by apoptosis, a form of programmed cell death (PCD).
Morphology of dying motor neurons
In light of the presumed proapoptotic properties of mutant SOD1 observed in vitro, it may be wondered whether, in transgenic mutant SOD1 mice, dying spinal cord motor neurons would also exhibit features of apoptosis, whose morphological hallmarks include cytoplasmic and nuclear condensation, compaction of nuclear chromatin into sharply circumscribed masses along the inside of the nuclear membrane, and structural preservation of organelles (at least until the cell is broken into membrane-bound fragments called apoptotic bodies that are phagocytized).
In transgenic mutant SOD1 mice most of the sick neurons are atrophic, and their cytoplasm is occupied with vacuoles corresponding to dilated rough endoplasmic reticulum, Golgi apparatus, and mitochondria.
Sick neurons have diffusely condensed cytoplasm and nuclei and irregular shapes.
Although the actual type of this cell death remains to be determined, these dying neurons exhibit a rather nonapoptotic morphology with some features reminiscent of autophagic or cytoplasmic neuronal death.
Forms of PCD with morphological features distinct from apoptosis also exist, making it difficult to exclude the possibility that a nonapoptotic form of PCD underlies mutant SOD1-related cellular degeneration.
Thus, these findings suggest that, while degenerating neurons in both human ALS and its experimental models do exhibit some features reminiscent of apoptosis, the vast majority of dying cells cannot confidently be labeled as typical apoptotic.
Activation of apoptotic molecular pathways
More convincing approach to evaluate the role of apoptosis in ALS may be to determine whether the neurodegenerative process in transgenic mutant SOD1 mice, irrespective of the morphology of the dying cells, involves known molecular mediators of PCD, and whether targeting such key factors can affect the course of the disease.
In light of the presumed proapoptotic properties of mutant SOD1, it is tempting to suggest that the mutant protein may be a death-signaling molecule in itself, either directly, by setting in motion the PCD cascade, or indirectly, by interacting with a variety of intracellular targets such as trophic factors, Bcl-2 family members, or even mitochondria.
Mitochondria are a particularly appealing target, because they not only contain mutant SOD1 but are structurally and functionally altered in transgenic mutant SOD1 mice, and because they play a pivotal role in PCD.
Once the mutant SOD1-mediated neurodegenerative process has been initiated, several secondary alterations develop in spinal cords of transgenic mutant SOD1 mice, including microglial cell activation and T cell infiltration, both of which may release a plethora of cytokines and other pro-PCD mediators.
Accordingly, while the nature of the initial death signal in transgenic mutant SOD1 mice remains elusive, in a more advanced stage of the disease the increased expression of several extracellular inflammation-related factors such as IL-1β, IL-6, and TNF-a may amplify the death signals that are already reaching motor neurons in this mouse model of ALS, by activating death receptors such as Fas.
IL-1β content is also elevated in human ALS spinal cords.
Key molecular components of PCD are recruited in ALS.
While precious data on PCD in ALS have been obtained thanks to the study of postmortem human samples, information regarding the temporal relationships of these changes and their significance in the pathological cascade emanates essentially from the use of transgenic mutant SOD1 mouse models.
In light of the above-described PCD-related changes, it would appear that this active form of cell death is not the sole pathological mediator of cell demise in ALS but rather one key component within a coalition of deleterious factors ultimately responsible for the degenerative process.
However, the actual relationships between mutant SOD1 and the various other presumed culprits represented by protein aggregates, oxidant production, and PCD activation are still unknown, and a better understanding of the pathogenic cascade in ALS will require their elucidation.
In scientists' opinion, one of the most important take-home messages is that apoptotic morphology should not be used as the sole criterion of whether molecular pathways of PCD have been recruited.
Indeed, scientists cannot stress enough that the PCD molecular pathways may be activated in a neurodegenerative process such as that seen in ALS, even when the prevalent morphology of the dying cells is nonapoptotic.
Apart from the question of whether the morphology of dying neurons in ALS is apoptotic, but still relevant to this discussion, is the contrast between the paucity of morphologically identified dying cells and the rather robust spinal cord molecular PCD alterations.
How can this striking discrepancy be reconciled?
First, it is possible that the morphological expression of PCD is much more ephemeral than its molecular translation.
Therefore, since in ALS the degenerative process is asynchronous, small lasting differences in the expression of these markers may have significant impact on the total number of cells that exhibit a given marker at a given time point.
Second, it is also possible that, since apoptotic morphological features are confined to the cell body while PCD molecular alterations may be found not only in cell but also in cell processes, axons, and nerve terminals.
Thus, the detection of PCD morphology may be much more challenging than the detection of PCD molecular events.
Third, the molecular tools used see not only the rare cells that are truly dying but also the numerous sick cells that may or may not ultimately die and that thus may or may not show the typical apoptotic morphology.
Another important point that derives from the work in transgenic mutant SOD1 mice is that not only neurons but also glial cells appear to be the site of PCD-cascade activation.
This observation does not undermine the potential pathogenic role of PCD in the ALS death process, but it raises the possibility that PCD may not only kill neurons in this disease.
However, since SOD1 is expressed in all cells, not only in motor neurons, it is possible that the activation of PCD in both neurons and glia reflects the ubiquitous nature of the mutant protein expression.
Whether PCD is also activated in neuron and glial cells in the forms of ALS that are not linked to mutant SOD1 is unknown at this point.
Clearly, the overall mechanism of neurodegeneration in ALS is still incompletely known.
Nevertheless, the available evidence indicates that PCD is in play in ALS and thus warrants further investigation of the role of the PCD cascade in ALS pathogenesis and treatment.
The most effective therapeutic strategies tested so far in transgenic mutant SOD1 mice target very distinct molecular pathways.
Scientists can therefore imagine that, ultimately, the best therapy for ALS will come from a combination of several interventions and not from a single treatment.
In keeping with this view, unraveling the sequence of key PCD factors recruited during ALS neurodegeneration should enable scientists to identify the most significant molecules to be targeted by this therapeutic cocktail to produce optimal neuroprotection.


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subset: commoncrawl


text:
"I'm not so bad myself," I said.
Tuesday, February 14, 2006
"I'm not so bad myself," I said.
4 Comments:
- Cibbuano said...
It's a hog-eat-hog world; you gotta compliment yourself.
Sometimes, just telling a girl that you're a looker will throw them off. They'll think 'Whoa! Is he?' and maybe fall for your wily wiles.
- Andiar said...
The trick with girls is to not give a fuck and shoot from the hip at all times. "I'm great." "She's fat" "You're average taste in music is actually above average because you're a girl." And so on. Until you find the right moment when you tell a fake story to make yourself look caring and sensitive. It's all gravy after that.
- Ben said...
Hot Indian Girl, after insisting that she pay for the movie at Blockbuster: "Wow, you're a cheap date!"
Me: "And I'm easy too!"
Cashier guy: "Dammit I hate my life and my fat non-hot non-Indian girlfriend."
- Madge DoRightly said...
The trick with guys is to not give a fuck and shoot from the hip at all times. "I'm really hot" "I'm smart, but not TOO smart" "Your taste in music is Dave Matthews and Django Walker, but I'll overlook that since your so nice and un-shitty"


text:
To Thomas Jefferson from Thomas Paine, 20 October 1793
From Thomas Paine
Paris,1 20 Oct., 1793.
I wrote you by Captain Dominick who was to sail from Havre about the 20th of this month. This will probably be brought you by Mr. Barlow or Col. Oswald. Since my letter by Dominick I am every day more convinced and impressed with the propriety of Congress sending Commissioners to Europe to confer with the Ministers of the Jesuitical Powers on the means of terminating the War. The enclosed printed paper will shew there are a variety of subjects to be taken into consideration which did not appear at first, all of which have some tendency to put an end to the War. I see not how this War is to terminate if some intermediate power does not step forward. There is now no prospect that France can carry revolutions into2 Europe on the one hand, or that the combined powers can conquer France on the other hand. It is a sort of defensive War on both sides. This being the case, how is the War to close? Neither side will ask for peace though each may wish it. I believe that England and Holland are tired of the War. Their Commerce and Manufactures have suffered most exceedingly—besides3 this, it is for4 them a War without an Object. Russia keeps herself at a distance.
I cannot help repeating my wish that Congress would send Commissioners, and I wish also that yourself would venture once more across the ocean, as one of them. If the Commissioners rendezvous at Holland they would5 know what steps to take. They could call Mr. Pinckney to their councils, and it would be of use, on many accounts, that one of them should come over from Holland to France. Perhaps a long truce, were it proposed by the neutral powers, would have all the effects of a Peace, without the difficulties attending the adjustment of all the forms of Peace. Yours affectionately,
Thomas Paine
MS not found; text reprinted from Moncure D. Conway, ed., The Writings of Thomas Paine, 4 vols. (New York, 1894–1906), iii, 134. Another printing, in Foner, Paine description begins Philip S. Foner, ed., The Complete Writings of Thomas Paine, New York, 1945, 2 vols. description ends , ii, 1333–4 (derived from a MS identified as being in DLC: TJ Papers, though the Editors know of no other evidence corroborating this location), includes the salutation "Dear Sir" as well as variations in paragraphing, capitalization, spelling, and wording, only the last being noted below. Recorded in SJL as received 31 Mch. 1794. Enclosure not identified.
1. Word not in Foner.
2. Foner: "through."
3. Foner: "and besides."
4. Foner: "to."
5. Foner here adds "then."


text:
This program teaches mediators specialized skills and techniques for working with adult families facing issues related to aging — such as living arrangements, caregiving, driving, family communication, medical decisions, Powers of Attorney / Health Care Proxies / Guardianship / Conservatorship, financial planning, estate planning, will contests, family real estate, and personal property distribution.
Join trainers Arline Kardasis and Crystal Thorpe, with guest experts from the fields of elder law and gerontology, for three days packed with content, skill-building, role plays, and opportunities to interact with fellow participants (who often travel from around the world to attend). For more information about the training and to register in time for the September 15 early registration discount deadline, click here.
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User:Brian P. Josey/Notebook/2010/06/07
|Project name
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Previous entry Next entry
Continuing from Friday
I am going through and running my calculations from Friday. So far, it appears that magnetizing a needle and placing it into a solution of ferritin is not as promising of an idea as I had hoped. The main issue is that the field is much weaker than when using the large yoke, and the effective range from the needle is very short. This might be advantageous, in that I could directly control a very small area, or not.
I choose a sewing needle over a syringe to capitalize on the solid volume, and thus greater magnetic moment, of the solid needle. I also skipped over a wire to take advantage over the sharp tip of the needle. Creating my model, I simplified it, running it twice, once with a 52 MGOe neodymium magnet, and another time with a 32 MGOe magnet. The 52 MGOe serves as the upper limit of what I can expect, and the 32 serves as a better approximation of a magnetized needle.
{{#widget:Google Spreadsheet
The above table is the values I recorded for the forces a magnetized needle would exert on a single ferritin protein, I used my usual notation for the sets of data, namely the top three go vertically from the tip of the needle in increasing distance, and the horizontal is what I expect if I held the cover glass of a flow cell against the tip of the needle. The issue here though is that not all of the points are really relevant beyond demonstration. The key points of data are those nearest to the tip, which represent ferritin floating freely by the needle. As the numbers show, it is clear that the needle comes nowhere near the force of the yoke, and small size of the needle dramatically reduces the force. For the 32 MGOe needle I ran two simulations. The first, like the 52 MGOe model, was as close of a representation of a #12 sharp needle as I could create. Needles of this type thicken from the tip to about a third of the way down. This slowly leaks out the magnetic field. The second one, featured a much sharper tip that comes form machining, did not allow as much field escape. Here is a side by side comparison:
Note to self the distances for indexing in the FEMM analyzer code are:


text: Guys, am I the only one who is fed up with ignorant people like the person who made that thread in the video section? I only have one question. Do they consider it fun to be ignorant? I am like really serious. Do ignorant people do ignorant things because it's "fun" for them or because it isn't fun for others. BTW I don't know how to report someone so can somebody do it for me? It's the member "IHATEOLDPEOPLE".


text:
While the Civil Rights Act of 1964 granted equal rights for people despite their gender or race, discrimination persists in the work place in Michigan and elsewhere. Women, in particular, may face hurdles during their course of employment that men do not, such as becoming pregnant. This simple act of starting or continuing a family can garner employment problems or even discrimination, but new federal guidelines seek to combat that.
EEOC update provides protection from pregnancy discrimination
Man says he suffered retaliation after seeking FMLA leave
A healthcare crisis cannot only take a serious toll on an individual's personal life, but it can also interfere with their ability to fully function at their job. Fortunately for most, the Family and Medical Leave Act provides some relief to individuals who work for qualifying employers. After a man claimed that he suffered retaliation after his employer violated the FMLA, a federal court that covers various states, including Michigan, agreed with him.
Civil rights violations at Michigan hospital led to settlement
In 2002, a study published by Johns Hopkins University documented that patients strongly prefer doctors that are the same race as themselves. A later study asserted that most African Americans felt that racism existed throughout the healthcare system. Several years after that study was released, an African American nurse experienced civil rights violations occurring at her own Michigan hospital.


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If you follow me on Facebook or Instagram you may have noticed that I have recently become a #GirlGains Ambassador!!! Super excited to say the least!! I have attended two of their amazing events and loved every minute of them, as an Ambassador it will be my job to bring these events closer to home.
You may not know what #GirlGains is all about so I caught up with Tally Rye, one of the co founders (the other founders are Zanna Van Dijk and Victoria Spence) to ask her some questions to explain what the #GirlGains movement is all about;
1. What is Girl Gains?
Girlgains is an online movement, created for women by 3 best friends Tally, Zanna and Vicky. We aim to empower girls all over the world to be the fittest, healthiest and happiest version of themselves. We started as a hashtag, predominantly on Instagram, but now we are bringing it to life! Over the past year, we have hosted numerous events in London and Manchester to unite like-minded women, build a support network and create real life friendships.
2. What made you get into the health and fitness industry?
We believe in following your dreams and pursuing your passions. Each of us soon realised that our 'hobby' had soon turned into a passion and a career path that we couldn't avoid. The way things have developed over the last 12 months, it often feels like fate!
3. What are your top tips for being motivated?
Give purpose to your training! Set yourself short term, mid term and long term goals. That way you always have something to work towards and when you accomplish them, it feels incredible!
We also encourage you to make your lifestyle social - make workout dates with friends or healthy brunch dates on the weekend. This way these healthy habits soon become a fixed part of your routine.
4. How often do you train and how much cardio and weights do you do?
Each of us is different! Speaking for myself (Tally), I train weights 4-5 times a week with 3 cardio sessions. This isn't super strict, as I often have to be flexible due to my often hectic work life.
5. Who inspires you?
All 3 of us look up to strong business women in the fitness industry who are truly making their mark. Claire Finlay of Transition Zone is a remarkable woman, as are Pip & Joan the founders of Frame. And without a doubt, we each inspire each other every day! To work harder, to be more ambitious and to believe in ourselves.
6. What are your favourite snacks to have when feeling peckish?
You can't beat a Quest Bar on the go! They're a bit of handbag staple for all of us.
7. What are your current fitness goals?
All 3 of us are heading out to Sierra Leone at the end of May to run 10K with the charity Street Child - so being ready to run in that heat is certainly our priority right now!
To find out about upcoming events, give their website a visit, hope to see you all at an event in the very near future.
Aishlen xo


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Alternative Titles
Japanese: グリーンレジェンド乱
Type: OVA
Episodes: 3
Status: Finished Airing
Aired: Nov 25, 1992 to Mar 25, 1993
Producers: AIC, Pioneer LDC
Licensors: Sentai Filmworks, Geneon Entertainment USA
Studios: None found, add some
Source: Original
Duration: 45 min. per ep.
Rating: R - 17+ (violence & profanity)
Score: 6.871 (scored by 1,329 users)
1 indicates a weighted score. Please note that 'Not yet aired' titles are excluded.
Ranked: #39562
2 based on the top anime page. Please note that 'Not yet aired' and 'R18+' titles are excluded.
Popularity: #5265
Members: 3,352
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Very Fine in Fine jacket. Signed by Author Ltd. Edition to 1000 copies. Original SIGNED Print by Emmett Williams. Boxed. Dustjacket in mylar. Mr. Williams was born in S. Carolina, but lived and worked in Europe between 1949-1966, and was editor-in-chief of the Something Else Press from 1966-1970. In the fifties, he became closely involved with the European intermedia avant-garde, epitomized by the 'darmstadt circle'; in the Sixties, he was an initiator of fluxus, an int'l post-dada, mixed means movement. His writing reflects the experimental tradition in the non-literary arts.
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text: My bride and I have been coming here for more than 15-years in the off-season and our extended family rents the Upper Walnut for maximum space for a week each summer for the last 10 years, so I'm biased. I love the place, it's like home. Having all the amenities that large families love at a family resort, well, there's... More


text:
With grateful thanks to Marta McDowell, for bringing us such a delightful book.
Here are a few photos from its pages.
What a gorgeous book, Denise! What a treasure for a pre birthday treat. :)ReplyDelete
What a great post! I have feasted on the cozy art and words of Beatrix Potter for years and years since childhood and eventually shared the delightful art and stories with my daughter when she was little. This book appears to give a well-rounded view of the author/artist … I have always thought of her as energetic and sturdy. As someone who could dissect animals in quest of understanding anatomy, she also had a healthy pragmatism about the life in her garden.ReplyDelete
Oh my GOSH!!! I am going to Amazon straight away and buying it! We love Beatrix, and have her complete stories. I also watched a movie on her life. Thanks so much, I am off to buy it now!!!ReplyDelete
Done! I just bought it. Can't wait!ReplyDelete
my favor tie page of the ones you showed us is the one with the drawings of chickens and cats.. what a find.ReplyDelete
Lovely book you have there.ReplyDelete
Hello Denise, what a lovely birthday gift.. I have enjoyed Beatrix's stories too! Enjoy your new book! Have a happy week!ReplyDelete
What a beautiful, beautiful book.ReplyDelete
Looks like a great find, Denise!ReplyDelete
Oh yes I love Beatrix also, although I didn't know her as a child. I read her books to my kids while I read mostly American authors as a child. Exceptions were 'The Secret Garden' and the Mother goose stories. Mom read Robert Louis Stevenson's poetry, including "The Land of counterpane" to me when I was sick. Mom also loved Robbie Burns and quoted him frequently. Now I've had another memory bubble, thanks to you. Great post!ReplyDelete
Jane x
What an amazing coincidence. The smaller portion, knowing my love of Beatrix Potter, gardens and biographies gave this book to me. It is lurking in my unread tower - and getting closer to the top.ReplyDelete
I really love all things Beatrix Potter. Might have to put this on my list...ReplyDelete
What a fine gift!ReplyDelete
How lovely!ReplyDelete
Beatrix Potter is certainly a classic.ReplyDelete
That looks like a wonderful book...think I will check the libraries to see if either have it.ReplyDelete
Hello Denise, I found this post via this n that, and I soon as I spotted Beatrix Potter and gardening in the same title I was hooked! My family come from very close to where Beatrix spent her life in the Lakes, and though I now live in Australia, there will always be a place in my heart for her books. This one looks great and I am certainly going to try and get hold of a copy. Thank you so much, JaneReplyDelete
Made for you!
ALOHA from Honolulu,
When I was a kid I couldn't get enough of the Beatrice Potter characters. She wrote such fascinating tales. Did you see the film about her?ReplyDelete
What a wonderful post about a delightful book. I know little of Beatrice Potter or her works but you've got me interested so more reading ahead of me now.ReplyDelete
How very interesting!! You have a treasure there.ReplyDelete
Wonderful addition to your library -- I've never outgrown Beatrix and now that even my great-grandsons are past the age of wanting to hear these books read aloud I miss her! I'd love to read this book.ReplyDelete
Such a beautiful post and wonderful book and 'pre-birthday-treat' for you Denise!!!
It's on my wish list now :)
I have a movie about her life and her work...She was such a talented and creative woman and her tiny characters are so, so cute!
Enjoy this treasure and also beautiful, warm and sunny spring days :)
What a beautiful book!ReplyDelete
I saw the movie Miss Potter and really enjoyed it. She was really an amazing person!ReplyDelete


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Lewis and Clark College basketball tournament
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Find info concerning Lewis and Clark College basketball tournament, and registering for elective seminars and discussion sections. Not all recruiting is done like NCAA Division I teams. College coaches are constantly looking for the best players to fill next year's open positions, and rely on many different methods to finding the right recruits. If you haven't been noticed, cold-calling coaching staff can get you an initial interview. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Lewis and Clark College Basketball information. Please use the form above to request admissions info for Lewis and Clark College.
Always maintain a positive attitude, especially when you're in pain, or losing a game. Be a good sport, and keep trying. Believe you'll be successful, act like you can still win the game, and then go out and make it happen. Be aggressive, and make a second try on a given play if you have time. It's one thing to make a good effort, but great players keep trying until they succeed, no matter how many years of team practice that takes.
If you get lazy, and decide to take it easy during practice, coaches will take notice. Push yourself, work hard, and you'll improve as a player. It's important to find a position that you really like to play, not just settle for what you're good at. Over the long haul, you'll have a better athletic career. Kellogg Community College indoor track and field may encourage student-athletes to apply via early decision. Students who are considering applying via early decision should be aware of the rules and obligations that this commitment entails. Beyond consideration for Lewis and Clark College basketball tournament, you may think about Birmingham-Southern College initiatives for complementary electives to your primary course of study.
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Product Description
A lovely, inexpensive, and practical table lamp to meet your basic fashion lighting needs. This mini globe lamp features a ceramic base and matching fabric shade. Perfect for living room, bedroom, office, kids room, or college dorm!
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On 22nd August, 2011 Dahi-handi programme was celebrated. The Chairman of the Institute and the Director inaugurated the function and supported the participants for the game of Dahi-handi. Four groups were formed. It was an awesome experience for the student as well as faculty members. The evaluation of the game was been done on the Management Principles like as; Controlling, Directing, Organizing, etc..,
Winners of the event were awarded with I and II rank. Event was excellently design, organized & co-ordinated by Prof. Sudarshan Dahatonde.
Global Institute of Management celebrated teacher's day programme on 8th September, 2011. Honorable Director and some faculty member share their experience about the school and college life and explained the importance of Guru in our life. Students also expressed their opinion regarding importance of teacher to develop career as well as life.
As we know season of Ganesh Festival, and how the Global family members can be away from that festival. Global family members enthusiastically celebrated the Ganesh Festival from 1st of September, 2011 to 10th of September, 2011. Finally on 10th September Ganesh Visarjan was done.
Global is much more concern about the overall development of the students and to nurture them along with academics sports committee organizes various sports events like Cricket, Volleyball, Chess, Carom. Students always enthusiastically participate in the sports and thus they can come to know the importance of the 'Team spirit and Team Play'
The basic intention of such activity is to make students more close to nature and also to increase the physical strength.
Students enjoyed the program and thus their minds were nurtured with nature's essence.
The program is the beginning of the new batch of MBA in the global family and to welcome them the program was organized on 1/10/2011.
Mr.P.J.Ubale Patil (Managing Director Rajhans Dudh) was the chief Guset for the program & Mr. R.K. Yewle (Chairman Dyanvardhini Shikshan Sanstha) was the Guest of Honour on the occasion.
Mr. P.J.Ubalepatil In his speech explained the various skills that a professional should possess also the importance of our attitude to learn the new things. Students enjoyed the day and it shows a binding of trust and respect.
On the eve of fesher Party various cultural Program like Fish pond, Singing, Dancing were orgnized.All students enthusiastically participated in program & enjoyed the event. Prizes were given to Mr. Fresh & Ms. Fresh along with toppers.
Global Institute of Management has organized the blood donation camp on 3rd November, 2011. Arpan Blood Bank, Sangamner was called to conduct the camp. Blood donation was started at 10.00 am and response was excellent as student and faculty participated along with one of the guardian. A lecture was conducted by the blood bank which explains the importance of blood donation and its benefits to the donors and society. Certificate was issued to the donors. They also gave trophy to the Institute for such a helpful deed.
All Global family members participated in complete programmes and whole day was enjoyed by all the members.
Global Institute of Management celebrates birthdays of student as well as faculty members and Non-teaching staff on every month on specific day. Under the guidance of the event co-ordinator students make the arrangement of Birthdays and it is been celebrated in Seminar Hall with great pleasure and joy.
Parent meet was held on 3rd Nov 2011 in the conference hall of the Global Institute of Management, Sangamner. It was the first parent meet organized by the institute. The program begun with deep prajwalan and parent were welcomed by Global family members.
Dr. B.B.Jadhav, director of the institute explains the various achievement and future program of the institute. He also provide information regarding the various program conducted by the institute just like industrial visit, carrier guidance, placement, cluster -2011, etc which has create a hall mark of success.
Parent also expressed their views and shows confidence regarding the institute. Some students of Global were honored due to their extraordinary work.
The cultural program 'Rythem 2012' has provided the platform to present the skills and arts of the students. Program was very successful. Students enjoyed a lot.


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Adopt the French attitude
Assortment of biscuits filled with chocolate, chocolate covered almonds, chocolate caramels, and traditional nougats.
About the Brand...


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{All photos (except the last) courtesy of the Southern Cultural Heritage Foundation}
Over the River Run in Vicksburg
This Saturday, October 11th at 8:00am, the Southern Cultural Heritage Foundation will host the 26th annual "Over The River Run" in Vicksburg! This historic, scenic race takes place on the handsome Old Mississippi River Bridge. Participants in the 5-mile race will enjoy sweeping views of the Mighty Mississippi as they cross the river into Louisiana.
The striking landmark was built in 1930, but was closed to vehicular and pedestrian traffic in 1988. Listed on the National Register of Historic Places in 1989, the Old Vicksburg Bridge still proudly carries the Kansas City Southern Railroad across the river.
Stacey Massey, Executive Director of the Southern Cultural Heritage Foundation says, "You can participate in the 5-mile walk or 5-mile run, and we have a 1-mile fun run for the kids! Crossing the bridge into Louisiana is spectacular; it is just beautiful running over the river."
Following the run, a family-friendly party will be held in downtown Vicksburg. Enjoy delicious refreshments, inflatable surprises for children, and live entertainment by "Slaphappy!" The American Massage Therapy Association will also be on hand, relaxing sore muscles after the 5-mile race.
The Southern Cultural Heritage Foundation is celebrating its 20th anniversary this year. The non-profit was formed to preserve an entire block of historic buildings in downtown Vicksburg, and transform them into a cultural center. Their mission is to continue preserving these gorgeous structures while offering wonderful events to the Vicksburg community.
What a fantastic autumn event for the entire family to enjoy! To register for the race, please visit southernculture.org, click here, or call 601-631-2997!
{Blog by Mitchell Walters}
{All photos (except the last) courtesy of the Southern Cultural Heritage Foundation}
Comments are closed.
September 2017


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Business TypeOther
Main MarketsSoutheast Asia
Product/ServiceMassager, Health Care Products
Business Owner
EmployeesLess than 5 People
CategoryHealth & Medical - Health Product Agents
Company TagsAustralia - Established - Fitness Industry - Health Care Products - Health Industry
Company Introduction
VDS International has been operational since 1994 established to supply solutions to the manufactoring industry within Australia, now VDS International is diversifing into the health industry as members of the company have many years of involvement in the health and fitness industry.
Contact Information
Contact PersonMr. Fred Vandersteen
Fax Number61-03-59683173
Post Code3782
Address2 Albert Rd, Emerald, Victoria, Australia
Online MapVDS International Map & Directions


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Leaders and letters
Saturday 9 September 2006
Peter Stowe: South Pennines
Letters: The arrogance of Tony Blair in apologising for the Labour party is breathtaking (In public, apologies and harmony. In private, fury, September 8).
Letters: Having supported Labour ever since 1945 (despite Iraq), but never as a party member, I will now seek membership to vote against Gordon Brown. Renewal of the "nuclear deterrent", reintroduction of nuclear power, student fees, shameful treatment of the old, ridiculously unfair council tax, income tax at 40% for the seriously wealthy?


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Pourquoi le cycle de Deming contribue-t-il à une meilleure gestion de la sécurité
Diving involves a rigorous series of checks and systems to ensure the divers safety combined with a practice of continued improvement. In this French Language analogy Fabrice De Paepe takes a look at what we can learn from this in our own approaches to Information Security.
Many Bands Make Light Work
The original Band Aid was successful because Bob Geldof and Midge Ure recruited the best musicians of the time together for the greater good. Dan Raywood looks at whether this could provide a similar blueprint to help further the InfoSec cause.
Find Me Those Plans….
Adrian Davis takes a look at Star Wars and what lessons we can learn from the theft of those Death Star plans…
God Save Me From My Friends. I Can Protect Myself From My Enemies
It's often our friends and family that can hurt us the most. Yotam Gutman takes a look at how this often the case within our organisations.
Rollen som analytiker
This is the Danish version of 'The Role of the Analyst: Infosec Librarian and Curator', first published on the 27th October. Looking at the role of Librarians and Museum Curators, Claus Houmann demystifies exactly what a Security Analyst is.
The Changing of the Seasons
Brendan Byrne takes a look at how we can reduce the disruption the weather causes as the seasons change and ponders whether we can look at security seasonally within business


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Benefit held for Griffith's family
Sally Mateyak, mother of Kimberly Griffith, sheds tears as she read memories of her daughter and grandchildren.
A dinner benefit was held recently at the La Dolce Casa Restaurant in Tamaqua for the Griffiths family, which was hit with tragedy during a flash flood in Pittsburgh.
Tamaqua native Kimberly (Mateyak) Griffith, 45, of Plum, Allegheny County, and her daughters Brenna Griffith, 12, and Mikaela Griffith, 8, died in August when their minivan became submerged in water so deep that would-be rescuers floating in a boat directly above it didn't know it was there.
The benefit, which included food, drinks, speakers and singers, was organized and held courtesy of restaurant owner Alfonso Picone, who donated all proceeds from the dinner to the family.


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|Having Fun and Getting Strong!
Last week, quite impulsively, I decided I would try it, and GUESS WHAT?
It was fun!
In fact, it was so fun I went again, today! I am stronger than I think.
One of the things I have challenged myself to, is finding joy in being sober.
I believe that this is one of the most important things I can do to keep from drinking again.
I will be in danger if I only feel sorry for myself that I can't drink, or thinking I am missing out.
For me, joy and gratitude go hand in hand.
If I am not thankful, it is harder for me to be joyful.
I find that I must cultivate optimism. I don't always have this mind set.
Sometimes I think, "What is life really about...I only have maybe 20 years left to live."
That is scary!
So along with optimism, I try to laugh at myself.
Maybe I have more like 29 years to live, considering my mom is 92!
Helping other people in recovery is helping me find joy.
I helped a busy mom from my AA group, who had just moved, unpack boxes and fold laundry.
This one little act made a difference in my attitude that day. I was so content.
Acceptance is part of my joy.
When I accept things as they are, I am far more joyful than when I am wishing everything was different, or I was different.
I realize this is a journey. Every time I think I haven't made any progress or that I am stuck, I realize I have made changes. Good changes.
I found this website that has some good information about finding joy.
I have posted a part of the article below, but the full article is here: Alcohol Rehab
How to Find Joy in Recovery
Establishing a joyful life in recovery usually involves a bit of patience. There will be many moments of joy right from the early days of recovery, but it can take a bit longer before the individual feels more fully happy with their life. The individual is able to find happiness in sobriety by:
1. Having realistic expectations. Expecting too much right away is probably going to lead to disappointment.
2. It is important to keep in mind that joyful living does not mean that people walk around with a constant smile on their face – it just means that for the majority of the time they feel content with their life.
3. In order to create a fulfilling life in recovery the individual will need to put some effort into it. Just giving up their addiction alone is unlikely to be enough.
4. Once people become physically sober they need to begin working on their emotional sobriety. It is this that will lead them to true peace and happiness.
5. Many people find that joining a fellowship can help them establish a more successful sobriety. This way they can benefit from a program and the experience of people who have gone before.
6. Other individuals may find that therapy helps put them on the right path in sobriety.
7. It is highly recommended that people maintain a beginner's mind in recovery. This means that they do not allow their preconceived beliefs, opinions, and ideas to get in the way of helpful advice.
8. Those people who are most successful in sobriety are willing to take risks and try new things. It is always good to develop the willingness to try new things.
9. Sticking with the winners is very good advice for anyone who hopes to build a strong recovery. Those individuals who have already made their own recovery successful tend to be inspirational and a source of good advice.
10. When people achieve their dreams in recovery it can increase their sense of well-being.
11. Techniques such as mindfulness meditation can be wonderful for helping people develop emotional equanimity. The meditator investigates their own inner world and they develop much greater understanding as a result of this.
12. Joyful living is often all about perspective. It means viewing challenges as a chance to grow and failures as a chance to learn.
|New Shoes... I Feel Like a
Kid Again!
13. Joy is not to be found in self obsession and selfishness. Sharing and thinking about others is what really leads to happiness.
With A Cup of Coffee,
New Shoes,
And Joy,
On Day 967,
New Shoes,
And Joy,
On Day 967,


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Monday, 1 September 2014
Loose watercolour sketches
I'm having fun with some loose sketches
using my new Spacetec pen
and Watercolours
~ Wild Geraniums in our garden ~
~A vase of roses ~
Although these are only sketches, I do feel they would
be good as full watercolour paintings framed.
Sketching them first is a great way to find out
if they would work.
12 comments:
They definitely would work. Lovely!ReplyDeleteReplies
Aww, thanks CJ, that's nice to know :-)Delete
Ann, so lovely art works!! Also, I visited your art community. Wonderful. Have fun there, too. Best wishes, SadamiReplyDeleteReplies
Thanks very much Sadami :-)Delete
It is so good to try new things, be a 'loose' woman...I mean artist! Hope you don't mind my silly joke! I love what you've done and think it would beReplyDeleteReplies
I've always been a loose woman Mrs. A, lol.....just keeping to character :-)Delete
I don't think these should be called 'sketches' they ARE watercolor paintings! ♥ReplyDeleteReplies
Aww, Thanks Robin....:-)Delete
very beautiful!ReplyDeleteReplies
Thanks Christine :-)Delete
I love the soft, flowy colors!ReplyDeleteReplies
Thanks very much Debra :-)Delete
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If you are looking for a feature-rich and professional open source e-commerce platform for your online store, Magento will definitely the first name that strikes the head. In this article, I will show you top 6 impressive features of a Magento website that make you satisfied. As you know, Magento is the ultimate e-commerce solution that offers flexibility, functionality and great user experience on your site. There are a variety of tools that can help you in making an e-commerce website and with Magento, the platform will bring it all for you. This approach to programming is mirrored in the way you will develop themes for your store. especially in Magento 2 Store Locator plugins
Moreover, the latest version Magento 2 has elaborated the shopping and admin features making it more user-friendly. These are 6 impressive features that an e-commerce website development company can benefit. Let's take a look:
1, Open Source Platform
Firstly, Magento is an open-source eCommerce development platform, so merchants can access added features by installing extensions and themes from the huge Magento Connect marketplace. It is also the most favorited e-commerce platform by most by the companies providing web application development services. According to a research recently, more than 80% eCommerce websites are based on Magento CMS and are performing world-class when it comes to generating the revenue.
2, Optimized for SEO
The second feature is that Magento comes with built-in SEO tools that help search engines crawl the website pages and automatically improve its ranking on the search result pages. Magento 2.0 is competitively packed with powerful SEO features that allow merchants to increase traffic to their websites and product pages.
3, Internationalization support
I can not mention the outstanding feature of Magento is that there is a large community of Magento users. It is one of the most used e-commerce platforms in the world so if you have any problems, your website can receive support very quickly because there are countless resources to solve problems. In addition, the large community has inspired to develop many extensions and plugins. Support for localization, multiple currencies, and tax rates. Support for accented characters and right to left text. Configurable list of allowed countries for certain features. European Union VAT-ID validation, EU cookie notification,...
4, It provides a large number of impressive features
Next, Magento has a wide range of features which allows us to manage multiple stores and support multiple locations, multiple language, multiple pricing and multiple currencies and it is considered as one of the most impressive features of a Magento website. Compare Magento to other e-commerce platforms like Shopify, Woocommerce, it stands out with its abundance of features. For instance, with the help of Magento, you can vary your price of the specific product depending upon the group of customers. You can fix a different price for your staff as well as a different price for VIPs.
5, Quick Checkout With One Step Checkout Extension
Thank this extension, the checkout process has become much simpler and faster. Fewer steps for your customer to modify means they will more likely complete the full checkout process. It expands all checkout steps and displays them on one page so that your customers know in advance what fields they would have to fill out. This increases trust and significantly reduces cart abandonment. Quick Checkout system allows users to easily checkout without any hesitation. There are many different admin options available so you can modify the checkout process to fit your needs.
6, Magento app development
Magento was responsive in different types such as iPhone, iPad and Android devices. It consists of two parts: a Magento web store with an XMLConnect extension installed and configured, and a native application itself. The Magento platform invariably integrates with mobile app giving the shoppers the best experience for shopping anytime from anywhere.
In conclusion, with top 6 impressive features of a Magento website that I mentioned above, it is not surprised that Magento has become the most popular and most-liked e-commerce platform.


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Tuesday, March 15th, 2011 at
5:08 am , filed under
Celebrities by
Selena Gomez was not happy as she was leaving the LAX Airport. Reportedly, she is upset of Justin Bieber's bad behavior.
Selena Gomez, the Disney star and alleged girlfriend of Justin Bieber seems not at all happy, while she was leaving the LAX Airport on March 13, 2011. Reportedly, she is not happy with bad behavior of her boyfriend.
As per the sources, Justin Bieber is losing his cool and getting frustrated, which is plunging him into controversies, which is upsetting his girlfriend Selena Gomez. Justin Bieber and Selena Gomez went for dinner on February 26, 2011. There he was spotted behaving rudely with some fans.
Also, he showed his middle finger to the paparazzi, while he was shopping along with Gomez on his birthday. The other day, he also attacked a woman carrying a camera. He attacked her, as she was trying to take his photo, while he was walking with Selena down the road. The sources add that, he kicked one of his backup dancers in the throat on March 4, 2011, while he was performing in UK during his 'My World Tour'.
According to the sources, he also stole the phone of his guitarist Dan Kanter and tweeted prankly saying that, he is leaving Justin Bieber, which caused a stir among the fans. Recently, as a part of his world tour, he did not zip his pants.
So, all these reasons and his attitude might be spoiling her mood and being distracted, because of which she is not happy.
Tags: Selena Gomez, Selena Gomez and Justin Bieber, Selena Gomez Not Happy, Selena Gomez Not Happy with Justin Bieber's Behavior


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Assets in exchange-traded funds around the world now surpass $1 trillion, soaring an astounding 45.2% from $710.9 billion at the end of 2008 to $1.032 trillion at the end of last year, BlackRock reported. By comparison, the return on the MSCI World Index in that timeframe was 27%, indicating that a good percentage of that growth was driven by inflows.
Currently, there are a total of 1,939 ETFs from 109 providers in the world trading on 40 exchanges.
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Better Feeding for Greater Health
We understand taking on the task of feeding can be overwhelming and stressful, especially for parents of children with limited eating habits or who demonstrate problematic behaviors when presented with unfamiliar foods. Our Feeding Therapy program is intensive and provides ongoing support for families while their child is moving along in their journey to enjoying more foods.
What You Should Know About Our Feeding Therapy Program
Our Feeding Therapy program is designed to increase the amount or type of food consumed by our learners. We understand:
- Children refuse food for many reasons, such as texture, color, type or simply because it is new.
- It is common for children to build strong preferences for the foods they do consume. These preferred foods may not be nutritional or could even be harmful if the child has food allergies or intolerances.
- Removing preferred foods can sometimes result in problematic behaviors, such as aggression, tantrums and property destruction, to name a few, behavioral therapy can help.
Our Feeding Behavior Therapy Program:
- Begins with an initial assessment of the learner's current food preferences, as well as the foods that are most commonly refused. Parents are a very important part of this process and will help guide the program's goals for overall food consumption.
- Following the assessment, the program will be tailored to the child's needs.
- Our therapists will implement the feeding program with close oversight from our clinical supervisors. We can hold sessions either in your home – which is recommended for more intensive cognitive behavior therapy sessions – or at one of our clinic locations. On average, we recommend at least two sessions per week. Depending on the type of feeding issue, our therapists present a non-preferred food with a highly preferred food. The child gets to access the preferred food when they take a bite of the non-preferred food. We shape up the behavior with the non-preferred food so they are not overwhelmed with having to take a bite of something "awful" the very first time.
- Data will be collected each session, and daily analysis of the child's behavior will drive the program to a successful completion.
- Parents will be trained on all behavior therapy procedures used to ensure that progress lasts over time.


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Product Description
Pair of Off Camber Fabrications 54" Roof Light Bar Mounting Brackets for all 2009, 2010, 2011, 2012, 2013, 2014 and 2015 Dodge Rams.
Are you looking for a way to mount that gorgeous new 54" light bar onto the roof of your 2009-2015 Dodge Ram? Look no further, because CJ has you covered! Order this Pair of Off Camber Fabrications 54" Roof Light Bar Mounting Brackets from CJ Pony Parts today!
Roof Light Bar Mounting Bracket Features and Benefits:
- 10 Gauge Steel base
- 12 Gauge Steel upright
- Low profile mounting style
- Allows for adjustable lighting positions
- Durable black powdercoat finish
- Fits a 54" straight roof light
- Sold as a pair
Each of these Off Camber Fabrications mounting brackets features a base made of 10-gauge steel along with a 12-gauge steel upright. They also have a black powder-coated finish that is resilient and durable to look great over time. Sold as a pair, these Off Camber Fabrications brackets will allow you to fit a 54" roof light bar on the top of your truck. The low profile mounting style of the brackets will create a unique look, while their adjustability will let you position your light how you specifically desire, creating a fantastic addition to your Ram's overall look & style.
Order this Pair of Off Camber Fabrications 54" Roof Light Bar Mounting Brackets for your 2009, 2010, 2011, 2012, 2013, 2014 or 2015 Dodge Ram from CJ Pony Parts today!
Similar Ram PartsMore Electrical & Lighting
Installation Instructions
Difficulty: Easy
Ram Applications
This product will fit the following Ram years:
- 2009,
- 2010,
- 2011,
- 2012,
- 2013,
- 2014,
- 2015
Product ReviewsWrite a review
Product Questions
Will this fit in a 2016 ram 1500 , with a curved 54inch light bar ?
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LED light bars are becoming very popular with truck owners because they give your truck great off-road visibility and a nice, aggressive look. If you want to mount a 54 inch LED light bar on your Ram, these mounting brackets are exactly what you need.
Made with a 10 gauge steel base and a 12 gauge steel upright, these brackets mount a 54 inch straight LED light bar on the roof of your Ram. With their low-profile design it gives your truck a nice aggressive look.
They are powder coated black to resist corrosion and can be found along with other parts for your Ram at CJPonyParts.com.


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SCTV: Galaxy 66 (1977)
Directed by George BloomfieldGenres - Comedy | Sub-Genres - Sketch Comedy, Variety Show [TV] | Run Time - 30 min. |
Share on
After the latest episode of "Diving for Dollars," soon-to-be station manager Edith Prickley (Andrea Martin) makes her debut appearance on "Sunrise Semester," pontificating on proper elevator conversation. Later on, Bradley Omar (Harold Ramis) -- who's still waiting for those flat TV screens to show up -- hosts "Sci-Fi Theater"'s feature presentation, "Galaxy 66," a picaresque journey through the highways and byways of space with those cool dudes Micron (Joe Flaherty) and Antaur (David Thomas). Also: host Marvin O'Shea (Harold Ramis) guides his short-attention-span guests through another session of the popular talk show "Beside the Point."


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Portion size is key!
Hey everyone, so I am currently on day 4 of my 12 week plan, and I've got to say... I'm LOVING it!
I feel so in control, I feel like I have more energy and I'm aware about what I'm eating and how much - without feeling hungry!
So I have downloaded a free app on my phone called "my fitness pal" and I really think that this is my saviour and my support for weight loss!
I can search, or scan bar-codes of everything that I eat or plan on eating, and the calories and nutritional information comes up. It adjusts to how many g's or ml's that you select.
I am finding this sooo useful. I have a set of kitchen scales that are now permanently on the counter, so If I fancy something to eat, I can scan it or enter it into the search bar on the app, find out how many calories it is (for example, 100g), weight it, and away I go!
You can enter these foods into a food diary that is on the app, for breakfast, lunch, dinner, and snacks. You set your goal weight, and how many weeks/months you'd like to reach it in, and it works out how many calories per day you need in order to reach that goal. You can also document weights, measurements, exercise and even photos to the personal diary... and its all free! It's a dream come true!
I hope this helps anyone who is struggling/who has not heard of this incredible, easy app - and I apologise to those who have heard it a million times! I just wanted to share it and help
Olive165 xx
Featured Content
Join the NHS Weight Loss Plan
Join over 40,000 others on our 12-week diet and exercise plan. Keep motivated to develop healthier eating habits & get more active.Get Started!
Featured by HealthUnlocked


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Donate or Volunteer
Memorial Tree:
The TCMCC Memorial Tree Program allows you to remember your loved ones by contributing to the quality of life of all of our residents. Not only will your loved one be honored with a leaf on one of the Donors' Memorial Trees, in the lobby, but if your donation is requested to be used for the purchase of a specific item, your loved one's name may also be engraved on a plaque mounted directly on that item. Memorial Donations have been used in the past for the purchase(s) of:
- Trees and shrubs for the facility's approved landscaping projects.
- Park benches and picnic tables for the various garden areas.
- Elevated planters to allow wheelchair access for residents who love to plant and maintain flower gardens.
- Wheel-chair accessible Picnic Tables for the Outdoor Pavilion.
- Memory Alcoves on the units, representing the various decades in which our residents have grown, lived or raised their families.
- Bird Aviaries, located on two units, where residents can enjoy the beauty and sounds of a variety of small birds.
For more information on our Memorial Tree Program, or to donate, please read our brochure or call (989)673-4117.
TCMCC Foundation:
TCMCC Foundation is a designated fund of the Tuscola County Community Foundation
With healthcare revenues supported by tax dollars becoming increasingly volatile, the TCMCC Foundation was established in 2014 to provide a stable supplement to operations, ensuring that future generations continue to receive high quality care.
For more information on how to donate please email email@example.com.
Mission Statement
The purpose of Tuscola County Medical Care Community is to facilitate a care-partnership among staff, residents and families that enhances the quality of life for all we serve. Further, to maintain a level of excellence among staff, exercise financial responsibility and adapt to everchanging needs of life's continuum.
Vision Statement
Tuscola County Medical Care Community will be the model for extended care services in the State.
What to Expect:
In exchange for your commitment to Tuscola County Medical Care Community, you will benefit in various ways. You will learn to grow, make new friends, develop new interests and skills, test career possibilities, find self-fulfillment, receive a sense of worth by serving residents. You will become informed of the purpose and function of Tuscola County Medical Care Community and be a part of the team of people who are concerned about the well being of those living at Tuscola County Medical Care Community. Volunteer Ideas: assist with group activities, give manicures, fold laundry, make beds, play instrument, read to residents.
Steps to Becoming a Volunteer:
- A prospective volunteer sets up an appointment to meet with the V.P. of Personnel.
- An application is filled out. You can print the application here. Please mail the application to Tuscola County Medical Care Community 1285 Cleaver Rd. Caro MI 48723.
- Application is turned in. Background checks are completed by the Personnel Department.
- The job that the volunteer chooses to do is discussed and the department where the volunteer will be serving is contacted and an appointment is set to meet the supervisor.
- A general orientation takes place.
- A tour of the building is included in the general orientation at which time people in the department where volunteer will be serving are introduced. The volunteer is also shown were the volunteer sign in sheets are kept and instructed how to fill them out.
- A TB test is given and the volunteer is directed to come back in 48-72 hours to have the test results read.
- A volunteer schedule is made.
Youth Program Requirements:
- Youth volunteer must be in 9th through 12 grade.
- Youth volunteer should be available a minimum of 2 hours per month. He/she may volunteer no more than 3 hours per day, and no more than 10 hours per week unless special permission to work additional hours is granted through the Personnel Department. Volunteer must be available a minimum of 6 months.
- Volunteer must have own transportation.
- Volunteer must be willing to have a TB test done.
- Volunteer must participate in any required training.
For more information on our volunteer program please contact our V.P. of Personnel at (989)673-4117 ext. 509


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S&W 65-3, Ruger Security Six, or Ruger Speed Six for carry?
View Single Post
December 10, 2012, 09:44 PM
Deaf Smith
Senior Member
Join Date: October 31, 2000
Location: Texican!
Posts: 4,397
First picture a M66-3 and M686-3 S&W .357.
Second picture a S&W 60 (no dash) and S&W 66-4 .357.
And third picture a S&W 640 with Secret Serivce stocks, Ruger SP101 DAO also with SS stocks, S&W 60 with banana grips, and Ruger SP101.. all .357s.
Any and all will do for CCW but... the pride of Deaf Smith's little collection is...
A S&W M66-1 and Ruger Security Six I converted to RB (round butt) both with Secret Service stocks. The Security Six is a bit heavier but can take alot of .357s while the S&W Combat Magnum has a slicker trigger.
Again, either one will do to ride the river with.
My S&W 65-5 'LadySmith' is right now at a gunsmith getting a red insert front sight but later (I hope before Christmas) to have it back in the fold.
"To you who call yourselves 'men of peace,' I say, you are not safe without men of action by your side" Thucydides
Deaf Smith
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World's shortest quest
My two favorite foods are probably carrots and eggs because I don't have to buy a special version of them, no matter what kind you buy they never have gluten and so they won't ever kill me or even make me sick.
Some things are hard or impossible to make gluten free - mostly pastries and bagels, and some things would probably be easy but no one does it - like Pop Tarts and Cheerios. And then some things are so easy apparently, that there are tons of them. Like Oreos.
There are at least a thousand (or three that I can think of) brands of gluten-free Oreos and all of them get incredible reviews. The incredible review is: "They taste just like Oreos."
Sometimes I buy them because I think there might be a brand I haven't had yet that will taste just like Oreos, sometimes I think maybe my life is actually a quest to find a really great wheat-free chocolate sandwich cookie and I start to think about the songs they will write about me and so I buy a lot of different types of these Oreos and recently I realized some bad news, I don't think it's the rice or quinoa or potato or whatever weird flour they're putting in that's the problem. I think I might not like Oreos.
The best thing about Oreos, even gluten-free ones is you can take them apart and build your own real Double-Stuf® Oreos, and the best thing about being an adult is you can just throw your Double-Stuf® Oreo in the trash, no one is going to make you eat it.
The best thing about being a rich adult is you can throw it in the garbage disposal.


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tag:blogger.com,1999:blog-47950641316372457382014-10-02T21:41:16.176-07:00GJ SampsonGalen & Julie Sampsonhttp://firstname.lastname@example.com:blogger.com,1999:blog-4795064131637245738.post-62466603015764420682010-09-01T18:46:00.000-07:002010-09-01T18:46:15.175-07:00One more golf night!A very sad sign that summer is fast coming to a close. Next Wednesday is our last golf night. Ronda and I golfed Kim Hintz and Sherry Durst and I had a 54.....not bad......but, I'd give anything to get a 40+ score this year. Only one more week left!

Tonight was a little cooler, but it felt good. Clouds were rolling in, but the rain is holding off.

Talked to Mom and Dad Sampson tonight and they said that Shirley Ney had an infection that was causing high fevers...they are now medicating and although it has set her back a week, she is improving. God bless Shirley.

gotta go...............................Galen & Julie Sampsonhttp://email@example.com:blogger.com,1999:blog-4795064131637245738.post-70161573752016013692010-08-31T18:30:00.000-07:002010-08-31T18:30:40.296-07:001st time blogging!This will be a new experience for me. I've always loved to write.....now I hope to do it quite often. Hopefully I can share my experiences, thoughts and quotes of the day!

We just came back from a weekend camping trip to Mill Creek State Park this past weekend. We rented the large cabin and Ted and Danielle brought their camper too! (they just loved having the camper all to themselves for two nights!) They had lots of camping equipment to share for the weekend and that was very nice. We missed Mike, Anne and Marlee as they were in Davenport for the weekend with family. Grandpa Heinzen suffered a blood clot on the brain during the week and was in hospice care. We will do this camping trip again next year! Great memories and a real close vacation spot!

We heard today that Grandpa Heinzen died. God bless him and may he enjoy his spot in heaven until we meet him again. We wish our deepest sympathy to his family and wish Grandma Joann comfort and peace as she learns to live without her life long partner. He lived a good life and I will always remember him as a kind, loving, happy man with quick humor. His family will miss him.

We went to the Taco House with Roger and Gerda tonight........fall is in the air and we need to get as many trips to Okoboji as we can. We had a great time catching up with good friends. They will meet Kallie and family in Wisconsin this weekend and then the weekend after camp with her family at Cutty's. We are two very busy couples and we cherish the times we can get together.

Better go............I think I'm going to like this!Galen & Julie Sampsonhttp://firstname.lastname@example.com