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By Michael Price Good luck finding a legislative issue more controversial than gun violence—at least in the United States. Compounding the controversy is a dearth of reliable data, thanks largely to a de facto ban on federally funded firearms research enacted in 1996. Yet a new study funded by Harvard Business School suggests that one policy—a mandatory waiting period between the sale of a gun and its delivery—could save hundreds of U.S. lives each year if implemented nationally. "Absolutely, this study demonstrates a robust association between waiting periods and gun deaths," says Margaret Formica, a public health researcher at the State University of New York Upstate Medical University in Syracuse who studies firearms deaths but wasn't involved in the new work. "It's an innovative way of looking at this issue." More than 33,000 Americans die each year in gun-related incidents, including accidents, homicides, and suicides, about as many as in vehicle accidents. But regulations that place limits on the sale and ownership of firearms vary widely from state to state, and it's unclear which measures might actually prevent gun violence. Some research from other countries has suggested that a "cooling off" period between the sale and delivery of a gun can tamp down suicidal impulses and anger-driven violence. So when Harvard University researchers were motivated to contribute to policy-relevant gun research in the wake of the 2012 Sandy Hook Elementary School shooting, such "waiting periods" were an easy jumping-off point. Not only was there past research, but data on waiting-period laws are relatively easy to track down. "Instead of saying, 'Isn't it a tragedy, children are dying, oh well, on to the next meeting,' we decided we wanted to do something," says Deepak Malhotra, a negotiation and conflict resolution researcher who co-authored the new study with economist Michael Luca. © 2017 American Association for the Advancement of Science
Keyword: Aggression
Link ID: 24205 - Posted: 10.17.2017
Jon Hamilton Brain imaging studies have a diversity problem. That's what researchers concluded after they re-analyzed data from a large study that used MRI to measure brain development in children from 3 to 18. Like most brain imaging studies of children, this one included a disproportionate number of kids who have highly educated parents with relatively high household incomes, the team reported Thursday in the journal Nature Communications. For example, parents of study participants were three times more likely than typical U.S. parents to hold an advanced degree. And participants' family incomes were much more likely to exceed $100,000 a year. So the researchers decided to see whether the results would be different if the sample represented the U.S. population, says Kaja LeWinn, an assistant professor at the University of California, San Francisco School of Medicine. "We were able to weight that data so it looked more like the U.S." in terms of race, income, education and other variables, she says. And when the researchers did that, the picture of "normal" brain development changed dramatically. For instance, when the sample reflected the U.S. population, children's brains reached several development milestones much earlier. © 2017 npr
Keyword: Brain imaging; Development of the Brain
Link ID: 24204 - Posted: 10.17.2017
By DOUGLAS QUENQUA In the days after his son was born, Rob Sandler found the thrill of becoming a new father replaced with dark feelings of dread and hopelessness. Those feelings, coupled with sleep deprivation and stress, culminated in a panic attack during his son's bris. As a group of old friends was saying goodbye after the ceremony, "I had this feeling that they were leaving and I was stuck in this situation that would never get any better," said Mr. Sandler, a marketing executive in Dallas. "I just felt trapped." What followed was months of sadness, anxiety and — perhaps most worrisome of all — a feeling of acute disappointment in his own ability to be a good parent. In recent years, a growing body of research, and the increasing visibility of dads like Mr. Sandler, has given rise to the idea that you don't have to give birth to develop postpartum depression, the so-called "baby blues." Studies suggest that the phenomenon may occur in from 7 percent to 10 percent of new fathers, compared to about 12 percent of new mothers, and that depressed dads were more likely to spank their children and less likely to read to them. Now, a University of Southern California study has found a link between depression and sagging testosterone levels in new dads, adding physiological weight to the argument that postpartum depression isn't just for women anymore. The study also found that while high testosterone levels in new dads helped protect against depression in fathers, it correlated with an increased risk of depression in new moms. "We know men get postpartum depression, and we know testosterone drops in new dads, but we don't know why," said Darby Saxbe, a professor of psychology at U.S.C. and an author of the new report. "It's often been suggested hormones underlie some of the postpartum depression in moms, but there's been so much less attention paid to fathers. We were trying to put together the pieces to solve this puzzle." © 2017 The New York Times Company
Keyword: Depression; Sexual Behavior
Link ID: 24203 - Posted: 10.17.2017
Katharina Kropshofer Life is not so different beneath the ocean waves. Bottlenose dolphins use simple tools, orcas call each other by name, and sperm whales talk in local dialects. Many cetaceans live in tight-knit groups and spend a good deal of time at play. That much scientists know. But in a new study, researchers compiled a list of the rich behaviours spotted in 90 different species of dolphins, whales and porpoises, and found that the bigger the species' brain, the more complex – indeed, the more "human-like" – their lives are likely to be. This suggests that the "cultural brain hypothesis" – the theory that suggests our intelligence developed as a way of coping with large and complex social groups – may apply to whales and dolphins, as well as humans. Writing in the journal, Nature Ecology and Evolution, the researchers claim that complex social and cultural characteristics, such as hunting together, developing regional dialects and learning from observation, are linked to the expansion of the animals' brains – a process known as encephalisation. The researchers gathered records of dolphins playing with humpback whales, helping fishermen with their catches, and even producing signature whistles for dolphins that are absent – suggesting the animals may even gossip. Another common behaviour was adult animals raising unrelated young. "There is the saying that 'it takes a village to raise a child' [and that] seems to be true for both whales and humans," said Michael Muthukrishna, an economic psychologist and co-author on the study at the London School of Economics. © 2017 Guardian News and Media Limited
Keyword: Evolution
Link ID: 24202 - Posted: 10.17.2017
By HEATHER MURPHY Can a fish be depressed? This question has been floating around my head ever since I spent a night in a hotel across from an excruciatingly sad-looking Siamese fighting fish. His name was Bruce Lee, according to a sign beneath his little bowl. There we were trying to enjoy a complimentary bloody mary on the last day of our honeymoon and there was Bruce Lee, totally still, his lower fin grazing the clear faux rocks on the bottom of his home. When he did finally move, just slightly, I got the sense that he would prefer to be dead. The pleasant woman at the front desk assured me that he was well taken care of. Was I simply anthropomorphizing Bruce Lee, incorrectly assuming his lethargy was a sign of mental distress? When I sought answers from scientists, I assumed that they would find the question preposterous. But they did not. Not at all. It turns out that not only can our gilled friends become depressed, but some scientists consider fish to be a promising animal model for developing anti-depressants. New research, I would learn, has been radically shifting the way that scientists think about fish cognition, building a case that pet and owner are not nearly as different as many assume. "The neurochemistry is so similar that it's scary," said Julian Pittman, a professor at the Department of Biological and Environmental Sciences at Troy University in Alabama, where he is working to develop new medications to treat depression, with the help of tiny zebrafish. We tend to think of them as simple organisms, "but there is a lot we don't give fish credit for." Dr. Pittman likes working with fish, in part, because they are so obvious about their depression. He can reliably test the effectiveness of antidepressants with something called the "novel tank test." A zebrafish gets dropped in a new tank. If after five minutes it is hanging out in the lower half, it's depressed. If it's swimming up top — its usual inclination when exploring a new environment — then it's not. In Dr. Pittman's lab, researchers induce depression in a fish by keeping it drunk on ethanol for two weeks, then cutting off the supply, forcing it into withdrawal. This here is a depressed fish. Both clips, which represent a small segment of the five minute tank test, were extracted at comparable speeds. Troy University © 2017 The New York Times Company
Keyword: Depression; Evolution
Link ID: 24201 - Posted: 10.17.2017
Jules Montague Steve Thomas and I are talking about brain implants. Bonnie Tyler's Holding Out For a Hero is playing in the background and for a moment I almost forget that a disease has robbed Steve of his speech. The conversation breaks briefly; now I see his wheelchair, his ventilator, his hospital bed. Steve, a software engineer, was diagnosed with ALS (amyotrophic lateral sclerosis, a type of motor neurone disease) aged 50. He knew it was progressive and incurable; that he would soon become unable to move and, in his case, speak. He is using eye-gaze technology to tell me this (and later to turn off the sound of Bonnie Tyler); cameras pick up light reflection from his eye as he scans a screen. Movements of his pupils are translated into movements of a cursor through infrared technology and the cursor chooses letters or symbols. A speech-generating device transforms these written words into spoken ones – and, in turn, sentences and stories form. Eye-gaze devices allow some people with limited speech or hand movements to communicate, use environmental controls, compose music, and paint. That includes patients with ALS – up to 80% have communication difficulties, cerebral palsy, strokes, multiple sclerosis and spinal cord injuries. It's a far cry from Elle editor-in-chief Jean-Dominique Bauby, locked-in by a stroke in 1995, painstakingly blinking through letters on an alphabet board. His memoir, written at one word every two minutes, later became a film, The Diving Bell and the Butterfly. Although some still use low-tech options (not everyone can meet the physical or cognitive requirements for eye-gaze systems; occasionally, locked-in patients can blink but cannot move their eyes), speech-to-text and text-to-speech functionality on smartphones and tablets has revolutionised communication. © 2017 Guardian News and Media Limited
Keyword: Robotics
Link ID: 24200 - Posted: 10.16.2017
By Rhianna Schmunk, CBC News Researchers from the University of British Columbia are retracting their scientific paper linking aluminum in vaccines to autism in mice, because one of the co-authors claims figures published in the study were deliberately altered before publication — an issue he says he realized after allegations of data manipulation surfaced online. The professor also told CBC News there's no way to know "why" or "how" the figures were allegedly contorted, as he claims original data cited in the study is inaccessible, which would be a contravention of the university's policy around scientific research. The paper looked at the effects of aluminum components in vaccines on immune response in a mouse's brain. It was published in the Journal of Inorganic Biochemistry on Sept. 5. Co-authored by Dr. Chris Shaw and Lucija Tomljenovic, it reported aluminum-triggered responses "consistent with those in autism." Shaw said he and Tomljenovic drew their conclusions from data that was "compiled" and "analyzed" for the paper, rather than raw data. However, subsequent scrutiny has raised questions about the validity of the data, with one doctor calling the paper "anti-vaccine pseudoscience." By the middle of September, commenters on PubPeer — a database where users can examine and comment on published scientific papers — pointed out that figures in the study appeared to have been altered, and in one case lifted directly from a 2014 study also authored by Shaw and Tomljenovic. ©2017 CBC/Radio-Canada.
Keyword: Autism
Link ID: 24199 - Posted: 10.16.2017
By John Horgan To help my students appreciate how science reflects cultural prejudices, I often cite examples from psychiatry. The Diagnostic and Statistical Manual of Mental Disorders, or DSM, which the American Psychiatric Association compiles as a guide to diagnosis and treatment of illness, listed homosexuality as a "sociopathic personality disturbance" in the DSM-I, published in 1952, and as a "sexual deviation" in the DSM-II, published in 1968 (see Further Reading). Homosexuality has been treated with lobotomies, chemical castration, electrical shocks and nausea-inducing drugs as well as psychotherapy. I then tell my students about a bizarre gay-conversion experiment carried out in 1970 by a leading brain-implant researcher, Dr. Robert G. Heath of Tulane University in New Orleans. I mentioned Heath in my recent profile of Jose Delgado, a pioneer in the use of brain implants to manipulate patients' minds and behavior. Heath was arguably even more ambitious than Delgado in his experiments, and he was not a fringe figure. He had degrees in psychiatry and neurology from Columbia and the University of Pennsylvania. n 1949 he founded Tulane's department of psychiatry and neurology. He oversaw the department until 1980 but continued working into the 1990s. In his 1996 book Exploring the Mind-Brain Relationship, he reviews his career and speculates that someday "biological methods" might make it possible "for man to live in harmony with his fellow man." © 2017 Scientific American,
Keyword: Sexual Behavior
Link ID: 24198 - Posted: 10.16.2017
Carl Safina Last week footage of five young elephants being captured in Zimbabwe to sell to zoos travelled round the world. Parks officials used helicopters to find the elephant families, shot sedatives into the young ones, then hazed away family members who came to the aid of the drugged young ones as they fell. The film, shared exclusively with the Guardian, showed the young captives being trussed up and dragged on to trucks. In the final moments of footage, two men repeatedly kick a small dazed elephant in the head. Removing young elephants from their parents and sending them into captivity is largely justified on the basis that they do not feel and suffer as we do. For decades we have been admonished against anthropomorphism – imbuing animals with human-type emotions such as sadness or love. But, actually, humans have these emotions because other animals do as well. Brain science, evolutionary biology, and behavioural science now show that elephants, humans, and many other animals share a near-identical nervous system and likely experience near-identical basic emotions. Human and elephant brains are bathed in the same chemicals that create mood and motivation in us. We are all mammals, and under the skin we are kin. Scientists have watched rats' brains as they dream, and dogs' brains showing love. In fact, sperm whales' family structure is nearly identical to that of elephants. Animals living in stable social groups – apes and monkeys, wolves and wild dogs, hyenas and cats, various birds, some dolphins and others, know who they are and whom they are with. © 2017 Guardian News and Media Limited
Keyword: Emotions; Evolution
Link ID: 24197 - Posted: 10.16.2017
by Sari Harrar, AARP Bulletin, At 99 years old Brenda Milner continues to explore the mind and its relationship to people's behavior. You're a preeminent neuroscientist, and a professor at Canada's prestigious McGill University. At age 99, what motivates you to keep up your research at the Montreal Neurological Institute and Hospital? I am very curious. Human quirks attract my interest. If you're a theoretical person, you can sit and dream up beautiful theories, but my approach is, What would happen if or, Why is this person doing [that] and then, How can I measure it? I wouldn't still be working if I didn't find it exciting. AARP Membership: Join or Renew for Just $16 a Year Are you curious in real life, too? Yes. I'm a good "noticer" of behavior as much as the kind of furniture people have! In the 1950s, you made a revolutionary discovery that memories are formed in a brain area called the hippocampus, which is now getting lots of attention for its role in memory loss and dementia. Has brain research gotten easier? Nowadays, everyone has functional magnetic resonance imaging. Anybody with access to a medical school can get a good look at the patients' brain while they're alive and young, but it wasn't like that [then]. Psychologists were studying patients who were much older and beginning to show memory impairment. Then they had to wait for their patients to die.
Keyword: Learning & Memory
Link ID: 24196 - Posted: 10.16.2017
By James Gallagher Health and science reporter, BBC News website A hallucinogen found in magic mushrooms can "reset" the brains of people with untreatable depression, raising hopes of a future treatment, scans suggest. The small study gave 19 patients a single dose of the psychedelic ingredient psilocybin. Half of patients ceased to be depressed and experienced changes in their brain activity that lasted about five weeks. However, the team at Imperial College London says people should not self-medicate. There has been a series of small studies suggesting psilocybin could have a role in depression by acting as a "lubricant for the mind" that allows people to escape a cycle of depressive symptoms. But the precise impact it might be having on brain activity was not known. Image copyright Getty Images The team at Imperial performed fMRI brain scans before treatment with psilocybin and then the day after (when the patients were "sober" again). The study, published in the journal Scientific Reports, showed psilocybin affected two key areas of the brain. The amygdala - which is heavily involved in how we process emotions such as fear and anxiety - became less active. The greater the reduction, the greater the improvement in reported symptoms. The default-mode network - a collaboration of different brain regions - became more stable after taking psilocybin. Dr Robin Carhart-Harris, head of psychedelic research at Imperial, said the depressed brain was being "clammed up" and the psychedelic experience "reset" it. He told the BBC News website: "Patients were very ready to use this analogy. Without any priming they would say, 'I've been reset, reborn, rebooted', and one patient said his brain had been defragged and cleaned up." © 2017 BBC
Keyword: Depression; Drug Abuse
Link ID: 24195 - Posted: 10.16.2017
By Elizabeth Pennisi One man's trash is another man's treasure, even at the level of the cell. That's where—according to new research—a waste product of the retina fuels part of the eye that powers the rods and cones that help us sense light. Without this waste, that part of the eye "steals" glucose from the retina, leading to the death of retinal cells and likely vision loss. The finding could help explain why eyesight degenerates with age—and in diseases such as macular degeneration and diabetes. "It's almost a revolutionary concept" that there is such a tight coupling between the two parts of the eye, says Stephen Tsang, a retina specialist at Columbia University who was not involved in the work. Rods and cones are very active, and they need a lot of energy to do their jobs. Exactly how they get this energy has long been a mystery. In previous studies, researchers showed that a layer of cells beneath the retina, the retinal pigment epithelium (RPE), ferries glucose from the blood to the retina. But it was unclear why the RPE didn't keep the glucose for itself. After a decade of study, biochemist James Hurley at the University of Washington in Seattle and his colleagues have now shown that the retina's rods and cones burn the glucose, convert leftovers into a fuel called lactate, and then feed that back to the RPE. "There is a growing consensus that no cell exists on its own in complex tissues like the retina," says Martin Friedlander, an ophthalmologist at The Scripps Research Institute in San Diego, California, who was not involved with the new work. © 2017 American Association for the Advancement of Science.
Keyword: Vision
Link ID: 24194 - Posted: 10.14.2017
By Jessica Hamzelou A rare sighting of a chimpanzee giving birth in the wild came to a grisly conclusion. Within seconds of the birth, the baby was snatched away and eaten by a male of the same group. The observation explains why female chimpanzees tend to go into hiding for weeks or months when they have their babies. Little is known about how chimpanzees give birth in the wild because only five births have ever been observed, says Hitonaru Nishie of Kyoto University in Japan. Nishie and his colleagues have been studying chimpanzees in Tanzania's Mahale mountains for the last few years. One of the reasons so few have been witnessed is that the soon-to-be mothers often leave the group when the baby is due, and don't return until the infant is weeks or months old. This absence has been described as a chimpanzee's "maternity leave". So Nishie and his colleague Michio Nakamura were surprised when, at around 11 am one December day, a female member of the chimpanzee group they were observing began to give birth in front of the 20 other members. As soon as the baby was out – and before the mother had even had a chance to touch it – the baby was snatched away by a male member of the group, who then disappeared into the bush. The researchers found him around 1½ hours later, sitting up a tree and eating the infant from the lower half of its body. He ate the entire body within an hour. © Copyright New Scientist Ltd.
Keyword: Aggression
Link ID: 24193 - Posted: 10.14.2017
Heidi Ledford The US government is considering whether to approve a gene therapy to prevent the degradation of cells in the retina (shown here in an image from a scanning electron microscope). Advisers to the US Food and Drug Administration (FDA) have paved the way for the agency's first approval of a gene therapy to treat a disease caused by a genetic mutation. On 12 October, a panel of external experts unanimously voted that the benefits of the therapy, which treats a form of hereditary blindness, outweigh its risks. The FDA is not required to follow the guidance of its advisers, but it often does. A final decision on the treatment, called voretigene neparvovec (Luxturna), is expected by 12 January. An approval in the lucrative US drug market would be a validation that gene-therapy researchers have awaited for decades. "It's the first of its kind," says geneticist Mark Kay of Stanford University in California, of the treatment. "Things are beginning to look more promising for gene therapy." Luxturna is made by Spark Therapeutics of Philadelphia, Pennsylvania, and is designed to treat individuals who have two mutated copies of a gene called RPE65. The mutations impair the eye's ability to respond to light, and ultimately lead to the destruction of photoreceptors in the retina. The treatment consists of a virus loaded with a normal copy of the RPE65 gene. The virus is injected into the eye, where the gene is expressed and supplies a normal copy of the RPE65 protein. © 2017 Macmillan Publishers Limited
Keyword: Vision; Genes & Behavior
Link ID: 24192 - Posted: 10.14.2017
By Virginia Morell Dog owners often wonder what—if anything—is going on when their pooches are sleeping. It turns out they may be learning, according to a new study. Researchers in Hungary trained 15 pet dogs to sit and lie down using English phrases instead of the Hungarian they already knew. Afterward, the scientists attached small electrodes to the dogs' heads to record their brain activity while they slept. Electroencephalograms (EEGs) showed that during 3-hour naps, the dogs' brains experienced brief, repeated moments of "slow-wave" brain activity, lasting 0.5 to 5 seconds. These bursts—called sleep spindles because they look like a train of fast, rhythmic waves on EEG recordings—occur during non-REM sleep and are known to support memory, learning, general intelligence, and healthy aging in humans and rats. But this is the first time they've been studied in detail in dogs. Like those of humans and rats, the dogs' sleep spindles occur in short cycles in the 9-hertz to 16-hertz range; in humans and rats, these cycles are associated with memory consolidation. The scientists also discovered that the number of spindle sessions per minute correlated with how well the dogs learned their new, foreign vocabulary, the researchers report this week in Scientific Reports. And—just like in humans—females had more spindle sessions per minute than males and performed better during testing. About 30% of the females learned the new words, compared to about 10% of the males. That suggests, the researchers say, that dogs can serve as models to better understand the function of our own sleep spindles. © 2017 American Association for the Advancement of Science
Keyword: Sleep; Learning & Memory
Link ID: 24191 - Posted: 10.14.2017
by Robby Berman Our problem with opioids has been in the news a lot lately, and for good reason: It's arguably the worst drug problem the U.S. has ever faced. The leading cause of death for people under 50? Opioids. According to the CDC, between 1999 and 2015, over 183,000 Americans have died of overdoses from prescription opioids alone. The agency estimates that more than 1,000 people receive emergency treatment for prescription overdoses every day. While those numbers are leveling off a bit now — perhaps as doctors become more careful about prescribing them — the number of deaths from non-prescription opioids is rising fast. Overdoses are easy to count, but nearly as disturbing, if less visible, is how many people are dependent on these drugs. The CDC estimates that in 2014 that number was two million Americans. The top three prescription opioids causing overdoses, says the CDC, are methadone, oxycodone (including OxyContin®), and hydrocodone (including Vicodin®). The two leading non-prescription killers on the rise are heroin and fentanyl, the drug that killed musician Prince. Experts believe that prescription opioids serve as gateways for illegal ones, so getting prescription use under control may be the key first step. Meanwhile, watch this. If you've ever thought that those who become dependent on opioids are weak or have defective personalities — and that these drugs might be safe for others, even you — this video from Lily Fang about how they work in the human brain reveals why these pain-killers are so incredibly dangerous. The video was created for a HarvardX class. © Copyright 2007-2017 & BIG THINK,
Keyword: Drug Abuse
Link ID: 24190 - Posted: 10.13.2017
Haroon Siddique Magic mushrooms may effectively "reset" the activity of key brain circuits known to play a role in depression, the latest study to highlight the therapeutic benefits of psychadelics suggests. Psychadelics have shown promising results in the treatment of depression and addictions in a number of clinical trials over the last decade. Imperial College London researchers used psilocybin – the psychoactive compound that occurs naturally in magic mushrooms – to treat a small number of patients with depression, monitoring their brain function, before and after. Images of patients' brains revealed changes in brain activity that were associated with marked and lasting reductions in depressive symptoms and participants in the trial reported benefits lasting up to five weeks after treatment. Dr Robin Carhart-Harris, head of psychedelic research at Imperial, who led the study, said: "We have shown for the first time clear changes in brain activity in depressed people treated with psilocybin after failing to respond to conventional treatments. "Several of our patients described feeling 'reset' after the treatment and often used computer analogies. For example, one said he felt like his brain had been 'defragged' like a computer hard drive, and another said he felt 'rebooted'. "Psilocybin may be giving these individuals the temporary 'kick start' they need to break out of their depressive states and these imaging results do tentatively support a 'reset' analogy. Similar brain effects to these have been seen with electroconvulsive therapy." © 2017 Guardian News and Media Limited
Keyword: Depression; Drug Abuse
Link ID: 24189 - Posted: 10.13.2017
Jo Marchant Male scientists are more likely to share their published work than are women — but only with other men, a study of hundreds of researchers has found. Humans are generally considered to be a highly cooperative species, says Jorg Massen, a cognitive biologist at the University of Vienna. But most of the evidence for that assumption comes from artificial situations such as computerized cooperation tasks. "I wanted to test human prosociality in an everyday situation," he says. So he chose one of the most competitive situations he could think of: his own field of research psychology. To investigate cooperation among psychologists, Massen turned his fellow researchers into guinea pigs. He and his colleagues e-mailed nearly 300 researchers and asked them to share either a PDF of one of their latest papers, or some raw data (pretending that they wanted to include it in a meta-analysis). The results were published in Scientific Reports on 10 October1. In general, the scientists contacted were highly cooperative, with almost 80% willing to share a PDF and almost 60% willing to send raw data. "I was surprised," says Massen. "Humans are prosocial even in this competitive field." Even more unexpected, however, was a strong gender difference in how the scientists responded to the request for help. Massen and his colleagues had wondered whether men might respond more favourably to women, or vice versa. In fact, men were more likely to share, but only with other men. A male–male request was 15% more likely to be granted than any other gender combination. © 2017 Macmillan Publishers Limited,
Keyword: Sexual Behavior; Aggression
Link ID: 24188 - Posted: 10.13.2017
By Helen Thomson The most detailed study yet of orgasm brain activity has discovered why climaxing makes women feel less pain and shown that 'switching off' isn't necessary. It's not easy to study the brain during orgasm. "A brain scanner like fMRI is the least sexy place in the world," says Nan Wise at Rutgers University in Newark, New Jersey. "It's noisy, claustrophobic and cold." There is also the problem of keeping your head still – movement of little more than the width of a pound coin can render data useless. Despite these hurdles, Wise and her colleagues recruited 10 heterosexual women to lay in a fMRI scanner and stimulate themselves to orgasm. They then repeated the experiment but had their partners stimulate them. Wise's custom-fitted head stabiliser allowed the team to follow brain activity in 20 second intervals to see what happens just before, during, and after an orgasm. Pain relief Back in 1985, Wise's colleagues Beverly Whipple and Barry Komisaruk, both at Rutgers, discovered that, during self-stimulation and orgasm, women are less likely to notice painful squeezing of a finger, and can tolerate more of this pain. They found that women's ability to withstand pain increased by 75 per cent during stimulation, while the level of squeezing at which women noticed the pain more than doubled. Now Wise's team has explained why. At the point of orgasm, the dorsal raphe nucleus area of the brain becomes more active. This region plays a role in controlling the release of the brain chemical serotonin, which can act as an analgesic, dampening the sensation of pain. © Copyright New Scientist Ltd.
Keyword: Sexual Behavior; Attention
Link ID: 24187 - Posted: 10.13.2017
Laura Sanders The brain's mapmakers don't get a break, even for sleep. Grid cells, specialized nerve cells that help keep people and other animals oriented, stay on the clock 24/7, two preliminary studies on rats suggest. Results from the studies, both posted October 5 at bioRxiv.org, highlight the stability of the brain's 'inner GPS' system. Nestled in a part of the brain called the medial entorhinal cortex, grid cells fire off regularly spaced signals as a rat moves through the world, marking a rat's various locations. Individual grid cells work together to create a mental map of the environment. But scientists didn't know what happens to this map when an animal no longer needs it, such as during sleep. Grid cells, it turns out, maintain their mapmaking relationships even in sleeping rats, report two teams of researchers, one from the University of Texas at Austin and one from the Norwegian University of Science and Technology in Trondheim. (The Norway group includes the researchers who won a Nobel Prize in 2014 for discovering grid cells (SN Online: 10/6/14).) By eavesdropping on pairs of grid cells, researchers found that the cells maintain similar relationships to each other during sleep as they do during active exploration. For instance, two grid cells that fired off signals nearly in tandem while the rat was awake kept that same pattern during sleep, a sign that the map is intact. The results provide insights into how grid cells work together to create durable mental maps. © Society for Science & the Public 2000 - 2017.
Keyword: Learning & Memory
Link ID: 24186 - Posted: 10.13.2017


text:
OTRS Certification Program
Think OTRS. Be an Expert! Take the advantage of our certification program and be an OTRS native (speaker). The OTRS Academy offers the possibility to become a certified OTRS Admin.
Strengthen your knowledge, be an expert, think OTRS!
Certification Dates: OTRS certified Administrator
Start of exam: 5:30 pm
Duration of exam: 90 minutes
Dates in Europe
|Oct 12
|Straubing / DE
|Nov 09
|Oberursel (near Frankfurt a.M.) / DE
|Dec 07
|Straubing / DE
Dates in North America
|Sep 29
|Houston, Texas / USA
Dates in Latin America
Dates in Asia
|Oct 21
|Shenzhen / China
|Nov 11
|Shanghai / China
|Dec 09
|Beijing / China
- Our certificate supports your perception as an expert
- It increases your reputation as a specialist
- The certificate is a benefit for your references
- It assures a standardized level of knowledge within the team
The certification costs $325 / 250€.
The exam lasts 90 minutes.
You have the possibility to take the test either in German or English.
Our exam consists both of multiple choice questions. With the multiple choice questions single and multiple answers are possible. The questions will be offered through an online platform. Depending on the difficulty level you receive between one and three points per question.
The following categories are part of the exam:
- OTRS Terminology & Usage
- OTRS Installation
- Authorization Concepts
- Administration Tasks
- Implementing Business Logics (= PostmasterFilters, Generic Agents, event-based Notifications, ACLs)
- Filesystem / Shell
- Configuration (= Config.pm und SysConfig)
- OTRS Process Management
Ideally, you attend the OTRS Administrator Training. We also recommend at least 6 months of experience as an OTRS Administrator.
Deadline for registration is one week prior to examination date.
You will be informed about your result via email. If your examination has been successfully completed you will receive your certificate a few days later by post.
Yes, you can retake the examination at any time and without any waiting period.
The certificate is always issued on the current OTRS release and will therefore not lose its validity.

subset: commoncrawl


text:
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Being able to capture and keep it there recording the moment which is why I purchased more and more popular option and gif maker tool. Very useful camera app and the plastic spools, near the DVR "Input" ports.
More, us Searches Google Camera Google Camera offers motion sensing, and the signal for a while, but I would highly recommended wireless home cameras over wired security system can be roughly identified during the day of fiddling before I bought this system has turned back wifi on, the cameras work on fixing this issue.
So, stay tuned - there is something less bitter, less inglorious, perhaps even in the camera.


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Colorado Elite Recreational Tumbling and Stunt Classes Winter Session October 23rd – February 4th Monday: Tiny Tumblers - 4:00-5:00pm Tuesday: Just a Tuck/Handspring - 5:00pm-5:45pm Thursday: Beginning Tumbling - 5:00pm-6:00pm Intermediate Tumbling Class - 6:00pm-7:00pm Advanced/Elite Tumbling Class - 7:00pm-8:00pm Saturday: Beginning Cheer 9:00am-10:00am Intermediate Tumbling Class 10:00am-11:00am Beginning/Intro Tumbling 11:00am-NOONTiny Tumblers – For athletes 18 months to 3 years old. Participants
Know someone interested in cheerleading? Looking for an alternative to competitive cheerleading? Have a younger sibling interested in cheerleading? The Colorado Elite Pre-Team Cheerleading Program is perfect for you or your athlete.What is the Elite Pre Team? The Elite Pre Team is a part of our All Star Program. On this
Colorado Elite Bring A Friend Week! July 24-27th!
Colorado Elite Summer Open House Friday July 21 – 6 to 8pm!
Come see us Friday July 21, 6-8pm! Check out the facility and meet the coaches! Looking for tumbling and cheer classes? Come in and receive information on Rec scheduling and prices. Interested in cheering at the competitive level? We have teams for all ages and skill levels! come join us and receive info on All
United Elite Fall Recreational Tumbling and Cheer Classes
United Elite Fall Tumbling and Cheer Session August 1st – October 20th Monday: Preschool Tumbling 3:30-4:15 pm Beginning Tumbling 5:30-6:30 pm Tuesday: Beginning Tumbling 5:30-6:30pm Intro Tumbling 5:30-6:30pm Intermediate Tumbling 6:30-7:30pm Advanced Tumbling 6:30-7:30pm Elite Tumbling 6:30-7:45pm Wednesday: Beginning Tumbling 4:30-5:30pm Thursday: Beginning Tumbling 5:30-6:30pm Intermediate Tumbling 6:30-7:30pm Advanced Tumbling 6:30-7:30pm NEW! Saturday: Preschool Tumbling 9:00-9:45am Intro Tumbling 9:00-10:00am Preschool Open Play 10:00-11:00am Beginning Tumbling 10:00-11:00am Beginning Cheer 11:00-NOON Elite Tumbling 11:00am-12:15 pm Prices
United Elite Special Events
Join us for tons of fun over the summer at your kids favorite place to be! 9:00 am – 3:00 pm daily Cost: $75.00 per day $350.00 for the week Register Today by E-mailing [email protected]
United Elite Birthday Parties
United Elite Birthday PartiesWhy a United Elite Birthday Party? • No hassle with set up and clean up! • Fun-filled space with enthusiastic coaches • Invitations and goody bags are provided for an easy experience • A MILLION picture opportunities Types of Parties: Basic: Party Attendant, 1 Hour in Gym, 30 Minutes in Party Area, Invitations, Set
We Are Elite
United Elite Preschool Open Play
United Elite
Colorado Elite
The 2017 Colorado Elite Tryout Packet is out! COE Tryout Packet 2017-2018 We'd love to have you! A whole new STORM is coming to Colorado Springs!Filling positions for the following teams for the 2017-2018 season: Level 1 (All Ages) *Teams to be named later* Tiny Prep (3-6) *FLURRIES* Youth L2 (6-11) *FROST* Junior L2 ( 8-14)
It was a great first competition for our Elite In State Teams this weekend at the Rockstar Championship!
This past Sunday, December 11th, was the first competition of the season for our four Elite In State Teams! It was a great outing for our teams from NorCo Elite, North Metro Elite and United Elite at the Rockstar Championships! NorCo Elite's Youth 1, Passion came out on the floor with
Elite High School Spotlight: Poudre Varsity
Elite High School Spotlight: Sand Creek High School
Elite High School SpotlightSand Creek High School The girls of Sand Creek Varsity are some of the hardest working out there. They always come in with a determination to be even slightly better than they were yesterday. They have come so far this season, gaining new skills along the way. They
Elite High School Spotlight: Mitchell High School
Elite High School Spotlight: Chaparral Varsity
Elite High School Spotlight: Skyline High School
Elite High School Spotlight: Ralston Valley All Girl
Elite High School Spotlight RALSTON VALLEY ALL GIRL Ralston Valley All Girl is a unique, energetic group of young women. A majority of the ladies on this squad have never cheered before this season. But their drive and determination is unmatched by any other squad. Though they share the same talkative gene


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Elementary Band and Orchestra Pre-registration is Open
Hello 5th grade parents and students! Pre-Registration for 5th grade band and orchestra is available online now. Click the big blue link below to get started. Just looking for information about the program? Click here to download a copy of the Elementary Band and Orchestra Parent Guide.
Be sure to visit the "Elementary Band Corner" by clicking on the tab in the side menu. This is where Mr. Ronning will post assignments and notices for 5th graders. Orchestra students will find information about string classes on Mr. Banet's web page.
Save the date: Wednesday, Sept. 20 is Music Night, is our annual event where parents can register their children for classes, meet the teachers, and rent instruments. In the meantime, we will be visiting the elementary schools on September 20 and 21 to talk to kids and provide a guided, hands-on with the instruments. Classes begin on September 26, and we're really looking forward to working with our newest young musicians!
Jazz Band Auditions September 19-21.
Interested in joining the jazz band? Download the audition packet to get started. Audition dates and times for each instrument, rehearsal schedule, and general info are included. If you're interested but aren't sure if you should audition after looking through the packet, feel free to come talk to me after school to get more info.
Beginning Band
The BeginBand.com website contains useful information about beginning band. It also has sound clips for each instrument. The following lists show selected content from the site. Click on the links below for direct access to the article or FAQ's.
Three articles to read with a parent:
- Selecting the Right Band or Orchestra Instrument
- A General Overview of the Instruments
- Tips on Buying Quality Band and Orchestra Instruments
Frequently Asked Questions about Band and Orchestra
- Which instruments are allowed in band or orchestra?
- Is it possible to play the guitar or piano in band or orchestra class?
- Which instrument should I choose?
- Should we buy a new or used instrument?
- What's the difference between a fiddle and a violin?
- What's the difference between a Violin and Viola?
- The saxophone is too big or too expensive. Is there an alternative to a saxophone for beginners?
- Should we start with the Alto or Tenor Saxophone?
- Is it possible to play the oboe or the bassoon as a beginner?
- What's the difference between a trumpet and a cornet?
- Which percussion instrument should we start with?
- Which instrument is the easiest to learn?
- Do girls or boys do better on certain instruments?
- How often should a beginner practice?
- Who is qualified to teach private lessons to a beginner?
Concert Dress for Mason Bands
Beginning & Intermediate Band
Khaki (tan) pants and a navy blue polo with dark shoes and socks.
Advanced Band
Black dress pants and a white dress shirt (or white blouse for girls) with black socks and shoes. A black tie is optional for boys.
Concert & Jazz Band
Black dress pants, black dress shirts or blouses, with black socks and dress shoes. (Jazz band members who are in Advanced Band need only wear these outfits.)
Elementary Band
There is no particular uniform for our elementary students. Students are encouraged to wear clean, "dressy" clothes for concerts.


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Our very own Shiguma was kind enough to hash out a preview of Koudelka for you all to read and learn from(this happened only after we beat him over the head several times with a Thigh Master we found in Chrono's basement). Shiguma took time to write about the awesome graphics found in the Japanese version of the game and what we can expect here in April. Be sure to read all about Koudelka right here.
Also, don't forget to sign up for the Alundra 2 contest here at RPGFan. There are only a few days left so go sign up! Link is on the left navigational bar of the page.
That's it for this round folks. I was going to give you all a shinny new preview of Square's Final Fantasy IX today. Then I thought, "Why not hype it up a bit?" :P Check back later this weekend for one of the first previews of Square's Final Fantasy IX to be found on the net!
Heh, like my new staff pic? Chronologist is the image masta! :P
Date Updated:March 25th, 2000
Time Updated:2:00 PM
Related Links:
Previews Section
Alundra 2 Contest
Final Fantasy XIV Patch 4.1
Sunday, October 15 • 10am PDT/1pm EDT
Final Fantasy XII: The Zodiac Age
Mondays • 6pm PDT/9pm EDT
Vandal Hearts
Tuesdays • 12pm PDT/3pm EDT
Tues-Wed-Thu and Saturdays • 7pm PDT/10pm EDT


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06 04 2016Ping An Raises RMB Fund to Invest in U.S. Real Estate
Paul Hastings is represented Ping An, a leading personal financial services group in China, in raising a Chinese RMB fund and forming two joint ventures with Pacific Eagle (US) Real Estate Fund, L.P. for the development of two U.S. residential real estate projects in San Francisco and Malibu, California.
Pacific Eagle (US) Real Estate Fund, L.P., Ping An's joint venture partner, is a private equity fund co-sponsored by Great Eagle Holdings Limited, a leading Hong Kong property company with a long-term track-record in the U.S. real estate market, and a wholly-owned subsidiary of China Orient Asset Management Corporation, one of the four assets management companies approved by the PRC State Council. The deal marks the first time Ping An has raised an RMB fund from high net worth investors for investment in U.S. residential development, and signals that Chinese private equity funds are following Chinese developers and insurers and are playing a more active role in both the global real estate market in general, and the US development market in particular. The Paul Hastings team was led by real estate partners David Blumenfeld (Picture) and Paul Guan, with support from real estate associate Eugenie Hui. Involved fees earner: David Blumenfeld - Paul Hastings; Eugenie Hui - Paul Hastings; Paul Guan - Paul Hastings;
Hong Kong has become a city of bright expansion, culture, and futuristic innovation. Fr
Fintech, it's described as the disruption in financial services pushed by consume
On October 14th, 2016, the world's leading corporate stars aligned for a momentou
More than 19 Excellences in the global economy at the VI Annual Edition of IAIR AWARDS&
It took place on 19 November 2015 at Palace Downtown in Dubai the 19th edition of the I


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Cheryl Papasian MRBS
- Contact:
- Website: http://www.cherylpapasian.com
Cheryl Papasian is a sculptor based in London working with bronze, plaster and plastic. Interested in materials and the artificial, her installations and sculptures explore the closing gap between high and low culture.
Cheryl Papasian is concerned with surfaces in sculpture and inconsistences in the values of materials. Her installations combine synthetic and traditional materials that seek to question the materiality of consumer products and art objects. Ideas of artificiality, luxury and the closing gap between high and low culture are crucial to Cheryl's practice. She is also interested in finishes that imitate gold or bronze but are actually plastic, wood or plaster.
Her recent sculptures are influenced by the Japanese Zen gardens she saw in Kyoto. Her use of gold surfaces hints at luxury, money and hoarding possessions. As well as large-scale installations, Cheryl creates smaller works, combining found objects and handcrafted pieces concentrating on metallic or shimmering surfaces, faux luxury materials and the use of synthetics. Cheryl received an MA Fine Arts from Chelsea College of Art in 2013. She has worked and exhibited in London, Tokyo, New York, Glasgow, and Paris.
- Categories: Abstract, Installation/Land/Site-specific, Conceptual
- Materials: Brick/Concrete/Plaster, Bronze, Found Objects
- Location: London


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being friends with lilac has taught me some things about grid computing. today i met with lucent alcatel, which has a product called datagrid.
So this is why datagrid is so cool: This is a very low-latency (1-2 milisecond) middleware server that can pass data between a collection of back-end databases and front-end applications. Unlike Tivoli or other traditional IT middleware, it has much less latency. Currently runs on Solaris or Linux. Eventually will move to IT environments, e.g. Intel. Started out as a technology for HLR applications (Home Location Register, a way to do authenticate a wireless phone as the phone roams from location to location) and then became more robust to use more generically. For example they use it to do single-sign on for customer care reps at Sprint. He also mentioned they run in a vmware environment, but not sure I can fully appreciate the beauty of this.
How neat is that? And for the technologists out there, help me correct my logic gaps. I think i got the nouns right, if not the verbs.
Wednesday, September 10, 2008
the GRID post
Posted by PD at 7:54 PM
1 comment:
- Lilac - Like The Flower said...
fascinating. it's griddy.. but my big question would be - does it pass data at that latency across a LAN or WAN? since really, to be griddy, you need multi-location crossplatform support. But still, super cool. Bonus points if they have an algorithm that minimizes latency based on pattern recognition and traffic patterns.
Who knows, I might go telco yet! we seem to have an impact on each other. GO GRID!
- September 10, 2008 at 9:59 PM
Subscribe to: Post Comments (Atom)


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ESP CheckMatetm has been selected by AOPA's Air Safety Foundation, to be included, as official course materials fortheir renown Pinch-Hittertm course.
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Those who have been spreading the word about the Early Support app have been telling anyone who will listen about the way that it puts the Early Support approach and principles into practice in one handy tool; this is social networking with knobs on, and with a hefty padlock provided.
It is designed to be a way for families to save all the important information about their child, in one place, and to enable them to share the information that they want with professionals and family.
However, frustratingly, the release of the final version has been put back a couple of times. Zoe Davies has been testing out the beta version. Here she tells us whether it's going to be worth the wait.
The Early Support App is very easy to use and with the frequent developments information is becoming easier and easier to input. The App allows a parent carer or young person to 'own' it and so they are very much in control of the information held and can present it in a way suitable to their needs. It also allows the family to 'invite' professionals and family members to access information they would like to be shared. Messages can be sent to these people, saving time on telephone calls, where frequently the person is unavailable and messages have to be left.
The information allows the focus to be about the 'whole' young person rather than just their difficulties, which is often the emphasis of meetings. Photos and video clips can also be added, which makes the App very personal and allows a professional to have more insight into a young person than just being told does would.
The App has a calendar on it which is brilliant for appointment tracking and a timeline, which is very useful for recording key events. This again is great for focussing attention on achievements rather than just difficulties, which traditional paper records do not include.
The story about the young person does not have to be repeated every time there is an appointment or meeting and information is available without having to carry folders of reports everywhere. It also, very importantly, means that vital information can be shared between services so that nothing is missed. All too often reports sent via post do not make it to the right person in time for a meeting, meaning valuable appointment time is wasted revisiting information that should have been available.
I will definitely be recommending the App. It will make life so much easier; allowing information to be shared instantly and to be on hand whenever it is needed. It will save time preventing retelling the same story and allow meetings to be far more efficient as old ground will not have to covered again. It also brings attention away from difficulties and back to celebrating what the young person is actually capable of.
The Early Support App runs on Apple iPads and is also available through a web browser on a computer or mobile device. Training sessions will be on offer as soon as the App is released. Get in touch with us here at In Principle if you'd like to know more about that.


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Herbal dog remedies
Everything you need to know about "herbal dog remedies" for healing your dog's allergies and improving its health
All about herbal dog remedies
Herbs have long been used to treat and prevent sickness in people, and apart from smelling good and adding an extra "something" to cooking, certain herbs can help improve your dog's quality of life, too.
Herbs contain antioxidants, enzymes, amino acids, chlorophyll, minerals, trace elements, vitamins, carbohydrates, essential fatty acids, proteins and sugars all in a natural form, just as Nature intended.
In fact, the use of herbal dog remedies is becoming more and more popular as many pet owners seek natural and effective "at-home" ways to treat and heal their pets.
It is important to bear in mind though, that whilst most herbs are perfectly safe for dogs, some can be toxic especially if given in combination with conventional medications/drugs.
So please don't go it alone, seek guidance from an holistic veterinarian who will evaluate your dog's allergy symptoms/health conditions (e.g. hair loss, intestinal worms, gas and many more) and prescribe an herbal remedy/s in the correct amounts to balance your dog's body.
Dogs seem to instinctively know that eating certain herbs and or plants has a positive impact on their health - eating grass to bring on vomiting to be rid of something toxic is an excellent example of this.
Once your vet has set out an "herbal dog treatment plan", why not consider growing your own herbs. You don't need a lot of space, in fact a window box will do the trick perfectly.
This way you can be sure the herbs are organically grown and you may even end up saving a few dollars on visits to the health store. And lets face it, saving money is always a good thing.
If you are wondering about what herbs will work best to treat specific conditions and allergies for your dog, think of it as if you were treating yourself. For instance, in the same way that chamomile will help to soothe your nerves and send you off to sleep, it will work in exactly the same way for hyperactive pets who need to slow down.
To include herbs in your pet's diet, try picking fresh herbs from your window box or garden; either chop them up finely or use a mortar and pestle and then mix them into your dog's food. Alternatively you can always make teas with herbs and either mix the tea with their food or give it them to your dog orally with an eye dropped. You can also buy tinctures of herbs from reputable health stores.
Certain herbal teas can also be very beneficial for pouring over your pet as a wash to sooth itchy skin and kill parasites.
Herbal dog suggestions to stop your dog itching and/or to treat other ailments Nature's way
Aloe Vera
Herbal Dog - Aloe Vera
This spiky leafed herb is pretty amazing stuff. Its benefits and medicinal value has been appreciated since ancient times, helping to heal wounds and even stomach ulcers in humans. Fortunately the herb is equally as good for dogs.
It is extremely important however for pet owners to be aware that aloe vera can be "toxic to pets" if eaten in its pure, undiluted, and concentrated plant form. As such it can cause the following conditions ranging from mild to severe symptoms:
If you feel your dog has eaten aloe vera in plant form and it is showing one or more of the above symptoms, to the point where you are concerned. Please call the "Pet Poison Helpline". This is a 24-hour animal poison control service available throughout the U.S., Canada, and the Caribbean for pet owners, and veterinary professionals who require assistance with treating a potentially poisoned pet.
Herbal Dog - Calendula (flowers) or Pot Marigolds
The bright and yellow flowers of this easy-growing herb have magical powers when it comes to treating stings, bites, cuts, scrapes and wounds, both on humans and dogs. Whilst the herb has many different applications (including anti-fungal, anti-inflammatory, and the cooking pot), it is mainly used to sooth and heal wounds.
Taken internally, the herb can:
If you have a dog itching from allergies its a good idea to make a tea from the flower petals. You can use the tea as an entire body wash to sooth its itchiness and also to kill off any bacteria that may be lurking around on its skin or in its coat.
A word of caution - although Calendula is considered to be one of the safest herbs for humans and dogs, it is potentially toxic to cats. Please don't share this herb with your family cat.
Herbal Dog - California Poppy, Chamomile and Valerian
Herbal Dog - Dandelion
Dandelion is a universal wild plant, rich in vitamins and minerals, and found growing everywhere including in domestic lawns and gardens. It is an absolutely amazing herb to help heal your dog and is distinguished for its multi-purpose ability to:
Herbal Dog - Eyebright
Eyebright for dogs is an amazing herb to help with all conditions pertaining to the eyes, from irritations and inflammation to acute infections.
The herb is excellent for:
For readers interested in more information about eyebright, please click this eyebright link to a detailed PDF.
Herbal Dog - Garlic (bulbs)
You may have heard that garlic is bad for dogs.
Well, garlic has been used for many years by holistic veterinarians. The confusion about whether garlic is good or bad seems to have arisen from confusion with its close cousin, the onion. Both garlic and onion contain thiosulphate, the substance responsible for causing 'Heinx Factor' anemia in dogs.
When garlic is ingested in reasonable amounts there are no harmful affects, but there are plenty of beneficial qualities:
Courtesy of Ottawa Valley Dog Whisperer Blogspot
Garlic Caution
Garlic should not be fed to dogs:
Herbal Dog - Ginger
Can I give my dog ginger? - Yes, in small amounts
Ginger has been highly prized for centuries as a medicinal herb for treating and prevent medical problems in humans and animals - particularly in Asia.
In dogs ginger can help with:
Other reasons to give dogs ginger
If your dog is experiencing muscle spasms in its stomach or back, a few drops of ginger tincture will sooth and relax stressed muscles and relieve its pain.
Apart from its delicious taste, humans have used ginger for years to help in the absorption of food, and of course it does the same for dogs.
Herbal Dog - Turmeric
Turmeric, is a spice derived from the root of the Curcuma longa plant, which is a perennial plant of the ginger family. Tumeric is also known as Indian Saffron.
Curcumin is the most active curcuminoid found in turmeric, and provides turmeric with its:
Herbal Dog - Milk Thistle
This article looks at the effects that milk thistle has on our dogs, for instance:
Is milk thistle safe for dogs?
Yes, milk thistle is perfectly safe for dogs as long as it is given in correct dosages. Please see "What is an appropriate dosage?" below.
What are the health benefits of milk thistle for dogs?
Milk thistle has been used for many years as a liver stimulant for both humans and pets, and one of the most important compounds in the herb is "silymarin".
Silymarin supports and protects the liver and as such, milk thistle is very effective in treating dogs with:
What is an appropriate dosage?
For other liver problems, 75 to 100 mg per 10 pounds of body weight per day is sufficient to see results.
If milk thistle causes a stomach upset, gas, or mild diarrhea in your dog, simply reduce the dosage.
Milk thistle for dogs - precautions
Despite the fact that milk thistle is hailed as "the" herb for the liver, it should NOT be given to healthy dogs as a daily supplement. Some studies show that long-term use of very high dosages of milk thistle will eventually suppress liver function.
Milk thistle should therefore be used only as a medicinal herb for the treatment of liver disorders and other health problems as mentioned above.
Additionally, silymarin is not recommended for use in pregnant women and therefore it is probably a good idea not to use milk thistle in pregnant dogs until more information becomes available.
Courtesy of Natural Dog Health Remedies
For readers wishing to have additional detailed information on the benefits of milk thistle for dogs, please click here to read an excellent PDF written by Dr. Hofre DVM
Herbal Dog - Rosemary (leaves, stems and flowers)
Rosemary is a woody perennial herb which has been used for centuries as both a culinary herb and a medicinal plant.
How to make a rosemary dog wash
Not only is a rosemary was a natural flea repellant, it will leave your dog's coat silky, glossy, and smelling beautiful.
How to use a rosemary dog wash
Using a rosemary wash is easy peasy, especially if you are already about to give your pet a bath.
Rosemary caution
Even though it is rare, some dogs like people can be allergic to rosemary, before rushing full blast, try a tiny amount in its food first, or do a test patch on one of its paws with the wash before drenching your dog all over. first.
Please do not give rosemary to pregnant dogs
And finally, if you would like to combine the enormous benefits of flower essences with your herbal holistic pet care for your treasured pet please click Flower Essences Holistic Care For Dogs and explore Only Natural's huge choice.
As a family we regularly use "Rescue Remedy Pet" for our pets, kids and grown ups!!
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I have used Rescue Remedy (shown below) for the past 24 years (actually, lets be specific - I have used it for my darling doggie Poppie and her predecessors) and found it absolutely marvelous! If you need to calm your pet down at any time, give it a go, you won't regret it (Poppie usually uses it before her bath time). Each bottle lasts her for ages!
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This is a dark green "Rubies and Ribbons" minus the ribbons. I followed the pattern except for the eyelets, and added one inch to each sleeve.
After soaking the finished knit, I would have liked to hang in up like a "Hvirvelstroem", but the yarn stretched too much in the vertical direction. So I let it dry flat for one day, and then hung it up sideways in order to provoke some horizontal stretch.
79691 projects
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ALIENUS meaning in Law Dictionary
Lat. Another's; owned by another; the house of another. Alicnus homo, another's guy, or slave. Inst. 4, 3, pr. Alicna res, another's residential property. Bract, fol. 136.
Sentence Examples with the word ALIENUS
During the civil war he fought on the side of Otho against Vitellius, and obtained a considerable success against Aulus Caecina Alienus (one of the Vitellian generals) near Cremona, but did not follow it up. When Caecina had been joined by Fabius Valens, Paulinus advised his colleagues not to risk a decisive battle, but his advice was disregarded, and Otho (q.v.) was utterly defeated at Bedriacum.


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Hello, my name is Brook and I would like to apologise that this product is not fully translated. I am working hard to remedy this. Would you like to help?
Wireless camera Smanos IP6 will be your remote eye and ear on your home or office while you are away....
The NC210 IP Camera is a 720p HD (720p) Cloud Wireless...
IP camera OPEXIA OP-CS01 can monitor space on all sides for low light conditions and is comfortably accessible via smartphones. Just install the Google Android or Apple iOS application EZVIEW and access it at will. Handles Upload up to 4 devices . Installing from a smartphone via QR code is a simple 3 steps.
Extending its scope to ensure motorized rotation angle of 270 ° and tilt up to 90 ° . For two-way voice communication has 2-way audio, speaker and therefore the built-in microphone. Record video runs at 30 frames per second, so the record will be completely smooth. For night visibility has built-in IR LED light and IR filter, so you will see in complete darkness up to 10 meters .
Additional information:
Sensor: CMOS (0.3 megapixel) with IR filter
Resolution 640x480 (VGA), 320 x 240 (QVGA)
Speed: up to 30 frames per second
The AF 13 IR LED
Night visibility: up to 10 meters
Motorized rotation: 270 °, tilt: 90 ° (16 preset positions)
Supports up to 4 simultaneous devices
EZVIEW Application for Android and IOS
QR function: the installation of the smartphone in just 3 steps
Memory Slot (Micro SD) card up to 32GB
Stream Codec: MJPEG
WiFi (IEEE 802.11b/g/n) (WEP, WPA, and WPA2-PSK encryption)
Email, HTTP or FTP notifications triggered by motion detection
2-way audio
Easy login via web browser
Specifications can be changed without notice. Images are for illustrative purposes only. Retail Price (MSRP) means the manufacturer's/supplier's suggested retail price.
Link to Manufacturer's Website: Enter link to the external review


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Managed Print & Digital Solutions
Contract ID: RM3785
Start Date: 28/12/2016
End Date: 27/12/2018
Through this framework, which is open to all public sector organisations and charities, you can acces
- Fully managed end to end print and digital solutions (lot 1)
- Tailored managed print solutions, where the service offering is tailored to suit individual customer requirements as specified at further competition stage (lot 2)
The range of products and services available includes:
- Print and paper products
E.g. envelopes, labels, wallets, folders.
- Pre-production services
E.g. proofs, print ready artwork, artwork for online templates, basic design and artwork, page layout, photograph retouching, typesetting, proof reading, translation services etc.
- Operational print
- Security print including personnel
- Large format and wide print
- Direct mail and transactional print
- Media duplication
- Full range of finishing services
- Scanning and microfiche
- Digital asset management
- Database management
- Stock management
- Storage, fulfilment and distribution
- Digital solutions
Benefits of using the framework
Strategic supplier partnerships
· Suppliers will use their expertise and guidance to drive savings.
· Support with moving towards digital solutions, where required.
Savings through a transparent price model
· Associated cost savings through standardisation, rationalisation and aggregation of demand.
· Competitive paper pricing and rate cards with maximum rates.
A complete print and digital solution
· Sourcing of all raw materials including paper and envelopes.
· Wide range of associated services available as part of a core print requirement providing a total print solution.
Managed print solution
· The supplier will manage the operational delivery of print requirements including supply chain sourcing and management. This applies to both lots.
As lot 1 is a single supplier you can place a direct award.
Lot 2 has six suppliers and a further competition is required to access this lot
The lot 2 ratecard contains pricing for a small number of printed items (business cards, leaflets, posters, flyers) which some customers may wish to purchase on an ad hoc basis - direct award may be possible for these items. For all other requirements a further competition is required to enable a comparison of quality and pricing in order to select a supplier.
We recommend you read the guidance documents available via the documents tab to assist you with accessing the framework agreement
You will need to develop a specification of your requirements. The Tips for completing your Statement of Requirements/Specification document provides a comprehensive structure to help you.
The frequently asked questions outlines in more detail the scope of both lots and their associated service levels, information about further competition, and call-off contract terms.
If you are a customer currently using the Print Vendor Partner (PVP) contract, it also addresses transition and implementation, including how to transition and what to prepare.
The framework guidance notes provide further guidance on how to access the framework and how to carry out a further competition
The agreement was developed to provide the UK public sector with a single route to market for print requirements. It offers a standardised price model to allow for greater transparency of costs. It replaces:
• Print Vendor Partner (RM921) which expires on 30 June 2017
• Wider Public Sector Print (RM1687) which expired on 30 April 2016
The agreement has been developed following extensive market and stakeholder review, taking into consideration stakeholder expertise and market knowledge.
Lot details
|Lot Number
|Lot Name
|Lot Category
|Number of Suppliers
|Contract Expiry
|All suppliers
|7 - click here to view suppliers
|Fully Managed End to End Print and Digital Solutions
|1 - click here to view suppliers
|Tailored Managed Print Solutions
|6 - click here to view suppliers
- Framework Specification 1.7 MB
- Tips for creating your print specification 435.05 KB
- Customer Guidance Notes RM3785 60.09 KB
- OJEU Notice 94.91 KB
- Command & House Papers Specification 857.56 KB
- RM3785 Framework Overview 540.73 KB
- RM3785 Framework Agreement 299.55 KB
- FAQs V1.0 146.64 KB
- Template Order Form and Call Off Contract v1.4 1.37 MB
Framework Manager Contact Details
Print Category Team
0345 410 2222


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For Children
Published: December 15, 1989
Shows, Nature, Museums ''ALADDIN,'' a play performed by the Royal Buckingham Theater Company, 8 P.M. on Fridays and Saturdays, and 3 P.M. on Saturdays and Sundays, through Jan. 15, at the Nat Horne Theater, 440 West 42d Street. Tickets: children, under 12, $10; others, $15. Information: 279-4200. ''THE DANGEROUS CHRISTMAS OF RED RIDING HOOD,'' with music by Jule Styne, lyrics by Bob Merrill and book by Robert Emmett, with previews at 7:30 tonight, 1 and 3:30 P.M. tomorrow and 1 P.M. on Sunday; regular performance at 3:30 P.M. on Sunday. Tada Theater, 120 West 28th Street. Admission: children, $5; adults, $7. Information: 627-1732. ''ALFRED THE DRAGON AND THE WIZARD,'' a play about a shy dragon who lives in Central Park and a sly wizard, written by Miranda McDermott, with child actors of the New Media Repertory Company, 3 P.M. on Saturdays, at 512 East 80th Street. Tickets: children, $4.50; adults, $5. Reservations required: 734-5195. ''THE CHRISTMAS SPIRIT,'' a play about the importance of giving simple gifts in the holiday season, presented by a new group, Any Theater Company, 2:30 P.M. tomorrow, at the Heckscher Oval, Children's Library, Lincoln Center. Free. Visitors may donate toys or clothing, particularly mittens, hats or scarfs, to be given to the Partnership for the Homeless. Informaton: 870-1630.


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Serving Oklahoma since 1976
Robert has been in business since 1976 and has over 40 years of experience as an electrician and contractor. He specializes in all things electric, be it residential or commercial.
Robert started Baxter Electric in 1976. Bored with retirement, Robert started Robert Baxter Electric in 2011, , specializing in residential and commercial electric services.
Robert has been on the Board of Directors of the Edmond Chamber of Commerce and Central Oklahoma Home Builders Club, was the President of the American Business Clubs, and was a professional drummer in his teenage years. He even ran for mayor of Edmond in 1996!
Robert Baxter Electric: Personal, Professional, Precise.
Copyright 2017 © Robert Baxter electric, LMR Marketing Solutions
Contact Us 24/7:
Cell: (405) 664-8330
Office: (405) 340-5670
Mailing Address:
2421 NW 160th St.
Edmond, OK 73013
East Location:
408 Timberdale Terrace
Edmond, OK 73034


text:
Yale University. Music Library
From Library of Congress Name Authority File
Yale University. Music Library
Instance Of
Scheme Membership(s)
Collection Membership(s)
- Yale University Music Library
- John Herrick Jackson Music Library
- Irving S. Gilmore Music Library
- Gilmore Music Library
Additional Information
Exact Matching Concepts from Other Schemes
- found: Perlis, V. Charles Ives papers, 1983: t.p. (Yale University Music Library)
- found: The Neumeister collection of chorale preludes ... c1986: introd., p. 1 (John Herrick Jackson Music Library, Yale University)
- found: Irving S. Gilmore Music Library WWW home page, Nov. 2, 2001 Collections page (the music library moved to a new facility in 1998, named for Irving S. Gilmore (Yale '23))
- found: Yale University Library Libraries & Collections site, Oct. 24, 2013 (Gilmore Music Library)
Change Notes
- 1985-06-07: new
- 2013-10-29: revised
Alternate Formats


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Anna Maria College famous athletes
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Get info about Anna Maria College famous athletes, and registering for elective seminars and discussion sections. Not all recruiting is done like NCAA Division I teams. College coaches want to hear from serious recruits throughout their high school career. Don't be shy to send videos of your best games to college coaching staff or scouts. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Anna Maria College Athletics information. Please use the form above to request admissions info for Anna Maria College.
Stay in great shape, even through the off-season. Being physically fit includes knowing about nutrition, staying healthy, and not overworking your body before big games. Practice the basics, over and over, especially targeting skills related to your position. Become a super-specialist, and you'll always find your place on an athletic team. Keep your eyes on the ball, and sacrifice your body if you must, but don't drop the ball.
Watch the ball all the way into your hands, and get a good initial grip. Your sixth sense needs to be developed to stay aware of other players at the same time. Follow the advice that college coaches give you, and it will make a big difference in how you play. That's because most college coaching staff were star players at some point in their careers. Bowling Green State University rowing club may encourage student-athletes to apply via early decision. Students who are considering applying via early decision should be aware of the rules and obligations that this commitment entails. Beyond consideration for Anna Maria College famous athletes, you may think about Lake Area Tech add drop deadline for complementary electives to your primary course of study.
Sports Director
YMCA of Metropolitan Dallas
Must have knowledge of rules for youth and adult sports including, but not limited to, basketball, football, baseball, volleyball..
1 day ago Trainer/Fitness Professional - Springfield, MA
Quick-Jab Properties LLC
Or a 4-year degree in a health related field such as Exercise Science or Kinesiology with the intent to receive a certification within 90 days of hire date.
1 day ago 5/6th Grade Baseball Head Coach
Christian Academy School System
Managerial and coaching experience. Supervise the coaching staff of the sport program on all levels to ensure athletes and coaches are growing spiritually.
6 hours ago Sports Camp Coach
ESF Camps
As a Coach at Dream Camp at Trinity College you are assigned to a group of 10 campers and will work collaboratively with another coach and their team totaling..
1 day ago Pharmacy Technician Specialist (16459)
Personal/ Associate Development. Trains, coordinates and directs pharmacy staff in all aspects of third party plan administration.
2 days ago


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This is the second in a series of posts about the NJ-SCBWI Annual Conference. Visit all this week for insights from this incredible children's book writing event.
…continued from previous post…
After seven years, Kate decided she wanted to live a life in which she was always making art. She had fear as a writer, especially in revision, but instead of the terror paralyzing her any longer, it motivated her.
Kate introduced writing's first contradiction: "you go on a long journey but stay in the same place." The writing can take you anywhere, but you are still a lonely writer sitting at a keyboard.
Kate explained that a career in writing means you have to "chart a course through the contradictions." She revealed five pieces of contradictory writing truths:
- Be absolutely rigid; Be loosey-goosey.
- Write only for others; Write only for yourself.
- Hide yourself; Reveal yourself.
- Compromise; Never compromise.
- Listen to what other people say; Don't listen.
Kate had a good friend Oscar during that not-writing-but-wanting-to-be-a-writer seven-year stretch. One day they discussed belief in miracles and Kate told Oscar that she wanted to be a writer.
"Baby, that don't take a miracle. That's all on you," Oscar said.
She had never realized that the whole of the task was on her. You have to do what you promise yourself. After years of brooding, she came to know that it was "easier to do the work than to NOT do the work." Just in case we didn't get it, she repeated this several times.
Yes, art and fear always go together. The constant feeling of uncertainty creates a tolerance for uncertainty. In other words, embrace the terror. It's a prerequisite for success.
As I sat in the balcony, I had my own epiphany. Writing picture books is my comfort zone. My middle grade novel has been sitting untouched for more time than I'm willing to reveal. And it's languishing out of pure fear: fear of ruining what I already adore, fear of not knowing what comes next, fear of writing more than 600 words IN A ROW. Why have I not embraced the fear before? Kate DiCamillo says she never works with an outline; "an outline kills it." She writes to know what happens next. And that's how I write, too. I enjoy discovering the story as I write. But I thought writing a novel like that was WRONG. Now I understand that nothing is wrong, it's just the way I like to work.
So when Kate says "be absolutely rigid", she means to commit yourself to the work. But when she contradicts this advice with "be loosey-goosey" she means the stories want love and joy and play. Go ahead and write without an outline, don't plot where you're going and you'll journey somewhere totally unexpected. She equates this first contradiction with standing at a door and knocking. You must stand there, but how you knock is up to you. Shave and a haircut? A rock riff? Gentle tapping? How will you knock?