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Which is better to cook with, oil or butter?
Please help keep the community civil. The Doctors moderates this forum and all comments must follow TheDoctorsTV.com Community Guidelines and New Terms of Use . The Doctors reserves the right to use the comments you submit in whole or in part, and to use the commenter's name and location, in any medium. Note that DISQUS operates this forum and you must log-in or register with DISQUS to participate.

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University of Maryland
From PhD Prep Track
The University of Maryland is located in College Park, Maryland, which is part of the Washington D.C. greater metropolitan area. Here are some links to general information about Maryland's doctoral programs and to its accounting Ph.D. programs.
- University of Maryland Accounting Research Ranking
- University of Maryland Ph.D. Accounting Research Ranking
LDS Church Information
There is a temple in Washington D.C.
External Links
- Information on Accounting Ph.D. Programs - Results from a survey conducted by AAA on the University of Maryland's Accounting Ph.D program.
|Main Page ► University Information ► University of Maryland


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Zimbabwe elections a militarised form of authoritarianism - analyst
- 13/08/2017 02:43:00
- 1
- 0
"The Zimbabwean electoral problem fits well in what is conceptualized as machinations of a Competitive Electoral Authoritarianism or put more vividly, a militarized form of electoral authoritarianism founded on a serious synthesis of ZANU-PF and the security forces," he said.
"This despotic concoction has been generously dispersed across key state institutions that are looked upon by citizens for credible and acceptable elections such as the judiciary, legislature, executive and ultimately ZEC so that the decisive authority of the people's vote is neutralized. Forthcoming publication (Empirical Audit of the Zimbabwean Electoral Problem: Inside ZANU-PF Gerrymandering)."
CLICK HERE TO READ MORE FROM: Africa
About Article Author
Chuka is an experienced certified web developer with an extensive background in computer science and 18+ years in web design &development. His previous experience ranges from redesigning existing website to solving complex technical problems with object-oriented programming. Very experienced with Microsoft SQL Server, PHP and advanced JavaScript. He loves to travel and watch movies.View More Articles


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Amwaj Oyoun Resort & Spa
Nabq Bay, Sharm el Sheikh
A stunning resort providing guests with everything needed for a fabulous holiday. Whether its relaxing by the pool or on the beach or taking part in one of the many activities offered including a diving and snorkelling, theAA Amwaj Hotel provides it all.
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The facilities provided for guests at the complex includes a 24 hour reception, concierge service, secretarial services, 24 hour room service, wireless internet, in house doctor and clinic, laundry and valet service. There is also a variety of shops, limousine and car rental service.
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Some facilities may incur a local charge.
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Special Information
Please note; rates displayed are not available for Egyptian Nationals and are for UK Passport Holders Only.
If you are travelling to Sharm el Sheikh for less than 15 days, you will receive a free entry permission stamp on arrival. If you intend to stay longer, you can purchase a visa on arrival for approx $25 USD.
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Mrs Cockram, Mar 2012
See what else our customers are saying about us
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Lobster bisque by jasper white
Recipes / Lobster bisque by jasper white (1000+)
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title of this group is inspired by a GREAT cookbook by James Villas with the same name
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week in the city. A week that was highlighted by consuming 6 whole fish and 3 crabs washed
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Read helpful reviews of the recipe for Chunky Lobster Stew, submitted by Epicurious.com members ... People keep giving me Jasper White cookbooks, PLEASE STOP! ...


text:
The Oyster
Contributed by John Edmerson on Sep 13, 2001 (message contributor)
There once was an oyster whose story I tell,
Who found that sand had got under his shell;
Just one little grain, but it gave him much pain,
For oysters have feelings although they're so plain.
Now, did he berate the working of Fate
Which had led him to such a deplorable state?
Did he curse out the Government, call for an election?
No; as he lay on the shelf, he said to himself,
"If I cannot remove it, I'll try to improve it."
So the years rolled by as the years always do,
And he came to his ultimate destiny—stew.
And this small grain of sand which had bothered him so,
Was a beautiful pearl, all richly aglow.
Now this tale has a moral—for isn't it grand
What an oyster can do with a morsel of sand;
What couldn't we do if we'd only begin
With all of the things that get under our skin.
Author Unknown
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Contributed by Ed Vasicek on Oct 18, 2000
Practical direction for real life found in Deuteronomy. In our day, we need guidance and to have the responsibilities of kindness defined.
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From: firstname.lastname@example.com (Timothy W. Lynch) Newsgroups: rec.arts.startrek.reviews,rec.arts.startrek.current,rec.arts.sf.tv Subject: [ENT] Lynch's Spoiler Review: "Cogenitor" Followup-To: rec.arts.startrek.current,rec.arts.sf.tv Date: Mon, 7 Jul 2003 22:38:54 +0000 (UTC) Organization: California Institute of Technology, Pasadena Lines: 301 Approved: firstname.lastname@example.com Message-ID:
Reply-To: email@example.com NNTP-Posting-Host: alumnus.caltech.edu X-Trace: naig.caltech.edu 1057617534 16489 126.96.36.199 (7 Jul 2003 22:38:54 GMT) X-Complaints-To: email@example.com NNTP-Posting-Date: Mon, 7 Jul 2003 22:38:54 +0000 (UTC) Keywords: ENT, Trip, interference X-Newsreader: NN version 6.5.0 #10 (NOV)
WARNING: Spoilers lurk ahead for ENT's "Cogenitor".
In brief: A few plot conveniences, but fairly meaty stuff.
"Cogenitor" Enterprise Season 2, Episode 22 Written by Rick Berman & Brannon Braga Directed by LeVar Burton
Brief summary: A first contact leads Trip to get overly involved with the life and rights of a new species' "cogenitor."
Marketing is evil.
"Cogenitor" is a case in point. It's an interesting episode dealing with the rights of an individual vs. society, questioning how well you can understand a situation without knowing the culture, and addressing some decidedly unsettling issues in the era before the Prime Directive's come into being.
So what does the preview show?
"These guys need three to mate! Slaverslaverslaver. Phlox has pictures!"
Christ on a pogo stick. If anyone thinks that approach is going to *attract* viewers, I'd be more than happy to sell them some beachfront property in Nebraska.
Having been predisposed to expect the worst based on the preview, I actually found myself pleasantly surprised by "Cogenitor." The leering, adolescent approach I've seen this show exhibit when it comes to almost anything sexual was absent ... or at least toned way down. Instead, we mostly got a character piece questioning when and in what fashion interference is okay.
Things begin pleasantly enough. While exploring a hypergiant star, our heroes run into a species that calls itself the Vissians. They're technologically well ahead of humans, but willing to share, very open about life, and extremely friendly: all they want in return for helping with some sensor modifications is to be invited over for a visit. Trip observes puckishly that "it'll be nice to have a first contact where nobody's thinkin' about charging weapons."
The meeting (in the mess hall, of course) has lots of small talk, but the real story starts when Trip wanders over to say hello to the Vissians' chief engineer. He does in fact meet the engineer, along with his wife, and a third person who's all but silent. The Vissians, it turns out, are tri-gender, needing a third sex in order to conceive a child. This "cogenitor" is the only one on the Vissian ship, and is on Enterprise as something of a special occasion.
Trip is initially taken aback by this, wondering aloud to Phlox how such a thing could possibly work. Phlox isn't especially surprised, though, and is more amused than anything else by Trip's reaction, urging him to "keep an open mind."
As Archer befriends the Vissian captain and heads off with him to explore the outer edge of the hypergiant in their "strato-pod," Trip continues his work with the engineer, but also continues to ask about the cogenitor, wondering what it does most of the time. When he discovers that it isn't sent to school and doesn't do much beyond eat and sleep, he begins to wonder about the cogenitor's rights. Despite Phlox's urgings that he not get involved, he surreptitiously takes brain scans of the cogenitor, along with the engineer and his wife. When he discovers that the cogenitor is just as mentally capable as the other two genders, he can't stay on the sidelines any more. He surreptitiously meets with the cogenitor and begins teaching it to read.
If there's any real negative to this story, it's just a plausibility question or two about Vissian society. We see evidence (both in this plotline and in others) that Vissians are extremely capable intellectually, retaining almost all of what they read in no time at all -- which makes one wonder why the Vissians would be so quick to keep their cogenitors ... well, "barefoot and pregnant" isn't the right term, really, but it's an apt enough analogy. It's strongly implied that they're not the ones who actually carry the child to term, so there's no "for the child's sake" argument preventing them from being independent. Why, then?
I'm also a bit unclear about exactly why Trip takes this big an interest, but as Archer points out later, Trip is one who tends to be impulsive, so it's not a big deal.
Regardless, once Trip starts his crusade there's really no going back. There's a lovely scene where he more or less browbeats the cogenitor into accepting that it might have abilities and rights no one had ever told her about -- actress Becky Wahlstrom does a marvelous job capturing the cogenitor's uncertainty, showing it as both curious and deeply unsettled. The single line "why are you doing this? It's not right for me to read" speaks volumes.
Trip convinces it, however, and in less than a day the cogenitor is reading quite well. Trip tells it there's a lot more than geography textbooks to read, and that more than reading, there's also lots of things out there to *experience*. He mentions the mountain range it just read about, for instance: "readin' about 'em is one thing ... climbin' is another." The cogenitor agrees, and as Trip leaves it says that it wants to be named Trip, just like him.
Shortly thereafter (probably the next day, though it's not very clear), Trip continues his quest and shows off the Enterprise to the cogenitor. It gets to see the transporter, main engineering, and Trip's quarters, where he shows it a movie. It's eager to see and experience more, but Trip gets it back to the Vissian ship before they're discovered.
Here's the other bit that seemed awfully artificial to me. I know that the Vissians are friendly, but the idea that someone can come and go between ships with absolutely no one noticing strains credibility a lot. Even more odd is the idea that Trip can usher the cogenitor into engineering with a quiet "the coast is clear," implying that the place is empty. Engineering? Empty? I'm thinking not. Again, it's a fairly minor point, as the emotional core of the story is pretty much rock- solid, but it did tend to snap me out of the story from time to time.
After this visit, of course, everything hits the fan. The Vissians discover (albeit very late) that Trip has been lying about his whereabouts -- it's not clear whether they know what he's really been up to, but T'Pol is informed that Trip's no longer welcome. After Trip gets a bit of a dressing-down (I almost wrote "tongue-lashing," but given many of the show's tendencies I think it'd be taken the wrong way), he returns to work ... only to see the cogenitor enter shortly thereafter and tell him that the Vissians are angry with him. "They don't want me to climb mountains," it says, and insists that only he can help. "I want to stay here, please." The Vissians, on the other hand, want it back immediately, and there's quite a problem waiting for Archer as soon as he returns.
The occasional plausibility concerns aside, this becomes a fairly juicy moral dilemma. Do you help the cogenitor, knowing nothing about the broader society in which it functions and possibly damaging relations with the Vissians for a long time to come? Or do you stay on friendly terms with the Vissians, returning the cogenitor to its "rightful" home, knowing that in the process you've likely raised hopes only to dash them and leave it far worse off than it originally was?
Plausible arguments can be made on either side, and much to its credit
"Cogenitor" tries to keep the process somewhat even-handed. The Vissians are shown to be kind, warm people -- and the engineer rather pointedly makes it clear to Archer that judgments in absence of a cultural context can be prone to some heavy-duty mistakes. Cogenitors are also rare enough that granting this one asylum may keep the engineer and his wife from having a child for a long time to come, depending on how long this mission is. Archer is clearly torn.
Now, for what it's worth, I don't think I would have decided the issue the same way. My own viewpoint tends to be that anyone or anything sentient enough to want freedom (or asylum, which is sort of the equivalent in this case) with a full understanding of what it entails should be granted it. (I remember back in TNG's "The Measure of a Man," the question was raised about whether you'd allow the Enterprise computer to refuse a refit. As far as I'm concerned, the answer was "yes, if it understood the concept sufficiently to reject it." I still think that.) I might have tried to split the difference, saying that the cogenitor should stay with its "assigned" couple long enough to let them conceive a child, *then* come back to Enterprise -- I've no idea whether that could have worked logistically, but I'd probably have considered it. The more I think about it, the more I think I disagree with Archer's choice -- but I do understand it. The issue isn't his fault -- he just got caught in the middle, and the show does an admirable job showing that.
Archer, however, lets Trip have it with both barrels, especially when Trip protests that "I did exactly what you'd do, Cap'n." Archer vehemently denies that, saying that the issue is so complicated that "don't tell me you know what I would've done when *I* don't even know what I would've done!" Archer's reaction is the first time in a while that Scott Bakula's performance has really impressed me, and it's some of the most honest emotion we've seen from Archer in the series' history.
I read some of it a bit differently, though, as I think Trip had a serious point there. Archer goes on and on about how he always tries to balance his own belief in what's right with the need to respect other cultures -- but so far as I can tell, if he's trying that he's not doing a great job. He dictates to the Vulcans. He tells Phlox just an episode earlier to override his own medical ethics. He never takes T'Pol's advice, even when she's right. Archer says a lot about respecting other cultures, but his actions tend not to back that up. Personally, then, I think Trip called it beautifully -- and while that doesn't make Archer's anger and upset any less honest, it motivates it differently. I think Trip struck home, and subconsciously Archer knows it. That's why he's so upset -- most of us are never so prone to jump on flaws as when they're ones we see mirrored in ourselves.
It doesn't help matters when Archer's choice winds up leading to tragic consequences. Shortly after the Vissians and the Enterprise part company, Archer gets a message from the Vissian captain: the cogenitor has committed suicide. Archer tells Trip this, who's utterly shocked. He says, almost to himself, "It's my fault. I'm responsible," and Archer wheels on him with a "you're damned right you are!" It's clear from Archer's further dialogue, though, that he's at least partially blaming himself. He tells Trip that "it's time you learned to weigh the possible repercussions of your actions," and blames himself for not getting that through to Trip very successfully. (Again, I suspect here that he's realizing he's been a truly terrible role model in that regard, but the scene works well either way.) Trip tries to tell Archer that he's not responsible, but Archer simply dismisses him and turns his face back to the window.
Agree or disagree with the decisions all you like, but the show was not shy about facing some of the possible repercussions of Trip's actions. This could easily have been a show where Archer (or Trip, or someone) makes a big overblown speech about freedom and shames everyone into doing what he wants. He's done it before. Pretty much every captain has, and much of the time I've agreed with him or her. I might even have agreed with it here -- but it doesn't change the fact that the situation really shouldn't have occurred in the first place, and a happy ending would have undercut that point tremendously.
This was a great example of a "why the Prime Directive will show up someday" show. That, combined with especially solid acting from Scott Bakula (during the crunch scenes, anyway), Connor Trinneer, and especially Becky Wahlstrom as the cogenitor, made the core of the show one that's worth occasionally going back to.
I have to hope, though, that we see some real consequences to this in Archer's behavior, or at least Trip's. Trip *should* be a bit less rash now as a result, and personally I'd be interested to see him a lot more likely to side with T'Pol and call Archer on things when he's acting like his beliefs are all that matters. If that doesn't happen, I'll be very disappointed.
Oh, the subplots? Yeah, I should mention those. There were two: Archer and the Vissian captain exploring the star, and Reed winding up in a one-night stand with a Vissian woman. The former was mostly an excuse to get Archer off-ship and to give Bakula something to do, but having the ever-watchable Andreas Katsulas trading dialogue with him helped. (It also made a few points about the Vissians' intellectual capacities that were useful later.) The Reed stuff was pretty much a waste of time.
Other thoughts:
-- Science nit: Captain Danik says that the stratopod's navigation system is based on "five spatial axes." Hard to see how that works -- there are only three spatial dimensions through which a macroscopic object can move and remain in normal space, even in the Trek universe. (Sure, string theory proposes quite a few more, but folded up into microscopic size. Not a big deal, but a slight comment.
-- As long as we're on the science, tri-gender reproduction is a tad dicey. It's certainly not impossible -- it's just hard to imagine how that would have evolved as a successful reproduction strategy. When you move from asexual reproduction to sexual, the advantages of mixing two partners' traits tend to outweigh the various complications involved, so it's persisted for quite a long time now. (I doubt anyone here is complaining too much about that. :-) Moving from two genders to three, however, seems to be something that'll complicate the logistics intensely without adding much more to the offspring's fitness. It's not impossible to see how such a situation might have come about, but it strikes me as something that'd be a lot less common than Phlox implies. (Again, this is not a complaint, just a comment.)
-- It looked to me as though Trip and the cogenitor were playing go for a while after the movie, but I'm not at all sure, not having played it. (I don't think go involves taking pieces off the board, but I could be utterly mistaken there.) If so, it's an interesting choice, as go is a fairly complicated game with a history at least as long as chess -- and we know chess is still around, after all.
-- For those wondering "hey, I've seen that engineer before," F.J. Rio also played the ill-fated Muniz in DS9 seasons 4-5. He was an engineer then, too -- but showed a bit more range here than he had much chance to there, I think.
That's about it. If you can get past some of the initial plausibility problems and a slightly artificial setup, the core story of "Cogenitor" is one well worth the viewing. I'd be intrigued to see the Vissians again a year or two down the line.
Wrapping up:
OVERALL: Call it an 8.5: I'm feeling generous.
NEXT: Must be sweeps time, as the Borg come a'calling.
Tim Lynch (Castilleja School, Science Department) email@example.com <*> "I might have expected this from a first-year recruit, but not you. You did exactly what I'd do? If that's true, then I've done a pretty lousy job setting an example around here." -- Archer Copyright 2003, Timothy W. Lynch. All rights reserved, but feel free to ask... This article is explicitly prohibited from being used in any off-net compilation without due attribution and *express written consent of the author*. Walnut Creek and other CD-ROM distributors, take note.
Hans-Wolfgang Loidl <email@example.com> Last modified: Sun Aug 26 21:35:15 1996 Stardate: [-31]8019.28


text:
David B. Haight was three years short of becoming an apostle of the Lord, Jesus Christ, when he spoke on the "Power of Evil." The warnings were clear then, as they are in full force now, but good will over-power evil.
He mentioned the degradation of society because at the time of this talk evil influences were in neighborhood movie houses; hard-core pornography was easily accessible at candy stores and supermarkets. Hello, 21st Century!! The evil influences are now at our fingertips in any of the 3-4 devices we have laying around. Movies AND hard-core pornography can be viewed without having to leave the comfort of our own private world. Forty-three years ago, he likened his world to a "space-age Sodom and Gomorrah." What would he think of our world now?
The power of evil looks as though it might overpower good. We live in a world that encourages the influences of "false prophets, false Christs, and modern movements of spiritualism … satanic influences because [victims] do not understand or realize the power of the adversary."
Of course, we are all faced with evil, whether we shun it or devour it in tidbits. But aren't we mostly worried for our children? It seems with every passing generation, our children get lost deeper and deeper into the vortex. What example do we set for them to be strengthened, or stand up against, what we know to be any evil monster of spiritual destruction?
I am a big fan of The Relief Society Magazine, a 50-year publication by the Church. The following story can be found in the February 1920 issue about Rachel Ivins Grant (mother of Heber J. Grant).
This story, of an incident that happened in the 1800's, is told by her son, Heber. Rachel, who was a seamstress by trade, was doing some sewing at the William S. Godbe house. Godbe first became disillusioned by Brigham Young, and then started his own church, "The Church of Zion," or "Godbeites," which followed the popular 19th Century interest in Spiritualism.
In the Parlor, a small group was gathered enjoying the novelty of receiving messages from a planchette, or Ouija Board. They called for Rachel to come and join them, but she refused. Heber had come after school and asked his mother about what they were doing. She explained that the prophet had warned never to have anything to do with a planchette, because it will lead you to apostasy, which she told Heber was evident in what she had seen around town.
The group came into the room, with their planchette, and attempted to coerce her once again, but the board didn't seem to be working anymore. They wandered back to the parlor and once again began laughing over the messages they were receiving through the now working board. They again attempted to call upon Rachel to join them. Heber remembered being surprised that she did indeed go into the other room, and immediately the board stopped working once again.
Later on, the two discussed the incident. Rachel explained that she had prayed silently that the planchette would have no power while she was in the room. This worked the first time when it was brought into her room. Asking for protection from the Lord again, she was able to enter the room with the group. She explained to young Heber, "I rebuked its power to work and it could not move, and as you know it did not work in my presence."
The article concluded with these words: "What about your homes, dear friends, and what about your children?" We don't actually use the words good vs. evil so much anymore. The lines are washed out somewhat. Yet, evil still exists and good must overpower it.
We cannot assume that our family will remain untouched by evil. Every household will have to make their decision, teach eternal truths of the gospel that safeguard, and stand firm against the destroyer. Elder Haight stated,
"We are told that some of the 'very elect' will be enticed and deceived. Couldn't this 'very elect' include your sons and daughters, even though through baptism they have already accepted Christ as their Savior? Wouldn't the evil one concentrate on them if he found a weakness or an opportunity?"
Satan does not have the power to destroy us, only if we allow him to. We, however, have greater power that will free us from his chains. We can turn to Jesus Christ for strength to overpower any darkness that comes from evil. Jesus Christ is more powerful, more righteous, more pure, and He loves us more than Satan does. Jesus Christ truly is mighty to save.
Elder Haight spoke for the last time in the April 2004 General Conference. He left us with his testimony:
"I understand the power of prayer and of faith and devotion, and I acknowledge precious witnesses from heaven. … The gospel is true. I know it; I'm a witness of it."
Let us not be deceived, and caught up into false representations. Satan is real, but Jesus Christ and His army will overpower all evil. We are each expected to stand ready and fight the daily battle which faces each one of us. And, according to our faith, we can call upon the powers of heaven where evil can have no effect on us and our loved ones.
Additional posts from General Conference Odyssey participants:
The Greatest Tricks the Devil Plays Nathaniel Givens
God of the Gaps: Do not Cast Yourself off the Temple G
The Joy of Sharing the Gospel Daniel Ortner
Expanding Symmetry Marilyn Nielson


text: Truro street scenes Leave a reply Streetscape. I watched this seagull hop on top of this car. Apparently the water table is high in Truro, since water was running in stone gutters all over town. Yes, I stopped in this candy shop. Not Truro, but Cornwall. Advertisements Share this:FacebookEmailPrintGoogleWhatsAppLinkedInLike this:Like Loading... Related


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Today was day one of camp Harrison. It was Marvelous! Isa and Jimmy could not wait for it to start.
We met Janet and the kids at Oz Park in Chicago. The playground is completely shaded and that couldn't have been more perfect on this hot, hot day. Jimmy found a ladder to climb right away.
Rosie and Isla climbed these stairs a million times. Check out Isla in her 2011 camp shirt. I love it!
Rosie and Isla really played together and were happy to have a partner in crime on the slide.
Jimmy played by himself a lot of the time. He climbed up this one thing so many times and it was like he couldn't stop himself. Eventually I could tell he was physically tired so we had a blueberry break.
Look how happy they are!
Isa and Al!
Olivia was great. She wanted to take Rosie through the park and I let her until a whole 30+ kid camp arrived and then I wanted her in my sight. I'm sure Olivia would have kept her safe though.
Three girls on one side and Isla on the other…hmmm…as Isa would say, "it's not symmetrical."
Al was such a climbing boy at the park. At one point I looked over and he standing on a single post that was there and I can't help but wonder if he will be the next karate kid. I expected him to kick and then land on the other leg. Sadly, my amazement didn't allow any photo taking.
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What did we talk about? The Avatar!
After our picnic, we played: Mr. Fox-what time is it?, Red Light, Green Light, and Mother May I.
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Rosie watched all the games with her bag of Pirate Booty.
Jimmy relaxed in the stroller and watched the games! Rosie got tired of the Pirate Booty and picked up some raisins.
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Back at Janet's house, the kids watched The Wizard of Oz.
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Then we had dinner and went home. I can't wait day two!


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Molecular Oncology Group
Molecular Oncology Group
PubMed | University of Porto, Molecular Oncology Group and Institute Biologia Molecular e Celular Immunobiology Research Group
Type: Journal Article | Journal: Future oncology (London, England) | Year: 2015
Evaluate if serum levels of VEGF and Ang-2 are correlated in non-small-cell lung cancers (NSCLCs) and its implications in the diagnostic and prognostic of the disease.Unselected cohort of 145 NSCLC patients and 30 control individuals. The serum levels of Ang-2 and VEGF of each patient were measured by ELISA prior to treatment.Serum levels of Ang-2 and VEGF are correlated (p < 0.0001). High serum levels of Ang-2 and VEGF isolated and both combined (high(Ang-2/VEGF)) correlate with likelihood of presenting NSCLC (p = 0.016; p = 0.003; p < 0.0001, respectively). Serum levels of Ang-2 and high(Ang-2/VEGF) but not VEGF alone are independent prognostic factors (p = 0.001; p = 0.619; p = 0.005). High(Ang-2/VEGF) serum levels could be exploited as a new valuable integral biomarker in NSCLC.
Malho P.,Comparative Ophthalmology Unit |
Dunn K.,FOCUS EyePathLab |
Donaldson D.,Comparative Ophthalmology Unit |
Dubielzig R.R.,University of Wisconsin - Madison |
And 2 more authors.
Journal of Small Animal Practice | Year: 2013
Objective: To evaluate if 14 genes that discriminate metastasising and non-metastasising human uveal melanomas can differentiate metastasising and non-metastasising uveal melanomas in dogs. Methods: Nineteen archival biopsies of eyes with a histopathological classification of primary benign (n=9) and malignant (n=10) uveal melanoma were selected. Thoracic and/or abdominal metastases confirmed metastatic spread of the primary tumour in seven dogs during the follow-up period. Gene expression was assayed by Reverse Transcription-quantitative Polymerase Chain Reaction. Genes displaying statistically significant differences in expression between the metastasising and non-metastasising tumours were identified. Results: Four genes (HTR2B, FXR1, LTA4H and CDH1) demonstrated increased expression in the metastasising uveal melanomas. Clinical Significance: This preliminary study illustrates the potential utility of gene expression markers for predicting canine uveal melanoma metastasis. The genes displaying elevated expression in the metastasising tumours are part of a 12-discriminating gene set used in a routine assay, performed on fine needle aspirate biopsies collected without enucleation, for predicting human uveal melanoma metastasis. Further work is required to validate the results. © 2013 British Small Animal Veterinary Association.
PubMed | University of Barcelona, Vall dHebron Institute of Oncology VHIO, University of Malaga, Hospital Universitari Of La Vall Dhebron and 3 more.
Type: Journal Article | Journal: Clinical cancer research : an official journal of the American Association for Cancer Research | Year: 2016
Most hormone receptor (HR)(+)/HER2(-) breast cancer patients respond unfavorably to neoadjuvant chemotherapy (NAC); however, genomic tests may identify those patients who are likely to benefit. Using the Prosigna assay, we first evaluated the technical performance of core needle biopsy (CNB) tissues. We then determined whether Prosigna risk of relapse (ROR) score and intrinsic subtype predicted response to NAC in HR(+)/HER2(-) patients using CNB samples.Using the NanoStrings nCounter Dx analysis system and a development tissue sample set, we established tissue requirements and assay output variance. We then evaluated the concordance in subtype and correlation in ROR between CNBs and corresponding surgical resection specimens (SRS) in a second independent sample set. Finally, we analyzed 180 independent CNB samples from HR(+)/HER2(-) patients who were treated with NAC and correlated ROR and intrinsic subtype with pathologic response.Intra- and interbiopsy variabilities were 2.2 and 6.8 ROR units, respectively. Subtype concordance within multiple CNBs was high for the 4- and 3-subtype classifications (k = 0.885 and 0.889, respectively). Correlation in Prosigna ROR score observed between paired CNBs and SRS was high (r 0.90), and subtype concordance was also high for the 4- and 3-subtype classifications (kappa = 0.81 and 0.91, respectively). Prosigna results obtained from the HR(+)/HER2(-) patient samples showed that both ROR (P = 0.047) and intrinsic subtype (OR LumA vs. non-LumA = 0.341, P = 0.037) were significant predictors of response to NAC.Prosigna ROR and intrinsic subtype are readily obtained from CNB samples in normal practice and reliably predict response to NAC in HR(+)/HER2(-) patients.
Coelho A.L.,Molecular Oncology Group |
Coelho A.L.,University of Porto |
Araujo A.M.,Centro Hospitalar Do Porto |
Araujo A.M.,Abel Salazar Biomedical Sciences Institute |
And 9 more authors.
Future Oncology | Year: 2015
Aim: Evaluate if serum levels of VEGF and Ang-2 are correlated in non-small-cell lung cancers (NSCLCs) and its implications in the diagnostic and prognostic of the disease. Patients & methods: Unselected cohort of 145 NSCLC patients and 30 control individuals. The serum levels of Ang-2 and VEGF of each patient were measured by ELISA prior to treatment. Results & conclusions: Serum levels of Ang-2 and VEGF are correlated (p < 0.0001). High serum levels of Ang-2 and VEGF isolated and both combined (highAng-2/VEGF) correlate with likelihood of presenting NSCLC (p = 0.016; p = 0.003; p < 0.0001, respectively). Serum levels of Ang-2 and highAng-2/VEGF but not VEGF alone are independent prognostic factors (p = 0.001; p = 0.619; p = 0.005). HighAng-2/VEGF serum levels could be exploited as a new valuable integral biomarker in NSCLC. © 2015 Future Medicine Ltd.
Nunez de Villavicencio-Diaz T.,Bioinformatics Group |
Mazola Y.,Bioinformatics Group |
Perera Negrin Y.,Molecular Oncology Group |
Cruz Garcia Y.,National Institute of Oncology and Radiobiology of Cuba |
And 2 more authors.
Biochemistry and Biophysics Reports | Year: 2015
CK2 is a constitutively active Ser/Thr protein kinase deregulated in cancer and other pathologies, responsible for about the 20% of the human phosphoproteome. The holoenzyme is a complex composed of two catalytic (α or αD') and two regulatory (β) subunits, with individual subunits also coexisting in the cell. In the holoenzyme, CK2β is a substrate-dependent modulator of kinase activity. Therefore, a comprehensive characterization of CK2 cellular function should firstly address which substrates are phosphorylated exclusively when CK2β is present (class-III or beta-dependent substrates). However, current experimental constrains limit this classification to a few substrates. Here, we took advantage of motif-based prediction and designed four linear patterns for predicting class-III behavior in sets of experimentally determined CK2 substrates. Integrating high-throughput substrate prediction, functional classification and network analysis, our results suggest that beta-dependent phosphorylation might exert particular regulatory roles in viral infection and biological processes/pathways like apoptosis, DNA repair and RNA metabolism. It also pointed, that human beta-dependent substrates are mainly nuclear, a few of them shuttling between nuclear and cytoplasmic compartments. © 2015 The Authors.
Watrowski R.,University Hospital Freiburg |
Watrowski R.,Molecular Oncology Group |
Castillo-Tong D.C.,Molecular Oncology Group |
Wolf A.,Molecular Oncology Group |
And 4 more authors.
Anticancer Research | Year: 2015
Background: The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cancer (BC) is associated with impaired prognosis. Data concerning the HER2 codon 655 polymorphism (Ile/Val) and BC risk are conflicting. Materials and Methods: We studied the HER2 codon 655 (rs1136201) polymorphism in 80 Austrian patients with BC and 100 healthy volunteers by pyrosequencing and polymerase chain reaction. Associations between codon 655 allelic variants and clinicopathological variables (e.g. age, stage of disease, tumor type, grading, and receptor status) were studied with 22 tables. Results: The genotypic distributions in patients with BC (AA: 63.75%, AG: 32.5%, GG: 3.75%) and controls (AA: 63%, AG: 34%, GG: 3.7%) were virtually identical (odds ratio=1.03, 95% confidence interval=0.56-1.90). A non-significant link between carrying at least one G allele and more aggressive tumor type (estrogen receptor-negative p=0.08, G3 tumor p=0.19) was observed. Conclusion: Genotypic variation within the codon 655 of HER2 does not alter the BC risk in Caucasian Austrian women. The association between the G allele and more aggressive tumor types requires further investigation.
PubMed | Cancer Research UK Research Institute and Molecular Oncology Group
Type: Case Reports | Journal: Annals of oncology : official journal of the European Society for Medical Oncology | Year: 2015
Chronic myeloid leukaemia (CML) is characterised by the presence of a fusion driver oncogene, BCR-ABL1, which is a constitutive tyrosine kinase. Tyrosine kinase inhibitors (TKIs) are the central treatment strategy for CML patients and have significantly improved survival rates, but the T315I mutation in the kinase domain of BCR-ABL1 confers resistance to all clinically approved TKIs, except ponatinib. However, compound mutations can mediate resistance even to ponatinib and remain a clinical challenge in CML therapy. Here, we investigated a ponatinib-resistant CML patient through whole-genome sequencing (WGS) to identify the cause of resistance and to find alternative therapeutic targets.We carried out WGS on a ponatinib-resistant CML patient and demonstrated an effective combination therapy against the primary CML cells derived from this patient in vitro.Our findings demonstrate the emergence of compound mutations in the BCR-ABL1 kinase domain following ponatinib treatment, and chromosomal structural variation data predicted amplification of BCL2. The primary CD34(+) CML cells from this patient showed increased sensitivity to the combination of ponatinib and ABT-263, a BCL2 inhibitor with a negligible effect against the normal CD34(+) cells.Our results show the potential of personalised medicine approaches in TKI-resistant CML patients and provide a strategy that could improve clinical outcomes for these patients.
Pereira C.,Molecular Oncology Group |
Pimentel-Nunes P.,Portuguese Institute of Oncology |
Brandao C.,Portuguese Institute of Oncology |
Moreira-Dias L.,Portuguese Institute of Oncology |
And 4 more authors.
European Journal of Gastroenterology and Hepatology | Year: 2010
Objective: COX-2, the inducible isoenzyme, was found to be overexpressed in approximately 85% of colorectal adenocarcinomas, contributing to key steps in tumor development. COX-2 polymorphisms that might modify the levels of protein expression would be anticipated to have a substantial influence on disease phenotype. Therefore, we sought to understand the role of three COX-2 polymorphisms (-1195A>G, -765G>C, and 8473T>C) in colorectal cancer (CRC) onset. Material and Methods: We conducted a hospital-based case-control study involving 117 consecutively enrolled CRC patients and 256 healthy individuals without any clinical evidence of cancer. The COX-2 polymorphisms genotypes were characterized by PCR-restriction fragment length polymorphism or real-time PCR techniques. Results: The -1195A>G polymorphism was associated with a 1.73-fold increased predisposition to CRC onset. In a stratified analysis, men and ever-smokers carrying -1195G allele (AG+GG) had an increased risk for CRC development (odds ratio: 2.58; 95% confidence intraval: 1.29-5.15 and odds ratio: 10.3; 95% confidence intraval: 3.37-31.2, respectively). More interestingly, men ever-smokers carrying -1195G allele appeared to have a nine-fold increased risk for CRC onset (95% CI: 2.94-27.6). No difference in the genotype's distribution was noticed between cases and controls for the remaining two polymorphisms. Conclusion: The -1195A>G COX-2 polymorphism seems to modulate the genetic susceptibility for CRC onset, especially in men ever-smokers. This genetically based higher-risk group definition may help shift the balance between risk and benefits for the use of COX-2 inhibitors in chemoprevention that is currently hampered by the adverse gastrointestinal and cardiovascular side-effects. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.


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November 2013
29 Nov'13
If only the food was...
Housed in a 19th century building located in the vibrant district, El Born, Senyor Parellada is a restaurant that specialises in traditional Catalan cuisine. And despite its unassuming exterior, the restaurant's interior is beautifully decorated and has a nice ambience. My partner and...Read More
27 Nov'13
Luxury has a new address...
Spreading over an impressive 1,060m2, Bottega Veneta brings luxury shopping to the next level. Located in the upmarket via SantÁndrea 15, the Italian fashion brand's first maison carries the most extensive range of its fashion and lifestyle products including men and women's ready-to-wear, leather...Read More
26 Nov'13
Heavenly hammam – Purovel Spa...
No self-proclaimed spa junkie would leave Turkey without trying the hammam, or turkish bath, especially when he is in Istanbul. Hence, before I left Singapore for my Istanbul trip, I've made an appointment to experience my first authentic hamman at Purovel Spa and Sport located...Read More
25 Nov'13
Re-live childhood memories – Bianco...
It was a cold November morning in 2009 when I discovered Bianco Latte, a café and restaurant located at via Turati, Milan. It was my second trip to Milan and was staying at the nearby Westin Palace hotel. Since I wasn't able...Read More
22 Nov'13
Mouth-watering food at affordable prices...
It was slightly before noon and Mercat de Santa Caterina was still bustling with activities. My partner and I saw a packed bistro located within the market. It has bar seating, and serves reasonably priced food. Upon closer look at its menu,...Read More
20 Nov'13
Mesmerised by her grace and...
From the moment I stepped into the hall, she captured my attention. Her steps are so energetic and yet her movement is fluid and elegant. She is so alluring that she kept me spellbound the whole time. My eyes are locked on...Read More


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A district attorney prosecutes cases on behalf of the public. District attorneys manage the prosecutor's office and play a central role in investigating charges, deciding whether to charge someone with a crime, offering plea bargains, and litigating appeals. They also advise parole boards on inmate requests for early release.
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text:
Chinese regulator for Citigroup`s expansion in China: Report
A top Chinese regulator for foreign banks has said Citigroup should expand its local operations in China, according to a media report.
New York: A top Chinese regulator for
foreign banks has said Citigroup should expand its local
operations in China, according to a media report.
Citi`s China unit was "very prudent and careful" amid the
global financial crisis and now should be "expanding,
absolutely," Yan Qingmin who is the director of the Shanghai
branch of the China Banking Regulatory Commission and one of
the top regulators for overseas banks told The Wall Street
Meanwhile, last week a media report noted that Citigroup
is scaling back its operations in the US to only six major
metropolitan areas.
Yan said Citigroup should take advantage of growth in the
Chinese economy and expand in the world`s most populous
He said Washington`s support for Citigroup was the
correct decision and the result has done little to alter how
Chinese policy makers regard the financial services giant.
"Regarding the US government bailout of Citigroup, I
think the American government measures were urgently needed,"
he said to the WSJ, adding, "They were very timely. At that
moment, what we needed most was confidence".
The comments suggest that Washington`s 34 percent stake
in Citigroup, amassed after offering USD 45 billion in support
this year, is not a worry for Chinese regulators, and perhaps
is a source of comfort.
China`s own banking industry is controlled by the state,
with a Communist Party appointee at the helm of major
The report noted that Citigroup`s global operations lost
USD 27.68 billion in 2008, but its business in China remained
healthy. Net profit from its China operation, which includes
stakes in local banks, nearly doubled last year to the
equivalent of USD 191 million.
According to the publication, Citigroup has expanded its
base in China over the past year, but not as much as other
foreign banks.
At the end of June, its loan-to-deposit ratio of just USD
6 in loans for every USD 10 in deposits was among the most
conservative in the industry, he added.
The report citing a statement from Citigroup said "China
remains one of Citi`s top priority markets anywhere in the
world. Our business in China is performing strongly and we
continue to pursue growth across all lines of business."
Bureau Report


text:
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text: greenish blue definition October 15, 2017 AZ Dictionary Link to this page noun: a shade of blue tinged with green Related Sources Definition for "greenish blue" a shade of blue tinged with green View More Hypernym for "greenish blue" blueness View More How would you define greenish blue? All the definitions on AZdictionary were written by people just like you. Now's your chance to add your own! Your Full Name Your definition Post Definition


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Multiple color coded wires jacketed in a single sleeve for easy gauge wiring. Sold in 1 meter length (39").
Note: Image for reference only. Use 9 conductor cable for Motogadget Motoscope Tiny and Pro. Use 6 conductor cable for Motogadget Motoscope Mini. Classic and Chronoclassic models may be configured for 6 or 9 conductors depending on desired function, refer to instructions.
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Format: Print Length
Language: English
Format: PDF / Kindle / ePub
Size: 11.29 MB
Downloadable formats: PDF
Pages: 321
Publisher: Atria Books; Reprint edition (July 14, 2015)
Timescanner: The Future Has Been Postponed
Everybody's After Love
Neither even mentions feelings of superiority. The Relief Theory is an hydraulic explanation in which laughter does in the nervous system what a pressure-relief valve does in a steam boiler. The theory was sketched in Lord Shaftesbury's 1709 essay "An Essay on the Freedom of Wit and Humor," the first publication in which humor is used in its modern sense of funniness , e.g. The Sheriff Takes a Wife (Nottingham Tales Series Book 2) download pdf. The Shoah, the gift that keeps on giving. As researchers look east, some are studying the role of Muslims recruited to the Waffen-SS in Yugoslavia. Up to 42,000 Muslim SS members and police troops were recruited by the Nazis, and thousands of them participated in the slaughter of Jews and Orthodox Christians in Bosnia and Serbia, respectively epub. They massage the prejudices of the middle class. And so they're popular and people like them. But "Husbands and Wives" is much better than both of those films. "Zelig" is a better people liked at the time and "Manhattan" as well , e.g. My Inflatable Friend: The download for free katuru.info. Rashi is an acronym for Rabbi Shlomo ben Yitzchok, a major Biblical French commentator (1040-1105). 3. Abraham Ibn Ezra, Spanish poet, philosopher, and Biblical commentator born in Toledo, Spain (1080-1164). 4 , source: Guardian Quest: Book 13 in the Quest Series download pdf. We could say that this is the satirist's practical application of Christ's injunction to love our enemies (Matthew 5:44, Luke 6:27-28), because genuine concern for another's welfare when it does not affect us personally is one of the basic indications of disinterested love. Pope affirms in several of his poems that his concern for man and virtue is disinterested Skyjackers - Episode 5: Beaten to the Punch (Skyjackers: Season One) download online. It is no surprise then that a transmedia project currently in development called the Black Body Survival Guide, uses humor and satire in presenting a series of survival tips for black and brown bodies , source: The Richest Man In New York: A Short Story http://tellfredericksburg.com/freebooks/the-richest-man-in-new-york-a-short-story. Free reading online and free download in EPUB available Brains: A Zombie Memoir download online download online. Out trusty camera captured the event in a night-vision mode, complete with the sermon and a short interview with Mother Moonbat herself. She was apprehensive at first, but when we said we represented a socialist Karl Marx Treatment Center, she smiled and relaxed... As Americans are trying to come to grips with nature's attack on the Gulf Coast, reports are growing about an increased level of hate crimes against environment in US cities and rural areas , e.g. The Cerulean Stone: A Will read pdf http://tellfredericksburg.com/freebooks/the-cerulean-stone-a-will-hawthorne-short-story.
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Market Knowledge, Evaluation & Forecast Studies & Companies
A virtual place to discuss between specialists the most recent information about automotive electronics, hybrid and electrical automobiles, communication linked to mobility. Effectively you want hand instruments and a hoist at a minimal, and past which you could read find out how to set up an auto repair shop on my hubs. Automotive Lifts: Hydraulic lifts are very common within the industry and are used in showrooms, restore shops, and car factories. We use the newest digital reality expertise to ship automobile clinics in a complete new way, offering better insights sooner. The Millennium Era are growing up in a time when there's an unprecedented availability of all kinds of know-how.
You can too hear for the gasoline pump's buzzing sound when the secret is first turned on. Additionally if a inoperative gas pump is suspected, a superb technician will always check to confirm there's power and floor being supplied to the pump, to eliminate the opportunity of a bad relay or electrical situation. However, there's a limit to how simple it's to a button using the contact display keyboard will be in comparison with having a real physical keyboard. The aim of a circuit may be to operate a light-weight bulb, a sensor, an actuator, a fan, or another appropriate automotive electrical machine. Many automotive DMMs now come with auto-ranging capability as a standard feature.
There are numerous superior artists on the market that may create crazy, insane and amazing artwork. Nevertheless, when it come to painting it on a automobile paint finish, many individuals lack the knowledge of what steps they need to observe to guarantee a high quality job that won't peel off later. Another key message was the significance of electronics in cars for this business and its suppliers and the necessity to carry the brand new actors in automotive and electronics collectively. They'll have the compatible supplies and expertise to do the repair correctly. There is a historic body of information that has been amassed as the computer know-how discipline has developed. There high quality of labor will present in there comebacks which they often don't receives a commission for to restore a second time. We've got both the assets and experience to supply a highly competitive edge in automotive logistics across the globe.
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How much does a Associate Software Engineer at CallidusCloud make in San Jose, CA? The typical salary for a CallidusCloud San Jose Associate Software Engineer ranges from $84,802-$95,308, with an average salary of $92,682. Salary estimates based on 4 salary report(s) submitted anonymously to Glassdoor by CallidusCloud Associate Software Engineer employees in San Jose, CA or estimated based upon statistical methods.
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- Farhad Montazeri, Arash Bedayat, Layli Jamali, Mehran Salehian, Ghoderat Montazeri
- European Journal of Pediatrics
- 2008
We report the case of an 11-year-old boy who presented with fresh blood in his mouth and a history of sore throat during the past 2 weeks that was unresponsive to antibiotic therapy. Inspection of the oral cavity revealed a black circular mass attached to the posterior wall of the oropharynx. This mass was determined to be a live engorged leech. Leech… (More)
- Naomi Hauser, Zuhal Arzomand, +4 authors Richa Tandon
- IDCases
- 2015
BACKGROUND African tick bite fever (ATBF) is an emerging infection endemic to sub-Saharan Africa and increasingly noted in travelers to the region. CASE REPORT We present a case of ATBF in a 63-year-old man who presented with complaints of a rash and fever to the emergency department. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Rickettsial… (More)
- Gabriel Brooks, Jenny Hong Gao, +6 authors Joseph O Jacobson
- Journal of clinical oncology : official journal…
- 2013
3 Background: Palliative chemotherapy is aimed at improving quality of life and increasing life expectancy, without curative intent. Toxicity during palliative treatment defeats the goal of care and increases healthcare cost. We describe the predictors of CRHs among cancer patients treated for palliative intent at a community cancer center. METHODS We… (More)
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