text: Long-term Outcomes After Gamma Knife Radiosurgery for MeningiomasKondziolka, Douglas MSc, MD; Patel, Agam D. BA; Kano, Hideyuki MD, PhD; Flickinger, John C. MD; Lunsford, L. Dade MDAmerican Journal of Clinical Oncology: October 2016 - Volume 39 - Issue 5 - p 453–457 doi: 10.1097/COC.0000000000000080 Original Articles: Central Nervous System Abstract Author Information Background: Gamma knife stereotactic radiosurgery (SRS) has become an important management strategy for patients with meningiomas. Although prior reports have studied early tumor control, neurological response, and associated morbidity, our purpose was to use clinical and imaging studies to determine whether long-term outcomes remain stable over time. Materials and Methods: We studied 290 consecutive patients (92 men and 198 women) who underwent gamma knife SRS for a meningioma between 1987 and 1997. The median tumor margin dose was 15 Gy and the median tumor volume was 5.5 mL. Target definition was performed using contrast enhanced computed tomography in 72 patients and magnetic resonance imaging in 218 patients. The median patient age at radiosurgery was 61 years. Twenty patients had a history of fractionated radiation therapy, 136 patients had undergone a subtotal resection, and 22 patients had recurrences after initial gross total resection. Results: The overall tumor control rate was 91%. Twenty-six patients (9%) had evidence of delayed local tumor growth and 44 (15%) had regional tumor progression, which occurred at a median of 38 months. The 10- and 20-year actuarial rates of freedom from tumor progression of the targeted tumor were 87.7%±2.5% and 87.2%±4.2%. Of 234 patients who had symptoms before SRS (n=62, 26%) improved, 126 (54%) had no change in symptoms and 46 (20%) gradually worsened. Thirty-two of 34 (94%) asymptomatic patients remained asymptomatic. We found no difference in long-term tumor control rates between patients who had undergone craniotomy before radiosurgery (89%) and patients who underwent primary radiosurgery (93.1%). Adverse radiation effects were detected in 3.1% of patients. Factors associated with worse progression-free survival included prior radiation therapy (P<0.0001) and higher grade meningioma (P<0.0001). At a median of 8.7 years after SRS, 137 patients were dead at a median age of 77 years. Conclusions: We found that gamma knife SRS provided durable tumor control with low morbidity in meningioma patients. *Department of Neurosurgery, NYU Langone Medical Center, New York, NY Departments of †Neurological Surgery ‡Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA L.D.L. is a consultant and directly purchased shareholder in AB Elekta. The remaining authors declare no conflicts of interest. Reprints: Hideyuki Kano, MD, PhD, Department of Neurological Surgery, University of Pittsburgh, Suite B-400, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213. E-mail: email@example.com. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.


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Monthly Archives: September 2015
Best Web Services for an Entrepreneur
The emergence of a large number of entrepreneurs in the field of technology has made a huge impact in the internet. With them not only being successful and making a lot of money with their innovations many people now have aspire to become such techno entrepreneurs.
Particularly in the internet many entrepreneurs with their innovative websites like social networking sites, online merchant services, information file sharing sites and many more alike have become millionaires. Hence having an innovative website is the new trend in the internet and for that good web content, unique features and an attractive design are needed.
Anyhow, a good web hosting provider ranks above all of them as only if the website is hosted with the best web hosting service provider the website can be made available in the internet after it being so excellently designed and developed. A good web hosting provider shall provide ample storage space with very good power back up for efficient uptime.

subset: commoncrawl


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UCLA Study: Pancreatic Cancer Loves Fructose, Controversial Sweetener
As Americans' consumption of high-fructose corn syrup -- a corn-based sweetener found in sodas and other processed foods -- has skyrocketed, so has our propensity to become obese and develop diabetes.
Not surprisingly, corn growers and the food industry have fought a preventive war against any notion that HFCS consumption and those epidemics are related, with an expensive, and not always unpersuasive, ad campaign. But an entirely new problem seems to have arisen for the sweet, sweet HFCS.
UCLA reports: Pancreatic cancers use the sugar fructose, very common in the Western diet, to activate a key cellular pathway that drives cell division, helping the cancer grow more quickly...
Although it is widely known that cancers use glucose, a simple sugar, to fuel their growth, this is the first time a link has been shown between fructose and cancer proliferation, said the study's senior author, Dr. Anthony Heaney, an associate professor of medicine and neurosurgery and a Jonsson Cancer Center researcher.
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Heaney said his findings show "Cancer cells can readily metabolize fructose to increase proliferation." There's no reason to expect different results in different types of cancers, he said.
The research will be published in the journal Cancer Research. (The research was funded in part by the National Institutes of Health, which is ironic given how much we subsidize corn, though the same was once true of tobacco.)
Heaney said the research has significant public health ramifications: "Hopefully, at the federal level, there will be some effort to step back on the amount of HFCS in our diets." Has Heaney seen "The Insider"? Because that's the power the food industry will bring to bear on him and his research, assuming it stands up to peer review.
Should be interesting to watch this play out in the coming years, er, decades.
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Whether you're cleaning the house, cooking for yourself, or caring for animals, it's important to keep certain foods or substances away from dogs, cats, or other pets. Just like small children or babies, there's a chance that pets will put stray items in their mouths. Some examples include milk for cats, chocolate and macadamia nuts for dogs, and caffeine for all animals. Check out the infographic below to find out the other kinds of food your pets should avoid:
(Via: Design Taxi)


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Seven months ago, Sufjan Stevens released his acclaimed album Carrie & Lowell. Many fans were pleased that he returned to his folk roots following a few projects that were more electronic and experimental. Recently, however, he reveals that he hasn't completely abandoned the sound yet, releasing a remix of album cut "Blue Bucket of Gold." The rework does not take away from the original's haunting elements; the echoing drums and mesmerizing synth-work adds to it. Listen to the remix below.
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Holistic Therapies....
This is a natural, safe and gentle holistic therapy that helps restore the body's inner strength. It balances body and mind, restoring health and harmony.
There are reflexes in the feet and hands that mirror every gland, organ and part of the body.
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Save up to $800 per couple!!!
For a limited time only save up to $800 per couple on this remarkable journey to Machu Picchu & Galapagos. Reserve by October 5, 2017 to qualify for the early booking discount. Space is limited so please reserve early.
|Itinerary at a glance
|Tour Highlights
|Your tours of Machu Picchu include
Click on the tabs below to learn more!
Guided Tour Pricing
Pricing includes land and airfare
(Land only pricing available upon request)
Best Value Pricing
Reserve after
After Sale
Oct 21
Nov 5
$ 6199
$ 6299
$ 6599
Nov 18
Dec 3
$ 5999
$ 6099
$ 6399
|Rates are per person based on double occupancy.
Single room supplement is $1849
|For more information on this tour, please contact us here or call us during business hours (Mon-Fri, 9:30-5:30 EST) at 800-337-7773.
|Important Travelers Note
The high altitudes reached on this trip (Cuzco is at 11000 feet above sea level) and the amount of walking involved, often on uneven terrain, requires that you be in good physical condition to fully enjoy the trip. We strongly suggest that you consult a physician regarding any concerns prior to making a reservation.
|Reservations and Payments
Reservations can be made by phone (1-800-337-7773) and will be confirmed upon receipt of $300 per person non-refundable, non-transferable deposit (by check) which must be received within 7 days of reservation. Full payment is due 90 days prior to departure. Baggage fees may apply. Space and prices subject to availability. For complete booking information and terms & conditions click here.
Click here for the 9 Day Ecuador & Galapagos Cruise!
Known throughout the world for its amazing ruins and stunning location high in the mountains, Machu Picchu was accidentally discovered in 1911 by the American archaeologist Hiram Bingham. The beauty of its location and the genius construction make Machu Picchu – "lost city of the Incas" – the archaeological jewel of South America. Machu Picchu´s remains are comparatively well preserved because the Spaniards never reached the city. It was buried in the jungle for centuries, and even after its 1911 rediscovery, the city remained inaccessible until the 1940s, when an archaeological expedition working at the site discovered the Inca Trail cutting through the valley below. While most visitors spend only a few hours here, you'll stay overnight and have ample time to absorb the mystery and beauty of this amazing, not-to-be-missed site!
Welcome to the enchanting Galapagos Islands, a magical place like no other on earth! Charles Darwin turned these fascinating isles into a unique living laboratory to study evolutionary changes that led to a new understanding of life on earth. In order to protect the ecological balance, the number of visitors to the islands is limited. You'll be one of those privileged guests to visit the islands and get to know a wide variety of exotic wildlife unique to this archipelago! Get close to animals less fearful of humans than those found elsewhere. This is a once in a lifetime adventure you'll never forget!
The newly-renovated M/V Santa Cruz II is one of the finest ships in her class to sail the Galapagos archipelago. The cruise ship offers excellent standards, including first class service, expert crew, knowledgeable multilingual naturalist/guides and menus that feature tasty international cuisine and celebrated Ecuadorian dishes. It has capacity for ninety guests. The onboard Expedition Team consists of a Chief Naturalist and seven other Naturalists. The Naturalist team will delight guests with diverse natural history explanations, superb on-deck talks, and eye-opening lectures regarding the special Galapagos Islands. All cabins maintain the same high standard for both comfort and style. All cabins have large windows, and the entire ship is air-conditioned.
Click here for the 9 Day Ecuador & Galapagos Cruise!
Later in the day, you'll visit Puerto Egas, a black sand beach with spectacular rock formations in the background. Walk along a trail that crosses the dry interior where marine iguanas are scattered around and the remains of a salt-mining enterprise can still be seen. Continuing down the trail will lead you to the Fur Seal Grotto, one of the few places in the Galapagos where fur seals can be seen. Later, you can swim and snorkel in search of octopuses, sea horses, starfish and other magnificent sea life. (B,L,D)
Day 9
On a guided morning tour of Quito learn about its colonial past, history and culture. Visit the old town and see the Church of San Francisco, the first religious building constructed in South America by the Spanish. See the facade of La Compania, the city's most ornate church. Admire the spectacular views of the Valley of Tumbaco. On a clear day, you'll see the impressive volcanoes surrounding the city. Afterwards, drive north to the Equator and experience the Intiñan Museum, which features interactive exhibits on indigenous ways of life as well as interesting middle of the world experiments like balancing an egg on a nail. The rest of the day is at leisure. (B)
Day 10
After an early breakfast, fly to the island of Baltra, one of the gateways to the islands. Over the next five days cruise along and visit the enchanted Galapagos Islands, where you'll see a variety of exotic wildlife. Board your upscale cruise boat, your base while exploring the islands and enjoy a welcome lunch onboard. This afternoon, enjoy a guided shore excursion of Las Bachas, a wet landing on a white-sanded beach backed by a saltwater lagoon, located at the northern coastline of Santa Cruz Island. Here, you will encounter an amazing variety of sea birds, marine iguanas, and turtles. Later, you'll have a chance to swim and snorkel at the nearby white-sand beach. Reboard the ship and enjoy dinner onboard. MV Santa Cruz II (B,L,D)
Day 11
After breakfast, disembark your ship near Santiago Island, a spectacular island consisting of two overlapping volcanoes. Begin by exploring Buccaneer Cove, a popular site for pirates, sailors, and whalers in the 17th and 18th centuries. Buccaneer Cove is known for its impressive 50 meter tuff cliffs, a dramatic landscape made even more impressive by hundreds of seabirds perched on top of the cliffs. Two of the more recognizable rock formations are known as "The Bishop" and "Elephant Rock." You'll have the opportunity to snorkel or take a boat ride, but don't forget to keep an eye out for the many sea lions relaxing by the beach.
Later in the day, you'll visit Puerto Egas, a black sand beach with spectacular rock formations in the background. Walk along a trail that crosses the dry interior where marine iguanas are scattered around and the remains of a salt-mining enterprise can still be seen. Continuing down the trail will lead you to the Fur Seal Grotto, one of the few places in the Galapagos where fur seals can be seen. Later, you can swim and snorkel in search of octopuses, sea horses, starfish and other magnificent sea life. (B,L,D)
In the afternoon, make your way to the breathtaking Bartholomew Island, a volcanic island where black lava fields contrast with lush green vegetation and spectacular white sand beaches. Enjoy the beautiful beach or hike to the summit of the island where you'll enjoy an impressive view of the surrounding islands. During the hike, you will pass by marine iguanas, lava lizards, and more. At the summit, marvel at Pinnacle Rock, the remains of an eroded tuff cone, leans into Bartholomew's northern bay and provides one of the most recognizable landmarks in the Galapagos Islands. You will also encounter small, friendly companions: the Galapagos penguin, the only existing species of penguin in the equator area. (B,L,D)
Later, visit Darwin Bay, a spectacular byproduct of a submerged crater surrounded by steep cliffs. Here you will observe hundreds of birds, mainly great frigate birds, blue-footed and masked boobies, lava gulls, herons, finches, and mockingbirds. Hike along a magnificent trail, enjoy the beach, or snorkel along the cliffs while looking for colorful tropical fish, golden rays, and perhaps even hammerhead or Galapagos sharks. (B,L,D).
Check out these videos of recent smarTours experiences in Machu Picchu and the Galapagos!!
Trip Preparation
The high altitude reached on this trip (Cuzco is at 11,000 feet above sea level) as well as the considerable amount of walking involved, often on uneven terrain, requires that you be in good physical condition to enjoy this trip. We strongly suggest that you consult with your physician regarding any concerns as well as possible medications to ease the effects of the high altitude. Immunizations are NOT currently required; however, you may wish to consult your personal physician or local public health authorities as to their suggestions.
Your departure flight to Peru and return flight from Ecuador are via LATAM Airlines (operating as LATAM Airlnes Peru and LATAM Airlines Ecuador). You should check-in for your flight at least 3½ hours before the scheduled departure. Please keep in mind that flight schedules are always subject to change. The current departure and return schedules are as follows:
Departure Date
Depart Miami (MIA)
Return Miami (MIA)
2017: Oct. 21, Nov. 18
|LATAM Airlines
LAN Airlines (Lan Chile/Lan Peru/Lan Ecuador Airlines) does not accept advance seat assignment. Actual seat assignment will be provided at the airport. Please note that smarTours is not involved with your seat assignments.
You must be in possession of a passport valid for at least 6 months after the date of return. American passport holders do not require a visa. Non U.S. citizens should check with the respective consulates as to the most current visa requirements to all their travel desitnations. It is your responsibility to obtain the necessary travel documents before the trip.
Your airline tickets along with final instructions and travel tips will be sent to you 10 – 7 days before the scheduled departure of your tour. Please make sure to advise us in writing in case of a change of your address.
Since Peru and Ecuador are located near the equator, the weather is temperate with average daytime high temperatures ranging from 60's to the 80's. However, in areas of higher elevations (Cuzco, Machu Picchu, Quito) as well as in the Galapagos Islands, morning, late afternoon and evening temperatures will be considerably cooler (30's to 50's).
You may dine at either of the hotels used on this tour or other nearby restaurants recommended by your guide. Average cost for dinner (excluding drinks) in the hotel's coffee shop is about $20-25 per meal per person. Your hotel will accept credit cards for your non-included meals.
Hotels and some stores accept major credit cards. However, for "street shopping" you will need local currency or U.S. dollars. Your hotels will be able to exchange your cash to local currency. It is recommended that you bring along cash in small denominations. The official currency of Ecuador is the US dollar!
Each passenger may bring one piece of checked-in luggage (maximum of 44 lbs.) and one carry-on piece. We recommend that you do not over-pack and that you take a variety of separates with climate and comfort in mind.


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Whether it was Abraham Lincoln's talk of the US being the world's "last best hope", Jackson Turner's celebration of the American frontier and its role in the creation of democracy, or Ronald Reagan's portrayal of the country as a shining city atop a hill, there is a tendency to view the US as being exceptional. Every state within the country would no doubt also like to imagine itself as being unique, possessing some kind of distinctive feature for which it is known around the world.
Delaware's courts are known for their expertise on handling complex business disputes without a jury
Some states are more successful in this than others. That Texas is an exceptional state – be it for good or bad reasons – is beyond doubt. Massachusetts and Virginia both played a defining role in the history of the US, while California has such a strong identity it is often spoken of as if it were an entirely different country. Other states, however, are not so lucky.
The first state Delaware holds the distinction of being the first state in the country to have signed the US Constitution. This, officially, makes it the first state in the country – and Delawareans are proud of that fact. The state slogan is "it's good being first", yet this distinction is easily overshadowed by the role other states played in the long saga of the War of Independence and founding of the US. Much more attention and praise is given to the pivotal role played by other, surrounding states during this era: from Pennsylvania, being the birthplace of the constitution, to Virginia, for supplying its most important framers.
The primary reason Delaware holds the title of being the first constitutional signee is due to its size: the small state was eager to sign the document that conferred equal senate representation to all states, regardless of population or area. Size, then, is also something Delaware has tried to leverage to make it stand out from the other states.
Delaware officials have attempted to use its status as a small state to craft a unique image, labelling it the 'small wonder' on highway signs. Vice President Joe Biden, who previously served as a senator for the state, affectionately refers to it as "my little state of Delaware". Yet the state cannot lay claim to being the smallest state in the country – while not the most desirable title, this would at least afford Delaware some additional charm. Rhode Island, however, has snatched that honour from Delaware's grasp.
Delaware, however, is unique in another way: businesses seem to really like the state. Disproportionate to its size, it is the home of more than one million companies. In total, a staggering 64 percent of Fortune 500 companies based in the US – including heavyweight brands such as Coca-Cola and Apple – are incorporated there. Coke's official home may be in Atlanta, but it has still chosen to reside in Delaware.
According to a joint report by the state's Division of Corporations and the Delaware Department of State, Delaware "has become almost a brand name for the 'business' of serving as the official home for corporations". It may seem odd how such a small state – seemingly inconsequential, other than for its constitutional eagerness more than 250 years ago – should be such a favoured destination for businesses (see Fig 1). But there could be a logical explanation.
Courts of chancery
Delaware has made a conscious effort to foster a pro-corporate and business-friendly regulatory environment and tax regime. One of the unique features of business law in the state is the continued existence of the Delaware Court of Chancery, which is a huge attraction to corporations looking for a new place to base their operations. Courts of chancery are institutions with history stretching back to the Middle Ages; they first appeared in 14th-century England, and were intended to arbitrate on commercial affairs. Many were incorporated into general courts in the 19th century, but Delaware's was not. Instead, it continued to stand alone as a separate body. As Delaware's Division of Corporations noted in its report, one major attraction for businesses incorporating in Delaware is its courts, and "in particular, Delaware's highly respected corporations court, the Court of Chancery".
These courts are known for their expertise on handling complex business disputes without a jury. Experts in corporate law decide the case according to Delaware's own unique laws, which have often been structured to offer an even more accommodating environment for business to operate in.
"Delaware law requires, and the Court of Chancery enforces, that a company's directors must always be trying to maximise profits for shareholders", said Lawrence Hamermesh, a professor at Delaware Law School at Widener University, as reported by The Atlantic. Delaware often pushes for even more corporate friendly laws. "In 2009, for instance, concerned that it was losing 'pre-eminence' in corporate litigation, Delaware passed a law allowing litigants with more than $1m at stake to try cases in the Court of Chancery in closed arbitration proceedings, meaning that the public would never know what had happened."
However, even when challenged, the institutions of the state remained steadfast: "The Court of Chancery took a public stance on the matter, arguing that there was no reason the public should have access to all hearings", according to The Atlantic.
Added to this is the low tax rate enjoyed by those domiciled in the state: there is no state tax, nor is there any income tax. If a business is located
in Delaware – even if it is operating across state lines – it is not subject to tax on in-state purchases. The state also has no property tax, no taxes on inheritance, stock or share transfers, or even value-added tax. Specifically for corporations, however, the state has a small franchise and limited liability company (LLC) tax. As Investopedia noted: "Most states require annual franchise and LLC taxes based on earned income. Delaware, however, offers a flat fee franchise tax of $100 and a flat fee LLC tax of $250. Compared to other states, Delaware offers exponentially lower franchise taxes and LLC taxes."
State vs national interest
According to some, Delaware's unique laws and consequent appeal to corporations is undermining other states. As one article in The Atlantic put it, Delaware "profits from this race to the bottom today. The rest of the country, however, isn't making out quite as well". Yet at the same time, from Delaware's perspective, such policies are necessary. Compared to many other states, such as Texas and other oil states, Delaware has little in the way of natural resources. Nor does it have a large and sprawling university complex producing top-level graduates, as California and Massachusetts do, which in turn allows these states to become top centres for health and technology innovation. Furthermore, Delaware, being such a small state, did not benefit from military production investment in the way many Sun Belt states did.
According to some, Delaware's unique laws and subsequent appeal to corporations is undermining other states
Manufacturing, as in many other northeastern states, has declined in recent years, and Delaware also lacks the ability to attract large numbers of tourists: its climate is not much different to those of other states in the surrounding area, which often have more developed tourism industries, as in the beach towns of New Jersey. While far from being an ugly state, neither does Delaware boast any natural wonders on a par with those that can be found in many other parts of the country: nor does it have any man-made attractions that might draw tourists in the same way Mount Rushmore does to otherwise inoffensive South Dakota.
States often use specific legislation and craft certain laws to make them stand out from the crowd, with the express hope of attracting investment, revenue, visitors and residents. Nevada's gambling legislation, many could and did argue, gave it an unfair advantage with regards to tourism. Likewise, those states now legalising recreational marijuana could be accused of the same charge: Colorado is cultivating a tourism industry solely based around its liberal attitude to the drug. Other, more conservative Rocky Mountain states could be asking themselves how on earth they could compete.
When New York City appeared to be in terminal decline in the late-20th century, plagued by social decay and violence, its neighbour state New Jersey openly courted businesses to hop across the Hudson River. Inter-state competition is nothing new.
Distinct entities
Part of the cause for concern over Delaware promoting its own interests supposedly at the expense of other states is down to a perceived weakening of the idea of states being distinct polities with their own unique interests. This was shown in the recent furore surrounding the US presidential election, where Donald Trump won enough states to win the overall presidency by electoral college votes, but fell over 2.5 million votes behind Hillary Clinton in the popular contest.
Many have railed against the result on the basis that the overall popular vote should matter more than the electoral college tally. But whatever the correct decision on this is, the fact that such a system – where states poll their own residents and return their results as one unified vote – suggests a specific understanding of how the states within the US should be viewed.
of US-based Fortune 500 companies are incorporated in Delaware
companies were registered in Delaware as of 2015
Delaware's flat fee franchise tax
States, according to this system, have their own distinct interests: a majority of Pennsylvanians voted for Donald Trump, supposedly as a result of Pennsylvania's specific interests. But those who would favour the national popular vote as the decider of presidential outcomes have a different – and indeed, increasingly popular – view of how states operate. US states, in this view, are not distinct polities with their own discernable interests – rather, they are simply administrative districts of the federal government.
This latter view, of course, would condemn Delaware's enticing of corporations away from other states as unjust or at the very least unfair. On the other hand, the former view – that states have their own interests and they are expected to exert them – would hold Delaware's policies as being entirely legitimate. However, it is important to note there are certain areas in which states already cannot compete, such as those where it is specifically banned by the US Constitution. This includes, for instance, the levying of tariffs on other states or efforts to disrupt commerce flowing through one state to another.
Place in history
Any union of states often faces such trouble. The EU is overcome with intrastate rivalry on issues from different tax regimes to attitudes towards trade with China. Northern EU states are, typically, more open to Chinese trade, while southern states, such as Italy and Portugal – which still hope to preserve their struggling textile industries – generally take a harder stance. The EU often tries to standardise regulations across states, but this is usually met with much resentment.
The EU also specifically restricts the ability of states to lend public assistance to private industry – for instance, 'bailing out' banks is now proscribed, with banks in financial folly needing to be 'bailed in' – much to the chagrin of Italy.
Delaware is a small state with little in the way of natural assets, hubs of innovation or other drivers of economic growth. To this end, it is using its unique history to carve out an economic model that allows it to ensure revenue, jobs and growth. This may be at the expense of other states, but that is not uncommon within the US.
Delaware is making the most of what it has. The US states are, at least for now, distinct entities and all pursue certain economic policies at the expense of others. Delaware is just doing what states in the country have always done, and indeed are assumed to continue to do, according to the design of the United States of America.


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John Bunyan, the author of Pilgrims Progress had his dying words recorded while on his death bed. Here are his final thoughts on affliction:
Nothing can render affliction so insupportable as the load of sin: would you, therefore, be fitted for afflictions, be sure to get the burden of your sins laid aside, and then what afflictions soever you may meet with will be very easy to you. If thou canst hear and bear the rod of affliction which God shall lay upon thee, remember this lesson—thou art beaten that thou mayest be better. The Lord useth his flail of tribulation to separate the chaff from the wheat. The school of the cross is the school of light; it discovers the world's vanity, baseness, and wickedness, and lets us see more of God's mind. Out of dark affliction comes a spiritual light. In times of affliction we commonly meet with the sweetest experiences of the love of God. Did we heartily renounce the pleasures of this world, we should be very little troubled for our afflictions; that which renders an afflicted state so insupportable to many is because they are too much addicted to the pleasures of this life, and so cannot endure that which makes a separation between them.
Darren Carlson is the Founder and President of Training Leaders International. As President, Darren oversees the general direction of the ministry and serves as an advocate for pastors with little access to formal training and thoughtful cross-cultural theological engagement. You can connect with him on Facebook and Twitter.


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Dads, Would You Drive a Lincoln MKT?
Here's a new one for the blog. I'm asking all the dads out there if they would be caught dead driving the new Lincoln crossover called the MKT. I'm testing it this week for a full review on Cars.com and would like to include real-world dad feedback on what they think of the looks.I don't want to influence anyone, but me, I like it.
Now it isn't cheap, it starts at $44,200 but a new Lincoln Navigator SUV starts well over $50,000.
My tester also has a turbocharged V-6 engine which is pretty fast. For more pictures check out this post but I want to hear gut reactions in the comments below. Feel free to blog about it yourself too or tweet it, facebook it etc. Just let me know where I can see the feedback. Thanks.


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Volunteer with the Alliance
Alliance to End Homelessness: Call for Board Members (NEW)
The Alliance to End Homelessness Ottawa is seeking to fill several volunteer Board of Directors positions to begin in September 2017. The Alliance is actively seeking Board Members with skills in finance/accounting, fundraising, legal, communications, public relations, HR and non-profit management. Join a dynamic team of Alliance members and bring your experience to work in partnership to inspire action, generate knowledge and inform a community wide effort to achieve an end to homelessness in Ottawa.
For more information and to apply, visit the links below. Application Deadline: July 21st, 2017 – 5pm EST
Call for Nominations Board of Directors
Call for Nominations Board of Directors – Treasurer
Alliance to End Homelessness: Call for Volunteers (NEW)
The Alliance to End Homelessness Ottawa is currently seeking dedicated volunteers who can help to support the administration of a small but mighty team. We are looking for volunteers to fill two positions in website development and accounting/financing respectively. This opportunity will allow you to network, make new contacts, broaden your skills and experience – while giving back to the community.
For more information and to apply, visit the links below. Application Deadline: July 21st, 2017 – 5pm EST
Accounting Professional / Bookkeeper (Volunteer)
Web Design Coordinator (Volunteer)
Alliance to End Homelessness: Call for Committee Members / Volunteers
You're invited! Volunteers are welcome to apply to serve on various Alliance to End Homelessness (Alliance) Ottawa Standing Committees. Membership on a committee enables you to use your expertise and experience to help guide Alliance activities, while also offering the opportunity to network with other Alliance members and supporters.
We are looking for those who have an interest and experience in areas related to the mandates of four committees, as follows:
- Communications, Outreach and Cultivation Committee: The focus of this group is to help in the creation and delivery of messages to external audiences. Effective media relations, journalism, social media and design skills are of significant interest.
- Membership Development Committee: The focus of this group is to assist in developing and executing strategies oriented to growing and sustaining our membership.
- Policy and Political Analysis Committee: The focus of this group is to serve as an advisory to the Board in monitoring, scanning and undertaking research on public policy related to housing and solutions to homelessness. The group assists in development of public policy recommendations for the Board's consideration.
- Research Committee: The focus of this group is to connect the work of the Alliance and its member organizations to the broad research community, to advance our shared vision. The committee provides oversight on all of the research projects undertaken and underway, assisting in the transfer of knowledge on the causes of homelessness and on effective interventions. The group monitors local research priorities and facilitates, monitors, and supports high impact research undertaken by the Alliance.
How to Apply: If you are interested in volunteering, please complete the Committee Member Volunteer application form at the link below, to be submitted electronically. Additional information can be obtained by emailing firstname.lastname@example.com


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Don't do numbers? You don't know what you're missing !
Thursday October 2, 2014
Over on his Exploring Internal Communication blog, our Kevin Ruck has published his formula for successful internal communication. He launched it today at the CIPR Inside Internal Communication Conference.
I often hear comms people say " I don't do numbers". Heck, I say it myself. But we can't really get away with that anymore because the people we have to convince of the value of communication usually want to see the numbers - and I don't mean financial. Plus, if as communicators we aren't grounding what we do in research, as Kevin says, we are working blindfold.
As Kevin puts it:
"You cannot begin to measure internal communication unless you conduct research to set measurable communication objectives which then form the basis for assessing impact.
"Research and measurement is the Achilles Heel of internal communication practice. This might be because most practitioners have an arts or social sciences background and so may prefer to work with words and pictures than with numbers. That is certainly the case for myself. However, during the past two years as part of my PhD research at the University of Central Lancashire I have learned how to love numbers and I have been amazed at the insights that can be generated."
Read more and check out the formula.


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This Week in FCPA-Episode 55, the Covfefe Edition
Polsinelli Podcast - Pharmacy Compounding: What's Next in Regulation?
Uncovering Factory Farming - The Effects of Ag Gag Laws
Polsinelli Podcast - Food Safety Modernization Act
Stealth Lawyer: Tama Matsuoka Wong, Forager for Restaurant Daniel
Regulatory Challanges When Bringing a Vehicle to Market in the United States
Chicago SSB Tax May Cause State to Lose Federal Funding, USDA Warns -
According to a warning letter from the U.S. Department of Agriculture (USDA), the sugar-sweetened beverage (SSB) tax that took effect in the Chicago...more
EU to Issue Guidelines on Discriminatory Food Distribution -
European Commission President Jean-Claude Juncker has reportedly indicated the EU will issue guidelines discouraging companies from selling apparently identical...more
Some of the most famous and luxurious brands (Champagne, Bordeaux, Port) around the world are geographical indications (GIs) and bring in substantial revenue for the United States and Europe. According to the European...more
While formal NAFTA renegotiation has not begun, there has been movement by the administration to begin reshaping trade deals with both Mexico and Canada since President Trump announced his plans and sent notice to Congress to...more
Brazilian Meatpacker to Pay $3.2 Billion to Settle Bribery Charges -
The holding company of Brazilian meatpacker JBS SA has reportedly agreed to pay a $3.2billion fine for the company's involvement in a graft and bribery...more
In the last two weeks, 75 Wisconsin dairy farmers were notified by their dairy that it could not accept their milk. The dairy and its farmer suppliers are caught in a U.S.-Canada trade dispute over "ultra-filtered" milk....more
A WTO Panel has issued a mixed ruling in a challenge by China to the EU's modification of its tariff schedule for goods.
Significance of Decision:
This important decision provides new clarity on the...more
On 29 March 2017, the UK will formally trigger the Article 50 process to begin the negotiations for Brexit. If there is a 'hard Brexit' in 2019, the UK would trade with the EU – along with most of the rest of the world – on...more
The stench of corruption continues to bedevil Brazil, even as the clean-up initiated with Operation Car Wash is ongoing. This time, allegations of bribery and corruption have reached one of Brazil's most prestigious exports,...more
President Trump's plans to renegotiate the North American Free Trade Agreement (NAFTA) give rise to a number of questions about the future of trade between the United States, Mexico and Canada.
While such a move might...more
International developments on modern slavery -
US Customs has seized four shipments seeking to enter the US this year. This follows developments early in 2016 when President Obama signed the Trade Facilitation and Trade...more
The Grain and Feed Trade Association ("Gafta") recently published a new edition of its Arbitration Rules No. 125 (the "Gafta Arbitration Rules"), effective for contracts dated from 1 September 2016. The previous Gafta...more
On May 12, 2016, the European Parliament renewed its call for mandatory country-of-origin labeling ("COOL") for meat and dairy products not currently subject to such marking rules. The reasoning behind requiring additional...more
Monsanto's Indian joint venture has come under fire anew for allegedly anti-competitive behavior.
India's Competition Commission opened investigations this week into allegations that Monsanto and its partner Mahyco...more
In Budget 2016: Growing the Middle Class, the Government of Canada announced its intention to eliminate tariffs on food manufacturing ingredients, such as those used in the agri-food processing industry, as part of its plan...more
Today, following a protracted legal battle at the WTO, USDA issued a final rule removing mandatory Country of Origin Labeling (COOL) requirements for muscle cut and ground beef and pork.
Beginning in 2008, Canada and...more
USTR Issues Report on China's Implementation of WTO Agreements -
The office of the United States Trade Representative (USTR) recently issued an annual report on China's implementation of its obligations under the World...more
Since the early part of this century, the fast-paced development of Alberta's oil sands and the push for more pipelines across the country have driven Canada's economic fortunes. Indeed, the Toronto Stock Exchange is one of...more
On November 27, 2015, the Food and Drug Administration (FDA) published the final rule on Foreign Supplier Verification Programs (FSVP) for Importers of Food for Humans and Animals under the FDA Food Safety Modernization Act...more
During January 13-15, 2016, the U.S. International Trade Commission ("ITC") held hearings concerning the likely impact of the Trans-Pacific Partnership Agreement ("TPP") on the U.S. economy. Witnesses from a variety of...more
With the inclusion of an electronic bills of lading clause in the latest iteration of the NYPE form, as well as the International Group of P&I Clubs' approval of 3 electronic trading systems, we discuss some of the possible...more
On December 19, the World Trade Organization (WTO) concluded its 10th Ministerial Conference in Nairobi, Kenya. The Ministerial Conference, which typically is held every two years, is a meeting of the decision-making body of...more
Attached is the first half of the December blog post, which covers the collateral damage caused by US Antidumping Orders on downstream US production by the numerous antidumping orders against raw material inputs from China,...more
The WTO Reaches 500 Requests for Dispute Settlement -
The World Trade Organization (WTO) reached a milestone on November 10 when Pakistan filed the 500th request for trade consultation since the organization's inception...more
The UK Competition and Markets Authority (CMA) regularly publishes compliance materials aimed at educating the business community in the UK. These are well worth a read by anyone involved in competition law compliance in the...more
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Irving was ranked as one of the best cities for IT Young Professionals nationally.
12. Irving, TX
Though it's a quick drive from major cities like Dallas and Fort Worth, Irving holds its own in both business and entertainment.
The city is home to the global headquarters of five Fortune 500 companies. And with Microsoft on its short list of top employers, there's a wealth of high-yield IT opportunities available. Irving's bustling business district, historic sites and local attractions draw a diverse, lively crowd.
If you move to Irving, you'll find art, adventure and entrepreneurial spirit — all on a global scale.
Analysts pulled statistics for available Information Technology jobs from Indeed.com, comparative salary average for all occupations from the Bureau of Labor Statistics, cost of living from BestPlaces.net, and average age from the U.S. Census Bureau to determine the best cities for IT young professionals.
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Advisors could be doing more to turn highly satisfied customers into active referrals, according to an investor survey released Wednesday.
The results of the 2010 Economics of Loyalty survey found that despite the difficult investment environment of the past two years, most investors were satisfied with their advisors and planned to continue working with them. But many of those investors did not spread the word about those services.
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Microchip – Microsoft – of course none other than Bill Gates and gang – in the name of humanity of course. This will be the final straw – women will no longer have control of their fertility. The government will insist that women keep this chip in until the government is ready for you to conceive and bear children.
Is this what our daughter's will be faced with? A constant synthetic hormone drip and when she complains to the doctor he will give the "Take Two Valium and Go Home Honey! Syndrome" speech telling her it is all in her head.
Is the the new birth control movement – taking control of us?
That is the question we need to be asking.
Bill Gates Foundation Announces Implantable Remote-Controlled Contraceptive Microchip That Can Last Up To 16 Years
Collective Evolution
July 12, 2014
Bill Gates, one of the world's most notable (or notorious) billionaires is at it again, announcing a remote controlled implantable birth control chip that could last up to 16 years.
The idea sprouted after a visit Bill made to the Massachusetts Institute of Technology (MIT) two years prior, where he asked professor Robert Langer if there was any way to turn birth control on and off via remote control. This would spare women the trouble of visiting the clinic to have contraceptive implants removed when they wanted to become pregnant.
Langer connected the Gate's Foundation with MicroCHIPS, a Massachusetts firm licensed to use a controlled-release microchip technology. Since then, the partnership has been busy developing the technology which could see a release as early as 2018, with safety tests starting this year.
MIT stated the implant would have to be encrypted to protect wireless data flow and keep it secure. The chip's size is 20mm x 20mm x 7mm and reservoirs of the hormone are stored on a 1.5cm-wide microchip within the device.
The birth control microchip would hold nearly two decades worth of a hormone commonly used in contraceptives and dispense 30 micrograms a day, according to a report from the MIT Technology Review. The implant's daily dose works by a small electric charge that melts an ultra-thin seal around the hormone.The birth control microchip can be implanted in the buttocks, upper arm or abdomen.