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We developed an engineered three-dimensional (3-D) tumor xenograft model of non-small cell lung cancer (NSCLC) in nude mice, and used this model to evaluate a dual-activity inhibitor of lysophosphatidic acid (LPA) biosynthesis and receptor activation.
First, BrP-LPA, a pan-antagonist for four LPA receptors and inhibitor of the lyosphospholipase D activity of autotaxin, was examined for inhibition of cell migration and cell invasion by human NSCLC A549 cells. Second, A549 cells were encapsulated in 3-D in three semi-synthetic ECMs based on chemically-modified glycosaminoglycans, and injected subcutaneously in nude mice. Tumor volume and vascularity were deteremined as a function of sECM composition. Third, engineered NSCLC xenografts were formed from A549 cells in either Extracel-HP or Matrigel, and mice were treated with four intraperitoneal injections of 3 mg/kg of BrP-LPA.
First, BrP-LPA inhibited cell migration and invasiveness of A549 cells in vitro. Second, tumor growth and microvessel formation for 3-D encapsulated A549 cells in vivo in nude mice increased in the order: buffer only < Extracel < Extracel-HP < Extracel-HP containing growth factors plus laminin. Third, tumor volumes increased rapidly in both Matrigel and Extracel-HP encapsulated A549 cells, and tumor growth was markedly inhibited by BrP-LPA treatment. Finally, tumor vascularization was dramatically reduced in the A549 tumors treated with BrP-LPA.
Engineered A549 lung tumors can be created by 3-D encapsulation in an ECM substitute with user controlled composition. The engineered tumors regress and lose vascularity in response to a dual activity inhibitor of the LPA signaling pathway.
Lung cancer is the leading cause of cancer death in the United States,1, 2 and among lung cancer patients more than 80% have non-small cell lung cancer (NSCLC). Surgical resection remains the mainstay of therapy for early-stage non-small cell lung cancer and provides the best opportunity for cure.3 However, many of the patients who present with lung tumors are poor surgical candidates due to limited pulmonary function and severe medical co-morbidities.4 Therefore, chemotherapy is the primary first-line treatment option for the 70–80% of patients who present with locally advanced or metastatic disease.5 Although many new anti-angiogenic and anti-metastatic treatements are in preclinical development, a predictive and reproducible animal model of lung cancer that could reliably translate preclinical results to efficacy in human patients remains an unmet need. There is general agreement that tumor xenograft models are useful, but are in need of improvement.6–8
Human lung cancer cells do not grow readily in athymic mice, even when a large number of cells (> 1 × 107 cells per mouse)9, 10 and/or immunosuppressive agents are used to obtain tumors.10 Delivery of tumor cells in Matrigel, a three-dimensional (3-D) extracellular matrix (ECM) extracted from murine sarcoma tissue, overcomes some of these shortcomings by providing a growth-enhancing environment that mimics the tumor microenvironment.11 An alternative approach was the use of Extracel, an in situ-injectable mimic of the ECM developed for 3-D cell culture and for tissue engineering, to produce cell-seeded semi-synthetic ECMs (sECMs) suitable for drug evaluation.12, 13 Indeed, this approach of "tumor engineering" succeeded in (a) increasing the incidence of cancer formation and reducing variability in tumor size, (b) enhancing growth of organ-specific cancers with good tumor-tissue integration, (c) improving vascularization and reducing necrosis in the tumor, (d) reducing cancer seeding on adjacent tissues or organs, and (e) improving the overall health of the animals.14 Low-take ovarian and colon cancer cell lines, breast cancer cells, and metastatic pancreatic cancer cells formed vascularized, localized, orthtopic tumors in nude mice.14, 15 Recently, this tumor engineering model has been validated for evaluation of new anti-cancer compounds that modify signal transduction pathways essential for tumor cell migration and proliferation.16
The in situ crosslinkable sECM Extracel is fully chemically defined and non-immunogenic, and its composition, compliance, and even rate of crosslinking can be customized for specific cell types for in vitro and in vivo applications.12 The critical importance of angiogenesis in growth and metastasis of lung cancers has led to investigation of an increasing number of antiangiogenesis agents for all types of pulmonary malignancies.17 This angiogenesis is mediated by factors such as vascular endothelial growth factor (VEGF).18 Immobilization of a thiol-modified heparin derivative in the sECM provided a component that mimicked the heparan sulfate proteoglycans (HSPGs) of native ECMs.19 This HSPG-mimetic sECM allowed spatiotemporal control of the delivery of single or dual growth factors, including bFGF, VEGF, angiopoetin-1, and KGF,20 and elicited a formation of mature vasculature in vivo.21–23 Growth-factor loaded Extracel-HP has also been shown to recruit endogenous mesenchymal stem cells in vitro.24
Lysophosphatidic acid (LPA) is a bioactive lipid that promotes cancer cell proliferation, migration and survival through activation of cell surface G protein-coupled receptors.25–27 In particular, the ascites of ovarian cancers is rich in LPA and has been implicated in growth and invasion of ovarian cancer.28 Recently, LPA was found to stimulate hypoxia-inducible factor-1-independent VEGF expression to promote tumor angiogenesis through activation of the c-Myc and Sp-1 transcription factors.29 Moreover, LPA reduced the cellular abundance of the tumor suppressor p53 in A549 lung carcinoma cells, which express endogenous LPA receptors.30
Inhibiting the production of LPA is also a relevant therapeutic target.31, 32 The lysophospholipase D (lysoPLD) activity of the tumor-associated protein autotaxin (ATX) converts lysophosphatidylcholine (LPC) to LPA.33, 34 ATX, one of the forty most upregulated genes in invasive cancers, is implicated in cell motility and tumor invasion, metastasis, and neovascularization35, 36 Thus, simultaneously abrogating signaling through the GPCRs and attenuating LPA production by ATX suggested dual activity metabolically-stabilized LPA analogs,37, 38 such as those found to reduce breast cancer in orthotopic xenograft models,16 would also have potential as therapeutic agents for treatment of lung cancer.
We describe herein the optimization of a new lung cancer xenograft model using human A549 NSCLC cells encapsulated in a 3-D sECM. First, we modified the composition of the modular sECM by addition of growth factors and laminin peptides to improve tumor growth characteristics. Next, we compared A549 tumors produced in the optimized Extracel-HP formulation to those generated in Matrigel to evaluate the ability of BrP-LPA, a dual activity LPA receptor antagonist and autotaxin inhibitor (Figure 1, Table 1), to induce tumor regression and reduce tumor vascularization. The sECM model demonstrated that a biologically relevant context for A549 cells could be customized, with full user control over composition of the matrix, to evaluate new therapeutic agents for lung cancer in vivo.
The injectable sECMs tested included Extracel-XX (a 2% w/v hydrogel) and Extracel-HP (Glycosan BioSystems, Salt Lake City, UT). Hydrogels generally formed within 20 min following the mixing of the components according to the manufacturer's instructions. For this study, Extracel-HP hydrogels were formed by adding Heprasil into Gelin-S and PEGDA (v:v:v=1:1:0.5). For hydrogels containing growth factors, VEGF and bFGF were added into the mixture before gelation to give final concentrations of 600 ng/mL VEGF and 600 ng/mL bFGF. For the hydrogel containing the laminin peptide, stock synthetic peptide CGIKVAVGY ("L4") was added to the Extracel-XX or Extracel-HPG prior to adding the crosslinker PEGDA to the thiol-modified macromonomer mixture 39 to give a final concentration of 2 mg/mL.
A549 cell lines were purchased from American Type Culture Collection (ATCC, Rockville, MD). Cells were cultured using the recommended complete medium, F-12K medium supplemented with 10% fetal bovine serum (FBS, Hyclone, Logan, UT), 100 U/mL penicillin (GIBCO), 100 µg/mL streptomycin (GIBCO).
A549 cells were plated in triplicate into six-well plates at a concentration of 3 × 105 cells per well. Approximately 48 h later, the confluent cell layers were carefully scratched using sterile pipette tips. Nonadherent cells and cellular debris were removed by washing with PBS. For the first set of experiments, fresh medium alone (with 0.5% FBS) or medium with 0.5% FBS containing 10 µM or 40 µM of BrP-LPA16, 37 was added into the wounded monolayers. For the second set of experiments, medium was supplemented with 1 µM 20:0 LPA (Echelon Biosciences, Inc., Salt Lake City) or with 1 µM 20:0 LPA plus 10 µM or 40 µM of BrP-LPA. Cells were observed under the microscope and digitally photographed at different times. Inhibition of migration was assessed when the wound in the control was closed and quantified by using ImageJ.40
The invasive behavior of cells was determined in vitro using 24-well transwell inserts fitted with 8 µm pore size PET membranes, which were coated with 0.368 mg/mL Matrigel.41 A suspension of cells (100 µL of 5 × 104 cells/mL) in serum-free medium with or without 10 µM BrP-LPA was added to triplicate inserts, and 600 µL medium supplemented with serum was used as the chemoattractant in the lower chamber. After 24 h, the cells that did not invade through the pores were removed, and cells that passed through the filter on the underside of the membrane were stained with the Diff-Quick Staining Set (IMEB Inc., San Marcos, California) and counted. Ten fields of cells were counted for each well, and the mean number of cells per field was calculated. Each experiment was performed in triplicate and repeated at least twice.
Female 4–6 week old nu/nu mice (Charles River Laboratories, Wilmington, MA) were anesthetized by intraperitoneal injection of ketamine (80 mg/kg) and xylazine (10 mg/kg) as approved by the University of Utah Institutional Animal Care and Use Committee (IACUC). Before inoculation, A549 cells were trypsinized and resuspended in different Extracel compositions (Glycosan BioSystems, Inc. Salt Lake City, UT) with a final concentration of 5 × 107 cells/mL, and the resulting suspension was mixed gently by vortexing. The following ECM compositions were examined with six mice per group: Extracel-XX, Extracel-HP alone, and Extracel-HP containing 600 ng/mL bFGF and 600 ng/mL VEGF as well as 2 mg/mL of the L4 peptide. For the negative controls, cells were injected in PBS only. For each composition, a 200 µL aliquot of the cell suspension was injected subcutaneously into two injection sides on the dorsum of each mouse.
Treatment with BrP-LPA, synthesized and provided by Dr. Honglu Zhang (U of Utah), was performed as previously described 16 with modifications. The mice were randomly divided into two treatment groups and two control groups (six mice per group). In the first controlled experiment, a suspension of A549 cells in Extracel-HP with added L-4 (2 mg/mL) but without growth factors (5 × 107 cells/mL) was prepared, and prior to gelation, a 200-µL aliquot was injected subcutaneously into the dorsum of each of the twelve mice in the control and treatment groups. In the second controlled experiment, a suspension of A549 cells was prepared in Matrigel (5 × 107 cells/mL) at 4 °C, and a 200 µL aliquot was injected subcutaneously into the dorsum of each of the twelve mice in the control and treatment groups. For all groups, tumors were allowed to form for 2.5 weeks. Then, each treatment group received i.p. injections of BrP-LPA (3 mg/kg) twice per week for 2 weeks; the control groups were injected i.p. with physiological saline.
The tumor sizes were measured with digital calipers and calculated as follows: tumor size (mm3) = [width (mm)]2 × [length (mm)]/2. The anti-tumor effects of the treatment were evaluated in terms of the lowest T/C values (%), where T is the relative mean tumor size of the treatment group, and C is the relative mean tumor size of the control group at any given time. The animals' body weights were measured at the time of tumor measurement to monitor for any drug toxicity. Mice were sacrificed after 7 weeks, and the tumor tissues were removed for histology and processed for H&E staining and immunohistochemistry using an anti-CD31 antibody as previously described.16
Data from in vitro and in vivo experiments were processed to express as the mean ± SD of at least triplicate determinations. Statistical comparisons were performed by Student's t test, and differences were considered significant at p < 0.05.
The effects of BrP-LPA without or with LPA stimulation on the cell migration of A549 lung cancer cells were tested using a scratch wound assay (Figure 2). A549 lung carcinoma cells express endogenous LPA receptors LPA1–3, 30 and LPA1 is the most important GPCR mediating cell migration of normal and neoplastic cells.42 In the first set of experiments, after treatment with different concentrations of BrP-LPA, cells were allowed to migrate into the denuded area for 0, 8 and 16 h. By 16 h, untreated control cells completely filled the scratched area, while the migration of A549 cells was significantly decreased (p < 0.05) by 40 µM BrP-LPA when compared to untreated cells. In a second set of experiments, cell migration was stimulation with 1 µM arachidoyl (20:0) LPA, and the ability of BrP-LPA to antagonize this activation was examined. Importantly, even under these stringent conditions, 40 µM BrP-LPA significantly decrease cell migration compared to the LPA-stimulated cells. Inhibition of cell migration at both time points suggests that these effects are not due to inhibition cell of proliferation.
To examine the ability of BrP-LPA to inhibit the invasiveness of A549 cells, an in vitro invasion assay using a modified Boyden chamber was employed. A549 lung cancer cells showed prominent invasion through Matrigel-coated transwell membranes (Figure 3a). Treatment with BrP-LPA inhibited the invasion (p < 0.05) for A549 cells (Figure 3b), suggesting that BrP-LPA has the potential to reduce the metastatic potential of lung cancer cells in vivo.
Subcutaneous injection of A549 cells suspended in PBS only, Extracel-XX, Extracel-HP, and Extracel-HP plus growth factors and L4 into nu/nu mice resulted in tumor growth at all sites of injection (Figure 4). As anticipated, the slowest rate of tumor growth occurred in the buffer-only injected cells, while cells in the 2% w/w Extracel-XX, in analogy to the previous tumor engineering studies with breast, ovarian, and colon cancer, generated significantly larger tumors 769 ± 251 mm3 over the 7-week time course. Even without added GFs, Extracel-HP alone provided better tumor growth environment than Extracel-XX, reaching 949 ± 148 mm3. This demonstrates that the addition of the HSPG-mimetic crosslinkable heparin component alone could improve tumor growth. The addition of the VEGF + bFGF combination, and the covalent addition of the IKVAV-containing laminin peptide appeared to provide only a modest improvement (1012 ± 322 mm3) over the simpler Extracel-HP.
H&E staining allowed visualization of the cellular organization within the tumor mass, and revealed that the tumors were mainly composed of carcinoma cells in the untreated groups with blood vessels. Immunohistochemistry using anti-CD31 antibodies identified the microvascular pattern within the NSCLC tumors (Figure 5a). Further calculation of the microvessels density (MVD) was performed when stained CD31 immunohistochemical tests were obtained. The results indicated that sECMs with immobilized heparin modulated GF release and promoted the development of functional microvessel network (Figure 5b).
Two hypotheses were tested simultaneously with the in vivo models. First, we asked whether Extracel-HP could be used in place of the commonly-used Engelbreth-Holm-Swarm mouse sarcoma-derived Matrigel for 3-D encapsulation for rapid growth of vascularized tumor tissue. The analytical data accompanying Matrigel indicate that the predominant growth factors present include TGF-β, EGF, IGF, bFGF, and PDGF. Second, we tested whether the engineered tumors in each ECM substitute would be susceptible to treatment with BrP-LPA, which had been shown to cause breast tumor regression in an engineered orthotopic xenograft model.16
Subcutaneous injection of A549 cells suspended in either Extracel-HP (Figure 6) or Matrigel (Figure 7) formed tumors in vivo, which in the untreated control group after 7 weeks grew to 864 ± 211 mm3 in Extracel-HP and 1058 ± 427 mm3 in Matrigel. It is not surprising that A549 cells suspended in Extracel-HP + L4 (Figure 6a) had a slightly lower growth rate than cells encapsulated in Matrigel (Figure 7a), since the tumor-derived Matrigel has the full spectrum of sarcoma-derived growth factors and other basement membrane components which provide cancer cells with a naturally favorable microenvironment. What is remarkable is how small the difference is. With only a minimal laminin peptide, without growth factors, and without a myriad of tumor ECM factors, a simple crosslinked hydrogel composed of a network of chemically-modified HA, gelatin, and heparin recapitulated the majority of the cues provided by the tumor microenvironment. Moreover, Extracel was readily handled at room temperature rather than at 4 °C.
After 2 weeks of tumor growth, mice in the treatment groups received intraperitoneal injections of BrP-LPA (3 mg/kg), twice per week for 2 weeks. The dose was selected on the basis of the previous dose of this pure anti diastereoisomer of BrP-LPA that was found to be effective in reducting tumor volume and vascularity in an orthotopic breast cancer model.16 In both the Extracel (Figure 6a) and Matrigel (Figure 7a) groups, a significant reduction of tumor size was observed by the end of the first week of treatment when compared to the respective control groups. During treatment, estimated tumor mass did not exceed 10% of body weight, and the exposure to BrP-LPA for 7 weeks did not reduce the body weight significantly (data not shown), indicating that the compound was well tolerated with minimal off-target toxicity. We had previously observed a similar lack of general toxicity in a 10 mg/kg dose of the mixed diastereoisomers of BrP-LPA.16
After completion of the 2-week treatment course, tumor sizes in both treatment groups were significantly decreased (Figure 6a, Figure 7a). More importantly, tumors continued to regress for an additional three weeks following the final BrP-LPA injection in both the Matrigel and Extracel-HP matrices. The figures show statistically significant differences at each time point, from midway through the drug doses through to the end of the experiment.
At 7 weeks, animals were sacrificed, and the tumors were surgically removed and prepared for histology analysis. The tumor samples in the BrP-LPA treatment groups were significantly smaller than the tumor tissues in the control group (Figure 6b, Figure 7b). H&E staining revealed an irregular arrangement of tumor cells and an increased number of blood vessels (Figure 6c, Figure 7c) in the untreated controls compared with in the BrP-LPA treated group (Figure 6d, Figure 7d). An endothelial layer covering tumor vasculature was observed using immunohistochemical staining with anti-CD31 antibody (Figure 6e, Figure 7e), which was reduced in both treatment groups (Figure 6f, Figure 7f). Finally, the quantification in six different fields of three separate slides for each treatment group (Figure 6g, Figure 7g) showed highly significant reduction of angiogenesis (p < 0.05).
We tested two hypotheses using engineered NSCLC tumor xenografts. First, we asked whether a simple, modular sECM such as Extracel could be used in place of the mouse sarcoma-derived Matrigel to support rapid growth of vascularized tumors. Second, we examined how engineered tumors in each ECM substitute would respond to systemic treatment with BrP-LPA, an LPA antagonist/ATX inhibitor that had been shown to cause breast tumor regression in an engineered orthotopic xenograft model.16 These two issues are discussed separately below.
Current animal models of lung cancer have low rates of tumor growth and metastasis.43 Growing human lung cancer cells in athymic mice has been problematic,9, 10 even when immunosuppressive agents and a high density of tumor cells are used to obtain tumors.10 In the basement membrane, metastatic lung tumor cells attach preferentially to laminin.44, 45 Laminin stimulates tumor cell adhesion,46 collagenase IV production,47 cell motility,48, 49 and the formation of metastasis.45 One potential opportunity to improve xenograft quality would thus be to include laminin or a laminin derived peptide to increase the tumorigenicity of 3-D encapsulated lung cancer cells in vivo.
Cell-matrix interactions in 3-D are an essential part of the microenvironment of all cells, including tumor cells 50. The tumor-derived ECM product Matrigel has seen widespread use in distinguishing gene expression and phenotypic differences in cells growth in 3-D51 modeling tissue-specific signaling and organ function in 3-D52, and in modeling glandular epithelial cancers in three-dimensional cultures.53 The use of Matrigel as a 3-D cell delivery system rich in tumor-derived growth factors greatly increases the incidence of cancer formation in vivo.54–56
Despite these advantages, there are procedural disadvantages in the use of Matrigel. For example, the syringe and needle need to be pre-cooled at −80 °C, and all procedures -- from re-suspending cells to preparing the cells for injection -- need to be carried out at 4 °C in a very short time to avoid premature gelation and thus clogging of the needle. These problems are exacerbated during orthotopic injections in surgical models, resulting in increased experimental variability and failed injections. In addition, batch-to-batch variability and lack of user control of the composition of the 3-D matrix further complicate the use of Matrigel. The sECM Extracel addresses many of these drawbacks, offering a room-temperature-injectable 3-D hydrogel vehicle for cell delivery.12, 14 Moreover, in the absence of GFs, the pro-angiogenic effects of the oligosaccharide degradation products of HA have been implicated in the growth of non-necrotic, vascularized tissues from normal13 and tumor-derived cells.14
In order to identify a sECM based on Extracel that would be optimal for NSCLC cells, we investigated the encapsulation of A549 cells in three different Extracel compositions. Since epithelial cells on stiffer substrates have higher moduli and exhibit a more stretched and organized actin cytoskeleton than those on softer substrates,57 we examined the 2% (w/v) hydrogel Extracel-XX, which is stiffer than the 1% (w/v) hydrogel Extracel-X. We also tested Extracel-HP, a sECM that contains an immobilized derivative of heparin, thereby mimicking an HSPG-like microenvironment for presentation and sequestration of basic growth factors (GFs). Finally, we noted that metastatic tumor cells attach preferentially to laminin, the predominant glycoprotein in basement membranes.44, 45 Laminin stimulates tumor cell adhesion, collagenase IV production, cell motility, and the formation of metastasis. The final composition tested was a modification of Extracel-HP containing a covalently-linked IKVAV peptide58 plus VEGF and bFGF growth factors. Surprisingly, the addition of the growth factors and the laminin peptide only showed a modest improvement over just Extracel-HP itself in terms of neovascularization and microvessel formation in the engineered lung cancer xenograft tumors.
LPA GPCRs and ATX present two promising, druggable, yet under-exploited targets for cancer therapy.30, 31, 59 ATX, a potent motogen in metastatic cancers 35 produces a continuous output of LPA,33, 34 potentially abrogating the action of an LPA antagonist. By blocking ATX, the autocrine/paracrine loop that involves the ATX-mediated production of LPA is reduced.32, 59 Although ATX is product feedback inhibited,60 using LPA to inhibit ATX would be counterproductive. Thus, analogues of LPA that retained ATX inhibitory activity yet did not activate LPA GPCRs are needed. BrP-LPA is a potent pan-LPA GPCR antagonist and ATX inhibitor,16 inhibits cell migration, invasion, and proliferation, and thus has clear therapeutic potential.61 In contrast, analogues of cyclophosphatidic acid (ccPA) were selective inhibitors of ATX but lacked agonist activity for LPA1,2,3.61 These ccPA analogues inhibited cancer cell invasion in vitro and suppressed metastasis of melanoma cells in vivo. Reduction of melanoma cell migration in vitro was also demonstrated for several small-molecule ATX inhibitors.62 However, ATX inhibition alone is insufficient, since it is necessary to suppress receptor activation by endogenous LPA as well as reduce LPA production production for maximal therapeutic efficacy.
We have described an useful new engineered lung cancer xenograft model using human A549 NSCLC cells encapsulated in Extracel, a 3-D crosslinked network of chemically-modified gelatin and glycosaminoglycans. The addition of the growth factors VEGF and bFGF, and the addition of a laminin peptide only modestly improved tumor growth. Growth of A549 NSCLC tumor xenografts in Extracel-HP in vivo were compared with NSCLC xenografts in Matrigel, and the models were used to evaluate the ability of BrP-LPA, a dual activity LPA receptor antagonist and autotaxin inhibitor, to induce tumor regression and reduce tumor vascularization. The sECM model demonstrated that Extracel-HP provides a useful new material for A549 xenografts, and allows for complete experimental control over composition of the matrix during the in vivo evaluation of new therapeutic agents for the treatment of lung cancer.
Grant support: Utah Centers of Excellence Program; NIH grant NS29632.
Disclosure of Potential Conflicts of Interest. G.D.P holds equity in Glycosan BioSystems, is an advisor to RxBio and Echelon Biosciences, and has a pending patent application on BrP-LPA.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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OK, so I might be a bit biased as The Pretty Things are quite simply my favourite band - ever - but it's so good to have them back on FdM.
I've being telling their manager Mark St. John for the last year or so that 'The Same Sun' from their latest album should have been a single - and finally it's going to be - I love this song, it really is classic Pretty Things, with Phil and Dick in great form (in fact, Dick co-wrote it with Mark) and it's just one of four tracks on this EP - two songs from their last LP and two live tracks from the 60s that have never appeared on vinyl before 9at least, not as far as I know!)
More news soon

subset: commoncrawl


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Framed Typed Letter Signed on personal letterhead
New York: 1945.
1 page, 5.5 x 5 inches, New York, November 20, 1945, in full: "Thank you very much for your letter. I have received others similar to yours and have already written the Rosenwald Foundation expressing my hope that they could grant the $25,000 to the Southern Conference for Human Welfare. I agree with you that the organization is doing fine work." Elegantly matted and framed in decorative silvered wood with a photo portrait of Mrs. Roosevelt. The outer measurements are 11 x 15 inches. Very good condition.
Binding: Unbound
Language: English
Price: $550.00
Item #237143


text: I recently ordered a Shiva / PR15 / Plate Amp and a few other minor goodies from Kyle Richardson at Acoustic Visions and the service level I received was SUPERB! Never have I worked with a person more dedicated to customer satisfaction. Kyle contacted me quickly everytime I had a question and even when I didn't just to see how things were going. Kyle always made sure everything was good and I was happy even after the order shipped and arrived. I received my shipment from him and not even 1 hour later he was in contact with me making sure that my order had arrived and that everything was good to go. He has also been very supportive in answering my questions and he is easy to get a hold of. In my book if you need to get anything that Acoustic Visions sells (Adire audio / Parts express etc.) Call up Kyle and order it through him. You save a little bit of money and better yet you get outstanding customer service which goes a long way in my book. ------------------


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Willing Or Wanting…..What We Can Do!
I was praying with a friend about forgiving someone and said to her, "You don't have to want to forgive them, just be willing to forgive and Heaven will pour out blessings on the situation."
One of the most exciting personal revelations I have received was that FORGIVENESS is a universal law, a power, like the law of gravity in the earth. There are some groups that build their following on simply teaching others to forgive. It does not matter whether you are a Buddhist, Muslim, Atheist or Christian…..if we are willing to forgive…..I mean, to forgive by a decision of our will, God honors that and peace and favor will follow.
Luke 22:42,43 tells us Jesus went to the mount of Olives and prayed, with such intensity that the capillaries burst on His brow and were as great drops of Blood falling to the ground (Re: Kenneth Wuest's New Testament)…..in agony Jesus ask the Father to take away the upcoming things that He must endure. But in verse 44 Jesus declared God's will be done, not His own. Jesus did not want to take the beatings, the mock and abuse, to die for all mankind, but was willing.
In Luke 23:34 Jesus said, "Father, forgive them; for they know not what they do." And, the universal law of forgiveness was set in motion–by the words of His mouth–that we might use the example and do the same. Forgiveness is not just available but must be given by the words of our mouth and the intents of our heart.
John 20:23 Jesus reinforces this with His authority to the disciples to forgive sin or retain sin…..our choice. Even though this works for anyone willing it would be ludicrous not to honor, love, respect, worship and follow Jesus as the King of Kings and Lord of Lords as He paid for this privilege with His precious Blood.
There are so many things we don't want to do, but will be a blessing if we are willing to do them…..how nice to know we have the choice. God is soooooo good!!!
Whoops!!! Had to come back in to say, nothing is an 'always' situation. We do most adamantly need to not only be willing but want to invite Jesus into our lives and make HIM LORD of our very existence. And, once we do that we want to do as JESUS directs because we love, respect and honor HIM.
I am sure there are other areas where 'want' is important, but isn't it a wonderful picture of G OD's grace that many times we just need to be willing.
Pressing in pressing on……
NOAH….Great Bible Story, What About The Movie?????
I heard that the producers of the movie "Noah" said it was not totally based on the Biblical account…..WOW…..I am glad they said that and wish they had called the movie, "The Great Flood" or "Giant Rock Monsters and Wet Rescue" or something other than Noah.
I go to 'Christian' movies to see what the world is seeing…..enjoyment hoped for! The movie not only disappointed me but made me angry as there was so much judgment and legalism in the movie made man called Noah. I found it very sad and grieved me greatly.
Hebrews 11:7 says "God warned Noah and he built the ark out of fear, (and respect) and was declared righteous by faith. 2 Peter 2:5 tells us Noah was a preacher of righteousness…..sounds more like the people ignored Noah rather than fighting to take the ark, as they did in the movie.
In the movie one son, Ham, goes into the world to find a wife before the ark left–finds a girl, helps her escape from captors. As they are running to the ark the girl steps into and is caught in an animal trap. Noah looking for Ham finds them, pulls Ham away leaving the girl to die. Now, that sure looks like a 'preacher of righteousness' doesn't it ? Well, that did not happen in the Bible so it doesn't matter, just part of a truly fictitious story.
The rock giants looked like monsters out a science fiction movie and the whole world looked ugly and dark most of the time. In the Bible Noah takes his wife, three sons and their wives into the ark. In the movie only one son with one wife, who gave birth to twins born, while on the ark…..Noah declares he will kill the babies if they are girls so they cannot bring more 'evil people' into the world. Ugh! What a nail in the coffin of female bigotry.
In the movie Noah does not kill the baby girls but sees (finally) the love of God in them and feels so guilty he goes off by himself and gets drunk. They don't spend any time (good thing, the movie was long enough) on the facts that they had planted grapes and made wine after the flood was over.
There are some awesome points in the Biblical account of Noah….I hope everyone will read the Bible looking for the goodness of God and the mistakes men made…..so that we might not repeat their pattern. Hosea 4:6–we perish for lack of knowledge of God's ways.
Pressing in and pressing on….
GOD Works With Our Declarations….
It has been said "Nothing happens in the Kingdom of GOD (on earth) without a declaration." Well, I have seen and experienced some things I never declared, but the statement is a goooooood one, because:
Therefore, Holy brethren, partakers of a heavenly calling, consider JESUS, the APOSTLE and HIGH
PRIEST of our confession. (Hebrews 3:1)
I read a small book by Derek Prince (Who has written many wonderful books and is now in Heaven with our JESUS, called, DOES YOUR TONGUE NEED HEALING.) Even though I have read and heard teaching on speaking, words, etc. this little book really convicted my heart the truth of confessing the words of JESUS….declaring them out loud….is our way of being junior partner with our Senior Partner, JESUS.
Since JESUS is PRIEST over our confession HE uses our declaration on our behalf. How wonderful to have insight into the ways of our GOD, HIS SON JESUS and the HOLY SPIRIT….one of many ways….declaring the TRUTH. The first to hear what we say is our own ears, then the enemy and our JESUS. Very powerful and anointed plan to change our lives and our world. Check out Romans 10:8-10 and James 3:4-5 for more revelation.
What fun, that we do not see what happens in the Supernatural Realm….but 'things' do happen there….all the time, and we just need to believe that.
Pressing in and Pressing on….


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For those of you who don't already know, Plaster is an electronic music project born in Rome in 2008 and comprised of Gianclaudio Hashem Moniri and Giuseppe Carlini, best known for their works on German label stroboscopic artefacts, Berlin-based Unoiki and Ukraine-based label Kvitnu...
Now the Italian duo find themselves in London, joining forces with Touchin' Bass to weave together a damn fine four track ep which aims to mix a combination of styles from downtempo, dark, brooding beats to more compelling rhythms which have the capacity to make you dance... Plaster's sound is impressively textured with rich eclectic tones. It's simple but effective, showing different emotions, tempos and styles.
Look no further... this EP will draw you in, chew you up and spit you out, but you'll be all the better for it.


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Please confirm that you want to add 2017 Web Design No Coding Basic HTML5 or CSS3- Easy Websites to your Wishlist.
***** BREAKING NEWS CLASS UPDATE**** "in 24 hours over 800 new students have joined!" To say thanks, for a limited time you can get a free closing the deal E-book for just completing this course and all its exams!
Ready to make your income rise monthly as a web designer and Business owner?
Ready to make awesome web sites today without code! Not weeks or months!
Or maybe you just want more free time and flexibility?
Ready to have a real business that can make you money at home.
Ready to have clients sign a 3 year contract that pays you every month!
This Complete Web Design Course will cover all the aspects and tools I use in my day to day operation.
You will learn by doing! I will walk you through by using the same software that I use to build my sites. The same type of websites that have paid me monthly since 2012. All without using any code or learning any hard complicated language!!! If you can click and drag you can build websites! It is really that simple.
In this course we will build fully functioning websites.
Clients have paid me up to $2550.00 or more up front to build a website for them. Then they have signed up to a 3 year contract with my company. That pays more than $400.00 month. So just add that up, this is for one client $1200.00 up front. Plus $400.00 a Month for 36 months = $15,600.00! Not too bad for a Web Site made on free software! All you need is 8 clients to make a great Monthly income.
Also this is charged to the client's credit card. So no chasing down clients waiting for checks to clear! Every month automatic deposits in to your business account.
This is exactly what this course is designed to do. To teach you exactly how to do what my business already has been doing since 2012. No Fluff, No hype, just everything I have done and used to make my extra income.
This Complete Wed Design course will cover how to open, own and operate your new web site business! Without needing thousands of dollars to open a business.
If you truly follow my instructions, build the class websites with me in this course. I know you will be able to pay for this class with your first web client if not by your second – I am so confident you will make it that I am offering a full 30 day return policy.
This is a one-stop-shop for everything you need to open and create a professional website company all from your home.
This fast, effective course takes you easily from no skills to a web site business owner in a matter of days! Not weeks.
You and I will be working together, actually using the Free cloud based software to create websites. I am very excited to help you along on this journey to create a couple websites step by step.
In this lesson I will walk you through the sign up for Free, creating your account. Now with this Free account you will be able to start making websites.
In this Lesson you will start choosing the templates you will use to create your First website.
In this class you and I will be learning all about the Pages Menu and all of its functions. How it easily creates your website pages. From adding pages, rearranging pages, and even how to add SEO so your sites can be displayed correctly on google search.
In this class you will learn how easy it is to change the background of a website. You will learn how to change the background to Video that loops, Pictures, even colors and patterns.
In this exciting class you will learn first hand how to easily add many different elements to your website. From Text, Images, Galleries, Buttons, Strips, Shapes, Videos, Music, Social media, Blogs and so much more.
In this section you will learn how to easily add apps to your website all without code!! You will even add a signup form to a website.
In this section you will learn how to upload images, music, documents, all for your website ready to use. I will teach you how to use the built in editor for your images and how to keep them organized.
In this class I will teach you how to add a blog page to your website. How to set up automatic posting of your blogs. How to use different blog templates and how to edit them all without code. You will be able to add images, video and galleries by the end of this class.
In this class you will learn the Top Menu. I will walk you through all the different menus such as how to save you work, how to preview it and publish your site live. There is over 30 different menus to use, don't worry I will walk you through them all step by step.
A welcoming feedback for this section.
This quiz will cover the basics for the first section of this class.
In this class you will learn how to select a specific template website. You will also learn how to name its domain name.
In this class you will see a preview of a website you will make. It will include background video, call to action, testimonial section, action buttons and much more.
In this class you will learn how to start re-editing a template to suite your needs. I will walk you through each step from deleting items, centering items, adding pre-made strips and much more.
In this class you learn how to change the background color on your site. You will also learn how to add 6 pre-made strips to your website. This will be the 6 different elements of your website.
In this class you will add some style and function. You will learn how to animate your text and how to preview them.
In this class you will learn how to add and use anchors. Allowing you to jump from a certain point to point on your website.
In this class I will teach how to set up a call to action sign up form, all without using code.
In this class you learn how to change pictures, group them and ungroup them. Plus how to easily find Free pictures all within the website editor.
In this class you will learn how to easily connect action buttons, how to edit them such as the color and adding links to them.
In this class I will teach you how to connect social links and email forms. Links like Facebook, Twitter, Instagram, and much more.
In this class you will learn how easy it is to change out colors, titles. Plus how to easily add a menu to your website.
In this class you will learn how to edit your new menu and how to delete unwanted webpages from your website.
Some basic overview to make sure you are remembering what you have learned.
It is time to make a E-commerce website! I will teach you how to add a E-commerce section. How to add products with the price, description and images. All without any code!
In this class I will teach you how to manage all your Items in Collections and Product sections.
In this class you will make a coupon for your items. You will learn how to edit them and all the functions that come with a coupon such as start date, end date and even the coupon code.
In this class I will teach you how to connect your payment method such as credit cards, PayPal, and even off line payments.
In this class I will teach you how to set up your Shipping and Tax rates. This will help you send out your items and help you set up all your tax rates for different regions.
Testing to see if you have been watching. :)
In this class I will teach you the basics that you will need to know to set up your first website business.
In this class I will teach you how to easily start networking and find your new clients. I will give you some great ideas to work with and places to find help in your community
Johnny B. Dillon Jr. is a multi-faceted and prolific Entrepreneur who resides in McAllen, Texas.
Johnny was born at the Naval base on the tropical island of Guam, his passion for the business world began early on.
Throughout his expertise as a business professional, Johnny has successfully ran and owned a multitude of businesses. Including two night clubs, and a successful liquor store in South Texas. This is also where Johnny Created and published for almost 3 years a successful tradesman magazine. He also holds a Trade Mark Patent for America's very first Handyman Directory magazine.
Additionally, he currently still holds his General Contractor license in the state of TEXAS for his custom home building company Sun Coast Development, Johnny is no stranger to the financial side of building he has also learned to help his future clients by becoming a Credit Repair Specialist. That he still owns and operates to this day, Approved Credit Repair.
Knowing no limits Johnny has also helped other entrepreneurs with his natural networking skills. Which has put to use with his website company JMD Marketing & Design since 2012.
Johnny in his younger years has even worked as a Videographer & Editor for various world-renowned TV channels, including Telemundo Ch48 Houston, FOX Ch35 WOFL Orlando, CBS Ch12 WPEC West Palm Beach, and NBC Ch6 WTVJ Miami.
Johnny holds an Associate of Applied Arts in Music & Video Business from The Art Institute of Houston and attended the Film & Video Production program at Full Sail University in Orlando.
As a natural born organizer, Johnny has always led through example and has remained fearless in the face of countless changes and challenges. Currently this will be the first of many Udemy Classes that Johnny will create. He wants to share his knowledge and as many skills possible to the world.


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Home » Retail Survey » Geek Squad Customer Satisfaction Survey
Geek Squad Customer Satisfaction Survey
Geek Squad is collect feedback to improve its services and products. So it has designed customer satisfaction survey as a channel. If you want to leave you comments and opinions, you can take it. Upon completion of this survey, you will join the sweepstakes which offers 3 grand prizes with $5,000 Best Buy gift card. You should read the official rules to make sure you have the eligibility for sweepstakes.
Geek Squad Customer Satisfaction Survey Guide
- Visit Geek Squad customer satisfaction survey page
- Choose the type of service that Geek Squad performed for you
- Enter the service order number which is printed at the top of your receipt to continue the survey, enter the lease enter your 19-digit code
- Rate your overall satisfaction with experience at Geek Squad
- Choose the type of service, computer service and the reason for their service
- Enter the information below for a chance to win a $5,000 shopping spree
About Geek Squad
The Geek Squad is a subsidiary of the Best Buy Company. The company offers various computer-related services and accessories for residential and commercial clients. The Geek Squad provides services in-store, on-site, and over the Internet via remote access, and also provides 24-hour telephone and emergency on-site support.
Reference Links
- Geek Squad Customer Satisfaction Survey Link: www.geeksquadcares.com
- Geek Squad sweepstakes Official Rules: survey.confirmit.com/Sweeps/Official_Sweeps_Rules
- Geek Squad Official Site: www.geeksquad.com
Leave a Reply
Rating 4.69votes
Rated 1
Manager: Alfredo ID # 16910, was not attentive to my request in spite of obvious facts
presented.Problem : Kaspersky Lab antivirus software had been forbidden by Feds to be distributed and I had requested refund for it ( it was renewed 1 month earlier). Bestbuy is one of the software distributors. Supprisingly I was refunded $44 dolars for $55 paid ( used it only for 1 month – should be 55:12=4.58 -> refund should have been $50.42 )
Rated 5
I received an excellent service from Jonathan at Geek squad Rio Hondo, Bayamon P.R.
I give him 10 out of 10. Very professional.
Rated 5
I received an excellent service from Carl and Ali at Geeksqad . They were so patient and concerned about my situation. I have no words to express my gratitude to those young men. You guys are just awesome.. Thank you so much…I would give them 10 out of 10.
Rated 5
Vaughn and Nick set up our home entertainment TV in January and they both returned last week to replace our module that had a defect. Both of these men are true gentlemen and efficient workers. It was a pleasure to work with them. Sam Boyer and Joan Funk Order# 38427650.
Rated 5
Sorry to mention the technician name my comments .
His name was Agent Jason Golladay.
Thank You Jason.
Bella Hopper
Rated 5
I was really impressed by the technician who installed my security system,although the Arlo system is a new product and new in the market. He was so attentive to all my questions and explain it so well. And very polite and courteous. Thank you for sending to install our new home security system.
Bella Hopper
Rated 5
I thought I was assisted thoroughly and competitively in every respect, as well as in a patient and friendly manner. Via support and expertise, of agents' Jon, Rob, and Mike. No questions were left unanswered, and I was thankful for choosing BestBuy for my laptop selection. In addition everyone provided valuable help, information, and other services to help me get started with my new purchase.
Rated 5
Excellent service. Unfortunately there is no simple way to download the customer satisfaction survey to provide feedback.
Rated 5
thanks to geek sqaud, they are awesome and thx to julius for helping and giving me full support on what i needed help on
This past month dealing with geek squad and the people who work have been nothing but disastrous. This is also the same experience I received from one of the supervisors who was rude and made it seem like it was no issue that I had already received four defected phones. All of this is a hassle that I should not have experienced when I only put a claim for a broken phone screen. I will never get the geek squad protection plan again and now do not even want a smart phone. These issues never occurred when I had an iPhone or had sprint as my protection plan provider. Worst service I have ever experienced in my life. Even now when I sent my phone in, I did not get a confirmation. For every single thing I had to call every 3-5 days and wait 30 mins to get people who didn't know what they were doing to fix my issue. I put multiple complaints when I called and I had called about 10-15 times. I would like someone to see the whole file complaint because one woman was the one who helped and did anything to fix the problem.
I want to complement the Geek Squad Supervisor,Toby Nelson at the Corpus Christi, Texas Best Buy Store. Our original HP PC purchase was on Nov. 18, 2016. it was too slow so we returned it and purchased a faster one. It turned out the Geek Squad technician, Bryan discovered it was the modem that was the problem, so he called our provider, Spectrum and they were not able to correct it from the office so we had to set up appt. to replace modem. I called the 800-433-5778 to schedule appt. after new modem was installed but no one showed up. I called Toby "again" & she was most courteous and helpful. She called to see what was going on & found out they did not have me in the system. She scheduled an appt. for me & sent Bryan out to finish the job. I was so relieved because at that point I was unnerved to say the least. I can not say how much I appreciate all the help that both Toby & Bryan gave me. They both were so courteous & helpful. I will surely use them again & recommend them to my friends.
I would like to personally take the opportunity to thank the Valley Stream NY store Geek squad management for their true professionalism. Fawwaaz and Mike the two managers are true professionals and are an asset to the store and their department. They made buying my mercahndise so much easier with their knowledge and experience. I will personally tell my contacts to go to the Valley Stream NY store. Great personnel.
We both like to thank Rene for helping us on the purchase of our 2 laptops for our kids. He was very polite and knowledgeable in making our decision easier. WE would also like to thank Gerald at the Geeksquad department for all his help and knowledge. Great experience
I wanted to complement a Geek Squad Technical Associate! Went to the Conroe, Texas Best Buy/Geek Squad location. 00865-293590197 Service Ticket. Michael was absolutely so much help. Was having a really bad day (2 hostile phone calls) while Michael was assisting me with the computer. He was so helpful and considerate. He also said he wanted me to leave with a smile. I went from mad to glad during my visit and did leave with a positive attitude/smile. He went above and beyond to help me out. Michael really did a fabulous job. His professionalism and positive attitude was very much appreciated and he really does deserve an "atta-boy" for my visit. He was knowledgeable, considerate and it made for a fun visit. Best Geek Squad visit ever! Met his supervisor Rudy to tell him what a great job Michael did and Rudy was awesome as well. The new "air" within the Squad area was very "customer service oriented with a personal flare." Big change from previous visits. Give Rudy an "atta-boy" as well. Very impressed and very pleased with the service from beginning to end. They are both "keepers". It has renewed my opinion of "not-so-great transactions in the past" to "way to go and thanks so much". Please reward Michael on a job well done! I felt like I mattered as a customer and as a person. Thanks to all. I WILL RECOMMEND GEEK SQUAD TO OTHERS! Michael, I hope you get a bonus! If I was not unemployed, I would have left you a great tip. Keep up the great work. Rudy, the direction you are taking with the Geek Squad Techs us working. You should also get a bonus. Thanks and God Bless! Sherri


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Tag Archives: pleads
Iraqi province pleads for US to send in troops to help fight Isis – The Guardian
The Guardian Iraqi province pleads for US to send in troops to help fight IsisThe GuardianLeaders of Iraq's Anbar district put out an urgent plea yesterday for immediate foreign and national intervention to prevent the immediate collapse of the province, … Continue reading
Worker on film about Gregg Allman pleads not guilty over fatal Georgia train accident
ATLANTA (Reuters) – A filmmaker pleaded not guilty on Tuesday to charges stemming from a deadly train wreck in southeast Georgia on the set of a movie about rock singer Gregg Allman, prosecutors said. Reuters: Entertainment News
Bitcoin promoter pleads guilty to unlicensed use of currency
By Joseph Ax NEW YORK (Reuters) – A man who helped to promote bitcoin wants to remain in the business despite pleading guilty Thursday to indirectly helping send more than $ 1 million in the digital currency to users of … Continue reading
Posted in Technology Tagged Bitcoin, Currency, guilty, pleads, promoter, unlicensed Leave a comment
Singer David Cassidy pleads guilty to drunken driving in N.Y
SCHODACK N.Y. (Reuters) – Former TV star and teen idol David Cassidy admitted to driving drunk in upstate New York under a plea deal on Wednesday requiring him to undergo state-approved counseling and to equip his cars with a breath-alcohol … Continue reading
Posted in Entertainment Tagged Cassidy, David, driving, drunken, guilty, pleads, singer Leave a comment
Singer Chris Brown pleads guilty to punching fan, says sorry
WASHINGTON (Reuters) – Grammy-winning singer Chris Brown pleaded guilty on Tuesday to misdemeanor assault and told a court he was sorry for breaking the nose of a fan when the man tried to thrust himself into a picture with the … Continue reading
Posted in Entertainment Tagged brown, Chris, guilty, pleads, punching, says, singer, sorry Leave a comment
Singer Chris Brown pleads guilty to assaulting fan in Washington
WASHINGTON (Reuters) – Grammy-winning R&B singer Chris Brown pleaded guilty in a Washington court on Tuesday to a misdemeanor assault charge stemming from a scuffle with a fan last year. Reuters: Entertainment News
Posted in Entertainment Tagged assaulting, brown, Chris, guilty, pleads, singer, WASHINGTON Leave a comment
R&B singer CeeLo Green pleads no contest to ecstasy charge
LOS ANGELES (Reuters) – Grammy-winning R&B singer and former "The Voice" judge CeeLo Green pleaded no contest on Friday to giving a woman the drug ecstasy in 2012. Reuters: Entertainment News
Posted in Entertainment Tagged CeeLo, charge, contest, Ecstasy, green, pleads, singer Leave a comment
Actor Michael Jace pleads not guilty to killing wife -prosecutors
LOS ANGELES (Reuters) – Actor Michael Jace, who played a conflicted cop in the cable television drama "The Shield," pleaded not guilty in Los Angeles Superior Court on Wednesday to a charge of murdering his wife, prosecutors said. Reuters: Entertainment … Continue reading
Posted in Entertainment Tagged actor, guilty, Jace, Killing, Michael, pleads, Prosecutors, wife Leave a comment
Man pleads not guilty to break-in at Sandra Bullock's home
LOS ANGELES (Reuters) – A man arrested for allegedly breaking into actress Sandra Bullock's Los Angeles home pleaded not guilty on Tuesday to charges of burglary, stalking and possession of a machine gun. Reuters: Entertainment News
Posted in Entertainment Tagged breakin, Bullock's, guilty, home, pleads, Sandra Leave a comment
Iraq pleads for west's help with jihadis
Iraq's foreign minister says Baghdad is not seeking intervention but help with counter-terrorism to confront a threat he says endangers US interests Asia homepage


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Advanced Diploma of Industrial Electronics Engineering
What You Will Gain
Contact us now for full details.
Join the next generation of electronic engineers and technicians and embrace a well paid, intensive yet enjoyable career by embarking on this comprehensive and practical course. It provides a solid overview of the current state of electronics engineering practice and is presented in a practical and useful manner - all theory covered is tied to a practical outcome. Leading electronics engineers present the course over the web using the latest distance learning techniques.
This course is not intended as a substitute for a 4 or 5 year engineering degree, nor is it aimed at an accomplished and experienced professional electronics engineer who is working at the leading edge of technology in these varied fields. It is, however, intended to be the distillation of the key skills and know-how in practical, state-of-the-art electronic engineering. It should also be noted that learning is not only about attending courses; but also involves practical hands-on work with your peers, mentors, suppliers and clients.
The course is composed of 18 modules. These cover the following seven main threads to provide you with maximum practical coverage in the field of industrial electronics engineering:
- Electrical/electronic technology fundamentals
- Supporting technologies and services
- Analog electronics
- Digital electronics
- Electronic communications
- Programming
- Electronic maintenance and troubleshooting
Who Should Attend
- Electrical and Electronics Technicians
- Field Technicians
- Electricians
- Plant Operators
- Instrument and Process Control Technicians
- Project Engineers and Managers
- Design Engineers
- Instrumentation and Design Engineers
- Maintenance Engineers and Supervisors
- Energy Management Consultants
- Automation and Process Engineers
- Design Engineers
- Instrument Fitters and Instrumentation Engineers
- Consulting Engineers
- Production Managers
- Chemical and Mechanical Engineers
Course Structure
The 18 modules will be completed in the following order:
- Basic Electrical Engineering Overview
- Understanding Electrical and Electronic Drawings
- Shielding, EMC/EMI, Noise Reduction and Grounding
- Digital System Fundamentals
- Industrial Data Communication Systems
- Power Electronics and Switch Mode Power Supplies
- Industrial Electronics
- Technical and Specification Writing
- Embedded Microcontrollers
- C++ Programming
- UPS and Battery Power Supplies
- Process Control
- Digital Signal Processing
- Data Acquisition Systems
- Programmable Logic Controllers
- Troubleshooting Industrial Electronics Components and Circuits
- Printed Circuit Board Design
- Industrial Wireless
**A note regarding recognition of this course in the Australian education system: The EIT is the owner of this course. The course is officially accredited within the Australian Qualifications Framework by the Training Accreditation Council, and is approved by the Australian Skills Quality Authority (ASQA) for delivery by the EIT in all Australian states. The EIT delivers this course to students worldwide.
Click here to make an enquiry
In Company Online Training Solutions
Special class groups can be arranged on request to match your own schedule. If you have a large number of staff who should complete one of our programs, read more about our In Company Online Training HERE and contact us to assist you further.
Download Brochure here
Course Fees
What are the fees for my country?
The Engineering Institute of Technology (EIT) provides distance education to students located almost anywhere in the world – it is one of the very few truly global training institutes. Course fees are paid in a currency that is determined by the student's location. A full list of fees in a currency appropriate for every country would be complex to navigate and, with today's exchange rate fluctuations, difficult to maintain. Instead we aim to give you a rapid response regarding fees that is customised to your individual circumstances.
We understand that cost is a major consideration before a student commences study. For a rapid reply to your enquiry regarding courses fees and payment options, please enquire via the below button and we will respond within 1 business day.
Engineering Institute of Technology (EIT) Certificate Course Payment Options
Please contact us with your location for certificate fees in the relevant currency. Certificate fees include all live webinars with a professional instructor, 4 technical manuals (as searchable eBooks), course materials, software, postage, assignments and ongoing support. All you need to participate is an internet connection, computer and headset. We have group discounts available for our 3 month certificates.
Engineering Institute of Technology (EIT) Advanced Diploma Course Payment Options
Three payment options are available for the Advanced Diploma courses;
Pay total amount upfront to receive a 5% reduction in fees.
Pay in 6 equal instalments over the duration of the course. First payment at least four weeks before the course starts. Payment dates will be set ahead of time and provided at the start of the course. You would receive the 30 technical reference eBooks in batches over the duration of the course.
Pay in even monthly instalments. First payment at least four weeks before the course starts, then one on the same date every month for the remaining period. This option incurs a 2% administration fee. You would receive the 30 technical reference eBooks in batches over the duration of the course.
Discounts are available for group bookings
For a rapid reply to your enquiry regarding courses fees and payment options, please contact us with your name, email address, course title(s), and location using the form below, and we will respond within 1 business day.
Engineering Institute of Technology (EIT) School of Electronic Engineering
- Professional Certificate of Competency in Power Electronics, Switch Mode Power Supplies and Variable Speed Drives for Electrical, Instrumentation and Control Systems
- Professional Certificate of Competency in Troubleshooting, Designing and Installing Digital and Analog Closed Circuit TV Systems
- Professional Certificate of Competency in Digital Signal Processing
Electronics engineering involves an intimate knowledge of the behaviour of electrons to develop components, devices, systems or equipment. There are many subfields such as biomedical engineering, power electronics, digital signal and image processing. In common with all of the Schools within the Engineering Institute of Technology (EIT), students in this field require a multi-disciplinary approach. Demand is assured for trained personnel in various engineering fields who also have a strong knowledge in the industrial applications of electronics.
Students in the EIT School of Electronics Engineering may specialise in subjects such as power electronics, switch mode power supply design, specification and technical writing, digital signal processing, embedded controllers, data acquisition systems and technologies, shielding, EMC/EMI noise reduction and analog/digital design and circuit board layout.
Click here to view FAQs


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News - 10 Mar 2014
To Elbow, with love from Yoko
Yoko Ono has written a letter to Elbow to thank them for mentioning her in their new song, New York Morning. Their lyric Its the modern Rome and folk are nice to Yoko references a statement made by John Lennon when he and Yoko left England.
New York has been kind to me as your song says. Thank you. For John, he always wanted to come and live in this city, ever since he saw Bob Dylan on the famous album cover (The Freewheelin Bob Dylan). And I played the catalyst to make his dream come true. Yoko Ono on imaginepeace.com
YOKO ONO INFINITE UNIVERSE AT DAWN captures moments from Yoko and Johns time in New York (including the inset photo, © Yoko Ono). To order your copy today, and have your name printed in this historic edition, click here.
Related titles...
Infinite Universe At Dawn
Yoko Ono
Hall of Fame
Sometime In New York City
Bob Gruen, Yoko Ono
'Walk through the park and there are people holding hands and kissing. New York is begin


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Psst! Did you know this is me?
I am a Full Stack WordPress Developer, WP Core Contributor, Front-end Fanatic and a Designer by night. I love to create optimized but advanced Workflows to produce cool pieces of Open Source software.Ahmad Awais
Psst! Did you know this is me?
Takeaway my professional opinion about Full Stack WordPress Development, building a business, growing a family, and everything web! Delivered to your inbox twice a month. 👻 I hate spam! Pinky Promise!


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6月 30, 2014 合計視聴数:: 5143 今日は: 2 ★★★
B2 Satitham (Wat Jedyod) Hotel Chiang Mai, Situated opposite to Wat Jed Yod, B2 Satitham (Wat Jedyod) Hotel is just a 5-minute drive to Nimmanhaemin Road. Designed in modern style, ホテルでは無料Wi-Fiと無料の専用駐車場を提供しています. B2 Satitham Hotel is a 5-minute ride from Chiang Mai Bus Station and 15-minute drive from Chiang Mai Train Station. それは、とり 15 minutes to drive to Saturday Walking Street, Sunday Walking Street, Night Bazaar and Central Airport. Each air-conditioned room features modern furnishings, フラットスクリーン·ケーブルテレビ, fridge and minibar. Shower facilities are included in an en suite bathroom. 余分な便宜のため, there is a 24-hour front desk. For security, a security guard and CCTV cameras are provided. Thai cuisine can be sampled at local restaurants nearby, which are just a 5-minute drive away. (B2 Satitham (Wat Jedyod) ホテル Chiang Mai hotels 予約).


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THE true Mason labors for the benefit of those who are to come after him, and for the advancement and improvement of his race. That is a poor ambition which contents itself within the limits of a single life. All men who deserve to live, desire to survive their funerals, and to live afterward in the good that they have done mankind, rather than in the fading characters written in men's memories. Most men desire to leave some work behind them that may outlast their own day and brief generation. That is an instinctive impulse, given by God, and often found in the rudest human heart; the surest proof of the soul's immortality, and of the fundamental difference between man and the wisest brutes. To plant the trees that, after we are dead, shall shelter our children, is as natural as to love the shade of those our fathers planted. The rudest unlettered husbandman, painfully conscious of his own inferiority, the poorest widowed mother, giving her life-blood to those who pay only for the work of her needle, will toil and stint themselves to educate their child, that he may take a higher station in the world than they;--and of such are the world's greatest benefactors.
In his influences that survive him, man becomes immortal, before the general resurrection. The Spartan mother, who, giving her son his shield, said, "WITH IT, OR UPON IT!" afterward shared the government of Lacedæmon with the legislation of Lycurgus; for she too made a law, that lived after her; and she inspired the Spartan soldiery that afterward demolished the walls of Athens, and aided Alexander to conquer the Orient. The widow who gave Marion the fiery arrows to burn her own house, that it might no longer shelter the enemies of her infant country, the house where she had lain upon her husband's bosom, and where her children had been born, legislated more effectually for her State than Locke or Shaftesbury, or than many a Legislature has done, since that State won its freedom.
It was of slight importance to the Kings of Egypt and the
p. 313
[paragraph continues] Monarchs of Assyria and Phœnicia, that the son of a Jewish woman, a foundling, adopted by the daughter of Sesostris Ramses, slew an Egyptian that oppressed a Hebrew slave, and fled into the desert, to remain there forty years. But Moses, who might other-wise have become Regent of Lower Egypt, known to us only by a tablet on a tomb or monument, became the deliverer of the Jews, and led them forth from Egypt to the frontiers of Palestine, and made for them a law, out of which grew the Christian faith; and so has shaped the destinies of the world. He and the old Roman lawyers, with Alfred of England, the Saxon Thanes and Norman Barons, the old judges and chancellors, and the makers of the canons, lost in the mists and shadows of the Past, these are our legislators; and we obey the laws that they enacted.
Napoleon died upon the barren rock of his exile. His bones, borne to France by the son of a King, rest in the Hôpital des Invalides, in the great city on the Seine. His Thoughts still govern France. He, and not the People, dethroned the Bourbon, and drove the last King of the House of Orleans into exile. He, in his coffin, and not the People, voted the crown to the Third Napoleon; and he, and not the Generals of France and England, led their united forces against the grim Northern Despotism.
Mahomet announced to the Arabian idolaters the new creed, "There is but one God, and Mahomet, like Moses and Christ, is His Apostle." For many years unaided, then with the help of his family and a few friends, then with many disciples, and last of all with an army, he taught and preached the Koran. The religion of the wild Arabian enthusiast converting the fiery Tribes of the Great Desert, spread over Asia, built up the Saracenic dynasties, conquered Persia and India, the Greek Empire, Northern Africa, and Spain, and dashed the surges of its fierce soldiery against the battlements of Northern Christendom. The law of Mahomet still governs a fourth of the human race; and Turk and Arab, Moor and Persian and Hindu, still obey the Prophet, and pray with their faces turned toward Mecca; and he, and not the living, rules and reigns in the fairest portions of the Orient.


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Zoom – The thing seems as if from far away, "zooming" ahead into posture (Marsh states he prefers utilizing this unique animation to incorporate emphasis to big factors)
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Thomas Carreiro, facing his fourth charge for operating under the influence, was denied bail until a judge can decide if he is a danger to society.
Thomas Carreiro, facing his fourth charge for operating under the influence, was denied bail until a judge can decide if he is a danger to society.
Carreiro, 55, of 130 Cambridge St., was arrested at 6:30 p.m. Wednesday inside a supermarket at the Maplewood Plaza, 440 Stafford Road. Police allege he had just walked into the market after driving his Nissan Pathfinder into a stack of shopping carriages and then into a parked car in the plaza parking lot.
"We got a call from several witnesses who reported the accident," said Police Lt. Roger LaFleur, a department spokesman. "Officer Peter DeLuz spoke with the witnesses, who saw a black Pathfinder collide with the shopping carts and then go around them to hit a parked vehicle.
"The operator then got out and went to the store to sit on a bench."
DeLuz reports he spoke with Carreiro and then asked him to perform field sobriety tests of reciting the alphabet and counting backwards from 100.
Carreiro, police allege, fell while reciting the alphabet and could not get from A to Z without errors. He also failed the test of counting backwards, police allege.
Court records report he took a Breathalyzer test and had a blood alcohol level of .17. The legal limit for driving is .08.
Carreiro was held in jail overnight and arraigned Thursday before District Court Judge Gilbert Nadeau.
The original charge was operating under the influence, third offense, but that charge was amended after prosecutor Patrick Driscoll checked the court record and learned this was Carreiro's fourth arrest on the charge. The previous arrests were in 1996, 1984 and 1978, court records show.
A dangerousness hearing is scheduled for today in District Court to determine if Carreiro should be granted bail while awaiting trial.
If Carreiro is deemed dangerous and denied bail, the prosecution must be ready to try him on the charges within 60 days.
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