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Dave & Buster's
Oklahoma City, OK 73112
Dave & Buster's in Oklahoma City is an American restaurant and entertainment facility. Fun at Dave & Buster's...Learn More
Dave & Buster's in Oklahoma City is an American restaurant and entertainment facility. Fun at Dave & Buster's...Learn More
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Late nights have their own rhythm, especially in Tulsa. Tune into the after-hours atmosphere at Riffs, the perfect spot...Learn More
The nearest gaming and entertainment venue to downtown Tulsa, the Osage Casino offers guests more than 1,000...Learn More
The Soundpony, located in downtown Tulsa right next door to historic Cain's Ballroom, is a low-key place where you...Learn More


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Paradox IP150 Internet & IP Ethernet Module
Provides access to the iParadox Smart Phone App
The IP150 Internet Module is an HTTPs-supported IP communication device that enables you to control and monitor your security system through any web browser (e.g., Google Chrome). The IP150 provides freedom to access your system and receive instant, SSL encrypted email notifications anywhere in the world when your system detects activity. So no matter where you are, you will have access to arm, disarm, and more.
Feel free to ask any questions by dropping us a line or calling 1300 004 226
$147.36In Stock
- SSL support for sending secured emails via a secure sockets layer; a protocol for encrypting information over the Internet
- HTTPS Secure support for improving security (HyperText Transfer Protocol Secure; a widely used communications protocol for secure communication over a computer network)
- Two I/Os on board; controlled via the web interface, triggering an email
- Event log on web interface; displays last 64 events
- Easy installation; built-in clip for mounting in a metal box
- Panel Compatibility:
- Any Digiplex EVO panel (V2.02 for IP reporting)
- Any Spectra SP series panel (V3.42 for IP reporting)
- Any MG5000 / MG5050 panel (V4.0 for IP reporting)
- Any Esprit E55 (does not support IP reporting)
- Esprit E65 V2.10 or higher
- Browser Requirements: Optimized for Internet Explorer 9 or higher and Mozilla Firefox 18 or higher, 1024 x 768 resolution minimum
- Encryption: AES 256-bit, MD5 and RC4
- Current Consumption: 100mA
- Input Voltage: 13.8VDC, supplied by the panel serial port
- Enclosure Dimensions: 10.9cm x 2.7cm x 2.2cm (4.3in x 1.1in x 0.9in)
- Certification: EN 50136 ATS 5 Class II
|Shipping Weight
|Shipping Width
|Shipping Height
|Shipping Length
|Shipping Cubic
Works as advertisedBy: The Installer on 8 July 2016This module works as advertised, providing email alerts and web based access to the status of the alarm panel. The only minor issue may be the availability of the software you need to 'discover' the module on the network. It can be difficult to find if you don't have a Paradox logon, however it is on the internet if you look around.

subset: commoncrawl


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Good quality product
Does exactly what you want it to do. Quality product. Dimpled back, to improve grip. Buttons not impeded in anyway. Side bumpers slightly wrap round front screen creating a rised edge adding more protection to screen.
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Submitted by: Gwen Campbell (Jacksonville, NC)
"This fragrant, citrusy bread will give you a jumpstart on your day."
>> Need an Amish Friendship Bread Primer with the ten day instructions? Go here!
Prep Time: 15 minutes
Cook Time: 1 hour
Servings: 16
Yield: 2 loaves
1 cup Amish Friendship Bread Starter
3 eggs
1/2 cup milk
1 cup applesauce or oil
1 teaspoon orange extract
2 cups all-purpose flour
1 1/2 teaspoons baking powder
1/2 teaspoon baking soda
1/2 teaspoon salt
1 box orange Jell-O gelatin
1 box instant vanilla pudding
4 tablespoons International Coffee Orange Café
Orange Glaze (optional)
- Preheat oven to 325° F (165° C).
- Combine all wet ingredients.
- Combine all dry ingredients and add to wet.
- Mix thoroughly.
- Prepare two loaf pans with butter or nonstick spray and sugar.
- Divide batter evenly between pans, top with sugar.
- Bake for one hour or until the bread loosens evenly from the sides and a toothpick inserted in the center of the bread comes out clean.
Kitchen Notes
From Gwen Campbell: "When I make this again, I will be using orange juice in place of the milk and orange zest in the batter along with the orange extract. An orange glaze or vanilla glaze would be fabulous with this."
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The Guest Room
Musings, Memories & Epiphanies Inspired by Place
El Cardonal, Baja – A World Unto Itself
"Travel is fatal to prejudice, bigotry, and narrow-mindedness, and many of our people need it sorely on these accounts. Broad, wholesome, charitable views of men and things cannot be acquired by vegetating in one little corner of the earth all one's lifetime."
Just over 1,000 miles south of the U.S./Mexico border is the town of Cabo San Lucas and just about an hour or so north of Cabo is the town of Los Barriles. And if you drive another hour beyond that, you'll arrive in El Cardonal.
The drive from Cabo to Los Barriles is not exactly an easy drive, and it's a drive you would be well-advised not to make at night, but it's not a bad drive and truth be told it is pretty much fabulous if you open your mind. Baja is a picture of contrasts; the desert on one side of you and the Sea of Cortez on the other. Driving along the two-lane roads one is quite likely to cross the path of a cow or two, many roadside makeshift memorials and if you're lucky enough (or if you're with someone who's in the know) you'll come across an open air cantina that serves amazing cucumber margaritas. Once you reach Los Barriles you'll find a relaxed comfortable town where everyone is friendly and welcoming. There are quite a few gringos who live amongst the locals and they do so because they've embraced the beauty and culture of Baja. While major shopping such as Costco and Mega are offered in Cabo, Los Barriles will keep you in the essentials along with homemade tortillas and freshly roasted chicken; because really, what else do you need? Well, a good bottle of Tequila but that's another story. And by the way, the Costco in Cabo has probably the most fantastic view you'll ever see from any Costco parking lot, ever.
Heading out of Los Barriles it isn't actually that far to El Cardonal, maybe 15 – 20 miles, but it takes a bit of skilled driving to reach the town by the paved mountainside road. There is also a dirt seaside road that extends between Los Barilles and El Cardonal but because it will make your teeth rattle, it's more of a one day just for fun, or only when bad weather road conditions dictate, kind of road. As a result of the road conditions and the remoteness of the area, (and the cows in the road) it does take about an hour of slow-moving driving to reach El Cardonal, but it is well-worth the effort. And that's easy for me to say because I wasn't doing the driving.
Finally, you'll come upon El Cardonal. It's a sleepy little seaside village where I'm pretty sure everyone knows everyone else. There is no traffic and there is no noise other than a few crows of the local roosters.
To the untrained eye one might jump to the conclusion, when first visiting El Cardonal, that there is a great deal of poverty but one would be wrong. Some of the homes may have dirt floors, but the children are well-cared for, thriving and they go to school in freshly pressed clothing. What El Cardonal has to offer is a lifestyle choice, the importance of family and quality of life take precedence over material possessions. It is a world unto itself and I'm fairly certain the locals have discovered the key to a happy life.
The daily life of those who are fortunate enough to make El Cardonal their home is not altogether different from any other, they just happen to live where the desert meets the sea. The locals (and gringos) fish the waters of the Sea of Cortez and either sell or serve their catch. Local residents Antonio and Yolanda own an open air restaurant where they serve the freshest catch of the day. Their son, who was educated in La Paz, works in a medical clinic in nearby Los Barilles.
Albeit a small village, El Cardonal offers up pretty much anything needed from fresh tortillas to ice cold beer to drinking water delivered to your home's underground storage tank. There is a church on a hill, a brightly colored school where the playground has a view of the sea and a lumberyard. There is an auto mechanic, Cezar, who can fix just about anything and I'm told he has a voice that brings people to the dance floor.
On my two trips to El Cardonal, I learned that what I was witnessing was a true quality of life, having what you need without all of the excess stuff. It is an exercise in perspective. I remember one time in particular when we were driving the long dirt road (outside of El Cardonal) to the home of our friends when we came upon a man who was walking home from work. Our friends stopped and offered him a ride. After the man got out of the car I asked my friend, "Does he make that walk every day?" The answer was yes, and while we only drove four miles to their home, he continued on even further. No big deal, it is just part of life; you have a job to do, you do it.
El Cardonal is a little stretch of paradise on the Sea of Cortez. Our visits there have been twofold in purpose; to spend time with lifelong friends and to be in such a remote area where it forces you to be quiet. It rejuvenates the soul. One can't help but relax while walking the sandy beaches of the sea where you can watch whales swim by, or catch more fish than you know what to do with, or witness the glorious sunrises and sunsets which are absolutely stunning! More importantly though, being there allows you to just breathe. To learn more about the whales near El Cardonal: http://www.urmkal.blogspot.com/
It's an easy flight from Los Angeles, CA to Cabo San Lucas, just a bit over two hours and the views from the airliner windows are really something to see. I'm not a particularly brave person and I'm diligently watchful of my surroundings, but I can honestly say I've never felt anything but comfortable in Baja. The locals are kind and giving and if you just do your homework and pay attention to your surroundings you'll be fine. There are of course issues, but there are issues everywhere, no matter where you travel. Oh, and yes, it is in fact safe to drink the water in Baja. I have to admit it wasn't until the 2nd trip that I was convinced, but I am now.
Tenga un viaje seguro!
Thank you to R. Dressler of San Isidro, Baja, for the photos used in this article and also thank you to those who shared their lives.
Patti, and her husband, Abi, own and operate Abigail's Bed & Breakfast Inn in Ashland, Oregon. When they are not hosting guests, they are slowly but purposely traveling the world. Patti writes a travel blog, One Road at a Time.


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- Treatments
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- 35-44 year old woman...
35-44 year old woman treated with Brazilian Butt Lift
*Treatment results may vary
Was this photo helpful? {{ voteCount + ' other' + (voteCountOthers == 1 ? '' : 's') }} found this helpful
This photo demonstrates the immediate impact of the Brazilian Butt Lift. A total of 3 liters of liposuction was performed and 650 cc of purified fat was grafted to each buttock. The end result is dramatic improvement in the contour of the hips, flanks, abdomen and thighs with the creation of a well rounded and shaped buttocks.


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|iPhone apps
DirtLand has to be one of the best action packed shooter game available for the iPhone/iPod.
Catch items that fall to increase firepower, bullet, speed, etc
- Endless Gameplay
- Different Types Of Waves
- Amazing Retina Support
- Catch Power ups
- Touch Left and Right screen to Move, EASY CONTROLS!
- Amazing Sounds
- Play Against Friends, try to beat each others score
Priced For Only $0.99!
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The information may be outdated (2011-04-25 09:45:59). For actual information go to iTunes


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Thiruvananthapuram, May 24: The South-West monsoon hit the state of Kerala on Saturday, 8 days ahead of its usual schedule. Usually the monsoon arrives in the 'Gods own country' on Jun 1.
A B Mazumdar of Indian Meteorological Department (IMD) said, "Though the monsoon arrived early in Kerala, it will be hard to say whether it will hit Maharashtra earlier than its usual time, since the wind currents are weak at present." As per its normal schedule, the monsoon reaches Maharashtra coast on Jun 7.
Monsoon which reached Andaman islands on Wednesday, May 20, entered Arabian Sea on Monday, May 22 as per the normal timetable. But it picked up speed to reach south Kerala well in advance. It has also reached some parts of south Tamil Nadu, most parts of south-west and east-central Bay of Bengal and some parts of the west-central and north-east Bay of Bengal.
OneIndia News


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Director, NextLA
Inspiring, preparing & connecting L.A.'s young professionals
Formerly known as the L.A. Junior Chamber of Commerce, we're back as NextLA … and we are ready to empower YOU to join the Next generation of leaders! Join us as we celebrate the re-launch of NextLA, the exciting new iteration of the iconic L.A. Junior Chamber of Commerce. New name… same core purpose: to inspire, prepare and connect L.A.'s Young Professionals for the future. Professional development. Civic engagement. And meeting a LOT of incredible people!
Los Angeles! We are back…
and ready to empower YOU to join the Next generation of leaders!
Let's get social…
Upcoming Events
Come out and join us!
Saturday, September 30 – 9 a.m.
What's the best way to stand out on the job and advance in your career? Be a great leader. Great leaders are men and women of high character and high competence who manage themselves before they try to influence others. Paul Butler of Newleaf returns to NextLA to provide an in-depth look at modern leadership. This program includes a thorough self-assessment along with real-life examples, powerful case studies, participative exercises and an action-oriented format. You'll leave with a greater ability to bring out the best in the people you lead and increased potential for promotion and success.
Breakfast will be provided.
Capacity: 30
Price: $15 for NextLA members, $40 for non-members
Location: Cross Campus DTLA
Saturday, September 23 – 10 a.m.
Introducing NextLA's signature volunteer program in partnership with LA Works! Inspire a lifelong love of reading in a group of LA first graders. Volunteers will meet monthly to participate in reading and art activities with students at 49th Street Elementary School. You'll have the chance to work with kids one-on-one and in small groups. No teaching or art experience necessary!
Saturday, October 7 – 10 a.m.
NextLA members only! We'll join the UCLA community for their annual Volunteer Day of community service. NextLA volunteers will supervise volunteer groups of 10-25 students on a painting and beautification project. Hone you leadership skills, give back to your community, and have fun!
When registering, choose "Task Captain" as your role, "Lincoln Park" under "ZIP Code / Area," and "NextLA" under "Groups."


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Treat for Taranaki's Central Pulse fans
The Central Pulse will take on 2012 champions Waikato-Bay of Plenty Magic in a pre-season netball match in New Plymouth in February.
In a first since the inception of the ANZ Championship, Taranaki will host the two teams at the 1900-capacity TSB Stadium.
The February 23 game will cap off an exciting weekend of netball activity. Not only will fans have an opportunity to see the players in action, but young netballers will also get the chance to train with Pulse players and learn new skills.
Taranaki year 7 and 8 netballers will play a North v South curtain-raiser on Saturday. After the main game there will be a chance for fans to meet the Pulse and Magic players and get their autographs.
Winners of the "Train with the Haier Pulse Players" competition will take part in one of two netball clinics on the Sunday.
Including the Pulse players, each clinic will cover skills and drills on footwork, space and balance. The sessions are also open to view by the public so everyone gets the chance to pick up a few netball tips.
Netball Taranaki general manager Jacqui Jones said she was delighted that Taranaki was to host the pre-season event.
"Every one of our registered players, officials and teams contributes through their fees to the development and delivery of netball region and nationwide," she said.
"We're delighted that a game at this level is being played in Taranaki and that there is such a strong commitment to community engagement while the team is here."
The game starts at 4pm, with tickets on sale from Friday, December 14, priced at $16.50 for adults and $6.50 for children (2-12 years).


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If you have any questions call us on 01234 834667 or email firstname.lastname@example.com. Thank you!
Pint Sized Giants
Web Design & Marketing
Email: firstname.lastname@example.com
Bedford I-lab,
Stannard Way,
If your marketing and web design agency isn't giving you the service you used to receive, or is unable to move forward with new marketing strategies and web design trends, then it's time to call Pint Sized Giants.
"I'm paying too much for simple work" and "I'm not achieving results through my website and marketing" are two complaints we often hear from new customers talking about their old agency. We have made it our mission to ensure that every customer of ours feels valued and is listened to, as our job is to successfully market YOUR business.
Our dedicated team is used to working with clients from all over the UK, in a wide variety of different industries. To find out how our team can help your business become more successful, email, call, or organise a face to face meeting with one of our account managers today. Tell us what's not working for you and we'll tell you how we'd do better. There are no forms or hidden fees. We make it simple and easy to change!
We get to know you and your business in order to come up with a strategy that is suitable to your business aims and targets. Whether you want to increase your customer base, encourage loyal customers to buy more, or you just want to increase your brand's presence, our team of specially trained marketers, developers and account managers will help you achieve your goals.
Switching is easy. We will help you through the whole switching process, making sure you get everything you need from your previous agency, and utilising all of the materials you give us. Whether you are looking to keep your old website, or have a new and on-trend site designed, we can make sure your website fits in line with your marketing strategy, ensuring you get the most out of your investment.
You already know that to be successful, your business needs to connect with people. The longer you leave it, the more you are missing out. We help to turn things around for new clients every day, and we know we can help you too.
Just So you know! You can download our web design and marketing product pack here: Product Pack.


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After foolishly deluding myself yesterday that the reason I hadn't heard from mum about my letter was because of a problem with royal mail I spoke to both my folks on the phone last night. Mum had in fact got the letter earlier that day, and sounded exceptionally upset and tearful, in fact she seemed a little more upset than she was when her father died. After I'd recovered from hearing her voicemail and called her back she also sounded a little drunk, which perhaps didn't help.
Thinking about the pain and sadness in her voice is horrible. I now feel quite stupid that I really didn't expect her to react quite so badly to this. I'd naively hoped that having already gone through this with one daughter she might be prepared to be understanding when it happened again. If anything she seems to be worse this time around.
I had very little idea of what dad's reaction would be…I'm not sure which of the two was worse. To him though this was the perfect opportunity to point out to me that my life (ie job) is lacking direction and I need to get my act together, talking about my sexuality was 'an irrelevant distraction from what I really need to do'. As well as listing these parts of my life that apparently make me a woeful disappointment as a person and the evidence of how self-indulgent I was, he felt a need to come out with some utterly breathtakingly hurtful comments about my ex. In particular 'When I met him I knew he or should I say she, had something weird about him. That much was obvious'. Attacking someone who I always saw as, and always was a man, and a he, who I loved was just low and really unnecessary.
Today I'm still reeling from the whole thing, intermittently feeling like I want to burst into tears or be violently ill. There's the blow to my self-esteem which in regards to my career was really not high before, the shame and sadness at the pain I've caused, and the anger and disgust I feel towards my dad, who I'm frankly ashamed to be related to.
I'm currently trying to remind myself that this will pass. As the youtube videos all say, it does indeed get better. I just never imagined, once the stress of anticipation had passed that I'd feel in this much pain.
My logical (as opposed to biological) family of friends have been nothing but brilliant. As a friend of mine put it when I remarked that I couldn't understand why my dad felt a need to be such an arsehole 'But he is an arsehole, you knew that already. That's kind of what he does'.
I'm looking forward to spending some time with A, who is a constant reminder of how worthwhile this whole difficult process has been. With the interrupted, light, nightmare-filled sleep I've been having lately I'm quite tempted to go back to my doctors and ask about maybe getting a short prescription for sleeping tablets (not a cheering thought given that I'd hoped to be able to start the process of weaning off my anti-depressants in the spring, but might be necessary if I don't get this sorted).
Comfort reading and other assorted blankee-like coping mechanisms beckon. Wearing a constant layer of war paint is helping (how on earth do men cope in a personal crisis without being able to apply a layer of slap to distract from their problems and put on a brave face to the world?).
My own letter wasn't nearly so eloquent, and could never capture the experience of a generation like this letter does:
I urge anyone regardless of their orientation to read this, as somehow it still rings bells for me, and I imagine for so many people taking the first scary steps to come out to your parents.


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I won't do this often, I promise. But i thought I'd share the vid from my performance at my school's talent show today. I used to be one of these. About three years ago. I'm pretty rusty, but I sure had fun. My out-of-cheer-shape body may be singing a different tune tomorrow.
Out of the Ordinary
Posted by alli s. miles at 3:19 PM
Labels: Assorted: Nadou
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Earnest. It's the perfect name for a sweet, eager-to-please yellow Labrador retriever. Anna and her boyfriend Jeff fall for him the minute they see those guileless eyes gazing up from behind his gate at Seattle's Best Friends Shelter. In no time at all, they're a pack of three, with Earnest happily romping in their condo on Gamble Island.
During the day, Earnest keeps Anna company in her flower shop, located in a historic gingerbread Victorian on the island's main street. Anna hopes to buy and restore the house, once owned by her beloved grandmother. But when that dream is threatened by Jeff's actions, Anna's trust is shattered. For so long, the house has encompassed all her ideals of security, home, and family. Yet Earnest's devotion to his two people, and theirs to him, make it impossible for them to walk away from each other. And when a crisis hits, it's Earnest - honest, stubborn, and uncannily wise - who will help Anna reconcile her past and embrace what the future can bring.
©2016 Kristin von Kreisler (P)2017 Tantor
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Deep Impact ready for finale
Deep Impact should conclude his brilliant career on a high note at Nakayama on Sunday when he attempts to win the one Japanese race that eluded him last year, the $2.9 million Arima Kinen, or Japanese Grand Prix.
The traditional year-end 1 9/16-mile Grade 1 event has greater cachet in many Japanese racing circles than the Japan Cup, a race Deep Impact won on Nov. 26 after having been disqualified from third place in the Prix de l'Arc de Triomphe for a banned-drug positive.
The Arc and last year's Arima Kinen are the only times in 13 career outings when Deep Impact, a Yasuo Ikee-trained 4-year-old son of Sunday Silence, failed to cross the line in front. Nearly 100,000 people are expected at Nakayama to say good-bye to their hero, who is likely to go off at 1-10 with Yutaka Take on board.
The biggest spoiler at the farewell party could be Daiwa Major. A late-blossoming 5-year-old son of Sunday Silence, he has won at the Grade 1 level in his last two starts, the 1 1/4-mile Autumn Tenno Sho and the Mile Championship.
The 3-year-old Dream Passport is a threat off his fine two-length second behind Deep Impact in the Japan Cup, in which Ouija Board was third.


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Investment Services Representative 105492
Company Apply Now
Our client located in Altoona, PA is seeking a successful candidate to fill the role of Investment Services Representative.
Successful candidate for this full-time, direct-hire position will be responsible for the sales and distribution of non-deposit insurance, investment, and financial service products to meet customer needs.
The chosen candidate must possess initiative and drive and be highly organized and a self-starter; ability to interface effectively and professionally with customers and all levels of bank personnel; ability to perform responsibilities with sound judgement; proficient reading, writing, grammar, and mathematics skills; proficient interpersonal relations and communicative skills; proficient PC skills; thorough understanding of all non-traditional financial products and services; valid driver's license along with dependable vehicle.
A Bachelor's degree or comparable work experience and three years of experience in the sale of insurance, investment, and other financial service products; current Series 6, Series 7, Series 63, and PA Life, Accident, and Health Insurance designation securities licenses are required.
Please submit resume for consideration.
Resume must be submitted in the following formats: .doc, .docx, or .rtf


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Zadaca Digital Media
Agency expert in Social Media.
About Zadaca Digital Media
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We create projects that live on in digital space at Zadaca Digital Media, which has unveiled the digital projects of the biggest brands of Turkey since 2003. We do not categorize nor differentiate any project we undertake, under the name of corporate sites, micro-sites, brand sites, advergames, e-trades. We believe that every project existing in digital world is a result of an idea and every idea has a cause. For this reason, each of our designs serves an idea. Our strength in design reflects to our name, our care for details to trust, our ideas to our uniqueness. Every project we create survives, we keep on standing behind each of our surviving projects. We accept and undertake the projects, only in which we have faith. We make a difference in every project we create, thanks to our multilateral strategy, designing strength, communication skills and sense of customer-oriented solution and production. Zadaca has always been ranked within the top three actors in many surveys, regarding the most creative and the most famous digital agencies in Turkey, carried out by independent bodies. Web Design, Web Development, E-commerce, Microsite, Advergaming, Social Media, Digital Marketing & Strategy, Digital Advertising, Online Campaigns, Mobile Application, Facebook Games, Viral Videos, Illustration, Content Generation, SEO & SEM, Facebook Ads, Media Buying
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We now seem to live in a small world, in which everyone is highly interconnected. Cells, too, often also display tremendous interconnectivities in their component systems. As a recent case in point, we have identified a conserved protein complex—the SEA complex—that links the nuclear pore complex (NPC), the COPII vesicle coating complex, vacuoles and autophagy. In this punctum we will discuss the properties of this novel complex.
The SEA complex, found in yeast, contains the nucleoporins Seh1 and Sec13, plus four previously uncharacterized proteins (Sea1–Sea4). This complex also contains Npr2 and Npr3, which Neklesa and Davis recently found during a genomewide screen for regulators of TORC1 in response to nitrogen starvation; Npr2 and Npr3 specifically inactivate TORC1 when amino acids are scarce. Signals indicating an abundance of nutrients activate TORC1 (and deactivate autophagy), whereas signals of starvation or other stressors inhibit TORC1 (and activate autophagy). Accordingly we reasoned that, in the absence of Npr2 and Npr3, TORC1 is hyperactive, and that therefore autophagy should be impaired. Indeed, after nitrogen starvation, the vacuolar autophagy marker GFP-Atg8 was blocked in the cytoplasm in the npr2Δ strain and distributed equally between the vacuole and the cytoplasm in the npr3Δ strain, indicating impairment in autophagic processing. Therefore Npr2 and Npr3 can be considered as novel regulators of autophagy. Despite this important role, very little information is available about these proteins; hence, we would like to highlight here several findings that we made during the initial characterization of the SEA complex.
The SEA complex was discovered during immunopurification of a tagged version of one of the components of the NPC, the nucleoporin Seh1. As a bona fide nucleoporin, Seh1 co-purifies with the Nup84 subcomplex, a key component of the NPC's membrane-hugging scaffold. However, Seh1 also co-purifies with Npr2, Npr3, Sec13 and four high-molecular-weight proteins [Yjr138w (Iml1), Yol138c (Rtc1), Ydr128w (Mtc5) and Ybl104c)]. To reflect their association with Seh1, these proteins were given a common name, Sea (for Seh1-associated), and were renamed Sea1 through Sea4, respectively. Tagged versions of each of Sea1–Sea4 co-purified with each other, and with Seh1, Sec13, Npr2 and Npr3. Sec13 is also a member of the NPC's Nup84 complex (above). In addition, Sec13 interacts with Sec31 in ER-trafficking COPII vesicles; however, we do not find other NPC proteins or members of COPII vesicles associated with the SEA proteins, and the SEA proteins do not localize to the NPC or ER, confirming that this group of proteins forms a novel and distinct complex, entirely separate from the NPC or COPII.
Previously, Seh1 and Sec13 had only been shown to function as part of membrane coating assemblies—NPCs and coated vesicles. Coated vesicles are membranous transport intermediates, encapsulated by distinctive proteinaceous coats such as those formed by the COPI, COPII or clathrin complexes. NPCs are embedded within the nuclear envelope and are the sole mediators of macromolecular nucleocytoplasmic exchange. The structural scaffold of the NPC, comprising ~50% of the total NPC mass, is formed almost entirely from proteins consisting of only two folds, a-solenoid-like and β-propellers, including proteins with a particular arrangement of an amino-terminal β-propeller followed by a carboxyterminal α-solenoid. The same structural modules dominate the major coated vesicle complexes, including COPI, COPII and clathrin. We previously proposed the "protocoatomer hypothesis," suggesting that various coated vesicles and the scaffold of the NPCs originated from a common evolutionary ancestor. Given that the SEA complex contains protein also found in the NPC and coated vesicles, we explored whether the SEA proteins also resemble proteins found in coating complexes by analyzing the fold compositions of their constituent protein domains. Strikingly, key Sea2–Sea4 proteins are predicted to possess the "protocoatomer" β-propeller/α-solenoid architecture. The SEA complex contains five proteins with β-propellers, a domain common in coating assemblies where it provides a molecular scaffold for protein interactions. Sea4 contains an N-terminal β-propeller, an α-solenoid and a C-terminal RING domain. Three SEA complex subunits, Sea2–Sea4, have a C-terminal RING domain. The high frequency of RING domains in the SEA complex suggests that the complex may act as an E3 ligase. Sea1 is a multidomain protein carrying an N-terminal Cdc48-like domain found in several AAA-ATPases, such as Sec18/NSF, immediately followed by a vWA-like domain, present in many membrane interacting proteins, including Sec23 of COPII vesicles. Sea1 also carries a DEP domain, which mediates interactions with membrane-bound receptors. Unfortunately, our analyses were unable to assign folds for Npr2 and Npr3. However both proteins seem to contain disordered regions and uncharacterized folds, the latter suggesting that suitable templates do not yet exist in the PDB.
We noticed that the predicted fold composition of several SEA proteins resemble those of proteins found in the HOPS and CORVET complexes, which have been implicated in tethering membranes together prior to their fusion. One of the major common defining features of NPC, coat and tethering proteins is their association with membranes. We found that the SEA complex proteins seem to be organized into large assemblies that dynamically associate with the vacuolar membrane surface. Despite this, deletion of one or several SEA members has only a minor effect on the examined vacuole functions, suggesting that the SEA complex functions alongside other related complexes and may be redundant under numerous growth conditions. We further tested whether SEA mutants are sensitive to rapamycin treatment and nitrogen deprivation. Growth of single deletion strains of SEA2–SEA4 is not affected by rapamycin treatment. However, doubledeletion strains exhibit increased sensitivity to rapamycin and reduced survival upon nitrogen starvation. Consistent with all these observations, SEA complex synthetic genetic interactions implicate its members in multiple interactions with genes responsible for amino acid biogenesis and sorting, membrane trafficking, autophagy and ubiquitination.
Taken together, the SEA complex demonstrates remarkable relatedness at the structural and compositional levels to characterized vesicle coating complexes, and appears structurally most closely related to the HOPS/CORVET tethering complexes. Untangling the web of interactions and redundant functionalities of this newly identified complex will be the next challenge.
S.D. is grateful to the support from Fondation de France, Fondation pour la Recherche Medicale and Fondation Gustave Roussy. M.R. is supported by NIH grants RR022220 and GM62427.
Punctum to: Dokudovskaya S, Waharte F, Schlessinger A, Pieper U, Devos DP, Cristea IM, et al. A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics. 2011;10:M110.006478. doi: 10.1074/mcp.M110.006478.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Soundgarden Fans React to Death of Frontman Chris Cornell, a Week Before Bomb Factory Gig
Chris Cornell was found dead in his Detroit hotel room Wednesday night.
Mike Brooks
The sad news spread quickly this morning that Chris Cornell, frontman of Soundgarden, Temple of the Dog and Audioslave, was found dead last night in a hotel room in Detroit. It was mere hours after Soundgarden performed at the Fox Theatre. He was 52.
The band was set to come to North Texas next Friday. They were to play the Bomb Factory with opening act Dillinger Escape Plan. The last two times Soundgarden came through town were in 2014 and 2011, when it played Gexa Energy Pavilion and Verizon Theatre, respectively. Cornell also played the theme song he wrote for the movie 13 Hours during its world premiere at AT&T Stadium in January 2016 in Arlington.
Soundgarden hasn't released a new album in five years, but that didn't stop it from hitting the road this year. The Seattle-based four-piece didn't need to play new material to make fans happy; it already had plenty of winners from albums like Badmotorfinger, Superunknown and Down on the Upside.
Cornell, who was originally the band's drummer, took the frontman role early in the band's career, helping it become one of the standout bands on Sub Pop Records. It moved to A&M Records with 1989's Louder Than Love and continued on a crest upward through the rest of the '90s until its breakup in 1997.
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Cornell embarked on a solo career, which resulted in four solo albums, and he fronted Audioslave for three albums. Plus, he had his supergroup Temple of the Dog, which included members of Malfunkshun, Mother Love Bone and Pearl Jam.
Temple of the Dog released its sole album in 1991 and had reunited in the last couple of years. Until the end, Cornell was a magnetic presence. His otherworldly vocal range was often compared to Robert Plant's.
In Soundgarden, guitarist Kim Thayil, bassist Ben Shepherd and drummer Matt Cameron provided him the backup he needed to shine. None of the them had lost any power on his instrument.
Fans and contemporaries flooded the internet with tributes minutes after Cornell's death was confirmed. Plenty came from DFW musicians.
"Soundgarden was one of the very first bands that got me into rock music," says Stephen O'Sicky of Caterpillars. "Chris Cornell's voice was one of a kind. So powerful. Soundgarden was a huge part of my childhood. We truly lost a grunge legend."
This sentiment is echoed by Dead Mockingbirds drummer Matthew Crain, who used to play Soundgarden's songs frequently in the grunge cover band Seattle. "Chris Cornell was someone who I always looked up to," Crain says. "With all the projects he was a part of, we have a lot to remember him by. That doesn't make the news any less difficult to accept."
Crain had tickets to see the show next Friday. "I still plan on being in the area to see if there is any tribute Dallas people have," he says. "This is a sad day for musicians and music in general as we lose a great talent. I feel blessed to have seen them before as Soundgarden and Chris as a solo act and feel lucky to have experienced both."
The Observer reached out to AEG, which booked the show at Bomb Factory, to confirm its cancellation. We have not yet heard back. At the time of writing, tickets are still being sold on the venue's website. It is not clear whether refunds will be offered if the show is indeed canceled.
Update: Bomb Factory has since cancelled the show. "Due to the untimely passing of Chris Cornell, Soundgarden will cancel the remainder of their scheduled tour dates," a message posted to the venue's Twitter Friday morning reads. "Ticket holders may obtain refunds at the point of purchase; online ticket buyers will automatically be refunded. Please allow 5-7 business days for the refund to process."
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Tuesday, December 28, 2010
The Top Ten Things I loved about this Christmas
1. Mulled wine
As you may have gathered from my photos in Turkey Tips from Toiv, we work in an open-plan office with six desks facing each other. We have called our area "The Eastern Bloc" in recognition of the fact that most of us come from Eastern European descent. This year, the Eastern Bloc decided to have a Christmas sweater party that was a raging success. Everyone brought some baked goods and I volunteered to make mulled wine. I have never made mulled wine before, but it seemed simple enough. Follow this recipe and you can't go wrong:
Mulled Wine
2 oranges
12 cloves
4 cinnamon sticks
1 whole nutmeg
1 sliced lemon
1 bottle red wine
1/2 cup of sugar
This was not the recipe I originally followed, but I made some adjustments and the above seemed to be the batch that most people enjoyed. It is, of course a matter of taste. Begin by brewing a cup and a half of water with the sugar, herbs and fruit. Once the mixture has reached a boil, reduce heat and let cool for 20 mins, then add the wine. Serve immediately. The smell is ridiculously delicious and made the office smell the way you always hope your home smells at Christmastime (realistically though, mine probably smells like a pine candle, a litter box, and gluttony).
As mentioned, it was a Christmas sweater party, which resulted in:
2. This Photo of Sharla and Brown Santa
Not only did Nin wear a woman's cardigan that his wife bought especially for this occasion, but Sharla wore a 14-year-old Rudolph sweater with a built-in red light complete with battery pack:
Christmas vomited on them and it makes me very, very happy.
3. High Tea at the Wedgewood Hotel with Lana and Paul
Lana and her boyfriend Paul invited me to high tea with them, where we lingered in front of the fireplace for hours drinking Kir Royales and hot English Breakfast tea. Look how cute they are:
I love love!
4. Eggnog Pie
I found this recipe online, made it for the office party, and it was such a hit I made one for Christmas dinner. It takes about 5 seconds to make and tastes like frolicking with wood nymphs in an enchanted forest (or something):
Eggnog Pie
1 frozen pie shell
2 cups whipping cream
1 1/2 cups eggnog
2 tablespoons rum
1 teaspoon nutmeg
1 package non-instant vanilla pudding
Follow directions on the pie shell box, bake and allow to cool. In a saucepan, heat eggnog and add vanilla pudding mix. Whisk until thoroughly blended, remove from heat when large bubbles appear. Add nutmeg and rum, place in fridge to set.
Whip the cream until stiff peaks appear. Once set, remove the pudding mix and beat until fluffy. Fold whipping cream and pudding mix together, then pour into pie shell. Top with nutmeg, then allow to chill overnight.
I mean, look at this thing:
5. Pomegranate Martinis
On Christmas Eve, my mum and I like to have a little Christmas cheer and watch White Christmas, with Rosemary Clooney and Bing Crosby. This year, I decided to make simple pomegranate martinis with muddled pomegranate seeds, lemon juice, ice cold vodka and pure pomegranate juice. A lovely way to cap off the evening!
6. Mum's Curry
Another thing we like to do on Christmas Eve is make prawn coconut curry. Well, I make the rice and do some prep, then it's all mum. I don't know what it is with this woman and curry but she knocks it out of the park every single time. Since it was Christmas, we used a whole bag of frozen prawns, chopped up a handful of cilantro, a shallot, and a whole bag of Asian Family red curry sauce, which has lemongrass and coconut milk already mixed in. We served it over basmati rice and it was the best meal I had in ages:
7. This Pot
Santa (my mum) brought me my very first piece high-quality cookware: this stainless steel beauty I have named Edith (Edie for short). She and I cooked orzo together last night. I think it's love.
8. Stella's Holiday Collar
Stella is generally a good sport when it comes to putting up with my overloving her, dressing her up, and hugging her every five minutes. I found a Christmas collar at the dollar store and since she tore apart her reindeer antlers from last year, I figured it was time to renew her holiday spirit:
Something I didn't anticipate? Mad Stella is a ringer for Mad Carri. To wit:
9. Holiday Log
About 5 years ago I bought this DVD for $4.99
I love the fact that this is the second edition, the first must have been a fucking runaway hit. I call it my log movie, and it features a crackling fire, optional Christmas carols, PLUS TWO BONUS outdoor campfires. It's atmosphere in a disc. I've used it for the holidays, I've used it on dates, I've used it when the heat busted in the Holly Lodge to psych myself into thinking it was warm in here. Every year I appreciate it just a little more. Thanks, log!
10. General Gluttony
I fed my face like it was Rome before the fall, and according to the scale at the gym, I didn't gain any weight! LOOKING at food usually makes me gain about 5lbs, so this is some kind of Christmas miracle. I had some amazing food, and that for me is pretty much the best way to celebrate the holidays. And? I got to see my mum, which always makes me happy. And friends. And cat. And log. And everything. I hope your holiday was just as awesome :)
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Counting box (boîte de jetons) with counters
French (Paris)
about 1750–70
Made by Mariaval, le jeune (French, active by 1746)
Overall: 1.9 x 8.3 x 5.7cm (3/4 x 3 1/4 x 2 1/4in.)
Accession Number
Medium or Technique
Painted ivory, gilt-metal, later leather case
Not On View
This is a set of four boxes was intended for the card game Quadrille, a variation on Ombre and Whist and involving bidding, trump suit, and taking tricks. The game called for four players, thereby requiring four boxes, one for each player and for each suit of cards. Each of the four boxes in this set is painted a different color–red, green, and yellow–or left in the natural color of the ivory. The lid of each is decorated with a suit of cards on an ivory disk, flanked by allegorical female figures painted en grisaille within roundels and representing the Four Seasons or the Elements. The top disk rotates on a center bronze pin, and a square opening in this disk reveals a number beneath. Painted on the underside of each lid is a pastoral landscape, depicting fishermen at a stream or figures greeting one another on a country path. These landscapes, painted en grisailles and touched with green, derive from Netherlandish engravings, which enjoyed a tremendous vogue in Paris during the third quarter of the 18th century. Inside each box remains the original painted ivory counting chips painted in the same color as the box and in three different shapes and sizes.
Red box (spades): 5 numerical counters (elongated octagons), 4 discs, 14 batons (slender rectangles).
White box (hearts): 4 numerical counters, 6 discs, 16 batons.
Green box (diamonds): 5 numerical counters, 2 discs, 16 batons.
Yellow box (clubs): 4 numerical counters, 5 discs, 14 batons.
Inscribed on the interior: "Mariaual le Jeune a Paris fecit"
André Chéronnet-Champollion (b. 1880 - d. 1915), Paris, New York, and Newport, NH [see note]; by inheritance to his son, René Chéronnet-Champollion (b. 1909 - d. 1959), New York and Newport, NH; by inheritance to his widow, Stella Champollion Trafford (b. 1912 - d. 2009), Boston; 2001, gift of Stella Champollion Trafford to the MFA. (Accession Date: April 25, 2001)
NOTE: He may have inherited this set of counting boxes (MFA accession nos. 2001.238.1-4) from his great-grandfather, Jean-François Champollion (b. 1790 - d. 1832).
Credit Line
Gift of Stella Champollion Trafford


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Cheyenne, Wyo. • A man who killed his father in front of a computer science class at a Wyoming community college was a "borderline genius" upset by the belief he had inherited Asperger's syndrome from his dad, an aunt of the killer said Monday.
Christopher Krumm, 25, blamed Asperger's for his trouble keeping jobs after he got a master's degree in electrical engineering from Colorado School of Mines in 2009, said Barbara Nichols, of Bakersfield, Calif.
"Nice to be around. Never caused any trouble of any kind," said Nichols, who'd briefly lived with her sister's family in Casper in the early 1990s.


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Stockport Beer Week
Thursday 21st September to Sunday 1st October 2017
¿Can't get your hands on a programme? Download a copy here.
Sorry but an error has crept through our proof reading of the programme!
In the introduction on page 3, the talk by Dr James Sumner's will not take place in the Hope. I will take place in the Railway, 74 Wellington Road North, SK4 1HF as correctly shown in the events sections.
Stockport Beer Week is back again for the third year. Coordinated by Stockport and South Manchester CAMRA, the event runs from 21st September to 1st October in conjunction with National Cask Ale Week.
There will be a full programme of events during the week, many of which are currently still being finalised. However already confirmed are the popular week-long Ale Trail, a Beer Festival at Robinson's Brewery Visitor Centre on 22nd & 23rd September and another Beer Festival at the Remedy Bar starting on 28th September to the end of the week.
Why not test your knowledge of the town at the Grand Stockport Quiz at the Spinning Top on Sunday 24th? Organised by Stockport County Supporters' Collective, it will cover the town's sporting connections as well as its pubs, heritage and music. The quiz will be followed by an evening of music by some of Stockport's most exciting bands.
There will also be pub cellar tours, a historic pub walk where you can learn about some the colourful history of Stockport's long lost pubs between Tiviot Dale and the Market Place and a heritage pub crawl visiting the three town centre pubs on the National Inventory of Historic Interiors. There will also be beer and cider tastings and meet the brewer evenings.
Watch a video of the Stockport Beer Week organiser at the press launch
September 21st - October 1st is #StockportBeerWeek, here's organiser Chris Walkden & Oliver Robinson from @robbiesbrewery to tell us more! pic.twitter.com/brILwmdjzh— Stockport LIVE (@Stockport_Live) 19 September 2017
All week events
Robinsons Visitor Centre
"Two for the price of one" on brewery tours. Only applies to pre-booked tours.
Book online here https://www.robinsonsbrewery.com/brewery-experience
Stockport Ale Trail
We have 20 pubs taking part on the trail, of which 12 must be visited, including (at least) 4 from the Robinsons estate, to claim your Stockport Beer Week t-shirt. Here is the full list of participating outlets:Robinsons
Arden Arms, Armoury, Bakers Vault, Blossoms, Queens, Red Bull, Robinsons Visitors Centre, Swan with Two Necks.Independants
Boars Head, Cocked Hat, Crown, Fairway, Hope, Magnet, Midland, Olde Vic, Petersgate Tap, Railway (Wellington Road North), Remedy Bar, Sun and Castle.
Full details, map and downloadable entry sheet here.
Thanks to Robinsons for sponsoring this event and contribution the commemorative t-shirt.
Thursday 21st September
Pub of the Month Presentation and Launch event
Starting at 8pm in the Petersgate Tap and including the unveiling of the Stockport Beer Week Beer specially brewed by Thirst Class Ales. What to know more about this and other Thirst Class Ales? then come along on Tuesday 26th September to meet the brewer.
Local Beer Festival at Calverts Court, 13 St Petersgate SK1 1EB - starts 6pm and runs until Sunday (unless the beer runs out beforehand!) but closes at 12midnight today.
Join our own Wetherspoons as they hold their very first festival of local and special beers. Expect an extra stillage of barrels as well as the usual hand-pumps on the bar.
Friday 22nd September
Robinsons Brewery Visitors Centre Beer Festival
Apsley Street, SK1 1YE .Open 3pm - 11pm. £5 entry (£4 in advance). CAMRA members £4 on the door on production of current membership card. Advance tickets from the brewery 0161 612 4100 or firstname.lastname@example.com.
20+ beers including many from local breweries and cider too. Music from 6.30pm
Entrance price includes a souvenir glass. If you don't want to keep the glass, you can claim £1 refund on returning the glass in good condition. Token system for beer purchases. Food available.
Download the beer list HERE.
Local Beer Festival at Calverts Court, 13 St Petersgate SK1 1EB, all day from 9am to 1am.
Stop press - Wetherspoons Beer Festival
Now starting Wednesday 27th and running until Sunday 1st October
Historic Pubs Walk - Tiviot to Market Place
Starts at 7pm and is planned to finish at 8pm. Meet at Lancashire Bridge, Bridge Street, SK1 1XU outside Barclays Bank. No booking required. Charge £1 - payable on the night.
Led by one of Stockport's leading historians, this popular walk follows a different route to last year. Learn about some of the pubs of Old Stockport - and afterwards why not enjoy some of them that still exist on the Heritage Pub Crawl?
Heritage Pub StaggerVisit three Stockports pubs with historic and architectural interiors. Starts at 8.30pm in the Swan with Two Necks on Prince's Street (approximatly opposite Marks & Spencers), continues with the Queen's Head/Turners Vaults (Underbank beneath the Petersgate bridge) at approx. 9.15pm and finishing at the Arden Arms (behind ASDA on New Bridge Lane) at an estimated 10pm.
Saturday 23rd September
Local Beer Festival at Calverts Court, 13 St Petersgate SK1 1EB, all day from 9am to 1am.
Stop press - Wetherspoons Beer Festival
Now starting Wednesday 27th and running until Sunday 1st October
Robinsons Brewery Visitors Centre Beer Festival
Apsley Street, SK1 1YE .Open 11am - 11pm. £5 entry (£4 in advance). CAMRA members £4 on the door on production of current membership card. Advance tickets from the brewery 0161 612 4100 or email@example.com.
20+ beers including many from local breweries and cider too. Music from 1pm
Entrance price includes a souvenir glass. If you don't want to keep the glass, you can claim £1 refund on returning the glass in good condition. Token system for beer purchases. Food available.
Market Place Cellar Tours
Duration approx 30 minutes. No booking required, just turn up (subject to space). No charge.
* NOTE - All cellar tours are at own risk and involve climbing stairs and some low ceilings. Although the lighting is mostly good, participants may wish to bring a torch.
Two tours of the Boars Head, 2 Vernon Street, Market Place, SK1 1TY at 12:00 noon and 1:15pm.
This Samuel Smith's pub is a friendly community pub on the Market Place. It only serves one cask beer, Samuel Smith's Old Brewery Bitter, which comes in large wooden barrels and is always in excellent condition. Have a look at what goes on in the cellar of a good working pub.
Two tours of the Bakers Vaults, Market Place at 12:30pm and 1:45pm.
The Baker's Vaults was reinvigorated by a thorough refurbishment in mid-2014. Although a single, large room, it is an architecturally impressive space, rebuilt in the late 19th C in the 'gin palace' style. The site is on the foundations of the old Stockport Castle and during the refurbishment various tunnels were discovered in the cellar.
Sunday 24th September
Robinsons Brewery Visitors Centre Beer Festival
Apsley Street, SK1 1YE . Only if there is any beer left. Open 10:30am - 4pm. Admission Free. If there are any festival beers left, Robinsons will be selling them off as well as having beers on the normal visitor centre bar.
Stockport Quiz & Music Evening
Spinning Top, 20 Wellington Road South, SK4 1AA - How well do you know Stockport? Take part in the Stockport County Supporters' Co-operative Quiz between 5:30pm and 7:30pm followed by music form local musicians in the evening.
£2 a head entry to the Quiz with a maximum team size of 5, but individuals can also have a go. And it's free to spectate! Think you know about your local town? Why not prove it and win some beer to boot! All questions are about places, people and events connected with the town, and will cover areas such as Local Knowledge, History, Entertainment, Famous Stopfordians & Local Sport with a picture round on the town's pubs. Even though this event is raising funds for the Stockport County Supporters' Co-operative, don't panic; not all the sport questions will be about football! Local beers and ciders will be featured and hot food will be available from 7pm @ £2 a plate.
Long-time County Supporter Lee Renshaw will be playing acoustic Britpop covers from 8pm to help you wind down after your efforts! Please note that the main road outside the venue is closed for major works. However, pedestrian access is maintained.
Monday 25th September
Historic Beer Talk - CHEMISTS, DRUGGISTS AND BEER DOCTORS
given by Dr James Sumner at the Railway, 74 Wellington Road North, SK4 1HF, starts 7:30pm. Approximately 1 hour duration. Admission free.
And now for something new and completely different in this great community pub on the Slope! Brewery historian Dr James Sumner from the University of Manchester will take us through the stranger practices of 19th century beer making with a live demonstration of the old-style art of the 'beer doctors'. Chemical additives were a widespread feature of 19th century brewing. Heralded as great innovations by brewers, they were viewed with suspicion by drinkers who saw the traditional goodness of malt and hops under threat. And while panics about fatal poisonings scared the public and tax-dodging worried the authorities, the courts were faced with the question of whether it is right to brew with stinking fish. A fascinating evening is in prospect; please do join us.
Tuesday 26th September
Watch the Brewer
Remedy Bar & Brewhouse, 10-11 Market Place, SK1 1EW. Watch the brewer carry out the brewing of a beer from 12 noon.
Today, Mark will be brewing up one of his delicious beers and you can watch some of the process for yourselves. Brewing will have started before the bar opens but there will still be plenty to watch. At certain times Mark will be coming out of the brewery and you can ask questions, but as many of the processes are time critical, he might have to rush off again! Meanwhile why not sample "one he made earlier" or one of the unusual guest beers whilst you watch what happens. And you can enjoy a spot of lunch until 2.30pm.
Meet the Brewer
Meet Colin from Poynton Brewery at the Spinning Top, 20 Wellington Road South, SK4 1AA from 7:00pm to 8:15pm
Poynton Brewery are based at the Royal British Legion in the village and were set up in late 2015 when the current owners took over the plant of the defunct Worth Brewery. Since then their beers have become widely available in the local area and include one named after that most famous of local products, the Avro Vulcan. The Spinning Top is a regular outlet for their beers and tonight you can try their new ale called Viaduct, which is their first golden ale (4% ABV). This will be available at The Spinning Top for the duration of Stockport Beer Week.
Please note that the main road outside the venue is closed for major works. However, pedestrian access is maintained.
Meet the Brewer
Meet with Richard from Thirst Class and including a talk about the setting up of a Micro Pub business by Alan Gent in the Petersgate Tap, 19a Petersgate, SK1 1EB. Starts 8:30pm
Richard is the owner and brewer of Thirst Class Ales based in Reddish. He started brewing commercially on a small scale in 2014 and went full-time at the beginning of 2016 when the opportunity arose to take over the premises previously occupied by Ringway Brewing. His beers are frequently noted in Stockport and around the North West and he has already won several awards.
Alan Gent, the owner of the venue, will also tell us about the trials and tribulations of opening a micro pub.
Wedesday 27th September
Staircase House Beer Tour
Staircase House, 30/31 Market Place, SK1 1ES. Starts at 7:00pm Booking essential. Cost £5 (£3 for CAMRA members). To book call 0161 474 4444.
Staircase House is a beautifully restored 15th century townhouse situated in Stockport's historic Market Place. It is home to one of only three surviving Jacobean cage-newel staircases in the country. In this special tour, learn about the past of Stockport's oldest town house and discover how our ancestors lived from the 15th to the 20th centuries with an emphasis on the beer offerings of the time. Get to see areas that are usually off limits and one area that is thought to be an ancient Brewhouse.
Wetherspoons - Revised times
Wetherspoons - Revised times
Local Beer Festival at Calverts Court, 13 St Petersgate SK1 1EB, all day from 9am to 1am.
Now starting Wednesday 27th and running until Sunday 1st October
Thursday 28th September
Meet the Brewers
Yes brewers! Martin and Katie share the brewing at the Fool Hardy Brewers based in the Hope, 118 Wellington Road North, SK4 2LL. Starts at 8:00pm.
Martin started the Hope's very own micro-brewery, 'Fool Hardy Ales' in 2013 shortly after he and his good lady Sam had purchased the pub. The name Fool Hardy is nod to the past history of the Hope which started life as a Hardy�s Crown Ales brewery house. There are always six of their ales on the pumps - look out for the distinctive pump clips designed by Martin himself - as well as a selection of guest ales. In addition, Fool Hardy Riptide was voted Beer of the Festival at Stockport this year. In 2016, Martin took on Katie Bromley as assistant brewer and she has developed her own Shmatie Signature series of beers where all the beer names are palindromes. Her special beer to be launched this evening is an I.P.A. at 5% and called "Oozy rat in a sanitary zoo". Is this the quirkiest name ever for a beer? Come along, be one of the first to try it and meet the team that makes it happen at this excellent pub.
Remedy Bar Beer Festival
Remedy Bar & Brewhouse, 10-11 Market Place, SK1 1EW from noon until 11pm.
Following a successful beer festival at Easter 2017, the bar is repeating the exercise. As well as the 6 hand-pumps expect a stillage featuring around 20 local beers of lots of different styles, so there's bound to be something to tickle your taste buds. And why not try one of their own beers brewed behind the glass wall in the bar?
Friday 29th September
Remedy Bar Beer Festival
In house festival at this Market Place pub. See Thursday 28th for detail.
Foodie FridayMarket Place, Stockport, admission Free
Held on the last Friday of every month, it's a continental street caf7eacute; culture which appeals to all ages and there are plenty of food stalls and a beer shop in the Market Hall to enjoy. And there's now a plan to create a popular permanent social space for the local community in the Produce Hall by providing the perfect mix of independent street food, ales, live music and entertainment. Why not seek out the CAMRA stand where you can learn about the organisation locally and buy raffle tickets from our charity partner SCP? Afterwards the pubs remain busy, but they are all on the Ale Trail, so why not call in, buy a beer and get a stamp?
Saturday 30th September
Staircase House Beer Tour
Staircase House, 30/31 Market Place, SK1 1ES. Starts at 2:00pm Booking essential. Cost £5 (£3 for CAMRA members). To book call 0161 474 4444.
Tutored Belgian Beer Tasting
With John Clarke and taking place in Staircase House, 30/31 Market Place, SK1 1ES. Starts at 3:30pm.
Booking advised - Tickets £12. Cost includes beer. To book call 0161 474 4444. There may be some tickets available on the door on the day.
Local CAMRA activist and expert on Belgian beers, John Clarke will guide you through a tasting of some of Belgium's finest in the magnificent surroundings of Stockport's oldest townhouse.
Remedy Bar Beer Festival
In house festival at this Market Place pub. For other details, see entry under Thursday 28th September
Presentation - Best Mild Pub
CAMRA presentation award for the best Mild pub on the Mild Magic trail to the Remedy Bar & Brewhouse, 10-11 Market Place, SK1 1EW. Starts at 7:30pm.
Sunday 1st October
Tutored Cider and Perry Tasting
Tutored cider and perry tasting and meet the cider producers at the Petersgate Tap, 9a Petersgate, SK1 1EB. Starts 2:00pm.
Tickets £12 - Tickets in advance can be bought at the Petersgate Tap, by post or on the door on the day subject to space available. You can also e-mail them on firstname.lastname@example.com Price includes nine 1/3rds of different cider/perries and some cheese & biscuits. Postal tickets can be bought by sending a cheque to the address above and then either be picked up at the venue or they will post them out if required.
It's that man again! John Clarke also is an expert on cider and perry and will guide you through a tasting of nine ciders and perries, some of them local. Yes that's right - cider doesn't just come from Herefordshire or the West Country. In Stockport and the North West, we have some fine producers and as part of the afternoon, some of them will be in attendance. You can find out more about the process whilst sampling the products. After the tasting there will be an opportunity to buy more cider at the special price of £3 a pint.
Remedy Bar Beer Festival
In house festival at this Market Place pub. For other details, see entry under Thursday 28th September
Woodstockport Music Festival
Spinning Top, 20 Wellington Road South, SK4 1AA. From 4:00pm.
The Beer Week concludes with an evening of local bands at the Spinning Top in conjunction with Stockport County Supporters' Co-operative (SCSC) and 10% of takings will go to them. It is hoped to feature bands such as Mutha Lovin Chimps, Exit 7, Smashing Lads & Ten Eyed Man (all tbc) from 4pm onwards. Food will be available and as it just happens to be the 50th birthday party of the landlord, Mike Swann, it should be a great evening that will ensure the Week ends on a high note...
Please note that the main road outside the venue is closed for major works. However, pedestrian access is maintained.


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[1] Spiller, Gene A. (1998). Caffeine. Boca Raton: CRC Press. ISBN 0-8493-2647-8.
[2] Sobal J, Marquart LF. Vitamin/mineral supplement use among athletes: a review of the literature. Int J Sports Nutr. 1994;4:320–34.
[3] Nesheim MC. What is the research base for use of dietary supplements? Public Health Nutr. 1999;2:35–8.
[4] Hoffman JR, et al. (2008). Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutrition Research (New York, N.Y.). 28(1), 31-5.
[5] Folin, Otto; Denis, W (1912). "Protein metabolism from the standpoint of blood and tissue analysis". Journal of Biological Chemistry 12 (1): 141–61.
[6] Birch R, Noble D, Greenhaff PL:The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. European journal of applied physiology and occupational physiology 1994, 69(3):268-276.
[7] Gold, P.W. and Chrousos, G.P. (2002). Organisation of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatr. 7:254-275.
[8] 6) Lee, S., et al. (2007). Schizandra chinensis and Scutellaria baicalensis counter stress behaviors in mice. Phytotherapy Reaearch. DOI. 10.1002/ptr. 2233
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You must register to post or download hacks.
If you are having any issues, shoot us an email, Contact MPGH Support.
As always, have fun and enjoy your stay!
- MPGH Staff
Originally Posted by Raster Burn
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O2 Binding to Heme is Strongly Facilitated by Near-Degeneracy of Electronic States
This paper reports the computed O2 binding to heme, which for the first time explains experimental enthalpies for this process of central importance to bioinorganic chemistry. All four spin states along the relaxed FeO2-binding curves were optimized using the full heme system with dispersion, thermodynamic, and scalar-relativistic corrections, applying several density functionals. When including all these physical terms, the experimental enthalpy of O2 binding (−59 kJ mol−1) is closely reproduced by TPSSh-D3 (−66 kJ mol−1). Dispersion changes the potential energy surfaces and leads to the correct electronic singlet and heptet states for bound and dissociated O2. The experimental activation enthalpy of dissociation (∼82 kJ mol−1) was also accurately computed (∼75 kJ mol−1) with an actual barrier height of ∼60 kJ mol−1 plus a vibrational component of ∼10 and ∼5 kJ mol−1 due to the spin-forbidden nature of the process, explaining the experimentally observed difference of ∼20 kJ mol−1 in enthalpies of binding and activation. Most importantly, the work shows how the nearly degenerate singlet and triplet states increase crossover probability up to ∼0.5 and accelerate binding by ∼100 times, explaining why the spin-forbidden binding of O2 to heme, so fundamental to higher life forms, is fast and reversible.


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that you're furniture just can't fit. Where there is a will, there's a way, and we are
experts in furniture hoisting. If there is a window, door, or porch, we can help get
those stubborn pieces into your new home. (Additional charges apply)
Moving Supplies
We can Also supply you with any moving materials you may need, including, but not limited to:
- New and Used Boxes
- Packing Tape
- Bubble Wrap
- Mattress Bags
- Shrink Wrap
We also bring our own furniture pads, straps, and dollies to keep your belongings safe throughout the move.