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Agility—the ability to move quickly and easily—should characterize U. The system concept of NAVSPASUR is that of a continuous wave (CW) multistatic radar. The Army is also charged with providing logistics and support to enable the other Services to accomplish their missions, and supporting civil authorities in time of emergency, when directed. The United Nations also has it's talons in the whole global warming scam and their green movement has always been a militaristic front for global sustainability and how the elite can survive an extinction level threat.
Pages: 129
Publisher: Plutoid Press (November 12, 2013)
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- Vladimir Borschev, Barbara H. Partee, +19 authors Tanya Yanko
- 2001
our gratitude does not imply their agreement with our conclusions, for which we take full responsibility. We are also grateful to audiences and conference co-participants at FASL 6, the " Bridges and
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The two goals of this paper are (i) to establish that there are comparative correlatives that are not comparative conditionals and that the semantics of such correlatives crucially involves a relation (possibly the identity relation) between differentials (against much of the previous literature, e.g., McCawley 1988, Beck 1997) and (ii) to argue that a… (More)
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Atkinson (Reports, 15 April 2011, p. 346) concluded that language originated in western Africa and that, due to a serial founder effect, languages repeatedly lost phonemes the farther they moved from the African point of origin. Independent examination of the published data tends to refute both these claims.
0. Proposal. A central debate in the study of phrase structure concerns the nature of functional projections which dominate lexical ones. At one extreme is the position, advocated by Cinque (1999, 2002), that grammars employ a universal set of functional categories and that their number and relative order is the same across languages, regardless of… (More)
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Three constructions of English are under scrutiny: in the first, the post-verbal noun (PVN) is a Cognate Object (CO, e.g. They all sighed a little sigh of relief); in the second, it is a Reaction Object (RO, e.g. She rattled out a painful laugh), whilst in the third it is a Measure Phrase (MP, e.g. This case weighs 20 kilos). COs, ROs, and MPs are analysed… (More)
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Rachel Alexandra back in training
LOUISVILLE, Ky. - Rachel Alexandra, the superstar filly who has been taking it easy on the Churchill Downs backstretch for the last seven weeks, has returned to the racetrack for the first time since arriving here Oct. 7 from Saratoga.
Owned primarily by the Stonestreet Stables of Jess Jackson and trained by Steve Asmussen, Rachel Alexandra jogged a very easy mile Monday and Tuesday, both times going late in the morning when traffic is very light on the main track.
"She was ready to get out there and do something, finally," said assistant trainer Scott Blasi. "She's put on a lot of weight, looks beautiful, traveling great. We just wanted to get her back out there a few days because she's so familiar and comfortable with the track here at Churchill."
Blasi said Rachel Alexandra will ship to Fair Grounds in New Orleans after the Churchill meet concludes on Saturday, "although we haven't made a final decision on exactly what day."
Jackson and Asmussen have said they intend to race Rachel Alexandra as a 4-year-old, with a more serious training regimen to begin sometime after she arrives at Fair Grounds, where Asmussen's top horses are stabled every winter.
Tuesday morning, with Dominic Terry up and while accompanied by a stable pony ridden by Blasi, Rachel Alexandra came out onto the 5 1/2-furlong gap Tuesday at about 9:30 a.m. She proceeded to jog once around the one-mile track, staying on the outer perimeter until exiting the same gap she entered. Blasi said the filly likely will continue to have the same sort of easy training schedule until leaving here.
Rachel Alexandra had done little more than graze and stand in her stall until about 10 days ago, when she began walking under tack on the shed row each morning.
Rachel Alexandra won all eight of her races this year and is the subject of tremendous debate about whether she or Zenyatta deserves the 2009 Horse of the Year Award, which will be announced Jan. 18 at the annual Eclipse Awards dinner in Beverly Hills, Calif.
Rachel Alexandra defeated male rivals three times this year in winning the Preakness, Haskell Invitational, and Woodward Stakes. Following her last start of the year, the Sept. 5 Woodward at Saratoga, she remained stabled at Saratoga until shipping to Churchill.


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Executive Compensation Committee
Executive Compensation Committee Charter
The purpose of the Executive Compensation Committee (the "Committee") is to discharge the Board's responsibilities relating to compensation of the Corporation's executives, to produce an annual report on executive compensation for inclusion in the Corporation's annual proxy statement, and to oversee and advise the Board on the adoption of policies that govern the Corporation's compensation programs, including stock and benefit plans.
Committee Membership
The Committee shall be comprised of at least two members. All Committee members shall be independent of management and free of any relationship that, in the opinion of the Board of Directors would interfere with the exercise of independent judgment. Independence shall be determined in accordance with the director independence standards established by the New York Stock Exchange and Securities and Exchange Commission in effect from time to time.
The members of the Committee shall be appointed by the Board of Directors, at the Board's annual meeting, on the recommendation of the Committee, and may be removed by the Board at any time. Unless a chairman is elected by the full Board, the members of the Committee shall designate a Chairman by majority vote of the full Committee membership.
Committee Meetings & Reporting
The Committee shall meet as often as may be deemed necessary or appropriate in its judgment, but at least twice per year. Additional meetings may occur as the Chairman or the majority of the Committee deems advisable. The Committee shall keep minutes of all its meetings. The Committee shall report to the Board of Directors on its meetings and discussions at Board meetings.
Responsibilities and Duties
To fulfill its purpose, the Committee shall:
1. Review and approve annually corporate goals and objectives relevant to CEO compensation and evaluate the CEO's performance in light of those goals and objectives.
2. Based on the foregoing evaluation, the Committee shall, either as a committee or together with the other independent directors (as directed by the Board), determine and approve the CEO's compensation level (including base salary level, incentive compensation and equity-based compensation). In determining the long-term incentive component of the CEO's compensation, the Committee shall consider Tredegar's performance and relative shareholder return, the value of similar incentive awards to CEOs at comparable companies and the awards given to the CEO in past years.
3. Review and approve the compensation level of all other officers of the Corporation, including base salary level, incentive compensation and equity-based compensation.
4. Review and approve (or, where appropriate, recommend to the Board) incentive-compensation plans and equity-based plans that include the CEO and other officers of the Corporation.
5. Produce an annual report on executive compensation for inclusion in the Corporation's annual proxy statement, in accordance with applicable rules and regulations.
6. Have sole authority to retain and terminate any compensation consultant that may be used to assist in the evaluation of CEO or senior executive compensation; sole authority to approve the consultant's fees and other retention terms.
7. Perform such other duties and functions as may be requested by the Board.
The performance of any of these responsibilities may be delegated to a subcommittee of the Committee created and approved by the Committee. Any such subcommittee must be composed entirely of independent directors and must have a published committee charter.
Annual Performance Evaluation; Annual Charter Review
The Committee shall conduct an annual self-evaluation of the Committee's performance and report its findings to the Board of Directors.
The Committee shall review and reassess this Charter at least annually and recommend any proposed changes to the Nominating and Governance Committee for approval.
The Committee shall perform such other duties and functions as may be assigned by Tredegar's Board of Directors.
To the extent that any provision or section of this Charter may be inconsistent with any article, provision or section of Tredegar's Articles of Incorporation, the Bylaws or any applicable law or regulation, the Articles of Incorporation, the Bylaws or the law or regulation, as appropriate, shall control.
Nothing in this Charter is to be construed as precluding discussion of CEO compensation with the Board generally.


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Recent Research Articles from UNTHSC
Recent research articles indexed in PubMed from authors affiliated with the UNT Health Science Center.
"Curcumin-loaded Poly (d, l-lactide-co-glycolide) nanovesicles induce antinociceptive effects and reduce pronociceptive cytokine and BDNF release in spinal cord after acute administration in mice".
"Curcumin-loaded Poly (d, l-lactide-co-glycolide) nanovesicles induce antinociceptive effects and reduce pronociceptive cytokine and BDNF release in spinal cord after acute administration in mice".
Colloids Surf B Biointerfaces. 2017 Jul 10;158:379-386
Authors: Pieretti S, Ranjan AP, Di Giannuario A, Mukerjee A, Marzoli F, Di Giovannandrea R, Vishwanatha JK
Given the poor bioavailability of curcumin, its antinociceptive effects are produced after chronic intravenous administration of high doses, while poly (d,l-lactide-co-glycolide)-loaded vesicles (PLGA) can improve drug delivery. This paper investigates the antinociceptive effects of curcumin-loaded PLGA nanovesicles (PLGA-CUR) administered via intravenous (i.v.) or intrathecal (i.t.) routes at low and high doses. The following models of pain were used: formalin test, zymosan-induced hyperalgesia and sciatic nerve ligation inducing neuropathic allodynia and hyperalgesia. PLGA-CUR administered intravenously was able to reduce the response to nociceptive stimuli in the formalin test and hyperalgesia induced by zymosan. Curcumin, instead, was inactive. Low-dose i.t. administration of PLGA-CUR significantly reduced allodynia produced by sciatic nerve ligation, whereas low doses of curcumin did not change the response to nociceptive stimuli. Long-lasting antinociceptive effects were observed when high doses of PLGA-CUR were administered intrathecally. At high doses, i.t. administration of curcumin only exerted rapid and transient antinociceptive effects. Measurement of cytokine and BDNF in the spinal cord of neuropathic mice demonstrate that the antinociceptive effects of PLGA-CUR depend on the reduction in cytokine release and BDNF in the spinal cord. The results demonstrate the effectiveness of PLGA-CUR and suggest that PLGA-CUR nanoformulation might be a new potential drug in the treatment of pain.
PMID: 28719859 [PubMed - as supplied by publisher]
Undiagnosed Liver Fibrosis in Patients Undergoing Pancreatoduodenectomy for Pancreatic Adenocarcinoma.
Undiagnosed Liver Fibrosis in Patients Undergoing Pancreatoduodenectomy for Pancreatic Adenocarcinoma.
World J Surg. 2017 Jul 17;:
Authors: Gdowski A, Osman H, Butt U, Foster S, Jeyarajah DR
BACKGROUND: Chronic obstruction of the biliary system may cause hepatic fibrosis and liver failure. The purpose of this study was to define the incidence of unrecognized liver fibrosis in patients undergoing pancreaticoduodenectomy (PD).
METHODS: Retrospective data were collected on patients undergoing PD during a 21-month period. Each patient had a core needle biopsy at the time of surgery by a hepatobiliary surgeon.
RESULTS: This study identified 36 consecutive patients who were referred to a tertiary center and underwent pancreatoduodenectomy during a period of 21 months. The majority of patients, 32 (88.8%), were diagnosed with pancreatic adenocarcinoma. Liver fibrosis was diagnosed in 23 (63.9%) patients. A total of 25 (69.4%) patients were found to have pathological evidence of cholestasis consistent with bile obstruction. Patients that were found to have evidence of obstruction had significantly increased odds that fibrosis stage 2 would be found on pathological diagnosis (OR 6.75, 95% CI 1.20-38.02, Fisher's exact test P value = 0.0312). There was no significant association in patients who were stented compared to non-stented patients and their diagnosis of high-grade fibrosis stage 2 (OR 1.5238, 95% CI 0.4019-5.7769, Fisher's exact test P value = 0.7360).
CONCLUSIONS: An astonishing 63.9% of patients who underwent PD were diagnosed with stage 1-4 liver fibrosis and half (47.2%) had fibrosis stage of 2 or more. Further, stent status had no significant impact on the degree of liver fibrosis. Liver fibrosis is currently underrecognized in patients undergoing PD, which is important for physicians to be conscious of as it is known that liver fibrosis increases morbidity and mortality.
PMID: 28717906 [PubMed - as supplied by publisher]
Systematic review of comparative effectiveness and health economics research relating to osteopathic manipulative treatment.
Systematic review of comparative effectiveness and health economics research relating to osteopathic manipulative treatment.
Musculoskelet Sci Pract. 2017 Jun;29:e16-e17
Authors: Licciardone JC
PMID: 28715303 [PubMed - in process]
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
Nat Genet. 2017 Jul 17;:
Authors: Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, Bullido MJ, Hofman A, Montine TJ, Coto E, Boerwinkle E, Petersen RC, Alvarez V, Rivadeneira F, Reiman EM, Gallo M, O'Donnell CJ, Reisch JS, Bruni AC, Royall DR, Dichgans M, Sano M, Galimberti D, St George-Hyslop P, Scarpini E, Tsuang DW, Mancuso M, Bonuccelli U, Winslow AR, Daniele A, Wu CK, GERAD/PERADES, CHARGE, ADGC, EADI, Peters O, Nacmias B, Riemenschneider M, Heun R, Brayne C, Rubinsztein DC, Bras J, Guerreiro R, Al-Chalabi A, Shaw CE, Collinge J, Mann D, Tsolaki M, Clarimón J, Sussams R, Lovestone S, O'Donovan MC, Owen MJ, Behrens TW, Mead S, Goate AM, Uitterlinden AG, Holmes C, Cruchaga C, Ingelsson M, Bennett DA, Powell J, Golde TE, Graff C, De Jager PL, Morgan K, Ertekin-Taner N, Combarros O, Psaty BM, Passmore P, Younkin SG, Berr C, Gudnason V, Rujescu D, Dickson DW, Dartigues JF, DeStefano AL, Ortega-Cubero S, Hakonarson H, Campion D, Boada M, Kauwe JK, Farrer LA, Van Broeckhoven C, Ikram MA, Jones L, Haines JL, Tzourio C, Launer LJ, Escott-Price V, Mayeux R, Deleuze JF, Amin N, Holmans PA, Pericak-Vance MA, Amouyel P, van Duijn CM, Ramirez A, Wang LS, Lambert JC, Seshadri S, Williams J, Schellenberg GD
We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10(-4)) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10(-8)) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10(-10), odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10(-10), OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10(-14), OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease.
PMID: 28714976 [PubMed - as supplied by publisher]
Expansion of Microbial Forensics.
Expansion of Microbial Forensics.
J Clin Microbiol. 2016 Aug;54(8):1964-74
Authors: Schmedes SE, Sajantila A, Budowle B
Microbial forensics has been defined as the discipline of applying scientific methods to the analysis of evidence related to bioterrorism, biocrimes, hoaxes, or the accidental release of a biological agent or toxin for attribution purposes. Over the past 15 years, technology, particularly massively parallel sequencing, and bioinformatics advances now allow the characterization of microorganisms for a variety of human forensic applications, such as human identification, body fluid characterization, postmortem interval estimation, and biocrimes involving tracking of infectious agents. Thus, microbial forensics should be more broadly described as the discipline of applying scientific methods to the analysis of microbial evidence in criminal and civil cases for investigative purposes.
PMID: 26912746 [PubMed - indexed for MEDLINE]
Hookah use among adolescents: Differential cognitions about hookah and cigarettes.
Hookah use among adolescents: Differential cognitions about hookah and cigarettes.
Addict Behav. 2017 Jul 09;75:75-78
Authors: Barnett TE, Livingston MD
Background Hookah use is prevalent among adolescent and young adult populations. The study assessed how positive cognitions toward cigarettes moderate the impact of positive hookah cognitions on past 30day hookah use among a representative sample of youth. Understanding cognitions about products can contribute to effective interventions. Methods Data from the 2015 Florida Youth Tobacco Survey was used to determine cognitions and use patterns among high school students. Weighted means and proportions were used for demographic comparisons for cognitions about products. t-Tests and chi-square analysis were conducted for differences between users and non-users. Logistic regressions were conducted for the modeling of interaction between hookah and cigarette cognition. Results Nearly one out of ten (9.6%) of adolescents reported current hookah use. Across all cognition measures, positive hookah cognitions were associated with current hookah use. Additionally, there was a pattern of hookah cognitions being more strongly associated with current hookah use among those students that did not endorse the equivalent cognition for traditional cigarettes. Conclusions Hookah cognitions were generally more associated with hookah use among youth who did not endorse positive cognitions for cigarettes compared to those that did endorse positive cognitions for cigarettes. This finding is novel given youth who feel negatively about cigarettes are more influenced by their hookah-specific cognitions. Youth who believe cigarettes pose harm may benefit from messaging about the harms of hookah. Interventions or prevention efforts that draw strong comparisons between cigarettes and hookah may be effective among youth.
PMID: 28711747 [PubMed - as supplied by publisher]
Association between thyroid dysfunction and dysglycaemia: a prospective cohort study.
Association between thyroid dysfunction and dysglycaemia: a prospective cohort study.
Diabet Med. 2017 Jul 14;:
Authors: Chang CH, Yeh YC, Shih SR, Lin JW, Chuang LM, Caffrey JL, Tu YK
AIMS: To compare the incidence of hyperglycaemia among participants with low, elevated and normal serum thyroid-stimulating hormone concentration, as well as the incidence of abnormal thyroid function test results among participants with normal blood glucose and those with hyperglycaemia.
METHODS: In a prospective study, a cohort of 72 003 participants with normal, low and elevated serum thyroid-stimulating hormone concentration were followed from the study beginning to the first report of diabetes and prediabetes. A proportional hazards regression model was used to calculate the hazard ratios and 95% CIs for each outcome, adjusting for age, sex, education level, smoking, alcohol consumption and obesity. Analyses for the association between dysglycaemia and incident abnormal thyroid function test were also conducted.
RESULTS: During a median 2.6 year follow-up, the incident rates for dysglycaemia, particularly prediabetes, were substantially higher in participants with elevated thyroid-stimulating hormone concentrations at baseline, while the rates for participants with normal and low thyroid-stimulating hormone were similar. After controlling for risk factors, participants with elevated thyroid-stimulating hormone retained a 15% increase in risk of prediabetes (adjusted hazard ratio 1.16, 95% CI 1.05-1.28), but were not at greater risk of diabetes (adjusted hazard ratio 1.04, 95% CI 0.68-1.52). By contrast, participants with normal and low thyroid-stimulating hormone concentrations had similar dysglycaemia risks. Participants with diabetes and prediabetes were not at greater risks of developing abnormal thyroid function test results when compared with participants with euglycaemia.
CONCLUSIONS: People with elevated serum thyroid-stimulating hormone concentration are at greater risk of developing prediabetes. Whether this includes a greater risk of developing frank diabetes may require an extended period of follow-up to clarify. This article is protected by copyright. All rights reserved.
PMID: 28710779 [PubMed - as supplied by publisher]
Short-Term Alcohol Abstinence Improves Antibacterial Defenses of Chronic Alcohol-Consuming Mice against Gut Bacteria-Associated Sepsis Caused by Enterococcus faecalis Oral Infection.
Short-Term Alcohol Abstinence Improves Antibacterial Defenses of Chronic Alcohol-Consuming Mice against Gut Bacteria-Associated Sepsis Caused by Enterococcus faecalis Oral Infection.
Am J Pathol. 2017 Jul 11;:
Authors: Kobayashi M, Asai A, Ito I, Suzuki S, Higuchi K, Suzuki F
The effects of short-term alcohol abstinence on host antibacterial resistance against Enterococcus faecalis oral infection was investigated in chronic alcohol-consuming mice [mice with 0.1 g/day of 20% ethanol consumption for 12 or 16 weeks (CAC-mice)]. These mice were highly susceptible to the infection; however, after 7 days of alcohol abstinence (aaCAC-mice), their antibacterial resistances were completely restored to the normal mouse level. Normal mice inoculated with CAC-mouse hepatic macrophages were shown to be susceptible to the infection, whereas the same macrophage preparation from aaCAC-mice did not impair the antibacterial resistance of normal mice. aaCAC-mouse liver macrophages protected nonobese diabetic-severe combined immunodeficiency IL-2Rγ(null) mice exposed to E. faecalis, whereas those from CAC-mice did not. Monocyte-derived (MD) M2b macrophages were predominantly isolated from CAC-mouse livers, but these cells were not significantly isolated from aaCAC-mouse livers. Hepatic MD macrophages from aaCAC-mice switched to M1 macrophages in response to bacterial antigen, whereas the same macrophage preparation from CAC-mice did not. M1 Kupffer cells, M2a Kupffer cells, and MD M2b macrophages were shown to be not bactericidal, whereas E. faecalis was killed effectively by M1 macrophages derived from aaCAC-mouse hepatic MD macrophages. These results indicate that MD M2b macrophages predominantly distributed in the liver are responsible for the impaired resistance of CAC-mice to E. faecalis oral infection, and aaCAC-mice without MD M2b macrophages in the livers are resistant to the infection.
PMID: 28708971 [PubMed - as supplied by publisher]
Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine.
Dysregulated corticostriatal activity in open-field behavior and the head-twitch response induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine.
Neuropharmacology. 2017 Feb;113(Pt A):502-510
Authors: Rangel-Barajas C, Estrada-Sánchez AM, Barton SJ, Luedtke RR, Rebec GV
The substituted amphetamine, 2,5-dimethoxy-4-iodoamphetamine (DOI), is a hallucinogen that has been used to model a variety of psychiatric conditions. Here, we studied the effect of DOI on neural activity recorded simultaneously in the primary motor cortex (M1) and dorsal striatum of freely behaving FvB/N mice. DOI significantly decreased the firing rate of individually isolated neurons in M1 and dorsal striatum relative to pre-drug baseline. It also induced a bursting pattern of activity by increasing both the number of spikes within a burst and burst duration. In addition, DOI increased coincident firing between simultaneously recorded neuron pairs within the striatum and between M1 and dorsal striatum. Local field potential (LFP) activity also increased in coherence between M1 and dorsal striatum after DOI in the low frequency gamma band (30-50 Hz), while corticostriatal coherence in delta, theta, alpha, and beta activity decreased. We also assessed corticostriatal LFP activity in relation to the DOI-induced head-twitch response (HTR), a readily identifiable behavior used to assess potential treatments for the conditions it models. The HTR was associated with increased delta and decreased theta power in both M1 and dorsal striatum. Together, our results suggest that DOI dysregulates corticostriatal communication and that the HTR is associated with this dysregulation.
PMID: 27816502 [PubMed - indexed for MEDLINE]
5-(N, N-Hexamethylene) amiloride is a GABA-A ρ1 receptor positive allosteric modulator.
5-(N, N-Hexamethylene) amiloride is a GABA-A ρ1 receptor positive allosteric modulator.
Channels (Austin). 2016 Nov;10(6):498-506
Authors: Snell HD, Gonzales EB
Guanidine compounds act as ion channel modulators. In the case of Cys-loop receptors, the guanidine compound amiloride antagonized the heteromeric GABA-A, glycine, and nicotinic acetylcholine receptors. However, amiloride exhibits characteristics consistent with a positive allosteric modulator for the human GABA-A (hGABA-A) ρ1 receptor. Site-directed mutagenesis revealed that the positive allosteric modulation was influenced by the GABA-A ρ1 second transmembrane domain 15' position, a site implicated in ligand allosteric modulation of Cys-loop receptors. There are a variety of amiloride derivatives that provide opportunities to assess the significance of amiloride functional groups (e.g., the guanidine group, the pyrazine ring, etc.) in the modulation of the GABA-A ρ1 receptor activity. We utilized 3 amiloride derivatives (benzamil, phenamil, and 5-(N, N-Hexamethylene) amiloride) to assess the contribution of these groups toward the potentiation of the GABA-A ρ1 receptor. Benzamil and phenamil failed to potentiate on the wild type GABA-A ρ1 GABA-mediated current while HMA demonstrated efficacy only at the highest concentration studied. The hGABA-A ρ1 (I15'N) mutant receptor activity was potentiated by lower HMA concentrations compared to the wild type receptor. Our findings suggest that an exposed guanidine group on amiloride and amiloride derivatives is critical for modulating the GABA-A ρ1 receptor. The present study provides a conceptual framework for predicting which amiloride derivatives will demonstrate positive allosteric modulation of the GABA-A ρ1 receptor.
PMID: 27367557 [PubMed - indexed for MEDLINE]
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses.
PLoS One. 2016;11(5):e0155648
Authors: Odeh AN, Simecka JW
Mycoplasmas cause respiratory diseases characterized by persistent infection and chronic airway inflammation. Mycoplasma lung disease is immunopathologic, with CD4+ Th cells determining both disease severity and resistance to infection. Th2 cell responses promote immunopathology, while Th1 cells confer resistance to infection. However, regulatory CD4+ T cells may also have a role in the pathogenesis of mycoplasma respiratory diseases. We hypothesized Treg cells control the severity of the inflammatory lesions and may also promote persistence of infection. To examine this, BALB/c mice were depleted of CD25+ cells, and had increased disease severity due to Mycoplasma pulmonis infection. Increases in mycoplasma antibody responses and lymphocyte infiltration into lungs also occurred after CD25+ cell depletion. CD4+CD25+ regulatory T cells promoted IFN-γ and IL-17 mycoplasma-specific CD4+ T cell responses in vitro and in vivo, while dampening IL-13+ Th responses. Neither IL-10 nor TGF-ß expression was detected in CD4+CD25+ T cells from lymph nodes. Thus, a regulatory T cell population plays an important role in controlling damaging immune responses in mycoplasma respiratory disease but does not contribute to persistence of infection. It appears that a regulatory T cell population preferentially dampens Th2 cell-mediated inflammatory responses to mycoplasma through a mechanism independent of IL-10 or TGF-ß characteristic of "classic" Treg cells.
PMID: 27175511 [PubMed - indexed for MEDLINE]
Effect of adenovirus-mediated RNA interference of IL-1β expression on spinal cord injury in rats.
Effect of adenovirus-mediated RNA interference of IL-1β expression on spinal cord injury in rats.
Spinal Cord. 2016 Oct;54(10):778-784
Authors: Lin WP, Lin JH, Cai B, Shi JX, Li WJ, Choudhury GR, Wu SQ, Wu JZ, Wu HP, Ke QF
STUDY DESIGN: We introduced an adenoviral vector expressing interleukin-1β (IL-1β) small-hairpin RNA (shRNA) into the injured spinal cords to evaluate the therapeutic potential of IL-1β downregulation in a rat model of spinal cord injury (SCI).
OBJECTIVES: The purpose of this study was to investigate the possible protective effects of the IL-1β downregulation on traumatic SCI in rats.
SETTING: Department of Orthopedic Surgery, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, People's Republic of China.
METHODS: An adenoviral shRNA targeting IL-1β was constructed and injected at the T12 section 7 days before SCI. The rats' motor functions were evaluated by the Basso-Beattie-Bresnahan (BBB) rating scale. Immunofluorescence, enzyme-linked immunosorbent assay, flow-cytometric analysis and western blots were also performed.
RESULTS: Animals downregulating IL-1β had significantly better recovery of locomotor function and less neuronal loss after SCI. In addition, IL-1β downregulation significantly decreased tumor necrosis factor-alpha (TNF-α) level and Bax expression, reduced the activity of caspase-3 and increased Bcl-2 expression after SCI.
CONCLUSION: This study demonstrated that the IL-1β downregulation may have potential therapeutic benefits for both reducing secondary damages and improving the outcomes after traumatic SCI.
PMID: 26902461 [PubMed - indexed for MEDLINE]
Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas.
Dopamine agonist resistance-related endocan promotes angiogenesis and cells viability of prolactinomas.
Endocrine. 2016 Jun;52(3):641-51
Authors: Cai L, Leng ZG, Guo YH, Lin SJ, Wu ZR, Su ZP, Lu JL, Wei LF, Zhuge QC, Jin K, Wu ZB
Dopamine agonists (DAs) are the first-line treatment of prolactinomas. They function through the dopamine 2 receptor (D2R) in the tumor cells. Endocan, also called endothelial cell-specific molecule-1 (ESM1), has been described as a marker of neoangiogenesis. However, whether ESM1 promotes the resistance of prolactinomas to DA therapy is largely unknown. In our study, 25 patients with prolactinomas were divided into resistant- and sensitive- groups according to the clinical response to bromocriptine. We found that ESM1-microvessel density of resistant prolactinomas was significantly higher than that of sensitive prolactinomas (47.9 ± 11.6, n = 8, vs 13.1 ± 2.8, n = 17, p = 0.0006), indicating that ESM1 was a DA resistance-related gene. Immunostaining showed that ESM1 was expressed in tumor vessels and sporadic tumor cells, and ESM1 was overlapped with the Smooth Muscle Actin (SMA) and von Willebrand Factor (VWF) in the tumor vessels. Silencing of ESM1 markedly suppressed the viability of GH3 and MMQ cells in vitro, and furthermore, significantly increased the sensitivity of GH3 and MMQ cells to DA treatment. Additionally, silencing of ESM1 down-regulated the angiogenesis-associated genes, such as VEGFR2, FGF2, CD34, CD31, VWF, and EGFR. Knockdown of ESM1 decreased endothelial tube formation of HUVECs, and significantly increased the sensitivity of HUVECs to Avastin treatment. Therefore, we first demonstrate that DA resistance-related ESM1 promotes the angiogenesis and tumor cells growth of prolactinomas, suggesting that ESM1 may be a novel therapeutic target for prolactinomas.
PMID: 26662185 [PubMed - indexed for MEDLINE]
Energetic redistribution in allostery to execute protein function.
Energetic redistribution in allostery to execute protein function.
Proc Natl Acad Sci U S A. 2017 Jul 10;:
Authors: Liu J, Nussinov R
PMID: 28696318 [PubMed - as supplied by publisher]
Potassium as a pluripotency-associated element identified through inorganic element profiling in human pluripotent stem cells.
Potassium as a pluripotency-associated element identified through inorganic element profiling in human pluripotent stem cells.
Sci Rep. 2017 Jul 10;7(1):5005
Authors: Lin VJT, Zolekar A, Shi Y, Koneru B, Dimitrijevich S, Di Pasqua AJ, Wang YC
Despite their well-known function in maintaining normal cell physiology, how inorganic elements are relevant to cellular pluripotency and differentiation in human pluripotent stem cells (hPSCs) has yet to be systematically explored. Using total reflection X-ray fluorescence (TXRF) spectrometry and inductively coupled plasma mass spectrometry (ICP-MS), we analyzed the inorganic components of human cells with isogenic backgrounds in distinct states of cellular pluripotency. The elemental profiles revealed that the potassium content of human cells significantly differs when their cellular pluripotency changes. Pharmacological treatment that alters cell membrane permeability to potassium affected the maintenance and establishment of cellular pluripotency via multiple mechanisms in bona fide hPSCs and reprogrammed cells. Collectively, we report that potassium is a pluripotency-associated inorganic element in human cells and provide novel insights into the manipulation of cellular pluripotency in hPSCs by regulating intracellular potassium.
PMID: 28694442 [PubMed - in process]
Adiponectin: Its role in obesity-associated colon and prostate cancers.
Adiponectin: Its role in obesity-associated colon and prostate cancers.
Crit Rev Oncol Hematol. 2017 Aug;116:125-133
Authors: Muppala S, Konduru SKP, Merchant N, Ramsoondar J, Rampersad CK, Rajitha B, Mukund V, Kancherla J, Hammond A, Barik TK, Mannarapu M, Alam A, Basha R, Bramhachari PV, Verma D, Sushma PS, Pattnaik S, Nagaraju GP
Adipose tissue synthesizes many proteins and hormones collectively called adipokines, which are linked to a number of diseases, including cancer. Low levels of adiponectin are reported to be a risk factor for obesity-related cancers including colorectal and prostate cancers. Accordingly, obesity/lifestyle-related diseases, including certain cancers, may be treated by developing drugs that act specifically on adiponectin levels in circulation. Adiponectin may also serve as a clinical biomarker in obesity-related diseases. Adiponectin-based therapies are known to inhibit cancer advancement and thus may provide a therapeutic approach to delay cancer progression. Better understanding of the function of adiponectin is of great significance in the fight against cancer. This timely review is concentrated on the role of adiponectin and the impact of obesity on the development of cancers, especially colorectal and prostate cancers.
PMID: 28693794 [PubMed - in process]
Optimal Measurement Interval for Emergency Department Crowding Estimation Tools.
Optimal Measurement Interval for Emergency Department Crowding Estimation Tools.
Ann Emerg Med. 2017 Jul 06;:
Authors: Wang H, Ojha RP, Robinson RD, Jackson BE, Shaikh SA, Cowden CD, Shyamanand R, Leuck J, Schrader CD, Zenarosa NR
STUDY OBJECTIVE: Emergency department (ED) crowding is a barrier to timely care. Several crowding estimation tools have been developed to facilitate early identification of and intervention for crowding. Nevertheless, the ideal frequency is unclear for measuring ED crowding by using these tools. Short intervals may be resource intensive, whereas long ones may not be suitable for early identification. Therefore, we aim to assess whether outcomes vary by measurement interval for 4 crowding estimation tools.
METHODS: Our eligible population included all patients between July 1, 2015, and June 30, 2016, who were admitted to the JPS Health Network ED, which serves an urban population. We generated 1-, 2-, 3-, and 4-hour ED crowding scores for each patient, using 4 crowding estimation tools (National Emergency Department Overcrowding Scale [NEDOCS], Severely Overcrowded, Overcrowded, and Not Overcrowded Estimation Tool [SONET], Emergency Department Work Index [EDWIN], and ED Occupancy Rate). Our outcomes of interest included ED length of stay (minutes) and left without being seen or eloped within 4 hours. We used accelerated failure time models to estimate interval-specific time ratios and corresponding 95% confidence limits for length of stay, in which the 1-hour interval was the reference. In addition, we used binomial regression with a log link to estimate risk ratios (RRs) and corresponding confidence limit for left without being seen.
RESULTS: Our study population comprised 117,442 patients. The time ratios for length of stay were similar across intervals for each crowding estimation tool (time ratio=1.37 to 1.30 for NEDOCS, 1.44 to 1.37 for SONET, 1.32 to 1.27 for EDWIN, and 1.28 to 1.23 for ED Occupancy Rate). The RRs of left without being seen differences were also similar across intervals for each tool (RR=2.92 to 2.56 for NEDOCS, 3.61 to 3.36 for SONET, 2.65 to 2.40 for EDWIN, and 2.44 to 2.14 for ED Occupancy Rate).
CONCLUSION: Our findings suggest limited variation in length of stay or left without being seen between intervals (1 to 4 hours) regardless of which of the 4 crowding estimation tools were used. Consequently, 4 hours may be a reasonable interval for assessing crowding with these tools, which could substantially reduce the burden on ED personnel by requiring less frequent assessment of crowding.
PMID: 28688771 [PubMed - as supplied by publisher]
Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.
Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging.
Nat Protoc. 2017 Jul;12(7):1472-1497
Authors: Vinegoni C, Fumene Feruglio P, Brand C, Lee S, Nibbs AE, Stapleton S, Shah S, Gryczynski I, Reiner T, Mazitschek R, Weissleder R
The ability to directly image and quantify drug-target engagement and drug distribution with subcellular resolution in live cells and whole organisms is a prerequisite to establishing accurate models of the kinetics and dynamics of drug action. Such methods would thus have far-reaching applications in drug development and molecular pharmacology. We recently presented one such technique based on fluorescence anisotropy, a spectroscopic method based on polarization light analysis and capable of measuring the binding interaction between molecules. Our technique allows the direct characterization of target engagement of fluorescently labeled drugs, using fluorophores with a fluorescence lifetime larger than the rotational correlation of the bound complex. Here we describe an optimized protocol for simultaneous dual-channel two-photon fluorescence anisotropy microscopy acquisition to perform drug-target measurements. We also provide the necessary software to implement stream processing to visualize images and to calculate quantitative parameters. The assembly and characterization part of the protocol can be implemented in 1 d. Sample preparation, characterization and imaging of drug binding can be completed in 2 d. Although currently adapted to an Olympus FV1000MPE microscope, the protocol can be extended to other commercial or custom-built microscopes.
PMID: 28686582 [PubMed - in process]
Analysis of DNA from post-blast pipe bomb fragments for identification and determination of ancestry.
Analysis of DNA from post-blast pipe bomb fragments for identification and determination of ancestry.
Forensic Sci Int Genet. 2017 May;28:195-202
Authors: Tasker E, LaRue B, Beherec C, Gangitano D, Hughes-Stamm S
Improvised explosive devices (IEDs) such as pipe bombs are weapons used to detrimentally affect people and communities. A readily accessible brand of exploding targets called Tannerite® has been identified as a potential material for abuse as an explosive in pipe bombs. The ability to recover and genotype DNA from such weapons may be vital in the effort to identify suspects associated with these devices. While it is possible to recover DNA from post-blast fragments using short tandem repeat markers (STRs), genotyping success can be negatively affected by low quantities of DNA, degradation, and/or PCR inhibitors. Alternative markers such as insertion/null (INNULs) and single nucleotide polymorphisms (SNPs) are bi-allelic genetic markers that are shorter genomic targets than STRs for amplification, which are more likely to resist degradation. In this study, we constructed pipe bombs that were spiked with known amounts of biological material to: 1) recover "touch" DNA from the surface of the device, and 2) recover traces of blood from the ends of wires (simulated finger prick). The bombs were detonated with the binary explosive Tannerite® using double-base smokeless powder to initiate the reaction. DNA extracted from the post-blast fragments was quantified with the Quantifiler® Trio DNA Quantification Kit. STR analysis was conducted using the GlobalFiler® Amplification Kit, INNULs were amplified using an early-access version of the InnoTyper™ 21 Kit, and SNP analysis via massively parallel sequencing (MPS) was performed using the HID-Ion Ampliseq™ Identity and Ancestry panels using the Ion Chef and Ion PGM sequencing system. The results of this study showed that INNUL markers resulted in the most complete genetic profiles when compared to STR and SNP profiles. The random match probabilities calculated for samples using INNULs were lower than with STRs when less than 14 STR alleles were reported. These results suggest that INNUL analysis may be well suited for low-template and/or degraded DNA samples, and may be used to supplement incomplete or failed STR analysis. Human identification using SNP analysis via MPS showed variable success with low-level post-blast samples in this study (<150pg). While neat DNA samples (6μL input as recommended) resulted in <50% of SNP calls, samples that were concentrated from 15μL to 6μL (15μL was added for STR and INNUL typing) resulted in more complete SNP profiles. Five out of six blood samples recovered from the wires attached to the pipe-bombs resulted in the correct ancestry predictions.
PMID: 28292727 [PubMed - indexed for MEDLINE]
The factor of 10 in forensic DNA match probabilities.
The factor of 10 in forensic DNA match probabilities.
Forensic Sci Int Genet. 2017 May;28:178-187
Authors: Gittelson S, Moretti TR, Onorato AJ, Budowle B, Weir BS, Buckleton J
An update was performed of the classic experiments that led to the view that profile probability assignments are usually within a factor of 10 of each other. The data used in this study consist of 15 Identifiler loci collected from a wide range of forensic populations. Following Budowle et al. [1], the terms cognate and non-cognate are used. The cognate database is the database from which the profiles are simulated. The profile probability assignment was usually larger in the cognate database. In 44%-65% of the cases, the profile probability for 15 loci in the non-cognate database was within a factor of 10 of the profile probability in the cognate database. This proportion was between 60% and 80% when the FBI and NIST data were used as the non-cognate databases. A second experiment compared the match probability assignment using a generalised database and recommendation 4.2 from NRC II (the 4.2 assignment) with a proxy for the matching proportion developed using subpopulation allele frequencies and the product rule. The findings support that the 4.2 assignment has a large conservative bias. These results are in agreement with previous research results.
PMID: 28273509 [PubMed - indexed for MEDLINE]


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Combining pleasant activities with magic landscapes, nice accommodations, traditional meals, specialised guides and friendly people, Lares offers unique experiences, according to the preferences and needs of international travellers. Lares' dedicated team takes every care to work out and offer you a different South American experience which will be memorable and inviting enough for a revisit. Their goal is that international
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Fasano Las Piedras
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Bahia Vik Jose Ignacio
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New Releases from McGraw-Hill SOCIAL PROBLEMS (Second Edition). John J. Macionis. Pearson-Prentice Hall. This highly readable text designed for undergraduate students openly advocates a social-constructionist approach to the study of … Continue reading
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The iStarUSA 24-Bay Storage Server 4U Rackmount Case is a server chassis that offers 24 bays to house your drives and supports motherboards in the size of extended-ATX, ATX, and micro-ATX. These bays are designed to hold 3.5" drives and feature hot-swapping capabilities. With a miniSAS backplane, you may install SAS and SATA hard drives into this chassis. Aside from the 3.5" drive bays, two 2.5" internal bays let you equip this server chassis with SSDs for data caching or other uses. To cool your components, iStarUSA includes three 120mm hot-swap cooling fans that spin at a rate of 3600 rpm. There are also seven expansion slots for your graphics and controller cards. Furthermore, a sliding rail kit is included so you can easily gain access to this 4U rackmount case when installed into your rack.
|Form Factor
|Drive Bays
24 x 3.5" hot-swappable bays
2 x 2.5" internal bays
Drive backplane requires six molex power connectors
Requires a separately sold controller with at least six SFF-8087 or SFF-8643 connectors
|Hot-Swap HDD Type
3.5" SAS I and II
3.5" SATA I, II, and III
|USB Ports
|Indicator LEDs
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|Power and reset
|Expansion Slots
|Material of Construction
|Main Chassis: SGCC cold-rolled steel
|Supported Motherboard
E-ATX, ATX, and micro-ATX
Dimensions of Motherboard Space: 12.0 x 13.0" / 30.5 x 33.0 cm
|Cooling Fans
3 x 120 mm 3600 rpm fans
dBA: 56.5
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|2 x slots support optional 60 mm fans
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|19.0 x 7.0 x 26.7" / 48.3 x 17.8 x 67.9 cm
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|62.0 lb
|Box Dimensions (LxWxH)
|35.2 x 13.3 x 2.1"


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Anthony's Film Review
Biggie and Tupac (2002)
A documentary film that provides an intriguing glimpse into the deaths of two hip-hop superstars...
In the 1990s, the world of hip-hop lost not one but two rap artists to fatal gunfire. In late 1996, Tupac Shakur was gunned down in Las Vegas, and in early 1997, Christopher Wallace, a.k.a. Biggie Smalls, a.k.a. The Notorious B.I.G., was shot to death in Los Angeles. On the surface, particularly to anyone not too interested in rap music, this seems like the case of a rivalry that took a really ugly turn. That may be the official story to some people, but as the 2002 documentary film Biggie and Tupac illustrates, the real story may be far more shocking than it looks.
At first, the film appears to be biographical. Director Nick Broomfield, a British documentary filmmaker, interviews various people who knew Biggie and Tupac, including Tupac's mother, Biggie's mother, Tupac's performing arts teacher, Biggie's co-worker in a grocery store, and even Tupac's biological father. It's rather nice to get a sense of who these two slain rappers were: young creative talented men who were destined for success. These interviews are accompanied by candid footage of Biggie and Tupac that show how innocent they were before they became famous.
This leads into what the film is really about: an investigation into their deaths. To set the scene, Broomfield briefly explains the East Coast-West Coast hip-hop rivalry. Apparently, there are two recording labels that both produce rap music but each want success for themselves. On the East Coast is Bad Boy Records, whose music includes that performed by Sean Combs, a.k.a. Puff Daddy. On the West Coast is Death Row Records, which rapper Snoop Dogg had a contract with. When Biggie signed up with Bad Boy Records and Tupac joined Death Row Records, the rivalry soon became defined by these two performers, not just their record labels.
So if the deaths of Biggie and Tupac did not actually stem from this rivalry, what was behind it? Well, Russell Poole, a former Los Angeles police detective, has a theory: that the killings of Biggie and Tupac were an inside job. Supposedly, Death Row Records producer Marion "Suge" Knight ordered Tupac murdered because the rapper, after achieving phenomenal success, wanted to leave the record label, and the killing of Biggie would be a way to distract attention away from Death Row Records and pin it all on the East-West hip-hop rivalry. It's interesting how, in this film about Biggie and Tupac, the real central character really seems to be Suge Knight.
And that is the direction the rest of this film takes. Broomfield proceeds to interview various former bodyguards and other figures who were close to Biggie and Tupac at the time of their deaths. What's astonishing is how Broomfield explores topics that seem remotely connected but are nevertheless quite relevant, including corruption in the Los Angeles Police Department, as with the Rampart scandal in 1997. With regard to police corruption, this is an important topic for the film, because former LAPD detective Poole believes that there are officers who are in league with Death Row Records, usually as moonlighting security officers, and that the LAPD purposely did not investigate the Biggie-Tupac murders because it would expose these corrupt officers.
I'm not going to say what happens next, but I will say that I thought the last part of the film was worth seeing. It's the kind of ending that brings a sense of closure, even if there really is no true closure. When the film ended, I couldn't help but admire how Broomfield, being a filmmaker from across the Atlantic, got his facts straight when narrating the events leading up to the two rappers' deaths. He is certainly a director who puts emphasis on the content of his film, not so much the look and technical quality of his film, which are relatively low-key and really not important anyway. All in all, Biggie and Tupac is a pretty good documentary, for fans of the two slain rappers and for anyone who enjoys an intriguing mystery with a quest for uncovering the truth.
Anthony's Rating:
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GALVESTON — The island could consider following the example of Houston and other Texas cities in creating new regulations for payday lenders.
The City Council discussed the possibility during a workshop meeting Thursday.
A growing number of Texas cities, including Houston, Austin, Dallas, El Paso and San Antonio, have put limits on payday and auto-title lenders through local ordinance changes.
The short-term, high-interest loans provided by storefront lenders have been criticized for skirting usury laws for years, using loopholes to charge high interest rates. Critics of the industry claim it also preys on low-income and financially uneducated people.
"We have people who are doing business with these institutions that really don't understand what they're getting into when they sign on the dotted line," said District 3 Councilwoman Elizabeth Beeton. "They're being played, and as soon as they sign, they find themselves in a nightmare."
Ann Baddour, a senior policy analyst with Texas Appleseed, a social justice advocacy group, told the council that there were at least eight active payday loan companies in the city. That number does not include lenders who are not registered with the state's Office of Consumer Credit Commissioner or who operate as auto-title lenders.
Baddour presented the council with a sample ordinance that would place a local cap on the interest rates that could be offered by lenders in the city.
"There are no restrictions on what they can do," Baddour said of the current state of payday lenders. "These businesses are actually not lenders, but loan brokers."
Most of the council members, along with City Attorney Dorothy Palumbo, said more research into the topic was needed before a draft ordinance was proposed. They also expressed concern that an ordinance could draw lawsuits from the businesses that would be regulated.
"If you don't want these to come in your community, the best way to do that is to create a community where these aren't needed," said District 4 councilman Norman Pappous.
The council took no action on the issue on Thursday. The topic will likely be left for the next City Council, which will be installed after the May 10 municipal election.
The city does have some rules in place to regulate payday lenders, under its zoning ordinances.
In 2010, the city changed its zoning rules to require that retail lending facilities receive specific use permits before being constructed, and to prevent the businesses from being placed within a half-mile of each other.
Contact reporter John Wayne Ferguson at 409-683-5226 or email@example.com.


text:
Hello, my Fanfic fans. This is a one-shot about two characters who I don't think had any mention on Fanfiction whatsoever, so I figured I'd write a one-shot about them. Here goes.
It was a peaceful day for the first graders of Gallagher Elementary. There were only a few minutes before class started, so the kids were doing whatever until it was time. The First Grade President, known as Sammy, walked into his classroom and sat by his best friend, Jessica. "Jessica!" he greeted.
"Oh. Hi, Sammy."
He then noticed her sad expression. "What's wrong?"
She sighed. "It's about yesterday. I still can't help but feel bad about what I did."
"It's okay, Jessica. You were doing it to save your stuffed bunny. I know it means a lot to you. It was your mom's before she…well, you know."
"I know. But still. I almost got our class bunny killed and ruined the first grade for all of us."
"It doesn't matter now. You saved the bunny and helped get everything back to normal, didn't you?"
"Well, yeah…"
"Then you shouldn't worry about it. Besides, we're still best friends, right?"
"Then that's all that really matters. That wouldn't change whether you fixed everything or not."
She smiled. "Thanks, Sammy!"
Just then, they heard the bell ring.
"Wanna go to the park after school?" he asked.
"Okay!" And with that, the class began and they listened to their teacher's boring lecture.
Well, there's the first ever Sammy/Jessica fic. Apparently, his name really is Sammy. Well…I'll see you later.


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Sep 21, 2010
TORONTO, Sept. 21 /CNW/ - Hydro One is pleased to support this year's International Plowing Match (IPM) and Rural Expo. As part of its support, Hydro One energized Canada's largest rural fair for the eighth consecutive year. The 2010 IPM runs from September 21 to 25 and is expected to draw almost 100,000 visitors from across the province and Canada to St. Thomas, Ontario.
"Every year, Hydro One looks forward to its participation in the International Plowing Match," said Laura Formusa, President and CEO of Hydro One. "Hydro One is proud to be the primary distributor of electricity to Ontario's farmers and rural communities. The agricultural sector makes a vital contribution to our province's economy and culture."
Hydro One's support includes erecting the electricity grid for the Plowing Match, and delivering the electricity that makes the event run. In the six weeks leading up to the fair, apprentice crews receive valuable training as they install 360 poles and 20 kilometres of wire to electrify the fair grounds. Power lines aren't live during the set-up for the match, so it provides a safe and valuable training opportunity for the apprentices. After the fair, the infrastructure will be dismantled and set aside for the next year's Plowing Match.
At the Hydro One tent, the company partners with 4-H Ontario to raise money through offering rides in the high-reach Bronto bucket truck. For a $2 donation to the 4-H, visitors will be lifted 45 metres in the air for a bird's-eye view of the fairgrounds. Year after year, the Bronto continues to be one of the most popular features at the Hydro One tent.
Visitors to the Hydro One tent will have the opportunity to speak with employees and learn more about conservation programs and forestry initiatives. This year, Hydro One is making a special effort to convey important information about changes to electricity bills and the value of electricity in everyday life. Visitors get to spin the 'Wheel of Conservation' to win energy-efficient prizes such as programmable thermostats and compact fluorescent light bulbs.
Hydro One delivers electricity safely, reliably and responsibly to homes and businesses across the province of Ontario and owns and operates Ontario's 29,000 km high-voltage transmission network that delivers electricity to large industrial customers and municipal utilities, and a 122,000 km low-voltage distribution system that serves about 1.3 million end-use customers and smaller municipal utilities in the province. Hydro One is wholly owned by the Province of Ontario.
For further information:
Hydro One Media Relations 24 hours a day at 1-877-506-7584 (toll-free in Ontario only) or 416-345-6868. Our website is www.HydroOne.com


text:
By RANDALL ROTHENBERG
Published: August 8, 1990
In a long-expected move to save his embattled magazine company, Owen J. Lipstein, the publisher of Psychology Today, Mother Earth News and Smart magazines, announced yesterday that he had sold a 50 percent stake in his New American Magazine Company to a Japanese publishing company. The joint venture is one of the few between American and Japanese communications companies.
Mr. Lipstein, who is 39 years old, said that he completed a deal 12 days ago with JICC Inc., the Japanese Independent Communication Company, or JICC Inc., which publishes consumer magazines and books and produces films, video programming, records, compact discs and computer software.
Terms were not disclosed. In late June, when the two companies signed a letter of intent to form their partnership, several communications trade magazines said the Japanese company would pay $7.5 million for its interest in New American. Yesterday, Mr. Lipstein said that figure was low, but refused he declined to comment further on the price.
Mr. Lipstein said an immediate cash infusion would enable New American to restart Psychology Today in the fall, and to mount promotional campaigns for Smart and Mother Earth News.
JICC was founded 20 years ago as a public relations company, eventually diversifying into other communications ventures, said John Suhler, a partner in Veronis Suhler & Associates, the consulting and investment banking firm that brokered the deal. 10 Consumer Magazines The Japanese company's 10 consumer magazines range from Takarajima, which is aimed at teen-agers, to Bessatsu Takarajima, a cultural and political publication. In book publishing, it has acquired the Japanese rights to American titles like ''Summer of '49,'' a baseball history by David Halberstam, and ''Modern Manners,'' a humor book by the essayist P. J. O'Rourke.
Through most of the 1980's, Mr. Lipstein seemed the personification of the modern publishing mogul, building a company whose magazines, which were devoted to health, spiritual well-being and environmentalism, seemed to speak to the concerns of the baby boom generation.
But in making acquisitions, Mr. Lipstein accrued a debt load reportedly as high as $30 million, a figure he disputes.
Strapped for cash, New American suspended publication of Psychology Today, which had a circulation rate base of 875,000, after its December-/ January issue. Smart, with an announced circulation of 250,000, and Mother Earth News, which has a rate base of 700,000, began delivering issues late, causing some advertisers to drop out. flee. Even the sale of American Health to Reader's Digest in February, for $29.1 million, did not alleviate the problems.


text:
why is the foundational criterion for political discussions adversarial? I wonder. And, why is it that the meaning and the connotations of the word politics have been dumbed down to a two party/two ideologies process? In fact, there aren't 2 parties, just different ideological hermeneutics. "It's ideology stupid" says Zizek.
Less Wrong is a community blog devoted to refining the art of human rationality. Please visit our About page for more information.
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'I want to infect you with the tremendous excitement of living,
because I believe that you have the strength to bear it.'
- Tennessee Williams
Life has a way of presenting you millions of beautiful little moments, and I have a sneaking suspicion that the more you acknowledge them, the more they decide to appear. Remember to let yourself see them. Paradise isn't about a certain place that is beautiful. Rather, it's about being part of something beautiful.


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Lower Gill Holidays Ltd
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20% off all short breaks in January in every cottage.
Contact Lesley on 01200 447009 or by email firstname.lastname@example.com to make a booking or for more information.
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For booking enquiries contact:-
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text:
- select colour
it's an internet thing!
it's an internet thing!
"I am at peace with God. My conflict is with Man."
"Sir, my concern is not whether God is on our side my greatest concern is to be on God's side, for God is always right."Charlie Chaplin on Abraham Lincoln
"We need to find God, and he cannot be found in noise and restlessness. God is the friend of silence. See how nature - trees, flowers, grass- grows in silence see the stars, the moon and the sun, how they move in silence... We need silence to be able to touch souls."Charlie Chaplin on Mother Teresa
"When the solution is simple, God is answering."Charlie Chaplin on Albert Einstein
"While I know myself as a creation of God, I am also obligated to realize and remember that everyone else and everything else are also God's creation."Charlie Chaplin on Maya Angelou
"Never trust anyone completely but God. Love people, but put your full trust only in God."Charlie Chaplin on Lawrence Welk
"Life could be wonderful if people would leave you alone."
"I went into the business for the money, and the art grew out of it. If people are disillusioned by that remark, I can't help it. It's the truth."
"I do not have much patience with a thing of beauty that must be explained to be understood. If it does need additional interpretation by someone other than the creator, then I question whether it has fulfilled its purpose."
"I went into the business for the money, and the art grew out of it. If people are disillusioned by that remark, I can't help it. It's the truth."
"Failure is unimportant. It takes courage to make a fool of yourself."


text:
Bike Ride
207 ft
- Begins in:
- Denver, CO, United States
- Created By:
- John Whitbeck
- Description:
- This is a 16.63 mi Bike Ride in Denver, CO, United States. The Bike Ride has a total ascent of 207.03 ft and has a maximum elevation of 5,422.87 ft. This route was created by jwhitbeck on 04/21/2007. View other Bike Rides that jwhitbeck has done or find similar maps in Glendale.
- Type:
- Bike Ride


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Hohenzollernstrasse 1-3
45128 Essen
P.O. Box 7240
Bonn, D-53072
Rheinisch-Westfälisches Institut für Wirtschaftsforschung (RWI Essen)
in Total Papers Downloads
in Total Papers Citations
Immigration, Public Transfers, Attitudes
Attitudes, Minorities, Identification
This is a CEPR Discussion Paper. CEPR charges a fee of $5.00 for this paper.
File name: DP3222.
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Attitudes, minorities, identification
Reading Literacy, School Resources, Quantile Regression
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Reading literacy, school resources, quantile regression
Demographic Structure, Variance Components, GMM
Student Achievement, School Quality, Quantile Regression
schooling, matching, instrumental variables
Peer Group Effects, Learning Environment, School Quality
factor analysis, panel data, sectoral case studies
Labor Mobility, Migration Intention, Intra-EU Migration
program evaluation, identification, active labor market policy, policy reform, evaluation design
Immigration Policy, Evaluation, Identification Assumptions
Labor mobility, migration intention, intra-EU-migration
subjective data, first- and second-generation immigrants, ethnic Germans
Demographic change, cohort size, unemployment
Evaluation, Identification, Spatial Econometrics
PISA 2000, cognitive achievement, identification
Class size, PISA data, bias
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New Delhi, Jan 30: Indian agencies have welcomed the move by the United States of America which has proposed an immigration ban from Pakistan. Among all countries, Pakistan is without a doubt the most dangerous as terrorists have the backing of the ISI, which is one of the most dangerous spy agencies in the world, senior officials with the Research and Analysis Wing tell OneIndia.
Pakistan has produced the likes of Sajid Mir who has been labelled as an international terrorist. Prior to plotting the Mumbai 26/11 attack, he was in France setting up an international cell for the Lashkar-e-Taiba. The investigation that was conducted clearly indicated that he was roping in several persons from Pakistan to carry out attacks across the globe.
Indian officials say that the ISI has been picking several youth to immigrate into other countries to carry out terror strikes. Groups such as the al-Qaeda and the Lashkar-e-Taiba have always made it clear that the US and Israel are on top of their hit list.
As per the executive order visitors from countries like Pakistan and Afghanistan are subject to extreme vetting. White House Chief of Staff Reince Priebus says, "We're not going to advertise to the world that we're going to put a stop or at least a further vetting on travel in and out of our country from these seven places.
Some people have suggested, that, well, maybe we should have given everyone a three-day warning. But that would just mean that a terrorist would just move up their travel plans by three days. Identifying too many people in these countries and giving them a heads-up in these countries would only potentially flag the executive order for bad order," Priebus said.
The White House on Sunday said there is a possibility in the future of including Pakistan in the list of countries from where immigration has been banned. This is for the first time that the Trump administration has publicly acknowledged about considering putting Pakistan into that list. Currently as per the executive order, visitors from countries like Pakistan and Afghanistan are subject to extreme vetting.
(With agency inputs)
OneIndia News


text:
Young Scooter is currently gearing up to release a new project before the year is through and today he surfaces with the first official sounds from the mixtape. With production from Chophouze, Scooter calls on the one and only Young Thug to collaborate on a defiant, unrelenting single titled "We Ready." Young Scooter's highly-anticipated mixtape Married To The Streets 2 is coming soon.
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With a stay at Lotus Lodges in Sassafras, you'll be close to Dandenong Ranges National Park and Puffing Billy Steam Train. This cabin is within close proximity of National Rhododendron Gardens and Alfred Nicolas Gardens.
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Take in the views from a garden.
Business, Other Amenities
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text:
Wednesday, June 22, 2011
49일 / 49 days
# Title: 49일 / 49 Il
# Genre: Fantasy, romance
# Episodes: 20
# Broadcast network: SBS
# Broadcast period: 2011-Mar-16 to 2011-May-19
* Lee Yo Won as Song Yi Kyung
* Nam Gyu Ri as Shin Ji Hyun
* Jo Hyun Jae as Han Kang
* Bae Soo Bin as Kang Min Ho
* Jung Il Woo as Scheduler / Song Yi Soo
* Seo Ji Hye as Shin In Jung
49 DAYS is the story of a young woman (Shin Ji Hyun) who gets into a car accident a week before her wedding. The accident led to her being in a coma. To revive she has to gather the genuine/sincere tears of 3 people who are not members of her family within 49 Days. To fullfill her mission she will be guided by the Scheduler into possessing the body of another woman, Song Yi Kyung. She will be aided further by her friend from high school Han Gang, who will then get into an entangled relationship with Song Yi Kyung and Shin Ji Hyun.
49 Days OST (released on April 20)
01 49 Days
02 Forgettable (Seo Young Eun)
03Tears Necklace (INST)
04 Nothing Wrong (Jung Yup)
05 Can't Happen? (Tim)
06 Soul Change (INST)
07 Feeling's There (Navi)
08 Silent Regrets (INST)
09 Scarecrow (Jung Il Woo)
10 Until When (Park Boram (Superstar K2)
11 Devil's Tears (INST)
12 Because There's One Heart (J-Symphony)
13 The Circle of Life (INST)
Posted by litalita at 8:08 AM
Labels: drama korea
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text:
What would your thoughts be if : RICHIE JUST SHOWED UP AND WALKED ON STAGE
Posted in the Bon Jovi Forum
#1 Jun 20, 2013
I was thinking about all the discussions that Jon may be seen by Richie as making it hard for him to come back. It reminded me about the dispute between Steven Tyler and Joe Perry. What would your reaction be if Richie was to do what Steven did when he just showed up at Joe's " Joe Perry Project ", after hearing that Joe had replaced him as lead vocals. Do you think Richie would be welcomed or kept off ? I understand that it's not the same venue as the current World Tour w/ Bonjovi, but I thought it would make for some real good discussions ! The Youtube video of Steven's "play" is : youtube.com/watch...
I hope that is correct, if not The title was Steven Tyler NOT QUITTING sings walk this way with Joe Perry Project
#2 Jun 20, 2013
well I guess it's obvious I need computer lessons ! Most of that video link didn't show up ! I'm going to put the rest of the link here and hope it shows up, if not try the title name if you want to. So after the you tube... it was
Since: Jan 09
New Jersey
#3 Jun 20, 2013
If he just shows up without his "personal issue" resolved, he will not be welcome and kept off stage.
"Pet me. Now!"
Since: Aug 08
in the Delta land
#4 Jun 20, 2013
Personally I would think Jon's backbone had turned to mush if, at this point, he lets Richie pick and choose where he plays and who he plays for. No, I'm not anti-Richie I'm pro fan. Play for everyone or no one.
#5 Jun 20, 2013
This would make for great discussion. Steven and Joe's relationship has always been stormy and complicated. Aerosmith is truly a band they split all monies 5 equal ways. It has been like this from day one. When Steven showed up at Joe's solo gig, he mainly did it to piss Joe off and he did. Steven had his GF Erin with him that night and that was more fuel for the fire.
I cannot see any situation where Richie will just walk on stage. In spite of what the Brothers Grimm have been preaching since day one, Jon is not letting Richie come back. Richie even said so. He also said the fans are not getting their monies worth. BJ is not a band it is a cooperation and the CEO is Jon. It would be hard to compare the BJ situation to a normal band. It is my belief that BJ only claims to be a brotherhood. Steven and Joe truly are brother's. I would say Richie would be kept off.
#6 Jun 20, 2013
pebeamann thanks for the thread.
#7 Jun 20, 2013
You're welcome. I find it really really funny that I tried to start a little thread different from all the rest and get judged as spam, nuts, clueless even off topic ! LOL
Not too many on here can even just go with something and talkabout it . I thought that scenario would have been a blast to speculate about ! Thanks for your perspective ! I would love to see him try it though, it would be priceless ! I wish I did know how to put the Tyler/Perry video up here, I am clueless on that one LOL !
"Pet me. Now!"
Since: Aug 08
in the Delta land
#8 Jun 20, 2013
Speaking of videos and Aerosmith, could you see Richie doing this to Jon? LOL
Sudbury, Canada
#9 Jun 20, 2013
No I really can't see that. I believe that they will sort through their issues but if they can't I don't think they would get on stage together with that much animosity.
#10 Jun 20, 2013
No, I can't see Richie doing that one ! hahaha, maybe you could help me put up the other video that I was trying to post ! Thanks for the post !
Winnipeg, Canada
#11 Jun 20, 2013
Your link works.:)
While the circumstances are obviously different, I think it would be f'n awesome if Richie did that and I believe he will be back!
#12 Jun 20, 2013
No I cannot see that happening. This is one of the times they were fighting. What I like about it, notice Joe watching Steven after he did it. Then he goes back and helps him up. I laugh every time I see this one.
Winnipeg, Canada
#13 Jun 20, 2013
No but maybe the thought has crossed his mind. ;)
Just kidding! lol
Love Aerosmith though...those two need to get their $hit together.
#14 Jun 20, 2013
Don't worry about the icons there just decorations to make your post look more colorful. ; )
#15 Jun 20, 2013
My Lord I can make a horses a## out of myself ! I just saw that my link does work ! I have not been able to do any kind of Judging now, page just jumps up to the top. of course it could be me ! I would really like to see Richie walk out on stage, not as an insult to the one's he has missed, just to say, "hey, I'm back " I'm not talking about any specific venue either. Just back on the tour anywhere. I wonder what Phil X would do too ! It would be an epic moment IMO
Since: Jul 11
Location hidden
#16 Jun 20, 2013
LMAO Thanks for posting it Spiders Mom. Love it!
Weeks ago I asked why couldn't Richie just show up at a concert considering he's saying Jon's making it hard for him to come back. People answered that he'd never make it to the stage. My reply then and now is if that did in fact happen it would be evidence for Richie that he wasn't allowed back.
However, since he hasn't shown up willing to play I'm left with only one thought. I'm wondering if he isn't doing it because if he showed his fans that Jon is in fact not allowing him to play that Jon may, in turn, reveal why he wasn't allowed on stage and what he needs to do in order to rejoin the tour.
Can anyone think of any other reason he wouldn't just go to a venue and get up on stage? Even if he's in some kind of tiff with Jon or any other reason for him being away. Why couldn't he put whatever it is aside for the night and show up for his fans or at least try to?
Since: Jun 13
Location hidden
#18 Jun 20, 2013
I've wondered this myself, along with: How can Richie let Phil X stand up there night after night and play the solos that Richie wrote? If Richie is "an artist first" as he said in that Tweet, and if the fashion line isn't keeping him from touring, then what is?
I still think this is some sort of power play between Jon and Richie, whatever the origins of the issue. They are circling each other, so-to-speak. When Jon says Richie is welcome back whenever he is ready, he's making it sound like Richie /could/ just walk up on that stage. But I really think Jon might mean, "Richie is welcome back whenever he is ready (to agree to my terms)".
But if Richie is "taking a stand", he won't return on Jon's terms. Instead, Richie says, "Jon wants to see if he can fill stadiums by himself." Richie seems to hope Jon will "fall on his face", come back and say, "Yes, Richie, it turns out I do need you, so I'll agree to your terms as long as you come back."
That's just my take on this. That said, I would love if Richie were to just show up and walk on stage. I can't even watch the vids with Phil X this time around (I did a bit in 2011, because I knew the circumstances of Richie's absence then and knew he would be back). I have nothing against Phil X or his playing, but he's not Richie. To me, Richie completes the "magic" that is Bon Jovi.
Since: Feb 07
Guelph, Canada
#19 Jun 21, 2013
IMO...at this point in time...Richie's just showing up could very well end up alienating a large number Richie's diehard supporters because there are many who decided to secure refunds and not go to Bon Jovi concerts when Richie would not be part of the show even though it was at a financial cost to those who had to change flights or lose deposits.
The announcementment was made that Richie would not be part of the SA/EU tour leg and I feel it should stay that way. When the day comes that Richie decides he wants to return to Bon Jovi, I would hope it's at the beginning of a tour leg and not the end.
Since: Jul 11
Location hidden
#20 Jun 21, 2013
That's a good point. One I hadn't considered, probably because I'm still going to go to concerts whether he's there or not. Thanks Mgemay.
Since: Feb 07
Cobourg, Canada
#21 Jun 21, 2013
Welcome...I am too. I've also bought tickets for more shows that have gone on sale after April 2 when Richie decided not to show up for work.
I know some fans who had tickets to several shows on this current leg and decided they would go to one or two before making any decisions. Some found they were happy enough to continue without Richie on stage. Others just didn't like it and then went about getting refunds and cancelling plans for the rest of their shows. Those are the fans who I think would be the most affected by Richie just showing up at one of the shows and jumping back on the tour.
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text:
Choose Between Two Options
- $16 for a tasting flight for two ($24 value)
- $30 for a tasting flight for four ($48 value)
North Center Brewing Company
Just about everything at North Center Brewing Company is Michigan-made, from the furniture to the guys who founded the place. Owner Kevin DeGrood and his longtime friend, brew master Drew, opened the brewery's doors in April 2015, around five years after the pair began experimenting with home brewing.
From the outset, Kevin and Drew made sure their facility was Michigan to its core: it was designed by a firm in Northville, a company in Lake Orion milled the equipment, and even some of the wood inside came from a 130-year-old barn in Owosso. Visitors can sip whatever beer's on tap inside the brewery's bright, open space, where there's plenty of seating and a shuffleboard table.