text:
Change parameter and run cases parallel
I am running 2 way FSI on blood vessel using ANSYS workbench and CFX. It's a cylinder, 20mm diameter, 200mm length, 3mm thickness.
I have a lot of issues even start to run the simulations, and always get this error: "Fatal error occurred when requesting Total Mesh Displacement for Interface"
Only one case that works so far, I impose a pressure pulse of 0.01s (peak 1600 Pa) and 0.01-0.02s 0 Pa, I used both Hex meshes for solid and fluid.
Time step = 0.001s, Step end time = 0.02s. And this is the only case that works (Young's modulus = 1.33e7). Outlet boundary is opening type, pressure =0.
Since I m trying to make it more physiologic, I need to lower down Young's modulus to 1.33e5 - 1.33e6. But once I change that the error that I mentioned show up.
Also, I am trying to impose velocity/flow boundary conditions because that's something I need to do eventually. However, I tried different times and same error stopped my simulations again at the first time step. I read some forum threads but I didnt get the exact solution of my problem. So I have a couple of questions hope anyone can help me with:
1) Since I want to play with different parameters: e.g. mesh type, mesh size, time step, inlet outlet profiles on the same ansys workbench file to fine tune to the condition I need, I don't want to setup cases for each of them. Instead, I want to run them all at the same time as I can run on different nodes on my server. I wonder is there anyway to do that, instead of creating many different workbench file to do that?
2) How can I determine the best time step of my problem? (I guess if I can figure out the 1st problem then I can try running with different timesteps here)
3) I wonder do I need to add some sort of stability/source term at my FSI boundary? I am a newbie to FSI simulations so if anyone can offer me some guidance it would be greatly appreciated.
Thanks a tonne in advance! :)
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Psychological Stress and Cancer
The complex relationship between physical and psychological health is not well
understood. Scientists know that many types of stress activate the body's endocrine system, which in turn can cause changes in the immune system, the body's
defense against infection and disease. However, the immune
system is a highly specialized network whose activity is affected not only by stress
but by a number of other factors. It has not been shown that stress-induced changes
in the immune system directly cause cancer.
Some studies have indicated an increased incidence of early death, including
cancer death, among people who have experienced the recent loss of a spouse or
other loved one. However, most cancers have been developing for many years and
are diagnosed only after they have been growing in the body for a long time (from
2 to 30 years). This fact argues against an association between the death of a
loved one and the triggering of cancer.
The relationship between breast cancer and stress has received particular
attention. Some studies of women with breast cancer have shown significantly
higher rates of this disease among those women who experienced traumatic life
events and losses within several years before their diagnosis. Although studies
have shown that stress factors (such as death of a spouse, social isolation, and
medical school examinations) alter the way the immune system functions, they have
not provided scientific evidence of a direct cause-and-effect relationship between
these immune system changes and the development of cancer. One NCI-sponsored
study suggests that there is no important association between stressful life events,
such as the death of a loved one or divorce, and breast cancer risk.* However, more
research to find if there is a relationship between psychological stress and the
transformation of normal cells into cancerous cells is needed.
One area that is currently being studied is the effect of stress on women
already diagnosed with breast cancer. These studies are looking at whether stress
reduction can improve the immune response and possibly slow cancer progression.
Researchers are doing this by determining whether women with breast cancer who are
in support groups have better survival rates than those not in support groups.
Many factors come into play when determining the relationship between stress
and cancer. At present, the relationship between psychological stress and cancer
occurrence or progression has not been scientifically proven. However, stress
reduction is of benefit for many other health reasons.
*"Self-Reported Stress and Risk of Breast Cancer," Felicia D. Roberts, Polly A. Newcomb, Amy Trentham-Dietz, and Barry E. Storer. Cancer, March 15, 1996.
"Stress and Immune Responses After Surgical Treatment for Regional Breast Cancer," Barbara L. Andersen, William B. Farrar, Deanna Golden-Kreutz, et al. Journal of the National Cancer Institute, January 7, 1998.

subset: commoncrawl


text:
Religion Briefs, Jan. 3, 2014
January 2, 2014
EarthSpirit Center for the Transformational Arts
Rev. Dr. Nanci Shanderá Women's Mystery School, Wednesdays at 6 p.m.; classes in Transformational Healing of Spirit, Mind, and Body; Dreams; Elderhood Wisdom Training; Alchemy; Shamanism; Ritual in our Stone Circle; ongoing Healing group for those dealing with cancer (at SNMH hospital); monthly Sierra Center for Spiritual Living Women's Circle. Spiritual counseling for women; check website and EarthSpirit Center on Facebook for event schedule, online classes, and Dr. Nanci's books.
For more information, visit http://www.EarthSpiritCenter.com or email
Holy Wisdom, Nevada City
This Sunday we will celebrate the feast of Theophany-celebrating the baptism of Christ. The Holy Trinity appeared clearly to mankind for the first time—the Father's voice is heard from Heaven, the Son of God is incarnate and standing physically in the Jordan, and the Holy Spirit descends on Him in the form of a dove.
Recommended Stories For You
Wednesday Vespers at 5:30 p.m. and Sunday Divine Liturgy at 9:30 a.m.
For more information, call 530-265-4714 or visit http://www.holywisdomnevadacity.org.
Christian Science Church
Tuesdays: Come on by to visit our weekly live audio chats, including Q&A. On Tuesday, January 7, the topic is, "United against divisiveness." Whether there's division in your household, at church, at work, or in government, there is a healing answer. If you're looking for solutions to divisiveness in any part of your life — join this chat with a Christian Science practitioner and teacher and with a Christian Scientist who has founded an organization that is working for world peace. We meet every Tuesday from 11:00 a.m. to noon at 147 Mill St. (our bookstore for spiritual resources). Visit
http://christiansciencegrassvalley.org for the most recent topic and further information.
Wednesdays: Join our open Wednesday Meetings for sharing about healing
from 7:30 to 8:30 p.m. After hearing verses from the Bible and Science and Health with Key to the Scriptures by Mary Baker Eddy on a theme, participants are invited to share personal examples of Christian healing and gratitude for God's care. The meeting is followed by greeting and fellowship.
Stop by any Sunday at 10 a.m. to visit our weekly worship service centered on a sermon directly from the Bible and Science and Health. A Sunday School is held at the same time where students up to the age of 20 learn all about the Bible and how to apply its timeless spiritual lessons in their lives (childcare is provided).
First Baptist Church, Grass Valley
This New Year let us "Honor the Past and Embrace the Future!" Pastor Mark Rindels is beginning the new year with a challenge to honor the past, but move forward in the future God has for us. Traditional service at 9 a.m. features a mix of praise songs and hymns. Sunday School for adults, youth, children and preschoolers is provided. Contemporary service 11 a.m. features upbeat praise music. Join us Wednesdays for dinner at 4:45 to 6 p.m. in the Upper Fellowship Hall. Prayer, Bible Studies, Children's activities and youth group follow. Celebrate Recovery, a Christ based 12-Step program meets in the Lower Fellowship Hall at 6:30 p.m.
Call 530-273-7301, or visit http://www.firstbaptistgv.com for details.
Sierra Center for Spiritual Living
Come celebrate with us and Rev. Lani Howard Sunday morning. Her Inspirational talk is titled "The Nature of Being." Enjoy the live, uplifting music of Jeff Wright and Friends at both the 9:30 and 11 a.m. services. Families with Children are welcome to join us. Child care is available at the 11 a.m. service. A Family Room with audio is available if needed at the early service.
We are an interfaith community committed to awakening humanity to its spiritual magnificence. Our vision is "Celebrating Our Oneness In Spirit." We are at 119 Florence Avenue in Grass Valley.
For more information or a parking map, visit http://www.sierracenter.org or call 530-274-1018.
Mountain Stream Meditation Center
Our Buddhist Insight Meditation group meets every Monday from 7 to 8:30 p.m. at Mountain Stream Meditation Center, 710 Zion St., Nevada City. Please carpool.
On January 6, guiding teacher John Travis will lead a period of silent meditation followed by a dharma talk. January 6 is also "Beginner's Mind Monday," with a special welcome and introductory instructions for new friends at 6:30 p.m.
Our group also meets at the Center for meditation and discussion on the second and fourth Wednesdays of the month from 7:30 to 9 p.m.
Information: http://www.mtstream.org or 530-265-6111. Follow Mountain Stream on Facebook.
Grass Valley United Methodist Church
Our Contemplative Service begins at 8:45 a.m. Our Traditional Service begins at 10:30 a.m. Coffee fellowship follows each service. You are invited to join us for either service. Sunday School is held during the 8:45 service for ages 3 to 12 with chimes and drama 9:45 to 10:30. Child care for all ages 8:30 until noon.
Worship for Young Families (WOW), will meet on Wednesday, January 8, at 5 p.m. with a chili potluck at 5 followed by a Worship Service at 5:30 p.m. with Rev. Tana speaking on "Judas: The Value of a Dollar."
Please feel free to call the church office at 530-272-1946 for further information.
Twin Cities Church
Join us as we begin our new series "RE:NEW." The message this week is "RE:FRESH." We meet Sundays at 8:00, 9:35, and 11:15. Our Children's Ministry (birth through 5th grade) has fantastic children's programming at each of our services. High School Students meet Sundays at our 9:35 service, and Junior High School Students meet at our 11:15 service.
You can listen to past messages on KNCO 830AM on Sunday mornings at 7:00 a.m., or you can check out videos of our messages and services at our website – http://www.twincitieschurch.com. Find more information visit our website or our Facebook page – http://www.facebook.com/twincitieschurch, or call us at 530 273 6425.
Grass Valley Seventh-day Adventist Church.
Worship Schedule:
January 4: Pastor Tim McMillen
January 11: Pastor Jeff Richards, "My Pastoral Prayer: Give Glory to God"
January 18: Pastor Jeff Richards, "My Pastoral Prayer: The Riches of His Glory
January 25: Pastor Jeff Richards, "My Pastoral Prayer: Christ Dwells in Our Hearts"
Saturday worship times: Adult/youth/children Bible classes from 9:30 to 10:30 a.m., morning worship service: 10:40 a.m. to noon. Services are also held in Spanish in the fellowship hall. Everyone is invited to join our weekly fellowship meals following the Saturday service. Pathfinder & Adventure Children's Clubs meet each Tuesday at 5:30 p.m. at Echo Ridge Christian School.
We are located at 12889 Osborne Hill Road in Grass Valley (Just past Union Hill School on Hwy. 174). Visit our website at http://www.gvadventist.com, or call 530-477-5017 or email firstname.lastname@example.com.
St. Canice Roman Catholic Church
Pope Francis on Wednesday called for greater solidarity in the world in his first New Year blessing as pontiff in front of crowds of pilgrims on St. Peter's Square.
"We all have a responsibility to act so that the world may be a community of brothers who respect each other, who accept their diversity and who take care of one another," the pope said on Catholic World Peace Day.
The first pope from Latin America said violence and injustice "cannot leave us indifferent or immobile" and said 2014 should bring "a real commitment to build a society with more justice and more solidarity.
"We have to stop on this road of violence! What is happening in the heart of man? In the heart of humanity? We have to stop!" the pope said.
Francis said he hoped that greater "fraternity" and a "cry for peace" from war-torn parts of the world would encourage more dialogue and "tear down walls that prevent enemies from seeing each other as brothers."
At a New Year mass in St. Peter's Basilica earlier on Wednesday, Francis prayed in his homily for people "who hunger and thirst for justice and peace" in the world.
Francis was elected in March 2013 following his predecessor Benedict XVI's momentous resignation — a first for the Catholic Church since the Middle Ages. His down-to-earth style and commitment to reforming the Vatican have raised hopes in the Roman Catholic Church.
Come celebrate with us
Daily Mass at 7:30 a.m. Mon. through Friday; Saturdays at 5:30 p.m.; Sundays at 8, 9:30 and 11 a.m.
We are located on Washington St. in Nevada City.
The Unitarian Universalist Community of the Mountains (UUCM) in Grass Valley
We are sad to announce the departure of the Rev. Meghan Cefalu, our first "settled" minister, after 7 and a half years of service. She has been called to the First Unitarian Society in Newtown, Mass. and began the first of this year.
A large potluck gathering on December 15 marked the Community's official farewell to their beloved minister.
The Rev. Cefalu received her Masters Degree in Divinity from Starr King School of Ministry in Berkeley CA in 2005 and began her employment as UUCM's first "settled" minister in 2006. Under her leadership UUCM has experienced a significant increase in membership, along with expansion of Religious Education and other church programs, and major improvements to the church facility.
Janet Dunstan, President of the UUCM Board of Trustees said, "Rev. Meghan taught us about the power of interpersonal relationships and how it transforms our lives. Because of her, we are a community of loving, caring people who welcome diversity and live by our Covenant of Right Relations. We have all become more fully human…an amazing experience. She will be sorely missed."
UUCM will be served for the next six months by contract minister, the Rev. Denis Paul of Modesto, Calif. The Rev. Paul is warm, dynamic, and rich in experience.
The Unitarian Universalist Community of the Mountains is a welcoming congregation open to all. UUCM is located at 246 Church Street in Grass Valley (the one with the rainbow flag). Contact 530-274-1675, or visit the website at http://www.uugrassvalley.org.
Unity in the Gold Country
We are located at 180 Cambridge Ct., Grass Valley, off Whispering Pines Lane, across from Peaceful Valley Farm Supply. The Way of Mastery is held each Monday at 7 p.m. The Men's and Women's Groups meet each Tuesday at 10 a.m. A Course in Miracles every Thursday at 7 p.m. Our Children's Ministry program is held each Sunday at 10:30 a.m. The Brazilian Healers return Wednesday, January 8. The Keys to the Kingdom, Prosperity Class begins Tuesday, January 14.
Sierra Pines United Methodist Church
9 a.m.: Contemporary Service and 10:30 a.m. Traditional Service.
Junior High and High School Ages: Youth Group on Sundays from 4 to 6 p.m. Hilltop Kids" Sunday School at 9 a.m.
Sierra Pines United Methodist Church is located at 22559 Hacienda Drive, in Grass Valley (near Lake of the Pines) " For more information telephone the Church Office at 530-268-6907 and visit our website at http://www.sierrapinesumc.org.
Word-A-Live Church
Pastors Mike and Sandra Chipchase invite you to Word-A-Live! Church at 10 a.m. Sundays at 10528 Spenceville Road in Penn Valley. Word-A-Live! Is worth the drive! Word-A-Live offers a variety of programs, including:
Monday from 7 to 9 p.m.: "A-Live! Recovery," learning to be free from life-controlling behaviors.
Thursdays at 9: 45 a.m.: Women's Bible Study: Series, "How to hear from God."
Fridays, 6 to 9 p.m.: Culture Revive Youth ages 12 to 18.
Saturdays, 5 p.m.: Corporate Prayer.
Wednesdays: 7 to 9 p.m.: Equippers Classes. "Night is Time for Change" (The need for a new Wine-Skin in the church today).
For more information, visit http://www.word-a-live.org or call 530-432-9155.
Sierra Presbyterian Church
Our services are 9 a.m. Traditional and 10:30 a.m. Contemporary. Children's programs, healing prayer and adult Sunday school are also at 9 and 10:30 a.m. Visit our website at http://www.sierrapres.com, to read our newsletter online and like us on our Facebook page. We are located at 175 Ridge Road, Nevada City. For more information, call 530-265-3291.
The Palestine-Israel Working Group of Nevada County (PIWG)
PIWG advocates for human rights, equality and justice for all in Palestine and Israel. We meet on the third Tuesday of each month at 7 p.m. a private home.
Please call 530-713-1131 for location and directions. We also maintain a weekly vigil of Women and Men in Black Thursdays, 5:15 to 6 p.m. on the Broad Street bridge in Nevada City.
Anchored Encouragement
Presenting the teachings of Jesus. We meet at 10 a.m. at Valentina's Bistro & Bakery the first, second and third Sundays of each month.
The bistro is located at 1041 Sutton Way in Grass Valley. For more information, call Carl Jones at 530-263-8050 or visit anchoredencouragement.com.
Metaphysical discussion group
Come share your thoughts, bring your joy and meet like-minded new friends. For information, call Lee Ann at 530-272-2945.
Grass Valley AM AGLOW
We are a local chapter of Aglow International, meets the second Tuesday of every month from 9:45 a.m. to noon at 336 Crown Point Circle, Grass Valley. Take Brunswick Road to Whispering Pines Lane, left on Crown Point Circle and then right at Nevada County Board of Realtors. Baby-sitting off site is available by making reservations in advance with Jamie Bartsch at 530-272-6056.
Brother, can you spare an — hour?
A group of local men meets from 6 to 7 a.m. Thursdays at Penny's Diner for breakfast. Under the banner of "Christian Business Men's Committee," we have breakfast, read a portion of scripture, share what God has done in our life and pray. Penny's Diner is located at 2072 Nevada City Highway in the B&C Fowler Center in Grass Valley.
Hope Bearers
We are a Christian cancer support group that meets at Foothill Church.
Those with serious chronic illnesses, including cancer, and their care givers are encouraged to come and share in a safe environment concerning this difficult time. Family, friends and caregivers are all welcome. Meetings are 6 p.m. the first and third Saturdays of every month. Located at 14600 State Highway 49, Grass Valley.
For information, call Edda at 530-432-2862 or visit http://www.FoothillChurch.org/hope_bearers.
The Healing Rooms of Nevada County
Need healing? Physical or emotional? The Healing Rooms of Nevada County pray for healing of body and spirit. Everyone is welcome whether they attend church or not. Come to the Main Lobby of the Sierra Nevada Memorial Hospital, 155 Glasson Way, Grass Valley on the first and third Thursdays of each month, 7 to 8:30 p.m. There is no fee and no appointment is necessary. Also, Tuesday mornings from 9 to 11:30 a.m. healing ministry is available by appointment only. For more information, call Sierra Ministries International at 530-478-1478 or visit http://www.healingroomsnc.com.
Pray Nevada County
We are seeking God on behalf of our communities. Open to all for Christian prayer, Pray Nevada County meets each Tuesday from noon to 1 p.m. to pray for our county governments and services, schools and families, businesses and media, and churches and parachurch ministries. Since August 1997, 15 to 25 people from eight to 12 congregations have met each week to pray for our communities.
For more information or directions, call the scheduling secretary at 530-432-0458 or Sierra Ministries International at 530-478-1478.
Emmanuel Episcopal Church
Grass Valley's Emmanuel Episcopal Church has added an additional Sunday morning service:
7:30 a.m. – Rite I Holy Communion with no music.
9 a.m. – Rite II Holy Communion with music and Nursery
10:30 a.m. – Rite II Holy Communion with organ/choir, Nursery, and Sunday school.
Coffee and fellowship in Buck Hall follow each service.
Emmanuel Episcopal Church, 235 S. Church St., Grass Valley.
For more information, call 530-273-7876, email firstname.lastname@example.com or visit http://www.emmanuelgv.org.
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Cutbacks in retail and the auto industry sent job reductions soaring to over 50,000 in May, outplacement consultancy Challenger, Gray & Christmas reported Thursday.
The total of 51,692 in May was 41 percent higher than the 36,602 job cuts announced in April and 71 percent higher than in May 2016, when U.S.-based employers said they would lay off 30,157 workers.
Nearly 40 percent of the May cuts were announced by Ford Motor, Challenger said.
"Ford's announcement of 20,000 global layoffs to streamline and cut costs is a typical strategy of large corporations who need to pivot to stay competitive," John A. Challenger, CEO of Challenger, said Thursday morning. "
Read the Full Article at www.cnbc.com >>>>
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Source: EW Magazine Archive
Can you believe that 20 years ago, it was 1995? I don't know about you, but in my opinion, 1995 was both a good year & bad year, but the good outweighed the bad overall. For reasons of which I will outline below.
1995 will go down for me as my favourite year: I turned 14 in February, I had a rough time in high school fitting in, and with that, I was mercilessly bullied by some of my classmates and other pupils. I enjoyed my studies and the subjects I was taking, but other than that, I loathed being in high school and wanted to get out of there. So from a personal point of view, it was a dreadful time and thus, I had to move past this and focus on being positive.
In spite of all this, when I got home, turned on the radio or TV and switched on Cartoon Network, Trouble or Paramount Comedy channel to watch American sitcoms and cartoons, it made me forget about all those internal problems at school. It was the movies, the songs, the shows that made me smile, laugh, have fun.
1995 will be best remembered by me for the following: (facts from Wikipedia and History Orb)
Gangsta's Paradise - Coolio; taken from the motion picture soundtrack of Dangerous Minds starring Michelle Pheiffer
Waterfalls - TLC
Kiss From A Rose - Seal
Shy Guy - Diana King, from Bad Boys movie
Britpop - I was a bit of an emo indie kid back in the days with the whole Britpop thing involving bands Blur, Oasis and Pulp. It was interesting when it happened, but since then, I have grown out of that alternative pop faze and embraced pop altogether. I don't listen to those records these days, more-so it's pop and R&B.
OJ Simpson is found not guilty of killing his ex - wife and her partner
the WTO (World Trade Organisation) is formed
Richie Edwards of Welsh indie rock band, Manic Street Preachers goes missing. He was later declared 'presumed deceased' in 2008.
The UN charges Bosnia for acts of genocide and crimes against humanity
Yahoo! the first internet search engine is founded
On an episode of chat show The Jenny Jones Show, a guy named Scott Amedure reveals he has a crush on his heterosexual friend, Jonathan Schmitz - who subsequently kills Scott several days after the show's taping. The episode never aired on US TV and the show was made to pay $25 million in compensation to Amedure's family.
Jacques Cirac is elected as president of France
The DVD is announced as the successor to the VHS, videotape
eBay is founded in the U.S, was then known as 'Auction Web '
The Queen (Elizabeth) advises an early divorce to Lady (Princess) Diana and Prince Charles, which is later finalized in 1996
U.S gymnast Gabby Douglas was born on December 31 in Virginia Beach, Virginia
Source: People.com
U.S Swimmer Missy Franklin was born on May 10 in Pasadena, California
Bad Boys - movie starring Will Smith and Martin Lawrence
While You Were Sleeping - romantic comedy movie starring Sandra Bullock and Bill Pullman
Batman Forever
Clueless - movie starring Alicia Silverstone, which later inspired Iggy Azalea's music video for the 2014 hit single, 'Fancy'.
Babe - movie about a talking pig and other talking animals
Jumanji, Friday, Se7en, Toy Story, Ghost in The Shell, While You Were Sleeping
Dangerous Minds - I loved this movie. Michelle Pfeiffer was on fine form as Louanne Johnson. Never understood why it got negative reviews from critics. It was hard-hitting, powerful and emotional in places as well. No matter how many times I watch this, I never get bored of it.
To Wong Foo, Thanks For Everything Julie Newmar - movie with the late Patrick Swayze, John Leguizamo and Wesley Snipes as drag queens. They could easily pass up as women based on these looks
Toy Story - became the first ever computer animated feature film released by Disney and Pixar
Waiting To Exhale
Jack and Sarah - another film I enjoyed watching
The Thin Blue Line
Father Ted
Caroline in the City, September 21 - NBC; my personal favourite American sitcom. My review is on this blog. Love the characters, the episodes, the Caroline and Richard coupling. This show has a special place in my heart.
Due South, the Canadian/US series makes its debut on UK TV
They Think It's All Over
What A Cartoon! and Cartoon Network - back in the days before Cartoon Network turned to crap it had shows like The Flintstones and Johnny Bravo. I miss the old Cartoon Network and Boomerang channel
The Wayans Bros
The Parent' hood
In The House, April 10 - NBC; Debbie Allen's return to television was in this African - American sitcom with rapper, LL Cool J. This was the first show I watched with Debbie, and of which I later became a fan. The show wasn't the same after Debbie Allen with Jeff Wood had left the series. As the first 2 seasons were a total hoot.


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Never bend your head. Hold it high. Look the world straight in the eye.....Helen Keller
Redmond, WA (PRWEB) October 04, 2016
Edgar Cabachuela learned of the Blind Judo Foundation over a year ago after being inspired by a wrestler Peter Senerchia who goes by the ring name of Tazz. Somehow being inspired by Tazz, Edgar wanted to reach out and learn more about Judo for the blind.
He contacted Ron C. Peck, Co-Founder of the Blind Judo Foundation who learned more about Edgar and in turn contacted a longtime friend and fellow Judoka Sensei Gary Goltz. It was suggested by Goltz that the closest dojo (Judo gym) nearest Edgar's home was the Industry Sheriff's Judo Club who would welcome Edgar to their Club.
Since meeting head instructor Sensei Butch Ishisaka and fellow Instructor Sensei David Matutte, Edgar found a home to build upon his inspiration of becoming a seasoned blind Judoka (Judo athlete) with a clear vision of the 2020 Paralympic Games in Tokyo.
"Judo is a sport that requires dedication, practice, competition and hard work," according to Edgar. He continues by saying, "I have programmed Judo into my weekly and monthly schedule and I am willing to make the sacrifice to learn what is necessary to become a champion." "The Tokyo 2020 Games are not far off when it comes to learning the necessary skills required to become a candidate for the US Paralympic Judo Team," continues Edgar.
Being true to his word, Edgar enrolled in a recent West Covina Sensei Memorial Novice Judo Tournament bringing home a trophy for 2nd Place in his division. Tournaments are a must when building ones Judo skills.
Edgar also plans to attend the UCUSB (University of CA University at San Bernardino) on October 1, 2016 to support the DisAbility Sports Festival where Judo will once again be featured for those attending this annual event.
The Head Coach for the Judo event will be Sensei Walter Dean supported by Sensei Gary Goltz both supporters of the Blind Judo Foundation with a long history of working with and training the blind and visually impaired in the sport of Judo.
About us:
The Blind Judo Foundation is a nonprofit 501(c) (3) organization who introduces and trains blind and visually impaired children, young adults and our returning blind and visually impaired military men and women in the sport of Judo. Supporting our blind athletes to train, travel, attend camps and compete relies upon your tax-exempt donations.
All members of the Blind Judo Foundation are volunteers. A select few of our elite athletes go on to represent the USA as members of the US Paralympic (not to be confused with Special Olympics) Judo Team. More about the Foundation can be seen on our Facebook page. Ron C. Peck can be contacted at roncpeck(at)blindjudofoundation(dot)org or 1-425-444-8256 or Coach Willy Cahill at 1-650-589-0724


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Toddler Tuesday! Ages 3-5- Now Enrolling
Class offerings on Tuesdays 9:30am-10:10am.
Must be 3 prior to class starting. Helmets, long pants and gloves required. Skates included!
Fall XLR8
Looking to add a day of skating lessons to your child's schedule? Join us for an on ice training class, great for those students Basic 5 and Higher. 4:10pm on Thursdays!
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Conway Arena has made it easy for your to view your players game - when your on the go! Use our promo code e7b1-a739 and join today!


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7th Annual Crystal Ball Corporate Cocktail
28.641602, -81.38686)
Cause Areas
WhenFri Oct 13, 2017, 03:00 PM - 10:00 PM
WhereHoly Trinity Reception Center1217 Trinity Woods LaneMaitland, FL 32751
We are looking for volunteers to help with setup, silent auction, raffle, registration and breakdown.
Extremely fun event and we need helping hands.
Dresscode: Business Casual, Cocktail Attire
*If you are interested in gaining more volunteer hours pre event, we are looking for help in securing auction items, helping with mailings, distributing posters in the community, etc. Please call or text Layne Kauffman at 646.477.5608 if interested.
Good Match For
Requirements & Commitment
- Must be at least 18


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New York and New Jersey Attorneys
Our Attorneys
Mackiewicz & Associates, L.L.C. offers clients the responsiveness of a small firm with the resources of a large one. We provide competent, insightful, and efficient legal advice to businesses and individuals in New York and New Jersey. Our attorneys have worked in large national law firms, publicly traded companies, and smaller concerns. Because of this background, we are able to provide a level and quality of service characteristic of larger legal operations. For more information about our law firm, our attorneys, and our services, contact our New Jersey real estate attorneys.
Our Practice
We are devoted to the needs and goals of our clients. When circumstances require litigation, we are aggressive trial and appeals lawyers, not afraid to fight for our clients' rights. We also are successful arbitrators, helping our clients reach a quick resolution to their problems. We counsel and represent clients on legal issues related to a wide range of commercial and business transactions, commercial and residential real estate, and employment.
Our Clients
We represent large financial institutions, national retailers, local businesses, and individuals. To each we offer the same dedicated service, focused on achieving the client's desired outcome as economically as possible. We recognize and appreciate that the matters we handle are important to our clients and are therefore available on a 24-7 basis. For more information about our law firm, contact the New Jersey real estate attorneys of Mackiewicz & Associates, L.C.C.
Mackiewicz & Associates, L.L.C.


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17 experts advise on what's to come this year. Spoiler: Data factors big.
The Innovate Conference for the Advancement of Business Travel offered business travel executives the opportunity to articulate priorities and recommendations.
Fasthotel La Bresse Room AmenitiesFasthotel La Bresse amenities are in All rooms unless noted otherwise.
Fasthotel La Bresse On-Site Activities
Fasthotel La Bresse Guest Services


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NOTE: Sizes listed are UK. A sleek Karla Colletto one-piece swimsuit with a scoop back. Adjustable shoulder straps. Lined. 68% nylon/32% lycra spandex. Hand wash. Made in the USA. Imported fabric.


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Parc de la Ciutadella – Barcelona
I'd like to paint a picture for you all in which I am always a carefree traveler, my possessions light on my back and my feet light on the ground, dashing across this fair world of ours with nary a worry or obstacle in my way. Huzzah!
In a reality that will surprise approximately no one, that's not always how it goes.
For instance, the day we visited the Parc de la Ciutadella in Barcelona, my day did not start off on the right foot. It's hard to say why, exactly. My parents wanted to visit the Picasso Museum; but while I generally maintain at least the pretense of enjoying cultural activities, I wasn't so keen on the massive line. So Simon and I split off on our own, and that's when things went…awry.
I was a little bit grumpy, and a little bit hot. Most of all, I was a little bit tired of not being able to map out a simple itinerary that we could all agree on that would allow us to go from place to place effortlessly without ever sweating, needing a toilet, or wanting a glass of wine before noon. I mean, what's so hard about that?
You see, as much fun as it can be to get lost in an unfamiliar city, sometimes it can be plain old tiresome. Sometimes your feet hurt, and you feel silly for walking in circles, and you wish you hadn't torn up your guidebook in a frenzy of free-spirited idealism and naïveté. Hopefully, these moments are few and far between, but they happen. And when and if they do, my advice is two-fold. One: it's okay to be frustrated–give yourself a break. And two: try to hold out a little bit of faith.
In my case, we came across the Parc de la Ciutadella, and it was just what we needed. A little peace, a little greenery, a little pond with ducks and people in rowboats. Serenity! Calm! Perspective! I mean, can you look at people in rowboats and be grumpy? (Probably. I feel kind of grumpy just writing that sentence, to be honest.)
Parc de la Ciutadella was created on the site of the city's old fortress in the mid-19th century. These days, it's a popular spot for tourists and locals alike. You'll find old buildings full of character and history, surrounded by flowers and tree-lined walkways. Children play football in the shade of the branches. There are colourful murals and a variety of sculptures and fountains. With so much to see, the park is equal parts relaxing and riveting.
Now, I won't lie: there's a great deal in the park I missed. I didn't see the Cascada fountain that features in 99% of everyone else's photos, or this giant elephant. I didn't visit the zoo or the museums of zoology or geology. If a visit would be incomplete to you without these elements, a little more planning or research than I did wouldn't hurt. This, I'm afraid, is often a downside to wandering around with no earthly idea what you're doing.
Then again, it's also one of the best (and most frustrating) parts of travelling: you're never really done.
Also, there's nothing objectively wrong with wine before noon. Throw off society's arbitrary shackles and get a glass.
To get to Parc de la Ciutadella: Take metro line 1 to Arc de Triomf station. (Click for map.)


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Simple solutions grade 4 pdf lessons
1 hour ago
I also picked this up (picking up a Sprint contract in the process...glad I can expense this!) It's a Sierra Wireless 595U, a USB-based Rev A EVDO card. Having this makes the slow EDGE on the Curve not that big of a deal, as I can now fall back to this when I need to get online from a client site (or the coffee shop). I was getting over 130 KB/second sustained using it last week while at Mozart's, downloading Eclipse 3.3.


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Henry Moore
1 portrait of Henry Moore
© Karsh / Camera Press
Henry Moore
by Yousuf Karsh
bromide print, 1949
39 in. x 29 1/2 in. (990 mm x 749 mm)
Given by Yousuf Karsh, 1984
Primary Collection
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Sitterback to top
- Henry Moore (1898-1986), Sculptor. Sitter in 98 portraits, Artist of 1 portrait.
Artistback to top
- Yousuf Karsh (1908-2002), Photographer. Artist associated with 155 portraits, Sitter in 1 portrait.
This portraitback to top
The work of Henry Moore, the major British sculptor of the twentieth century, was largely based on the human form, and ranged from large-scale public commissions to small bronzes. He is also known for his air-raid shelter drawings made during the Second World War. For this portrait, Karsh photographed Moore in his studio at Hoglands, his home in Perry Green, Hertfordshire. In the background is the full-size plaster mould for his Family Group (1948-9), the first of his large works to be conceived as a bronze instead of being directly carved from the material.
Linked publicationsback to top
- Rogers, Malcolm, Camera Portraits, 1989 (accompanying the exhibition at the National Portrait Gallery from 20 October 1989 - 21 January 1990), p. 255
- Saywell, David; Simon, Jacob, Complete Illustrated Catalogue, 2004, p. 438
Events of 1949back to top
Current affairsFollowing the Republic of Ireland Act in 1948, the Irish Free State becomes the Republic of Ireland and leaves the Commonwealth. The functions previously given to the King were handed to the President of Ireland.
The Second Parliament Act diminishes the power of the House of Lords, reducing their authority to delay bills from two years to one.
Art and scienceGeorge Orwell publishes his dystopian novel, 1984. The book imagines a future where totalitarian governments rule; their power based on continual war abroad, and overwhelming propaganda and surveillance at home. With 'Big Brother' keeping a constant check on the citizens' actions and thoughts, the individual loses the faculties of free will and independent thought.
InternationalThe People's Republic of China is created after the Communist Party wins the Civil War. China became a communist country under Mao Zedong.
Cold War tensions increase as Germany is split into the democratic Federal Republic of Germany in the west (a union of the post-war British, French and American sectors), and the communist German Democratic Republic, in the east.
Tell us more back to top
Can you tell us more about this portrait? Spotted an error, information that is missing (a sitter's life dates, occupation or family relationships, or a date of portrait for example) or do you know anything that we don't know? If you have information to share please complete the form below.
If you require information from us, please use our Archive enquiry service. If you wish to license this image, please use our Rights and Images service.
Please note that we cannot provide valuations.
We digitise over 8,000 portraits a year and we cannot guarantee being able to digitise images that are not already scheduled.


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'Excellent evidence focus. Spotlight stands out and is needed.'
Steve Exall, Health and Well-Being Lead at BT, will discuss BT's approach to mental health challenges across its extensive workforce and how the company delivers a range of mental health initiatives including manager training programmes, cognitive therapy, personal resilience and mindfulness.
Dr Bridget Juniper, Director at Work & Well-Being, will provide an overview of the common causes and effects of employee mental health problems. Based on the evidence, she will outline how HR managers can develop an effective mental health programme that successfully delivers on its objectives.
'Excellent evidence focus. Spotlight stands out and is needed.'
'I really enjoyed the event, most insightful and useful.'
'I found the Spotlight session really interesting and will certainly try to come to others. '


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Dickson Animal Clinic
2940 S. New Hope Road
Gastonia, NC 28056
(704) 824-9160
Mon - Fri: 8:00AM - 5:30PM
Sat: 8:00AM - 12:00PM
Sun: Closed
Welcome to our website. Our goal at Dickson Animal Clinic is to provide the best care possible to your four-legged family members. We are a two-doctor, full-service, AAHA-certified facility established in 1960. We have 18 caring and dedicated support staff. We offer a wide range of services from wellness visits to surgery to grooming and boarding.
- Anesthesia
- Avian Practice
- Boarding
- Canine Practice
- Canine and Feline Practice
- Cardiology
- Critical Care
- Dentistry
- Dermatology
- Exotics
- Feline Practice
- Grooming
- Immunology
- Internal Medicine
- Microbiology
- Neurology
- Nutrition
- Ophthalmology
- Pathology
- Pharmacology
- Pocket Pets
- Preventative Medicine
- Radiology
- Reptile
- Surgery
- Therapeutic Laser
- English
- Most insurance accepted
- American Express
- Care Credit
- Cash
- Check
- Debit
- Discover
- Mastercard
- Visa
Sue Russell
Dr. A.M. Spencer, III
Dr. Richard Hovis
Certifications & Memberships
5 stars Ann W Featured review
Dr. Spenser and the entire staff at Dickson Animal Clinic are wonderful!
My male Samoyed, Winter, was hit by a car 2 years ago and Dr. Spenser and his team literally saved his life. They call Winter the "Miracle Dog". Truth is, this is the "Miracle Team"!
5 stars Nicole H Customer since 2015
Great service!! I was able to pick up my dogs meds easily and they were able to give her a flu vaccine without notice with no problems!!
5 stars Mary C Customer since 2015
Dr Hovis is not only the most professional vet but the most understanding one also.
Surgeon Dr. Ritter was very informative and I think his work on my Cavalier King Charles will
eliminate the pain she has had for many months now.
I would recommend Dr. Hovis to everyone. I will never use another vet as long as he is in practice
Plus his staff is the best not only with my dog but also friendly and helpful.
5 stars Cheryl R Customer since 2015
Dr. Rick Hovis is so professional, he takes as much time that is needed and is not rushed. He truly cares about the wellbeing of your pet. He explains things in a way that you can understand. The pet is his first priority. You can tell that this is not just his job but his ministry and passion. I wish Dr. Hovis could take care of me medically. I'm so grateful that I have him to take care of my pet.
5 stars Vanessa M Customer since 2015
Excellent service. Although I could not have all the procedures performed that were recommended, no one made me feel guilty nor played on my emotions to have the services provided. I appreciate this in that I feel I do the best I can for my fur babies and know that Dixon is just a phone call away should I need them.
5 stars Anonymous Verified customer
WONDERFUL I was anxious knew JoJon would be OK and she is
5 stars Matt D Customer since 2017
Absolutely wonderful staff and Dr. Hovis is great!!!!
5 stars Joy W Customer since 2014
I have always had a positive experience at Dickson Animal Clinic. The staff has consistently treated my pets with the utmost care and love. They take their time and answer my questions concerning my pets health.
5 stars Courtney J Customer since 2017
Very pleased!
5 stars Elaine D Customer since 2014
They are the best. I trust Dr. Hovis with my dog Zane and I believe he is truthful with his patients. I have been using Dickson a lot of years and that is why I continue to take my little dogs there.
The office staff if great. Will help the client in any way they can. Did have one employee that she and I did
not see eye to eye on. I was afraid she and I would soon have words with each other. I have not seen her the last several times I have brought Zane over.
5 stars Kati S Customer since 2013
As usual, the care at Dickson is top notch. My dog loves going there and gets excited to go see the vet! I can't thank Dr. Spencer, Dr. Hovis, and Dr. Whitesell enough for the quality care they've provided over the years with five different dogs and two cats. They are fantastic!
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Yu Huang Ding Hospital
Yu Huang Ding Hospital
PubMed | Binzhou Medical University and Yu Huang Ding Hospital
Type: Journal Article | Journal: Molecular medicine reports | Year: 2016
In order to determine the effect of B7H4 on the development of human hepatocellular carcinoma (HCC), the expression levels of B7H4 were evaluated using reverse transcriptionpolymerase chain reaction and flow cytometry in HL7702 and Huh7 cells. B7H4 protein expression levels were analyzed using western blotting and immunohistochemistry in HCC tissues collected from patients and from a mouse tumor model. Soluble B7H4 (sB7H4), interferon (IFN), and interleukin4 (IL4) in blood serum were assessed using ELISA in patients with HCC and mice injected with tumor cells. B7H4 was expressed in HCC cell lines, mouse tumor tissues and HCC patient tissues. However, B7H4 was not detected in HL7702 cells or normal human liver tissues. The expression level of B7H4 was positively correlated with tumornodemetastasis (TNM) stage, lymph node metastasis, and differentiation degree in patients with HCC. sB7H4 levels in blood serum samples collected from patients with HCC and tumorigenic mice were higher compared with healthy controls. Expression levels of IFN were reduced, and IL4 levels were increased in blood serum samples of patients with HCC and tumorigenic mice compared with healthy controls. sB7H4 expression levels were negatively correlated with IFN levels, and with the ratio of IFN to IL4. Additionally, sB7H4 was positively correlated with IL4 levels in mouse tumor tissues, serum samples obtained from tumorigenic mice and human HCC patients. Notably, the levels of sB7H4 and IL4 were positively correlated and IFN was negatively correlated with the TNM stage of patients with HCC. In addition, sB7H4 and IL4 expression levels increased and levels of IFN and the ratio of IFN/IL4 decreased as a function of time post tumor implantation in the mouse model. The present study determined that aberrant expression of B7H4 contributed to HCC development. B7H4 may be a potential target for therapy and diagnosis of HCC.
PubMed | Linyi Peoples Hospital, Shandong University and Yu Huang Ding Hospital
Type: Journal Article | Journal: PloS one | Year: 2015
Low shear stress (LSS) plays a critical role in the site predilection of atherosclerosis through activation of cellular mechanosensors, such as platelet endothelial cell adhesion molecule 1 (PECAM-1). Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that regulates the expression of various inflammatory cytokines. The nuclear enzyme high mobility group box 1 (HMGB1) can induce inflammation response by binding to toll-like receptor 4 (TLR4). In the present study, we aimed to investigate the role and mechanism of HMGB1 in LSS induced inflammation in human umbilical vein endothelial cells (HUVECs). HUVECs were stimulated by undisturbed shear stress (USS, 1 Pa) and LSS (0.4 Pa) in our experiments. Gene expression was inhibited by small interfering RNA (siRNA). ICAM-1 expression was regulated by LSS in a time dependent manner. LSS can induce HMGB1 translocation from nucleus to cytoplasm and release. Compared with the USS, LSS could increase the protein expression of PECAM-1 and PARP-1 as well as the secretion of TNF- and IL-1. LSS induced the translocation of HMGB1 from nucleus to cytoplasm. Inhibition of HGMB1 reduced LSS-induced inflammatory response. Inhibition of PARP-1 suppressed inflammatory response through inhibiting TLR4 expression and HMGB1 translocation. PECAM-1 inhibition reduced LSS-induced ICAM-1 expression, TNF- and IL-1 secretion, and monocytes adhesion. LSS can induce inflammatory response via PECAM-1/PARP-1/HMGB1 pathway. PARP-1 plays a fundamental role in HMGB1 translocation and TLR4 expression. Inhibition of PARP-1 may shed light on the treatment of HMGB1 involved inflammation during atherosclerosis.
Guo M.,Yantai Vocational College |
Yang A.,Yantai Vocational College |
Zhou C.,Bruker Daltonics Inc. |
Liu X.,Yu Huang Ding Hospital
Journal of Plant Interactions | Year: 2012
Salt stress is a major abiotic stress limiting the productivity and the geographical distribution of many plant species. Arabidopsis thaliana is an excellent model with rich genetic resources for modern plant biology research. To comprehensively and representatively understand salt-response mechanisms in A. thaliana, we applied the first attempt to use the most data (252 of 10,469 reviewed A. thaliana protein) from public protein database for displaying the enriched protein domains, Kyoto Encyclopedia of Genes and Genomes pathways, molecular functions, and cell localizations involved in salt-response. The data were analyzed by Database for Annotation Visualization and Integrated Discovery. Our results indicated salt-response proteins cross-talked not only with drought and temperature stress as previously reported but also with further stresses such as bacterium, light, metal ion, radiation, and wounding stress. Multiple cellular localizations under salt stress indicated proteins were versatile. In addition, 27 proteins have the characteristics with response to multiple stresses and localization in multiple places. We called it the 'space-stress' double cross-talk effects, which indicated that A. thaliana proteins dealt with salt stress and other stresses in a reciprocal economical way. An enriched bioinformatics analysis of the large data could provide clues and basis for the development of salt-response potential biomarkers for plant growth and crop productivity. © 2012 Copyright Taylor and Francis Group, LLC.
Yu X.,Yu Huang Ding Hospital |
Xing C.,Shandong University |
Pan Y.,Yu Huang Ding Hospital |
Ma H.,Yu Huang Ding Hospital |
And 2 more authors.
Acta Biochimica et Biophysica Sinica | Year: 2012
Atherosclerosis, a multifactorial chronic inflammatory response, is closely associated with oxidatively modified low-density lipoprotein (ox-LDL). High-mobility group box 1 (HMGB1) is a DNA-binding protein, which upon release from cells exhibits potent inflammatory action. Insulin-like growth factor 1 (IGF-1) can elicit a repertoire of cellular responses including proliferation and anti-apoptosis. However, the role of IGF-1 in inflammation is still unclear. In the present study, we aimed to investigate the role of IGF-1 in inflammation and the underlying mechanism. Human aortic endothelial cells were stimulated by ox-LDL (50 μg/ml) to induce inflammation. The expression of intercellular adhesion molecule 1 (ICAM-1) was assessed by western blot analysis and immunofluorescence. The release of HMGB1 was determined by enzyme-linked immunosorbent assay. IGF-1 receptor (IGF-1R) expression was assessed by reverse transcription-polymerase chain reaction and western blot analysis. IGF-1R phosphorylation was determined by western blot analysis. Ox-LDL stimulation reduced IGF-1R mRNA and protein expression but increased HMGB1 release. IGF-1 treatment decreased ox-LDL-induced ICAM-1 expression potentially through reducing HMGB1 release, while picropodophyllin, an IGF-1R specific inhibitor, increased the inflammatory response. In conclusion, IGF-1 can alleviate ox-LDL-induced inflammation by reducing HMGB1 release, suggesting an unexpected beneficial role of IGF-1 in inflammatory disease. © 2012 The Author.
Peng X.,Yu Huang Ding Hospital
Acta biochimica et biophysica Sinica | Year: 2012
Atherosclerosis is a chronic inflammatory disease. Toll-like receptor 4 (TLR4) is an important signaling receptor and plays a critical role in the inflammatory response. Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that can regulate the expression of various inflammatory genes. In this study, we investigated the role and the underlying mechanisms of PARP1 on lipopolysaccharide (LPS)-induced inflammation in human aortic endothelial cells. Compared with the control, LPS stimulation increased the protein expression of TLR4 and PARP1. TLR4 inhibition reduced LPS-induced upregulation of inducible nitric oxide synthase (iNOS) and ICAM-1 as well as PARP1. Nuclear factor κB (NF-κB) inhibition decreased ICAM-1 and iNOS expression. Inhibition of PARP1 decreased protein expression of inflammatory cytokines induced by LPS stimulation, probably through preventing NF-κB nuclear translocation. Our study demonstrated that LPS increased ICAM-1 and iNOS expression via TLR4/PARP1/NF-κB pathway. PARP1 might be an indispensable factor in TLR4-mediated inflammation after LPS stimulation. PARP1 inhibition might shed light on the treatment of LPS-induced inflammatory cytokines expression during atherosclerosis.
Liu F.-J.,Yu Huang Ding Hospital |
Wang H.-Y.,Yu Huang Ding Hospital |
Li J.-Y.,Yu Huang Ding Hospital
Molecular Biology Reports | Year: 2012
The testis is the male gonad responsible for spermatogenesis and steroidogenesis. Much remains to be known about the control of these events. In this study, we performed a new bioinformatic enrichment analysis of human testicular proteins selected from a protein database. Integrated function and pathway analyses were performed by Database for Annotation, Visualization and Integrated Discovery and Ingenuity Pathway Analysis programmes, and significant features were found to be clustered. Proteinmembrane organization and gene density on chromosomes were analyzed and discussed. The analysis could provide a basis for the understanding of testicular physiology and function, and facilitating biological interpretation of testicular functions in a network context. © Springer Science+Business Media B.V. 2011.
Li J.,Yu Huang Ding Hospital |
Li J.,Yantai University |
Liu F.,Yu Huang Ding Hospital |
Wang H.,Yu Huang Ding Hospital |
And 9 more authors.
Molecular and Cellular Proteomics | Year: 2010
The mammalian spermatozoon has many cellular compartments, such as head and tail, permitting it to interact with the female reproductive tract and fertilize the egg. It acquires this fertilizing potential during transit through the epididymis, which secretes proteins that coat different sperm domains. Optimal levels of these proteins provide the spermatozoon with its ability to move to, bind to, fuse with, and penetrate the egg; otherwise male infertility results. As few human epididymal proteins have been characterized, this work was performed to generate a database of human epididymal sperm-located proteins involved in maturation. Two-dimensional gel electrophoresis of epididymal tissue and luminal fluid proteins, followed by identification using MALDI-TOF/MS or MALDI-TOF/TOF, revealed over a thousand spots in gels comprising 745 abundant nonstructural proteins, 408 in luminal fluids, of which 207 were present on spermatozoa. Antibodies raised to 619 recombinant or synthetic peptides, used in Western blots, histological sections, and washed sperm preparations to confirm antibody quality and protein expression, indicated their regional location in the epididymal epithelium and highly specific locations on washed functional spermatozoa. Sperm function tests suggested the role of some proteins in motility and protection against oxidative attack. A large database of these proteins, characterized by size, pI, chromosomal location, and function, was given a unified terminology reflecting their sperm domain location. These novel, secreted human epididymal proteins are potential targets for a posttesticular contraceptive acting to provide rapid, reversible, functional sterility in men and they are also biomarkers that could be used in noninvasive assessments of male fertility. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
Liu F.,Yu Huang Ding Hospital |
Wang H.,Yu Huang Ding Hospital |
Li J.,Yu Huang Ding Hospital
BMB Reports | Year: 2011
The testis is major male gonad responsible for spermatogenesis and steroidogenesis. Much knowledge is still remained to be learned about the control of these events. In this study, we performed a comprehensive bioinformatics analysis on 1,196 mouse testis proteins screened from public protein database. Integrated function and pathway analysis were performed through Database for Annotation, Visualization and Integrated Discovery (DAVID) and ingenuity Pathway Analysis (IPA), and significant features were clustered. Protein membrane organization and gene density on chromosomes were analyzed and discussed. The enriched bioinformatics analysis could provide clues and basis to the development of diagnostic markers and therapeutic targets for infertility and male contraception.
Wang J.,Shandong University |
Wang J.,Yu Huang Ding Hospital |
Liu L.,Yu Huang Ding Hospital |
Xia Y.,Yu Huang Ding Hospital |
Wu D.,Shandong University
Acta Biochimica et Biophysica Sinica | Year: 2014
In addition to biochemical stimuli, physical forces also play a critical role in regulating the structure, function, and metabolism of the lung. Hyperstretch can induce the inflammatory responses in asthma, but the mechanism remains unclear. Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that can regulate a variety of inflammatory cytokines expression. In the present study, we aimed to investigate the role and mechanism of PARP-1 in mechanical stretch-induced inflammation in human bronchial epithelial cells (HBEpiCs). HBEpiCs were simulated by mechanical stretch and cells under static were used as the control. PARP-1 expression was interfered by small interfering RNA. Oxidative stress was evaluated by DHE staining. DNA damage was assessed by comet assay. The results showed that interleukin-8 (IL-8) and vascular cell adhesion molecule-1 (VCAM-1) expression were regulated by hyperstretch in a time-dependent manner. Hyperstretch could increase PARP-1 expression and activity by inducing superoxide production and DNA damage. Silencing of PARP-1 attenuated hyperstretch-induced IL-8 and VCAM-1 up-regulation as well as monocytes adhesion, which were related to the inhibition of nuclear factor-kappa B (NF-κB) translocation. Our study showed that hyperstretch could induce inflammatory response and superoxide production as well as DNA damage in HBEpiCs. PARP-1 silencing decreased IL-8 and VCAM-1 expression, partly through inhibition of NF-κB translocation. PARP-1 played a fundamental role in hyperstretch-induced inflammation. PARP-1 silencing could be used as a potential therapeutic approach to reverse bronchial epithelial inflammation in asthma. © 2014 The Author 2014.
Dong M.,Shandong University |
Zhong L.,Yu Huang Ding Hospital |
Chen W.Q.,Shandong University |
Ji X.P.,Shandong University |
And 8 more authors.
PLoS ONE | Year: 2012
Enhanced matrix metalloproteinases (MMPs) activity is implicated in the process of atherosclerotic plaque instability. We hypothesized that doxycycline, a broad MMPs inhibitor, was as effective as simvastatin in reducing the incidence of plaque disruption. Thirty rabbits underwent aortic balloon injury and were fed a high-fat diet for 20 weeks. At the end of week 8, the rabbits were divided into three groups for 12-week treatment: a doxycycline-treated group that received oral doxycycline at a dose of 10 mg/kg/d, a simvastatin-treated group that received oral simvastatin at a dose of 5 mg/kg/d, and a control group that received no treatment. At the end of week 20, pharmacological triggering was performed to induce plaque rupture. Biochemical, ultrasonographic, pathologic, immunohistochemical and mRNA expression studies were performed. The results showed that oral administration of doxycycline resulted in a significant increase in the thickness of the fibrous cap of the aortic plaque whereas there was a substantial reduction of MMPs expression, local and systemic inflammation, and aortic plaque vulnerability. The incidence of plaque rupture with either treatment (0% for both) was significantly lower than that for controls (56.0%, P<0.05). There was no significant difference between doxycycline-treated group and simvastatin-treated group in any serological, ultrasonographic, pathologic, immunohistochemical and mRNA expression measurement except for the serum lipid levels that were higher with doxycycline than with simvastatin treatment. In conclusion, doxycycline at a common antimicrobial dose stabilizes atherosclerotic lesions via inhibiting matrix metalloproteinases and attenuating inflammation in a rabbit model of vulnerable plaque. These effects were similar to a large dose of simvastatin and independent of serum lipid levels. © 2012 Dong et al.


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SDA-McAfee report says Israel subjected to 1,000 cyber attacks per minute, which it successfully tackles; awards it 4.5 stars – higher score than US.
The report reviewed 23 countries. Israel topped the report alongside Sweden and Finland; the United States, Britain, Germany and France scored four starts each, Canada, Australia and Japan received 3.5 stars, China and Russia were given three stars, Brazil and India got 2.5 starts and Mexico closed off the list with only two stars.
A recent report by the Security and Defense Agenda (SDA) and McAfee concluded that Israel enjoys significant cyber-readiness.
The Brussels-based SDA is a specialist cyber-security and defense think-tank. McAfee, an Intel subsidi
By: aydeo
In: Other News
Tags: Israel, Sweden, Finland, SDA-McAfee report, cyber-readiness
Views: 2098 | Comments: 8 | Votes: 0 | Favorites: 0 | Shared: 0 | Updates: 0 | Times used in channels: 2
- Comment of user 'MB-UK' has been deleted by author (after account deletion)!
Too many kiddish and criminals from Saudia Arabia, Algeria and Russia using childlish Trojans and SQL injection Denial of service, Identity theft of innocents peoples and they think they're genius.
Would be savant if someone fuck the super computers with Perl, Pascal ana Ada language.
Crackers are the biggest jokes.
Posted Feb-1-2012 By
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Comment of user 'htos1' has been deleted by author (after account deletion)!
OK then, I'm convinced now. I support SOPA and PIPA because I need to feel safe from the cyber evil dowers...
Posted Feb-1-2012 By
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Their registered address on file is 5208 Peck Rd, El Monte, CA 91732, - , CA, .
Obert Trading Inc. currently have 1 Officers / Partners: Baochang Dong, and there are no other known Officers / partners in the company except these 1 officials at this time.
Obert Trading Inc. is currently in Active Status.
|Company Name
|Obert Trading Inc.
|Document Number
|Registration Date
|Last Event
|Statement Filed
|5208 Peck Rd, El Monte, CA 91732, - , CA,
|Company Status


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Four Years! - One of my new favorite things: Hak's I searched their website and all of the products listed are Gluten Free except for the Hak's Thai Chili Tamarid Sauce....
1 year ago
ROTFL! That was still hilarious. Bravo!
We're very grateful he makes for one ugly woman. LOL
Oh Jenne, I have no words, which is probably best, since I'm laughing too hard to say anything anyway! Bwah!