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The prognosis for diffuse infiltrating pontine gliomas (DIPG) remains extremely poor, with the majority of patients surviving less than 2 years. Here, we have adapted standard xenograft techniques to study glioma growth in the mouse brainstem, and have utilized the mouse model for studying a relevant therapeutic for treating DIPGs. bioluminescence imaging monitoring revealed a progressive increase in signal following the injection of either of two tumor cell types into the brainstem. Mice with orthotopic GS2 tumors, and receiving a single 100 mg/kg dose of temozolomide showed a lengthy period of decreased tumor luminescence, with substantially increased survival relative to untreated mice (P<0.001). A small molecule inhibitor that targets cdk4/6 was used to test AM-38 brainstem xenograft response to treatment. Drug treatment resulted in delayed tumor growth, and significantly extended survival. Our results demonstrate the feasibility of using an orthotopic brainstem tumor model in athymic mice, and for application to testing therapeutic agents in treating DIPG.
Brainstem tumors arise predominantly in the pediatric population where they constitute up to 20% of childhood brain tumors [1, 2]. The majority of brainstem tumors are diffuse infiltrating pontine gliomas (DIPG), and patients with these tumors rarely survive beyond 2 years from initial diagnosis [3]. Although many chemotherapy and radiation therapy regimens have been used to treat DIPGs, none has proved successful in conferring a survival advantage, compared to radiation alone [4]. Factors which contribute to the dismal prognosis of patients with DIPG include their anatomic location which prevents meaningful surgical resection, and their invasive dissemination [5].
Progress has been made in the treatment of high grade supratentorial glioma using targeted anticancer agents [6–10]. The applicability of anatomically accurate model systems to test the efficacy of therapeutic agents has also been demonstrated [2]. We recently reported the development of an orthotopic brainstem tumor model in athymic rats using GS2 glioma cells [11]. However, there are limitations of the rat model, primarily associated with the high expense of housing, imaging cost, and acquisition of sufficient drug for testing therapy-response hypotheses.
Using human GS2 and AM-38 human glioma cells, we report the development of an orthotopic brainstem tumor model in athymic mice. In addition to determining the technical parameters required for implantation of tumor cells into the mouse brainstem, we also tested the applicability of this model system as platform for therapeutic testing of new agents. We examined the effect of a relatively non-specific agent such as temozolomide (TMZ), as well as the small molecule inhibitor of CDK 4/6, PD-0332991, with the latter being effective against human DIPG cell growth in vitro.
GS2 human glioma cells were obtained from Manfred Westphal (Hamburg, Germany), and maintained as a neurosphere culture in Dulbecco's modified Eagle's medium High Glucose (DME H-12), 100 U/ml penicillin (Invitrogen), B-27 supplement (50×) without vitamin A (Invitrogen), N-2 supplement (100×) (Invitrogen), 20 μg/ml EGF (Calbiochem) and 20 ng/ml FGF (Sigma, St Louis, MO, USA).
AM-38 human glioma cell were obtained from Japan Health Sciences Foundation Health Science Research Resources Bank [12]. AM-38 cells were grown as adherent monolayer cultures in Dulbecco's modified Eagle's medium High Glucose (DME H-21), without Phenol Red (UCSF Cell Culture Facility), 100 U/ml penicillin and 100 μg/ml streptomycin (Invitrogen).
Cells were transduced with a lentiviral vector containing firefly luciferase (FL) under the control of the spleen focus forming virus (SFFV) promoter. Lentiviral vectors were generated by transfection of 293T cells with plasmids encoding the vesicular stomatitis virus G envelope, gagpol, and Fluc genes. Conditioned medium containing viral vectors were harvested 48 h post transfection, filtered (0.45 mm), and frozen until use. Cells were screened for transfection efficiency by treatment with luciferine (D-luciferin potassium salt, 150 mg/kg, Gold Biotechnology, St Louis, MO) in vitro and examination by a Xenogen IVIS Lumina System (Xenogen Corp., Alameda, CA). More than 80% of cells were transfected [11].
Five-week-old female athymic mice were (Simonsen Laboratory, Gilroy, CA) maintained in a temperature and light controlled animal facility under pathogen-free conditions in air-filtered cages and received food and water. Mouse weights were recorded daily. If an animal's weight dropped 15% below baseline, treatment was withheld until the weight recovered. Animals were sacrificed if they became symptomatic from brainstem tumor burden according to the protocol. All animal protocols were approved by the UCSF Institutional Animal Care and Use Committee.
Localization of tumor cell implantation in the pons was determined by initially using blue dye in cadaveric mice. Prior to surgery mice were anesthetized using an intraperitoneal injection of 100 mg/kg of ketamine and 10 mg/kg of xylazine. The skull of the mouse was exposed and a small opening was made using 25 gauge needle (PrecisionGude) 1.5 mm to the right of midline, posterior to the lambdoid suture. GS2 FL or Am38 FL cells were injected into the pons (5.0 mm depth from the inner table of the skull) with a 26 gauge Hamilton syringe (Hamilton Company, Nevada, USA). A total of 1.0 × 106 GS2 FL cells or 1.0 × 104 Am38 FL cells in a volume of 0.5 μL were injected using a free hand technique [13].
Athymic mice implanted with luciferase-modified GS2 or AM-38 glioblastoma cells were randomized to vehicle control (OraPlus, for TMZ, 50 mM sodium lactate, pH 4, for PD-0332991) or TMZ treatment (Temodar, Schering-Plough, Kenilworth, NJ) or PD treatment (PD-0332991, Pfizer Inc, NY) groups. For GS2 glioma xenografts, the treatment group (n = 5) received a daily dose of 100 mg/kg of TMZ by oral gavage on day 30. For AM-38 glioblastoma xenografts, the treatment group received a daily dose of 150 mg/kg PD-0332991 by oral gavage for 12 consecutive days. All mice were monitored every day for the development of symptoms related to tumor burden and twice weekly by bioluminescence imaging (BLI) (see below). Mice were euthanized when they exhibited symptoms indicative of significant compromise to neurological function. Animal survival was defined as the time euthanasia was performed.
In vivo BLI was performed with the Xenogen IVIS Lumina System (Xenogen Corp., Alameda, California) coupled to the data-acquisition Living-Image software (Xenogen Corp., Alameda, California) [14, 15]. Mice were anesthetized with 100 mg/kg of ketamine and 10 mg/kg of xylazine and BLI was performed 10 min after intraperitoneal injection of 100 μl D-Luciferin (150 mg/kg) (Gold Biotechnology, St. Louis, Missouri). All mice were imaged 1 or 2 times per week. Signal intensity was quantified within a region of interest over the heads of mice, as defined by the Living-Image software. To facilitate comparison of growth rates, each mouse's luminescence readings were normalized against its own luminescence reading at the day of last BLI before initiation of therapy, thereby allowing each mouse to serve as its own control. Previously published data using these techniques documented a strong correlation between measured bioluminescence, tumor burden, and animal survival [11].
All rodent tissues were fixed in phosphate-buffered 10% formalin dehydrated by graded ethanol, and then embedded in wax (Paraplast Plus, McCormick Scientific, St. Louis, Missouri). Sections 5 μm thick were cut from embedded mouse brainstem samples. Hematoxylin and eosin (H&E) staining was performed according to standard procedures. For immunohistochemistry, Mib-1 labeling and Caspase-3 stained with primary antibody by UCSF IHC and molecular pathology core facility. After relative quantification of these staining, representative slides were recorded. Positive cells were determined by EVOS microscope (AMG (Advanced Microscopy Group), WA, USA) and the numbers of positive cells were countered in four high-power fields (40× magnification) from each mouse, and mean values determined.
The Kaplan–Meier estimator was used to generate the survival curves [16] and differences between survival curves were calculated using a log-rank test. Differences between the two groups with Mib-1 and Caspase 3 positive cells were compared using a student's t test [17] using Prism software (GraphPad Software, San Diego, CA, USA).
There are technical challenges associated with implantation of tumor cells into the rodent brainstem. The brainstem itself is compact in size and rapid, procedure-associated development of symptoms, such as torticollis and nystagmus, necessitate animal euthanasia. In our model system, BLI monitoring revealed successful tumor cell engraftment in all animals, and progressive tumor growth in each case. Implanted tumors demonstrated logarithmic growth subsequent to day 7 after implantation, at which time injected mice were asymptomatic. Animals were euthanized once symptoms described above developed. The median survival, as defined by the onset of symptoms, was 54 days after implantation, with a range of 50–62 days.
In a time course study used to evaluate accuracy of monitoring tumor growth by BLI, mice were euthanized at pre-determined time points, and immediately following BLI (Fig. 1a), with whole brains removed, processed, and cut to obtain serial cross sections in the axial plane. Luminescence signals detected in right pons on day 20, 30 and 40 indicated progressive tumor growth (Fig. 1a), with GS2 tumor easily visible in brain by day 30 post tumor cell injection, and showing an increasing degree of brain infiltration after day 40. On day 50, the implanted tumor was seen within the right pons and in some cases, with extension over the surface of the brainstem (Fig. 1b).
We next measured GS2 brainstem xenograft response to TMZ by BLI monitoring. Mice were randomized into vehicle only and TMZ treatment groups on day 30 after tumor implantation, with the TMZ group receiving a single 100 mg/kg dose of TMZ on day 31. The normalized luminescence plot for the control group showed progressively increasing luminescence until mice developed neurological symptoms indicative of a moribund condition. In comparison to the control group, the luminescence signal in mice receiving TMZ treatment decreased and remained low until day 80 following implantation (Fig. 2a–c). The median survival of mice treated with TMZ was significantly extended relative to controls (P = 0.0006; Fig. 2b).
The effect of therapy on tumor cell proliferation was additionally assessed using MIB-1 staining. As expected, there was a significant reduction in MIB-1 positive staining in the TMZ-treated mice as compared to the control group (**P<0.001, Fig. 3a). In mice that were sacrificed after TMZ treatment, caspase 3 staining was used to evaluate the effect of treatment on GS2 tumor cell apoptosis. The number of caspase 3 positive cells were significantly increased in mice treated with TMZ (**P<0.001, Fig. 3b).
A primary cell line derived from a patient with a DIPG that we have characterized for genomic alterations (manuscript in preparation), was determined to have homozygous deletion of CDKN2A, which encodes p16 (Fig. 4). In addition, we have shown that a cdk4/6 inhibitor, PD0332991, is effective in slowing the growth of supratentorial malignant xenografts harboring activated cdk4/6 by virtue of homozygous inactivation of p16. The glioblastoma cell line AM-38, that also lacks p16, showed significantly reduced proliferation in vitro when treated with PD0332991 (unpublished data). AM-38 was used to establish brainstem tumors in athymic mice to test the in vivo efficacy of PD0332991 in association with DIPG anatomic modeling. Mice receiving PD0332991 treatment experienced reduced tumor growth and extended survival relative to control mice (Fig. 5).
In this study, we describe the development of a mouse model for brainstem human glioma that has been developed to facilitate the pre-clinical testing of new therapeutic agents for treating DIPG. Previously, we demonstrated the feasibility of implanting and monitoring an brainstem glioma xenografts in rats [11]. However, the rat model has limitations, primarily associated with expense, including purchase, housing, imaging, and acquiring sufficient drug to conduct therapeutic tests.
Very few studies have used an orthotopic xenograft model for examining brainstem glioma growth. The mouse pons is very small, and inaccurate targeting of implanted cells results in extension of tumor growth outside the brainstem. Furthermore, inaccurate tumor cell injection may lead to increased procedural mortality. Here, we used two established human cell lines, GS2 and AM-38, to establish brainstem xenografts in mice. We had previously observed that each cell line grows invasively when propagated in the supratentorial compartment, and our results demonstrate their progressive, infiltrative growth in the mouse pons. A limitation of our experimental system is that both GS2 and AM-38 are derived from adult high grade astrocytomas, and not from pediatric DIPGs. In the current study we utilized a DIPG cell line (SF7761) for testing therapeutic response in vitro. Unfortunately this cell source is only weakly tumorigenic, and produces very slow growing tumors in athymic mice that are not compatible with therapeutic testing. Consequently we used the two GBM cell lines for in vivo anatomic modeling and investigating brainstem tumor response to therapy.
TMZ is commonly used to treat supratentorial high grade tumors in a clinical setting but is not generally effective for patients with DIPG. However, TMZ is a useful tool to study the response of intracranial tumors since most cell lines show some sensitivity to this drug. TMZ reduced the luminescence of GS2 brainstem tumors, and increased animal survival. The use of BLI allows quantitative measurement of tumor growth, which correlates well with tumor volume. From a practical perspective, the per animal cost of mouse bioluminescence imaging is approximately tenfold less than for rats.
We also chose to study an enzymatically targeted small molecule inhibitor in our model system. It has been reported that the activation of cyclin-dependent kinases 4/6 (cdk4/6) is among the most common aberrations found in human cancer [18], and occurs in the majority of glioblastoma [19–21].Arecent report showed that a CDK4/6 inhibitor was effective in supratentorial GBM rodent model [12]. We examined whether PD0332991 (an inhibitor of CDK4/6) would extend survival in mice with brainstem xenografts by reducing tumor growth rate. For these studies, we used glioblastoma cell line AM-38 because it has homozygous deletion of p16, as is the case for the DIPG cell line we have established and tested for in vitro sensitivty to PD0332991. BLI and survival of mice with AM-38 brainstem tumors indicated that there was antitumor activity of PD0332991.
In summary, our results, along with those from other groups, demonstrate the feasibility of using an orthotopic brainstem model for pre-clinical therapeutic testing in mice [22–26]. The development of a panel of tumorigenic cell sources from DIPG patients, for use in a brainstem xenograft context, will further advance this approach for identifying effective therapeutics for treating pediatric patients afflicted with this cancer.
This work was supported by the Pediatric Brain Tumor Foundation Institute Award to the Brain Tumor Research Center at UCSF.
Conflict of interest None.
Yasuyuki Aoki, Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave., Rm M779, San Francisco, CA 94143-0112, USA.
Rintaro Hashizume, Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave., Rm M779, San Francisco, CA 94143-0112, USA.
Tomoko Ozawa, Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave., Rm M779, San Francisco, CA 94143-0112, USA.
Anu Banerjee, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Michael Prados, Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave., Rm M779, San Francisco, CA 94143-0112, USA.
C. David James, Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave., Rm M779, San Francisco, CA 94143-0112, USA.
Nalin Gupta, Department of Neurological Surgery and Brain Tumor Research Center, University of California San Francisco, 505 Parnassus Ave., Rm M779, San Francisco, CA 94143-0112, USA. Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Kimmer has been an UBER fan of SNL since I was old enough to stay up and watch. The 1975 cast of course will remain the best and Gilda Radner was always my favorite Not-Ready-for-Prime-Time-Player. Her unique characters and sense of timing always had me rolling on the floor. Remember Jenny Miller? Lisa Lubner? Roseann Roseanna Danna? Followed closely by John Belushi, Chevy Chase and Dan Akroyd.
The Weekend Update will always be a classic comedy sketch and remains just as funny today albeit a bit too politically correct. After all who could ever top "Jane you ignorant slut" ? They just don't do that anymore on TV.
SNL has been on TV now for 35 years. So hard to believe, right? I think my newest favorite cast member would have to be Kristen Wiig. She does some great imitations, as well as her character Penelope and The Assholes.
SNL has made some common names even more appreciated. I know I learned to love Steve Martin, Alec Baldwin and Justin Timberlake from their continuous skits on SNL. But I think the best part used to be that SNL gave up-n-coming newbie musical acts a once in a lifetime shot on national TV.
I remember the first time I saw Cindi Lauper as the musical guest, as a die-hard, heavy metal, head-banger, I would have bet cold hard cash that her rendition of Girls Just Wanna Have Fun, was a comic skit. Lo and behold she became the darling of MTV with her outlandish appearance (and true talent under all that glitter).
Last night, Taylor Swift was the host and musical guest. I know she's the new cool thing for tweens, but the girl cannot sing! She is tone deaf! Am I the only one whose ears bleed when she attempts to sing outloud? For the love of Pete! Please stop boosting this girl's ego! REALLY?!
I hope SNL goes back to giving newbies a shot. It's more interesting and usually the talent is real and justified. Also, while we're at it, can they just go ahead and bring back the Bass-o-Matic, too?

subset: commoncrawl


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Monday to Friday 08:30 - 12:00 13:30 - 16:30
Bake a cake full of love with the innovative I Love Cakes Heart Cake Mould.
This cherry-red cake pan produces a beautiful, generously-sized cake with deep, ruffled edges. But when you cut the cake, you create six perfect individual heart-shaped slices. No more fiddling about with biscuit cutters or tiny tins to create personal cakes. Everyone gets their own with this clever mold!
The I Love Cakes Heart Cake Mould is a cute idea for a festive family dessert on Valentine's Day. Or bake a big birthday cake and let every kid feel a bit special when they get a piece. You can even share the sugary love using this mould to create an unusual and pretty wedding cake for an intimate celebration. At 30 centimeters, this pan makes quite a large cake, so you could cut smaller slices to serve lots of people without the heart shape. The whole cake looks stunning on its own with its deeply fluted sides. The I Love Cakes Heart Cake Mould is the perfect gift for a mate who loves creative baking.


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This stylish and comfortable 2 bedroom house is located on a quiet street in trendy Leslieville within walking distance of great shops and restaurants. Enjoy a custom kitchen, two full bathrooms, outdoor space, and easy access to 24-hour transit.
El alojamiento
This beautifully appointed space will make you feel at home and at ease as soon as you step through the door. With a custom open tread staircase and unique design features, there is striking attention to detail throughout the home. Spotless and cozy with an industrial feel, the house features exposed brick, hardwood flooring throughout, a glass and steel bannister, and a skylight for added daylight. Two full shower/baths and one half bath make stays with multiple guests hassle-free. Steps away from 24-hour transit to take you west to the downtown area or east to the beach, and walking distance from great shops and boutiques. Perfect for stays with friends and family, this house is comfortable, convenient, and fully equipped with all the comforts of home.
Servicios y zonas comunes
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Atención a los huéspedes
I am available as much or as little as you need. I've lived in the area for years and love to share my tips on what I think are the gems of the neighbourhood. I'm a big fan of hosting and getting to know different guests, but I get that sometimes when you're travelling you just want to be left to your own devices. Either way, whatever works for you works for me.
Otros aspectos destacables
Please note that the security deposit is not really a deposit at all: it is the maximum amount a host can request from a guest in the event of damage to the property after their stay has ended. My "security deposit" is particularly high to insure that damages to the property can be covered (I have had some very unfortunate guest experiences), but it is not a charge that is added to your card at the time of booking. In fact, assuming there are no damages to the property, it will never be charged at all.
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I take great pride in my house and great pride in hosting. I ask that my guests show the same respect for me and my home as I show for them. Good vibes only. No pets allowed and no smoking anywhere inside the house. I am committed to making sure that my guests' stays are comfortable and enjoyable and I am always appreciative when they treat the home with the same degree of consideration.
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i'm a born, bred and raised torontonian. i love travelling and having adventures everywhere, but i also really love my city. my best trips have always involved great places to stay and great hosts. i love hosting and i hope my place will make your trip a great one, too.


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Crossing the Border for PEPY Empowering Youth: A Reflection
Monday, 11 January 2016
by Megan Skinner
Two countries, two big cities, two bikes and two dedicated cyclists: Cho and Joe's fundraising bike ride from Phnom Penh to Vietnam was more than just an adventure – it was a chance to learn, experience and reflect on the . . . Read More.


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tempting to ghost, but that's not the right thing to do. is waiting until he finishes a major project fair either though? he was talking about taking some time to figure out if we're right for each other after I get back and . . . I didn't know what to say.
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Here are some shows to check out around the Champaign-Urbana area in the month of April:
Ghost Track Featured Show
DIY Venue
Undercut Collective's 1st Birthday ft. T.R.U.T.H
Indi Go Artist Co-op
7 p.m. | $5 | Friday, April 24
Saskia Bakker has been doing some inspiring work with CU's youth community over the past year. The high schooler's Undercut Collective has thrown shows throughout the year, highlighting local bands and focusing on showcasing high school bands from the area. Her latest show will celebrate her project's first birthday and features Champaign rapper T.R.U.T.H, along with an open mic.
Tigerbeat, Penny Horses
Mike N Molly's
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An alt-country throw down takes place in downtown Champaign on April 24. Tigerbeat has been pretty inactive over the past few months, but returns to bring their slow-jams to the Champaign crowd. Penny Horses is the most exciting act of the night, having been working on new music over the past few months. The band brings a lo-fi alt-country style that is swinging into town at the perfect time, coming off The Fights' fantastic 2014 country crusade.
Canopy Club
9 p.m. | $3 | Wednesday, April 29
The boys from Bones Jugs N Harmony play their third Champaign-Urbana show in 11 days when they stop by the Canopy Club in Urbana for a late night show. The band has spent most of the year touring off their 2014 release Party's in the Kitchen. Wednesday night's show is part of the Summer Camp Wednesdays at Canopy Club, featuring bands playing at the Illinois festival in late May. Oh, and there's FREE pizza from 9 p.m. – 11 p.m. at Wednesday night's show.


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Heat vs Thunder Free Pick
February 14, 2013
Tonight the Miami Heat visit the Oklahoma City Thunder for an East versus West matchup before both teams and the rest of the league take a four day hiatus for the All Star festivities.
The Heat leads the Eastern Conference with a record of 35-14 straight up and 25-24 against the spread. Oklahoma City trails only the San Antonio Spurs for the best record in the Western Conference and the NBA at 39-13 straight up and 31-20-1 against the spread.
Miami enters this game on fire having won six straight games and 8 of their past 10. However, the Thunder has one of the best records at home, as they have won 23 of their 26 home games this season. LeBron James however, will have something to say about tonight's outcome. James is making his claim to the MVP award with his fine play. He set an NBA record this week by scoring a minimum of 30 points while shooting at least 60% from the field in each of his past six games.
Last season the Heat defeated the Thunder in five games to win the NBA Championship and this will be the first time the two teams have played in Oklahoma City since Miami defeated the Thunder in game two of the Finals and then won three straight in Miami to win the title.
On Christmas Day this season, the Heat defeated Oklahoma City in the only matchup head to head between the two teams this season.
To receive this article and sent to your mobile device down load our app and hyperlink it here.
Oklahoma City had won four consecutive games by 20 points or more until Tuesday night when the Utah Jazz defeated the Thunder in Utah. Durant has led the league in scoring for three straight seasons and this season has career best averages in six statistical categories.
Tonight's line has the Thunder as a favorite at home by 4 ½ points with the total for the over under set at 205. Smart money is taking Miami plus the points and the total to cash out on the over.
To bet on this game or any other sporting event click here http://www.sportsbookadvisor.com/recommended-sportsbooks.htm to visit one of our recommended sports books.


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Rose Tattoo
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Rose Tattoo is an Australian blues/hard rock band, led by Angry Anderson and slide guitarist Peter Wells. Among their best known songs are "We Can't Be Beaten", "Scarred for Life" and "Bad Boy for Love" (co-written by Ian Rilen.) Their first four albums were produced by Harry Vanda and George Young who also worked with AC/DC. Along with AC/DC and The Angels, Rose Tattoo helped establish a blues rock sound copied by a number of bands in Australia.Read More...
Read more on Last.fm. User-contributed text is available under the Creative Commons By-SA License; additional terms may apply.
Top SongsTotal plays on Last.fm over the last 6 months
- Rock 'n' Roll Outlaw - 68,180 plays
- Nice Boys - 67,683 plays
- Bad Boy For Love - 35,402 plays
- One Of The Boys - 26,649 plays
- We Can't Be Beaten - 24,462 plays
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- Tramp - 15,822 plays
- Scarred For Life - 15,751 plays
- Astra Wally - 14,694 plays
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John and I (Mickey) would like to thank you for being a part of the Distortion Brothers launch. We are very fortunate to have received so much support, interest, patronage, advice, and good will from our customers, wives, friends, family, suppliers, and peers. Many of you are truly invested in Distortion Brothers and we have deep gratitude for you, our ohana.
There is so much more to come in the next weeks and months for the Distortion Brothers Guitar Shop. We can only imagine what next Thanksgiving Day will have in store.
As a young, small company, we partner with others in hopes of offering the best products and services to our customers.
By listening to our customers and constantly innovating, we have built a way of doing business that we are very proud of. We strive to always provide you excellent customer service as well offer you free shipping, special financing, instrument insurance, layaway program, and complimentary setup.


text: Come by =PR= Fairfax on Monday, May 22 at 6:30 PM for a fun run fueled by Nathan! With the temperatures rising, the importance of fueling before, during, and after your run is rising just as quickly! Our Nathan rep will be here before and after the run to discuss the importance of hydration during these warmer months and how to make sure you stay hydrated during all aspects of your training and everyday life! We will have Nathan products to demo during the run to see how everything feels first hand. After the run, we will also be dishing out s'mores to participants for recovery!


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To the pages of Reg Atkinson Photography.
Within you will find a small portfolio of images covering many areas of photography incuding a few portrait images of friends and family.
We hope you enjoy your visit and please feel free to bookmark the page as we always have something new to show.


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Daniel Robert David, 64, of Bellevue passed away Monday April 3, 2017 at The Stein Hospice Care Center. He was born March 9, 1953 in Missouri, the son of William F. and Mildred E. (Monnig) David.
Daniel served in the United States Army, was a member of VFW Post 1238, where he also worked as janitor.
He is survived by his wife, Sharon D. (McFaddin), whom he married December 28, 1973 in Bellevue; three sons: Kyle R. David of Bellevue, Corey A. David of Bellevue, and Nathan A. David of Dayton; three daughters, Melissa R. (David) Kreh of Green Springs, Laura E. David of Bellevue, and Emily S. David of Bellevue; grandchildren: Trever Kreh, Dustin Kreh, Crystal Kreh, Logan Pannell, Nevaeh Riley, and Lyvia Riley; brothers: Delmar (Laveda) of Bellevue, Michael (Barbara) of Indiana, John (Paula) of Bellevue, Mark (Wendy) of Bellevue and Theodore of Monroeville; sister, Linda (David) Rudder of Missouri; sister-in-law's, Lynn David of Kentucky and Karen David of Bellevue and many nieces and nephews.
In addition to his parents, he is preceded in death by his brothers: Billy, Delbert and James David.
Friends will be received Thursday, April 6, 2017 from 11:00 am until a funeral service begins at 1:00 pm at Foos and Foos Funeral Service, 151 Yorkshire Place, Bellevue. Burial will follow at York Chapel Cemetery.
Memories and condolences may be shared at www.foosfuneral.com


text: Public bug reported: Affects: kdebase konqueror (Ubuntu) Severity: Normal Priority: (none set) Status: Unconfirmed Description: system:/ and specifically system:/home have lots of issues in KDE 3.5.2. Unfortunately Kubuntu uses system:/home by default instead of /home/user when "Home" is opened through the System-Menu. The System-Menu is the only place that enables access to "Home", so this will be what most users will be using 90% of the time. The issues that system:/home has include but are not limited to these: system:/home shows redundant information in taskbar and current tab http://bugs.kde.org/show_bug.cgi?id=125747 system:/home won't play in amaroK http://bugs.kde.org/show_bug.cgi?id=125746 system:/home kio slave always changes view mode http://bugs.kde.org/show_bug.cgi?id=125744 system:/ kio-slave in KDE 3.5 needs some work http://bugs.kde.org/show_bug.cgi?id=117524 I can only suggest to get rid of system:/home for Kubuntu dapper. This is not the way their filesystem should be presented to the users by default. They will be using non-KDE applications as well, so this has to be fixed. -- kubuntu-dapper: system:/home has lots of issues https://launchpad.net/malone/bugs/39887


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Download QazaSalah apk free for Android smartphone
Posted by meeayee in Personalization | Aug. 24, 2014 | 0 Comments
Apk file size: 0 bytes
Main features include:
1. Set notification time.
2. Add a zikar.
3. View prayers history.
4. View Zikar History.
5. Reminders for Zikar.
Through set notification feature you will be prompted everyday to enter prayers information for that day. The extension of this feature id to view history of prayers and edit the "non offered prayers" only. Additional your can also search prayers by day,month and year all collectively.
Zikar added will be set as reminder on according to the days of week which were selected while adding the zikar. Extension to this feature is to view zikar history and search be "day of week".
You can also set prayers time on calender on main screen by clicking on the default time.
meeayee part of our Personalization and have average installs from 50 to 100. Last Update Aug. 24, 2014. Google play rating is 96.6667. Current verison is None. Actual size 0 bytes.


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Redness + Ear Surgery
When Will the Redness from Ear Otoplasty Go Away?
How much time does it take for the scar to heal? When does th reddish pink go away from the stitches, when do I get my final result of th scar? READ MORE
Redness around stitches(?) after weight lifting (photo)
Had my otoplasty 6 weeks ago and I went to the gym thinking I would be fine. Since yesterday it has been bothering me a little behind one of ears... READ MORE
Question about sutures after otoplasty.
Hello.I had an otoplasty almost a year ago.However the back of the ear and the scar are still red.Recently a couple of sutures surfaced threw my skin... READ MORE
Should I be concerned about my ear pain and redness post otoplasty?
I am currently over a year and a half post Otoplasty surgery, and still experience frequent redness in my ears. I have talked to my surgeon about it,... READ MORE
What are the possible reasons for Otoplasty problems 2 years post op?
It's been 2 years since I underwent my Otoplasty surgery to fix my protruding ears. I've had redness on and off post surgery, but things have never... READ MORE


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Baseball Toaster was unplugged on February 4, 2009.
The New York Post says that Carl Pavano will accept an assingment to the minors, and that Dan Haren is on the Yankees' radar. In the News, Anthony McCarron, has the latest on Godzilla Matsui. Oh, and Steve Lombardi has the scoop on the latest Yankee gear.
By the way, it was no surprise that Marvin Miller was not elected to the Hall of Fame last week. But it was pathetic. And it's been nice to read all of the support Miller has received ever since the snub was announced.
I wouldn't trade Hughes or Kennedy for Haren. I'm willing to give up a premium package for Santana, a genuine blue-chip stud. But Haren's a good pitcher who's had one great year, and I wouldn't trade any of the prize prospects for him.
The same goes for the money as for the player package. Haren may be "cost-controlled," but not nearly as much as Hughes or Kennedy.
If you're going to overpay, overpay for the very best.
That's not a "release plan," it's a "contract." They don't have any freaking choice but to pay him.
Meanwhile, the Yankees DFA'd Bronson Kiheimahanaomauiakeo Sardinha. Not much of a ballplayer. Hall of Fame name.
When adjusting, Babe's OPS+ is WAY higher then Bonds, because the league average was much lower in 1925. Relative to his peers, Babe was WAY better. But if his peers were crappier pitchers and fielders then in 2000 (and all White to boot), Babe's OPS of 1.000 was much easier to get then Bonds' OPS of 1.000 (assuming that Bonds faced better pitching and fielding).
Of course, this doesn't account for ballparks and other factors, but still.... IMHO, comparing leagues in different eras can be misleading because it 'assumes' that the players of each era are equally talented.
I can not find where EQA has any adjustments relative to league or park, but is adjusted by team wins! Team WINS! So if Tony Womack plays on the Yanks, and they have a team .600 WPCT, Tony's EQA is increased by 8.5%. Does this make sense?
Conversely, if Miggy Cabrera's team has a .400 WPCT, his EQA is DECREASED by 8%
So Tony(EQA)= .240, adjusted = .260
Cabrera(EQA)= .350, adjusted = .323
Difference....... .110 .............. = .063
Is this a VALID adjustment what-so-ever????
While I do respect these sabermetric stats, there does appear to be many problems, ESPECIALLY if different stats are taken from MLB vs BR vs BP (or anyone else that has their hands in the stats soup).
MLB REALLY needs to standardize the sabermetric stats, so we at least have a single system where the stats are relative to themselves.
And PARK FACTOR is all screwed up.
Unless there are PHYSICAL changes to a park, shouldn't the PF be static? Why should batting in the Stadium be different in 2006 then in 2000?
IMHO, Park Factor be calculated on some formula involving 1) amount of foul territory, 2) depth of outfield walls, 3) Vision factors (domes, sun, etc) 4) AstroTurf
5)?? (can you think of anything else?)
In 1940, the Stadium had a 96 PF.
In 1945, the Stadium had a 105 PF.
Make any sense to you?
Not be me. Due to the random nature of baseball, more runs just happened to be scored in 1945.
That's a 9% difference. That's a LOT of difference when calculating + stats (or ANY stat that uses PF)
In 1949, the PF was 100. In 2001, the PF was 100.
Make sense? Do you know how much bigger ther park was in 1949?
Anyone think there may have been fewer HRs and more doubles turned into flyouts in 1949?
To me, PF is totally BOGUS in the way it is calcualted. A park has a certain geometry that either hurts or helps (or is 'neutral') hitters. That 'factor' should NOT change unless the geometry is changed.
Of course, my issues are ONLY with Stats that are 'adjusted'. But these are just the Stats we rely on more... aren't they?
PF is based on the runs scored by the home and visiting team that season, so it is a historical stat, not a static metric. Thus, one has to look at PF over the long term, to see how a stadium plays relative to the league in general.
It's like a HR hitter, if a guy slugs 50, 50, 50, 50, 35, and 50 HRs, the HR stat is not screwed up just because one year doesn't seem to "fit." So too, in most seasons Yankee Stadium has played as a pitchers park, but not every season.
As for OPS+, it can only measure performance relative to the league in an empirical manner. Until some type of "White Only" factor can be determined with a high degree of accuracy, it simply will be up to us to debate subjectively whether or not Babe's excellence relative to his crappy all white peers should be discounted more or less than Bonds chemically enhanced performance relative to his athletically superior and racially diverse peers.
Obviously if Lou Gehrig 1932 were transplanted via time warp in 2007, he probably would not be able to compete with even mediocre players. But so what? No one serious assumes that players from different eras were equally good/talented/athletic; they only argue that players in different eras were as good or better (or worse) against their own competition. Moreover, we might even suspect that the great players in any era, if they lived their whole life in the current context--with modern diet and exercise regiments, sports medicine, tougher competition, etc., they would be bigger and stronger, and better. In other words, Gehrig 2007, if he had been born in 1975 or so, would simply be a better than player that Lou Gehrig 1932. Similar, take Bonds 2005 and transport him into the 1930s, take away modern workouts, sports medicine, and, er, enhancements, and he would be a lesser athlete. He probably would still have enough native talent to dominate his competition, but would not be able to compete his 2007 version.
You seem to have a fascination with proving that Bonds is a great player, in fact one of the greatest (if not the greatest) of all time. Does anyone actually dispute this?
There may be any number of reasons a park factor may change over time. One huge factor might be the work of the grounds crew, which we can't measure directly at all. Or perhaps the winds change slightly because someone put up a building across the street, or LaGuardia changed its air traffic patterns. Differences in the overall offensive environment of the game might play better in one park than another.
Instead of trying to figure out what the park effect should be given the physical characteristics, it makes much more sense just to measure what the park effect is.
5 and 7 OK... agreed. Here is what I've found and some conclusions.
PF in OPS+ is basically used to try and neutralize stats between players in the AL or NL ONLY. I confess this is somewhat esoteric, as there is not usually more then a 1 or 2% difference in Average League PF between the 2 leagues. Keep in mind, in computing Team OBP and Team SLG, NL Pitchers numbers are NOT considered.
Since PF is basic a product of runs scored and runs allowed, home and away, if we IGNOR Interleague games, the AVERAGE PF of the ENTIRE NL or the ENTIRE AL should be 1.0000. Correct? While individual stadium PF will vary, NOT counting Interleague, PF does NOT effect a League Average, as it will always be 1.
So... it's only relevance comes into play in InterLeague games only? And... I agree, while run scoring is somewhat random on a day to day basic, over the year and multiple teams and games, it the best method we have.
My question is: What other STATs take into account PF?
If this sort of thing can be done, why doesn't it happen more often to avoid losing a guy you need to stash in miL thru waivers?
Tough crowd.
Please, Cashman, don't sign any mediocre middle relievers. The kids will be fine. And above all, don't sign someone like Mahay just because he happens to pitch with his left arm. A good righty > a mediocre lefty any day.
Pavano...if it's the end of his contract, he doesn't have to clear waivers. He's a free agent, and can sign with any team.
The Yankees are probably assuming that no one else wants to sign Pavano. Probably a good assumption. He had TJ surgery. Realistically, it takes a pitcher 18 months to fully come back from TJ surgery. With Pavano, it could be longer. If he ever comes back.
Pavano is probably thinking the same thing. The Post article said that he needs some place to rehab his arm. Signing a minor league contract would give him that.
Is Jeremy Affeldt any better? Lots of walks. Is there any FA RPs worth getting?
Pavano's not at the end of his contract; it's got one more year. But they released him, which doesn't require any waivers. What it means is that he's a free agent, but the Yankees still have to pay him. He could sign with another team for minimum salary, and the Yankees would have to pay him the rest.
The Dorf
Karstens (the long man)
Kennedy/Mussina (loser of SP audition in ST)
Is that really such a terrible bullpen? Chances are, at least one or two of the kids will stick, and the others can be replaced by Alan Horne or Humberto Sanchez mid-season.
I really hate the Hawkins signing.
I think Horne is slated at a SP next year (Moose gone, maybe Pettitte gone). They might not want him in the BP. Sanchez MIGHT be ready, depending on how he heals from his TJS. Edwar needs another pitch. He's either good or gets creamed. And you forgot Veras?
Hopefully, he'll turn out better than the last Hawkins the Yankees signed--Andy.
He ended up having season-ending shoulder surgery. Which may explain why he never hit that well, for the Yankees or the Braves.
As far as MLB standardizing the "SABR stats" MLB didn't develop them, so why should they standardize their definitions. I'm not aware of any department within MLB that is responsible for standardizing statistical definitions, and if there were one, they'd probably screw everything up.
But who's next? The Yanks still have to add A-Rod and Mo to the roster.
As for OPS+, I don't share your skepticism (beyond the park adjustment component). With era and league adjustments, all you are trying to do is compare a player to his peers. So, while Babe Ruth's generation might not have had as many athletes, it's also true that the players didn't have the same amenities to maximize their talent (e.g., weight training, not having to have off season jobs, charter air travel, etc.). Also, while the Babe faced a limited talent pool, it's also true that there was less competition from other sports as well as fewer jobs available. Because the number of variables in each era is so large, I think it's much better to compare players in different eras based on how they performed relative to their peers.
There's no proof yet that Dorf, Edwar, etc. are ready for the major leagues. The best relief arms (Melancon, Cox, Sanchez) might not even pitch this year. Signing Hawkins is just covering your ass.
Any longer than 1 year and it'd be bad. But it's not.
That's pretty sweet for way below market value.
League average last year was a 4.47 ERA.
If it was a long-term deal, I'd agree that Hawkins should be passed over, but I think he will be useful. I like him better than Viz anyway, but in a perfect world, the Yankees would shed Farns and go with Viz and Hawkins as the veteran component in a bullpen of young set-up men.
25 Matt Guerrier 72.040 A
26 C.J. Wilson 70.732 B
27 Luis Vizcaino 70.201 B
But the Yankees have too many veteran players who are approaching their DH days. If they can get a good return on one of them, I can't get too upset.
I'm also not sure Matsui would agree to go anywhere. He's been equivocal in his public statements, but that might just be Japanese reticence. He's proved he can be tough when it comes down to business.
I'd move him in the right deal. But am I the only one that wouldn't settle for a relief pitcher not named Street?
I'd move him in the right deal. But am I the only one that wouldn't settle for a relief pitcher not named Street?
"GreenBeret7 - go back to rooting for the sox. How dare you question Jeter. Jeter was playing on one knee for most of the season and playoffs last year.
Oh, you are so knowledgeable sitting in front of your computer, stuffing your face with poptarts, and typing with your pudgy fingers venom against the greatest player of our lifetime. Knock it off."
The OPS+ formula for a Players is:
OPS+ = 100 * (OBP/lgOBP(adjusted) + SLG/lgSLG(adjusted) - 1)
Does this mean that Ortiz's OPS+ is adjusted by the exact same factors as ARod's (or for that matter, any Player in the AL)?
If Ortiz has a higher OPS because Fenway is generous, how does that (OPS+) formula equal one players OPS to anothers?
Am I missing something?
In the OPS+ formula above, if in the SAME Year, ARod and Ortiz have the same OBP and same SLG, don't they both have the same OPS+?
Year, INN, ERA+, WHIP
2002, 80, 210, .097
2003, 77, 243, 1.09
2004, 82, 167, 1.05
2005, 56, 113, 1.46
2006, 60, 102, 1.46
2007, 65, 140, 1.23
His age and creeping WHIP are worrisome, but overall his performance has ben pretty solid for a reliever. Maybe they squeeze one more year of 1.2 WHIP and 120 or 130 ERA+--that's not so bad.
So player B looks MUCH better then Player A, but his actual 'production' is NOT that much better. So the SLG part of OPS 'penalizes' a player for getting BBs.
The formula for OPS might be better if it was: OBP + SLG + (0.3(BB/AB+BB))
So Player A would be:
Not as Good as (A) OPS=1.000, but better then 0.875
So Hafners OPS+ is 6% higher while Ortiz's PF is almost 16% higher. However, half of a players OPS (AWAY Games) should NOT be adjusted, only the Half at Home. So that 16% becomes %8%... so that seems pretty close.
(from the link you gave me)
Using the formula:
PRO+ = 100 * ( OBP/lgOBP + SLG/lgSLG - 1)/BPF
would make more sense as the players PF is directly in the equation... although Hafners OPS+ should be closer to 15% higher then Ortiz's. However, half of a players OPS (AWAY Games) should NOT be adjusted, only the Half at Home.
"Using these adjusted values compute what the league average player would have hit lgOBP*, lgSLG* in a park."
Take OPS+ = 100 * (OBP/lgOBP + SLG/lgSLG - 1)
ahhhhhh... I'm not sure but I THINK what he is doing is NOT using a players ACTUAL OBP but:
1) Calculating his Runs Created
2) Multiplying RC by (players) PF
3) BACKcalculating H, BB, HBP, TB needed to create the Adjusted RC.
4) Using these backcalculated number to create and adjusted OBP.
That's what I missed. I didn't get that the OBP and SLG numbers is his formula were not Actual, but adusted.
HOWEVER, all these adjustment factors, which we are applying to OBP and SLG are either RUNS (traditional method) or Runs Created (hibred method).
Does this mean we ASSUME that RUNS (or Runs Created) is directly relational to OBP and SLG? (I think not)
In the formula: = 100 * (OBP(adj)/lgOBP + SLG(slg)/lgSLG - 1)
Rather then adjusting OBP and SLG then way he does, how about using
Player OBP/((Park OBP + LgAvgOBP)/2) / LgAvg OBP) and
Player SLG/((Park SLG + LgAvgSLG)/2) / LgAvg SLG)
I think between all minorities, as well as international players, the pool of possible players is many times greater then in Ruth's day. Look at how many great non-white players we have now. How about modern vs 30's scouting practices?
My guess is you are correct that raw talents like Gehrig, Ruth, Cobb, Speaker, Hornsby, Wagner and the best players of the past could compete today. But what about the average and poorer players? There were the pitchers pitching against these great guys, and fielding against them.
With all with know about the science of pitching today, could pitchers of the 30's really be as good as todays pitchers? Look at the glove the 'all White' players used in the 30's. Do you really believe defense was as good back then?
They had no MRIs or other diagnostic equiptment. How many guys played injured? We will never know, but I can't believe the overall level of play in the 30's was as good as it is today.
I know that the color line made a big difference. I believe the NFL and NBA alone make up for that difference. Add about 150 other sports (skateboarding is a big money deal, as is beach volleyball, surfing, skiing (etc), Jai Alai, and so forth. Add to that the great number of kids who just aren't into sports at all (a much higher percentage than in the 1880-1940 era.)
I think another factor is little league-instead of a bunch of kids getting 20 or more ABs playing other kids, nowadays you don't even have any place to play unless your on a LL (or similar) team, and there's no way you're getting half that many ABs. (not to mention the fun having been sucked right out of it by idiot parents.)
It's not really fair to take Babe Ruth of 1920 and think about how he'd fair in the modern game. You have to assume that he'd have adapted to the modern times. Similarly, if we transport Bonds back in time (assuming he was allowed to play) we'd have to wonder how healthy he would have stayed without his space age workouts (enhanced or not), thin handle/light weight bats, video technology and comfortable cross country travel.
I'm quite fond of Hideki, despite the fact that he drives me to distraction with his dribblers to second, and yet I'm really not that keen on keeping him. If he stays, great. If he goes, so long and thanks for all the fish.
He's an awfully solid player, though, and certainly someone who could help the team in a reduced role, so he better not be given away.
Comment status: comments have been closed. Baseball Toaster is now out of business.


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Lyrics Depot is your source of lyrics to Little Girl Cried by Conway Twitty. Please check back for more Conway Twitty lyrics.
Little Girl Cried Lyrics
Artist: Conway Twitty
Album: Fifteen Years Ago
And a little cried cause a little boy lied
The vows that he made he broke and betrayed
And her little heart broke cause the words that he spoke
Were just tenrder lies and a little girld cried
She was too young to know that he'd soon hurt her so
So she gave him her heart never dreamed they would part
Now it's over and done he's had all his fun
He just told her goodbye and a little girl cried
[ guitar - piano ]
She was too young to know...
Conway Twitty Lyrics
Conway Twitty Fifteen Years Ago Lyrics
More Conway Twitty Music Lyrics:
Conway Twitty - Crazy In Love Lyrics
Conway Twitty - Get Some Loving Done Lyrics
Conway Twitty - God Bless America Again Lyrics
Conway Twitty - I Changed My Mind Lyrics
Conway Twitty - Let Me Be The Judge Lyrics
Conway Twitty - Love Is The Foundation Lyrics
Conway Twitty - Maybelline Lyrics
Conway Twitty - My Love For You Is Stronger (than The Weakness In Me) Lyrics


text:
Camera and Video
Ask a Camera and Video Question, Get an Answer ASAP!
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If any page, with letters on it, is too small to read, here's a trick:
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That should expand, or 'Magnify' your screen... hopefully to the point where it becomes fully readable.
Not Ctrl-Alt, please.
Just (in summary)
Ctrl - Shift - + (repeatedly)


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Thank you to Grant Glover for creating WikiTree profile Young-10132 through the import of Benjamin Young.ged on Dec 12, 2013. Click to the Changes page for the details of edits by Grant and others.
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Some pilots will make an emergency out of a bad brake check. Others, upon losing a wing, will ask for a lower altitude.
Category Archives: Flying
Emily goes aerobatic in the Super Chipmunk
Emily got a ride with Mark Meredith in his amazing Super Chipmunk. She even said yes to some gentle aerobatics.
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Aviation Quote of the Day: Fuel
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Though I Fly Through the Valley of Death I Shall Fear No Evil For I Am 80,000 Feet and Climbing. – Sign over the entrance to the SR-71 operating location on Kadena.
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Aviation Quote of the Day: Planning
Getting down with the other-way up
I'm trying to get more comfortable inverted. I'm so new to aerobatics that just a minute of inverted flight, straight-n-level with the gentlest of turns, is challenging. To maintain coordinated flight, the aileron and rudder inputs are opposite each other. Flying normal-side-up, pilots instinctively use left aileron with left rudder to make a coordinated left turn. All that goes out the window (canopy?) inverted. Awesome.
Eventually, being comfortable with negative-G will be an advantage. I'm not very good at it yet. (I already know I need to get more stick-forward authority from my elevator trim system, so I don't have to push so hard.)
Aviation Quote of the Day: Confusion
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Flying is the second greatest thrill known to man…landing is the first!
Quote of the day – Experience
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|January 7, 2017, 03:31 PM
Senior Member
Join Date: March 9, 2016
Posts: 318
How do you guys avoid tendinitis?
Well, woke up this morning with my right elbow hurting, this is after decapping and sizing, in two different steps, 1000 40 and 1000 223. So essentially 4000 pieces
I just picked up one of those neoprene elbow braces and that helps a ton with the pain, but how can reorganize to eliminate whatever naughty angle or movement in doing? Right now my bench is standing height, I believe the top is around 42". And I use a Lee classic cast turret, usually without the auto index, so single stage basically
Last edited by nhyrum; January 7, 2017 at 04:15 PM.
|January 7, 2017, 04:23 PM
Senior Member
Join Date: December 3, 2012
Posts: 494
Never heard of it from reloading. However, I occasionally get it when I do a hard arm day in the gym doing curls. The neoprene cuff helps, but the key is to get the blood moving in the elbow via a warm up prior to the activity causing the pain.
Even if its only reloading, doing some warm up exercises that get blood into the elbow area will make a difference. Get some light hand weights, bring your forearms to a 90 degree angle and rotate at the wrist inward and outward. This will get the blood flowing to your elbow.
|January 7, 2017, 04:41 PM
Senior Member
Join Date: January 2, 2017
Posts: 122
I play competitive tennis and as such have suffered from tendinitis a few times. The sleeve is a great idea and I highly recommend Penetrex cream (search Amazon for it). Great stuff.
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|January 7, 2017, 05:02 PM
Senior Member
Join Date: February 27, 2015
Posts: 1,221
Poor posture, odd angles, yanking.
Take an anti-inflammatory day of, day after.
Raising my press helped a bunch.
Information found on the 'Internet' is worth EXACTLY what you paid for it...
Everyone on the internet is an 'Expert'.
|January 7, 2017, 05:08 PM
Senior Member
Join Date: April 16, 2011
Location: Georgia
Posts: 1,485
Do the same as I do for riding my bicycle. I put Aspercreme or generic equivalent on before and after my ride, regardless of miles or how hard I ride...just do it every time...it helps the tendons and ligaments around my 56yr old knees. It will do the same for your elbow.
|January 7, 2017, 05:10 PM
Senior Member
Join Date: March 9, 2016
Posts: 318
What is the proper posture for reloading? I've learned how to type properly to avoid carpal tunnel, but never really hear about the correct posture to avoid tendinitis
|January 7, 2017, 05:55 PM
Junior Member
Join Date: December 26, 2016
Posts: 3
May look at some of the aftermarket handles for your press. I got one for my LNL at it made resizing much easier!!!
|January 7, 2017, 08:43 PM
Senior Member
Join Date: February 19, 2013
Location: Atlanta, Ga
Posts: 306
Here is your answer... https://inlinefabrication.com/
I had similar issues because my body wasn't properly aligned with the press, sitting or standing. I have a Lee 3-hole turret press and have never had a single minute of discomfort since I purchased my In-Line Fabrication riser. It is by far the best investment I made as far as my loading equipment is concerned.
Good luck. Feel better.
non ministrari sed ministrare
|January 7, 2017, 09:35 PM
Senior Member
Join Date: February 27, 2015
Posts: 1,221
Figure out how you are doing things now, cause that ain't working.
You have to know where to start...
I have been shot twice, blown up twice, three aircraft crashes in the military, and broke a bunch of stuff racing, working, etc.
Believe me when I say, 'SUPPORTING, Comfortable Chair with feet flat on the floor',
And the press lifted up where you can see/reach the shell plate without stopping over...
The second thing is don't confuse bruised muscles/tendons from doing something new with outright tendinitis.
Sore, slightly inflamed tendons let you know about it, outright fully swollen tendons won't let you sleep or move your body.
So called 'Ergo' handles don't work for me very well or very often...
They cause 'Roller Wrist' or 'Limp Wrist' issues when sizing to start with,
They also are ALWAYS cut to to the wrong angle so follow through has my hand/wrist at an odd angle.
I like a 'Ball' handle, something I can put significant pressure on it at the TOP of the stroke, and the BOTTOM of the stroke,
Ergos are made to make the CENTER of the stroke more comfortable, which is a ONE finger operation for me since the case is free of dies.
With a ball I can adjust my position in the chair, adjust my shoulder to the press, etc and still apply pressure where it counts.
I don't use a 'Swivel' or 'Roller' chair.
You won't notice it, but you are expending MUCH more movement fighting the movement of the chair when you are working.
Nothing like fighting stiff brass, fighting the chair AND the press too low...
Leaning over to push down to size is direct pressure on shoulder/elbow with your body weight...
I like the Up stroke about an inch below my shoulder where I'm reaching straight out, without reaching up.
Keeps me from pranging on a bad rotator cuff and torquing on bad neck disks.
Information found on the 'Internet' is worth EXACTLY what you paid for it...
Everyone on the internet is an 'Expert'.
|January 7, 2017, 09:40 PM
Senior Member
Join Date: December 6, 2014
Posts: 3,540
Don't do 4000 repetitive motions at one time............
FITASC: Fédération Internationale de Tir aux Armes Sportives de Chasse. http://www.fitasc.com/uk/home/view
|January 7, 2017, 11:25 PM
Senior Member
Join Date: August 25, 2008
Location: 1B ID
Posts: 10,089
That ^^^^
"Such is the strange way that man works -- first he virtually destroys a species and then does everything in his power to restore it."
|January 8, 2017, 01:00 AM
Senior Member
Join Date: December 27, 2008
Posts: 484
In-line Fab. is the only way to go.
I especially like their roller handles.
Another tip that might help is concerning case lube.
.223 sizing is not noticeable on my 550 with proper lube and, while I do
not load for a .40, I lightly lube my 9mm and larger handgun brass
when carbide sizing.
Eliminates almost all the effort.
|January 8, 2017, 08:14 AM
Senior Member
Join Date: August 13, 2001
Location: central IL
Posts: 679
There are some simple exercises to cure tendonitis. Painkillers are your enemy.
|January 8, 2017, 08:19 AM
Senior Member
Join Date: November 21, 2013
Posts: 784
OP, you need to SLOW DOWN !! I was into the same bahavior when I first bought my LEE Classic turret. I was attempting to bang out 300 rounds of ammo weekly. Thousands of arm repititions weekly finally took it's toll and I too got tendinitis in my right elbow joint. I'm better now and the tendinitis has minimised over the past year. Here's my tips :
2) If possible learn to load ambidextrous (allows you to use both arms, giving rest to stressed joints)
3) pay critical attention to your specific loading technique ergonomics. Access every step and try to minimise joint movement. Have your loose bullets as close to your press as possible, same with your final loaded bullet.
4) if possible minimise the ram stroke. I learned to spin my LEE Classic Turret die head by hand instead of cycling the ram to move the toolhead to the next station. This was a substantial step in lessening my arm repititions.
a) I was able to "choke up" on the length of my LEE CT's ram handle. You can loosen the clamping bolt and slide the handle so the handle is actually shorter in lenght which equals less of an arc stroke needed to cycle the press turret.
5) detailed prep of the primer pockets on crimped brass. I attribute most of my tendinitis not from resizing, but trying to seat stubborn primers. It requires a lot of unncecssary force to seat tight primers. I learned to do a nice forgiving chamfer and a quick ream using my Lyman case prep center. This keeps the primer insertion easy.
6) use Imperial Sizing Wax. It's awesome stuff and makes easier work of sizing casings.
7) Do what I did, get a Dillon 650 ! LOL
"To be old an wise you must have been young and stupid"
|January 8, 2017, 12:47 PM
Senior Member
Join Date: September 28, 2008
Posts: 10,447
Reloading machines seem purposely designed for aggravating joints.
Youtube has plenty of exercises that can help.
Until then, use the elastic bands, they do work.
But they don't cure anything.
The exercises will strengthen the tendons and muscles around the joints.
Worked for me.
Walt Kelly, alias Pogo, sez:
"Don't take life so serious, son, it ain't nohow permanent."
|January 8, 2017, 01:37 PM
Senior Member
Join Date: February 13, 2002
Location: Canada
Posts: 8,218
Kind of suspect it may have been present before you started. However, like FITASC says, not doing 4,000 cases at one time is your best bet. Most of us don't do that much "work" in a week.
JeepHammer, Mother Nature seems to be trying to tell you something. Or you PO'd her good. snicker.
Spelling and grammar count!
|January 8, 2017, 01:54 PM
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Join Date: December 28, 2006
Posts: 3,393
|January 8, 2017, 05:17 PM
Senior Member
Join Date: March 9, 2016
Posts: 318
That's the kind of info I'm looking for!
By the Up stroke, do you mean with the ram all the way at the top, and the handle at the bottom?
Maybe this will be some leverage for a Dillon 650. And a reason to not buy thousands of range brass and expect to get loaded ammo in a week.
I do have imperial, but that in reserved for my br ammo. The rest I use home brew lanolin Lube
Edit: was on a short road trip and just got back and hit the press. I think a riser is needed. With the ram at the top of its stroke I have to lean to the side to push all the way to the top of the stroke. Doing that, even with the neoprene brace hurts the elbow.
Last edited by nhyrum; January 8, 2017 at 07:47 PM.
|January 8, 2017, 07:45 PM
Senior Member
Join Date: September 12, 2015
Location: Issaquah WA. Its a dry rain.
Posts: 1,167
Stop doing thousands of pulls in a sitting!
Take the time to do a few hundred a day rather than thousands a day. Spread it out over time, its a hobby man, not dire straights.
To crimp, or not to crimp, that is the question.
Just shoot the damn thing.
|January 8, 2017, 08:29 PM
Senior Member
Join Date: March 9, 2016
Posts: 318
Oh wait... I think I know what the culprit is... The hundred or so rifle rounds I disassembled with my kinetic puller... Some took a good 10 whacks...
|January 8, 2017, 08:56 PM
Senior Member
Join Date: August 2, 2014
Location: Virginia
Posts: 481
I never do more than 500-600 press actuations at a session, often more like 300-400. With my SDB, that yields an equal number of rounds of loaded ammo, with the Rockchucker, it yields one step in the process for that number of cases.
I have a tall in-line fabrication press stand and work standing up. I find it gives me the most leverage.
Loading 1000 rounds of pistol on the SDB takes me three sessions, each a little over an hour. For .223, it's more like 6 hours spread over two weeks.
|January 8, 2017, 09:25 PM
Senior Member
Join Date: November 21, 2013
Posts: 784
I fabbed a 14" riser to get both my Dillon 650 and my Rock Chucker to position the handle about even with my shoulder while standing. I also have a nice thick foam mat on my floor to allow me to stand for longer periods of time while I reload.
"To be old an wise you must have been young and stupid"
|January 8, 2017, 11:16 PM
Senior Member
Join Date: March 9, 2016
Posts: 318
Yeah I think a riser is indeed needed.
I just love reloading that it's hard for me to not when I have the ammo to reload
|January 8, 2017, 11:54 PM
Senior Member
Join Date: February 23, 2005
Posts: 12,870
I find sitting - and reloading - at " a bar stool height " stool is way easier on my feet, knees and back...than standing.
I have also put the "roller handle" on my press vs the ball handle..../ and my bench height has adjustable steel legs to raise or lower the height of my bench over a 6" range ....and if I needed more I could put adjustable casters on the legs I suppose.
Not over gripping the press handle helps / i have arthritis in hands and wrists...and some orthopedic repairs in elbows and shoulder....so I think it's smart to limit a session to about 30 - 45 min ...and settle for 7 or 8 boxes ....vs sitting at bench to do 30 boxes at once...
|January 9, 2017, 10:46 AM
Senior Member
Join Date: November 21, 2013
Posts: 784
Over the years progressing from a single stage , up to a turret , and most recently a Dillon 650 ive come to realize that handloading needs to be a compramise of speed and minimal muscle strain. Handloading wont be of use to me if my joints are trashed 10 years from now. Im 51 and i want to enjoy retirement shooting and reloading pain free. As soon as i feel some joint discomfort i stop for the night. Tendinitis is a b!tch to get rid of it. Im ususlly good for about +/- 40 joint repititions every other night depending on the effort required by the task needed.
"To be old an wise you must have been young and stupid"
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Forum OpenACS Q&A: Re: carnage blender is live on aolserver 4 beta5
10: Re: carnage blender is live on aolserver 4 beta5 (response to 1)
Posted by Andrew Piskorski on 05/08/03 08:32 PM
Wait a minute, Jonathan, would it be sufficient to simply lock the mutex before trying to destroy it? Or am I missing something here?
If the problem exists in 3.3+ad13, I at least have never encountered it there, despite fairly heavy use of ns_mutex from multiple threads. But perhaps I coincidentally happen to not be triggering the bug.


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June 26, 2007 - Industry News
Con-way Inc. has launched the Con-way Leadership Academy - a corporate initiative designed to provide education and training across a wide spectrum of functional and leadership roles, spanning operations, sales and management.
The Truckload Carriers Association's Inaugural Leadership Summit, "Leading for Change: Effecting Cultural Transformation," will be held July 17-18 at the Four Points by Sheraton Chicago O'Hare Airport
Tags: Events
GE Capital Solutions' transportation finance unit has launched a full range of financial solutions, from leases and loans to wholesale floor plan financing, to the medium-duty truck sector (Classes 4-7) specifically targeting
Ryder System Inc., a global leader in transportation and supply chain management solutions, has announced its top carrier selections for the 2006 Ryder Carrier Quality Award. This award recognizes excellence through a variety of metrics,
Advantage PressurePro is now supplying Flying J locations with its tire pressure monitoring systems through the Flying J e-Store, according to PressurePro CEO and President Phillip G. Zaroor.
In addition to an array of technical sessions, the Technology & Maintenance Council's 2007 Fall Meeting, scheduled Sept. 24-27 in Nashville, Tenn., will include an advanced technology display and a technician training fair held in conjunctio
June 25, 2007 - Industry News
A convoy of Los Angeles and Long Beach port drivers will jam the Harbor Freeway (110) with tractor-trailers during the morning rush hour Wednesday, in conjunction with a scheduled meeting of port stakeholders in Long Beach,
Peterbilt Motors Co. recently announced the introduction of the new Model 325, its first vehicle dedicated to the specific needs of the Class 5 market. The Model 325 is tailor-made for a range of Class 5 application
A death and injury lawsuit has prompted a U.S. tire importer and distributor to ask the National Highway Traffic Safety Administration for help in recalling nearly half a million Chinese-made light truck tires
The Parts Marketing Program for Mack Trucks Inc. and Volvo Trucks has been recognized for marketing excellence by the Transportation Marketing & Communications Association's (TMCA) 2007 National Compass Awards program
Paccar Leasing Co. (PacLease) continues to steadily expand its franchise network in North America with the addition of 10 locations in the United States and two new locations in Canada.
"These locations are representative
Boyd Bros. Transportation Inc. opened its Cincinnati, Ohio, facility late last year to support operations in that city and surrounding area. Since then, drivers have had access to many services they enjoy at th
SEKO, a global provider of freight forwarding and logistics solutions, recently expanded its operations into the Republic of Turkey. The new SEKO Turkey station, headquartered in Istanbul, offers airfreight, sea freight
June 22, 2007 - Industry News
Kenworth Truck Co. has expanded its "green" message with the addition of 30 new stops on the Kenworth Clean Power Technology Tour, which is traveling to Kenworth dealers throughout America this year.
Hino Trucks has increased its U.S. dealer network to 150 nationwide, and with plans to add up to 30 additional dealers during the 2007 fiscal year. Since the inception of its conventional truck model in 2004, Hino Truck
Hino Trucks has increased its U.S. dealer network to 150 nationwide, and with plans to add up to 30 additional dealers during the 2007 fiscal year.
Since the inception of its conventional truck model in 2004, Hino Truck
Hormel Foods Corp. has selected Decker Truck Line Inc. as one of 51 suppliers to receive their "Spirit of Excellence" award for providing quality service and products
Three leading aftermarket chief information officers (CIOs) will be featured on the Tuesday, July 17, agenda during the 2007 Aftermarket eForum, which runs from July 16-18 at the Hyatt Regency O'Hare in Chicago
NationaLease has a new web site that enables businesses to rent trucks through the company's vast network of members. NationaLease provides a full range of commercial truck rentals from which to choose
Haldex Brake Products Monterrey, Mexico, has been awarded the ISO/TS 16949:2002 certification as a manufacturer of air brake actuators including product design, purchasing, sales and customer service.
Everco Heavy Duty, the Texas-based manufacturer and supplier of HVAC components for the heavy-duty market, is actively promoting its climate control products
Westpac Heavy Duty/C. W. Carter Co. has launched its new web site, featuring links to more than 1,000 manufactures sites as well as one of the most complete cross reference listing in the trucking industry.
The National Private Truck Council (NPTC) is again teaming with J. J. Keller & Associates to present the second in a series of free webcasts related to Performance Management Technology on Wednesday, June 27th, from 1 - 2:30 p.m. (Central).
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American Trucking Associations Chairman Ray Kuntz testified before the House Veteran's Affairs Subcommittee late last week on economic opportunity in support of expanded educational benefits for veterans
Shell Lubricants has announced the launch its second annual Shell Technology Tour. The 2007 tour will visit 10 cities across the U.S. and is designed to update fleet customers about the latest industry changes including:
We offer e-newsletters that deliver targeted news and information for the entire fleet industry.
Scott Sutarik from Geotab will answer your questions and challenges
Steve Carlson from Xantrex will answer your questions and challenges
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Get your Perfect Engagement Ring by dropping hints!
Jaycee De Leon
Perhaps being married to a Jeweller was easy for me to discuss what my ideal Engagement Ring was (although he would still say I was a pain in the you know what). But for some couples the talks on marriage is always a bit daunting and can sometimes scare him into thinking if he is ready or not, but whatever you do DO NOT PRESSURE HIM.
Yes I get it! all your girlfriends have that sparkly finger and eventually getting married, while your still waiting to be asked? I was once that person waiting... and waiting.... and waiting..... haha! I see this happening all the time but one thing I have learnt while being in the Jewellery World is when a man is ready to pop that question he will go out his way in making sure the waiting was worth it.
Take advantage of Social Media without trying to get him to go 'Ring Window Shopping' with you and looking desperate that you want him to take it to the next step. Come on ladies we've all been there and for those who are still wondering when or if he will pop the question in the mean time drop some hints.
1. PIN IT! The Power of Pinterest! I am a huge fan of this clever virtual mood board! If you haven't already signed up ... then do it ....... now! Link it with your Facebook and start pinning all the gorgeous engagement rings you would 'one day ' like to own! You never know your future fiancé may just stubble upon your dream ring and with your help he will get it right! Pinterest is perfect for everything such as wedding planning / decorating ideas / fashion ideas.... just everything!
2. I GET BY WITH A LITTLE HELP FROM MY FRIENDS Yes! tell your girlfriend what you want don't be shy! go ring shopping together why not!? If your future fiancé is looking to share his plans in proposing it would be your best friend he contacts to see what ring you would like. Unless he know 100% what you are after then you are one lucky chick, not all men are clued up when it comes to picking the right ring.
3. THE OLD FASHIONED WAY If your anything like me you would just tell him and show him photos. Tell him what you want theres nothing wrong with that - Platinum yes! Grey Pear Shaped Diamond please with an extra White Pear Shape next to it and if possible it would look really pretty with some smaller diamonds around it and down the shoulders?
Go on Google Images while you're staying in on a Saturday night with a takeaway 'Honey this ring is gorgeous! ' Tell him what you don't like about certain rings and why you prefer a certain a style. Cause when they decide to put that ring on your finger he will be on his own without you telling him.
There is no harm is telling you're future fiancé what you want it will make his life easier and you wont moan that he got it wrong its a win win situation.
4. SHARE/LIKE/TAG ON FACEBOOK ah the famous Facebook! Tag him in photos of engagement rings, only you know your relationship whether its at the 'comfortable' stage for you to tag away lol don't be tagging him after the 1st month of dating and don't go overboard either you might justscare the thought out his head! Perhaps get your BFF to tag your other half in a ring you like?
5. ASK HIM and I don't mean ask him to marry you. Get him to show you photos of what he thinks you would wear or what he would like to see you have. This can be fun and not as daunting as you make it.
Or LEAVE HIM TO IT theres nothing more attractive than a man who just gets on with it and takes charge without us ladies interfering! either way you wont be disappointed.
CAUTION...... Please do not use all 5 hints on the poor guy :)