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*Offer, if any, is valid for new buyers who purchase a home in a participating community and deposit between 9/9/17 and 10/1/17, sign an agreement of sale, and close on the home. Offers, incentives, and seller contributions, if any, vary by community and are subject to certain terms, conditions, and restrictions, including but not limited to the availability of home sites. Toll Brothers reserves the right to change or withdraw any offer at any time. Not valid with any other offer. Photos are images only and should not be relied upon to confirm applicable features. See sales representative for details. This is not an offering where prohibited by law. Listing Broker: Toll Brothers Real Estate, Inc. Not all customization requests can be honored.


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The Florida Panthers continued their remarkable run of form with an 11th-straight win on Thursday, as they overcame the Ottawa Senators 3-2.
Aleksander Barkov scored an important third-period goal, putting the Panthers 3-1 up and out of sight of the Senators, with Milan Michalek's sixth goal of the NHL season proving merely a consolation.
Reilly Smith and Vincent Trocheck both scored their 12th goals of the campaign, before Barkov's third-period goal - which also proved his 12th of the season.
The Philadelphia Flyers won just their second game in five with a tight 4-3 victory over the Minnesota Wild.
The Flyers were looking good midway through the second period when quick goals from Michael Del Zotto and Ryan White put the visitors 3-1 up, but a late equaliser from Minnesota's Zach Parise made it 3-3.
Del Zotto scored his second of the game in overtime to seal the win for the Flyers.
The Washington Capitals stayed clear of the Panthers atop the Eastern Conference with a dominant 4-1 effort against the New York Islanders, while the Dallas Stars overcame the Winnipeg Jets with a 2-1 shoot-out win.
The Toronto Maple Leafs saw their three-match winning streak ended with a 2-1 loss against the Los Angeles Kings, while the Detroit Red Wings defeated the San Jose Sharks 2-1 courtesy of a Justin Abdelkader goal in the third period.


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A blog by Peter Berti
"We all want progress, but if you're on the wrong road, progress means doing an about-turn and walking back to the right road; in that case, the man who turns back soonest is the most progressive."
- C. S. Lewis
Recent Blog Entries: Peter Berti
We ran an MNCH household survey for our project in Nepal. The last interview was finished on Saturday, and the data were analyzed and shared with partners yesterday – about 48 hours after the final person was interviewed.
Figuring out how old a child is harder than you might think, and treatment of age data requires special attention.
Can chickens make a difference to the diet of the rural poor? I think so, and so does Bill Gates, but a few others disagree with him.
Prime Minister Trudeau made an announcement this morning about continued funding for the Global Fund.
The story of an unsuccessful proposal. Shortlisted, but no cigar.
The "Responsible Consumer" campaign in Ecuador is working to improve the national food system, and we are working to understand the campaign and make it more effective.
We estimate that through the Pakur project 159 neonatal deaths and 7 maternal deaths were averted. If the program in Pakur was scaled up to reach all of India, each year there would be 770,000 neonatal deaths and 32,000 maternal deaths averted.
There are at least four types of food fortification: (1) Industrial fortification of staple foods; (2) Household level fortification; (3) Fortification of processed foods; and (4) Biofortification. The first two I support; the latter two I do not support.
I share some reflections on focusing on the positive.
I attended the The Muskoka Initiative Consortium Results Symposium in Toronto on 23 and 24 June 2015, where I had the opportunity to talk briefly about some of the challenges faced in evaluating health interventions, particularly with regards to data management and analysis.


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Good news for all good music friends. Our next massive release Josh Jayden Survive is out now. Grab your copy in all download stores worldwide.read more >>
Musicheads Rec and Eriq Johnson present Deep House Vol.1 set with over 1,2GB of 24Bit "ready to go" wave samples and loops. This pack contains 120BPM loops in different categories: Arpeggio, Bass, EPiano, Melody, Percussion, Synth, Vocal and different variations of Drum Loops. In this set you will also find a nice collection of drum one shot samples: Kicks, Crashes, HHats, Percussion, Snares and Claps. 60 Synth Loops …read more >>
We are happy to present our sample pack Eriq Johnson - Deep House Essentials. This pack includes 1,1GB of WAV 24-Bit @ 44.1kHz audio material. All samples and loops were recorded in a professional analog studio, have 120bpm and are organized in a detailed folder structure. The sample pack contains deep house loops in categories: Arpeggio Loops, Bass Loops, EPiano Loops, Percussion Loops, Synth Loops, Vocal Loops and different var …read more >>
We are very proud to present the new comedy movie from New Channel with such stars as Serega, Alan Badoev, Vasili Virastjuk ans Musicheads sounds on board. Such songs as Champagne Morning Your Day, Fly High, My Home, Miracle are included in official soundtrack of the movie. You can buy the songs in all download stores worldwide.read more >>
Datdude - Night Still Young is out now and available in all download stores worldwide!!! Grab your copy! Tracklisting: Freaky Sexy Ladies, Falling In Love (prod Eriq Johnson), Built 4 Us (Matt Bueller), Night Still Young (Remix Xclusive), Night Still Young, Take You Home, Take You Home ft. Danyka (mix francais)read more >>


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Identifying Fulfillment Laura Woermke We like to think that we each have a "story" to tell, a linear progression through life. But what if there is no story? Or, what if our story is simply an invention, not a reflection of 'truth', but an arbitrary collection of shifting memories and items? What if the past is a dream and the future never arrives? How then do we know who we are? Through my work I will investigate these questions, pouring over them, searching for meaning, with some foundation in the elements of what brings meaning and fulfillment to our lives. A great deal of my art springs from the documentation of external items that bring gratification to oneself. 'Story' implies narrative structure. Using the human form I wish to investigate the many situations of fulfillment. For the Female this can sexual, body manipulation, marriage, and as simple as a good bra. We need stories, and to tell stories, because we need them to define ourselves, to serve as a lens through which we understand, conceive and create our lives. Without them we would simply disappear.
Biography: Curriculum Vitae Laura Woermke b.f.a. Born: London, Ontario. May 11 1968. Education: Honour - Bachelor of Fine Arts, University of Windsor. 1990-1993 Diploma in Visual Arts, Fanshawe College of Arts and Technology 1987-1990 Solo Exhibitions 2008 - So what if you Can See, Gallery Lambton, Sarnia Ontario 2005 - Woermke @ the Beanery, St. Thomas, Ontario. 2004 - Infliction, Rainbow Cinemas, Market Square, Toronto, Ontario. 2004 - Catharsis, St. Thomas - Elgin Public Art Center, St. Thomas, Ontario. 2002 - Green Art, One London Place, London, Ontario. 2001 - A Personal Journey, St. Thomas - Elgin Public Art Center, St. Thomas, Ontario. 2 Person Exhibitions 2007- Painted and Tainted, Gallery Lambton, Sarnia. Ontario 1995 - 99 King, London, Ontario. 1992 - Bare Breasts and Bowls, Common Ground Gallery, Windsor, Ontario. Juried Group Exhibitions 2006-2003 - Paint the Huron Shores, Grand Bend, Ontario. 2006-2003 - Look, Gallery Lambton, Sarnia, Ontario. 2001 - Applications, Copps Gallery, London, Ontario. Group Exhibitions 2005- Rainbow Cinemas, Toronto, Ontario. 2005 - Save the Children Tsunami Relief Fund, The Arts Project, London, Ontario. 2005 - Black and White Exhibition, Shutter and Brush, Port Stanley, Ontario. 2001 - 2006 Visual Fringe, London, Ontario. Awards 2006 - Suncoast Insurance - Purchase Award. - Paint Ontario 2005 - Purchase Award, Lambton Heritage Museum - Paint Ontario 2003 - Ontario Arts Council Exhibition grant 2001 - Ontario Arts Council Exhibition grant 1999 - Deans Hall, Art in the Heart of London. 1999 - Short Listed, RBC Great Canadian Printmaking Contest. Member London Arts Council President Board of Directors. St.Thomas - Elgin Public Art Center 2006 - Present Vice President - St. Thomas - Elgin Public Art Center. 2005-2006 President - Port Stanley Artist Guild 2005-2006 Representation Museum London, Gift Shop and Art Rental. London Ontario Karger Gallery, Elora, Ontario. St. Thomas - Elgin Public Art Center, One of a Kind Gift Shop. Eldon Gallery, 14 King St. N., Waterloo, Ontario. Experience 2006 - 2000 - Volunteer - London Visual Fringe - Trooper 2006 - The Healing Palette - St. Joseph - Health and Science Centre- Exhibition of Art work, Healing nature of Art. Juror. 2006 - "Celebrating the power of Women" - Community Art Project YWCA - Facilitator, Instructor. 2006 - Present - President - St. Thomas - Elgin Public Art Centre, Ontario. 2005 - "Raise" - Exhibition from the Permanent Collection. St. Thomas - Elgin Public Art Centre, St. Thomas, Ontario. Guest Curator. 2005, 2006 - Chair, Organizer, Port Stanley Artists' Tour. Ontario. 2005 - 2006 President, Port Stanley Artists' Guild, Port Stanley, Ontario. 1996- 2006 Head Designer - Fellows' Flowers. 175 Sunset Drive. St. Thomas, Ontario. 2006 - Art Novella - Out Door Exhibition, Qui du vin. - June 15. Judge. 2006 - Guest Speaker - Brush and Pallet - London, Ontario. 2006 - Guest Speaker - Lambeth Artist Guild, Lambeth, Ontario. 2003 - Clark McDougal Scholarship - Juror 1997 - Wood Block Printing with a colorful Difference - Instructor. 1997 - Guest Speaker - Port Stanley Artists' Guild, Port Stanley, Ontario. 1992- 1993 - Vice President - Visual Art Society, University of Windsor, Ontario. 1992 - Annual Print Making Exhibition, Lebel Gallery, University of Windsor, Ontario. Guest Curator 1992 - Art Gallery of Windsor - Docent - guided tours Collections St. Thomas - Elgin Public Art Centre Permanent Collection University of Windsor - Permanent Collection Lambton Heritage Museum - Permanent Collection Sun Coast Insurance - Private Collection Dr. Bruce Pellow - Private Collection Dr. Telford - Private Collection Dr. Steve Phelan - Private Collection Dr. William Thorpe - Private Collection Elizabeth Ingolfsrud, Art Gallery of Ontario - Private Collection Dr. J Hofhuis - Private Collection
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ZYZZYVA EventsSeptember 26, 2017
In Conversation with Matthew Zapruder
Location: 7 p.m., City Lights Bookstore, 261 Columbus Ave., San Francisco
Description: Zapruder, the award-winning author of three collections of poetry, "American Linden," "The Pajamaist," and "Come On All You Ghosts," discusses his new book, "Why Poetry?" (Ecco), with Managing Editor Oscar Villalon. Free. For more info: http://bit.ly/2tKf88lOctober 6, 2017
In Conversation with Akhil Sharma
Location: 12:30 p.m., Mechanics' Institute, 57 Post St., San Francisco
Description: Sharma, the author "Family Life," a New York Times Best Book of the Year and winner of the International DUBLIN Literary Award and the Folio Prize, will discuss his new book, "A Life of Adventure and Delight," with Managing Editor Oscar Villalon. Free for ZYZZYVA readers. More info here: http://bit.ly/2f8IfwZOctober 14, 2017
ZYZZYVA Fall All-Stars at Lit Crawl
Location: 8 p.m., Dog Eared Books, 900 Valencia St., San Francisco
Description: A reading from past, recent, and near future contributors Michael Jaime-Becerra, Suzanne Rivecca, W.S. Di Piero, Greg Sarris, and Kelly Cressio-Moller. Free. For more info: http://sched.co/BGmL
ZYZZYVA e-mail updates
Tag Archives: Swing Time
The Push and Pull of Forming an Identity: 'Swing Time' by Zadie Smith
If it weren't for the prologue in Zadie Smith's new novel, Swing Time (464 pages; Penguin Press), a reader might be confounded by the many undulations the narrative takes as it kicks off in the present then looks back upon a past traumatic incident, excavating it. What could have been off-putting proves to be an adventure zig-zagging from public housing to brownstones, from England to Senegal, from 1982 to 2008, filling in the gaps in time and place and creating a definitive arc, albeit one completely warped. Relationships, and the action that subsequently alters them, form the novel's backbone, cementing the nonlinear …Continue reading
Posted in Book Reviews Tagged dancers, London, novel, Swing Time, Zadie Smith Leave a comment


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4 bedroom detached house for saleTreacle Farm Carr House Lane, Hollingworth, Hyde, SK14
Do you like this property?
Call: 01457 363028
Property Description
Key features
- Detached Family Home
- EPC Grade = E
- Farm Conversion
- Four Bedrooms
- No Vendor Chain
- Viewing Highly Recommended
Full description
***NO VENDOR CHAIN*** A truly stunning and beautifully presented Farm conversion which is finished to an extremely high standard. Offering an array of traditionally styled features with superbly proportioned accommodation throughout only an internal inspection will truly reveal what this property has to offer. Situated within a secluded location off the beaten track surrounded by open fields and countryside. The property is within easy access to transport links such as the M67 motorway and is conveniently located close to Mottram and Hollingworth villages. The accommodation comprises of; an external storm porch, 25ft lounge with access to the dining room, the lounge also flows to a great size and well designed dining kitchen, utility and ground floor wc. To the first floor there are four superbly proportioned double bedrooms with an en-suite off the master bedroom plus a main family bathroom. Externally there are large gardens surrounding the property with access to additional land to the extent of 3 acres which is available by separate negotiation.
EPC Grade = E
From our office in Glossop proceed down the main road away from the town centre. Continue along the road towards Hadfield and pass Glossop Caravans on the left. At the mini roundabout turn left on to Woolley Lane. At the lights turn left on to Mottram Moor continue along and take the next left turn onto Carrhouse lane, after a short distance the property can be found on the left hand side.
first floor
Entrance Storm Porch
Oak timber frame, half height brick wall with slate roof, seating, entrance doorway.
Lounge 15' 7" x 25' 5" (4.75m x 7.75m )
Window with solid door to front elevation, bi-folding doors to rear providing access to the decked area, central heating radiator, solid oak flooring, stairs to first floor landing with spindle balustrade, access to the dining room, a feature oak beamed arch providing an opening to dining kitchen.
Dining Room 15' 6" x 10' 8" (4.72m x 3.25m )
Window to front and side elevation, solid oak wood flooring, radiator.
Dining Kitchen 14' 8" x 19' 6" (4.47m x 5.94m )
Window to side elevation with bi-folding doors providing access to the decked area. A beautifully presented kitchen with a range wall and base units incorporating drawers, single drainer 1 and 1/2 bowl stainless steel sink unit, partly tiled walls, quality integrated whirlpool appliances, two built in ovens, fitted microwave, integrated dishwasher. A separate Island incorporating a four ring ceramic hob with stainless steel hood above, ceramic tiling to floor, a large wall mounted radiator, feature exposed brickwork, door to;
Utility Room
Window to side elevation, access door to rear, fitted wall and base units integrated washing machine, wall mounted central heating radiator, ceramic tiled flooring.
Ground Floor WC
Window to the front elevation, wc, wall mounted vanity wash hand basin with storage drawer below, illuminated mirror, partly tiled walls, a feature ladder style towel rail and extractor.
Exposed brickwork from the stairs area, exposed beams, access to all rooms.
Master Bedroom 15' 1" x 14' 6" (4.6m x 4.42m )
Two windows to the rear and side elevations, exposed structural oak 'A' frame and beams to the ceiling, wall mounted radiator, door to;
En-Suite Shower Room
Window to the side elevation, shower enclosure, wc, wall mounted wash hand basin with illuminated mirror, auto extractor.
Bedroom 11' 1" x 15' 5" (3.38m x 4.7m )
Windows to the front and rear elevations, inset exposed beam, radiator.
Bedroom 10' 9" x 15' 6" (3.28m x 4.72m )
Windows to the front and rear elevations. Views over the open countryside can be appreciated from the rear window.
Bedroom 10' 4" x 11' 4" (3.15m x 3.45m )
Window to front elevation, inset exposed beam to ceiling, radiator.
Bathroom / WC
Window, a suite comprising of panelled corner bath, shower enclosure with mains shower, wc, wall mounted wash hand basin with illuminated mirror above, ladder style radiator, tiling to walls with ceramic tiling to floors.
To the outside the property has a large driveway providing off road parking for numerous vehicles with substantial lawned gardens surrounding the property. There are areas of slate chippings providing a low maintenance garden plus a large raised decked seating area. The aspect of the garden is open to surrounding fields with stunning views of the open countryside. Additional land of upto 3 acres can be purchased by separate negotiation.
We endeavour to make our sales particulars accurate and reliable, however, they do not constitute or form part of an offer or any contract and none is to be relied upon as statements of representation or fact. Any services, systems and appliances listed in this specification have not been tested by us and no guarantee as to their operating ability or efficiency is given. All measurements have been taken as a guide to prospective buyers only, and are not precise. Please be advised that some of the particulars may be awaiting vendor approval. If you require clarification or further information on any points, please contact us, especially if you are traveling some distance to view. Fixtures and fittings other than those mentioned are to be agreed with the seller.
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Energy Performance Certificate (EPC) graphs
Listing History
Nearest stations
- Dinting (1.4 mi)
- Broadbottom (1.4 mi)
- Hadfield (1.4 mi)
Nearest schoolsUse the school checker
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Nearest stations
- Dinting (1.4 mi)
- Broadbottom (1.4 mi)
- Hadfield (1.4 mi)
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Market Info
Disclaimer - Property reference 200791473. The information displayed about this property comprises a property advertisement. Rightmove.co.uk makes no warranty as to the accuracy or completeness of the advertisement or any linked or associated information, and Rightmove has no control over the content. This property advertisement does not constitute property particulars. The information is provided and maintained by Reeds Rains , Glossop. Please contact the selling agent or developer directly to obtain any information which may be available under the terms of The Energy Performance of Buildings (Certificates and Inspections) (England and Wales) Regulations 2007 or the Home Report if in relation to a residential property in Scotland.
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ImmunoBiology Ltd
ImmunoBiology Ltd
Colaco C.A.,ImmunoBiology Ltd |
Bailey C.R.,ImmunoBiology Ltd |
Walker K.B.,405 Research Boulevard |
Keeble J.,UK National Institute for Biological Standards and Control
BioMed Research International | Year: 2013
Adjuvants were reintroduced into modern immunology as the dirty little secret of immunologists by Janeway and thus began the molecular definition of innate immunity. It is now clear that the binding of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) on antigen presenting cells (APCs) activates the innate immune response and provides the host with a rapid mechanism for detecting infection by pathogens and initiates adaptive immunity. Ironically, in addition to advancing the basic science of immunology, Janeway's revelation on induction of the adaptive system has also spurred an era of rational vaccine design that exploits PRRs. Thus, defined PAMPs that bind to known PRRs are being specifically coupled to antigens to improve their immunogenicity. However, while PAMPs efficiently activate the innate immune response, they do not mediate the capture of antigen that is required to elicit the specific responses of the acquired immune system. Heat shock proteins (HSPs) are molecular chaperones that are found complexed to client polypeptides and have been studied as potential cancer vaccines. In addition to binding PRRs and activating the innate immune response, HSPs have been shown to both induce the maturation of APCs and provide chaperoned polypeptides for specific triggering of the acquired immune response. © 2013 Camilo A. Colaco et al.
Colaco C.A.,ImmunoBiology Ltd |
Macdougall A.,European Bioinformatics Institute
FEMS Microbiology Letters | Year: 2014
Molecular chaperones are defined as proteins that assist the noncovalent assembly of other protein-containing structures in vivo, but which are not components of these structures when they are carrying out their normal biological functions. There are numerous families of protein that fit this definition of molecular chaperones, the most ubiquitous of which are the chaperonins and the Hsp70 families, both of which are required for the correct folding of nascent polypeptide chains and thus essential genes for cell viability. The groE genes of Escherichia coli were the first chaperonin genes to be discovered, within an operon comprising two genes, groEL and groES, that function together in the correct folding of nascent polypeptide chains. The identification of multiple groEL genes in mycobacteria, only one of which is operon-encoded with a groES gene, has led to debate about the functions of their encoded proteins, especially as the essential copies are surprisingly often not the operon-encoded genes. Comparisons of these protein sequences reveals a consistent functional homology and identifies an actinomycete-specific chaperonin family, which may chaperone the folding of enzymes involved in mycolic acid synthesis and thus provide a unique target for the development of a new class of broad-spectrum antimycobacterial drugs. Sequence comparison of the multiple Mycobacterial GroELs identifies two families with distinguishable by their C-terminal sequences. One of these is specific to mycobacteria and thus presents a novel drug target for anti-mycobacterial agents to treat TB, leprosy and Buruli ulcers. © 2013 Federation of European Microbiological Societies.
Mcnulty S.,ImmunoBiology Ltd. |
Colaco C.A.,ImmunoBiology Ltd. |
Blandford L.E.,ImmunoBiology Ltd. |
Bailey C.R.,ImmunoBiology Ltd. |
And 2 more authors.
Immunology | Year: 2013
Heat-shock proteins (hsp) provide a natural link between innate and adaptive immune responses by combining the ideal properties of antigen carriage (chaperoning), targeting and activation of antigen-presenting cells (APC), including dendritic cells (DC). Targeting is achieved through binding of hsp to distinct cell surface receptors and is followed by antigen internalization, processing and presentation. An improved understanding of the interaction of hsp with DC has driven the development of numerous hsp-containing vaccines, designed to deliver antigens directly to DC. Studies in mice have shown that for cancers, such vaccines generate impressive immune responses and protection from tumour challenge. However, translation to human use, as for many experimental immunotherapies, has been slow partly because of the need to perform trials in patients with advanced cancers, where demonstration of efficacy is challenging. Recently, the properties of hsp have been used for development of prophylactic vaccines against infectious diseases including tuberculosis and meningitis. These hsp-based vaccines, in the form of pathogen-derived hsp-antigen complexes, or recombinant hsp combined with selected antigens in vitro, offer an innovative approach against challenging diseases where broad antigen coverage is critical. © 2013 John Wiley & Sons Ltd.
Agency: GTR | Branch: Innovate UK | Program: | Phase: Smart - Proof of Market | Award Amount: 24.50K | Year: 2013
Vaccines are not yet available to protect against H. Pylori and C. Difficile and the existing therapeutic options available have significant limitations and challenges. Although quoted as significant, the market size for vaccines against these pathogens are poorly defined and the characteristics of a successful prophylactic vaccine product (e.g. production costs, duration of action) are not well established. ImmunoBiology Ltd (ImmBio) intends to establish the market size, intellectual property position and medical need for two potential new vaccines against these pathogens as a necessary first step to establishing full vaccine development projects. Vaccine development activities are both long and costly, therefore it is essential to establish proof of market including commercial viability before significant experimental work is initiated. A full exploitation plan will be established as a part of this project defining the work and costs that will be necessary to bring an effective vaccine to market. Activities will be based on an existing vaccine technology platform ImmBioVax owned by ImmunoBiology and proven to deliver vaccines possessing broad efficacy against pathogens such as N. Meningitidis and Mtb.
Agency: GTR | Branch: Innovate UK | Program: | Phase: Feasibility Study | Award Amount: 146.99K | Year: 2013
Immunisation programmes have proven successful against some of the world's most deadly diseases but unfortunately vaccines are not available to protect against many existing infections and new vaccine approaches are required urgently to prevent evolving and emerging diseases. For example, vaccines are not available to protect against some strains of bacteria that cause pneumococcal disease (including pneumonia and meningitis). Between 5-10% of all adults and 20-40% of children are carriers and Pneumococcal disease causes more infant mortality than TB, HIV and malaria combined. Existing vaccines are very expensive and cover only a limited number of pathogenic strains. This project will develop an innovative approach for a broadly protective vaccine "PnuBioVax" effective against all disease causing S. pneumoniae strains.
Agency: GTR | Branch: Innovate UK | Program: | Phase: Collaborative Research & Development | Award Amount: 490.00K | Year: 2012
Vaccine immunisation programmes have proven successful against some of the world's most deadly diseases, eradicating smallpox and on the edge of eradicating Polio. Unfortunately, vaccines are not available to protect against many existing infections and new vaccine approaches are required to stop evolving and emerging diseases. For example, while vaccines protect against some strains of bacteria that cause meningitis, group B meningococcal disease has proved difficult to combat. The Meningitis Research Foundation estimates that there are around 3,300 cases of bacterial meningitis and associated septicaemia every year in the UK and Ireland. No protective vaccine is available against the major B group strains in the UK and infection can often be fatal or lead to significant brain damage and/or limb amputation. This project will develop a new approach to produce a universal vaccine "MenBioVax" effective against all invasive meningococcal disease.
IMMUNOBIOLOGY Ltd | Date: 2010-06-21
The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture, typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromatography based methods, wherein a modified buffer solution is used which results in the purified stress protein complexes being more immunogenic than protein complexes obtained using conventional methodology. The purified complexes can be used to produce improved vaccine preparations which elicit enhanced immune responses in the subjects to whom the vaccine compositions are administered.
Immunobiology Ltd | Date: 2012-05-11
The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion protein may further comprise a linker sequence or hinge portion which joins the Fc receptor binding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.
Immunobiology Ltd | Date: 2012-03-23
The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular, there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimuli. The invention further extends to the use of heat shock protein complexes produced according to the methods of the invention in the preparation of vaccine compositions for the prevention and treatment of infectious diseases and cancerous conditions.
PubMed | Murdoch Childrens Research Institute, ImmunoBiology Ltd., University of Melbourne and Norwegian Institute of Public Health
Type: Comparative Study | Journal: Vaccine | Year: 2016
Neisseria meningitidis are common colonizers of the human nasopharynx. In some circumstances, N. meningitidis becomes an opportunistic pathogen that invades tissues and causes meningitis. While a vaccine against a number of serogroups has been in effective use for many years, a vaccine against N. meningitidis group B has not yet been universally adopted. Bacterial heat shock protein complex (HSPC) vaccines comprise bacterial HSPs, purified with their chaperoned protein cargo. HSPC vaccines use the intrinsic adjuvant activity of their HSP, thought to act via Toll-like receptors (TLR), to induce an immune response against their cargo antigens. This study evaluated HSPC vaccines from N. meningitidis and the closely related commensal N. lactamica.The protein composition of N. lactamica and N. meningitidis HSPCs were similar. Using human HEK293 cells we found that both HSPCs can induce an innate immune response via activation of TLR2. However, stimulation of TLR2 or TLR4 deficient murine splenocytes revealed that HSPCs can activate an innate immune response via multiple receptors. Vaccination of wildtype mice with the Neisseria HSPC induced a strong antibody response and a Th1-restricted T helper response. However, vaccination of mice deficient in the major TLR adaptor protein, MyD88, revealed that while the Th1 response to Neisseria HSPC requires MyD88, these vaccines unexpectedly induced an antigen-specific antibody response via a MyD88-independent mechanism.N. lactamica and N. meningitidis HSPC vaccines both have potential utility for immunising against neisserial meningitis without the requirement for an exogenous adjuvant. The mode of action of these vaccines is highly complex, with HSPCs inducing immune responses via both MyD88-dependent and -independent mechanisms. In particular, these HSPC vaccines induced an antibody response without detectable T cell help.


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The clip car chase Part 2 from Dazed And Confused (1993)
Categories movie-clips
Tags car, chase, part, and, confused, 1993, dazed
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Moments like this are extremely impressive, this shows how smart dogs are if you train them.
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Well this is the first time I've ever seen someone start a car like that. Maybe you can learn something here, if you're ever in a similar situation. O ...
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Ylvis and Calle has combined a small electric car with a very loud car horn.
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A racecar plummets nearly thirty feet while being lifted without proper restraints.
38,386 |3
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Hope For Paws and the L.A. Fire Department saving an injured Mastiff from the L.A River
Another great rescue by Hope for Paws. I'm so glad Eldad posts these so I can share them with you. I just love how patient and caring he is with these scared dogs. Another testimony to the value of a … Continue reading
Little Paws Dog Park in the 9th Ward brings people and pets together
Little Paws Dog Park in the 9th Ward brings people and pets together The grand opening of the 9th Ward dog park at 4517 Robertson Street in New Orleans Monday, January 26, 2015. Music by Tanya and Dorise. Plus, lots … Continue reading
Shorty Rossi to Attend A Cause 4 Paws Fundraiser
Pit Boss star Shorty Rossi, who has helped to make great strides in promoting a positive image of dogs who are so often unjustly hounded by people's prejudice, will attend a day of dogged… [[ This is a summary only. … Continue reading
Two Towers Four Paws
A beautiful blog by Teri Modisette Eleven years ago today, the Twin Towers slipped from the sky and plummeted to earth as America watched in shock. As that once beautiful Autumn day wore on to evening, news outlets reported many people … Continue reading
Celebrity Catwalk's Paws in the City Event June 1st
On June 1st couture-conscious canines will prove that compassion is always in fashion as they 'put on the dog' for a good cause at Paws in the City, a Celebrity Catwalk event. Stepping… [[ This is a summary only. Click … Continue reading
Puppy Paws
drew_138 Cutest puppy paws on the sweetest little sleeping puppy The post Puppy Paws appeared first on A Place to Love Dogs. A Place to Love Dogs
Picassos By Paws, Oct. 28, Houston, TX
Drawing attention to a paws cause, artistic tail-waggers are invited to unleash their inner Leonardog da Vinci or Henri Mutt-isse at the 4th annual Picassos By Paws, an event that helps to paint a… [[ This is a summary only. … Continue reading


text: This is a Desktop Wallpaper Calendar with important festivals and auspicious dates associated with Hinduism in February 2010. The festival dates are based on Indian Standard Time. The theme of the wallpaper is Shivratri which falls on February 12, 2010.Click on the image for a larger view. Right click on the image and use the save as option.You may also like to readImportant festivals and auspicious days in February 2010


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German engineering giant Thyssenkrupp on Friday said they are in talks with other European companies including Tata Steel for consolidation of its steel making facility in Europe.
Speaking to reporters on the sidelines of a function to inaugurate a new elevator facility in Pune, Oliver Burkhard, a member of the executive board at Thyssenkrupp AG, said, "We expect consolidation in the European steel industry for steelmakers to stay afloat. We don't know when and with whom we will close the deal but we are in talks with other European steel companies and the status of a merger with Tata Steel UK is where it was."


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You can still eat delicious, healthy dinners during even the busiest days. These slow cooker Mexican recipes are all under 300 calories — and prep is a snap!
1. Slow Cooker Carnitas | 223 Calories
Rave Review: "This recipe is much easier using the slow cooker. It makes a great filling for tamales, enchiladas, tacos, and burritos. It's also great combined with your favorite barbecue sauce and served on buns." — Erin Parker
2. Slow Cooker Chicken Mole | 289 Calories
Rave Review: "A dark, rich, complex flavored mole recipe. I generally shred the chicken so it will soak up the mole sauce and serve it with warmed tortillas. Tailor it to your own level of hotness and/or cocoa/peanut flavor. Mole is a sauce that has a lot of variations." — ELAINE05
3. Charley's Slow Cooker Mexican Style Meat | 260 Calories
Rave Review: "Wonderful! We have used it shredded in burritos, enchiladas, nachos, omelets, and several casseroles that call for Mexican seasoned beef. It really makes a roast go a long way." — DBYATES
4. Slow-Cooker Chicken Tortilla Soup | 262 Calories
Rave Review: "This tortilla soup tastes better than anything you can get at a restaurant. And it's healthy too! Don't let the long list of ingredients fool you. All you do is dump everything into the slow cooker and walk away." — Elena
5. Chicken Taco Filling | 149 Calories
Rave Review: "This recipe is easy, yet delicious when used in tacos or other Mexican cuisine. Try it for enchiladas and nachos too." — Dianna Brown-Brenny
6. Andy's Spicy Green Chile Pork | 169 Calories
Rave Review: "AWESOME dish. So easy to make and so, so yummy. Cannot wait to make it again!" — Mama B.
7. Slow Cooker Beef Barbacoa | 292 Calories
Rave Review: "Very easy and very tasty. Great for parties. Set out tortillas and let your guests make street tacos." — Jeff Pogue
8. Chicken Enchilada Slow Cooker Soup | 186 Calories
Rave Review: "Added a can of rinsed black beans. It was DELICIOUS! And even better as leftovers." — akk85984
9. Slow Cooker Salsa Chicken | 148 Calories
Rave Review: "Easy to make, healthy, and full of flavor. Just put all the ingredients in a slow cooker and let the machine do the work. There are infinite variations as to how to use the finished product, and your family is guaranteed to like each one." — Carajeanne
10. Slow-Cooker Posole | 241 Calories
Rave Review: "By far the best slow cooker recipe I have made in a long time! It was rich, flavorful and hearty!" — kurlieq
11. Spicy Turkey Tacos | 251 Calories
Rave Review: A great way to use up leftover turkey (or chicken) meat!
12. Mexican Pintos with Cactus | 153 Calories
Rave Review: "Cactus leaves turned out great! After they were cooked, I added them to fajita veggies. Yum!' — Momi
13. Slow Cooker Cilantro Lime Chicken | 272 Calories
Rave Review: "So easy and so delicious! we served it over Mexican rice and black beans with a little cheese and sour cream." — Rae Barnes


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Program summary
Open the door to senior management.
The beauty of this program at USC is that you earn three prized professional memberships:
- Associate member of CPA Australia
- The Institute of Chartered Accountants
- The Institute of Public Accountants
The MPA opens many doors for you to work in senior management roles and build yourself a top notch career. You will qualify to work in roles such as Chief Financial Officer, Senior Business Strategist, a Chartered Accountant, or as a key professional in the fast growing wealth management sector.
This program covers the latest business and accounting issues. It's a comprehensive program that delivers accounting fundamentals, informatics, managerial finance, financial reporting, corporate reporting, issues in auditing practice, tax law and practice, the principles of economics and commercial law, and a research project.
Professional recognition
Graduates of the Master of Professional Accounting program will meet the educational requirements for admission as an associate member of CPA Australia, the Institute of Chartered Accountants in Australia, and the Institute of Public Accountants. To gain full membership, graduates must complete the requirements of the chosen professional body's qualification program. It is the responsibility of the student to confirm with the three Australian accounting bodies (CPA, ICAA and IPA) whether any credit granted will impact on their eligibility for professional association membership.
Admission requirements
Entry to the Master of Professional Accounting program will normally require:
- An AQF Level 7 Bachelor Degree (or equivalent)
- Students who have completed a Bachelor degree (AQF Level 7) or equivalent in the same discipline may be eligible to receive credit of up to 48 units (4 courses)
Application and admission advice
Contact Student Central
+61 7 5430 2890
Ground floor, Building C, Sippy Downs
Related news
11 August 2016
Shariq finds success in the city at USC SouthBank
A random internet search has taken Shariq Ghaznavi from working as a junior accountant in Karachi, Pakistan, to a study adventure in the heart of Brisbane.
19 April 2016
Accounting degree for USC SouthBank student
He lives at Woolloongabba, the home of Brisbane cricket, and loves playing as an all-rounder for his local club, but Pakistan's Farhan Ahmed found himself on another good wicket when he enrolled at the University of the Sunshine Coast in early 2014.
What will I study
Select your location, starting year and starting semester below to display your Recommended Study Sequence.
Program structure
Program Structure
Required courses (14)
ACC506 Accounting Fundamentals
ACC508 Informatics and Financial Applications
ACC510 Financial Reporting
ACC511 Managerial Finance
ACC520 Legal Regulation of Business Structures
ACC521 Corporate Reporting
ACC610 Strategic Management Accounting
ACC611 Taxation Law and Practice
ACC620 Contemporary Accounting Issues
ACC621 Issues in Auditing Practice
BUS501 Business Analytics and Statistics
BUS502 Principles of Economics for Accountants
BUS503 Principles of Commercial Law
PLUS select 1 course from:
MGT723 Research Project
MGT726 Managerial Project
Electives (2)
Select 2 electives from:
ACC701 Accounting for Managers
BUS702 Economics for Managers
BUS703 Managing Research
BUS704 Corporate Finance
BUS705 Innovation and Management Decision Making
BUS706 International Business Law and Ethics
BUS707 Managing Across Global Cultures
BUS708 International Trade and Finance
BUS710 Marketing in an International Environment
INF701 Management Informatics
MGT701 Managing Organisations
MGT702 Managing People
MGT703 Strategic Management
MGT704 Global Business Management
MGT711 Entrepreneurship and Venture Planning
MGT712 Corporate Governance, Ethics and Corporate Social Responsibility
MKG701 Marketing Management
Note: Program structures are subject to change. Not all USC courses are available on every USC campus.
Total units: 192
Recommended study sequence
Students who commenced prior to the current semester must complete the courses from their original program structure unless otherwise advised. For courses no longer included in the current sequence, use the course links in your structure for details of requisites and scheduling. This is a recommended study sequence to complete your program within the specified full-time duration.
Program requirements
In order to graduate you must:
- Successfully complete 192 units as outlined in the Program Structure
Program notes
- Completing this program within the specified (full-time) duration is based on studying 48 unit points per semester (normally 4 courses)
- Most courses are valued at 12 units unless otherwise specified
- Only a full-time study option is available to international students on a Student Visa
- Online study mode not available to international students on a Student Visa
- Refer to the Planning your study page to manage your progression
How to apply
Am I eligible to apply?
- Confirm that you meet the program specific admission requirements, prerequisites and recommended prior study outlined on Why study this program?
- Confirm that you meet the general postgraduate admission requirements and English Language Proficiency requirements
Domestic students
- Download and complete the Application for postgraduate coursework form and submit directly to USC.
- Lodge the completed application form with supporting documentation to Student Central by the due date.
International students
Apply direct to USC International
More information
- Search for answers and ask questions in askUSC
- Contact Student Central
International students should contact USC International
How to enrol
Refer to the Academic Calendar for key semester/session/trimester enrolment dates.
- Current students
- Step 1 - Enrol in your courses
- Step 2 - Select your class times
- How to enrol once Class selection has opened
- Headstart, Cross-institutional and Visiting students
- New students
- Plan your study
- Confirm your enrolment
- More information
Current students
Refer to the Academic Calendar for key semester/session/trimester dates.
Enrolling is a 2 step process:
Step 1 - Enrol in your courses
You can enrol in courses for Study period 2 now. This gives you the opportunity to plan your study well in advance.
Note: If you enrol in a course but don't select a class time (step 2), you'll be charged the fee for the course at census date. You can swap, drop or add courses up until the end of week 2, and remove courses from your enrolment up until census date. View key dates in the academic calendars.
View the instructions to complete Step 1 in the video below or the Enrol in your courses PDF guide.
Step 2 - Select your class times
Check the Academic calendar for the timetable release date for each study period. When the timetable has been released you can use the Timetable Planner* to plan your class times.
All students (excluding Headstart, Cross institutional and Visiting students)
Once Class selection opens*, select your class times in USC Central by following the instructions in the video below or the Select your class times PDF guide.
Tip: Select your classes as soon as Class selection opens as classes can fill quickly.
* We will be in contact with you to let you know when the Timetable Planner is available and Class selection opens.
How to enrol once class selection has opened
If class selection is open and you are yet to enrol in your courses, you can enrol in your courses and select your class times in one step.
Check the Academic Calendar for Class selection open date to confirm.
View the instructions in the video below or the How to enrol when class selection has opened PDF Guide (565KB).
Headstart, Cross-institutional and Visiting students
Complete and submit a Class preference form to select your class times.
New students
Domestic students: Once you have applied and received your offer of a place from USC, follow the steps for Getting Started at USC to respond to your offer, plan your study and enrol in your courses.
International students should view the Getting Started Guide for International students for enrolment steps.
Plan your study
Before you re-enrol it's important to plan your study to make sure you study the right courses at the right time so you can finish your degree when you plan to.
Follow the Planning your study instructions to plan your courses for the upcoming semesters/trimesters/sessions. You can vary your study load between full-time (3-4 courses) or part-time (1-2 courses) in each study period. If you need some assistance, contact Student Central.
Confirm your enrolment
View your class timetable in USC Central to confirm you are enrolled in the courses you selected. Close to the beginning of the semester/trimester/session, your course details can be found in My Courses in Blackboard.
To prove your enrolment to Centrelink, print an unofficial transcript from USC Central. Refer to the steps at View your Unofficial Transcript in the USC Central Guide.
Once you are enrolled, learn how to manage your enrolment.
More information
Search for answers and ask questions via askUSC, or contact Student Central.


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- labels: --> scintilla, indicators
- status: open --> open-works-for-me
- assigned_to: Neil Hodgson
In 3.4.1, drawing indicators was correctly done when calling SCI_SETINDICATORCURRENT and SCI_INDICATORCLEARRANGE.
After upgrading to 3.4.2, some indicators are still shown although "clear range" was called. Scrolling or displaying a tooltip makes the indicators being drawn correctly.
I haven't been able to reproduce the indicated problem. There are also no changes between 3.4.1 and 3.4.2 that look likely to impact this area.
Perhaps you could narrow the problem down to a particular revision by using Mercurial to choose individual revisions then building and checking them. Perform a binary search over the revision history. There are around 70 revisions between releases so it should only take 7 tests.
We found out that the bug was introduced with revision 5053:31871037ed1f
The method changed in this revision, RectangleFromRange, does define the area to be redrawn when indicators change so could lead to an area not being redrawn. However, I'm having a lot of trouble seeing how this revision could change the behaviour in the way described. The change here is to clip the top and right sides of the redraw rectangle to the rectangle returned from GetClientDrawingRectangle instead of GetTextRectangle.
GetClientDrawingRectangle differs significantly only on Cocoa where it has to handle drawing areas that are not currently visible. On Windows, it should return the same rectangle as GetTextRectangle except that the left and right sides haven't been moved in to allow for margins. Only the right side is subsequently used and it will differ from GetTextRectangle by vs.rightMarginWidth which is normally only a single pixel. Anyway, the result would be that RectangleFromRange causes a redraw for an area that is 1 pixel wider than before so any indicators redrawn before will still be redrawn after this revision.
I still haven't managed to reproduce the problem.
I can follow your reasoning -- it makes sense what you say. It did introduce the bug, though.
In order to give you a better understanding, we did a screen capture. The video is attached to this post.
In this example, we use indicators to highlight block starts and ends. When the caret is on a block keyword (if, else, end), the corresponding keywords are highlighted. As you see, when another block is selected, the previous indicators are still visible (except the one where the caret was last on).
When hovering over a variable, a tooltip is displayed which causes a redraw, so all indicators are correctly drawn again.
We set/clear the indicators in SCN_UPDATEUI.
Hope this helps!
In the video, fold highlighting is also changing the lines that are seeing the indicator fail to clear. There could be an interaction here and this could be checked by turning off fold highlighting.
Another thing to check is whether the right margin change is the cause by subtracting vs.rightMarginWidth from rc.right in RectangleFromRange.
Creating a small self-contained application that reliably demonstrates the issue would allow me to debug further.
There is a possibility here that the problem is inverted: your highlights should not have been visible before but were fortuitously made visible by another element updating. However, the clearing of the highlights is very similar to SciTE's highlight current word function which clears the highlights inside SCN_UPDATEUI but then waits for half a second before adding the new highlights.
Turning off fold highlighting makes the indicators being drawn correctly.
Potential fix in [23f89a]. The change to RectangleFromRange may be increasing the size of a redraw so that its bounding rectangle covers the entire client area. This then invokes an optimization in painting that will not test new area invalidations closely. However, when fold highlighting is on, the paint area is a complex shape with holes like a sideways 'T'. When the changes to indicators are in the holes, they are not painted but also are not seen as outside the paint area so do not trigger a complete redraw.
I tested your fix and things are looking good again :-) We will continue to use the patch when testing our software.
Thank you very much for your fix!
Log in to post a comment.


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3 — Seinfeld on Religion
Please respond to the following in a Google Doc (directions), and share it with Dr. Marshall. Also, before you begin, read the guide Writing about Film and TV.
David Marc, Jon Stratton, and Rosalin Krieger are all interested in Seinfeld's "Jewishness." Let's start with Marc.
David Marc, Jon Stratton, and Rosalin Krieger are all interested in Seinfeld's "Jewishness." Let's start with Marc.
- What does Marc mean that Jerry Seinfeld, both comedian and character, is the "least Jewish" and "most American" of his TV predecessors? Gimme three examples. Is there anywhere in "The Bris" where this idea manifests itself (actions, dialogue, etc.)?
- Jon Stratton claims that Seinfeld is not, as we recently discussed, "a comedy of manners," but is about ____, which is typical of American Jewish humor.
- At what point(s) in "The Yada Yada" does Jerry embody the term schlemiel in its original context (i.e., his "interacting with the dominant culture")? Explain your response.
- Which characters on Seinfeld are Jewish? And the actors in reality?
- What does Rosalin Krieger mean by "degrees of civility," and which Seinfeldian character(s) best represent(s) the minus side of the thermometer? Why? Explain using a couple of examples from "The Strike."
- What does Festivus represent, according to Eric Shouse and Bernard Timberg? Does this interpretation differ from your post-screening response?
Included periodically here, SeinPosts will fill you in on terms, cultural events, people, etc. with which you may not be familiar. While these questions may not make much sense out of context, they will after we watch the episodes in which they're referenced! SeinPosts should never take very long to answer.
- What's kasha?
- TV Guide is now housed online. How did people used to receive it?
- Who were The Ray Conniff Singers?
- What does kitschy mean?
- Who are Mark McEwan and Al Roker, and why might someone get them confused?
- What does the expression Indian giver mean?
- Who is Truman Capote?
- What's the Manhattan Project?
Grad Students Only...
- What three reasons does Jon Stratton offer as to why there so few Jewish women characters on TV in the 1990s? Do these support David Marc's argument about Jerry Seinfeld's "Americanized" Jewishness? If so, how? If not, why not?
- I have told colleagues that most of my knowledge of Jewish culture comes from Seinfeld and The Daily Show with Jon Stewart. While I'm mostly joking, there is some truth in that statement. Can you think of other television series and/or the characters therein that may be read as inherently Jewish, even if (like the Costanzas) they are not necessarily written as such?