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best going out dresses for all your special occasions
Long sleeve dresses are an excellent style of dress that can be used in many different environments and situations. They add extra warmth to your arms with the inclusion of sleeves, but are also appropriate during warmer seasons because the material is usually not all that thick. They provide a unique look compared to sleeveless dresses, short sleeved dresses or single-shoulder dresses and although they have become increasingly common, the likelihood that you will be the only girl at the event with a long sleeved dress on is still relatively high.
Drape long sleeve dresses are great for many different situations and are appropriate in both formal and casual occasions. These dresses are often loose fitting, and resemble a long sweater, but made out of much thinner material. They are great for dinner dates and family gatherings alike and you never have to worry about being overdressed. Typically drape long sleeve dresses will be one solid color and will not have too much in way of a design, but there are always exceptions to that rule.
Form fitting dresses work in most occasions and will help you to look your best any event. Form fitting dresses are very common, but are not often used in combination with long sleeves which will give your dress a very unique look. These dresses are typically more shortly cut than other types of long sleeve dresses, so keep that in mind if you are attempting to avoid showing too much leg.
These dresses are very common. There was a time when most long sleeve dresses were considered to be formal, and although that perception has changed over time, the fact remains that they do work very well in many social situations. They provide a "grown" look that shows that you do not feel that you have to show a lot of skin in order to look your best. Most formal dresses will keep it light in terms of design, but may feature a small design with some lace or frill to add extra flavor to the dress. When combined with an impressive pair of heals you will turn heads and show-stop throughout the night.
One-shoulder long sleeve dresses are a style of dress that became popularity in the late 1980s and throughout the 1990s and has remained a popular style of dress ever since. One arm will be completed covered while the other arm, and accompanying shoulder, will be bare. These give you a formal look while allowing you to show off a sense of style and show some skin at the same time. These tend to be considered on the sexier end of the spectrum in regards to long sleeve shirts, and are excellent for many different situations including formal and informal gathering, so you really do not have to worry about looking like you overdressed for the event.


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The Red or Dead Mr Crooks arrives on the scene to keep your feet firmly on the ground. The Rose Derby shoe features a smooth tan leather upper, featuring perforated detailing at the toe. Stitched overlays and a chunky rubber sole finish nicely.
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Nearly three years after President Obama removed our last troops from Iraq--opening the door from groups such as the Islamic State--he is sending more soldiers there.
As for the troops he yanked, it was something Obama bragged about during the 2012 presidential election.
This summer Obama redeployed some soldiers to Iraq--and 1,500 more are headed to the war-torn nation..
Of course Obama waited until after the midterms to for the latest move.


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I'm taking a break from Guild Wars 2, perhaps permanently. I've had a shift in perspective over the last couple of months. I presume it must be something to do with that fabled mid-life crisis that pops up in movies and elsewhere. The gist of the matter is that my priorities have reshuffled such that I am interested in exclusively playing games which are compelling and exceed my personal entertainment threshold. The mindless zerging and open world freneticism of Tyria are entertaining, to a degree, but they are neither extraordinary nor compelling. I have uninstalled the game on the principle of "out of sight, out of mind." This is a bit of conceptual simplification which in my personal case allows me to devote more mental energy to my children and to games which give me exactly the experience I want. I also took the nuclear route of deleting all of my characters. All of them. It goes hand-in-hand with divesting myself of my previous online persona which was tied too tightly to a specific game. I've since adopted a game-agnostic alias which is the name of a fictional character I came up with fifteen or so years ago for a novel I've never written. It's that old Buddhist mantra in action: "Take what is useful and discard the rest."
If ArenaNet ever returns to its original design philosophy I may return. It would be with brand new characters using brand new names without any sort of back-story empire mandating their continual grooming and cultivation. I would be perfectly happy to roam the lands as a fresh-faced staff Elementalist if the Marionette were to make a reappearance. Bring Scarlet Briar back from the dead and burn down another city or even an entire zone. Give the plot some fangs. I already know we're going to kill all the Elder Dragons; why not do it in style? You took my suggestion to heart and did it in the cheesiest way possible. (Bottom of the post, Heart of Thorns main story spoilers.) Your storytelling simply isn't up to the task. That's why I'm playing The Secret World and relishing the main plot line. The side stories are quite fascinating as well. It's a dark, adult horror novel without plot armor. People die, just like I wish they would.
You know, I can ignore story, but I must have compelling gameplay. That's why I'm playing Smite for my PvP desires as opposed to the pendulum-driven non-balance of GW2's structured PvP. Smite has an audience of 10 million viewers and players (by comparison, League of Legends has 67 million) and offers cash prizes at its world championships. It isn't just a marketing strategy, either, as ArenaNet's eSports ventures are. Balance is therefore of primary concern. I am thriving in an environment in which mechanical mastery is fairly straightforward, passive/active item builds are flexible, and team efforts are paramount. It is a game unto itself rather than a game mode in a larger setting. It is this combination of features that have endeared it to me and motivate me to become better at it.
When it comes to World versus World action, I'm putting my money on Crowfall. Literally. My spouse handed me some of the winnings from her personal vice and told me to spend it on my personal vice. I therefore went straight to the Crowfall website and became a backer. It is a campaign-driven, player-combat-focused environment which promises to provide everything anyone could be looking for in an epic-scale fighting experience: meaningful permanence with a definite end-state, account-level skill progression (crows), character-level customization (vessels) and variable rulesets and arenas from the PvE-centric Eternal Kingdoms to the PvP-centric Dregs in which Scree's guild Obsidian will be operating. The people who make Crowfall understand that player combat is the engine of the game. The people who make EVE understand that spaceship explosions drive pretty much everything, including the economy. I'm talking about a game that is designed with good fights in mind and is not simply an exercise in "look at the pretty PvE maps we made!"
World versus World in GW2 is nice, mindless fun, but does not provide me with the meaningfulness I am looking for, nor does it seem to understand that not having convenient access to enemy players means fewer player fights and therefore no game mode. Had the Air Keep been designed with player fights in mind, it would not feature gusts of wind that knock you off narrow platforms which makes it harder to fight players. A dynamic, triggered event, for example, could allow attackers to glide over the keep (rented gliders for non-HoT owners) and bomb it while the defenders use a variety of mortars, cannons, and other projectile siege to shoot them down. Had the Earth Keep been designed with player fights in mind, it would not feature earthen wall mazes which make it harder to reach other players and fight them. They would feature, for example, Auric Basin-style suits which would allow players to costume brawl in the style of the Trinity so that players could experience a temporary Tank-Damage-Heal battle as an alternative to having to raid to get their Formally Designated Roles fix.
Don't get me started on raids. Instanced content in a game which is supposed to be about a free-form, at-your-leisure experience in which you meet strangers and cooperate with them to great effect. "Fix your parse" is not something I ever want to hear in map chat. Hells to the noes. My personal theory is that there is an egomaniac behind the scenes calling the shots and compromising the overall direction projected by the exquisite, organic maps and epic music and all the other lovely things created by the beautiful and talented people who work at ArenaNet, many of whom I admire greatly. It seems NCSoft's studio babies past and present have a problem with egomania and squandered potential. Hardly endemic to that particular publisher, but I digress.
These concerns are secondary, however. Perhaps even tertiary. It's a personal decision, one that was not made lightly. I no longer care to spend my time on games that don't satisfy my personal enjoyment criteria. Perhaps when my children are grown I'll have thirty MMO icons littering my desktop once again. Right now, my time is precious and I won't spend a second of it on checklists or preparatory work or grinding as primary activities.
Which means, of course, that I'm heading straight back to Egypt in The Secret World.


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Gohara leaves nerves, walks behind for 1st W
After shaky MLB debut, Braves prospect outduels Scherzer, doesn't issue free pass
WASHINGTON -- Luiz Gohara admits that nerves may have gotten the best of him when he made his big league debut last week against the Rangers. But in Wednesday's 8-2 win over the Nationals, the 21-year-old lefty showed the Braves exactly why many think he has promising upside.
The 6-foot-3, 210-pound flamethrower earned his first win as a big leaguer, throwing six innings of two-run ball (one earned) in just 71 pitches. He scattered six hits, struck out six, and most impressively, walked none.
"The kid gets locked in and really competes," manager Brian Snitker said. "And that's what I heard about him from the guys that played with him, the guys that have had him, been around him. They say once he gets out there, he's trying to beat you. That's legit stuff right there, too."
"It feels really good," Gohara said. "It's kind of emotional for the first one ... for the first year being here, it's really fun to have the first win in the big leagues."
Gohara walked four against Texas. With his control issues behind him, Gohara settled down his second time out and showed off the repertoire that made him the Braves' No. 7 prospect, according to MLBPipeline.com. His fastball touched 98 mph, and he used his slider in two-strike counts to finish off hitters. And to do it against one of the best lineups in baseball showed his stuff plays in the Majors.
"He was pretty awesome," shortstop Dansby Swanson said. "He was able to locate his stuff. I think the efficiency is what impressed me the most. ... If you can do that, especially with power stuff, a guy that can get some swings and misses and stuff like that, you're definitely on the right track."
The icing on the cake for Gohara was that he was outdueling reigning National League Cy Young Award winner Max Scherzer.
"To get the win on him is something really big for me," Gohara said smiling. "I always wanted to pitch against the Nationals and have him pitching for the other side."
With his first win in hand, the lefty -- who some have compared to CC Sabathia -- will have a few weeks left this season to build off it. If he can, the Braves may have a key building block for their future starting rotation.
"There's a lot to like there," Snitker said.
Daniel Shiferaw is a contributor to MLB.com based in Washington who covered the Braves on Wednesday. This story was not subject to the approval of Major League Baseball or its clubs.


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CHAMPIONS #10Jul. 1st, 2017 09:19 pm
Preview images at CBR; Newsarama
STORY BY: Mark Waid
ART BY: Humberto Ramos and Victor Olazaba
COLORS BY: Edgar Delgado
LETTERS BY: VC's Clayton Cowles
COVER BY: Humberto Ramos and Jim Lee
PUBLISHER: Marvel Comics
Summary: SECRET EMPIRE TIE-IN! The Champions are put to the ultimate test. This is no small-town problem they're facing – it's up to them to help right an entire world turned upside down!


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If this is your first time here or you have not read my blog for awhile my InterStim journey blogs started back on 11-29-10 and posted through 12-16-10. I may be off a couple days in Dec but it is close. I have logged my journey with both stage 1 and stage 2 of the surgeries.
It is DAY 34 after stage 2 surgery. has it worked awesome? Not awesome but at least 50% better, so that is definitely a plus. What is working is for the incontinence, perfect, it is gone! As far as the over active bladder part…not so much. Don't get me wrong, like I said it is better but still not where it should be.
I have good days and bad days meaning that some days I really notice that I am not in the bathroom so much and other days it is like I was prior to surgeries. For the most part we are about half and half meaning part of the day is good and the other part I pee a lot still.
I went to my Urologist yesterday for my post opp appointment and he put me back on enablex but instead of the 15mg that I was in prior to surgery, it is 7.5mg. I was/am a little bummed about this as the whole point of surgery was to get of of meds and now I am frustrated that I am taking them again. A smaller does is better but still, ugh!
I had turned up my InterStim to about 4.0 and he does not want me to take it up much more so that is why he suggested the meds. We can still do some fine tuning on the programming but since I am not experiencing good enough results he feels I may still need the meds even with the fine tuning.
Pros of my surgery:
I can work out without peeing myself, so I can jump again.
Half the time it is better, that is still better then before surgery
I have gone on drives for 2.5 hours without stopping to go to the restroom.
When it is a good day, I notice it and it feels awesome!
Cons of my surgery
Only works half the time, of course I was hoping for more.
Still having to fool around with medications.
Feeling down and out on those off days and this is not fum.
So was the surgery worth it? Oh yes I still believe it was a great thing for me. The pros out weigh the cons and even my cons are better then they were before the surgery. I have had bladder issues since I was born. I was not one of those that only had problems after kids or later in life. I have had bladder issues ALL my life. I know that not many people can say that so I knew going into anything that it would be hard to treat me.
Would I still recommend this surgery? Yes I would as long as someone does their research on both the surgery and on their own personal issue as just like anything else, it is not for everyone.
I will keep you posted on what happens with adding the meds!
One thing I am dreading with the meds is that when I am on them I am constipated a lot. I did get this under control with extra fiber pills but since I have been of the meds i have not had to take any extra fiber. Hopefully the lower does works so I won't be as bad this time!
Never know when the good day will be.
Come back often as I will always be updating my progress. You never know when I will post about it because I don't know!! LOL


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Wednesday, October 20, 2010
Finished Object: Stegosaurus Hat
I finished up Mr. S's Stegosaurus Hat yesterday, and surprised him with it when I picked him up from school. He has been so excited about this hat, and when I put it on him and he pranced out into the playroom with it, a bunch of boys gathered around him and started touching the spikes and asking questions about it.
The whole walk home Mr. S was a Stegosaurus. He walked like he thought a Stegosaurus would walk and roared at nearly everyone we passed on the sidewalk. When we got home I had to make him stop trying to eat the plants out of the back yard.
The pattern came from Tot Toppers and was easy and so much fun to make. Last year I made two adult sized Stegi hats for friends. They look just as cool on grown people too!
Labels: Knitting
1 comment:
- Kimberly said...
That is THE cutest thing I have ever seen! I love the photo where Seamus is roaring, so cute!
- October 20, 2010 at 11:53 PM
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Based on RePEc, it indexes over 2,200,000 items of research, including over 2,000,000 that can be downloaded in full text.This site is part of a large reseaech effort to enhance thefree dissemination of research in Economics, RePEc, which includes bibliographic metadata from over 1,900 participating archives, including all the major publishers and research outlets. ixeas IDEAS is just one ideas for research papers in education several services that use RePEc data.Authors are invited to register with RePEc to creatPerhaps the most difficult part of getting started on a research paper is choosing the topic to write about.
We found 597 good research paper topics from a wide variety of subject areas.This page is all about helping you with ideas for research paper topics. Each of these topics can be a standalone subject for a research paper, or can give a general idea for a good place to start. It rexearch good to select a topic that is relevant to your life since you are going to spend a long time researching and writing about it. Perhaps you odeas considering starting your own business or ieeas a career in politics. Education Research Papers Education research paper topics offer education majors a choice of samples on how to write projects at any level.Education research paper topics offer education majors a choice of samples on how to write projects ranging from Adult Learning Theories to Early Education Literacy.
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What is Concierge Services?
Concierge Services is a done-for-you ONTRAPORT service that invites clients to purchase hours to apply towards ONTRAPORT related services. Projects involve the following types of work: Maintenance, Custom Building, Migrations, and Training.
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We can train single users or entire teams on the power of using ONTRAPORT in their business and help them learn the software so they can do things in their account on their own.
This entails moving processes built on other platforms into ONTRAPORT. We can recreate forms, emails, autoresponders, products, order forms, affiliate programs, landing pages, membership programs - as well as import contacts and lists. Other types of migrations that include credit card data, purchase history or affiliate data can be done via Custom Dev Work. Common platforms include but are not limited to:
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I lived in Texas for many years. As a matter of fact, my sweet baby girl was born outside of Dallas, Texas. My father, although born in Indiana, considered himself a Texan and loved to wear a big Cowboy Hat and boots every day! I guess you could say Texas and the South is in my blood!
If you had to name a quintessential Southern food, it would have to be Chicken Fried Steak. I love it!
For many years, Big has said, "No" to Chicken Fried Steak. I never really got a reason for the dislike of this wonderful dish.
Big's dislike, has turned into love! Why, you may ask? It is all because of Ree Drummond! Her recipe for Chicken Fried Steak is the best I have ever had. Better than some of what I ate in Texas. It is true!
Try it for yourself!
Chicken Fried Steak
Adapted From Ree Drummond
Serves 6
3 pounds cube steak
2 large eggs
1 1/2 cups milk
3 cups all purpose flour
2 teaspoons seasoned salt
3/4 teaspoons paprika
1/4 teaspoon cayenne pepper
1 1/2 teaspoons black pepper
1/2 cup canola or vegetable oil for frying
Latest posts by Cynthia (see all)
- Health Benefits of Eating Apples - September 18, 2017
- Chicken Pot Pie from Scratch – the best comfort food - September 13, 2017
- Broccoli Bacon Salad #InternationalBaconDay - September 1, 2017


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In case you're attempting to settle on an extraordinary family occasion, pick the Grand Canyon! Going by the Grand Canyon is a remarkable affair on account of how tremendous it genuinely is. Cut out of shake by the Colorado stream more than a huge number of years, it is completely staggering – like nothing you can envision. There are numerous exercises accessible, so your whole family will have a decent time.
On the off chance that you have availability issues you don't have anything to stress over. The Grand Canyon covers a gigantic territory, and offices will change contingent on the area, so you will need to check first. unique needs guests can get brief stopping licenses, and wheelchairs are offered for nothing out of pocket by the National Park Service. practicing canyoning in Mallorca
Furthermore, there are uniquely planned projects for guests that have exceptional requirements. There are a few neglects with fantastical perspectives that are wheelchair available. On the off chance that you have children, they will appreciate the instructive projects that are offered (you'll appreciate them as well). The ecological projects are particularly pertinent. You will figure out that it is so critical to protect the Grand Canyon.
These projects additionally clarify a portion of the secrets of the gorge in a way that even the most youthful of children will get it. One of the best projects for families is the Junior Ranger programs. Your children will have an awesome time taking part, and they will figure out how to help save our National Parks. They will recall and utilize this data their whole lives. Besides, there are a great deal of exercises in which they'll have a great time while finding out about the Grand Canyon. Therefore they'll progress toward becoming delegates of the Grand Canyon. They'll love the extraordinary identification they get after their swearing in function.
There's so much history you'll realize when you visit the Canyon. The way the Canyon was shaped over a huge number of years is astounding. You'll learn adjoin protection strategies and archeological review techniques that are being utilized today.
At that point there are the enterprises you can involvement on your family get-away. The Canyon offers climbing and hiking, biking, and whitewater boating along the Colorado River. These brave open air encounters will bring your family into a nearer comprehension of this remarkable region, while having the seasons of your lives.
In the event that you would prefer not to get out and investigate, you can visit the ravine in your vehicle. There are a considerable measure of territories at the Grand Canyon you can drive to. On the off chance that you choose to visit the territory along these lines, you needn't bother with any exceptional gear, you won't have long strolls or stress over the hot or chilly climate. Rather, you and your family will have the capacity to take in the greatness together in the solace of your auto.
In the event that you appreciate outdoors, the Grand Canyon offers superb outdoors openings, and it truly is the ideal place to go. You can browse tent outdoors at wonderful destinations, RV parks, and provincial lodges. Set up your campground, at that point take off for some fun outdoors exercises including climbing, swimming, and capturing the exquisite beautiful perspectives. A standout amongst the most loved exercises is the donkey ride to the base of the Canyon. On the off chance that this is something you need to do you'll need to reserve a spot numerous months ahead of time since it's so mainstream.
You will see astonishing natural life while you're at the Grand Canyon. It's a birder's heaven with roughly 355 sorts of winged animals. You'll find a plenty of warm blooded animals, reptiles, creatures of land and water, and five local types of fish. What an astonishing realizing open door for you and your family! As ponder of the Natural Wonders of the World, you will see regular elements found no where else on Earth, and find out about surprising sorts of rocks, abandon living space, and disintegration. You'll have recollections to endure forever when you take your family on a Grand Canyon get-away.


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I'm pretty sure this is the sweet iced tea I had with dinner at the teahouse. A squeeze of lemon gave it a summery feel. Strawberry flavor is strong but natural tasting and not overpowering.
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Hiding under a warm blanket until Spring. Just bring me hot tea and dark chocolate at regular intervals!
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The Destiny of the Unevangelized
- Introduction
- Excerpts from John Sander's classic work No Other Name
- Comments on John Sander's work
- Replies to Restrictivist objections
Can the unevangelized be saved? The unevangelized are people who have never heard about Christ or has insufficient information about Him. Can they be saved even though they have no opportunity to hear about the Gospel?
We believe that they can and such view is known as Inclusivism. Inclusivism teaches "that the unevangelized are saved or lost on the basis of their commitment, or lack thereof, to the God who saves through the work of Jesus. They believe that appropriation of salvific grace is mediated through general revelation and God's providential workings in human history. Briefly, inclusivists affirm the particularity and finality of salvation only in Christ but deny that knowledge of his work is necessary for salvation. That is to say, they hold that the work of Jesus is ontologically necessary for salvation (no one would be saved without it) but not epistemologically necessary (one need not be aware of the work in order to benefit from it)" (John Sander, No Other Name, p. 215).
John Sander defines terms finality and particularity as follows:
The term "finality" refers to the unsurpassibility and normativity of both the work (e.g., atonement) and the revelation of Jesus. The term "particularity" refers to the fact that the salvation provided by God is available only through Jesus. Jesus, as the Son of God, is the highest, clearest, and absolutely normative expression of the character of God. Furthermore, Jesus is the savior. There are no others. (John Sander, No Other Name, p. 26)
What follows is excerpts from John Sander's classic work No Other Name - An Investigation into the Destiny of the Unevangelized. After introducing Sander's biblical arguments for Inclusivism, we will deal with various objections.
[Return to the Content]
Excerpts from John Sander's classic work No Other Name
In making their case, inclusivists typically cite not only those texts affirming universally accessible salvation but also a variety of texts dealing with the character and will of God and his dealings with Gentiles.
The first group of texts
The first set of texts dealing with God's character and will focuses on God's extension of grace to all who believe in him. For example, 1 Timothy 4:10 ("because we trust in the living God, who is the Savior of all men, especially of those who believe") is interpreted as meaning that the living God saves all who believe in him and that the specific content of saving faith may vary so long as it is grounded in an essential trust in God. Texts referring to the fact that Jesus came into the world to save sinners rather than condemn them (e.g. 1 Tim 1:15, John 3:16-17) are cited as evidence of God's universal salvific will. Jesus is the light that came into the world and enlightens every person (John 1:9). Not all respond positively to this light – it is not irresistible – but every person experiences the illumination of the Logos to one degree or another. Inclusivists maintain that through the power of his resurrection, the light of the world is seeking to draw all people to himself (John 12:32). This same Jesus was successful in drawing to himself those specifically considered outcasts in Jewish society - publicans and sinners (Luke 15). The term sinner in the synoptic Gospels denotes a Jew who willfully refused to follow God's instructions as laid out in the Mosaic covenant. Such people were considered worse than Gentiles by Jewish religious leaders. Luke 15 contains three parables illustrating God's compassion for and willingness to save them. ... If God is indeed not willing that any should perish but wishes all to come to repentance (2 Pet 3:9), and if he does seek the lone lost publican and sinner in this way, is it credible that he would create billions of people without any hope for salvation? The one who prayed, "Father, forgive them; for they do not know what they are doing" (Luk 23:34) would not leave the unevangelized without hope.
The second group of texts
God's dealing with other nations
The second group of texts focuses on God's attitude toward and relationship with the Gentiles outside the covenant with Israel. The OT contains specific declarations that God's benevolent activity is not restricted to the Hebrew people. Deuteronomy mentions several nations for whom God provided land by driving out the previous inhabitants (Deut. 2:5, 9, 19, 21-22; cf. 2 Kings 5:1). The prophet Amos declared that God had performed events similar to the exodus of Israel for other nations (9:7). Inclusivists see in these texts an indication that God did not cut off his gracious activity among the nations just because he elected Israel for a special task. God's salvific will is universal, and that is clearly manifested in the universal covenants of Genesis, which were neither revoked nor replaced by later covenants.
Universal covenants
The first covenant mentioned in the Bible is one made between God and the human race, not God and Israel. God created human beings in his own image and gave them responsibilities (Gen. 1:26-28). After the fall, God promised Eve a "seed" who would provide deliverance from the curse (Gen 3:15). This promise, which is fulfilled in the work of Christ, is destined for the benefit of all people. Noah's sons are considered the fathers of the nations, and the Noachic covenant, which is made with "all flesh" (Gen 9:8-19). When God selected Abraham for a special work, he still had the blessing of "all the families of the earth" in mind (Gen 12:3). We can get a sense of the considerable importance of this universal blessing from the fact that it is mentioned four more times in the book of Genesis (18:8; 22:18; 26:4; 28:14). All the covenants that God made after these were intended not to abrogate but rather to bring to fruition his universal blessing.
Notable individuals
These universal covenants are not the only source of information in the OT concerning God's dealing with the Gentiles. The Bible contains numerous indications that God showed favor to Gentiles and other individuals who lived before the establishment of the covenant with Abraham. Not a few of these individuals occupy prominent place in the biblical narrative – Abel, Enoch, Lot, Job, Balaam, the Queen of Sheba, and Ruth, for example. Of partivular significance are such Gentiles as Melchizedek, Jethro, Rahab, and Naaman. Melchizedek is elevated above Abraham and it is the model of the ideal priesthood. Remarkably, Scripture ascribes the establishment of Israel's judiciary system to Moses' father-in-law, the pagan priest Jethro (Exod 18:17-23). Rahab is singled out as an example of faith for all people to emulate (Heb 11:31), despite the fact that her faith was clearly not theologically well informed.
The case of the Syrian military officer
The case of the Syrian military officer Naaman is quite interesting. The Bible affirms his faith as genuine, despite the fact that he came to it reluctantly. When Elisha told him to rid himself of leprosy, he initially refused, skeptical that such a ritual would bring a resposne from any god (2 Kings 5:11-12). In the end, however, he did as he was told and was healed. In resposne he confessed his faith in the God of Israel and asked forgiveness for when he would have to go into the temple of the god Rimmon in Syria. Elisha gave his blessing upon this. The interesting point here is not only that Naaman came to faith in God reluctantly but that he also labored under a serious theological misconception. Even after his confession of faith he seems to have persisted in a geographical god concept (different gods for different lands), and the fact that he took dirt from the land of Israel back with him to Syria for sacrifical purposes (5:17) seems to suggest a touch of animism in his beliefs as well. Inclusivists view God's acceptance of Naaman despite his errors in belief and his persistence in entering a pgan temple as evidence that God is more inclined to grant salvation to those who exhibit faith than to those who simply adhering to a detailed set of doctrines or liturgical practices.
Other examples from the OT
Elsewhere we learn that God worked through Cyrus the king of Persia and desired Cyrus to acknowledge this fact (Isa. 45:1-7). Daniel expected Nebuchadnezzar to know who the God of heaven was and acknowledge him. In the story of Jonah, and faith of pagan sailors who "feared the Lord greatly" and who "offered a sacrifice to the Lord and made vows" (1:16) is hailed as exemplary, whereas the theologically well-informed faith of Jonah is called into question. God announced through the prophet Amos that though he had chosen Israel for a special work, he did not show favoritism (9:7): his gracious activites were present in other peoples as well. And while it is true that God did sometimes call the Gentile nations to account, the judgments he leveled against them were primarily for moral failures than religious failures as such (Amos. 1:1-2:8; Obad. 15; Nah 1:2; Zech. 9:1). Furthermore, the fact that God did hold them accountable is testimony that they did have genuine knowledge of God and obligations to him even though their religion did not line up exactly with that revealed to Israel.
Examples from the NT
In the NT, we have several examples. Matthew appears to have considered the account of the magi quite important, inasmuch as he devoted a considerable amount of space to it. And he cites them as examples of faith despite the fact that they were pagan astrologers who had a very limited understanding concerning Jesus: they were seeking a king, not a savior. The Gospel of Matthew also notes that Jesus found "great faith" in such unexpected individuals as a Canaanite woman (15:21-28) and a Roman centurion. Regarding the centurion, Jesus said, "truly I say to you, I have not found such great faith with anyone in Israel" (Matt. 8:10). Yet, what was his faith? Did he acknowledge the divinity of Jesus? Did he formulate in his own way the essential beliefs expressed in the Apostles' Creed? No! He simply believed that Jesus had miraculous powers and a benevolent character. Although his understanding was not theologically developed, it was commended for its existential quality.
Cornelius was a God-fearing uncircumcised Gentile who prayed continually. An angel informed him that his prayers and alms were a memorial offering of which God took note (Acts 10:4). It is generally the understanding of the Christian community that Cornelius was a "saved" believer before Peter arrived and that he became a Christian after receiving Christ and being baptized. Cornelius had already subjectively appropriated the merits of Christ's objective redemption through genuine faith in God. He was already worshiping God who saves through Jesus Christ.
God's righteousness
Inclusivists do not claim that people are saved by their righteousness; they contend that people like Cornelius are saved because they have the "habit of faith," which involves penitence. But inclusivists do claim that it is not necessary to understand the work of Christ in order to be saved. G. Campbell Morgan wrote, "no man is to be saved because he understands the doctrine of Atonement. He is saved, not by understanding it, but because he fears God, and works righteousness. Oh, the glad and glorious surprise of those ultimate days when we find that there will be those who walked in the light they had, and wrought righteousness, and were acceptable to Him; not because of their morality, but the infinite merit of the Cross, and by the fact that they yielded themselves to the light they possessed."
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Comments on John Sander's work
Abrahamic attitude
Reading John Sander's biblical examples, what comes clear is that there were people who were not part of Israel or Church, but who were met by God's saving grace. God extended His grace to them even though they did not show a deep theological understanding. We also learn that God had guided other nations and not only Israel, e.g., the prophet Amos declared that God had performed events similar to the exodus of Israel for other nations (9:7). But what comes most clear is that all people from every nation and tribe are influenced by God: "because what may be known of God is manifest in them, for God has shown it to them" (Rom 1:19). On the basis of their response to the divine influence in their hearts, they will be judged accordingly. The pertinent question is, "why would God exert His benevolent influence if not to save them?" He works in human hearts precisely because He wants to save them. There is no point of God to work in people's lives if there were conditions for salvation that were impossible to fulfill. God's benevolent influence that works in the unevangelized represents illuminating light of knowledge that would reveal their moral shortcomings, i.e., their sinful condition, and their need for reconciliation with Him (cf. John 16:8). In other words, the inner divine influence that work in all human beings is God's call on people's lives to acknowledge their sins and their need for Him. God's light that works in all people is the light of an inner understanding of their own insufficiency to attain fellowship with God. This means that every human being has an opportunity to give response to God's call, i.e., an response in accordance to the light of their understanding. Those who positively respond to God's inner call exhibit something that is appropriately called Abrahamic attitude, the kind of attitude that Abraham had when he responded to God's call to leave his city and follow Him. It is the attitude of faith: having trust in God. It is precisely by such faith that we are justified before God.
Just as Abraham "believed God, and it was accounted to him for righteousness." Therefore know that only those who are of faith are sons of Abraham. ... So then they which be of faith are blessed with faithful Abraham. (Gal. 3:6-7, 9)
And the Scripture was fulfilled which says, "Abraham believed God, and it was accounted to him for righteousness." And he was called the friend of God. (James 2:23)
Interesting thing is that Abraham was justified while he was uncircumcised. Abraham became the founding father of Israel by a covenant of circumcision, where circumcision was a sign of belonging to God's people.
[Abraham is] the father of circumcision to those who not only are of the circumcision, but who also walk in the steps of the faith which our father Abraham had while still uncircumcised. (Rom. 4:12)
What kind of faith is in focus here? It is the kind of faith "which our father Abraham had while still uncircumcised." And to whom is Abraham the father? Is he the father of Israelites only? No, but also to all who "walks in the steps of the faith" which Abraham had. People who have this kind of Abrahamic faith exhibit Abrahamic attitude. Inclusivists believe that people from all nations and tribes can have Abrahamic attitude if they respond to God's inner call with trust and commitment, in accordance to the light of knowledge and understanding they have. Why do we call it as Abrahamic attitude? It is appropriately called as such because it is the same kind of attitude Abraham had when he responded to God's call.
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Saving faith
Restrictivism teaches that one must respond positivelly to the Gospel in order to obtain saving faith. An Inclusivist agrees with Restrictivists that saving faith is necessary for salvation, but disagrees that saving faith is obtained only by responding positivelly to the Gospel. Both Inclusivism and Restrictivism affirms that faith is necessary. Having saving faith is to exhibit the kind of attitude that Abraham had, as we have seen in the previous section. An Inclusivist, such as John Sander, would say that faith involves three elements: truth, trust and effective action.
I would say that faith involves three elements: truth, trust and effective action. Genuine faith in God contains some truth about God, whether that truth comes from the Bible or from God's work in creation. Faith means that a person responds in trust to the giver of the truth. If people genuinely trust God, they will seek to live it out in their lives. (John Sander, "Inclusivism" in: What About Those Who Have Never Heard - Three Views on the Destiny of the Unevangelized, p. 37)
Most Christians have no problems with this understanding of faith. Difference do arise, however, over what one has to know in order to have saving faith. What is at issue is the degree of knowledge necessary for having saving faith. Inclusivists maintain that the central problem of salvation is not knowledge of God but faith in God. "Having a right attitude toward God is much more important than doctrinal information" (John Sander, ibid, p. 38). By arguing that believers are saved without knowledge of Christ, inclusivists imply that the unevangelized "may receive a gift without knowing from whom it comes, or how much it has cost" (Strong, Systematic Theology, p. 843).
Children who believe they are receiving gifts from Santa Claus can enjoy them even though ignorant of the true giver. And, just as we hope they grow up to know the real giver, inclusivists express the hope that believers will come to know the source of their salvation - Jesus Christ. It is true that if believers are saved, their understanding of the nature of salvation must nevertheless remain quite limited and their assurance of salvation be virtually nonexistent. But inclusivists contend that assurance and fullness of understanding regarding salvation are not required for salvation. (John Sander, No Other Name, p. 232)
For this reason, Inclusivists maintain the distinction between Believers and Christians. Believers are all who have saving faith (or Abrahamic attitude), but lack the knowledge of Christ and His atoning work. Christians are believers who have the knowledge of Christ and His atoning work.
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Replies to Restrictivist objections
Inclusivism undermines the uniqueness and necessity of Christ (Gospel)
This is not true, since all Inclusivists strongly affirm the particularity and finality of salvation only in Christ (see the definition of Inclusivism together with the definition of terms finality and particularity in the Introduction). The unevangelized who have Abrahamic attitude are saved precisely because of Christ. Christ died for them as well. Those who reject Christ would be condemned indeed. It is unfair of God to condemn people who have never heard about Christ, but have lived according to the light of understanding and knowledge they have received.
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Inclusivism reduces the mandate of the Great Commission
John Sander has several observations concerning missions. First he notes one problematic aspect with Restrictivist view of missions. If Restrictivism is true, salvation is entirely dependent on human preaching. Consequently, some people will suffer eternal damnation due to the failure and disobedience of Christians. In other words, their damnation is the result of the sin of Christians. Is this divine justice? But why should we go to preach to the unevangelized if they can be saved without the knowledge of Christ and His atoning work? John Sander cites several reasons, and here we will mention the important ones:
- We have to be obedient to Christ's command to preach the gospel to all nations (cf. Matt. 28:18-20).
- We wish to share the blessings of Christian life to those who are ignorant.
- Unbelievers need to hear about Christ so that they can know the love of God.
These are more than sufficient reasons for wanting unevangelized to become Christians.
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Alleged proof-texts for Restrictivism
John 3:16-18
For God so loved the world that He gave His only begotten Son, that whoever believes in Him should not perish but have everlasting life. For God did not send His Son into the world to condemn the world, but that the world through Him might be saved. He who believes in Him is not condemned; but he who does not believe is condemned already, because he has not believed in the name of the only begotten Son of God. (John 3:16-18)
It is stated that those who do not believe are condemned; "but he who does not believe is condemned" (v. 18). A Restrictivist understands the statement as saying that a person lacking belief in Christ would be condemned. However, the context makes it clear that "he who does not believe" is an act of rejection of Christ. Anyone who rejects Christ will be condemned. Why should one interpret it as meaning lack of information about Christ, if the whole purpose of Christ is to save mankind, as it is explicitly said in vv. 16-17? If one takes into consideration of how God had benevolent dealing with Gentile nations in the OT times, then He would surely continue such dealing in the NT times as well. Therefore, John 3:16-18 is not a proof-text for Restrictivism.
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John 14:6
Jesus said to him, "I am the way, the truth, and the life. No one comes to the Father except through Me." (John 14:6)
It should be clear why John 14:6 cannot serve as a proof-text for Restrictivism. John 14:6 is a statement of finality and particularity of salvation only in Christ, something all Inclusivists strongly affirm (see the definition of Inclusivism together with the definition of terms finality and particularity in the Introduction). We have also replied to the objection that Inclusivism undermines the uniqueness and necessity of Christ. Jesus is the only way, truth and life, and no body can come to the Father, but through him. Why? Because it is only through His atoning work on the cross that we can receive God's saving grace.
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Rom. 10:13-15
For "whoever calls on the name of the LORD shall be saved." How then shall they call on Him in whom they have not believed? And how shall they believe in Him of whom they have not heard? And how shall they hear without a preacher? And how shall they preach unless they are sent? As it is written: "How beautiful are the feet of those who preach the gospel of peace, Who bring glad tidings of good things!" (Rom. 10:13-15)
Does the passage say anything about the destiny of the unevangelized? No, it does not. The passage does not say that only those who calls upon the name of the Lord shall be saved, but rather assures that any who "calls on the name of the LORD" is saved. Paul the Apostle is saying a simple truism, namely that preaching of Jesus Christ is necessary in order for people to believe in Christ. He does not say anything about the soteriological status of the unevangelized. Therefore, this passage cannot serve as a proof-text for Restrictivism.
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Current Activities• October 13, 2016: This day marks the start of the 250th weekly Disquiet Junto project. • November 16, 2016: I'll be sharing the mic at Adobe Books in San Francisco with my fellow 33 1/3 author Evie Nagy for an evening hosted, from 7pm to 10pm, by Marc Kate (facebook.com). • December 1, 2016: A likely speaking engagement. Details to come. • December 13, 2016: This day marks the 20th anniversary of Disquiet.com. • January 5, 2017: This day marks the 5th anniversary of the Disquiet Junto. • Ongoing: The Disquiet Junto series of weekly communal music projects explore constraints as a springboard for creativity and productivity. There is a new project each Thursday afternoon (California time), and it is due the following Monday at 11:59pm: disquiet.com/junto. • My book on Aphex Twin's landmark 1994 album, Selected Ambient Works Vol. II, published as part of the 33 1/3 series, an imprint of Bloomsbury, is now in its second printing. It can be purchased at amazon.com, among other places.
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Ratings based on 71 Verified Reviews
4.4 Room cleanliness
4.0 Service & staff
4.2 Room comfort
4.3 Hotel condition
Expedia Verified Reviews
by A verified traveler
Great Hotel when in Southern PatagoniaPosted May 24, 2017 on Hotels
Nice, comfortable, and clean hotel in Punta Arenas in Patagonia. Close to restaurants, stores, and car rentals. The staff was very helpful. The hotel is in very good condition and very well maintained. I recommend this hotel when in Southern Patagonia.
by Tommy
Posted Apr 17, 2017 on Hotels
for Couplesby A verified traveler from Los Angeles, CA
Nice Hotel in the Heart of the TownPosted Mar 27, 2017
Pros: Breakfast, location, views, cleanliness
Cons: Laundry was WAY too expensive (I know it's usually a lot through the hotel, but none of the laundromats in town were open on Sunday)
Location: Across the street from Plaza de Armas, walking distance to pretty much everything in town
Location was great, right next to the Plaza de Armas and walking distance to everything we wanted to see. Room was clean and a comfortable size with a great view. Staff was helpful and friendly, not as English-speaking as some of the other tourist hotels we stayed at in Chile, but plenty enough where we had no trouble checking in or ordering dinner. Breakfast was great - tons of options including an omelette bar. We had dinner at the hotel one night and it was very good, and dirnks and appetizers at the bar were also great.
by A verified traveler
NO Transport to the airport.Posted Mar 6, 2017
I had a late flight departing at 2.25am from Punta Arena to Santiago. I specifically looked for a Hotel that provided Airport transfers, booked and paid for the room online. Upon arriving at the hotel, checked in to my room and called reception to arrange for a transfer to the airport. After calling reception three times with no reply I went to the reception to arrange the transfer. I was in formed that the hotel has an arrangement with a taxi company that they would call to arrange a transfer on my behalf but that it was for my own account. The hotel does NOT provide any transport to the airport.
by A verified traveler
Overpriced, nothing special about the room.Posted Feb 26, 2017
Pros: Location
First reservation not honored, sent to another hotel that was below standards. Second reservation honored but way overpriced and nothing special.
by Peter
Comfortable modern hotel in the centre of thingsPosted Feb 5, 2017 on Hotels
The hotel is located on the main square and is convenient for walks to the waterfront and the historic buildings that surround the square. Check in took a while because many people arrived at the same time but the staff were welcoming, helpful and informative.
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Great central location to walk around Punta ArenasPosted Jan 24, 2017 on Hotels
Excellent staff, comfortable dining area. Breakfast offerings are tasty and plentiful. Rooms are fine with some ocean views.
by A verified traveler
Posted Jan 15, 2017
Unhelpful/ inattentive staff. Eat breakfast elsewhere. Nice location. Only a couple parking spots. If they are not available the staff drives your car to an off-site garage.
by Mark
Posted Dec 23, 2016 on Hotels
Nice place, friendly service, good location. The rooms are a little small but big enough.
by A verified traveler
Convenient clean quietPosted Dec 10, 2016 on Hotels
Good location well kept and clean. Free parking is in secure lot 3 blocks from hotel when checking in tell them you want to park and the concierge will take you to the lotZ


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Custom Volunteer Pins
Employee recognition pins and volunteer pins are a very special way to thank very special people. Thanks to volunteers, many conditions around the globe are improving. And we wouldn't even be able to say that without their willpower and hard work. That's why it's important to thank your volunteers with a gift as amazing as they are. Volunteer lapel pins can be custom designed with any image or logo and come in a large variety of metals and enamels. Besides showing gratitude, these pins reward your group or organization and motivate them to keep making amazing impacts on the world. In fact, it's simple to customize pins in a way that represents your volunteer groups' impacts. For example, a favorite image of your group can be printed in detail onto pins. This type of lapel pin is called a printed pin and is just one of many options for customizing these special pins.
Custom volunteer pins can be designed in days!
Another example is making a custom logo pin by etching a logo or a custom image into high quality metal. This still recognizes your group or organization while also illustrating that they have earned more than just the volunteer lapel pin by helping make the world a better place. However, there are many options when it comes to creating one of kind custom logo pins for one of a kind volunteers.
Request a Quote for custom volunteer pins today, or call us at (877) 290-9290 to speak with an expert. We'll help you design a custom recognition pin, service pin, or corporate pin customized to your exact needs.
Volunteer pins are popular among employees and corporate managers alike and serve as a professional, yet decorative way to hold your volunteer in place. Customizable with any design of your choosing, custom volunteer clips are as great to give as gifts as they are to wear yourself.
In today's non-profit environment, custom custom employee pins are an ideal way to create brand awareness, improve your corporate image, and strengthen the morale of your employees.
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Our volunteer pins serve as functional and stylish gifts that your employees will wear with pride.
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Whether you have an existing design for your pins, or if you'd like to have us design your pins for you, Monterey Company has you covered. Simply give us your design, or have one of our top-notch artists help you create the exact artwork you want for free. We can also help you determine the design style that works best for your business at a cost that works for your budget.
Our production staff can use the same kinds of metals that we use for our custom lapel pins along with the classic styles that have made Monterey Company a leader in the field.
Lastly, when you work with Monterey Company, we'll provide you with the design and artwork at no extra charge and offer low minimum quantity.
You see, we excel at giving our valuable customers the finest service, prices, and products in our industry. That's why you'll enjoy only the highest quality volunteer pins for your volunteers.
Would you like more information? One of our friendly customer service representatives are ready to help you discover the perfect custom volunteer pin for your business. Give us a call now, or simply request an online quote with us today!
- Add years of service by engraving the year onto your volunteer pins.
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Our customer service team understand that your time is valuable and will make your experience as simple and efficient as possible. We aim to only ask you questions that are necessary and important. While designing custom logo pins that will provide a gorgeous and unique way to appreciate volunteers, we also specialize in proficient service. You focus on the important work your group or organization does, and we'll focus on designing pins that support that work. And just as everything does when making a change, these custom volunteer lapel pins all start with you.
Non-Profit Organizations Receive 10% off!
Step one is to contact us and we will provide you with a quote for your custom volunteer pins and we will also create a proof of your custom logo pin for your approval! Request a Quote Now.


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Weekly Rewind is a weekly feature where I will recap posts, books read, books bought and borrowed and whatever else from the past week. I've linked to The Sunday Post hosted by Caffeinated Book Reviewer.
This was a week of a lot of phone calls and scheduling appoitnments, going to appointments and running around with the kids. I got through two book for the Make Me Read It Readathon and started o a third, though I won't finish it in time. I still fit in time to binge the current season of Master Chef – I am seriously obsessed with cooking shows right now!! We have been trying out Marley Spoon, one of those meal delivery services, for three weeks and I have enjoyed it. My husband not so much. He hates trying new things. I however like trying new things so he can deal with it. Other than that not much here. Hope you all had a great week!
This week in blog posts
- [7 Aug] Spellbook of the Lost and Found by Moira Fowley-Doyle
- [9 Aug] Most Anticipated Books Coming Out Soonish
- [13 Aug] Weekly Rewind ~ 8.13.17
This week in reading
Boom! Finally a great reading week and I really enjoyed all of these!
Stacking the Shelves
The first two were Audible purchases. Next was the book I picked out because I won the July Contemprary Romance Reading Challenge Giveaway. Last was on sale.


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"Probably the best way to immerse yourself in local Shanghai, in just half a day !"
Bike tour - shanghai
Morning Tour
Our best rated tour !
Hop-on our vintage bicycles and discover the many faces of Shanghai, through narrow lanes of the old town and join locals in their morning routines...
Night Tour
Shanghai by night
What a better way to experience the "City That Never Sleeps" than hopping on one of our vintage Forever bicycles and explore the different areas after dark...
Private Tours
Tailor-made private tours
Book your morning tour OR YOUR NIGHT TOUR now !
The Morning Tour is your best option to discover the real Shanghai & meet the locals
The Night Tour is our latest creation: Ride through Shanghai best spots and feel its energy at night fall!
amazing guides
Cycle safe with our expat Tour Leaders, expert in local life: They are not just great, they speak Mandarin!
Expat Guide
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Fluent in Chinese, your foreign guide will lead you to the the best parts of town, where tourists usually don't go ! Meet his local friends, interact with them, understand what matters most to them and share what will soon become one of your best moments in Shanghai !
Our Routes
Tour design & Experience
Our Tours have been designed following what we love and we think is important to show you. We collect all feedbacks one by one to make sure we are always going in the right direction. All Tours are in English and carefully designed by our product team, re-adapting the itineraries day after day
We have your back!
Your safety is our priority ! Our amazing tour leaders are well aware of that. Our routes are specially design to stay far for cars & others motobikes. We provide free helmets, insurance and safety rules to make sure everyone feels good on the road and focus on what's important.
see OUR availabilitIES
Check our availability on both join-in and private tours
All our Bike Tours are in English (unless otherwise specified)


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We also provided flowers (and grew the wheatgrass) for the bema and dinner on Friday.
At the celebration, we began to reveal the inspiration in the place cards...
...but still tied in the wheatgrass and gerbers.
We did standup cocktail tables, plus clover and lounge seating for the kid's side.


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Currently in my classroom we are reviewing for the end of grade test coming up in 2 weeks. The kids have been working so hard! They have loved working on the 4th grade end of the year review math packet that I made for them and in reading they have really enjoyed having whole group discussions on the different test taking strategies. We will be working more on test taking strategies and talking with the guidance counselor about different strategies to help with test anxiety during the next 2 weeks. Thanks so much for reading and stopping by my blog.
Here are some of my end of the year resources that you may be interested in looking at:


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Wolf Pac Poster
Wolf Pac poster. Working to get money out of politics. Stop the corporate takeover of government.
Justice Democrats
Justice Democrats poster. Democrats that represent people not corporations.
Snake Oil Salesman
Poster design for Snake Oil Salesman a graffiti, street art, urban exploration and train benching website.
Snake Oil Salesman Urbex
Poster graphic created for the graffiti and urban exploring website Snake Oil Salesman.
The Dark Lord
The Dark Lord poster design.
Snake Oil Salesman Website
Snake Oil Salesman graffiti, street art, and urban exploration website.
Wolf Pac Were Coming Poster
Wolf Pac we're coming poster. Get money out of politics.
Save The Girl Sticker
Save The Girl sticker design.
Wolf Pac Is Better Than Your PAC
Wolf Pac is better than your PAC.
Wolf Pac Always Watching
Wolf-Pac is always watching. Get money out of politics.
Wolf Pac Hope Poster
Wolf-Pac get money out of politics. Parody of the Obama hope poster created by street artist Shepard Obey Fairey.
Baphomet In Space
The Baphomet combined with an image taken by the Hubble Space Telescope.


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Folkhalsan Research CentreHelsinki
Folkhalsan Research CentreHelsinki
Baumert J.,Helmholtz Center for Environmental Research |
Huang J.,Lung and Blood Institutes Framingham Heart Study |
Huang J.,U.S. National Institutes of Health |
Huang J.,Wellcome Trust Sanger Institute |
And 129 more authors.
PLoS ONE | Year: 2014
Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-scale meta-analyses of genome-wide interaction studies to identify possible interactions of genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentration. The present study included 80,607 subjects of European ancestry from 22 studies. Genome-wide interaction analyses were performed separately in each study for about 2.6 million single nucleotide polymorphisms (SNPs) across the 22 autosomal chromosomes. For each SNP and risk factor, we performed a linear regression under an additive genetic model including an interaction term between SNP and risk factor. Interaction estimates were meta-analysed using a fixed-effects model. No genome-wide significant interaction with smoking status, alcohol consumption or BMI was observed in the meta-analyses. The most suggestive interaction was found for smoking and rs10519203, located in the LOC123688 region on chromosome 15, with a p value of 6.2×10-8. This large genome-wide interaction study including 80,607 participants found no strong evidence of interaction between genetic variants and smoking status, alcohol consumption or BMI on fibrinogen concentrations. Further studies are needed to yield deeper insight in the interplay between environmental factors and gene variants on the regulation of fibrinogen concentrations. © 2014 Baumert et al.
PubMed | Folkhalsan Research CentreHelsinki and University of Turku
Type: Journal Article | Journal: European journal of endocrinology | Year: 2016
Non-pharmacological interventions are important in reducing risk for osteoporotic fractures. We investigated the effects of a 16-week individualized resistance training intervention on bone mineral density (BMD), bone turnover markers and 10-year relative risk (RR) for osteoporotic fracture.Interventional study with a follow-up.In total, 37 elderly women (mean age 71.9 3.1 years) with decreased muscle strength participated in the resistance training intervention three times per week with 60 min per session for 16 weeks under the supervision of a licensed physiotherapist. Total hip BMD with quantitative CT, bone markers (sclerostin, osteocalcin, CTX, PINP, IGF-1, 25(OH)-D) and 10-year RR for osteoporotic fracture were measured at baseline, post-intervention and at 1-year follow-up after the end of the intervention. Eleven age- and sex-matched controls did not participate in the intervention but were studied at baseline and at 1-year follow-up.Resistance training seemed to increase total hip BMD by 6% (P = 0.005). Sclerostin (P < 0.001) and total osteocalcin (P = 0.04) increased while other bone markers remained unchanged. A 10-year RR for major osteoporotic and hip fracture remained unchanged. At follow-up total hip BMD (P < 0.001) decreased back to the baseline level with a simultaneous decrease in serum sclerostin (P = 0.045), CTX (P < 0.001) and an increase in 25(OH)-D (P < 0.001), 10-year RR for major osteoporotic (P = 0.002) and hip fracture (P = 0.01).Our findings suggest an important role of continuous supervised resistance training for the prevention of osteoporotic fractures in elderly women with decreased muscle strength.