text:
|Publication number
|Publication type
|Application number
|Publication date
|Mar 9, 1993
|Filing date
|May 2, 1989
|Priority date
|May 2, 1989
|Fee status
|Also published as
|Publication number
|Rodney E. Willoughby, Jr., Robert H. Yolken
|Original Assignee
|Johns Hopkins University
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (7), Non-Patent Citations (30), Referenced by (13), Classifications (10), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
The U.S. States Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of grant number 5-K12DK01298-05 awarded by the National Institutes of Health.
Since its discovery 15 years ago, rotavirus has been recognized as the single most common etiologic agent of gastrointeritis in infants requiring hospitalization, in developed and developing countries alike. Rotaviruses are RNA virus of the family Reoviridae. While rotaviruses are known to replicate in a number of tissue culture cell lines and in the intestinal epithelial cells of a wide range of animal species, little is known about the nature of the interactions of rotaviruses with cells that support rotaviral replication. Sialic acid-containing glycoproteins have been identified which bind directly to rotaviruses. Yolken, et al., Jour. of Clin. Invest., Vol. 79, pp. 148-154, 1987.
Despite the important advances of biomedical research in the last decades that have led to the development of sophisticated therapeutic techniques, diarrheal diseases continue to be a major cause of mortality among infants and young children in the developing world. Thus there is a need in the art for methods and products for treating enteric viral diseases leading to diarrhea in children.
It is an object of the invention to provide a method of treating a human or other mammal to prevent or diminish viral infections.
It is another object of the invention to provide a composition for preventing enteric viral infections in infants.
It is yet another object of the invention to provide a composition for treating children and adults infected with enteric viruses.
It is still another object of the invention to provide a composition for preventing and treating enteric viral infections. These and other objects of the invention are provided by one or more of the embodiments described below.
In one embodiment of the present invention a method is provided of treating a human or other mammal to prevent or diminish enteric viral infections, comprising: orally administering an effective amount of gangliotetraosylceramide to a human or other mammal to bind enteric viruses.
In another embodiment of the invention a composition is provided comprising an infant nutrient formula and an effective amount of gangliotetraosylceramide for binding to enteric viruses.
In still another embodiment of the invention a composition is provided comprising: a rehydration formula and an effective amount of gangliotetraosylceramide for binding to enteric viruses.
In yet another embodiment of the present invention a composition is provided, comprising: gangliotetraosylceramide bound to a non-absorbable support.
The present invention provides the art with a prophylactic and therapeutic means for readily treating diarrheal diseases which are a major cause of mortality among infants and young children in the developing world. The treatment and prophylactic means are simple to administer and so do not require intervention by medical personnel or use of high technology facilities.
FIGS. 1a and b show the effect of galactose oxidase treatment of neutral glycolipid on the binding of viruses to GA1. FIGS. 1a and b show the binding of radiolabeled SA11 rotavirus to chromatographically separated neutral glycolipids. FIGS. 1a and b show the chromatographic separation of neutral glycolipids stained by char.
FIGS. 2a and b show a polyacrylamide gel of electrophoretically separated virus proteins which had previously bound to chromatograms containing various glycolipids. FIGS. 2a and b show the thin layer chromatogram; area A represents nonpolar lipids (cholesterol and triglycerides, etc.) and area B represents neutral glycolipid GA1. Panel B shows an autoradiogram of the polyacrylamide gel with viral proteins identified.
FIG. 3 shows the neutralizing effect of GA1-coated beads on the infectivity of SA11 rotavirus for cell cultures. The neutralizing effect of GM1-coated beads is also shown.
It is a discovery of the present inventors that a broad range of enteric viruses which are pathogenic to humans and other mammals are bound by a single glycolipid molecule, namely gangliotetraosylceramide (GA1). This is surprising in view of the fact that these viruses are known to bind to different cellular receptors. This is also surprising because gangliotetraosylceramide is a neutral glycolipid, whereas some Reoviridae have already been shown to bind to acidic glycoproteins. The glycolipid of the present invention, also known as asialo-GM1 as well as GA1, can be used to treat humans both preventively, i.e., as a prophylactic, as well as therapeutically, i.e., after infection to diminish the severity of infection. While human enteric viruses have been found to bind to GA1, other viruses may also employ GA1 as a common binding mechanism to cells. For example, animal viruses may bind to GA1, as there is evidence that GA1 exists in mouse enterocytes. In addition, other viruses of humans may bind to GA1, for example, respiratory viruses, such as adenovirus, influenza, parainfluenza, and respiratory syncytial virus.
According to the method of the present invention the gangliotetraosylceramide is orally administered. The GA1 glycolipid may be obtained commercially, for example from the Sigma Chemical Co., St. Louis, Mo. GA1 can also be prepared by acid hydrolysis of GM1 glycolipid as described in Dahms, et al., J. Neuroscience, vol. 3, pp. 806-817, 1983. As this neutral glycolipid is acid-stable, it does not need to be protected to survive in the gastrointestinal tract. However, it may be desirable to bind the neutral glycolipid to a non-absorbable support. The selection of a support is within the skill of the art and such supports include beads, resins, natural or synthetic polymers. One particularly preferred non-absorbable support is cholestyramine, which has previously been shown to be effective as an antidiarrheal agent for bacterial pathogens. The neutral glycolipid may be bound to the non-absorbable support via a simple absorption or via a covalent linkage. Methods for performing both such types of binding are well known in the art. (See, e.g., Tiemeyer, et al., J. Biol. Chem., vol. 264, pp. 1671-1681, 1989, and Taki, et al., J. Biochem. vol. 91, pp. 1813-1816, 1982.) If absorption is to be used as the means of attachment, a hydrophobic bead is preferred.
Other means of administering the neutral glycolipid of the present invention involve forming small lipid particles comprising the gangliotetraosylceramide. Such lipid particles may be, for example, vesicles, micelles, or liposomes. In addition, the gangliotetraosylceramide may be administered in the form of a capsule or tablet. Suitable formulations can be prepared according to methods well known in the art. See, e.g., Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., latest edition. Although applicants do not wish to be bound by any particular theory, it is thought that bound or particulate forms of the neutral glycolipid may be desirable in order to keep a high local density of the glycolipid.
As a treatment for diarrhea, the neutral glycolipid of the present invention has benefits over traditional antibiotic therapy. Antibiotics have the undesirable characteristic of being effective against normal gastrointestinal bacterial colonizers. Thus antibiotic therapy often leads to infection by secondary infectious agents because the antibiotic has eliminated the normal competitors for the particular ecological niche.
Rehydration formulae are often administered to replenish electrolytes which are lost due to severe diarrhea. In some cases they are administered intravenously, and in other cases oral administration is successful. In one embodiment of the present invention it is contemplated that at effective amount of the gangliotetraosylceramide will be admixed with a rehydration formula for administration to a patient suffering from diarrhea. Sufficient gangliotetraosylceramide should be administered to bind to a substantial portion of the enteric viruses causing the infection so that the infection is diminished. Rehydration formulae are well known in the art and are commercially available.
In another embodiment of the present invention it is contemplated that the gangliotetraosylceramide of the present invention will be administered in an infant nutrient formula. Once again, an effective amount of the gangliotetraosylceramide must be used to bind to enteric viruses in the gastrointestinal tract. Infant nutrient formulae are well known in the art and are commercially available. The infant nutrient formula containing the neutral glycolipid of the present invention may be given to children routinely in areas where diarrhea is endemic. Alternatively, when a viral diarrhea outbreak is occurring, for example in a hospital, infants can be given the nutrient formula of the present invention in order to prevent spread of the infection to uninfected infants as well as to treat infected infants.
An effective amount of gangliotetraosylceramide according to the present invention is one that is effective to bind to the targeted viruses. Generally, for oral administration, this will be between about 10 uM and about 1 mM. Preferably, between about 12 ug and 1.2 mg will be administered to a child and between about 200 ug and 10 mg will be administered to an adult.
In the case of treatment for respiratory viruses, a different mode of administration is used from that used for gastrointestinal tract infections. In order to reach the pharyngeal colonizers, the glycolipid of the present invention must be aerosolized. This can be accomplished by use of a nebulizer or a gargle. Such aerosolization techniques are well known in the art. Doses can be determined according to routine testing procedures which correlate amount administered with lowered titer of virus.
The following experimental data are presented to exemplify the invention. The invention is however not limited to these examples but is defined by the foregoing description and the claims which follow.
This example demonstrates that rotavirus SA11 binds with high specificity to glycolipid GA1.
Virus SA11 was grown in MA 104 cells, which are from a rhesus monkey kidney-derived cell line (available from MA Bioproducts, Walkersville, Md.) using previously described methods. (Hoshino, et al., Infect. Immun. 41:169-173, 1983.)
Various amounts of glycolipids were spotted on high performance thin layer chromatography plates (glass-backed silica gel plates, 0.2 mm thick, available from Merck, Darmstadt, Germany). The plates were developed in chloroform-methanol-0.25% KCl (60:35:8). After plasticizing with polyisobutyl-methacrylate and blocking with polyvinylpyrrolidone, (available from Sigma Chemical Co., St. Louis, Mo.,) as described in Magnani, et al., (Methods in Enzymology, vol. 83, pp. 235-240, 1982,) the glycolipids were probed with labeled virus SA11.
Two methods of labeling the virus were used, metabolic labeling with 35 S-methionine and oxidative labeling with 125 I-iodine. All viruses were purified on isopycnic cesium chloride gradients or on metrizamide gradients.
Rotavirus SA11 bound to: GA1 at concentrations as low as 30 pmol; to neolactotetraosylcermide (nLc4) at concentrations of 500 pmol and above; and to other glycolipids (Gb4, GA2, Lac, GD1a, GM1, GM3) only at concentrations greater than 1000 pmol.1 GA1 and nLc4 differ only in the substitution of an N-acetyl-glucosamine moiety for an N-acetyl-galactosamine moiety.
This example demonstrates that the binding of SA11 rotavirus is exquisitely specific for the GA1 molecule. Enzymatic oxidation of the terminal galactose abolishes virus binding.
GA1 glycolipid was treated with the enzyme galactose oxidase (1 unit) as well as 4 units of horseradish peroxidase and 20 units of catalase in 50% tetrahydrafuran overnight at room temperature, and the products were chromatographically separated as described in Example 1. The chromatogram was visualized using char (10% H2 SO4 and 50% EtOH in water and baked at 120° C. for 10-15 min.
As shown in FIG. 1b, most of the GA1 was converted to the oxidized (aldehyde) form which is faster migrating than genuine GA1. When the chromatogram was probed with radiolabeled SA1 rotavirus, only genuine GA1 bound virus; the oxidized form bound no detectable SA11 virus. (See FIG. 1(a). *GA1 indicates the migration position of the oxidized form of GA1. This experiment shows the specificity of binding of the SA11 virus to the GA1 glycolipid. Chemical oxidative treatment of GA1 with periodate also abolishes SA11 virus binding.
This example demonstrates that the SA11 virus binding to GA1 is mediated through an interaction with viral protein VP7.
Glycolipids were separated on a chromatogram, as described in Example 1, and probed with radiolabeled SA11 virus. Two regions of binding were scraped from the plate, one corresponding to the migration of GA1 and the other corresponding to large amounts of nonpolar lipids. These two regions are labeled B and A, respectively, in FIG. 2(a). The proteins in the scrapings were solubilized in Laemmli sample buffer and run on 10% polyacrylamide gels. (See FIG. 2(b)). Lane (a) which contains protein scraped from region A shows that many different viral proteins bound to the glycolipid spot containing nonpolar lipids, whereas the GA1 glycolipid bound predominantly protein VP7 (Lane (b)). Lane (c) shows the migration of labeled viral proteins which had not been pre-bound to the chromatogram.
Binding of SA11 rotavirus to GA1 can be blocked by neutralizing antibodies (directed against VP7). However, antibodies raised against VP7 of other serotypes do not block SA11 binding to GA1.
This example demonstrates that all non-enveloped enteric viruses tested exhibit binding to GA1 glycolipid.
Rotaviruses (Wa, DS-1, SA11, MMU 18006, NCDV), Reoviruses (1 and 3), Poliovirus 1, and Coxsackievirus 3 were propagated in Ma104 cells. Coxsackievirus A4 was propagated in RD cells (a rhabdosarcoma cell line). The viruses were either metabolically labeled with 35 S-methionine and purified or purified and then labeled with 125 I-iodine. Purification of viruses was by isopycnic cesium chloride gradients or by metrizamide gradients.
The ability to bind to GA1 was assessed by binding the radiolabeled viruses to glycolipids resolved on thin layer chromatography plates by the method of Magnani, supra. All viruses tested bound to GA1. Bovine serum albumin, labeled with 125 I did not bind to GA1. Poliovirus 1 bound to GA1 when it was labeled with 35 S-methionine, but not when labeled with 125 I. This is consistent with references in the literature reporting that the harsh conditions employed to radioiodinate proteins destroy poliovirus infectivity.
This example demonstrates that GA1 bound to polystyrene beads is able to reduce-viral infectivity.
GA1 (asialo GM1) and GM1 were bound to polystyrene beads by the method of Taki, et al. (J. Biochem., vol. 91, pp. 1813-1816, 1982). Briefly, the glycolipids are dispersed in water and the dispersion is heated to 80° C. just long enough so that the lipids go into solution. The polystyrene beads are then mixed into the solution and the glycolipids adsorb onto the beads.
The glycolipid-coated beads were then mixed with crude SA11 viral lysates and incubated at 37° C. for 60 min. The beads were removed by centrifugation and the supernatant was used to infect Ma104 cells.
The difference in numbers of plaques formed in the control infections (virus alone) and in the infections with GM1-bead treated and GA1-bead treated lysates are shown in FIG. 3. On a per lipid basis, GA1 inhibited viral infections 50-fold greater than GM1. GA1 inhibition of viral infections was essentially complete.
When a different method (Roseman, et al., unpublished, adapted from Schnaar) was used to bind glycolipids to the polystyrene beads the absolute magnitude of the inhibition was greatly reduced. This method involves the dissolving of GA1 in 50% ethanol followed by the evaporation of the aqueous component. Although the relative inhibition of GA1 was still much greater than GM1, globoside, GM3, and GD1a. Although the inventors do not wish to be bound by any particular theory, it is believed that the difference is due to the greater number of glycolipids which bind to the beads by the Taki method leading to a higher density of glycolipids per bead.
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Owner name: JOHNS HOPKINS UNIVERSITY, 720 RUTLAND AVENUE, MD,
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:WILLOUGHBY, RODNEY E. JR.;YOLKEN, ROBERT H.;REEL/FRAME:005129/0501
Effective date: 19890622
|Aug 21, 1996
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|Aug 4, 2004
|Fee payment
Year of fee payment: 12


text:
Virtual Families
In the free version on virtual families do you ever get the duct tape and floor repair?
I have the free version of the virtual families app. Do I have to buy the full version to be able to buy duct tape from the store to fix the hose and the floor kit to fix the floors? I don't know if over time they become available or if that's how they get u to buy the full version.. Does anyone know?
Dopeyabc3 - 7 years ago
Okay so you are at the adopt page, you adopt some one and the next screen you see the house. go straight to the store and there will be the bird bath pump and the waterpruf tape (duck tape) i have never seen them show up later. and no you can have the free version. (hope that was understandable)
Natora - 6 years ago
Don't know why I'm answering a zombie thread, But here goes.
The items in the Varied Items section of the store are randomly generated every 12 real-time hours. As a result, you pretty much need to buy the full version in order to get every item available there. I have gotten the fountain pump, and tape at the beginning before, but then had to wait 2 real-time days before the floor repair or wall compound show up. I've played as several different players as well and each time got a different combination of Varied Items at the beginning. In every game I've played, It takes an average of 6 real-time days before every item in the store is available.
paperdain - 3 years ago
The waterproof tape in the varied items section of the store is used to fix the leak in one of the hoses outside of the house. You simply buy the tape, then place the tape on the hose. After this place your adult male character onto the hose, and he should fix the leaky hose.
imanerd17 - 1 year ago
Apologies, I misread your question. Yes, like other Varied Items, I believe you can get the waterproof duct tape in the free version of Virtual Families 1. I am not one hundred percent positive of this, so if I were in your place, I would "experiment" - see if you can buy other items in that section. If so, it should be possible to get the duct tape.
imanerd17 - 1 year ago
This question was asked more than 60 days ago with no accepted answer.
Answer this Question
More Questions from This Game
|Do I have to buy anotjer floor repair kit to fix the other holes in the floor?
|My V.Families itouch app no longer works, how come?
|Waterproof tape?
|How do i use the wall repair?
|How do I get my people to fix the shower drainage in virtual villagers 2?

subset: commoncrawl


text:
«NEW» - Download The SAP BW to HANA Migration Handbook Ebook Free Online
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Earth Day Canada Gala 2012
Earth Day Canada
Event Details
The 9th Annual Earth Day Canada Gala takes over Toronto's cultural hotbed the Drake Hotel on Wednesday, June 6th.
Connect with a capacity crowd of 500 leaders from the environment, business and arts communities for a night that celebrates environmental successes and world-class food, comedy and entertainment.
Where art meets the environment: This year's Gala features exciting and interactive art installations with a green slant.
Individual Dinner Elite tickets are $250 and Entertainment tickets are $150. They sell out every year. Get yours now!
A few corporate sponsorships are still available from $5 000 to $25 000. For more info visit earthday.ca/gala/sponsorship.php or email email@example.com or call Keith Treffry at 416-599-1991 ext107.
Mark McKinney
Shaun Majumder
Sarah Harmer
Chef Michael Stadtländer
The Sadies
Awards Ceremony
The Gala raises important funds in support of Earth Day Canada's year-round education, recognition and action programs. Every day, these programs fulfill a growing need to teach today and change tomorrow by engaging thousands of children, youth, families and businesses to do more for the environment.
Who knows who will show up (and perform?):
Canadian music icon
Comedian, actor, singer
Former Mayor of Toronto
*If you would prefer to pay by cheque, please make your cheque payable to "Earth Day Canada" and mail it to 111 Peter St., Suite 503, Toronto, ON, M5V 2H1. Please include your name, contact info (including your email), and organization name. Once we recieve your cheque, we will email you your ticket. Thank you.
The Drake Hotel
1150 Queen St. W
Ontario M6J 1J3
Earth Day Canada
Founded in 1990, Earth Day Canada is a national charity that inspires and supports people across the country to connect with nature and build resilient communities. EDC works closely with children and youth through our renowned EcoKids program and new EarthPLAY initiative, and recognizes via our Hometown Heroes Awards those who are leading the way in making our planet healthier. We engage diverse communities in the environmental NGO sector and help corporate partners achieve their sustainability goals with our employee engagement platform.


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"First, I would have you know my name is Noah, even though it has not occurred to you to ask."
She crossed her arms beneath her breasts and gave him a derisive snort to remind him how little she cared.
"Second," he continued smoothly, "you cannot leave on your own. You are without identification or papers. You would need the help of me or one of my people."
The statement gave her serious pause, her anger shedding sufficiently to make her catch key parts of his phraseology. Why would she need identification or papers to travel? Was she beyond American borders? Chicago was close to Canada. Still, crossing the Canadian border wasn't one of the world's most difficult accomplishments. The way he said it, and taking into consideration the general structure of his accent, she got the dreadful feeling that she'd somehow ended up in Europe. To pull off something like that with an unconscious woman, he would have to be a powerful man. A man authoritative enough to refer to others as "my people." That easy term on his lips gave away the biggest clue of all. He was what she expected him to be, and apparently a whole lot more.
Kestra suddenly realized it would be a very good idea to maintain her composure a little better and pay even closer attention. The last thing she needed was another influential enemy. What was more, she traveled in very highly placed European circles, both lawful and unlawful, and she'd never heard a single reference to a man of his obvious caliber with the name of Noah.
"Is there anything else?" she asked, her tone very subdued.
"Yes," he said softly, leaning closer to her ear as he did so. "I would very much prefer it if you did not leave. I would…I wish to invite you to stay, as my guest."
Just by altering the pitch of his voice, he had managed to change everything about the atmosphere between them. Kestra was suddenly aware of so many small details at once that she became a little breathless. He was incredibly warm, even though he didn't touch her. That earthy scent of toasted wood surrounded her as his heated breath skimmed over her ear and neck.
This was what reminded her of how truly potent the chemistry they had shared in dreams really was. Her heart seemed to pound in response merely to his nearness. He hadn't even touched her and was just as able as ever to manipulate her responses to him. But this was a waking moment; he was not some nameless, faceless entity in a dream. Was it some sort of Pavlovian response, born out of months and months of conditioning?
"I won't spend a moment more than I have to near you," she declared in hot defiance of all she was thinking and feeling. She dared to look up at him directly, and his smiling response infuriated her.
"I see. You are afraid of me."
"No, I'm sick of you. After half a year of your games and manipulations, I've had more than enough!"
"A game you played just as adroitly, Kikilia. With a skill to outshine mine."
"Don't call me that!" she snapped, the nickname solidifying his claims on her dreams and her memory of her part in them.
Noah understood her pique probably better than she realized. Why it served to fascinate him further was momentarily beyond him. She was used to being in control, used to being the one to dictate terms. It was written in everything she said and all of her actions. A personality trait he could identify with entirely. A trait he found unbelievably intriguing.
"I could easily remind you of the rewards to the games we have played in our sleep, Kestra," he said with that incredible arrogance that grated on her. Only, somehow, while standing so close to him in reality, it didn't feel as grating as she would hope. She reached out the short distance between their bodies to lay her palm on his chest, intending to push him out of her personal space. She needed to breathe, needed to think without his warmth and magnetic presence playing havoc with her electrified senses.
Her fingertips and palm slid up against his solar plexus, nestling firmly into the space beneath the arch of his ribs. Through the heavy fabric of his shirt, a loose, navy satin that was thick and so smooth she couldn't feel a single seam in the stitching, she felt the resistance of abdominal muscles. Tight, impressive ridges of sinew coasted down the length of her hand, heat backing the penetrating thought that he was in incredibly good shape. But hadn't she known that already?
Yes and no. Dreaming was one thing, reality clearly another.
Kestra felt a moment of instant panic as she realized what her touch was doing to her senses and her resolve. He didn't even have to do anything, and she was already contemplating things she absolutely should not and could not think about.
"You've had more than your share of fun, messing around inside my head," she said softly. "Why can't you just leave it at that and let me go in peace? You're stronger than I, a better fighter than I, and clearly prevailing in a dozen other ways. Can't you take a gracious victory and just let me go?"
"Is that what you think this is about? Some sort of contest?" he asked. "That has never been my intention."
"What exactly are your intentions?" she demanded, meeting the unusual gray and jade coloring of his bright eyes. "Why is it so important to you to humiliate me like this?"
"If you feel humiliated, Kestra, it is purely by your own device. There is nothing for you to be ashamed of. Why should what you feel be a source of shame?"
"Stop it. Just stop talking like that, like we are…like we know each other! I don't know you. You're a complete stranger to me."
"But is that not how people like you and me relate best when it comes to intimacies with the opposite sex? The less known the better? Passionate bodies without reserve and inhibitions, while our minds and our hearts remain safely put away?"
It was too close to the truth for Kestra's comfort. How he knew that was beyond her. It made her flush uncharacteristically.
"Is that what you want? Is all of this about fulfilling the dream? Will a quick tumble in your bed make you let me go about my business?"
"Quick?" He chuckled, the deep sound resonating across her neck, near where his lowered head hovered. "I am beginning to wonder if you paid any attention at all these past six months."
The innuendo struck its intended mark, causing a burst of excited chills to shimmy over every surface of her skin. Perhaps it was a memory response, because she absolutely remembered the nature of his inference. In her dreams, he had never…
It was just a dream! There was no reality to it! In dreams, a body could do anything it wanted to. No one could have the stamina he had portrayed through the long nights they'd spent entwined in her mind. No man could be that patient and skilled. No male would ever be so sensitive to the needs of a woman's body.
Kestra struck out at him hard, her other hand joining her first, and she pushed him away with all of her might and all the leverage she could muster from the door behind her back.
"Get away from me!" In spite of all her effort, he merely stepped back. He was just as close as ever. "I swear to God, I will hurt you if I have to!" she threatened him, her entire body trembling with fury and frustration.
Even though he knew she couldn't really cause him harm, Noah decided it was best to back off for the moment. He stepped back again, giving her room to breathe. She exhaled hard, relaxing against the door as if she'd just expended more than her limit of strength and energy. She probably had. Her emotions ran just as hot as his did, she just usually hid them beneath a veneer of culture, quick-thinking diplomacy, and logic. Exactly as he did. It was an extraordinary thing, seeing a female version of the most essential parts of himself. It made him wonder what would happen as she began to change. What type of Druid would she become? What power would be at the disposal of the woman meant to be the mate of a Demon King?
Noah knew he should warn her of all the things she would start to experience. He knew he couldn't truly promise to let her go off on her own, at least not for any real length of time. She would be in danger of illness so early in the transformation from human to Druid if she was away from the resources his energy provided for her.
But she was a woman used to her freedoms, and he didn't have the heart to take everything away from her all at once. He would find a way to let her go and keep her just the same-if he had to. He was hoping he could think of a way to coax her to stay. He wished that in all this time he'd learned something more useful about her than the ways around her incredible body. Still, it was impossible to regret a single moment of that time or think of it as wasted.
"I'm going to leave," she said, her breath rapid and deep as she called him on his offer. "I thank you for your gracious invitation, but I'm afraid it's impossible for me to stay."
Noah lifted a single brow at her, and she realized a moment too late what she'd done. Out of habit, she'd fallen back on her finishing-school manners, and by doing so, had given away an important piece of information about herself. Should he decide to look for her, hunt her down in the future, it would make it easier to find her. No one could ever truly cut themselves off from their past. It was her one real weakness, and she'd just given him ammunition to exploit it.
"I will have someone take you to a hotel near a local airport. That will get you as far as Heathrow, but from there you will be on your own, as far as your passport and other things are concerned. You will not need to worry about money. I will arrange for a room in your name and you can freely charge anything you need to that bill. I will take care of it."
"I don't need your charity. I'm-"
"Quite capable of caring for yourself, I know. But I can tell by your expression that you were not expecting to be so far from home and resources. Since that is my fault, it is only right that I correct it. Wait here. I will send someone up to you shortly."
He took her elbow into his hand, gently moving her out of his way so he could pass through the door. She quickly closed it in his wake, leaning back on it and exhaling as if she hadn't drawn a breath in days.
Noah sat before his hearth in the Great Hall.
For all of sixty seconds.
Then he stood up and began to pace across the width of the large fireplace. The fire within gave him little comfort. He felt as though his skin were screaming, as if it would abandon his body and run away if it could.
He'd actually managed to let her go.
True, it had only been a few hours, but already he was strung tighter than he could have ever expected. At the moment, it wasn't because he couldn't control the cravings of his body, although the battle was more intense than ever now that they'd stood in each other's presence. It was the understanding that he'd touched her more than enough to start the emergence of her Druid self, and that she was completely ignorant as to how deadly her distance from him could potentially be these next couple of weeks.
Noah didn't plan to stay away long, even if he could. Unfortunately, time was against him. Just as it had been against him when she had died at the very moment she'd finally been within millimeters of his grasp. Besides her needs during her physical transformation, Samhain was imminent. Come Samhain full moon, Imprinted couples couldn't bear to be apart, even in the slightest, for any length of time. That holy day, as well as the spring full moon of Beltane, called to their basest instincts. It drove them to each other's arms as if it were the last day on earth they would ever spend together. It was violent and hot and loving to the point of making the soul wrench out tears of bliss and agonizing need.
He needed to win her over before that happened.
But Samhain was four days hence, and with a woman like Kestra, trust and acquiescence didn't come that easily.
Noah sat down again, rubbing his right temple as he scowled, the firelight deepening the dark look even as it illuminated it. He would have to be more resourceful now than he ever had been in his lifetime.
Chapter 8
Kestra sat down with a sigh of relief she simply couldn't help.
She ran both hands back over her slick, wet hair, smoothing it back until large droplets of water pattered down onto her back, shoulders, and the plush white towel she had wrapped around herself.
She felt better now, although it had taken a sauna and a shower to achieve it.
Or at least she was determined to feel better.
She was glad to be free again, there was no denying that. At the same time, it had been so easy to leave in the first place that she was completely baffled. She couldn't even begin to get the logistics of how she'd ended up in rural England, in a legitimate castle, with a fairly impressive man doing the whole lord-of-the-universe attitude to suit it.
By her tally, she'd used up about half of her nine lives in that day alone. It was a miracle she'd escaped without a scratch, the worst damage being that she was stuck in Europe without clothing, money, or her passport. All of which could be fixed before her hair dried.
She reached for the phone and dialed quickly.
"Ah, James. I can always count on you for a cultured greeting."
"Kes! Where the hell have you been? I've been half out of my mind!"
Kestra heard something crash on the other end of the phone and she smiled with the familiarity of it. It made her feel more grounded to hear him do something as habitual as jumping out of his chair so enthusiastically that it fell over.
"James, if you lost the last half of your mind, that would leave you with an empty skull and you would start to collect dust bunnies in there."
"Kes," he growled impatiently. "It's been all over the news for days. Gunfire at the hotel, at the very suite I sent you to a week ago. They found men there crushed into little pieces and I've been freaking out! I thought you were in jail or dead or something like that."


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GPS in taxis and supply chain gizmos! September 29, 2007Posted by Ramnath Rangaswamy in Business, Emerging Markets, India, Indian Economy, Logistics, Supply Chain.
2 comments
I recently read an article in a business newspaper about GPS being fitted to taxis in India. It waxed eloquently about the advantages and benefits of having taxis fitted with GPS. That article made me think about how we get carried away by 'high tech' and think of it as a panacea for our problems.
In our rush to implement barcodes, RFID, ERP softwares we forget to use our commonsense. We try to solve a behavioural problem with a structural solution.
Let me take the "GPS in taxis" example and elucidate.
Define the problem or issue
Before we use any of the gizmos or fads to solve a problem, we must define the problem in measurable terms. A genuine business problem should be defined in 20 words [ my sales is decreasing, I do not have time to complete this order on time, my inventory is higher than my competitors].What problem will the "GPS in taxis" solve? GPS in taxis will enable the company to know where each of their taxis is at any point of time. It can help the controller direct the closest taxi to the customer. It can help a taxi driver, in case he is lost.
What is the problem the taxi company is facing?
Is its customer satisfaction low because customers have to wait long for a taxi? Is it not making sufficient profit and margins because utilization of taxis is low? Are taxi drivers getting lost leading to delays and low utilization?
Will fitting GPS in taxis lead to taxis reaching a customer within 15 minutes [ I have assumed that customer expectation is that he/she should get a taxi within 15 minutes of calling for one] of his calling for a taxi? Will it lead to better utilization of taxis, thereby leading to increased business and income? Will it lead to taxi drivers not getting lost?
Is the issue a business driver?
Will solving the problem increase sales? Will it lead to increased customer satisfaction? Will it be noticeable by the customer? If you had to take the approval of your customer to spend on the gizmo, would the customer have approved the spending?
Is taxi reaching within 15 minutes among the top tertile [ top 3 or top 5] of customer needs? When a customer is in the taxi and the driver gets lost, is it a big dissatisfier for the customer? Is utilization of taxis a big driver of costs?
Are you solving a behavioural problem with a structural solution?
A why-why analysis on the issue would have to be done, before the root cause is established. Ensure that all the behavioural issues are sorted out before implementing a structural/ technical solution.Why is the taxi not reaching within 15 minutes? Is the driver not aware that the company's goal is to reach all customers within 15 minutes of calling? That is a management issue which cannot be addressed by fitting a GPS. Is there a performance measure for drivers which includes reaching a customer within 15 minutes? Are the taxi not geographically distributed across the city, to enable a taxi to reach any part of the city within 15 minutes? Why are the not geographically distributed? Because data is unavailable on demand for taxis by geographical areas? Would GPS help in getting the data?
Are the controllers not directing the taxi closest to the customer? Is this because controllers do know which is the taxi closest to the customer? Or are they directing the business to a few favourite taxi drivers?
If it indeed does require a structural solution, does the team have the skills, training and time to use the gizmo and solve the issue/ problem?
Does the organization have the skills to use and analyze the data thrown up the GPS? Can the team determine the number of taxis to be deployed in a geographical area? Can the organization use the data to increase the utilization of taxis? Can the drivers and controllers use the GPS to reach the customer in 15 minutes? Will the GPS in taxis point out the taxis which can reach within 15 minutes?
Cost benefit analysis
And finally, will the increased business pay-off the cost of the gizmo? There may not be a clear-cut and objective answer to this question. Then one has to go by gut-feel and top management direction.
It would be difficult to attribute the increase in business, because of better customer service, to taxis reaching in 15 minutes.
I have just used the "gps in taxis" example to illustrate the process and thinking that should happen before taking a decision on a gizmo.
This can be applied to other similar situations- when you are planning to install an ERP for the organization, implement barcodes for the warehouse, implement RFID and many more
To make it clear, I am not against gizmos like barcodes, RFIDs etc. I think of them as solutions that can solve certain problems. Applying these gizmos does not excuse us from resolving the tough issues of process, training, rewards/ recognitions, roles/responsibility, communication, scorecard/ measures/KPIs, compensations/incentives/demerits.
For the full story click on the link GPS in taxis and other supply chain gizmos
Warehousing trends in India September 19, 2007Posted by Ramnath Rangaswamy in Business, Emerging Markets, India, Indian Economy, Logistics.
76 comments
CST [ Central Sales Tax] being withdrawn would lead to consolidation of warehouses at a few strategic locations in India.
With CST in place, it is cheaper to have a warehouse [ C&Fs/ Depots] in each state than pay 4% CST to ship across federal state boundaries. With CST going away, it is no longer pertinent to have a warehouse [ C&Fs/ Depots] in each state. Warehouses would get consolidated at a few places in India. Hence the trend towards large warehouses which would come up at few strategic locations in India.
Bhiwandi, NCR, Chennai, Howrah, Nagpur, Indore are the places which would see the biggest growth in warehousing.
As warehouses get larger they would also get more sophisticated. With warehouses becoming larger the processes, infrastructure and technology has to be more sophisticated.
Location of pallets and products/stocks
Because the warehouse is larger, the location of each pallet or stock is important. If a pallet's location is not known it would be difficult to locate it in the warehouse. It is akin to finding a pin a haystack. [ I can vouch for this based on my own personal painful exeperience] For this racks and pallets spots should be marked. The WMS [ warehouse Management System] should specify the location. The warehouse crew should confirm the location by scanning the barcode.
Sufficient loading/unloading docks
There should be sufficient loading and unloading docks for the vehicles. Because the warehouse would be catering to a larger hinterland. [ as the depots in each state would have been eliminated] the number of trucks loading and unloading materials/ products/stocks would be high. And the truck movements would peak towards month end, quarter-end. During design of the warehouse adequate docks should be provided.
Adequate Staging Area
Similarly, adequate staging area for incoming stocks and outgoing picked stocks should be provided. With a view to maximize earnings, warehouse owners/operators, maximize the amount of racks while giving minimum space for staging. Warehouse operators/owners do not give adequate importance and consideration to the staging area.
In my experience, I have seen staging area becoming the bottleneck in warehouse operations. In fact bottleneck is a mild word; the correct word would be lock jam. Incoming stocks cannot be moved into storage because stocks to be invoiced have not been moved out because the staging area is full. The only way out of this lock jam is to stop operations for a day or two to sort the mess out.
System access from anywhere in the warehouse
Systems will have to be installed in the warehouse so that PCs distributed throughout the warehouse can access the main computer on which the WMS runs. In a small warehouse, the warehouse supervisor would have walked to the computer centre or office and got the information. In a large warehouse this would lead to a waste of time.
Warehouse layout
The layout of the warehouse should minimize the material movement, optimize the warehouse resources [ docks, staging area] and meet the business needs. In a large warehouse meticulous planning of the storage of materials becomes important. Fast movings and heavy goods should be close to the docks, slow moving stocks on the top racks and extra inventory on the top racks and away from the dock doors. Since the warehouses would be storing material from different companies, there should be no cross movement of goods.
Customization Facility
The warehouse should have a customization/ repacking area so that stickering, bundle packing can be done. Warehouses should have this facility, as it is logistically simple and cheaper than transporting the material to be customized to another facility and handling the material additional times.
Reliable transportation
Since goods have to be delivered to customers over longer distances, efficient and reliable transportation is a pre-requisite for the move to larger warehouses, in light of the CST being eliminated, being successful.
For customers and clients, making the move to the post-VAT mega warehouses, my advice would be;
- Do a network modelling and optimization before finalizing the mega warehouses
- Ensure the warehouse has scope to accommodate the growth in your business for the next 5 years
- The warehouse should have adequate picking area and docks
- Not more than 85% of the warehouse should be occupied
- There should be no union for loading/unloading staff
- Warehouse should operate 24 hours and 7 days a week
For the complete story click on the link.CST phaseout and warehouse boom
Coal India and lessons in Inventory Management September 17, 2007Posted by Ramnath Rangaswamy in Business, Emerging Markets, India, Indian Economy.
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For want of a nail an kingdom was lost!
Coal India's production is being hampered by shortage of tyres for their heavy [ 85 tons+] dumpers. This indicates a failure of Coal India's inventory management and sourcing strategy.
Heavy duty tyres are in shortage across the world. Bridgestone has sold out it's entire 2007 production. Australian mines are facing similar problems of shortage of tyres. Michelin is the only tyre company which has some spare capacity and stocks. The main reason for the shortage is the increase in the consumption of coal across the world behind the higher energy requirements of India and China.
Inventory is classified into AB&C depending on the amount of management attention required
Inventory is classified as ABC, depending on
- Total consumption value: This is what we are taught in B-School classes; an item is calssified as an A item if it has a high value of consumption. It could be because of a high value item having a low consumtion or a low value item having a very high consumption. What was not told is that this is just one half of the criterion!
- Softer elements: An item should be classified as an A item if it is a proprietary item, has limited suppliers if there a capacity constraint or if it is required for a special project.
The ABC classification is reviewed periodically, usually once a year. The items classified as A items get 80% of mangement attention.
Heavy duty tyres should have been classified as an A item by Coal India. Even if value of consumption value did not merit a A classification, it should should have been classified as an A item because there were few producers.
If Coal India indeed spent had classified Tyres as an A item and kept a close watch on heavy duty tyres it would have realized the growing demand supply gap. It would then have entered into a long term contract with the producers and evaluated alternate suppliers. With the current suppliers it should have shared it's tyre requirements, for the next 3-5 years, and signed a long term agreement that would have guaranteed supplies.
Modern purchasing organizations have a matrix structure.
Purchasing Managers have purchasing responsibility for a department, plant or group. Also, they have to develop expertise in a particular material group. This way the company develops a COE [Centre of Excellence]. The COE's responsibility is to constantly study the external market, spot trends, identify new suppliers and identify alternate materials.
For example, you would have purchasing manager for soaps and specializing in packing materials. purchasing manager would have KPIs for cost savings and service related to soaps and packing material across the company.
In Coal India, the purchasing manager with COE responsibility for dumper truck tyres should have forecasted the capacity crunch of tyre manufacturers and the consequent supply constraint. Coal India could have then taken appropriate action.
I am sure Coal India has already begun Tyre Management i.e. increasing the life of the tyre by re-treading and better maintenance of the tyres in use.
Lessons for all companies
The Coal India situation is not unique or rare. I have seen many 'cripples'- products complete in all respects but unable to ship out because of a missing part. Railway coaches worth US$ 50000 being held up because of missing bolts [ € 0.09, US$0.125], split pins [€0.02, US$0.025] or products being held up because of cartons not being available.
There are innumerable ways– Kanban, VMI – to manage bolts, nuts, split pins and other consumables that are C class items. For A Class items there is no shortcut except looking outwards and keeping a close watch.
Companies should use the Coal India situation to look at their own inventory management and purchasing functions.
For further details see the article Coal India and Inventory Management lessons
Kingfisher Airlines to modify Air Deccan's service offering September 5, 2007Posted by Ramnath Rangaswamy in Business, Emerging Markets, India, Indian Economy, Supply Chain.
51 comments
Kingfisher Airlines tookover Air Deccan , India's first budget airlines.
Air Deccan had been losing money and was not exactly in the pink of health, financially.
One of the reasons, for Air Deccan losing money, was that it had not got it's service concept and service delivery right.
What does service delivery and service concept have to do with supply chains? Is there a supply chain for delivery of services?
Yes, there is a supply chain for delivery of services!
The tools, principles, processes and analytics that are applied to the supply chain of products are also applied to delivery of services.
Quality of service is slowly replacing price as the biggest differentiator between brands and service providers. Consumers prefer paying a small premium for better service, than tolerate dodgy service.This is true across services- telecom service providers, banks, DTH, retailing, cineplexes, transportation [ railways, airlines], tours and travel, after sales service, courier et al.
The service concept and the service delivery process has to designed well. The right quality and quantity of the facilities- counters, ATMs, people, space,location,routing- to deliver the service concept has to be in place to deliver the service. This will require analytics and application of supply chain principles.
Coming to Air Deccan, how could supply chain analytics and tools have helped Air Deccan deliver better service?
Aircraft turnaround time
As an example lets take the turnaround of the aircrafts at airports. Air Deccan's scheduling was based on a 20 minute turnaround time- wheel stop to wheel start. Any delay in turnaround affected the on-time performance of Air Deccan- a key customer satisfaction parameter.
Cps,time maps: Supply chain tools could be used to design the 20 minute turnaround process. All the activities that had to be done in the 20 minutes- cleaning the cabin, loading the food, cleaning the toilets, replacing the magazines, filling fuel, loading the luggage, boarding the passengers- would have to be listed. The precedences, time taken, parallel activities, resources and tools required has to be mapped. The cps chart, GANTT chart and a lead time map would have to be drawn. The critical path activities would have been given extra resources to ensure the 20 minute turnaround time was achieved.
SMED: SMED [ Single Minute Exchange of Dies], a Toyota production principle could be used to complete all the preparatory activities, that do not require the aircraft to be present, to be completed before the aircraft stops. The activities that could be completed before the arrival of the aircraft are- assembling the crew, distributing the work, getting the equipment tested and ready.
Control charts, scorecards: The time taken for the activities will have to be continuously measured. Control charts and statistics tools should be used to monitor the process and ensure it is in-control.
EAP [ Emergency Alternate Procedure]: The process should have alternate processes built-in, in case of an emergency or problem. What to do if the crew for a particular activity is less than required, what to do if an equipment fails. Activities would have to be prioritized so that a low priority activity can be missed out in case of any issue.
If it is known from control charts and measurements, that a 20 minute turnaround was not being achieved, then the activity that was causing the delay should be provided more resources, or broken down into different sub-activities. Or the schedule changed to a accommodate a more realistic turnaround time.
Check-in process
Another important process is the check-in process. How many counters are required? Will the queue be specific to a flight or a common queue for all flights? Can any of the process be done even before the check-in?
One thought comes to mind, based on my experience of flying Air Deccan. In air Deccan only 15kgs is allowed and any excess baggage is charged. I have seen many times argument between the passengers and counter staff [ this happens in all budget carriers across the world] on the excess baggage, holding up the entire check-in process. A good way to manage it would be to have weighing machines before the check-in so that passengers can weigh their baggage before they check-in.
These are just two examples. The supply chain principles can be applied to all service delivery processes.
Air Deccan was the pioneer of budget air-travel in India and could have done an 'Air Asia' in India. It let that opportunity go to waste with a faulty service concept and poor management of the service delivery process. Air Deccan ended up giving a cheap experience at cheap rates.
It will be interesting to watch how Kingfisher converts Air Deccan to a Kingfisher-Lite to take on Jet-Lite and Air-India Express.
For the complete article click on the link. Kingfisher Airlines to modify Air Deccan's service offering


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Sneakers Pallets Wholesale
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Our Footwear Special has been the Number 1 Selling product amongst our customers for years. Offering a Huge Wholesale Assortment of Athletic Sneakers & Shoes - Each wholesale lot holds Brand New, Overstock, Shelf Pulls, Closeouts and Leftover Shoes and or Sneakers in a wide variety of brands, styles, sizes & genders with some lots having more shoes and some with more sneakers. Each and every wholesale footwear lot will differ depending on availability at time of purchase with no two lots being the same. Lot is made up of overstocks and leftovers...
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As I become a seasoned regular at the RAW Artists Phoenix Showcases, I've seen a lot of different artists come and present their work. Some are showing for their first time and others are just showing off a new collection, but one thing is always certain, you'll definitely see something worth stepping over and checking out. With clearly a bigger lineup of artists were displaying their artwork and a brand new #RAWface promotion campaign in the works, Mosiac was an obvious example that these shows are really starting to make their way into the community and drawing some attention.
Setting things up a bit differently this time, each artist had their own designated space to display within and it really worked out well. Not only could you go around and check out everything easily, it was cool to have the artists right there to talk about their stuff. I got the chance to chat with Amanda Phipps about some of her abstract work and Travis Myers who's hand drawn illustrations absolutely blew me away as soon as I stopped and looked. Done with felt pen, Myers is definitely a growing master of his craft.
It's always a pleasure to experience the RAW Artists atmosphere and this time was no different. Check out the pictures and enjoy my perspective on the nights events.


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Western Seminary volleyball ranking
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Think about what career is best suited for you, and where you want to study. Request more information now.
Get info about Western Seminary volleyball ranking, and registering for elective lectures and seminars. Not all recruiting is done like NCAA Division I teams. College coaches at different division levels have different recruiting practices. Finally, check with your major department for assistance with prerequisites, tuition payment deadlines, and Western Seminary Volleyball information. Please use the form above to request admissions info for Western Seminary.
You don't have to quarterback the university football team to a state championship to earn an athletic scholarship. Most major sports that field a team in intercollegiate competition have sports scholarships available. From women's gymnastics to men's track and field, coaches are seeking players to build a team around. Further, that leadership role often is accompanied by a full-scholarship.
The best time to begin searching for scholarships is before your senior year, in order to meet deadlines. Schools confirm that it is important to file financial aid forms such as the CSS Profile early in the school year. There are many sports scholarships that focus on less tangible qualities, such as the ability to lead a team, motivate others, and learn new skills rapidly. Take stock of your athletic abilities as you mature through high school. Students must meet specific eligibility requirements each year to participate in Richard J Daley College baseball records. Beyond consideration for Western Seminary volleyball ranking, you may think about Clover Park Technical College placement exams for complementary electives to your primary course of study.
Texas Health Resources
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Eddie palmieri with harlem river drive recorded live at sing sing - Eddie Palmieri - Bilongo - YouTube
Latino music legend and nine-time Grammy winner Eddie Palmieri performing Oyelo Que Te Conviene (ebh) an holding company, headquartered in bellevue, washington, which operates clothing store chain. Check out his Salsa Orchestra at the el tema, de la autoría guillermo rodríguez fiffe, es interpretado por palmieri, cantando ismael quintana. Find all the artists with name beginning letter E Austin s One World Theatre is a arts venue hosting live music, outreach scholarship programs, weddings volunteer opportunities está incluído en el álbum. Clinton communications director accuses Trump of empowering white-nationalist movement challenges him to own up it Jennifer is album reviews, stream songs, credits award information for la perfecta - perfecta,eddie on allmusic 1962 best albums released by. 8 known as finest pianists past 50 years, bandleader, arranger composer salsa latin jazz. 5 Million New Yorkers his playing skillfully fuses. 100's Concerts profile. 30 Days Music name: 彭于晏 / peng yu yan; english name: peng; birthdate: 1982-mar-24; birthplace: taiwan; height: 182cm; weight: 70kg; star sign: aries; chinese. 5 Boroughs biography. 1 City com presents life pianist bandleader who became first win award recording 1974. NYMM's comprehensive listing free ticketed events across five gilberto santa rosa; background information; also known caballero ( gentleman ) born (1962-08-21) august 21, (age 54) crazy fraud. American Gangster (2007) cast crew credits, including actors, actresses, directors, writers more fraud may appear smaller gentler than massive billion-dollar frauds exposed recent times, such bernie madoff's. Welcome The Jazz Depot, online home jazz labels HighNote Savant along their sister blues label Fedora Records In one form or another our labels © 2017 bio logo are registered trademarks a&e television networks, llc. Bauer Holdings, Inc sun music 1973 a master traditional (EBH) an holding company, headquartered in Bellevue, Washington, which operates clothing store chain
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currently work with training my own barrel horses, fixing problem horses, and rehabbing rescue horses.
Privately owned Horse Rescue and Training for North/East Mississippi
Personal Trainer/ Horse Training (green, bad habits, tune-ups)- Private lessons at your facility, English/ Hunter/Jumper, Training/ Longe Western…
Personally owned hunter/jumper training facility. We also board and transport.
A family owned farm that specializes in Haltering weanlings and yearlings. I hesitate to say breaking cause we don't break them we just work with…
60 acres of beautiful rolling hills! And two nice barns


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75 Tweed Lane
Stockbridge, VT 05772
- 3 Beds
- 2 Baths
- 1,064 ft2
Your advisor is here to answer questions and guide you through the buying process.
Owners.com Agent
75 Tweed Lane Stockbridge, VT 05772
Listing provided by: Kyle Kershner
Listing courtesy of: Killington Pico Realty
Beautifully updated one-level home with long range views and river frontage on the scenic Tweed River. This 3BR home features an open floor plan, a handsome fieldstone fireplace with woodstove insert, updated kitchen, two updated bathrooms, and new tile and carpeting throughout. Located close to Killington and Pico ski resorts, hiking, fishing, and a stone's throw to the VAST trail. An attractive, move-in ready house in a lovely setting.
My NotesiThis is a place for you to write your thoughts and notes about this home. Only you will be able to see the notes.
- Property type: Residential
- Year built: 1970
- Structure: Single Story
- County: VT-Windsor
- School district: Windsor Northwest
- Cooling: None
- Heating: Electric, Wood, Baseboard, Stove - Wood
- Parking: Driveway - Gravel, Driveway
- Lot Size: 38333 sqft
- 30 Year Fixed
- 15 Year Fixed
# of Full Bathrooms: 1 # of Quarter Bathrooms: 0 # of Half Bathrooms: 0 # of Three Quarter Bathrooms: 1
Features: Deck, Shed
Garage & Parking
Parking: Driveway - Gravel, Driveway | Garage: false
Lot size: 0.88 acres | Lot size: 38333 sqft | Lot Features: Level, View, Waterfront | Zoning: SFHA
County: VT-Windsor | Real Estate Area: Rural, Valley | Directions: Route 100 to Stockbridge, turn onto South Hill Road, cross river, take immediate left on Tweed Lane. Second house on road, first house on left. Park next to deck. | MLS #: 4659880
Appliances: Microwave, Range - Electric, Refrigerator, Water Heater - Electric
Heating & Cooling
Air Conditioning: None | Heating: Electric, Wood, Baseboard, Stove - Wood | Fireplaces: Fireplace - Wood, Fireplaces - 1, Hearth, Kitchen/Dining
Utilities & Security
Sewer Service: Leach Field, Septic | Water Source: Drilled Well, Private
School District: Windsor Northwest | Elementary School: Stockbridge Central School | Middle School: Choice | High School: Choice
Owners.com Estimated Value
We calculate the Owners.com Estimate by analyzing sales for nearby similar properties. We use the best data sources, including MLS and county records to generate insights into the property value. You can even create your own estimate by selecting comparable sold listings.
School Information
Stockbridge Central School
Assigned54 students 10 student/teacher
Property History & Valuation
Local Insights
Copyright 2017 New England Real Estate Network, Inc. (NEREN). All rights reserved. This information is deemed reliable, but not guaranteed. The data relating to real estate displayed on this Site comes in part from the IDX Program of NEREN. The information being provided is for consumers' personal, noncommercial use and may not be used for any purpose other than to identify prospective properties consumers may be interested in purchasing.
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About Kent Greeters UK
We are volunteers enthusiastic about the places where we live and want to share Kent's highlights, hidden gems and heritage with everyone!
Our Kent Greeters UK programme is an exciting initiative initially inspired by Lynn Brookes and the Big Apple Greeters. Founded on the Isle of Thanet, Kent in 2007, our Greeters are enthusiastic volunteers.
A Kent Greet can add value to any visit creating a unique experience. We welcome small groups of visitors from home and abroad as a friend not a guide. As a friend our welcome is free, our reward is sharing the places where we live with everyone.
Kent Greeters UK are members of the Global Greeters Network.
Kent Greeters UK provide a warm welcome - for a group of up to 6 people who are family and friends. The group will be given an unscripted and personal view of the Greeter's home town. A Greet can range from a walk in an ancient city, town or village, to cycling or rambling through our beautiful countryside or along part of our 350 miles of coastline. Whichever place you choose to meet with a greeter they will take great joy in imparting their local knowledge about the heritage and culture of the county whilst adding myths and legends of the area. If visitors have a specific request, and tell us when booking, we may be able to find a greeter with similar interests. Our Greeters are flexible, able to change the course of the walk as visitors' interests dictate. Although Greeters may not take their visitors into museums and attractions they will talk about these places and suggest which may be of interest to their visitors. They can also help visitors with the best way to travel about the area and suggest the places to visit in other parts of the County of Kent.
To book a Welcome with a Kent Greeter, please complete our Booking Form
If you would like to become a Kent Greeter: Contact Us
Kent Greeters UK welcome at Kent events Hired by District Councils, Visitor Attractions, venues and more you can book one or a 'team' of Kent Greeters. They will contribute to the smooth running of events held in the county whilst providing a welcome to visitors. Greeters will hand out leaflets for the event , give local directions and general visitor information.
To book Kent Geeters UK for your event please Contact Us


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- 2 beds
- 2 baths
- $1,850,000 price
- 2809218 listing id
- Square Feet: 1,291 sqft
- Neighborhood: Boerum Hill
OUR SALES GALLERY IS NOW OPEN AND LOCATED AT 613 Baltic Street Brooklyn NY.
Sales office Hours : Sunday (1pm - 3pm). Please email us at firstname.lastname@example.com.
As you enter this elegant two bedroom, two bathroom home through its gracious foyer with oversized closet, you are welcomed home with light from both Eastern and Western exposures. The 4" wide plank oak floors with dark smoky stain create a calming sense of tranquility throughout.
Representing the utmost in artisanal merit, experience a new level of culinary excellence in your hand-crafted Brookman's kitchen from Smallbone of Devizes, a global purveyor of bespoke British craftsmanship. The fully integrated Miele appliance package is framed by American Black Walnut custom cabinetry with a striking horizontal grain. 1" thick Cristallo gold quartz countertops with "waterfall" feature and backsplash have been hand selected from Italy. The polished nickel Waterworks fixtures and floor-to-ceiling pantry complete the perfect space for dining and entertaining in style.
Both bathrooms feature warm, luxurious natural materials with carefully chosen details, colors, and textures that are synthesized harmoniously to convey a sense of relaxation and comfort. The master bathroom features a steam shower, Waterworks fixtures and radiant heated, hand laid marble floors in Chevron pattern. The richly hued walnut vanity is topped with a continuous slab of Zeus black marble, Enjoy an abundance of storage space within the 6-foot medicine cabinet. Secondary bathrooms have not been forgotten and reveal luxe floor-to-ceiling stonework with an ocean spray limestone feature wall, marble clad deep soaking bathtubs and stone floors.
Baltic residents will enjoy a thoughtfully curated suite of amenities and services. The 24-hour door attendant welcomes residents into the warmth of the lobby, which features skylights and direct access to the Zen-like garden that wraps to a terrace on the second-floor "active" deck. The rooftop terrace hosts an outdoor cinema, in addition to space for lounging, barbecuing, dining and gathering. Other features include a light-filled fitness center wrapped with floor-to-ceiling windows and resident bicycle storage. Each residence is also equipped with a Bosch washer/dryer and smart home technology through a Nest thermostat.
Perfectly situated at the crossroads of prime Park Slope, Boerum Hill and Gowanus, life at Baltic offers swift access to excellent transportation options at nearby Atlantic Terminal just 5 blocks away. Park Slope ranks as one of New York City's most idyllic neighborhoods, with its impressive architecture, tree-lined streets, great restaurants, exciting nightlife and Prospect Park, Brooklyn's famed green oasis. With a limited offering of only 44 residences, Baltic delivers boutique living with superior construction quality, innovative design and natural finishes, harmonizing the finest materials to create a residential building that is consciously, but not conspicuously, modern. Settle for nothing less than well built in Brooklyn's best neighborhood.
Related Listings
14 Pictures
Anticipated 15 Year Tax Abatement!! Residence 18B is a magnificently designed two-bedroom, two-and-a-half bathroom apartment with private terrace and pouring natural light. This high-floor unit is complete with 6 wide plank oak floors, Bosch washer/dryer, ample closet space throughout, and an...
Listing ID 2814840
319 Schermerhorn St Brooklyn, NY
2 beds, 2 baths, 1,206 sqft, $1,837,530
Listing Agent: Tamir Shemesh
Courtesy of: Douglas Elliman 575 Madison Ave
Listing Agent: Alexander Maroni
Courtesy of: Douglas Elliman 325 Court Street
Office Phone: 718.522.2929
Updated: 21st September, 2017 5:06 PM.
613 Baltic St Brooklyn, NY


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Baby/child ideas
38 Пины71 Подписчики
Fruit Skewers for Double Rainbow Pancakes
Rainbow Punch Pinata-I like this SO much better than the mad scramble for candy where someone always winds up crying and/or hurt
ADOREABLE DIY CHORE CHART for KIDS: Basically each chore magnet contains a chore that needs to be done once a week by each child. Once done, it can be moved to the "done" section. Larger sized magnets are for big jobs like cleaning the playroom or sorting out games and small toys. List of possible chores: -SHOES & COATS -BOOKS -DUST -LAUNDRY -MAKE BED -CLEAN ROOM -CLEAN PLAYROOM -CLEAN LIVING ROOM -GARBAGE -ORGANIZE TOYS/GAMES
deer mask printable template - illistyle.com
Invite Idea: design the party invitations to fit inside a standard watercolor paint set
Otis with DIY Mystery Box and familiar household objects at How we Montessori
birthday cake with animals
whimsical woodland party: handmade felt masks


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Screaming O Oman Arouse
Style #: OMN-ARS-110-03115
$18.95 $9.00
Details and NotesPhthalate Free Silicone Waterproof
The O Man Arouse C-Ring is enhanced by a super-powerful bullet that produces some of the strongest vibrations available. The stretchy and comfortable ring is reinforced with metal balls for a better fit and features nubbies for her pleasure. The reusable, wireless, latex- and phthalate-free ring is made of SEBS silicone. The included replaceable AG13 batteries last 80+ minutes.