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PAUL TRACY (KOOL Honda Reynard), on leading the FedEx Championship Series points race: "It's great to be leading the championship heading to Motegi, but everyone on Team KOOL Green knows that the only time it really counts is after Fontana...
PAUL TRACY (KOOL Honda Reynard), on leading the FedEx Championship Series points race: "It's great to be leading the championship heading to Motegi, but everyone on Team KOOL Green knows that the only time it really counts is after Fontana [season finale]. That's our goal, and we know we're only going to get there by taking it one race at a time. Next up is Motegi, and we're just looking to stay consistent. Our plan is to get a good setup on the car in practice, qualify as best we can and avoid making any mistakes in the race. If we can do that, and good luck continues to smile on us, we'll be there in the end with a chance to rack up some more points. I always enjoy racing in Japan. Twin Ring Motegi is an awesome facility and the Japanese fans are just incredible. They really follow the series and are very nice about asking for autographs and stuff. Motegi will always be a special place for me to race because it was the first place I turned laps in the KOOL car, when we went over there for a demonstration in late '97."
DARIO FRANCHITTI (KOOL Honda Reynard), on turning his season around at Twin Ring Motegi: "I'd like to think we've gotten all of our bad races out of the way for the season and that we can get back on our game at Motegi. With it being Honda's home track and a Firestone-sponsored race, it certainly would be a good time to turn things around. But as bad as things have gone I've got to say I'm really proud of the guys on Team KOOL Green. They've not gotten down and lost their focus or any of their will to win. If anything, they miss the good times that come with winning and are that much more determined to get back on top. Motegi is one of the best racing events in the world in or out of Champ Car racing. The facility is second to none - and I don't just mean the circuit and garages, but the hotel, road course, dirt oval and Honda museum - it's just fantastic. And the fans always amaze you with their knowledge and enthusiasm for the sport. It really makes you feel good to be a part of this series and you want to go out and put on a great race."
BARRY GREEN, Team KOOL Green owner, on the first-class Twin Ring Motegi facility: "You just can't say enough good things about racing at Twin Ring Motegi. Everyone at Team KOOL Green looks forward to the race because the organizers always do a first-class job and the fans are as devoted to Champ Car racing as any in the world. What more could you ask for? Well, I guess a win would be nice for either of our drivers. Paul has got a good season underway and you can't score too many points. For Dario, this would be the place to get that first oval win and start putting some big points on the board this season. And for Team KOOL Green, it would be especially sweet to win the race for our partners at Honda and Firestone."
GIL de FERRAN (Marlboro Honda Reynard), on his past performance at Twin Ring Motegi: "In the two years we've raced in Motegi, I've achieved a reasonable amount of success. Given my record there and most recent form with Marlboro Team Penske, I look forward to another good showing. Our yearly trip to Japan is always a great pleasure because it's Honda's home and a lot of people associated with Honda come out to support us. The Japanese fans are extremely knowledgeable, polite and kind."
HELIO CASTRO-NEVES (Marlboro Honda Reynard), on his memories of racing in Japan: "Japan will always be a special race for me because it's where I scored my first CART points [with an 11th-place finish in 1998] and I had the fastest lap of the race [25.830 seconds] there last year. Marlboro Team Penske has been working really hard and overall, we're pleased with the progress the team has made so far this season. I look forward to racing in Motegi with Honda power this year. I'd love to get my first win there and give Honda its first victory at home."
MICHAEL ANDRETTI (Big Kmart/Texaco/Havoline Ford Lola), on capitalizing on the strength he has shown at Twin Ring Motegi in the past: "I think the Big Kmart/Texaco/ Havoline team will be very competitive in Japan this year. We've done well in the race the last couple of years but have had a lot of bad luck so we feel we are due to win one. We built a big lead on second place in 1998 but I ran out of fuel on my 'in' lap due to a miscalculation. Last year, we were in second place on the last stop and second gear broke which cost us a podium finish at the least. We have had some bad luck in terms of equipment this year but we know the Ford-Lola combination is one of the best and we know the team is capable of winning. We just need everything to come together in Japan and get the ball rolling."
CHRISTIAN FITTIPALDI (Big Kmart/Route 66 Ford Lola), on last year's third-place finish at Japan: "I was surprised when Greg [Moore] spun on the last few laps last year but I was more than happy to move up to a podium finish from fourth place. We were competitive all afternoon in the race, though, so I am confident that we will be competitive again. I didn't run much in the 1998 race because we had an engine problem early on. I learned some good tricks during the race last year and I think we can capitalize on the experience this year. Not only did I learn a lot in the race but I think the team has learned a lot about the Motegi track and I think we can make an even better racecar out of the knowledge. I'm looking forward to running there and putting the Big Kmart/Route 66 car on the podium again."
ALEX TAGLIANI (Player's Forsythe Racing Team Ford Reynard), on the disappointment of being denied his first career Champ Car victory at Rio de Janeiro: "After we were so close in Rio, a lot of people have told me to hang in there and not get discouraged. I appreciate their words of encouragement and, believe me, I'm not down at all. In fact, there were so many positives coming out of the last race that I'm convinced we're closer than ever to getting that first win under our belt. I know that winning the first one is always the toughest, especially when you're a rookie, but everything is clicking with the Player's team. I think the fact we were able to get the pole and lead for most of the race in Rio is a sign that we're right there. We just need to put in that extra effort and maybe get a lucky break to put us over the top. Hopefully, that will be at the Twin Ring in Motegi. I've never raced there but I know the Ford-powered cars like our Champ Car have won both of the races held there thus far."
MEMO GIDLEY (Player's Forsythe Racing Team Ford Reynard), on continuing in his role as a replacement driver for the injured Patrick Carpentier: "I look at the race at Motegi as another opportunity for me to perform to the best of my ability and try to contribute to a win for the Player's team. I wasn't sure how many races I'd have when Player's called on me to fill in for Patrick [Carpentier], but right from the start I was determined to give it everything I've got. I'm pleased with the way things have gone so far. It was nice to get into the points in Rio in my first-ever CART race on an oval track. Being up with the leaders at Rio gives us a big boost of confidence as far as handling the oval circuit at Motegi. When you come in as a replacement driver, you want to be able to contribute so the team can maintain a certain continuity in the driver's absence. With the help of the top-notch Player's crew, I think I've been able to do that. If I've scored a few points with people in the CART series in the process, so much the better."
CRISTIANO da MATTA (Pioneer Toyota Reynard), on continuing the momentum generated by a fourth-place finish in Brazil: "I am really excited to return to Japan for a lot of reasons. We had such a great finish [fourth] in Brazil, matching our best ever. The whole Pioneer team is really pumped up to break that record as soon as possible. I'm looking forward to spending some time with Pioneer and Toyota at their headquarters. It meant a lot to me to be the highest finishing Brazilian in Rio, and I hope to honor Pioneer and Toyota by bringing home another special finish for them in their home country. And finally, because I love the fans in Japan. I can't believe how many fans remember me and the team from last year, so to see them again should be a lot of fun."
LUIZ GARCIA JR. (Hollywood/Embratel/Tang/Banco Sofisa Mercedes Reynard), looking to build on back-to-back points-paying finishes at Long Beach and Rio de Janeiro: "I'm really looking forward to Japan. I had a lot of fun at Motegi last season and it's a track that let's you fly. The first corner is really quick and you have to be careful all the way around. The fans are also fun. In many ways it's a lot like Brazil with the track and fans. They are like my countrymen, very passionate about racing. They are also polite and do their homework because they recognize us at the track. They are very exciting and a little crazy, too. As for the race, we are gaining momentum. Scoring two points in two straight races has been great and I feel we can only go higher with more time in the 2000 Hollywood-Embratel-Reynard car. The Mercedes-Benz engine has been a good one as has the car and Firestone tires. My expectations are higher and very promising. We want to show the fans a great race."


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KICKBOXING FIERCE FIGHT A dynamic cardiovascular workout that utilizes boxing and martial arts style training techniques to improve strength, agility and endurance. This class is a definite cross-trainer to add to your workout. Class is adaptable to all levels.
PIYO Pilates and yoga inspired moves crank up the speed to give you a full-throttle cardio, strength, and flexibility training. Barefoot preferred. P90X LIVE
Get fit fast and have fun doing it! Using the science of muscle confusion, this class constantly challenges your body with new moves and routines. Your results never plateau and you get in better shape in less time.
This low-impact cardio workout is designed with the older adult in mind. You will start out with a warm-up and stretch, an easy-to-follow 20 minute cardio routine, muscle strengthening, and end with a cool down/relaxation. This first Friday of the month will be a Chair Yoga class.
Jump-start your cardio routine with a workout that invites without intimidating. Emphasis is on proper cycling technique while you control the intensity of this world class workout. Arrive 30 minutes before class to pick up your reservation ticket. Doors are opened by Spinning Coach 15 minutes before class so you can set up your bike for a proper fit and safe ride. A towel and water bottle are mandatory for class participation.
STEP AND SCULPT For the "step" lover! This class is designed with variety in mind. Add the "sculpt" and you have a complete workout!
A total body workout split 3 fun ways. Challenge yourself with cardio intervals followed by a strength segment and ending with core training all in 40 minutes utilizing your body weight, free weights, step and so much more!
BOOT CAMP CHALLENGE If you workout downstairs or you're a group fitness fiend you won't want to miss this class. It will be a fun, dynamic and intense circuit workout that incorporates cardio sprints, whole body toning, strength, power, balance and core conditioning. GRIT
This 30-minute class takes cutting edge High Intensity Interval Training and combines it with powerful music and our very own inspirational instructors to give you a workout like no other! Each week the class rotates through Strength, PIYO, and Cardio.
DANCE FITNESS Get a complete cardiovascular workout with this class as you get the benefits of jogging with the fun of dancing. Creatively choreographed for the non-dancer, yet challenging enough for experienced students. The great music almost makes you forget you're working out! LET'S DANCE
This class combines Club, Latin, and Urban music that gets you moving for a fun and efficient hour of cardio! RED HOT DANCE FITNESS
Not your typical workout! This class is dance based that combines the hottest music with easy to follow yet challenging choreography suitable for all levels. This invigorating, calorie-burning dance party will have you addicted from the first beat! ZUMBA
This is an aerobic workout with pulsating Latin music that has an unbelievable affect on everyone who tries it! Incorporates footwork and body movements from flamenco, salsa, meringue and other dances. Come join the FUN and get ZUMBA-FIED! No experience necessary.
ABS & BACK This class is dedicated to strengthening and toning the core muscles. Starts with a short warm-up, followed by a series of continuous abdominal and lower back exercises, ending with a gentle stretch. BARRE ABOVE
Barre Above fuses the very best of pilates, yoga, aerobics, and strength training. No dance experience necessary. Class includes modifications for any fitness level so you can feel successful when achieving an amazing workout! BARRE BURN
A fast and effective way to change your body! This total body workout lifts your seat, tones your thighs, abs and arms AND you'll burn fat. Take this class and hit up a different kind of bar for a change!
BODY PUMP A total body workout that burns calories, shapes, and tones without building bulky muscles. The encouragement, motivation, and great music in every BODYPUMP class will achieve the results you want and deserve! Each class is 55 minutes in length.
CORE & MORE This class strengthens your core and torso muscles plus multiple muscle groups using body weights, gliders, bender ball, bands, ropes, and much more! All fitness levels welcome!
An intense upper and lower body workout with a strong focus on defining the core muscles by challenging both strength and stability. Using a variety of equipment, this class will help you define your body from head to toe. PILATES
This class is a series of core exercises that emphasize the muscles of the abdomen and back. Posture will improve while you lengthen and strengthen all of the muscles in your body.
Using your body weight, hand weights, gliders, and bands, this class utilizes real life functional movement patterns such as twisting, bending, pushing, pulling, lunging and squatting in a FUN and creative way. Core training, balance and flexibility are all included to create a well-rounded program.
This is the gentlest form of yoga. Chair Yoga is easier for those with less limber muscles. Ideal for people with high blood pressure, anxiety, chronic fatigue syndrome, arthritis, vertigo, MS, carpel tunnel syndrome, chronic pain, and for anyone who finds it difficult to get up from or down to the floor. Class is held every Friday. NIA (Neuromuscular Integrative Action) This class is a cardio-dance workout and movement practice that tones your mind and tunes your body. Each workout brings mindfulness to your dance movement, leaving you energized, mentally clear, and emotionally balanced. NIA combines 52 simple moves with dance arts, martial arts, and healing arts to get you fit in body, mind, and spirit. Practiced barefoot, non-impact, and adaptable to all needs and abilities. POWER YOGA
This fast paced yoga class is designed to focus more on strength, breathing and flow. You will be guided through a routine of postures (asanas) that are designed to make the body more fit and supple while at the same time allowing the mind to relax and rejuvenate. Yoga experience helpful.
SPORT YOGA This class incorporates traditional sports stretching, some Pilates mat exercises, and martial arts warm-ups. While Sport Yoga is 70% Hatha style, it focuses more on structure and balance. Beginners welcome!
A dynamic type of yoga with flowing movements connecting yoga postures into one fluid seamless exercise. It is energetic, with emphasis on breath-controlled yoga movements. Level II - Practicing for six months to one year consistently and comfortable with Sun Salutations and various asanas.
A fit and supple body is developed through the practice of postures (asanas). Taken from various Yoga disciplines, the asanas are taught with attention to correct positioning of the body so that each individual part as well as the various physiological systems can function to their best potential. Standing postures and breathing are emphasized in this class. Level II - Practicing for six months to one year consistently and comfortable with poses. YOGALATIES Blending the breath and flexibility training of Yoga with the power and centering techniques of Pilates, Yogalaties offers a workout that stretches and tones the body while relaxing the mind. YOGA THERAPY The ancient art and science of Yoga is used to promote a healthy and well-functioning body and mind. This is a less "athletic" form of yoga and classes will focus on postures that help to manage pain, increase flexibility, and promote health and well-being. Each class will vary but everyone will leave feeling relaxed and replenished.
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The program is designed to help heart patients maintain the best possible cardiovascular health following a heart attack or other cardiac procedures. Y membership and a signed clearance form from your doctor or rehab center is required before starting your maintenance program. Class meets Monday, Wednesday, and Friday from 7:30-11:15 a.m. In-person registration only.
$420/year + membership
Exercise, good nutrition and education can significantly decrease the risk of osteoporosis and prevent further deterioration of the bones in people who already have the disease. Project HEALTHY BONES is an osteoporosis prevention, exercise and education program for older adults. It is designed to improve strength, balance and flexibility using balance an strength training exercises which target the body's larger muscle groups.
Project HEALTHY BONES will also educate you on the importance of exercise nutrition, safety, drug therapy and lifestyle factors as they relate to osteoporosis.
MEDICAL CLEARANCE REQUIRED Healthy Bones Physician Consent And Medical Clearance Form Healthy Bones Participant Release Form
ATTENTION NON-MEMBERS: All Non-Members must sign a photo/hold harmless release in order to participate in programs. Please print, sign and return to Member Services Desk upon or before attending the first class. Photo Release and Hold Harmless
Medical Clearance, Survey and Fall Scale is required. Please print, complete and bring to the first class. One Step Program Medical Clearance One Step Survey One Step Falls Efficacy Scale
All Non-Members must sign a photo/hold harmless release in order to participate in programs. Please print, sign and return to Member Services Desk upon or before attending the first class. Photo Release and Hold Harmless
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So why are the Midlands bucking the trend? What is happening in these areas that is stopping people reaching the levels of distress and despair that leads them to take their lives? These differences are a reminder to us that effective action can be taken at local level to prevent suicide.
Having your period is a regular part of life for half the population, yet you would never know that from how the subject is discussed. It's discussed in whispers, with young girls often taken aside for their education on the matter, as if it is something to be ashamed of. Fortunately, that is beginning to change in Scotland.
It is illegal to assault an adult. It is perfectly legal to assault a child in the name of physical punishment. When you put those two statements s...
We owe a great deal to the performance of our current England and Scotland squads. They are achieving more than our men's teams could muster over two decades. Thursdays match is not just a momentous night for our Lionesses. It's a significant landmark in football.
I have also performed on a cruise for nudists, at a strip club in-between strippers, at a gathering of Hasidic Jews, at a nursing home/hospice, and a little people convention. Then there was that time I cut my arm open with a running chainsaw during a sold out show and had to be rushed to the emergency room. Oh! And also that time I broke both of my feet at the exact same time after jumping down from a 12-foot unicycle.
While Theresa May limps on, her deal throws up an immediate question: will all parts of the UK also receive similar vital additional funding, as Northern Ireland is getting as part of the deal? For me, this is crucial. This massive cash deal with the DUP proves that austerity is a political choice made by the Tories, and when push comes to shove, money can be found. So it is vital that Scotland, Wales and the regions of England also get extra funding to end austerity.
The Conservatives are no longer a toxic brand in Scotland. There lost tribe of socially conservative voters who they lost in 1997 have come back to them. This is a watershed moment in the history of scottish politics when the SNP myth of Scotland as a progressive mecca has been called into question.
But as much as we Londoners like to think that we're at the centre of every significant trend to hit the UK, the truth is that gin production is thriving outside the capital. From south-coast distilleries such as Brighton Gin (distilled in the basement of the Urchin Pub in Hove) to a burgeoning number in Yorkshire, Liverpool and Scotland.
The Tory dismissal of Scotland's right to hold a second referendum on independence in the wake of Brexit has only confirmed that for them Scotland is just another region rather than a partner nation within the UK. Corbyn's support for the denial of this right is not only a U-turn on his previous position on Scotland, but also reveals the same myopic vision of a Union that remains engulfed in a constitutional crisis of Westminster's own making.
As Westminster prepares to go into a long campaign because of Theresa May's U-turn on a snap election, many issues MPs have been working on are in danger of disappearing into the political long grass.
Perhaps Ruth Davidson's Conservatives are that voice - so do not offer any more life support through tactical votes for Labour and instead back Unionism if you oppose the SNP. Then finally we can start on the road to resolving the independence question once and for all.
If Scottish Labour adopt a neutral stance on the upcoming independence referendum and continue to advocate genuine socialist policies, I'm willing to forgive previous misdeeds consider voting them again and I know I'm not alone. If they believe such a position is a betrayal of their values then so be it, but it may end up being the hill they die on.
Nurse Pauline Cafferkey hit the headlines in December 2014 when she became the first person in the UK to be diagnosed with Ebola during the devastatin...
Talking to English friends recently, it has become apparent to me that they don't really think that the United Kingdom is in the process of breaking up as a result of Brexit. It will all blow over, they insist, when everyone realises what a great success Brexit is. Things will unfold like England after the Reformation - sure there were difficult times, some beheadings, a few burnings.
Whilst we in Scotland will celebrate our success and progress, know that we stand with our neighbours in England and will offer our full support until we get the result that is so badly needed. And when we succeed - and we will succeed - we must continue our fight right around the world.
By delivering this treatment on the NHS to those most at risk - and combining it with other vital tools in our HIV prevention armoury, such as condom use, regular testing, and early diagnosis and treatment - this could mark the beginning of the end for HIV transmission in Scotland.


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Modern Day Mr Rogers Neighborhood
In January we signed up for Amazon Prime and I was tickled to find old seasons of Mr Rogers' Neighborhood streaming. I grew up in a PBS household. We watched little television, but what we did was found almost exclusively on PBS. Sesame Street, Reading Rainbow, and Mr Rogers Neighborhood.
(affiliate links are included below)
The last time I watched an episode of Mr Rogers' Neighborhood was probably two decades ago, so I wasn't sure what to expect when I curled up with my sick kids one rainy afternoon.
Two things grabbed my attention.
One, even though television and movies for children today are generally full of bright colors, loud noises, and hectic plots - my kids still loved the simple Fred Rogers version of television. They were literally glued to the screen. They watched in fascination as he rode the elevator. Literally. He was riding the elevator in an office building. Talking about up and down and how the buttons work. They were fascinated.
And two. That's me. I am a modern day version of Mr Rogers. I am not sure entirely how I feel about that or whether I should really be sharing this revelation, but there it is. This is not to say I am him in the sense that I have achieved anything close to his lifetime worth of amazing achievements nor that I have influenced entire generations of children the way he did, but just that somehow I have begun to structure my life and that of my children in a very Mr Rogers Neighborhood type way. The format of his television show is very much the structure of our days. We do simple things like mail a stack of envelopes at the post office, one envelope in the drop box at a time. As I shared in our recent homeschool preschool schedule series;
1. Welcome Chat: We start our days with a conversation. Changing my shoes and sweater have been replaced with muffins and tea. Regardless of what else I'm doing, I'm telling them where we are going to go, who we might see, and introduce any new topics.
2. Take a Trip: Then we go on an adventure of the simplest kind. We visit the post office. We go for a walk to the pond to watch ducks. We go to the doctor's office and learn numbers while we ride the elevator. No joke, that was an activity last week.
3. Make Believe: Then we come home, read some books, take a nap, and then what do we do when we wake up? Pretend. Granted there are rarely puppets involved, but trains, animals and royalty make frequent appearances. Sure I provide a wide array of invitations and learning activities, but inevitably we end up pretending something.
4. Songs: Thrown in for good measure, throughout the day we make up songs. I have made up more ridiculous songs about everything from putting on diapers to waiting your turn than I can remember. Now my kids have begun inventing songs. This past weekend my little fellow came up to me while I was making breakfast and said, "I made up a song about being an Easter bunny, wanna hear it?" Of course I do.
Furthermore, I find myself believing in a very simple approach to education that is full of simple joys, imagination, and curiosity. I believe education should be stopping and watching an earthworm crawl across the sidewalk during a rainstorm or visiting the garden store to pick out plants and seeds together. I want my children to feel comfortable asking questions and wondering about their world. I believe children are capable. Capable of great ideas, of opinions and emotions, of directing their learning, and of learning to care for themselves.
So, maybe I am nuts, but as I watched I noticed more and more similarities. I have to wonder if somewhere in the back of my mind, if these early television experiences, limited that they were, somehow impacted my education practices. This seems unlikely given my 5+ years of Early Childhood Education classes and 11+ years of teaching, but the uncanny resemblance is there. Apparently I need to give in and invest in some puppets because Fred Rogers has certainly had an influence.
I wonder how many teachers and parents were influenced by this same man and his simple, but respectful and ahead of its time approach to education. How many of you are humming tunes, riding elevators for fun, and putting on puppet shows? I am grateful that my children are as delighted as I was, not only by Mr Rogers' Neighborhood, but by the simple joys of childhood. We will continue going on our little adventures, inventing songs, meeting neighbors, and pretending because in my mind, this is what childhood should be.
Want more about Fred Rogers?
Given this discovery, I was curious to learn more about Fred Rogers. Here are some interesting things I learned:
*Fred Rogers was the composer and lyricist of over 200 songs.
*He is the author of numerous books for children, including the First Experience series and the Let's Talk About It series, and the author of many books for adults, including the Mister Rogers Playtime Book, You Are Special, The Giving Box, Mister Rogers Talks with Parents, and Dear Mister Rogers: Does It Ever Rain In Your Neighborhood?. His last book, The Mister Rogers Parenting Book, was praised by Publishers Weekly for the "qualities of warmth and attentiveness that translate very well into this brief yet thorough parenting guide."
*He worked behind the scenes in television for many years, along with appearing on PBS for more than 30 years. In 1968, he was appointed the Chairman of the Forum on Mass Media and Child Development of the White House Conference on Youth and worked tirelessly to improve standards for children's television.
*He was an ordained Presbyterian minister.
*Learn more at: http://www.fredrogers.org/fred-rogers/bio/#sthash.zbuF5YuS.dpuf
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With former manager Billy Davies polarising opinion at The City Ground, the ex-captain and caretaker boss is keen to united those associated with the club when he takes up the role
The former Forest captain has agreed a two-year deal in charge of the Championship outfit that will kick in prior to the 2014-15 season.
The 51-year-old succeeds Billy Davies on a long-term basis, with the Scot having polarised opinion among supporters during his two spells at The City Ground, and Pearce is now keen to unite those at the club.
"I want the club to be at one," he said at his unveiling. "In my time at Nottingham Forest, one of our strongest points was our togetherness."
In returning to Forest - where he was also caretaker manager during the 1996-97 season - Pearce is back in club management for the first time since leaving Manchester City in 2007.
He added: "Coming back to this club is a massive honour for me, but I'm aware what I've achieved as a player is now irrelevant.
"My job is to galvanise a team the fans can be proud of. We want to play a good brand of football."
Under the guidance of caretaker manager Gary Brazil, Forest are one place and two points out of the play-off pack, but are winless since mid-February.
Regardless, Pearce is backing the team to end the season with a flourish.
"I think there is enough quality in this squad to get into the play-offs," he said. There's an opportunity for the team."


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Death Message: A Novel of Suspense (Hardcover)
A Novel of Suspense
Harper, 9780061432750, 464pp.
Publication Date: October 1, 2009
List Price: 25.99*
* Individual store prices may vary.
Not Currently Available for Direct Purchase
Death Message is the unforgettable new entry in the suspense series featuring Tom Thorne, -the next superstar detective- (Lee Child), from Mark Billingham, one of Britain's most compelling and talented crime writers. Billingham, the author of In the Dark and Buried, delivers a chilling thriller that begins with a body and a phone line, both of which are dead.
Coverage from NPR


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And I will be one of those people just this one time.
"However mean your life is, meet it and live it; do not shun it or call it hard names. It is not so bad as you are. It looks poorest when you are richest. The fault-finder will find faults even in paradise. Love your life, poor as it is. You may perhaps have some pleasant, thrilling, glorious hours, even in a poor house."


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|Plein air oil on canvas
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Have a look at my prints, lots to choose from, Beverley views, Beverley Minster, St.Mary's Beverley, Castle Howard etc. Greetings cards. Postcards. Also moving paper models ( automata ) and static models that can be made at home. Click button below for more details.
Wednesday, 27 July 2016
Hidden view of Castle Howard walled garden.
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Procytox 25 mg
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Please feel free to ask our pharmacists any questions about Procytox.
200 tabs for $215.71 ($1.08 per tab)
Procytox from online pharmacy: Canada
Drugs in other countries are sometimes sold using different trade names which will appear on the packaging. This product is sold in other countries as:
- Cyclophosphamide
Save money today when you buy Procytox 25 mg online from The Drug Company. If you have any questions about ordering, call 1-888-254-3038 toll free and speak with a customer service representative. You can also use the Live Chat feature to ensure you find the medication you are looking for. Either way, you can arrange for home delivery of your prescription order, by phone or entirely online. Your doctor will be able to provide you with the prescription you need for Procytox 25 mg.
Bioavailability: The systemic availability, estimated from the ratio of areas under serum-concentration-time curves following oral and intravenous cyclophosphamide (CP), was reported as 97% for a 100 mg, and 74% for a 300 mg dose.
Oral CP is approximately 75% absorbed from the gastrointestinal tract. Oral administration demonstrated 3.5 times more alkylating activity than following an intravenous dose.
In all the pharmacokinetic measurements in man, large inter-individual variations must be considered.
Distribution: A mean apparent volume of distribution of cyclophosphamide was 0.56 L/kg in adults and 0.67 L/kg in children.
Tissue Distribution of CP after i.v. administration to cancer patients indicated that both unchanged parent drug and metabolites in small quantities penetrate the blood brain barrier; brain tissue concentrations being similar to those in blood. Biopsies, performed 2 hours after CP infusion, indicated approximately 30% more radioactivity in lymph nodes compared to muscle, adipose tissue or skin, but relative proportions of unchanged drug metabolites were not established.
Protein Binding: 12 to 14% of unchanged cyclophosphamide is protein-bound; the alkylating metabolites, however, are more extensively bound, namely 67% of the total plasma alkylating activity, and in another study, 39% of phosphamide mustard was protein-bound.
Metabolism: While chemically not reactive, the primary metabolites 4-hydroxycyclophosphamide and aldophosphamide are cytotoxic in vitro, and may represent transport forms of the alkylating moiety, phosphoramide mustard. The two primary metabolites can be further oxidized into the major urinary metabolites 5-ketocyclophosphamide and carboxyphosphamide. Nor-nitrogen mustard, a decomposition product of carboxyphosphamide, is an active alkylating agent with cytotoxicity in vivo and in vitro, however, little antitumor activity could be demonstrated; yet, it may play a role in the hematopoietic and other toxicities of cyclophosphamide. Another metabolite formed from aldophosphamide is acrolein, which has been identified as the most urotoxic species.
Disposition Kinetics: The decline in CP plasma levels following an i.v. dose is biexponential with terminal half-life averaging 7 hours (1.8 to 12.4) for adults, and 4 hours (2.4 to 6.5) for children; daily administration of approximately 50 mg/kg bid or qid (i.v. infusion) to children significantly decreased both plasma half life and urinary excretion of CP. With daily exposure or repeated high-dose administration (i.v.) of cyclophosphamide to adult patients, the half-life of CP decreased without an increase in urinary excretion, suggesting that the drug induces its own metabolism. After an i.v. dose, the NBP [4-(nitrobenzyl)-pyridine] plasma alkylating activity peaks 2 hours after administration, and declines with a half-life of 7.7 hours. Phosphoramide mustard in 3 patients, receiving 60-75 mg/kg cyclophosphamide, peaked 2 to 3 hours after the administration of CP at levels 10 to 20% of the unchanged drug, and declined slowly with levels still detectable at 24 hours.
Even with doses as high as 80 mg/kg, the plasma half-life of CP does not increase.
The t½ and AUC of cyclophosphamide after a 5-day continuous infusion schedule of 300-400 mg/m2/day, were similar to the t½ and AUC of a 1500 mg/m2 i.v. bolus. The AUC of the alkylating activity after 5-day i.v. infusion, however, was three times higher than the AUC of alkylating activity after 1500 mg/m2 i.v. bolus administration of cyclophosphamide. After CP administration to man and laboratory animals, significant differences in the pharmacokinetic parameters of the active metabolite 4-hydroxycyclophosphamide in both man and animals were found. In man, the active metabolite in blood was found at only low but longer lasting concentrations compared to the high and relatively short time concentration in blood of mice and rats, after a comparable dose.
Elimination: In man, a generally higher proportion of the administered CP is excreted as metabolites in urine. Urinary recovery of radioactivity after intravenously administered 14C-cyclophosphamide to patients ranged from 59 to 82% after 4 days, while not more than 20% of i.v. cyclophosphamide was excreted unchanged in urine at any dose level.
Renal clearance estimates of between 5.3 and 11 mL/min indicate substantial renal tubular reabsorption.
Pharmacokinetics in Renal Function Impairment: Patients with severe renal function impairment have a normal biotransformation of cyclophosphamide, but impaired excretion of metabolites with significantly higher plasma alkylating activity. Dose modification of cyclophosphamide, related to the degree of renal dysfunction, may be advised. Patients with moderate to severe renal impairment receiving high doses of cyclophosphamide or those with severe renal impairment receiving conventional doses may require dose reduction, e.g., a dose reduction of 50% for a glomerular filtration rate below 10 mL/minute is recommended.
Cyclophosphamide is dialysable with a high extraction efficiency.
Pharmacokinetics in Hepatic Function Impairment: A patient with Hodgkin's disease showing jaundice, markedly elevated alkaline phosphatase and filling defects on liver scan had the longest cyclophosphamide half life (8.4 hrs) and lowest peak plasma alkylating metabolite level (4.2 µmoles/mL) of 12 patients having received 40 mg/kg CP. Prior hepatic dysfunction and/or hepatotoxic medication might predispose the patient to oral cyclophosphamide toxicity by altering the balance between the enzymatic production of non-toxic metabolites (carboxyphosphamide) and the decomposition of aldophosphamide to the effective alkylating agent phosphoramide mustard.
A. Frequently responsive myeloproliferative and lymphoproliferative disorders:
Malignant lymphomas (see also Dosage):
Hodgkin's disease [Cotswold stages II & III (massive mediastinal disease) and IIIA1,2 - IV E]
Non-Hodgkin's lymphomas (Working Formulation. Low Grade A,B,C; Intermediate Grade D,E,F,G; High Grade H,I,J)
Follicular lymphoma (B,C,D)
Lymphocytic lymphoma (A,B,E; mixed histiocytic, C,F)
Note: Type A, small diffuse and well differentiated malignant lymphocytic lymphoma is consistent with chronic lymphocytic leukemia, to be considered a heterogenous group of chronic B-cell disorders.
Diffuse histiocytic lymphoma (G,H)
Lymphoblastic lymphoma (I)
Burkitt's lymphoma (J)
Multiple myeloma (Myeloma stages II, IIIA, IIIB) (see also Dosage).
Leukemias (see also Dosage):
Chronic lymphocytic leukemia (CLL) (Rai Stages II, III, IV) (Binet Stages B, C)
Note: Chronic lymphocytic leukemias are considered to be a heterogenous group of chronic B-cell disorders.
Chronic Myelogenous Leukemia (CML) (Ineffective in acute blastic crises)
Acute Myelogenous Leukemia (AML) (M0-M7) (Also called acute nonlymphocytic leukemia) Acute Myelomonocytic Leukemia (AMML) (Type M4)
Acute Lymphoblastic (Stem Cell) Leukemia (ALL) in children (Cyclophosphamide given during remission is effective in prolonging remission duration)
Mycosis Fungoides (Advanced disease) (Stages III, IVA, IVB) (see also Dosage).
B. Frequently responsive solid malignancies (see also Dosage):
Neuroblastoma (in patients with disseminated disease, Stage IV)
Carcinoma of the Breast (Stages II-IV)
Retinoblastoma (St. Jude Stages II-IV)
C. Malignant neoplasms of the lung (T N M Staging) (see also Dosage):
Frequently responsive.
Drug Interactions
Cyclophosphamide (<10 mg/kg i.v.) and indomethacin (50 mg p.o. qid). Four (4) cases of severe pulmonary edema and acute life-threatening water intoxication. Appropriate supportive measures should be employed if water intoxication occurs.
Cyclophosphamide (100-150 mg p.o.) and prednisone (20-80 mg p.o.). Four (4) cases of acute respiratory failure; three patients died.
Cyclophosphamide (10 mg/kg infusion) and succinylcholine anesthesia. Post-operative apnea, which is not reduced with smaller doses of cyclophosphamide.
Prior or concurrent treatment with hepatic enzyme inducers such as phenobarbital, phenytoin, benzodiazepines and/or chloral hydrate may induce microsomal metabolism to increase formation of alkylating metabolites of cyclophosphamide, thereby reducing the half-life and increasing the activity of cyclophosphamide.
Cyclophosphamide (15-20 mg/kg 14C) and phenobarbitone (60 mg p.o. tid). Cyclophosphamide half-life decreased from 4.3 hours to 1.6 hours; however, in another study, cyclophosphamide biotransformation was increased 2 to 3 fold after phenobarbitone. In these studies, urinary excretion of metabolites over 48 hours was unchanged.
Alcohol consumption is not recommended in patients treated with cyclophosphamide.
Concurrent cyclophosphamide with allopurinol or hydrochlorothiazide may enhance the bone marrow toxicity of cyclophosphamide. If concurrent use is unavoidable, frequent monitoring for toxic effects is strongly recommended.
Concurrent cyclophosphamide with anthracyclines, (e.g., doxorubicin, daunorubicin, epirubicin, idarubicin) may result in increased cardiotoxicity. It is recommended that the total dose of doxo- or daunorubicin does not exceed 400 mg/m2 of body surface. Specific dosing instructions for idarubicin and epirubicin are not available, and their concurrent use with cyclophosphamide should be undertaken with caution after consulting the relevant product information for each product. Pentostatin or radiation towards the cardiac region may result in increased cardiotoxicity in the presence of cyclophosphamide. Concurrent administration of methotrexate and cyclophosphamide may result in the inhibition of the metabolism of cyclophosphamide.
The blood glucose-lowering effect of sulfonyl ureas may be intensified when administered concomitantly with cyclophosphamide.
Since cyclophosphamide has immunosuppressive effects, the patient can be expected to exhibit a diminished response to any vaccination; injection with activated vaccines may be accompanied by vaccine-induced infection.
Concomitant administration of chloramphenicol leads to a prolonged half-life of cyclophosphamide and to a delayed metabolism.
Concomitant administration of grapefruit or grapefruit juice is not recommended since grapefruit contains a compound that may impair the activation of cyclophosphamide, and thereby its efficacy.
It is prudent to monitor, among others, the following drugs if administered concurrent with cyclophosphamide: Colchicine, Probenecid, Sulfinpyrazone, Cytarabine, Azathioprine, Chlorambucil, Corticosteroids, Glucocorticoid, Cyclosporine, Mercaptopurine, ACE-inhibitors (Pancytopenia is a known ADR of this latter combination), Indomethacin, (see also above EDI-Evaluation of drug interactions-reference).
Concurrent use in cardiac transplant patients of cyclophosphamide with the antihyperlipidemic HMG-CoA reductase inhibitor lovastatin may be associated with an increased risk of rhabdomyolysis and acute renal failure.
While age-related renal and/or hepatic impairment may require cautious dose adjustment, no geriatrics-specific problems are expected to limit the usefulness of cyclophosphamide in the elderly.
Each individual component of a cyclophosphamide-containing poly-chemotherapy regimen must have its precaution profile reviewed.
Since cyclophosphamide is highly toxic with a relatively low therapeutic index, and a therapeutic response is not likely to occur without some evidence of toxicity, the drug must only be used under constant supervision of the attending physician.
Due to potential adverse effects of cyclophosphamide such as nausea and vomiting which may result in vasomotor ataxia, caution should be advised when driving or operating machinery.
50 mg
Each round, deeply biconvex, off-white, sugar-coated tablet contains: 53.5 mg cyclophosphamide monohydrate equivalent to 50 mg anhydrous cyclophosphamide. Nonmedicinal ingredients: calcium carbonate, cellulose, dibasic calcium phosphate, gelatin, glycerin, lactose, magnesium stearate, polyethylene glycol, polysorbate, povidone, silicon dioxide, starch (corn), sucrose, talc, titanium dioxide and wax. Blister packs of 10, boxes 100.
25 mg
Each round, deeply biconvex, white to off-white, sugar-coated tablet contains: 26.7 mg cyclophosphamide monohydrate equivalent to 25 mg anhydrous cyclophosphamide. Nonmedicinal ingredients: calcium carbonate, cellulose, dibasic calcium phosphate, gelatin, glycerin, lactose, magnesium stearate, polyethylene glycol, polysorbate, povidone, silicon dioxide, starch (corn), sucrose, talc, titanium dioxide and wax. Bottles of 200.
Each vial contains: cyclophosphamide 200, 500, 1000 and 2000 mg. No excipients. Single vials. Protect from direct light.
Cyclophosphamide is contraindicated in patients with severely depressed bone marrow function; particularly after previous or during concurrent chemo- and/or radiation therapy without appropriate reduction in dosage.
Caution is indicated, when administering cyclophosphamide to patients with severe leukopenia, thrombocytopenia, and tumor cell infiltration of bone marrow.
Cyclophosphamide is contraindicated in patients who have demonstrated hypersensitivity to this drug or its metabolites, alone or as part of combination chemotherapy.
Because of the mutagenic and teratogenic potential of cyclophosphamide adequate methods of contraception should be used by patients (both female and male) during treatment with cyclophosphamide. The duration of contraception in men and women after the end of chemotherapy depends on the prognosis of the primary disease and on the intensity of the parents' desire for a child. Men should be informed about sperm preservation prior to initiation of treatment with cyclophosphamide. Cyclophosphamide-induced malignancy, mutagenicity, or impairment of fertility must be considered in any risk/benefit assessment.
Use during pregnancy; primarily during the first trimester. If pregnancy occurs during cyclophosphamide treatment, the patient must be informed about the possible risks to the fetus.
Use during breast feeding. Since cyclophosphamide is distributed into breast milk, breast-feeding is not recommended during chemotherapy, due to the potential risks to the infant (adverse effects, carcinogenicity, mutagenicity).
Since varicella-zoster infections appear to be particularly dangerous, concomitant use of cyclophosphamide must be avoided. With all acute infections, caution is indicated when administering cyclophosphamide.
Use in patients with inflammation of the bladder (cystitis).
Use in patients with urinary outflow obstructions.
In combined chemotherapy regimen, the contraindications for each individual drug must be identified.
Extreme caution is recommended in the use of cyclophosphamide for non-neoplastic conditions, because of potential carcinogenicity with long-term use of this agent.
Since cyclophosphamide is an inhibitor of serum cholinesterase, patients receiving this drug may exhibit increased sensitivity to neuromuscular blocking agents, such as succinylcholine. If a patient who is to undergo surgery is receiving cyclophosphamide or has been treated with cyclophosphamide within 10 days of general anesthesia, the anesthetist should be so advised prior to surgery.
The rate of metabolism and the leucopenic activity of cyclophosphamide are increased by chronic administration of phenobarbital.
Cyclophosphamide has been shown to be more toxic in adrenalectomized dogs. Dose adjustments of cyclophosphamide may be necessary for adrenalectomized patients.
Treatment with cyclophosphamide may cause significant suppression of immune responses. Dose modification should be considered for patients who develop bacterial, fungal or viral infections.
Prior to initiating treatment with cyclophosphamide, it is necessary to exclude or correct any obstructions of the efferent urinary tract, cystitis, infections and electrolyte imbalances.
Bladder injury such as hemorrhagic cystitis, or fibrosis of the bladder may develop in patients on long-term cyclophosphamide therapy. Should a cystitis in connection with micro- or macrohematuria appear during treatment with cyclophosphamide, therapy must be interrupted until normalization.
Adverse Effects
Dermatologic Effects
Alopecia occurs commonly in patients treated with even low doses of cyclophosphamide. With large parenteral doses, considerable hair loss (5-30%, with possible total alopecia) is to be expected. The hair can be expected to grow back after or even during continued treatment; it may, however be different in texture and/or colour.
Skin rash occurs occasionally. Pigmentation of skin and changes in nails may occur.
A case of a variant of CHOP-associated erythrodysesthesia syndrome (identified as a variant of palmar-plantar erythema) related to high-dose cyclophosphamide has been reported.
Cardiotoxicity, which is uncommon at usual cyclophosphamide dosages, has been reported at high doses of between 120 and 180 mg/kg to as high as 270 mg/kg within a period of 4 to 6 days. This dosage range is usually part of an intensive polychemotherapy regimen, or is given in conjunction with transplantation procedures. This secondary cardiomyopathy may manifest as arrhythmias, ECG changes and/or LVEF (e.g., myocardial infarction). Cases of severe and sometimes fatal congestive heart failure have occurred within a few days after the first dose of a high-dose course of cyclophosphamide. Histopathologic examination revealed primarily hemorrhagic myocarditis. A fatal high-dose cyclophosphamide-induced cardiomyopathy, characterized by hemorrhagic myocardial necrosis has been reported.
There is evidence that the cardiotoxic effect of cyclophosphamide may be enhanced in patients who have received previous radiation treatment of the heart region and/or adjuvant treatment with anthracyclines or pentostatin. In this context, regular electrolyte monitoring is necessary and special caution is advised in patients with pre-existing heart disease.
Sudden weight gain, ECG abnormalities, dyspnea and/or other signs of congestive heart failure should be monitored. The antidiuretic effect, occasionally seen with cyclophosphamide alone, and as drug interaction with indomethacin (the latter manifesting itself as severe water intoxication-SIADH), may contribute to the cardiopulmonary pathology.
Pulmonary toxicity due to cyclophosphamide is a recognized entity. Interstitial pulmonary fibrosis, which can be fatal, has been reported with long-term high-dose cyclophosphamide. Careful monitoring is advised, since in some cases the discontinuance of the drug and administration of corticosteroids have failed to reverse this syndrome. In isolated cases, pneumonitis may develop.
Nausea and vomiting are common with cyclophosphamide treatment and are dose-dependent. Moderate to severe forms occur in approximately 50% of patients. Anorexia and, less frequently, abdominal discomfort or pain, diarrhea or obstipation, constipation and inflammatory conditions of the mucosa (mucositis), ranging from stomatitis to ulcerations may occur. There have been isolated reports of hemorrhagic colitis, oral mucosal ulceration (stomatitis), and jaundice occurring during therapy. These adverse events generally remit when cyclophosphamide is stopped.
Hematopoietic System
Depending on the dose of cyclophosphamide administered, different degrees of myelosuppression may occur, involving leukocytopenia, thrombocytopenia, hypothrombinemia, and anaemia. It can commonly be expected that leukocytopenia with and without fever and the risk of secondary (sometimes life-threatening) infections will occur, as will thrombocytopenia associated with the higher risk of a bleeding event. The leukocyte and platelet nadirs are usually reached in week 1 and 2 of treatment. They usually recover within 3 to 4 weeks after the initiation of treatment. Anaemia will usually not develop until after several treatment cycles. Pancytopenia is a known ADR of cyclophosphamide in combination with, for instance, etoposide and cisplatin, where individual drug cause is difficult to identify. More severe myelosuppression is to be expected in patients who have been pre-treated with chemo- and/or radiotherapy and in patients with renal impairment. A combination treatment with other myelopsuppressive agents may require dose adjustments.
Leukopenia of less than 2000 cells/mm3 develops commonly in patients treated with an initial loading dose of the drug.
Thrombocytopenia nadirs occur within 10-15 days after administration.
The degree of neutropenia is particularly important because it correlates with a reduction in resistance to infection.
Thrombocytopenia, hypothrombinemia, and anemia occasionally develops in patients treated with cyclophosphamide. These toxic effects can usually be reversed by reducing the drug dose or through interruption of treatment.
Other Adverse Effects
Nadir fever, headache, dizziness, diabetes mellitus, blurring of vision and myopia. Rare cases of rhabdomyolysis have been reported. Acute pancreatitis may occur in isolated cases. In rare cases, severe skin reactions like Stevens Johnson Syndrome and toxic epidermal necrolysis have been reported under cyclophosphamide therapy. Cyclophosphamide may impair wound healing, which can be alleviated by supplemental vitamin "A"; monitoring the patient is necessary, to prevent a possible drug interaction.
There are certain complications, such as thromboembolism, DIC (disseminated intravascular coagulation), or hemolytic uremic syndrome (HUS), that may also be induced by the underlying disease, but that might occur with an increased frequency under chemotherapy that includes cyclophosphamide.
Carcinogenesis: As with cytotoxic therapy in general, treatment with cyclophosphamide involves the risk of secondary tumours and their precursors as late sequelae. The risk of developing urinary tract cancer as well as myelodysplastic alterations partly progressing to acute leukemias, or non-malignant disease in which immune processes are believed to be involved pathologically is increased. Urinary bladder malignancies have usually occurred in patients who previously had hemorrhagic cystitis. Animal studies demonstrate that the risk of bladder cancer can be markedly reduced by an adequate administration of mesna.
There have been isolated reports of hemorrhagic cystitis resulting in death.
Sterile hemorrhagic cystitis, which can become a severe to fatal condition, mainly due to long-term daily low-dose, or short-term high-dose cyclophosphamide, is thought to be secondary to the formation/concentration of the toxic metabolite acrolein during prolonged contact with the bladder epithelium. Changes in the efferent urinary tract may also occur. Hemorrhagic cystitis, microhematuria and macrohematuria are the most common dose-dependent complications of treatment with cyclophosphamide. Cystitis is initially abacterial; secondary bacterial colonization may follow. Reduction or interruption of cyclophosphamide, forced diuresis, hydration may limit the time of contact between the metabolite acrolein and the bladder epithelium. Prophylactic Mesna treatment is effective in many patients. Hematuria usually resolves spontaneously within a few days after interruption of cyclophosphamide therapy, but may persist for several months.
Cyclophosphamide-related non-hemorrhagic cystitis, edema of the bladder wall, suburethral bleeding, interstitial inflammation, and at times extensive fibrosis of the bladder with atypical cells in the urinary sediment have also been reported. A potential for sclerosis of the bladder wall also exists. Cryosurgery and other methods have been used in protracted cases.
Renal lesions (particularly in patients with a history of impaired renal function) are a rare side effect after high doses of cyclophosphamide. Interruption of therapy may, in most cases, resolve the lesion.
Second malignancy of the urinary bladder may develop, generally in patients who previously developed hemorrhagic cystitis, and may in some cases not be detected until several years after discontinuance of cyclophosphamide. Studies in animals have demonstrated that the risk of bladder cancer can be markedly reduced by an adequate administration of Mesna treatment.
Sterility in both sexes may result from cyclophosphamide treatment, depending on dose, duration of therapy, and state of gonadal function at time of treatment. By virtue of its alkylating mode of action, cyclophosphamide can be assumed to cause partially irreversible disturbances of spermatogenesis and the resulting azoospermia or persistent oligospermia. Ovulation disorders, that sometimes take an irreversible course, with the resulting amenorrhoea and lower levels of female sex hormones occur with a rarer frequency. Ovarian atrophy, fibrosis and complete absence of follicular structures are reported histologic features in some cyclophosphamide-treated women, where regaining reproductive function is unpredictable.
Metabolic Effects
As a result of rapid cellular destruction (tumor lysis), especially in non-Hodgkin's lymphomas or leukemias, hyperuricemia may occur in some patients being treated with cyclophosphamide. Hyperuricemia may be minimized by adequate hydration, alkalinization of the urine, and/or administration of allopurinol. If allopurinol is decided upon, the patient must carefully be monitored to prevent severe cyclophosphamide toxicity (see Precautions, Drug Interactions). Cyclophosphamide-related hyperkalemia may also be due to tumorlysis.
A syndrome of inappropriate antidiuretic hormone secretion (SIADH) with hyponatremia and water retention has occurred in patients on high-dose cyclophosphamide therapy. Careful monitoring of this condition is advised.
Rare cases of disturbances of hepatic function have been reported that are reflected by an increase in the corresponding laboratory test values (AST, ALT, gamma-GT, alkaline phosphatase and/or bilirubin).
Veno-occlusive disease (VOD) is observed in approximately 15-50 % of the patients receiving high-dose cyclophosphamide in combination with busulfan or whole-body irradiation during allogenic bone marrow transplantation. By contrast, VOD is only rarely observed in patients with aplastic anaemia who are receiving high dose cyclophosphamide alone. The syndrome typically develops 1-3 weeks after the transplantation and is characterized by sudden weight gain, hepatomegaly, ascites and hyperbilirubinaemia. Hepatic encephalopathy may also develop. Known risk factors predisposing a patient to the development of VOD are pre-existing disturbances of hepatic function, hepatotoxic drug therapy concurrently with high-dose (chemo)therapy and especially when the alkylating agent busulfan is an element of the conditioning therapy.
Limited information on acute overdosage of cyclophosphamide is available.
Since no specific antidote for cyclophosphamide is known, great caution is advised each time it is used. If overdose of cyclophosphamide is known or suspected, the patient should be hospitalized for general supportive therapy. Cyclophosphamide can be dialysed. Therefore, rapid hemodialysis is indicated when treating any suicidal or accidental overdose or intoxication. A dialysis clearance of 78 mL/min was calculated from the concentration of non-metabolized cyclophosphamide in the dialysate (normal renal clearance is around 5 - 11 mL/min). A second working group reported a value of 194 mL/min. After 6 hours of dialysis, 72% of the dose of cyclophosphamide administered was found in the dialysate. In the case of overdose, myelosuppression, mostly leukocytopenia, is to be expected, among other reactions. The severity and duration of the myelosuppression depends on the extent of the overdose. Frequent checks of the blood count and monitoring of the patient are necessary. If neutropenia develops, infection prophylaxis must be given and infections must be treated adequately with antibiotics. If thrombocytopenia develops, thrombocyte replacement should be ensured according to need. It is essential that cystitis prophylaxis with mesna be undertaken to avoid any urotoxic effects.
Cardiotoxicity may also occur with overdosage. In patients who received 4 to 10-day courses of cyclophosphamide with total dosage per course exceeding 140 mg/kg or 5.2 g/m2, cardiac damage manifested by heart failure occurred within 15 days of the initial dose. Impairment of water excretion with hyponatremia, weight gain, and inappropriately concentrated urine has been reported after cyclophosphamide doses exceeding 50 mg/kg (2 g/m2).
At least one fatal case of cyclophosphamide overdosage had been reported; potentially fatal cardiotoxicity was the most serious consequence of overdosage. The risk of overdose with high-dose cyclophosphamide concomitantly with radiation therapy or other potentially cardiotoxic drugs (e.g: anthracyclines) must carefully be taken into consideration.
If a cyclophosphamide solution is inadvertently administered by paravenous injection, there is usually no danger of cytostatic tissue damage since such damage is not expected before cyclophosphamide has been bioactivated in the liver. Nevertheless, if paravasation should occur, stop the infusion immediately and aspirate the paravasate with the cannula in place, irrigate the area with saline solution and immobilize the extremity.
See Symptoms.
Cyclophosphamide is a drug with the potential for fatal complications, and should, therefore, be only used by a physician experienced with cancer chemotherapeutic drugs and/or immunosuppressive therapy.
Parenteral products prior to administration need to be visually inspected for discolouration and particulate matter. After reconstitution, this parenteral dosage form represents a colourless and clear solution.
During or immediately after the administration of cyclophosphamide, adequate amounts of fluid should be ingested and the patient should empty his/her bladder at regular intervals. Prophylactic treatment with Mesna is recommended for protection of the bladder (see Warnings; Precautions, Information to Be Provided to the Patient; and Adverse Effects).
Initial Loading Dose: Cyclophosphamide: Patients with normal hematologic and bone marrow function: Adults: i.v. 40-50 mg/kg (1.5-1.8 g/m2) as 10 to 20 mg/kg/day for 2-5 days. Children: i.v. 2 - 8 mg/kg (60-250 mg/m2) in divided doses for six or more days.
Patients with compromised bone marrow function due to prior radiation therapy, poly-chemotherapy, or tumour cell infiltration, must have their initial loading dose reduced by 30-50%. Dosage adjustment must also be considered for children and adults with concurrent disease or special conditions. Adults: p.o. 1-5 mg/kg/day depending upon the tolerance of the patient. Children: p.o. 2-8 mg/kg (60-250 mg/m2) in divided doses for six or more days. Morning administration of cyclophosphamide is recommended.
The leukocyte count generally serves as a guide to dosage adjustments, and maintaining a range of 2500-4000 cells/mm3 is recommended to possibly avoid infection.
The above initial loading doses may lead to transient or more persistent reduction to 200 cells/mm3. The patient's hematologic profile must carefully be monitored.
Maintenance Dose: Cyclophosphamide: It is generally advisable to administer the largest maintenance dose that can reasonably be tolerated by the patient, unless the disease is unusually sensitive to cyclophosphamide. Adults: i.v. 10-15 mg/kg (350-550 mg/m2) every 7-10 days; i.v. 3- 5 mg/kg (110-185 mg/m2) twice weekly; p.o. 1- 5 mg/kg/day. Children: i.v. 10-15 mg/kg every 7-10 days, or 30 mg/kg at three- to four-week intervals or when bone marrow recovery occurs. p.o. 2- 5 mg/kg (50-150 mg/m2) twice weekly. Concurrent disease, special conditions including performance index must lead to dosage adjustment.
Polychemotherapy Regimen: As with monotherapy, it is advisable that treatment-related emergency measures and equipment, including pathology-specific antibiotics be physically present during polychemotherapy.
It should be noted that regular and high-dose cyclophosphamide as monotherapy or as component of polychemotherapy are being effectively used in patients resistant to first line treatment such as melphalan or busulfan. Objective responses in a variety of different forms of cancer, plus its relative platelet-sparing effect make cyclophosphamide an alternate drug of choice. Cyclophosphamide as 60 mg/kg i.v. for 2 days may be administered for bone marrow transplant conditioning. In patients with multiple transfusions, cyclophosphamide is not adequately immunosuppressive, requiring the addition of AT to the retransplant cytoreduction conditioning.
Note: Due to constant new developments in cancer chemotherapy, any presentation can only be viewed as an example of effective treatments. For additional details, the physician is referred to the Product Monograph and the literature cited therein.
Stability and Storage Recommendations: The recommended storage temperature for the cyclophosphamide dosage forms is 15-25°C (do not exceed 25°C). The dosage forms should be protected from direct light
During transport or storage of Procytox injection vials, temperature fluctuations can lead to melting of the active ingredient, cyclophosphamide. Vials containing melted substance are easily noticeable, since the powder becomes a clear or viscous yellow liquid (seen as droplets or a connected phase in the affected vials). Do not use vials with melted content.
Reconstituted Solutions: The following solutions have been recommended as diluents for intravenous infusion: 5% dextrose USP in 0.9% sodium chloride USP, 5% dextrose USP in sterile water for injection USP, 0.9% sodium chloride USP.
Such solutions are chemically stable for 24 hours at 15-25°C, or 72 hours under refrigeration (4°C). Unless prepared under aseptic conditions, such solutions should be used within 8 hours after dilution.
An oral elixir may be prepared by dissolving the Procytox dry powder contents of the vials in "Aromatic Elixir USP" shortly before administration. This liquid oral formulation, if refrigerated at 4°C, should be used within 14 days.
Solutions of Procytox for parenteral use should be prepared by adding isotonic, sterile, Sodium Chloride Injection USP to the vial, and shaking the contents until dissolution and a clear solution is obtained.
Procytox should not be reconstituted with benzyl alcohol-preserved diluent solution such as bacteriostatic sodium chloride when used in children or infants, due to toxicity concerns in this age group (i.e., gasping syndrome in infants). Further, Procytox should not be reconstituted or diluted with benzyl alcohol-containing diluents, as benzyl alcohol may catalyse the decomposition of cyclophosphamide. Therefore, it is recommended to reconstitute Procytox with isotonic, sterile, Sodium Chloride Injection USP.
Heating should not be used to facilitate dissolution.
Solutions prepared with isotonic, sterile, Sodium Chloride Injection USP should only be used for a single dose administration, and any unused portion should be discarded (see Special Instructions).
Parenteral Products: Reconstitution Table: See Table 2.
Table 2: Procytox
|Vial Size
|Volume of Diluent to be Added to Vial
|Nominal Concentration
| Cyclophosphamide
As with all parenteral drug products, intravenous admixtures should be inspected visually for clarity, particulate matter, precipitate, discolouration and leakage prior to administration, whenever solution and container permit. Solutions showing haziness, particulate matter, precipitate, discolouration or leakage should not be used. Discard unused portion.
Since it has been reported that immersion of a needle with an aluminum component into cyclophosphamide resulted in a slight darkening of the aluminum and gas production after a few days at 24°C with protection from light, it is recommended to avoid the use of utensils, needles or parts of infusion pumps made of aluminum in the presence of Procytox.
Special Instructions: Cyclophosphamide is cytotoxic, carcinogenic, mutagenic and teratogenic. Avoid ingestion, inhalation, or skin and eye contact. Mandatory washing of hands before and after using gloves must be advised. If necessary, consult the Company's Material Safety Data Sheet.
Personnel, regularly handling these agents should have frequent hematologic examinations (CBC), and frequently be screened for urine mutagenesis.
Work-practice guidelines for personnel dealing with and handling cytotoxic and hazardous preparations must be respected, to minimize unnecessary exposure to cyclophosphamide in physicians, nurses, pharmacists, and technicians.
Appropriate Personal Protective Equipment (PPE) must be available in all areas where cyclophosphamide is handled. See Table 3.
Table 3: Procytox
|Activity (when to wear)
|Personal Protective Equipment (PPE)
| Gloves:
Surgical Latex (7–9 mil thickness) or material which provides equal or better protection.
Gloves must be changed at least hourly or immediately if contaminated, torn or punctured.
Wash hands with soap and water after removal of gloves.
| Gown:
Moisture-resistant, long-sleeved gown with cuffs.
Gowns must be changed daily, immediately if contaminated and immediately after spill clean-up.
| Eye Protection:
Eye/face protection (e.g., chemical splash goggles) must be worn when there is hazard of eye contact.
| Mask:
(As approved by Workers Compensation Board)
|If preparing outside a biological safety cabinet
|If hazard of eye contact
|Spill Clean-up
|Waste Disposal
|If waste uncontained
|If waste uncontained
Preparation of Procytox must take place in a Pharmacy or, in facilities where there is not a Pharmacy, in a Class II Type B or better, externally-vented biological safety cabinet. The biological safety cabinet should have airflow monitoring devices and should be certified at least annually. Only luer-lock connections should be used in the preparation of Procytox.
Disposal of cyclophosphamide-contaminated clothing, gloves, utensils, broken glass etc. must be considered as hazardous waste. It must be deposited into a 4 mil thick polypropylene hospital trash bag (properly labelled), or be otherwise segregated and incinerated at above 1000°C. Chemical inactivation should, if possible, be avoided, since it is often ineffective and may produce byproducts that are more mutagenic than the parent drug.
Spills: Cleaning up immediately, and decontaminating areas of spills and breakage by experienced and well-protected personnel is of utmost importance. Contaminated areas including hood interiors must have clearly worded warning labels posted. It is suggested that spill kits be easily accessible, and include replacement hood filters, a respirator ("P3" filter, Manufacturer's current recommendation for cyclophosphamide powder spills), chemical splash goggles, at least 2 pairs of protective gloves, at least 2 sheets (31 cm x 33 cm/12" x 13") of absorbent material, 250 mL and 1 Liter spill-control pillows, a small scoop, spatula, forceps or tweezers to collect glass fragments, and at least two large polypropylene hospital trash bags 4 mil or thicker, or other cytotoxic drug waste-disposal bags, puncture- and leak-resistant waste container for sharp or breakable objects or spilled liquid, and warning sign (e.g., " Danger - Cytotoxic Agent Spill"). Absorbents should be incinerable.


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"Cambodia's ever-growing popularity is seeing more and more travellers choose the stunning nation as an alternative to Thailand."
Although many people head solely to Angkor for its rich wealth of temples, those who look deeper will discover that Cambodia is brilliantly diverse and easy to fall for.
Bordering Thailand, Vietnam and Laos, this fascinating country's unrivalled beauty is underpinned by a turbulent political history, and evidence of the Khymer Rouge's brutal regime can be found at the harrowing Killing Fields, as well as around the reborn capital of Phnom Penh. Sadness and heartbreak lies beneath Cambodian life, but with that comes optimism, as the country grows stronger with every passing day.
Phnom Penh
"Phnom Penh is considered to be one of the most beautiful cities in South East Asia, earning it the title …"
Siem Reap
"Siem Reap has become one of the world's premier travel destinations due to its proximity to Angkor, and now attracts …"
Song Saa
"60 beautiful Cambodian islands pepper the azure Gulf of Thailand, offering up secluded tropical hideaways for those willing to look …"
CambodiaFast Facts
- Time Difference GMT +7 approx
- Currency Cambodian Riel
- Flight Time 14 hours 35 minutes from UK
- Capital Phnom Penh
- Best time to go October to April
Talk to us today
With over 50 years' experience, we're here to help you discover spectacular destinations and luxurious hotels.
Our office is open as follows:
- Monday - Friday 9am - 5.30pm
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- All of our holidays are financially protected through ATOL bonding for your protection.
- 24/7 UK emergency number for complete peace of mind.
- We are ABTA members, ensuring that we are bound by ABTA's code of conduct.


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During your time in Italy, you'll witness the industry in action and gain knowledge from many sites. You'll enjoy delicious food, fine beverages, and fresh agricultural products, and meet passionate professionals and entrepreneurs eager to share their knowledge and unique insights. And you'll visit a number of culturally significant locations such as ancient ruins and museums.
This fast-paced, memorable experience in Italy will bring the foodservice industry to life for you and enrich your overall education at the CIA.
Student Spotlight:Timothy Fisher
"It seemed so simple at first. Go to Italy, eat some food, drink some wine, see some amazing sites, and maybe relax in the sun. But the perspective of hindsight is 20/20 and let me tell you, it was so much more than that."
Read more from CIA Student Tim
View a sample Italy itinerary >
Watch Our Students in Action!
Irulian's Video Journal: The Italy Experience
Episode 1 > | Episode 2 > | Episode 3 > | Episode 4 >
Episode 5 > | Episode 6 > | Episode 7 > | Episode 8 >


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|Michelle Buxton
|Vice President 4's
|Lesley Cairns
|Vice President 3's
|Cassie Allard
|Andrea Cornborough
|Christina Esser
|Samantha Ellis
|Personnel Chair
|Andrea Ryan
|Fundraising Team Co-Chair
|Laura Tayler-Hansen
|Fundraising Team Co-Chair
|Holly Castle
|Grant Writer
|Jennifer Marcoux
Michelle Buxton – President
This is my second year at LVPPP, as my son Riley will be part of the 4's class in September. Riley has a little brother Rhys, who will follow in his footsteps to this preschool in a couple of years. We love the outdoors – especially camping, hiking and biking in the Summer and skiing in the winter. I also love to garden and grew way too many green beans this year!
I will be in the role of President this year and working with the VP's, teachers and all families, I am here to help wherever I can to make the school run smoothly.
Lesley Cairns – Vice President 4's
I am mom to two girls – Madeleine (Maddie) who is in the 4s class and her sister Chloe who is 18 months old. We love to hit the parks, beaches and trails on the North Shore. I have a background in international trade and investment but have been a full time mom since we relocated to Canada from London, UK when Maddie was a baby. I am looking forward to being the VP of the 4s class this year and another fun year of play and exploration at preschool!
Cassie Allard – Vice President 3's
I am the mom of Elanor (3's) and Griffen (grade 1). I really enjoyed my previous role on the communications team and am looking forward to being VP 3's this year. My role is to support the president, work with the executives, and basically help in any way I'm needed. I'll be a liaison between the 3's class and the exec and a go-to for questions and concerns for some of the committees. I am a sahm with a little tutu business and my husband is a computer guy; creating software solutions for a medical imaging company. Our family likes chocolate, mountain biking, and TV.
Andrea Cornborough – Treasurer
This is my second year at LVPPP. My daughter, Leigh, is in the 4s class and i have a little guy, Matthew, at home. We are really enjoying being part of the LVPPP community. I will be continuing on as the Treasurer this year, which involves tracking our spending, setting the budget and reimbursing people's expenses.
Christina Esser – Secretary
I am Mama to Alena in the 4's class. Our son Tillan enjoyed LVPPP and is now in Grade 1. In order to maximize my time with my children I started a home day care for German speakers. Before that I spent 12 years working as a payroll benefit specialist and employee trainer. Every few years we like to spend extended periods in New Zealand or Germany. This year, I'll be the Secretary at LVPPP, which involves keeping minutes of the executive and general meetings as well as keeping track of attendance at the meetings.
Samantha Ellis – Enrolment
I am happy to be returning for my sixth and final year at LVPPP. It has been so much fun and my family has made so many amazing bonds over the years. Natalie is my youngest of three girls and I have spent time in a few different roles, but this year I am enrolment chair. I look forward to meeting, and spending time with, all the new families. In my other life, I am an occupational therapist working in the community two days a week and I love hiking, running, gardening and my book clubs.
Andrea Ryan – Personal Chair
This will be my third year at LVPPP. My youngest is looking forward to joining the 3s class and my oldest is about enter kindergarten. I am going back to work as a teacher after taking 3 years off to be home with the kids. I enjoy going for family bike rides, exploring the local forests, and crafting. As Personnel Chair, I am available to assist with any confidential family matters, difficulties parents may be having with their preschool jobs, various evaluations, and staffing.
Laura Tayler-Hansen – Fundraising Team Co-Chair
I am mom to three super busy, kind and amazing girls, one of which is Teagan in the 4's class. I am looking forward to another great year and to meeting the families at LVPPP. I work part time as a Public Health Nurse.
Holly Castle – Fundraising Team Co-Chair
This is my 2nd year at LVPPP, and it's going to be a busy one! My daughter, Addison is in the 4's class, and my son, Keenan will in the 3's class. As a long time Lynn Valley resident, LVPPP is a special place for me as I attended myself almost 40 years ago! I look forward to collaborating and creating fun community-driven events as Co-Chair of our Ways & Means Committee (aka the "Fun" team) this year. I look forward to connecting with each of you, and welcome any feedback or suggestions on how we can enhance our annual events.
Jennifer Marcoux – Grant Writer
We are back for our fifth year straight at LVPPP! There are so many reasons why we are excited to be back with our third child, Meredith. But mostly we love having the opportunity to watch her grow and develop her own community. We have two other children, Delano (7) and Simone (5) who just graduated from LVPPP. I have held many roles at the preschool from Personnel to President and now Rob and I are taking on the Grant Writer role. Aside from spending time with my three kids, I love vacationing, crafty things, trail runs, wine with friends and attending foodie events. I also work as an HR Director for an Environmental Consulting firm.


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February Favorites
Hello everybody! As you're already probably aware, yesterday was the first day of a fresh new month and so today I will be going through all the things that I loved in the month of February!
I've been binging on a lot of older films & shows lately. I think it's just so interesting to watch the films that I remember watching while I was little; watching them now though, it's completely different. It's never the same feeling watching a kid film/show when you're an adult. There was no such thing as a "cheesy" show when you're a kid.
"Fuller House" is a show that I've been really watching on Netflix. I remember watching "Full House" as a kid and I still to this day will watch it every time it's on TV. That show for sure is a big 'ol cheese ball, but I still love it. This show is what I'd call a "comfort show" if that's even a real thing. Every time I watch Full House or Fuller House, I feel like I'm calm and comfortable. I think it's because I have just grown up watching this show my whole life and it's a huge part of my childhood.
I've also been binging on literally ALL the disney movies I absolutely can, especially the originals. I made my brother download my absolute favorite Disney Princess movie EVER, "Beauty and the Beast". I imagine heaven pretty much being like Disney World.
Now aside from my childhood films, onto my next favorite type of entertainment- BOOKS! These are the books I'm still dying to read and on the top of my reading list! (Thanks to some of Emma Robert's recommendations on Instagram) :
So you all know from last Tuesday's blog that I have recently purchased Colour Pop Matte Lipsticks, but I'm here to say that I absolutely LOVE them!!! The colors that I got were SO pigmented and extremely pretty!! I've received lots of compliments each time I wore them and I will definitely be purchasing more in the near future!
Lastly, I currently own three leather jackets and I've honestly been wearing them everywhere I go. I find that they go great with everything and they are so comfortable to wear! It's safe to say that I'm obsessed with leather jackets and I probably will get a lot more in a lot more different styles. In my opinion, it's definitely a must to have your own collection of leather jackets!- You have no idea how truly comfortable and how many different styles you could create with a leather jacket until you have one! (Trust me!)
Well those are the things that I've been loving throughout the month of February! I'm sorry if today's blog was a bit boring, I haven't really done much last month or experienced anything crazy so films, shows, books, lipsticks, and leather jackets were my shit. Thanks so much for reading and enjoy the rest of your week!


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For its third edition, Salon du Luxe Paris will gather business and brand experts, innovative exhibitors and visionary speakers. For the third year in a row, we're happy to partner with Laura Perrard's unique, interactive and surprising event.
Since 2015, Salon du Luxe Paris is the go-to event for interactive conferences and insightful encounters in the center of Paris. With unique experiences, Laura and her team conceived this third edition to set the new rules for Luxury.
This year, you will have the opportunity to participate into a design fiction immersive experience: the Imprudence Lab will invite visitors to discover three hypothetical visions of the future, 2030, 2050 & 2070, thanks to immersive technologies.
a glimpse into this edition's program
- 9:30 – As an inspiring opening to the event, Eric Briones from Publicis EtNous will present the Luxury Zapping, which is being prepared by our own Allan Joseph, co-founder of Clausette;
- 10:00 – Marie-Claire Daveu, from Kering, will present the group's initiatives for an environmental friendly luxury business;
- 11:20 – M.X. Data and Celine's CIO Dominique Guiffard will talk about I.T.'s new challenges;
- 12:15 – Louis XIII and IFOP's Stéphane Truchi will evoke luxury's new relationship with time;
- 15:00 – A panel talk about luxury in the coming 10 years;
- 18:30 – I will have the pleasure to talk about the new craftsmen with Alain Rousset, from Nouvelle Aquitaine.
win a free ticket for the event!
Want to be part of the event? As part of our partnership with Salon du Luxe Paris, Clausette is offering one lucky winner the opportunity to attend the Salon du Luxe 2017 which is taking place on July 11th 2017. To take advantage of this great opportunity all you have to do is retweet the following tweet:
Want to experience the @salonduluxe in Paris? Retweet this to win your ticket for July 11th! https://t.co/vTjXd7X36Q #RTtowin pic.twitter.com/aRonzKGXuE
— Clausette.cc (@helloclausette) June 20, 2017
Competition conditions
Try your chance and retweet this before Friday July 7th, the winner will be selected at random using Tweetdraw. There are no demographic or geographic entry requirements but before entering you should note the event is taking place in Paris, France, so you will have to make your own way to the venue – as travel costs are not covered by the final prize. All travel or hotel expenses made due to attending the event will be at the winner's own cost. The entry requirements require everyone to have a valid twitter account. Those with accounts considered 'fake' will forfeit entry.
To keep up-to-date with our activities and content, register for our FashTech Bytes Newsletter, follow us on Snapchat, Twitter, Facebook, Instagram & Pinterest for our latest FashTech updates.
Post written by Noémie Balmat, Founding editor-in-chief
Interested in the future of fashion through innovation, Noémie Balmat has a valuable four-year experience in international advertising agencies and works with brands as a FashionTech consultant. She launched Clausette.cc in November 2014 to gather inspiring projects linking fashion & innovation in one place. Sensitive to the technological and scientific evolutions, Noémie often speaks at international events, such as the Hyères International Fashion Festival.


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March 18, 2007
Tessa had a house
Well, people will wonder (I'm just assuming that some people are actually visiting this crap and please don't burst my bubble ;) ) who Tessa is.Tessa is a girl (woman actually) who's responsible for feeding the staff of Tefaf. She makes coffee, cleans up our mess, makes rides to shops,you name it.Some time before Tefaf, she was in Kenya, where she started a centre for orphanages.
Just to promote it a bit, here's a link to it. Click here, or here or there –> or –> here
Give it a visit and just donate some money while you're at it.
(I think she is also hoping to find some volunteers, so while you're sending your money, maybe also donate yourself. Think they can use the extra help).
March 17, 2007
tefaf 2007
Well, let's make a real post now.
School sended me, along with 3 fellow students (the fellowship of the helpdesk if I may call it that way) to the Tefaf.
We had to deploy and manage the network there and give some it support to the users on the fair.
So far (the tefaf is almost finished) it worked out above expetations, since the guy who had to arrange everything for us doesn't have a single clue about networks and how to manage them. The result is that we have crappy equipment, no plan whatsoever and sometimes pissed of users, but someone it all manages to keep working (only had 2 crashes).
The fun part is that without us the guy who had to lead us (the dude is actually a pc farmer (crappy english translation for the dutch "pcboer") would have failed. The networkadressing was crappy (not enough adresses), the new equipment wasn't tested at all, no knowledge about troubleshooting.
But back to our real work here: we had a few days with tons of things to do (second and third day 13 hours of work, fourth day 12,5 hours), but managed to pull it off anyway. After the installation of the network, we had to get all users hooked up with their account. This part was sucky to do, since most of the users were rather pissed at us (2 days behind schedule to give them a connection).
We've even managed to finish our hitlist (laptop that totaly refused to display a website, a crappy mac with some weird airportcardthingie, slow network connections). Now we are just sitting back, waiting for some user to come with some weird problem to solve and trying to make the perfect paper airplane !
2007 fipo !
yeah the first post in the new year ! How cool is that :P
October 19, 2006
covering up some lost time
Well, lots of changes went on in my life for the few months that past since my last post here.
Lets make a little list of what you people all missed from my life ;)
– quit my job and did some small jobs
– relationship with my gf is over after almost a year (but still are friends, which is good)
– had a bloody fine youthcamp
– went back to school (again)
So I'm starting back with an education. Network Infrastructure Design if you want to name it ;)
Also with some luck I'll have my own appartment there in a few weeks, so prepare for some pictures.