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The exactly total of priced domain names was $3,327,525,422.
700 new gTLDs are launching with accredited Registrar 1&1,
Get new domain names from Uniregistry Today!
This is domaining.pro : a domain name for which I have always had a future project to develop but...you know...
A message to frustrated ".com" domainers.
Lesson 1: I do not buy ".com" domain names;
Lesson 2: if you work in the domain name business, you use a domain name ending in ".domains", not ".com";
Lesson 3: I only answer emails ending in ".email", other endings won't be read;
Lesson 4: in regard to domaining, I only visit websites ending in ".domains";
Lesson 5: all this is a joke, I don't buy domain names ;-)
Saturday, March 15, 2014
Frank Schilling's BIN Priced Domains On DomainNameSales Total Over $3 Billion
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The Centre has been making significant strides in developing nanonutrients, nanopesticides and nanoformulations. Keeping in mind deteriorating soil health, growing demand of food, water safety are the biggest challenges, the Centre is uniquely poised to develop path breaking technologies using biologicals interwoven with nanotechnologies and biocompatible materials. Such activities are being pursued jointly through strategic collaborations with Deakin University and partners worldwide.
Research Areas
Nanomaterials in Agriculture
Nanomaterials display several valuable properties such as increased surface area, cation exchange capacity, ion adsorption and complexation not possessed by the bulk materials and these are well known to result in different patterns that enhance adsorption and redox reactions. These nanomaterials could be beneficially used for developing applications for agriculture including smart delivery of agrochemicals, improved storage and controlled release of pesticides and fertilizers and increase crop yields through nutrient management.
Regulatory tools and biosafety
Along with new inventions in the nano technology concerns towards hazards and safety are in the fore front for some time. TD-NBC recognized these urgencies and took lead to develop technologies using biologicals mimicking various complex but effective phenomenon interplaying in nature. Understanding implications of current products and technologies are also being given major emphasis in research agenda of the TD-NBC. Regulatory teeths and requisite inputs to donors both in the government and private sector are some of the high priority activities at the centre currently.
Future Bioformulations
Improving the existing properties of biofertilizers by innovative interventions and understanding natural soil interactions between microbes and plants will provide vital clues for the development of the next generation products for enhanced plant growth that can generate significant benefits to farmers by improving shelf life of biofertilizers, field performance and reducing input expenses not only by cost reduction but by reducing application losses as well.
Seed coating of high value crops
Biological, chemical and physiological characteristics of seeds affect subsequent plant yield, performance and its resistance to undesirable environmental stresses. It is possible to control seed diseases and provide plant protection by treating the seed before planting it and this is achieved by coating the seed with fertilizers, pesticides, nutrients, growth regulators and biologicals along with adhesive agents. Such practices lead to increased benefits to the seed and fertilizer industry. Nanobiotechnology interventions will pave the way to further rationalize smart and precision farming.
Nanomaterial based diagnostics and early detection of diseases
The losses in crop yield due to plant diseases ranges between 20% and 40%. Detection and identification of diseases in crops could be realized via both direct and indirect methods. Nanotechnology innovations have resulted in the advancement of highly sensitive biosensors, the specificity of which could be greatly enhanced by the use of additives like enzymes, antibodies, DNA etc. or use of nanomaterial matrices.
Mycorrhizal elicitation of medicinal molecules from plants
We have developed a true to type novel "in vitro system" for screening and selection of cultivars for the production of medicinal molecules like rosmarinic acid, phenolics, polyphenolics, antioxidants etc. This system holds great promise not only for bioprospecting but also for targeted production of selected, medicinally relevant metabolites. Further innovation using nanomaterials as elicitors expected to enhance efficiency many-folds.
Post-harvest management
Nanotechnology can help in post-harvest management of plant produce by controlling growth and development of microbes by using nanometarials and controlling influence of gases and the harmful rays (UV), increasing strength and quality of packaging coupled with use of nanobiosensors for labeling products.
Large collection of unicellular algae being utilized for production of Bioactives and Biofuel
Microalgae are seen as a promising feedstock for the co- production of a variety of new sustainable products in future. They are high in lipid content and are a rich source of proteins. Highly explored for lipids, microalgae also produce metabolites such as carotenoids, long-chain polyunsaturated fatty acids (LC-PUFA), and vitamins that are widely used in nutraceuticals industries as food additives. Green extraction and milking of metabolites using nanomaterials is a key for the future.
Utilizing algae as bio factories for novel products and improving algal biomass
Products from microalgae (sugars, proteins) make promising platform chemicals from which new materials could be produced. Thus, the potential of microalgae to produce a variety of new bio-products makes them a sustainable and versatile feedstock for future from which many commercial applications could be explored through a biorefinery approach.
Plant-made pharmaceuticals
Referred to as pharming, this field is of immense potential and interest to the biotechnology industry and involves the process of genetically engineering plants to produce therapeutically important compounds and associated molecules. Using inspired discovery, significant leaps can be made in this area for improving quality of human life.
Toxicity assessment of Nanoparticles
Engineered nanomaterials have elbowed their way into our ecosystem including soil, water and atmosphere. Concerns loom about risks posed by engineered nanomaterials, their potential to cause undesirable effects, and contaminate the environment. Information about toxicity and biokinetics of nanomaterials combined with the knowledge of unintentional exposure or intentional delivery for specific purposes will be necessary to determine real risks of nanomaterials. In this regard, some studies are being undertaken at the Centre to determine toxicity of engineered nanomaterial of biological systems based on their mode of application. Foremost in toxicity assessment are the evaluation of human and environmental exposure, and biokinetics, and biopersistence in cells and subcellular structures to perform meaningful lifecycle assessment analysis. Mammalian model systems are being used for this purpose.

subset: commoncrawl


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Don't worry, I didn't forget to pick a winner!
According to our friend random.org the winner is . . .
Thanks everyone for entering!
Sunday, May 1, 2016
Dresden Carnival Giveaway Winner
Posted by Erica at 7:37 PM
1 comment :
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Bellevue Drain Cleaning Services
The Drain cleaning pros at Bob Oates Sewer Rooter and Plumbing are trained to advise you on Sewer Line Cleaning, installation, repair and maintenance so that you understand what's happening every step of the way. We work with every type of sewer and drain component.
With well over 20 years in the business, we have always worked hard to give our clients top quality plumbing service. And our reviews reflect that! When you notice your drains are slowing down or perhaps the sewer line is leaking, call us for drain repair and ask about trenchless sewer line replacement options including sewer camera inspections to help pinpoint problem areas that need to be fixed now or in the future.
Drain and Sewer Installation
Your homes drain and sewer lines have hundreds of thousands of waste run through them every year. The best way to insure long term problem free operation of your sewer system is to have it installed by a professional who has the experience to problem solve correctly and consider issues that may arise years in the future.
Your new home is a big investment make sure one of its must critical components is handled right!
Drain and Sewer Maintenance
Drain clogs mainly build up over time. Taking time to obstruct your drainage. The best way to deal with these issues is to have your drains and sewer lines inspected and maintained regularly. Preventing this problem can often prevent it from blowing up into a bigger more expensive problem. Proper maintenance of sewer and drain lines and having them carefully inspected and the removal of build up, small clogs, and blockages is important to the integrity of drainage lines.
Drain and Sewer Repair
Time and wear take a toll on even the best maintained drain and sewer lines and some point they will need repair. When that time comes make sure you get the best drain and sewer repair company to fix you sewer problem. Your in good hands with Bob Oates Sewer Rooter and Plumbing, one of the areas best sewer service companies. We are not just saying that! Check out our reviews!
Consistent Bellevue drain cleaning will improve drain performance and prevent damage. Call up the Bellevue drain cleaning experts and chat with our friendly staff about any drain cleaning service.
Video Pipe Inspection
These smart tools make getting to the bottom of a sewer problem easy and can save you time, money and frustration. Video drain line inspection cameras makes it easy for our experts to take a close up look inside your drainage system.
The sewer video inspection pros will show up with these tools and get the answers you need quickly.
Trenchless Pipe Replacement
We have modern techniques for dealing with old sewer problems. Trenchless sewer repairs and replacements are an awesome time and money saving advancements. Pipe relining is a great sewer and drain pipes replacement for pipes buried in the ground that would require being dug up in the past. Give us a call today and get to know more about Bellevue trenchless our services.


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Unfortunately, fetal and perinatal mortality rates and risk factors are staggeringly high in the United States, when compared to other developed nations. In 2014, the Yale School of Public Health began testing a group care model designed to fight these trends. After preliminary tests, Yale tapped United Health Group and Spyder Trap to add a layer of technology to the experience. Using this group model as a base, Spyder Trap developed a digital platform that would help expecting mothers experience full-term, healthy pregnancies.
For the past 15 years, investigators at the Yale School of Public Health have been evaluating innovative models of group prenatal care, with documented success in reducing adverse birth outcomes, including a 33% reduction in preterm birth. In 2014, with funding from the United Health Foundation and in partnership with the UnitedHealth Group, they began to enhance the model and work to bring it to scale nationally. They tasked Spyder Trap to build a digital toolkit to be part of Expect With Me group prenatal care, aimed to improve birth outcomes for mothers and babies.
The opportunity was clear. We needed to create an application that would help Yale and UHG empower expecting mothers.
3,239 users over the first six months post launch
Users' average time per session was 9:39 for the six months post launch
Users visited an average of 9.41 pages per session for the six months post launch
After months of collaboration between Yale and UHG, Spyder Trap built a user-friendly responsive website to meet the growing demands of in-person group meetings. The platform allows pregnant women to engage in forums, online learning and log progress in between group sessions. Due to the nature of these in-person group meetings, the software continues to evolve to meet the growing needs of groups and their mentors.
Since it launched in March 2014, 500 women have enrolled in Expect With Me. Despite the fact that the program is still in its infancy, positive feedback has been consistent - especially among group moderators. Likewise, outcomes have been highly positive. With more than 12,500 pageviews in 10 countries so far, the Expect With Me website is sure to change the outcomes of low-income pregnancies by providing support and a safe community for expecting mothers. Yale is currently studying the program to evaluate the impact and scope of this effort.
Start Your Own Web App Project


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Bonobo – Flashlight | New Music
Bonobo is one busy man juggling a string of worldwide shows and the release of brand new EP Flashlight. The EP isn't due out until December 2 but never fear; you can hear title track "Flashlight" below. It gets better. Get your Shazam on whilst listening to the track and you'll be able to download it for free. We can expect nothing less from Flashlight than Bonobo's own brand of electronic beats to get us moving if the title track is anything to go by.
"Flashlight" features a mix of deep kick with an array of percussive samples, ambient synthetic sounds and developing themes, which is a formula that works well for Bonobo. After one listen, you're left floating in anticipation for the next track. Getting used to that feeling will be hard but when December 2 comes, it will be the best sigh of relief you've ever had. Also check out Bonobo's website to find a quirky little Flashlight promotion concept.
Latest posts by WPGM Staff (see all)
- V Festival To Deliver Biggest Weekend In August With JAY-Z And Pink | Music News - June 26, 2017
- JT Soul – 372 ; Velvet Tears EP | New Music - April 2, 2017
- Drake Sheds New Light On Failed J Lo Relationship? | Music News - March 22, 2017


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I have knit a couple of fair isle items - mittens and hand warmers. Both small projects. I knew I had a lot to learn and more then a few hours of practice before I would be happy with anything I made by this method. But why let a little thing like that stop me.
I saw and fell in love with a vest from Vogue Knitting Early Fall 2014 - The Waistcoat designed by Franklin Habit. I loved the vest and thought of my son when I saw it.
I immediately ordered "Bugga" yarn from Verdant Griffon in Black Hole Evaporation (black) and Persephone (red). I walked over to the yarn store and bought the 2 needles I would need. The yarn came, was wound and I cast on. I knit and knit and knit.
And it puckered. It didn't seem like it was puckering as I knit it but it puckering snuck in when I wasn't looking. So I frogged the thing, rewound the yarn and cast on for the second time. I knit and knit and knit and knit. It didn't seem like it was puckering. I searched the web for any tidbit of info I could find. I read enough to convince myself that it wasn't puckering too bad and would come out in the blocking And so I kept knitting. Then I had to start decreasing for the arms and back. As there were less stitches on the needle the stitches started to stretch and I saw, for the first time, what fair isle is suppose to look like. So I frogged the whole thing, again.
I rewound the yarns, again. And for a third time I cast on. I am taking care to spread my stitches this time. At the same time I'm trying to keep the proper yarn tension so I don't get wonky stitches. It is slower then plain stockinette but oh so pretty.
And my concerns over blocking it out have disappeared.
Good thing too because I can just see the look on my sons face as I try to explain blocking to him.


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Matching: system X
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How to Evaluate System Architect Community Blog
LouV Tags: architect" "system architect system 14 Comments 48,509 Views
To evaluate System Architect, go to https://teamblue.unicomsi.com/products/system-architect/ and click the Evaluate tab.
from Blog: IBM System ArchitectModified on by Sarochin T.
A nice clean dump
AnthonyEnglish Tags: kernel support aix device sysdumpdev dumpcheck capture dump crash operating_system data system 9 Comments 22,880 Views
What? A dump? AIX, like many other operating systems, provides the capability of making a system dump. This is nothing to do with the Windows Recycle bin or a Trash folder, a kind of holding place in case you want to undelete something....
Sizing up your file system space (and your worth)
AnthonyEnglish Tags: system decrease jfs2 disk nanoseconds guru chfs gigabyte lv space logical_volume increase aix jfs precious block_size file 8 Comments 35,584 Views
YOUR TIME IS PRECIOUS! When you need to increase a file system, you can use our old friend smitty. But stepping through the SMIT menus could take a good 3 seconds (at least!) And as a good AIX guru, your time is precious. In a perfect world AIX gurus like you...Modified on by AnthonyEnglish
Creating JFS2 file systems? Not so fast!
AnthonyEnglish Tags: jfs crfs mkfs volume lv logical jfs2 system snapshot mount chfs journaled file performance inline cio enhanced 8 Comments 35,105 Views
Often in SMIT you can use the default settings, but when it comes to creating Enhanced Journalled File Systems – better known as JFS2 – there are three options which you'll probably want to change from the defaults. Of course you need to set the MOUNT POINT,...
How to prevent the asset/location from automatically populating in Work Order and Ticket based applications when entering one or the other Community Blog
QiupingMao Tags: ibmeam config location asset system maximo workorder domain 5 Comments 13,563 Views
Maximo has a feature where the system automatically populates the asset when a user enters a location or populates the location when a user enters an asset in the ticket or work order based applications. This is a feature most clients wanted, but there are...
from Blog: Asset Management
At Last! TRIRIGA Performance Best Practices White Paper Community Blog
ChrisEllis Tags: performance practices platform system tririga best config 4 Comments 9,470 Views
The IBM TRIRIGA AP 3.3 Best Practices for System Performance document version 1.0. This paper provides best practices guidelines to improve the performance of products based on the IBM TRIRIGA Application Platform...
from Blog: Real Estate and Facilities ManagementModified on by ChrisEllis
Is a scale out NAS system the same as a scale out file system?
Nils Haustein Tags: bottleneck file storage openstack pnfs smb scaleout nas nfs system spectrum ibm protect scale performance 4 Comments 10,470 Views
by Nils Haustein and Frank Kraemer I recently had some discussions with my peers about the difference of "scale out file systems" and "scale out NAS systems". One of the key observations is: there is a significant difference...
from Blog: StorageneersModified on by Nils Haustein
Rational Developer for System z - enabling a full CICS Explorer experience
JoeWinchester Tags: z/os z rational 8.0.3 cics developer for explorer rd/z system 4 Comments 8,823 Views
This blog entry is about how to surface the full CICS Explorer experience inside RD/z 8.0.3. You can do this by adding the line -Dcom.ibm.cics.explorer.sm.ui.full.enable=true to the eclipse.ini file used to launch RD/z, making sure it's after the -vmargs...
from Blog: Joe Winchester
Announcing the IBM PowerHA SystemMirror for AIX 7.1.3
DinoQuintero Tags: ibm mirror powerha system for aix 3 Comments 5,781 Views
Announcing the IBM PowerHA SystemMirror for AIX 7.1.3 The IBM PowerHA SystemMirror for AIX Standard Edition is the IBM Power Systems data center solution that helps protect critical business applications from outages, planned or unplanned. PowerHA...
from Blog: Dino Quintero's Redbooks Blog
When is a System.gc() not a System.gc()?
IanPartridge Tags: ibm heapdump java system.gc sys system 3 Comments 13,091 Views
Java applications can ask the garbage collector to run by calling the System.gc() method. Generally, this is a bad idea: the garbage collector is designed to run with good performance without intervention from your application. In fact, forcing the garbage...
from Blog: IBM on troubleshooting Java applications
Linux system calls Community Blog
Himanshuz.chd Tags: system kernel user mode 0x80 linux calls 3 Comments 15,559 Views
Any application running on Linux may request services like : Inter process communication I/O services Creating a new process Accessing system hardware etc Note: The above list is not exhaustive. The services listed above are all handled by Linux...
from Blog: Real world Linux
Power Systems POWER8 Reliability, Availability, and Serviceability capabilities by operating system
ScottVetter Tags: computing power power8 redbooks enterprise system 3 Comments 19,069 Views
Selected RAS capabilities by operating system on POWER8 systems This table provides a list of the Power Systems RAS capabilities indicated by operating system. Note that the HMC is an optional feature on scale-out Power Systems servers. Look for a new Chapter...
from Blog: Power Systems IBM RedbooksModified on by ScottVetter
Top 10 Demos for 2010
southworth Tags: rational visualization infosphere system doors cloud optim data cognos appscan architect ilog 3 Comments 9,473 Views
Top 10 Demos for 2010 If you haven't checked out the developerWorks On Demand Demo page, you might want to. developerWorks demos help you discover what a product has to offer ranging from quick product walkthroughs, from installation and setup, and...
from Blog: Video Junkie
Using Rest API on Tivoli's process automation engine, an introduction Community Blog
LeandroCassa Tags: external tpae process srm useful ccmdb system tiny restapi things rest restful integration tivoli engine little automation 3 Comments 10,715 Views
<!-- @page { margin: 0.79in } P { margin-bottom: 0.08in } A:link { so-language: zxx } --&am...
from Blog: Process AutomationModified on by LeandroCassa
ITM Nuggets:How to truly change the hostname of an agent across the whole of ITM Community Blog
MarkLeftwich Tags: monitoring config change hostname value listsystems ibm environment mark teps cli leftwich tacmd name tems tivoli hdt15 managed tep parameter update system setting set 3 Comments 7,472 Views
With the rise of virtualizing physical hardware, many of you are changing the naming conventions in the process. This has led to a spike in issues relating to how to truly change the hostname, across the whole of the ITM infrastructure. This blog...
from Blog: Application Performance ManagementModified on by MarkLeftwich
Smarter Enterprise with Enterprise Architecture Community Blog
JoSubbu Tags: ibm architecture growth system enterprise innovate ea architect 3 Comments 6,101 Views
Enterprise always looks forward for growth. With growth come the challenges such as changes to the organization, resources, etc… that the enterprise needs to face. Whether the growth of an Enterprise is through the merge or acquisition or by itself the...
from Blog: developerWorks India
How to minimize the effects of system failure for Tpae-based products Community Blog
Louise_Lohan Tags: high configuring maximo failure ibmeam availability system 3 Comments 8,637 Views
What do you do when you experience a failure of critical applications? How do you react when the system hangs and you are unable to access vital system content? Are you tempted to take out your frustrations on your computer? You wouldn't be the first person…...
from Blog: Asset Management
Reducing Video Surveillance Storage Costs with the IBM Cloud Object Storage Community Blog
SanjaySudam Tags: object genetec video milestone storwize storage system cloud ibm icos surveillance 3 Comments 9,546 Views
Reducing Video Surveillance Storage Costs with the IBM Cloud Object Storage As the use of camera security surveillance system grows due to increased security concerns, so the demand for the better image quality. Also the demand for the longer video retention...
from Blog: Storage ISVModified on by SanjaySudam
PureApplication System v2 "snapshot" Management and Best Practices
RBoretti Tags: pureapp system pureapplicationsystem virtual snapshot pureapplication 2 Comments 5,089 Views
The snapshot feature in PureApplication System provides the ability to save a copy of the entire state of a Virtual System so you can revert it back to the previous state if desired. A snapshot is intended for use as a restore point if a...Modified on by SteveWebb
nmon - Do we have a serious problem .... or not!
nagger Tags: tl06 time aix system power performance nmon tl05 2 Comments 12,040 Views
I am working with a larger Power 7 customer and learning lots about life in the large and professional computer room. Oh Gosh!!! My Power Virtual Machine (Logical Partition) is totally busy. Oh Heck!!! Look at all that System time, we have a serious problem!!...
from Blog: AIXpert Blog
What were they Thinking?
firstname.lastname@example.com Tags: system risk horizon deepwater gulf oil bp spill 2 Comments 5,485 Views
First, some personal disclosure: In the late 1980's, I worked for a while at Shell Research, developing seismic modeling and data imaging algorithms. ( See this link .) While there I received training on oil exploration. I remain awed by the passion,...
from Blog: Murray Cantor
AIX 6.1 TL7 : 2 bugs in IBM System Director Common Agent
AIX 6.1 TL7 includes IBM Systems Director Common Agent (cas agent). It is installed as part of the System Management Client Software bundle which is part of the default install options. Unfortunately, this new component introduce 2 small bugs including one...
from Blog: AIX, Power Systems, Storage... and more
Is your system ready for WebSphere MQ to be deployed?
ValerieLampkin Tags: configuration websphere deploy mqconfig mq administration semaphores kernel system tuning ipc 2 Comments 13,165 Views
Have you checked your system parameters? Often System Administrators are asked to install the WebSphere MQ Software and are not given the necessary background information to prepare their system and perform the kernel tuning parameters necessary for optimum...
An Optimized Security Environment Built with IBM Security (Demo) Community Blog
mpdugg Tags: manager infosphere network qradar web system demo endpoint appscan prevention gateway security intrusion guardium enterprise ibm 2 Comments 4,298 Views
Security involves many activities: controlling user access, hardening applications, inspecting network traffic, patching systems, and monitoring databases, among others. IBM offers solutions for all of these. However, optimum security requires gaining insight...
from Blog: Ready for IBM Security Intelligence - NewsModified on by mpdugg
5 things you should know about IBM Spectrum Scale (formerly GPFS)
5 things you should know about IBM Spectrum Scale (formerly GPFS) Spectrum Scale now part of IBM Spectrum Storage family, part of IBM's $1 Billion investment in software defined storage. Single global namespace across all data tiers, including...
from Blog: Dino Quintero's Redbooks Blog


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In my kitchen, I have two pantry drawers devoted to make storage: 1 for alliums and 1 for potatoes. Both are constantly stocked, ready to make any meal. As this kind of, I have an arsenal of recipes that use these ingredients. I've produced harissa potatoes prior to but this meal is a bit more considerable with aid from chickpeas and crushed tomatoes. These harissa potatoes are also fantastic reheated the next day. Go through more and see the recipe.
The post Harissa Potatoes more than Garlicky Kale appeared very first on Naturally Ella.


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There are two basic kinds of beer: ales and lagers. It's all about yeast's preferences. Some yeasts like it on top, some prefer to be on bottom. Up until now, yeasts have not been more creative in their brewing positions, but we can always fantasize.
Ale yeasts like it on top and will ferment at higher temperatures (60-70°F) and so are quicker finishers than lagers (1-3 weeks). Usually ales are sweeter and have a fuller body, which really starts to take this sexual allusion to extremes.
Lagers, on the other hand, use yeasts that settle in at the bottom to do their work and prefer colder temps of about 40-55°F. They take 1-3 months to ferment. Lagers tend to be lighter and drier than ales and are the most common beers, often easier to get along with for the average drinker and they don't mind if you leave the seat up. (In fact, you may as well, you'll be coming back a few times before the night is done.) For lager we can thank the Bavarians who—when they found that cold temperatures could control runaway wild yeasts in the warm summer ale batches—moved them to the Alps. The name lager comes from the German "to store."
Ale is the first real beer that was made and it was sort of a mutation of another alcoholic drink called mead. This was made with fermented honey. Remember the mead halls when you read Beowulf in school? OK, I didn't read it either, but the Cliffs Notes mentioned it some. This is the sweet and potent concoction that put the happy in the Vikings as they raped, pillaged and plundered. Someone added a bit of hops, and later some malt, and the hybrid brackett evolved.
While occasionally you will hear of brewers using ale yeast at temperatures closer to lager brewing, all beer styles that you know and love generally fall into these two categories. Stouts, porters, wheat beers (among others) are ales, while pilsners, bocks, and dunkels fall into the lager column.
Kevin Revolinski has written several books, including Wisconsin's Best Beer Guide. He has spent numerous years abroad and is also the creator of The Mad Traveler. Revolinski will be informing Hops readers about the wonders of beer in a special six-part series on his favorite form of happiness.


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In 2005 . . .
A few friends who lived in and around Baldwin Park were talking about starting a church that would be part of the Lake Baldwin neighborhood and whose impact would touch not only the city of Orlando but the world! They envisioned a community where people could worship God, connect with each other, grow in the gospel, raise families together, network, and give back to their community. And this is only the beginning. . . Won't you join us as the story unfolds?


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Sleeping icons9 Feb 2014 06:29 pm
I was supposed to be writing this weekend, but couldn't wrap my head around it. Instead I've spent a couple of hours making icons. I said in a previous post that I really needed a 'sleepy' icon, so I searched out some pics of people and animals sleeping and then cropped and played around with different parts of the images I found.
( Under the cut are the results )
( Under the cut are the results )


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Research Topics
Genomes and Genes
Gene Symbol: Nat2
Description: N-acetyltransferase 2
Alias: Nat2a, arylamine N-acetyltransferase 2, AT-2, N-Acetyltransferase-2 (arylamine N-acetyltransferase), N-acetyltransferase 2 (arylamine N-acetyltransferase), N-acetyltransferase type 2, NAT-2, arylamide acetylase 2
Species: rat
Top Publications
Research Grants
Scientific Experts
Detail Information
- Haplotype of N-acetyltransferase 1 and 2 and risk of pancreatic cancerLi Jiao
Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Epidemiol Biomarkers Prev 16:2379-86. 2007We examined the association between N-acetyltransferase 1 and 2 (NAT1 and NAT2) haplotype and risk of pancreatic cancer by genotyping eight NAT1 and seven NAT2 single nucleotide polymorphisms in 532 patients and in 581 healthy controls (..
- The association between N-acetyltransferase 2 gene polymorphisms and pancreatic cancerLokman Ayaz
Medical Faculty, Department of Biochemistry, Mersin University, Mersin, Turkey
Cell Biochem Funct 26:329-33. 2008..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) are expressed primarily in extrahepatic and hepatic tissues, respectively...
- Association between genetic polymorphisms of CYP1A2, arylamine N-acetyltransferase 1 and 2 and susceptibility to cholangiocarcinomaA Prawan
Department of Pharmacologygery, Faculty of Medicine, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, 40002, Thailand
Eur J Cancer Prev 14:245-50. 2005..The present study aimed to evaluate the relationship between CYP1A2, NAT1 and NAT2 polymorphisms and cholangiocarcinoma (CCA), the most prevalent cancer in the north-east of Thailand...
- Polymorphism of arylamine-N-acetyltransferase 2 gene is associated with the risk of atopic dermatitisS I Makarova
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Russia
Bull Exp Biol Med 139:662-4. 2005..Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects...
- N-acetyltransferase 2 phenotype may be associated with susceptibility to age-related cataractLulufer Tamer
Department of Biochemistry, Mersin University, Medical Faculty, Mersin, Turkey
Curr Eye Res 30:835-9. 2005..Genotyping of NAT2 polymorphisms were detected by using a LightCycler-NAT2 mutation detection kit in real-time PCR...
- N-acetyltransferase 2 gene polymorphism and presbycusisMurat Unal
Departments of Otorhinolaryngology, Faculty of Medicine, Mersin University, Mersin, Turkey
Laryngoscope 115:2238-41. 2005..The effect of aging shows a wide interindividual range; we aimed to investigate whether profiles of NAT2 genotypes may be associated with the risk of presbycusis.
- Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitisMuradiye Nacak
Department of Pharmacology, Faculty of Medicine, Gaziantep University, Turkey
Int J Dermatol 45:323-6. 2006N-acetyltransferase 2 (NAT2) polymorphism may be involved in the pathogenesis of allergic contact dermatitis.
- Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylatorsMousumi Majumder
Human Genetics Unit, Biological Sciences Division, Indian Statistical Institute, 203 B T Road, Kolkata 700108, India
Int J Cancer 120:2148-56. 2007Polymorphisms at N-acetyl transferase 2 locus (NAT2) lead to slow, intermediate and rapid acetylation properties of the enzyme. Improper acetylation of heterocyclic and aromatic amines, present in tobacco, might cause DNA adduct formation...
- Ocular defects associated with a null mutation in the mouse arylamine N-acetyltransferase 2 geneLarissa Wakefield
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Mamm Genome 18:270-6. 2007The xenobiotic metabolizing enzyme, mouse arylamine N-acetyltransferase type 2 (Nat2), is expressed during embryogenesis from the blastocyst stage and in the developing neural tube and eye...
- NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosisNorihide Higuchi
Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
World J Gastroenterol 13:6003-8. 2007To investigate an association between N-acetyltransferase 2 (NAT2)-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients.
- Interaction effect in bladder cancer between N-acetyltransferase 2 genotype and alcohol drinkingChih Ming Lu
Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Urol Int 75:360-4. 2005Cigarette smoking, aromatic amines and ionizing radiation are known carcinogens of bladder cancer. NAT2 genotype might play a role in bladder cancer carcinogenesis...
- Effects of genetic polymorphisms of N-Acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workersYufei Dai
National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Nanwei Road 29, Beijing, 100050, P R China
Ind Health 47:479-86. 2009..fragment length polymorphism was used to detect the polymorphic sites of NAT1 at nt 1095 and 1088 and the sites of NAT2 at nt 481, 590, and 857...
- Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failureMélina Dani
Centre de Recherche de l Hôpital Maisonneuve Rosemont, Faculte de Medecine, Universite de Montreal, Quebec, Canada
Drug Metab Dispos 38:357-60. 2010..is related to a decrease in liver cytochrome P450 (P450) and phase II enzymes, particularly N-acetyltransferase 2 (NAT2)...
- A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility lociNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Nat Genet 42:978-84. 2010..3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions...
- Genetic variability in N-acetyltransferase 2 gene determines susceptibility to childhood lymphoid or myeloid leukemia in BrazilCrisiane Wais Zanrosso
Pediatric Hematology Oncology Program, Research Center, Instituto Nacional de Cancer, Rio de Janeiro, Brazil
Leuk Lymphoma 53:323-7. 2012..Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals. N-acetyltransferase 2 (NAT2) SNP 341T > C frequency was higher among both leukemia subtypes compared to controls...
- CYP3A5 and NAT2 gene polymorphisms: role in childhood acute lymphoblastic leukemia risk and treatment outcomeVanessa S Silveira
Department of Pediatrics, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, HCFMRP Bloco G, 1a, Sl 218 Bairro Monte Alegre, CEP 14049 900, Ribeirao Preto, SP, Brazil
Mol Cell Biochem 364:217-23. 2012..This study aimed to evaluate the impact of the CYP3A5 and NAT2 metabolizing enzyme polymorphisms on the risk of childhood acute lymphoblastic leukemia...
- Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control studyLisa F Potts
Department of Anatomical Sciences and Neurobiology, University of Louisville, KY, USA
BMC Med Genet 13:16. 2012..functioning, or oxidative stress response, including debrisoquine 4-hydroxylase, paraoxonase 1 and 2, N-acetyltransferase 1 and 2 (NAT2), superoxide dismutase 1 and 2, and PTEN-induced putative kinase are associated with PSP.
- Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in ratsXiangyang Li
Department of Pharmacy, Qinghai University Medical College, Xining, China
Pharmacology 93:76-83. 2014..chronic high-altitude hypoxia (AHH and CHH) on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats...
- N-Acetyltransferase 2 (NAT2) polymorphism as a risk modifier of susceptibility to pediatric acute lymphoblastic leukemiaAzza M Kamel
Clinical Pathology Department, NCI, Cairo University, Fom El Khalig square, Kasr El Aini St, Cairo, 11796, Egypt
Tumour Biol 36:6341-8. 2015N-Acetyltransferases (NAT) have been known to modify the risk to a variety of solid tumors. However, the role of NAT2 polymorphism in risk susceptibility to childhood acute lymphoblastic leukemia (ALL) is still not well known...
- N-acetyltransferase 2 polymorphisms in patients with Behcet's diseaseL Tamer
Department of Biochemistry, Mersin University, Turkey
Clin Exp Dermatol 30:56-60. 2005..induce an autoimmune mechanism, the aim of the present study was to investigate whether the genetic polymorphism of NAT2 plays a role in susceptibility to Behcet's disease...
- Polymorphisms of the xenobiotic-metabolizing enzymes CYP1A1 and NAT-2 in systemic sclerosis and lupus erythematosusS von Schmiedeberg
Department of Dermatology, Heinrich Heine University Dusseldorf, Germany
Adv Exp Med Biol 455:147-52. 1999..Thus, enhanced formation of reactive metabolites could alter self-proteins presented to the immune system thus stimulating autoreactive T cells which induce autoimmunity...
- Polymorphisms of NAT2 in relation to sulphasalazine-induced agranulocytosisM Wadelius
Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala, Sweden
Pharmacogenetics 10:35-41. 2000..The polymorphic enzyme N-acetyltransferase 2 (NAT2) plays an important role in the metabolism of sulphasalazine...
- Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasiasM C Lemos
Medical Genetics Unit, Faculty of Medicine, University of Coimbra, and Department of Clinical Haematology, University Hospital of Coimbra, 3049 Coimbra Codex, Portugal
Carcinogenesis 20:1225-9. 1999..polymorphisms of cytochrome P450 2D6 (CYP2D6), glutathione S-transferase M1 (GSTM1) and N-acetyltransferase 2 (NAT2) and an altered risk for haematological neoplasias...
- Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control studyDavid W Hein
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Environ Mol Mutagen 40:161-7. 2002N-acetyltransferase-1 (NAT1) and N-acetyltransferase-2 (NAT2) are important in the metabolism of aromatic and heterocyclic amine carcinogens that induce prostate tumors in the rat...
- Association of genotypes of carcinogen-activating enzymes, phenol sulfotransferase SULT1A1 (ST1A3) and arylamine N-acetyltransferase NAT2, with urothelial cancer in a Japanese populationShogo Ozawa
Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan
Int J Cancer 102:418-21. 2002..and O-acetylation by phenol sulfating sulfotransferase, ST1A3 (SULT1A1), and arylamine N-acetyltransferase, NAT2, respectively...
- Slow acetylator genotypes as a possible risk factor for infectious mononucleosis-like syndrome induced by salazosulfapyridineT Ohtani
Department of Dermatology, Wakayama Medical University, Kimiidera, Wakayama, Japan
Br J Dermatol 148:1035-9. 2003..SASP is known to be mainly metabolized by N-acetyltransferase 2 (NAT2), and acetylation phenotypes (rapid, intermediate and slow acetylator) correlate with NAT2* genotypes...
- Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's diseaseO Bandmann
University Department of Clinical Neurology, Institute of Neurology, London, UK
Lancet 350:1136-9. 1997..We investigated the frequency of functionally relevant polymorphisms in six detoxification enzymes among patients with PD to elucidate the relation between these polymorphisms and the disease...
- N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjectsH Brocvielle
Laboratoire d ingénierie et de biologie cutanées, Faculte de Medecine et de Pharmacie, Besancon, France
Skin Pharmacol Appl Skin Physiol 16:386-92. 2003The genetic polymorphism of human N-acetyltransferase 2 (NAT2) divides the human population into groups with rapid, intermediate and slow acetylator status...
- NAT2 genotyping and efficacy of sulfasalazine in patients with chronic discoid lupus erythematosusN Sabbagh
Laboratoire de Biochimie et Biologie Moléculaire de l Hôpital Calmette, Universitaire de Lille, France
Pharmacogenetics 7:131-5. 1997..in metabolism of the drug which is extensively acetylated by the polymorphic enzyme N-acetyltransferase 2 (NAT2)...
- N-acetyltransferase 2 polymorphisms and susceptibility to infant leukemia with maternal exposure to dipyrone during pregnancyCrisiane Wais Zanrosso
Pediatric Hematology Oncology Program, Research Center, Instituto Nacional de Cancer, Rio de Janeiro, Brazil
Cancer Epidemiol Biomarkers Prev 19:3037-43. 2010..N-Acetyltransferase 2 (NAT2) enzyme acetylates dipyrone, resulting in a detoxified metabolite...
- Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmaticsJin Moo Kim
Genome Research Center for Allergy and Respiratory disease, Soonchunhyang University Bucheon Hospital, 1174 Jung dong, Wonmi gu, Bucheon, Gyeonggi do 420 767, Republic of Korea
Pharmacogenomics 11:951-8. 2010..Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the risk of aspirin-intolerant asthma...
- Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disordersA Hirvonen
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland
J Natl Cancer Inst 88:1853-6. 1996..e., both copies lost) of these genes can be detected. Polymorphism of the NAT2 gene results in slow and fast acetylators of potentially toxic substances...
- GSTT1, GSTM1, GSTM3 and NAT2 polymorphisms in laryngeal squamous cell carcinoma in a Greek populationM Chatzimichalis
Department of Otolaryngology Head and Neck Surgery, METAXA Anticancer Hospital, Piraeus, Greece
J Laryngol Otol 124:318-23. 2010..Accumulating evidence suggests that alterations of detoxification enzymes, such as glutathione S-transferases and N-acetyltransferases, influence the risk of cancers associated with tobacco smoke and alcohol...
- N-acetyltransferase-2 polymorphism, smoking and type 1 diabetic nephropathyE Korpinen
Hospital for Children and Adolescents, University of Helsinki, Finland
Pharmacogenetics 9:627-33. 1999The N-acetyltransferase (NAT2) polymorphism has been suggested to be related to diabetic microvascular complications...
- Recombinant rat and hamster N-acetyltransferases-1 and -2: relative rates of N-acetylation of arylamines and N,O-acyltransfer with arylhydroxamic acidsR F Jones
Molecular and Chemical Carcinogenesis Program, Karmanos Cancer Institute, Wayne State University College of Medicine, Detroit, MI 48201, USA
Carcinogenesis 17:1729-33. 1996Genes for the 290 amino acid, 33-34 kDa cytosolic acetyltransferases (NAT1* and NAT2*) from rat and hamster were cloned and expressed in Escherichia coli...
- Impact of interaction of polymorphic forms of p53 codon 72 and N-acetylation gene (NAT2) on the risk of lung cancer in the North Indian populationRanbir C Sobti
Department of Biotechnology, Panjab University, Chandigarh, India
DNA Cell Biol 28:443-9. 2009..We studied the influence of NAT2 and codon 72 p53 polymorphisms on 151 patients with lung cancer and an equal number of matched population controls...
- Cloning, sequencing and expression of NAT1 and NAT2 encoding genes from rapid and slow acetylator inbred ratsM A Doll
Department of Pharmacology and Toxicology, University of North Dakota School of Medicine, Grand Forks 58202 9037, USA
Pharmacogenetics 5:247-51. 1995
- Complementary DNAs for two arylamine N-acetyltransferases with identical 5' non-coding regions from rat pineal glandT Ebisawa
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Japan
Eur J Biochem 228:129-37. 1995....
- 4-Aminobiphenyl downregulation of NAT2 acetylator genotype-dependent N- and O-acetylation of aromatic and heterocyclic amine carcinogens in primary mammary epithelial cell cultures from rapid and slow acetylator ratsFelicia A Jefferson
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Toxicol Sci 107:293-7. 2009..N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) enzymes have important roles in their metabolic activation and deactivation...
- Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the ratDavid F Barker
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Drug Metab Dispos 36:2445-51. 2008Human N-acetyltransferase 1 (NAT1) and 2 (NAT2) are important phase II enzymes involved in the biotransformation of xenobiotics...
- Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic ratDavid W Hein
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
Drug Metab Dispos 36:2452-9. 2008Rat lines congenic for the rat N-acetyltransferase 2 [(RAT)Nat2] gene were constructed and characterized. F344 (homozygous Nat2 rapid) males were mated to Wistar Kyoto (homozygous Nat2 slow) females to produce heterozygous F1...
- Interaction of the cytochrome P4501A2, SULT1A1 and NAT gene polymorphisms with smoking and dietary mutagen intake in modification of the risk of pancreatic cancerHideo Suzuki
Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Carcinogenesis 29:1184-91. 2008..Cytochrome P450 (CYP) 1A2, N-acetyltransferase (NAT) 1, NAT2 and sulfotransferase (SULT) are enzymes involved in the metabolism of these carcinogens...
- 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred ratsM Purewal
Department of Gastrointestinal Medical Oncology and Digestive Diseases, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer Epidemiol Biomarkers Prev 9:529-32. 2000..N-Acetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form...
- Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variantJason M Walraven
Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
Toxicol Sci 99:413-21. 2007Human arylamine N-acetyltransferases NAT1 and NAT2 are highly polymorphic genes that modify individual susceptibility to cancers caused by exposure to arylamine procarcinogens...
- Acinar distribution of rat liver arylamine N-acetyltransferase: effect of chronic ethanol and endotoxin exposurePavel S Pronko
Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno
Pharmacol Toxicol 90:150-4. 2002....
- Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary diseaseEhtesham Arif
Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
Clin Chim Acta 382:37-42. 2007..Detoxification genes are potential candidates in the susceptibility of patients with chronic obstructive pulmonary disease. Polymorphisms in these genes alter the metabolism of xenobiotics such as present in cigarette smoke...
- Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthmaLulufer Tamer
Department of Biochemistry, Faculty of Medicine, Mersin University, Mersin, Turkey
Tuberk Toraks 54:137-43. 2006..The aim of the present study was to investigate further whether the genetic polymorphism of the NAT2 plays a role in susceptibility to bronchial asthma disease...
- N-acetyltransferase 2 polymorphism in patients with diabetes mellitusSerap Yalin
Mersin University Pharmacy School, Department of Biochemistry, Mersin, Turkey
Cell Biochem Funct 25:407-11. 2007..06; 95%CI: 10.55-209.77 for NAT 2*5A, OR = 18.48; 95%CI: 3.83-89.11 for NAT2*6A and OR = 18.22; 95%CI: 6.29-52.76 for NAT2*14A)...
- Nomenclature for N-acetyltransferasesK P Vatsis
Department of Pharmacology, Medical School, University of Michigan, Ann Arbor 48109 0632, USA
Pharmacogenetics 5:1-17. 1995..For designation of genotypes at a single NAT* locus, a slash serves to separate the alleles; in phenotype designations, which are not italicized, alleles are separated by a comma...
- [Analysis of the N-acetyltransferase 2 gene polymorphism in the patients with chronic obstructive pulmonary disease and in populations of the Volga-Ural region]T V Viktorova
Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia
Genetika 39:855-7. 2003Restriction fragment-length polymorphism of the gene coding for N-acetyltransferase 2 (NAT2) was typed in populations of the Volga-Ural region (Bashkirs, Tatars, Chuvashes, Udmurts, and Russians) as well as in patients with chronic ..
- 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the ratXiaoyan Zhang
Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40292, USA
J Pharmacol Exp Ther 316:289-94. 2006..MDA undergoes N-acetylation catalyzed by N-acetyltransferase 1 (NAT1) and 2 (NAT2) in the liver...
- Genetic polymorphism of N-acetyltransferase 2 in the susceptibility to laryngeal squamous cell carcinomaMurat Unal
Mersin Universitesi Tip Fakultesi Hastanesi, KBB Anabilim Dali, Zeytinlibahce Cad, 33079, Mersin, Turkey
Head Neck 27:1056-60. 2005The purpose of this study was to investigate whether polymorphism of N-acetyltransferase 2 (NAT2) genotypes are associated with the risk of laryngeal squamous cell carcinoma (SCC).
- Pleural malignant mesothelioma, genetic susceptibility and asbestos exposureMonica Neri
Unit of Epidemiology and Biostatistics, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genoa, Italy
Mutat Res 592:36-44. 2005..The role of mEH, GSTM1, GSTT1, NAT2, and CYP1A1 genotypes in modulating susceptibility to MM was examined in a case-control study of 80 subjects with a ..
- Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned ratsM Grundmann
Department of Neurology, Philipps University, Marburg, Germany
Exp Neurol 187:199-202. 2004We previously reported an association between the N-acetyltransferase 2 (NAT2) slow acetylator status and Parkinson's disease (PD)...
- 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibilityEvgeniya V Belogubova
Group of Molecular Diagnostics, N N Petrov Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
Cancer Lett 221:177-83. 2005b>NAT2 (arylamine N-acetyltransferase 2) polymorphism, being a key determinant of individual variations in acetylation capacity, is suspected to modify the risk of carcinogen-related malignancies...
Research Grants1
- PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISMDavid Hein; Fiscal Year: 2009..breast cancer in those individuals with rapid and/or slow acetylator N-acetyltransferase- 1 (NAT1) and - 2 (NAT2) acetylator genotypes...


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This is will be our reading for June 10th. You can find all the details on our Meetup.com page.
Chapter 1: Introduction
There are several questions any account of freedom needs to be able to answer, with three being the most obvious. First, what is freedom, or what would it mean to act freely? Second, is it possible to act freely? Third, how important is leading a free life?
These days, these sorts of questions are folded into an area of research called "practical philosophy," which has two questions of its own. First, are there events that we can demand justifications for, or are all events caused in the same uniform way? Is there a real distinction between a human act and a rock rolling downhill? Second, if the answer to the first question is yes, then we need to ask what counts as a good justification.
Hegel's theory of freedom, as a theory of both action and value, is his answer to all of these questions. The standard description of Hegel's theory says it has two elements. First, to be free is to have a reflective and deliberate relation to one's actions, and second, that this is only possible when one is in a certain (institutional and rule-governed) relation to others.


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|Reviews for Delta
| Stuch chapter 4 . 3/16/2011
It's all ticking along quite nicely, fleshing out the characters a bit. I'll admit I was worried you were going to cross over with the main canon - I think Sev meets up with a Delta Company when taking on the arc towers in Killzone2's campaign - and was glad that avoided the temptation.
Always more fun to write your own stuff anyway.
| Stuch chapter 3 . 3/13/2011
Down time is important and there's more time to learn about characters when bullets aren't flying over their heads. I like the back stories and would be interested to know why Z joined the ISA if not to get some payback like the other two.
| Stuch chapter 2 . 3/11/2011
Both of my criticisms of your prologue are fixed in this first chapter, fantastic. Keep it up.
| Stuch chapter 1 . 3/11/2011
A few grammar mistakes (your, you're) and messing up of the tenses. But other than that it's a good, solid opening. Looking forward to seeing where you take it.


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In last month's article, we looked deep into the pipes of an old two-pipe gravity circulation system. We will now continue looking at the history and advances of these wonderful mechanical systems.
In this very same neighborhood near Capitol Hill, I came across a single-pipe gravity system that had its piping pitched upward from the gravity heat source, just like the two-pipe system. However, this system utilized a special fitting called a Eureka fitting. The Eureka tee was co
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Showing all content tagged 'Models' and posted in for the last 365 days.
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- Today
Sharkbelly Visits the Silver Tower
Sharkbelly replied to Sharkbelly's topic in Painting and ModellingSCREAMERS!!!!!
- Last week
The Greenboyz mega catchup post #1 (52 minis weeks ???)
Randroid posted a goblog entry in Drinkin' and Modelin' - Gaming and BeerHi blog. Hi couple of you that read this from time to time. Long time no see. Hope things are going well for you in life. Things are going very well for me and I have been quite busy working on a fun little Goblin team for Blood Bowl. The Greenboyz! Those Blood Bowl fans out there may recognize The Greenboyz from their one appearance in White Dwarf issue #101 with this little snippet: Things weren't going so well for The Greenboyz back in that season but they turned it around for the 2487-2488 season when they managed to crush every team in their way to the championship. What happened you ask? Well nobody really knows... but most everyone is pretty sure it had to do with cheating. The Greenboyz roster from their winning season in 87-88 Earlier this year I was invited to participate in a special kind of Blood Bowl event that focused on the Teams of Legend from Death Zone Season 2. While I wasn't planning on creating and painting a Goblin team when the chance came up to take on the role of Head Coach for The Greenboyz I just couldn't say no! (and it wasn't even because of the copious amounts of ale I was bribed with I swear) And so the construction of this mighty team of legend began with... bunch of shopping and chopping. My goals for the team were: 1. Create a cohesive looking team of Goblins with various model ranges including GW. 2. Show each of the "skills" for the player in a visual way with conversions. 3. Have fun and embrace the Goblin aesthetic of The Greenboyz. I'm pretty sure I achieved all of these goals and more! Once the main body of the team was complete I began work on the pieces I wanted for the sidelines. One of these was very important... a way to represent The Greenboyz constant Fame +2. I chose to model stands full of drunk fans and also build an early Mark I version of "The Monstrous Mangler" - the most impressive secret weapon to ever exist, and ultimately the secret weapon which killed off the triumphant Greenboyz in the year 2492. In my version of this secret weapon the Goblins created a way to drive the actual stadium stands on to the pitch in the ultimate of pitch invasions! Still needed a few more sideline figures like Coaches, Cheerleaders, and the Apothecaries. I managed to get that done as well as the start of the team bus! My vision for the bus was simple and recognizable. A very famous goblin truck... With the added sideline complete it was time for a color scheme. Since The Greenboyz did not have official GW colors from the fluff (unlike most Teams of Legend) I worked up a color scheme that was really focused on both Goblins and the name Greenboyz. GREEN With my test model done I moved on to the massive painting project of all the fans in the stands, the sideline minis, and finally the team. I also managed to bodge up a couple more Goblins for when the stars of The Greenboyz want some back up (or get squashed by other Blood Bowl teams) and to fill up the roster. Next time... what happened at Legends Cup? Where else did The Greenboyz play (hint: it was Chaos Cup)? What is in store for the team moving forward? Check back here for more details Goblin fans!
Sculpting Tutorials
Karak Norn Clansman replied to Karak Norn Clansman's topic in Painting and ModellingClick here for more information on Bronze Age Aegean helmets.
Farmer's Undead
Farmer7574 replied to Farmer7574's topic in Painting and ModellingFour Hexwraiths all ready for some paint: And here's the Hellwraith I repositioned to make more imposing: Conversions are pretty simple – the usual forest basing, and then we have flames green stuffed on the mounts' eyes, robes and some of their snouts. I haven't used the flaming heads yet, probably for the reason that I like the simplicity of the wraiths I've assembled here but I'm wandering whether a last minute head swap could be in order - after all they are a special unit and the flames on these miniatures is one of the most appealing aspects of them... Cheers for taking a look.
- Earlier
Sharkbelly's Ships and Sea Creatures
Sharkbelly replied to Sharkbelly's topic in Painting and ModellingThe rest of the band is now finished.
Countdown - 2 days - final push
Belchfist Beastkiller posted a goblog entry in Belchfist's Realm of MadnessSo I have but a few hours of modelling time left before my friend arrives on Sunday (I work heavily on the weekends - very long days). So have just an hour or so this evening to get some finishing touches in. I have put aside the scenery for the most part, it is up to a just about acceptable standard. I have never used the oxide wash technical paint before (can't remember the proper name for it), and I was a little heavy handed/have used it wrong. So I'm not too keen on some of that on the mausoleum as you can see here: But, as I said, it's acceptable and I had no scenery at all previously other than the Baleful Realmgates so I'm pretty psyched about getting some battles in with this stuff. Especially Skirmish! I can't remember if I included this in the previous post, but I managed to basecoat almost every colour on the Warchanter, so he won't be a standout black model on the table (only the gore-gruntas will do that from my side *sad face*). Here are some (very dodgy) pics of the army arrayed on top of my desk with horrific lighting: I have bought some fine detail pens with which I intend to add some black detailing to the armour and then cover with freehand painting to stop it shining (unless anyone can recommend a matt gloss that would work as well...?) and will update with pics when possible. On a different note...I was casually reading white dwarf and realised I had kind of achieved a 17 year old life goal of mine; to have a model featured in White Dwarf magazine. It's not even a model I'm particularly proud of from my Bloodbound as it was fairly rushed, but beggars can't be choosers and there it is! It's a proper honour to be included with some incredible models from other painters from around the world! Proud! BB
Beastclaws Ice Mammoth!
Belchfist Beastkiller replied to I R GMAN's topic in Painting and ModellingThis is awesome! What rules will you use?
Countdown - 4 days...procrastination
Belchfist Beastkiller posted a goblog entry in Belchfist's Realm of MadnessSo I popped in to GW as I had some spare time and it proved to be an error. I bought the Sigmarite Mausoleum kit. I did this in a fit of impulse so that the games we played would have some awesome scenery. I then spent the next 8 hours building it and slapping some paint on it! I've also got my Weirdnob Shaman to an acceptable point. I'm not certain about the smoke but as it's my first attempt at painting magical smoke I'm quite happy! Also shown are some river sections I made a few years back...I'm not sure you can see but they have not stored well! The result of using thin cereal box cardboard and pva before water effects! Booo! also Baleful Realmgates with some paint to match the Mausoleum.... It's all happening! BB
Countdown - 7 days
Belchfist Beastkiller posted a goblog entry in Belchfist's Realm of MadnessApologies for any grammatical errors in this post. My crazy work schedule and my almost fanatical devotion to getting some paint on this force are leaving me incredibly drained and potentially delusional (it depends...can you see those monkeys too?). However, progress is starting to show in a satisfying way. All 10 Brutes are now equally painted (nowhere near finished but arguably tabletop standard ) and are looking pretty good. the swarm of Brutes around the Megaboss is so satisfying to see, I'm so glad they put an in-game rule to make that be appealing to people tactically. It makes sense and looks awesome, so why not!? I also slapped a little pain on my Weirdnob Shaman. I have a few ideas with this guy and I was pottering around with colour schemes for him too. I think I'm going to make him darker than the rest of the force considerably, and I may dabble with some very basic OSL on some sections. I've tried it before and it did NOT go well for me haha. I'm also a little nervy about the smoke having never painted anything like it. Anyone know of any tutorials or have any personal tips? Thanks BB
Countdown - 5 days
Belchfist Beastkiller posted a goblog entry in Belchfist's Realm of MadnessSo this update is a little behind! The photos attached are actually old now and behind where I'm at. The goalposts keep shifting on this task and I now think it's as follows: -finish 10 Brutes (to better than tabletop standard) -finish 10 ardboyz -finish Shaman anything else is a bonus!
Countdown - 9 days
Belchfist Beastkiller posted a goblog entry in Belchfist's Realm of MadnessSo it's been some time since I've had a reason to sit down and paint, but one has finally shown it's ugly head! My best mate from home and gaming buddy is coming to visit in 9 days. I have a very busy schedule in that time but ...9 days to get stuff done! My lofty aim was to have every colour basecoated on all of my Ironjawz force in that time. I've swiftly realised that's unlikely. What I have so far: Megaboss: Completed Warchanter: Primed Shaman: Primed (kept apart for painting) 15 Boyz: 10 painted with basecoats on all colours, 5 unbuilt 3 Gore-Gruntas: primed 10 Brutes: 6 with basecoats and washes, 4 primed. As you can tell, my aim was ambitious. It's out of my reach, however, I'm going to pull a few all nighters to get things done. A big problem I have is that a few of my paints dried up and my order hasn't arrived so that's slowing progress and stopping me from even touching the gore-gruntas. Getting the Brutes done (passable!) is my new primary aim and if I manage it I'll be happy, seeing them behind the megaboss just looks awesome so it'll be worth it. And slapping some basecoats on the characters should make our games look better. He's running a daemons of tzeentch list based on the start collecting box. Any advice? BB
Braggoth's Beast Hammer ready
Kessler posted a goblog entry in SarvikuhordFinally my braggoth's battalion is ready. Just few weeks before new GHB release, it would be just my luck if it makes this battalion unplayable... I had this battalion idea from April and already had Frostlord on Stonehorn and four mournfangs. So I bought new mournfang set and start collecting Ironjaws (and took only gruntas from it and traded the rest for 3 additional gruntas). Since May I have been converting and painting these 10 models... Mournfangs were okay, but painting the gruntas seemed to take ages. So I converted new mournfangs to other poses, painted and started to convert/kitbash the gruntas. I wanted to have some difference between them, so I played with heads and hands, converting the gruntas was beyond my capabilities. So my gruntas have Brutes' heads and hands, ogor weapons (they are part of the Beastclaw), ardboyz heads etc. I am especially content with two weapon guy and two-handed weapon orruk. I tried to make their armor unpainted and battered/broken. After watching YouTube for tutorials how to do it I could not find any that suited for me: either the outcome was wrong or painting too complicated. So instead I covered it with leadbelcher, covered with two layers of heavy nuln oil, then highlighted with silver and finally lightly drybrushed with ironbreaker.
Braggoth's Beast Hammer progress 2
Kessler commented on Kessler's goblog entry in SarvikuhordThanks! Yep, the chaintrap is my favourite as well.
Conogre's Army 2.0
ConOgre replied to ConOgre's topic in Painting and ModellingSorry mate, very late getting to this. Yes I absolutely caught the giant bug, I completed the Son of Behemat formation so I have 5 painted and the fall down template I worked on semi-recently. Been working on a dry brush only ethereal themed skeleton army for awhile now, but as of the last couple days have shifted back and started work on ogres again... like I need more.
Farmer's Greenskins
Farmer7574 replied to Farmer7574's topic in Painting and ModellingIt's been a while! Some night goblin 'musicians' I converted for the current competition on Da Warpath: I've entered them as musicians but have decided that they'll make great additions to the squig herders instead. Here's the before shot: Inspiration came from a few things I've seen in China. The guy on the left is holding clapper sticks: I've seen these on TV in China. The audience usually have them so they don't have to clap all the time... The guy in the centre has a singing bowl: These are used in parts of Asia to help get rid of headaches and stuff by moving the stick around the inner side of the bowl and placing on the affected body part. Of course, banging it makes a loud noise and can therefore herd squigs reasonably well. The guy on the right has a flute (which kinda looks like a blow dart come to think of it). Cheers for taking a look.
Painting Fimir
The Door Master replied to The Door Master's topic in Painting and ModellingSome work done on the metal.
Making Alternative Yhetees: video
gharwars posted a topic in Painting and ModellingHi everyone, I have put a video up on Ye Olde Battle Reps in which I show how I made some alternative Yhetee models: Making Alternative Yhetees They work out very cheap and quite easy to make. Hope you enjoy!
WiP ... what is tabletop standard?
Belchfist Beastkiller commented on Belchfist Beastkiller's goblog entry in Belchfist's Realm of MadnessHaha it sort of feels like it!!!
Huskard Stonehorn Progress!
ConOgre commented on Zolas's goblog entry in Zolas's Thunder Frost Tribe Gnoblog! New and revamped!Superb painting as usual. Looking forward to him 100% done. Cheers bud.
My orcs horde and back catalog painting efforts; WIP pictures and hobby issues. Used to be an ogre blog (RIP)
ConOgre replied to Joakim's topic in Painting and ModellingFeel free to post you kharadron on here as well
Braggoth Beast Hammer in progress
Kessler posted a goblog entry in SarvikuhordJust a small update of my Braggoth Beast Hammer progression. From the pictures the gore gruntas riders were nice, but mounts' pose was too relaxed. I wanted to make gore grunta mounts a bit more dynamic, like I did with mournfangs, but it is VERY hard to convert these models. Therefore I settled with grunta riders instead, giving one Brute's left hand and other mournfangs leader weapon and changing their head position a bit. I really like the one with two weapons myself. Here's the idea I wanted to make one of them: And the final result:
maneaters and friends
Sharkbelly replied to Charlemagne's topic in Painting and ModellingThat slayer maneater is great!
Mournfang conversion WIP
Kessler posted a goblog entry in SarvikuhordI'm in the process of making a Braggoth Hammer battalion. I already had 4 mournfangs, so I wanted to make next models a bit different to get some variety. Currently I have 3 gore gruntas, but when I get the other 3, I'll make something similar with them. If the result turns out okay. I want to make some of them in rearing position, although repositioning their legs is much harder than it seemed. But repositioning the riders is even more difficult, because if a mount rears you lean forward. And I cannot turn them so, their gutplate gets in the way. I haven't found a solution for that yet. Otherwise I just kitbashed a lot: saddles and weapons from Stonehorn, something from gore gruntas etc.
More Huskard Stonehorn progress.
Zolas posted a goblog entry in Zolas's Thunder Frost Tribe Gnoblog! New and revamped!So some more pics of my Huskard on stonehorn. The reins and Blood vulture are finished and Huskard himself nearly there too. Only leaving the saddle mainly and a base to acquire and sort out. Hope you like him Hope you enjoy the pictures. Kind regards Zolas.
Progress Report 5/7/17 - 52 Minis week 18
Randroid posted a goblog entry in Drinkin' and Modelin' - Gaming and BeerFirst week without classes! Yah! Spent it doing some work around the yard, playing some games with folks, and playing music. Oh and I got these Preservers for This Is Not A Test painted up too. These are some grunts. They will likely get torn apart by mutants, cannibals, or other thrifty wasteland survivors. But at least they will do it in style!! Here we have the leaders of the warband - two of them in Power Armor. Getting things handled!


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02:31:30 pm
02:31:30 pm
What Triggers Plantar Fasciitis And Ways To Cure It
Plantar fasciitis is one of the most common causes of heel pain. It involves pain and inflammation of a thick band of tissue, called the plantar fascia, that runs across the bottom of your foot and connects your heel bone to your toes. Plantar fasciitis commonly causes stabbing pain that usually occurs with your very first steps in the morning. Once your foot limbers up, the pain of plantar fasciitis normally decreases, but it may return after long periods of standing or after getting up from a seated position. Plantar fasciitis is particularly common in runners. In addition, people who are overweight and those who wear shoes with inadequate support are at risk of plantar fasciitis.
Training on improper, hard and/or irregular surfaces as well as excessive track work in spiked shoes, or steep hill running, can stress the plantar fascia past its limits of elasticity, leading to injury. Finally, failure in the early season to warm up gradually gives the athlete insufficient time for the structures of the foot to re-acclimate and return to a proper fitness level for intensive exercise. Such unprepared and repeated trauma causes microscopic tearing, which may only be detected once full-blown plantar fasciitis and accompanying pain and debilitation have resulted. If the level of damage to the plantar fascia is significant, an inflammatory reaction of the heel bone can produce spike-like projections of new bone, known as heel spurs. Indeed, plantar fasciitis has occasionally been refereed to as heel spur syndrome, though such spurs are not the cause of the initial pain but are instead a further symptom of the problem. While such spurs are sometimes painless, in other cases they cause pain or disability in the athlete, and surgical intervention to remove them may be required. A dull, intermittent pain in the heel is typical, sometimes progressing to a sharp, sustained discomfort. Commonly, pain is worse in the morning or after sitting, later decreasing as the patient begins walking, though standing or walking for long periods usually brings renewal of the pain.
Patients with plantar fasciitis typically experience pain underneath the heel and along the inner sole of the foot. In less severe cases, patients may only experience an ache or stiffness in the plantar fascia or heel that increases with rest (typically at night or first thing in the morning) following activities which place stress on the plantar fascia. These activities typically include standing, walking or running excessively (especially up hills, on uneven surfaces or in poor footwear such as thongs), jumping, hopping and general weight bearing activity. The pain associated with this condition may also warm up with activity in the initial stages of injury. As the condition progresses, patients may experience symptoms that increase during sport or activity, affecting performance. In severe cases, patients may walk with a limp or be unable to weight bear on the affected leg. Patients with this condition may also experience swelling, tenderness on firmly touching the plantar fascia (often on a specific spot on the inner aspect of the heel) and sometimes pain on performing a plantar fascia stretch.
Plantar fasciitis is usually diagnosed by a health care provider after consideration of a person's presenting history, risk factors, and clinical examination. Tenderness to palpation along the inner aspect of the heel bone on the sole of the foot may be elicited during the physical examination. The foot may have limited dorsiflexion due to tightness of the calf muscles or the Achilles tendon. Dorsiflexion of the foot may elicit the pain due to stretching of the plantar fascia with this motion. Diagnostic imaging studies are not usually needed to diagnose plantar fasciitis. However, in certain cases a physician may decide imaging studies (such as X-rays, diagnostic ultrasound or MRI) are warranted to rule out other serious causes of foot pain. Bilateral heel pain or heel pain in the context of a systemic illness may indicate a need for a more in-depth diagnostic investigation. Lateral view x-rays of the ankle are the recommended first-line imaging modality to assess for other causes of heel pain such as stress fractures or bone spur development. Plantar fascia aponeurosis thickening at the heel greater than 5 millimeters as demonstrated by ultrasound is consistent with a diagnosis of plantar fasciitis. An incidental finding associated with this condition is a heel spur, a small bony calcification on the calcaneus (heel bone), which can be found in up to 50% of those with plantar fasciitis. In such cases, it is the underlying plantar fasciitis that produces the heel pain, and not the spur itself. The condition is responsible for the creation of the spur though the clinical significance of heel spurs in plantar fasciitis remains unclear.
Non Surgical Treatment
If conservative treatments fail, and the symptoms of plantar fasciitis have not been relieved, the doctor may recommend one of the following treatments. Cortisone, or corticosteroids, is medications that reduce inflammation. Cortisone is usually mixed with local anesthetics and injected into the plantar fascia where it attaches to the heel bone. In many cases this reduces the inflammation present and allows the plantar fascia to begin healing. Local injections of corticosteroids may provide temporary or permanent relief. Recurrence of symptoms may be lessened by combining steroid injections with other forms of treatment such as orthotics, changes in shoe gear, weight loss, stretching exercises, and rest. Repeated cortisone injections may result in rupture of the plantar fascia, thinning of the heel's fat pad, and other tissue changes. Extracorporeal Shock Wave Therapy (ESWT) devices generate pulses of high-pressure sound that travel through the skin. For reasons that are not fully understood, soft tissue and bone that are subjected to these pulses of high-pressure energy heal back stronger. There is both a high-energy and low-energy form of ESWT; and both forms of shock wave therapy can be used in the treatment of plantar fasciitis. Research studies indicate ESWT is a safe and effective treatment option for plantar fasciitis. The recovery period is shorter than traditional invasive surgery and the procedure eliminates many of the risks associated with traditional surgery.
Surgical Treatment
In very rare cases plantar fascia surgery is suggested, as a last resort. In this case the surgeon makes an incision into the ligament, partially cutting the plantar fascia to release it. If a heel spur is present, the surgeon will remove it. Plantar Fasciitis surgery should always be considered the last resort when all the conventional treatment methods have failed to succeed. Endoscopic plantar fasciotomy (EPF) is a form of surgery whereby two incisions are made around the heel and the ligament is being detached from the heel bone allowing the new ligament to develop in the same place. In some cases the surgeon may decide to remove the heel spur itself, if present. Just like any type of surgery, Plantar Fascia surgery comes with certain risks and side effects. For example, the arch of the foot may drop and become weak. Wearing an arch support after surgery is therefore recommended. Heel spur surgeries may also do some damage to veins and arteries of your foot that allow blood supply in the area. This will increase the time of recovery.
More than with most sports injuries, a little bit of prevention can go a long way toward keeping you free from plantar fasciitis. Here are some tips to follow. Wear supportive shoes that fit you well. When your shoes start to show wear and can no longer give your feet the support they need, it's time to get a new pair. Runners should stop using their old shoes after about 500 miles of use. Have a trained professional at a specialty running store help you find the right pair for your foot type, and then keep your shoes tied and snug when you wear them. Stay in good shape. By keeping your weight in check, you'll reduce the amount of stress on your feet. Stretch your calves and feet before you exercise or play a sport. Ask an athletic trainer or sports medicine specialist to show you some dynamic stretching exercises. Start any new activity or exercise slowly and increase the duration and intensity of the activity gradually. Don't go out and try to run 10 miles the first time you go for a jog. Build up to that level of exercise gradually. Talk to your doctor about getting heel pads, custom shoe inserts, or orthotics to put in your shoes. Foot supports can help cushion your feet and distribute your weight more evenly. This is especially true for people with high arches or flat feet. Your doctor will be able to tell you if shoe inserts and supports might lower your chances of heel injury.


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Wimbledon day 9 recap: withdrawals and Federer- View: 11984 by Lorenzo Ciotti
Roger Federer is the last Fab Four remaining at Wimbledon 2017. Andy Murray was defeated in five sets by Sam Querrey, while Novak Djokovic withdrew in the second set of the match against Tomas Berdych, for an arm problem.
The last semi-finalist is Marin Cilic. Karolina Pliskova is the new women's world no. 1. Here are her first statements: "Being the number one is a great responsibility for me. I am aware of this and I promise I will do my best to not disappoint.
I hope I will be successful, and I would like to thank my family once again. My team and the people closest to me. Without you I would not be where I am." Toni Nadal against Wimbledon: "Wimbledon wants to be the best tournament in the world, but sometimes it does like a little tournaments, favoring other tennis players more than it can.
At Roland Garros for example, Nadal is almost always the favorite but he does not always play on the Central Court. But this is not an excuse and is not the right time to talk about it." Justine Henin talked about Serena Williams: "We could have so many surprises when Serena comes back after having a son, of course, it will not be easy, but when she wants something, she usually does it.
I'm very curious, I can not wait to see her. It can certainly be done, maybe she is the only one that can do it. " Tomorrow the two semi-finals of women's singles. ALSO READ: Wimbledon Day 8 recap: rain, number one and - - .


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Day Nursery Manager/ Quality Manager
Our client is looking for a manager who is up for a challenge, to run a very busy day nursery. This isn't just any managers role. Their head office will take on loads of the boring administration stuff and HR support. The finance team will do a lot of those bits as well. Leaving you more time to work with the children and coach staff.
• Have you got exceptional childcare skills and knowledge?
• Do you have the ability and experience to lead and inspire a team of practitioners to go the extra mile?
• A minimum of a Level 3 in Early Years with 3 years post qualification experience with 1 year managerial experience in a similar environment?
• How good is your knowledge of health and safety?
• When the dreaded OFSTED call comes will your knowledge stand up to the inspection?
• Can you organise yourself and others, without getting in a tizz?
• Does the idea of deadlines fill you with dread or excitement?
In return for being all of the above and more, they will offer you a great nursery in a nice location to put your own stamp on. You'll receive good support (and a bit of sarcasm) from senior managers. Bonuses are also offered based on KPI basis
Salary: £22,000 per Annum
Please apply online for this Day Nursery Manager /Quality manager role with your CV and covering letter.
Please check your email for confirmation that your application has been received and to follow further instructions if applicable.


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On wall TV with Corian® frame, this serie is very easy to install on your wall.
Hanging in an elegant way,
this range of TV benefits a Corian® frame, aesthetically material, easy to clean.
On wall TV all integrated without ventilation | Technological upgrading** | Possible customization
- Easy install
- Waterproof television sets for bathroom or spa
- Latest generation flat screen
- Waterproof remote control
- Television sets complied with the harmony and ambience
- Use of top-of-the-range materials (glass, aluminium, Corian)
- Possibility custom built models (colour, size, material…)
- Cage fireproof
Standard colour of Corian® frame :
List of available colours of Corian® frame :
Available sizes
Included functions
RS232 control / IP control (option) :
- Control of the main television's functions
- Volume control by direct value
- Backlight control (on or off)
- Blocking function of the remote control
- Reading of the functions status of the TV
Infra-red relay 38 kHz :
- Control of devices deported through the TV
- Can be connected to a flasher at the rear of the TV in order to relay the emitted signal at the front of the TV
- Example of use : control of a DVD player hidden in a cabinet
Distinct ON/OFF signals (IR) :
- Simplification of programming with two separate infra-red signals to turn on and turn off the television
- Presence on the remote control of 2 buttons for the 2 signals
Customization (options)
Customized glass size
Infra-red deport
- Infra-red control of the television set from the rear
- Two separate signals ON and OFF
IP Control
Transducers :
Speaker system located at the rear of the mirror (requires a specific size glass)
*jusqu'au 55¨, **selon les évolutions des produits AGATH


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Smart people fear Artificial Intelligence. I should too!
First Stephen Hawking warns us of the dangers of artificial intelligence:
He told the BBC:"The development of full artificial intelligence could spell the end of the human race."
Then Elon Musk, of PayPal, Tesla and SpaceX fame, makes similar statements:
"I think we should be very careful about artificial intelligence. If I had to guess at what our biggest existential threat is, it's probably that. So we need to be very careful," said Musk. "I'm increasingly inclined to think that there should be some regulatory oversight, maybe at the national and international level, just to make sure that we don't do something very foolish."
Now, Bill Gates, billionaire extraordinaire and humanitarian comes out basically saying the same thing on his 3rd AMA on Reddit.
I am in the camp that is concerned about super intelligence. First the machines will do a lot of jobs for us and not be super intelligent. That should be positive if we manage it well. A few decades after that though the intelligence is strong enough to be a concern. I agree with Elon Musk and some others on this and don't understand why some people are not concerned.
Ok guys. Stop. You are seriously freaking me out. You can't be pioneers in science, computer programming and the web and just lay this out for us like that. Give us mere mortals a solution. A glimmer of hope. Isaac Asimov's laws of robotics anyone?


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New York, NY, US
I'm an Australian Junior Architect and have recently moved to NY. I graduated in 2016 from the University of Sydney with a bachelor of design in Architecture and bachelor of Civil Engineering with 1st class honours.
I like
collaborative architecture
affordable architecture
fun architecture
music and architecture
film and architecture
During Uni I worked for a small architecture practice on residential projects. In 2015 I participated in Sydney's MADE Scholarship program, where I spent 2 months in Copenhagen collaborating with a multidisciplinary team of architects, designers and engineers at the firm COBE.
The past year I have worked on 2 films - Alien: Covenant, and Pacific Rim: Uprising. As a set designer I worked on the design, pre-visualisation, and drafting of sets. This included on-site experience to work out the construction of sets, and collaboration with a range of disciplines - set dec, props, construction, carpenters, welders, sculptors, sfx, prac lx, vfx, manufacturers.
Maelstrom Productions, Sydney, AU, Set Designer
Alien: Covenant, Sydney, AU, Set Designer
Kieran McInerney Architects, Sydney, AU, Architectural Assistant
Arup, Sydney, AU, Summer Intern
The University of Sydney, Sydney, AU, BArch, Bachelor of Design in Architecture
The University of Sydney, Sydney, AU, Bachelors, Bachelor of Engineering Hons I (Civil)
Resene Rising Star, 1st Place
Winner of the Resene Total Colour Rising Star Student Award for the project "Bridge with Coffee and Karaoke".
"In this project, the power of colour stimulates conversation. The colour adds an informality and liveliness to the structure. The contrast between intimate spaces and extroverted spaces is emphasised through the use of colour. Neutral colours and vibrant colours chosen individually strengthen the juxtaposition of activities on the bridge. Dark colours contrast and accentuate the lighting to form cosy and intimate spaces.
The colours are intrinsic to the characterisation of intimate and extroverted spaces."
MADE by the Sydney Opera House, Scholarship
MADE by the Opera House, or Multidisciplinary Australian Danish Exchange, is an extra-curricular program offered to Australian and Danish students of architecture, engineering and design (in the built environment).
MADE by the Opera House was established in honour of the Opera House's 40th Anniversary celebrations in October 2013 and will run for 10 years to the 50th Anniversary in 2023. Each year, five students from a NSW university and five students from a Danish tertiary institution will participate in the program in Denmark and Australia respectively.
The students will form a multidisciplinary team to collaborate on a six-week project, developed by the MADE by the Opera House program partners and aligned with the Utzon Design Principles.


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These are NOT the genuine bags. They are however just as good.
The only real difference between this bag and the genuine one is the price!
This bag has the same plastic collar as the genuine bag and has nearly the same filtration specs.
Package includes 5 Bags and 1 pre-motor filter and 1 output side filter.
This is the imitation Miele Intensive Clean vacuum bags plus Dust Compartment & Super Air Clean Filters (Type F, J and M bags). This bags fits Miele vacuum models S246i-S256i, S290, S291 Red Star, White Star, S314 Deluxe, Ambiente S334i, Galaxy models S300i-S356i, Solaris, SolarisTurbo Plus, Solaris Electro Plus, Silver Moon, Platinum models S4000-S4999, S4210 Carina, S4210 Capella, S4210 Antares, S4210 Sirius, S4212 Neptune, S4282 Healthy Clean, S4580 Luna, S4780 Orion, S301 Midsize Canister, S312 Midsize Canister, S314 Midsize Canister Red Star, White Star, S316 Cat & Dog, S318 Medivac, S318 Bahama Blue, S324, S326, S334 Ambiente, S336 Blue Magic, S344 Platinum, S514 Solaris, S516 Cat & Dog, S518 Medivac, S524 Deluxe Midsize, S524 Mercury, Crystal, S528 Filtration Guard, S538 Monte Verde, S544 Artico, 548 Aluminium, Champagne & Exclusive, S558 Silver Moon, S558 Red Velvet, Titan and Polaris.
Also fits the new Miele s4 Galaxy Models (s4210).
These Miele IntensiveClean Plus bags are an improved version of the former Miele IntensiveClean bags #055889200
Also known as Miele FJM, F J M (F,J,M), OEM Part #05588921, Miele M50 (M 50)
OEM Part #SF-AH 30, AH30, or HA30. This is an AFTER-MARKET (Generic) Miele HEPA Filter for the Miele s300 - s600 Series Canister vacuum cleaners.
This filter will fit Miele s300, s400, s500, s600 Series models. This filter also fits the S2000, S7000, Classic and Dynamic Series models. The H.E.P.A. (High-Efficiency Particulate Air) filter captures and retains tiny, lung-damaging particles (including dust mite feces and pollen). This filter also has an activated charcoal filter (GAC) for absorbing odors. This Miele filter is rated to trap 99.99% of all particles as small as 0.3 of a micron. Please note: We have extensively tested* this filter and we feel that this filter performs AS WELL as the genuine filter, but at almost half the price. About the only thing we do not like is the fact that the recommendation from the manufacture is to change these every 6-8 months. NOTE: Sometimes this filter has a Black or White frame instead of the Blue frame. *Tested using the IQAIR Particle Scanner after 6 weeks (12 hours) of running. This filter fits the Miele S2 and S7 models, Miele White Star, Red Star, S314 Deluxe, S300i - S356i and S400i - S456i Series vacuum models. Solaris, SolarisTurbo Plus, Solaris Electro Plus, Silver and Blue Moons, Platinum, Aluminium and vacuum models S500-S558. S700-7999 and S8581. All Miele models that start with s5xx (s500, s501i, s512, s512i, s544) S301 Midsize Canister
S312 Midsize Canister
S312 White Star
S312 Red Star
S314 Midsize Royal Blue
S314 Red Star
S314 White Star
S316 Cat & Dog
S318 Medivac
S318 Bahama Blue
S334 Ambiente
S336 Blue Magic
S344 Platinum
S401 Fullsize
S428 Allergy Control Vac
S434 White Pearl
S438 Allergy Control
S444 White Pearl
S514 Solaris Yellow
S514 Solaris Turbo
S514 Solaris Electro
S516 Cat & Dog
S518 Medivac
S524 Deluxe Midsize
S524 Mercury
S524 Crystal
S528 Filtration Guard
S538 Monte Verde
S544 Artico
S548 Aluminium
S548 Champagne
S558 Silver Moon
S558 Red Velvet
S624 Deluxe Fullsize
S658 Blue Moon
S2120 Olympus
S2120 Delphi
S2180 Titan
S7 Bolero
S7 Calypso
S7 Jazz
S7 Salsa
S7 Tango Fits 300-600 Series, fits S2 Galaxy Canisters, fits Miele S7 uprights. OEM Part #04854915, SFAH30
OEM Part #SF-HA50, SF-AH 50. Fits the Miele Galaxy Series Canister Vacuum (S4 Galaxy Series) OEM Part# AF-AH 50, 05996881, AH-5 This is a REPLACEMENT Filter Miele's new design HEPA HA50 AirClean filter is designed for S4000, S5000, S6000 and S8000 series canister vacuums. Thisfilter fits the following Miele vacuum cleaner models:4210, S4212, S4282, S4580, S4582, S4780, S5210, S5211, S5280, S5281, S5380, S5381, S5481, S5580, S5981, S6270, S6290, S8380, S8390, S8390C, S8590, S8590M, S8890. This exhaust filter combines a Certified HEPA Filter with a thin layer of Activated Charcoal to provide both HEPA filtration and effective odor control. S4210 Galaxy Carina Canisters
S4210 Galaxy Antares Canisters
S4210 Galaxy Capella Canisters
S4210 Galaxy Sirius Canisters
S4580 Galaxy Luna Canisters
S4780 Galaxy Orion Canisters
S5210 Ariel Canister
S5280 Pisces Canister
S5280 Callisto Canister
S5380 Gemini Canister
S5580 Aquarius Canister
S5980 Capricorn Canister This filter should be replaced every 12 months with typical household use.
This is highly recommended for those who have dust related allergies or asthma. AH50, AH-50
This is the Miele Type U Vacuum Bags for the S7 series upright vacuum cleaners. 5.45 quart vacuum cleaner bags and includes 5 Dustbags 1 motor Filter 1 Air Clean Filter. ST-U HyClean
OEM Part #02046318, 04535372. These are the genuine Miele Paper Bags & Filters. Each box contains 5 double layer paper bags, 1 electrostatic secondary filter and 1 Super Air Clean exhaust filter. For use in Miele S200 series fullsize canisters and power teams. Fits Miele vacuum models S227-S240, S269i-S282i
OEM Part #05588951, MIR-1442. Miele Style K Bags. This bag fits the Miele S143, S147, S148, S157, and all S140 Series Models: S143-S147-S148-S157. There are 5 bags, 1 Dust Compartment Filter, & 1 Air Clean Filter.
This bag fits the Miele S125 - S138 There are 5 bags and 1 filter in each box.
Copyright © 1987-2017 VACSEW.COM


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Guide your gang of fleas through the levels, air water, and all types of clever fun.
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