text: Hello, I tend to get very quick "blips" in my sound when viewing dvds & tv. They are just interuptions for a split second, and then the sound returns to normal. The frequency of these vary, anywhere from every couple of minutes to once or twice a day. I do notice them much more often when watching satellite vs. DVDs. I'm assuming I need a better surge protector or some type of power conditior. I'm currently using a cheap $29 surge prt. from best buy. I have my TV (50in DLP), Receiver, DVD player, & PS2 connected through this protector. I've read up on the use of surge protectors & conditiors and understand the need to upgrade my current equipment. Any thoughts on what would be the best way to fix this?? (also, not sure if there would have been a better area to post this or not)


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Co-developed by NVIDIA and the robotics department at California Polytechnic State University, 'Jet' is a smart, autonomous robot based on the NVIDIA Jetson embedded development platform utilizing Servocity Acotobotics components. Jet's brain is built around the NVIDIA Tegra SoC and uses the same NVIDIA computing cores designed into supercomputers. This gives Jet compute-intensive computer vision, artificial intelligence (AI), and self-driving capabilities in a low-cost package.
Schunk SVH
The anthropomorphic SCHUNK 5-finger hand grips nearly as perfectly as the human hand. Due to the moving parts with a total of nine drives, various gripping operations can be executed with high sensitivity. Elastic gripping surfaces ensure a reliable grip on objects.
ASIMoV Robotics has launched a new series of multi-purpose mobile platforms useful for indoor and outdoor applications with unique omni-directional mobility and unmatched payload capabilities. X-Terrabot's software system is written entirely in ROS.
Intel Euclid
The Intel® Euclid™ Development Kit features the integration of Intel® RealSense™ depth camera technology, a motion camera, and an Intel® Atom™ x7-Z8700 Quad core CPU to produce a compact and sleek all-in-one computer and depth camera. The Intel® Euclid™ Development Kit is designed to be operable out of the box with pre-installed software including an Ubuntu® operating system.
THOR (Tactical Hazardous Operations Robot) is an affordable, full size humanoid robot platform with advanced computational power, sophisticated sensors, high payload capacity, and dynamic motion abilities to enable many exciting researches and educational activities.
REEM, the humanoid service robot created by PAL Robotics, can be used for several purposes. Thanks to its autonomous navigation system, its user-friendly touchscreen, and its voice and face recognition system, REEM can find its way in various surroundings and help or entertain people in most public environments.
REEM-C is the latest commercial humanoid robot of PAL Robotics. REEM-C is an adult size humanoid (165 cm), and it has 44 degrees of freedom, two i7 computers, force/torque and range finders on each feet, stereo camera, 4 microphones, and other devices that make REEM-C one of the best equipped research platforms today.
Innok Heros
Innok Heros is a modular outdoor all-terrain robot platform available in 2 or 4 wheel drive configurations. Due to its modular construction, it can be easily modified to suit lots of different agricultural, logistics, industrial and research applications.
Erle-copter is a Linux-based drone that uses the award winning APM:Copter autopilot software. It's capable of the different flight modes and ideal for outdoor operations. It has been designed for an extended flight time and it can carry a takeoff weight of about 2 kilograms.

subset: commoncrawl


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Queen Bee Develops From Larvae Chosen By Worker Bees And Are Specifically Fed To Become Sexually Mature.
Fidget | Inflatable Lounge | iPhone | Lego | Nintendo | PlayStation | Rocket Copters | xBox
The queen bee is described as the adult mated female that lives inside the hive or honey bee colony. She is the mother of most of the bees in the hive. The queen develops from larvae chosen by worker bees and are specifically fed to become sexually mature. There is only 1 adult mated queen bee present in a hive. Other dominant reproductive females in a eusocial bee colony may also be referred to as queen bees.
The queen bee abdomen is significantly longer compared to other worker bees. However, beekeepers can still have some difficulty locating the queen in a hive of 60,000 to 80,000 bees. Some queens are marked with paint on the thorax for quick identification. Beekeepers mate and raise queen bees in different ways. Some of the known approaches are the mating yard, grafting, the Jenter kit and artificial insemination.
The Workers
A worker bee is described as a female eusocial bee that does not have the complete reproductive capacity of the colony's queen bee. Some of the functions of the workers include maintaining uniformity in the hive temperature, especially in the brood area. Workers gather pollen via the pollen baskets located on their hind legs and carry these back to feed the growing brood.
Workers strive to keep the hive temperature at about 34.4 degrees C. If the hive gets too hot, workers gather water and spread it around as well as fan the air using their wings. They can gather together to produce extra heat if the temperature drops. Worker bees never reproduce because they are infertile. These are still considered genetically female. A larva can become a queen or a worker, depending on the type of food give after the initial 3 days of larval form.
The Drones
Drones are described as male honey bees. These develop from eggs that are not fertilized. The main function of drones is to prepare to fertilize the ready queen. Mating usually occurs near or inside drone areas. Drones do not usually mate with a virgin queen belonging to the same hive because queens tend to move from one hive to another. Mating occurs during flight. The drones can manage well because of their big eyes. The drone, after successful mating, usually dies because the penis and related abdominal tissues are torn from the body during intercourse.
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STORMTRACK WEATHER ALERT: Cold Front Will Drop Temperatures Big Time In El Paso [AUDIO]
Just when you got all comfy with your shorts and tank tops and air conditioning, Mother Nature decided to show us all who's boss with a late spring cold front!
Just when you got all comfy with your shorts and tank tops and air conditioning, Mother Nature decided to show us all who's boss with a late spring cold front!
Patty Campos won't be able to handle JT when she sees him live in concert.
Sadly, Matt Groening's long-running cartoon 'Futurama' was canceled earlier this week after seven seasons and 140 episodes on two different networks. Yes, we'll miss Fry, Leela and the rest of the crew, but we'll miss Bender, the acerbic, cigar-chomping robot, the most. But it's not all bad news -- Bender has rightfully earned himself a place among the most memorable robots in pop culture.
If you grew up in the late '80s and early '90s, chances are you remember 'DuckTales.' The animated adventures of the ridiculously wealthy Scrooge McDuck and his nephews Huey, Dewey and Louie were Disney's first big TV hit in decades, and they made sure the show and its characters were everywhere...
No DeLorean needed…
We couldn't wait to leave our teen years behind, but these movie and TV actors played kids when they were in their 20s and even older. Some of them had no problem slipping into a role several years their junior, but others were -- how can we put this? -- less convincing.
Here's a different take on a current KISS hit. Good luck singing this song the normal way ever again!
El Paso spring weather is really predictable. A couple of nice days, maybe a week of sunny, mild temperatures that lure you outside with pretty little plants and flowers, and then BAAAMMM, a 2 day stretch of 40 - 60mph winds!
Luckily I had troubling sleeping last night and was able to see Justin Timberlake and Jimmy Fallon perform a unique version of "SexyBack" on Fallon's late night show. Even a really ugly suit still looks good on Mr. Timberlake!
I've got dinner in the oven, a big glass of iced tea, and my favorite tv watching blanket - I am soooooo ready for a full night of 'History Channel' goodness!
I love Friends! Still makes me laugh after seeing reruns. My favorite is coming by bloopers I've never seen! Check this one out.
Make sure to set the DVR this and next Saturday as the SNL will for sure be classics!


text: (Photo Credit: Melissa Majchrzak/NBAE via Getty Images) Meltsdown Is James Harden a super-star? Are the Rockets real contenders? After the first half last night it seems like those are more legitimate questions than before. Mike MeltserMIKE MELTSER What I do for 610: Co-host Morning show with Seth Payne. Previously hosted 10-11am hour and worked as the update anchor for Vandermeer and Lopez. I initially came here as the afternoon update anchor. Age, birthday: March 14 ...More from Mike MeltserComments Leave a Reply Cancel reply Enter your comment here... Please log in using one of these methods to post your comment: Email (required) (Address never made public) Name (required) Website You are commenting using your Twitter account. ( Log Out / Change ) You are commenting using your Facebook account. ( Log Out / Change ) You are commenting using your Google+ account. ( Log Out / Change ) Cancel Connecting to %s Notify me of new comments via email. Notify me of new posts via email.


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A high-end development requires a landscape to match, but achieving a truly beautiful landscape in a very limited space takes creativity and innovation. The developers of the new Amica at London retirement community were faced with just such a challenge as they began construction on a new facility and grounds in 2010.
The area behind the development was designed to have a lawn and garden landscape that could be enjoyed by residents. However, a steep slope at the back property line severely limited space, while a storm water drainage channel cut right through the middle of the site. The goal of the project was to create an aesthetic design for the landscape that incorporated the drainage channel while maximizing usable space.
To achieve this goal, the first step was finding a way to stabilize the bank in an aesthetic way. To provide enough space for the yard, a wall needed to be built directly on the property line. However, a conservation area was adjacent to the property, making a geogrid-reinforced or tiered wall impossible.
Engineers from Aecom London Inc. considered several different options including a cast-in-place concrete wall before designing a 14 ft. (~4 m) high sheet pile wall to retain the soil. To achieve the aesthetic finish the project required, Amica chose Rosetta Hardscapes' Outcropping Collection walls from Brown's Concrete to face the sheet pile wall.
The Rosetta Outcropping Collection is a structural retaining wall system that accurately achieves the look and feel of natural outcropping stone. By creating Rosetta using wet cast concrete, walls achieve a natural look unattainable by dry cast products. Rosetta's Outcropping Collection uses 12 unique size units with 24 unique stone textures. Dimensions vary from 24 in. (.6 m) to 72 in. (1.8 m) wide and from 6 in. (15 cm) to 24 in. (.6 m) tall.
These relatively large dimensions give walls a natural, believable finish. Outcropping walls can be engineered and reinforced to create tall, structural retaining walls but in this application, the designers chose Rosetta to act as an aesthetic face for the structural sheet pile retaining wall because there simply was not enough room to build a reinforced Outcropping wall on site.
The installation of the Rosetta portion of the project progressed very quickly. Groundmasters, Inc. had scheduled 2-3 weeks to install the project, but ended up completing the installation in only six working days.
"It was very tight quarters. It was over a storm water channel so it all had to be put in with a crane," explained Gary Lima, owner of Groundmasters, Inc. "The product is pretty easy to put in, and we installed it on a concrete leveling pad so we didn't have to mess around with preparing a base. It's one of those jobs that just went really well."
In ordinary Outcropping walls, shear heels on the back of each block provide a mechanical connection between units, but for this wall, some of the shear heels needed to be removed to achieve the necessary wall batter. The lifting hook on the back of the Outcropping block was then fastened to the sheet pile wall using re-bar. This is analogous to ties being used to secure brick to a building structure. The end result was a truly unique engineering feat.
The Rosetta Outcropping Collection allowed engineers to create a beautiful, unique wall that the residents of Amica enjoy on a daily basis. To learn more about the complete line of hardscape solutions from Rosetta, visit www.discoverrosetta.com today!


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Kai Suan Psychiatric Hospital
Kai Suan Psychiatric Hospital
Lee T.-W.,Chang Gung Memorial Hospital |
Lee T.-W.,Chang Gung University |
Yu Y.W.-Y.,Yus Psychiatric Clinic |
Chen M.-C.,Kai Suan Psychiatric Hospital |
Chen T.-J.,E DA Hospital
Journal of Affective Disorders | Year: 2011
Background: Diagnosis and treatment rely on symptom criteria in modern psychiatry. However, the cortical mechanisms of symptomatology in major depressive disorder (MDD) are still not clear. This study examined neural correlates of symptom clusters of MDD by electroencephalography (EEG). Methods: Resting state eye-closed EEG signals were recorded in 196 depressive patients. Quantitative EEG (qEEG) of regional power, coherence and power series correlation across delta, theta, alpha and beta frequencies were used to correlate with overall depression severity evaluated by the Hamilton Depression Rating Scale (HDRS). Further, statistical comparisons between patients with high vs. low qEEG indices (median-split) were undertaken regarding symptom severity of core depression, sleep, activity, psychic anxiety, somatic anxiety, and delusion. Results: None of the qEEG indices significantly correlated with overall depression severity or differentiated symptom severity of core depression, sleep, activity and psychic anxiety. A higher symptom severity of somatic anxiety was associated with higher regional power over widespread cortical regions and lower strengths at bi-temporal, temporo-parietal and fronto-parietal connections. A higher symptom severity of delusion was associated with higher regional power in the frontal and temporal regions, and lower strengths at inter-hemispheric (frontal, temporal and parietal) and fronto-temporo-parietal connections. Limitations: Our EEG recording with sampling rate of 128 Hz and 20 electrodes may provide restricted spatial and temporal precision. Conclusions: Our results suggest that cortical mechanisms play important roles in the symptom manifestation of cognitive distortion (sub-score of delusion) and somatic anxiety in MDD. Our findings further imply that psychic anxiety and somatic anxiety are distinct entities. © 2010 Elsevier B.V. All rights reserved.
Lee P.,I - Shou University |
Li P.-C.,I - Shou University |
Liu C.-H.,Kai Suan Psychiatric Hospital |
Hsieh C.-L.,National Taiwan University Hospital
Archives of Clinical Neuropsychology | Year: 2011
The Symbol Digit Modalities Test (SDMT) and Digit Vigilance Test (DVT), both well-recommended attention tests for schizophrenia, are measures of switching and sustained attention, respectively. The purpose of this study was to investigate the test-retest reliability of the two attention tests in schizophrenia. A rater administered both tests on 147 participants with schizophrenia twice at a 1-week interval. Test-retest reliability was determined through the calculation of the intra-class correlation (ICC) coefficient. We also carried out the Bland-Altman analysis, which include a scatter plot of the differences between test and retest against their mean. System biases were evaluated by use of a paired t-test. The ICC for the SDMT was 0.87 and that for the DVT was 0.83. The limits of agreement (LOAs) of the SDMT and DVT were 11.5 to -9.9 correct responses and 156.3 to -249.2 s, respectively. The mean difference scores of the SDMT and DVT were 1.5 (4.7% of the first session mean; p = .002) and -46.4 (7.6% of the first session mean; p < .001). The ICCs show that the SDMT and DVT are stable measures across assessment in different sessions in schizophrenia. However, the paired t-test indicates a practice effect, and the LOAs show large variations. Thus, the SDMT and DVT are reliable for a group of subjects but limited for individual subjects with schizophrenia in 1-week interval clinical trials. © The Author 2011. Published by Oxford University Press. All rights reserved.
Yen J.-Y.,Kaohsiung Medical University |
Chang S.-J.,Kaohsiung Medical University |
Ko C.-H.,Kaohsiung Medical University |
Yen C.-F.,Kaohsiung Medical University |
And 3 more authors.
Psychoneuroendocrinology | Year: 2010
This study aimed to: (1) evaluate food craving and high-sweet-fat food craving across the menstrual cycle; (2) compare the craving and explicit/implicit emotional response to different food; and (3) investigate the reward sensitivity among PMDD and control groups. The PMDD group without treatment history and control group were evaluated for food craving, emotional response to food, implicit attitude task to food, and responsiveness to reward both in luteal and follicular phases. A total of 59 women with PMDD and 60 controls had completed the study. The results revealed that both PMDD diagnosis and luteal phase were associated with higher body mass index. The high-sweet-fat food provoked higher craving, positive emotional, and positive implicit response more than other foods. The luteal phase contributed to higher food and high-sweet-fat food cravings. Besides, the PMDD women had higher reward sensitivity, emotional response, positive implicit attitude, and craving response to high-sweet-fat foods. Further, the rewarding sensitivity was associated with emotional response to high-sweet-fat food which was associated with high-sweet-fat food craving. These results would suggest emotional response and implicit attitude might play a role for high-sweet-fat food craving of PMDD. Further, PMDD women with higher reward sensitivity should be a target group of intervention for high-sweet-fat food craving. © 2010 Elsevier Ltd.
Wang P.-W.,Kaohsiung Medical University |
Wu H.-C.,Kai Suan Psychiatric Hospital |
Yen C.-N.,Tainan Hospital |
Yeh Y.-C.,Kaohsiung Medical University |
And 3 more authors.
American Journal of Drug and Alcohol Abuse | Year: 2012
Background: A good quality of life (QOL) is associated with successful treatment in patients with opioid dependence. Therefore, it is of clinical benefit to examine what factors can predict a change in QOL among heroin users in the course of a methadone maintenance treatment (MMT) program. Objectives: This longitudinal study aimed to examine the patterns and predictors of change in QOL among heroin users during the period of an 18-month MMT program. Methods: A total of 368 intravenous heroin users receiving MMT in southern Taiwan between 2007 and 2008 were interviewed using the Taiwan version of the Brief Version of the World Health Organization Quality of Life Instrument (WHOQOL-BREF) at baseline and after 3, 6, 9, 12, 15, and 18 months of treatment. Demographic and substance-use characteristics, severity of heroin use, HIV serostatus, criminal record, and family function data were collected during baseline interviews. Data on methadone dosage at each follow-up point and the duration of retention in the MMT program were also collected. Results: Improvement in QOL was rapid during the first 3 months after initiation of MMT and slowed beyond the 3-month point. A higher dosage of methadone predicted a better QOL. In addition, longer retention in the program may be associated with a better QOL. Conclusions: The results supported the hypothesis that, regarding QOL, heroin users can benefit rapidly and continuously from a MMT. A higher dose of methadone and longer treatment may predict improvement in QOL. Scientific significance: Efforts are needed to amend the modifiable factors related to poor QOL for heroin users in MMT programs.
Chang Y.S.,Kai Suan Psychiatric Hospital |
Wu Y.H.,Kai Suan Psychiatric Hospital |
Hsu C.Y.,Kaohsiung Medical University |
Tang S.H.,Kai Suan Psychiatric Hospital |
And 2 more authors.
Sleep Medicine | Year: 2011
Objective: A three-shift work schedule with fast rotation is common among healthcare workers in Taiwan. This study compared cognitive performance at the time of maximum fatigue (3-4 am on the last night shift of the rotation) between nurses working two, three, and four consecutive night shifts. Methods: Sixty-two nurses [mean age 26.4 (standard deviation 2.0) years] were recruited from the acute psychiatric ward and assigned at random to three groups: two, three, and four consecutive night shifts. The exclusion criteria were: current use of hypnotic drugs, regular consumption of coffee, psychiatric illness, major systemic disease, and sleep disorders. Cognitive performance was assessed using the State-Trait Anxiety Inventory, Stanford Sleepiness Scale, Wisconsin Card Sorting Test, Taiwan University Attention Test, Digit Symbol Substitution Test, and Symbol Searching Test. Results: Greater impairment of perceptual and motor ability was seen among subjects who worked two consecutive night shifts compared with those who worked four consecutive night shifts. No differences in demographic data, executive function or attention were found between the three groups. Conclusion: The main duties of nurses working night shifts at the study hospital include checking medical orders and prescriptions, which require perceptual and motor abilities. The results of this study suggested that a fast shift rotation may increase the risk of medical errors. © 2011 Elsevier B.V.
Lane H.-Y.,China Medical University at Taichung |
Lin C.-H.,Kai Suan Psychiatric Hospital |
Huang Y.-J.,China Medical University at Taichung |
Liao C.-H.,China Medical University at Taichung |
And 2 more authors.
International Journal of Neuropsychopharmacology | Year: 2010
Recent evidence indicates that enhancing N-methyl-d-aspartate (NMDA) neurotransmission with the treatment of NMDA/glycine site agonists, such as d-serine, or a glycine transporter-1 (GlyT-1) antagonist, N-methylglycine (sarcosine), can improve symptoms of schizophrenia. To compare these two novel approaches, 60 patients with chronic schizophrenia were enrolled into a 6-wk double-blind, placebo-controlled trial of add-on treatments at the reported effective dosages (2 g/d). Clinical assessments were conducted every other week. Treatment grouptreatment duration interaction analysis by multiple linear regression showed that sarcosine was superior to placebo at all four outcome measures of Positive and Negative Syndrome Scale (PANSS) total (p=0.005), Scale for the Assessment of Negative Symptoms (SANS) (p=0.021), Quality of Life (QOL) (p=0.025), and Global Assessment of Functioning (GAF) (p=0.042). However, d-serine did not differ significantly from placebo in any measure. Sarcosine treatment was better than d-serine in effect sizes for all outcome measures. Sarcosine also surpassed placebo in most of the measures of five PANSS factors and five SANS subscales. All treatments were well tolerated. These findings suggest that the GlyT-1 inhibitor is more efficacious than the NMDA/glycine site agonist in treatment for schizophrenia, including life quality and global function, at the dosages tested. Copyright © CINP 2009.
Chou F.H.C.,Kai Suan Psychiatric Hospital |
Chou F.H.C.,Meiho University |
Tsai K.-Y.,Kai Suan Psychiatric Hospital |
Su C.-Y.,I - Shou University |
And 3 more authors.
Schizophrenia Research | Year: 2011
Objective: To estimate the incidence and relative risk of developing cancer as well as the mortality rate after cancer diagnosis for patients with schizophrenia compared with the general population. Methods: Our population for this study was identified before the end of 1999. The study included 59,257 patients with schizophrenia and 178,156 age- and gender-matched individuals without schizophrenia as controls, who were selected from the 23,981,020 subjects in the National Health Insurance Research Database (NHIRD), which consists of 96% of the entire Taiwanese population. From the 2000 to 2008 NHIRD, we calculated the cancer incidence and survival time after cancer diagnosis in each of the two groups. Based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM), the cancers were divided into nine groups. Results: During the nine-year follow-up period, 1145 (1.93%) of the patients with schizophrenia and 5294 (2.97%) of the control group developed cancer. The patients with schizophrenia had a significantly lower cancer incidence than those in the control group in both the male (OR = 0.50, 95% CI, 0.46-0.55) and female (OR = 0.81, 95% CI, 0.74-0.88) populations. Patients with schizophrenia were less likely to develop cancer than individuals in the control group for every cancer type except breast and cervical/uterine cancer. After adjustment using the Cox regression model, patients with schizophrenia had an overall decreased cancer risk (adjusted hazard ratio 0.71, 95% CI, 0.66-0.76) compared to the control population. For all cancer patients, the mortality adjusted hazard ratio for patients with schizophrenia versus the control group was 1.36 (95% CI, 1.24-1.50) after adjusting for other variables. Conclusions: Although the likelihood of developing cancer among patients with schizophrenia (0.64) was less than that of the non-schizophrenia group, the mortality rate among patients with schizophrenia was higher than that of the control group. © 2011 Elsevier B.V.
Tsai K.-Y.,Kai Suan Psychiatric Hospital |
Lee C.-C.,National Yang Ming University |
Lee C.-C.,Buddhist Dalin Tzu Chi General Hospital |
Lee C.-C.,Tzu Chi University |
And 4 more authors.
Schizophrenia Research | Year: 2012
Objective: This study aimed to estimate the incidence and relative risk of stroke and post-stroke all-cause mortality in patients with schizophrenia. Methods: This study identified a study population from the National Health Insurance Research Database (NHIRD) between 1999 and 2003 that included 80,569 patients with schizophrenia and 241,707 age- and sex-matched control participants without schizophrenia. The participants were randomly selected from the 23,981,020-participant NHIRD, which consists of 96% Taiwanese participants. Participants who had experienced a stroke between 1999 and 2003 were excluded. Using data from the NHIRD between 2004 and 2008, the incidence of stroke (ICD-9-CM code 430-438) and patient survival after stroke were calculated for both groups. After adjusting for confounding risk factors, a Cox proportional-hazards model was used to compare the five-year stroke-free survival rate to the all-cause mortality rate across the two cohorts. Results: Over five years, 1380 (1.71%) patients with schizophrenia and 2954 (1.22%) controls suffered from strokes. After adjusting for demographic characteristics and comorbid medical conditions, patients with schizophrenia were 1.13 times more likely to have a stroke (95% CI = 1.05-1.22; P = 0.0006). In addition, 1039 (24%) patients who had a stroke died during the follow-up period. After adjusting for patient, physician and hospital variables, the all-cause mortality hazard ratio for patients with schizophrenia was 1.23 (95% CI = 1.06-1.41; P = 0.0052). Conclusions: During a five-year follow-up, the likelihood of developing a stroke and the all-cause mortality rate were greater among patients with schizophrenia as compared with the control group. © 2012 Elsevier B.V.
Lin C.-H.,Chang Gung University |
Lin C.-H.,China Medical University at Taichung |
Lin P.-P.,China Medical University at Taichung |
Lin C.-Y.,Tsaotun Psychiatric Center |
And 4 more authors.
Journal of Psychiatric Research | Year: 2016
Background: The cystine/glutamate antiporter system xc -, playing a critical role in the regulation of glutamate release, might be implicated in the pathogenesis of schizophrenia. This study examined whether peripheral expressions of the system xc - subunits are characteristic of schizophrenia. Methods: Expression of system xc - genes including SLC3A2 and SLC7A11 in peripheral WBCs of patients with schizophrenia and healthy individuals were measured using quantitative PCR. Both psychotropic-free and medicated patients with schizophrenia were recruited. Results: A total of 96 schizophrenia patients (48 medicated and 48 drug-free) and 96 healthy individuals were enrolled. The mRNA expression levels using the 2-δδC T Method of both SLC3A2 and SLC7A11 in WBCs of schizophrenia patients were markedly lower than that of healthy individuals (0.22 and 0.48, respectively, the mRNA expression level of normal controls was normalized to 1). There was no significant difference between medicated and drug-free patients in the mRNA expressions of both SLC3A2 and SLC7A11. The Receiver Operating Characteristics (ROC) analysis of SLC3A2 mRNA levels using δδCT values for drug-free schizophrenia patients vs. healthy controls determined an optimal cutoff value, 0.801, with high sensitivity (1.000) and modest specificity (0.694) (area under curve of ROC = 0.794). Conclusion: This is the first study indicating that the peripheral mRNA expression levels of SLC7A11 and SLC3A2 may be lower in patients with schizophrenia than healthy individuals. The finding supports the hypo-glutamatergic neurotransmission hypothesis in schizophrenia. Whether mRNA expression of system xc - subunits genes, particularly SLC3A2, could serve as a potential biomarker of schizophrenia needs further studies. © 2015 Elsevier Ltd.
Lee T.-W.,Laureate Institute for Brain Research |
Wu Y.-T.,National Yang Ming University |
Yu Y.W.-Y.,Yus Psychiatric Clinic |
Chen M.-C.,Kai Suan Psychiatric Hospital |
And 2 more authors.
Psychiatry Research - Neuroimaging | Year: 2011
Predicting treatment response in major depressive disorder (MDD) has been an important clinical issue given that the initial intent-to-treat response rate is only 50 to 60%. This study was designed to examine whether functional connectivity strengths of resting EEG could be potential biomarkers in predicting treatment response at 8. weeks of treatment. Resting state 3-min eyes-closed EEG activity was recorded at baseline and compared in 108 depressed patients. All patients were being treated with selective serotonin-reuptake inhibitors. Baseline coherence and power series correlation were compared between responders and non-responders evaluated at the 8th week by Hamilton Depression Rating Scale. Pearson correlation and receiver operating characteristic (ROC) analyses were applied to evaluate the performance of connectivity strengths in predicting/classifying treatment responses. The connectivity strengths of right fronto-temporal network at delta/theta frequencies differentiated responders and non-responders at the 8th week of treatment, such that the stronger the connectivity strengths, the poorer the treatment response. ROC analyses supported the value of these measures in classifying responders/non-responders. Our results suggest that fronto-temporal connectivity strengths could be potential biomarkers to differentiate responders and slow responders or non-responders in MDD. © 2011 Elsevier Ireland Ltd.


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With each group of artifacts we receive, Daniel and I are able to describe a little more of our spirit guides' lives. The following is a collection of our work. Daisy Fortunis
Jump to most recent entry (posted 10/28)
Chapter 1
McDoggerel is the subaltern, and what follows explains why. The name he swears he was born with is Wesley Raymond Wynne, the eldest son of a prosperous family of bankers from Schenectady, New York, but that is an outright lie. Although he does have the dress and manners of a gentleman, it is wise to remember that this is also a man who will go on to earn his living affecting the manners of a Scottish king, and a Danish prince. His talent is mimicry, learned early, not as part of a prosperous family named Wynne, but in the kitchen of the Wynne mansion, where his mother, a German immigrant, works as a scullery maid.
Chapter 2
McDoggerel is a dreamer, possessing a vivid imagination hampered only by circumstance, which is how his talent for mimicry is born. He hopes to rise by aping his betters. He practices in the shadows, following the Wynnes while remaining securely at the edges of their lives, hiding behind trees, watching as they drink tea on a broad verandah, spying as they come and go, as a butler helps them on and off with their coats, how they nod politely at servants, and coo intimately at one another; their self-approbation, their swirling politesse, bearing fraught with belonging, as if their dazzling lives will continue to dazzle indefinitely.
Chapter 3
Mr. Henry Wynne, the patriarch, rules his family stiffly and recognizes the boy's eager intelligence, often encouraging him to - "Dream big, my boy. Ours is a big country in need of big dreams." And when McDoggerel is old enough, to earn extra money to stay in high school, the young man is paid a pittance to serve them their meals, careful to flatter them because they love being flattered. In return, they offer McDoggerel their cast-off clothes and shoes and books. As Mr. Wynne is fond of telling him, "A gentleman is known primarily by three attributes, his accent, his shoes and the condition of his nails, which must never be chewed or ragged." McDoggerel never chews his again.
Chapter 4
In his younger days, when McDoggerel was still naïve enough to assume the Wynnes would continue to help him advance - he is, after all, self-taught and ambitious - but he will be proved wrong. He learns that people like the Wynnes maintain their place in society by denying him his, because if he can rise as high and quickly as they then how good does that make them? And when, after high school, McDoggerel asks for tuition to attend college, he says that after graduation he will pay it back by becoming a clerk in Wynne's bank, his request is rudely dismissed. Old Mr. Wynne offers what he considers more suitable employment as an under-butler.
Chapter 5
Stung by Wynne's insensitivity, his inability to see McDoggerel's true nature, McDoggerel, the liar becomes McDoggerel the thief. Late one night, after everyone has gone to bed, McDoggerel steals a Georgian silver tea service, as well as Mr. Wynne's clothes (two suits, one for winter, one for summer, some shirts, cravats, cufflinks, socks and shoes) and flees to New York City, where he pawns the silver for enough money to set himself up as a gentleman - which is when his talent for mimicry turns into outright lying. He becomes Wesley Raymond Wynne, a graduate of Princeton, the eldest son of the banking Wynne's of Schenectady.
Chapter 6
As Wesley R. Wynne, McDoggerel secures employment as a bond salesman on Wall Street, and he advances through hard work and ample charm that helps him maneuver through the eddies and swells of high finance. He leaves behind his simple rooming house and rents a large apartment. He is able to buy his own clothes and shoes - but one day when he is introduced to a visiting partner from the Philadelphia branch of his investment firm - a genuine Princetonian, and a friend of the real Wesley Raymond Wynne - McDoggerel is exposed as a fraud and is fired.
Chapter 7
Broke once again, McDoggerel secures a job as a haberdashery salesman in one of the new department stores that dot what is called the "Ladies Mile" on lower Madison Avenue, where he sells things he wants for himself to ladies and gentlemen with less intelligence and refinement - a disastrous situation that leads him to bouts of melancholia, his prospects, once so promising having dimmed so miserably. He lives in a rooming house, its halls reek of rancid cooking oil, and he must share his bathtub and sink with slobs and back slapping salesmen. And his melancholia leads to drink, an easy tumble when one is forced to slavishly help the spoiled decide between the merits of a blue rather than a maroon cravat by day and drown the loss of prospects at night.
Chapter 8
Blanche (birth name Anne) was born into a middle class family, in Philadelphia around 1825 (Blanche remains vainly uncertain about her birth date or any date that confirms her true age). Not genteel but aspiring to be, her father is an ambitious ship's captain, who is able to keep his family in comfortable circumstances; he sends Anne to the first female academy in Philadelphia, and makes sure that she is dressed fashionably so that she can attract a suitable mate. But a reversal of fortune in the 1840's compels the Captain to marry off the (approximately) fifteen-year old Anne to an older, debauched shipping merchant.
Chapter 9
The merchant Anne is forced to marry, Harmskite, has been married twice before, both wives having died in childbirth; the Harmskite daughters from these previous unions are older than Anne. The merchant's income and social status should have kept her in the comfort that her prospects required but Harmskite turns out to be an alcoholic who does not consistently pay his bills. When drunk, he becomes abusive, and afterwards mewls his apology, head cupped in his hands, pleading forgiveness.
Chapter 10
The household is fraught with bickering over money and possessions - Harmskite's daughters, Regina and Maude, pluck the best for themselves, with Harmskite's sniveling blessing. Finally, at Anne's insistence, when the opportunity arises for him to make a killing in the spice trade in the East Indies, Anne urges him to sail off on one of his ships, and when she does not hear from him for the next three years, she assumes he is dead. Aiding and abetting this assumption is the fact that she has fallen in love, for the first time in her life, with a handsome but penniless young drifter, named Richard Beesgrove.
Chapter 11
Anne has Harmskite declared legally dead and marries her beloved Beesgrove. Her father, whose prospects improved through his daughter's marriage to the merchant, is incensed. How can Anne sacrifice her status for a drifter? But she is besotted; Beesgrove may be a loafer, but he is an assured and active one, and he is all hers. And just when she thinks everything is perfectly settled, a year after being declared legally dead, four years after his disappearance, Harmskite returns to Philadelphia, threatening not only divorce but charges of bigamy - in other words, total ruin.
Chapter 12
In a fit of rage that Anne mistakenly thinks she can ride herd over, Richard Beesgrove rushes from her arms to track down, shoot and kill Harmskite. And he succeeds. Did he think Anne's money could save him? Beesgrove had no friends in Philadelphia. An idiot lawyer, a real estate trusts person, is ordered to defend Beesgrove, who is promptly convicted of murder and sentenced to death by hanging, with Anne convicted as an accessory. In jail, with no one to speak up for her - her father disowns her, Maude and Rachel Harmskite, the daughters, have had her disinherited - everything seems lost, her love, her life - she prays for if not deliverance then guidance, but nothing is revealed. What to do? When life has been spread before you like a trajectory leading ever-upwards, there is no easy explanation for not only failure but misery! She'd never anticipated outright misery. What to do? There must be someone or something to turn to for guidance.
Chapter 13
Wilted in a freezing jail cell, Anne considers ending her life, which teaches her a lesson; always wait out wanting to end your life for a night and a day. Because, in Anne's case, a lawyer suddenly appears to defend her. An unhappily married lawyer, as it turns out, who pointedly does not request payment in the form of cash or check. The good news is that he is also a sagacious lawyer who discovers within a day of taking the case that there is no evidence whatsoever to prove that Anne colluded with Beesgrove to murder Harmskite. She is acquitted. A lot of good it does her: the only man she has ever loved is hanged, and she is ruined because of her notoriety.
Chapter 14
Lacking financial resources to begin a new life, Anne urges her father to either help her or she will have no choice but to spread rumors about herself being kept in a hotel apartment by an unhappily married lawyer named Bernstein. Her father tells her it is all her fault that her life has fallen to such depths. He gives her money on the condition that she leaves Philadelphia, never to return.
Chapter 15
Changing her name to Blanche - just Blanche, she is thrilled by the affectation of a single name, especially a French one - she moves to New York and falls in with a slick petty thief and his gang, which is a welcome change - middle class mores and respectability have offered her very little in the way of comfort - now it is freedom she wants.
Chapter 16
In six months time, she has perfected a confidence trick that earns a decent living, called "Falling down sick," which she practices in front of a rich person's house - falling on their stairs in a dead faint. She is invariably taken in - her innocent-looking beauty is never challenged, also, her clothes are good and she knows her part; she tells her potential benefactors a tale of marriage gone horribly wrong, an alcoholic husband, a brute who beats her and usually she is rewarded with protection as well as room and board - until finally she absconds with a particularly rare painting or pearl brooch, which she fences for hard cash.
Chapter 17
She pulls off this con successfully for a year, alternating among New York, Brooklyn and Yonkers, but, frankly, like all roles, it becomes tiresome, having to work so hard to ingratiate herself with total strangers, and the New York Police have warrants circulating with her description. She is forced into early retirement, which is precisely when she finds McDoggerel - stumbling home from a bar to his rooming house on West Fourteenth Street. She follows him.
Chapter 18
McDoggerel stops to light a cigar, his one last luxury, under a street lamp, on Twelfth Street. He is too drunk to notice her, but she is close enough to see a resemblance to the great love of her life, Beesgrove, whom she misses more than she can say - which is perhaps why the resemblance seems more acute than it would in broad daylight, or on any other evening but this particular melancholy, fog drenched one. McDoggerel is Beesgrove come back to life, and as he reaches his rooming house, Blanche decides that before finally retiring it once and for all, she will play "Falling down sick" just one more time - and before she can maneuver into position, he stumbles in the street, face down into a wide inky puddle.
Chapter 19
The attraction between them being instantaneously reciprocal, Blanche and McDoggerel bond but neither is honest with the other. McD (she is fond of pet names, and shortens his) adapts his life, telling her he is a disinherited heir to a great banking fortune. Blanche tells McD about her brutal marriage, failing to mention the murder that followed it - although she is remarkably honest about her success as a confidence woman, entreating him to follow her into this canny profession. And, in short order, he perfects a con called "The Pocket Watch," which plays on his looks, charm and easy air of good breeding. He asks a gentleman for his pocket watch on the flimsiest of pretexts, telling "the mark" he'll bring it right back. Then, of course, he absconds with it - people literally hand over their prized possessions because he looks so thoroughly trustworthy. And so talented at it is he that he manages in one day to scam twenty-five of them, which are easily fenced, pocket watches being all the rage, and their lives seem set. Except for a single brush with the law ...
Chapter 20
McD mistakenly steals the pocket watch of the Chief of Police, who circulates detailed descriptions of them and they beat a hasty exit to New Jersey and points south. Along the way, Blanche shares her passion for the stage with McD, who is transformed, and soon, wherever they go, the first thing they do is attend the local theaters. Blanche confesses that she has always wanted to go on the stage. McD suggests that they already are. Haven't their confidence schemes been short plays, not scripted but certainly well-acted. And so, having already succeeded on the streets, they decide to form their own touring company - The Immortal Bard Traveling Players.
Chapter 21
They call themselves The First Couple Of The American Stage, and, traveling in grand style, they are a modest success. No one in the provinces imagines they are novices because they know no better, and also the acting style of the time did not enlist the subtlest of emotions. Blanche readily admits that during her "Come you spirits that tend on mortal thoughts, unsex me here" soliloquy from Macbeth she nearly lacerates herself nightly. But, by and large, things go well, Blanche and McD think that finally they have found their true callings. Unfortunately, with the rigors of the road, two years of endless touring, they turn their weary scenery-chewing fire on one another.
Chapter 22
After every performance, night after night, McD gives Blanche notes: "Tone it down, Blanche." Or, "Stick to the way we rehearsed!" And she counters with "I will if you stop sticking your tongue out as if you've been poisoned when you've just poisoned someone else!" And, at a particularly fractious juncture, just outside Cleveland, on a barge, with both of them venting and seething - as Blanche often does on barges, so deathly afraid of water is she - they decide it is best to part ways.
Chapter 23
Of course, on dry land, it suddenly occurs to Blanche that what they need is a foil, a third actor, someone whose acting could better frame their own: A Fallstaff for McD's Prince Hal, a Brutus for his Caesar - and suddenly, as they round a bend in the road, there sits the most handsome man, a preacher of some sort, dressed in black, clerical collar in disarray, he's weeping copiously by the side of a road. Little do they know but this man will become not only their foil, but their savior; the author of their prodigious success.
Chapter 24
His name is Elliot Asbury, the only son and grandson of country preachers, raised on bible and prayer, and when young, always in the company of his father and grandfather - his mother and grandma having died when he was a baby. On Sundays, he would make the rounds, what his father called the preaching circle, sometimes in churches, most times in the fields where the faithful would put down their hoes, unhitch their teams, to join in prayer, a stolen moment of calm. The look on their faces told stories of lives stunned by the harshness of work and sun, dreams beaten and battered, and his grandfather lifting his arms to the heavens, praying for their souls, transformed them with hope. Sometimes his father knelt with them in the fields, teaching them psalms, or leading them in song - Rock Of Ages - his voice was strong and sweet and their souls were carried on it. Sadly, Elliot Asbury understood early on that he could never be as good as his father or grandfather; that he can never follow in their footsteps, which is all they expect of him.
Chapter 25
The truth is that Elliot Asbury is too easily distracted by the intricacies of a life well lived - the path of a buzzing fly distracts him, the taste of a perfectly baked torte, a woman's becharmed, outstretched hand - he is of this world and no other, with no conception of heaven except what he can sniff and see, feel, taste - his salvation can hardly be called salvation when it resides in savories and assignations - and because of an incident involving a farmer's daughter (and not the first of such incidents unfortunately), Elliot has been dismissed from the Seminary his father and grandfather founded, where he was employed as a teacher. He has not only dishonored himself but his family. And so he has walked outside of town to weight his pockets with large rocks, to jump into the river and drown, when McD and Blanche appear.
Chapter 26
Elliot Asbury becomes The Reverend - another of Blanche's pet names. In short order McD shows The Reverend that actors and preachers aren't that much different, each reading from a time-honored text, repeated year in, year out. Blanche adds that actors are, through their work, soothing the souls of all who pay to see them. And, for many months it is paradisiacal, with The Reverend transforming the nature of their work, and McD and Blanche playing to the best houses of their careers. Because aside from his preternaturally fresh-faced looks, the Reverend has natural comic skills, with stage fright kept in abeyance with wine that McD, whom The Reverend comes to regard as a second father, supplies before each performance. But like the paradise of the good book, a snake enters the garden. The Reverend, who when drunk is prone to self-contemptuous revelation, believes that he is betraying McD, his benefactor, on two counts.
Chapter 27
When the Reverend appears on stage with McD - his entrance met with thunderous applause every evening - he turns McD's serious acting into travesty, which the audiences cannot get enough of; there, stage right, is McD intoning his alternately stoic and weepy way through any line that Shakespeare threw at Hamlet, and stage left, every night, on the cue, "or not to be," the Reverend enters - applause - and throws the pie, a cream pie, actually, a Boston cream pie, freshly baked for every performance. The Reverend thinks he is doing McD a great favor by extracting the chocolate filling from beneath the whipped cream - wouldn't it be heavier if he didn't? But McD no longer sees it that way. McD is showing signs of loathing his protégé, glaring at the Reverend with every post-soliloquy exit. Blanche is more pragmatic, she has learned how to play with the audience, and if the Reverend is getting laughs, and that is what fills seats, so be it.
Chapter 28
McD begins receiving thunderous applause on his entrances and exits. Good word about the Immortal Bard Traveling Players has spread among the outlying towns of Pennsylvania and Maryland. The audiences now sit gleefully atwitter in anticipation of the first soliloquy. They begin laughing as soon as he appears, uttering his first "To be." McD is so solidly sure of his performance he finds it hard to understand what the laughter is about. It wounds his pride. He wants to be brilliant. And if he complains about being laughed at, all Blanche has to do is point to the strong box that houses their money. The money they're taking in has never been better. At the final curtain, when McD is alone on stage with Blanche, taking bows, kissing her hand, the audience throws flowers! That is not nothing, he reminds himself. Although he knows something else is rotten in Denmark: It's the Reverend and Blanche. One night, McD stands in the wings as they play something they've cudgeled together from Twelfth Night and Macbeth, and McD notices the affinity in their glances, the inseparability of their smiles. As the Reverend exits, passing McD in the wings, McD seethes, "I know what you're up to."
Chapter 29
McD's taste of fame is only several months old, so he cannot be faulted for enjoying it blindly, and like many before him and since, McD is distracted enough by fame to want it to be total and all-encompassing, and while it is phenomenal to be fawned over, McD is consistently drawn to the black woman at the edges of the crowd, whom he assumes is diffident, as far as it concerns his talents, because she refuses to approach him. So why is she there every night, staring at him? The larger his crowd of admirers grows the more determined he becomes to win her over too.
Chapter 30
Her name is Haliday Clay - nicknamed WhatFor by Blanche because Blanche suspects that beneath Haliday's brooding, quiet veneer lurks a feisty, determined temper. WhatFor pursues McD by appearing not to pursue him. Blanche knows McD's weakness for adoration, and WhatFor appears to be a master of denying what she secretly appears to want. A runaway slave, is what Blanche thinks. Of course McD is completely won over, offering WhatFor a position with the troupe as a seamstress. Blanche agrees, thinking it is better to hold WhatFor close than to have her scheming out in the world. But Blanche baits her. What is in the suitcase? At the mention of it, WhatFor clutches it more tightly. When Blanche infers that WhatFor might be a runaway slave, WhatFor's anger registers in her eyes, and if those eyes could they would have ripped out Blanche's heart.
Chapter 31
In Allentown and Scranton, the Immortal Bard Players attract their largest audiences yet, and they are asked to book a theater in Philadelphia, which Blanche rejects (she cannot return to Philadelphia). McD says the offer is too good to refuse. That night, after the performance, Blanche disappears. The Reverend, guilty that his love has driven her away, tracks her down 10 miles outside Scranton - where she is paralyzed with fear, unable to get herself to cross the bridge above a roiling river. The Reverend takes her in his arms, saying he takes full blame for any unhappiness he may have caused. Blanche finds the Reverend's self-loathing too self-centered; she requires at least some undiluted adoration. Finally, they're discovered by McD, who threatens to disband the troupe. But, oddly, asked to choose between them, Blanche will always choose McD.
Chapter 32
Alone, that night, McD tells Blanche that he has nearly convinced himself to get rid of The Reverend. McD wants to go back to serious acting, he says. But Blanche reminds him of the box office, and finally McD convinces himself that he is making a business decision. As the players move south to Baltimore, then Richmond and Washington, this is not a happy foursome. Performances become more dependent on wine and champagne. Mistrust, duplicity, self-love, self-loathing - all of this is understandable in almost any theatrical circumstance, but WhatFor has added an extra dimension of otherness, and secrecy, threat and fear. One night, The Reverend reports to Blanche that he has seen WhatFor talking with Pinkerton guards.
Chapter 33
The next night, after delivering Lady Macbeth's line - Come, you spirits that tend on mortal thoughts, unsex me here - Blanche looks out and sees her father sitting in the audience. Racing offstage, passing McD who is about to get another pie in his face, Blanche sees WhatFor in the wings, watching Blanche's father too. Instead of going to her own dressing room, Blanche rushes into McD's, heading for the little space that WhatFor has carved out for herself, where she now feels comfortable enough to leave her suitcase. Finding it, Blanche breaks the lock and discovers a contract of the ownership of a slave, named Haliday Clay. The owner is Blanche's father.
Chapter 34
What happens next occurs in rapid succession as do most spirals toward doom, with everyone involved swearing that they never saw "it" coming. Backstage, Blanche walks into the wings from McD's dressing rooom, still reading her father's contract of ownership of WhatFor. Then her father shows up in the company of two men who are obviously private detectives – self-important, enormous – Blanche understands what has occurred. Her father has offered WhatFor freedom in exchange for Blanche's whereabouts. WhatFor has lead them to her. But what she can't figure out is why her father wants her back? When pressed he reveals the nature of a contract he has that involves her, another marriage to an older merchant from Gloucester, who has seen a painting of Blanche and will not hold her having been accused of murdering her last husband against her. WhatFor suddenly appears, seeing the contract in Blanche's hand. "That's mine," WhatFor shouts impulsively. WhatFor's freedom at the expense of Blanche's. Blanche escapes into her dressing room with the contract.
Chapter 35
Bolting the dressing room door, Blanche listens to see if the private detectives are massing to break it down - then she hastily throws random things like ribbons and stockings into WhatFor's suitcase, which she still carries. The door is broken open - but not by Pinkertons. It is the Reverend who stands there with a gun in his hand, which he places to his temple. "I will blow my brains out, I swear it. I cannot live near you and not be with you." "Close the door," Blanche says, continuing to pack. But after shutting the door, the Reverend kneels beside it, holding the gun to his right temple. "Please take me with you if you're leaving." Before she can respond, the door is thrown open again - McD this time - and the door accidentally hits the Reverend's right elbow, which jiggers his finger on the trigger, which discharges the gun. The Reverend is thrown back senseless by the shot, gushing blood, aghast to have finally been taken at his word - he dies.
Chapter 36
McD can hardly comprehend the fractured nature of what has ensued. The blood, the Reverend's broken face and uncomprehending stare. As WhatFor rushes in, grabbing for her suitcase, Blanche wrestles her to the floor. And thinking it an act of self-preservation, McD turns to run, finally noticing the Pinkertons, who are advancing on Blanche's dressing room. Side stepping them, McD races into his own dressing room, where he throws off his costume, puts on a suit and winter coat, and grabbing the company strong box, heads out his dressing room window which leads to the alley where his fans nightly mass. And there they are in even greater numbers than previous nights. Rows of them lined up smiling, giddy, hands with books and pens outstretched - and in the street, carriages wait with excited female fans proffering more autograph books through open doors. A horse rears. Dazed, smiling nervously, McD signs several books then makes the fatal mistake of stepping off the raised wooden side walk into the street.
Chapter 37
McD falls backwards, his left hand, which grips the strong box, swings back, hitting a horse squarely in the fetlock joint. The horse spooks and rears. A carriage wheel rolls over McD's foot. He screams out, hurt and trapped between another horse and a shiny yellow carriage, from which a matronly woman calls down to him to sign her book. But a leather button on his overcoat has become lodged between the spokes of her carriage wheel, and as the carriage breaks free McD is dragged to the ground. He doesn't have the presence of mind to rip off the button or the coat. Another horse rears, and another whinnies pitifully. Carriages crash into one another, their drivers pulling reins this way and that as one carriage after another rolls over McD, the pain slicing him in two. Blanche, he whispers. His head rising, he looks back over his shoulder. What had he been thinking, leaving Blanche alone? Hers is the only love he ever knew or trusted. Casting the strong box aside, he tries raising himself to go back for her but he is as good as dead. Another carriage wheel rolls over his neck, and it is over; he is gone.
Chapter 38
McD's dying intent to help Blanche actually comes to fruition. With pandemonium exploding outside the theater with everyone realizing that McD has been crushed to death, screams and confusion overflow among the audience and over the footlights onto the stage. The Pinkertons race into the thick of it, momentarily stranding Blanche's father. Seeing a chance to escape, Blanche, still clutching the suitcase, leaves WhatFor behind, lunging ahead into McD's dressing room and the window that leads to the alley. Clearing the window, racing into the street, Blanche sees the commotion without seeing the source of it. There is a railroad station on the other side of Long Bridge, across the Potomac, not far from the theater, on First Street. If she can only catch the omnibus, but it is already halfway across the bridge. And running for it, she is startled when WhatFor catches up to her, again grabbing for the suitcase. A fragment of WhatFor's quilt sticks out of it. WhatFor tugs on it with such force that Blanche is thrown off-balance, and as she hits bridge's railing, she teeters backwards, horrified, clawing at the air, releasing her hold of the suitcase as she tumbles into the river below. As WhatFor runs across the bridge toward the train station she can hear Blanche's screams, which trail off into the dreaded, icy water as Blanche is carried away.
Chapter 39
"I shoulda helped that woman," WhatFor says to herself as she walks the tracks outside Alexandria. She didn't like Blanche but it wasn't right not to even reach out to try and grab her. It was the suitcase - everything she has in the world. The quilt. The contract. He has got to honor it. She led him to Blanche. She did what she said she would do. It is an inky-black night. No stars. Thick woods. She thinks she's heading north. A passenger train rolled by hours ago, the A & W, Alexandria and Washington Line. She was too tired to grab hold of the freight car as it passed. WhatFor needs rest. She curls up in a tight ball around the suitcase, shivering, her face pressed against brittle leaves, the quilt wrapped tightly around her. She sleeps without dreaming; she's not sure for how long. Then the long woeful moan of a distant train whistle rises from a nearby valley. She crouches beside the tracks, hearing it rumble closer, feeling the vibration of its great cacophonous bulk. Freedom train. It whirs into view, a blast of hot air accompanying it: the engine, the coal car, the passenger cars, the dining cars, the freight cars. She leaps as it chugs up a slight rise - enough time to grab hold of the bar between two cars. She flings her suitcase up, then the quilt, which flaps in the roaring wind. WhatFor stumbles – she should have helped Blanche. WhatFor's foot slips, she is sucked under, as if that train will eat her alive. She disappears into its bowels then is spit out, lying bruised and broken on her back staring at the quilt waving its way to freedom. It is too painful to breathe, and so, after a moment, she stops.
Chapter 40
Four deaths on a single night, each related to the other, each gone before his or her time. It isn't fair. Is it ever? Yes, the spirits say. Yes it is sometimes fair. You live a life. You earn a peaceful death. But not these four - the Reverend, McD, Blanche and WhatFor - restless spirits returning ceaselessly, searching for a way out of life. In each subsequent decade, in each generation they have sought reincarnation, hoping to work out their lives and untimely deaths. They have come back as good people and bad - a nurse, a banker. The Reverend has been a prizefighter and a construction worker. McD was a bodybuilder - Mr. Italian-America 1957. But none has achieved a quiet soul. And after each death they reawaken to wander. No one has done for them what Daniel and Daisy have done. This time they have been honored in the telling of their tale. Wonderful artifacts have been made for them. But still they remain. Waiting. Will it happen this time? Finally. Will they rest?
They rest. They really do. All of them. McD has vanished, his fame secured by the artifacts that players of Ghosts Of A Chance made in his honor. Blanche escaped the traps of life; she is free to discover whatever there is to discover, and this time in peace and comfort. WhatFor is free for all time. The Reverend is beyond temptation; he languishes in a goodly repose. They would thank you if they could for all you've given, for the final quests that almost two hundred fifty of you played last Saturday, October 25th 2008. Their restful silence is their thanks. They have slipped this earth. Goodbye.


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Jirga victim seeks security
SHADADPUR, July 21 2006: Despite Sindh Home Minister Rauf Siddiqui's warning that stern action would be taken against holders of Jirgas, the menace is successfully surviving. Bhongar Khoso, who has been asked by a Jirga to give his two minor daughters as fine for failing to return a loan of Rs 25,000, threatened on July 20 to set himself and his children on fire if his family were not provided with security. He alleged that armed men of the Rind tribe were threatening to abduct his daughters if he did not pay the debt. He also alleged that police were not arresting Sardar Ghulam Rasool Alkhani and 16 other participants of the Jirga.
Source: The News


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Make Herbs Fun Again Summer Camp -- Happy Camper
Summer camp begins shortly. Get ready to make herbs fun again. Over the next month, you're going to get an email every day with a short herbal mission that you can complete in 5 to 15 minutes, in the margins of your busy life. It's going to be fun. And there will be camp songs, archery, and s'mores. You're going to be a Happy Camper. The entire camp experience is delivered virtually through email and a Facebook group. And through it you'll reconnect with your local herbal allies, the basic techniques that every herbalist uses, and you'll make some essential herbal remedies that your apothecary requires for winter. Let's get started.
For more information.


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Hiya all
Iv not been on for a few days, still not feeling too good, all iv done is sleep, cough, take tablets, wheeze, suck on my inhaler, get out of breath............and it goes on, im just shattered with it. I thought i was feeling a bit better today, but no.
Anyone else having the same viral chest infection? I know a few people that have had it.
Iv had it just over a week now.
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About us
Economics and Business Educators (EBE) NSW is an active professional teachers association, representing and supporting teachers of the Board of Studies, Teaching and educational Standards NSW Economics, Business Studies, Legal Studies and Commerce courses. It was established in 1968 and operates as a company limited by guarantee. EBE NSW is governed by a Board of Directors who are all educators. It is a member of the Professional Teachers' Council NSW (the coordination and consultancy body for professional teachers associations in NSW) and also an affiliate member of the national subject association, Business Educators Australasia.


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Location: US:PA:Hershey
Work Type: Full Time
Shift: Day
This role is responsible for oversight in managing and directing departmental operations and labor within Supply Chain Management Perioperative and Heart & Vascular Institute (HVI) at Penn State Hershey Medical Center to align with the organizational strategic imperatives and goals. It is also responsible to identify best practice in product flow including; inventory management to include the storage and the transportation of all materials and inventory to ensure prompt delivery to the customer. The manager will develop and maintain policies on general logistics and procedures to maintain overall inventory based on demand, to standardize practices and procedures and to incorporate lean principles into distribution model. Finally, the role will develop KPIs for all correlating inventory areas that will lead us to be a more lean and efficient Supply Chain team.
MINIMUM QUALIFICATIONS: Bachelor's Degree in Business or Healthcare related fieldFive (5) years of hospital management experience in either an administrative, financial or Supply Chain / Materials Management leadership capacity required.Two (2) of the five (5) years in Supply Chain Supply & Distribution roleExperience with supply technology and its deployment requiredExperience managing projects required.Experience with Microsoft Word & Excel, Data Base systems is requiredExperience with developing KPIs requiredKNOWLEDGE, SKILLS, & ABILITIES: Analytical Skills required.Strong written and verbal communication skills required.Ability to work independently and in teams is required.Knowledge of Non-Profit Business decision making models is required.PREFERRED QUALIFICATIONS:
CPM or other material management and purchasing certifications preferred.Green Belt/Black BeltSix Sigma experienceOSHA, Federal Registry, State, IATA, CFR49 and Fir Safety trainingHaz Mat CertificationInternational Air Transport Association Certification
If chosen for this position, you may be required to pass a Post Offer Employment Physical Exam in accordance with the measurements listed in the Work Task Analysis (WTA) report. This job description is a general outline of duties performed and is not to be misconstrued as encompassing all duties performed within the position. All individuals (including current employees) selected for a position will undergo a background check appropriate for the position's responsibilities.
Penn State Health is committed to affirmative action, equal opportunity and the diversity of its workforce. Equal Opportunity Employer - Minorities/Women/Protected Veterans/ Disabled.
Union: Non Bargained


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Cisco Adder License for the IOS based Wireless Controller - License ( license (electronic delivery) ) - 1 access point - for Cisco 5760 Wireless Controller, 5760 Wireless Controller for High AvailabilItem#: 9498200 | Model#: L-LIC-CTIOS-1A
- Price:
- $136.99
$6.99 Shipping
- Shipping:
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Additional Resources
Cisco Adder License for the IOS based Wireless Product Details
Product Type: License ( license (electronic delivery) )
Hardware License
License Qty: 1 access point
Compatibility Information
Designed For: Cisco 5760 Wireless Controller, 5760 Wireless Controller for High Availability
Additional Resources: Product Manuals
Recommended Items
Related ItemsPrevious
Manufactured by: Cisco
Warranty provided by: Cisco
UPC No: 0821831091711
Mfg Part No: L-LIC-CTIOS-1A
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( Length:0, Width:0, Depth:0)
Shipping Weight: 0.0100 pound(s)
Click here for full warranty and support information
- Cisco logos are registered trademarks of Cisco. All others trademarks and copyrights mentioned herein are the property of their respective owners.


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By Marianne Binetti
My favorite plant combinations are couples that work well together to solve problems and make each other look better. Meet these couples with perfect marriages of convenience.
Purple Fountain Weeping Beech and Doublefile Viburnum
The Purple Fountain weeping beech tree, above, is a tall, dark and handsome specimen. Now marry it off to the lacey, pure-white wedding gown look of a doublefile viburnum and you have a stunning bride and groom with a beautiful contrast in form and foliage. Got deer? Together these two say, "Not tonight, deer."
Sedum Angelina and Red Head Sempervivum
It is hard to keep plants in an urn alive without daily watering, but these two sedums make a dramatic union without any drinking problems. Hardy golden sedum Angelina drapes over the sides and surrounds the focal point sempervivum, or hens-and-chicks. This variety is called 'Red Head', and both survive Northwest winters.
Creeping Jenny and Black Mondo Grass
This ambitious couple adds flair to my front yard bed and also keeps down the weeds. This bed is in dry shade, which helps to control the domineering personality of the blond creeping Jenny. But I still need to get snippy with her at least once in early summer so she won't overpower the dark edging of the black mondo grass border. I would rather snip than weed any day. Both plants add year-round foliage color.
Pieris, Thuja and Clematis
I love variegated foliage in front of a solid-green backdrop. This combo looks great all winter. Variegated Pieris japonica stands out against the dark-green Thuja 'Emerald Green' hedge and creates a living wall into a garden room. In summer the purple clematis adds some excitement to spice up the marriage. You don't need a lattice for clematis when you grow a combo like this, and all three thrive in an area near cedars with very acid soil.
White Bark Birch and Purple 'Rose Glow' Barberry
Winter landscapes light up with the white bark of birch trees, and the contrasting dark foliage of a drought-resistant purple barberry brings out the best in this couple. The barberry in this photo has creamy-white variegation in the new spring growth and is called 'Rose Glow' barberry. Another low-maintenance duo that solves the problem of deer damage.
What plants have the perfect marriage in your garden?


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Devon, United Kingdom
Many of our farms welcome dogs and provide a fantastic selection of dog friendly holiday cottages and B&B accommodation. Most are surrounded by breath-taking scenery, coasts or moors, making dog walking an absolute joy! Rest assured, when it comes to daily exercise, 'scamp' will enjoy every day's adventure!
Please check out our website for more details and availability http://www.devonfarms.co.uk/fd/dogs-welcome/dog-friendly-holiday.html
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Holy Cross Primary
Catholic Voluntary Academy
Loved, Challenged, Valued
Today we made notes on why we like or dislike our reading books. We then chatted with our friends to tell them why and if we would recommend our books.
We use cookies to track usage and improve the website.
Click here for more information.


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Unicaw89, aka Cody Williams, has a really cool Despicable Me Minion tutorial on Youtube= http://www.youtube.com/watch?v=2NP5x6lexPM.
He is quite a character. His teaching approach and personality just works well for him in my opinion. He is a bit of a show off, tries almost a little too hard to entertain you and be funny, and you can tell he is a daredevil and is a high sensory seeker. It's like he is a real life Bart Simpson only with goals and a drive to succeed,lol. It just works for him and he is likable, he pulls it off in my opinion. I enjoy his tutorials and look forward to replicating and reviewing more of his designs.
Now I made some changes. In my first iteration and replication of his design I added a little pocket that almost looks like a teddy bear head. I also took a clear 350, drew an eyeball on one side, then took a silver 160 and made an eyepiece. The effect is quite cool in my opinion. I also used an un-inflated 350 for the band for eyepiece and drew on hair and added black hands as the minion characters wear black gloves.
The head was a bit too long in the first iteration and I was curious what it would look like without the black running between both legs.
Second Iteration, I adjusted head proportion and also tried making overalls look more I guess you would say smile shaped. It connects to the x in the overalls of his design with the black round balloon. There is not connection between feet. I realize that I made the legs too long in both iterations.
Third Iteration, I changed it around some. I got rid of the pinch twists in the front- and the criss cross x in the front. I tied the end of the black round to two ties each connecting to the opposite pinch twist for the pant as it were.and I made the middle of the overalls a bit too big but other than that I am liking it. I also used 260's for the legs and feet as well rather tan 350's. I am still not satisfied though and will come back to this a different day. I might play around with 160's for the middle of the overall part next time or do some combination.


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Monday 26 March 1928
It was Monday, under the sign of Aries. The US president was Calvin Coolidge (Republican).
Famous people born on this day include Carole Carr and Robert Beck.
The Trail of '98, directed by Clarence Brown, was one of the most viewed movies released in 1928
But much more happened that day: find out below..
You can also have a look at the whole 1928 or at March 26 across the years.
Old Newspapers
Have a look at the old newspapers from 26 March 1928 and get them!
Which were the most popular movies released in the last months ?
Find out your future
Get a FREE Numerology report based on the digits of 26 March 1928!
Wish him/her..
Historical Events
Which were the important events of 26 March 1928 ?
- Saint Emmanuel (died 304)
- Saint Ludger
- Saint Larissa
- Prince Kuhio Day in Hawaii
- Zoroastrianism - Prophet Zoroaster's Birthday.
Famous Birthdays:
- Carole Carr: Singer / actress (Down Among the Z Men).
- Robert Beck: American scientist and a pioneer in the field of nuclear medicine.
- Nunzio Gallo: Italian singer who represented his country in the 1957 Eurovision Song Contest, coming 6th.
- The China Academy of Art is founded in Hangzhou, Republic of China (first named the National Academy of Art).
- April ndash The last section (wise ndash wyze) of the original ''Oxford English Dictionary'' is completed and ready for publication (''OED'' (1933, 1978 vol. 1, pp. xxv, xxvl)
Where were your ancestors 100 years before 26 March 1928
Discover their stories. Preserve your legacy.
Our team of professional genealogists provide full-service genealogical research for clients worldwide, helping them discover their roots and personal history through records, narratives, and DNA.
Subscribe to our Newsletter
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...and if 26 March 1928 was your Birth Date then Join our Birthday Club!
Make this date unforgettable
Genealogy: find out your family heritage
Which were the most popular books released in the last weeks ?
Remember when
What videogames would you be playing back in the days ?


text: Our vision is enable all students to have the opportunity to study and achieve in the exciting and life changing qualification of Computing. We want to empower students to be safe online so that they are aware of the dangers, know how to avoid them and what to do if a problem does arise. Creating productive members of society where their computing ability enables, rather than limits, them to fulfil their potential in this electronic age.


text: Choose from our many premium website designs, which are categorized by business type. Don't worry if you don't see your business type. Just select any design that appeals to you and continue the ordering process. A webmaster will be in contact with you and help you select the best design. Please note the prices below are for the Silver Package. In the next step when you pick your package, you can upgrade and/or add any features or services you want to meet your online needs. Design gallery provided by Pandaje, is secured with a Web Server Certificate. Transactions on Design Gallery are protected with up to 256-bit Secure Sockets Layer encryption. Click on secure icon to view the certificate.


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According to the Bible-Wm. A. Frazier
Knox, IN
(574) 207-3334
Updated 3 days ago
Weddings are a happy place filled with happy memories for the wedding couple and your guests. I certainly gain a deep personal satisfaction from playing such an important part in your lives. This is a Christian ministry specializing in church, home, garden and park weddings. 1 Cor 13:13 KJV 13 And now abideth faith, hope, charity, these three; but the greatest of these is charity (Love). I am a non-denominational minister. I have performed weddings in Indiana and Tenn.
This profile has been viewed 2,715 times.
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It's a busy week for us. Today (Monday) there is the Leeds Coalition of Resistance meeting at Leeds Met Broadcasting Place at5.30, and an organising meeting for the Right to Work Campaign at 7.30 in the Swartmore Centre.
Weds is the Day X, a day of walkouts and protests by students and school-students starting at 11AM, with a march from the Universities into town at about 12.
Thursday evening has the big Leeds Against Cuts public meeting in the City Hall at 7.30.
And on Saturday there's the national Coalition Against Resistance conference in London, with a coach leaving the Parkinson steps at 7AM.


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wine list
set menu option 1
set menu option 2
Restaurant Menu
download this menu
to begin with ……..
grazing platter for two 22.50
today's soup we came up with 11
green lipped mussels, chilli lime, coriander & coconut cream 18
beef fillet carpaccio, wasabi aioli, pickled ginger 18
pork & chicken liver terrine, onion jam & crusty bread 18
grilled Canterbury lamb, beetroot & feta puree, balsamic reduction 18.50
pulled pork & lentil ragout, zesty dressing 18
as a salad (small/not so small) ………
roasted vegetable, pinenut, capers & honey coated 14/24
red quinoa, goat's cheese & spinach 14/24
five spice pork, yoghurt & cucumber dressing 16/26
satay dressed beef & noodle 16/26
to get through ………
pork fillet, sweet potato mash, pickled red cabbage, cider jus 32
Akaroa salmon fillet, pesto dressed potatoes & beans 32
slow cooked tomato & cumin shanks, rosemary mash, roasted root vegetables 37
ribeye steak, potato skins, creamy garlic sauce
or simply topped with blue cheese & pear butter 37
citrus roasted chicken supreme, pumpkin & green pea risotto 32
sirloin beef strips, basmati rice, sour cream and mushrooms, caramelized onion 29.50
plus see our specials board!!!
if you'd like extra……….. green salad or vegetables 7
to finish with……….
passionfruit panna cotta, white chocolate wafer 14
pecan, cinnamon & apple tart, brandy cream, tuile 14
chocolate & marmalade pudding, vanilla ice cream 14
crème brulee cheesecake, Cointreau orange segments 14
If you have a special dietary requirement, just sing out
and we will gladly make a tasty treat for you.
We trust you have an enjoyable experience.
Have a Great Day, I am!!!
Please: one account per table


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TEARS Animal Rescue faces an unsure future: BUT YOU CAN HELP
Our vision as a Pro-Quality of Life organisation where we rescue, rehabilitate and re-home animals in the communities that we serve (and in some that we do not even remotely have any direct obligation to) has been severely tested this year!
Expenses and costs have hopelessly exceeded our fund-raising initiatives, revenue from our retail outlets and current donations by our valued and appreciated supporters.
Steps we have taken to ameliorate the situation include:
- Substantially reducing our staff complement in excess of 20% – our biggest overhead.
- Continuing our efforts and initiatives to re-home the rescued animals in our care tirelessly.
- Cutting back on our basic care and services to our impoverished communities except where people are able to make a financial contribution towards the services we provide.
- Placing a temporary hold on the FREE sterilisation and puppy vaccinations offered to the communities that we serve.
- Suspending certain projects until our circumstances allow.
YOU can help TEARS to survive
We need all the support possible, to prevent the untenable situation of closing our doors!
You can play your part in this by:
- Setting up a tax-deductible debit order via our website: http://tears.org.za/donate-now/
Bank: Standard Bank
Branch: Fish Hoek
Branch Code: 036 009
Account Name: TEARS
Account Number: 07 389 061 8
SWIFT Code: SBZAZAJJ
- Supporting our retail outlets: http://tears.org.za/shops
- Adopting an animal and getting friends to adopt: http://tears.org.za/dogs/ or http://tears.org.za/cats/
- Volunteering for one of our many activities: http://tears.org.za/volunteer/
- Leaving a Bequest to TEARS in your Will (tax deductible): http://tears.org.za/leave-a-legacy/
Who can rescue the rescuers? Only YOU!
Be part of our mission to bring relief to animals who suffer abuse. There are many ways you can make a difference in your community.
There is never a dull moment with us. Share in our special moments, whether news, events, hot topics, fundraising and supporter info.


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Shop at Fred Meyer and use your Fred Meyer rewards card to help the Camas Athletics Booster Club support our incredible Student Athletes! Involvement in sports plays an important role in the development of our student athlete's life skills. Playing sports teaches discipline, team work, social skills, and keeps our youth healthy and active.
With the help of our donors and sponsors, we are providing our students with the most up to date equipment, technology and uniforms in order for them to perform and compete at the highest levels with the best resources available. Our Camas students thrive with the help of our community support.
Since 1994, the Camas Boosters have been fundraising to shore up the gap between the needs of our Athletes and the District's Budget. The Boosters also award two — $3,000 college scholarships each school year. It just takes a moment to support your Camas athletes when shopping at Fred Meyer — and you won't even break a sweat!


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|Catalog Number
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|100 ug
|Buy Now | Add to Cart
Type: Mouse IgG
Applications: IHC
E=ELISA; FACS; FC=Flow Cytometry; FPLC=Fast Protein Liquid Chromatography; GF=Gravity Flow; HPLC=High Performance Liquid Chromatography; ICC=Immunocytochemistry; IF=Immunofluorescence; IHC=Immunohistochemistry; IP=Immunoprecipitation; NAC=Non-adherent Cell Assays; NB=Neutralization of Bioactivity; SE=Sandwich ELISA; TPE=Targeted Protein Expression; WB=Western blotting; ; AC=Adherent Cell Assays; FM=Fluorescent Micsroscopy; ; ; BSC-CM5= Biacore Sensor Chip CM5; BSM=Biosactive Small Molecule or Peptide; CDM=Cell Differentiation Media; ; ; ; ; ; Health and Fitness; ; ; DNA Extraction/Purification; ; In vivo Like Assays
Species Reactivity: H; R
B=Bovine; Ca=Cat; Ch=Chicken; D=Dog; EQ=Equine; GP=Guinea Pig; H=Human; M=Mouse; P=Porcine; Pr=Primate; R=Rat; Rb=Rabbit; Y=Yeast; Xe=Xenopus; Ze=Zebrafish; ; ; ; NA-Not Applicable; STP=Step-Tactin Proteins; All
Format: Protein G Purified - liquid
Immunogen: E. coli-derived, recombinant human Oligodendrocyte transcription factor 1 (hOlig1; aa 1 - 272).
Olig1 and Olig2, which have been implicated in oligodendrogenesis, are expressed in the region of the ventral ventricular zone of late embryonic spinal cord where oligodendrocyte progenitors appear. Olig3 is transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development. In adult, expression of Olig3 is primarily detected in neural tissues.
Image: Olig1,2,3 staining in Mouse Fetal Brain Tissue-Sections were stained using Rhodamine Red-conjugated donkey anti-mouse secondary antibody and counterstained using Fluoro Nissl (green).
Olig1,2,3: Customer Data and Publications


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"People who are in the market for a condo look at the reputation of the building, the management and whether utilities are included as part of the condo fee," she said. "They want a conservative board of directors that is financially conscious and keep the property in A-1 condition, but do it in a cost-effective way."
Cover story: Appraisal key to selling price →
Meanwhile, buyers in the condo market look at their own set of factors when it comes to price, Ms. Steorts said.


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New images of Troll and I
. Arrive in early 2017 to tell the story of a boy and his friend
control Spiral House shows us two new images of Troll and I , a game that brings us to the 50s, the northern Europe, to offer an episodic adventure third person comes action with two very different protagonists together: child Otto, agile and skillful with the spear, and control, a magical giant still his childhood.
The game will allow cooperative and combines stealth and action with elements of puzzle, hunting and survival.
The launch is scheduled for early 2017 Maximum hand . Games
(Visited 1 times, 1 visits today)
New images of Troll and I