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Originally posted on NESN.com | Last updated 9/14/13
Franklin Morales is somewhat of a forgotten man in the Red Sox' bullpen. That might not be the case too much longer. Morales' health has prevented him from building on his solid 2012 season, but he's now moving in the right direction and could carve out an important role. Morales pitched a perfect ninth inning in the Red Sox' 5-1 win over the Yankees on Saturday, and we could begin to see the left-hander more frequently in the later innings, particularly when the club's primary late-inning relievers aren't available. "He adds another dimension to our bullpen," Farrell said Saturday. "Those innings where we need a strikeout, he's got that capability if it's a little bit of a dirty inning or someone's got to come in and pick up a starter. He can be a huge boost to us going forward." Morales transitioned to a starter in 2012 and was one of Boston's lone bright spots in the otherwise tumultuous Bobby Valentine era. Morales' 2013 season didn't get off the ground until late May, however, as the southpaw dealt with a bulging disk in his back. Then, after a shaky start to his season, Morales landed back on the shelf with a pectoral issue. Morales appears to be healthy now, though. He has five scoreless outings this month, during which he has shown improved control, and it sounds like Farrell is willing to give him a chance to prove himself over the final couple of weeks of the regular season. "It's extremely important," Farrell said of Morales' improvement. "I think his last seven or eight times out, we're seeing consistent velocity with what he's pitched with the last couple of years. He's had a hit-and-miss year this year from a health standpoint. That's behind him, and to see the power with which he's throwing with, that's encouraging. Morales was stretched out earlier in the year, as he was expected to serve as a spot starter. Now that the Red Sox have good rotational depth, Morales will serve as a middle relief option and could see more high-leverage situations if he continues down the current path. "The increase in stuff clearly has put him into the position he's in right now," Farrell said Saturday. The Red Sox lost a lefty capable of generating swings and misses when Andrew Miller went down with a season-ending foot injury earlier in the year. Morales might be able to serve in a similar capacity. Have a question for Ricky Doyle? Send it to him via Twitter at @TheRickyDoyle or send it here. Filed under: Boston Red Sox, Ricky Doyle, Top Stories
PLAYERS: Franklin Morales, Bobby Valentine, Andrew Miller
TEAMS: Boston Red Sox
TEAMS: Boston Red Sox
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Angling in the heart of the
Yorkshire Dales since 1912
We have
received the following invitation from Orvis Harrogate:
Members of the Richmond and District
Angling Society are invited to a presentation evening at
the store (21-22 West Park, Harrogate, HG1 1BJ) on
Wednesday 16 November 2016. This special event, which
will begin at 18:00, has been planned to celebrate the
upcoming launch of Orvis' new 10ft #3 Recon rod and the
recent publication of Jonathan White's excellent book
Nymphing The New Way: French Leader Fishing for Trout.
Stealthy, sensitive, versatile and capable of producing
impressive catches, French Nymphing and related
leader-only approaches are becoming increasingly popular
on rivers and streams worldwide. As Orvis Harrogate's
Fly Fishing Specialist I will be speaking on the evening
about the fascinating history and development of these
methods, their associated fly patterns and how to make
the most of them on local venues.
Guests will also be able to see, handle and pre-order
the new 10ft #3 Recon, which is competitively priced at
£379.00 and ideal for modern, light-line fly fishing on
running waters. All paid-for pre-orders will receive a
complimentary copy of Nymphing The New Way (normal price
£20.00), which will also be available to purchase
With light refreshments provided, plus the opportunity
to attend a follow-up on-the-water demonstration, I very
much hope that this will be an interesting, informative
and enjoyable evening for all. I look forward to
welcoming as many Richmond and District Angling Society
members as possible, and would greatly appreciate it if,
at all possible, anyone intending to attend could let
either myself or a fellow member of staff know at their
earliest convenience, in order to facilitate seating and
catering arrangements.
River Fly Life
If what lurks on the
bottom of rivers interests you then the Yorkshire Dales
Rivers Trust would like to hear from you. Monitoring fly
life is an important indicator of the health of a river
ecosystem and the trust is looking to set up a team of
volunteers to regularly monitor a number of locations
providing information towards a project to improve
tributaries of the Swale.
For those who don't
know a caddis fly larva from a mayfly nymph the trust is
offering the chance to learn from experts at training
sessions. To find out more contact Alastair Logan –
or call 07984 615239. The first opportunity for training
is 7th April 2016 at a venue near Thirsk,
when the tutor will be well-known fly fishing
entomologist Stuart Crofts.
Richmond anglers to share
purpose-made fishery in ground-breaking deal
We are
delighted to advise members that
Thornaby Angling Association (TAA), which
15 years ago began development of the purpose-made Mill
Farm Fishery on farm land at Gilling West, has agreed to
Richmond & District Angling Society (R&DAS) sharing the
facility on an annual basis.
TAA has invested significantly to
establish Cow Pasture Lake and Mill Lake, which cover
approximately five acres, as a well-stocked fishery
catering both for coarse and trout anglers.
In the most recent stocking programme
bream, tench, roach, barbel, crucian and assorted carp
were added to Cow Pasture Lake, which is exclusively
coarse fishing. As well as holding coarse species,
substantial numbers of rainbow trout of mixed sizes are
introduced annually to Mill Lake.
"We are delighted to welcome angling
colleagues from R&DAS to share the great fishing at Mill
Farm Fishery," commented Gordon Angel, Chairman of TAA.
"The lakes have the capacity to be fished by more
anglers and when we were approached by R&DAS both clubs
recognized the potential of a shared arrangement being
to their mutual benefit."
R&DAS annual permit holders will be
eligible to fish at Mill Farm on receipt of their
2016/17 permits. Purchasers of R&DAS day and week
tickets will not have access to the fishery.
"We are really looking forward to R&DAS
members using the fishery," Richard Almond, Chairman of
R&DAS, said.
"The new arrangement extends the
stillwater fishing opportunity we are able to offer
members. Our current stillwater, which we will cease
leasing in mid-April, was confined to coarse anglers
whereas Mill Farm Fishery also offers an opportunity to
those who enjoy catching trout, including a period
reserved for fly fishing."
"TAA were very open to our approach and
we look forward to sharing fishing experiences with
fellow anglers on the bankside."
Richmond & District
Angling Society will hold its 104th Annual
General Meeting in The Bishop Blaize, Market Square,
Richmond on Tuesday 2nd December, 2014,
starting at 8 pm. All members of the society are welcome
to attend, with full members being eligible to vote. It
would be helpful if anyone intending to attend the AGM
could let the secretary Phil Brown know (01748 833822)
as refreshments will be served at the end of the
meeting. The committee is also looking for new members,
with all full members who live within the district of
Richmondshire being eligible to serve.
© 2009-2016 Richmond and District Angling Society

subset: commoncrawl


text: Aug 02, 2010 - Ocean Ana Rising, Inc seeks to raise awareness about violence and abuse towards women through a unique and cutting-edge art form. "A Healing Touch: Digital Offerings of Peace for Women Survivors" is a mobile digital art exhibition featuring the peaceful offerings of 25 international artists who exclusively draw and paint on iPhones, iPads and Androids. The show is curated by artist, Mia Robinson, and opens Friday, August 20th at the L'Eclat de Verre Versailles Gallery in Georgetown, DC.


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Test your drawing skills by drawing the Kiddie Kobbler shoe!
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Come See Us!
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Discover our enchanting Spa Boutique
enjoy a relaxing aromatherapy massage
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Spa Terme Di Aroma is a Philadelphia-based holistic day spa that originates from the beliefs and practices of the great centers of healing and meditation of the ancient Mediterranean world. These legendary places of antiquity practiced a holistic approach to health as a balance of mind, body and spirit. Among the healing arts were aromatics in the form we know as aromatherapy, the use of the natural power of essential oils extracted from plants and trees, to restore and rejuvenate health and well-being.
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Retreat into our signature full body Aromatherapy Massage, following your massage, luxuriate with our Indian Foot Massage.
From The Blog
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The Autumnal Equinox on September 23rd marks the first day of fall.
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During this summer's music and opera festivals, travelers to Europe can delight in internationally renowned performing artists and world premieres in beautiful and historic settings. Opera in a Roman open air amphitheatre, classical concerts in Renaissance churches, or arias in grand opera houses and castles are just a few of the experiences in store for travelers and music lovers this spring and summer of 2017.
Arena di Verona Summer Opera Season
Verona, Italy
June 23 - August 27, 2017
The Arena di Verona, the ancient Roman amphitheater in Verona, opens its summer opera season with Nabucco. This popular summer opera festival brings a staggering 16,000 people to each production. The outdoor opera venue, the Arena, continues with Aida, Rigoletto, Tosca, and others.
Opera at the Baths of Caracalla
Rome, Italy
Summer 2017
Teatro dell'Opera holds its summer season of opera outdoors under the stars at the Baths of Caracalla, the ancient Roman spa complex in Rome. This year, the company presents ballet as well as operas.
Festival Puccini
Torre del Lago, Italy
July 14 - August 19, 2017
Torre del Lago is near the the Tuscan town of Viagreggio and 35 minutes from Lucca, the birthplace of Puccini. This year, the festival's open-air theater will feature productions of La Rondine, La boheme, Madama Butterfly, Turandot and Tosca.
Rossini Opera Festival
Pesaro, Italy
August 10 - 22, 2017
Established in 1980, the festival at the birthplace of the Rossini features performances of his works. This year, Il viaggio a Reims, Torvaldo e Dorliska, Stabat Mater, among other programs are scheduled.
International Festival of Lyric Art
Aix-en-Provence, France
July 3 - 22, 2017
The festival in Aix-en-Provence presents opera, and concerts of orchestral, chamber, vocal and solo instrumental music.
Holland Festival
June 3 - 25, 2017
The Holland Festival is The Netherland's oldest performing arts festival featuring theater, music, opera, modern dance as well as visual art and film. Performances take throughout Amsterdam at venues such as the city theatre, the opera, the Concertgebouw, and Muziekgebouw concert halls and the Westergas factory.
BBC Proms
London, England
July 14 - September 9, 2017
The BBC Proms presents concerts at the Royal Albert Hall and chamber music recitals at Cadogan Hall. There are also a number of outdoor events. So named from the practice of the audience promenading, or strolling, in the concert hall during the performance, "prom" now refers to the areas of the hall where audience members stand. It's considered to be the best place in the house to be.
Glyndebourne Festival
May 8 - August 26, 2017
The festival presents six productions each year in a 1,200-seat opera house in East Sussex, England. In 2017, La traviata, Don Pasquale, among other programs are scheduled.
Wagner Bayreuth Festival
Bayreuth, Germany
July 25 - August 28, 2017
Performances of operas by Richard Wagner are presented in the theater, Festspielhaus, built by the composer himself.
Dresden Music Festival
Dresden, Germany
May 18 – June 18, 2017
Events of the music festival are held in venues throughout Dresden, from churches and museums to the Semperoper and the Frauenkirche.
Salzburg Festival
Salzburg, Austria
July 21 - August 30, 2017


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Maundy Thursday Service, Communion 7:30 pm
Sundays - 10:00 amChoir Practice - Thurs 7pm
Come Visit Us at Ebenezer! We're right at the corner of Brimley & Steeles. Look for the brick building and come on in! - View Map
Sundays - 10:00 am
(905) 477-43655000 Steeles Ave EMarkham, ON Canada


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Feilding High School 1st XV fire in first half to beat Wellington College
A fine first half display helped the Feilding High School first XV pick up a 38-29 away win over Wellington College on Saturday.
The side got away to a great start with their forward pack proving too strong for the Wellington side.
Both teams were down a number of front-line starters, but Feilding's replacement players stood up well.
Halfback Kyle Rhodes, who was one of the best on the park for Feilding, was one of those who took advantage of his chances.
His passing, decision making and improved box kick helped get the side some solid attacking ball.
Up front, Feilding had the dominant scrum with props Ethan McQuinlan and Jack Fleury showing good technique.
Utility Josiah Maraku, who might be set for some time at No 10 with Kody Edwards still sidelined and Leighton Manuel breaking his leg in the match, played well in the midfield, picking up a try.
While Drew Wild's pin-point goal-kicking was just an extension of his strong start to the season.
Up 28-0 at the break, Feilding looked set for a big score.
But they struggled to push on in the second half with some puzzling refereeing decisions going against them.
Feilding bagged a try to wing-turned-hooker Adam Thomas in the second half with his turn of pace catching the Wellington side out.
Wellington bounced back with five tries, but their wayward goalkicking hurt their chances and letting Feilding escape with the nine-point win.
That was Feilding's final match before their four-match tour in Australia which starts on April 19.
Meanwhile, Palmerston North Boys' High School's match against Scots College was cancelled after Kilbirnie Park in Wellington was closed.
Boys' High offered to host the match after Wellington Council made the decision, but Scots College declined.
Their next match is against St Paul's Collegiate at home on Friday.
Feilding High School 38 (Josiah Maraku, Drew Wild, James Bolton, Jack Fleury, Adam Thomas tries; Drew Wild 5 con, pen) Wellington College 29 (5 tries; 2 con) HT 28-0 Feilding
- Stuff


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text: Of all of the arts that have arted, my favorite has to be folk art. The Mengei International Museum is an international folk art museum, but right now they have a collection of pieces from each of our 50 states on display. Josh and I enjoyed trying to look across the room and picking which pieces we thought were from our home states. They had SO MANY quilts. And all of them were good and wonderful. As usual old becomes new again, and many of the patterns these quilts were made from people are working with today! Love!


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Legendary singer and business owner Patti LaBelle and MLB Hall of Famer and entrepreneur Hank Aaron have just been added to the speaker lineup for the 2017 Entrepreneurs Summit!
Each year, hundreds of entrepreneurs travel across the country to attend the Black Enterprise Entrepreneurs Summit, which provides small business owners with the knowledge, resources, and tools they need to take their businesses to the next level. Attendees are also granted access to powerful business leaders, along with the opportunity to meet angel investors and receive one-on-one business consultations. This year, the Summit is May 17–20 in Houston, with the theme "Reimagine, Reinvent, and Reinvest."
LaBelle and Aaron have joined a long list of dynamic businessmen and women at the conference, like gospel legend Yolanda Adams; Bonin Bough, host of Cleveland Hustles; civil rights leader and business consultant Vernon Jordan; digital influencer Lamar Tyler; and elevation strategist Zakiya Larry.
In addition to being a world-renowned singer, LaBelle is the founder of Patti's Good Life, which produces her signature sweet potato pie, desserts, and customized sauces. The "Godmother of Soul" will discuss her distribution partnership with Walmart, and her success in the food industry during a panel discussion titled, "Satisfying Your Appetite for Profits in the Food Products Biz," featuring Yolanda Adams. The two Grammy Award-winning singers will also share insight regarding what it takes to push your products into the marketplace.
Aaron, a former MLB star and the current senior vice president of the Atlanta Braves, will be honored with the A.G. Gaston Award during the B.E. 100's 45th Anniversary Celebration and Awards Gala. The ceremony pays tribute to an exclusive list of large businesses owned by African Americans and their CEO's, who are among some of the most powerful business leaders in the country.
REGISTER NOW to learn more about entrepreneurship and business success at the 2017 Entrepreneurs Summit on May 17–20 in Houston.
Selena Hill is the Associate Digital Editor at Black Enterprise and the founder of the award-winning talk show, Let Your Voice Be Heard! Radio. You can hear Hill and her team talk millennial politics and social issues every Sunday at 11 a.m. ET.
Follow her on Instagram and Twitter at @MsSelenaHill.


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Beat Cop Gaming NewsGamepressure.com
New York of the 1980s, a cop framed for murder, and dozens of humorous references to old cop movies and TV shows this is what you can expect from Beat Cop, an upcoming point-and-click adventure game from Polish indie studio Pixel Crow. The games publisher, 11 bit studios (the creators of This War of Mine) has announced that Beat Cop is going to hit Steam on March 30, 2017. Another old-school point-and-click that launches on the same date is Thimbleweed Park from the veterans of the genre: Ron Gilbert and Gary Winnick.
Beat Cop is a pixel art adventure game from 11 bit studios, the devs of This War of Mine. You play as a cop framed for murder and hunted by the local mafia. Apart from following his daily routine, he needs to turn every stone and find out who set him up. The creators are promising a non-linear story with multiple endings. Beat Cop will be overflowing with the atmosphere and humor of the 1980s as well as inspirations driven from classic American crime television series, such as Kojak, Columbo, Magnum, and Miami Vice.


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This week on Pear Shaped Thoughts we are having a tribute to our husbands. We love and appreciate them and so it's time to celebrate the men that make our lives complete. This way, we make like Jerry Maguire and say 'You complete me' in blog form.
Let me kick of the week with a little story that shows how amazing my husband is.When I was about 11 weeks pregnant I got really sick. I had extreme cramping in my stomach region and because I couldn't tell if it was stomach pain or uterus pain, we were concerned that something might be wrong with the baby. As any prospective parent might do, we hopped into the car to travel to the emergency room.
As we drove, my sickness increased. I think the movement of the car was making me feel worse. Bumpy car and writhing pain are apparently not friends. Soon, I began to feel like I might throw up. My husband asked if I needed him to pull over, but I assured him I was handing it with 'mind power'. That only lasted so long.Eventually it overcame me and I screeched 'Pull over!!' But it was too late. We couldn't make it. We were on a stretch of road with no shoulder. So, to save the car, my husband sacrificed a prized possession. His hat. Yes, that's right. He took his brand new, football supporting, perfect, highly loved hat from his head and handed it to his writhing in pain wife and said 'Here, use this.' I did.
I promised to buy him a new one. I still haven't.I should probably rectify that.
See? Husbands are wonderful.


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Earlier today, ACItaly uploaded a lengthy video interview with Kunos Simulazioni Staff Member Stefano Casillo discussing the future of Assetto Corsa. Unfortunately for us, the 54 minute interview is spoken entirely Italian.
All is not lost, as some Reddit users have skimmed through the video and translated the main talking points – primarily the additional cars and tracks we can expect to see in Assetto Corsa as the 2015 calendar year comes to a close.
- Dream Pack #3, like the previous two premium DLC packs prior, will feature 10 cars and one new location, the iconic former UK Grand Prix circuit Brands Hatch. The pack will be released near the end of December.
- Version 1.3.5 will come with one free car, the Audi R8.
- Version 1.4 will be released alongside Dream Pack #3.
- While Night Racing will not likely be seen in this version of Assetto Corsa as it would require an entire engine re-write, the team are in the early stages of bringing Rain into Assetto Corsa, most likely seeing a public release a version or two after the game launches on consoles in the spring of 2016.
- Major multiplayer changes are "in the works", but no concrete details have emerged as to what this may mean.
As for the rumored list of cars included in the third premium DLC pack, Reddit user Brains77777 has put together a partial list. I'm inclined to believe what I see here, as the Lotus 25 has already been confirmed by Kunos themselves:
- Lotus 25
- Lotus 72
- McLaren 650s GT3
- Mercedes AMG GT3
- Abarth 500 Assetto Corse
- Ford Escort Mk. 1
Only time will tell how this all pans out. I myself have lost interest in the title, so it's hard for me to gauge whether this pack will be worth the common asking price of $15. Personally, I'm disappointed that this kicks off the start of yet another waiting period, where AC owners aimlessly sit around on message boards to kill time waiting for a major update that's almost six months away.


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The Companion
The Companion is our tri-annual magazine that shares the growth of our mission, stories of our graduate teams and the good work our staff and volunteers are doing. Enjoy the beautiful images and wonderful stories. Together we are changing lives four paws at a time.
Current Issue: Summer Companion 2017
Archive Issues:
Spring Companion 2017
Holiday Companion 2016
Summer Companion 2016
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"I lost my identity that day in the hospital."


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It is getting almost comical watching the destruction of 3rd Congressional Republican candidate Todd Lally implode. Seriously. For months now I have been asking Todd for specifics finally opting to jump off his bandwagon because he just does not get it. He still today less than 6 weeks before the election does not have a plan.
Check out the latest from the CJ: Todd Lally releases jobs plan in bid to unseat John Yarmuth courier-journal.com The Courier-Journal
Great headline with one problem.
Lally has no plan. The CJ even quotes him in their own article as admitting such.
From the article: "Republican House candidate Todd Lally on Monday released a jobs plan that includes small business tax incentives, penalties for shipping jobs overseas, reduced regulation and low taxes he said would boost employment."
Then the Cj goes on to state this:
"Lally said he didn't have any specifics on his small-business tax credit proposal."
Lally is quoted as saying "Seven out of 10 jobs are created by small businesses," Lally said. "Ending the recession means giving small businesses the tax relief they need and not punishing them for being successful."
But he cannot provide specifics on how he will address this? After a year of being in this race?
Folks this is exactly why I left team Lally in the first place. No substance.
That has always been Todd's problem. He likes to speak with party rhetoric but has not, and will not do the work necessary to develop a plan and back up what he preaches.
If he is that lazy now how in the hell will he govern?
In the meantime his Libertarian challenger, ed Martin, has already outlined a specific example of relief for small business and also included specifics on revamping workers comp which is killing small business.
Seems Lally has some serious catching up to do. It also appears the CJ really needs to rethink their headlines.
Lally has no plans to lead with a headline like the one the CJ used is misleading as hell.
Look elsewhere than Todd Lally if you want to move forward folks.
If you can't vote Yarmuth then vote Martin. At least you know what you are getting.
Monday, September 20, 2010
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Thursday, 19 April 2001
David Eddings: The Losers (1992)
Review number: 799
Apart from his debut novel, thriller High Hunt, The Losers is Eddings' only attempt at something outside the fantasy genre. Interestingly, it has aspects in common with the much earlier novel, including the Washington state setting (though that is where Eddings lives) and a plot incorporating ideas about sibling rivalry (less literally here).
Raphael Taylor is bright, good-looking and athletic - a high school American football hero. When he goes to university, he meets the strange but fascinating Damon Flood, and is basically led astray. A drunken driving accident leads to the loss of a leg, and Raphael has to face up to life as a cripple.
Unable to face his friends, Raphael moves to a poor area of Spokane to begin his convalescence, only to become fascinated by the lives of those around him (in a Rear Windows kind of way). These people, living on the edge of crisis, unwillingly dependent on an institutionalised social services, are the losers of the novel's title.
The losers are really what the novel is about, and there are lengthy debates about what drives them and if (and how) they can be helped. A lot of what is said is criticism of the American social services, which, in Taylor's (and presumably Eddings') opinion, fails because it regards these people as a catalogue of problems to be matched against programs, rather than as individuals. It is, of course, an easy criticism to make of any enterprise of a large scale, and it is much more difficult to suggest anything which can
be done about it.
As a novel, The Losers is more interesting than successful, with the traces of arch humour characteristic of Eddings' fantasy novels seeming distinctly out of place. (This is particularly the case as some jokes are repeated word for word.) Raphael is not believable enough to hang the novel on; the loss of his leg has remarkably few psychological effects, and this combines with his role as observer to make him seem too detached from reality. Charles Dickens would have made wonderful characters out of the losers, and Eddings is no Dickens. The Losers is probably Eddings' most ambitious and least successful novel.
Posted by Simon McLeish at 16:45
Labels: American literature, David Eddings, fiction, literary fiction
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University Hospital Translational Laboratory
University Hospital Translational Laboratory
Quinones-Mateu M.E.,University Hospital Translational Laboratory |
Quinones-Mateu M.E.,Case Western Reserve University |
Avila S.,Instituto Nacional Of Enfermedades Respiratorias |
Reyes-Teran G.,Instituto Nacional Of Enfermedades Respiratorias |
Martinez M.A.,Autonomous University of Barcelona
Journal of Clinical Virology | Year: 2014
Population (Sanger) sequencing has been the standard method in basic and clinical DNA sequencing for almost 40 years; however, next-generation (deep) sequencing methodologies are now revolutionizing the field of genomics, and clinical virology is no exception. Deep sequencing is highly efficient, producing an enormous amount of information at low cost in a relatively short period of time. High-throughput sequencing techniques have enabled significant contributions to multiples areas in virology, including virus discovery and metagenomics (viromes), molecular epidemiology, pathogenesis, and studies of how viruses to escape the host immune system and antiviral pressures. In addition, new and more affordable deep sequencing-based assays are now being implemented in clinical laboratories. Here, we review the use of the current deep sequencing platforms in virology, focusing on three of the most studied viruses: human immunodeficiency virus (HIV), hepatitis C virus (HCV), and influenza virus. © 2014 Elsevier B.V.
Kyeyune F.,Clinical Research Laboratories |
Gibson R.M.,University of Western Ontario |
Nanky I.,Clinical Research Laboratories |
Venner C.,University of Western Ontario |
And 17 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2016
Most patients failing antiretroviral treatment in Uganda continue to fail their treatment regimen even if a dominant drug-resistant HIV-1 genotype is not detected. In a recent retrospective study, we observed that approximately 30% of HIV-infected individuals in the Joint Clinical Research Centre (Kampala, Uganda) experienced virologic failure with a susceptible HIV-1 genotype based on standard Sanger sequencing. Selection of minority drug-resistant HIV-1 variants (not detectable by Sanger sequencing) under antiretroviral therapy pressure can lead to a shift in the viral quasispecies distribution, becoming dominant members of the virus population and eventually causing treatment failure. Here, we used a novel HIV-1 genotyping assay based on deep sequencing (DeepGen) to quantify low-level drug-resistant HIV-1 variants in 33 patients failing a first-line antiretroviral treatment regimen in the absence of drug-resistant mutations, as screened by standard population-based Sanger sequencing. Using this sensitive assay, we observed that 64% (21/33) of these individuals had low-frequency (or minority) drug-resistant variants in the intrapatient HIV-1 population, which correlated with treatment failure. Moreover, the presence of these minority HIV-1 variants was associated with higher intrapatient HIV-1 diversity, suggesting a dynamic selection or fading of drug-resistant HIV-1 variants from the viral quasispecies in the presence or absence of drug pressure, respectively. This study identified lowfrequency HIV drug resistance mutations by deep sequencing in Ugandan patients failing antiretroviral treatment but lacking dominant drug resistance mutations as determined by Sanger sequencing methods. We showed that these low-abundance drugresistant viruses could have significant consequences for clinical outcomes, especially if treatment is not modified based on a susceptible HIV-1 genotype by Sanger sequencing. Therefore, we propose to make clinical decisions using more sensitive methods to detect minority HIV-1 variants. © 2016, American Society for Microbiology. All Rights Reserved.
Weber J.,Czech Institute of Organic Chemistry And Biochemistry |
Rose J.D.,Case Western Reserve University |
Vazquez A.C.,Kent State University |
Winner D.,University Hospital Translational Laboratory |
And 5 more authors.
PLoS ONE | Year: 2013
Most studies describing phenotypic resistance to integrase strand transfer inhibitors have analyzed viruses carrying only patient-derived HIV-1 integrase genes (INT-recombinant viruses). However, to date, many of the patients on INSTI-based treatment regimes, such as raltegravir (RAL), elvitegravir (EVG), and dolutegravir (DTG) are infected with multidrug-resistant HIV-1 strains. Here we analyzed the effect of drug resistance mutations in Gag (p2/NCp7/p1/p6), protease (PR), reverse transcriptase (RT), and integrase (IN) coding regions on susceptibility to INSTIs and viral replicative fitness using a novel HIV-1 phenotyping assay. Initial characterization based on site-directed mutant INSTI-resistant viruses confirmed the effect of a series of INSTI mutations on reduced susceptibility to EVG and RAL and viral replicative fitness (0.6% to 99% relative to the HIV-1NL4-3 control). Two sets of recombinant viruses containing a 3,428-bp gag-p2/NCp7/p1/p6/pol-PR/RT/IN (p2-INT) or a 1,088 bp integrase (INT) patient-derived fragment were constructed from plasma samples obtained from 27 virologic failure patients participating in a 48-week dose-ranging study of elvitegravir, GS-US-183-0105. A strong correlation was observed when susceptibility to EVG and RAL was assayed using p2-INT- vs. INT-recombinant viruses (Pearson coefficient correlation 0.869 and 0.918, P<0.0001 for EVG and RAL, respectively), demonstrating that mutations in the protease and RT have limited effect on susceptibility to these INSTIs. On the other hand, the replicative fitness of viruses harboring drug resistance mutations in PR, RT, and IN was generally impaired compared to viruses carrying only INSTI-resistance mutations. Thus, in the absence of drug pressure, drug resistance mutations in the PR and RT contribute to decrease the replicative fitness of the virus already impaired by mutations in the integrase. The use of recombinant viruses containing most or all HIV-1 regions targeted by antiretroviral drugs might be essential to understand the collective effect of epistatic interactions in multidrug-resistant viruses. © 2013 Weber et al.
Gibson R.M.,University Hospital Translational Laboratory |
Weber J.,Czech Institute of Organic Chemistry And Biochemistry |
Winner D.,University Hospital Translational Laboratory |
Miller M.D.,Gilead Sciences Inc. |
And 2 more authors.
PLoS ONE | Year: 2014
The role of HIV-1 minority variants on transmission, pathogenesis, and virologic failure to antiretroviral regimens has been explored; however, most studies of low-level HIV-1 drug-resistant variants have focused in single target regions. Here we used a novel HIV-1 genotypic assay based on deep sequencing, DEEPGEN (Gibson et al 2014 Antimicrob Agents Chemother 58:2167) to simultaneously analyze the presence of minority variants carrying mutations associated with reduced susceptibility to protease (PR), reverse transcriptase (RT), and integrase strand transfer integrase inhibitors (INSTIs), as well as HIV-1 coreceptor tropism. gag-p2/NCp7/p1/p6/ pol-PR/RT/INT and env/C2V3 PCR products were obtained from twelve heavily treatment-experienced patients experiencing virologic failure while participating in a 48-week dose-ranging study of elvitegravir (GS-US-183-0105). Deep sequencing results were compared with (i) virological response to treatment, (ii) genotyping based on population sequencing, (iii) phenotyping data using PhenoSense and VIRALARTS, and (iv) HIV-1 coreceptor tropism based on the phenotypic test VERITROP. Most patients failed the antiretroviral regimen with numerous pre-existing mutations in the PR and RT, and additionally newly acquired INSTI-resistance mutations as determined by population sequencing (mean 9.4, 5.3, and 1.4 PI- RTI-, and INSTI-resistance mutations, respectively). Interestingly, since DEEPGEN allows the accurate detection of amino acid substitutions at frequencies as low as 1% of the population, a series of additional drug resistance mutations were detected by deep sequencing (mean 2.5, 1.5, and 0.9, respectively). The presence of these low-abundance HIV-1 variants was associated with drug susceptibility, replicative fitness, and coreceptor tropism determined using sensitive phenotypic assays, enhancing the overall burden of resistance to all four antiretroviral drug classes. Further longitudinal studies based on deep sequencing tests will help to clarify (i) the potential impact of minority HIV-1 drug resistant variants in response to antiretroviral therapy and (ii) the importance of the detection of HIV minority variants in the clinical practice. © 2014 Gibson et al.
Archer J.,University of Manchester |
Weber J.,Czech Institute of Organic Chemistry And Biochemistry |
Henry K.,Case Western Reserve University |
Winner D.,Case Western Reserve University |
And 8 more authors.
PLoS ONE | Year: 2012
HIV-1 coreceptor tropism assays are required to rule out the presence of CXCR4-tropic (non-R5) viruses prior treatment with CCR5 antagonists. Phenotypic (e.g., Trofile™, Monogram Biosciences) and genotypic (e.g., population sequencing linked to bioinformatic algorithms) assays are the most widely used. Although several next-generation sequencing (NGS) platforms are available, to date all published deep sequencing HIV-1 tropism studies have used the 454™ Life Sciences/Roche platform. In this study, HIV-1 co-receptor usage was predicted for twelve patients scheduled to start a maraviroc-based antiretroviral regimen. The V3 region of the HIV-1 env gene was sequenced using four NGS platforms: 454™, PacBio® RS (Pacific Biosciences), Illumina®, and Ion Torrent™ (Life Technologies). Cross-platform variation was evaluated, including number of reads, read length and error rates. HIV-1 tropism was inferred using Geno2Pheno, Web PSSM, and the 11/24/25 rule and compared with Trofile™ and virologic response to antiretroviral therapy. Error rates related to insertions/deletions (indels) and nucleotide substitutions introduced by the four NGS platforms were low compared to the actual HIV-1 sequence variation. Each platform detected all major virus variants within the HIV-1 population with similar frequencies. Identification of non-R5 viruses was comparable among the four platforms, with minor differences attributable to the algorithms used to infer HIV-1 tropism. All NGS platforms showed similar concordance with virologic response to the maraviroc-based regimen (75% to 80% range depending on the algorithm used), compared to Trofile (80%) and population sequencing (70%). In conclusion, all four NGS platforms were able to detect minority non-R5 variants at comparable levels suggesting that any NGS-based method can be used to predict HIV-1 coreceptor usage. © 2012 Archer et al.
Gibson R.M.,University Hospital Translational Laboratory |
Meyer A.M.,University Hospital Translational Laboratory |
Winner D.,University Hospital Translational Laboratory |
Archer J.,University of Manchester |
And 7 more authors.
Antimicrobial Agents and Chemotherapy | Year: 2014
With 29 individual antiretroviral drugs available from six classes that are approved for the treatment of HIV-1 infection, a combination of different phenotypic and genotypic tests is currently needed to monitor HIV-infected individuals. In this study, we developed a novel HIV-1 genotypic assay based on deep sequencing (DeepGen HIV) to simultaneously assess HIV-1 susceptibilities to all drugs targeting the three viral enzymes and to predict HIV-1 coreceptor tropism. Patient-derived gag-p2/NCp7/p1/p6/ pol-PR/RT/IN- and env-C2V3 PCR products were sequenced using the Ion Torrent Personal Genome Machine. Reads spanning the 3′ end of the Gag, protease (PR), reverse transcriptase (RT), integrase (IN), and V3 regions were extracted, truncated, translated, and assembled for genotype and HIV-1 coreceptor tropism determination. DeepGen HIV consistently detected both minority drug-resistant viruses and non-R5 HIV-1 variants from clinical specimens with viral loads of ≥1,000 copies/ml and from B and non-B subtypes. Additional mutations associated with resistance to PR, RT, and IN inhibitors, previously undetected by standard (Sanger) population sequencing, were reliably identified at frequencies as low as 1%. DeepGen HIV results correlated with phenotypic (original Trofile, 92%; enhanced-sensitivity Trofile assay [ESTA], 80%; TROCAI, 81%; and VeriTrop, 80%) and genotypic (population sequencing/Geno2Pheno with a 10% false-positive rate [FPR], 84%) HIV-1 tropism test results. DeepGen HIV (83%) and Trofile (85%) showed similar concordances with the clinical response following an 8-day course of maraviroc monotherapy (MCT). In summary, this novel all-inclusive HIV-1 genotypic and coreceptor tropism assay, based on deep sequencing of the PR, RT, IN, and V3 regions, permits simultaneous multiplex detection of low-level drug-resistant and/or non-R5 viruses in up to 96 clinical samples. This comprehensive test, the first of its class, will be instrumental in the development of new antiretroviral drugs and, more importantly, will aid in the treatment and management of HIV-infected individuals. Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Gibson R.M.,University Hospital Translational Laboratory |
Schmotzer C.L.,University Hospital Translational Laboratory |
Schmotzer C.L.,Case Western Reserve University |
Quinones-Mateu M.E.,University Hospital Translational Laboratory |
Quinones-Mateu M.E.,Case Western Reserve University
Current Infectious Disease Reports | Year: 2014
Given the extreme variability of the human immunodeficiency virus (HIV) and its ability to replicate as complex viral populations, HIV variants with reduced susceptibility to antiretroviral drugs or with specific coreceptor tropism (CCR5 and/or CXCR4) may be present as minority members of the viral quasispecies. The sensitivity of current HIV genotypic or phenotypic assays is limited, and thus, these tests usually fail to detect low-abundance viral variants. Next-generation (deep) sequencing (NGS) produces an enormous amount of information that allows the detection of minority HIV variants at levels unimaginable using standard Sanger sequencing. NGS technologies continue to evolve, opening new and more affordable opportunities to implement this methodology in clinical laboratories, and HIV is not an exception. The ample use of a battery of more effective antiretroviral drugs, together with careful patient monitoring based on HIV resistance testing, has resulted in HIV-infected patients whose disease is usually well-controlled. The vast majority of adherent patients without detectable resistance become virologically suppressed; however, a subset of these patients with undetectable resistance by standard methods may fail antiretroviral therapy, perhaps due to the presence of minority HIV-resistant variants. Novel NGS-based HIV assays with increased sensitivity for identifying low-level drug resistance and/or coreceptor tropism may play an important role in the success of antiretroviral treatments. © 2014 Springer Science+Business Media.
Virk S.M.,Case Western Reserve University |
Gibson R.M.,University Hospital Translational Laboratory |
Quinones-Mateu M.E.,University Hospital Translational Laboratory |
Quinones-Mateu M.E.,Case Western Reserve University |
Barnholtz-Sloan J.S.,Case Western Reserve University
PLoS ONE | Year: 2015
Glioblastoma (GBM) is an aggressive, malignant brain tumor typically resulting in death of the patient within one year following diagnosis; and those who survive beyond this point usually present with tumor recurrence within two years (5-year survival is 5%). The genetic heterogeneity of GBM has made the molecular characterization of these tumors an area of great interest and has led to identification of molecular subtypes in GBM. The availability of sequencing platforms that are both fast and economical can further the adoption of tumor sequencing in the clinical environment, potentially leading to identification of clinically actionable genetic targets. In this pilot study, comprised of triplet samples of normal blood, primary tumor, and recurrent tumor samples from three patients; we compared the ability of Illumina whole exome sequencing (ExomeSeq) and the Ion AmpliSeq Comprehensive Cancer Panel (CCP) to identify somatic variants in patient-paired primary and recurrent tumor samples. Thirteen genes were found to harbor variants, the majority of which were exclusive to the ExomeSeq data. Surprisingly, only two variants were identified by both platforms and they were located within the PTCH1 and NF1 genes. Although preliminary in nature, this work highlights major differences in variant identification in data generated from the two platforms. Additional studies with larger samples sizes are needed to further explore the differences between these technologies and to enhance our understanding of the clinical utility of panel based platforms in genomic profiling of brain tumors. © 2015 Virk et al.


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Ask the Baker – Kari Haskell of Retro Bakery
JavaCupcake Note: This is the first post in a series titled, "Ask the Baker" featuring interviews with bakers and bakery owners! I met Kari in August of 2009 when my husband and I went on a little vacation to Vegas! Her bakery is charming and her cupcakes are divine! Thank you Kari for doing this… Read More


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For a professional in private practice, the notion of marketing and branding is unfamiliar territory. This is in a similar situation as within any small entrepreneurial company. Yet, this is truly a fundamental aspect of any business. To develop a following requires a brand, and it doesn't matter if you are a doctor, dentist, an accountant, or an attorney. Your personal "brand" is what comes to mind when your "clients" are deciding whether to see you for the first or not.
Now is the time to get real. Branding is about image and perception. Do not claim to not understand the social networks. Muck right in, however with a special eye to product awareness. Hear yourself scream out, Facebook, LinkedIn, Twitter and Google Trends, here I come.
In principal, a brand is a promise of something that will be delivered by you and your practice. This promise comes in a form of quality, an experience, as well as with a certain expectation in mind. Brands that stand for something connect with customers.
Just as you use brands personify your position, status, and identity when you make decisions about which detergent or automobile to buy so do your clients. Give them something to rely on, something they can sink their teeth into, something which enhances their identity with a positive vibe.
Your credentials have much to do with your image in the consumer's mind, so does your office ambiance and the courtesy (or lack of) offered the minute your staff greet the patient/client at the front desk. You may also be the doctor with bad breath or architect who is frequently late for appointments.
Conceptual Personal Branding
Branding is similar to the development of our own personal traits. Our looks, the clothes we wear, our personality, achievements, contacts, experiences and anything else that adds to, or even detracts from, our appeal to others encompasses our own "personal brand."
When branding your own private practice, you have the ability to carefully create a brand position that will appeal to your market and make your profession more successful through broader, or in some cases, very specific appeal. However, brand development requires time, energy, as well as a reasonable budget.
Personal brand positioning is the activity of creating an identity with a distinctive value in the target customer's mind. For instance, when we think of an accomplished defense attorney, the first ones that spring to mind are those who have a reputation for having a high rate of litigation success – or cardiologists who are identified as utterly competent in curing most heart diseases and extending their patients' life span. Essentially that is the position they occupy in your mind whenever you think of them.
Package Yourself As "The" Entity
A sound marketing and branding plan can help make your clients/patients feel confident about your practice. In addition, a sound sustained campaign will help get new ones grow your practice. Doing so requires the following action plan which will help build your name in a professional and unique way that enhances your recognition, trust and confidence in you as a physician, attorney, architect or other licensed professional.
There are several benefits to creating an effective personal brand. These include:
Enhance Your Competitive Edge
By building a strong personal brand you are creating a sense of individuality and "distinctiveness" in the marketplace so that your clients are able to easily differentiate your practice from your competitors.
Make The Big Leap
Your professional brand becomes your authentic personal identity. The goal of personal branding is to create and portray a consistent image of which you are as a person and what you stand for. It's a reflection of you which includes your values, opinions, and beliefs that are determined by what you say do, and how you do it.
Create Awareness
Due to the plethora of similar products and services offered in the marketplace, consumers are now placing more emphasis on brand differentiation when it comes to distinguishing comparable products and services. As a services professional, you have the ability to take control of your identity and influence the perception others will have about you and the services you offer.
Create The Buzz
Effortless business growth can be achieved by exploiting word-of-mouth advertising through clients/patients, as well as various networks that the buzz spreads through. The latter will be produced when your personal brand will connect you with your spheres of influence who will send you referrals and give you testimonials.
The idea is to give people a reason to talk about you in a flattering way which is considered customer-to-customer selling. Your personal brand should be communicated consistently through many channels which will begin to generate the hype and create excitement for your practice.
A case in point: A dentist in an affluent suburb of Montreal has distinguished himself and his practice from other dental offices in the area by having instilled a mission statement that he and his staff abide by vigorously. This includes guests welcomed in a friendly and state-of-the-art facility with a Zen ambiance to guarantee that each patient visit to the office is both relaxing and enjoyable with the most extraordinary care in the dental field.
The attractive Website even includes a 360 degree tour of the premises which is quite impressive. The dentist is renowned for perpetually honing his skills through continuing education and latest techniques, as well as for his high level of patient satisfaction. As a result, it is believed that the majority of new patients come through word-of-mouth.
Generate Profitability In less Time
A highly regarded personal brand offers the advantage of attracting clients/patients in a timely and effortless manner. You will be able to position yourself in the mind of your typical client or patient as the expert of choice. In doing so, you begin to dominate your local market and command higher fees which, consequently, translate to less work and more money – work smarter as opposed to harder.
Establish Celebrity Status
Gain name recognition in your area of expertise in your "customer's" mind. By making a lasting impression you will be well rewarded for your distinctiveness. Trust, respect, and admiration will follow and you will be perceived as an expert the more visible you are to your target audience. As a result, your brand will propel you to the top in your domain.
A specialist physician who has succeeded in becoming a celebrity in his own right is, undoubtedly, the well publicized American Plastic Surgeon Dr. Robert M. Rey. His media appearances, starring role in the reality show Dr. 90210, his public relations savvy, VIP patient testimonials, as well as his exceptionally resourceful Website all speak volumes of his strong personal brand – the ultimate self promoter.
Create & Sustain Brand Online
Begin by crafting a marketing, advertising and publicity campaign that focuses on helping you achieve your vision. Your consistent message should include your credentials, areas of specialization, as well as the ambiance and experience you desire to achieve for each and every client/patient. It is important to note that your local professional practice code of ethics in advertising may have some restrictions in place with regards to the content of your marketing and PR campaign.
The following greatly enhances your personal brand through the image you want to portray.
- Marketing Collateral
Design an attractive yet professional looking logo and develop graphic standards for fonts and branding colors. Design consistent and matching corporate material which comprises your business card, letterhead, envelope, signage, brochures, note pads, newsletters, etc.
- Waiting Room Ambiance
First impressions count and so does comfort and the entire "customer" experience. Avoid being frugal with your image and invest in designing your office and the waiting room in particular to higher standards. This area speaks volumes of you and this includes clean premises.
- Website & Social Networking
Your Website is essentially your online office and marketing presentation. It too conveys a strong message about your brand image. Make certain it is done professionally, free of any clutter, and include the right amount of information and make it effortless to navigate.
- Trained & Courteous Staff
Branding goes beyond design, it also applies to your support staff. Since it's a given that your clients/patients are the lifeblood of your practice, it's not enough to simply take care of them with expert care and advice but also through excellent and courteous office and billing support. You and your staff are part of your brand, therefore choose them carefully, train them as often as possible and keep them motivated to excel.
As for social networking profiles such as LinkedIn, have a presence, don't mix any personal information or photos and keep them current.
Be Multidimensional
You've spent years studying to earn your credentials whilst you learned about your specialization. Once you're ready to apply the knowledge as a self-employed professional, you discover that growing your practice requires you to compete with other offices to get new clients/patients and referrals.
Just as you are prepared to serve them you also have the extra burden of having to deal with self branding and marketing issues – as any competent sole proprietorship should. A sound marketing and branding plan can help you grow your practice by attracting, as well as retaining clients/patients by making them feel confident about you.
Personal brand positioning should convey to your audience about your unique/distinctive advantages over the competition, and while you are serving them, you are keeping your promise of delivering constantly across all points of contact. That's how trustworthy brands are built.
Your views are welcome.
More news and updates on this topic will follow soon. To stay up to date, you may:
- visit James D. Roumeliotis' blog
- learn more about Total Consumer Experience (TCE)
- revisit our News & Views section,
- follow us @dotkite,
- subscribe to our RSS feed.


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Hyderabad: Those who sell gold in emergency situations will now get only Rs. 10000 net after 1st April onwards. This includes one of the amendments made by Central Govt. in Finance Bill. The remaining amount would be credited to the bank accounts of the sellers.
As per the present rules, those who sell gold were getting Rs. 20000 net which has now been reduced to Rs. 10000.
The gold traders say that if 5 persons of a family approach the gold merchant with 20 grams of gold per head and if they get separate amounts, in such a case nothing can be done. This new rule will affect gold business.
–Siasat News


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Growing up in Los Angeles, jeweler Lizzie Mandler had no shortage of creative influences. "I've always been surrounded by artists of all different types and all different fields," she recalled. "I never really thought twice about whether or not L.A. was an appropriate place for me to be as an artist and as someone who works in fashion," she continued. "It's home, but also, it's really refreshing to be detached from the fashion world and to be able to jump in and out as I choose. Jewelry doesn't really have to be part of the fashion world—it can be as much as you want it to be, but it doesn't have to be."
Mandler is speaking to the recent change in the amount of attention the fashion community is paying to her hometown, but also to her own development in fine jewelry. Her line, which shares her name, lays a foundation in simple, handcrafted gold and jewel-accented pieces. The offerings are classic at heart—gold and diamond studs are a staple—but they also have an irreverent modernity. Take, for instance, Rihanna wearing Alber Elbaz' fur-lined pantsuit with her hands literally covered in Mandler's stacked rings at Lanvin's Fall 2014 show. Mandler's pieces can carry real attitude just as easily as they can demonstrate sophistication.
Lizzie Mandler rings / Photo: Courtesy of the designer
Mandler credits this delicate balance to form. "I think what has always attracted me to fine jewelry is that it has an ability to be incredibly timeless, yet very time-specific, which is really unique to the medium," she said. However, it also seems to stem from her own vision and the city in which she works. "I think designers that are based out of LA have a little bit more of a carefree or, excuse my French, but a 'fuck you' attitude," she explains.
Mandler was young when she discovered her passion. "I started non-fine jewelry, basically beaded jewelry, when I was 13, and I worked my way through that world," she said. "When I was in high school—I was 16—I took my first class in fine jewelry. And I remember it was just kind of like, game over. That was it. I knew I had found what I wanted to do."
She continued taking classes at night after school, and when she graduated, she enrolled at USC so she could stay at her jewelry school. "I would go [to jewelry school] after [my academic] classes and go in my office and sit and work and learn," she said. "Like, two days after graduation I filed for my business license. I worked towards my goal the entire time in college, knowing what I really wanted to do."
Now, she creates delicate, diamond-covered yellow and rose gold curving, double finger rings, marquis-shaped emeralds framed with white diamond pave, and black diamond-accented gold crescent studs. These pieces can be found at Dover Street Market, among other retailers.
Lizzie Mandler bracelet and earrings / Photo: Courtesy of the designer
"I feel very honored to do what I do, as cheesy as that sounds," reflected Mandler. "Jewelry becomes the medium for someone to express their love or commemorate a particular time in their life. It's rare that you do that with anything else. It's really rare that your grandmother will pass a jacket down four generations."
These days, she's busy developing her forthcoming collection. This includes refinements on favorite styles—a baguette knife ring, for instance—and the development of new pieces. "One of my goals always is doing classics in ways that are modern, so I'm working on a pair of studs that are going to be a more modern take on a very classic pair of diamond studs," she explained.
"Women are starting to realize that within the space of fine jewelry, it doesn't have to be as sacred as they once felt it was," mused Mandler. "It's not just reserved for a special occasions or an engagement ring. Jewelry is what you make it, so I have no problem wearing a giant pair of diamond earrings and a white t-shirt. I think women are realizing, you don't spend money, or someone doesn't spend money to give you this beautiful piece of jewelry for it to just sit in your jewelry drawer or your safety deposit box. Sometimes jewelry seems untouchable and just so precious, but really, it should be worn."


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All good things must come to an end. That includes Jefferson Forest's volleyball team's win streak.
The Cavaliers continued to roll with a win over Byrd to open up it's week. After a hiccup in the first set, the Cavs rebounded by sweeping the next three sets 25-19, 25-23, 25-23.
JF's gritty performance was highlighted by Bailey Tibbs and Sarah Shanton's nine kills each. Sydney Strain produced seven kills while Gracyn Draney and Kelsey Gerni had four kills a piece.
Staunton River and Liberty had impressive showings at Rush Farm on Aug. 30. Both schools had one first-place finisher at the meet. Rustburg also competed and was the host school of the meet.
Staunton River
The Eagles found gold with Christiana Metric. The freshman logged a 21:26.68 in the 5000 m run to capture first place. Metric's gold medal run was a whopping 24 seconds faster than the second place finisher.
Liberty hosted Jefferson Forest, LCA and Brookville at Bedford CC for the fifth Seminole District match on Aug. 30.
The Cavaliers looked to continue arguably the program's best season with another District win. The Cavs have finished first at every match thus far except the High School Invitational in Midlothian, which featured elite talent from Class 5/6 high schools.
Staunton River's volleyball team continued to show improvement with competitive showings against Heritage and Christiansburg on Aug. 29 and Aug. 31, respectively.
The Eagles began its home stretch against Heritage on Tuesday evening. The young squad had previously faced the Pioneers in its home-opener, where they dropped the contest in three sets, 25-13, 25-21, 25-14.
Liberty's football team manhandled Franklin County to come away with the 33-17 win for its season-opener on Aug. 25.
The Minutemen squashed any doubts or uncertainty that the small, youthful squad stocked of juniors and freshmen would struggle to compete.
Bedford County's football programs were well-represented at the 2017 Titan Trophy Ceremony held at Phase 2 in Lynchburg.
Jefferson Forest, Staunton River and Liberty each had multiple Titan Trophy Team nominees.
The Cavs led with seven Titan Trophy team members (Will Strain, Jon Tobin, O.P. Peterson, Nick Rainey, Chris Peters, Chris Carroll and Brad O'Donnel). The Eagles had four members (T.J. Testor, Grayson Overstreet, Kalip Jones and Joe Haner) and Liberty supplied two (Brock Lucas and Malachi Johnson).
Bedford County's volleyball teams clashed early in the season, with Jefferson Forest and Liberty coming out victorious.
The first County Clash was between the Cavs and the Eagles on Aug. 24 at Jefferson Forest.
Prior to the match, the Cavs had rolled out to a promising 2-0 start, while the Eagles, headed by a first-year head coach, had dropped its season-openner to Heritage.
The Cavs looked to continue to capitalize with their healthy squad against the youthful Eagles (SR's team does not have a senior player).
Jefferson Forest's golf program is now a perfect four-for-four at Seminole District matches.
The powerhouse program notched its sixth win this season at Winton CC against Liberty, Heritage and Amherst.
The Cavs won by 15 strokes, shooting a collective 158 to top Amherst's 173 for first place. Fellow Bedford County high school, Liberty, came third with a notable 207, which is down three strokes from their last outing. Heritage placed fourth with 211.
Staunton River golf played its fifth Blue Ridge District match on Aug. 22 at Blue Hills GC.
The Eagles placed third in the BRD match up, just 12 strokes shy of William Byrd who placed second. Lord
Botetourt, the BRD leaders for the entirety of the season, blew out the competition with a 315.
It was the first BRD match the Eagles had not placed second in. Despite the third place finish, the Eagles still finished second in the rankings behind Botetourt.
In the individual rankings, the Eagles placed three golfers in the top 10.
Coming off a 2-8 season with a team stocked with underclassmen, head coach Chris Watts says his team is still growing. The Minutemen hope to secure a few more wins under their belt and continue gaining experience as the team still boasts mostly younger players. Here's Watts' take on his 2017 squad.
What improvements has your team made since last year?
Copyright © 2017
The Bedford Bulletin is your source for local news, sports, events, and information in Bedford County and Bedford, VA and the surrounding area.


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Balance Noun Synonyms: scale(s), steelyard
Balance Verb Synonyms: weigh, estimate, ponder, consider, deliberate, assess, compare, evaluate
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Previous Noun Synonyms: former, prior, past, earlier, one-time, foregoing, sometime, erstwhile, preceding, quondam, whilom
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Business / Finance / Average Daily Balance: A method for calculating interest in which the balance owed each day by a customer is divided by the number of days. See also: Adjusted balance method and previous balance method. MORE
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Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree
Version of Record online: 20 NOV 2012
DOI: 10.1111/j.2042-3306.2012.00684.x
© 2012 EVJ Ltd
Equine Veterinary Journal
Volume 45, Issue 4, pages 419–426, July 2013
Additional Information
How to Cite
Valberg, S. J., Sponseller, B. T., Hegeman, A. D., Earing, J., Bender, J. B., Martinson, K. L., Patterson, S. E. and Sweetman, L. (2013), Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree. Equine Veterinary Journal, 45: 419–426. doi: 10.1111/j.2042-3306.2012.00684.x
Publication History
- Issue online: 6 JUN 2013
- Version of Record online: 20 NOV 2012
- Accepted manuscript online: 28 SEP 2012 05:45AM EST
- Manuscript Accepted: 21 SEP 2012
- Manuscript Received: 17 JUL 2012
Funded by
- Rapid Agricultural Response Fund
- Abstract
- Article
- References
- Supporting Information
- Cited By
Fig S1: MCPA-glycine spectra. A. Spectrum of diTMS derivative of synthesised MCPA-glycine with molecular ion at m/z 313 and M-15 at m/z 298 with a large m/z 247 typical of diTMS derivatives. B. Spectrum of diTMS derivative of MCPA-glycine from urine of an SPM horse (CL).
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.


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Download Cloud Dinosaur Puzzle for Kids apk 1.0.1 free for Android smartphone
Posted by Wooland Games in Educational | March 24, 2014 | 1 Comments
Apk file size: 18.0 MB
No In-App-Purchases whatsoever! Yay!
Have you ever dazed off looking at clouds and let your imagination run wild? If you have then "Cloud Dinosaur Puzzle for Kids" is the game for you and your kids! "Cloud Dinosaur Puzzle for Kids" is an awesome puzzle game that lets you search for characters in a field of clouds. Be careful, they can be tricky but not too hard! After each session you get to open a present!
Now with an all new sound track and mute function with child lock!
"Cloud Dinosaur Puzzle for Kids" is a colorful, educational game that also reinforces hand-eye coordination and engages children for hours on end with multiple levels. Parents can also join in the fun as well. Interactive games featuring many different dinosaurs and end of scene prizes are waiting to be discovered!
- 12 Dinosaurs that cover major prehistoric periods; Ankylosurus, Brachiosaurus, Diplodocus, Pachycephalosaurus, Parasaurolophus, Plesiosaurus, Pteranodon, Spinosaurus, Spinosaurus, Triceratops, Tyrannosaurus-Rex, and Velociraptor!
- 15 in game levels that feature dynamic cloud puzzles.
- In game actions feature attention grabbing sounds and music now with an all new sound track and mute function with child lock!
- A slider option for parents that hinder kids from accidentally exiting the game.
- HD quality artwork.
- Easy to use and control.
- This educational game will help your kids to improve abilities in problem solving and visual memory and they also can develop their fine motor skills.
- After completing each level kids get to open a present!
- All in game controls are especially tuned for seamless interaction with kids without constant parental supervision.
This App does not require logging into any social networks, nor does it contain any hidden web links or any form of data logging.
Wooland site Privacy Policy:
At Woolandgames your privacy is important to us! None of our games require logging into any social networks, nor do they contain any hidden web links or any form of personal data logging. Also, your personal information is not collected and your location is not stored or shared.
We guarantee that any of the anonymous data that we log to monitor our apps is not shared with advertisement companies.
Wooland Games part of our Educational and have average installs from 1000 to 5000. Last Update March 24, 2014. Google play rating is 53.3333. Current verison is 1.0.1. Actual size 18.0 MB.
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1 Comments
metin gucer
Great App This game is definitely a time killer for my kid. She enjoys playing very much. Specially finding dinosaurs in the cloud is not that easy as it looks.


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We highly value Dr. Rao
Dr Leo is great! Takes time with you! Great sense of humor! Would highly recommend!!!
I am not an easy patient in that I believe the doctor works for me. Dr Leo invests in Me. He understands how I feel and is not put off by it like some doctors. He runs late Always so keep that in mind but that is not a hinderence for me. He is worth the wait. I have been seeing him for many years and he Listens, Cares, and Remembers. Ms. Edith, his nurse is a God send. She is WONDERFUL. Keep him in mind if you are in need. Many of the doctors at the clinic are good but I am partial to mine.
Dr. Oubre is amazing! He is very thorough and takes his time with each patient.
Outstanding credentials and supreme attention to detail. One of the only (if not the only) physician at the LA Endoscopy Center with Fellow status with the American College for Gastroenterology. Although my treatment was routine (colonoscopy on 1-24-17), I was impressed by Dr. Reddy throughout all phases of the day's procedure. Her attentiveness to my condition, as well as her explanation of the procedure, were all exemplary. I highly recommend her!
I've been his patient since 2001. He always friendly and seem genuinely concerned about what problems I'm having.
Dr .Mullins made me feel like I was his only patient ,and him and his staff was amazing !!! Thank you for taking such good care of me and I'm referring my brother to you to have his procedure done .
GREAT GASTRO DOCTOR Crohns patient for 45 yrs A caring, well studied , great listener, and concerned Dr
Shows up an hour past 1st patient scheduled making him 1.5 hours late to see patients. My time is important to me. He is unapologetic for him lateness. His staff is use to his tardiness as this is how he operates. He also prescribed medication that I'm allergic to after I specifically told he and his staff
This doctor is insensitive and uncaring about her patients.
I attended my mother's appointment with Dr. Lobrano yesterday. Dr. Lobrano took the time to answer all of our questions. She explained what she thought the diagnosis could be, how she would determine the diagnosis via tests, and how we should treat my mother's ongoing symptoms until she could determine the diagnosis. Dr. Lobrano took her time with my mother, and I felt she did not rush through the appointment.
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See more group practices in Baton Rouge.
LA, Baton Rouge, LA, 70809
Baton Rouge
Gastroenterology Associates
(225) 927-1190
Gastroenterology Associates
9103 Jefferson Hwy
Dr. Satyaprasad Alapati, MD
Dr. William Anderson III, MD
Dr. Robert Be, MD
Dr. Charles Berggreen, MD
Dr. Jonathon Chapman, MD
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property description
New construction. Occupancy summer 2016. First Fendi residential building Worldwide. Oceanfront 58 Private Flow through residences, 12 story boutique building. Residences delivered decorator ready, with finished Italian bathrooms and Fendi Casa kitchens. Amenities include: Ultra luxury concierge services and Attach?? lifestyle. Amenities: Private gourmet dining wine room, indoor outdoor restaurant,spa,fitness centre,home theatre,kids club,ballroom,business center,full service building.
Exterior Features
- Open Balcony
Interior Features
- Elevator
- Walk-In Closets