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The Love Dare for Parents, LeatherTouch Edition
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The Love Dare for Parents, LeatherTouch Edition
B&H Books / 2014 / Imitation Leather
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Stock No: WW682766
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Product Description▼▲
The Love Dare for Parents applies the same technique used in the popular marriage book, The Love Dare, to parenting, challenging parents to understand, practice, and communicate life-changing Christ-like love to their children. During each of the 40 day journey, parents are given a key verse from Scripture, a biblical principle about love that applies to parenting, and a specific challenge for the parent to do that is done for the sake of their child. You'll also find journaling space for your reflections and a FREE parenting assessment tool is available online. Deluxe Custom Edition.
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|Format: Imitation Leather
Number of Pages: 256
Vendor: B&H Books
Publication Date: 2014
|Dimensions: 8.50 X 5.50 X 0.67 (inches)
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Publisher's Description▼▲
From the authors of international best-selling marriage book The Love Dare comes The Love Dare for Parents, a 40-day journey of "dares" challenging one or both parents to understand, practice, and communicate Christ-like love to their children.
Easy to read and work into a busy schedule, The Love Dare for Parents is designed to "turn the hearts of parents to their children and turn the hearts of children to their parents" (Malachi 4:6) so that moms and dads can more fully enjoy and delight in their children while maximizing the positive impact they have on their lives long term.
Each day brings a promising key verse from Scripture, a biblical principle about love that applies to parenting, a specific challenge the parent does for the sake of their child, and space to journal thoughts and reflect on what happened that day.
The Love Dare for Parents even includes access to a FREE online parenting assessment, helpfully keyed to select material in the book.
Parents, take the dare!
Author Bio▼▲
Stephen Kendrick is an ordained minister who has served families for 20 years in student ministry and associate pastor positions. Along with his brother Alex, he is also a screenwriter (Facing the Giants, Fireproof, Courageous), movie producer, and coauthor of two New York Times best-selling books (The Love Dare, The Resolution for Men). Stephen and his wife, Jill, have six children.
Alex Kendrick is an ordained minister and New York Times best selling coauthor of The Love Dare and The Resolution for Men. He has spoken in numerous countries to students, families, and men's groups. He is also an accomplished actor, screenwriter, and film director, whose credits include Facing the Giants, Fireproof, and Courageous. He and his wife, Christina, have six children.
Alex Kendrick is an ordained minister and New York Times best selling coauthor of The Love Dare and The Resolution for Men. He has spoken in numerous countries to students, families, and men's groups. He is also an accomplished actor, screenwriter, and film director, whose credits include Facing the Giants, Fireproof, and Courageous. He and his wife, Christina, have six children.
Product Reviews▼▲
of customers would recommend this product to a friend.
kircharaAge: 25-34Gender: female1 Stars Out Of 5Judgmental at parents who has fewer kidsFebruary 8, 2016kircharaAge: 25-34Gender: femaleQuality: 2Value: 2Meets Expectations: 1"[Selfishness] leads many parents to refuse to have more children because they don't want anything to stretch them further beyond themselves" (page 28).
Wow. So according to the Kendrick brothers, my husband and I are selfish parents because we have two boys instead of six kids. I did note a judgmental vibe/tone from the writing even before this statement.
You can write a book challenging parents to love their children more without slamming parents who has one or two kids. If some people choose to divide their resources (time, money, etc.) among fewer instead of more kids, that's their prerogative.
promisewer5 Stars Out Of 5Love Dare for ParentsJanuary 8, 2015promisewerQuality: 5Value: 5Meets Expectations: 5I lead this as a Bible study for our ladies group at the request of a young single mom at our church. I had 3-4 women my age --- grandmother age -- who also participated!! I did my best to apply the "dares" to my adult children as did the others my age! Sometimes that was a bit scary, given the fact that I had not done this when my children were younger and now asking them to tell me things as adults that I may not want to hear!! But I must say overall even those of us who had grown children were able to grow spiritually as we listened, applied, advised, mentored those younger than us! I was impressed enough that I gave this book as gifts to my adult children for Christmas to apply to their children now regardless of their ages!!!
SoaringEagleUSAGender: female5 Stars Out Of 5Encouraging/challengingAugust 19, 2014SoaringEagleUSAGender: femaleQuality: 5Value: 5Meets Expectations: 5You have probably heard about the book The Love Dare. It is a 40-day journey for you and/or your spouse to do little things(or big) for the other. Well, we now have one for parents. It's called The Love Dare for Parents by Stephen & Alex Kendrick.
I wanted to review this book and also do the daily challenge for my own children. I needed a fresh look at how precious they truly are. Sometimes I find myself in a rut where it seems we argue too often, especially with my pre-teen. I want to stop that cycle...it's not a fun way to relate to each other.
First you would start with the online assessment. I wasn't surprised with the results, it actually confirmed what I was thinking about the areas that I need help in. The results also tell you which days will be helpful in working on those problem areas.
Day one was easy for me. The challenge was to tell your children that you love them. Saying "I love you" is easy for me. But maybe it isn't for you. Do it anyway. The day starts out with a Bible verse. Then a short message about love and parenting. That day's challenge is next, followed by a journal area to write down what the result was. So far my children have not said anything special about what I have been doing, but they may still be noticing. Keep doing them even if your children are not really responding.
Day 2 was about patience. I need help with that. That challenge was to write Love is Patient and stick it somewhere. I put mine on the fridge. I still forget but then I remember...it's a hard journey but so worth it.
At the end of the book, in the appendix are eight articles such as how to pray for your children, how to find peace with God, etc...
I'm glad that this book is available to all parents, no matter how old your children are. Get yours today.
I received a complimentary copy of this book from the publisher in return for my honest review.
Seasons of GraceAge: 35-44Gender: female5 Stars Out Of 5A Must Read for ParentsAugust 16, 2014Seasons of GraceAge: 35-44Gender: femaleQuality: 5Value: 5Meets Expectations: 5Love Dare for Parents is a 40 day challenge to develop Christ-like love and influence your children. Parenting is not a piece of cake. It takes time, effort, prayer and lots of hard work. This book teaches you about leading your heart not just giving into feelings and emotions.
Each day consists of an opening Scripture, a devotional to read, and ends with a dare to accomplish. At the end of each day, there are questions to ponder and a place to journal your thoughts.
I have not yet completed the whole book, but am working through it. Sometimes, I take several days to accomplish a dare, especially if life is busy or hectic that day. But, I can say, this book is definitely helping me become a better parent, be more aware, attentive, and have an open mind towards my children. It is teaching me better ways to love, lead and listen.
I would highly recommend this book to any parent whose desire is to love their children in a more intentional Christ-like manner.
I was blessed with this book in exchange for my honest opinion. I am not required to give a positive review.
FIDELITYJEFFERSON, WISCONSINAge: 25-34Gender: female5 Stars Out Of 5WONDERFUL EXCEEDS EXPECTATIONS RECOMMENDEDMarch 15, 2014FIDELITYJEFFERSON, WISCONSINAge: 25-34Gender: femaleQuality: 5Value: 5Meets Expectations: 5AMAZING BOOK JUST STARTED IT ! WE HAVE THE STUDY GUIDE TO GO ALONG WITH THE BOOK ABSOLUTELY GREAT ! RECOMMENDED !
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Ok, I have had it!
Here is the u"L"timate "L"arge pig doing a Trip"L"e jump
You won't believe this video of a black pig doing a triple jump. I am sure it's an "L"
Pig doing a Triple jump, Click Here:
I think Jayzonk wishes he could get out of second gear and try that!
The day I jump my beloved L will be the day that pig decides to fly off into the sunset.

subset: commoncrawl


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weird issue: auth check ignoring asterisk
A user in BW 3.5 is assigned one role that has a few auth objects including S_RS_COMP. He is getting an auth failure that we can see in ST01 trace. But the role gives all values seen in the ST01 error....the user master is compared, and the role is generated and green status. This user should NOT get an auth failure, he definitely has all values seen in the failure. Here is the weird thing, when I edit the role to remove the asterisk in RSZCOMPTP and replace with explicit values (OWZ, REP), it works. I can't explain it. If I put it back to *, it fails. Is this a bug? Has anyone else seen something like this?


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Heydar Aliyev Center to host exhibition by renowned Mexican sculptor
Baku – APA. On October 28, Heydar Aliyev Center will host "The Reconstruction of the Being" solo exhibition by renowned Mexican artist and sculptor.
The exhibition will feature monumental sculptures of the artist created in recent years, the Heydar Aliyev Center told APA.
This will be the first exhibit of Jorge Marin in Eastern Europe.
"The Reconstruction of the Being" is built upon three different cores: Men within society, Men in space and Men as a body and as a mind. The name of the exhibition refers to the process of displaying the artist's development and personal deconstruction of a self, and to the posterior reconstruction that happens when spectators are able to interact and live with the sculptures, embodied in the same space, as Jorge Marin's bronzes entwine with the Heydar Aliyev Center's architecture.
53-year-old artist has been working for more than 25 years. After a broad search, he decided to adopt bronze as his own medium of expression, making it a distinctive sign of his art. He has dabbled in various sculptural dimensions, ranging from miniature to monumental, format has exhibited both in Mexico and abroad, which have taken over public spaces.
He has participated in over 250 group and individual exhibits. His work has been exhibited in galleries and museums in France, Spain, Portugal, Turkey, Germany, Belgium, Hungary, Romania, Costa Rica, Panama, El Salvador, Guatemala, Canada, United States, England, Russia, Belgium, Denmark, Latvia, Serbia, Singapore, China, Hong Kong, and Indonesia.
The exhibition opening at the Heydar Aliyev Center will last till March 31, 2017.
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These limited edition prints accompany the Silence and Abundance exhibit
at the Inde/Jacobs gallery. The two pairs of prints continue the artist's interest with the notion of "background"
and "foreground", color "value", and the "democratization of the surface" a belief that "every drawn form
may inherently be equal to produce a 'surface' that negates a focal point, freeing the eye to wander".
The edition of 14 prints and 4 artist's proofs are available for purchase as an individual print, a set of two prints, or a collection of all four prints.
Printed by Erika Blumenfeld, Marfa, TX.


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Office Location(s):
D-1 Sports at Brier Creek
Alan is a graduate from Sacred Heart University where he obtained his Bachelors degree in Human Movement & Exercise physiology before going on to his post graduate work and doctoral degree in physical therapy. He has since gone on to become board certified as a Sport Clinical Specialist through the American Physical Therapy Association in addition to his certifications as a Strength and Conditioning Specialist through the NSCA and Hardstyle Kettlebell instructor. Alan also works as an instructor for Functional Movement Systems, teaching seminars across the country. Alan has worked extensively with high school, collegiate and professional athletes on an individual basis as well as in consulting roles. His clientele include athletes representing the NFL, MLB, MLS and PGA. His current practice is located in Raleigh North Carolina at Triangle Orthopaedics and D1 Sports Traning and Therapy in Brier Creek.
"Being able to access your Orthopedic Urgent Care on a Saturday was a God-send. It was wonderful to avoid an ER. Thank you all so much for being open on Saturdays and after hours, Monday through Friday."
EmergeOrtho of the Triangle. All Rights Reserved. All trademarks and registered trademarks are of their respective companies. | Sitemap
EmergeOrtho complies with applicable Federal civil rights laws and does not discriminate on the basis of race, color, national origin, age, disability, or sex.
EmergeOrtho does not exclude people or treat them differently because of race, color, national origin, age, disability, or sex. Notice of Non-Discrimination | Limited English Proficiency


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Flat cheeks and sad hanging under eyelids (Photo)
Doctor Answers 8
Get an in person facelift consultation
Given the fact that you have already had multiple treatments to "turn back the clock", I wouldn't feel comfortable giving you a recommendation online. You really need to be assessed in person and have a frank conversation as to your desired outcome, and expectations. Schedule a consultation with a board certified plastic surgeon in your area to discuss the best options for your face.
Kouros Azar
Learn more: http://www.azarplasticsurgery.com/plastic-surgery/facelift.cfm
Sad Look
You have a lot of mid-face laxity, which is best treated by a mid-face lift. This will take out the tired, drawn look on your face.
It is best done through a lower blepharoplasty incision. It is not corrected by conventional face lifting. The shape of your eye can be adjusted at the same time.
Mid-face lifting is not carried out by all surgeons. Many try to disguise the problem with volume augmentation. For you lifting the mid-face would be a better option.
Combining Facial Procedures
Yes, it is possible to #combine. In fact, I commonly recommend other procedures to go accompany a facelift, such as blepharoplasty or a midface (cheek) lift, to name a few. The combination of multiple of facial procedures may create an optimal result.
The best procedure approach will be discussed in greater detail during your one-on-one #consultation. I invite you to visit PacificCenterPlasticSurgery.com to view a complete list of surgeries commonly performed.
The first step is to seek a board certified plastic surgeon who is highly trained with your desired procedures. I also encourage you to look at before and after photos of the surgeons actual patients. Also, reading patient reviews of those who have had combined surgeries will be beneficial. Gathering all of this information will help you make a well-informed decision.
Learn more: http://www.pacificcenterplasticsurgery.com/face-procedures-newport-beach/facelift/
You might also like...
Flat cheeks and sad hanging under eyelids
Hi, I have performed facelifts for over 30 years and have performed many minimally, invasive type facelifts. From the photos your cheeks are flat anteriorly (in the front), there is excess fat below the cheeks, jowls are present, the chin is weak, the Eyebrows are low, there is excess skin in the upper eyelids, excess fat bags in the lower eyelids with what looks like over filling of one lower eyelid and tear trough with a dermal filler. These factors combine to create an elongated oval shaped face.
Following the beauty principles outlined in my book on face and body beauty, women look the most feminine, youthful and attractive with heart shaped faces. Heart shaped faces have cheeks that are full and round in the front. Cheek augmentation with a dermal filler or using cheek implants for a permanent enhancement will create full, round cheeks that will feminize the entire face. Liposuction can be used to further shape the cheek area.
When the chin is weak, this creates an imbalance making the nose appear larger, the mid face top heavy and the lower face look short that de-emphasizes the lips and allows early formation of a double chin. Chin augmentation using a chin implant will add projection to the chin creating harmony and balance to the lower face. I have found that placement of a silastic chin implant, through a small curved incision under the chin (also allows excess skin removal) to be very safe, quick and highly effective.
"Jowls" are sagging facial tissues and an indication for some form of a SMAS facelift. The underlying SMAS layer, of the face, must be dissected, lifted, trimmed and re-sutured (not merely folded or suspended with threads or sutures that will not last). The excess skin is then removed and the facelift incisions closed.
My most popular facelift is the minimally invasive, short incision facelift that has all the benefits of more invasive facelifts (traditional, mid-face, deep plane, cheek lift and subperiosteal facelifts) but with these added benefits:
- very small incisions and no incisions extend or are placed within the hair.
- minimal tissue dissection = less bruising and swelling = rapid recovery ( several days instead of weeks or months with the more invasive type facelifts mentioned)
- can be performed in 90 minutes or less, with or without general anesthesia
- no incisions within the hair = no hair loss
- excess fat can be removed
- excess skin removed
- cheeks, chin and jaw line can be augmented with dermal fillers (I prefer Restylane Lyft) or facial implants
- most patients fly back home to parts all over the world in as little as 3 days post-op
I combine facial shaping with every facelift procedure. When jowls are present, these should be done in concert and not alone or separately in order to create a naturally, more attractive face.
The Brows can be lifted with a Brow Lift which will make the eyes appear more "almond shaped" while the lower eyelid fat can be reduced with a lower Blepharoplasty.
Hope this helps.
Learn more: http://www.beverlyhills-plasticsurgery.com/facelift/#sub
Flat cheeks and hanging eyelids - what to do?
Thank you for asking about your correction of your lower lid appearance.
I am so sorry you have had disappointing results from your previous surgery. This is a complex issue and requires a full examination to make any kind of recommendation.
Always see a Board Certified Plastic Surgeon. Best wishes - Elizabeth Morgan MD PHD FACS
Treatment of Flat Cheeks and Sad Hanging Under Eyelids
After multiple procedures there is no way that anyone can advise you on this forum. You need a direct examination by a board certified facial rejuvenation expert who also has access to the operative reports from your previous procedures so an informed decision can be made.
Cheek volume helps support lower lids
Hi Odalie. Sorry to hear about your previous surgery not going well. The best way to know is with an in-person examination to see how your tissue moves and how it changes with different expressions and movement. I do agree that a filler into the cheeks will help your midface and the lid-cheek junction look fuller & smoother; and will provide some support to your lower eyelids-I prefer the product Juvederm Voluma for this. This is a good option if you are interested in avoiding surgery. There isn't a good nonsurgical alternative for the lower lids. They would have a less "sad" look if you have them anchored to the bone-a procedure called a canthopexy. Best wishes,
Learn more: http://www.changeisbeautiful.com/non-surgical-procedures-jacksonville/injectable-fillers
Thank you for your question. The mid face lift, which may be include other surgeries (such as the undereyelid lift) is a more permanent approach to your desired aesthetic while using fillers is a more temporary approach. The most advanced filler is Voluma, which is identified further on my personal page here with the Voluma video. I suggest that you move forward and consult with a board certified facial plastic surgeon to determine if a facelift or a filler is right for you.
Best wishes,
Learn more: http://www.drclevens.com/face
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Posted on
Helpful Tips You Can Use When Searching for a Job
No matter if you are supporting a big family and paying a mortgage or living by yourself in a one room apartment: being unemployed is a scary thing. The following article is full of helpful tips you can use in your search for a job. They will give you an edge and hopefully land you a job soon.
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Go the extra... Read more


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Our Gondola Base is ideal for creating a bespoke mobile retail display using 4 Gridwall Panels which are separately available. The base has a high quality chrome finish and is remarkably durable and long lasting. The unit arrives in 3 sections and requires minimum time and effort to bolt together and to add panels and accessories to it. It is supplied complete with adjustable feet allowing it to be adjusted for uneven flooring.
Accessories such as hooks, shelves and clothing rail arms can be purchased separately to tailor the unit to your requirements. This unit can be used within any retail environment.
1290mm long x 620mm wide
UK mainland - We offer a next day delivery service (excluding Saturday, Sunday and Bank Holidays) between 9am and 5pm. We aim to dispatch most orders placed before 12pm on the same day. Orders may take upto 48 hours for delivery.AM and Saturday deliveries are available at additional charges. Please feel free to inquire. Delivery charges are calculated by weight and are applicable at the checkout once your order is complete.
Remote delivery charges –Deliveries to Ireland, Isle of Man, Channel Isles, Isle of Sicily and the Scottish Isles incur additional surcharges. Please inquire if you are placing an order from these areas.
Returns – There is a handling charge of 15% on all returned goods.
Damages and shortages –All damages or shortages must be notified within 2 days of receiving your orders.
Redelivery charges –All orders need to be signed for and parcels will only be left at alternative addresses if the customer has supplied us with the information. Please advise us the days you are not there to accept deliveries or there will be redelivery charges applied which is 50% in addition to the standard delivery charge paid.We at Trade Lines endeavour to dispatch your orders as quickly and efficiently as possible. However, we cannot be held responsible for late deliveries by the carriers.Thank you for shopping with us.
Counters -Most of our counters are sent via Pallet, please inquire for the relevant delivery charges as per your location. We will quote you our best prices possible. Slatboards – All orders for slatboards are sent via Pallet. It is a cheaper and more convenient method of transporting large quantities of boards. Please ring to find out and we will quote you our best prices possible.


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• 390mm W x 290mm / 15.35" x 11.41"
• Handle: 240mm L (120mm H) / 9.44" (4.72")
• Front Pocket (Small, perforations): 150mm L x 150mm W / 5.9" x 5.9"
• Front Pocket (Large, blind emboss logo): 150mm L x 240mm W / 5.9" x 9.44"
• Inner Pocket (Large): 200mm L x 170 mm W / 7.87" x 6.7"
• Inner Pocket (Small, with pen loop attached): 90mm W x 200mm L / 3.54" x 7.87"
• Inner Pocket (Medium, gold zip): 260mm W x 160mm L / 10.23" x 6.3"
• Strap at shortest length: 660mm L x 37mm W / 25.98" x 1.45"
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The food was amazing! We got the tasting menu and got 10 different dishes between us. This was a great way to sample the food - which was all great!. Would recommend!
1 - 10 of 1,438 reviews
The food was amazing! We got the tasting menu and got 10 different dishes between us. This was a great way to sample the food - which was all great!. Would recommend!
Went to Redd for Sunday brunch. We've been to Redd before. This time it was a beautiful afternoon so we brought our little 8 pound dog to sit in their outside terrace area. The hostess was so condescending -we live on the UES of Manhattan...More
We visited for a birthday outing and weren't disappointed. We ate in the patio on a beautiful fall evening in September. The food was even better than we remembered. Service was excellent with ambiance to match.
Food was great. Waiter was great. We had Halibut and Scallops which were superior. Great location I'd highly recommend it.
Another wonderful meal. The food here is consistently delicious. Fresh, well prepared and interesting, The corn soup was great, both flavorful and rich. As always the chicken is perfectly prepared. Crispy skin, moist meat served on a bed of farro. The duck is another favorite...More
We had lunch at Redd during our visit to Yountville. Their menu had a lot of great options and we enjoyed a great table outside on their patio. The service was wonderful and the waiter helped us select some wonderful entrees. The lettuce wraps were...More
the place is nice the staff friendly but all the sauces where way too salty. the food was tasty but, nothing specal. we sat at the bar since we had no reservations and it was REALLY loud.
We tried our luck without reservations and were thrilled to have been seated immediately. The wait staff was attentive and very polite. I had the gnocchi entree - it was delightful. Light, buttery & fresh. I wish the room was a tad brighter, but not...More
Hot day in Napa. Record heat. We sat outside. This place is a favorite. Love the food. Never made a bad choice. Today I did. For some reason I figured the chef had adapted to the season (summer) and the temperatures (it's hot in summer...More
We had not been here in a while. The last time we found the food excellent, but it was noisy because of the layout. I have a hearing disability which the prior acoustics amplified. Well they remodeled and now I can hear and enjoy the...More
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Home / Hotmail / Cannot display web page – Hotmail error
In the past few days many users have reported seeing a "Cannot display web page" message in place of their Hotmail email account. Thus, instead of the Hotmail inbox with the email messages, an error page is shown in the browser. The Hotmail sign in problem is a recurring issue but this "cannot display web page" message typically comes up after the subscriber has successfully logged into the account.
Problems are not unique to Hotmail. All web based email services like Gmail or Yahoo! Mail occasionally suffer from server outages that leave behind frustrated users. For this reason, I always recommend users set up the Hotmail email account on their computers. FYI, any email program will be able to download and store email from Hotmail.
Anyway, coming back to the Hotmail cannot display web page problem here are a few things I suggest:
The "Cannot display web page" is typically shown when there is a problem in the Internet connection – the transfer speeds are very low or there is simply no active connection. Thus, the problem might with your Internet Service Provider (ISP). However, we should not negate the possibility that sometimes certain scripts on Hotmail might malfunction resulting in this error page being displayed. If the problem is indeed because of Hotmail, there is little you can do to solve it. I advise patience and checking your account after an hour or so.
How do I view a deleted web page?
Is there a way to view a deleted web page - one that is no longer available? Yes there is and the solution is quite simple. [more...]
Google Chrome is wrongly credited of having introduced the Incognito/private browsing mode. This feature was available in the Safari web browser way back in 2005. [more...]


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Claire Prefontaine 10/23/2016
NORTH ATTLEBORO - Claire Prefontaine, 102, of South Washington St., passed away on October 23, 2016. She was the loving wife of the late Bertrand Prefontaine.
Born on June 1, 1914 in St. Roch Sur Richelieu, Canada, daughter of the late Philippe and Marie Bouvier LaFleche.
She lived in North Attleboro most of her life. She leaves 2 daughters; Denise Prefontaine of Boston, MA., Diane Chappel of Mystic, Conn., and her son-in-law Chip Chappel.
She leaves 3 beloved grandchildren; Julian Edlow of Boston; Christopher and wife Amy Chappel of Mystic Conn., and Erin Chappel of Niantic, Conn. She had 6 great-grandchildren who brought her much joy; Brandon, Sade, Gavin, Hayden, Sawyer and Parker.
She was the sister and last surviving sibling of Lucienne Rose and Michael LaFleche of North Attleboro, Paul Emile LaFleche, Margaret Bouvier, Denise Matte, Madeline Perron and Cecile Romano of St. Roch Sur Richelieu and Montreal.
She also leaves many beloved nieces and nephews as well as a loving family of friends.
Claire passed peacefully in her home following a few days of receiving friends and family for conversation.
Claire had her own business as a seamstress and fashion consultant to other businesses. Her daughter says she had many artistic talents including making furniture and painting.
A Mass of Christian burial will be celebrated in her honor on Saturday, October 29, 2016 at 10am in the Sacred Heart Church 58 Church St., North Attleboro, MA., followed by a burial at St. Mary's Cemetery, Towne St., Attleboro Falls.
A celebration of her life will immediately commence at Bella Sarno Ristorante, 555 Kelly Blvd., North Attleboro.
In lieu of flowers donations may be made to The Home for Little Wanderers, Development Department, 10 Guest St. Boston MA. 02135.
Funeral arrangements entrusted to Sperry & McHoul Funeral Home 15 Grove St. North Attleboro, MA.
She has always held a special place in my heart. I am sad to hear of her passing. People like Claire are few and far between. I have a huge amount of respect and admiration for Claire. I feel so fortunate to have known her. I am very sorry for your loss.
Que Dieu Te Benisse
Repose en Paix
Jimmy,Penny,Jeff and Nicole


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Find public sector jobs in local government, charity, education, housing & more
School Finance Assistant
Employer: Reading Borough Council | Schools
- Reference: N/A
- Published on: Thu 28/11/2013 15:31 PM
- Closing on: Mon 09/12/2013 16:00 PM
- Working Pattern: Part Time, Term Time, Permanent
- Hours: 25 hours per week • Term-time but with some holiday time extra days by negotiation (with flexible working pattern to be agreed) • Start date: ASAP
- Salary: RG3 (points 15-21) £16,215 pa, pro rata for part-time hours
- DBS Check: Enhanced
- Location: Katesgrove Primary School
Responsibilities will include:
- assisting the Bursar with day to day financial matters, e.g. orders & payments
- assisting with arranging and collecting money for school trips
- data entry and filing
- human Resources records maintenance.
Skills required include:
- good knowledge of Microsoft office tools particularly Excel
- experience of data entry packages
- good team-working
- knowledge of FMS would be an advantage.
We can offer you:
- an active and exciting work environment
- a supporting and caring team of staff and governors
- a commitment to your continuing professional development to fulfil the role.
Visits to the school are welcomed. Please phone or email Mrs Humphrey, the Bursar on 0118 937 5490, to arrange an informal visit.
Katesgrove Primary School is committed to safeguarding children at all times and applicants must be willing to undergo child protection screening including checks with past employers and the Disclosure & Barring Service, appropriate references and health clearance.
Closing date for applications is 4pm, Monday 9 December 2013 • Interviews will follow shortly afterwards


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Research Topics
Genomes and Genes
Dietmar Vestweber
Affiliation: Max Planck Institute for Molecular Biomedicine
Country: Germany
Detail Information
- Molecular mechanisms that control leukocyte extravasation through endothelial cell contactsD Vestweber
Max Planck Institute of Molecular Biomedicine, Röntgenstr 20, 48149 Munster, Germany
Ernst Schering Found Symp Proc . 2007..They are expressed at endothelial cell contacts and participate in the migration of leukocytes through endothelium and basement membrane...
- Cadherins in tissue architecture and diseaseDietmar Vestweber
Max Planck Institute for Molecular Biomedicine, Röntgenstr 20, 48149, Munster, Germany
J Mol Med (Berl) 93:5-11. 2015..Consequently, mutations in cadherins are the cause of various human pathologies, with cancer representing one of the most prominent examples. ..
- Cortactin regulates the activity of small GTPases and ICAM-1 clustering in endothelium: Implications for the formation of docking structuresDietmar Vestweber
Department for Vascular Cell Biology Max Planck Institute for Molecular Biomedicine M nster, Germany
Tissue Barriers 1:e23862. 2013..Thus, cortactin is essential for the formation of endothelial docking structures as well as for leukocyte adhesion and extravasation...
- Similarities and differences in the regulation of leukocyte extravasation and vascular permeabilityDietmar Vestweber
Max Planck Institute for Molecular Biomedicine, Röntgenstr 20, D 48149, Munster, Germany
Semin Immunopathol 36:177-92. 2014..Recent work elucidating molecular mechanisms that regulate endothelial junctions and thereby leukocyte extravasation and vascular permeability will be discussed. ..
- Relevance of endothelial junctions in leukocyte extravasation and vascular permeabilityDietmar Vestweber
Max Planck Institute of Molecular Biomedicine, Munster, Germany
Ann N Y Acad Sci 1257:184-92. 2012..In addition, recent progress has improved our understanding of the molecular mechanisms that regulate junctional stability, the opening of endothelial junctions during leukocyte extravasation, and the induction of vascular permeability...
- VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formationDietmar Vestweber
Max Planck Institute of Molecular Biomedicine, Röntgenstr 20, D 48149 Munster, Germany
Arterioscler Thromb Vasc Biol 28:223-32. 2008..This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes...
- A new player in lymphocyte homingDietmar Vestweber
Department of Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
Nat Immunol 9:347-8. 2008
- Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major playerDietmar Vestweber
Max Planck Institute of Molecular Biomedicine, Röntgenstrasse 20, Munster, Germany
Trends Cell Biol 19:8-15. 2009..Here, we focus on recent results showing how leukocytes and angiogenic factors regulate endothelial junctions...
- Adhesion and signaling molecules controlling the transmigration of leukocytes through endotheliumDietmar Vestweber
Max Planck Institute of Molecular Biomedicine, Munster, Germany
Immunol Rev 218:178-96. 2007..The various molecular players and the functional steps involved in diapedesis are discussed...
- Control of endothelial barrier function by regulating vascular endothelial-cadherinDietmar Vestweber
Max Planck Institute of Molecular Biomedicine, Munster, Germany
Curr Opin Hematol 17:230-6. 2010..The endothelial barrier also controls the entry of leukocytes into tissue and it is believed that leukocytes target endothelial cell contacts to reach sites of inflammation...
- A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cellsSandra Iden
Institute of Medical Biochemistry, ZMBE, University of Munster, Von Esmarch Str 56, D 48149 Munster, Germany
EMBO Rep 7:1239-46. 2006..They also point to a direct role of a cadherin in the regulation of cell polarity in vertebrates...
- Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivoAndre Broermann
Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
J Exp Med 208:2393-401. 2011..We conclude that the dissociation of VE-PTP from VE-cadherin is indeed required in vivo for the opening of endothelial cell contacts during induction of vascular permeability and leukocyte extravasation...
- VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGFAstrid F Nottebaum
Max Planck Institute of Molecular Biomedicine, Munster, Germany
J Exp Med 205:2929-45. 2008..In conclusion, leukocytes interacting with endothelial cells rapidly dissociate VE-PTP from VE-cadherin, weakening endothelial cell contacts via a mechanism that requires plakoglobin but not beta-catenin...
- CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesisM Gabriele Bixel
Max Planck Institute of Molecular Biomedicine, Roentgenstrasse 20, Munster, Germany
Blood 116:1172-84. 2010..We conclude that CD99 and CD99L2 act independently of PECAM-1 in leukocyte extravasation and cooperate in an independent way to help neutrophils overcome the endothelial basement membrane...
- VE-PTP controls blood vessel development by balancing Tie-2 activityMark Winderlich
Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
J Cell Biol 185:657-71. 2009..We conclude that VE-PTP is required to balance Tie-2 activity and endothelial cell proliferation, thereby controlling blood vessel development and vessel size...
- Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherinFlorian Wessel
Max Planck Institute for Molecular Biomedicine, Munster, Germany
Nat Immunol 15:223-30. 2014..Thus, Tyr685 and Tyr731 of VE-cadherin distinctly and selectively regulate the induction of vascular permeability or leukocyte extravasation. ..
- A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivoM Gabriele Bixel
Institute of Cell Biology, Zentrum für Molekularbiologie der Entzündung ZMBE, Interdisziplinäres Klinisches Forschungszentrum Münster, University of Munster, Munster, Germany
Blood 109:5327-36. 2007..Our results establish CD99L2 as a new endothelial surface protein involved in neutrophil extravasation. In addition, this is the first evidence for a role of CD99 and CD99L2 in the process of leukocyte diapedesis in vivo...
- Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel developmentSebastian Baumer
Max Planck Institute of Molecular Biomedicine, D 48149 Munster, Germany
Blood 107:4754-62. 2006..No signs for enhanced endothelial apoptosis or proliferation were observed. Thus, the activity of VE-PTP is not required for the initial formation of blood vessels, yet it is essential for their maintenance and remodeling...
- Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeabilityDörte Schulte
Department of Vascular Cell Biology, Max Planck Institute of Molecular Biomedicine, Munster, Germany
EMBO J 30:4157-70. 2011..Furthermore, in these tissues, plasticity of the VE-cadherin-catenin complex is central for the leukocyte diapedesis mechanism...
- Mouse CD99 participates in T-cell recruitment into inflamed skinGabriele Bixel
Max Planck Institute of Molecular Biomedicine, Von Esmarch Str 56, D 48149 Munster, Germany
Blood 104:3205-13. 2004..We conclude that mouse CD99 participates in the TEM of lymphocytes and in their recruitment to inflamed skin in vivo. This establishes CD99 as a valid target for interference with cutaneous inflammatory processes...
- Junctional adhesion molecules (JAMs): more molecules with dual functions?Klaus Ebnet
Institute of Cell Biology, ZMBE, University of Munster, 48149 Munster, Germany
J Cell Sci 117:19-29. 2004....
- Migration of immature mouse DC across resting endothelium is mediated by ICAM-2 but independent of beta2-integrins and murine DC-SIGN homologuesKlaus Wethmar
Max Planck Institute for Molecular Biomedicine, Munster, Germany, and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
Eur J Immunol 36:2781-94. 2006..Taken together, this study shows that ICAM-2 strongly supports transmigration of immature DC across resting endothelium by interacting with ligands that are distinct from beta2-integrins and DC-SIGN homologues...
- von Willebrand factor promotes leukocyte extravasationBjörn Petri
Max Planck Institute for Molecular Biomedicine, Munster, Germany
Blood 116:4712-9. 2010..This step could be related to leukocyte diapedesis facilitated by destabilization of the endothelial barrier...
- Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivoRuth Seelige
Max Planck Institute for Molecular Biomedicine, D48149 Munster, Germany
J Immunol 190:892-6. 2013..We conclude that CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes...
- Association of Csk to VE-cadherin and inhibition of cell proliferationUlf Baumeister
Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
EMBO J 24:1686-95. 2005..Our results suggest that the phosphorylated tyrosine residue 685 of VE-cadherin and probably the binding of Csk to this site are involved in inhibition of cell growth triggered by cell density...
- Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formationNina Dartsch
Max Planck Institute for Molecular Biomedicine, Munster, Germany
Mol Cell Biol 34:1634-48. 2014..Thus, stabilizing endothelial cell contacts by a covalent link between VE-cadherin and α-catenin affects recruitment of hematopoietic progenitors into the fetal liver and the development of lymph but not blood vessels. ..
- Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivityBehzad Kharabi Masouleh
Department of Gynecology and Obstetrics, Medical Center, University of Munster, Munster, Germany
J Immunol 182:4985-93. 2009..Collectively, our results show an important role of syndecan-1 in the contact DTH reaction, identifying syndecan-1 as a novel target in anti-inflammatory therapy...
- Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domainsDaniela Rehder
Institute of Cell Biology, ZMBE, University of Munster, D 48149 Munster, Germany
Exp Cell Res 312:3389-403. 2006..Together our findings suggest an important role for JAM-A in the development of apico-basal polarity in epithelial cells and identify regions in JAM-A which are critical for this role...
- Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporterYvonne Helmus
Max Planck Institute of Molecular Biomedicine and Institute of Cell Biology, ZMBE, University of Munster, Von Esmarch Strasse 56, 48149 Munster, Germany
Blood 107:3959-66. 2006....
- ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeabilityFrank Wegmann
Max Planck Institute for Molecular Biomedicine and Institute of Cell Biology, University of Munster, D 48149 Munster, Germany
J Exp Med 203:1671-7. 2006..Collectively, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts...
- Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherinMaike Frye
Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
J Exp Med 212:2267-87. 2015..In the absence of Tie-2, however, VE-PTP inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin-supportive effect of VE-PTP. ..
- Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopeniaCarina Hillgruber
Department of Dermatology and Department of Medicine A Hematology and Oncology, University Hospital of Münster and Interdisciplinary Center for Clinical Research IZKF, University of Munster, 48149 Munster, Germany Department of Dermatology and Department of Medicine A Hematology and Oncology, University Hospital of Münster and Interdisciplinary Center for Clinical Research IZKF, University of Munster, 48149 Munster, Germany
J Exp Med 212:1255-66. 2015..We conclude that specifically targeting neutrophil diapedesis through the endothelial barrier may represent a new therapeutic avenue to prevent fatal bleeding in immune-thrombocytopenic patients. ..
- Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivoMichael Schnoor
Max Planck Institute for Molecular Biomedicine, D 48149 Munster, Germany
J Exp Med 208:1721-35. 2011..Our results represent the first physiological evidence that cortactin is crucial for orchestrating the molecular events leading to proper endothelial barrier function and leukocyte recruitment in vivo...
- How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherinMatthias Vockel
Max Planck Institute for Molecular Biomedicine, Munster, Germany
Blood 122:2512-22. 2013..We suggest that lymphocyte binding to vascular cell adhesion molecule 1 triggers a signaling process that enables a VE-PTP substrate to dissociate VE-PTP from VE-cadherin, thereby facilitating efficient transmigration. ..
- Spatial regulation of VEGF receptor endocytosis in angiogenesisMasanori Nakayama
Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis, and University of Muenster, Faculty of Medicine, D 48149 Muenster, Germany
Nat Cell Biol 15:249-60. 2013..Our work uncovers how vessel growth is dynamically controlled by local VEGF receptor endocytosis and the activity of cell polarity proteins...
- Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivoStephan Seeliger
Department of Pediatrics, University of Munster, Munster, Germany
FASEB J 17:1871-85. 2003..Thus, PAR-2 may be a beneficial therapeutic target for the treatment of inflammatory skin diseases...
- Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa BJörg Buddenkotte
Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University of Munster, Munster, Germany
J Invest Dermatol 124:38-45. 2005..Thus, PAR2 may play an important regulatory role of human KTC during inflammation and immune response...
- Nano-surgery at the leukocyte-endothelial docking siteChristoph Riethmuller
Institute of Physiology II, University of Munster, Robert Koch Strasse 27 b, 48149 Munster, Germany
Pflugers Arch 456:71-81. 2008..Moreover, there were no cases of phagocytotic engulfment, but instead the formation of a transmigratory channel could be observed...
- VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contactsRoman Nawroth
Max Planck Institute for Vascular Biology, D 48149 Munster, Germany
EMBO J 21:4885-95. 2002..Thus, VE-PTP is a transmembrane binding partner of VE-cadherin that associates through an extracellular domain and reduces the tyrosine phosphorylation of VE-cadherin and cell layer permeability independently of its enzymatic activity...
- Integrin β1 controls VE-cadherin localization and blood vessel stabilityHiroyuki Yamamoto
1 Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D 48149 Munster, Germany 2 Faculty of Medicine, University of Munster, Röntgenstrasse 20, D 48149 Munster, Germany
Nat Commun 6:6429. 2015..The sum of our findings establishes that integrin β1 has critical functions in the growing and maturing vasculature, and is required for the formation of stable, non-leaky blood vessels. ..
- The alpha (1,3)-fucosyltransferase Fuc-TIV, but not Fuc-TVII, generates sialyl Lewis X-like epitopes preferentially on glycolipidsMin Chuan Huang
Institute of Cell Biology, Center for Molecular Biology of Inflammation, University of Münster and the Max Planck Institute of Vascular Biology, D 48149 Munster, Germany
J Biol Chem 277:47786-95. 2002..Interestingly, the non-catalytic portion of Fuc-TIV in a Fuc-TIV/VII chimeric enzyme mediated the specificity for glycolipid substrates...
- Blocking von Willebrand factor for treatment of cutaneous inflammationCarina Hillgruber
1 Department of Dermatology, University Hospital of Munster, Munster, Germany 2 Interdisciplinary Center for Clinical Research IZKF, University of Munster, Munster, Germany
J Invest Dermatol 134:77-86. 2014..Of particular importance, anti-VWF treatment was effective both in prophylactic and therapeutic administration. Thus, VWF represents a promising target for the treatment of cutaneous inflammation, e.g., leukocytoclastic vasculitis. ..
- Lymphocyte trafficking through blood and lymphatic vessels: more than just selectins, chemokines and integrinsDietmar Vestweber
Max Planck Institute of Vascular Biology and Institute of Cell Biology, ZMBE, University of Munster, Munster, Germany
Eur J Immunol 33:1361-4. 2003
- Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammationAlexander Zarbock
Department of Anesthesiology and Intensive Care Medicine, University of Munster, Albert Schweitzer Strasse 33, Munster, Germany
J Mol Med (Berl) 90:353-9. 2012..Further investigation of this new mechanism may allow providing new approaches for the development of the next generation of anti-inflammatory drugs...
- Characterization of the inflammatory infiltrate and expression of endothelial cell adhesion molecules in lupus erythematosus tumidusAnnegret Kuhn
Institute of Cell Biology, ZMBE, Westfalische Wilhelms University, Munster, Germany
Arch Dermatol Res 294:6-13. 2002..Furthermore, expression of endothelial cell adhesion molecules was equally upregulated in LET compared with the expression in DLE and SCLE, suggesting a similar immunopathomechanism of these subtypes of CLE...
- Leukocyte adhesion deficiency II: therapy and genetic defectMartin K Wild
Institut fur Zellbiologie, Zentrum fur Molekularbiologie der Entzundung, Universitat Munster, Munster, Germany
Cells Tissues Organs 172:161-73. 2002..Thus, LAD II represents the first developmental and immune defect that is based on a malfunctioning nucleotide sugar transporter...
- Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailabilitySusana F Rocha
From the Max Planck Institute for Molecular Biomedicine, Munster, Germany S F R, M S, D J, H L, S B, D V, D B, H C A D, S A, R B, R H A University of Münster, Munster, Germany R H A Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain S F R, R B and Neurochirurgische Klinik, Charite Universitatsmedizin, Berlin, Germany M N K, P V
Circ Res 115:581-90. 2014..Endothelial cell-specific molecule 1 (Esm1) is a secreted protein thought to play a role in angiogenesis and inflammation. However, there is currently no direct in vivo evidence supporting a function of Esm1 in either of these processes...
- Phosphatases and kinases as regulators of the endothelial barrier functionVerena Küppers
Max Planck Institute for Molecular Biomedicine, Röntgenstr 20, 48149, Munster, Germany
Cell Tissue Res 355:577-86. 2014..In particular, the role of the endothelial specific phosphatase VE-PTP in the context of endothelial cell contact stability will be highlighted. ..
- GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimerAnnette Artz
Max Planck Institute for Molecular Biomedicine, Munster, Germany
Blood 128:529-41. 2016..This represents a novel, rapid anti-inflammatory activity of the 2 TGF-β receptors and of TGF-β1. ..
- A transmembrane tight junction protein selectively expressed on endothelial cells and plateletsInes Nasdala
Institute of Cell Biology, ZMBE, University of Munster, 48149 Munster, Germany
J Biol Chem 277:16294-303. 2002..The 1G8 antigen supports homophilic interactions on transfected Chinese hamster ovary cells. Based on the similarity to the JAM molecules, it is plausible that the 1G8 antigen might be involved in interendothelial cell adhesion...
- HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1Joanna Latasiewicz
Department for Vascular Cell Biology, Max Planck Institute for Molecular Biomedicine, Munster, Germany and
J Leukoc Biol . 2017..Importantly, with the use of Rac1 KO neutrophils, we could show that Rac1 acts upstream of Rap1. Our results establish HS1 as an important regulator of proper Rac1 and Rap1 activation and neutrophil extravasation...
- VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cellsTilman Schneider-Hohendorf
Department of Neurology Department of Anaesthesiology, Intensive Care and Pain Medicine Institute for Medical Physics and Biophysics Institute of Neuropathology and Institute of Physiological Chemistry and Pathobiochemistry, University of Munster, 48149 Munster, Germany
J Exp Med 211:1833-46. 2014....
- Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1Gunther G Pendl
Institute of Cell Biology, ZMBE, University of Munster, Von Esmarch Strasse 56, D 48149 Munster, Germany
Blood 99:946-56. 2002..Thus, fucosylated ligands of the endothelial selectins, determined in part by Fuc-TIV, and independent of PSGL-1, are required for extravasation of DCs into sites of cutaneous inflammation...
- Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivityAgatha Schwarz
Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Munster, Von Esmarchstrasse 58, D 48149 Munster, Germany
J Immunol 172:1036-43. 2004..v. injection, because they obviously do not migrate into the skin...
- Novel insights into leukocyte extravasationDietmar Vestweber
Department of Vascular Cell Biology, Max Planck Institute of Molecular Biomedicine, Munster, North Rhine Westphalia, Germany
Curr Opin Hematol 19:212-7. 2012..This review will highlight recent findings that define new regulatory mechanisms and novel activities in the process of leukocyte docking to the endothelium and diapedesis of leukocytes through the endothelial barrier of the vessel wall...
- Molecular mechanisms involved in lymphocyte recruitment in inflamed brain microvessels: critical roles for P-selectin glycoprotein ligand-1 and heterotrimeric G(i)-linked receptorsLaura Piccio
Department of Pathology, University of Verona, Verona, Italy
J Immunol 168:1940-9. 2002..In conclusion, our data unveils the molecular mechanisms controlling the recruitment of autoreactive lymphocytes in inflamed cerebral vessels and suggest new insights into the pathogenesis of autoimmune inflammatory diseases of the CNS...
- PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrinYoshio Katayama
Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1079, New York, NY 10029
Blood 102:2060-7. 2003..Our results thus underscore a major difference between mature myeloid cells and immature stem/progenitor cells in that E-selectin ligands cooperate with alpha4 integrin rather than P-selectin ligands...
- Platelets secrete stromal cell-derived factor 1alpha and recruit bone marrow-derived progenitor cells to arterial thrombi in vivoSteffen Massberg
Deutsches Herzzentrum and Medizinische Klinik, Technical University of Munich, D 80636 Munich, Germany
J Exp Med 203:1221-33. 2006..These findings establish the platelet as a major player in the initiation of vascular remodeling, a process of fundamental importance for vascular repair and pathological remodeling after vascular injury...
- P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 miceBritta Engelhardt
Theodor Kocher Institute, University of Bern, Freiestrasse 1, CH 3012 Bern, Switzerland
J Immunol 175:1267-75. 2005..Taken together, our findings demonstrate that PSGL-1 is not required for the pathogenesis of EAE...
- Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contactsFrank Wegmann
Institute of Cell Biology, ZMBE, University of Muenster, 48149 Muenster, Germany
Exp Cell Res 300:121-33. 2004..In CHO cells, recruitment of MAGI-1 to cell contacts required the presence of ESAM. Hence, ESAM may be involved in anchoring MAGI-1 at endothelial tight junctions...
- Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph nodeFriederike Pfeiffer
Theodor Kocher Institute, University of Bern, Bern, Switzerland
Eur J Immunol 38:2142-55. 2008....
- Platelet-induced differentiation of endothelial progenitor cellsHarald F Langer
Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Tubingen, Germany
Semin Thromb Hemost 33:136-43. 2007..The described interaction of EPCs with platelets represents a novel mechanism of vascular remodeling and healing of endothelial lesions...
- Functionally specialized junctions between endothelial cells of lymphatic vesselsPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 204:2349-62. 2007..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
- Phosphorylation of vascular endothelial cadherin controls lymphocyte emigrationPatric Turowski
Division of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
J Cell Sci 121:29-37. 2008..Taken together, these results demonstrate that phosphorylation of adherens junctions constitutes a molecular endpoint of lymphocyte-induced vascular EC signaling and may be exploited as a new target of anti-inflammatory therapies...
- Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammationDavid Frommhold
Children s Hospital, University of Heidelberg, 69120 Heidelberg, Germany
J Exp Med 205:1435-46. 2008..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo...
- Regulation of endothelial cell contacts during leukocyte extravasationDietmar Vestweber
Max Planck Institute of Vascular Biology, Institute of Cell Biology, ZMBE University of Münster, Von Esmarch Strasse 56, D 48149 Muenster, Germany
Curr Opin Cell Biol 14:587-93. 2002..Progress has been made in identifying novel membrane proteins at endothelial cell contacts as well as novel mechanisms that control interendothelial adhesiveness and transendothelial migration of leukocytes...
- Leukocyte rolling is exclusively mediated by P-selectinin colonic venulesMing Xiu Wan
Department of Surgery, Malmo University Hospital, Lund University, 20502 Malmo, Sweden
Br J Pharmacol 135:1749-56. 2002..Thus, these findings suggest that P-selectin may be a key target to reduce pathological recruitment of inflammatory cells in the colon...
- Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitroJennifer R Allport
Vascular Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
J Leukoc Biol 71:821-8. 2002..These results indicate that although neutrophil proteases may play a role in the acute inflammatory response, neutrophil elastase or MMP-9 is not essential for neutrophil transendothelial migration in this murine system...
- In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endotheliumMaaike Everts
Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration, Groningen, The Netherlands
Pharm Res 20:64-72. 2003....
- Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivoJanine M Prince
School of Biological Sciences, University of Manchester, Oxford Road, Manchester, United Kingdom
Dev Dyn 223:497-516. 2002..This finding may provide a novel dynamic mechanism for inhibiting the transduction of extracellular matrix survival signals, thereby contributing to the onset of apoptosis in a developmental context in vivo...
- Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitopeUlrike Samulowitz
Institute of Cell Biology, ZMBE, University of Munster, Germany
Am J Pathol 160:1669-81. 2002..We conclude that human and mouse endomucin are endothelial sialomucins with the potential to function as L-selectin ligands...
- The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarityKlaus Ebnet
Institute of Cell Biology, ZMBE, University of Munster, Germany
J Cell Sci 116:3879-91. 2003..Our findings suggest that JAM-2 affects endothelial cell junctions by its regulated clustering at intercellular contacts, and they support a role for JAM-2, and possibly JAM-3, in tight junction formation of endothelial cells...
- Multistep nature of microvascular recruitment of ex vivo-expanded embryonic endothelial progenitor cells during tumor angiogenesisPeter Vajkoczy
Department of Neurosurgery, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
J Exp Med 197:1755-65. 2003..This paper provides the first in vivo insights into the mechanisms of endothelial progenitor cell recruitment and, thus, indicates novel ways to interfere with pathological neovascularization...
- Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartmentValery Combes
Experimental Parasitology Unit, Faculty of Medicine, Institut Federatif de Recherche 48, Universite de la Mediterranee, Marseille Cedex, France
Am J Pathol 164:781-6. 2004..These results indicate that endothelial P-selectin plays an important role in the pathogenesis of cerebral malaria...
- A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactionsRenata C O Zanardo
Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1
Blood 104:3766-73. 2004..In conclusion, E-selectin mediates PSGL-1-dependent and independent rolling and the latter can be down-regulated by systemic activation and can replace PSGL-1 to support the development of inflammation...
- E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL miceAxinia Döring
Theodor Kocher Institute, University of Bern, Bern, Switzerland
J Immunol 179:8470-9. 2007..Thus, E- and P-selectin are not required for leukocyte recruitment across the BBB and the development of EAE in C57BL/6 and in SJL mice...
- A novel gene expression profile in lymphatics associated with tumor growth and nodal metastasisSteven Clasper
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom
Cancer Res 68:7293-303. 2008..These findings reveal a remarkable degree of phenotypic plasticity in cancer lymphatics and provide new insight into the processes of lymphatic invasion and lymph node metastasis...
- Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contactsPipsa Saharinen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
Nat Cell Biol 10:527-37. 2008..This novel type of cellular microenvironment-dependent receptor tyrosine kinase activation may explain some of the effects of angiopoietins in angiogenesis and vessel stabilization...
- Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signalingMyriam Labelle
Institute of Pathology, University of Dresden, Dresden, Germany
Cancer Res 68:1388-97. 2008..Our findings may have important implications for the clinical application of anti-VE-cadherin strategies...
- Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor-deficient miceEva J A van Wanrooij
Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, PO Box 9502, 2300 RA Leiden, The Netherlands
Cardiovasc Res 78:590-6. 2008..The aim of the present study is to show the role of CD99 in atherosclerosis using a CD99 vaccination protocol to block the function of CD99 during atherosclerosis...
- Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44Andres Hidalgo
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunity 26:477-89. 2007..These results suggest distinct and dynamic contributions of these three glycoproteins in selectin-mediated neutrophil adhesion and signaling...
- Synthetic glycopeptides from the E-selectin ligand 1 with varied sialyl Lewis(x) structure as cell-adhesion inhibitors of E-selectinChristian Filser
Institut fur Organische Chemie, Johannes Gutenberg Universitat Mainz, Duesbergweg 10 14, 55128 Mainz, Germany
Angew Chem Int Ed Engl 46:2108-11. 2007
- Golgi GDP-fucose transporter-deficient mice mimic congenital disorder of glycosylation IIc/leukocyte adhesion deficiency IIChristina C Hellbusch
Department of Pediatrics, Division of Inborn Metabolic Diseases, Section of Neonatology, University Children s Hospital, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
J Biol Chem 282:10762-72. 2007..The diversity of these phenotypic aspects demonstrates the broad general impact of fucosylation in the mammalian organism...
- Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarctionDavy Vanhoutte
Experimental and Molecular Cardiology CARIM, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Circulation 115:475-82. 2007..The present study investigated whether Synd1 may also regulate cardiac inflammation, matrix remodeling, and function after myocardial infarction (MI)...
- Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitroHarald Langer
Medizinische Klinik III, Eberhard Karls Universitat Tubingen, Germany
Circ Res 98:e2-10. 2006..We conclude that platelets may play a critical part in the capture and subsequent differentiation of murine eEPCs at sites of vascular lesions, revealing a possible new role of platelets in neoendothelization after vascular injury...
- Interleukin-6 is a direct mediator of T cell migrationManuela Weissenbach
Department of Biochemistry, RWTH Aachen, Aachen, Germany
Eur J Immunol 34:2895-906. 2004..Selective activation of the JAK/STAT or the MAPK cascade by mutated receptor proteins shows a crucial role of IL-6-initiated SH2 domain-containing tyrosine phosphatase 2/MAPK activity for migration...
- Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172Petr Bartik
Département de Pharmacologie et Physicochimie, UMR 7175 CNRS, Université Louis Pasteur Strasbourg I, Faculte de Pharmacie, BP 60024, 67401 Illkirch, France
Int J Oncol 32:1021-31. 2008..In addition, beta1-A172 cells exhibited increased matrix dependence for normal cell cycling. Collectively, the data add new evidence for the role of beta1 glycosylation/sialylation in the regulation of integrin functions...


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The latest music update of Hindi movie Gunday is now available in Saavnpk.com. This movie is directed by well known director Ali Abbas Zafar, starring Ranveer Singh, Arjun Kapoor, Priyanka Chopra, Irrfan Khan and music directed by Sohail Sen. All the songs of this audio album are high quality format with highest suitable mp3 bitrate. You can now direct download all the songs of Gunday audio album for free.
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Contribute Your Best Work For The AIRS Community
How can you become an AIRS contributor?
To become a regular contributor at AIRS, here are some tips that will help you to get your article accepted and published:
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I bought the candy corn before Halloween, but I never got around to getting it into the pumpkin candy dish! Will it last until Thanksgiving Day? My son says he doesn't like candy corn, but my husband does! We'll see!
Ya'll Come Back!
I Heart The French Muse
6 hours ago


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Hello there dear neighbors ! I hope life is treating you well. I have to tell you that I have had … More
Tag: rice flour
gluten-free, starch-free banana nut bread
My adorable husband has quickly adapted to my new situation as a dependent woman. Making the bed, doing the house … More
gluten-free and starch-free marble cake
Gardening has taken me away from almost everything these last two weeks. No blogging, no piano, practically no reading, and … More
sulfite-free, gluten-free, starch-free, all natural teff flour bread
The more I use teff flour, the more I like it. Thanks to its incredible properties I am happy to … More
four-layer raspberry and cream cake, gluten free and dairy free
Pastry making should be a mandatory school subject ! It involves chemistry, math, art, some equipment, patience… But above all there … More
failed attempt at gluten-free baking #1: the choux pastry disaster
Hello, neighbors ! This post must come to you as a surprise ; I mean, who wants to look at pictures of … More
stocking up on pear sauce for future gluten-free and dairy-free crêpes (and how to make them!)
Soon pears will not be in season in our part of the globe ; so now is the time to stock … More


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8th Annual Waste Management Middle East Forum will have a focus on "waste-to-value". The focus will be on environmental - friendly treatment capacities in addition to technologies what is already in place today.
Remember the dead – Fight for the living
World Day for Safety and Health at Work or Workers' Memorial Day has been celebrated every ...
World Day for Safety and Health at Work or Workers' Memorial Day has been celebrated every year on the 28th of April since 1970, when the American Federation of Labor and Congress of Industrial Organizations declared it as a day of remembrance and action for workers killed, disabled, injured or made unwell by their work.
According to the International Labour Association's estimates, every year around 2.3 million workers die from occupational accidents and work-related diseases and 313 million workers suffer non-fatal injuries. This accounts for about 6,400 deaths every day!
And it is not only physical harm that raises concern. This year, "Workplace Stress: a collective challenge" is the theme of the campaign. Over 400,000 people suffer from stress-related illnesses caused by their work every year.
The European survey of enterprises on new and emerging risks has published a study on the topic of workplace H&S that shows that in the 28 EU member countries plus Albania, Iceland, Montenegro, the Former Yugoslav Republic of Macedonia, Serbia, Turkey, Norway and Switzerland:
- Formal policies are more frequent in larger organisations
- Along with accidents and musculoskeletal disorders (MSDs), work-related stress is the principal OSH concern for European enterprises
- Only about half of the respondents inform employees about psychosocial risks deriving from their job
- Psychosocial risk factors are perceived as more challenging than other risks; almost one in five of those establishments reported dealing with difficult customers or experiencing time pressure that also leads to stress
Therefore, it is vital that this day is used not only for remembrance but also for campaigning and raising awareness on occupational safety and health.
Do you use this day for raising awareness about occupational health and safety at your company? Tell us about it #IWMD16
Become part of the HSE Excellence Europe
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Heavy Transport, Lifting & Shipping
Learn about the best practices to ensure effectiveness and safety when performing heavy lifts and transporting oversized loads.
NEBOSH International Technical Certificate in Oil and Gas Operational Safety
Operational Safety covers the principles of process safety management in the oil and gas industries, it provides an excellent foundation in health and safety allowing those within the oil and gas industries to manage oil and gas operational risks effectively.
More articles
The State of Waste Management - A GCC Perspective
Due to the unprecedented economic success of the GCC region, the region has attracted many non- resident professionals who have become a part of their growth story. However, this unprecedented surge in population has lead to many issues, one of which is that of waste management. Discover the challenges that are faced by the countries in the region and the policies that are being adopted to address the situation in this report.
A Case Study on a Cogeneration Plant Utilizing Paper Residues in Çorlu,Turkey
A case study on the recycling of paper by products to process fuel at a cogeneration plant in Turkey by our associate sponsor Outotec.
Bridging the gap: Interview with Faisal Ali Rashid, Supreme Council of Energy
Faisal Ali Rashid, U.A.E national is a degree holder of Bachelor of Science in Mechanical Engineering from Dayton, Ohio university, U.S.A. He is currently associated with Dubai's Supreme Council of Energy as Director, Demand Side Management and handling the whole energy demand management spectrum of emirate of Dubai. Mr Rashid highlights the different ways in which the water demand- supply gap is being addressed in UAE:


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LAPD: Woman Posing As Event Planner Targeting LA-Area Party Stores With Fake Checks
Store owners say the woman gave a fake name and paid with fraudulent checks.
The owner of Badia Design in North Hollywood says the woman stole $13,000 worth of centerpieces from his store in February. Since then, police believe she has hit two other places -- Mosaik in LA and Moroccan Party Rentals in Van Nuys.
Surveillance photos captured at Mosaik show the woman and a man she says is her husband inside the store.
Owners say she posed as an event planner needing decorations for a wedding, and then paid the rental fee with a fake check.
The suspect's latest victim is Nelly Bouzaglou from Moroccan Party Rentals.
She says a woman scheduled a last minute appointment to rent $4,000 worth in supplies including candelabra centerpieces and a Moroccan carriage.
She says the woman seemed normal at first, but began acting strange when she started to ask more questions.
Bouzaglou says she went to the bank to cash the check right after the woman left and found out the account was closed.
If you have seen the woman in the surveillance photos or have any information contact the Los Angeles Police Department.
Copyright 2015 FOX 11 Los Angeles | Download our mobile app for breaking news alerts | Follow us on Facebook, Twitter and YouTube.


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TubesMIX for PocketPC 1.2
TubesMIX for PocketPC 1.2TubesMIX for PocketPC - TubesMIX by SplineGames.com-new addictive puzzle game for Pocket PC.
The aim of the game is to collect the composition of the tubes at the board in the limited time (the sample of the composition can be seen at the top left corner small board).
There are bonus levels, the purpose of them is to place the tubes with water in the correct order (the sample can be see at the small board too).
To move the figure you should click at it with the stylus, to choose the direction – use the arrows or the cursory buttons.
The figure moves till the encounter with the border or another figure!
Stop or turn of the figure while it is moving impossible!
The number of points depends on the time spent on the level, the number of movement and the skill level (Novice, Expert, and Master).
You can undo your last movement with the help of Undo in the Menu.
Game download and trial period are free!
Have a nice game!
Download and use it now: TubesMIX for PocketPC 1.2 free download
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Refresh yourself with a stimulating vocabulary game for brains of all ages.Download
Size: 750 KB
Price: $9.95 to buy
Operating System: Windows System
Publisher/Developer: SplineGames.com
Release Date: May 17, 2012View Program Details
Top Downloadslast week
Program TagsPopular tags for TubesMIX for PocketPC 1.2
- addictive puzzle game
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Harry watched, hand in hand with Pansy, as the Durmstrang boat set sail to return to its home. The calm waters of the Black Lake parting gently as it took off into the setting sun.
Walking backward into the courtyard, Harry smiled and kissed his fiancée. In just a week, they would be married. Harry really could have been more excited at the thought.
Seeing Fleur and Gabrielle Delacour walk out of the courtyard, heading toward the Beauxbatons carriage, Harry quickly alerted Pansy of his intentions. When no word of rejection or refusal came, Harry called after the two young ladies,
"Fleur!" he shouted, running with Pansy toward them, "Gabby!"
Both of them turned around and looked at him. Gabrielle looked rather shy as she looked up at Harry. She turned slightly and blushed.
Harry and Pansy took it in turns to hug the two sisters.
"I was wondering," began Harry, looking at Fleur, "You know that Pansy and I are getting married, and, well... we'd be honored if you would be willing to be bridesmaids for the wedding."
"We 'ardly know each uzzer." Fleur admitted. "But, with Gabrielle attending 'Ogwarts zees next year, I suppose zat will change."
Gabrielle smiled widely.
"You'll be attending Hogwarts?" asked Harry, leaning down slightly to look into the eleven-year-old's eyes.
She gave a small, shy nod. Harry stood once again, and Fleur wrapped Harry in a caring hug,
"Of 'course we weel 'elp you, when eez eet?"
Gabrielle wrapped her own arms around Harry for a hug as well.
"Next Saturday." said Harry simply. Fleur's eyes bulged as she pulled out of the hug, disappointing her little sister slightly.
"So soon?" she breathed, "But, zee dresses?"
"The designs for the bridesmaids dresses have already been chosen." reassured Pansy, laughing softly, "We'll owl you about you sizes."
Harry kissed Fleur's cheek, much to the jealousy and envy of little Gabrielle. Pansy hugged Fleur and waved her off as she climbed into the carriage.
"Thank you."
Luggage in hand, walking beside Pansy and Hermione, followed by Ron, Harry made his way down to Hogsmeade to board the Hogwarts Express.
"Everything is going to change now, isn't it?" whispered Hermione, sighing softly.
"Obviously, yes." Harry laughed, "We're getting married!" he hugged Pansy by the waist and kissed her cheek. Pansy giggled appreciatively.
"I mean... out there." Hermione corrected, staring off into the sky. She looked a little mystified.
Harry thought in silence for a few seconds before responding with a simple,
Hermione breathed and turned her eyes to focus on each Pansy, Harry, and Ron in turn,
"Promise me you'll write this summer, all three of you!"
"Hermione," cackled Pansy, "We won't be gone that long, we'll be seeing you at the wedding next week!" she smiled, "Not to mention probably every day save maybe tomorrow for the preparations!"
Hermione swept both Pansy and Harry into a tight hug,
"I know. But it's just such a long time." she pouted, sounding very much like a small child.
Chuckling heartily, Harry took his first steps onto the train. Next year, he would arrive here a married man. A changed man.
Hogwarts would never be the same. Harry, Pansy, Hermione, even Ron, would never be the same.
They had learned this year, through bonding, friendship, and even a little romance, that sacrificing yourself, whether by giving your life as Krum did, or by enduring one another's burdens as Pansy had, by giving yourself away for the ones you care for, you show through the greatest way possible that you care.
Not one soul could leave Hogwarts this year unchanged. Whether member of Beauxbatons, Durmstrang, or Hogwarts, they would always remember. Always remember that in the end, when all is said and done, the only thing that matters is love.
The End