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Phase II Study of Intravenous Immunoglobulin (IVIg) for Alzheimer's Disease
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|Alzheimer's Disease
|Drug: Intravenous Immunoglobulin
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
|Official Title:
|A Placebo-controlled, Randomized, Double-Blind Phase II Clinical Study of Gammagard Intravenous Immunoglobulin (IVIg) for Treatment of Mild to Moderate Alzheimer's Disease
- ADAS-Cog
- ADCS Pharmacoeconomic Assessment
- Plasma and CSF anti-amyloid antibody titers
- Plasma and CSF beta amyloid levels
- FDG Cerebral Glucose Utilization
- PIB Cerebral Amyloid Distribution (PET)
- PK11195 Microglial Activation (PET)
- Adverse Event Frequency and Severity
|Estimated Enrollment:
|Study Start Date:
|February 2006
|Study Completion Date:
|April 2010
|Primary Completion Date:
|January 2009 (Final data collection date for primary outcome measure)
Abnormal processing of the beta-amyloid protein is thought to be an early and causative event in the pathogenesis of Alzheimer's disease (AD). Immunotherapy targeting beta amyloid (Aβ) has demonstrated a remarkable capacity to arrest and even reverse elements of AD brain pathology. Intravenous Immunoglobulin (IVIg) is a medication obtained from the pooled plasma of healthy human blood donors that contains natural anti-amyloid antibodies and exhibits potent central nervous system anti-inflammatory properties. IVIg has been FDA-approved and used for more than 25 years in patients with a variety of immune deficiency and autoimmune diseases and has an established safety record, but is not FDA-approved for the treatment of AD.
A total of 24 patients, males and females 50 years of age and older, with mild to moderate Alzheimer's disease (AD) will be enrolled in this research study. To be eligible, patients must meet the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria for probable AD. After written informed consent is obtained, subjects will go through a screening process to determine if he or she meets the inclusion criteria. Screening procedures include medical history, blood and urine tests, neurologic exam, chest x-ray and MRI. Women who want to take part in this study must either be post-menopausal, surgically sterilized or agree to avoid becoming pregnant during the entire period of their participation in this study.
To be eligible for this research study, patients must be taking a stable dose of an approved AD medication for at least 3 months prior to entering this study or be unable to take these medications. The design of this protocol is that of an add-on study and we will recommend patients continue to take any FDA-approved AD medications they are taking at study entry.
Subjects' participation in the study will last approximately 19 months, including screening and baseline procedures, treatment with study drug and a follow-up visit 1 ½ months after finishing treatment, plus a visit for blood tests 6 months after the last infusion in the study. This research study requires that the patient have another person, (such as a spouse, child, other relative, close friend, aide or other professional caregiver), who will accompany the patient to each clinic visit.
Subjects will be randomized to a treatment group for 6 months of infusions of IVIg or placebo. The treatment groups compare different doses and frequencies of treatment. Patients will have a 33% chance of receiving placebo.
Blood will be obtained from subjects every two weeks and examined in our research laboratories to obtain more information about IVIg's biological effects. Cerebrospinal fluid will be obtained by lumbar puncture twice over the course of the study for the same purpose. Patients will be asked to allow a portion of a blood sample to be used for Apolipoprotein E (APOE) testing and banked for genetic research testing related to AD and aging, but do not have to participate in the testing or allow their blood sample to be stored in order to take part in the study.
Cognitive testing will be carried out at baseline and every three months over a period of 18 months. Results of cognitive testing will constitute the primary endpoint of this study. Positron Emission Tomography (PET) imaging substudies will be performed at two time points during the study. Safety laboratories and assessments will be carried out at regular intervals. Subjects will not be responsible for any research study-related costs but will be responsible for the costs of evaluations required to establish diagnosis.
|Ages Eligible for Study:
|50 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of probable Alzheimer's disease (AD) of mild to moderate severity (as determined by a Mini Mental State Examination (MMSE) score of 14 - 26 inclusive).
- Ability to give informed consent, designate a decision-maker or have an already recognized decision-maker (such as a legal guardian or health care proxy).
- Ability to comply with testing and infusion regimen.
- An able caregiver willing to participate (such as a spouse, child, other relative, close friend, aide or other professional caregiver closely involved in helping the patient take care of himself/herself).
- Venous access suitable for repeated infusion and phlebotomy.
- On stable doses of approved AD medications for at least 3 months.
- As applicable, on stable doses of psychoactive medications (e.g. antidepressants, antipsychotics) for at least 6 weeks.
- Neuroimaging performed after symptom onset consistent with the patient's diagnosis.
- Clinical laboratory values within normal limits or if abnormal, judged clinically insignificant by the Principal Investigator.
- Women who want to take part in this study must either be post-menopausal, surgically sterilized or agree to avoid becoming pregnant during the entire period of their participation in this study.
Exclusion Criteria:
- Non-Alzheimer dementia.
- Active renal disease.
- Abnormally high serum viscosity levels.
- Immunoglobulin A (IgA) deficiency.
- Untreated congestive heart failure, unstable angina or a history of recent myocardial infarction.
- Unstable arrhythmia.
- Untreated or poorly controlled hypercholesterolemia.
- Untreated or poorly controlled hypertension.
- Poorly controlled diabetes.
- Thrombosis (central or peripheral) in the past year.
- Modified Hachinski score > 5.
- Active cancer diagnosis, except basal cell carcinoma.
- Active autoimmune or neuroimmunologic disorder.
- History of IVIg treatment in past 6 months.
- Untreated major depression or other major psychiatric disorders.
- Known coagulopathy or platelet counts < 100,000.
- Positive serology for Hepatitis B or C, or HIV.
- Active migraines or frequent headaches (3 or more times per week).
- Taking immunosuppressive drugs.
- Chronic (more than thrice weekly) use of non-steroidal anti-inflammatory drugs (NSAIDs), excluding aspirin 81 milligrams daily.
- Received an investigational treatment for AD within 3 months of study entry.
- A history of or current disorder or disease that in a physician co-investigator's judgment may impede the subject's participation in the study, pose immoderate risk to the patient or confound the results of the study
Please refer to this study by its ClinicalTrials.gov identifier: NCT00299988
|United States, New York
|Weill Medical College of Cornell University
|New York City, New York, United States, 10021
|Principal Investigator:
|Norman R Relkin, M.D., Ph.D.
|Weill Medical College of Cornell University
|ClinicalTrials.gov Identifier:
|NCT00299988 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 3, 2006
|Last Updated:
|November 8, 2010
Keywords provided by Weill Medical College of Cornell University:
Amyloid beta protein
Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
Immunoglobulins, Intravenous
Rho(D) Immune Globulin
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


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Rosario understands Rockies' desire to rest him
SAN FRANCISCO -- Rockies catcher Wilin Rosario always believes he has energy, but he appreciated the rest he received Wednesday and Thursday.
Rosario, who didn't handle two blockable balls in Monday night's 5-1 loss to the D-backs but delivered the winning single in the 10th inning of a 5-4 victory Tuesday, was back in the lineup Friday against the Giants.
Balancing strong offense -- .284, nine homers, 27 RBIs in 38 games -- with his developing defense is a continuing story for Rosario, who said he hasn't felt fatigued but figures manager Walt Weiss and the coaches will be proactive about resting him if they see something he doesn't.
"I like to play, but we are human and we get tired," Rosario said. "Maybe we don't feel it now but maybe later in the season we'll start feeling it. So the skipper knows what he's doing. Plus everybody that we have plays very well and they like to play. We aren't afraid to rest guys."
Weiss said, "Catching is tough. Those guys get beat up a lot back there. I try to keep Wilin from catching day games after night games, even though he has done it a couple of times. It's a demanding position. I think he's done real well handling the rigors."
Rosario said he is spending extra time before games doing exercises and receiving massage and heat therapy on leg muscles. Some of his struggles last season, when he had 21 passed balls and 13 errors, were due to a lack of flexibility, the Rockies theorized. A knee surgery that Rosario underwent in the Minors cost him some elasticity in his legs, but that situation is one he and the club hope to improve.
Thomas Harding is a reporter for MLB.com. Read his blog, Hardball in the Rockies, and follow him on Twitter @harding_at_mlb. This story was not subject to the approval of Major League Baseball or its clubs.

subset: commoncrawl


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Komets General Manager David Franke said the compensation has already been agreed upon between the teams.
Most fans are expecting the Komets to lose a player, or at least the rights to an unsigned player after Alaska coach Rob Murray said in a news release, "I am very confident that the futures we receive as part of this deal with go a long way in making us a better team next season.''
Future considerations can mean anything, and sometimes has. Over the years, the Komets have traded cash, hotel accommodations, travel money, bus rentals, food and even future considerations from another trade for players. Sometimes, teams agree to pick from a list of players after they've had a chance to scout their opponents.
"You can basically do whatever you want to,'' Franke said. "It all depends on what you work out with other team.''
Maybe Fort Wayne's most noteworthy ``future considerations'' trade happened in 1993 when the Komets received defenseman Jean-Marc Richard and forward Peter Hankinson from the San Diego Gulls. Two months later, Max Middendorf was sent to the Gulls. The trade helped spark the Komets to their 1993 Turner Cup playoff run.
The oddest "future considerations'' deal came before the 1996-97 season. Forward Andy Bezeau was upset with the Komets and demanded a trade, even going so far as to attend training camp with the Michigan K-Wings. The K-Wings and Komets were trying to work out a trade when things got very strange.
When the Phoenix Roadrunners folded the year before, the K-Wings hired equipment manager Steve Wissman, who brought several truckloads of supplies with him, including the Roadrunners' washers and dryers. A Fort Wayne native and former Komets equipment manager, Wissman knew the Komets' washers and dryers were almost worn out so he called current Fort Wayne equipment manager Joe Franke to ask if he wanted the dryers.
Franke told the Komets front office about the possibility, and talks started with the K-Wings. Eventually, the Komets traded Bezeau's rights to Kalamazoo for "future considerations" which turned out to be two dryers worth about $1,600 apiece.
After Bezeau had played one game in Michigan, the IHL voided the trade - though no one can remember why - so the Komets ended up buying the dryers that they are still using today.
That's not even the strangest trade in Komets history. During the 1960s, Ken Ullyot claimed he once traded a player for a goal net, but that story is likely full of holes.


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This article is a guild information page for Shadows of Argus of Moon Guard US.
The contents herein are entirely player made and in no way represent official World of Warcraft history or occurrences which are accurate for all realms. The characters and events listed are of an independent nature and applied for roleplaying, fictional, speculative, or opinions from a limited playerbase only. Guild pages must comply with the guild page policy.
<Shadows of Argus> is a draenei-centric RP-PvP guild headquartered in Ironforge. <Shadows> is, in part, an intelligence service and covert ops organization operating in support of the Hand of Argus. More than this, though, it is an order of Draenei who are more practical-minded than some of their kin when it comes to doing what they think needs to be done to further the interests of their people. This includes working with character classes and personality types that other Draenei might not choose to associate with. It also means they're willing to use less-tasteful methods of getting the job done, when necessary.
To fill out an application go to http://shadowsofargus.enjin.com For more information you can contact Maeorra, Glyllena, or Arloth in game.
FAQ Edit
1.) "Isn't this a Draenei guild? What about the other races?"
Sort of. We're trying something new. The premise is that these are Draenei who have taken it upon themselves to enlist the aid of members of the other races and include them in their day-to-day operations. We encourage Draenei RPers who might enjoy that prospect to give us a look! Other races who are interested in learning about and making friends with Draenei are also encouraged to join and see what we have to offer.
2.) "Are there class restrictions?"
No! As above, the premise of the guild is inclusive of all allied races and classes. The only characters that won't really have a place in <Shadows> are those (more pious and traditional Draenei, for example) who refuse to associate with "undesirables" like rogues and warlocks, and also characters who are unabashedly and unrepentantly evil. That's not what we're about. You've got to at least have somewhat of a conscience to belong here.
3.) "Draenei hiring mercenaries? Draenei associating openly with rogues and warlocks? Draenei stooping to spying, sabotage, interrogation, and even assassination? Isn't that kinda lore-breaking?"
Not really. The Hand of Argus, in the Bloodmyst quest line, are shown to be very pragmatic individuals who'll do whatever it takes to achieve their goals. While certain members of Draenei society might well regard themselves as being above such behavior and such associations, the Draenei have been trying for quite a long time now to make their place in the world, and some of them might well have come to the conclusion that they can't afford to cling to such haughtiness anymore. Indeed, haughtiness and insularity have cost them dearly in the past.
4.) "Do I have to be a Draenei lore expert, or a very experienced RPer?"
Not at all. But we would like you to at least have an interest. We're more than happy to teach you what you need to know.
5.) "Do I have to PVP?"
Not if you don't want to. It's a big component of what we do, so of course we encourage participation in PVP events and also taking part in running BGs and PvP training events for gear and experience, but if you do not enjoy PVP, don't sweat it. There is no requirement to do so.
IC Ranks Edit
Each branch will be generally suited to specific classes and roles, but there is certainly no rigid guideline as to which class/role can join a specific branch. It mostly comes down to how you want to RP your character and the sort of role you'd like to have within the guild. ALL OF THE BRANCHES MATTER, and all of the branches will take part in RP and events, as appropriate. The idea is not to make some seem more useful or glamorous than others. It's purely for RP flavor and immersion
Emissary OOCly, the Emissary is the Guild Master. ICly, he or she is the same rank as the rest of the officers (Archons). He or she is simply the Archon whose job is to interact with other guilds in a Public Relations kind of way. This is currently Xeula.
Archon OOCly the Archons are the Guild Officers. ICly they are the leaders of the order. They are currently Glyllena, Arloth, and Maeorra.
Archons are the only rank allowed to wear a Renowned Guild Tabard ICly.
Archon Alt OOCly these are the Officers' alts. Their IC rank will be indicated in the character note, which can be found in the in-game Guild roster. All Archon Alts should be treated according to their IC rank in IC situations.
Shield This is the most prestigious rank that a member can attain. ICly the Shields are the members in whom the Archons trust the most. They are relied on to take charge of situations (ICly) when an Archon is not present. The Archons often tell the Shields what they know and sometimes ask them to weigh in on important decisions. The Shields are the most skilled soldiers in the Shadows of Argus. OOCly, they participate in and create RP events regularly and show initiative in participating in and/or driving PvE and PvP initiatives in the guild: either raids, battlegrounds, guild group dungeons runs etc. Top gear for these characters is recommended but not required. Shields must be level capped.
Shields are permitted to wear an Illustrious Guild Tabard ICly.
Valiant These would be our time-tested members. Soldiers, support roles, tradesmen etc. Valiants participate in RP events regularly. They are encouraged to participate in OOC PvE and/or PvP runs from time to time as well, but might not have top gear. Valiants must be level capped.
[Valiants are permitted to wear an Illustrious Guild Tabard ICly.
OOC All OOC or casual Alts as well as purely OOC players would be ranked at this level. OOC ranked members have the same guild bank privileges as those in Peacekeeper rank.
Peacekeeper This rank is our newest recruits. They have been inducted into the order ICly and will remain at this rank until they prove themselves to the order. All characters must reach level 20 before being formally inducted and promoted to this rank.
Peacekeepers are permitted to wear the simple, basic Guild Tabard ICly.
Neophyte People who are interested in joining but have not yet been sworn/initiated in. All prospectives must be at least level 10 before being invited to the guild. Neophytes will remain at this rank for approximately two weeks before being eligible for promotion, however, the Archons (officers) can choose to hold anyone at this rank for a long period of time should they feel the need to.
Neophytes should not wear Guild Tabards at all ICly. A Guild Tabard will be given to them after their formal induction.
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At Intelligent Office of Atlanta, we have a variety of virtual office services that you can customize to fit your business needs and your budget. Our virtual office services are available a la carte, giving you the flexibility to grow your business while avoiding unnecessary overhead. Intelligent Office provides flexible virtual office space solutions, including: fully serviced office space, shared office space, executive suites, and conference room rentals with customizable lease terms across the United States and Canada. Additionally, we provide various services that a growing business can take advantage of as needed. )
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Posted 7 years ago
(1 item)
Found this in an basement collection. Would anyone have any idea who the manufacturer is, what year, what train or what its worth. It is a Two rail brass o-scale engine. I do know that it is supposed to be Japanese. It says C 622 on the cab. Possibly imported by Max Gray in the 50s at some point. Thanks


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Topic: Ascities getting out of control
Is anyone familiar with ascities(sp?) What seemed to be slight swelling in my dads abdomen 2 weeks ago has grown and he looks 9 months pregnant. Every morning I stop into see him, and his belly looks bigger then the day before. I spoke the Hospice Dr. and he said in my dads case he couldn't drain it b/c my dad has pockets of tumors in the abdominal region and it would be impossible to drain. He also said draining usually doesnt work. The fluid comes back mroe rapidly than usual and more. The question is, how much bigger can he get, at this rate it seems eventually it will affect his breating because the swelling is going to push into his diaphram. The swelling is making it impossible for him to even sit, he has to lay in bed all day.
Any info would be oh so helpful
Thank you


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On the Amendment S.Amdt. 423: Fowler S.Amdt.423; To increase appropriations for resource management and land acquisition programs of the Fish and Wildlife Service, for operation of the National Park Service, for national recreation and preservation programs, for the Historic Preservation Fund, for State and private forestry programs, and for general expenses of the Forest Service, and to decrease appropriations for construction programs of the Forest Service.
Result: Agreed to (55-44, 1 member not voting, 1/2 threshold)
Details: [click here]
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By T.W. Budig, ECM Capitol Reporter
National Football League Commissioner (NFL) Roger Goodell left a meeting with Democratic Gov. Mark Dayton and legislative leaders this morning (April 20) at the State Capitol talking about a productive meeting and dismissing the idea his presence served a threat.
"No, there was not," Goodell said of the NFL issuing an ultimatum to legislative leaders on the Vikings' stadium issue.
"No implied threat, or any threats at all," said Goodell in brief comments to the media about the visit.
Instead, Goodell said the presence of Pittsburgh Steelers President Art Rooney II and himself "signaled" how import it was to the league that a stadium resolution be found.
They believed that after many years the time had come to pass stadium legislation "and move forward," he said.
Rooney said he realized how important the Vikings' stadium issue was to the commissioner after suggesting the two delay their visit to Minnesota until after the NFL player draft.
But Goodell indicated the matter was too important to wait, said Rooney.
Goodell expressed hope that there was a "general commitment" among state leaders to address the stadium issue this session.
Legislative leaders disagreed on whether the NFL officials mentioned Los Angeles — one Vikings' scenario is that unless the stadium issue is quickly resolved the team will end up on the West Coast — with Sen. Julie Rosen, R-Fairmont, Senate stadium bill author, indicating the Los Angeles was mentioned.
Indeed, Rosen styled the visit by the NFL officials as a "reality check."
Senate Majority Leader David Senjem, R-Rochester, in his comments outside the Governor's Office indicated he didn't remember the subject of Los Angeles coming up.
Senjem thought the NFL officials were "clear and loud" that their emphasis was on keeping the Minnesota Vikings competitive and in Minnesota.
But Dayton suggested that NFL officials have made plain that the stadium issue cannot go on indefinitely.
"The writing is on the wall," said Dayton.
"They're talking reality," he said.
Both Senjem and House Speaker Kurt Zellers, R-Maple Grove, styled the Vikings' stadium issue as complicated.
"Things will have to be moving a little more quickly," said Zellers.
The House Vikings' stadium bill is "essentially dead" in the House Government Operations and Elections Committee, said Zellers.
But there are ways of reviving legislation, he said.
Rep. Morrie Lanning, R-Moorhead, House Vikings' stadium bill author, noted that it was first time NFL officials and all the legislative leaders and stadium bill authors had met together.
"To me that's very significant," he said.
The Senate is expected to hold a hearing on three Vikings' stadium bills today in the Senate Local Government and Elections Committee.
Senate Minority Leader Tom Bakk, DFL-Cook, indicated Senate Democrats on the committee will vote to move the bill out of the committee where it is now tabled.
But that depends, he said, adding a note of caution, on what ends up in the bill.


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Dr. Latha Menon MD
- Pulmonary Disease Bronx, NY
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Reviews reflect patients' level of satisfaction with the care they received from this provider. Dr. Latha Menon does not yet have any reviews.
Dr. Latha Menon, MD is a Doctor primarily located in Bronx, NY, with other offices in Bronx, NY and Bronx, NY. She has 40 years of experience. Her specialties include Pulmonary Disease. Dr. Menon is affiliated with Bronx Lebanon Hospital Center - Fulton Division, Jacobi Medical Center and Albert Einstein College Of Medicine. She speaks English.
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Specialties & Expertise
Dr. Latha Menon has the following 2 areas of expertise, 1 specialty and 2 board certifications.
Pulmonary Disease
A pulmonologist is a physician who specializes in the diagnosis and treatment of conditions related to the lungs and respiratory tract.
These specialists are similar to critical care specialists in that their patients often require mechanical ventilation to assist their breathing.
Pulmonologists diagnose and treat patients with conditions such as asthma, cystic fibrosis, asbestosis, pulmonary fibrosis, lung cancer, COPD, and emphysema. Exposure and inhalation of certain toxic substances may also warrant the services of a pulmonologist.
Some of the tools and tests pulmonologists use to diagnose a patient are a stethoscope in order to listen for abnormal breathing sounds, chest X-rays, CT scans, blood tests, bronchoscopy, and polysomnography.
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SANTA BARBARA -- For a long minute Tuesday, a 20,000-strong contingent of mourners fell into an eerie silence as they gathered to remember the six university students -- including three from the Bay Area -- killed by a self-professed misanthrope.
The only sounds were distant birds and the camera shutters of a massive media blitz, which could be heard from halfway across the football field at the UC Santa Barbara campus.
But it wasn't long before the group raised a collective voice in solidarity to decry gun violence with a chant of "Not one more."
"I saw my son in a dream last night," stated a letter penned by the parents of Cheng Yuan "James" Hong, a 20-year-old from San Jose who was studying computer engineering at UC Santa Barbara. "I know there has been a great injustice, and policy can be improved. My son said he can't be here to help anymore, but you can."
The letter was read by Richard Martinez, whose son Christopher Ross Michaels-Martinez was among those slain in the Friday night rampage. Since then, Martinez has been a vocal opponent of guns and while he said Tuesday that all families don't feel the same, statements he read from the Hong family as well as one from the parents of Weihan "David" Wang, 20, of Fremont, showed them to be aligning with the cause.
Wang's parents expressed the importance of their sons death not being in vain.
"I am sure this will wake the power within America," read the note. "It's time to stop gun violence, and be free from fear."
Though Wang's family attended the memorial, they did not address the crowd, standing only briefly when Martinez mentioned their name.
The capacity crowd at Harder Stadium filled the 17,000 bleacher seats and an additional 1,800 placed on the grass. Those who arrived too late were content to sit on a patch of lawn for the service, which lasted for more than an hour and featured messages of hope and perseverance from top UC officials and religious leaders. They stressed that the message of the day isn't finding out why 22-year-old Elliot Rodger went on his rampage, but remembering those who were slain, including George Chen, a 19-year-old graduate of Leland High School in San Jose.
"It's important that in our grief, that we not lose sight of the lives we have gathered to remember," said UC President Janet Napolitano. "It's important that we do not let the arithmetic of this atrocity define them."
Memorial speakers talked about a student body that came together to support one another after Rodger fatally stabbed his roommates from San Jose and Wang, who was visiting from Fremont, before going on a shooting rampage in the university enclave of Isla Vista. Rodger then turned the gun on himself after exchanging gunfire with authorities.
In addition to Hong, Chen, Michaels-Martinez and Wang, Rodger killed Katherine Cooper, 22, of Chino Hills; and Veronika Weiss, 19, of Thousand Oaks.
As the victims were remembered in Santa Barbara, the killings continued to reverberate around the Bay Area.
At San Jose's Lynbrook High School where Hong graduated in 2012, Principal John Dwyer on Tuesday led a campuswide moment of silence as grief counselors prepared to offer support to students and teachers. There, student Samar Kahn also addressed the campus over the PA system, remembering Hong as "one of the kindest, most genuine people I have met."
Hong was entangled in a conflict with Rodger as recently as January, according to the Santa Barbara Sheriff's Office. Rodger initiated a citizen's arrest of Hong after accusing him of stealing $22 worth of candles. Hong was booked and released, and on Tuesday, a person claiming to be a relative with access to Hong's Facebook account sought to clarify the episode.
According to the relative, Hong and Rodger were engaged in a petty argument where Rodger apparently took away his roommate's measuring cup out of annoyance over his cooking, and Hong retaliated by grabbing Rodger's candlesticks to force an immediate trade.
"In response, Elliot called the police," the relative wrote. "What kind of person would call the police for such a petty argument? ... However my family philosophy is to avoid conflicts as much as possible, and we also wanted to use this opportunity to teach James there are all kinds of people in the world that we would have to get along with. We encouraged James to pay the fine and not aggravate his roommate further."
Sophomore Victor Espinosa-Rosiles, of Oakland, said Tuesday that he met up with friends Friday night across the hall from Rodger's apartment, which was the site -- they later discovered -- of the first horrific crime scene. "That's what freaked us out, that we could have run into him on our way in and his way out," he said.
Lawmakers, meanwhile, reacted to the shooting by announcing plans Tuesday for a bill to create a "gun violence restraining order" system in which concerned relatives, intimate partners or friends can notify police about someone showing a propensity toward violence, so police can investigate and seek a judge's order to seize that person's firearms and prevent any purchases.
Current law lets that process start only when therapists notify police that a client is at risk of committing a violent act. Family members can call police, but if no crime has been committed and the individual doesn't meet criteria for an involuntary civil commitment to mental health treatment, there isn't anything police can do about that person's firearms.
After the memorial, students expressed hope that things would start settling down.
"We've had a lot of bad things happen this year," said Tyler Buron, a 22-year-old UCSB student, referring to the chaotic riot that happened during a spring break party. "Very few people are giving our town a bad reputation."
Wire services and staff writers Mark Gomez, Robert Salonga, Katy Murphy and Josh Richman contributed to this report.


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Randomized Placebo-Controlled Study of Aerobic Exercise and Resistance Training Plus Megestrol Acetate for HIV-Wasting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
OBJECTIVES: I. Evaluate the effect of aerobic exercise and progressive resistance plus megestrol acetate on lean body mass of patients with human immunodeficiency virus-related weight loss (HIV-wasting).
II. Evaluate whether exercise acutely alters immune function. III. Evaluate whether long-term exercise improves immunocompetence. IV. Evaluate the accuracy of multifrequency bioelectrical impedance spectral analysis in measuring body composition.
V. Assess the impact of these therapies on quality of life. VI. Evaluate the effect of these therapies on the balance of energy intake and energy expenditure.
|Acquired Immunodeficiency Syndrome HIV Wasting Syndrome HIV Infections
|Drug: megestrol Behavioral: Exercise
|Study Type:
|Study Design:
|Allocation: Randomized
Primary Purpose: Treatment
|Estimated Enrollment:
|Study Start Date:
|June 1995
PROTOCOL OUTLINE: Patients are randomly assigned to 1 of 3 therapy groups: megestrol acetate alone, exercise plus megestrol acetate, or exercise plus placebo. Therapy continues for 12 weeks.
A single dose of oral megestrol acetate or placebo is administered each morning.
The exercise program consists of aerobic exercise and resistance training performed 3 times a week under supervision. Hard aerobic exercise is performed for 45 minutes plus a warm-up and cool-down period; the patient chooses to work on 3 of 5 pieces of exercise equipment. Exercise intensity is adjusted to a heart rate corresponding to 65% of maximal oxygen consumption.
Resistance training is done on a universal gym; exercises are designed to work all 6 major muscle groups. Each exercise is performed at 70% of maximal single repetition resistance. Resistance is increased 5% when the patient can perform 15 repetitions without failure.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
--Disease Characteristics--
Human immunodeficiency virus seropositive with acquired immune deficiency syndrome
Documented weight loss 5% to 15% below ideal weight
--Prior/Concurrent Therapy--
No concurrent appetite stimulants
At least 6 weeks since initiation of new antiretroviral therapy
--Patient Characteristics--
Performance status: Karnofsky 70%-100%
Hepatic: No ascites
Renal: No nephrosis
- No acute or untreated infection within 4 weeks prior to entry
- No hospitalization within 2 weeks prior to entry
- No gonadal insufficiency
- No edema
- No pleural effusion
- No uncontrolled diarrhea
- No physical or functional obstruction to food intake
- No physical handicap that would prevent resistance or aerobic exercise
- No cardiac abnormality that would render aerobic exercise a health risk
- No concurrent regular exercise of 3 or more hours a week
- No mental incompetence
Please refer to this study by its ClinicalTrials.gov identifier: NCT00004664
|Study Chair:
|Jamie Hayden Von Roenn
|Northwestern University
|ClinicalTrials.gov Identifier:
|NCT00004664 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 24, 2000
|Last Updated:
|June 23, 2005
Keywords provided by Office of Rare Diseases (ORD):
disease-related problem/condition
human immunodeficiency virus infection
immunologic disorders and infectious disorders
rare disease
viral infection
Additional relevant MeSH terms:
HIV Infections
Immunologic Deficiency Syndromes
Acquired Immunodeficiency Syndrome
Wasting Syndrome
HIV Wasting Syndrome
Pathologic Processes
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immune System Diseases
Slow Virus Diseases
Weight Loss
Body Weight Changes
Body Weight
Signs and Symptoms
Metabolic Diseases
Nutrition Disorders
Megestrol Acetate
Contraceptives, Oral, Synthetic
Contraceptives, Oral
Contraceptive Agents, Female
ClinicalTrials.gov processed this record on September 21, 2017


text:
Here's two great circuit bending videos. Which one makes you happier? The first video is of a bent Yamaha QY10. It's from stylinghead (Jesse) and this one can be your very own for $250. I really like the black panel with paint splatter on it. It's like some sort of sound galaxy thing going on. This is one of the more noisy bends I've seen and I could see putting this on the table at some party around 6:00AM.
"This video shows some of the noisy things it can do. It also gets tight and ticky, warm and weird and everything in between." – stylinghead
Next up we have a Talking Cash Register from Michael Una. This unit seems to be a nice fit if your making minimal or Kraftwerk (Amazon link) style material. I love a speech synthesizers and cash so I'm happy.
"A brief demo of the sonic capabilities of a circuit-bent Talking Cash Register. Looped 4x in Ableton Live, with Broken Drum Machine bangin' away in the background." – Michael Una
Talking cash register from Michael Una on Vimeo.
So which bent box would you take home? For more bending action keep an eye on the always great GetLoFi blog: www.getlofi.com
[poll id="5″]


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Bill Guttentag; Ron Kramer; Victoria Chang
|Format: Hardcopy Black & White
|Also Available In:
|English PDF
|List Price: $7.46
|Source: Stanford Graduate School of Business
|Publication Date: Feb 15, 2006
|Product #: EM1-HCB-ENG
|Discipline: General Management
|Length: 18 p, English Hardcopy Black & White
Every Tuesday evening, after a hectic day at the NBC Universal offices in Universal City, Neal Baer kicked up his feet to watch the latest episode of the award-winning police television series, Law & Order: Special Victims Unit (SVU). SVU was part of the triumvirate Law & Order franchise created by Hollywood legend Dick Wolf. The suite of shows included the original Law & Order, SVU, and Law & Order: Criminal Intent. Baer, an Emmy-nominated writer, was a "showrunner" for SVU--industry slang for the person in charge of every aspect of a television series, from story creation to script writing to direction and post-production--essentially the person who "ran the show." The term, showrunner, arose from the need to distinguish the executive producer from the writers, cast members, and post-production people who were often called "co-executive producers." Being a showrunner was analogous to being a baseball manager: "While the baseball manager reports to a general manager as well as a team owner(s), he is still perceived by the players, the public, and the journalists as the driving force behind the team. He is lauded if the team is successful, and fired if the team is losing. The same is true for the showrunner. Also, like a baseball manager, the showrunner works with other producers, who like the manager's coaching staff--the pitching coach, and the first- and third-base coaches--are professionals and expert at what they do." As a showrunner, Baer was a lot like senior managers at traditional corporations--he and SVU had earned enough respect within the industry to lead to a significant amount of autonomy but not absolute freedom. He needed to keep people below and above him happy. And he needed to be strategic at a high level to make a successful series while juggling tight deadlines and budgetary constraints, among other day-to-day details, on multiple episodes.
To teach students about the entertainment industry and television production, in particular, the role of a "showrunner" on a television show.
Management skills


text:
Topic: Good news today
My appointment today at The Cleveland Clinic went really well. My CAT scan showed no new liver tumors, the tumor they radiated in January is dying off and my CA 19-9 is 28. Thank you for your thoughts, prayers and support. God has blessed us again.


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I got this from another message board. I like both ideas and here they are:
New York trades: Jalen Rose, Malik Rose, Channing Frye and Nate Robinson.
Indiana trades: Jamaal Tinsley, Jermaine O'Neal
Memphis trades: Eddie Jones, Jake Tsakalidis and #24
Indiana trades: Foster, Croshere, Johnson
If the Pacers decide to move JO this NY deal would be sweet. Rose = Big expiering, Frye = Future all star, Nate Robinson looks like he will make a good PG. Malik Rose doesn't have me thrilled but I like his game and his contract isn't that bad. 12 million/2 years left on it.
I would do the second trade. I love the way Foster plays, I love what Croshere gives us, and I couldn't be happier with the way AJ has played well during difficult times, but if we can add a big expiering contract like Eddie Jones and a 1rst round pick (its late first round but we can still get a good player there.) it would have to be done, IMO.
Of course doing these deals would mean that we are starting over from scratch but if that is the way Donnie and Larry want to go, I think that these two trades above would be good moves to make, if they want to rebuild from scratch that is.


text: Submitted by Paul.Burnett on Tue, 2013-12-17 10:17 Conservation Vote Up Down +89 + 2012_05_16_0073.jpg The original culvert was impassable to most fish trying to migrate out of the Weber River in search of spawning habitat in Jacobs Creek. I admit that as a biologist, the way I describe much of the work TU does is much more complex and wonky than it probably needs to be…even to my own little boy. He recently turned five and has been really pushing to join me for a day at work in the field. It finally happened in November, when daycare was closed and I was helping to coordinate a culvert replacement project. He had to come. As a father, of course, I laid out a whole list of rules that I needed him to follow, because we were going to be working around heavy equipment and we were quite a distance from home. Our project was a cooperative one with the Utah Division of Wildlife Resources and Questar Gas. They had been replacing a section of their pipeline and the access road, which crosses over Jacobs Creek, a tiny tributary to the Weber River, was impassable to fish. They were agreeable to replacing the culvert with a passable, baffled culvert. My little boy asked why we were replacing the "pipe" on the creek. I tried my best to distill my description to language and concepts that I thought a five year old would understand. But, being trained in biology, I really struggled to keep words like habitat connectivity, metapopulations and stochastic out of the conversation. I realized that some of the most significant challenges we face, when working on the ground is our inability to tell the story of the fish and why we are taking certain actions. IMG_1291.jpg A Weber River Bonneville cutthroat trout caught below the road culvert in 2011. This fish never made it upstream of the culverts. 2013_11_18_XTI_02625.JPG Moving the new baffled culvert in place. 2013_11_18_0008177.JPG Placing fill around the culvert. Jacobs Creek is really outsized in its importance to the Weber River cutthroat trout. In fact it had been under the radar for years, and nobody knew it even had fish prior to 2011. As it turns out, it is a really important stream to cutthroat trout in the Weber. Although it is small (less than 3 feet in width), a large number of cutthroat trout living in the Weber River migrate into the Jacobs Creek attempting to spawn each spring. This culvert, located only a few hundred feet upstream of the mouth of Jacobs Creek was barely passable to fish. By replacing this impassable culvert, we were able to open access to approximately 3 miles of important spawning habitat for Weber River cutthroat trout. 2013_11_19_0008196.jpg The new Jacobs Creek Culvert in place and passable for trout. Later that day, when we got home, my little boy was explaining to his mom why we were replacing the "pipe" in the creek. And he said it quite simply and profoundly…"Because the fish can't get to their nests." He is right. One of the major challenges that the Bonneville cutthroat trout face in the Weber River is that they can't reach their nests (spawning habitat). In fact this was just one of over 100 barriers to fish passage that exist across the Weber River Basin. This project was an example of the collaborative conservation work we are undertaking on the Weber River, helping the cutthroat trout get to their "nests." The bottom line is that by engaging in these important habitat reconnection projects in the tributaries, we are benefitting the cutthroat trout in the mainstem, which we as anglers enjoy as better and more diverse fishing. 2013_11_19_0008186.jpg Native material was placed inside the culvert to enhance fish passage. Log in or register to post comments


text:
AFC Wimbledon's on-loan centre forward Charlie Wyke described Saturday's defeat to promotion-chasing Rochdale as just one of those days.
In what was a tight affair until Scott Hogan netted a 16-minute hat-trick for the visitors in the second half, the Dons were unfortunate not to take the lead with Wyke having two good chances to break the dead lock.
"It's disappointing, and it's a bad result," the 21-year-old on loan from Middlesbrough said.
"It's just one of them days really: the pitch, a couple of bad decisions didn't go our way, everything went against us, and our attitude wasn't really the best."
Wimbledon's game-plan came unstuck after just 27 minutes as midfielder Sammy Moore was forced off with a head injury, meaning changing back to 4-4-2 which Wyke believes threw the players off.
He said: "We'd been working on 3-5-2 in training the past couple of days and with the injuries we had to change it, so I don't think we could have done a lot better than we did today."
Wyke had a golden chance to put Wimbledon ahead in the second half but he and strike partner Danny Hylton ran into each other after he had rounded the Rochdale keeper Josh Lillis.
It was just the second time they had started together after both joining the club in January, and Wyke believes the miscommunication was down to the pair still learning to play with one another.
Wyke added: "I don't really know what happened. I've beaten the goalie, I just went to tap it in and got tackled by my own player, but it's just a lack of communication. We're still just getting used to each other.
"Nothing quite worked for us today; we've just got to bounce back on Tuesday if the game's on and get three points."


text:
Register for free !
Richard Gilbert
Dec 24, 2012
last update:Oct 3, 2014
"Completing the front end engineering design and obtaining Scheme Approval from the Alberta provincial government in November, 2012, the partners will now commence full-scale development work, aiming at production start-up in the first half of 2016," said Japex president Osamu Watanabe.
"Considering investment timing and technical risks, the partners have decided to adopt a staged development approach. More specifically, the initial stage will result in bitumen production capacity of around 20,000 barrels per day."
The board of directors of Japex made the final investment decision to move forward with the oilsands project on Dec. 14
Japan Canada Oil Sands Ltd. (JACOS), a consolidated subsidiary of Japex and its partner, Nexen Inc., propose to construct and operate an in-situ oilsands steam-assisted gravity drainage (SAGD) project situated on the Hangingstone lease area about 52 kilometres southwest of Fort McMurray. The proposed development is an expansion of JACOS's existing Hangingstone Demonstration project, which currently produces 6,000 to 7,000 barrels per day of bitumen.
However, surface features such as Horse Creek favour the construction of a new facility rather than expanding existing facilities.
The major components of the expansion project include:
a Central Processing Facility (CPF) consisting of seven once-through steam generators, production processing, water treatment and recycling facilities, solid waste handling and disposal. The CPF will be developed as a standalone facility in a single phase about 4 kilometres south of the demonstration project;
associated water supply and liquid disposal facilities, a proposed landfill and other infrastructure;
26 wellpads consisting of a total of 175 well pairs required to supply production to the CPF over the projected 25-year project life;
associated network of pipelines and roadways connecting the wellpads to the CPF;
camps for drilling, construction and operation, construction laydown areas and civil storage areas;
an all-weather-road connecting the CPF to the existing Highway 63 intersection;
infrastructure expansion to the site including a natural gas pipeline, diluent and diluted bitumen pipelines and power transmission.
The scope of the proposed expansion will increase capacity by more than 300 per cent.
The development of the Hangingstone Project will establish the oilsands as one of Japex's core business areas.
Japex also plans to consider the possibility of developing other oilsands leases, including Corner and Chard in the future.
JACOS started production utilizing the SAGD method in 1999.
With the support of the Japanese government and industry has been conducting various demonstration tests for finding methods that work for commercial bitumen production in the Canadian oil sands region.
Dec 24, 2012
last update:Oct 3, 2014
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AFTER numerous postponements, The Worcestershire's men finally completed round four of their winter league.
Playing a better ball stableford format, competition for the two remaining places in the knockout stages was hot with three pairs carding 40 points at the Malvern Wells course.
They were Phil Birch (handicap 6) and Lee Whittall (6), Andy McCabe (5) and Paul Wakely (9) and Mark Read (5) and Stuart Green (13).
However, they were all beaten by the successful pairings of Paul Jones (6) and Peter Basten (15) and Tom Howells (4) and Brian Kendall (12) with scores of 42 and 41 points respectively.
Jones and Basten will meet Trevor Simmons (19) and Mike Salmon (17) with Howells and Kendall facing Alan Boyd (12) and Bruce Duncan (10).
Other finalists are Phil Shurmer (2) and Nick Smith (5), who play Dave Marshall (1) and Josh Marshall (13), and John Duncan (16) and Tim Wright (9), who take on Andy Fleming (13) and Richard Sebok (7).
An enthusiastic group of golfers tackled a mixed bowmaker competition in windy conditions.
With trollies not allowed on the course, organisers Trevor and Brenda Cox thoughtfully reduced the competition to 12 holes.
Playing in groups of four with one men's score and one lady's score to count at each hole, a small but quality field was led home by Steff and Chris Nixon, playing with Joan and Gordon Herbert.
Their winning score of 52 points was just one ahead of April Wilding and Andy Greene playing with Tina and Ian Jukes.
Di and Paul Meakin and Yvonne and Mike Cawley were third on 48, two ahead of Elsie and Ralph Kelsall and Simon and Jos Penrhyn on 46.
Despite the testing conditions, the competitiors seemed to enjoy being out on the golf course again.


text:
NEW YORK ( TheStreet) -- Ratings agency Moody's is poised to make a big call on how the 'fiscal cliff' and presidential elections will impact its rating of the U.S. government's debt and the bonds of corporations with heavy government sales or regulation. In a set of Monday research notes, Moody's outlines how the presidential elections and the prospect of a fiscal cliff standoff may impact a range of debt ratings spanning the U.S. Treasury to the healthcare, defense and oil and gas sectors - but the agency isn't yet ready to take a stand on potential downgrades and upgrades just yet. According to Moody's, the re-election of President Barack Obama gives little certainty over the existential issues that hang over the government's finances, notably a potential 'fiscal cliff' of budget cuts and tax increases scheduled for early 2013 and an increase to the nation's debt limit, which some forecasts indicate may be reached by the Spring. Already, Moody's has played a slow-hand in deciding whether to downgrade the U.S. government's debt ratings, after competitor Standard & Poors cut the U.S. from AAA in the wake of a last minute August 2011 deal to raise the government's debt limit and stave off a default. In September, independent ratings firm Egan Jones cut the U.S. government's debt rating one level to AA-, noting how the Federal Reserve's easing efforts may hit the U.S. dollar and drive up inflation. On Aug. 5, S&P was the first agency to cut the government's debt rating, lowering it to AA+ as a result of what's now known as a 'fiscal cliff' that falls short of what's needed to stabilize the government's medium-term debt issues. Moody's sees the fiscal cliff and the government's debt with a little more optimism. The agency said in September it may downgrade the U.S. debt rating from Aaa - its highest rating -- to Aa1 by 2014 if budget negotiations during the 2013 Congressional legislative session fail to stabilize the federal debt to GDP ratio. Currently, Moody's holds the U.S. government's Aaa rating with a "negative" outlook, signaling that a rating review would likely yield a cut. After the election returns put Obama in the White House for a second term as president, the agency is maintaining its language on the government's debt outlook and emphasizing that it would cut ratings were lawmakers to broker a deal that doesn't provide a credible path to debt reduction. In fact, were lawmakers to broker a fiscal cliff deal that kicks the can down the road on debt reduction without outlining specific budget stabilization plans, Moody's hints at a possible downgrade prior to 2014.
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text:
Michelle Obama arrives in China for official visit
(CNN) — First lady Michelle Obama is in China for an official visit to expand Sino-American relations, but she will refrain from talking about political differences. Mrs. Obama, who flew Wednesday from Washington, D.C., is making a week-long trip to …
First Lady Criticized Over Trip To ChinaWBUR
As Michelle Obama and China's first lady Peng Liyuan prepare to meet …Washington Post
Michelle Obama pushes soft diplomacy on visit to ChinaChicago Tribune
Businessweek -Reuters -New York Times (blog)
all 419 news articles
Source: china – Google News
Sharing information is key – China News in UK. Social Commerce and Social Media Management playing a big part. Suaju Ltd


text:
RockHounds' righty shuts down Missions
Updated 12:22 am, Monday, April 22, 2013
Zach Neal is making the most of his opportunity at Midland.
After signing a free-agent contract with Oakland in March, the right-hander from Flower Mound has shined with a 1.33 ERA. He made additional strides Sunday afternoon and earned his first win.
Pitching his longest outing of the year, Neal scattered five hits through seven innings to carry the RockHounds to a 3-1 victory over the Missions at Wolff Stadium.
"I believe things happen for a reason," said Neal, who spent the past two seasons in the Florida Marlins' farm system before asking for his release during spring training to explore other options. "I have a comfortable feeling here. So far, it's been a blessing."
Neal allowed runners every inning but the seventh. But he persevered thanks to four strikeouts and 13 groundouts, two turning into double plays.
"I felt better as the game went on," Neal said. "I got into my groove. My defense was big for me. They bailed me out of some situations."
Sports Channel
Missions starter Donn Roach (2-2) wasn't as fortunate — he was tagged for a career-high 10 hits.
The trouble started quickly as Chad Oberacker ripped Roach's first pitch of the game for a double to right-center. D'Arby Myers walked. Anthony Aliotti followed with a sharp single to center to bring home Oberacker.
Roach avoided more damage by fanning Jefry Marte before center fielder Rico Noel caught Jake Goebbert's liner and threw Myers out at the plate.
Midland struck for runs in the fourth and fifth on run-scoring singles by Darwin Perez and Goebbert.
The Missions avoided the shutout in the ninth.
Midland reliever Carlos Fisher struck out Justin Miller, but a wild pitch enabled the Missions' batter to reach first. After Tommy Medica walked, closer Kyler Newby took over.
Newby got two quick outs, but the third wild pitch of the inning enabled Miller to score. He came back to strike out A.J Kirby-Jones for his third save of the series.
After losing the four-game series, the Missions hope to rebound against Frisco, which sports the best ERA (2.37) in the Texas League.
"We're not going to change our approach," Missions manager Rich Dauer said. "We have to get tougher at some of our bats. The whole idea is to get better."


text:
Tins was shooting very well before his injury. People are judging his shot based on the playoffs, when he was shooting flat-footed. That's not fair.
My only concern with Jamaal is his durability.
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Tins was shooting very well before his injury. People are judging his shot based on the playoffs, when he was shooting flat-footed. That's not fair.
My only concern with Jamaal is his durability.
This space for rent.
2003-2005 correct
2002 (Nets) - yes hurt
2001 (Sixers) - College
Picky? Yeah. I entered into full "die-hard" mode around 2000 (technically a couple years before, but it picked up steam Isiah's first year), so I have these things burned into my brain.
This space for rent.
My sarcasm detector doesn't work past 9PM.
For that matter, how about John Stockton?Why don't we just get Heywood Workman to unretire and replace Tinsley.
Tins is great. We need better depth at the position. AJ is decent, and I think he's improved with the extended playing time he had this year. Jamaal is impatient and he pushes his return days (from injury), and then, while playing hurt, he re-hurts it, and is out more. If we get some sort of decent depth, to help split up the minutes, we'll be just fine. Tins plays a lot of minutes, and he plays hard, he needs some one to help him out.
Think we can trade Bender and Pollard for GINOBLI!?
It's a new day for Pacers Basketball.
Originally Posted by indystarreg
I will never like his defense. His shooting and "street ball" tendencies are OK. But I could live with all that if he could stay healthy. Even when he is playing he's always banged up. I really question whether his body can sustain the rigors of the NBA.
You want another name, Antonio Daniels
I know he's been injury prone, but I want all the main guys back and see what happens next season. I don't want any trades (even Bender), unless they are no brainers that just can't be turned down.Originally Posted by Unclebuck
I really like Antonio Daniels, but he's a SG in a PG's body, the perfect backup PG though. I'd love to have him backing up Tinsley, but I'm content with AJ as the backup.
"Just look at the flowers ........ BANG"
I don't think that we could get another PG that is of the same quality of Tins without giving up alot of talent.


text: Published with a digital code that may no longer be redeemable from the publisher. Do not purchase with the expectation that the code is still valid. Many years ago, Howard and Maria Stark had a baby. There's something you don't know. Learn the truth about Las Vegas and Area 51 as the two great myths of Nevada collide. Meanwhile, in a distant galaxy, Tony Stark screams! The story that will shake Iron Man to his very core starts here!!! $3.99 cover price.


text:
Last Updated on 4 Sept. 2013, Company: Softerra LLC
Softerra Adaxes is a comprehensive solution for management, administration and monitoring of Active Directory. It enables you to automate and secure user provisioning and de-provisioning in Active Directory environments. With its granularly distributed role-based security, administrative tasks automation, approval-based workflow, and enterprise standards enforcement rules, Softerra Adaxes guarantees high-performance user lifecycle management for your enterprise.


text:
"They called her Water Claire."
When the young girl washed up on their shore, no one knew she had been a Vessel. That she had carried a Product. That it had been carved from her belly. Stolen.
Claire had had a son. She was supposed to forget him, but that was impossible. When he was taken from their community, she knew she had to follow. And so her journey began.
But here in this wind-battered village Claire is welcomed as one of their own. In the security of her new home, she is free and loved. She grows stronger. As tempted as she is by the warmth of more human kindness than she has ever known, she cannot stay. Her son is out there; a young boy by now. Claire will stop at nothing to find her child...even if it means trading her own life.
With Son, the two-time Newbery Medal - winning Lois Lowry has spun another mesmerizing tale in this thrilling and long-awaited conclusion to The Giver.
©2012 Lois Lowry (P)2012 Listening Library
"Claire's story stands on its own, but as the final volume in this iconic quartet, it holistically reunites characters, reprises provocative socio-political themes, and offers a transcending message of tolerance and hope." (Kirkus Reviews, starred review)
Say something about yourself!
"A great "build up" to a "let down"!"
I have mixed thoughts on this one. I would give it 2.5 stars if I could.
I greatly appreciated how this wove the disparate strands of The Giver, Gathering Blue, and The Messenger together in a coherent way. (I particularly love The Giver.) Even so, Son stands on its own and is fully accessible to someone who hasn't read Lowry's previous works.
The first and second parts, "Before" and "Between," are hauntingly good (and very reminiscent of The Giver), painting first a dystopian society without emotion or individualism, and then contrasting that with a small but thriving community of outcasts who have created family by choice.
Unfortunately, the third section, "Beyond," takes the tale out of the realm of science fiction or even parable and transforms it into a cartoonish allegory that steals much of the meaning and thoughtfulness from the rest of the work. Suddenly the worlds and woes we've encountered aren't because of good intentions gone bad and ignorance of what could be, or even the almost-mindless tyranny of the few over the many (with, more or less, the complicity of that many), but pure "evil." The final confrontation between Gabe (Gabriel? an angel?) and the Trademaster (the fallen, exiled angel?), with its suggestion that we're willing to give away those parts of ourselves we should treasure most, has all the subtlety of a heavy brick to the head.
I was pleased that the love of a mother for her son, and of that son for his mother - loves that would have been deemed "selfish" and wrong in the world of "Before" - end up saving not only these two individuals, but also their entire community. I only wish this could've been conveyed without trading Lowry's deft touch for a sledgehammer.
Lowry's gift is raising and wrestling with difficult questions, and the first two sections of Son continue in this tradition beautifully. It's unfortunate that she ends this series with somewhat last-minute and trite answers
"This book is phenomenal!!"
I was blown away by how in depth this book went. it answered so many questions that I've had for years! although it ended ubruptly I couldn't have left it better.
"Loved it"
Enjoyable well written story. Fell in love with the characters from the beginning.
Loved how the four books tied into each other.
Smooth and professional narration.
So satisfying.
I have been enjoying listening to books since the late 90's and reading them the old fashioned way since my parents taught me!
"I don't give out 5 stars often!"
This is the final book in the "Giver" trilogy and I don't know why I just found out about it! There are many themes in it relevant to society today but you don't have to delve deeply or use a study guide to get into this book. Great story of perseverance and love in a dystopian society that does not include vampires and werewolves. Or zombies. There are still supernatural "gifts" but they are only a small part of this story that takes place in three separate, very different communities.
The Handmaiden's Tale, or 1984. Big brother is trying to simplify things and make people feel safer by taking away civil and even human rights. Scary!
Her timing and intonation as she reads, along with the way she alters her voice for each character brings them to life. You hear her voice and you want to comfort Claire or shackle the Trade Master.
This is a tough question because anything I can think of right now sounds corny. Maybe,
"In a dystopian world, love and perseverance conquer ignorance and manipulation to find and define family."
Read "The Giver" and "The Messenger" first so you get the most out of this book. Happy listening:+)
"Not a huge fan..."
I only bought this book because I had read the other three stories in this series. I would only recommend this book to someone who has read the other three, only to finish the series. Quite honestly this book did nothing for me to wrap up the original story of "The Giver" I think that this book was only written to please those people that pressured Lowery to tell us what happened to Jonas and Gabe. I became increasingly agitated with the progress of the story/ the characters: Claire took seven years to finally talk to someone about her being there; six years to gain the strength to climb a mountain; chapters talking about the climbing of the mountain in what was only a days journey, discussing every notch, nook, and cranny. Nonetheless, I really enjoyed Book One as it was detailing Claire's life, bringing us back to the community we first learned about in "The Giver".
Not impressed. Maybe I'm too dim witted but I have no idea the point of the Trade Master. Plus, we took forever with the journey of Claire and the ending was far to quick and easy.
No. Everyone lived happily ever after. Although, I'd love to learn more about the Community we first learned about, certainly does not need to be anything about the three main charters, but more of its beginnings and future.
"Wonderful story"
I thoroughly enjoyed The Giver series. The narrator did a fabulous job. highly recommend if you liked The Giver.
"Mother of Gabe..."
This is the story of the mother of the baby from The Giver...confused? If you have read The Giver you won't be, if you have not you should (and the other two books; Gathering Blue and Messanger) before you read this one. I would assume it can stand alone, but it is all the much richer with the background from the other books. Vivid descriptions, raw emotions and hard choices are at the core of this book. The love of a mother can drive even an emotionally deprived girl from the Giver community to embark on a quest of epic proportions.
"a bit slow-going"
I can't place why this book seemed to be so draggy--I have read all the other three in the series and The Giver was so good, I was hoping for more from this. I think perhaps the author simply chose to write for a 4th grade audience and kept her vocabulary and situations at that level. There was a great deal of over-explanation and repetition that an adult reader would not appreciate, but certainly it would be good for children.
An example would be something like getting introduced to a character and a fact about him, and then in the next chapter, the same fact is repeated in an different way, like within the narrative, "She remembered that he had lost his mother as a child and therefore..." it just really seemed for younger children than her previous books so I was disappointed.
And there is a lot of suspension of disbelief --not because it takes place in an alternate society, but because certain things seem too unlikely even within that society.
The narrator has a sort of odd, cheery tone, particularly in the beginning, and it is clear she is trying to channel the freakishly happy dystopian society, so there is a reason for it, however, it was somewhat annoying to me.
I was also not satisfied with the ending as I think it was resolved very quickly and artifically. I believe Lowry is a good enough writer to be able to have made the ending more complex.
"curious places"
great story map, tying things together in worlds closer than we think. a good listen
"2/3rds great, 1/3rd meh"
How do I write this without spoilers. I guess I'll just say that if you've read the other 3 this is worth reading. I felt that the ending was kind of weak but uplifting too.
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text:
Seager works himself onto All-Star radar
SEATTLE -- The Mariners haven't had a starting position player in the All-Star Game since right fielder Ichiro Suzuki's 10-year run ended in 2010, but fans have a chance to change that if Robinson Cano maintains his current lead at second base.
That bid is now down to online voting only as in-stadium balloting has concluded. But fans have one final week to cast their votes for starting position players in the American and National leagues - either online or on mobile devices.
The next American League voting results will be released Monday and full squads for both the AL and NL teams, including pitchers, will be announced on Sunday, July 6.
Cano was the only Mariners player among the top five at his position in the latest balloting released by Major League Baseball. But a case certainly could be made Kyle Seager to make a late push at third base as he's posted some of the best numbers in baseball in the last few weeks.
Seager has hit .391 with eight runs, six doubles, three home runs and 15 RBIs over his last 12 games heading into Friday's series opener with Cleveland. He's tied for eighth among all AL hitters in RBIs with 54 and leads the Mariners with 12 home runs.
Seager's numbers are very comparable to Josh Donaldson of the A's, who currently leads the third-base voting. Donaldson was hitting .249 with an .805 OPS, 18 home runs and 56 RBIs going into Friday's action.
Seager is hitting .267 with an .824 OPS, with 12 home runs and 54 RBIs. Seager has the most doubles of any AL third baseman at 19, is second in hits to Evan Longoria of the Rays, first in triples with three, tied for second in home runs and RBIs behind Donaldson and is second to Adrian Beltre of the Rangers in batting average and OPS.
Yet Seager isn't among the top five third base vote-getters, which currently are Donaldson, Beltre, Manny Machado of the Orioles, Longoria and Brett Lawrie of the Blue Jays.
Cano obviously has more name familiarity as a five-time All-Star with the Yankees and ranks among the league leaders in batting average at .324. The veteran second baseman held a solid lead over Boston's Dustin Pedroia in the most-recent voting results, but will be looking to finish with a strong push as he shoots for his fifth straight starting spot.
Fans can cast their votes for starters at MLB.com -- online or on a mobile device -- using the 2014 All-Star Game MLB.com Ballot Sponsored by Experian until Thursday, July 3, at 8:59 p.m. PT. The 2014 All-Star Game will be played at Target Field on Tuesday, July 15 on FOX.
Greg Johns is a reporter for MLB.com. Follow him on Twitter @GregJohnsMLB as well as his Mariners Musings blog. This story was not subject to the approval of Major League Baseball or its clubs.


text: Statistical mixup brings chuckles to Herd camp By Doug Smock September 4, 2013 Story Share HUNTINGTON, W.Va. - Duplicate numbers are a necessary evil in college football, and the bane of a statkeeper's existence. In a rapid-fire game setting, errors are inevitable and can lead to comical results.The goof-up in Marshall's opening game against Miami was understandable, but epic. Buried at the bottom of the Thundering Herd defensive category was the notation: No. 11, Devon Smith, one assisted tackle."That was kind of funny when [someone] told me that," said Smith, who has not made a collegiate tackle.That was caught and corrected quickly after the keyboards of deadline-harried newspaper writers fell silent and life slowed down for everyone. The tackle was correctly credited to the other No. 11 on the Herd roster, James Rouse.A similar mixup happened with the No. 1s on the Herd, receiver Tommy Shuler and safety A.J. Leggett. But you could see Leggett catching a pass and Shuler defending one, at least in theory.Smith and Rouse? You're talking Tom and Jerry, David and Goliath, Mutt and Jeff and all those other metaphors. Throw in Speedy Gonzalez and Slowpoke Rodriguez for good measure.Rouse is a senior defensive tackle. At 6-foot-5, 268 pounds, he is considered one of the strongest on the Marshall team. He could bench-press "Moo Moo" Smith, a 5-7, 145-pound senior wide receiver, as many times as he wants before getting bored.That's if Rouse could catch Smith. If Smith spotted Rouse 20 yards in a 40-yard dash, he probably catches him - and Rouse is not slow for his position.One of three Penn State transfers on the Herd, Smith could be the fastest human to don a Marshall uniform since Randy Moss. If you doubt that, you simply haven't seen the man go. Gardner-Webb coach Carroll McCray, who has to figure out how to foil Smith this Saturday, has seen him on video. McCray almost couldn't believe his eyes when watching Smith and some of his speedy teammates."There were some things on film, it kind of looked like it was fast-motion, but I realize it was in normal play," McCray said.For their great differences, Smith and Rouse have several things in common. For starters, both changed their numbers to 11 before preseason camp, Smith from No. 33 and Rouse from No. 92.More important, both took the field in the Herd's 52-14 whipping of Miami (Ohio) after long absences, and made an immediate impact. Rouse played for the first time in 231/2 months after overcoming back problems and a torn Achilles tendon.When Smith transferred from bowl-exiled Penn State last year, he redshirted to heal a foot injury, among other reasons. Both found the experience of their returns to the gridiron extra exhilarating. Rouse's next act in a game comes before Saturday's game against Gardner-Webb, when he witnesses the coin toss as one of the Herd's four captains. Kickoff is at 6:30 p.m. at Joan C. Edwards Stadium."I was really nervous at first, before the game," Rouse said. "I got settled in after a couple of drives and it felt good to be out there."Smith echoed that theme: "Man, it was a blessing to get back out on that field. That's all it is, a blessing to get back out there and show these people what I've got."By all accounts, Rouse's contribution to the Herd's defensive domination of the RedHawks went well beyond his one, er, two tackles, one which resulted in a 1-yard loss. Several times he helped push the Miami line back, opening lanes for linebackers such as Jermaine Holmes to blow through and smother ball carriers.Smith's 70 yards on seven punt returns and 75 yards on three catches were more noticeable, especially his 54-yard TD reception of a Rakeem Cato bomb. Playing outside at the "X" position, Smith zoomed by Miami's best cover corner, Dayonne Nunley.Cato's pass didn't lack for altitude or distance. Accordingly, Smith didn't lack for confidence. "He can throw anything, I'm going to go get it," Smith said, mimicking a Moss mantra.If the Miami game is an indication, Smith and Rouse are going to have big senior seasons, statkeepers are going to have to pay extra attention. The Marshall crew has five more games to get that down; statkeepers in other stadiums have a challenge.One thing to remember: Smith is not eager to make his first college tackle, for it probably means an interception or a fumbled punt is involved.Rouse would make a statistical trade, though."That's what my Dad said, they kept on mixing up the names," he said, then joked: "Hopefully, I got a couple catches."Reach Doug Smock at 304-348-5140, email@example.com or follow him at twitter.com/dougsmock. Story Share Story Share Trending Now 1 Deer in 8 WV counties found dead from EHD 2 'Heroin(e)' spotlights women helping combat Huntington's drug crisis 3 New company planning $73M synthetic fuel plant in Greenbrier County 4 YWCA Charleston's Women of Achievement to be honored in March 5 Area EMS workers return from assisting with Irma recovery Herd's Smith ready inside or out Previous Story As promised, fresh legs on WVU line Next Story


text:
No hurry to pick. I would like to see us go down again. If we don't go down, I will pass. Here is why.
It's a blizzard out there in New York. Just horrendous. If I didn't have to work, I would go home. Given how bedraggled everyone is in the New York-New Jersey-Connecticut region, I know I am not alone in this.
Now, in this environment, we have two motivated sellers. We have the people who bought stocks betting that Romney was going to win. Remember, that was the prevailing view 24 hours ago, when we heard and read endless commentators saying that he had huge momentum. You heard the litany: "He is going to take Pennsylvania, Ohio, Florida, Wisconsin even."
Believe me, I followed every comment and every utterance of these people because I know that many of them were offended by my call that Obama would win big and that he would take every battleground state, which he did.
These people tried like heck to embarrass me and attack my character. They acted as if they knew my whole voting record. They didn't know jack. I even invoked Karen Cramer rules, meaning I made it clear that only she knows how I voted for the last 20 years and no one else.
So, that cohort, the totally wrong about Romney's chances cohort, has to blow out of stocks either because they are so disgusted that their guy didn't win or because the stocks they bought will get hurt by a second term from Obama.
The other group? These are the people who want this market to come down. They are prevalent on a day like today and they can play havoc with a thin market.
We are picking for the trust. Where it helps our basis. Nothing aggressive. Small. That's the operative word. Small. And certainly not any more at this level. That's been done!


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Young Bucs sweep up Minors' weekly honors
DETROIT -- Players in the Pirates organization dominated Minor League play last week, collecting a trio of Player of the Week awards.
Matt Hague, who saw extensive action with the '12 Bucs, led off the haul as Player of the Week in the Triple-A International League after collecting seven extra-base blows among his eight hits for the week.
Stetson Allie, the former pitching prospect who transitioned to the other side of the ball less than a year ago, keeps racking up offensive awards. West Virginia's DH/first baseman was named the Double-A South Atlantic League's Player of the Week for after batting .517 with 15 RBIs.
It's the second POW award of the season for Allie, a No. 2 pick as a pitcher in the 2010 First-Year Player Draft who resurfaced as a position player last June. For the season he is hitting .340 with 13 homers and 47 RBIs in 49 games.
Finally, shortstop Alen Hanson picked up the Class A Florida State League Player of the Week award after going 9-for-21.
Tom Singer is a reporter for MLB.com and writes an MLBlog Change for a Nickel. He can also be found on Twitter @Tom_Singer. This story was not subject to the approval of Major League Baseball or its clubs.


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|Nutritive Value of Foods, Home and Garden Bulletin No. 72 (HG-72)
Published in 2002, HG-72 contains data on over 1,274 foods expressed in terms of common household units. The 19 nutrients in the table are water; calories; protein; total fat; saturated, monounsaturated, and polyunsaturated fatty acids; cholesterol; total dietary fiber; calcium; iron; potassium; sodium; vitamin A in IU and RE units; thiamin; riboflavin; niacin; and ascorbic acid. This edition was developed using data from Release 13 of the USDA National Nutrient Database for Standard Reference. HG-72 in PDF.
You will need the Adobe Acrobat viewer to view this publication. This publication can also be downloaded to your PC and/or printed on your printer.


text:
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Forté Team Carbon Road ForkYou can't beat a lightweight carbon fork for vibration damping and responsive handling. With a threadless 1 1/8" aluminum steerer tube, aluminum crown and aluminum dropouts, the Forté Team Carbon Road Fork is the perfect lightweight upgrade for road bikes with aluminum or steel forks.
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Forté Team Carbon Road Fork
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text: Was blowing the food budget worth it? By John Brown April 27, 2008 Story Share One of the advantages of advancing age is that you can sometimes live long enough to see youthful acts of irresponsibility redeemed (though probably never forgiven).Let me explain.In 1983, when I was just beginning my lifelong affair with wine and when I had little or no disposable income, I made a profligate, yet fateful, buying decision.I was on my way to buy the weekly groceries when I stopped to check out the wine selection at the state liquor store, the only place you could purchase wine back then.As I browsed the aisles searching for any wine not bottled in big green jugs, I came across three bottles of 1978 Château Fortia. At that time, Fortia was considered the best producer of Châteauneuf-du-Pape, and the '78 had gotten great reviews.The wine cost $18 a bottle, a stratospheric price to pay for wine back then. I agonized over the decision for all of five minutes before using our weekly grocery money to buy the wine.When my wife asked why I had not gotten all the items on her grocery list, I sheepishly presented her with the three bottles of wine and, as I recall, some peanut butter, bread and lunch meat. To put it mildly, she was not happy, and I heard the words "selfish" and "irresponsible" used repeatedly to describe me over the next several months.In defense of my decision, though, it helps to know a little about the wine I chose over my children's need for nutritional sustenance. Château Fortia is a storied property and its late owner, Baron Le Roy de Boiseaumarie, not only produced among the best Châteauneuf-du-Pape, he developed a system of governmental regulations to insure the quality for everything associated with making wine. This system was the foundation for the Appellation Contrôlée system for all France.I had read about the exploits of Baron Le Roy and the legendary wines he was making so when I saw the opportunity to acquire a few bottles of this monumental wine ... well, you know the rest.Anyway, this past Valentine's Day, my wife asked me to go to our cellar and surprise her with a nice bottle of wine to accompany a special meal she had prepared. (Incidentally, despite even more egregious acts by yours truly over that quarter-century, I am still married to the same long-suffering wife.) You can probably guess what I selected. I did, indeed, surprise her with 1978 Château Fortia.But the biggest surprise was the wine itself!As I decanted it, the wine's orange-brown color did not bode well. There was about an inch of sediment in the bottom of the bottle (which I expected), and when I put my nose to the carafe, there was very little aroma. At least it did not have any off odors, I thought to myself.I set the wine aside for about an hour while dinner was being completed and then, as we sat down to eat, I poured it into our glasses. It had been transformed. As I sniffed and then sipped, the wine had morphed into an aromatic, complex and delicious elixir. Aromas of mint and leather were followed by layered flavors of cherries, caramel and white pepper. What a spectacular wine and one that, surprisingly, held up well to the fillet of beef it accompanied.After we leisurely consumed the bottle, I went online to Robert Parker's Web site (eRobert parker.com). This is what that esteemed critic had to say about the wine (he rated it 95 out of 100) when he last reviewed it in 2000:"This has always been my reference point for Château Fortia (until I tasted the 1970). It remains a prodigious, full-bodied, spectacular Châteauneuf-du-Pape possessing a deep ruby/purple color with only a hint of amber at the edge. A stunning nose of blackberries, pepper, smoke, dried herbs and licorice is followed by a full-bodied wine with a seamless personality, a multilayered texture, and a fabulous wealth of fruit. While fully mature, it is capable of five to seven additional years of life."Well, here it is eight years later and still holding, though for how much longer I cannot predict.So, did my wife forgive me for that act of profligacy 25 years ago? She's not willing to go that far, but I may be able to get closer to redemption since I have two more bottles of the 1978 Château Fortia lying in repose in the cellar.For more on whites and other wines, see the WineBoy blog at thegazz.com. Story Share Story Share Trending Now 1 Police seek car driven by woman found dead in Kanawha River 2 Teen pleads guilty to involuntary manslaughter in Oakes Field shooting 3 Facebook founder visits Cabin Creek Health Systems 4 Man allegedly cuts father in Rand over argument about sandwich 5 $115M project for WV Toyota plant to start in 2020 Readers map out childhood memories Previous Story Hate watering? Here are some less thirsty annuals Next Story