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MANY OF US were drawn to Marin because of the small towns and quality of life. Some of us were poor (I made $44 a week in 1959, when we first moved here) but chose to scrimp by to be able to live here in Marvelous Marin.
We rented and eventually bought homes. (Ronita and I still live in the starter home we purchased in 1963).
It was a constant battle: Save Our Seashore, Save French Ranch, Save the Bay. We battled developers, governmental agencies, Marincello, the Corps of Engineers that wanted to concrete over the creeks in the name of flood control all the way through Fairfax, Caltrans' plan to build the freeway through Fairfax to West Marin to handle all the new development out there and the folks who wanted us to buy into Sonoma County's Warm Springs Dam so we would have the water to build out Marin.
We fought high-density development.
Our slogans were: "Do you know the way to San Jose" and "Don't Los Angelize Marin."
I'll see if I can find some of the old bumper stickers.
In 1972, a new Countywide Plan, entitled "Can the Last Place Last," was adopted.
Was that just a different time? I think not.
Folks are just as passionate today about protecting their quality of life as they were 50 years ago.
The proposed high-density housing for the San Quentin State Prison site, should the prison close, would add an additional 2,000 living units out there. One aspect of the state's Planned Development Area designation is to circumvent the strict enforcement of the California Environmental Quality Act. There is a major push by development and oil interests in Sacramento to roll back CEQA requirements.They call it streamlining.
Now, PDAs are being pushed, but do we have the water or sewer infrastructure and capacity to meet the demands they create?
How about the $180 million needed to increase capacity in just the Ross Valley's sewer system? Can the Central Marin Sanitation Agency handle the additional treatment capacity? Will that desalination plant on the bay have to be built?
No one from Plan Bay Area, the Association of Bay Area Governments or the Metropolitan Transportation Commission has ever contacted the water or sewer agencies regarding their capabilities to provide the potable water necessary or the infrastructure and capacity to transport and treat the new sewerage generated by thousands of living units and thousands of new jobs for all the businesses that will set up shop here.
It takes a half hour to get to Highway 101 from Fairfax during commute times and on weekends the traffic is bumper-to-bumper through Fairfax.
Nothing in Plan Bay Area limits the size of living units, nothing limits monster homes, nothing stops sprawl, nothing protects existing affordable housing, nothing prevents existing apartments from condo conversions, nothing lowers West Marin density from 1 unit to 60 acres to 1 unit to 200 acres and nothing addresses living wage laws for workers in Marin.
The end result of ABAG and MTC's Plan Bay Area is the equivalent of a new city the size of Fairfax and San Anselmo combined — a city of 20,000. Yet, Plan Bay Area does not address cumulative impacts, water supply, schools, sewer infrastructure, roadway capacity and on and on.
I attended my first Plan Bay Area meeting on May 6. Marin does not need this kind of divisive atmosphere. It is time to send Plan Bay Area back to the drawing boards.
Former Fairfax Mayor Frank Egger is the president of the Ross Valley Sanitary District.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Tuesday, September 26, 2017
Head and Neck Cancer
Percentage rate of survival
A very close friend of mine was recently diagnosed with cancer of the epiglottis, cancer of the voice box and cancer of the hyper-pharynx. Normally, can chemo-therapy and radiation lessen the severity of the cancer and if so, to what degree? Would you be able to tell me the percentage rate of survival for these cancerous conditions?
Without knowing the exact staging of your friends disease it is hard to give a definitive response. However, assuming that the disease is limited to the primary site, a patient would receive chemotherapy, radiation and surgical options with the intent of reaching a cure. Your friends oncologist would have all the exact information on his/her staging and would be able to give more information on the individual case. Good luck to your friend.
Heather Hines, RN
Medical Oncology Nurse
School of Medicine
Case Western Reserve University
Panayiotis Savvides, MD
Assistant Professor of Medicine
School of Medicine
Case Western Reserve University

subset: commoncrawl


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January 9, 2012 Approval Letter-CINRYZE
Our STN: BL 125267/312
ViroPharma Biologics, Inc.
Attention: Ms. Pansy J. Minnick
ViroPharma Incorporated
730 Stockton Drive
Exton, PA 19341
Dear Ms. Minnick:
We have approved your request to supplement your biologics license application for C1 Esterase Inhibitor (Human) to include the incorporation of additional safety data from the open-label uncontrolled routine prophylaxis trial protocol LEVP2006-4 ("Change 3" study) into the labeling.
The review of this product was associated with the following National Clinical Trial (NCT) numbers: NCT00462709; NCT01005888; NCT00432510; NCT00438815; and NCT00289211.
Please provide your final content of labeling in Structured Product Labeling (SPL) format and include the carton and container labels. In addition, please submit three original paper copies for carton and container final printed labeling. All final labeling should be submitted as Product Correspondence to this BLA at the time of use (prior to marketing) and include implementation information on FDA Form 356h.
In addition, please submit the final content of labeling (21 CFR 601.14) in SPL format via the FDA automated drug registration and listing system, (eLIST), as described at http://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/default.htm. Information on submitting SPL files using eLIST may be found in the guidance for industry titled, "SPL Standard for Content of Labeling Technical Qs and As at http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM072392.pdf.
You may submit two draft copies of the proposed introductory advertising and promotional labeling with an FDA Form 2253 to the Center for Biologics Evaluation and Research, Advertising and Promotional Labeling Branch, HFM-602, 1401 Rockville Pike, Rockville, MD 20852-1448. You must submit copies of your final advertisement and promotional labeling at the time of initial dissemination or publication, accompanied by Form FDA 2253 (21 CFR 601.12(f)(4)).
All promotional claims must be consistent with and not contrary to approved labeling. You should not make a comparative promotional claim or claim of superiority over other products unless you have substantial evidence or substantial clinical experience to support such claims (21 CFR 202.1(e)(6)).
Please submit an amendment to all pending supplemental applications for this BLA that include revised labeling incorporating a revised content of labeling that includes this change.
Under the Pediatric Research Equity Act (PREA) (21 U.S.C. 355c), all applications for new active ingredients, new indications, new dosage forms, new dosing regimens, or new routes of administration are required to contain an assessment of the safety and effectiveness of the product for the claimed indication in pediatric patients unless this requirement is waived, deferred, or inapplicable.
Because the biological product for this indication has an orphan drug designation, you are exempt from this requirement.
We will include information contained in the above-referenced supplement in your biologics license application file.
Sincerely yours,
Basil Golding, M.D.
Division of Hematology
Office of Blood Research and Review
Center for Biologics
Evaluation and Research


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We're pleased to announce that id Software's FPS classic, DOOM, has returned to the Xbox LIVE Marketplace worldwide. This even includes Germany, where the the game was de-listed from a banned list last year.
Face off against Hell's army as you experience the revolution of DOOM. Lay waste to hordes of demonic monsters with an arsenal of classic weapons including the infamous BFG 9000. Take the deathmatch online via LIVE and battle your friends for dominance of the leaderboards, or team-up with a friend in co-op.
DOOM is available now for 400 Microsoft Points.


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Costa Pacifica
3 out of 5 stars
Read the best port reviews and tips for this cruise itinerary.
|Day 1
|Pointe-A-Pitre, Guadeloupe
|Day 2
|Philipsburg, St. Maarten
|Day 3
|La Romana, Dominican Republic
|Day 4
|Catalina Island
|Day 4
|La Romana, Dominican Republic
|Day 5
|Basseterre, St. Kitts
|Day 6
|St. John's, Antigua
|Day 7
|Fort-De-France, Martinique
|Day 8
|Pointe-A-Pitre, Guadeloupe
A roll call is a space for members who are signed up for the same cruise (same ship & departure date) to connect.
Make friends BEFORE you sail, exchange tips on what to do onboard and in the ports and maybe even organize a shore excursion with your ship mates.


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From Our Editors
Daring spectacle is afoot as John Lawson's Circus assembles under a big-top tent for a performance full of improbable feats. The show crams in performers from around the world, with acts tackling the likes of aerial hoops, handstand contortion and foot-juggling. Further skills on display include dagger-balancing, knife-throwing, and the comedy stylings of Clown Nimmo. Spectators can pick unreserved seats in the marquee, and seek refreshments at on-site stalls. This years show features our fantastic clown Bippo as seen on The Sooty Show. Quick Change Magic. Duo Trapeze, Chinese Pole, Aerial Daring on The Cloudswing, Danger with The Marshals, Hulahoops, Magic, Aerial Net, Handstand Balance and much, much more.


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Albion fans have been warned they could be evicted – and possibly banned – from the American Express Community Stadium if they resist demands to sit down during games.
Bosses at Brighton and Hove Albion claim there has been an increase in the number of supporters persistently standing during matches this season.
To avoid creating "unnecessary tension" and ensure the club meets Football Association rules, stewards have been told to ask fans to sit at quieter spells of games.
However, at the recent match between the Seagulls and Bristol City, three fans were evicted from the stadium after verbally and physically assaulting officials following the requests.
Paul Barber, the club's chief executive, said any supporter who abused its officials can expect a ban from The Amex "likely to be measured in a number of years rather than matches".
This, he added, was in addition to potential police action.
Standing issue
A letter about the issue of persistent standing was handed out to fans as they left the North Stand after Saturday's match with Nottingham Forest at The Amex.
Mr Barber said: "As a club playing in one of the top two divisions of English football we are required to operate and compete in an all-seater stadium.
"Furthermore our ground regulations require us to ensure spectators do not persistently stand in seated areas while play is in progress.
"Clubs who do not comply with the regulations can face having their ground capacity reduced or receive a severe financial penalty – or both."
Mr Barber recognised that the back four rows of the North Stand "would be treated differently" to the rest of the stadium, as was agreed when the ground opened last summer.
Safety certificate
He said this meant requests to sit down would be less frequent.
Mr Barber also warned the club's safety certificate could also be withdrawn if it failed to act.
In summary, he said: "We want a great atmosphere at The Amex and we want everyone to enjoy watching the match.
"However, it is important for everyone to please always remember and respect that we have a moral and legal responsibility to comply with our ground regulations."
It comes in the week there was a debate in Parliament about reintroducing safe standing at football grounds in the UK after the Hillsborough disaster in 1989.
North Stand
Simon Oakley, of Seagulls Over Burwash supporters' club, said: "It's a North Stand problem and when they fill the corners in at the ground it could potentially get worse.
"To be honest when the club told people they could stand for longer periods of the match in the North Stand at the start of last season that sort of opened the flood gates.
"I'm all for safe standing to be honest. It would be great if we could bring it back."
The Argus asked the club if the same laws would be enforced for away supporters but did not receive a response at the time of going to press.
However, some clubs whose fans persistently stand, such as Manchester United, Cardiff City and Leeds United, have had their ticket allocations to away grounds reduced.
See the latest news headlines from The Argus:
- Early morning fire destroys coaches
- Teenage boy in hospital after 15ft fall on to rocks
- Knuckle duster man walks free
- New bosses at pub once owned by celebrity chef
- Armed police respond to sighting of a person with a weapon in a house


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Dubai, Unveils Underwater Hotel With Rooms 33 Feet Below Sea Level
I think this is just so cool! It would be worth the cost to fly to Dubai to experience this! Who wants to vacation with me here?
Dubai, has unveiled plans for a an underwater hotel. Dubai already has the tallest building in the world, they also have dozens of man made islands off their coastline.


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The Alumni Association has no membership fee. In fact, you will receive many of the benefits of the Alumni Association by virtue of being a Ball State University alumnus or alumna. An alumnus is defined as receiving any degree from Ball State University or its predecessors, or by requesting alumni status after completing at least one term at Ball State University. However, active membership in the Alumni Association provides you with the most direct means to develop and maintain a lasting relationship with your alma mater. Active membership is maintained by making an annual contribution to Ball State University through the Ball State University Foundation.
Each active member of the Alumni Association is entitled to an alumni photo ID card that grants many usage privileges at University Libraries. Additionally, active members may obtain a Ball State recreational facilities pass that provides access to the Ball State exercise room, weight room, indoor pool, racquetball courts, and locker and shower facilities. The Cardinal Alumni Retail Discount program—or CARD—also allows anyone carrying an alumni photo ID card to participate in great offers provided by various merchant locations in Muncie and surrounding areas. Save money and show your Cardinal pride by using your Ball State alumni photo ID card! Active members also receive the Alumnus magazine and News from the Cardinal's Nest, an e-newsletter sent monthly. Additional services include medical and life insurance and an affinity credit card.
If reaching out to fellow Ball State graduates is important to you, you may be more interested in services available to affinity groups such as sororities and fraternities or other Ball State organizations. Or, you may be interested in attending a reunion or other alumni event.
For more information about a program that interests you, click on a link or links to the right. If you cannot find what you are looking for here, please contact the Alumni Association and one of our staff members will be glad to help you!


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Brad Keselowski took the lead in the Chase for the Sprint Cup with one race remaining as Jimmie Johnson's hopes for a sixth championship took a huge hit Sunday in a wild, crash- and fight-marred race at Phoenix International Raceway.
Keselowski finished sixth while Johnson wound up 32nd after blowing a tire and crashing with 76 laps remaining at Phoenix International Raceway.
Keselowski finished the race despite being involved in a wild wreck on the final lap that damaged his car.
— Bowyer-Gordon brawl | Race results | Johnson crash alters Chase |
Keselowski holds a 20-point lead over Johnson going into the season finale next week at Homestead-Miami Speedway and can win the championship by finishing 15th or better — 16th or better if he leads a lap and 17th or better if he leads the most laps.
Kevin Harvick won the race two days after news broke that he will leave his Richard Childress Racing team for Stewart-Haas Racing following the 2013 season. Harvick held off Kyle Busch on a green-white-checkered restart and survived the last-lap melee to take the checkered flag ahead of Denny Hamlin, Busch, Kasey Kahne, Ryan Newman and Keselowski.
The race featured another major development as Jeff Gordon and Clint Bowyer tangled on the track, leading to a brawl between their teams on pit road.
Bowyer and Gordon collided while racing for position with seven laps remaining, cutting Gordon's tire and causing him to hit the wall. Gordon then retaliated against Bowyer, spinning him into the wall and causing a three-car crash right in front of Keselowski.
When Gordon climbed from his car, Bowyer's crew rushed him on pit road and threw him to the ground, igniting a brawl between the two teams. After NASCAR officials broke up the melee, Bowyer climbed from his car and ran through the garage after Gordon. He was stopped by a NASCAR official as he got to Gordon's hauler.
Gordon and Bowyer met with NASCAR officials after the race while security guards stood watch outside the NASCAR hauler.
The field was headed to the checkered flag after a green-white-checkered restart when Jeff Burton clipped Danica Patrick causing her to spin. NASCAR did not throw a caution flag and Patrick's car was sitting on the front stretch when the leaders came back around on the final lap. With Patrick's car stalled and oil on the track, several drivers wrecked and Keselowski's car got hit.
He drove away, however, to finish sixth and take the championship lead.
Johnson said he blew a right front tire, causing him to crash and knocking him out of the race.
"We were cruising along and I had a slight vibration," he said. "We were coming into Turn 4 and it went down, and I went straight into the wall."
Keselowski said he was nervous and raced conservatively after hearing that Johnson had crashed.
"I heard he blew a right front and thought, 'What are the conspiracy theorists going to do with this?' " he said. "I realized the same thing can happen to me and I tried not to let that get into me too much and just focus on what I've got to do."
Though he has a somewhat comfortable lead, Keselowski said he is taking nothing for granted going to Homestead.
"Obviously, there are no guarantees," he said. "We could go to Homestead next week and have the same problem and Jimmie takes the points lead back over. There are no guarantees, but I'm very proud to have the points lead heading into next week."
Johnson, meanwhile, was dejected at seeing his championship hopes diminished.
"It's way, way out of our control at this point with the problem we had today," he said. "We just have to go to Homestead and realize that anything can happen down there. It's not the position we wanted to be in leaving Phoenix. I feel terrible for my team and how hard the guys work."
Johnson also sounded as if he knows his hopes for a sixth championship in seven years might be over.
"That's the way it goes," he said. "I hate to see it end that way, but that's racing. We've won a few championships and lost a lot. We'll be back next weekend and next year hungrier than ever."
Keselowski, for one, was not happy with the wild nature of the race and NASCAR not throwing a caution flag when Patrick spun with one lap to go.
"It was borderline ridiculous at times," he said. "We survived and I'm proud of my team. I feel lucky to make it through all the carnage today."
Harvick, who ran down Busch to take the lead before the Gordon-Bowyer crash, was worried about running out of gas on the final restart. He believed that he had taken the white flag before the last caution flag, which would have made him the winner without restarting the race.
Replays showed the race had gone yellow before he crossed the finish line.
The big crash on the final lap occurred behind him as he was taking the checkered flag.
"They were real quick to throw the (first) caution and then they let us run through oil," Harvick said. "I guess it is hard for them to get it right."
Gordon and Bowyer were called to the NASCAR hauler after the race and met with NASCAR officials while security guards waited outside.
After exiting the hauler, Gordon said he retaliated against Bowyer because he had it coming.
"It had escalated over the year and I had just had it," Gordon said. "He had run into me and wrecked me. ... He got into on the back straightaway and pretty much ruined our day and I had had it."
Busch and Hamlin dominated the first half of the race while Keselowski and Johnson worked their way through the field after starting back in the pack.
Keselowski ran ahead of Johnson most of the race and entered the top five after a green-flag pit stop on lap 133.
He continued to work his way forward and had just taken the lead from Busch when Johnson crashed. Johnson was running seventh when he hit the wall.
With Keselowski leading the race, Johnson took his car to the garage, where his team immediately began replacing the right front. Johnson fell to 32nd after the crash and was 38 laps behind when he returned to the race with 36 laps remaining.
Keselowski was running third when he elected to pit under caution with 40 laps remaining. While the top eight drivers stayed on the track, Keselowski changed just two tires and restarted in 10th. He had worked his way back to sixth when the Gordon-Bowyer incident broke out.
Harvick, meanwhile, had worked his way into contention and passed Busch for the lead on a restart with eight laps remaining. He then held off Busch on the final restart for his first win of the season.
The win came just two days after new broke that Harvick may be leaving RCR after next season.


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just need a simple lil enclosed drive w/ an ethernet jack on it.
i know i can get like 17TB for $180, but i only need 100gb or so and wanting to spend as little as possible on this.
if you have something that fits this bill let me know how much you want for it.


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* Prices may differ from that shown
I do like using cleansing milk as I prefer the thin consistency and find that they usually do just a good a job as the more thicker concentrated products which I find sometimes leave a residue on my face. I find a good cleansing milk will remove all traces of make up from my face and leave it feeling refreshed and product free. I have bought quite a lot of Clinique products over the years and have always found them to be suitable for my skin and to last a long time. This Take The Day Off cleansing milk costs £17.99 and it comes in a purple bottle with a pump dispenser.
This cleansing milk has been dermatologically tested and I can say that it has never irritated my skin or caused any irritation. The liquid is white and milky in appearance and it smells fresh and clean without being too strong or overpowering. It is hypo-allergenic and does not contain any alcohol and it is supposed to give your skin a radiance as well as cleansing.
To use I will pump a small amount onto a cotton wool pad and find that you don't really need much as it seems to go a long way. It stays on the cotton wool pad without soaking right in and I find that one application is enough to wipe over my whole face and neck. I will use small outward sweeping motions starting at the top of my face going down to my neck and then will finish off by wiping around my eyes.
My skin feels soft and quite hydrated afterwards and I don't feel the need to use anything else straight away although I will use a moisturiser or night cream just before going to bed. I think that my skin does look smooth and bright with using this milk and the fresh clean feeling does last for some time.
I do like this cleanser and will continue to use it and would buy it again. It is a good quality product which is gentle but removes every trace of my make up and leaves my skin feeling clean and fresh.
I have been a huge fan of Clinique skin care for years and at one point used there 3 step regime religiously until my skin stopped absorbing the dramatically different moisturiser and it started to just rub into clumps and then peel off. So I tried the gel version with the same results. Then the anti blemish solution 3 step system made my already bad acne about 10 times worse after a couple of months use it also left my skin extremely dry and uncomfortable. ANYWAY... Not wanting to give up on my favorite brand and after reading tons of glowing reviews I thought I would try the Take off the Day cleansing milk at first I thought it was great the solution is not to heavy and removes EVERY last trace of make up incredibly quickly for a cleansing milk the one thing I didn't like about it then was the over chemically smell so unusual from Clinique I know there 100% fragrance free but the chemical smell is slightly over powering.
I used it almost daily for around 6 months without any problems then out of the blue after using it one night my skin started to feel tight and itchy. I thought it must have been the time of the year as it was winter I work in an air conditioned office so slapped a load of moisturiser on and ignored it.
Used it again the next day and the same thing happened and this time it started to sting quite a bit so I washed it off with a warm water, normally I would wipe it off with damp cotton wool pads.
The next morning my skin was red raw, itchy and really really quite sore. I lightly doused it was some water and slapped some gentle moisturiser on and didn't wear any make up. The redness and soreness progressively got worse over the course of about 4 days then a thin dry layer of skin started to appear covering my whole face which was incredibly tight and uncomfortable I literally couldn't smile it would pull so much and hurt, everything I put on my skin stung like hell! including the E45 cream my GP told me to use. Then after about a week it started to flake off and became so itchy I struggled to sleep and the E45 was still stinging like mad! It took around 3 weeks since the dry skin appeared to heal completely.
I wasn't convinced at first that it was Take of the Day even though I hadn't used any new products, I mean its clinique?! But I started doing patch tests on the back of my hand and on the inside of my forearm and within seconds the skin would go red and start itching. I also did the same patch tests with all my other facial products and nothing happened with those.
I asked a few people "in the know" and they mentioned a protein in Take of the Day that over time can suddenly cause quite sever reactions and they said they wouldn't recommend it to anyone for continuous use due to this as people like me who have never really had reactions to anything at some point are very likely to have a reaction to this.
I still use some Clinique products like All About Eyes cream and concealer but I will be staying clear of there facial skincare range in the future. Which is really annoying as I have loved Clinique for years!!
I usually get Clinque products as gifts for Christmas so will not be able to comment on the price of this product but I guess it will be out of my price-range.
The packaging of this product is sleek, clean and professional. The cleanser is dispensed via a pump method which works well and is easy to use. I usually dispense the product (usually 2 pumps) on to a cotton pad and wipe over my face starting from the centre and moving outwards. The scent of the product is very calming and relaxing.
Even after a shower when I have washed my face with a facial cleanser, this cleanser will still pick up missed dirt and left over make-up from off my face and neck. The only place where this cleanser does not pick up as much dirt are on the eye lashes but Clinque's Take the Day Off for Lids, Lashes and Lips will do that job more thoroughly and I usually follow up with that cleanser within my daily skin care routine.
By far the best cleanser I have used. It would be good if you didn't have to use a second product for the removal of more stubborn mascara. I have combination skin which isn't a problem for this product and I would recommend this to any one.
I am very keen on good skincare. If my regime is not perfect, I will break out in spots left right and centre. Unfortunately I have found the premium ranges of products (such as Clinique and Calrins) much better at controlling my skin. However this comes at a price! I love Clinique take off the day cleaning milk. It costs around £17 in a department store (they normally have offers on where you buy a couple of bits and get loads of little samples and bits free though) or you can shop around on the internet and get it a bit cheaper.
Clinique take of the day cleansing mil comes in a tall cylindrical bottle. The packaging is simple but funky, and it is clear you have bought quality. The bottle is slightly purple. It has a dispensing arm coming out of the top, which you press down to get a bit of the product out of. After a few practises you can easily get the hang of how hard you press, for how much you wish to get out.
The product itself is a whitey colour with a creamy consistency. The texture is incredibly smooth. I blot some onto a cotton wool pad and rub it onto my face, starting with my eyes to remove my make up. The cream glides on so easily and feels lovely and soft. It doesn't sting my eyes at all, or irritate them and they can be really sensitive with other cleansers. I end up using about three cotton wool pads for my eyes and face. This does a fantastic job and I just keep rubbing until the cream comes off clean!
After use my skin feels so silky and soft. I do use a wash on and off cleanser afterwards, because otherwise my grease builds up in my pores, but this is a fantastic product for the first steps. I would recommend it's use in conjunction with Clinique foaming face wash and Clinique dramatically different moisturising cream. The three perfect steps for awesome skin!
I've got extremely sensitive skin and I generally buy the Simple products as they're fragrance and colour free. However, I found that the Simple Kind To Eyes Make Up Remover made my skin feel very oily and greasy, despite it being naturally dry.
I was advised by my hairdresser to try the Clinque products as they're gentle on skin and they moisture as well as cleanse. I bought this Take The Day Off Moisturising Milk by Clinique from my local department store for £16.50, which seemed extremely expensive at the time compared to the £3 I would normally pay for the Simple products.
However, when I first used this product I knew it was worth it - I only needed to use two squirts from the pump to remove all of my daily make-up, that's foundation, powder, blush, eyeshadow, mascara and lipstick! From that first use I decided that it was definitely worth every penny - I knew it was going to last for ages.
The product itself has no fragrance so it's pleasant to apply, and the milk is quite thick and creamy. When I use this product I apply one squirt to a flat piece of cotton wool and wipe it across my lips and both my eyes, then use my fingers to massage my eyelids and lips in circular motions, before tissuing the excess milk and removed make-up away. I repeat this process but I spread the cream across my forehead, chin and cheeks, massaging in circles and tissuing away any excess. After use my skin feels refreshed and hydrated, completely moisturised and there's never a trace of my make-up left on!
I bought my first bottle last Christmas, when my skin is at its driest in the winter, and I'm only onto bottle number two and I use it around four times weekly. However, this of course depends on how much make-up you wear and how much moisturiser you have to use to remove it.
I will never go back to my old make-up products, I've tried a lot of the Clinique range now and I love it all! I would definitely suggest this product to anyone with quite dry or sensitive skin as it really does refresh and hydrate dry and cracked skin as it removes every day/night make-up. Sometimes I've used the product as a moisturiser when I'm not wearing any make-up and it just works wonders on my dry skin!
Being a fan of Clinique skin care products generally, I was excited to try this cleanser. I think the mark of a good cleanser is how well it sits on your skin. A lot of cleansers are quite thin and therefore, once applied to the skin can start sinking in - rather like a moisturiser. This one however stays on the surface of the skin and allows you to move it around the surface, thus picking up all the make up that you are trying to remove. It leaves your skin with a wonderful sheen and because of the thickness of the cream, you won't get through it too quickly.
The cleanser comes in a decent sized, pump action bottle. This is generally very handy, although once you are closing in on emptying the bottle it can become an absolute pain to dispense and will - rather annoyingly - involve lots of banging around to get the cream in the right position for the end of the dispener. So basically you have to line up the cream with the dispenser tube and as the cream is quite thick, this can take time.
All in all though I would highly recommend this as a cleanser as it really does remove all traces of make up. It cannot be used on eyes which is a little unfortunate, but if you have a good skin care routine in place then this shouldn't matter. It's a little more expensive than a lot of other cleansers available, but I would say this product is definitely worth the money as you won't get it through it as quickly as you would with other cleansers as you don't need as much. For me, the main reason I love this cleanser so much is because it makes your skin feel so soft and smooth afterwards. You're left with clean skin without that horrid tight feeling that you can often get after cleansing. I also much prefer cleansing with a wipe off cleanser like this one, as apposed to a wash off cleanser as I find it much less fussy.
I would suggest following this up with one of the Clinique clarifying toners that is best suited to your skin type, however obviously any toner would suffice.
Gentle, milky makeup dissolver removes even long-wearing facial makeup and sunscreens, then tissues off or rinses away with water. Residue-free formula leaves all skin types soft, comfortable. For all skin types; ideal for drier skins.


text: 'Tis the season to get some wins By Dave Hickman December 18, 2012 Story Share The Associated Press WVU forward Keaton Miles drives to the basket against Michigan guard Tim Hardaway Jr. on Saturday. The Associated Press West Virginia forward Keaton Miles (55) drives to the basket against Michigan guard Tim Hardaway Jr. (10) in the first half of their NCAA college basketball game at the Barclays Center, Saturday, Dec. 15, 2012, in New York. (AP Photo/John Minchillo) MORGANTOWN - It is what it is for West Virginia's basketball team nine games into the season. And it is not pretty.The Mountaineers are just 4-5, have lost by a combined 49 points to the two ranked teams on the schedule so far, have a collective shooting percentage that ranks No. 311 out of 347 teams nationwide (327th where 3-pointers are concerned) and have drawn the wrath of coach Bob Huggins not as much for poor play as even poorer effort.Far from throwing up his hands in disgust, though, Huggins is trying to keep a positive outlook."Honestly, we let a couple of games get away that we shouldn't have let get away,'' Huggins said Tuesday, referring specifically to a three-point loss to Davidson and an ugly setback in which his team lost a 15-point lead at Duquesne. "If we don't let those get away, we're 6-3 and people think we're pretty good.''Well, perhaps not pretty good, but at least better than what seems the current impression. The Mountaineers still have a 34-point loss at Gonzaga on the resume and that meltdown against Duquesne, defeats good teams just don't suffer.Still, there is plenty of time to work on a resume and get to the point where "pretty good'' isn't a pipe dream. It will take stringing together a few wins at home in order to establish some confidence and if that's going to be done now is the opportunity.A West Virginia team that has played just twice at the Coliseum - no small matter in analyzing the sub-.500 start - will do so for three straight games against mid-major, non-conference opponents. It starts tonight with a 9 p.m. game, televised by ESPNU, against Oakland.On Saturday afternoon the Mountaineers host Radford and then, after a week off for Christmas, host Eastern Kentucky on Dec. 30.None of those teams are intimidating, but neither are they walk-overs. Oakland is but 4-7, but has played the No. 40 schedule in the country according to the Rating Percentage Index. The Golden Grizzlies beat Valparaiso Monday night 70-68 and took Pitt to overtime a month ago. Radford, meanwhile, is 5-5, while Eastern Kentucky - coached by former WVU assistant Jeff Neubauer - was 9-0 before losing by 13 at No. 10 Illinois Sunday. The Colonels are in the Top 100 of the RPI, but have also played the nation's 322nd-ranked schedule.Huggins knows that a sweep of those three teams isn't going to dramatically change any perceptions of his team, but at this point the Mountaineers just need to string together some wins before Big 12 conference play begins with another home game, against Oklahoma, on Jan. 5. Then it's back on the road for three of the next four games."I don't know if anybody in the country has only played two games at home by now,'' Huggins said. "Now we've got some at home and hopefully we can get some momentum going.''Despite Huggins' rather lengthy outburst concerning the effort of some of his players following Saturday night's 81-66 loss to unbeaten and No. 3 Michigan in Brooklyn, the Mountaineers did show some signs of improvement. They shot less than 40 percent again, but had a couple of hot-shooting streaks (including 12 of 18 to start the game) and with 41/2 minutes to play had erased much of an 18-point deficit to get within seven points of the Wolverines.But there were also the continued problems of scoring inside and making shots consistently, two things that go hand in hand. Without the threat of that outside shooting, opponents are collapsing against Deniz Kilicli and the other inside players, and they aren't responding well. Kilicli missed his only three shots against Michigan and just minutes into the second half, Huggins sat him down, essentially for the rest of the game. Kilicli showed up early for practice Tuesday and spent a great deal of time working around the basket against team managers pounding him with pads. West Virginia might also return 6-foot-10 Aaric Murray to the floor after Huggins left him at home for the trip to Brooklyn. Huggins said Murray's attitude had been better the past two days and said he would likely dress for the game, but was noncommittal on actually playing him.Perhaps the most encouraging sign from the Michigan game was the play of freshmen Terry Henderson and Eron Harris. Henderson scored 23 points and Harris 10 and both made some clutch shots. It's one of the few times this season that anyone has made outside shots for the Mountaineers.Oakland brings to the Coliseum a fairly veteran team that plays only one freshman in the rotation.Most of the scoring is done by 6-5 junior guard Travis Bader (19.6 points per game), 6-4 junior guard Duke Mondy (13.1) and 6-10, 245-pound sophomore forward Corey Petros (14.9). The Golden Grizzlies have only two players in the rotation who stand over 6-6.nnBRIEFLY: West Virginia has played Oakland just once, a 95-71 win in the 2010-11 season opener. Despite that 4-5 record, West Virginia is still No. 75 in the RPI. That's in part because the Mountaineers' schedule to date is ranked No. 15. It's the most difficult schedule to date among the 10 Big 12 schools. Kansas' schedule is No. 16. Texas Tech's schedule is ranked No. 345.Reach Dave Hickman at 304-348-1734 or email@example.com or follow him at Twitter.com/dphickman1.Oakland at WVUWhen: 9 p.m. todayTV: ESPNULine: West Virginia by 11 Story Share Story Share Trending Now 1 Facebook founder visits Charleston restaurant 2 Innerviews: Dual-identity surgeon riding high in horse racing world 3 Safety shutoff disabled prior to June coal-mining death, report says 4 Gazette editorial: Capito has second chance to do the right thing 5 WVU seeking improvements during off week WVU's Bailey explains decision to go pro Previous Story Herd can't sleep on Savannah St. Next Story


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NEW YORK ( TheStreet) -- Major U.S. stock averages rose Tuesday, with the benchmark S&P 500 hitting a five-year high, as investor sentiment improved on yet another set of deals headlines, this time about a possible merger of OfficeMax ( OMX) and Office Depot ( ODP). Investors remained concerned, however, as the U.S. sequestration deadline loomed. There are now less than two weeks left before the next fiscal cliff of automatic spending cuts kicks in March 1. President Barack Obama on Tuesday urged Congress to find a way to avert the sequester, emphasizing the negative effect it could have on the economy and job creation. "If Congress allows this meat-cleaver approach to take place, it will jeopardize our military readiness, it will eviscerate job creating investments, and education, and energy, and medical research ... it doesn't make those distinctions," he said. The Dow Jones Industrial Average closed up 54 points, or 0.4%, to 14,036. The blue-chip index began the session up nearly 7% so far in 2013. Breadth was positive, with winners outnumber losers 22 to eight. Top gainers included Pfizer ( PFE), General Electric ( GE), Cisco ( CSCO) and Merck ( MRK). UnitedHealth ( UNH), Alcoa ( AA) and Wal-Mart ( WMT) were among the laggards. UnitedHealth shares shed 1.1% and Humana ( HUM) plunged 6.4% as the Centers for Medicare and Medicaid Services proposed worse-than-expected 2014 Medicare Advantage rates. The S&P 500 added 11 points, or 0.7%, to 1,531. The Nasdaq tacked on 22 points, or 0.7%, to 3,214. Most sectors in the broader market, with the exception of basic materials, climbed higher, led by conglomerates, consumer non-cyclicals, energy and utilities. Volumes totaled 3.72 billion shares on the New York Stock Exchange and 1.84 billion shares on the Nasdaq. Advancers were outpacing declines by a ratio of 2.2-to-1 on the Big Board and 2.1-to-1 on the Nasdaq. Ed Yardeni, chief investment strategist at Yardeni Research, said despite the U.S. fiscal worries, the rise in payroll tax receipts in January, and jitters ahead of the Italian elections, there has been an "impressive" rally in stock prices so far this year amid ongoing deals headlines. "Why hasn't the market sold off in anticipation of these potentially unsettling events? The recent wave of mergers and acquisitions is a reminder that corporations and private-equity investors have lots of cash available for such deals," said Yardeni. He noted that, in the past, the bull market since March 2009 has mostly been driven by corporations using their abundant cash flows to buy back shares and pay out more dividends. "Now they may be about to add M&A to their bullish activities," said Yardeni. Gold for April delivery fell $5.30 to settle at $1,604.20 an ounce at the Comex division of the New York Mercantile Exchange, while April crude oil futures closed up 69 cents at $97.10 a barrel.
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Family Preservation Services - Domestic Violence Services
Specialized support in situations
involving domestic violence
Domestic violence is caused by stress, substance abuse, or mental health issues.
Domestic violence is about power and control. It is behavior that is consciously chosen to control or dominate a partner.
DOMESTIC VIOLENCE is a pattern of behaviors used by one person to gain power and control over another person in an intimate relationship. It occurs in many kinds of intimate relationships, married and unmarried, and among people of all racial, ethnic, economic, educational, and religious backgrounds and sexual orientations. Domestic violence is present in 30 to 60 percent of the cases of child abuse and neglect nationwide.
Fairfax County's Department of Family Services can offer special support in domestic violence situations.
Everyone has the right to be safe in their own home.
In 2005, Fairfax County's Department of Family Services created a special Domestic Violence Unit to provide additional services in situations involving domestic violence in which children are at risk for abuse or neglect. The DV Unit is part of Family Preservation Services in the Children, Youth and Families Division of DFS.
Who is eligible for DFS domestic violence services?
To be eligible for DFS domestic violence services, a client must want the assistance and already be receiving services from one of the following Department of Family Services programs: Child Abuse Prevention Services, Child Protective Services, Family Preservation Services, or Foster Care and Adoption.
How can the DFS Domestic Violence Unit help?
Secondary Case Management
In situations involving domestic violence where children are at risk for abuse or neglect, the DV Unit provides a second social worker to work with the primary child welfare worker. The DV social worker helps the primary social worker assemble the services best suited for the victim and children, with safety as the main goal.
Direct Client Services
The DV Unit provides direct client services, including:
- Individual client education regarding aspects of domestic violence such as power and control, the cycle of violence, safety planning, the impact of violence on children, healthy relationships, characteristics of batterers, and options counseling and assistance.
- Assistance with obtaining protective orders and accompaniment in civil and criminal court hearings.
- Referrals and help for victims and children to find emergency shelter, public assistance, legal services, mental health support and other services, depending on individual needs and circumstances.
Training and Outreach
The DV Unit offers training for all DFS staff on available services and best practices for working with victims of domestic violence and their families. Community outreach and education is another key role of the DV Unit. Bilingual social workers collaborate with community-based organizations to provide seminars and support groups.
Coordinated Community Response
The department's domestic violence social workers are part of the countywide effort to establish and strengthen a coordinated community response to domestic violence, to ensure best practice in service delivery and to improve the lives of children and families in Fairfax County. Everyone has the right to be safe in their own home.
For more information about the Department of Family Services'
Domestic Violence Unit,
call: 703-324-7563; TTY 711


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STAGE TUBE: Director Anne Kauffman Talks Labyrinth's THE MUSCLES IN OUR TOES
In the video below, director Anne Kauffman talks about working on the new comedy THE MUSCLES IN OUR TOES by Stephen Belber with cast member Amir Arison at the Brass Monkey Bar in New York City. Belber's play is part of the 2013-14 Season at Labyrinth Theater Company. Click below!
The New York Premiere of The Muscles in Our Toes begins performances on June 14, with an official opening night set for June 26, 2014, at Labyrinth's home in New York City's West Village, the Bank Street Theater (155 Bank Street). The complete cast of The Muscles in Our Toes includes Amir Arison, Nadia Dajani, Bill Dawes, Samuel Ray Gates, Matthew Maher, and Mather Zickel.
In this dark comedy, four friends meet at their high school reunion, and ponder a plan to free their old friend who's been kidnapped by a radical political group. Absurdity, intensity and plain ole weirdness ensue when this inebriated, stoned, adolescently arrested, religiously confused group of friends attempts to tackle the task at hand and at the same time, debate the forces of international terrorism.
The design team for The Muscles in Our Toes includes 2014 Tony Award nominee Japhy Weideman (Lighting Design), Lee Savage (Set Design), Emily Rebholz (Costume Design), and Jessica Paz (Sound Design).
Labyrinth Theater Company is devoted to providing affordable ticket prices for the community. We are pleased to announce that tickets for The Muscles in Our Toes are $20 when purchased on or before June 25. After that date, tickets prices will be available starting at $35. Tickets are available online at labtheater.org or by calling (212)513-1080. More information is available at http://labtheater.org/the-muscles-in-our-toes/.
Click Here to Watch the Video!


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ORLANDO, Fla. - A man was arrested and sprayed with a chemical agent after he tried to walk out on his bill at High Tide Harry's on Wednesday, while pulling a knife on the manager who tried to confront him.
Police said that Thomas Knight, 41, tried to leave the High Tide Harry's on Semoran Boulevard Wednesday afternoon without paying his bill, when the manager confronted him. Knight then pulled out a 4-inch folding knife from his pocket, but the manager was able to detain him until authorities arrived.
Knight repeatedly squeezed an officer's hand while he was being handcuffed, prompting police to deploy a chemical agent before arresting him, police said.
Knight faces multiple charges, including aggravated assault with a deadly weapon, battery on a law enforcement officer, theft from a dining establishment and resisting a merchant.
Copyright 2013 by ClickOrlando.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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ebrary is an information delivery service that features a growing selection of more than 36,000 titles from more than 200 leading academic, STM, and professional publishers.
ebrary allows an unlimited number users of any one book in the database at any given time. Portions of books may be downloaded as PDF files, and entire books may be downloaded and read using the Adobe Digital Editions reader.
Resource URL: http://site.ebrary.com/lib/brooklyn/
Vendor: ProQuest
Online Help: Click on "help" in upper left


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Friday, September 22, 2017
Anxiety and Stress Disorders
Practicing OCD
My 10 year old daughter has OCD and she often insists things be washed that she thinks are contaminated in some way. Depending on how upset she gets, I just do whatever it takes to get her to forget about the problem, no matter how ridiculous or how much time it wastes. Lately, I`ve been making her do the extra washing, spraying, cleaning, etc. It obviously isn`t helping her by having her do the work. My husband thinks we should refuse to do unreasonable requests for her because it encourages her and if she has to spend her own time, she`ll get over this. All I see happening is that she gets even more upset over stupid stuff.
These are important issues to discuss with your daughter's physician and/or therapist. I am hoping that your daughter, and your family, are getting some regular therapy. If not, I strongly encourage you to do so. OCD (Obsessive Compulsive Disorder) is a specific type of anxiety disorder where a brain chemical imbalance leads to increased anxiety for sufferers. People with OCD find that obsessions (repetitive thoughts) or compulsions (repetitive actions) help to decrease the severe anxiety they are feeling. It is highly unlikely that making your daughter spend her own time on the obsessions or compulsions will make her "get over this." The OCD actions help a person live with their extreme anxiety, and until the underlying problem is treated, the compulsions tend to persist.
Medications are highly effective in OCD, as are various forms of therapy. I encourage to seek guidance from a trained professional (because of your daughter's age, I would recommend a child psychiatrist) if you are not already doing so.
Good Luck.
Nancy Elder, MD
Associate Professor
College of Medicine
University of Cincinnati


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BERLIN, N.J. A.C. Moore Arts & Crafts reported that sales for the second quarter of 2010 were $99.9 million, a decrease of 4.3% compared with sales of $104.4 million during the second quarter of 2009. This decline was primarily due to a decrease in comparable-store sales of 5.9% partially offset by the operation of two additional stores compared to the second quarter of last year. Net loss for the quarter was $9.7 million, or 40 cents per share, compared to a net loss of $8.1 million, or 38 cents per share in the second quarter of last year.
Joseph Jeffries, CEO, stated, "We will not be satisfied until we return to sustained profitability. I am confident that we have both the right team and strategy in place. We will continue to focus on our merchandise plan, remodel program, and store level execution to drive improved performance."


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Deerfield, Ill. -- Walgreens and BMW Manufacturing on Tuesday celebrated the grand opening of a comprehensive worksite health center on the BMW campus in Spartanburg, S.C.
The 25,000-sq. ft. facility, managed by Walgreens Employer Solutions Group, will provide BMW associates, dependents and eligible retirees a wide range of health services, including primary and occupational care.
"Walgreens has increasingly shown how investing in worksite health programs can be instrumental in helping to reduce costs for employers, while improving the overall health and productivity of their workforce," stated Peter Hotz, Walgreens group VP.


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Quoting the competition number, please send your resume to:
Human Resource Services
Yukon College, Box 2799
Whitehorse, Yukon, Y1A 5K4
Fax #: (867) 668-8896
Email: firstname.lastname@example.com
Applicants should clearly outline all relevant qualifications since selection for interview will be based on applications submitted. A statement of qualifications, which outlines the selection standards, and a position description are available in PDF format for all Bargaining Unit positions, by following the links above.
Please be prepared to provide official transcripts upon request.
We wish to thank all applicants for their interest, but advise that only those selected for an interview will be contacted.


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Staub Cast-Iron Paella Pan
- Summary
Staub's innovative enamel coating takes cast-iron cooking to the next level with improved performance, style and durability. The low, shallow shape of this paella pan promotes the evaporation of liquids. After cooking, it doubles as a striking serving piece.
- 15 1/2" diam., 2 1/2" high.
- Heavyweight enameled cast iron transfers and retains heat evenly.
- Multicoat enameling creates a glossy, vibrantly colored "majolique" finish that resembles fine ceramics.
- Resistant to rust, chipping and cracking, the coating requires no additional seasoning like some other cast-iron pieces.
- Specially formulated black matte interior enamel contains traces of quartz, giving it additional heat resistance and a rougher surface for better browning.
- Smooth enameled base compatible with all cooktops, including induction.
- Dishwasher safe.
- Made in France.
- Dimensions & More Info
- 15 1/2" diam., 2 1/2" high.
- Made in France.
- Use & Care
- Ideal for use on any cooktop, including induction.
- Oven and broiler safe up to 500°F.
- For best results use low to medium heat.
- When using high heat, bring your pan slowly to a high temperature.
- Use plastic, wood or nylon utensils only; Metal utensils may damage the enamel.
- Enamel may chip or crack if banged against a hard surface.
- Handles can become very hot. Always use a pot holder or glove when handling.
- Allow pan to cool before washing.
- Dishwasher safe.
- Stubborn stains can be removed by soaking your pot for a few minutes in hot soapy water.
- Completely dry pan before storing.
- Avoid using steel wool, steel scouring pads, harsh detergents, bleach or abrasive cleaners.
- Shipping
Shipping Information
UPS can deliver most in-stock items within 4-5 business days. UPS is unable to deliver to P.O. boxes.
Shipping Rates
The shipping rate varies depending on your order total and shipping destination. View Shipping Options and Charges.
Next Day Delivery
For an additional charge of $17.50 per address, we can expedite delivery to most destinations. This service is not available for some oversize items, items shipped directly from the supplier (including perishable and custom-manufactured items), out-of-stock items and items to be shipped outside the contiguous 48 states.
Orders received by 9:00 p.m., Eastern time, Monday through Thursday will arrive the next business day; orders placed Friday through Sunday will arrive on the following Tuesday.
Return Policy
At Williams Sonoma, we take great pride in the quality and craftsmanship of our products. Attention to design, materials, safety and construction are our priority. Upon receipt, please inspect your purchase and notify us of any damage; we will arrange for a prompt replacement.
If within 30 days, you are dissatisfied for any reason, you may return your purchase for a refund of the merchandise value. An original receipt or gift receipt is required for all returns and exchanges. Returns with a gift receipt will be refunded in the form of a Merchandise Credit for the amount indicated on the gift receipt. Returns with original receipt will be refunded in the original form of payment, cash and check refunds over $100 will be issued as a company check (may take 14 business days from time of request).
For all cutlery returns (knife sets, single knives, cutting boards, knife sharpeners, and knife storage) please contact us at 888.922.4108 to initiate the return.
We cannot accept returns on monogrammed, personalized, special-order items, custom upholstery, food, items shipped direct from the vendor, or on items damaged through normal wear and tear. Final sale items ending in .97 or .99 cannot be returned.
Made to Order and Final Sale Furniture items are non-returnable, and cannot be cancelled once the order is placed.
For returns of items purchased from your Williams Sonoma Gift Registry, we will gladly provide a refund or exchange for the merchandise within 90 days of your event or within 90 days of purchase, whichever date is later. View Full Returns Policy.
- More about Staub
Staub traces its origin to the Alsace region of France, where founder Francis Staub designed his first enameled pot while working in an old French artillery factory in 1974. With the goal of creating the perfect pot for cooking the region's traditional hearty soups, stews and braises, he combined cast iron, the most popular material of the time, with the latest enameling technology available. Today, Staub still makes its cookware at a traditional atelier in France, casting each pot in an individual sand mold, which is heated to 800°F and destroyed after use. The exterior enamel coating is made with glass powder and mineral pigments, applied in two or three coats to generate brilliant glossy colors.
Rated 5 out of 5 by LeMagalhes from My favorite Pot for making paella It's perfect to cook for 10 people. It's large. I like It so much!Date published: 2016-06-20Rated 5 out of 5 by Nanaimo from THE BEST PAN EVER This pan is incredible .. it is truly an heirloom piece. Sturdy weighty and preseasoned. One of the best investments that I have ever made, because of it's size I use it for everything...thank you Staub (and William Sonoma)!!!Date published: 2016-05-23Rated 5 out of 5 by DmcSeattle from Attention Serious Paella Chefs This was my first piece of Staub purchased over 5 years ago and now my collection is up to 5 pieces. I can't say enough good things about Staub. The Even heat, browning and cleaning properties are unsurpassed by any other manufacturer I have tried. And believe me, I've tried all the principles out there. This pan is amazing and will produce the perfect paella with the added benefit of looking absolutely beautiful as a center piece for casual dining. If your Staub isn't performing beyond your expectations, go consult with a representative about what's going on cause these pans are everything a serious cook or professional chef dream off. Note: For Serious cooks, only. if you cook everything on the highest heat possible or don't have the patience to bring your Staub up to the temperature you want then these aren't for you.Date published: 2016-01-12Rated 5 out of 5 by sailorgal from What a beauty! This Paella pan is so beautiful. It's large, but conducts heat so well I can use it on my glass top stove on the largest burner. My first attempt at Paella was a great success. I am going to make it for a showy Christmas dinner with our family. I wish it had a lid. I used aluminum foil at the end to keep it warm. I will try this pan for other dishes. . . maybe potato casserole, searing steaks, etc.Date published: 2015-12-06Rated 5 out of 5 by Leadball2 from Excellent Paella Pan I have been cooking Paellas for 25 years, my signature dish. The first one I made in this pan was superb. My gas cooktop is inadequate for this monster pan and I used a large outdoor camping propane cooker. First I sautéed sliced pieces of boneless skinless chicken thighs in olive oil and they stuck to the pan. This turned out not to be an issue as I scraped off the residue with a sharp plastic spatula and continued with the process. (I was worried it would burn and ruin the Socarrat). The thick cast iron bottom of this pan distributes the heat incredibly well and once the liquid was added and came to a boil the paella bubbled along in a very uniform fashion. The Socarrat came out perfect and the pan looks great on the table! Clean up was a breeze. Next my wife made a double batch of gorgonzola scalloped potatoes in the oven that we served with deep-fried turkey. They came out perfect, actually the best ever, and again cleanup was a breeze. I am very happy with my Staub paella pan.Date published: 2015-11-10Rated 5 out of 5 by Slclarry from Love this pan My burners aren't wide enough to use this pan without hot-spots so I haven't gotten good use out of it on the stovetop. I'm getting a 14inch Italian paella burner and putting it next to the grill so that will fix that problem. However... I finally can cook enough oven-fried chicken for the family in one pan. It comes out perfect and I'd be perfectly happy with the pan if that was the only thing I used it for.Date published: 2015-05-31Rated 3 out of 5 by mpstat from Good size but.... I do not use it for paella, and bought it primarily for making home fries with large potato wedges. Giving it 4 stars because potatoes get stick to the bottom of the pan no matter on a cooktop or in an oven, and I have to scrape them off the bottom, so they get mis-shaped. Another negative this item comes without a lid. Thus the application is limited. Would it have at least a lid I would rate it higher.Date published: 2014-04-12Rated 5 out of 5 by Cassano from Best paella pan ever Always have had trouble getting the rice in the paella to come out consistent. This heavy pan has solved this problem, It is also great for the best pan fried chicken (crispy golden, with moist inside)Date published: 2014-03-04


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Nobody important wants to become a sequester expert, I suppose, because that means the sequester will be long-lived and its unwanted ills will be visited on nearly every federal program.
The effect of the sequester cuts on the budgets of federal agencies is being debated on a day by day, hour by hour basis. The buzz this week is that President Obama "overhyped" the automatic spending cuts. However, as some of the cuts become more deeply felt that may well change.
In the stories I have read, I haven't seen the link to the Office of Management and Budget's master document detailing the administration's cost-cutting plans for various agencies.
After asking in a Freedom of Information Act request for the USDA AMS plan for sequester cuts, the USDA FOIA officer sent me a link to fulfill that request. If you want every last detail on sequester cuts for all federal agencies, check out the 83-page document for the skinny on how government will cut the fat.
My Twitter account is recently passed the 2,000 follower plateau, though some of my newest followers include an automotive shop, a youth pastor and yes, more ever-abundant social media marketers.
And so the adventure in social media continues. One useful Twitter tool I found this week is called Twittercounter ; useful for tracking the escalating number of my auto shop followers.
Speaking of social media, one poll question at the Fresh Produce Industry Discussion Group this week addressed the biggest weakness in Wal-Mart's fresh produce departments.
And Wal-Mart, the market research is on me. I asked, "What is generally the biggest weakness in Walmart's fresh produce departments?"
The options are : out of stock, marginal quality, selection, freshness and identity.
Too early to tabulate the poll results, but early comments didn't hold back on Wal-Mart's shortcomings.
For all of Wal-Mart's success and future aspirations to buy local and save consumers billions, it seems the chain still needs to up its performance at the department level. Drawbacks include lack of training for produce department staff and low quality produce in some stores. Lack of attention to RPCs on display also hurt their image, one observer said, and culling was not aggressive enough to removed bruised or old product. One reader advised,
"The better merchandising retailers focus attention on the display throughout the day. Putting out what sells on a timely basis instead of piling it up high is better for the product and quality for the consumer. Take a look at the attention that someone like Wegman's gives at each item on display throughout the day."
Sure Wegman's is a high bar, but readers think Wal-Mart can be better. Like I said, the market research is on me, Wal-Mart.
Another nifty web tool I found this week is the USDA's http://1.usa.gov/YEz8nW Food Access Research Atlas. Plug in your address and you can see whether you live in a food desert or food oasis.
And, of course, follow me on Twitter @tckarst and check out The Packer new social site, The Packer market.
Check out the new USDA's series on the distribution of the Food Dollar. In 2011, the farm share of the food at home dollar was 22.9 cents, while the market share was 77.1 cents.
Retailers can't be accused of taking ever larger margins from growers, however. Compared with a high of 24.8 cents six years ago, the retail share of the at-home food dollar shrunk to 21.4 cents in 2011, the lowest point since 1993. Maybe we can at least credit Wal-Mart for lower retail margins, perhaps?


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Welcome to the Disability Services Center. The DSC provides a wide range of services to qualified students with physical, psychological and learning disabilities enrolled at USM.
Our mission is to work together with students, faculty and staff to create an environment of equal access allowing students to explore and recognize their full potential. We strive to minimize physical and attitudinal barriers and to build relationships with the larger community that enhance the learning and life experiences of our students.
The staff of DSC looks forward to working with you to help you achieve your educational goals at USM.


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MONTEREY, Calif. — Chefs were everywhere at the Produce Marketing Association Foodservice Conference and Expo as the trade group pushed to deliver on its promised theme, Innovate the Plate.
They were manning booths, roaming the show floor, featured as panel speakers and, as always, competing with each other.
"The food element of the show is really starting to percolate up, which is indicative of where the industry is going," said Dennis Donohue, president of Salinas-based Royal Rose LLC. "You've got to move beyond fresh and get into the food business. There's a lot of activity around flavor, new ideas and being innovative with fresh."
"The Innovate the Plate theme was a great hit," said Bryan Silbermann, president of the Produce Marketing Association. "We had great attendance by foodservice operators, especially on the menu development and procurement side. There was wonderful involvement from all of the distributor community, the broadline and produce specialty houses."
Ashley Boucher, PMA public relations manager, estimated more than 1,700 people attended the 32nd annual trade show July 26-28 in Monterey, along with 163 booths. Final numbers were not immediately available.
"The crowds seem better," said Ty Schurman, salesman and commodity manager at Ocean Mist Farms. "This show has a lot more draw than past years I've seen."
"There will be a lot of new business as a result of this," said Jeanette Hertzler, regional saleswoman for GreenGate Fresh.
Edward Gotterba, foodservice sales representative for The Produce Exchange, said he'd be happy to return to his spot near the entry to the expo floor.
"We get a big rush just before the show opens, then once they're in the building we don't really get people coming back out," he said. "But we like the exposure here. People who don't have badges can come by."
Award winners at the conference included:
- Best new product launch: Naturipe Farms, for plastic-conserving peel and reseal berry packaging;
- Sensory experience: Mann Packing Co., for Arcadian Harvest Ruby blend steak salad;
- Chef demos lunch: The Mushroom Council and chef Steve Solomon, for their mushroom and beef blended burger sliders; and
- Best of show: Rocket Farms Herbs Inc., for its booth. Criteria include booth design, products and messaging.


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Topic: possible liver failure...
Hi everyone -
Its been about a week since I last posted my introduction. My grandmother has been recently diagnosed with cholangiocarcinoma. As I have already mentioned the only treatment plan for her was palliative care. The oncologist did place 2 metal stents to drain the bile duct and liver duct to alleviate jaundice and make her more comfortable.
She has been at home for about 1 1/2 weeks now. She is taking 1mL of morphine 3 times a day to control the pain in her abdomen and furosemide to assist with the ascites. We have tried some herbal treatments like milk thistile, neem water, aloe vera juice but its too early to tell if that is helping in any way.
Since yesterday we have noticed a few things happening that doesn't look good. The edema in her legs and feet has gone down but we have noticed that her skin is becoming jaundiced again, her skin is extremely itchy and there are spider veins all over her legs and feet.
One dr we spoke with said the itchiness is a side effect from the morphine and the jaundice may be because the stent is becoming blocked.
We spoke with her original oncologist and he explained to us that it appears my grandmother's liver is failing. The only recommendation he had was to keep her comfortable at this point.
I didn't expect this to be happening so soon. I'm not clear on what this means...how long does a person have once their liver starts failing?
I have seen some posts about CAAT as an alternative treatment...would it be too late to try this since her liver isn't functioning properly?
Any help is much appreciated


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1-2" 2007-2017 Jeep JK Adjustable Leveling Kit
The name Jeep is synonymous with rugged outdoor adventure. Few vehicles give the owner the feel that they can go anywhere they want when behind the wheel of the world's original SUV. Whether your adventures lead to the beach, mountains or any other activities that begin with getting behind the wheel of that new Jeep JK, ReadyLift has a new Jeep lift system that will make you look good getting there as well as increasing fenderwell clearance for those necessary off road wheels and tires.
Lets face it, a Jeep just doesn't look right unless it has aggressive off road terrain tires to go with that great Jeep off road look. ReadyLift's products deliver several lift options. Our new 3-in-1 adjustable height coil spring lift spacers allows you to select the height of front end lift that you want. Machined from 6061-T6 billet aluminum and featuring a Patent Pending unique design, you can choose adjustments from 1 inch, 1.5 inch or 2 inches of lift to get the look you want. This is the perfect kit for Jeep owners who have installed a front winch or heavy front bumper by helping to bring the front end back up to where it belongs.
The Jeep JK adjustable lift spacers allow for the installation of up to 33 inch tall tires and are guaranteed to Maintain Your Factory Ride! The kit comes with machined spacers for the front suspension along with all necessary hardware. Installation time is approximately 1 to 1.5hrs.
Installation Instructions
Additional Information
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|JK, JK Wrangler
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The Recon Tactical is our vision of what a practical, all-around medium profile AR barrel for rigorous tactical training, hardcore hunting or all-purpose field applications should be. The Recon can do it all-very well. Fluted barrel model reduce weight even further and increases stiffness to the barrel for no loss in practical accuracy. 5.56 NATO5.56 NATO was developed in the United States and initially chambered in the M16 rifle. It is the standard cartridge for NATO forces as well as many non-NATO countries. It is derived from, but not identical to, the .223 Remington cartridge. We use a NATO, mil-spec chamber in our barrels that is reliable and safe to fire both 5.56 and .223 Remington rounds. This common and easy-to shoot cartridge is ideal for defense, training and small-medium game hunting.
TR-556RC16F-19 Schematic
5.56 NATO Test Target
5.56 NATO Test Target


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Rivera amazes one year after knee injury
NEW YORK -- The calendar indicates a full year has passed since Mariano Rivera crumpled to a Kansas City warning track after stumbling in pursuit of a batting-practice fly ball, his right anterior cruciate ligament torn and his baseball future in serious doubt.
One day later, after a night of quiet reflection and soul-searching in his hotel room, Rivera hobbled into the visiting clubhouse of Kauffman Stadium and vowed, "I am coming back. Put it down. Write it down in big letters. I'm not going down like this."
Months of intensive, grueling rehabilitation followed, and as Rivera worked his knee back into the shape necessary to handle a big league pitching regimen, the future Hall of Famer acknowledged that there were moments of doubt in which he wondered if he would actually make it back.
But his surgically repaired knee passed every winter test, breezed through a Spring Training workload with no issues, and the 43-year-old all-time saves leader hasn't seemed to skip a beat as he started his final Major League season a perfect 11-for-11 in save opportunities.
"I said all along that it wasn't his arm, so I wasn't really concerned about the type of stuff that we would see from Mo," Yankees manager Joe Girardi said. "Maybe the most amazing thing about Mo is that he's still doing it at his age.
"But he's been consistent his whole career. He's had the same mentality his whole career. But to be doing it at his age is really incredible."
In a way, it is because Rivera fell while chasing Jayson Nix's outfield drive on the afternoon of May 3, 2012, that he has been able to enjoy a farewell tour throughout the big leagues. Rivera said this spring that he had decided '12 would be his final season, a fact he had dropped hints about but had not been ready to officially reveal at the time.
Rivera made sure no one had any doubts this spring, announcing his intention to call it a career in a March 9 news conference in Tampa, Fla., saying that his tank was nearly empty and he intended to fully exhaust those last few drops on the diamond this year.
"If I would have finished the season last year, I would have retired last year, definitely," Rivera said. "I didn't want to leave like that. I felt like I wanted to give everything and I still had something left. This year, I knew what I wanted to do."
Bryan Hoch is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Johnny Altobello
A native of Cincinnati, Altobello moved to New Orleans as a child. After graduating from Warren Easton and then Loyola, he put together a storied 38-year high school coaching career, first at St. Aloysius (now Brother Martin) and then at De La Salle.
His career included coaching football and golf, but Altobello excelled on the baseball diamond and on the basketball court. He became one of the winningest basketball coaches in Louisiana sports history with a record of 589-92, an .865 winning percentage.
In six years at St. Aloysius, Altobello's basketball teams won six city championships and four state championships. His 1947 team, which included future Louisiana Sports Hall of Famer Nick Revon, Lou Bravo and Eddie Davis, was selected by The Times-Picayune in 2003 as one of the top prep teams of all time.
He also led his baseball teams to three city titles, four state titles and the national championship at Johnstown, Pa.
Altobello coached the bulk of his career at De La Salle, from 1953 to 1970. His Cavaliers won four basketball state championships, 16 district championships and 18 tournament titles. Three of his teams went undefeated (1948-49, 1950-51, 1956-57).
In 1995, De La Salle renamed its gymnasium the Johnny J. Altobello Sports Complex. He has been inducted into the Louisiana High School Coaches Hall of Fame, the Greater New Orleans Sports Hall of Fame, the Italian-American Hall of Fame and the Louisiana Sports Writers Hall of Fame.
Altobello died June 30, 2009 at 89 years old.
Source: New Orleans Times-Picayune


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Smith treating Petco Park like a bandbox
SAN DIEGO -- Outfielder Seth Smith has made Petco Park look small in the first two games of the season, hitting a home run in each game against the Dodgers.
Small sample size aside, spacious Petco Park doesn't seem to haunt Smith at all -- at least not in the way that it has several other position players over the years.
"I think your experiences help you," Smith said. "For me, it's more about when you're in the batter's box and how you feel, the batter's eye and the pitchers. There's no need worrying about the fences and the dimensions or how the ball flies.
"If you hit it, it's going to go. If not, it won't."
Of course, Smith spent the last two seasons playing for the A's and in their spacious ballpark.
Smith played four seasons at Coors Field with the Rockies before joining the A's. One of the things that general manager Josh Byrnes liked about Smith before he traded for him in November was the fact he played in Oakland's pitcher-friendly O.co Coliseum and wouldn't be put off by Petco Park's dimensions.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.


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Calycantus is a pretty wildflower. It blooms in the heart of winter and reminds us that spring is not far.
This morning I found them in my garden and, smelling it, I thought that children are like flowers.
Some of them bloom in winter; they are really brave.
Some bloom in spring, other in summer and the laziest in autumn.
The most important thing is that, early or late, everybody'll bloom!
What kind of flower are you?


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Tallmadge -- The driver of a vehicle that crashed into a Munroe Falls police car Saturday morning while driving around the Circle has been released from Akron City Hospital.
According to Tallmadge Police Lt. Ronald Williams, the city's emergency medical services transported the driver to the hospital for minor, unspecified injuries she suffered during the crash that happened around 9:30 a.m. She was released from the hospital Monday.
"She became disoriented as she went around the Circle," Williams said, according to witnesses. "She exited abruptly [at North Avenue] and went over a traffic [divider]. The patrol car was stationary on North Avenue, waiting to enter the Circle."
The cruiser was stopped behind another southbound-facing vehicle that wasn't struck.
An on-duty Munroe Falls police officer suffered bumps, bruises and abrasions from the airbag when the woman's vehicle hit his. Another Munroe Falls Police officer drove the injured officer to an unspecified Summa Health Care facility.
Williams said the woman allegedly had a medical condition that contributed to the manner in which she was driving. He declined to disclose further details because of medical privacy laws.
The crash damaged the left front areas of both vehicles. Both were towed from the scene.
It's unclear whether the woman was cited.
For more, see the Jan. 13 edition of the Stow Sentry.


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The "triggers" that initiate ME/CFS and other multi-system illnesses - Fibromyalgia (FM), Multiple Chemical Sensitivities (MCS), Lyme disease, Post Traumatic Stress Disorder (PTSD) and Gulf War Syndrome - are numerous and varied. However, because these diseases ultimately have consistent and often-overlapping symptoms, researchers believe there may be biochemical abnormalities common to all sufferers.
If a common biochemical abnormality can be identified, treatments directed toward this alteration might hasten resolution or at least provide significant improvement for those afflicted.
In the quest for a "unifying theory" of ME/CFS and related multi-system diseases, two models have emerged that have gained much scientific credibility. Research is revealing a connection between these complicated and misunderstood diseases and an equally complicated and misunderstood vitamin that may hold the key to improved health for many.
The Vitamin B-12 - ME/CFS/FM Connection
In searching for common biochemical threads among ME/CFS/FM victims, researchers have noted that symptoms of vitamin B-12 deficiency closely parallel those of ME/CFS and other multi-symptom diseases. In fact, symptoms overlap to such a great extent that many respected ME/CFS/FM researchers and physicians - including Drs. Paul Cheney, Charles Lapp, Kenny DeMeirleir, Jacob Teitelbaum, and Martin Pall - consider vitamin B-12 a mainstay of supportive treatment. (1-6)
One study found improved energy levels even in people who were not deficient in vitamin B-12 but were administered the vitamin anyway. (7) B-12 (2,500–5,000 mcg) administered every two to three days was associated with improvement in 50% to 80% of a group of people with ME/CFS. Most improvement was seen after several weeks of vitamin B-12 administration.(8)
The Curious Symptoms of Vitamin B-12 Deficiency
Best known for participating in the manufacture of red blood cells, B-12 is also needed for production and maintenance of the myelin sheath that surrounds nerve cells, and for manufacture and maintenance of DNA. (9-12) Participating in nearly every function of the body, vitamin B-12 deficiencies have widespread consequences.
So Is ME/CFS a Simple Vitamin B-12 Deficiency? Although B-12 deficiency symptoms share many commonalities with ME/CFS and other multi-system diseases, researchers do not suggest that these diseases are simply a vitamin B-12 deficiency.
Two emerging theories of biochemical abnormality are believed to be heavily involved in ME/CFS and other multi-system diseases. In fact, either or both of these models of biochemical abnormality might be a central cause of ME/CFS. Interestingly, both of these abnormalities are related to forms of vitamin B-12 deficiency.
The Nitric Oxide/Peroxynitrite ("No, Oh No!") Model of ME/CFS
ME/CFS and other multi-system diseases appear to be "triggered" by a wide variety of factors. Sufferers often report an initial viral, bacterial or other infection, a physical or psychological trauma, chemical exposure or other stressor before onset of symptoms. (38-41,43,48,50) In this regard, ME/CFS shares similarities with Fibromyalgia (FM), (44,45,48,50) Lyme disease, (47) Multiple Chemical Sensitivities (MCS), (46,48) PTSD (48) and Gulf War Syndrome. (40-42,48,49)
According to the theory of noted researcher Dr. Martin Pall, PhD, detailed in his book Explaining 'Unexplained Illnesses', ME/CFS and other multi-system diseases overlap in symptoms and initial triggers because they share a common metabolic origin, a 'vicious cycle' related to nitric oxide (NO-) and peroxynitrite (ONOO-) over-production. (51)
Because of the chemical abbreviations for these two substances (NO- and ONOO-) Dr. Pall calls this vicious cycle the "No, Oh No" cycle, and he presents solid evidence to make a case for this cycle as an underlying cause of ME/CFS and other multi-system diseases.
Dr. Pall has observed that virtually every known initiator of ME/CFS and other multi-system diseases either increases nitric oxide (NO) (52-62) or the superoxide radical (O2-) (63-66) or both. (54,57,73) These two molecules quickly react to form peroxynitrite (ONOO-), (67-72,79,81,85,115,117,121) a potent oxidant that is capable of damaging a wide range of biological molecules. (54,68,69,74-92)
Peroxynitrite (ONOO-) then acts through multiple mechanisms to regenerate O2- and NO-, the very molecules that create it. In this way, the NO-/ONOO- cycle becomes self-perpetuating, and a vicious cycle is initiated. (93-96) Unless something intervenes to break the cycle, it is possible that this biochemical "endless loop" could self-perpetuate indefinitely.
There is increasing evidence to support this pathway as a primary underlying abnormality in ME/CFS and other multi-system diseases. This runaway NO-/ONOO- cycle has also been associated with increased perception of pain. (53,59) [See Figure 1: The NO-/ONOO- Cycle, and Figure 2: Independent Consequences of Increased Superoxide (O2- ), nitric oxide (NO- ) and peroxynitrite (ONOO-).]
Figure 1: The NO-/ONOO- Cycle (click on image to enlarge)
Vitamin B-12: Which Form is Best?
What we know as vitamin B-12 is actually a collection of four related but different cobalt-containing molecules. Each of these forms plays a distinct role in the body as follows:
Hydroxycobalamin is a unique form of B-12 that quenches excess nitric oxide (NO?), the precursor to peroxinitrite (ONOO-).(147-149,172-176) Hydroxocobalamin (and methylcobalamin) also play a more important role in addressing neurological disorders than cyanocobalamin.(168)
Hydroxocobalamin participates in detoxification, especially cyanide detoxification. Cyanide levels are typically elevated in smokers, people who eat cyanide-containing food (like cassava) and those with certain metabolic defects. Excess cyanide in the tissues blocks conversion of cyanocobalamin to methylcobalamin or adenosylcobalamin. In such instances, hydroxocobalamin is the vitamin B-12 of choice.(169-171) Hydroxycobalamin is FDA- approved as a treatment for cyanide poisoning.(214)
Methylcobalamin is considered by many researchers to be the most active form of vitamin B-12.(177-179) It is the requisite form of vitamin B-12 in the methylation cycle.(179-186). Methylcobalamin protects cortical neurons against NMDA receptor-mediated glutamate cytotoxicity.(187-188) and promotes nerve cell regeneration.(189) Methylcobalamin is the only form of vitamin B-12 that participates in regulating circadian rhythms (sleep/wake cycles). It has been shown to support improved sleep quality and refreshment from sleep, as well as increased feeling of well-being, concentration and alertness.(190)
Adenosylcobalamin (dibencozide), another highly active form of vitamin B-12, is essential for energy metabolism(191) and is required for normal myelin sheath formation and nucleoprotein synthesis. Deficiencies are associated with nerve and spinal cord degeneration.(192-193)
Cyanocobalamin, the most common form of B-12 found in nutritional supplements, is a synthetic form of B-12 not found in nature. It has the lowest biological activity and must be converted in the liver to more biologically active forms. This conversion is inefficient and some people who may not benefit from cyanocobalamin due to lack of assimilation or conversion.(194-195) However, the cyano form of B-12 is needed to balance hydroxycobalamin in performing its NO-quenching function and should therefore be included in hydroxocobalamin supplements.(176)
Who is Vitamin B-12 Deficient and Why?
Research shows that a much larger segment of the general population is vitamin B-12 deficient than previously thought. Recent studies indicate that up to 78% of seniors are deficient. (196-197)
Irritable bowel syndrome (IBS), seen in as many as 77% of CFS patients and 78% of FM patients,(198-199) is a major cause of vitamin B-12 deficiency.(200) This leads one to ponder the "which came first, the chicken or egg" nature of this: Are ME/CFS patients B-12 deficient because of IBS, or is IBS a result of cellular or neurological insult caused by B-12 deficiency?
Other high-risk groups for B-12 deficiency include:
Bacterial overgrowth of the small intestine, which occurs frequently in people with ME/CFS and low stomach acid, is a predisposing factor for B-12 deficiency because the bacteria themselves use vitamin B-12. (208-209)
The most recent and disturbing studies suggest that vitamin B-12 deficiency is more prevalent in young adults than previously thought. (210-211). One study found that vitamin B-12 deficiency was similar in three age groups (26-49 years, 50-64 years, and 65 years and older), but that early symptoms were simply less apparent in the young. This study also found that those who did not take a vitamin B-12-containing supplement were twice as likely to be deficient as supplement users, regardless of age.(210)
Secondly, unlike other water-soluble vitamins, B-12 is stored in the liver, kidneys and other tissues. Deficiencies of B-12 often appear so slowly and subtly as to go unnoticed, and blood tests for vitamin B-12 levels miss early deficiency states at least 50% of the time.(212-213)
Why Many People Need to Obtain Vitamin B-12 From Supplements
Medical science once believed that few people were vitamin B-12 deficient. This false assumption may stem from the fact that vitamin B-12 is produced in the body by a normal, healthy population of bowel bacteria.
Foods are not a significant source of vitamin B-12 in most diets. Meat, milk, eggs, fish, and shellfish contain the highest amount of B-12, but only 50% of this is absorbable even in a healthy gut. (215) Vegetarian sources of vitamin B-12, such as algae, are not bio-available and do not make a significant contribution to dietary vitamin B-12 levels. (216)
Further, absorption is hampered by low stomach acid, IBS, and bacterial overgrowth of the small intestine - conditions which are common in ME/CFS sufferers. The US Institute of Medicine recommends that adults over 50 obtain vitamin B-12 from supplements. (14)
Oral vs. Injectable: Which is Best?
Although vitamin B-12 has previously been given by injection, it is now accepted in conventional medicine that oral & sublingual vitamin B-12 is equally as effective as injection in treating pernicious anemia and other B-12 deficient states. (214, 217-220)
According to The National Institutes of Health (NIH), oral vitamin B-12 supplementation is extremely safe(221-222). It is also as effective as injections,(14,219-220) and inexpensive and more convenient compared to injection.(220)
All Roads Lead To B-12: Conclusions and Recommendations
The suffering from ME/CFS and other multi-system diseases is widespread and devastating. This affliction is beginning to receive more attention, perhaps because of the activism of those affected and the dedication of ME/CFS researchers and clinicians. Current research is providing us with new insights into the underlying mechanisms of this complicated illness.
The Nitric Oxide/Peroxynitrite model (NO-/ONOO-) and The Methylation Cycle have emerged as two likely contributory mechanisms to ME/CFS and other multi-system diseases including Fibromyalgia, Lyme disease, Multiple Chemical Sensitivities, PTSD and Gulf War Syndrome. Deficiencies of either of two forms of vitamin B-12 - hydroxocobalamin and/or methylcobalamin - play a significant role in these biochemical processes.
Since vitamin B-12 (especially the hydroxocobalamin and methycobalamin forms) offer such potential benefits for ME/CFS and other multi-system disease sufferers - without known risks - it seems reasonable to suggest that anyone suffering with ME/CFS or other multi-system illness should consider taking a supplement containing these two important forms of vitamin B-12.
Furthermore, because of the balancing effect that cyanocobalamin has on hydroxycobalamin (176) and the protective and regenerative effect that adenosylcobalamin exerts on the myelin sheath of nerves (192-193), these forms should also be considered as an important part of any complete vitamin B-12 supplement.
* Dr. Dana Myatt, NMD, is a practicing naturopathic family physician, educator, author, and speaker with a special interest in nutrition. She lectures widely to medical and lay audiences, and hosts a website http://www.drmyattswellnessclub.com . Mark Ziemann, RN, Dr. Myatt's husband and collaborator, is also an educator, author, and speaker specializing in holistic nursing practice and patient education.
Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, treat or cure any condition, illness, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.


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Phyllis Diller, who died at age 95 Monday in her Los Angeles home, pioneered raucous, borderline rude and - dare we say it? - even liberated comedy in a way that left subsequent generations of funny females forever in her debt. From the archives: Phyllis Diller's final L.A. performance | Photos: Phyllis Diller | Video: Classic Diller performances
With her Medusa hair, garish makeup, hyena laugh and bottomless supply of one-liners that deflated the American domestic dream, the standup, author and actress was a pioneer in throwing decorum under the bus in pursuit of laughs.
"I'm beyond saddened by the death of Phyllis Diller," one of those comediennes and Diller pal, Joan Rivers, said in a press statement. "(Rivers' daughter) Melissa and I had a wonderful time with her at lunch just a month ago. The only tragedy is that she was the last from an era that insisted a woman had to look funny in order to be funny. If she had started today, Phyllis could have stood there in Dior and Harry Winston and become the major star that she was. I adored her."
While Rivers' appearance observation has merit, it could also be said that some comics who may not have been thought of as pretty enough for prime-time found their TV career paths smoothed by Diller.
"Phyllis Diller, thank you for what you did for all women in comedy who followed your path," tweeted "Laugh-In" regular Ruth Buzzi, one of dozens of comics who took to Twitter on news of her passing. "My dear friend, rest in peace; I'll miss you."
"We lost a comedy legend today," Ellen DeGeneres added on Twitter. "Phyllis Diller was the queen of the one-liners. She was a pioneer."
Born in Ohio, Diller was in her late 30s and raising five children when her first husband, Sherwood Diller, convinced her to try standup at a San Francisco club in 1955. Although the fictitious "Fang" - the spouse oft referred to in her act - was neither Mr. Diller nor the performer's second husband of a few months, Warde Donovan, it was always clear that marital dissatisfaction was a key source for her humor.
But Diller didn't dwell on angry woman cliches. She ribbed her own failings - as a homemaker and aging non-beauty, which later mutated into streams of jokes about her plastic surgery misadventures - at least as much as she did those of the male sex.
Despite a career primarily defined by live performances and talk show appearances, Diller headlined two network series in the 1960s ("The Pruitts of Southampton" sitcom and the variety showcase "The Beautiful Phyllis Diller Show"), made dozens and dozens of television guest star roles. She headlined a few movies, had a brief run on the soap opera "The Bold and the Beautiful," and lent her distinctive, cackling voice to a plethora of animated projects from the Pixar feature "A Bug's Life" to a recurring bit on the Fox series "Family Guy."
That show's creator, Seth MacFarlane, tweeted Monday "Let's all drink to the great Phyllis Diller," proving perhaps that women weren't the only people influenced by the comedienne's anarchic humor.
Not all Diller aficionados are in-your-face cut-ups, either.
"I adored her," a statement from Barbra Streisand read. "She was a wondrous spirit who was great to me."
You did not have to be in show business to be touched, and tickled, by Diller either.
"While I am deeply saddened by the loss of my friend Phyllis Diller, I can't help but smile," U.S. Rep. David Dreier, R-San Dimas, said. "On July 17th - her 95th birthday - she gave me her famous laugh when I reminded her of one of her vintage jokes. It went as follows: `I asked my husband, Fang, to take me out to dinner and he set up a card table in the garage.'
"Her kindness, sharp wit, and creativity meant a lot to me," Dreier added.
That's what her fans loved about her as well. But they, too, could appreciate her professional groundbreaking.
At Diller's last live L.A. performance, in April 2002 at Cal State Northridge, audience member Emma Weintraub told the Daily News: "She's really outstanding. She's opened the door for a lot of female comedians who wouldn't have gotten a chance without her."