text:
Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy (jPK)
Recruitment status was: Not yet recruiting
- Full Text View
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- Disclaimer
- How to Read a Study Record
|Obstructive Tonsillar Hypertrophy Tonsillitis
|Device: Plasmaknife Device: Monopolar
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
- pain
- return to normal activity
- return to normal diet
- medication dose taken
|Estimated Enrollment:
|Study Start Date:
|May 2007
This is a prospective, randomized controlled study to compare the efficacy of the Gyrus ACMI PlasmaKnife™ electrosurgical device used with the Gyrus ACMI Workstation versus monopolar electrosurgical device (i.e. Bovie®) for tonsillectomy.
The primary outcome will study the potential for reduced post-operative pain when the PlasmaKnife is used for tonsillectomy compared to a monopolar device. Secondary outcomes such as return to normal diet and activity as well as a range of complications including primary and secondary bleeding will be included in the study.
The study will involve approximately 100 patients at Children's Hospital of Michigan that meet the criteria for tonsillectomy (with or without adenoidectomy) for infected tonsils or airway obstruction.
The study will be documented through the use of Case Report Forms.
|Ages Eligible for Study:
|4 Years to 16 Years (Child)
|Sexes Eligible for Study:
Inclusion Criteria:
- Patient should be between the ages of 4 and 16 years old inclusive.
- Patient should meet criteria for tonsillectomy.
- Patient's guardian able and willing to complete patient diary and keep to the follow-up visit.
- Guardian able to understand English (written and oral).
Exclusion Criteria:
- Patient that has active medical implant(s) such as pacemaker, cochlear implant, etc.
- Patient has abnormal blood coagulation, history of easy bruising, bleeding disorders or uses anti-coagulants.
- Morbidly obese children (calculated BMI over 39)
- Patient that has history of malignancy or acute peritonsillar abscess
- Patient has Sickle Cell disease or is immunocompromised.
- Patient is pregnant or lactating.
- Active infection with fever greater than 101.5 degrees F.
- History of heart disease, diabetes or hypertension (with systolic blood pressure > 160 mmHg).
- Craniofacial anomaly.
- Biopsy of tonsil needed to rule out neoplasm.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00466544
|United States, Michigan
|Detroit Children's Hospital
|Not yet recruiting
|Detroit, Michigan, United States, 48201
|Contact: David Madgy 313-745-9048 email@example.com
|Contact: Mary Ross (313) 745-9050 email@example.com
|Principal Investigator: David Madgy
|Principal Investigator:
|David Madgy
|Detroit Children's Hospital
|ClinicalTrials.gov Identifier:
|NCT00466544 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 26, 2007
|Last Updated:
|April 26, 2007
Keywords provided by Children's Hospital of Michigan:
Chronic tonsillitis
Recurrent tonsillitis
Additional relevant MeSH terms:
Pathological Conditions, Anatomical
Pharyngeal Diseases
Stomatognathic Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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Tabletop Game Night
FHCPL will host Tabletop Game Night. Adults and teens are invited are invited to play gaming favorites like "Reverse Charades," "Apples to Apples", "Castellan", "Sushi Go!" and more. Parcipants are invited to bring their own games as well. The program is part of the generosity of game creators: Alderac Entertainment Group, Rio Grande Games, Gamewright, & Steve Jackson Games. No registration is necessary. For more information, call 419-422-1712.
Mon, 08/22/2016 - 6:00pm to 8:00pm

subset: commoncrawl


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Victory Multimedia BLAZE WHITE LIGHT 30 DEGREES (32WS2130)Item#: 9703107 | Model#: 32WS2130
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text:
Rivera meets, greets Tribe staffers, 'drummer'
CLEVELAND -- For each of his 19 seasons in the big leagues, Mariano Rivera has heard the rhythmic banging of John Adams' bass drum in the outfield seats, comprising the trusty soundtrack to accompany every game his Yankees have played within the Cleveland city limits.
On Wednesday, Rivera finally had the chance to shake Adams' hand and thank him for his passion. As part of his ongoing "Mo-ment of Thanks" tour, Rivera greeted a group of longtime Indians staffers at Progressive Field and even had his chance to give Adams' drum a light tap.
"It's a blessing. Wonderful," Rivera said. "I always said, 'Man, this guy is so loyal to the team.' Whatever happens, good or bad, he's there banging that drum. You appreciate that, the loyalty and faithfulness. That's what it is all about. It's not about what team he roots for, it's about baseball. He roots for his team, but it's baseball that is all around."
Adams, who has been banging his drum at Indians games since 1973, said that he appreciated the opportunity to meet with Rivera.
"It's a stress relief for me -- and you've given me a lot of stress!" Adams told the Yankees closer.
Yankees director of media relations Jason Zillo said that Rivera first floated the idea of doing something different with his farewell season a few years ago. Rivera toyed with the idea of retiring last year, but never made it official; with the announcement that he'll retire at the conclusion of the 2013 season, Rivera now wants to take the time to give something back in each city the Yankees visit this season.
"This is what it is. You want to be able to say thanks to these people," Rivera said. "No one sees these people. You take the time to say thanks. When I retired, I wanted to do something different, something that people don't see. It doesn't always have to be the same [ceremony] on the field. There's a lot of other people that run the teams. They are here, but we don't see them."
Rivera posed for photographs in the Indians' press conference room and signed autographs for each of the guests in attendance, but his favorite part was interacting with the people; Rivera shook hands and listened intently to each personal story of service to the game and also fielded questions in a wide-ranging Q&A.
One person asked Rivera what his least favorite memory of pitching against the Indians was, and while the expected answer would be Sandy Alomar Jr.'s home run in the 1997 American League Division Series, Rivera offered a slightly different take on that crushing defeat than his Yankees teammates had at the time.
"Let me tell you something about it," Rivera said. "If you think that '97 was bad, I'd tell you for me, it was the stone where I stepped to push forward. It helped me to become better. If that wouldn't have happened, God only knows where I would have wound up.
"Because that happened, it pushed me to be better in moments like that and situations like that. I have to appreciate that event and that moment, and all the years, it's been a battle here. I never will say that it was easy."
Bryan Hoch is a reporter for MLB.com. Follow him on Twitter @bryanhoch and read his MLBlog, Bombers Beat. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Which Bottle?Logic puzzles require you to think. You will have to be logical in your reasoning.
You are stuck in a room. All that is there is a slip of paper on a table, and many bottles. The only exit is guarded by a heat sensor that will not let you out. The only way out is to drink one of the bottles' contents, and the liquid will cool down your body heat (with no harm to yourself) enough so that the heat sensor doesn't detect you anymore. There are nine bottles on the ground beyond the table. The content of the slip of paper will tell you what each of the bottles are. Find out what all the bottles are, and then find out which one to drink to get out.
Three of me are poison, and will kill you if you drink.
Two of me are water, nothing bad will happen with these.
Two of me are wine, and it will only get you drunk.
One will heat you up forever, and this room will never let you out. (hinder)
Only one here will help you, it will cool down your body heat.
No medium bottles are poison.
Wine is bad in large doses, so none are large.
Each of the end bottles have the same contents.
No matter how help hides, it will be on poison's left side, but its left side is safe.
No two small bottles are the same.
The hinderer is harder, for it resides between wine and water.
The hinder bottle is large, so it works forever.
Neither big nor medium will save your life.
Poison is all you will get from the bottle on the far right.
Water is next to the helper.
Bottle Order:
Only the middle bottle will save your life.
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text:
The Detroit Tigers are under fire for seemingly innocent Facebook photos in which stars like Miguel Cabrera and Justin Verlander posed with their team's namesake.
The International Fund for Animal Welfare issued a statement Monday decrying the team for posing with tiger cubs from the Dade City Wild Things Zoo.
The photos were taken last week during spring training and posted Friday (March 29) to the Tigers' Facebook page.
The IFAW attempts to shame the Tigers for ignoring the possible "fairly significant public safety and animal welfare issues."
"Handling a wild big cat is not a game and treating them like a 'pet' poses extreme risks," the statement reads.
The animal rights organization sites recent tragedies involving captive big cats -- which it defines as lions, cougars, leopards, jaguars, and cheetahs, among other species -- saying incidents have resulted in 22 human deaths "nearly 300 human injuries" in the past two decades.
A Detroit Tigers representative said the tiger cubs' appearance was part of a fundraiser at Joker Marchant Stadium, the Tigers' springtime home, for the cubs, whose home was destroyed by a tornado that hit the Dade City Zoo March 24.
The heart-warming story was omitted from the Facebook post.
Fans were quick to voice their displeasure to the post. The photos got more than 20,000 likes, 5,377 shares and more than 1,100 comments, many of which criticizing the animals' use.
The comments on the Dade City's zoo's Facebok page were much more favorable.
The IFAW alleges traveling zoos, like the one used by the Detroit Tigers, turn a profit showing off the child animals, which are disregarded -- even killed -- after outgrowing their usefulness to the entertainer.
In closing, the IFAW asks the Detroit Tigers to leverage their audience "to use their mascot and national voice to educate people about the dangers of big cat ownership and pledge that they will, in the future, choose not to pose with tiger cubs because they would never knowingly want to support an industry that thrives off the exploitation of this species."
The Tigers opened the regular season Monday afternoon in Minnesota.


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During a recent National Sales Meeting, colleagues in Pfizer Animal Health's U.S. Cattle and Equine Business Unit decided to forgo some food and beverages throughout the week and instead donate the money saved to Bethel Orphanage in Juarez, Mexico. The $11,000 donation from Pfizer Animal Health represents about 6 percent of the orphanage's annual operating budget.
"We are honored to support Bethel Orphanage, which plays such an important role in serving abused and abandoned children in Juarez," says Rob Kelly, vice president, U.S. Cattle and Equine Business Unit, Pfizer Animal Health. "We especially appreciate the staff's focus on education. In fact, some of its former residents have gone on to successful careers as engineers and veterinarians."
Ruben Lopez is one such success story. Lopez's mother took him and his brother to Bethel Orphanage when they were 7 and 6 years old, respectively, to protect them from an alcoholic stepfather. "My mother didn't go to school and was unable to provide for us. She asked for help, and the orphanage gave us food and a home and encouraged us to study," explains Lopez. "When my mother left us at Bethel Orphanage, she said a part of her heart was staying there with us."
Lopez lived at Bethel Orphanage until he graduated from high school and went to the University of Juarez, where he is studying to become a veterinarian. He has spent the last four summers working at Eldorado Dairy in Clovis, N.M. "Helping with breeding and reproduction is my favorite part about working at Eldorado," Lopez says. "I hope to work in the United States after I graduate and I also am thinking about studying for a master's degree in reproduction."
Lopez says he learned about the many opportunities in veterinary medicine from Carlton Flatow, Pfizer Animal Health strategic account manager who has been involved with Bethel Orphanage for many years.
"I have been really impressed with the founder of Bethel Orphanage, who has been responsible for these children for 30 years. Local resources are very limited, so she relies on the generosity of others to break the cycle of poverty, violence and lack of education," says Flatow. "I'm proud of my Pfizer Animal Health colleagues for supporting this effort to provide the basic necessities and education for so many underprivileged children like Ruben. A little goes a long way in Mexico, and it's very rewarding to help improve the lives of so many."
By reducing the amount of food and beverages served during the conference, Pfizer Animal Health saved $11,000 and earmarked the money for the approximately 100 children who live at Bethel Orphanage. The donation will provide nearly four months' worth of food for about half of those children.
Lopez hopes to serve as an inspiration for those young children. He explains, "I love going back to Bethel Orphanage. Telling the kids where my brother and I came from, and explaining how I'm studying to be a veterinarian and my brother is studying to be a civil engineer is fun."
The Pfizer Animal Health donation was sent to Faith Christian Family Church in Lubbock, Texas, which ensures all donations are delivered to Bethel Orphanage.


text:
Channing Tatum at London Premiere of G.I. Joe Retaliation
Channing Tatum Joins His G.I. Joe Costars For a Rainy Red Carpet
Channing Tatum joined Dwayne Johnson, Adrianne Palicki, and more of his G.I. Joe Retaliation costars for the film's London premiere today. He dressed up in a suit to debut the film in the UK ahead of its March 27 release overseas. Channing has special ties to the city since he and pregnant wife Jenna Dewan announced that their first child will be born in London while he is on location shooting his next project.
Along with his latest film, he's also promoting the upcoming MTV Movie Awards. Channing stars in a new promo video with Rebel Wilson that was released last week. It could be a big night for the star since he's nominated for three awards for Magic Mike, including best male performance, best shirtless performance, and best musical moment, at the April 14 show.


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I was under the impression that was why BIRD drafted Plumlee. Otherwise, why draft him?
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I was under the impression that was why BIRD drafted Plumlee. Otherwise, why draft him?
OK, what is your point? Yeah obviously it would have been better to get him at $6 million, everyone knows that without you going on and on about it.
$2 million is the difference between not needing to have a great season, and needing to have a super season? At that standard only LeBron consistently lives up to his contract.
If you have some information from a credible source that says we didn't try to get him for cheaper than by all means present it. If all you are doing is speculating because you personally don't think he is worth $8 million, please stop talking about how we didn't try to get him for less.
You are right. I forgot about Miles
Shame on me
That doesn't have to make me happy with the end results!
I said when it came to light that there was a chance Walsh would be replacing Bird I felt it was a grave mistake. I still do!
I also stated if Walsh took over my interest in the Pacers would wain. AND unfortunately IT HAS! This comes from a Pacers fan who was there for the telethon to keep the Pacers afloat.
That just makes me sad
NO, I have no info, but then neither do you or others to the contrary, now do you? I have opinions the same as you. If my posts aren't to your liking and you deem them repetitive, might I suggest you put me on ignore, so you won't have to read my repetitive views. Please have a nice day.
No, but I am not making accusations either. That is the difference. I am not going around acting like I have some kind of idea of how it went down. All I know is that we signed Hill for a flat $8 million a year(not abnormal for a starter of his quality), and so far he has lived up to his contract. That is all I know. You might think he hasn't, and you have the right to that opinion, I am not arguing against your opinion, that doesn't mean it is ok to go around making accusations about how the front office should have done it when you have no idea how it actually happened. You are just creating baseless rumors.
While the Pacers may be over paying George Hill , his contract does not increase each season which is a plus.
Thats the key reason why Roy Hibbert's contract is the Pacers bad contract. Unlike Hill's , Hibbert's contract goes higher and higher each season. He was rewarded with a new contract with a 1st year raise in excess of 10 million dollar , with future increses to 14.3, 14.9 and 15.5 mil a season.
While George Hill has increased his productivity , thru a 5th of the season Roy has become an even more inconsistant player than at any time since his rookie season. People talk oh he just posted a triple double - yes he did his 11 rebounds were in large part to his own lousy shooting 3 of13 fga. His fg% has dropped from almost 50% to less than 39% even in his worse seasons JO on too many fade aways shot better. His ft% from 71% to 53% . Do you think the Blazers are wishing Walsh didn't resign Roy at the moment? More likely they sent him a Christmas card with a huge thank you .
The one plus is with looser calling of fouls he has increased his blocks per game from 2 to 3. Roy is a great guy but he has come no where near earning his money , not even earning what he was paid last season. At least in Hill's case you make a strong case he has been clutch late in games.
Last edited by diamonddave00; 11-30-2012 at 03:55 PM.
I really don't see all the need for argument concerning how the Pacers and Hill arrived at 8M per year.
First off, it's not like the Pacers started with a 20M per year offer and worked there way DOWN to 8M per year. Duh. Isn't it far more likely that the Pacers, not wanting to be too confrontational, started at some offer and worked their way UP to 8M per year? Of course it is.
I doubt this negotiation was very formal in nature at all. I'm sure a lot of it was verbal until the Pacers either offered a number or agreed to a number that both parties could easily sign off on. Again, I think that they wanted the negotiations to remain amicable and did not want to risk confrontation at all. It was probably a pretty simple negotiation for both sides.
Does it really matter how they got there? The fact is, that they are at 8M per year. Whether you think that is too much is a different story.
Ist let me say in the 4 years I've been associated with PD you are one of my favorite posters. I might add I wish you posted more!
Now to your post which has merit. I have neogiated business deals most of my life, and I absolutely can't stand to leave money on the table b/c of poor neogoiating. My main issue is that Walsh was bidding against himself, since Hill's agent never tendered an offer sheet. People can say other teams had interest in Hill all day long, but there was never an offer sheet. An offer sheet says someone is truly interested and not just speculation that other teams were interested. W/o an offer sheet Walsh was bidding against himself. This just grinds my gears.
Yes, I feel Hill is overpaid. IF the Pacers could have saved 2 mil on Hill it was 2 mil more Walsh could have spent on better upgrading the bench. The same can be said concerning Hibbert's overpaid contract.
I fully realize BIG men get paid more, and that Hibbert would get paid well. But why overpay? After Portland pulled out of the bidding, who was left that had the money and need? Both J McGee and D Jordan signed contracts that pay them 10 mil this year. Jordan is averaging 10/7 per game and McGee is 10/6. Personally, I feel they both are overpaid for those numbers. Where as DWest is an absolute bargain this year at 10 mil!
I will admit some of my being upset with what I feel are overpaid contracts and poor contracts is, b/c I NEVER wanted Walsh back. I had NO confidence in Walsh being able to do the job properly. So far he's justified my belief. Walsh was the reason Chris Mullins got Exec of the Year for pawning Dunleavy and Murphy's albatross contracts off on the Pacers. I really wish I didn't feel as harshly about Walsh as I do, but he's done nothing to change my mind about him.
I will end by saying I hope both Hill and Hibbert's play justify their contracts. I never mind having to say I'm wrong or having to eat crow when I'm wrong.
But Portland pulled out because the Pacers announced they would match the offer. Is it your position that once Portland pulled out the Pacers should have said, "Ha ha fooled you here's a non-matching offer"?
That seems wrong on so many levels as well as meaning Portland could have just gone ahead and come right back with their offer sheet.
A bird in the hand is worth two in the bush.
Or throw in a first-round pick and flip it for a max-level point guard...
Once Portland re-signed Batum they couldn't make another offer sheet to Hibbert. Pacers in drivers seat. BB is 1st and foremost a business. It's not a business for the faint of heart. Was there ever anything concrete from the Pacers to Hibbert saying they would match Portland's offer?
Hibbert and agent knew the Pacers were going to sign Hibbert to a contract. The point is the Pacers were in the drivers seat once Portland backed out. Walsh was bidding against himself again.
I have to give Walsh credit when credit is due, he only gave Hibbert a 4 year contract instead of a 5 year contract. The contract is bad enough now, but a 5 year contract would have been an absolute financial disaster for the Pacers for years to come.
You can't do this. Once you promise to match an offer sheet there's no taking it back, unless you never want to sign another free agent again.
That's a good point as well.
Who was the player that agreed to re-sign with Cleveland then signed with Utah for more money? Just the opposite I know, but no team after that refused to sign him over doing it. Verbal agreements aren't worth the paper they are written on.(Yogi Berra?)
Didn't Portland rescind Hibbert's offer sheet? Isn't that a sign of bad faith and business? They made the offer 1st, so shouldn't they have to stick with their offer sheet?
Let's face it, in the business world companies rescind offers on deals all the time. I wouldn't be surprised if Herb Simon's company hasn't done that exact thing.
No, they didn't. They offered it, Indiana told Roy they were matching, so Roy never signed it.
Now, I think someone reported that the deal was rescinded after Indiana matched...which basically means nothing.
The Pacers called Hibbert to tell them they were going to match. They almost certainly didn't put it in writing because they needed Hibbert to wait to sign his contract to use the extra cap space. If they put an intention to sign him to a contract in writing, they would have risked running afoul of the NBA's rule about abusing the cap.
Portland still had money to spend after Batum signed. They just didn't have the potential to offer the max anymore. IIRC, they were only a couple of million off from being able to afford both. Dallas to name another example also had cap space available after missing out on Williams. Plus, Hibbert's an emotional guy. If the Pacers suddenly pulled the rug out from him and withdrew the offer after promising him they would match, don't you think Hibbert likely bolts for one of those teams even if it ends up being slightly less money?
I never liked the fact Hibbert was bolting the Pacers for Portland for more money in the 1st place. The Pacers drafted him and invested 4 years in him to only be slapped in the face b/c Hibbert wanted the BIG BUCKS and didn't care who paid them. This is a reason after Portland was out of the picture I'd never have matched Portland's offer. He'd have signed somewhere in the D Jordan and J McGee money range. If he was unhappy with the offer, S&T his rear to another team.
As far as Dallas goes, I don't see Cuban spending the money this past off season. I'm sure Portland and whoever else aren't sad they didn't sign Mr. Fragibility to the contract Hibbert got from the Pacers. Portland's FO has to be smiling over their loss of Hibbert.
That was Boozer.
"It's just unfortunate that we've been penalized so much this year and nothing has happened to the Pistons, the Palace or the city of Detroit," he said. "It's almost like it's always our fault. The league knows it. They should be ashamed of themselves to let the security be as lax as it is around here."
----------------- Reggie Miller
Portland did not rescind their offer. They had every intention of making the max offer. In fact, Hibbert was preparing to go to Portland to sign the sheet, when he was told that he'd be signing the same deal with the Pacers. The Pacers interceded and agreed to sign Hibbert to the same terms offered by Portland. Then, as a courtesy, the Pacers and Hibbert's agent notified Portland, so they would not have to go through the exercise of the offer sheet and the cap hold associated with it.
It was also reported that one other team offered Hibbert a max contract.
Roy Hibbert was getting a max deal last summer - be it from the Pacers or another team.In addition, the source said one other team, which was not named, also offered Hibbert a max deal after the start of free agency on Sunday at 12:01 a.m. ET.
Read More: http://sportsillustrated.cnn.com/201...#ixzz2DqBsrGIE
...Originally Posted by Justin Tyme
This may be the worst post I have ever seen on PD. If you think you can build a team by making bad faith moves like you describe try it and see how it works. Stars don't want to come here now but if they follow your suggestions, no player would want to come to the Pacers. Hibbert was a free agent and he had every right to sign with Portland or any other team that would pay him the most money. He didn't owe the Pacers a damn thing. That is what free agency is all about.
Just like within any profession, professional athletes have the right to maximize how much money they are to be paid. If a team wants to offer him big money, why does he need to turn it down? Because the Pacers drafted and developed him? Unfortunately, that's NOT how it works. Yes the Pacers drafted and developed him, but that's the organizations job--to draft good players and put them in the best possible position to develop and succeed. Had the Pacers not drafted him, another team would have, and would have done the same thing--did everything they could top help him succeed.
You can argue that the Pacers could have went another route as opposed to re-signing Hibbert for a big money contract, but don't get angry at Roy because he maximized his earnings. He didn't MAKE the Pacers pay him. We made that decision as an organization. That's not on Roy.
I liked what Jerry Reynolds said about Hibbert during the Kings' broadcast last night. "He's still 7'2", he hasn't shrunk and the FG% will come around."
If there was something Donnie did that I didn't like -- I don't like the Gerald Greene contract - its too much like Dhantay Jones' that we finally got rid of. It will be bad news next summer if we have difficulty resigning West because we could use another million or two from the Greene contract.
Paying Hibbert, a legit 7'2" C that type of money to be our second or third option seems like the right math and economics to me.
Paying $18 million this year to West and Hill to be our two go-to guys in the fourth quarter is pretty good cap management, IMO.
Why do the things that we treasure most, slip away in time
Till to the music we grow deaf, to God's beauty blind
Why do the things that connect us slowly pull us apart?
Till we fall away in our own darkness, a stranger to our own hearts
And life itself, rushing over me
Life itself, the wind in black elms,
Life itself in your heart and in your eyes, I can't make it without you


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LUTA: A Brand with a Genuine Social Mission
October 11, 2012
LUTA is a sports performance and lifestyle clothing brand that brings together real fight performance, favela street style, and a genuine social mission. Profits from its clothing sales go to Fight for Peace, an international non-profit organization based in Rio de Janeiro that helps young people realize their potential in communities that suffer from crime and violence. Luke Dowdney MBE, Chief Executive Officer & Founder, LUTA, spoke about his vision for the brand and what the future holds for Fight for Peace.
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Colonial Marines and the mother of all Aliens getting the NECA treatment soon...
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, RedfordFilms.com, PastGenerationToys.com, BriansToys.com, ToyWiz.com, SmallJoes.com, MonkeyDepot.com, and Urban-Collector.com.
The Aliens movie license will see various releases in the coming future including two Colonial Marines of which one character has been confirmed to be Corporal Hicks while the other will be announced at a later date. A brand new Alien Warrior with all new articulation is also in the works. Last but not least, the Alien Queen will be receiving the action figure treatment as well with a possible (not locked in) 2013 release.
While this is very exciting news for Alien fans, the biggest announcement is that NECA will be producing action figures based on the upcoming Prometheus film as a separate toy line. While no details regarding the figures could be divulged at press time, there is sure to be some fantastic content in Ridley Scott's upcoming Alien prequel.


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Riding High
Wait Two Years for a New Harley-Davidson? That's How Long It Can Take to Get Delivery on America's Motorcycle Wait Two Years for a New Harley-Davidson? That's How Long It Can Take to Get Delivery on America's Motorcycle
(continued from page 4)
Outside, the autumn dawn has broken clear and cool. You stand for a moment in the garage, contemplating the Heritage Softail Classic as though it were a postmodernist sculpture. Its gleaming chrome "big twin" 1340 cc engine and pipes, polished red-on-black fenders and gas tank, studded leather seat and saddlebags, extended bars and seven-inch headlight are the apex of form and function. It is as near perfect as any machine can be, and American-made.
Mounting the bike, you hit the starter button, and that distinctive Harley thunder fills the neighborhood. Without hesitation, you kick it into gear and you're off, heading for the open road, leaving the suburbs and city streets behind. Out on the highway, the pavement rushing past at a solid 65 mph, you feel the tensions of the week slip away. The backslapping and glad-handing, telephone screaming, busted deals, office politics, near misses, petty triumphs, life-and-death decisions, court theatrics, buys and sells...all gone, blown away by the power of the moment. You're in hog heaven, easy riding, and it's all yours: the machine, the highway, the distant hills.
* * *
If there is a company that symbolizes the rise, fall and resurrection of American industrial might, it is Harley-Davidson, Inc. From its humble turn-of-the-century beginnings in a Milwaukee garage, through a post-Second World War high, a 1970s low and a 1980s death bout with Japanese knockoff artists, Harley has roared on, becoming in the 1990s what may be the best-run manufacturing company in the United States.
The proof is in the product. The 20 models in Harley's 1995 motorcycle catalogue range from the basic XLH Sportster 883 ($4,995) to the posh FLHTC I Ultra Classic Electra Glide Thirtieth Anniversary Edition ($17,500). All Harley bikes have the look and feel of premium, heavyweight motorcycles, and with their abundance of chrome, state-of-the-art paint jobs and sleekly engineered features, they are--quite literally--beautiful machines. First-time visitors to a Harley-Davidson showroom often realize one of the great truths of the motor-vehicle age: to see a Harley is to want to drive one, to drive a Harley is to want to own one. As actor Mickey Rourke, a longtime Harley fan, has said about his Harley passion, "it's a personal thing that can't be described. It's part of you."
Much of the Harley's lasting appeal comes from an if-it-ain't-broke-don't-fix-it philosophy in style and design. Though mechanically the motorcycles have undergone a major reengineering in recent years, all models still incorporate styling elements that date back to the 1930s. The current guardian of the Harley look is William G. Davidson, vice president of styling, the last descendant of the company's founders to hold a senior management position. Willie G., as he is known throughout the motorcycle industry, studied design and worked at Ford Motor Company before coming to Harley in 1969 at the invitation of his father, William H. Davidson. He was given the task of setting up and managing the company's first styling department. From the beginning he showed a genius for understanding what the Harley customer wants.
One of Willie G.'s first projects was to alter Harley's superheavyweight Electra Glide model (much as California motorcycle customizers were doing at that time) to create the Super Glide. The transformation included removing the Electra Glide's windshield and saddlebags and replacing the massive front forks with lighter, longer ones. When it was introduced in 1971, the Super Glide proved that new models could be created without massive retooling and that production and profits could be boosted by moving customizing in-house. The Low Rider, Wide Glide, Fat Bob and Softail quickly followed, all created by simple design alterations and all of which still enjoy strong sales.
Harley's 1995 catalogue is a study in variations on a few basic themes: there are four Sportster models, four Dynas, six Softails (including the Bad Boy and the Fat Boy) and six Electra Glides (including the Road King). As Willie G. notes, despite a flamboyant image, most Harley customers are conservative when it comes to motorcycle design. "They rank the Harley look right up there with motherhood and God, and they don't want us to screw around with it," says Willie G. "They know what they want on their bikes, the kind of instrumentation, the style of the bars, the cosmetics of the engine, the look of the exhaust pipes and so on. Every little piece on a motorcycle is exposed, and it has to look just right. It's almost like being in the fashion industry."
* * *
York, Pennsylvania. Inside the 1 million-square-foot Harley-Davidson assembly plant on a cold November morning, workers are busy turning out the first of that day's 395 finished bikes. To a visitor on a private tour, it all seems deceptively smooth. The raw materials come in at one end of the plant, the completed motorcycles go out at the other. Between its Milwaukee engine and transmission plants and its York facilities, Harley produces more than 50 percent of the parts needed to make its products. The majority of the rest are also made in the United States.
"Ours is an American product, period," explains Harley-Davidson's CEO Richard Teerlink. "We go offshore for a part for only one of two reasons: either that part is simply not available domestically or what is available does not meet our quality standards. Price is not an issue. We will pay a premium for a U.S.-made part."
At the York plant, stamping machines take sheets of metal and turn them into fenders and other parts. Precision-welding robots close seamless joints. Despite the automation, much of the work is still done by hand; tinkers tap out metal parts to form precise curves, grinders smooth the curves into almost perfectly flat surfaces. Raw components disappear into the adjacent state-of-the-art paint shop and return via a conveyor belt, shining in one or more of Harley's distinctive colors. At another station, workers assemble hubs and spokes into finished wheels. The pace is steady but deliberately unhurried. This is especially true on the main assembly lines, where workers take their time adding components, testing torques, gauging tolerances.
"For us, quality is key," says Lynn Sweet, communications manager at the York plant and tour guide for the day. "Anyone on the line can stop production at any time. If there's a problem with a part, or if there's a parts shortage, it doesn't get passed on to be dealt with later. Production comes to a halt, and the problem is fixed."
One of the most striking things about the Harley assembly plant is the sense of order that prevails there. Some 2,100 people work three shifts producing parts and finished bikes. Yet everything seems to be stacked neatly in its place. There are no stray components, no debris, no trash. On this day only one assembly line, the 1340 "big twin" line, is operating, turning out the heavy machines that comprise four-fifths of Harley's models. As the shiny, new motorcycles roll off the end of the line, they are given a vigorous testing: starter, engine performance, emissions, brakes, lights, turn signals, horn, steering...you name it, it's tested.
In a small building behind the main plant, the final steps in quality control take place. Here, the half-dozen members of the company's Quality Audit Team carefully inspect a randomly selected portion of the finished bikes, measuring assembly, function and performance against a set of standards. "If we detect a problem that relates to parts quality or assembly, we get back to the line and either see that it is resolved immediately or shut down operations until it can be solved," says supervisor Ron Alexander. "In the old days, you'd have caught hell for doing something like that; now we'd catch hell for not doing it."
* * *
At Harley-Davidson, the "old days" go all the way back to 1901, when William S. Harley and Arthur and Walter Davidson set out to design and make a motorized bicycle. By 1903, the young men from Milwaukee, all barely in their 20s, had formed the Harley-Davidson Motor Company and turned out their first motorcycle, a 25-cubic-inch motor on top of a bicycle-like frame that had a top speed of 25 mph. In 1908, a new model powered by a 35-cubic-inch engine with a top speed of 40 mph was created. Harley-Davidson's total production for that year was just two bikes. But by 1908, the company was pumping out 450 motorcycles a year. The workforce had expanded from four partners and one employee in 1905 to 35 employees by 1909, according to Harley-Davidson archivist Marty Rosenbloom.
In 1909, Bill Harley designed the first of the company's distinctive V-twin engines. The V-twin, with a displacement of 49.5 cubic inches, a seven-horsepower kick and a top speed of nearly 60 mph, became the prototype of all Harley-Davidson engines to follow. By 1920, just 11 years after the V-twin made its debut, Harley-Davidson had become the largest motorcycle manufacturer in the world, producing more than 25,000 motorcycles and 16,000 sidecars a year, with 2,000 dealerships in 67 countries.
Despite the nearly fatal blow of the Great Depression (between 1929 and 1933 sales dropped by more than 80 percent), the company managed to sputter along until the Second World War, when military contracts helped boost sales back to early-1920s levels. The postwar slump hit rival Indian Motorcycle Company harder than it did the Milwaukee company, and in 1953 Indian closed its plant doors for the last time, leaving Harley-Davidson as the only major U.S. motorcycle manufacturer. By the early 1960s, Harley virtually owned the U.S. heavyweight motorcycle market, with sales soaring from about 10,000 units in 1961 to more than 30,000 in 1966.
Like many companies in the 1960s, Harley-Davidson made a disastrous mistake: it failed to take the Japanese threat seriously. While Harley rested on its laurels, the big four Japanese motorcycle companies (Honda, Yamaha, Kawasaki and Suzuki) were having a major impact on the U.S. lightweight bike market, and by the late 1960s, all were jealously eyeing the heavyweight segment. By then, consumers were beginning to view Harley's machines as outdated, oil-leaking heaps that stood in poor contrast to the sleeker, high-tech, oil-tight Japanese bikes.
In 1969, faced with an urgent need to upgrade production, capitalize expansion plans and prevent a hostile takeover bid, William H. Davidson urged company stockholders to accept an offer from American Machine & Foundry to buy Harley-Davidson outright for $22 million. The deal ended more than 60 years of family control of the company.
Though Harley had an enthusiastic friend in AMF's CEO Rodney Gott, the marriage got off to a bad start and never really improved. Gott's strategy for Harley was to expand production rapidly, something the motorcycle maker was ill equipped to do. Between 1969 and 1972, total output zoomed from about 27,000 to 60,000 units a year. At the same time, quality control went out the window. Bikes were rolling off the line with wrong parts, rusty parts and sometimes not enough parts.
To be fair, under Gott's direction, AMF pumped millions of dollars into research and development at Harley, including a $10 million new engine-development project (which was eventually shelved). But in the meantime, the manufacturing side of the business was a shambles. The Harley hog continued to leak oil, and the company to lose customers to the Japanese. By 1980, Harley's once whopping 78 percent share of the U.S. motorcycle market had dwindled to 30 percent, only slightly ahead of Honda.
"In the late '70s, Harley quality was horrible," says Mike Lombardi, third-generation owner of the F. Lombardi & Sons Harley-Davidson dealership in Staten Island, New York. "We didn't know if a bike was going to make it out of the showroom and down the street without us having to go after it with a pickup truck to collect the pieces." Harley CEO Teerlink agrees that "there was a perceived quality problem in the marketplace. The fact is, the Japanese were doing it better for less."
In February 1981, a group of 13 Harley-Davidson executives signed a letter of intent to purchase the company from American Machine & Foundry. By then, Rodney Gott, who had become a self-proclaimed "Harley freak," had retired, and AMF had lost its enthusiasm for the motorcycle trade. The deal was engineered by Vaughn Beals, an AMF executive sent to Milwaukee to reorganize Harley in the mid-1970s and the current chairman of the company's board of directors.
Beals structured a leveraged buyout requiring only $1 million in cash and about $80 million in loans (Harley was valued at about $300 million at the time). Financing was easily arranged through a consortium of eager banks led by Citicorp. As one Citicorp executive later observed, "what hit me was that this was the only product I'd ever seen that people had tattooed on their bodies."
* * *
Jeff Bleustein's favorite story about Harley's drive to regain its reputation as a manufacturer of high-quality motorcycles has to do with his wife, Brenda. Bleustein, now president and chief operating officer of Harley-Davidson's motorcycle division, was vice president of engineering during the AMF years. When he first moved to Milwaukee and bought a house, Bleustein came home one afternoon with a new bike and parked it in the garage. The next morning, there was a big puddle of oil under the bike. Bleustein says his wife told him, "I know you want to ride a motorcycle, but you'd better fix those oil leaks because there will be no motorcycles in our garage until you do."
One measure of the success enjoyed by Harley since the Beals-led leveraged buyout is that its engines no longer leak oil. In fact, the V-2 Evolution motor, designed by Bleustein's engineering team and introduced in 1983, is so precisely engineered that he can park a bike in his living room without fear of ruining the carpets.
"From the beginning, we decided that our emphasis was going to shift from volume to quality," says Teerlink, who joined the company as chief financial officer in 1981. "We took a hard look at the Japanese motorcycle industry, and we realized that their success had nothing to do with culture. They were just better managers than we were."
In an attempt to beat them at their own game, Harley's new owners introduced three standard Japanese manufacturing techniques: full employee involvement in problem solving and quality control; just-in-time inventory to lower the cost of holding large inventories of parts and have greater control of parts quality; and operator control, which calls for giving all workers the statistical training necessary to be able to measure the quality of their own output.
"None of these concepts are revolutionary," admits Teerlink. "The problem has always been one of implementation. We were in a fight for our lives, and once people began to realize that and to understand that we didn't want them to come to work and check their brains at the door anymore, things began to click."
In 1982, arguing that Honda and Yamaha had amassed huge inventories that they intended to dump on the U.S. market, Harley-Davidson petitioned the International Trade Commission for tariff protection. A similar request had been turned down by the Carter administration in 1978. This time, the ITC responded positively, and in April 1983, the Reagan administration imposed stiff tariffs on imported motorcycles with engines of 700 cc's or greater for a limited five-year period.
"It was really a symbolic gesture, since Honda's and Kawasaki's U.S.-assembled bikes were exempt from the tariff, and Yamaha and Suzuki shortly came out with motorcycles that were slightly less than 700 cc," says Teerlink. "But it did send a message that the United States was not going to let its motorcycle industry die by the side of the road."
By 1987, in an unprecedented move, Harley's new masters were confident enough to petition the ITC again--this time to ask that the 1983 tariffs be lifted a year ahead of schedule. "It might seem like a strange thing to do," admits Teerlink. "But it really gets down to values. We'd upgraded and refined our designs, revamped the entire production process, and sales and customer satisfaction were high. We just didn't believe it was right to continue operating in a protected market because we'd accomplished what we'd set out to do."
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The WelcomeThe occasional musings of one "Severin", a misunderstood and most goodly boy. But BE WARNED, I sometimes write about naughty things, so this blog is NSFW and only suitable for over 18s. So whether you're here by accident, or because you've stalked me, welcome. Feel free to browse, comment, follow, subscribe or generally abuse.
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One partly-used Severin for hire
Now, as it happens, I am currently looking for a change in direction. A new challenge if you will. And as I've been looking around at various possibilities, it occurs to me that I should also try asking the very … Continue reading
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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Bush, MD, FACC, FSCAI
Professor of Cardiovascular Medicine
Director of Health Sciences Administration
Division of Cardiovascular Medicine
Department of Internal Medicine
College of Medicine
The Ohio State University
Dr. Charles Bush is Medical Director of the OSU Richard M. Ross Heart Hospital. He is professor of Internal Medicine in the Division of Cardiovascular Medicine and previous director of the Cardiac Catheterization Lab at The Ohio State University Medical Center. Dr. Bush is a long-time leader at OSU, having served as chief of staff in the 1990s and director of the cardiac catheterization labs for 26 years. A world-class expert in the field of cardiovascular care, Dr. Bush has authored more than 100 articles, abstracts and books/chapters and served on the editorial boards of several peer-reviewed publications, including Annals of Internal Medicine, Journal of the American College of Cardiology and Catheterization and Cardiovascular Diagnosis. Dr. Bush's research interests range from percutaneous transluminal coronary angioplasty to thrombolytic therapies. He is a veteran of the U.S. Air Force and a Fellow of the American College of Cardiology, American College of Physicians and Society of Cardiac Angiography Intervention.
Dr. Bush has been practicing medicine nearly 40 years, in continuous affiliation with OSU Medical Center. He is a U.S. Air Force veteran, having attained the rank of Captain.
Case Western Reserve University, Cleveland, Oh
Residency in medicine, The Ohio State University; Fellowship in cardiology, The Ohio State University College of Medicine and Public Health
Clinical Interests
Cardiovascular disease, coronary artery disease, interventional cardiology
Research Interests
Interventional cardiology, pericarditis, PTCA, thrombolytic therapy, coronary artery disease
• Charles F. Wooley, MD, Transmission of Excellence Teaching Award
• Professor of the Year Award
The Ohio State University Hospital, The Ohio State University Hospital East, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, OSU Cardiology at Cambridge, OSU Heart Center at Mill Run
Speaking Topics
Cardiac catheterization, left ventricular aneurysm, prosthetic valves


text: "We are disappointed that the Agriculture Committee denied our request to testify at either of the commodity hearings," says NCA president. The House Agriculture Committee Subcommittee on General Farm Commodities & Risk Management finished two days of Farm Bill hearings today with no mention of the outdated and costly U.S. sugar program. The National Confectioners


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2012 Paris - Salon du Cheval Show
Photos from Hussam Altokhais , be sure to visit his page and "like" it on Facebook. http://www.facebook.com/HussamAltokhaisPhotography?fref=ts
2012 Arabian Breeder Finals
Thank you to Show Photographers Darryl Larson & Kelly Campbell for these wonderful images.
Youth Nationals 2012
Photos taken at the 2012 Youth Nationals in Albuquerque by the Arabhorse.com Youth correspondents.
2012 Menton Arabian Horse Championships
the 2012 Menton Arabian Horse Championships
2012 Egyptian Event
The 2012 Egyptian Event is has concluded. With wonderful weather, charming friends and spectacular horses it was an Event to remember. We invite you to enjoy a few great images from this year's Event provided by Photographer Randi Clark.
6th Annual Arabian Breeders World Cup - Cox Kids Day
www.cheapshotzphotography.com Danna Russo Lingard
2012 Scottsdale Show | Schatzberg/Osteen
Enjoy photos from the 2012 Scottsdale Show from the official Show Photographers Osteen/Schaztberg. Print orders are available by visiting: www.osteenschatzbergphotos.com
Rhodium Arabian Stud - New Zealand
Rhodium Arabians, the largest Straight Egyptian stud in New Zealand is located at Isola Equestrian Centre, immediately south of Auckland. Owners Fanus and Ria Crous are dedicated to the breeding of world-class Straight Egyptian Arabian horses and the preservation of the "old SE bloodlines". Arabian horse lineages and strains are carefully researched prior to breeding or making any acquisitions, with the intention to adopt a very scientific and dynamic approach throughout. Rhodium Arabian Stud is a life member of the Pyramid Society and also of the World Arabian Horse Organisation (WAHO).
Ajman Show 2012 Day 2
Day 2 photos from the Ajman Show
2012 Ajman Evening Entertainment.....
HH Sheikh Ammar puts on the most amazing horse show of the whole year.... just a small group of photos of the impressive evening
Ajman Show 2012 Day 1
Photos from the first day of the 2012 Ajman Show
2011 Jordan Show
Photos by Cécile Marleix
Farm Tour Day 4 - Stonewall / Guzzo / North / Midwest
Farm Tour Day 4 - Stonewall Farm / Guzzo & Rivero / North Arabian / Midwest
Farm Tour Day 3 - McNutt / Arabian Expressions / Pomeroy & Aira
Farm Tour Day 3 - Crystal McNutt / Arabian Expressions / Pomeroy & Aira Arabians
Farm Tour Day 3 - McNutt / Arabian Expressions / Pomeroy & Aira
Farm Tour Day 3 - Crystal McNutt / Arabian Expressions / Pomeroy & Aira Arabians


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An estimated 79 million pounds of avocados are expected to be served at parties and other events surrounding the Super Bowl Feb. 3.
That's enough avocados to fill a football field end zone to end zone 30 feet deep, according to a news release from the Irvine, Calif.-based Hass Avocado Board.
This year's expected total would top last year's by close to 8 million pounds. Thirteen years ago, 8 million pounds of avocados were served around the Super Bowl.
The record volumes expected this year are due to continued soaring demand and an enormous Mexican crop.
About 986 million pounds of Mexican avocados will be shipped to the U.S. in 2012-13, up from 782 million pounds in 2011-12, according to the Association of Michoacán State Avocado Producers and Packers (APEAM).
For Super Bowl-themed recipes, tips and fun facts, visit the board's website.


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Refuge Destroyed Boyfriend Jeans
Price $34.99
Special Offer
BUY 1, GET 1 FOR $12.50 Details
Promotional pricing valid for a limited time on select styles only. Excludes sale. Valid on items of equal or lesser value. Discount applied to lowest ticketed item. Discount applied automatically in bag. Offer may vary in Charlotte Russe stores. Offer limited to inventory on hand; no backorders will be taken. Offer cannot be combined with other offers.
Details content below
- Zip fly with top button
- Five pocket cut
- Brands We Love: Refuge
Product Model Size:Model is 5'9" tall
Product Fit:Model is wearing size 4. Size 4 has a 27" inseam and 9" front rise.
Product Care:cotton / polyester / rayon / machine wash / imported
From our Refuge collection! Boys are cute and all, but the new Refuge Boyfriend jeans will really treat a girl right! Thick, colored denim perfects the boyfriend fit in a mid-rise silhouette, with rips and shredded details down the front for an on-trend, destroyed finish. Skinny legs are relaxed, but never baggy with cute, cuffed hems!
Returns content below
Return or exchange in any Charlotte Russe store within 30 days of your ship date, or use the mailing label included in your package to send it back right away.
We do not accept returns on jewelry, swim, intimates, nail polish, fragrance, gift cards, opened beauty products or anything marked as final sale.
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Style: 302360951


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College Basketball in the West
Tribune Power Rankings
1. Arizona (16-1)
College Basketball in the West
Tribune Power Rankings
1. Arizona (16-1)
Pulled away in the second half to down fading Arizona State and regain some momentum for UCLA's visit on Thursday.
2. Gonzaga (17-2)
Having suffered heartbreaking loss at No. 9 Butler, Zags turn their attention to BYU, which also knows the feeling of seeing a big win slip away
3. New Mexico (16-2)
Overtime win at Boise State more impressive than most would believe, because Broncos are having a very good season as well
4. Oregon (16-2)
Ducks have won seven straight since that triple-overtime loss to UTEP, outclassed UCLA at Pauley on Saturday
5. Saint Mary's (15-4)
Gaels got a huge win in Provo despite being outplayed most of the game, should reel off a bunch of wins until Feb. 14 showdown with Gonzaga in Moraga
Disappointing Bruins overpowered by Oregon on their home floor, now must travel to Arizona for a game that has lost some of its luster
Rebels had impressive win at No. 15 San Diego State on Wednesday, only to lose to Colorado State at Moby on Saturday
8. Colorado State (15-3)
Rams have won nine of last 10, with only loss in that stretch an overtime setback at San Diego State; Huge game at New Mexico Wednesday
9. Wyoming (15-2)
Cowboys always give San Diego State fits in Laramie, and that happened again Saturday as they walloped Steve Fisher's team by 13
10. Arizona State (14-4)
Devils have lost two straight, but they still look like the Pac-12's fourth-best team after Washington was stunned at home by Utah


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OAKLAND — Startup toy company GoldieBlox, which encourages girls to pursue careers in math and science, is in the running for free commercial airtime during one of the biggest television events of the year — the Super Bowl.
GoldieBlox was named a finalist in Intuit's (INTU) Small Business competition, which awards one small business with a professionally made, 30-second commercial aired during the Super Bowl. The grand prize winner will be announced before the Feb. 2 championship game.
GoldieBlox is among four finalists. The others are Dairy Poop, a natural dairy compost startup from Idaho; North Carolina-based Barley Labs, which makes natural dog treats out of recycled barley from a local brewery, and Minnesota egg company Locally Laid.
GoldieBlox, started by Stanford University engineering graduate Debbie Sterling, makes a construction-themed toy set and storybook starring the tool-wielding character Goldie. The company has been in a high-profile battle with the Beastie Boys since November, when GoldieBlox aired on YouTube a video spoof of the hip hop group's hit song "Girls." The Beastie Boys sued GoldieBlox last month for copyright and trademark infringement.
Contact Heather Somerville at 510-208-6413. Follow her at Twitter.com/heathersomervil.


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My studio in the early 90s was full of hardware mixers and long patch cable strung all over the place. Before computers with fast CPUs the way to get an original sound was simply plugging hardware boxes into each other. Electrocomp-101 synthesizer into a Boss Pedal into a Korg Digital Delay and so forth. I always felt like a pioneer pushing the equipment to unintended limits.
My favorite trick that I never actually heard anyone else do was something I called the "Wicked 106". I created 16 slightly different patches on a Roland Juno-106. Next, I would create a 16th note pattern in Dr. Ts KCS. Here's the trick: I would then put a different Program Change (number) on each of the steps. You never heard a Juno-106 sound so interesting. It really made the 106 sound like a modular going through a step sequencer.
"What most don't know about the original TR-808, aside from it's original voices (sounds) there is a "pulse" sound that you can hear when plugging a cable from the ACcent trigger out, it generates a metallic "zap" sound very similar to a Hi Q (sound from the Roland R-8) This sound was used in "Egypt Egypt" and "Funkbox" from Masterdon. THIS IS HOW THE SOUND IS DONE!!!!" – intromix
Do you remember an old hardware trick you used to do?


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Posted 6 years ago
(304 items)
I love vintage night gowns and wear them every night. These are a few of my favorites. I have a huge collection of vintage clothing and I keep finding more and better pieces every week. Cant wait to see what I find this week. Thanks for looking!


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629 members44 Likes
Hi Charles,
Merry Christmas & a Blessed & Prosperous 2011.
Welcome to the community. I hope your membership here improves your life. Let me know how I can help you with anything.
Feel free to make friends, join groups, add discussions, give advice, anything to assist your fellow community members.
To help you get started, here's a free ebook from Raymond Aaron I think you might enjoy: Double Your Income Doing What You Love
God bless...
© 2017 Created by Jon Dale. Powered by


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Herb is a 4-year-old male Akita mix dog available for adoption at the shelter.
He has been at the shelter since August and would love to have a forever family all this own. He is a high energy dog who would love an active family.
He is a sweetheart and knows 'sit' and 'stay'. He is a large dog who would be best in a home without cats, small dogs or young children.
He is an excellent running dog and would be best in a family who will keep him forever.
For more information on Herb, please contact the Oakland Pet Adoption Center at 248-391-4100 or www.oakgov.com/petadoption.


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As previously reported on Joystiq, Fallout 3 has taken over Metro Center in Washington DC. If you're in the area, I highly recommend checking it out. When I took a visit last week, it was a trip seeing different people staring and talking about the displays. When I talked to this guy shown below, he marveled at the image and wondered if it was from another movie like 300.
If you're not able to see them in person, I've included some new photos from various locations within Metro Center. Oh yeah, and head to our Fallout 3 Official site to download three new wallpapers based on the Metro advertising.
To see more images from the metro, hit the jump below.


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As average climbs, Gennett climbs in order
MILWAUKEE -- With due respect to the hitting prowess of Brewers pitchers, second baseman Scooter Gennett won the lottery this week when he moved from the eighth spot in the batting order to second, in front of Ryan Braun.
"I just want at-bats, period, but when Braun is behind you, it's a little better," Gennett said. "I'm not saying our pitchers can't hit, but Braun is just a little better."
In theory, Gennett should see more fastballs in the two-hole from opposing pitchers unwilling to put him on base in front of the dangerous Braun. That did not necessarily help the previous occupant of the two-hole, shortstop Jean Segura, who was dropped in the order this week, manager Ron Roenicke said, in order to relieve Segura of some pressure.
Gennett went 4-for-9 with a double and a home run in his first two games hitting high in the order, with a run scored and an RBI in each of the games.
"In front of Ryan Braun would be nice to hit," Roenicke said. "I hit in front of Mike Schmidt one [year], that was nice to do. Surprisingly, I walked some, and Mike Schmidt came to me and he says, 'How can they walk you when I'm hitting behind you?' He didn't mean it [offensively]. He was right!
"I think over the long run you do [see better pitches hitting second], but from game to game, I don't know if there's that much difference. [As a pitcher], you know going into a game what your strategy is against certain hitters, and what it comes down to is if your command is off that day and you get behind in the counts, now you have to look at what's happening with that [next] hitter. But if [the pitcher's] command is on, you really don't get pitched differently."
Gennett had been feeling better at the plate before Roenicke shuffled the lineup but remains in a platoon at second base alongside Rickie Weeks. Gennett starts the majority of games because the vast majority of starting pitchers are right-handed, and Roenicke said this week that the arrangement will continue. Weeks entered Wednesday with a .120/.154/.160 slash line in 25 at-bats compared with Gennett's .322/.355/.458 in 59 at-bats.
Since Aug. 5 of last season, when Gennett started playing every day because Weeks was down with a hamstring injury, only the Rockies' Charlie Blackmon has a better batting average than Gennett among players with at least 220 at-bats. Blackmon entered Wednesday hitting .365 since then, and Gennett .348.
"It's not like a midseason feeling, but I'm feeling more comfortable," Gennett said. "My at-bats are more consistent."
Would he ever ask for some at-bats against left-handed pitchers?
"No, I don't really ask for anything," he said. "That's their call, their decision. We're going to do whatever we can to get people on base and win ballgames, and they do what they want to do. I'm just happy to be an option and be part of winning."
Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. This story was not subject to the approval of Major League Baseball or its clubs.


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Mariners sign right-handed pitcher Jon Garland to minor league deal
Seattle Mariners Executive Vice President & General Manager of Baseball Operations Jack Zduriencik announced today the club has signed right-handed pitcher Jon Garland to a minor league contract with an invitation to Major League spring training.
The Mariners have now invited 20 players to Major League Spring Training, including 12 pitchers (RHP – 10, LHP – 2), 4 catchers and 4 infielders. This is in addition to the current 40-man roster.
Garland, 33, is a veteran of 12 Major League seasons with the Chicago White Sox (2000-2007), Los Angeles Angels (2008), Arizona Diamondbacks (2009), the Los Angeles Dodgers (2009 and 2011) and San Diego Padres (2010). Garland, who did not pitch in 2012 recovering from a right shoulder injury, is 132-119 with a 4.32 ERA in 353 games, 330 starts in his career.
Garland averaged over 32 starts and 200.0 innings per from 2002-09, and was selected as an American League All-Star in 2005. Garland helped lead the White Sox to a World Series championship in 2005, going 1-0 with a 2.25 ERA in his two postseason starts. He tossed a complete game in his postseason debut, striking out 7 and allowing 2 runs on 4 hits in Game 3 of the American League Championship Series against the Angels.
The native of Valencia, Calif., was originally selected by the Chicago Cubs in the first round (10th overall) in the 1997 June draft out of Kennedy High School in Granada Hills, where he was named a High School All-American as senior.


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This game was classified by the community with the following category scores - Violence=2/3, Sex=0/3, Mature Content=1/3. Happy Halloween ! Control Batboy to Fly and collect 12 candies to win the game. Watch out though because some treats are tricky ! This is a different type of flying skill game.
Buy Xbox content on Xbox.com. Your Xbox 360 console will automatically download the content next time you turn it on and connect to Xbox Live.Learn More


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|I'm not claiming this recipe for Red Lentil Dal is 100% authentically Indian, but it's easy and delicious.
(Makes 6-8 servings as a side dish or snack, recipe adapted from Betty Crocker Easy Indian.)
2 cups dried red lentils, rinsed, and drained
1 tsp. ground turmeric
5 cups water
2 T grapeseed oil (or other neutral-flavored oil)
2 tsp. cumin seeds
2 small onions, chopped
2 T finely diced fresh ginger root
1 can (4 oz.) diced anaheim chiles with juice (or for more heat use 3 fresh Thai, Serrano, or Cayenne peppers, seeds removed and chopped)
1 tsp. salt
chopped cilantro or sliced green onions for garnish (optional)
More Tasty Dal Variations to Try:
(Recipes from other blogs not always South Beach Diet friendly; check ingredients.)
Bengali Red Dal Curry from Jake from Kalyn's Kitchen
Spiced Vegetable Dal from Andrea Meyers
Dal Makhani, Oberoi Style from A Life (time) of Cooking
Andrha Tomato Dal from Sailu's Kitchen
Basic Yellow Split Pea Dal from Viet World Kitchen
(Want even more recipes? I find these recipes from other blogs using Food Blog Search.)


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Click on the headline (link) for the full text.
Many more articles are available through the Energy Bulletin homepage.
Mr. Darcy's earth shattering results
Peter Tertzakian, Calgary Herald
A flashback to history provides the background we need to understand why there is a technological revolution happening in the oil and gas industry and why peak oil theorists may need to go back to math class.
… Darcy's Law, as applied to an oil well, says that the proprietor can do three things to improve the flow of his hydrocarbon treasure: (1) increase the pressure difference between the oil at the bottom of the hole relative to the surface; (2) enlarge the contact area between the sides of the well bore and the oil-bearing rock; or (3) open up the pores in the rock to channel more oil into the well (otherwise known as increasing the 'permeability').
For the first 100 years of the industry, up to about the mid-20th century, oilmen mostly left Darcy's Law to nature. Back then it was relatively easy to find high-quality oil reservoirs with high enough pressure and permeability to push the fluid all the way up a vertical hole in the ground with no artificial intervention. But by the 1960s, it was getting harder to find wells that naturally optimized Darcy's formula. After most of the high-pressure 'gushers' had been discovered (and brought under control by John Wayne) human intervention was needed to juice Darcy's Law – without destroying the well, of course.
Engineers dusted off Darcy's formula. Tinkering with the pressure dimension was the first place to start. Pumps and compressors were introduced on wells to either push or suck the hydrocarbons out of the ground with greater and greater vigor. Techniques included pumping water down into oil reservoirs, a common practice called 'water flooding,' that pushed trapped oil up a producing well.
… Peak oil theorists, among others, have held to the notion that the diminishing number of gushers found over time, combined with progressively 'maturing' wells that can't be pumped any harder, ultimately point to irreversible, downward trend lines for oil production. In part, this belief has assumed that rock permeability is a geological fixture that human ingenuity could not easily alter. Merit remains in some peak oil arguments, but in the last 10 years the industry has come full circle on Darcy's Law, a largely unexpected event. No retro futurist, except those driven by ingenuity, counted on a resurgence of modern day 'torpedoing'; in other words, man's ability to inflict large-scale changes to Darcy's calculus of flow through large-scale changes to permeability.
… If past tinkering with Darcy's Law is any indication of future potential, the oil and gas industry is once again on a path to renewal for several decades to come.
(13 February 2012)
Four Scenarios For The Future Of Energy
Ariel Schwartz, Co.Exist
We are reaching an historical inflection point, where our current decisions about energy use and carbon will have major effects on how we live in coming decades. Here are four possible scenarios for what things will be like in 2025.
Growth: A Rising Tide
In this optimistic scenario, peak oil is reached in 2024. Both fossil fuels and renewable energy sources play a big part in the energy market, but cost parity is near for renewables, which means they're about to gain an edge. Wise investments in the smart grid and new sources of energy have generated millions of green jobs. A robust energy infrastructure uses the 20th-century grid as a backbone but is filled with smart-grid upgrades. Unfortunately, temperatures are still rising. Instead of attempting to stop temperatures from rising further, we focus on geoengineering and other adaptation techniques.
Constraint: Sharing the Load
The government has taken direct control over the energy industry thanks to massive oil spills, nuclear disasters, and record profits for oil companies. In this scenario, renewables never even had a chance to reach grid parity–mandatory government efficiency requirements have forced people to curb energy use. Sensors and smart meters set household thermostats at optimal regional levels, and local energy sharing is beginning to look attractive. People have enough energy for their needs, but no more.
(13 February 2012)
Le pic de pétrole passé depuis 2005 ? Un expert (Jean Laherrère) nous répond
Bruno Scala, Futura-Sciences
Le pic pétrolier aurait eu lieu en 2005 selon de récentes analyses. Une nouvelle annonce qui montre à quel point le problème est complexe. Jean Laherrère, directeur de l'Assocation pour l'étude du pic pétrolier (Aspo France), interviewé par Futura-Sciences, apporte des précisions.
… Enfin, la production mondiale tous liquides (« oil supply ») est depuis 2005 sur un plateau qui varie avec une oscillation de l'ordre de l'incertitude des mesures. Les affirmations sur un pic pétrolier pour une certaine année sont donc peu fiables (celles pour un jour précis, comme Kenneth Deffeyes qui a prévu le pic pour le 16 décembre 2005, ridicules) car nous sommes dans un plateau et personne ne peut dire quand un déclin significatif va se produire.
Futura-Sciences : Est-ce que d'éventuels progrès concernant les techniques de détection, d'extraction permettront un jour d'augmenter à nouveau la production et d'éviter ce déclin ?
Jean Laherrère : Les grandes avancées de détection sont la sismique grâce à l'utilisation de davantage de sismographes, de 3D et 4D [la quatrième dimension étant le temps, NDLR], mais seuls les forages peuvent statuer sur la présence de pétrole et préciser les profondeurs et épaisseurs.
… Concernant l'extraction, le taux de récupération (variant pratiquement de 0 à 100 %) dépend principalement de la qualité du réservoir.
… Futura-Sciences : Est-ce que vous considérez que nous sommes assez préparés à ce déclin ?
Jean Laherrère : Nous ne sommes pas du tout préparés à ce déclin. La société de consommation est basée sur la croissance (du PIB qui est un mauvais indicateur car il représente les dépenses et non la richesse), mais une croissance constante est impossible dans un monde fini. Notre mode de vie doit changer mais ce message, personne ne veut l'entendre. Après le pétrole, c'est le gaz et le charbon qui déclineront.
(13 February 2012)
This would be a great article to have available in English. If you see it online, please let us know so we can link to it ( [email protected] ) -BA
UPDATE: Terry Berg kindly translated the article into English. It is in the Comments below.
Flawed views on peak oil rear their ugly heads again
Robin Mills, The National
The debate over peak oil is stalked by zombie ideas that live on, no matter how many times they are stamped upon. The latest significant article warning of declining oil supplies manages to revive not just one but at least six of these false concepts.
… The idea that oil production has not risen above 74 million barrels per day (bpd) since 2005 relies on a very narrow definition of "crude oil". In reality, oil demand is now met from a range of sources, including biofuels and petroleum extracted from natural gas.
To the motorist, the end product is indistinguishable. Figures from the US Energy Information Administrationsuggest that, for the first time, total production topped 90 million bpd at the end of last year.
Automatically ascribing a slowdown in production growth to physical resource constraints fails to consider the economic and policy context.
… And with more than a century's worth of resources of both coal and natural gas, it does not matter whether reserves are somewhat overstated. The production of coal, in particular, is constrained by economics and environmental concerns, not by physical availability.
The final piece in the peak-oil puzzle is the idea that declining oil production must bring a halt to economic growth. But Michael Levi from the US-based Council on Foreign Relations notes in a comprehensive demolition of the Nature article that the American economy has persistently grown much faster than its oil consumption.
(14 February 2012)
Ex-Shell CEO Hofmeister takes on Tad Patzek in debate on oil crisis
Former Shell CEO, University of Texas Oil Expert To Debate Possible 2012 Oil Crisis
Who: John Hofmeister, Former President, Shell Oil Company
Tad Patzek, Chair, Dept. of Petroleum Engineering, University of Texas
What: Debate on World Oil Supply: Looming Crisis or New Abundance?
When: Tuesday, February 14, 2012, 6:00 – 7:30 pm
(refreshments: 5:30 pm, reception: 7:30 pm)
Where: University of Wisconsin – Madison
Varsity Hall, Union South, 1308 West Dayton Street, Madison, WI 53715
Gasoline will hit $5 per gallon this year, predicts John Hofmeister, former president of Shell Oil Company, the U.S. subsidiary of Royal Dutch Shell. He points to rising demand by developing countries, especially China and India, and says that the recent increase in U.S. oil supply rates and decrease in demand is not enough to offset global trends, and that prices will continue to creep upward, unless there are major changes in public policy to substantially increase domestic U.S. supply.
Gasoline prices could suddenly spike even higher, and though increases in U.S. domestic supply may be important, no realistic U.S. increase will offset declining yields from other nations, according to Professor Tadeusz Patzek, chair of the Department of Petroleum and Geosystems Engineering at the University of Texas at Austin, and vice-president of ASPO-USA's board of directors. He highlights that declining output from most oil-exporting nations over the past decade, in the face of rising global demand, is likely to create a lasting drop-off in global availability of oil—spelling serious consequences for all oil-importing nations, including the United States. Building an economy that runs on half as much oil is essential and unavoidable, according to Dr. Patzek.
Regardless of who is right, this issue needs to be examined with seriousness and urgency, which has been the driving motivation behind the collaboration of multiple University of Wisconsin and local Madison groups that are co-sponsoring this event.
About John Hofmeister
Former President, Shell Oil Company
Author, Why We Hate the Oil Companies
Member, US National Energy Security Council
Founder, Citizens for Affordable Energy http://www.citizensforaffordableenergy.org/
About Dr. Tadeusz Patzek
Chair, Dept. of Petroleum & Geosystems Engineering, University of Texas at Austin
Co-author, Drilling Down: The Gulf Oil Debacle and Our Energy Dilemma
Vice-President, Association for the Study of Peak Oil & Gas USA
(13 February 2012)


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It's simple logic, right? After nearly two months of top-10 purgatory, the Hoosiers (20-2) should return atop the college basketball mountain.
Sure, No. 4 Florida (17-2) could make a push given it is 8-0 in the mediocre SEC, but that's not likely. The Big Ten is the nation's best conference and IU has proven, to the halfway point, that it is the best of the best.
Until the next test — Thursday at Illinois.
Beating Michigan 81-73 Saturday night showcased all that is right with the Hoosiers — the balanced scoring (five players in double figures, led by Cody Zeller's 19), the relentless rebounding (a 38-29 edge with Zeller and Christian Watford both grabbing 10), the ruthless attacking of the basket that produces a nation-leading free throw advantage (IU was 22-for-25 to Michigan's 6-for-7) and, of course, the full-throttle approach that makes it all possible.
IU is wiser from its first run at No. 1, which lasted from last April until the mid-December overtime loss to Butler. It will not, guard Victor Oladipo said, change the Hoosiers' approach.
"We'll play like we've been playing," he said. "We're playing with a chip on our shoulder. We've played with a chip on our shoulder since I got here. We'll continue to do that. We'll continue getting better, keep playing for each other and staying with each other."
The Hoosiers weren't flawless. They turned it over more times than Ray Lewis denied using deer antler spray, 16 times in all, twice as many as they had three days earlier at Purdue. They blew a 15-point first half lead, nearly blew an 11-point second-half edge.
But that's just nit-picking. Michigan wasn't No. 1 without reason. The Wolverines (20-2) forced mistakes, then capitalized. They will be hard to handle in next month's rematch in Ann Arbor.
But that's getting WAY ahead of ourselves.
Today's top ranking can disappear in an instant, as it has for IU, Duke, Louisville, Michigan, and even Kansas if you count the coaches' poll. It is, in fact, the fourth straight week the No. 1 team lost, which reflects the parity of today's game and the wide-open certainty of the upcoming NCAA tourney.
IU coach Tom Crean understands that. The Hoosiers lost to Butler in Indianapolis and Wisconsin at Assembly Hall, but that didn't alter his perception of his team's potential.
"We were picked No. 1 back in April, but we hadn't done anything," he said. "All of a sudden, when you lose, it was like, how did you lose? We picked you No. 1.
"That's not what they play for. That's great (to be No. 1). They are learning those things are nice, but you play to improve. You play to be good enough to win a game like this. You play to be able to make adjustments and play through some mistakes and deal with some adversity and grow up in a game. That's what is most important.
"I don't get the sense these guys are locked into those rankings at all. When we weren't No. 1, they know what was said. They can feel all that. Were we any worse because we lost by two (in overtime to Butler)? We didn't play that great that day. It wasn't like the sky was falling. We had to make sure they understood that."
So now IU has the Big Ten lead with an 8-1 record. Right behind with 7-2 records are Michigan, Michigan State and Ohio State. Right behind them is Wisconsin (5-3). In the coming weeks the Hoosiers will play Ohio State twice, and Michigan and Michigan State once.
They control their own destiny. They can prove the merit to their ranking and all the hype. They can win the national title that has eluded the program since 1987.
"When a team loses sight of the most important thing of how they play together and how they improve together, then you have issues," Crean said. "We don't plan to have any issues. We plan on making sure we stay locked into that and not let any of the nice things or negative things become a driving force. It's all part of the game.
"These guys have figured out that if they're not improving, A) somebody else in the program will and B) all these other teams are improving. So we have to be."
Crean will give the Hoosiers a day off to think about that. He's heading to New Orleans and the Super Bowl to watch his brothers-in-law — Baltimore's John Harbaugh and San Francisco's Jim Harbaugh — battle for the NFL's top prize.
They succeed, he said, because of team over everything else.
If the Hoosiers buy into that, everything else falls into place.
More Information
Up nextTipoff: Indiana at Illinois, 7 p.m. Thursday night
Online: For more on Indiana athletics, follow Pete DiPrimio via Twitter at pdiprimio.


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Something seems fishy about this. Anya has been an IU lean since like May. He was the first guy to really lean IU out of this group. Maybe we know for sure Vonleh is coming?
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Something seems fishy about this. Anya has been an IU lean since like May. He was the first guy to really lean IU out of this group. Maybe we know for sure Vonleh is coming?
No, Vonleh isn't deciding before he visits us or OSU.
Either something changed on our end, something like Zeller saying he was planning on staying. Or Anya decided that he wanted to stay close to home. It is possible that they wowed him as well.
We were recruiting both of them as if we were trying to get both, so I doubt Crean would just give up unless something changed. And judging by the fact that NC state had already stopped recruiting the other big. They must have realized one way or the other that they have Anya locked up.
Like anything else, it was probably a combination of things: Word might have leaked back to the Hoosier staff that Anya was leaning NC State; word might have leaked back to the staff that if IU took Anya, Vonleh would knock them down his list; we might have realized (for once) that we have a very real scholarship crunch if we took all three of them, so they suspended their pursuit of Anya in hopes of landing their top target Vonleh; or a combination of those things led IU to announce it was saving their last space for Vonleh as a recruiting tool to make him feel all warm and fuzzy for IU. All very plausible explanations.
All in for Vonleh! That's what I wanted. Get em Crean!
Perea and Jurkin are eligible for tomororw and most are assuming this means the NCAA issues are cleare dup.
I hope so.
Some positive football publicity: http://footballrecruiting.rivals.com...sp?CID=1430244
Take me out to the black, tell 'em I ain't coming back. Burn the land and boil the sea, you can't take the sky from me.
Wow, Sudfeld gets him his first Big Ten win and he still starts Coffman. Unbelievable
Really don't understand Wilson's insistence on starting Coffman.
Wow. Sudfeld into the game; first pass is a pick 6. Uh oh.
Wasnt sudfelds fault though. Jeez i dont think a team could be more confused about a run up the middle
Ehhh...it was a poor route but he telegraphed that pass to the defender.
Coffman has played better today.
Houston not having a good game jeez
Yeah Coffman did end up playing alot better.
Next week is easily the most important game in 5 years. If they pull that out, you have to like their chances. They have to play OSU and Penn State. We have to play Purdue and Penn State.
FYI, Ron Patterson committed to Syracuse
Big Ten is so bad at football. We should be bowl eligible right now if we could just beat Navy and Ball State. Blah.
I havent been this stoked about IU football in a long time. Kevin Wilson is turning this program around. Now we just need the fans to start showing up.
IU football is coming around and the #1 team in the country opens the college basketball season on Friday.
It is good to be a Hoosier fan.
Indeed it is an exciting time to be a Hoosiers fan. I'm hoping that alums coming into town for the basketball opener on Friday night will stick around and go to the football game on Saturday. I nabbed some tickets to the Bryant game, and I'm planning on a football Saturday as well.
Take me out to the black, tell 'em I ain't coming back. Burn the land and boil the sea, you can't take the sky from me.
Early in the season I said a lot of things about Wilson I'm not proud of.....wow has he turned things around.
Who would have thought two months ago that IU would still be alive in the race to Indy while Purdue would be 0-fer and about to fire their coach?
Here's a Terry Hutchins blog about their eligibility status. He doesn't seem to know what to think.
So the fact that Jurkin did play and Perea could have makes me think this "all part of the process thing" has some legs. The one thing we know for certain is that the NCAA has never been quick to get players through the clearinghouse. The only problem here is that Indiana opens its season Friday night at Assembly Hall against Bryant. One would hope that there is official word by then.
I think Jurkin will not miss any games, and Perea will miss a handful.
Dopirak tweets: Peter Jurkin and Hanner Mosquera Perea have each been required to sit out nine games and donate money to charity.
Take me out to the black, tell 'em I ain't coming back. Burn the land and boil the sea, you can't take the sky from me.


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Pharmacokinetic Evaluation of Changes in Nevirapine AUC Due to Differences in Weight (NAWS)
This study has been completed.
Western University of Health Sciences
Jeffrey Goodman Clinic, LA Gay & Lesbian Center
Information provided by:
Western University of Health Sciences
ClinicalTrials.gov Identifier:
First received: December 7, 2010
Last updated: April 12, 2011
Last verified: April 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Biospecimen Retention: None Retained
Show Detailed Description
This study would be a prospective cohort study, stratified by weight. Patients who are stable on nevirapine for at least 3 months prior to study entry, but no more than 1year will be recruited. For 1 week, subjects will take their morning dose of nevirapine in the clinic (and be observed taking it), and given their evening dose to take at home. Subjects will need to record the date and time they take their evening dose. At the end of the week, the subjects will be sequestered at the clinic for blood draws for a 12hr pharmacokinetic sampling. They will not be brought back in at 24hrs as they will need to be redosed after 12hrs. They will have Liver Function Tests (LFT's) and other labs drawn at study entry, and one month after the end of study. Pharmacokinetic levels will be analyzed using standard mathematical models, and Area Under the Curve (AUC), Maximum concentration (Cmax), and Minimum Concentration (Cmin) will be compared between groups.
|HIV Infection
|Drug: Nevirapine
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:
|Pharmacokinetic Evaluation of Changes in Nevirapine AUC Due to Differences in Weight
Resource links provided by NLM:
MedlinePlus related topics: Body Weight HIV/AIDS
Drug Information available for: NevirapineU.S. FDA Resources
Further study details as provided by Western University of Health Sciences:
Primary Outcome Measures:
- Differences in AUC based on weight/BMI [ Time Frame: 12 hours ]This study was a "snapshot" of the PK levels following ingestion, and then compared AUC to weight and BMI.
Biospecimen Retention: None Retained
Levels were drawn prior to dosing, and at the following time intervals: 0.5hr, 1hr, 1.5hr, 2hr, 4hr, 6hr, 8hr, 12hr. ~10cc of blood were drawn with each sample, centrifuged, and plasma separated into 2 cryovials. Samples were then frozen at -20oC. All samples (216) weresent to Consolidated Laboratory Services for level determination by appropriate means. All samples have now been destroyed.
|Study Start Date:
|May 2003
|Study Completion Date:
|June 2003
|Primary Completion Date:
|May 2003 (Final data collection date for primary outcome measure)
|Assigned Interventions
Subjects >80kg
As above
Drug: Nevirapine
200mg twice daily of nevirapine
Subjects <70kg
As above
Drug: Nevirapine
200mg twice daily of nevirapine
Subjects 70-80kg
As above
Drug: Nevirapine
200mg twice daily of nevirapine
Show Detailed Description
|Ages Eligible for Study:
|18 Years to 50 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Study Population
HIV positive patients stable on a nevirapine containing regimen for at least 3 months
Inclusion criteria:
- Documented HIV infection
- 18-50yrs of age
- Male
- Currently on nevirapine therapy for at least 3 months
- LFT's < 2 times normal limits within one month prior to study date
- In good health as judged by their primary care provider or a study provider within one month of the study date
- Willing to abstain for 1 week prior to study date
- No active opportunistic infections within one month prior to the study date
- Willingness to sign informed consent
Exclusion criteria:
- Active substance abuse
- Poor self reported adherence to nevirapine therapy
- Chronic liver disease or active hepatitis
- Concurrent administration of medications with a known or suspected pharmacokinetic drug interaction with nevirapine (such as …)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01335360
Please refer to this study by its ClinicalTrials.gov identifier: NCT01335360
|United States, California
|Jeffrey Goodman Clinic
|Los Angeles, California, United States, 90028
Sponsors and Collaborators
Western University of Health Sciences
Jeffrey Goodman Clinic, LA Gay & Lesbian Center
|Principal Investigator:
|James D Scott, PharmD
|Western University of Health Sciences
More Information
Keywords provided by Western University of Health Sciences:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
|Responsible Party:
|James D. Scott, PharmD, Associate Professor, Western University
|ClinicalTrials.gov Identifier:
|NCT01335360 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 7, 2010
|Last Updated:
|April 12, 2011
Keywords provided by Western University of Health Sciences:
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
Cytochrome P-450 CYP3A Inducers
Cytochrome P-450 Enzyme Inducers
ClinicalTrials.gov processed this record on September 25, 2017


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Ask Oprah, and she'll tell you she'd invite Jesus to her dream dinner party…(watch the clip below)
Ask us, and well, after last week, we might have to say Felder Rushing. IMA TV stopped to chat with the Southern gentleman in the Oldfields orchard while he was at the IMA for his talk as part of our Planet Indy series. Check out the latest IMA TV episode and you'll see why we're crazy for this offbeat gardening guru.
Filed under: Education, Horticulture, IMA TV, Interviews, New Media, The Toby