text:
A Study of 1592U89 in Combination With Protease Inhibitors in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs
This study has been completed.
Glaxo Wellcome
Information provided by:
NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov Identifier:
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: November 1998
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to see if it is safe and effective to give 1592U89 plus certain protease inhibitors (PIs) to HIV-infected patients who never have been treated with anti-HIV drugs. This study also examines how the body processes these drugs when they are given together.
|HIV Infections
|Drug: Indinavir sulfate Drug: Ritonavir Drug: Abacavir sulfate Drug: Amprenavir Drug: Nelfinavir mesylate Drug: Saquinavir
|Phase 2
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|An Open-Label, Phase II Trial to Evaluate the Steady-State Pharmacokinetics, Safety, and Efficacy of 1592U89 in Combination With Selected HIV-1 Protease Inhibitors in Antiretroviral-Naive, HIV-1-Infected Patients.
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Abacavir sulfateU.S. FDA Resources
Further study details as provided by NIH AIDS Clinical Trials Information Service:
|Ages Eligible for Study:
|16 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Concurrent Medication:
- Local treatment for Kaposi's sarcoma.
- GM-CSF, G-CSF or erythropoietin.
Patients must have:
- HIV-1 infection documented by a licensed HIV-1 antibody ELISA and confirmed by Western blot detection of HIV-1 antibody or a positive HIV-1 blood culture.
- CD4+ cell count >= 100 cells/mm3 within 14 days of study drug administration.
- HIV-1 RNA >= 5,000 copies/ml within 14 days of study drug administration.
- No active or ongoing AIDS-defining opportunistic infection or disease.
- Signed, informed consent from parent or legal guardian for patients less than 18 years of age.
Prior Medication:
Local treatment for Kaposi's sarcoma.
Exclusion Criteria
Co-existing Condition:
Patients with the following conditions or symptoms are excluded:
- Malabsorption syndrome, or other gastrointestinal dysfunction, that might interfere with drug absorption or render the patient unable to take oral medication.
- Life-threatening infection or other serious medical condition that may compromise a patient's safety.
Concurrent Medication:
- Other investigational agents. NOTE:
- Those available through Treatment IND or expanded access programs are evaluated individually.
- Chemotherapeutic agents for the initial 24 weeks of study (except local treatment for Kaposi's sarcoma).
- Agents with documented anti-HIV activity in vitro.
- Foscarnet.
- Immunomodulating agents such as systemic corticosteroids, interleukins, thalidomide, anti-cytokine agents or interferons.
- Antioxidants.
Concurrent Treatment:
Radiation therapy within the first 24 weeks of study.
Patients with the following prior conditions are excluded:
- History of clinically relevant pancreatitis or hepatitis within the last 6 months.
- Participation in an investigational HIV-1 vaccine trial.
Prior Medication:
- Antiretroviral therapy, including reverse transcriptase inhibitor and protease inhibitor therapy.
- Cytotoxic chemotherapeutic agents within 30 days of study drug administration.
- HIV-1 vaccine dose within the 3 months prior to study drug administration.
- Immunomodulating agents, such as systemic corticosteroids, interleukins or interferons within 30 days of study drug administration.
Prior Treatment:
Radiation therapy within 30 days of study drug administration. Alcohol or illicit drug use that may interfere with patient compliance.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002440
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002440
|United States, California
|UCSD Treatment Ctr
|San Diego, California, United States, 921036329
|United States, Connecticut
|Yale U / New Haven Med Ctr / AIDS Clinical Trials Unit
|New Haven, Connecticut, United States, 065102483
|United States, Missouri
|Kansas City AIDS Research Consortium
|Kansas City, Missouri, United States, 64111
|United States, New York
|NYU Med Ctr / Dept of Medicine / AIDS Clinical Trial
|New York, New York, United States, 10016
|United States, North Carolina
|Carolinas Med Ctr
|Charlotte, North Carolina, United States, 28232
|United States, Ohio
|Case Western Reserve Univ / AIDS Clinical Trials Unit
|Cleveland, Ohio, United States, 44106
|United States, Pennsylvania
|Univ of Pittsburgh Med Ctr
|Pittsburgh, Pennsylvania, United States, 15213
|United States, Tennessee
|Vanderbilt Univ Med Ctr
|Nashville, Tennessee, United States, 372321302
Sponsors and Collaborators
Glaxo Wellcome
More Information
Keywords provided by NIH AIDS Clinical Trials Information Service:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00002440 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 2, 1999
|Last Updated:
|June 23, 2005
Keywords provided by NIH AIDS Clinical Trials Information Service:
Drug Therapy, Combination
HIV Protease Inhibitors
HIV-1 Reverse Transcriptase
HIV Protease
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Antibiotics, Antitubercular
Antitubercular Agents
Anti-Bacterial Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
GBS Seminar: Global Branding Strategy
This event occurred in the past
Date and Time
- Monday, August 26, 2013 from 6:00 p.m. to 9:00 p.m.
Coronado, 230
August 26 and 28 (6 hours total) 6 - 9 p.m.
The intensity of competition across industries has tremendously increased in recent years. In this context, most organizations have become more strategic and focused on simultaneously developing brand strategies to obtain better positioning in their markets, increase their revenues, and explore potential opportunities abroad. Regardless of their size or location, for most organizations the notion of brand has gained a tremendous financial value over the last ten years, along with the internationalization process of these brands. Companies are now competing for consumers worldwide and the playing field is not always fair, as more prominent brands often easily build barriers to entry. In addition, there are some inherent obstacles such as norms, legal constraints, hyper-competitive environments or differences in consumption habits that may further hinder the brand internationalization process. This seminar will describe how to strategically plan and implement brand internationalization.
Seminar participants will develop an understanding of branding issues and learn how to internationalize a brand. A number of branding and internationalization concepts will be examined and discussed in the seminar from a practical perspective. There will be a strong emphasis on practical case resolution throughout the seminar, enabling students to apply theoretical knowledge towards decision making in real situations.
Learning Objectives:
- Uncover the basic tenets of internationalization processes and brand issues
- Identify and detail the key variables in developing international marketing and branding decisions.
- Develop and recommend global marketing strategies in practical situations.
Seminar Leader:
Dr. Pons is Full Professor of Marketing at Laval University (Québec, Canada), where he is currently teaching Consumer Behavior, International Marketing and Marketing Research. He has conducted research and led consulting projects in the United States, Canada, France, Hong Kong, Mexico and Lebanon. Dr. Pons has received several teaching awards, and has taught in the United States, Spain, Canada, Lebanon and France.
He has been an invited speaker at the ESSEC business school (Paris), HEC Montréal and the Ecole Superieure de Gestion (Beirut), and has published research in the Journal of Consumer Psychology, Journal of Service Research, Journal of Business Research, Psychology and Marketing, Journal of International Business Studies and Sport Marketing Quarterly. In addition, he has presented papers at more than 50 international conferences and serves on several editorial boards of prominent academic journals. His research interests include consumer behavior, international marketing, strategy and sports marketing.

subset: commoncrawl


text:
Topic: Hard day
I am having a difficult day- does it get any better- how and when?
cholangiocarcinoma.org :: Cholangiocarcinoma Foundation Discussion Board
a resource for patients, friends, caregivers and loved ones.
You are not logged in. Please login or register.
|La fundación de colangiocarcinoma (CCF) ahora ofrece servicios de traducción en Español.
Por favor publique sus preguntas en Español y un intérprete le va responder.
Join our new Mentoring Program
A new discussion board experience is coming this September!
After 10 years, we're upgrading our discussion board to a new modern system. The new forum will be easier to use, mobile-friendly and loaded with new features! We'll be taking all of the existing posts and users over to the new board, you won't have to do anything. If you have any questions, we've started a thread here to discuss.
I am having a difficult day- does it get any better- how and when?
CM, in what way are you having a bad day? You can e mail me if you like as sometimes it just helps to pound it out. Or, if you want to talk....email me your phone number. The really bad days just sneak in there now and then. That's when I would get in to the car and drive a few blocks and first I would let out a scream, then I would listen to Mama Mia and sing loud until my throat got raspy. Only took a few minutes but it sure felt good after. Wish I could take away everyone's "bad" days. Sending big hugs!
Just know that others are thinking of you and hoping you get over this hump. I wish I had words to help. That is all we hear from people, "I wish I knew what to say."
I just look at my mom when she is having a rough time and just say, "This Sucks!!!!" That is all I have.
Feel better.
MN and CM I am a little Cheerleader!
Life is not the way it's supposed to be. It's the way it is. The way you cope with it is what makes the difference."
When God solves my problems I have faith in his abilities, when he doesn't solve my problems he has faith in my abilities!
mn.....The t-shirt of one of our members read: CANCER SUCKS. I couldn
Lainy - I read your post about getting in your car and driving -
For a year after my mother passed away, every time I got into the car to drive to work or when I drove home from work, the tears would just flow! - as soon as I arrived at work or home, I wiped my face and went on with my day (or night) - my car was a private sanctuary where I could let go and then re-group -
So I hope you can find a time/place where you can get some relief - even a warm soak in the tub helps!
The car is my sanctuary too.... how funny that it's the same for so many people. I still cry MUCH more often when I am driving alone then any other time. I can think and feel freely, it's quiet (or there's a good song on that makes me think of Dad), and there's nobody to interrupt my grief. I feel much better afterwords, so I let it happen without holding back.
CM - I am thinking of you, and hope you are having a better day today.
Thanks everyone-
I am sorry for being down- I try so hard to be up sometimes it all falls down-
I am tired of being sad- I feel physcially different, heavier. I look at photos of us together and I remember how happy we were. I long to feel that lightness and happiness but is is gone. Grief is consuming and it comes in waves when I am least expecting it- I was on the phone to my sister and her husband was laughing a really hearty laugh with their two kids in the background- should be a lovely sound but when I hung up I cried sore for me, for my husband and for our daughter.
CM, please don't put yourself down as we all grieve differently. I thought I was over the worst as Teddy passed December 6th, but this last week I have had the hardest time yet. Don't know why, it just happens. I believe that you and your daughter will draw strength from each other, you need to give it a little more time. How cold would we be i
Dear CM,
I haven't been on in a while but after reading your post I needed to. My husband lost his battle with cc on July 26th. Everything you wrote is exactly how I feel too. I am so sorry for your loss. For me driving in the car is the worst, i begin to cry and that's it, I just lose it! My two daughters are back in school, my youngest just started OSU in Semtember so, it's pretty quiet at my house now too. I will be keeping you in my prayers. The only thing that keeps me from completely falling apart is knowing that Jeff and I will be together again. Take care. -Jenny
Thanks Jenny- the 26th was our wedding anniversary.
Thank-you for posting, isn't it funny you are so far away and yet we are walking the same journey.
Dear CM and Jenny,
Ever since my daughter was diagnosed my world seem different. It seems like the whole cancer thing is on my mind 24/7. It is nice to have a place to come to where people feel the same. It makes you feel like you aren't crazy, but actually quite normal. I think people that aren't in our shoes as caregivers, patients, or family members can't understand what we really go through no matter how hard they try. We, here on this discussion board know exactly how another person feels as soon as we read their post. I sure find comfort in that. I wish you both happier days ahead.
What? Pam? Thank goodness you don't find us crazy! :)
It was this Board that got me through the 5 years of Teddy's battle and now it keeps me going after my loss. People like you and CM and so many others make me feel at times that this whole Board of people would do a fine job of running the world. Can you just imagine a world run by the kind and brave people on our site? I feel a verse coming on!
I asked for strength.
God gave me difficulties to make me strong.
I asked for wisdom.
God gave me problems to solve.
I asked for prosperity.
God gave me brawn and brain to work.
I asked for courage.
God gave me dangers to overcome.
I asked for patience.
God placed me in situations where I was forced to wait.
I asked for love.
God gave me troubled people to help.
I asked for favors.
God gave me opportunities.
I received nothing I wanted.
I received everything I needed.
Today is another first day of your life!
I absolutely, positively love you. You are the best!! You always make me laugh no matter how dark my day is. You truly are a gem. Thank you so much for being you and taking the time to brighten all of our days.
Love, Pam
Pam, its purely selfish as I truly get more than I give from all of you extraordinary people!
By the way I would like to say, before I forget.....I had my PET Scan last Friday for my own rare Cancer and it was stable! So I am starting my third year cancer free! Point is, I do practice what I preach and I can be preachy.
But thank you always for the nice compliments.
Great news Lainy! I am happy for you. If you don't mind me asking, what type of cancer do you have? I will pray for it to stay stable or get better. I would rather you got better!
Love, Pam
Thanks Pam. I am doing just fine. I had a GIST (Gastrol Intestinal Tumor) and had surgery 2 years ago this month. It is actually more rare than CC so Teddy and I used to laugh about that, like who has the rarest! I was so busy with him at the time that I didn't worry about myself and that attitude just remained with me. It was 10 cm but they got it all. At the same time they found a benign tumor on the other side of my intestine and removed that. I just have to follow up with 4 month visits to the ONC and 6 month PET Scans...for 3 more years. Oddly its another one that sneaks up on you and there is not much you can do except surgery. There is a chemo pill but my ONC felt I didn't need it. IF it returns it can met to other sites and organs. Honestly I don't think about it except for the scanxieties!
You are all awesome. Lainy, you particularly. I was having a hard day today but the posts on this forum helped enormously. Maybe a good day tomorrow and the strength for Petra's funeral the day after.
All of you are remarkable, Adam! I had told you not to be afraid of Petra's actual passing and now I am saying, do not be afraid of the Funeral. I tried not to think about Teddy's too much but it's hard not to when you are the one making all the plans. I did fine and it was everything he would have wanted it to be. I am Jewish he was Catholic and I had it at the Catholic Church. It was the first time ever that a Rabbi was on the alter and gave the Eulogy. Teddy was in both choirs so the Catholic Choir and the Jewish Choir sang. At the reception after, I had a microphone set up and everyone who wanted to could say what ever they wanted. IT WAS AWESOME. Teddy's sister is married to the lead tenor of The Four Lads, not sure if you know who they are, they have been around since the 50's. Anyway he got up and said Teddy was channeling through him and he sang "I Did It My Way". Then all Teddy's kids and Grandkids got up and in honor of his favorite time of year sang, "I'm Dreaming of a White Christmas". It was a time for fond Memories. I am sending my love and best wishes for you and your children to have a day that celebrates the wonderful wife and mother that was Petra!
Lainy, thanks for your advice. I'm right there with Adam...this really sucks. My dad is so lost right now. I'm a basket case, so I'm not real helpful. But I keep him out and about, since there is lots to do right now. I'm exhausted. It's only 8 here, and I'm ready for bed.
We spent lots of time looking through photos. I wanted to put some on the tables at the reception with the flowers. I thought that helped me quite a bit. I looked at all the pictures of my mom and said, "She really had a great life, perhaps too short, but she sure had fun." Then I realized I had 40 good years with my mom. A lot more than other people get the chance to have. Then today my dad and I went out, I saw women my moms age with their mothers and I couldn't take that.
Adam...I am sending you good thoughts for your and your children. I am so sorry you are having to go through this. She was much too young.
Adam and mn....my heart is with you both.
All my love,
MN, honestly you will be fine! You will be fine because you have to. I had forgotton but my daughter had made center pieces each was made in a triangle using see through pictures and in the middle of each set of 3 was a lit voltive candle. Lots of friends and family took pictures of Teddy home. I also had a beautiful picture of Teddy blown up and had that on an easel at the entrance to the Church then moved it to the reception hall and now its in his place of honor in the dining room. That way he is always with us, literally, for all the family dinners.
Yesterday was Petra's funeral. It was wonderful and horrible at the same time. The Church was packed, the hyms powerful and the minister cool. We couldn't affect a Jewish-Catholic rapprochement but it was a good atheist-Methodist-Anglican-Moslem thing.
The eulogy was by a guy who looked like me. In spirit, I was in a corner of the room distraught and in a heap, while my phsyical form stood up and spoke. People laughed. They said how great is was. I can't believe that it was me. Something took over. People said they recognised Petra in what I said. She was so funny. I don't think I will ever have fun like that again.
Adam, Petra is so proud of you as am I. Sounds to me like you had the United Nations there! You did it just as Petra would have wanted and that is absolutely a beautiful thing. Now you will begin to live your "new normal" however, Petra will never be far away. Life does go on just as Petra and Teddy would want it to. Love and hugs to you and the children!
Adam, Petra is smiling down on you and oh so proud of you. My thoughts and prayers are with you.
The information expressed is not medical advice. The discussion boards are not intended to replace the services of a trained health professional or to be a substitute for the medical advice of physicians or other healthcare providers. Read the full disclaimer.


text:
For the first time in Lewis Hamilton's Formula One career he has now taken the chequered flag for three consecutive races, even though the one in China caused confusion by being waved prematurely.
At the end of lap 55 of the 56-lap Chinese Grand Prix, a dominant Hamilton was shown the sport's traditional emblem as he crossed the line, and for a second he allowed himself to pause.
If the race had been as close as it was a fortnight ago when he beat Mercedes team-mate Nico Rosberg by exactly one second, such a lift off the gas could have proven extremely costly.
On this occasion, with an 18-second cushion to Rosberg, there was no cause for consternation, only a red face for the embarrassed flag bearer, understood to be mortified given his considerable experience.
Hamilton was quickly told by his team to complete the last lap, so taking the flag for a second time around 100 seconds later.
Under article 43.2 of the sporting regulations, however, the race has effectively been rewound by two laps, with the classification taken after lap 54.
The article reads: "Should for any reason the end of race signal be given before the leading car completes the scheduled number of laps, or the prescribed time has been completed, the race will be deemed to have finished when the leading car last crossed the line before the signal was given."
From his perspective inside the cockpit of his so far mercurial Mercedes, Hamilton said: "That was very strange!
"I thought: 'am I seeing things?' As I crossed the line expecting to do another lap, I looked up for a split second and I saw the flag.
"I lifted for a second, but I saw there was no-one on the wall (of the Mercedes pit who would be there to greet his win).
"I asked the team (whether the race had finished) and they said no, so I just kept going. Very, very strange.
"If I'd thought about slowing and the radio had failed, and then Nico came by, then that would have really sucked. Thank God it didn't."
Instead, Hamilton now has three successive wins to his name, and 25 in his career - with three of those in China - after leading from lights to flag.
Despite the string of wins, however, Hamilton still trails Rosberg by four points in the drivers' standings after the German again finished runner-up for the third consecutive time.
A technical failure in the season-opening race in Australia won by Rosberg is so far costing the Briton dear, but there was no doubting his delight at his latest success.
"I'm in the happiest mood I can remember being in," said Hamilton.
"I can't believe how amazing the car is, and with how hard everyone has worked; the results we are getting are because of that.
"It feels incredible to get three wins. I have to shout out a big thank you, thank you so much to the team, for embracing me into the team and for all the hard work and them continuously pushing forward.
"I'm so happy. I had such a great race, really enjoyed it, especially the last few laps.
"This team is on a roll, they've done a great job, but we're going to keep pushing, keep moving forwards and working hard because we know the others are going to keep pushing."
Not since 2005 and Renault has a team won the first four races of a season, with seemingly little threat being posed by their rivals.
Fernando Alonso lifted Ferrari on to the podium for the first time this season on Marco Mattiacci's debut as team principal.
Behind the Spaniard were the Red Bulls of Daniel Ricciardo and four-times champion Sebastian Vettel, who at one stage disobeyed an order to allow by his team-mate.
It had to be explained to Vettel the scenario as to why he should do so, with the 26-year-old German eventually relinquishing, finishing fifth to leave him trailing Rosberg by 46 points.
Vettel said: "I moved over for Daniel once I knew we were on different strategies.
"When I was first asked, I didn't understand as we were on the same tyre, unlike in Bahrain, so I double checked.
"When the team said we were on a different strategy I moved over and then, as the race went on, I saw more and more I didn't have the pace. There was no point in holding Dan back."
On a bad day for McLaren, Jenson Button could only manage 11th, with rookie team-mate Kevin Magnussen 13th, whilst Marussia's Max Chilton was 19th of the 20 finishers.


text:
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text:
Carrie Underwood Encourages Mike Fisher's Hockey Fights
Hockey fans will surely love Carrie Underwood's stance when it comes to her hubby, Nashville Predators centerman Mike Fisher and on-ice fights. While most hockey wives might discourage their significant others from engaging in a round of fisticuffs, Underwood is the exact opposite. She encourages Fisher to get in there and clean his opponent's clock, not because she advocates violence, but because she knows its par for the course and part of the game — and more importantly, that her husband can take care of himself.


text:
I always missed the sound of the '67--that lopey, uneven idle, and the whole front of the car shaking --Ken Woodcock
For many Corvette lovers, the sixth generation of America's Only True Sports Car is the best of both worlds--performance and style. But for some, when they get their first C6, there's something missing.
In the case of Ken Woodcock and the loaded '05 coupe he bought in 2009, that "something" had to do with the exhaust note. "When I brought it home, I told my wife--again--that I wasn't going to do anything to it, and she turned to me and said, 'You've got to do something with that sound--it just doesn't sound like a Corvette!'"
While this first-year C6 was loaded with every option except the RPO Z51 Performance Package, it lacked the sonic bravado of Woodcock's previous 427-powered '67 Sting Ray coupe. "I always missed that lopey, uneven idle, and the whole front of the car shaking," he recalls. "It was like nothing else."
Accordingly, the first thing Woodcock did to his '05 was an exhaust-system upgrade. "That's what a lot of people do--change the exhaust, so it sounds a little throatier, and has more rumble and a deeper tone to it," he says.
Then, when New Jersey Vette tuner East Coast Supercharging brought one of its cars to a Keystone State Corvette Club show (Woodcock is the club's president), the sound it made was music to his ears. "I said, 'That's the sound I want, right there!'" He contacted the guys at ECS, who had Comp Cams grind them a custom hydraulic roller camshaft, which they installed in Woodcock's LS2.
"It's a radical cam, but it's not to the point where it makes the car undriveable," he says. "[Driving it] is a little more work than a blower car, to be honest." He adds that with it, the LS2--which now puts out an estimated 511 horsepower at the crankshaft--likes to rev higher than before. "Sixth gear is all but useless. It doesn't like to live under 2,000 rpm."
Once the LS2 and its exhaust system delivered the sound that reminded Woodcock of his old big-block midyear, it was time to turn his attention to the chassis. "It came with everything that you could check off from the factory, including the (RPO F55) Magnetic Selective Ride Control," he notes. "You couldn't get that along with the Z51 Performance Package. So what I did was change the brakes, and the front and rear sway bars, to Z51 items.
"In essence, what I have is the best of both worlds," Woodcock adds. "I have the adjustable suspension, and I also have the Z51 sway bars and brakes, and it works out perfect."
When Woodcock had the '05 lowered, and added a set of Z06 wheels (blacked out with red pinstriping), he found that he'd revived the memory of his previous C2 in another way. As he recalls, "It wasn't until I got done with the project that my body guy, Larry Holcomb of Holcomb's in West Grove, Pennsylvania, said, 'You know what? I worked on your '67 before. Stand back and look at this car--you've done the same cues that were on your '67.' I stepped back and said, 'You're right!'"
Between the engine and chassis upgrades, the C5 is a blast to drive, according to Woodcock. "When you pull up to a red light, people look at you with this expression of 'Why is this even on the road?'" he says with a huge laugh. "You can see their jaws dropping and their eyes opening. I'm not talking kids--these are everyday, middle-aged older people who are shaking their heads because the car is sitting there, and the front end is shaking. It's just fun to drive."
If you're thinking of modifying or adding modern-tech upgrades to a Vette for show purposes, Woodcock recommends first deciding what class you want to show it in. "Once you start modifying a car, if you do too much to it, you'll be in a class where the competition is tough. If you're not willing to jump in with both feet, keep it stock and make the car as clean as you can. You'll have as much fun with that as the guys with the customs do."
Or as much fun as a long-time Vette owner whose C6 combines the best of all worlds--all in a 21st Century version of his C2.
|Spec Sheet
|'05 coupe
|Ken Woodcock; West Grove, Pennsylvania
|Stock LS2 aluminum
|364 ci
|Compression Ratio
|Stock LS2 aluminum
|Stock 2.00/1.55 with Comp Cams heavy-duty springs and titanium retainers
|Custom Comp Cams hydraulic roller with East Coast Supercharging (ECS) specs
|Rocker Arms
|Stock 1.7 ratio
|Stock hypereutectic aluminum
|Stock nodular iron
|Stock powdered metal
|Oil Pan
|Stock with Melling high-volume pump
|Intake Manifold
|Stock LS2 composite, ported and polished throttle body
|Fuel Injectors
|Fuel Pump
|Stock electric
|Stock coil-on-plug with MSD wires and NGK spark plugs
|Exhaust System
|American Racing Headers long-tube headers, high-flow cats, Borla "Stinger" mufflers
|Stock Tremec T56 six-speed manual with MGW short-throw shifter
|Z06 clutch/pressure plate
|Stock with RPO F55 Magnetic Selective Ride Control, Hardbar lowering bolts, and Z51 front/rear antisway bars
|Z51 rotors and powdercoated calipers
|Black Z06-style "Spyder" with red pinstriping
|Goodyear Eagle F1; 245/40R18 (front), 285/35R18 (rear)
|3,268 lbs
|Current Mileage
|Approximately 9,000


text:
Walden to begin Triple-A rehab assignment
ATLANTA -- Jordan Walden will begin a rehab assignment with Triple-A Gwinnett on Thursday night as he continues his recovery from a strained left hamstring.
The Braves would like the right-hander to make at least two appearances before they discuss his return to the Majors. Walden threw a pain-free bullpen session of 30 pitches at a high effort level on Tuesday, an outing that encouraged everyone involved.
"The first two were just kind of nice and easy," Walden said on Tuesday. "But today, I kind of did a little more."
Before Wednesday's game, Braves general manager Frank Wren indicated that Walden would soon begin a rehab assignment.
"He threw yesterday and threw great," Wren said.
Walden admitted when Atlanta placed him on the disabled list on May 10 that his hamstring had bothered him dating back to Spring Training. He decided to pitch through the pain, recording a 2.92 ERA, 19 strikeouts and six walks in 12 1/3 innings.
However, the discomfort became too much to bear when he gave up two earned runs in one inning against the Giants on May 4 at Turner Field. That outing snapped a streak of 10 consecutive scoreless appearances for Walden.
"I threw one more pitch and thank God I got out of the inning," Walden said on May 10. "That one kind of told me, 'It's had enough and I need to get it better.' I just need to make sure I get that better before I hurt my arm."
Mark Bowman is a reporter for MLB.com. Joe Morgan is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Center for Supply Chain Research™
Twenty-five years ago, The Pennsylvania State University recognized the need for a forum where industry leaders and academics could exchange ideas and advance knowledge in business logistics. In 1989, as the logistics profession was just gaining prominence, the Center for Logistics Research, renamed the Center for Supply Chain Research™, was founded to serve the needs of this growing community.
A look back . . . 25 years partnering with industry to further the study of supply chain management and address today's challenges in the field.
Today, the Center for Supply Chain Research™ (CSCR™) is member strong and intellectually active in many facets of supply chain management and the enabling technologies used for collaboration, visibility, and integration.
Although the Center is still firmly rooted in traditional aspects of supply chain transportation, distribution, and procurement — our research also penetrates emerging areas including topics on sustainability, low cost country sourcing, risk management, demand driven supply networks, and human behavior modeling.
Our mission is to offer the supply chain profession our very best in research, education programs, symposia, benchmarking, and workshops for executive management and leadership. It is also to support Penn State and the Smeal College of Business in achieving research and education excellence in supply chain and information systems while integrating the college into the broader business community.
Our strong academic and industrial community has made CSCR™ a leader in research, outreach, talent development and sponsorship.


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JORDAN Randerson is hoping to follow in the footsteps of a former teammate as he chases a professional deal in Samsung's Win a Pro Contract competition.
The 17-year-old, who lives in Pewsham and plays for Chippenham Park and Chippenham Town U18s, is one of the final 88 players in with a chance of winning a one-year contract at Swindon Town or Leyton Orient.
Full-back Randerson was inspired by former Corsham Town man George Nash, who reached the final three of the first ever Win a Pro Contract competition in January 2011.
Randerson, a student at Wiltshire College in Lackham, was due to take part in the latest stage of the national competition at Staines Town FC last Sunday but with the wet weather intervening, he will now showcase his talents in his 'quarter-final' trial on November 18.
"I used to play Futsal with George for Chippenham and he told me all about the competition and that I should give it a go," he said.
"He did really well to get to the final three and he's playing for England Universities now. I want to try to live up to his expectations.
"Being a professional footballer is a dream and I thought that I had to give it a try. I played for Wycombe Wanderers when I was about six or seven but I don't really remember it at all.
"Luckily, I was put straight through to the regional trials because of my football CV and was happy just to get that far.
"We had to go to Bristol and do loads of close control drills. The next one is a full 90-minute match and I've been picked at right-back.
"I was on my way there on Sunday when I got the phone call to say it was off and I was gutted but I've just got to get ready for a few weeks' time now."
The last 11 players in the competition will aim to impress Swindon manager Paolo Di Canio and Orient chief Russell Slade enough to earn a pro deal in December's final.


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Salted Caramel Sauce
Caramel sauce might be one of Hubby's favorite things ever. He will always choose a caramel treat over a a chocolatey treat. I've just recently gotten more comfortable making my own caramel sauce. It actually is so much easier than I thought it was. Having a candy thermometer is a must for making caramel at home. But that's really all you need. If you haven't made your own caramel sauce, do it. Trust me, it's worth the minimal effort required.
I ended up making a triple batch of this salted caramel during the holidays. I ordered some cute jars online and gave them away as gifts to some family members. Hubby also enjoyed a bunch of this caramel sauce heated up over vanilla ice cream.
One Year Ago: Crunchy Nut Encrusted Chicken Tenders
Two Years Ago: BBQ Chicken Pizza Sticks
Salted Caramel Sauce
Salted caramel sauce is easier to make than you could ever imagine. And it makes a great gift!
Yield: 2 cups
1 cup water
2 cups sugar
1 cup heavy cream
2 Tbsp cold unsalted butter
1 tsp fleur de sel
Add water to a 2-qt saucepan. Gently add the sugar to the center of the pot - it will mound, that's fine. Cover the pot and bring to a boil over high heat.
Once boiling, uncover the pot and insert a candy thermometer. Continue cooking until the mixture registers 300 F and is just starting to develop some color, about 15 minutes.
Reduce heat under the pot to medium and cook until the syrup is amber and registers 350 F on the thermometer, about another 5 minutes.
Meanwhile, pour the cream into a small saucepan and bring to a simmer. If it simmers before the syrup is ready, just take it off the heat and set aside.
Remove the caramel from the heat and add about 1/4 of the warm cream to the pot. It will bubble furiously so be careful. Once the bubbling subsides, add the remaining cream. When it stops bubbling, whisk gently to incorporate fully. Add the butter and the salt and whisk to combine.
Refrigerate up to 1 month.
Recipe from Cook's Illustrated, as seen on Erin's Food Files
4 Responses to "Salted Caramel Sauce"
After making vegan salted caramel ice cream, I'm in love with the stuff 🙂 If you're interested, I do have the recipe on my blog for vegan salted caramel, if you're interested in a non-dairy version!
i love caramel sauce! thanks for sharing!
This recipe was posted a week after I had my daughter so I didn't get around to making it until now. I decided to do this as a Christmas gift for a friend, and it took me 3 tries but I finally got it right, and it's delicious!!! Now that I know the tips and tricks to make it work, I can definitely see this being a good gift for future holidays/occasions.


text: I can't stop thinking about the lack of THansbrough in the pictures and inteviews. Was he even in attendance. Is the year the Ps as a team give up on Hans or has Hans given up on them. I hope I'm waaay out in west field, but I thought I saw some less than team spirit around Hans.


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How to Make a Positive, Long Lasting First Impression
Be Memorable in a Positive Way in Your Job Search
By Bob McIntosh,
Career Trainer
I don't remember much, but when I do, I never forget. There are some jobseekers I remember because they leave a lasting impression, like one woman I had in my Behavioral Interviewing workshop whose story about motivating others was so compelling. Melissa is her name.
Then there's Mark who just got an Administrator position in healthcare. He thanked me for my help and told me he'd write an account of his
search and how LinkedIn was of great help.
Lisa landed a benefits job in human resources. Previously she was a manager, but she wanted out of that. She proved that stepping down is fine, just as long as you can still prove your value.
Armando I remember because he would always ping me with updates about his job search. He was always positive, never seemingly desperate, and sometimes he offered to help me. He still remains one of my favorite former customers, still someone I'll reach out to. The other day, in fact, I called to see if he needed a gift in the form of a very talented jobseeker.
Unfortunately there have been people who are a complete downer, but they're far and in between. Still I remember them because of the poor impression they made. Mike Downer would constantly e-mail me about how he wasn't going to make it. I would tell him he would if he networked and tried to be positive. He finally got a job. I won't hear from him unless he needs another job.
The four people I mention–yes they exist–who came across as positive and/or were willing to provide any help they could are the ones I would go out of my way to help; whereas the one that was always negative is someone I'd dread hearing from.
There's a pattern here. People want to go out of their way to help those who make a good impression. If you want to be memorable to people who can assist you in your job search, keep in mind the following:
1. Appearing positive, regardless of your internal struggles, attracts more people than if you're negative. Negativity drives people away. Take Mike Downer, for example.
2. Remind people of you by pinging them with e-mails and phone calls, but don't annoy them with constant contact. Offer to meet them for coffee if it's convenient for them.
3. Always follow up after you've met someone who might be of assistance. Every time you follow up ask if you can be of assistance to them. If you can reciprocate in any way, it's better than only asking for their help.
4. Know your stories. Expert on storytelling,
Katharine Hansen @
A storied Career
, touts the importance of stories, how memorable they are in life and in the job search.
5. Let people know about your successes. Had a great
? Let people know. Finished a resume you're happy with? Let people know. Although your confidence may be low, announcing your achievements will make you and others feel great.
These are just a few positive things you can do to become memorable. Don't be a downer, regardless of your internal struggles. Most people understand that being out of work is painful, including yours truly; so don't make it the gist of your relationship with others. People like this are easy for me to remember, even if I can't remember big name actors like Chris….See, I forgot.
Read more
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. Find more
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About the Author
Bob McIntosh, CPRW
, is a career trainer at the Career Center of Lowell, where he leads more than 20 workshops on the career search. Bob is often the person jobseekers and staff go to for advice on the job search. As well, he critiques resumes and conducts mock interviews. One of his greatest accomplishments is starting a LinkedIn group, which is one of the largest of its kind in the state, and developing three in-high-demand workshops on LinkedIn. Bob's greatest pleasure is helping people find rewarding careers in a competitive job market. Please visit Bob's blog at
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6 Top Reasons to Avoid Being Stagnant at Work
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Making Sense of All the Recent Changes on LinkedIn
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From OpenWetWare
Boston University
BIOMOD 2013 Design Competition
Gel Electrophoresis
Gel Prep
For 1% Agarose Gel:
- 0.5g Agarose powder
- 5mL 5X Agarose Gel Buffer
- 45mL ddH2O
Add 500ul of MgCl2 and 5ul SybrSafe gel dye. Gently swirl the flask to mix contents and then pour the contents into a gel mold. Place the well comb in the mold and freeze for 20 minutes.
Gel Buffer
To prepare the buffer that fills the gel electrophoresis chamber, pour 30mL of the 5X buffer into a 500mL flask and dilute the total volume of the solution to 300mL. Set aside until the gel is solidified.
Sample Prep
Aliquot the desired volume of sample to be run in the gel, ensuring not to exceed the well capacity. Add loading dye and mix via pipetting.
Running the Gel
Place the gel in the electrophoresis chamber and fill the chamber with the gel buffer. Remove the comb and load the sample into the wells. Connect the electrodes and run the gel at the desired voltage for the desired length of time.
To prevent overheating of the gel, surround the gel electrophoresis chamber with ice.
TEM Prep
Select a TEM grid using specialized forceps and set the forceps with the grid down on a flat surface. Pipette 3uL of the desired sample onto the grid and let it sit for 2 minutes. Afterwards, wick away any excess moisture with filter paper. Next dip the TEM grid, sample side down, into a drop of uranyl acetate and hold for 30 seconds. Afterwards, wick away any excess moisture with filter paper. Lastly, dip the TEM grid, sample side down, into a drop of ddH2O and hold for 30 seconds. Afterwards wick away any excess moisture. Let the grid sit in the forceps on a flat surface for 1 minute until the surface of the grid is completely dry.
Measuring Concentrations via NanoDrop
Open the NanoDrop program and select Nucleic Acids. Blank the instrument with 2μL of the solution which the sample is suspended in. Wipe away any excess solution with a Kimwipe and then pipette 2μL of the sample onto the instrument and click "Measure." Repeat for as many samples as necessary. In between samples, rinse the instrument with 2μL ddH2O.
Purification via Dialysis Filters
During small scale experiments, 500μL 50kDa dialysis filters were used. The entire sample volume is pipetted into the filter and then the total volume is brought to 500μL with isolation buffer. The sample is spun in a centrifuge at 4000 RCF for 15 minutes. The staples are discarded and the volume of the filter is refilled to 500μL. The sample is spun again. This process is repeated for a maximum of 3 spins with a single filter. To retrieve the sample from the filter, the filter column is inverted and placed in a new tube. This tube is then spun at 2000 RF for 2 minutes.


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Baja Fish Tacos
As I mentioned the other day, Hubby and I love going to Dorado for our fish taco fix. While we were eating our tacos and elote, we were chatting about how we should try to make them at home sometime. I commented that the tortillas make a big difference.
I was apparently feeling bold that day because I just walked up to the counter and started up a conversation with the manager (which is so not like me!) I assumed they made their own tortillas, but in fact they buy them from a place just north of Boston. Then I asked if I could buy some from him. He gave me a whole bag for just a few bucks!! I was very excited and started planning out our meal on the walk home.
We decided to replicate our Dorado meal. I served these fish tacos with some delicious elote and black beans served over rice. We will definitely be having fish tacos at home more often!
One Year Ago: Lemon Blueberry Ice Cream Bars
Three Years Ago: Bruschetta
Baja Fish Tacos
Yield: 4
2 Tbsp taco seasoning
1 Tbsp fresh lime juice
1 Tbsp fresh orange juice
1 pound mahimahi or other firm whitefish fillets, cut into bite-sized pieces
1 Tbsp vegetable oil
2 cups presliced green cabbage
1/2 cup greek yogurt
1 avocado
salt and pepper to taste
8 (6-inch) corn tortillas
8 lime wedges
Combine first 3 ingredients in a medium bowl. Add fish; toss to coat.
Heat oil in a large nonstick skillet over medium-high heat. Add fish; sautê 5 minutes or until fish is done.
Combine yogurt and avocado in a medium bowl until chunky. Salt and pepper to taste.
Warm tortillas according to package directions. Spoon about 1/4 cup cabbage down center of each tortilla. Divide fish evenly among tortillas; fold in half. Serve with lime wedges.
Recipe adapted from Cooking Light
2 Responses to "Baja Fish Tacos"
Quality tortillas make all the difference! Good for you for asking about them. These fish tacos look delicious, and I'm definitely going to be trying them soon.
Lovely recipe! Love a good fish taco and this one looks like it wouldn't disappoint.


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Markets Slide; Dow Posts First Three-Day Losing Streak In 2013
Stocks ended in the red across the board for the second day in a row, with the Dow Jones Industrial Average falling more than 100 points to close below 15,000.
The Dow dropped 126.79 points, or 0.8% to 14,994.92. It lost ground on Monday as well, making this its longest losing streak of the year. The S&P 500 also lost 0.8%, falling 13.6 points to 1616.53; the Nasdaq, the only index to end in the black at all this week, on Monday, was off 36.52, 1.1%, to 3,400.43.
While investors were optimistic this morning, but the rally quickly lost steam, and markets were losing ground before noon. Asian markets fall and European markets also gave up early gains, closing down.
With sparse economic data out today, markets continue to fret over the possibility that the Federal Reserve and other central banks will begin to pull back their stimulus spending, which has been a boon to stocks. In addition, many analysts have been expecting more volatility after equities rose almost uninterrupted since the start of the year.
"While we believe this decline has further to go in time, and maybe even magnitude, we continue to look upon it as an uncomfortable metamorphosis from a liquidity led bull market to a fundamentally driven one that will ultimately lead to even higher highs before the year is out," writes S&P Capital IQ Chief Equity Strategist Sam Stovall . The firm recently increased its 12-month target for the S&P 500 to 1780 from 1670.
Monthly retail sales figures and jobless claims come out tomorrow, which should paint a clearer picture of the U.S. economy.


text:
Where the Boys are
House of Boys is basically Burlesque with men, Mohawks and leg-warmers (and without Cher) — an otherworldly allegory about humanizing the denizens of the gay subculture. As such, it's both depressing and titillating. It convincingly recreates the era's sexual openness, but also its dirty authenticity: Sex in the shower with a young punk may be hot, but you know the tub is moldy. (European films seem unnervingly comfortable portraying the murky reality of life — and Udo Kier in a gold bustier and blonde Marilyn wig is about as real and murky as life gets.)
For the entire review click here.
DEETS: Texas Theatre, 231 W. Jefferson Blvd. 9:20 p.m. 117 min. Not rated. Through Thursday. TheTexasTheatre.com.


text:
And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
Nature, meet industry. This dainty little number is not quite as dainty as it may seem. A delicate vines cascades down to what looks like a pearl, but is actually a polished concrete bead. And the artistry it takes to make that punctuating detail is nothing short of meticulous. The concrete bead is cast by hand, sanded and sealed to create a smooth finish. In our book, unexpected materials make minimalism all the more interesting.
This product ships from the maker within 10 days, via USPS
If you're not happy with this item for any reason, you may return it for a full refund within 14 days.


text:
Make a Holiday Customer Newsletter
Let your customers know what's coming up in the year ahead with a festive newsletter.
Instructions: Browse to find the brochure template.
Instructions: Compose your copy announcing upcoming events or a special offer and add to the template on the outside and inside of the brochure. Insert photos to accompany your copy and import your company logo.
Instructions: Print on Avery Matte Coated Brochures, fold and seal with an Avery seal, included in the package.
Instructions: Browse to find an address label template.
Instructions: Type in your customers' names and addresses. Print on Avery Mailing Labels and apply to the mailing panel of the brochure. Send to your customers and watch the new business roll in.


text:
Did you know...
The U.S. Census gathers a wide range of statistics that tell us how Americans live, work and study. This information can be useful not only to businesspeople and politicians, but to the average citizen simply interested in learning more about their community.
My Congressional District, a new interactive tool using the most up-to-date data from the American Community Survey, makes it easier to find basic demographic information as well as statistics on education, finance, jobs, and housing for every congressional district in the U.S. Users can quickly isolate the information they need and share it on Facebook or Twitter, download it to their computers, or embed it on their personal webpages. To use the tool, just select your state and district number (map provided if you're unsure) and click on an icon to view a list of statistics.
Navigating the Census Bureau website can be overwhelming if you're not used to sifting through census data. My Congressional District gathers all of that information and makes it available in one easy-to-use tool.
Find this article at


text:
- Availability:
- In Stock
- Product Code:
- Nano Tec Z-Speed
- Brand:
- Flex Power
Available Product PromotionsPeace Sale 10% Discount --OR-- Combo - Buy 2 Rackets at 20% Discount Get 20% off on all bags with this racket
Available Options
The Flex Power Nano Tec Z-Speed racket has a very similar looks as the Yonex NanoRay Z-Speed badminton racket.
- Flex Power Nano Tec Z-Speed is designed to give you sharper smashes and at the same time let you enjoy the precise drop shot and netting play.
- The racket was developed with the new "Whip-Slim Frame" which increased the Speed in the swing, and overall improve execution with Power and more Control.
- With its light body and slight head heavy design, enable you to move the racket like a sword and to deliver a very clean and sharp execution.
- The racket is a medium flex racket that will deliver both power and control, as it use the sling shot effect to generate power and transfer movement more effectively from the arm to the shuttle to increase control.
- The Flex Power Nano Tec Z-Speed is an extremely fast racket and is developed to suit power based players who want more control or those seeking to improve power generation.
- This racket is very well balanced and awesome to play with, and with the price over performance, it gives you the best value for money.
|Flex Power Nano Tec Z-Speed Specifications
|Frame Material:
|Hi Modulus Graphite + Whip-Slim Frame
|Shaft Material:
|Hi Modulus Graphite + Carbon Nanotube
|84g +/- 2 (4U-G1)
|Max Tension:
|295mm +/- 3 (Slight Head Heavy)
|Orange / Black
|Special Features
|Isomectric head frame
|Equalizes the length of main and cross strings in the stringbed, enlarging the sweet-spot for more consistent accuracy even on off-center hits.
|76 Grommets system
|This single-pass grommet holes construction provides more grommet holes, creating a high-performance stringing pattern that puts 7% more durability.
|Carbon Nanotube
The Carbon Nanotube is adopted in both sides of the frame in order to give strength and perseverance. It holds large amount of energy at the impact, and releases it back like an arrow. It gives you depth and control in your game.
|Whip-Slim Frame
|The Whip-Slim Frame provides smaller flat surface compared with an ordinary racket for better speed, fast swing-through and the quicker maneuverability.
|Reinforced Structure Frame
|The new material is adopted in the frame in order to make the frame Ultra high Strength & Stiffness. As a result it can handle string tension of up to 35lbs.
|Racket Specifications
|Hi Modulus Graphite + Whip-Slim Frame
|Hi Modulus Graphite + Carbon Nanotube
|84g +/- 2 (4U-G1)
|Max Tension
|675mm +/- 2
|Balance Point
|295mm +/- 3
|76 Holes
|Orange / Black
|Special Features
|Isomectric head frame; 76 Grommets system; Carbon Nanotube; Whip-Slim Frame; Reinforced Structure Frame;


text:
If you're so unhappy with your job that you plan to look for a new position this year, you're not alone.
A recent Monster survey finds that 81 percent of workers who have used their Monster account in the past three years plan actively to seek another job this year, and 79 percent report they're confident they're going to land another position.
A desire for more money is a motivating factor for many workers, according to the online survey of nearly 6,000 job seekers. But so is a desire for a more personally fulfilling position.


text:
A Long-term Follow-up of the HIV-NAT Cohort
This study is currently recruiting participants.
Verified February 2017 by The HIV Netherlands Australia Thailand Research Collaboration
The HIV Netherlands Australia Thailand Research Collaboration
Information provided by (Responsible Party):
The HIV Netherlands Australia Thailand Research Collaboration
ClinicalTrials.gov Identifier:
First received: December 14, 2006
Last updated: February 22, 2017
Last verified: February 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Biospecimen Retention: Samples With DNA
Detailed Description:
With HIV/AIDS increasingly considered a chronic disease, 24-, or 48-week data from antiretroviral studies are no longer sufficient. Only with long-term follow-up and outcome data will shed some much-needed light on the answers of questions that have stumped us for several years. Data from a large observational cohort of patients treated with combination antiretroviral therapy will provide further insights into the long-term safety and durability of various antiretroviral therapeutic approached, the efficacy of HIV viral load and CD4 cell counts as predictors of disease progression and mortality, and the importance of adherence.
|HIV Infections
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|A Long-term Follow-up Study for HIV-infected Individuals Who Have Participated in HIV-NAT Study Protocols
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDSU.S. FDA Resources
Further study details as provided by The HIV Netherlands Australia Thailand Research Collaboration:
Primary Outcome Measures:
- HIV infection [ Time Frame: 30 years ]
This cohort will collect various information such as but not limited to:
comorbidity, mortality, cardiovascular, neurological clinical data, treatment history, serious adverse events, PBMCs, clinical outcomes, virological outcomes, resistance, failure, aging, other opportunistic infections, etc
Biospecimen Retention: Samples With DNA
PBMC collection once a year
|Estimated Enrollment:
|Study Start Date:
|November 2002
|Estimated Study Completion Date:
|December 2020
|Estimated Primary Completion Date:
|December 2020 (Final data collection date for primary outcome measure)
Primary Objective:
To collect and evaluate long-term clinical outcomes of HIV infected participants previously enrolled in HIV-NAT trials.
Secondary Objective:
To Assess:
- Long-term consequences of initiation of antiretroviral as predicted by baseline CD4 cell count and/or baseline plasma HIV RNA level
- Incidence of lipodystrophy and other metabolic complications in three different groups of patients initially treated with NRTI-based regimens, NNRTI-based regimens, or PI-based regimens
- Class-specific incidence of lipodystrophy and metabolic complications such as d4T versus AZT, nevirapine versus efavirenz and individual PIs (IDV, SQV, Kaletra, and atazanavir)
- Resistance profiles in patients on different antiretroviral regimens
- Long-term consequences of antiretroviral agents on cardiovascular, renal, hepatic, and endocrine function, skin, gastrointestinal system and urogentital tract
- Incidence of opportunistic infections or malignancy including hepatocarcinoma in patients with HIV/HCV or HIV/HBV co-infection
- Immune recovery syndrome
- Adherence to different antiretroviral regimens
- Quality of life
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
All HIV infected adult patients from HIV-NAT.
Inclusion Criteria:
- HIV infected patients( children and adults) previously participated HIV-NAT studies
- HIV infected patients( children and adults) currently participate in HIV-NAT trials
- Able to provide written consent
Exclusion Criteria:
- Unable to provide written consent
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00411983
Please refer to this study by its ClinicalTrials.gov identifier: NCT00411983
|Contact: Anchalee Avihingsanon, MD, PhD
|66 2 2557334-5 ext 107
|Contact: Stephen Kerr, PhD
|66 2 2557334-5 ext 138
|HIV-NAT, Thai Red Cross AIDS Research Center
|Bangkok, Thailand, 10330
|Principal Investigator: Praphan Phanuphak, MD, PhD
Sponsors and Collaborators
The HIV Netherlands Australia Thailand Research Collaboration
|Principal Investigator:
|Praphan Phanuphak, MD, PhD
|HIV-NAT, Thai Red Cross AIDS Research Center
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by The HIV Netherlands Australia Thailand Research Collaboration:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
Additional Information:
Law WP, Duncombe CJ, Mahanontharit A, Boyd MA, Ruxrungtham K, Lange JM, Phanuphak P, Cooper DA, Dore GJ. Impact of viral hepatitis co-infection on response to antiretroviral therapy and HIV disease progression in the HIV-NAT cohort. AIDS. 2004 May 21;18(8):1169-77.
Law WP, Dore GJ, Duncombe CJ, Mahanontharit A, Boyd MA, Ruxrungtham K, Lange JM, Phanuphak P, Cooper DA. Risk of severe hepatotoxicity associated with antiretroviral therapy in the HIV-NAT Cohort, Thailand, 1996-2001. AIDS. 2003 Oct 17;17(15):2191-9.
Avihingsanon A, Kerr SJ, Punyawudho B, van der Lugt J, Gorowara M, Ananworanich J, Lange JM, Cooper DA, Phanuphak P, Burger DM, Ruxrungtham K. Short communication: Aging not gender is associated with high atazanavir plasma concentrations in Asian HIV-infected patients. AIDS Res Hum Retroviruses. 2013 Dec;29(12):1541-6. doi: 10.1089/aid.2013.0069. Epub 2013 Oct 2.
Clarke A, Kerr S, Honeybrook A, Cooper DA, Avihingsanon A, Duncombe C, Phanuphak P, Ruxrungtham K, Ananworanich J, Kaldor J. Adherence and Risk Behaviour in Patients with HIV Infection Receiving Antiretroviral Therapy in Bangkok. Open Virol J. 2012;6:23-8. doi: 10.2174/1874357901206010023. Epub 2012 Feb 24.
Nuesch R, Srasuebkul P, Ananworanich J, Ruxrungtham K, Phanuphak P, Duncombe C; HIV-NAT Study Team. Monitoring the toxicity of antiretroviral therapy in resource limited settings: a prospective clinical trial cohort in Thailand. J Antimicrob Chemother. 2006 Sep;58(3):637-44.
Avihingsanon A, Tongkobpetch S, Kerr SJ, Punyawudho B, Suphapeetiporn K, Gorowara M, Ruxrungtham K, Shotelersuk V. Pharmacogenetic testing can identify patients taking atazanavir at risk for hyperbilirubinemia. J Acquir Immune Defic Syndr. 2015 May 1;69(1):e36-7. doi: 10.1097/QAI.0000000000000540.
Kerr SJ, Punyawudho B, Thammajaruk N, Colbers A, Chaiyahong P, Phonphithak S, Sapsirisavat V, Ruxrungtham K, Burger DM, Avihingsanon A. Factors associated with daily tenofovir exposure in Thai subjects taking combination antiretroviral therapy. AIDS Res Hum Retroviruses. 2015 Apr;31(4):368-74. doi: 10.1089/AID.2014.0249. Epub 2014 Dec 17.
Avihingsanon A, Ramautarsing RA, Suwanpimolkul G, Chetchotisakd P, Bowonwatanuwong C, Jirajariyavej S, Kantipong P, Tantipong H, Ohata JP, Suankratay C, Ruxrungtham K, Burger DM. Ergotism in Thailand caused by increased access to antiretroviral drugs: a global warning. Top Antivir Med. 2014 Jan;21(5):165-8.
Avihingsanon A, Jitmitraparp S, Tangkijvanich P, Ramautarsing RA, Apornpong T, Jirajariyavej S, Putcharoen O, Treeprasertsuk S, Akkarathamrongsin S, Poovorawan Y, Matthews GV, Lange JM, Ruxrungtham K; HIV-NAT125 study team. Advanced liver fibrosis by transient elastography, fibrosis 4, and alanine aminotransferase/platelet ratio index among Asian hepatitis C with and without human immunodeficiency virus infection: role of vitamin D levels. J Gastroenterol Hepatol. 2014 Sep;29(9):1706-14. doi: 10.1111/jgh.12613.
Wattanakul T, Avihingsanon A, Manosuthi W, Punyawudho B. Population pharmacokinetics of nevirapine in Thai HIV-infected patients. Antivir Ther. 2014;19(7):651-60. doi: 10.3851/IMP2741. Epub 2014 Feb 6.
Durier N, Ananworanich J, Apornpong T, Ubolyam S, Kerr SJ, Mahanontharit A, Ferradini L, Ruxrungtham K, Avihingsanon A. Cytomegalovirus viremia in Thai HIV-infected patients on antiretroviral therapy: prevalence and associated mortality. Clin Infect Dis. 2013 Jul;57(1):147-55. doi: 10.1093/cid/cit173. Epub 2013 Mar 19.
Praditpornsilpa K, Avihingsanon A, Chaiwatanarat T, Chaiyahong P, Wongsabut J, Ubolyam S, Chulakadabba A, Avihingsanon Y, Ruxrungtham K, Tunsanga K, Eiam-Ong S, Phanuphak P. Comparisons between validated estimated glomerular filtration rate equations and isotopic glomerular filtration rate in HIV patients. AIDS. 2012 Sep 10;26(14):1781-8. doi: 10.1097/QAD.0b013e328356480d. Erratum in: AIDS. 2013 Mar 13;27(5):853.
Kerr SJ, Duncombe C, Avihingsanon A, Ananworanich J, Boyd M, Sopa B, Medtech B, Chuenyam T, Cooper DA, Lange JM, Phanuphak P, Ruxrungtham K. Dyslipidemia in an Asian population after treatment for two years with protease inhibitor-containing regimens. J Int Assoc Physicians AIDS Care (Chic). 2007 Mar;6(1):36-46.
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|The HIV Netherlands Australia Thailand Research Collaboration
|ClinicalTrials.gov Identifier:
|NCT00411983 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 14, 2006
|Last Updated:
|February 22, 2017
Keywords provided by The HIV Netherlands Australia Thailand Research Collaboration:
chronic HIV infection
long term cohort of HIV infection
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
ClinicalTrials.gov processed this record on September 25, 2017


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DEARBORN, Mich. - A Dearborn woman recently looked out her window and saw what she believed to be a miniature kangaroo hopping around her yard. Turns out it was no kangaroo, but a 1-year-old Chihuahua with severely malformed front legs. The pup, named Victory, had no paws and was forced to walk on her hind legs. Victory was taken in by the Friends for the Dearborn Animal Shelter where doctors have determined not much can be done for her surgically.
---Victory the miniature Chihuahua
Doctors at Michigan Veterinary Specialists say the gutsy girl will need a specially designed mobility cart and other orthopedic equipment to maximize her quality of life.
You can help with medical bills by making a Hope's Hero donation . The money will also be used to cover future equipment costs. Read more about Hope's Hero program to benefit special rescues in need.
You may also like:
Disabled piglet learning to use wheelchair becomes internet sensation
A disabled piglet is melting hearts across the web. The pig, named Chris P. Bacon, was born without the use of his back legs.
A video of Bacon trying out his homemade wheelchair, made out of toy parts, was posted on YouTube by Dr. Len Lucero.
Images of the 10-day-old piglet soon gained a devoted following online. Bacon even has a Facebook page, under the name Chris P Bacon Pig on Wheels.18550744
Copyright 2013 by ClickOnDetroit.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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- Architectural Studies Center
- Center for Athletics and Wellness
- Day Care Center
- Emmanuel Hall
- Healthy Families Center
- Immaculata Hall
- Liberal Arts Center
- Loughran Hall
- Madonna Hall
- Maintenance Buildings
- Maria Hall
- McCarty Hall
- McGowan Center
- Memorial Arch
- Nazareth Student Center
- Performing Arts Center
- Perpetual Help Hall
- Printing and Mailing Center
- Regina Hall
- Rotunda
- Science Center
- Student Life Center
- Studio Arts Center
- Swartz Center for Spiritual Life
- Veterans Resource Center
- Visual Arts Center
- Woodland Residences
GPS Coords: N 41.433165 W 75.636533
Regina Hall is a residence hall with primarly double occupancy rooms. A community lounge, kitchenettes, and quiet study areas are located throughout the building. The second floor boasts a large lounge with a TV, fireplace, and plenty of comfortable furniture.
The Liguori Center, located on the first floor, is used for conferences and receptions.


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HD - Denali Landscape
HD - Denali Rain 00470B
Rainfall over the Denali Wilderness. High Definition footage available in everything from 480(i&p) to 1080(i&p).
Length: 14 sec (additional lengths available)
Shot speed: real
Digital file
Purchase: This video is rights-managed, please
contact Kennan Ward Photography with details
of your anticipated use by calling 831-459-8800 or emailing Kennan Ward at firstname.lastname@example.com.
Have a Mac and you're having trouble viewing the video?
(Do you have a Q with ? instead of streaming video?)
Try this fix: Go into the Macintosh HD, then Library, then Internet Plug-Ins.
Remove Quicktime Plugin.webplugin.


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The State System of Higher Education (SSHE) adopted a policy stating that all university programs shall be evaluated at least once every five years (Attachment 1). When deemed appropriate, the university president or his/her designee may require a shorter review interval. (It is the intent for such interim reviews to address the period of time since the previous program review was completed.)
In order to simplify the program review process as well as to make it more meaningful to individual schools/departments/units, there have been a number of key changes that have been made to the process per the Provost as of December 2011:
- The program review will address questions in three required areas of focus: Curriculum, Student Success, and Integrated Planning. selected areas of focus may include: Faculty Accomplishments, Pedagogy, and Other (to be identified by the department and approved by the Dean).
- A standard program data packet (Attachment 3) will be compiled by the staff of the Office of Institutional Research – for academic program reviews only.
- A final report will not exceed fifteen (15) pages of narrative.
- With the approval of the Provost, accreditation reviews may be integrated with the program review process, even replacing the program review, but it may be necessary to expand the accreditation review to insure meeting all program review requirements.
- Academic and academic- and student-support unit program reviews must complete the State System Summary Form (Attachment 9).


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1994 Starcraft Camping Trailer Prices and Specs
Select a Year and Model
(2017 - 1966)
Camping Trailers
Starcraft has a rich manufacturing history dating back to 1903 as a producer of farm equipment and later boats. Entering the recreational vehicle marketplace in 1964, Starcraft began producing a folding camping trailer. Eventually, Starcraft added truck camper, fifth wheel and travel trailers to their line-up providing a wide assortment of mobile vacation products. Built in North Indiana, Starcraft recreational vehicles are constructed with proven production processes.


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1. Neil Young at the Scotiabank Saddledome (Tuesday, Nov. 13)
The legendary Neil Young brings Crazy Horse to the 'Dome. There are tickets still available, but probably not at the lower end of the spectrum.
2. Will Ferguson at John Dutton Theatre, W.R. Castell Central Library (Tuesday, Nov. 13)
Will Ferguson recently won the Giller Prize for his thriller, 419. Celebrate the achievements of this local author with a reading presented by WordFest.
3. Metric and Stars at Stampede Corral (Wednesday, Nov. 14)
A great double-header of CanCon in the barn of the Corral. Both bands are supporting new albums: Stars is touring for The North and Metric is supporting Synthetica.
4. Me Talking to Myself in the Future at Theatre Junction Grand (Wednesday, Nov. 14 to Saturday, Nov. 17)
Marie Brassard was inspired by her childhood for the play Me Talking to Myself in the Future as she tells J. Paul Halferty in this interview. Theatre Junction presents her work, which is a solo performance and a surreal self-portrait. (Edit: Apparently the Halferty interview link isn't working for some people, so here's an interview the Calgary Herald's Stephen Hunt did with Brassard from Tuesday's newspaper.)
5. Soundasaurus at the Engineered Air Theatre, Epcor Centre (Thursday, Nov. 15 to Saturday, Nov. 17)
It's the fourth year for this festival of experimental sound, media, performance and visual arts. You may hear some strange things, but it will definitely be aurally fascinating.
Honourable mentions: Gwar play MacHall on Thursday; expect a lot of fake blood and costumes. —Jon Roe


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Restored Church Mormon - Wings Mug
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Your own personalized Mug Restored Church Mormon - Wings ensure that your morning coffee, or tee, or chocolate milk, tastes better. The ceramic ensure long durability and give your morning breakfast a sophisticated air, which will also keep your beverage hot longer.
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AN 4.28 wrote:
...These are the four traditions of the Noble Ones — original, long-standing, traditional, ancient, unadulterated, unadulterated from the beginning — which are not open to suspicion, will never be open to suspicion, and are unfaulted by knowledgeable contemplatives and priests.
The source for the "lineage of the Noble Ones" comes from a commentary; the Buddha's father is upset that his son is begging, and remarks that no person of Sakyan lineage has ever gone begging. To this, the Buddha (allegedly) responds with the "lineage of the Noble Ones" line.


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FAQs: Street Addressing
Chapter 102 of the Code of Fairfax County.
No. The law has specific requirements for how an address is assigned.
See Street
Addressing for more information.
Yes. The law requires numbers to be affixed to the primary structure on
the property.
The ability for public safety personnel to quickly find an address
during an emergency is the key factor to the street addressing law. The
law was written to save lives, preserve property and aid the general
welfare of the residents, workers and visitors of Fairfax County.
See Street
Addressing or contact the Fairfax County Addressing Office via e-mail or at


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Nearly three in four doctors and nurses (72 percent) take supplements, according to the Healthcare Professionals Impact Study, which surveyed about 1,200 primary care physicians, obstetrician/gynecologists, physician specialists, and nurses and nurse practitioners. Among health care professionals who use supplements, 87 percent take a multi-vitamin, 78 percent take vitamin C, 63 percent take B vitamins, 59 percent take vitamin D, 58 percent take vitamin E and 58 percent take calcium. The survey also found nearly four in five doctors (79 percent) recommend supplements to their patients. The five top reasons doctors recommend supplements are: overall health and well-being, bones, joints, heart and cholesterol.
Doctors know the brain needs vitamins and minerals to work well and in one study, wanted to see if a daily supplement improved mental ability in children. Over 12 weeks, 81 healthy kids, aged 8 to 14, without food allergies, took a daily multi-vitamin and mineral supplement or a placebo. On the first and last days of the study, one hour before the daily dose and one and three hours afterward, researchers measured the speed and accuracy of attention and tested memory and mood. They found that attention improved in the multi-vitamin / mineral group three hours after the first dose on the first day. Study authors remarked, "The most surprising facet of the improvement in attention task performance seen here is that it became evident by three hours post-dose on the first day." Researchers noted that this is the first study to test if supplements have an immediate effect on behavior.
Reference: British Journal of Nutrition; 2008, Vol. 100, No. 5, 1086-96.


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Headwinds Are Building
For weeks I have been writing that rather than try to anticipate a market top, we should wait for some weak price action before becoming more bearish. Today, we finally saw some poor action for the first time this year. There wasn't a major point loss, but the S&P 500 and the Russell 2000 suffered their largest pullbacks of 2013 and the market closed very poorly after a gap-up open.
My message for a while now has been that we shouldn't be anticipatory but rather we should react quickly when there is some actual change in conditions. Today things did change and that means we need to adopt a higher level of caution....157 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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On bright days when the Clinch River in southwestern Virginia runs clear, you can see signs of rebirth strewn along its rocky bottom like so many black pearls. Braven Beaty, an aquatic ecologist in rubber waders, pokes an arm into the mountain stream's icy swirl and pulls out a hopeful omen.
"Black sandshell," he calls out, rotating a small mussel between fingertips. "A threatened species. I've never seen one this far north."
The scientist returns the mussel to its place and scoops up another, and then another, reciting the names of the species as he finds them: fine-rayed pigtoe; kidneyshell; rough rabbitsfoot. In half an hour, he finds 12 different species in a spot no bigger than a carport.
The variety is striking, even for a stream that boasts more varieties of freshwater mussels than any waterway on Earth. But equally striking are the absences: Once there were as many as 60 types of mussels in this Appalachian river before pollution and silt from a century of logging and coal mining wiped out a third of them—forever.
The Clinch's mussels are slowly coming back, but so far recovery is limited to areas protected by a fragile alliance of conservationists and property owners working to keep sediments out of the water. "It's hard to get people to understand why mussels are important," says Beaty. "It's even harder to go to landowners and say, 'You're part of the problem.'"
Drawing a connection between land and water is crucial, not only for the Clinch but also for hundreds of other waterways around the country. In an era when environmental regulations have stemmed the flow of pollutants from many U.S. factories, rivers are straining under a burden of chemicals and silt from thousands of smaller sources—everything from poorly managed logging projects and animal waste from factory farms to motor oil off parking lots and weed killers from suburban lawns.
Such diffuse, or nonpoint, pollution is now the Number One cause of contamination in American waterways, fouling an estimated 1.3 million miles of streams and rivers. It is the main reason nearly 40 percent of the nation's lakes, rivers and estuaries still are not clean enough for swimming or fishing, according to a 1997 Environmental Protection Agency (EPA) analysis.
"The magnitude of the problem just hasn't been recognized," says Michael Murray, an NWF environmental chemist and staff scientist, "and as a result we're seeing nonpoint pollution getting even worse in a lot of areas of the country." The situation, he adds, is compounded in many areas by air pollution, which contaminates waterways with dioxins and other chemicals emanating from distant sources.
An NWF study released last spring reported that states simply are not enforcing the law when it comes to preventing diffuse pollution from washing into streams (see below). "The failure is inexcusable and the problems are preventable," concludes the report. "The tools for cleaning up polluted runoff and contaminated rain are there, but most states simply aren't using them aggressively enough."
For states, the primary legal weapon against nonpoint pollution is called the Total Maximum Daily Load (TMDL) restoration program. Created with the passage of the federal Clean Water Act in 1972, the TMDL provision requires regulators to consider all sources of pollution across a river's watershed, or drainage basin.
A watershed is the area of land from which rain or melting snow drains into a river. It can be as small as a few hundred acres—typical of a small stream—or it can encompass thousands of square miles and several states, as in the case of the Mississippi River. In all watersheds, the rainwater that replenishes the river also brings wastes that can damage it. Unless preventive steps are taken, pollutants can be swept up in storm runoff and deposited in the river itself.
A TMDL plan helps states identify these hidden problems. The program starts with careful monitoring of water quality by state regulators, along with an investigation of where the pollutants are coming from. Next, the states set limits for each type of pollution—the "total maximum daily load" a river can safely carry. When a river exceeds the limit for a chemical, the state crafts a pollution-reduction strategy that divides the cuts among both point and nonpoint sources of the chemical. States have discretion in determining how the actual allocations are made, with the only requirement that the reductions result in attainment of water-quality standards.
"This TMDL approach makes a clean-up effort more effective and fairer to all parties," says Murray. It can also yield surprising insights: In the Christina River Basin near Wilmington, Delaware, for example, officials discovered that farming and suburban sprawl had eclipsed the state's homegrown chemical industry as the leading source of the river's problems. Runoff from farms, lawns and parking lots alone destroyed or damaged fish habitats in nearly 40 percent of the river's tributaries, according to a TMDL investigation.
More than two-thirds of the nation's state governments still lack a workable TMDL program, NWF found. "Not one of the 50 states has done what the law requires," it said. The result: Despite a public perception of steadily cleaner rivers and lakes, progress has stalled in many areas and has actually reversed in others. Some examples:
Fertilizers and animal waste from factory livestock farms have helped trigger an unprecedented number of algal blooms, destructive growth spurts that clog waterways and suffocate fish. Most notorious were outbreaks of toxic algae, including the organism Pfiesteria piscicida, blamed for killing a billion fish in coastal North Carolina.
Increased monitoring and continued mercury contamination in lakes and rivers has led to a doubling of fish-consumption advisories (warnings against consuming certain fish) from 1993 to 1998. Much of the mercury originates as smokestack emissions and falls to Earth with rain and snow.
Farm chemicals from states in the Midwest have flowed down the Mississippi River, helping feed a growing "dead zone" of barren, oxygen-depleted water in the Gulf of Mexico. The size of the dead zone ballooned in the early 1990s and grew to 7,500 square miles before shrinking last summer due to drought in the plains states.
Even where the problems are not so dramatic, chemicals in polluted runoff have created the equivalent of a low-grade toxic-waste spill that now extends to virtually every river and stream in the country. In a landmark survey completed in 1999, the U.S. Geological Survey (USGS) found at least one pesticide in almost every water and fish sample it collected. In fact, more than half the streams tested in the agency's National Water Quality Assessment Program contained at least five pesticides. The levels of these individual contaminants were usually within EPA safety limits, but the combinations and ubiquity of the chemicals raised a troubling question: Do chronic, low doses of multiple pesticides add up to a greater risk for wildlife and people? "We simply don't know the effects of sustained exposure to mixtures of chemicals on an aquatic ecosystem," says USGS scientist Bob Gilliom.
The seesaw fortunes of the Clinch River's mussels are a case study in how changes on land can impact river species and throw entire ecosystems out of balance. Geology and geography conspired to make the waterway one of the world's great habitats for mussels. Over time, the creatures became the biological cornerstone for a large and diverse wildlife community in and around the Clinch that includes more than 400 rare plants, animals and insects.
However, for an animal that lives in a rock-hard vault and can survive up to 60 years, the mussel is extraordinarily delicate. "Mussels were once 20 percent of the river's entire biomass," notes Beaty, who conducts research for The Nature Conservancy.
By the late 1980s, the number of mussel species in the Clinch had dropped from 60 to 40, with 26 of the remaining species now facing a serious threat of extinction, scientists say. "The mussels are the piece of the puzzle that disappears first when things start to go wrong," Beaty says. "The good news is, if it's early enough, even if you lose some of the species, there's still a chance you can save the ecosystem."
Undoing the damage caused by nonpoint pollution is never as easy as closing a factory or turning a faucet. The modest recovery of the Clinch River and its mussels is the result of a decade of work by dozens of groups to neutralize, one by one, the many small problems that caused the river's water quality to worsen in the first place. Farmers in the area, for instance, with financial assistance from government agencies, have begun fencing in their pastures to keep livestock out of streams. The same sort of slow-but-sure approach is working to help prevent runoff in rivers elsewhere.
In Boston, federal and local leaders have seen a turnaround in the polluted Charles River in the past five years, through the use of TMDL plans and a crackdown on communities with outdated stormwater systems. The Charles is one of the nation's most heavily used recreational rivers. Yet in 1995, authorities rated it too dirty for swimming 81 percent of the time.
An aggressive cleanup effort launched that same year took aim at illegal sewage hookups and storm runoff from more than 30 towns along the river's banks. A study of the Charles, initiated in 1994 by the Charles River Watershed Association (CRWA), proved conclusively that point-source pollution remained a serious problem in the river. As a result, the EPA ordered local governments to begin a comprehensive search for pollution sources, which discovered hundreds of them. "Over the years, with municipal budgets stretched, it's been easy to allow funds for sewer and storm-drain maintenance to disappear," says CRWA Executive Director Bob Zimmerman.
The payoff for such efforts came last summer, when the Charles fell short of federal swimming standards only 35 percent of the time and earned an above-average rating from the EPA. "Removal of point sources has made a difference," says Zimmerman. "Getting the river clean the rest of the way, however, is likely to be more difficult."
In northwestern Montana, residents along tiny Elk Creek were moved to action after the stream's renowned cutthroat trout began disappearing. The problem: The fish's spawning and feeding grounds were seriously damaged by runoff from nearby development and streambed erosion.
The Elk's fast waters run through mountain gorges and valleys that traditionally were blanketed with a dense covering of evergreens. The trees provided shade, organic matter and shelter for trout, whose size and numbers were legendary. But by the mid-1990s, developers, farmers and loggers had stripped many of the valleys of their trees. The Elk's denuded banks rapidly eroded, and the creek's famously clear water turned brown with sediment. As the fish became scarcer, watershed residents began looking for ways to restore the Elk.
Starting with only a few dozen volunteers, the stream's boosters planted thousands of trees and shored up miles of riverbanks with retention walls made of tree stumps. Today the trout are rebounding, and Elk Creek has become only the third waterway in state history to graduate from Montana's official list of "impaired" waterways.
"None of us were environmental maniacs, but we all wanted a healthy creek," says local resident Mike Miller. "What we kept hearing was we had to look at the entire watershed. We had to make sure we didn't have problems upstream that would blow out what we were doing downstream."
For other watersheds, cleanup progress has been maddeningly slow. Neighbors of Lake Tahoe on the California-Nevada border, for example, still have little to cheer about after nearly 40 years of efforts to restore the lake's famous crystal clarity.
Tahoe is North America's largest alpine lake and the eighth-deepest freshwater body in the world. A century ago, its waters were so pure a visitor could see objects at depths of more than 100 feet. But runaway development in recent decades brought changes that sullied the lake's waters. Today the maximum depth for visibility has dropped to 69 feet and is worsening at a rate of a foot a year. A study last year warned the lake's clarity could be "irreversibly doomed," and many of its fish and wildlife lost, without a dramatic restoration effort.
Attempts to curb runoff at Tahoe are now underway. Local authorities from communities along the lake have adopted some of the nation's toughest curbs on runoff, requiring landowners to, for example, install water traps and overflow tanks to prevent rainwater from leaving their property. But even with such measures, it may be years before significant improvements are seen.
"There's no easy fix for these problems," says Murray. "But in a lot of communities, people are coming up with workable solutions. It makes you wonder: What's holding back the states from doing the same?"
NWF Priority: Safeguarding America's Watersheds
The above map shows the results of an NWF assessment conducted last year of state efforts to control nonpoint pollution using the watershed-restoration provision of the Clean Water Act. In the study, NWF assigned a grade of "D" or "F" to 38 states. A dozen others earned a "C" or "B," and no state received an "A." "There are other tools to control runoff," says Kari Dolan, an NWF water resources specialist. "However, because many sources of polluted runoff are industries with political might, some states lack the leadership to confront them. That is why the Clean Water Act restoration provision is essential."
The study is part of NWF's ongoing Saving Our Watersheds program, designed to provide citizens with an understanding of how watersheds work and what tools are available to help protect local lakes, rivers and estuaries. NWF currently is working with activists and scientists on specific watershed projects throughout the country, including:
Joby Warrick is a staff writer for The Washington Post.


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MayaRefugee wrote:SDC, just read the piece you linked.
It deals with the theme i'm pondering very well, thank you so much for your help.
yuuki, it's too late at the moment for me to read your links but I will definately read them tomorrow, thank you also for your help.
yuuki wrote:I have read that the Buddha remained agnostic about the self. What anatta means, and I think this is very important, is that none of the five aggregates are self. I tend to take Thanissaro Bhikkhu's view on this that he gives in "No-self or Not-self?": http://www.accesstoinsight.org/lib/auth ... self2.html
Chula wrote:Thanissaro Bhikkhu's point in a nut-shell is that not-self is a teaching to be used - not a metaphysical statement. This doesn't mean being "agnostic" about the self - that would imply that the Buddha thought that it could be either way - which falls into the wrong view similar to the "eel-wriggling" evasive Sañjaya Bellattaputta. It means that the teaching of not-self is to let go of suffering - not for making metaphysical statements about the nature of reality. What the Buddha says is that whatever is inconstant and suffering is unworthy of regarding as a self.
MayaRefugee wrote:yuuki, just read your links - BRILLIANT!
Thanks so much...
yuuki wrote:No-Self seems begs the question, "What is reborn if there is no Self?"
Sanghamitta wrote:The term " No- self " is a thorny problem. " Anatta" literally means, " No Atman ".
Dan74 wrote:I heard a teacher once say that before one is truly ready to let go of a self, one's got to have a strong healthy self.
What this means in practice is that if my life is in shambles because I am unable to carry out my responsibilities I may long for a "no-self" kind of thing as a release from this "burden" but this is completely wrong. Or if I think my life is fantastic ... it's important not to misunderstand anatta teachings as a carte blanche to neglect one's responsibilities and become absorbed in oneself only.


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At Ridgewater College, you'll experience a friendly and inviting environment that provides high quality education at an affordable price. You can choose from over 100 educational opportunities in degrees, transfer programs, and career training.
Campus visits are an important step for students in deciding which college they will attend and what program/major they will pursue. After visiting our campuses and exploring our program areas, we feel confident that you will want to become a Ridgewater College student.
Call to schedule an individual appointment. Campus tours available daily during academic year and by appointment during the summer.
Call to schedule an individual appointment. Appointment times will vary depending on the program(s) an individual is planning to visit during the academic year.