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Stiletto Stoners: The Female Face of Pot Smokers?
We are clearly deep in the throes of a national conversation that posits whether or not marijuana is safer than alcohol, and whether or not the former should be legalized. But this time, fashion magazine Marie Claire wonders: what is the changing face of a pot smoker?
Turns out…it's women.
Not that women haven't been smoking pot for decades. Not that all women wear stilettos or even read Marie Claire. But these are the women deemed "successful" and powerful in society as of late–these Stiletto Stoners. But power to them, who better to make the case?
According to an interview on The Today Show with Mat Lauer, magazine editor-in-chief Joana Coles, a successful 30-something book editor (who remains anonymous), and a NYU Psychiatrist, it seems weed is completely misunderstood. As a matter of fact, this year, eight million women smoked pot. But these smokers aren't your stereotypical Judd Apatow-slackers, or someone who's "sleeping on a bench" as Coles puts it. These are educated, career-minded professional women who just "want a way to unwind" and have found that marijuana "has less impact on them when they go to work the next morning." She adds that these women "didn't want to drink" and that marijuana is "cheaper" than alcohol. And since these are hard times, women see weed as their glass of wine, their bubble bath. Their (somewhat) guilty pleasure, in other words. But should they feel guilty?
Verdict says: No. Not guilty. Legit.


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This site plus numerous others show that the technologies exist to ease our dependence on foreign oil but what we (the US) lack is the political will to make this happen. Is this a result of our people not seeing or believing there is a problem or just too much inertia around the status quo.
We've recently launched a web site (www.ei2025.org) and will start informational advertising to to the American public in an attempt bring this issue center stage. Our goal is to garner enough names on a National Petition in order to make supporting Energy Independence - politically safe.

subset: commoncrawl


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The Nano-Spintronics-Cluster-Tool
The Nano-Spintronics-Cluster-Tool is a dedicated experimental platform for magnetism- and spintronics-related activities in our institute and integrates various complementary methods into a single instrument within an ultrahigh vacuum environment (UHV).
The Nano-Spintronics-Cluster-Tool is a dedicated experimental platform for magnetism- and spintronics-related activities in our institute and integrates various complementary methods into a single instrument within an ultrahigh vacuum environment (UHV).
A central part of the Nano-Spintronics-Cluster-Tool is a high-resolution scanning electron microscope (SEM). The spatial resolution limit at high beam energies (30 keV) is 3 nm, while a beam booster improves the resolution at low beam energies (down to 0.1 keV). A high beam current of up to 5 nA in combination with an electron spin polarization detector allows fast structural and magnetic studies (SEMPA) to be carried out on the mesoscale at variable temperatures (700 down to 30 K).
The magnetic nanoscale is accessed by means of an integrated low-temperature spin-polarized scanning tunneling microscope (SP-STM) operating at temperatures as low as 4.5 K. The sample preparation chamber features a variety of proven surface science techniques. Ultra-thin films can be deposited from nine electron-beam evaporation sources. Reflection high-energy electron diffraction (RHEED) during evaporation and low energy electron diffraction (LEED) together with scanning tunneling microscopy (STM) allow atomic scale structural characterization.
A dedicated chamber allows magnetic molecules to be deposited by various methods. Chemical composition and the cleanness of surfaces are determined with Auger electron spectroscopy (AES) and x-ray photoemission spectroscopy (XPS). Magneto-optical Kerr effect (MOKE) measurements permit in-situ magnetic characterization of magnetic thin film systems.
Finally, the system provides three approaches for in-situ structuring: (i) shadow deposition through microapertures for contact pads, (ii) focused ion beam (FIB) etching in dual-beam configuration with the SEM for writing arbitrarily-shaped structures of sizes down to 20 nm, and (iii) scanning tip structuring by STM for length scales below 20 nm. Thus, 6 orders of magnitude in sample size can be covered. The STM and SEM stages feature four electric contacts to the sample, which allow in-situ electric transport measurements.
Dr. Frank Matthes
Dr. Daniel E. Bürgler
Figure: Top view of the Nano-Spintronics-Cluster-Tool: The left chamber houses the SEM, the spin polarization detector, and the FIB. The chamber on the right side contains the low temperature STM in the front part with the preparation and analysis chamber at the back. A transfer chamber (middle) connects the two units and enables in-situ access to all attached preparation and characterization tools without a vacuum break.
1. Magnetic contrast with SP-STM
2. Detection of pure spin currents in in-situ fabricated and measured lateral spinvalves
3. Accessing 4f-states in single-molecule spintronics
4. Deposition of NdPc2 on differently reactive surfaces
5. Temperature-dependent domain structure of in-situ grown FeRh thin films on MgO(100) observed by SEMPA
1. Magnetic contrast with SP-STM
We tested the performance of the STM and the ability to achieve spin contrast by investigating thin (1–2 ML) Fe films on W(110), the standard test system for SP-STM [O. Pietzsch et al., Phys. Rev. Lett. 84, 5212 (2000)]. An in-situ grown Fe wedge is studied in an area where the Fe film is 1.5 ML thick and thus exhibits areas with one or two ML Fe coverage, respectively. We used an etched, chemically-wet tip made of antiferromagnetic bulk Cr. The figure shows the simultaneously acquired topography (a) and differential conductivity (dI/dV) map at E-EF=-300 meV (b) as well as a 3D representation of the topography coloured according to the spectroscopic data (c). The experiment was performed at 4.8 K.
The topography image (a) was measured in the constant-current mode with a gap voltage of -300 mV addressing occupied states and a tunnelling current of 2.5 nA. The scan area (180 nm x 180 nm) comprises 3 surface steps of the W(110) substrate and spans a total height difference of about 0.8 nm, including the islands on the topmost terrace.
The post-annealing treatment at 560 K causes the Fe atoms in the second ML to diffuse to the step edges, where 2 ML high Fe stripes are formed [red marks in (c)]. Dislocation lines in the 2 ML areas [red arrow in (a)] run along the [001] direction. The simultaneously recorded dI/dV map at E-EF=-300 meV in (b) displays strong contrast in the 2 ML areas only. The dislocation lines appear as bright lines running along [001].
The alternating brown/yellow contrast is due to magnetic domains of the out-of-plane magnetized 2 ML-thick Fe film. The first Fe ML on W(110) is in-plane magnetized and does not contribute to the magnetic contrast of this image. The conductivity map was measured by lock-in detection at a frequency of 2700 Hz and a peak-to-peak modulation amplitude of 42 mV. The overlay of topography and the dI/dV map in (c) gives a visual impression of the subtle nanoscale structure-magnetism correlation.
2. Detection of Pure Spin Currents in in-situ Fabricated and Measured Lateral Spin Valves
We have developed a novel multi-stage fabrication process for lateral spin valves that is performed completely in-situ in order to realize clean and well-defined interfaces. In addition, the ferromagnetic layers are topmost and thus accessible to surface sensitive techniques (e.g. SEMPA). The process is based on thermal evaporation and structuring with UHV-FIB. Our spin valves comprise two ferromagnetic Co wires of different length that are attached to Cu leads.
Figure: SEM micrograph of an in-situ fabricated lateral spin valve. FM1 and FM2 are ferromagnetic Co wires (blue) attached to Cu leads C1 to C4 (red)..
For the non-local transport measurements, a current I is applied between C1 and C4 in order to create spin accumulation in the Cu lead between C1 and C2. The pure spin current signal is detected as a voltage VS across C2 and C3, which depends on the relative magnetic alignment of FM1 and FM2..
Figure: Pure spin current signal RS=VS/I measured for two different excitation currents. The two levels in each measurement correspond to the parallel and antiparallel alignment of the magnetizations in FM1 and FM2. The magnitude of the effect of about 1 mΩ indicates clean interfaces.
The non-reproducible switching (e.g. at negative magnetic field) is due to the formation of magnetic domains in the Co wires, which are stabilized by ion-beam induced roughness of the substrate. The SEMPA measurements indicate the formation of the so-called concertina domain structure.
Figure: SEM topography and corresponding SEMPA image of the ferromagnetic wires. In spite of their dimension (10 nm thick, 220 to 280 nm wide, and approximately 4 µm long) they reveal a rich domain structure similar to the schematically-shown concertina structure.
Original Publication:
J. Mennig, F. Matthes, D. E. Bürgler, and C. M. Schneider
Observation and implications of magnetic domains in lateral spin valves
J. Appl. Phys. 111, 07C504 (2012)
3. Accessing 4f-states in single-molecule spintronics
Magnetic molecules are potential functional units for molecular and supramolecular spintronic devices. However, their magnetic and electronic properties depend critically on their interaction with metallic electrodes. Charge transfer and hybridization modify the electronic structure and thereby influence or even quench the molecular magnetic moment. Yet, detection and manipulation of the molecular spin state by means of charge transport, that is, spintronic functionality, mandates a certain level of hybridization of the magnetic orbitals with electrode states.
We have shown how a judicious choice of the molecular spin centres determines these critical molecule–electrode contact characteristics. In contrast to late lanthanide analogues, the 4f-orbitals of single bis(phthalocyaninato)-neodymium(III) molecules (NdPc2)adsorbed on Cu(100) can be directly accessed by scanning tunnelling microscopy. Hence, they contribute to charge transport, whereas their magnetic moment is sustained as evident from comparing spectroscopic data with ab initio calculations.
Our results showcase how tailoring molecular orbitals can yield all-electrically controlled spintronic device concepts.
Figure: Calculated adsorption geometry of NdPc2 on Cu(100) (light grey, Cu; dark grey, W; magenta, Nd; blue and green, Pc ligands; with N dark, C medium, H light colour). (a-p) Comparison of experimental data with density functional theory simulations: (a–d) Experimental and (e–h) theoretical topography images, (i–l) experimental and (m–p) theoretical dI/dV maps for various Vbias as indicated.
Original Publication:
S. Fahrendorf, N. Atodiresei, C. Besson, V. Caciuc, F. Matthes, S. Blügel, P. Kögerler, D. E. Bürgler, C. M. Schneider
Accessing 4f-states in single-molecule spintronics
Nat. Commun. 4, 2425 (2013)
This work was also highlighted by Nature Nanotechnology
4. Deposition of NdPc2 on differently reactive surfaces
Realizing spintronic devices based on magnetic molecules requires that the molecules are adsorbed on substrates and/or electrodes. Thereby, the substrate-molecule interaction possibly modifies the structural, electronic, and magnetic properties. We have addressed the question about the stability NdPc2 molecules on differently reactive substrates such as Au(111), Cu(100), and 2 atomic layers Fe on W(110). We found different fractions of intact double-decker molecules on Fe/W(110) and Cu(100) and only decomposed single-decker Pc fragments on Au(111). Hence, the NdPc2 stability increases with increasing molecule-substrate interaction.
We explain this finding by charge transfer from the substrate to the lower Pc ligand of the NdPc2 molecule, which increases the intramolecular electrostatic interaction between the negatively charged Pc ligands and the Nd3+ ion. Stronger substrate-molecule interaction leads to larger charge transfer and thus increased stability of the double-decker molecule.
Figure: (a) Overview image after depositing NdPc2 molecules from a sublimation oven onto a Cu(100) surface showing some intact double-decker NdPc2 molecules (b) and a larger number of single-decker Pc fragments (c). The fraction of intact double-decker NdPc2 molecules depends on the substrate material and increases with the corresponding adsorption energy (d).
5. Temperature-dependent domain structure of in-situ grown FeRh thin films on MgO(100) observed by SEMPA
Exchange systems comprising a FeRh layer showing a temperature-induced metamagnetic transition from antiferromagnetic (AFM) to ferromagnetic (FM) and a hard magnetic layer are intensively discussed as a promising approach for heat-assisted magnetic recording that can largely increase the storage density of hard disk drives.
Recent work has indicated the coexistence of both AFM and FM states in capped single-crystalline FeRh thin films on MgO. Domain structures observed at the interface between the FeRh film and the capping layer revealed FM order, whereas the bulk of the FeRh film was in the AFM state. However, from these experiments it is not clear whether the coexistence of AFM and FM order is an intrinsic property of FeRh films or an artifact due to capping or contamination layers.
We have prepared 10 nm thick single-crystalline FeRh films on MgO(100) by separate layer deposition of Fe and Rh and performed structural, chemical, and magnetic characterizations in-situ without capping layers. Thus, we studied the intrinsic properties of the single-crystalline FeRh films without exposure to air or additional cleaning steps.
The FeRh films exhibit the metamagnetic phase transition from AFM to FM below room temperature as indicated by in-situ MOKE measurements. Temperature-dependent domain structures imaged by SEMPA at temperatures between 122 and 450 K reveal that FM domains exist at the surface, while the bulk is AFM. The domain size changes drastically with temperature, which is related to a spin reorientation transition from out-of-plane to in-plane between 350 and 400 K. The results show that the previously observed coexistence of the FM state at the surface and the AFM phase in the bulk is an intrinsic property of (100) surfaces of single-crystalline FeRh thin films on MgO(100).
Figure: SEMPA images of an in-situ prepared FeRh thin film measured at different temperatures as indicated. Images are taken at the same sample spot (see circles) and in the sequence (a) to (h). Panel (i) shows the colour-wheel for the representation of the SEMPA data. Different colours indicate the magnetization direction and the colour saturation the magnitude of the spin polarization.


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San Jose Rep Delays NEXT FALL to Secure Danny Scheie as Lead, Oct 2013
San Jose Rep will be postponing its scheduled production of Next Fall until October, 2013. San Jose Rep is thrilled to announce that they were able to secure actor Danny Scheie to play the lead role in the thoughtful, moving story written by Geoffrey Nauffts, but his availability for the project required San Jose Rep to push the production to a later date.
"Next Fall is a very important production for our community," says Rick Lombardo, San Jose Rep's Artistic Director. "We wanted to produce this insightful, emotional story in the best way possible and couldn't be happier that our first choice actor, Danny Scheie, will be taking on the lead role."
Danny Scheie is a Bay Area theatre veteran with undeniable talent who began working in Bay Area theater in 1983. In his more than three decades here, he has built a reputation as a reliably adventurous director, an artistic director, a teacher, and as an actor. Regarded as one of the best in Northern California, Scheie has performed in a multitude of theatre productions from Santa Cruz to San Francisco, and is excited to embody his role in Next Fall.
"Perhaps one of the allures of acting for everyone, professional and amateur and child alike, is the adventure of becoming someone wildly different than one's self," Scheie explains. "The chance to play a gay middle-aged urban neurotic, frankly down-the-line severe casting-to-type, is in my career uncharacteristically exotic. I am thrilled and honored at being invited by Kirsten Brandt and San Jose Rep to take this ride within."
San Jose Rep will fill Next Fall's original dates in April with the The Tragical History of Doctor Faustus, the best known work of English Renaissance playwright Christopher Marlowe. The play is based on the story of Faust, a protagonist of German legend, who sold his soul to the devil for unlimited knowledge and worldly pleasures. This production will pair a dramatic 17th century script with innovative high-tech stagecraft designed by director Kirsten Brandt.
"I have always wanted to direct Doctor Faustus," Brandt reveals. "Besides being intellectually stimulating, the story is funny and tragic, and like a good classic, completely relevant to contemporary issues."
Brandt has been praised for her cutting edge techniques, taking the art of theatre to new technological heights. In March of 2012 at UCSC, she wrote and directed The Thinning Veil, a production that took place in two theatres simultaneously with live video from each theatre being broadcast into the other. The Santa Cruz Sentinel called the production "something completely different" and referred to it as "an original telematic play for the 21st century."
For the The Tragical History of Doctor Faustus, Brandt plans to blend traditional stagecraft with the modern media. "Too often, media design is relegated to scenery. I'm interested in how the live performer interacts with projected media - how the two interface," says Brandt. "Doctor Faustus is filled with magic and non-human characters and with a cast of four actors, playing over 30 characters, the need for innovation is a must."
Next Fall tickets daTed May 9 - June 2, 2012 will honored for the same date and performance time for The Tragical History of Doctor Faustus.
by Christopher Marlowe
Adapted and directed by Kirsten Brandt
by Geoffrey Nauffts
directed by Kirsten Brandt
San Jose Rep is the flagship theatre of San Jose and the only fully professional, non-profit theatre company in the South Bay, presenting seven main-stage productions each year. Now in its 32nd year as a major contributor to the South Bay's cultural community, San Jose Rep's mission is to engage, entertain, and inspire people. San Jose Rep produces innovative theatrical performances that offer fresh perspectives into the human condition, educational programs that promote lifelong learning, and outreach initiatives that benefit our diverse community. For more information, visit www.SJRep.com.


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Editor's note: Every NFL team is preparing to attack its offseason to-do list, with free agency set to open March 12 and the draft April 25-27. This is the 14th of 32 reports in 32 days by Sporting News NFL correspondents, who will analyze the offseason game plan for each team. Thursday: Cleveland Browns.
Talent overview
One of the dangers of having a successful run of draft classes is that eventually those second contracts come due. For the Cincinnati Bengals, that run of trying to keep a core of young players begins this offseason.
The most important free agents for the Bengals are the ones on their own team. Right tackle Andre Smith and defensive end Michael Johnson are at the top of the list, but another priority should be trying to extend the contract of defensive tackle Geno Atkins, who led the league's interior linemen with 12.5 sacks last season.
With 23 unrestricted free agents, coach Marvin Lewis said it is unrealistic to expect the team to retain them all. But if the Bengals are going to make the playoffs three straight years for the first time in franchise history, keeping most of the defense intact will be a priority.
— AFC rivals: Ravens | Patriots | Jets | Dolphins | Bills
Key departures
Middle linebacker Rey Maualuga came in with a lot of fanfare in 2009 when he was drafted in the second round, but he has not lived up to expectations and has struggled the past two years. If Maualuga departs, as expected, Vontaze Burfict — who led the team in tackles as a rookie last season — could move back to his natural position in the middle.
Also not likely to return are linebacker Manny Lawson, who was on the field for only one third of the snaps; running back Bernard Scott, who has been plagued by injuries, and wide receiver Brandon Tate.
1. Outside linebacker. If the Bengals do not re-sign Maualuga, Burfict would move to the middle. Thomas Howard played in only one game last season because of a knee injury but led the team in tackles in 2011. They also have some young, unproven talent in Emmanuel Lamur and Dontay Moch.
Houston Texans free agent Connor Barwin would be a good target but is likely to be out of the Bengals' price range considering the money they need to allot to re-sign Smith and Johnson. A more realistic possibility is Jacksonville Jaguars' Daryl Smith, who will be 31 going into next season and might want to play for a contender.
2. Safety. After Reggie Nelson, who tied for the team lead in interceptions with three and can play either free or strong safety, there is a big drop-off at the position. Chris Crocker was re-signed before Week 4, and Nate Clements saw action there during the first half of the season. Crocker could be re-signed, but it's more likely the Bengals will look to the draft to get better at the position.
Texas' Kenny Vaccaro and Florida's Matt Elam should get consideration when the Bengals pick 21st overall in the first round. If the Bengals look to free agency, the Detroit Lions' Louis Delmas could receive some interest since he isn't expected to command a huge price tag.
3. Running back. BenJarvus Green-Ellis had a career-best 1,094 yards last season and had four 100-yard games down the stretch, but the team would prefer to use a committee approach rather than rely heavily on Green-Ellis.
Many have linked Miami Dolphins free agent Reggie Bush to the Bengals, and he would provide a nice change-of-pace option. But it is difficult to envision Bush in stripes considering the list of players the Bengals must re-sign. The Bengals look to the draft, which has plenty of depth at running back in Rounds 2-4, with North Carolina's Giovani Bernard, Clemson's Andre Ellington and UCLA's Johnathan Franklin.
4. Cornerback. Leon Hall came back from his 2011 Achilles' injury and had three interceptions in the last four games, including two he returned for touchdowns. The Bengals drafted Dre Kirkpatrick in the first round last year, but he missed most of the season due to injuries. Even if the Bengals re-sign Adam "Pacman" Jones and Terence Newman, which appears likely, they have to start getting younger at the position. It is possible they could draft a corner in the early to middle rounds.
5. Quarterback. Andy Dalton is 19-13 as the starter in his first two seasons. But with Bruce Gradkowski a free agent, there remains a question about who will be the backup. Zac Robinson has been on the practice squad the past two seasons, but the team could look to the late rounds to bring someone in to compete for the backup spot. Or they could bring back Gradkowski with a one-year deal.
Reedy's take
The Bengals enter free agency with the most cap room of any team at nearly $53 million. But considering the cap will remain flat the next couple of seasons, they have a lot of decisions to make this offseason and next offseason about how many of their core players they are willing to keep.
They did a good job of that on offense in 2006, locking up most of the starters, but injuries and immaturity both on and off the field ended up catching up to them. This group seems better prepared to handle success and adversity, as evidenced by a 7-1 finish to make the playoffs after a 3-5 start last season.
The ultimate indicator, though, is playoff success, and this franchise will enter the upcoming season at 22 years and counting without a postseason win.
The Bengals should enter the season as a playoff contender, but they need more consistency on offense and more big plays from Dalton if they are to reach the next level. They also need to keep the core of their pass rush on defense.
Joe Reedy covers the Bengals for Sporting News and the Cincinnati Enquirer.


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Girlfriend Appreciation DayLogic Grid puzzles come with a handy interactive grid that will help you solve the puzzle based on the given clues.
Five brothers share a common trait of forgetfulness that has gotten them in hot water with their girlfriends. After a string of forgotten birthdays, anniversaries and even dates, the brothers' girlfriends were fed up. After a brainstorming session, the brothers devised a new holiday - Girlfriend Appreciation Day. For the big day, the five brothers have dates with their girlfriends. Each one bought a different gift and a dozen roses of a different color. Each couple is going to a different destination on their date. Determine each brother's name, the name of their girlfriend, the gift and color of roses he is giving her, and their date destination.
Brothers - Ted, Tim, Tom, Travis, Tyler
Girls - Andrea, Brooke, Jessica, Laura, Vanessa
Gift - Bracelet, Candy, Music Box, Necklace, Ring
Color of Roses - Pale Purple, Pink, White, Red, Yellow
Date Destinations - Basketball Game, Dinner, Ice-Skating, Movie, Theater
1. The five brothers are: Tyler, the brother giving his girlfriend the ring and red roses, the one giving his girlfriend pink roses, the one taking Laura to a movie, and the one taking his girlfriend ice-skating.
2. The five girlfriends are: Andrea (who isn't going to the basketball game), the woman getting the ring, Brooke (who isn't getting the bracelet); Ted's girlfriend, and the one getting the candy and the yellow roses.
3. The brother taking his girlfriend to the movie is either Tim or Tyler (who isn't giving his girlfriend the necklace).
4. Vanessa and Ted's girlfriend (who isn't receiving the necklace) are, in some order, the woman going to the theater and the one receiving white roses.
5. Neither Travis nor Tom (whose girlfriend isn't Andrea) is taking his girlfriend to the basketball game.
HintAnything in parentheses refers to the word immediately before the parentheses. For example: In Clue 3 Tyler is not giving his girlfriend the necklace.
AnswerTed, Jessica, Bracelet, White, Ice-Skating
Tim, Laura, Candy, Yellow, Movie
Tom, Vanessa, Ring, Red, Theater
Travis, Andrea, necklace, Pink, Dinner
Tyler, Brooke, Music Box, Pale Purple, Basketball Game
What Next?
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Versace Essence Etheral Perfume
By Versace for Women
Versace Essence Etheral Perfume by Versace, Launched by the design house of versace in 2000, versace ethereal is classified as a refreshing, flowery fragrance . This feminine scent possesses a blend of floral violets, mimosa and iris, with hints of musk. It is recommended for casual wear. All products are original, authentic name brands. We do not sell knockoffs or imitations. ... Read More
- Y Tu Tambien
- Yardley Iris
- Yardley London
- Yardley London Soaps
- Yardley Peony
- Yellow Jeans
- Yendi
- Yendi De Capucci
- Yerbamate
- Yes We Can
- Yin
- Yin 2
- Yin Yang
- Ylang In Gold
- Yohji Essential
- Yohji Yamamoto
- You & I
- You & Me
- You Are Divine
- Young For Ever
- Young Sexy Lovely
- Youth Dew
- Youth Dew Amber Nude
- Ysatis
- Ysatis Iris
- Ysl
- Yujin Art
- Yujin Ecstacy
- Yujin Paradise
- Yujin Sensual
- Yujin Star
- Yujin Starnight
- Yves d'Orgeval
- Yves De Sistelle
- Yves dOrgeval
- Yves Rocher
- Yves Saint Laurent
- Yves Sistelle
- Yvresse
- Yvresse Legere
- YZY Perfume
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About Versace
History and background of Versace. Gianni Versace was born in Reggio Calabria, Italy, on December 2, 1946. After an apprenticeship at his mother's dressmaking business, he began working as a freelance designer. At age 25, Versace was creating prêt-à-porter collections for top fashion houses of the time, including Genny, Complice and Callaghan. Read more about Versace
More Versace fragrancesfor Women: Bright Crystal , Crystal Noir , Versace Eros , Versace Yellow Diamond , Versace Signature , more
for Men: Versace Eros , Versace Man , Versace Pour Homme , Versace Pour Homme Dylan Blue , Versace L'homme , more
See all Versace products
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Thanks for carrying such a great selection.
S. Horton (Grand Prairie, TX)
REVIEW SNAPSHOT®by PowerReviews
Best Uses
- Fragrance Type:
- Floral (3)
Reviewed by 3 customers
- Long-Lasting
- Doesn't Hold
Best Uses
- Evening Use
- Special Occasions
Comments about Versace Essence Etheral Perfume:
not for me
- Gift:
- No
- Fragrance Type:
- Floral, Oriental/Spicy, Woody/Earthy
- Clean & Fresh
- Great Smell
- Great Value
- Long-Lasting
Best Uses
- Daily Use
- Work
Comments about Versace Essence Etheral Perfume:
I loved this fragrance the longer I had it on. The way it blended throughout the day was nice. Not overpowering, but better as the day progressed.
- Gift:
- No
- Fragrance Type:
- Citrus/Fruity, Floral
- Clean & Fresh
- Draws Compliments
- Great Smell
- Great Value
- Sexy
Best Uses
- Daily Use
- Work
Comments about Versace Essence Etheral Perfume:
First given to me as a gift by my husband years ago. found it again here at fragranceX. Great price. Ethereal smells great!
- Gift:
- No
- Fragrance Type:
- Floral, Powdery


text:
Funky Monkey Hostel
The Funky Monkey hostel offers 8 and 16 bed dorms and private rooms all with A/C, Wi-Fi, laundry service, lockers (buy your own lock), 24 hour security and reception, a breakfast "bar" with food and drinks in the lobby and free tourist information with maps and consultation which includes visa service, bus tickets, airline tickets, train tickets and some tours to Vietnam and other parts of Asia. There is a common room with Wi-Fi, TV, A/C, pool table (playing pool is free), sofa's etc and beer/soft drinks so you can meet other backpackers or just relax away from the heat.
We have a very friendly and knowledgeable staff that can speak English and are happy to help you.
We are centrally located, close to the night market on the river and other sight seeing attractions.
The Funky Monkey Hostel is 15km from the airport, 25km from the Friendship Bridge and about 1.5km from the bus station. Tell the Tuk Tuk or taxi driver, Funky Monkey, Rue Francois Nign, Ban Mixay, Chanthabouly District near Vat Mixay.
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hostel Facilities & Policies
- 24 Hour Reception
- 24 Hour Security
- Air Conditioning
- Airport Transfers
- Bar
- Bicycle hire
- Bicycle parking
- Book Exchange
- Free Breakfast
- Cable TV
- Café
- Card Phones
- Ceiling Fan
- Common Room
- Credit Cards Accepted
- Currency Exchange
- Telephone/Fax Facilities
- Free City Maps
- Free Internet Access
- Free Parking
- Free WiFi
- Games Room
- Hot Showers
- Internet Access
- Self-Catering Facilities
- Laundry Facilities
- Security Lockers
- Luggage Storage
- Meeting Rooms
- No Curfew
- Non Smoking
- Outdoor Terrace
- Parking
- Pool Table
- Restaurant
- Safe Deposit Box
- Taxes included
- Tours/Travel Desk
- Towels For Hire
- Wheelchair Friendly
Cancellation PolicyThis property has a 1 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
DirectionsShow MapHide Map
Funky Monkey Hostel Property is 15 km from the airport, 25 km from the Thai border and at least 15 km from any bus station. Tell the Tuk Tuk or Taxi driver to go to Mixay Temple on Francois Ngin Road, the property is across the street from the Mixay Temple. You can call the property for directions, we speak English and Laos.
Located Near
Funky Monkey Hostel Property is in the center of the Vientiane backpacker area. There are many bars and restaurants within walking distance of the property. The night market is only a 2 minute walk.


text: Childress passes first test By Dave Hickman September 15, 2013 Story Share AP Photo WVU quarterback Ford Childress completed 25 of 41 passes for 359 yards and three touchdowns in his debut Saturday. MORGANTOWN - The act of installing Ford Childress as West Virginia's starting quarterback didn't really begin until last week. It was accomplished more or less in a couple of days of practice, when he and Clint Trickett were given equal opportunities in practice and Childress emerged - according to Dana Holgorsen - as the clear leader.In truth, though, the process began long before Holgorsen opened up the competition. It was a slow build, of sorts, since right from the time Holgorsen originally demoted Childress to third team and limited the competition prior to the first two games to Trickett and Paul Millard."When we [told him to] sit back and watch, he sat back and watched,'' Holgorsen said. "And in his mind he was like, 'Dang, I could be playing right now.' He sat on the sidelines and said, 'I can do that,' or 'I would have done this.' He convinced himself that it was his time to play and he got out there and played well.''Indeed, in his first-ever appearance in a college football game, Childress played well enough to complete 25 of 41 passes for 359 yards and three touchdowns in Saturday's 41-7 rout of hapless Georgia State. He was certainly not perfect, much of his success directly related to the level of competition he and the rest of the offense faced, but Holgorsen saw it as a good start."He's a redshirt freshman and he's got a lot of potential,'' Holgorsen said. "He played well. He'll keep getting better and better.''What Holgorsen liked most about Childress' performance was the way he handled himself. No, his throws weren't perfect, nor were his reads. Holgorsen still doesn't like the tempo of the offense at times, either, and part of that falls on the quarterback.But the intangibles were all good. In fact, that's one of the things that helped give Childress the job, again even before the competition really began in practice last week. A week ago at Oklahoma, when all around him seemed to be losing their cool, Childress wasn't."Things were tight and it was a high-pressure situation,'' Holgorsen said. "He was the one that I saw being poised and being calm."I like his mentality more than anything. That gives me a start. We all know he's got some talent and he's big and he's all that. But I need his mentality to be good. And I really liked his mentality.''Again, there were times when Childress was anything but spot-on with his throws or reads in Saturday's game. Even most of the long passes he completed were only average-thrown or even poorly thrown balls, but were to receivers who were so open that precision wasn't required. Holgorsen will look at those and no doubt demand better throws. But that's not all he's looking at."I look for some different things than what you guys look for,'' Holgorsen said. "Completion percentage and yards and all that stuff I really don't pay much attention to. I thought his body language was good. I thought he handled the huddle pretty good. Coming to the sidelines he was communicative. Whether it was O-line, running backs, receivers, me, [offensive coordinator] Shannon [Dawson], I thought he did a good job of just being in the game."That's what we're looking for. If you've got a guy like that who can handle those situations and understand the game of football and understand what's going on out there, then you can get to the sidelines and you can bring a lot of other guys along with you.''Perhaps Childress understands that, too. Even when the offense went into a lull against Georgia State Saturday - just one touchdown in seven possessions in the second and third quarters - he maintains he wasn't worried about being lifted in favor or Trickett or Millard."I didn't really feel that way,'' Childress said. "I've got good enough players around me that I can just hand the ball off to them or throw the ball to them and they'll make a play for me.'' Certainly Holgorsen is of the mind that the job belongs to Childress. That could change if the quarterback struggles for an extended period, but the tip-off that the job belongs to Childress and Childress alone was when neither of the other quarterbacks even sniffed playing time against Georgia State."If it's not [his job] then I'm not very smart,'' Holgorsen said. "I just gave him a hundred percent of the reps.''BRIEFLY: West Virginia plays its final non-conference game of the season Saturday in Baltimore against Maryland. The game is at the Ravens' M&T Bank Stadium and kicks off at 3:30 p.m. It was announced Sunday that the game will be televised on ESPNU.Maryland is 3-0 after Saturday night's 32-21 win at Connecticut. The Terps previously won lopsided games over Florida International and Old Dominion.Reach Dave Hickman at 304-348-1734 or firstname.lastname@example.com or follow him at Twitter.com/dphickman1. Story Share Story Share Trending Now 1 Facebook founder visits Charleston restaurant 2 WVU seeking improvements during off week 3 Innerviews: Dual-identity surgeon riding high in horse racing world 4 Gazette editorial: Capito has second chance to do the right thing 5 Rod Run and Doo Wop brings classic cars, music to Boulevard for 12th year Nobody wants to upset NCAA's rotten apple cart Previous Story Like Ohio, Hokies have had Herd's number Next Story


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A few weeks ago I was contacted by API (Automated Processes Inc) to say a few words about my API Lunchbox, 512C mic pre and 527 compressor. There is little reason not to endorse the American company which makes my vocals sound better than any string of plug-ins. As you can tell by this blog I enjoy music tech as much as making music and in the past I've endorsed products from TC Electronic, D16 and Linplug Instruments. If you have been on the fence deciding which brand of high end micpre to get just grab a 512c and be done with it. You won't regret it.
"The 512c brings my voice from somewhere low behind the speakers directly into the center of my brain." – Oliver Chesler
Read the full article: apiaudio.com/word_400.html


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Milestones and Influences
Talk shows. Radios. Cell phones. Everywhere we go, we see evidence of the value we place on the spoken word. We equate verbal eloquence with intelligence or success. Little wonder, then, that we parents are so eager to have our children achieve—or exceed—the standard milestones for speaking. Missing those milestones has become a signal for worry and an indicator of other more fundamental problems.
Yet Einstein was a late talker, and so were many notable scientists, engineers, economists, columnists—and possibly even the person who helped you the last time your computer wouldn't go online. When is late talking simply a matter of temperament and not a symptom of a neurological or learning disorder?
In general, most children follow this path to speech:
- Cooing and babbling socially (in response to your vocalizations) around age two months
- Some "syllables" (la-la, abu, nanana) around age six months
- One word utterances (mama, dada) by age one
- Two word sentences by age two: "Cookie allgone!" (bye-bye, allgone are considered one-word utterances in this case)
- Three or more word sentences by age three
- Adult style speech by age four, with some allowance for grammar and pronunciation. "Wascally wabbit!" or "Him and me played."
As with all developmental milestones, children reach them at varied rate. Some talk at 10 months, others may wait another six. Likewise, genetic and environmental factors may come into play. A history of "naturally" late talkers in the family who "grew out of it" is one example. Children growing up in bilingual homes may need more time to process the different vocabularies and grammars—but when they do, what an advantage!
Some parents of late talkers say their children were simply less motivated toward early speech; they had older siblings ready to anticipate their needs and speak for them. However, these children are most likely inclined towards waiting; otherwise the youngest child would always be the late talker.
Sometimes, learning style plays a part. Stephen Camarata, a speech-language pathologist with over 20 years' experience working with late talkers, said that he's seen children who are more prone to perfectionism wait until they can enunciate and speak at an adult level—something they simply cannot do in the toddler years. Others may put speech aside while learning something new.
Laila Bernhartsen's son suddenly stopped babbling at eight months; neurological tests showed he was doing fine except in the area of speech. He did "o.k." at therapy, but months later, surprised his mom by correctly identifying every letter in the alphabet, even flipping M to make W. "It became apparent that he also was able to read. His therapist later told me it is not really unusual for boys (especially) to learn one thing at a time, and when they discover that they can move, manipulate their environment, or any new skill, they put others (esp. speech) aside," she said.
Red Flags: When Speech Indicates a Problem
"Based on studies in the literature, 50 to 60 percent of late talkers 'recover' without treatment," noted Camarata. However, late speech can indicate a variety of neurological or developmental problems such as autism, verbal apraxia, deafness and other learning disabilities. If your child is delayed in his speech development, especially if by more than a couple of months, or if he drops a speech skill he'd gained, you should keep a close watch for other risk factors such as:
- Overall developmental delays: in fine motor skills (picking up things, scribbling), gross motor skills (walking), intellectual (recognizes person or object, follows directions)
- Does not gesture or point by a year
- Lack of social interaction: making eye contact, imitating sounds or actions, attempting to communicate nonverbally, demonstrating that she knows the difference between people and objects, playing creatively or symbolically (rocking the baby doll, driving cars to the store, making dinosaurs fight)
- Uses only vowels, or does not use a variety of consonant/vowel combinations (la-da, abunana) by 8 months; has no single words by 16 months
- Stereotypical behavior: spinning objects, flapping hands, or obsessive behaviors like lining up cars or crayons but not playing with them
- Tries to speak, but cannot and is frustrated at his attempts
- Does not seem to understand what you're saying when you do not provide nonverbal cues (asking if he wants more food without showing it to him, for example)
- Does not hear you unless you are in front of him; is scared of loud noises
- Your own instincts tell you something is not right
If your child is showing one or more of these signs, have him or her assessed. "The 'worst' that can happen is that your child doesn't have a problem, and the doctor will tell you," said Dr. Marilyn Agin, a neurodevelopmental pediatrician and co-author of The Late Talker: What to Do if Your Child Isn't Talking Yet. If your child does have a problem, catching it in the years before age three when the brain's plasticity is highest increases the chance of overcoming the problem. Agin said this is especially important for verbal apraxia, a motor planning disorder that hinders a child's ability to put sounds and words together.
The first step in assessment is to see your pediatrician and rule out physical problems like deafness. Next, you may need to take your child to be assessed by someone qualified in language disorders. Camarata cautions parents to be sure they find someone very skilled at assessment. Such a person should be familiar with the different disorders associated with late talking and differentiate between them. Camarata specifically urges parents to beware the assessor who gives each patient the same diagnosis. A specialist should also be able to discern when a certain behavior is a coping mechanism or a sign of frustration by a child unable or unwilling to communicate with a stranger, and when it's the symptom of bona-fide autism, for example, or when language intervention may be needed before a more accurate diagnosis can be made.
Parents should take an active part in the process. You know your children best; you see things in day-to-day activity in many environments and situations that an assessor will not in a few hours, often in an unfamiliar environment. Bring your observations and concerns to your doctor. Ask questions; voice objections. If you do not agree with a diagnosis, and if the doctor or therapist cannot explain herself to your satisfaction, get a second or even third opinion. Do some research yourself, contact other families of late talkers, and meet families with kids who may share the same problems as your child.
The most important thing you can do for your late-talking child, be he autistic or the next Albert Einstein, is to simply love him and appreciate his uniqueness, beauty—and brains. Late talkers often have average or higher intelligence; they just express it differently.
"Remember, too, that you did not cause (late talking). Do not feel guilty or so nervous that you forget to enjoy your child," said Camarata, who is also the father of seven, one of whom was a late talker. "Don't get caught up in a label or a diagnosis. Children are full of wonder. Play with them. Talk with them. Be sure to have fun."


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"If society will not admit of woman's free development, then society must be remodeled."- Elizabeth Blackwell
March is Women's History Month! As part of the celebration and reflection, we came up with a list of some of the most important firsts made by women in history. Though this list hardly covers all the accomplishments made by women it includes some pretty notable ones. From Alice Paul to Kathryn Bigelow, all of these women have knocked down so many barriers for women today. Here are 10 famous firsts for women in history.


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Patient-Centered Adherence Intervention After Acute Coronary Syndrome (ACS) Hospitalization (MEDICATION)
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- How to Read a Study Record
We propose to test the effectiveness of a multi-faceted patient-centered adherence intervention among veterans following ACS hospitalization to improve adherence to cardioprotective medications (primary aim). Secondary aims will assess whether the intervention improves achievement of secondary prevention blood pressure (BP) and low density lipoprotein (LDL)-cholesterol goals, reduces cardiac endpoints (myocardial infarction ) MI hospitalization, coronary revascularization, all-cause mortality) and is cost-effective.
ANTICIPATED IMPACT(S) : If successful, the proposed intervention will increase adherence to cardioprotective medications (i.e., -blockers, statins, clopidogrel, and ACE inhibitors) by helping veterans take their medications routinely as prescribed, the quality of cardiovascular care for veterans by helping patients achieve BP and LDL goals which have been associated with improved outcomes, and the efficiency of care by using telephone calls and tele-monitoring for communication with patients rather than clinic visits. The findings of the study will address an important gap in knowledge (i.e., how to improve adherence to medications following ACS discharge) and will be generalizable to other VA Medical Centers and veterans.
|Acute Coronary Syndrome
|Behavioral: Intervention Behavioral: Usual care
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
|Official Title:
|Patient-Centered Adherence Intervention After ACS Hospitalization
- Adherence to Cardioprotective Medications (Clopidogrel, Statins, Beta Blockers, ACE-inhibitor/ARB) [ Time Frame: 12-months ]The primary outcome was the proportion of patients who were adherent to cardioprotective medications (beta-blockers, statins, clopidogrel, and ACE/ARB) in the year following ACS hospitalization.
|Study Start Date:
|July 2010
|Study Completion Date:
|August 2013
|Primary Completion Date:
|March 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm 1
The multi-faceted patient centered intervention will adapt elements of prior successfully adherence interventions and include the following core components: collaborative care (between pharmacists, primary care providers, and cardiologists), patient education (tailored to patient needs and provided on a regular ongoing basis), tailoring of medication regimens (i.e., simplification of dosing, use of pill boxes, synchronization of refill dates), and tele-monitoring via IVR technology as well as patient-specific aides based on identified needs.
Behavioral: Intervention
The multi-faceted patient centered intervention will adapt elements of prior successfully adherence interventions and include the following core components: collaborative care (between pharmacists, primary care providers, and cardiologists), patient education (tailored to patient needs and provided on a regular ongoing basis), tailoring of medication regimens (i.e., simplification of dosing, use of pill boxes, synchronization of refill dates), and tele-monitoring via IVR technology as well as patient-specific aides based on identified needs.
Active Comparator: Arm 2
Patients will receive usual care following ACS hospital discharge
Behavioral: Usual care
Usual care following ACS hospital discharge.
Detailed Description:
RATIONALE: Acute coronary syndrome, including acute myocardial infarction (MI) is one of the leading causes of hospitalization for veterans. Recent advances in the treatment of acute MI have led to declines in hospital mortality. Despite this, the risk of recurrent events and mortality after the index MI hospitalization remains substantial in the following year. Non-adherence to proven cardioprotective medications is a potentially modifiable risk factor that contributes to the persistently high risk of adverse outcomes following MI hospitalization. Prior interventions to improve medication adherence in cardiovascular populations have produced mixed results and have not specifically targeted patients after acute coronary syndrome (ACS) hospital discharge. It is currently unknown if interventions targeting medication non-adherence in the year after ACS discharge will improve medication adherence and intermediate outcomes or will be cost-effective
OBJECTIVE(S): We propose to test the effectiveness of a multi-faceted patient-centered adherence intervention among veterans following ACS hospitalization to improve adherence to cardioprotective medications (primary aim). Secondary aims will assess whether the intervention improves achievement of secondary prevention blood pressure (BP) and LDL-cholesterol goals, reduces cardiac endpoints (MI hospitalization, coronary revascularization, all-cause mortality) and is cost-effective.
METHODS: We propose a 3-year, multi-site patient-level randomized controlled trial to evaluate, relative to usual care, a multi-faceted patient-centered intervention to improve adherence to cardioprotective medication among veterans following ACS hospital discharge. The study will enroll 280 patients to intervention versus usual care for 12-months at 3 VA Medical Centers (Eastern Colorado, Pudget Sound, and Central Arkansas). The proposed intervention will be based on several conceptual frameworks (Chronic Care Model and Medication Adherence Model) and adapt elements of prior successfully adherence interventions, including: collaborative care, patient education, tailoring of medication regimens, and tele-monitoring. The primary analyses will be a comparison of adherence to cardioprotective medications using pharmacy refill records based on the ReCOMP adherence measure developed in the VA. Secondary analyses will compare achievement of secondary prevention BP and LDL goals and cardiac events. In addition, cost-effectiveness analysis will be performed. All analyses will be intention to treat
|Ages Eligible for Study:
|18 Years to 90 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
All patients admitted with acute coronary syndrome (ACS) as the primary reason for hospital admission and use the VA for their usual source of care, defined as having 1 primary care visit within the 12 months prior to hospital admission will be screened for eligibility to participate. ACS is defined as acute myocardial infarction (both ST-elevation MI and non-ST elevation MI) or unstable angina. The presence of acute myocardial infarction will be defined using standard definitions from an international consensus statement, based on the following: a rise and/or fall of cardiac biomarkers (preferably troponin) with at least one value above the 99th percentile of the upper reference limit and at least one of the following:
- symptoms of ischemia;
- ECG change indicative of new ischemia (new ST-T changes or new left bundle branch block);
- development of pathological Q waves in the ECG; or
- imaging evidence of new loss of viable myocardium or new regional wall motion abnormality.42 Unstable angina will be defined by presence of ischemic symptoms and ECG changes indicative of new ischemia but without biomarker evidence of myonecrosis (i.e., biomarker elevation) and no evidence of new pathological Q waves, loss of viable myocardium or regional wall motion abnormality.
Exclusion Criteria:
- Patient admitted for primary non-cardiac diagnosis and develop ACS as a secondary condition (e.g. perioperative MI);
- planned discharge to nursing home or skilled nursing facility;
- irreversible, non-cardiac medical condition (e.g. metastatic cancer) likely to affect 6-month survival or ability to execute study protocol;
- lack of telephone/cell phone;
- VA is not primary source of care;
- regularly fill medications at non-VA pharmacy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00903032
|United States, Arkansas
|Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR
|Little Rock, Arkansas, United States, 72205-5484
|United States, Colorado
|VA Eastern Colorado Health Care System, Denver, CO
|Denver, Colorado, United States, 80220
|United States, North Carolina
|Durham VA Medical Center, Durham, NC
|Durham, North Carolina, United States, 27705
|United States, Washington
|VA Puget Sound Health Care System, Seattle
|Seattle, Washington, United States, 98108
|Principal Investigator:
|Michael Ho, MD PhD
|VA Eastern Colorado Health Care System, Denver, CO
|Responsible Party:
|VA Office of Research and Development
|ClinicalTrials.gov Identifier:
|NCT00903032 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 13, 2009
|Results First Received:
|December 3, 2014
|Last Updated:
|April 6, 2015
Keywords provided by VA Office of Research and Development:
Additional relevant MeSH terms:
Acute Coronary Syndrome
Pathologic Processes
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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8 Ways to Lose Weight Without Eating Less
Rita Cookson, 43, married 5 years
Lost 29 lbs
How she did it: "I've dropped 29 pounds since starting the challenge four months ago. And if I can do it, anyone can—I'm a pastry chef! Last year at this time, I felt depressed, tired, and generally gross about myself. I am a completely different person today. I stopped eating all those extra cupcakes and cookies, plus I've been doing four fun cardio classes per week at Gold's Gym, in addition to meeting with a trainer there twice a week. I was afraid of lifting heavy weights because I thought I'd bulk up, but I got leaner and feel amazing."
25 Ways to Burn 100 Calories Just Like That


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Please call Above All Art for Prices and Availability on Originals and Giclees of Ringo Fine Art See Art Below
ANDY WARHOL: One of the greatest artists of modern times. Created the POP ART movement.
STEVE KAUFMAN: Assistant to Andy Warhol, still going strong. Currently has art in Museums and major art galleries, both in the USA and internationally. Redefined the POP ART movement.
RINGO: The assistant to Steve Kaufman, is hoping to match their fire.
THE LEGACY CONTINUES..... 22 year old Ringo (Ringo Daniel Funes, wants to be known only as Ringo) has been with Steve Kaufman for many years. Ringo at an early age was part of Steve Kaufman's program GIVE KIDS A BREAK. He is so determined, talented and promising that Steve Kaufman has made him his assistant.
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Murphy could be out past Opening Day
PORT ST. LUCIE, Fla. -- For the first time all spring, the Mets are considering the realistic possibility that second baseman Daniel Murphy will not be ready for Opening Day.
Murphy backed off his rehab program for a second straight day on Sunday, with continued midsection stiffness keeping him off the playing field. Originally scheduled to participate in Minor League games this weekend, Murphy has not seen any action since playing five defensive innings in a Minor League game Friday.
"He's pretty stiff again today, so [trainer] Ray [Ramirez] just said we'd better back him off probably through the day off," manager Terry Collins said, referencing Tuesday's scheduled team off day. "We'll see how he is on Wednesday when we get back."
But time is growing thin. Murphy has yet to appear in a Grapefruit League game due to the strained right intercostal muscle he suffered in mid-February, and will need at least a week's worth of games to prepare for Opening Day.
If he is not ready to play by next weekend, Murphy stands a good chance of beginning the year on the disabled list.
"If he's not back in a game, we're down to seven days," Collins said. "That's not a lot of time to get somebody that hasn't done anything all spring ready."
Should Murphy indeed be unavailable, Justin Turner and Jordany Valdespin are both capable of filling in for him at second. But if the Mets need Turner to play third base in place of David Wright, who is also injured, Collins said Valdespin would open the year as the everyday second baseman.
Originally an afterthought for the Opening Day roster, Valdespin now appears to be a lock -- thanks in part to his .378 spring average and four home runs. If he does not make the team as Murphy's second base sub, Valdespin will serve as a backup outfielder.
Anthony DiComo is a reporter for MLB.com. Follow him on Twitter @AnthonyDicomo. This story was not subject to the approval of Major League Baseball or its clubs.


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The Senate's top Democrat says Republicans are mounting a full-scale filibuster of Chuck Hagel's nomination to be President Barack Obama's secretary of defense.
Majority Leader Harry Reid says Thursday there has never been a filibuster of a secretary of defense in the country's history.
The Nevada senator says it's "shocking" and "tragic" that Republicans would block Hagel's nomination.
Reid filed a motion Wednesday to limit debate and force a vote on Hagel's nomination, which is expected to be held Friday. While Democrats hold a 55-45 edge in the Senate and have the numbers to confirm Hagel on a majority vote, they need the backing of five Republicans to clear the way for an up-or-down vote on him.


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Topic: Is there a "normal" course for this disease?
I am wondering if there is a normal course for this disease? I know that most of us start out with jaundice and itching when we are diagnosed. That is how they discovered my tumor. But what happens in the long run if the tumor can't be removed? Does the cancer usually spread? Does the tumor grow? Or is each person and case different? What eventually causes people to pass away? What helps people live longer? Why is there such a grim 5 year prognosis?
I started out in good health, and have been healthy and took care of myself all my life. So it was a shock to find out I have cancer. However, I think that starting off in good health and relatively young (45) is beneficial.


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The Cedar Keyhole Gallery is proud to announce:
Taking nothing more than the flotsam and jetsam of our native waters and estuaries, Joey Barkhouse has been able to create intricate works of art. A stray rock or piece of driftwood magically transforms into owls or fish. Her carvings and rock paintings have become legend in the area and Joey is willing to work into the night to meet the growing demands of her fans. Ms. Barkhouse will have her latest works on display at the Cedar Keyhole for the entire month of January.
GALLERY HOURS: 10 a.m. to 5 p.m.
The Cedar Keyhole, located on 2nd Street [across from the Library] in Cedar Key, also maintains a display of many other works by over 20 contributors to its artists' cooperative. These works include paintings [oils, acrylics, pastels, and watercolors], metal works, stained glass, jewelry, fiber arts, leatherwork, pottery, and woodworking among others.
For more information, please call "The Keyhole" at [352]543?5801. Please publish this announcement each week during the month of January.
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If you are new to the award winning Chiefland Citizen and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
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The study of Political Science is concerned with the relationship between the governed and the government, the nature of the political process, and the role of the citizen in a democratic society.
Students majoring in political science are required to complete 39 Liberal Arts Core credits, 36 Specific Departmental credits, 16 Departmental Elective credits, and other free electives. Click here to view the complete program requirements.
Students minoring in Political Science are required to complete at least 24 credits in Political Science, exclusive of internship credits. Click here to learn more about minoring in Political Science.


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Banged-up Angels capitalize on error, claim road win
Two-run rally, started by fielding miscue, snaps tie in Chicago
CHICAGO -- Brendan Harris had three hits, J.B. Shuck ignited a couple of runs, and Dane De La Rosa and Michael Kohn combined to provide three scoreless innings of important relief in a 7-5 victory at U.S. Cellular Field on Friday night.
It was the Angels' first set of back-to-back wins since sweeping the Tigers from April 19-21.
And it was a snapshot of where this high-priced, championship-hopeful team is -- hurt, struggling and in need of a boost from unlikely sources in order to keep its head above water.
For one night at least, the 13-22 Angels got that.
"It's huge," Kohn said. "Guys have been hurt, and it's just big for the team when guys like that step up."
This essentially looked like a throwaway game -- if not for the fact that the Angels can't afford to give any more games away.
Scheduled starter Tommy Hanson was gone, back in Georgia to deal with the aftermath of his step-brother's death, setup man Scott Downs was sidelined with a foot injury that he sustained the night before, handcuffing a bullpen that already had three important members on the disabled list, Peter Bourjos is still in Arizona rehabbing a left hamstring strain and Erick Aybar was out of the lineup, one night after hurting his left hamstring.
The man who took the ball, Barry Enright, became the ninth starting pitcher the Angels had deployed this year -- after using eight all of last season.
But with Jerome Williams starting Saturday's game, Garrett Richards back to being a reliever, Jered Weaver still sidelined, the farm system barren and the 40-man roster left with three healthy pitchers who aren't in the Majors -- David Carpenter, Nick Maronde and Ryan Brasier -- the Angels really didn't have anywhere to turn.
Luckily, the offense was there and the bullpen stepped up. They got a four-run third, retook the lead with a two-run seventh, then watched as Kohn (scoreless sixth), De La Rosa (perfect seventh and eighth) and Ernesto Frieri (struck out the side in the ninth) shut it down, giving the Angels back-to-back road wins for the first time all season.
"Those guys stepped up big," manager Mike Scioscia said of his relievers. "I think we had about as good a performance as you can expect."
Shuck hit a sacrifice fly, Albert Pujols added a two-run double and Mark Trumbo notched an RBI single in the third and Aybar's replacement at shortstop, Harris, hit a solo homer for the second straight night in the fourth, giving the Angels an early 5-1 lead.
Enright, who hadn't appeared in a game in 10 days and hadn't pitched more than 2 2/3 innings since April 15, gave up five runs on four hits in 3 1/3 innings. Four of those runs came in a fourth inning that Enright couldn't finish, when he loaded the bases with none out, threw a wild pitch, gave up a double to Dayan Viciedo, then watched Mark Lowe surrender the tying run on a two-out single to Tyler Flowers.
"Guys pitch tired, guys pitch sore -- guys pitch like that all the time," Enright said. "I was a little disappointed it ended that way, throwing that [slider] to Viciedo."
But the Angels re-took the lead in the seventh, when White Sox reliever Matt Lindstrom gave up an RBI single to Mike Trout and then allowed Shuck to score on a passed ball.
"They seemed to just kind of find some holes that inning," Flowers said. "A hard-hit ball here, a double, and a couple of runs scored but for the most part I think it was them kind of finding holes lumped into all that together."
Somehow, the Angels found a way.
They'll need to do a lot of that.
Alden Gonzalez is a reporter for MLB.com. Read his columns and his blog, Gonzo and "The Show", and follow him on Twitter @Alden_Gonzalez. This story was not subject to the approval of Major League Baseball or its clubs.


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Hernandez to make spot start Thursday
CHICAGO -- Having used scheduled Thursday's scheduled starter Tyler Matzek in relief at the end of Tuesday night's 4-3, 16-inning loss to the Cubs, the Rockies are calling up lefty Pedro Hernandez from Triple-A Colorado Springs for the final game of the series.
Hernandez (6-6, 6.16 ERA at Colorado Springs) has appeared in 15 games, including 13 starts, in the Majors with the White Sox (2012) and Twins (2013) and is 3-4 with a 7.57 ERA.
Weiss said Matzek will not be skipped, but his next start will be pushed back.
Thomas Harding is a reporter for MLB.com. Read his blog, Hardball in the Rockies, and follow him on Twitter @harding_at_mlb. This story was not subject to the approval of Major League Baseball or its clubs.


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Movie Review
Rated PG for sequences of fantasy action and violence, including frightening images. One hour, 37 minutes.
Publication date: May. 30, 2014
Review by Peter Canavese
Released: (2014)
If only the film around Jolie were worthy of her. Perhaps "Maleficent" could have been an extraordinary work of art, a la Cocteau's "La belle et la bÍte" had it been approached from a place of confident emotional truth-telling, narrative patience and visual poetry. The work of first-time director Robert Stromberg (a veteran of visual effects and art direction) manages some striking visuals suggesting that direction could have been possible, but even if he were Cocteau, he'd still be up against economics: This Disney picture is as much about brand-building synergy as anything else.
Disney's long struggle to do restitution for its princess-myth years continues by re-imagining Maleficent as an orphan fairy queen (Isobelle Molloy) flying happily about her wooded land as a heroic freedom-fighter, "protector of the moors" from a nearby human kingdom. But when she grows of age to take her crack at love, and experiences as a result a physically violating betrayal that's deeply traumatizing, the full-grown Maleficent (Jolie) turns on a dime to vengeance against the man who betrayed her: King Stefan (Sharlto Copley). This trajectory could make sense, but instead of allowing Maleficent to articulate her pain at any point, we merely get five seconds of Jolie wailing in anguish before she decides black is the new black.
After this origin story (a Hollywood addiction of recent years), "Maleficent" sets to replaying Disney's 1959 "Sleeping Beauty" (itself adapted from Charles Perrault's fairy-tale text "La Belle au bois dormant"). Ironically, "Maleficent" is unarguably at its most arresting in the scene that tinkers least with the source material: when Jolie, newly decked out as the villainous version of Maleficent, sleekly strides up to Stefan's throne and curses his infant daughter Aurora. Jolie has the scene for lunch, and the film comes roaring to life.
She gets a little help from the traditional costume -- with its black drapery and imposing, devilish horns -- and Rick Baker's makeup design, which makes her already formidable cheekbones look like they could get part-time work as meat slicers. But we're not meant to enjoy this display (which prompts the reaction "You're the evil that's in the world") as much as we do, as the film's raison d'etre is to explain Maleficent's humanity. It's a noble cause to reconceive evil -- especially to children -- as just a person you haven't figured out yet, but some classic tales lend themselves more readily to such an approach than others (John Gardner's novel "Grendel" hit the sweet spot).
The screenplay by Linda Woolverton (Disney's "Beauty and the Beast") next sends Maleficent on a journey of remorse for having misdirected her anger onto an innocent. The babe grows into teenage Elle Fanning, whose Aurora mistakes the ever-lurking Maleficent for her fairy godmother. Aurora has a date with a spindle, and maybe with Brenton Thwaites' Prince Phillip for a curse-ending "true love's kiss," but as the narration promises, this story is "not quite as you were told": Archetypal male conquest will lose, and the best of archetypal female power will overcome the worst of it. Plus a CGI dragon.


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Excellence and compassion are our guideposts to your treatment from initial consultation through your recovery.
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Forklift Rental In Osage, Wyoming
If you knew that a form that only takes 30 seconds to complete could save you tons of money and time and would help boost your business or personal productivity, would you be interested in knowing more? Well, you have come to the right place because we are here to take the guess work out of renting a forklift for your project needs for the time frame you want and at the best price possible.
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It would not be compulsory for people who are more comfortable pissing into the tent rather than out of it.
octathlon wrote:How about if there was a way for people who want to "ask a monk/ask a teacher" to submit their questions privately somewhere
retrofuturist wrote:Greetings,octathlon wrote:How about if there was a way for people who want to "ask a monk/ask a teacher" to submit their questions privately somewhere
Which leads me to wonder, given that we don't have a great deal of active monks here, if someone wanted to ask a monk or someone who they viewed as a "teacher", couldn't they just PM the person and ask the question?
I sense the bhikkhus here do not want to be forcibly put up on a pedestal, as this would undermine their Dhammic efforts towards humility and release of mana (conceit). I respect this. If we were to take what is being talked about and consider it analogously to a "meatspace" environment, it's akin a grand assembly, where venerables Appicchato, Pesala and co, are sat up on high, luxurious chairs as individuals come up and circumambulate them and pose questions to them in front of a captive audience, seeking definite Dhamma teaching and instruction. I don't think that's fair on them - who says they want to be distinguished as "teachers", who says their preceptors would even endorse such a thing? It seems awfully problematic to me and whilst it sounds like a nice idea on the surface, I think it's fraught with problems and inconvenience.
I'm just pleased we have here some ordained members who will lend their perspectives when they feel it is appropriate to do so - I think those offerings should be appreciated for what they are.
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A macro is a series of commands that you can use to automate a repeated task, and can be run when you have to perform the task. This article has information about the risks involved when you work with macros, and you can learn about how to enable or disable macros in the Trust Center.
In this article
Enable macros when the Message Bar appears
When you open a file that has macros, the yellow message bar appears with a shield icon and the Enable Content button. If you know the macro, or macros, are from a reliable source, use the following instructions:
On the Message Bar, click Enable Content.
The file opens and is a trusted document.
The following image is an example of the Message Bar when macros are in the file.
Enable macros in the Backstage view
Another method to enable macros in a file is via the Microsoft Office Backstage view, the view that appears after you click the File tab, when the yellow Message Bar appears.
Click the File tab.
In the Security Warning area, click Enable Content.
Under Enable All Content, click Always enable this document's active content.
The file becomes a trusted document.
The following image is an example of the Enable Content options.
Enable macros for one time when the Security Warning appears
Use the following instructions to enable macros for the duration that the file is open. When you close the file, and then reopen it, the warning appears again.
Click the File tab.
In the Security Warning area, click Enable Content.
Select Advanced Options.
In the Microsoft Office Security Options dialog box, click Enable content for this session for each macro.
Click OK.
Change macro settings in the Trust Center
Macro settings are located in the Trust Center. However, if you work in an organization, the system administrator might have changed the default settings to prevent anyone from changing settings.
Important: When you change your macro settings in the Trust Center, they are changed only for the Office program that you are currently using. The macro settings are not changed for all your Office programs.
Click the File tab.
Click Options.
Click Trust Center, and then click Trust Center Settings.
In the Trust Center, click Macro Settings.
Make the selections that you want.
Click OK.
The following image is the Macro Settings area of the Trust Center.
Use the information in the following section to learn more about macro settings.
Macro settings explained
Disable all macros without notification Macros and security alerts about macros are disabled.
Disable all macros with notification Macros are disabled, but security alerts appear if there are macros present. Enable macros on a case-by-case basis.
Disable all macros except digitally signed macros Macros are disabled, but security alerts appear if there are macros present. However, if the macro is digitally signed by a trusted publisher, the macro runs if you have trusted the publisher. If you have not trusted the publisher, you are notified to enable the signed macro and trust the publisher.
Enable all macros (not recommended, potentially dangerous code can run) All macros run. This setting makes your computer vulnerable to potentially malicious code.
Trust access to the VBA project object model Disallow or allow programmatic access to the Visual Basic for Applications (VBA) object model from an automation client. This security option is for code written to automate an Office program and manipulate the VBA environment and object model. It is a per-user and per-application setting, and denies access by default, hindering unauthorized programs from building harmful self-replicating code. For automation clients to access the VBA object model, the user running the code must grant access. To turn on access, select the check box.
Note: Microsoft Publisher and Microsoft Access have no Trust access to the VBA project model object option.
What is a macro, who makes them, and what is the security risk?
Macros automate frequently used tasks to save time on keystrokes and mouse actions. Many were created by using Visual Basic for Applications (VBA) and are written by software developers. However, some macros can pose a potential security risk. A person with malicious intent, also known as a hacker, can introduce a destructive macro in a file that can spread a virus on your computer or into your organization's network.


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We are in Charlottesville VA
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A BUSY year at the Blockley Heritage Society is being brought to a close with an evening of historical music.
Richard Sermon, of The Pipe and Tabor Society, will perform A Whistle and a Wassail All Over the Town on Monday, November 26, at 8pm.
The pipe and the tabor are instruments with a long heritage – the pipe is a one-handed whistle with only two finger holes and a thumb hole, while a tabor is an early drum.
This year the heritage society has made progress on plans to extend its premises to include a permanent exhibition.
Meanwhile improvements have been made to its HQ, including the lining of the roof of the John Malin Library on the first floor to improve storage conditions.
Chairman Robert Willott said: "The society has recruited several volunteers from its membership to help build an oral local history archive by recording interviews with villagers about Blockley's past.
"Plans are also being made to assemble as many stories as possible about Blockley residents who served in the forces or in home defence during the First and Second World Wars, in preparation for the centenary of the outbreak of the First World War and the 70th anniversary of D-Day and the Allied invasion of Normandy."
Society president, Jeremy Bourne, has completed a new and updated edition of H.E.M. Icely's history of the parish – Blockley Through Twelve Centuries – for publication in the new year.


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The New School
Fence Journal Reading with Brandon Downing, Hannah Gamble and Bernadette Mayer
Brandon Downing is a writer and visual artist originally from California. His books of poetry include The Shirt Weapon and Dark Brandon, and a monograph of his literary collages from 1996-2008, Lake Antiquity. A long poem, AT ME, was released by Octopus Books last year, and his latest collection, Mellow Actions, is just out from Fence. He lives in New York City, where he works as an exhibit designer and historian.Hannah Gamble is the author of Your Invitation to a Modest Breakfast, selected by Bernadette Mayer for the 2011 National Poetry Series and to be published by Fence in 2012. Hannah is the Poet-in-Residence at Children's Memorial Hospital in Chicago and also teaches literature classes at Prairie State College in Chicago Heights. Her poems and interviews appear or are forthcoming in APR, Indiana Review, Ecotone, Mid-American Review, and elsewhere.
Bernadette Mayer is the author of numerous books of poetry and prose, including: Poetry State Forest, Scarlet Tanager, Two Haloed Mourners: Poems, Proper Name and Other Stories, The Desires of Mothers to Please Others in Letters, The Bernadette Mayer Reader, Sonnets, Midwinter Day, The Golden Book of Words, and Ceremony Latin. From 1972 to 1974, Mayer and conceptual artist Vito Acconci edited the journal 0 TO 9. With writer and publisher Lewis Warsh, she edited United Artists Press. She has taught writing workshops at The Poetry Project at St. Mark's Church in New York City for many years and she served as the Poetry Project's director during the 1980s.
Moderated by Rebecca Wolff, editor of Fence.
Sponsored by the School of Writing.
Wollman Hall, Eugene Lang Building, 65 West 11th Street, 5th floor (enter at 66 West 12th Street)
Free; no tickets or reservations required; seating is first-come first-served
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North American Study of Epistaxis in HHT (NOSE)
This study has been completed.
James Gossage
Hereditary Hemorrhagic Telangiectasia Foundation International
Information provided by (Responsible Party):
James Gossage, Georgia Regents University
ClinicalTrials.gov Identifier:
First received: August 1, 2011
Last updated: November 5, 2014
Last verified: November 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of the NOSE Study is to carefully examine the efficacy and safety of 3 nasal sprays (bevacizumab, estriol, and tranexamic acid), compared to placebo, for the treatment of HHT related nosebleeds.
|Telangiectasia, Hereditary Hemorrhagic Epistaxis
|Drug: Sterile saline Drug: Bevacizumab Drug: Estriol Drug: Tranexamic Acid
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|North American Study of Epistaxis in HHT (NOSE)
Resource links provided by NLM:
Drug Information available for: Tranexamic acidU.S. FDA Resources
Further study details as provided by James Gossage, Georgia Regents University:
Primary Outcome Measures:
- Frequency of epistaxis [ Time Frame: Weeks 5-12 of active treatment phase ]
Secondary Outcome Measures:
- Duration of epistaxis [ Time Frame: 5-12 weeks of active treatment ]
- Hoag Epistaxis Severity Score [ Time Frame: 12 and 24 weeks ]
- Short Form-36 Health Survey [ Time Frame: 12 and 24 weeks ]
- Supplemental Epistaxis Questionnaire [ Time Frame: 12 and 24 weeks ]
- Hemoglobin level and ferritin levels [ Time Frame: 12 and 24 weeks ]
- Units of RBC transfused [ Time Frame: 12 and 24 weeks ]
- Treatment failure [ Time Frame: Baseline through 24 weeks ]Need for nasal surgery or severe complications such as acute MI, venous thromboembolism, or CNS hemorrhage
|Study Start Date:
|August 2011
|Study Completion Date:
|September 2014
|Primary Completion Date:
|September 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Placebo Comparator: Placebo spray
Drug: Sterile saline
0.9%, 0.1 ml spray in each nostril bid
Other Name: Saline
|Active Comparator: Bevacizumab spray
Drug: Bevacizumab
1% solution in saline, 0.1 ml spray in each nostril bid
Other Names:
|Active Comparator: Estriol spray
Drug: Estriol
0.1% suspension in methylcellulose, 0.1 ml spray in each nostril bid
Other Name: Estrogen
|Active Comparator: Tranexamic acid spray
Drug: Tranexamic Acid
10% solution in saline, 0.1 ml spray in each nostril bid
Other Name: Lysteda
Detailed Description:
140 patients with moderate to severe epistaxis secondary to HHT will be randomized to receive one of four intranasal sprays for a period of 12 weeks and then followed for an additional 12 weeks off therapy. Enrollment will occur over a period of 18-36 months. The primary endpoint will be the frequency of epistaxis. Secondary endpoints will include duration of epistaxis, the Hoag Epistaxis Severity Score (ESS), a quality of life survey, satisfaction with treatment, hemoglobin and ferritin levels, transfusion requirements, and treatment failure. The sprays will be: saline spray (Placebo); estriol 0.1% in methylcellulose suspension (EST); tranexamic acid 10% in saline (TA), and bevacizumab 1% in saline (BEV). All sprays will be applied to the nasal mucosa by an identical spray bottle at a dose of 0.1 ml per nostril twice daily (total dose of 0.4 ml daily). Thus, the delivered doses will be: EST, 0.4 mg/day; TA, 40 mg/day; BEV, 4 mg/day.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
A diagnosis of definite or possible HHT by the Curacao criteria (Shovlin 2000) or a positive DNA test for HHT (as characterized by a disease causing mutation in the gene coding for endoglin, ALK-1, or SMAD-4). According to the Curacao criteria, a definite diagnosis of HHT is defined as having at least 3 of the following criteria while a possible diagnosis is defined as 2 criteria:
- Spontaneous and recurrent epistaxis.
- Multiple telangiectasias at characteristic sites (lips, oral cavity, fingers, nose).
- Visceral lesions such as gastrointestinal telangiectasias and arteriovenous malformations (AVM) in lung, brain, spine and liver.
- A history of definite HHT in a first degree relative using these same criteria.
- Epistaxis of at least 1 minute (on average) and which occurs at least once weekly when averaged during the preceding 8 weeks.
- Epistaxis severity score (ESS) of at least 3.0.
- Age of at least 18 years.
- Written and informed consent obtained prior to study entry.
- Subject is able and willing to return for outpatient visits.
- The epistaxis is considered to be clinically stable during the past 8 weeks in the clinical judgment of the investigator (i.e. no major changes in frequency or duration of epistaxis or in transfusion requirements).
- Negative pregnancy test at enrollment.
Exclusion Criteria:
- Allergy to any of the active treatment agents or their spray additives.
- Estimated life expectancy less than 1 year.
- A psychiatric or substance abuse problem that is expected to interfere with study compliance.
- History of deep venous thrombosis (DVT), pulmonary embolism (PE), acute myocardial infarction (MI), arterial thromboembolism, or ischemic stroke in the past 6 months.
- History of estrogen receptor positive breast cancer.
- History of receiving more than 12 units of red blood cells in the past 12 weeks.
- Presence of an untreated coagulopathy that is felt to be contributing to the epistaxis.
- Presence of active disseminated intravascular coagulation.
- Uncontrolled hypertension (SBP >160 and/or DBP >100).
- Presence of untreated brain AVM.
- Presence of active malignancy in the brain, lung, or colon.
- Presence of symptomatic heart failure.
- Use of estrogens, epsilon aminocaproic acid, tranexamic acid, or thalidomide by any route for more than 1 week in the past 12 weeks. Any use of a VEGF inhibitor by any route in the past 24 weeks.
- Baseline use of the following anticoagulants is not allowed: warfarin or other vitamin K antagonists at any dose; unfractionated or low molecular weight heparins at standard doses for treatment of venous thromboembolism (VTE); or aspirin at >325 mg/day. Baseline use of the following anticoagulants is allowed: heparins at standard doses for VTE prophylaxis; clopidogrel; or aspirin at ≤325 mg/day.
- Addition of new treatments for epistaxis in the past 12 weeks (including laser ablation of nasal telangiectasias and over the counter medications).
- Presence of another overt cause (e.g. overt gastrointestinal bleeding) that is felt to be significantly contributing to anemia.
- Lactating women.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01408030
Please refer to this study by its ClinicalTrials.gov identifier: NCT01408030
|United States, California
|University of California Los Angeles
|Los Angeles, California, United States, 90095
|United States, Georgia
|Georgia Regents University
|Augusta, Georgia, United States, 30912
|United States, Maryland
|Johns Hopkins University
|Baltimore, Maryland, United States, 21205
|United States, Missouri
|Washington University School of Medicine
|St Louis, Missouri, United States, 63110
|United States, Oregon
|Oregon Health Sciences University
|Portland, Oregon, United States, 97239
|United States, Utah
|University of Utah
|Salt Lake City, Utah, United States, 84132
Sponsors and Collaborators
James Gossage
Hereditary Hemorrhagic Telangiectasia Foundation International
|Principal Investigator:
|James R Gossage, MD
|Augusta University
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by James Gossage, Georgia Regents University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Whitehead KJ, Sautter NB, McWilliams JP, Chakinala MM, Merlo CA, Johnson MH, James M, Everett EM, Clancy MS, Faughnan ME, Oh SP, Olitsky SE, Pyeritz RE, Gossage JR. Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial. JAMA. 2016 Sep 6;316(9):943-51. doi: 10.1001/jama.2016.11724.
|Responsible Party:
|James Gossage, Director of Pulmonary Vascular Diseases and HHT, Georgia Regents University
|ClinicalTrials.gov Identifier:
|NCT01408030 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 1, 2011
|Last Updated:
|November 5, 2014
Keywords provided by James Gossage, Georgia Regents University:
tranexamic acid
Additional relevant MeSH terms:
Telangiectasia, Hereditary Hemorrhagic
Vascular Diseases
Cardiovascular Diseases
Nose Diseases
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
Pathologic Processes
Hemostatic Disorders
Hemorrhagic Disorders
Hematologic Diseases
Vascular Malformations
Cardiovascular Abnormalities
Congenital Abnormalities
Tranexamic Acid
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
Antineoplastic Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Antifibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017