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http://www.prosportsdaily.com/commen...7-28-2008.html"The slowest part of the NBA offseason is approaching.
There are several restricted free agents- Emeka Okafor, Josh Smith and Ben Gordon for example - that have yet to land new contracts, but most of the major offseason moves have already taken place.
The Pacers got their work done in a two-day period in late June.
They're still looking for a new home for point guard Jamaal Tinsley.
That matter may not be resolved until training camp starts in late September.
With that, I'll give you an update on a few tidbits.
--I talked to a person in the organization last week who said Tinsley continues to drop pounds. I still haven't been able to pinpoint the exact number of pounds Tinsley put on. I was told it was more than 20 late in the season.
Pacers president Larry Bird added new wrinkle into things last week when he said he doesn't believe in buying out contracts.
"I think these guys should earn their money. If you can't trade them, let them stay at home," he said on AM-1070. "We're in some situations here where the same people continue to get in trouble. We have to deal with it. We'll deal with it the way we think is appropriate."
A fellow beat writer and I got into a discussion about Tinsley last week. I threw out the notion of what if the Pacers can't find a taker for Tinsley and he's completely in shape by the start of training camp.
The writer said there's no way Tinsley can wear a Pacers uniform again.
I responded, "I don't see Tinsley wearing a Pacers uniform again, especially after some of the comments Bird and coach Jim O'Brien made in the past month, but Bird did say players should earn their money."
Im just glad hes out. From the article, its fair to assume that theres going to be some sort of shake up (considering that Tinsley wont be a Pacer and Bird doesnt beleive in buy outs)


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Topic: Long overdue update
Greetings all,
I've been remiss in not keeping up with the board here. I think of everyone here all the time and have been dealing with my own ups and downs of this disease.
I now have a blog which I'm using to keep friends and family more up to date with what is happening for me. If you're interested it is available at:
I have not been able to keep solid foods down for about 2 months now. What follows is my most recent post on this blog. A search on this site for Dr Jenkins will turn up a number of hits with more information.
love and courage to all
his is a long post. If you'd like the short version you can just read the first paragaph.
Dr Jenkins feels my recurrent disease is slowly progressing as it has been for a few years now. The difficulty eating is a result of this progression but any decision on surgery to relieve this symptom is entirely my choice. While there are no guarantees I have lived well with recurrent disease for years now and there is no reason to believe I should not be able to continue this for some time although the current symptom with food and liquid will get worse over an unspecified time.
My unpolished notes from today's visit:
Oct 1, 2008
Decisions are mine now.
Common sense and experience support that the blockage is the moss, spilled paint, tumor that Roger has suspected since at least 2006.
He reminded me that I was having some gastric distress since 2006. His notes from my visit then confirm this. He feels this is just the slow extension of this problem. He does not buy that the cancer has morphed to non-differentiated but that it is the same, slow growing, differentiated tumor moss that I have dealt with (WELL!) for years now.
He was careful with his words but felt that the Hitchcock docs were experimenting unnecessarily. He stated that the cholangiograms were unnecessary and unsupported. In his opinion there is no need for a cholangiogram unless the patient is badly jaundiced which I was not. I endured 3 of them.
He also stated flat out that he does not believe I have sorosis of the liver. I do have portal hypertension and this is what is driving the DHMC /Berk assumption of sorosis.
Nor does he feel that the end is near although we can never know. He does not believe any investigatory scopes are worth doing. His gut, experience, & observation of 100's of patients does not require additional invasion of my abdomen.
So surgery, and all process decisions, are in my hands. He worried that the docs at Hitch were pushing me unnecessarily toward a decision that may not be right and is only mine to make.
1. I have been living well with recurrent disease for a considerable time and there is no reason to believe I will not be able to for a good while longer. For the first time he related the story of a patient of his who is 15 years out. Never done chemo, recurrent disease for most of that time, 3 surgeries to remove uterus, bladder and something else but still some (restricted) but decent quality of life. I do not have to decide quickly unless I get to a point where I can't maintain the weight I'm at now or can't pass anything. He would then do immediate surgery. No prior tests or extra visits. Just call Julie (his assistant ) and she gets me admitted immediately.
2. Roger was not especially concerned about risks with by-pass surgery. It requires good surgical procedures, staying away from known trouble spots like my varicies and experience with the surgery being performed. He talked about staying focused and not making the one little mistake that can lead to another mistake etc. I liken this to the risk of winter or high altitude mountaineering. It isn't always a major event that causes tragedy but rather a small mistake that can lead to another in a situation where recovery from a mis-step is difficult if not impossible. Moral: Know and trust your fellow climbers and only venture out with those you do trust. Stay mindful and very present.
3. Recovery: A successful surgery would keep me in the hospital about a week and then there would be the recovery time at home. Could be up to a couple of months to get back to a strong and vigorous state. Also the stomach doesn't always just accept that there is a new pathway for food. Sometimes this takes a while.
I talked about not feeling prepared to make the decision. My quality of life is quite good most days now. Being able to eat and still have this quality of life would only be better. And in fact it could be much better as I could gain weight, strength and vigor.
On the other hand I don't want to give up what could be a couple of good months if my life expectancy is only a few more months. Roger repeated that only I can decide. I should take care not to allow myself to be pushed into something by the Docs who know less then I about how I feel and perhaps what is happening with me. There are no guarantees of course but, in his opinion, no reason to believe my life is close to the end either.
He also said that often we know when it is the right time. Like a woman having contractions knows it is time to give birth to her baby.
I expressed my reluctance to consider using chemo again and he supported this decision. He noted that I'd tried it, that it may well have helped me but that he would not encourage me to do it again now.
So it's up to me. Sure would be nice to eat pasta, sure do enjoy so many of my days right now.

subset: commoncrawl


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Decorative Sconces Collection by Holtkotter
Maximize any decorative style with lighting fixtures from the Decorative Sconces Collection by Holtkotter. This collection features three lamps, in a plethora of color schemes. Choose between brass, chrome, stainless steel, titanium silver, and polished nickel finishes, with indigo blue, magma red and Terracotta glass shades. Enhance interior styling by getting a fixture from this elegant collection.


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Why do I have to purchase homeowners insurance in order to obtain a mortgage?
Your home is the collateral for the mortgage loan you're obtaining, so until you pay your mortgage in full, your lender has a financial interest in your property. As a condition of making the loan, your lender will require you to purchase a certain amount of homeowners insurance that will protect both you and the lender in the event that your home is damaged or destroyed.
Generally, at the closing or a few days before closing, you'll be asked to submit proof of coverage, with the lender named as loss payee. If you have any questions, ask your mortgage lender or your insurance company or agent for more information about what's required.


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Topic: mets to lung and lymph nodes
this week has not been good. My Dad's DT scan (only 5 months post resection) is showing enlarged lymph nodes and nodules in 1 of the lungs. He is going to start chemo within the next couple of weeks, he has been offered gemcitabine and carboplatin. (see my posting under chemo for more info). Would really appreciate it if anybody has similar experience of mets post resection and could share their experiences.
Also my Dad has pain and discomfort in his back and abdominal pain is getting worse, the offending lymph nodes are near the kidney so this accounts for the back pain. any experiences/ techniques that have helped?


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|Submitted By:
|John McNamee on Mar 2, 2006
|Comments on Gunnison
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Comments displayed oldest to newest — Skip Ahead to the Most Recent Dated Aug 14, 2013
By Joseph Stover
From: Batesville, AR
May 4, 2006
Are there any guidebooks with information about sport climbing and/or bouldering near Gunnison and Crested Butte? Where is the nearest limestone with lots in the 5.8-5.11, V0-V6 range? I was looking at the crags near Canon City and they look nice, is that a reasonable drive from Gunnison?
Any info is greatly appreciated.
By ropeless420
From: evergreen , co.
May 6, 2006
|Hey Joe, Gunnison is a great place to climb. There are a couple of guides out, bouldering the G spot and unknown are both great. If you need a little help, go see Andy at All Sports Replay, he's a good guy and he knows the area. Sorry but gunny doesn't have any limestone, Shelf Road is the closest. Good luck.
By aaron voreis
Apr 12, 2007
Rock n Roll Sports in Gunnison (970-641-9150) has FREE climbing guides for most of the local areas including the Ultra Sick God's Crag which features stellar bolt clipping on pocketed tuff from 5.9-5.13+. Rock n Roll also has super beta on the Black Canyon, Taylor, The Point, Spring Creek, tons of Bouldering areas, etc...
Gunnison is the most under-rated climbing area in all of Colorado.
By John Peterson
Apr 13, 2007
> Gunnison is the most under-rated climbing area in all of Colorado.
You mean all the routes are super-sandbagged? :-)
Tell Sharp End to get off their ass and print up Leo's book!
By John Peterson
Sep 21, 2007
It's finally out. Hundreds of new routes on my todo list now. Congrats to Leo on finally getting the guidebook published!
The book includes all those hardcore sport routes up at God's Crag along with tons of stuff in Taylor and Spring Creek canyons.
By phil broscovak
Oct 2, 2007
|OK, about time now where do I get a copy here in the backwoods of Boulder?????
By Ben Kiessel
Oct 29, 2007
Here you go Phil:
By Lee Jenkins
From: Tucson, Arizona
Aug 17, 2008
I climbed at "The Point" near Powderhorn over the weekend and am looking for some beta. There is a new route on the east end of the south face that climbs a roof (1st route you come to). Anyone know what the rating is? I thought it was .10a but it felt way harder!
I was sorry to see that this little Crag was left out of Leo's book (which I own) but can understand that he was busy getting the damn thing published. Thanks Leo for a job well done!
By Luke Mehall
From: Durango, Colorado
May 12, 2009
Hey everyone,
I'd like to extend an invitation for everyone to check out 24 Hours of Gunnison Glory, the first 24 hour climbing festival in the west. It will be at Hartmans on the 27th and 28th of June.
Also this same weekend is the Gunnison Loco Motive, Adventure Sport race: 5 miles of kayaking, 26 miles of mountain biking at Hartmans, and a 10k run. (or half that). This is all held in conjunction with the Gunnison River Festival.
Check our website(s) at:
or give me (Luke) a call 970-943-7053 or email: email@example.com
By Allen Hill
From: FIve Points, Colorado and Pine
Jun 11, 2010
|I'm going climbing Taylor Canyon next week! It's been twenty years... so fired up! (as Doug would say)
By YDPL8S
From: Santa Monica, Ca.
Jun 12, 2010
|I'm really jealous, take a run up Dunn's and Left Hand for me.
By dan humphrey
Sep 10, 2010
|I will be in Gunnison this weekend Sep 11. Anyone around for climbing at Hartman's? Dan (415) 845-7363.
By phil broscovak
May 18, 2011
Hey, all you Gunnystoners and Crusted Buteations, HEADS UP! Two remarkable shows at Neptune's. Thur. 5/19 8p Jorge & Joanne Urioste on the Early Days of climbing at Red Rock Nevada AND Fri. 5/20 7p A Tribute to Gunnison's own John (the Gambler) Rosholt.
If you can, try to be there. Check the News or Neptune's site for more info.
By phil broscovak
Aug 14, 2013
|Hey Gunnistoners & Crusted Butteations, I'm going to be in the area (camping at Granite campground by the 1st buttress) for the next few days. Head up and say hi, and perhaps tie in.


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Madison Stern
Not just anybody gets a "mazel tov" from the president of the United States. This somebody is Madison Stern, a 16-year-old from Voorhees, N.J., who received a President's Volunteer Service Award this past March. The award, presented by The Prudential Spirit of Community Awards program, recognizes teenagers who have performed outstanding volunteerism. Stern certainly fits the bill: In two years, she spent 500 hours doing tikkun olam work in three countries.
"I can list all of the activities I did," Stern says in a quiet, polite voice, "but it might take a while. Is that OK?"
It's more than OK, because when Stern describes her volunteer work, she speaks not of herself, but of the people she met and helped. "Most of them were children," Stern says, "who just want the opportunity to make their lives better."
Here's how Stern did that. In Israel, she spent two weeks at The Jaffa Institute helping to feed hungry families. In Costa Rica, Stern spent two weeks running a leadership camp for underprivileged children. In Philadelphia, she volunteers at the Center City Lubavitch house. In South Jersey, Stern tutors Thursday afternoons at Beck Middle School and teaches the kindergarten class at Congregation Beth El on Sunday mornings. During the summer, Stern works with the Ronald McDonald House and, during the winter, she helps organize the Cherry Hill Police Department's holiday party for kids with disabilities.
When she was called to the principal's office at Cherry Hill East High School, Stern had no idea that she was about to receive a certificate and letter from President Barack Obama. She had applied for a scholarship from Prudential and the organization was so impressed with Stern that they nominated her for the award. "I guess 500 hours is a lot," Stern says, "but there are so many people who need help that it's just a drop in the bucket."


text: Kanawha reports very little damage from superstorm By Travis Crum December 7, 2012 Story Share CHARLESTON, W.Va. -- Only a handful of government agencies and even fewer individual families in Kanawha County reported damages from superstorm Sandy, officials said Friday.County representatives met with Peg Kemler, project specialist for the Federal Emergency Management Agency, to learn more about claiming any storm-related damages and expenses that towns, fire departments and other agencies in the county accrued from Oct. 29 to Nov. 8.Kemler said FEMA would reimburse agencies for expenses related to snow removal, debris cleanup, overtime pay for employees and structural damage.Many agencies, however, did not have a lot to report, said C.W. Sigman, Kanawha County's fire coordinator and deputy emergency manager.No agencies present during Friday's meeting reported damage to government buildings and no fire department representatives attended.Most agencies would only have claimed the use of generators during the snowstorm that resulted from what was initially Hurricane Sandy, he said.St. Albans Mayor Dick Callaway said he's claiming the use of several generators that were used to power water and sewage utilities and the Hansford Senior Center.FEMA does not reimburse the cost of fuel, but pays out a usage rate based on the generator's kilowatt voltage, Kemler said. "What we need is a log sheet from the time and date you turned [the generator] on and the time and date you turned it off," she said.Kemler said agencies have 30 days from Friday to make FEMA aware of claims. The sooner those agencies file their claims, the quicker they'll get money, she added.Sigman said it's important for people to understand that FEMA is not providing money for families."There is no individual assistance declaration, but were trying to get one," he said.Residents in Kanawha and multiple other counties will receive individual assistance tied to the June 29 derecho windstorm, but none yet has been declared for Sandy."If you do have damage, call and let us know," Sigman said. "We're not promising you anything, but we can get that recorded so we can try and get you some money."Sigman said Kanawha County residents could call if they ran a generator for medical reasons, bought an oxygen concentrator, lost wages from closed businesses or filed insurance deductibles for structural damage. To report an individual claim, call Kanawha County Homeland Security and Emergency Management at 304-357-0570.Reach Travis Crum at email@example.com or 304-348-5163. Story Share Story Share Trending Now 1 Deer in 8 WV counties found dead from EHD 2 New company planning $73M synthetic fuel plant in Greenbrier County 3 Philanthropist Betty Schoenbaum of Shoney's fortune turns 100 4 On file: Sept. 24, 2017 5 WVU law professor announces run for Congress A truckload of charity (photos) Previous Story W.Va. man gets life without parole in shooting Next Story


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Hurricane Sandy Leaves Her Mark On The East CoastHurricane Sandy could be the storm of the century with the swath of flooding, damage, and mayhem she has wrought on the East Coast of the US. Check out these stunning images of the storm.
Ways You Can Help Storm Victims On The East CoastIf you are looking for ways you can help those affected by Hurricane Sandy, here are a few thinkgs you can do here at home that will help across the miles.


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The noblest pleasure is the joy of understanding.
- Leonardo da Vinci
The greatest deception men suffer is from their own opinions.
Nothing strengthens authority so much as silence.
Human subtelty will never devise an invention more beautiful, more simple or more direct than does Nature, because in her inventions, nothing is lacking and nothing is superfluous.
Since the theory of evolution gained widespread acceptance in the late 1800s,
scientists and philosophers have been searching for ways to relate evolution to
how we live, how we interact with society, and how we think about our place in existence.
All of this has been controversial and problematic. Not only does evolution
clash with popular creation myths, but in the first half of the 20th century,
we saw how evolutionary ideas could be manipulated by powerful political interests
to increase social discrimination and bring about destructive outcomes.
Since then, despite some very thoughtful contributions, evolutionary philosophy
has remained an under-appreciated branch of philosophy. For a long time, evolution
was ignored by academic philosophers and social scientists as though 'where we came from'
had no influence on 'who we think we are' or 'how we should live'.
However, recent advances in biological science, along with the appearance of
aggressive new forms of creationism, have forced many academic philosophers and social
scientists to decide whether they are prepared to defend evolutionary theory, and this
is leading to a resurgence of interest in evolutionary philosophy.
Of particular interest are questions like ... how much of an influence does evolution
have on human behavior? And what are the philosophical implications of evolution on
issues that relate to ethics and morality?
This is not an evolution vs creation debate website.
It assumes that evolution is a fact, but that the theory is still being developed,
and that there are still many important questions that need to be answered before
evolution can mature into a comprehensive philosophy of life.
• Evolutionary theories of aging
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The Journal of Evolutionary Philosophy is currently under development.
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If you would like to assist our editorial team,
if you know of any unlisted websites with relevent information,
or if you would like to publish your own article on this website,
then please
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I have been playing disc golf for over a year now and have been on the same distance plateau for about 9 months. I have tried to read through the articles here but there is so much information, and much of it seems contradictory or eludes my understanding, so I thought I would reach out for some help.
Is there anyone from the Pittsburgh area, who really knows how to throw a driver consistently over 400' AND knows how to teach, willing to work with a fella stuck around the 320s?


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All Android applications categories
Published: 2012-11-15, by Ana Gracia.
Welcome to Pocket Jewels, another incursion in the genre of jewel games and colorful puzzle games. Match as many same-colored jewels as you can in 60 seconds.
First of all, choose your preferred grid size, three desired power-ups to help and then begin to swap the jewels between them in order to obtain big groups of similar ones and start creating combos. You will see it's easy and comfortable, just use your finger and be quick. There are various power-ups to choose and you can select the ones you prefer every time you start a new game, trying them all and changing them when needed.
And yes, it's another jewel application but it's one good entertainment that have kept us addicted for a very long time. We always go back and play this little puzzle games, perfect for traveling by public transport or waiting rooms.
NomNomNom is the developer of Pocket Jewels HD Free and premium version. Good graphics and a known gameplay that still has a lot of success. Download it and have fun getting combos!
Tags: pocket jewels hd free apk , pocket jewels game , pocket jeweled game , pocket jewels puzzle game , is pocket jewels the same as bejeweled
by Ana , Appszoom
Nov 15, 2012
from 3.157 reviews
Download Pocket Jewels HD FREE
Free - 1.0.3 - 15M
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This app is no longer available.Explore Android
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Fruity goodness from North American organic orchards and berry patches nestled in a quaint, 11.5 inch, two handled wicker basket trimmed with adorable apple designs. Six delicious, nutritious, sodium free fruit offerings: old fashioned organic Apple Butter and organic Apple Strawberry Sauce without refined sugars, coloring agents, or preservatives; tart and sweet organic Cherry Juice Concentrate made from Montmorency cherries (also known as 'healing' cherries); and three dried fruits - low bush organic Wild Blueberries, organic Cranberries, and organic and 'transitional-to-organic' Montmorency Cherries sweetened only with organic apple juice concentrate and no additives. All great for baking, snacking, and enhancing your day.
Grandma heartily approves. All fruits are prepared the old fashioned way with no short cuts, chemical processes, refined sweeteners, artificial colors, preservatives, or sulfites. Just simply delicious, good for you fruit with no salt added. All great for use in cooking, baking, or just anytime snacking.
The EDEN Fruit Basket offers six items from North American family organic orchards and berry patches nestled in a quaint, 11.5" by 8.5" two handled wicker basket trimmed with adorable red apple designs. In each basket:
EDEN Organic Apple Butter - A select blend of Great Lakes area organic apple varieties, over four pounds of peeled and cored apples per jar, slowly kettle cooked to a thick spread with a bit of organic apple juice concentrate. A versatile, tangy sweet spread. Sodium free, no additives. What better way to start the day than with real pure old fashioned fruit butter on your toast, bagel, muffin, waffle, or pancakes.
EDEN Organic Apple Strawberry Sauce - Our apple sauce blended with small northern Michigan strawberries, family organically grown. Its soft pink color is from perfectly red ripe strawberry puree. Enticing strawberry fragrance and flavor. No sugar or salt added. Quick, simple, delicious dessert or snack. Great for making moist muffins, cakes, and other baked goods.
EDEN Organic Cherry Juice Concentrate - Michigan family orchard Montmorency tart cherries reduced to a tangy sweet syrup. Reconstitute to taste, 6 or 7 to 1. Delicious cherry pie flavor for beverages, smoothies, sauces, salad dressing, desserts, pastries, pancakes, and waffles.
EDEN Montmorency Dried Tart Cherries - Michigan organic and 'transitional-to-organic', infused with organic apple juice concentrate, slowly dried and misted with high oleic organic safflower oil to prevent clumping. Traditionally known as the 'healing cherry'. Contains 17 powerful antioxidants with no refined sugars or additives.
EDEN Organic Dried Wild Blueberries - Canadian hand harvested and naturally dried with no refined sugars or additives. Sweetened with a bit of organic apple juice concentrate, slowly dried and lightly misted with organic sunflower oil to prevent clumping. Wild, low bush blueberries are rated #1 on the USDA's list of the most potent food sources of antioxidants. Very low sodium with no salt added. Rich in fiber.
EDEN Organic Dried Cranberries - Canadian, native North American variety long valued for its healthy antioxidants. Hand harvested, infused with organic apple juice concentrate, slowly dried and misted with organic sunflower oil to prevent clumping. No refined sugars or additives. Naturally low sodium with no salt added.
Recipes - 40 page Easy EDEN Recipe Booklet.
|Fruit Basket
|Item Number
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- 1 US home use consumer test among 105 women over 2 weeks.
- 2 Based on a US home use consumer test on 105 women aged 18-65 over 4 weeks.


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Putz playing catch, return still undetermined
PHOENIX -- D-backs closer J.J. Putz has begun playing catch, but the closer knows that he still has a ways to go before he's able to pitch again.
Putz was placed on the disabled list with a sprained ulnar collateral ligament on May 8 and recently began playing catch from 90 feet.
"It feels really good," Putz said. "It's fun to watch the team win, but it's hard to not be out there competing with the guys."
The D-backs have stayed away from putting a timetable on a possible return for Putz.
"It's still too far out to even like figure out games and stuff," Putz said. "But we're definitely progressing in the right direction."
Heath Bell has done a nice job in the closer's role since Putz got hurt.
"They're playing well right now, so hopefully I can be like a big acquisition at some point," Putz said.
Steve Gilbert is a reporter for MLB.com. Read his blog, Inside the D-backs, and follow him on Twitter @SteveGilbertMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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Safety Study of AMG 386 to Treat HER2-positive Locally Recurrent or Metastatic Breast Cancer
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: December 11, 2008
Last updated: October 30, 2015
Last verified: October 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to determine if AMG 386 in combination with either paclitaxel and trastuzumab or capecitabine and lapatinib is safe and well tolerated in subjects with HER2-positive locally recurrent or metastatic breast cancer.
This is an open-label phase 1b trial and has 2 study parts. Study part 1 is a dose escalation study to determine a tolerable dose of AMG 386 in combination with paclitaxel and trastuzumab (cohort A) or with capecitabine and lapatinib (cohort B). Study part 2 is cohort expansion of the tolerable doses determined in part 1.
|Breast Cancer Breast Neoplasms Breast Tumors Cancer Locally Recurrent and Metastatic Breast Cancer Metastases Metastatic Cancer Oncology Solid Tumors Tumors
|Drug: AMG 386 30 mg/kg, Paclitaxel and Trastuzumab Drug: AMG 386 30 mg/kg, Capecitabine and Lapatinib Drug: AMG 386 10 mgkg, Paclitaxel and Trastuzumab Drug: AMG 386 10 mg/kg, Capecitabine and Lapatinib
|Phase 1
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|An Open-Label Study of AMG 386 in Combination With Either Paclitaxel and Trastuzumab or Capecitabine and Lapatinib in Subjects With HER2-positive Locally Recurrent or Metastatic Breast Cancer
Resource links provided by NLM:
Genetics Home Reference related topics: breast cancer
MedlinePlus related topics: Breast Cancer
Drug Information available for: Capecitabine Trastuzumab LapatinibU.S. FDA Resources
Further study details as provided by Amgen:
Primary Outcome Measures:
- Primary objective is to identify the incidence of adverse events and clinical laboratory abnormalities defined as a dose limiting toxicity in subjects treated with AMG 386 plus paclitaxel and trastuzumab or with AMG 386 plus capecitabine and lapatinib [ Time Frame: 24 months ]
Secondary Outcome Measures:
- To evaluate the incidence of adverse events and clinical laboratory abnormalities not defined as DLTs [ Time Frame: 24 months ]
- To evaluate the pharmacokinetics (PK) of AMG 386, trastuzumab, and paclitaxel (cohort A) or AMG 386, lapatinib, and capecitabine (and its active metabolite, 5-FU; cohort B) when administered in combination [ Time Frame: 24 months ]
- To estimate the incidence of anti AMG 386 antibody formation [ Time Frame: 24 months ]
- To evaluate the treatment effect as measured by the following: objective response rate (ORR), duration of response (DOR), change in tumor burden and progression-free survival (PFS) [ Time Frame: 23 months ]
|Study Start Date:
|March 2009
|Study Completion Date:
|October 2015
|Primary Completion Date:
|February 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Cohort A1
Drug: AMG 386 10 mgkg, Paclitaxel and Trastuzumab
AMG 386 10 mg/kg IV QW, paclitaxel 80 mg/m2 IV QW, trastuzumab: initial dose 8 mg/kg IV week 1, then 6 mg/kg IV Q3W
|Experimental: Cohort A3
Drug: AMG 386 30 mg/kg, Paclitaxel and Trastuzumab
AMG 386 30 mg/kg IV QW, paclitaxel 80 mg/m2 IV QW, trastuzumab: initial dose 8 mg/kg IV week 1, then 6 mg/kg IV Q3W
|Experimental: Cohort B1
Drug: AMG 386 10 mg/kg, Capecitabine and Lapatinib
AMG 386 10 mg/kg IV QW, capecitabine 2000 mg/m2 divided into 2 doses given PO Q12 hrs, days 1-14 every 21 days, lapatinib 1250 mg PO QD
|Experimental: Cohort B3
Drug: AMG 386 30 mg/kg, Capecitabine and Lapatinib
AMG 386 30 mg/kg IV QW, capecitabine 2000 mg/m2 divided into 2 doses given PO Q12 hrs, days 1-14 every 21 days, lapatinib 1250 mg PO QD
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- histologically or cytologically confirmed adenocarcinoma of the breast with locally recurrent or metastatic disease not amenable to any local treatment with curative intent.
- HER2-positive by FISH, CISH, or IHC 3+
- ECOG performance status 0 or 1
- Left ventricular ejection fraction greater than or equal to institutional lower limit of normal
- Adequate laboratory studies (hematological, chemistries and urinalysis)
- Life expectancy greater than or equal to 3 months
- Cohort A only:
- Trastuzumab naïve or trastuzumab in the neo-adjuvant setting
- No clinically significant drop in cardiac function prior exposure to trastuzumab
- No prior chemotherapy for metastatic or locally recurrent breast cancer
- No prior lapatinib therapy
- At least 3 weeks from enrollment since prior chemotherapeutic agents, including taxanes, in the neoadjuvant or adjuvant setting
- At least 3 months from enrollment since prior trastuzumab in the neoadjuvant or adjuvant setting
- Cohort B only:
- Must have failed trastuzumab in the first-line metastatic setting. Trastuzumab must be discontinued for at least 3 weeks prior to enrollment
- Must have received prior chemotherapy as adjuvant therapy or for metastatic disease
- Prior chemotherapy treatment must be discontinued for at least 3 weeks prior to enrollment
- No prior capecitabine
- No prior lapatinib
Exclusion Criteria:
- Inflammatory breast cancer
- Central nervous system metastasis
- Clinically significant cardiovascular disease
- Radiation therapy ≤ 14 days prior to enrollment.
- Concurrent anticoagulation therapy, excluding aspirin, anti-platelet agents, low molecular weight heparin or low dose warfarin per protocol.
- Uncontrolled hypertension defined as diastolic blood pressure > 90 mmHg OR systolic blood pressure > 140 mmHg.
- Subjects with a history of prior malignancy, except:
- For Cohort B only:
- Current or prior history of long QT syndrome
- Baseline ECG report of QTc interval of > 480 milliseconds
- Severe chronic liver disease (Child Pugh C)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00807859
Please refer to this study by its ClinicalTrials.gov identifier: NCT00807859
|United States, Arizona
|Research Site
|Tucson, Arizona, United States, 85724
|United States, Florida
|Research Site
|Boca Raton, Florida, United States, 33428
|United States, Iowa
|Research Site
|Iowa City, Iowa, United States, 52242
|United States, Massachusetts
|Research Site
|Boston, Massachusetts, United States, 02111
|United States, Minnesota
|Research Site
|Minneapolis, Minnesota, United States, 55407
|United States, New Hampshire
|Research Site
|Lebanon, New Hampshire, United States, 03756-0001
|Research Site
|Lebanon, New Hampshire, United States, 03756
|United States, New Mexico
|Research Site
|Albuquerque, New Mexico, United States, 87131
|United States, New York
|Research Site
|Great Neck, New York, United States, 11021
|Research Site
|New City, New York, United States, 10956
|Research Site
|New York, New York, United States, 10032
|Research Site
|Nyack, New York, United States, 10960
|United States, Ohio
|Research Site
|Middletown, Ohio, United States, 45042
|Research Site
|Leuven, Belgium, 3000
|Research Site
|Liege, Belgium, 4000
|Research Site
|Wilrijk, Belgium, 2610
|Research Site
|Bordeaux, France, 33075
|Research Site
|Caen Cedex 05, France, 14076
|Research Site
|La Roche Sur Yon Cedex 9, France, 85925
|Research Site
|Marseille, France, 13009
|Research Site
|Nantes Cedex 2, France, 44202
|Research Site
|Pierre Bénite Cedex, France, 69495
|Research Site
|Toulouse, France, 31052
Sponsors and Collaborators
|Study Director:
More Information
Additional Information:
Keywords provided by Amgen:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT00807859 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 11, 2008
|Last Updated:
|October 30, 2015
Keywords provided by Amgen:
metastatic breast cancer
locally recurrent breast cancer
anti-angiogenic therapy
Additional relevant MeSH terms:
Breast Neoplasms
Neoplasm Metastasis
Neoplasms by Site
Breast Diseases
Skin Diseases
Neoplastic Processes
Pathologic Processes
Albumin-Bound Paclitaxel
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Antimetabolites, Antineoplastic
Protein Kinase Inhibitors
Enzyme Inhibitors
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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Mike Epps Tickets
Ticket Liquidator has tons of Mike Epps stand up tickets for fans looking to see this up-and-comer on the comedy scene. You've seen him on TV, the movies, even heard him on the radio, but now you can watch Mike Epps tour dates live in front of you. In the biz for years, he's got the comedy chops to hang with anyone. You might have seen Mike Epps' stand-up special, Under Rated & Never Faded or from hosting the BET Hip Hop Awards in 2010. Get Mike Epps tickets right here at Ticket Liquidator!
Born Michael Elliot Epps on November 18, 1970, his early years were spent in Indianapolis. He started doing comedy at an early age and as he grew older Epps eventually moved to Atlanta to perform, working at the Comedy Act Theater before moving to New York City and become a part of Def Comedy Jam on HBO. It wasn't long before Mike Epps tickets were the hot item for New York comedy fans. He made it big on comedy, and did some acting along the way too.
Additionally, Mike Epps has shown his musical prowess in various forms. He's performed as Rick James in A Bay Bay by Hurricane Chris and made a song with Pooh Bear called Trying to Be a Gangster. So when he's not selling Mike Epps tickets for comedy shows, you know he's keeping busy. But perhaps his most impressive appearance was on Eminem and Royce Da 5'9" as Bad Meets Evil on the Hell: The Sequel EP. Most recently he starred in Welcome Home Roscoe Jenkins with Martin Laurence as well as James Earl Jones and Joy Bryant. He has appeared in Strays with Vin Diesel, Hancock, Resident Evil, All About the Benjamins, Next Fridays, Malibu's Most Wanted, The Hangover and many more. So if you want to see Mike "Hollywood" Epps in person buy some tickets and you will see the star live.


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Mail: Southern statues symbolize suppession
Mail: Thanks for helping Aiden
More opinion
Fall: Good time to spray musk thistle in rosette stage
Robertson and Delsing re-elected chair, vice chair of NWB
More Ag News
From one of the all-time best Cornhuskers Rex Burkhead being introduced to a roaring crowd to the legendary Tom Osborne leading the Cornhuskers onto the field one last time, it was a Senior Day to remember Saturday, as Nebraska pounded Minnesota 38-14 at Memorial Stadium.
An increasingly confident Taylor Martinez took center stage, completing 21 of 29 passes for 308 yards and two touchdowns with no interceptions.
It added up to the fifth consecutive win for the Huskers (9-2, 6-1 Big Ten), their longest winning streak since Martinez started his career with five consecutive wins as a redshirt freshman.
Here are my top three observations on the Huskers' big win:
1. The NU defensive line has noticeably improved against the run. Moving Cameron Meredith from end to tackle is one of the best moves of the season and Baker Steinkuhler has had a solid senior season. Hawkeye-turned-Cornhusker defensive line coach Rick Kaczenski will return to Iowa City with a solid Husker d-line.
2. Kenny Bell, the talented sophomore from Boulder, Colo., wrapped up a first-team All Big Ten selection at wide receiver with seven catches, including two for touchdowns. Daimion Stafford helped his chances as an all-conference safety by getting an interception. Running back Ameer Abdullah, who passed the 1,000-yard mark against Minnesota, is a darkhorse candidate for all-conference honors, and he's becoming a more intelligent runner each week. Abdullah is looking a little more like his mentor, Burkhead, as he makes mid-run adjustments to find creases in the defense.
3. The punt return game is still a big weakness for Nebraska, but I think it will improve, just as the rest of the team has. I like the decision to put Jamal Turner back to field punts, giving Abdullah more rest. Hopefully, Turner will gain confidence in the kick return game to the same degree he has done it catching passes in pressure situations.
Tad Stryker is the former sports editor of the North Platte Bulletin and provides analysis after each Husker football game for Bulletin readers. Stryker also writes for HuskerMax. (http://www.huskermax.com).
Flatrock Publishing, Inc.
1300 E 4th St., Suite F
North Platte, NE 69101


text:
A portion of the Heat's schedule is out.
Miami opens the season Oct. 26 at the Boston Celtics (not pictured).
The other games we know about are Orlando for the home opener and, of course, the Lakers on Christmas in LA.
Doesn't Matter
Here's the thing about the Heat schedule.
It doesn't really matter who they play.
All 82 games, the Heat are the show.
I remember in the early stages of the franchise, when you'd look forward to Michael Jordan or Karl Malone coming to town.
The Heat were bad and you waited for the opposition to make the game interesting.
If there wasn't a worthy opponent, there would be plenty of empty seats at the old Miami Arena.
Bring It On
My how that has changed -- 41 road games this year, 41 sellouts.
Print it.
The Heat are the biggest story in the NBA and likely all of sports starting on Oct. 26.
So bring on whoever you want, in whatever order you want.
Wade, LeBron and Bosh will be ready.
Copyright 2011 by Post-Newsweek Stations. All rights reserved. This material may not be published, broadcast, rewritten or redistributed


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The North Face Endurance Challenge Half Marathon at Bear Mountain, NY. Saturday hosted the 50 mile, 50k and marathon races while Sunday had the marathon relay, half marathon, 10k and 5k.
It's a big, scary name - and rightly so, since they warned us repeatedly of the course's extreme rockiness and hilliness (over 2,000ft elevation change for the half).
All the same, I couldn't help but feel slightly lame going to pick up my bib and tshirt the day before and watching the 50 milers alternately power or struggle through the last few aid stations. We rode a shuttle with them back down to the parking lot and wow.... I mean, I've seen pictures of these elite-looking ultrarunners, but being near them in person is totally different. They look like a separate species. Every little muscle is rippling right under the surface of their skin and tattoos abound. One long-haired and bearded guy who had just finished his 50 miles took off barefoot across the parking lot after stepping off the bus. To his car? To run home? Who knows!
Anyway. We hung out at the bed & breakfast we had rented rooms at for the night before which was absolutely gorgeous. It was sitting up on a high hill right next to the Hudson River with beautiful views and a relaxing stone patio. The weather was perfect, too: sunny and ~65 with a light breeze. All the runners that weekend got lucky with that.
Some funny things about the B&B owners: we first met the husband and asked him if there was anywhere we could grab lunch, and he went on and on about burger joints and steak sandwiches. We asked if there was anywhere that had something lighter, and he gave us this confused glance and said, "well, there's a pizza place down the road...?" Haha. We just figured it out ourselves and managed to find a pub with an eggplant sandwich. Later on in the evening, he asked when we'd like breakfast - a sausage quiche his wife had made. We said we'd have to eat something pretty light by 7am and he got this horrified look on his face and then said, okay so you'll then be back and can have the quiche at 10? Errr... no, probably more like noon. I don't think anything that we said made any sense to him whatsoever so he just kind of backed away and said goodnight.
His wife was a little more conscious of what quirkiness might be entailed in running a race, however, and was up and toasting us english muffins at 6:30am. She made us coffee, cut up fresh fruit and searched around for peanut butter. She said her husband told her we wanted to eat at 8:30 ("...but that didn't sound right") and that we'd want something light when we got back from the race ("...and that didn't sound right either.") Thank goodness for that woman. She kept us fueled before and after!
All ready!!
We got dropped off at the start and it was pretty incredible. Clear blue sky, warm sun, cool air, lots of excited people milling around this massive green field and all the leaves just budding.
We checked our bag and started to warm up. The people doing the half were much more normal-looking than the ultra people the day before, which just means they were pretty in shape and sporting aggressive Camelbaks and one guy even had a GoPro camera strapped to his chest. You know. Normal.
Me eating the first Gu and trying to get it to squish through my teeth for the picture.
Dean Karnazes was on the microphone and sent us off in waves because there were too many people for everyone to start at once. It seemed like almost everybody stuck back in the 4th wave. Standing in the crowd I was more nervous than I'd been in a long time. Despite having scoped the trails out a few weeks back and putting in lots of hill work, I still worried that I had no idea what was in store. Dean shouted the fourth and final wave on and we all gave a ragged cheer going under the arch.
It was across the grassy field and into the woods where people immediately bottlenecked onto the doubletrack and leave covered fist-sized gravel. Whenever I could walk and still keep up with the person ahead of me, I did. It was off and on walking and running for the first mile and a half until people sorted themselves out. It probably helped that it was doubletrack for much of the first two miles and the passers could safely swing by on the left.
Jen and I had some kind of runner-friend telepathy going on. We were going to stick together since this was the first trail race for both of us and we wanted to make 100% sure we had someone else in case the intense terrain proved too much. We traded leads back and forth and we passed and got passed.
As lots of distance runners know, you don't really start feeling good until about 3-4 miles in. There were quite a few hills in the first three miles and that stretch ended with a run across a big flat parking lot, which shockingly was way worse than the trails. It's already happening!! The trails demanded so much attention to detail that the parking lot got really boring really fast. When we went back into the trees it was a relief.
The next big hill halted the line of runners in their tracks. Hands were involved climbing the rocks.
It was on the other side, going down, that I felt was the only time I got a little annoyed with being stuck behind people. One girl was picking her way down painfully slowly. Don't get me wrong - it was VERY steep with lots of jagged and loose rocks, but she didn't stand by to let the 20+ people directly behind her go. I felt it was more dangerous to have everyone on top of each other than let it thin out and take the time you need.
Understandably, some people in the back got fed up and started whipping down the sides, sliding around in the leaf cover and knocking some rocks loose. It was even more dangerous and I just tried to get away from the clogged trail and the fast downhillers. We evened out at the bottom and continued on.
Jen and I were feeling good by about halfway. We had only seen one casualty: a man was standing by the side of the trail, face absolutely covered in blood, as a volunteer dumped a gallon of water on his head, saying "I just want to finish!" We found out later he had run facefirst into a low-hanging branch.
Neither of us had remembered to turn off the auto-pause on our Garmins so we quickly lost track of the distance as they paused when we power hiked up the hills. It was okay since we didn't really have time to worry about much more than not falling and breaking our legs on the neverending river of stones under our feet. We flew through the 8.3 mile aid station - where they had a timing mat in the middle of the woods?? Unexpected and pretty awesome of the volunteers to drag it all that way out there.
After what felt like a quarter mile on a trail that was pitched about 30deg down to our right and a few more steep hills (there are no switchbacks at Bear, the trails just charge straight up the incline), we encountered the Mother Hill. Hiking was difficult. It didn't want to end. Nobody really talked and the woods echoed with the sounds of lungs gasping for air. People definitely stopped to rest at the top, but we knew from looking at the elevation chart that we were past mile 10 and everything else was mostly downhill from there.
The top of the Mother Hill.
We started flying as the trail opened up and had a gentle grade down. This is where we encountered Mike and Dave, the former being extremely friendly and a little too open about giving running advice and the latter pretty chill and just wanting to run. I'm fairly sure the desire to finish the last couple of miles without incessant advice about post-race refueling got Jen and I a second wind. We pulled away from them and made it out of the woods.
After a solid two and a half hours of running with almost no spectators, I was surprised to see a bunch of people lining the last hundred yards to the finish. It was very different from a road race. They made eye contact, clapped and solemnly said "good job!" instead of crazy screaming and sign-waving.
It was interesting. I have to think more about what that might mean about trail running and trail runners in general.
They announced our names and got Jen's wrong as we did a combined flying leap over the mat. We got our medals and reusable water bottles (one of the best ideas ever, seriously) and managed a shaky, not-quite coordinated high five. We took pictures of our dirty feet. We tried to stretch and used the ports and ate some hot dogs. Then we laid in the sun until her DBF came and picked us up.
The B&B let us shower and fed us sausage quiche and coffee cake way later than the check out, which was extremely nice of them. We caught up with the other runner staying at the house and shared race stories: Did you see that bloody face guy?! Wow, that hill... I mean, there were a lot of hills-- no, I know which one you're talking about.
Our official time was 2:44:46. 380/666 overall, 69/205 female and 25th of 77 female 26-35.
We both agreed that it had hands-down been the most fun we'd had in a race ever. It didn't seem like 13 miles; it seemed way shorter. It was difficult but rewarding and engaging in a way that none of the road races we've done, both together and separately, had been. The atmosphere and the people were at the same time more welcoming, more chill and more intense than lots of other crowds.
I really loved it.
Ragnar Trail Relay next, then Vermont 50k in September??
The bug has bitten.


text:
The Federal Government will Become America's Model Employer for the 21st Century.
Recruit, Retain and Honor a World-Class Workforce to Serve the American People.
Find out more about Federal compensation throughout your career and around the world.
Staffing to align with your agency's mission
Review the Federal Employees Group Life Insurance (FEGLI) Handbook
Answering your questions about Healthcare and Insurance
Manage your retirement online.
"...The Director of the Office of Personnel Management shall serve as the Suitability and Credentialing Agent..." ~Executive Order 13467, as amended
"...primary executive branch service provider for background investigations..." ~Executive Order 13467, as amended
OPM's Human Resources Solutions organization can help your agency answer this critically important question.
Developing senior leaders in the U.S. Government through Leadership for a Democratic Society, Custom Programs and Interagency Courses.
Visit this federal site to search for our regulatory notices, proposed and final rules.
See the latest tweets on our Twitter feed, like our Facebook pages, watch our YouTube videos, and page through our Flickr photos.
The content available is no longer being updated and as a result you may encounter hyperlinks which no longer function. You should also bear in mind that this content may contain text and references which are no longer applicable as a result of changes in law, regulation and/or administration.
Washington, D.C. -- The U.S. Office of Personnel Management today announced seven targeted goals from the agency's Strategic and Operational Plan were met during the month of August. Each goal was achieved ahead of schedule, with several focused on improving the Federal Government's competitive standing in the marketplace for professional and executive-level employees.
"The summer season for OPM employees has been full of accomplishments," said OPM Director Linda M. Springer. "We moved forward on initiatives that will have a positive impact on job seekers in the career and senior executive ranks, unveiled the new OPM website that has been redesigned for content and ease-of-use, and worked with the Chief Human Capital Officers Council on more-strategic use of job fairs."
The goals achieved in August are:
OPM also continues to air television ads to promote federal job opportunities for college graduates and other experienced professionals across the country.
Our mission is to Recruit, Retain and Honor a World-Class Workforce to Serve the American People. OPM supports U.S. agencies with personnel services and policy leadership including staffing tools, guidance on labor-management relations and programs to improve work force performance.


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New Woodstock Restaurant, Welcome Melaza Caribbean Bistro!
Feels like forever since I have had a chance to write anything on our blog, we've been crazy busy with the fall foliage season. Alas, leaf peeping is about finished, so David and I seized the opportunity last night to try out Woodstock's newest restaurant, Melaza Caribbean Bistro. Melaza, a Puerto Rican, Cuban & Dominican Fusion restaurant, is just down the street from The Village Inn of Woodstock, right in the Village of Woodstock, Vermont.
We were greeted so warmly by James Van Kirk, one of the owners of the Woodstock restaurant. He has this wonderful energy and a great smile. The place is so full of energy, you can't help but love it from the second that you walk in. It was great to see how busy they were, especially since it was a Wednesday in a pretty quiet time here in Woodstock.
We chose to sit in the bar, which like the restaurant, is decorated in warm tones evocative of the Caribbean.
The wine list features nice wines starting at about $20.00 a bottle, a bit of a rarity these days. Hard to go wrong with a bottle of Lunetta Prosecco for $21.00. It was the perfect accompaniment for the Caribbean Tapas Sampler, pictured to the left. Sorry, the pictures in the post are not the greatest - camera battery was really low and I was trying to squeak out a few pictures, no room for do-overs.
James said that we should both order the sampler, that it is one of the best small plates on the menu. Neither of us was disappointed, we both enjoyed the different flavors and textures, and were frankly glad that we didn't have to share.
For entrees, David had the Beef Short Rib, braised in a flavorful tomato cuban creole
sauce, served with garlic mashed potatoes and braised veggies. This was melt in your mouth great, tons of flavor, seasoned just perfectly.
I ordered the Scallops "Veiras" and was equally happy with my selection. Pan seared scallops, served over risotto, with a curry coconut lime sauce, pineapple chutney, and
tamarind glaze. This is where my camera work is awful, but the presentation of the dish was so beautiful that I can't help but share the photo. The portion was beautiful, not a whole ton of risotto, scallops really were the star, along with the wonderfully tangy sauce.
All entrees are served with a green salad with a refreshing house vinaigrette. I called today to ask what the flavoring is, James said that it is Pomegranate. Nice touch, I must say.
We are thrilled to have such an exciting restaurant join our already wonderful dining scene here in Woodstock, VT. We look forward to returning, and highly recommend that you give Melaza a try on your next visit to our Vermont bed and breakfast!


text: You can't sugarcoat Georgia State's ineptness By Dave Hickman September 11, 2013 Story Share MORGANTOWN, W.Va. - Things are pretty bad these days in the Georgia State football program.That's the team that comes to Morgantown Saturday to face West Virginia. It might be one of the worst FBS-level college football teams of all time. It is almost certainly the worst playing right now.Consider that the Panthers, who have been playing the game just three years prior to this one, opened their first year of FBS competition by losing to two FCS programs the last two weeks. And we're not talking upsets like the others sprinkled across the country. Georgia State was the underdog in both and lost badly.Tennessee-Chattanooga beat the Panthers 42-14, rushed for over 400 yards and held Georgia State to 30 yards on the ground. Ouch.This is just a bad football team. Even Dana Holgorsen admits that."So, not to make light of them or anything, but is it hard to find anything good to say about Georgia State?'' I asked the West Virginia coach the other day."Yep,'' Holgorsen said.OK, so he then went into a couple of minutes about how young the program was and that he didn't know much about the facilities and yadda, yadda, yadda. But you get the idea. The Panthers play Alabama in three weeks. Maybe Nick Saban will find something nice to say. And who knows, maybe by then even Trent Miles will be a little more optimistic. He's Georgia State's first-year head coach. But even he's struggling now.After the lopsided loss to Chattanooga - the Mocs led 42-0 at one point - Miles openly questioned his team's effort. It's one thing to be bad. It's quite another to not even try."I don't think we played hard enough,'' Miles said a few days after that game. "I think our expectations were to play harder than we did and I don't feel like our kids played as hard as they possibly could. I thought they got down when UT-Chattanooga took the lead on us. I think they got a little demoralized and hung their heads and it affected how they performed."When young men don't look like they're playing as hard as they can, it makes you look bad talent-wise. That's what happened.''Truth is, the Panthers are probably bad talent-wise, too, and they may have gotten worse this week. Not only is Georgia State losing games, it's losing players, too. Two fifth-year senior offensive linemen quit the team. Both were starters. Oh, and Miles fired his running backs coach, Tony Tiller. And why not? Mack Brown set the precedent a day earlier with Manny Diaz, right? If giving up 550 rushing yards to BYU is a fireable offense for a defensive coordinator, isn't rushing for 30 yards against Chattanooga cause for canning a running backs coach?Things didn't start out this way for the Georgia State program. When the school decided to begin football back in 2007, it hired Dan Reeves as a consultant. Bill Curry was hired as the first coach. The offensive coordinator now is Jeff Jagodzinski, late of the Boston College head-coaching job. The school plays its home games at the Georgia Dome, has a huge enrollment (over 32,000) and is in the heart of one of the best recruiting areas in the country. Things just haven't worked out yet, though. The Panthers did OK in their first year, going 6-5 against teams like Shorter and Lambuth, whatever those are. The schedule was upgraded a bit the next year and the record fell to 3-8. Last year, playing an FCS schedule in the Colonial Athletic Association, the Panthers were 1-10. Curry then bailed.Maybe this capsulizes things as well as possible. At the start of the 2011 season, Georgia State's returning starting quarterback, Drew Little, was suspended for the first four games for violating rules. One backup, Star Jackson, left the team. The other backup, Kelton Hill, was arrested for burglary.Bo Schlechter wound up as the starter. He moved there from punter.All is not lost for Georgia State, though. Miles was hired because he has a history of turning an awful program around. After coaching stints with Stanford, Oklahoma, Notre Dame, Washington and the Green Bay Packers, among other stops, he coached Indiana State the last five seasons. He was 19-14 there the last three years after starting 0-12 and 1-10 while inheriting a team that had won just one game in the previous three seasons.First things first, though. Before Miles can build a winner, he has to build a team that will simply compete. That the Panthers just seemed to give up against Chattanooga was not a good sign. That they play West Virginia and Alabama in two of the next three games doesn't bode well, either.But Miles swears the team that comes to Morgantown Saturday will compete. "After the first game, I thought we were past stage one in teaching them to compete, but obviously I was wrong,'' Miles said. "So we're back to stage one, teaching guys how to compete every play, every down, even when things don't go their way."Even if it's only 11 guys, we're going to put 11 guys on that plane and we're going to go there and play as hard as we can possibly play.''Reach Dave Hickman at 304-348-1734 or email@example.com or follow him at Twitter.com/dphickman1. Story Share Story Share Trending Now 1 Facebook founder visits Cabin Creek Health Systems 2 Safety shutoff disabled prior to June coal-mining death, report says 3 Huggins, WVU tap South Florida hoops talent 4 Teen pleads guilty to voluntary manslaughter in Oakes Field shooting 5 WVU hopes to get injured defenders back for TCU Once around the block Previous Story Point guard commits to Mountaineers Next Story


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Did jealousy lead to road rage?
EUGENE, Ore. -- Did jealousy lead to road rage?
A Eugene woman now says her husband tried to kill her, too, in an incident police call intentional hit-and-run.
Court documents detail what allegedly happened the night of March 14, 2012, when Eugene Police say Francisco Ochoa tried to murder two people and killed a dog by driving his truck up on the sidewalk.
Ochoa's wife told police she was working out with her friend at Gold's Gym off Delta Highway before the incident. When they walked out, she told police Ochoa was waiting for her in the parking lot and yelled, "What the {<}expletive{>} are you doing?" and that their marriage was over.
Court documents say Ochoa's wife then got in a car to drive her friend home, and that Ochoa repeatedly called her as she drove.
Eugene Police say Ochoa's wife and her friend arrived at a house on Snelling Drive. Her friend got out, but his wife said Ochoa yelled at her through the phone, according to court documents.
"Watch me. I'm going to jail," she told police he said.
Police say Ochoa told his wife he was going to run over her friend with a car.
Her friend then walked out of his house with his dog. Ochoa's wife waved at him to warn him of Ochoa's threats, but it was too late.
That's when Ochoa's wife told police she saw her husband speed westbound down Snelling towards her friend, hit him and his dog, leaving these tire marks behind.
Her friend suffered non-life threatening injuries. The dog died. Ochoa ran off, police said.
Ochoa's wife told police she was almost hit, too. A week later, she filed a restraining order against him.
Francisco Ochoa is being held in the Lane County Jail, charged with two counts of attempted murder, hit and run and animal abuse. Bail has not been set.


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Car shows are different in Tijuana
"You do not have to babysit the people from leaning or touching the cars."
Mike Madriaga 2:30 p.m., Sept. 19
2013 Polar Bear Plunge La Jolla Shores
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January 2, 2013
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This game was classified by the community with the following category scores - Violence=3/3, Sex=3/3, Mature Content=3/3. Experience a sexy and mysterious adventure in the Mystic Forest !
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Masterson pleased with progress but needs more time
DETROIT -- Justin Masterson may not have wanted to go on the disabled list, but the Indians' sinkerballer is willing to accept that it was the right decision for the team. While sidelined, the pitcher has worked diligently on both his delivery and his recovery.
"We've made it beneficial," Masterson said prior to Thursday's workout at Comerica Park. "We've done a great job to make it beneficial. Whether you think you need it or not, make it be in our favor."
During the club's optional practice on Thursday, Masterson threw off the mound in a bullpen session, marking his fourth mound workout since being placed on the 15-day DL with a right knee injury on July 8. Over the All-Star break, Masterson has also played catch to avoid going too long without throwing.
Indians manager Terry Francona noted that the next step for Masterson will be to make a Minor League rehab start for Triple-A Columbus on Sunday, though the team is still determining how many innings the right-hander will go in that outing. What is clear is that Masterson will not be able to return to the big league rotation on Wednesday, when he is first eligible for activation.
Masterson has been pleased with the progress he has made behind the scenes.
"Yeah, I think so," Masterson said. "[I'm] feeling a little bit better. We're putting our body in a better position and not put any more stress on it. Just a touch better in mechanics and a couple other things. Pounding the zone."
On the season, Masterson has gone 4-6 with a 5.51 ERA in 19 starts, during which he has been admittedly bothered off and on by his right knee. Prior to landing on the DL, the big righty posted a 9.50 ERA with nearly as many walks (17) as strikeouts (19) in only 18 innings in his previous five starts combined.
Masterson, who was an American League All-Star last season, knows he needs to be better for his team in the second half.
"When I am doing well," Masterson said, "everyone else is having a good time and playing well. Being one of the leaders on the team, definitely [I want to perform better]. I don't feel like it is added pressure. [I need to] go out and be me and a lot of great things will happen."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. This story was not subject to the approval of Major League Baseball or its clubs.


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Photo Gallery: Designers' Holiday Decorating Tips
Steal ideas from 10 of our favourite designers!
Give in to a kid-friendly tree.
A mix of new and vintage ornaments dress this glowing tree. Its stand fits inside a galvanized wash bucket that the owner outfitted with casters for instant portability.
Find more holiday inspiration in our Festive Christmas Trees photo gallery and our Designers' Holiday Decorating Tips photo gallery.
Opt for a longer lasting wreath.
"I love a simple, oversized magnolia wreath on the front door — it's both classic and contemporary," says Mauran. "It costs more but lasts longer — I leave mine up all winter."
Splurge on ribbons, wrap and more.
Just pick up number stickers at a craft store and affix them to ornaments for an instant DIY hit — then watch faces light up when they see the display.
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Keep all five senses in mind when decorating for a party.
The 9-1/2-foot Christmas tree, decorated simply with chartreuse and gold ornaments, a grapevine-twig garland and about 2,000 white twinkle lights, serves as a festive focal point in the great room. Gifts wrapped in kraft paper and tied with green and gold ribbons are in keeping with homeowner Pauline Esdale's simple, natural holiday theme.
See more of Pauline Esdale's Festive Home in our photo gallery.
And for more seasonal ideas, see our Designers' Holiday Decorating Tips photo gallery.
See more wreaths in our photo gallery, plus learn tips for decorating a door with small wreaths and crafting a DIY boxwood wreath.
Frame the kids' Santa picture each year to add a personal touch to a console or mantel.
"Even though it's a crazy time of year, we go to Toronto's Yorkdale Mall to have the kids' photo taken with Santa," says Toronto designer Anne Hepfer. "The nostalgia of a child believing in Santa brings tears to my eyes. We stand in line and they ask all kinds of questions about Santa. The only reason I'm in this photo is because they wouldn't have their photo taken without me in it! I then frame the photo and display it in the living room for the holiday season."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Send simple, classic greetings in lieu of digital prints.
"Every year we send out a family holiday card," says Toronto designer Hepfer. "Call me a traditionalist, but I still like to glue the photo on. The quality is just better than the new digital formats. I order my cards from The Printery in Oyster Bay, New York."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Trade poinsettias for paperwhites.
Layering antique furniture with soft shades of lilac, this room is an elegant and upscale take on holiday dining. There's no ornamentation here; a garland of magnolia leaves decorating the 19th-century Dominican sideboard, potted paperwhites and a single vase of hydrangeas, lilies and berries offers subtle nods to the season.
Find more inspiration in our photo galleries of Thanksgiving Tables and Holiday Tables, plus see more holiday decorating ideas in our photo galleries of Christmas Decorating and Designers' Holiday Decorating Tips.
No mantel? Display Christmas cards on a large board instead.
Toronto designer Anne Hepfer keeps hers up all year for the kids to enjoy: "All of the holiday cards we receive go up on a giant bulletin board in our playroom and they stay up all year long. The kids love looking at photos of their friends and relatives — a lot of whom are in the U.S. and abroad."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Secure sentimental ornaments to the tree with wire.
"We decorate the tree together as a family with the ornaments that we've collected over the years," says Toronto designer Anne Hepfer. "Each ornament has a special meaning or memory. My most sentimental ornament is a Christopher Radko "Brave Heart" which commemorates September 11, 2001. I was living in New York City on that tragic day. I wire on any breakable ornaments to the tree, that way if a child, pet or person accidentally bumps the tree, we don't have any casualties!"
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Logs add a rustic, wintery feel.
This charming chimney is framed by rough beams, while the windows are flanked by sweet interior shutters. Fireplace tools hang neatly from a set of antlers, turning these utilitarian objects into rustic objet d'arts.
See more of this country home in our Rustic Fall Farmhouse photo gallery, plus find more inspiration in our photo galleries of Cosy Winter Cabins and Designers' Holiday Decorating Tips.
Invest in fresh flowers for a party.
Toronto designer Philip Mitchell doesn't cheap out on faux flowers for the holidays — he can't resist the fresh scents of pine and fresh flowers. "My partner Mark and I generally entertain a great deal and there's something wonderful about fresh greens/flowers throughout our home and office," he says. "Though it's more expensive and a little more work to maintain the scent and texture of fresh pine, flowers and magnolia leaves, they definitely complete our holiday decorating. We lean towards mostly green and red flowers (like these amaryllis) during the holidays — being traditionalists at heart."
For more on amaryllis holiday flowers, watch this video. Plus, see our Designers' Holiday Decorating Tips photo gallery.
Group holiday collectibles for impact.
"We display nutcrackers that Mark started collecting a number of years ago — gifts from friends and family and others we have purchased on trips abroad," says Toronto designer Philip Mitchell. "It's always nice to be able to enjoy this display and the sentiment attached to it during the holidays."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Adorn exterior windows.
"We like to add fresh wreaths to all of our exterior windows," says Mitchell. "It has an enormous impact on passersby, as well as any holiday guests we have."
Plant holly in your garden for fresh greenery come Christmas.
Toronto designer Philip Mitchell keeps it local by growing his own festive greenery: "We have always planted an abundance of holly bushes in our gardens so that we have plenty to cut from when the holiday season rolls around as well as having some lovely red accents with those berries in our garden," he says.
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Stock up your woodpile this season.
"There is almost always a wood burning fire going in our house throughout the month of December," says Toronto designer Philip Mitchell. "It's so wonderfully inviting and brings such a sense of warmth to our living room for us and our guests. It cuts down on the heating bills as well."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Experiment with staircase decorating.
A stunning green garland, dotted with feathery white birds, is wired to the base of the railing so that the top remains free for use. A marble table topped with presents and a vintage candle holder add another festive note without being overly ornamental.
Find more inspiration in our photo galleries of Christmas Decorations, Designers' Holiday Decorating Tips and Gorgeous Garlands.
Create festive tablescapes.
A French-Canadian chest of drawers is paired with a glamorous beveled mirror in this principal bedroom. Reflection is one of designer Colleen McGill's favourite tricks for adding elegance and expanding a Victorian house's skinny proportions.
See more photos in our Christmas decorations gallery. Enjoy more shots of McGill's space, also, or view her entire house in our November 2008 issue.
For more ideas, see our Designers' Holiday Decorating Tips gallery, our Holiday Wreaths gallery, plus learn tips for decorating a door with small wreaths and crafting a DIY boxwood wreath.
Impress neighbours with log reindeer.
"When we bought and renovated our house on Vancouver's Trinity Street in the summer/fall of 2003, we had no idea about Trinity's reputation for amazing Christmas lights and displays," says designer Shelley Penner. "It only dawned on me when I was putting up our lights outside the first year. I noticed one of the strings of lights I had was no longer working, and within minutes, our neighbour across the street (a.k.a. the Trinity Street Christmas lights organizer) kindly offered a string she was not using to ensure our display was balanced. For the first few years I took on the task of tastefully decorating the outside of our house. I believe it was the second year that I purchased three very cute reindeer made out of tree limbs and branches. Our next-door neighbour, who is always building something, took it upon himself to help the reindeer multiply. So we ended up with about 20 reindeer between our front yards. We then came up with the "deer in the headlights" concept, which this photo doesn't illustrate well. It snowed in Vancouver that year and didn't melt right away. So at night we would turn on what looked like headlights on the deer and they would cast the most wonderful shadows."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Look to fashion trends for gift wrapping.
Toronto designers Christine Ralphs and Michelle Lloyd of Lloyd Ralphs Design swap the usual red and green for unexpected colour and pattern combinations: "The holidays are a great time to indulge in personal projects, and gift wrapping is the perfect outlet for creative expression!" Ralphs says. "I'm always inspired by fashion, so incorporating the season's trends in my gift wrapping is my favourite theme. This year, leopard is key. Leopard paper with black ribbon is classic, but for the real news of the season, pair leopard-print wrapping paper with Hermès orange and hot pink ribbon, or leopard-print paper with Yves Klein blue and kelly green. Python print is another hot trend, whether it's a neutral python print with flesh-coloured ribbon or a python print in red or kelly green. Look no further than the runways for holiday inspiration!"
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Don't be too matchy-matchy.
Instead of going for an overly coordinated tree, mix and match new and vintage decorations in a variety of shapes, sizes and saturated hues to achieve a playful feel — the more colour, the merrier! Use a graphic patterned giftwrap — here, it's stripes and polka dots — to amp up the drama of the tree.
Find more inspiration in our photo galleries of Christmas Decorations, 3 Holiday Decorating Styles, Bold Holiday Colour Combinations and Designers' Holiday Decorating Tips.
Bring the outdoors in.
"This year my focus is going to be on natural elements — cedar boughs, berries, pine cones, pomegranates; anything in nature. They smell and look great!" says Reid.
Embrace mix-and-match dining when hosting large groups.
It's Christmas tradition in many families to cram dozens of people into a space that normally seats four. This year, embrace the chaos and set a charming, mix-and-match table. Toronto designer Sarah Richardson remembers a year the dining table featured a mix of silver cutlery from her mother-in-law, antique Limogoes plates from her own mother, dinner plates from her grandmother, and placemats made from an Irish linen runner. "I think what's important is not getting too caught up in having a perfectly matched setting for 12 people," says Richardson. "I can't imagine anything looking tickety-boo because then it has no reflection of history."
For more ideas, see our Designers' Holiday Decorating Tips photo gallery.
Spruce up an entryway with urns.
This classic house already has all the elements of a welcoming entry: wide flagstone stairs, a gorgeous arched doorway and pair of glowing lanterns. But it's the matching evergreen-filled planters and simple boxwood wreath — with their lush green tones — that make this red brick exterior really sing.
For more ideas, see our Designers' Holiday Decorating Tips photo gallery. Plus, see more wreaths in our photo gallery, and learn tips for decorating a door with small wreaths. Or browse through more festive exterior decorating photos in our Outdoor Holiday Decorations gallery.
Secure a tall tree to walls with fishing line.
All-white decorations give this pre-lit tree a dreamy quality, bringing a snowy winter wonderland indoors. White-wrapped presents are trimmed with metallic gold and silver ribbon for sparkle. A gilt-framed mirror, candelabra and the glossy dark floor exude luxury and refinement.
See more holiday decorating ideas in our Christmas Decorating gallery and our Designers' Holiday Decorating Tips gallery.
Set aside small hostess gifts for last-minute parties.
Shimmery golds mix with organic browns in the Woodland Splendour collection. Varying ornament sizes and shapes give the tree sophistication, while the large bow atop completes the look. Use striped gift wrapping paper with solid ribbons, and pair kraft paper with any ribbon suiting your colour scheme.
See more of Debbie Travis's holiday décor in our photo gallery. Find everything you need to get the Woodland Splendour look at Canadian Tire.


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There is no shortage of positive story lines among the four local teams competing in community college bowl games Saturday.
Diablo Valley (6-4) will host Laney (5-5) in the inaugural East Bay Bowl, the teams' first meeting since 2005. Kickoff is 1 p.m. in Pleasant Hill.
Chabot (6-4), which has earned back-to-back Golden Gate Conference titles for the first time since 1981, heads north to face College of the Siskiyous (9-1) in the NCFA Central Division Bowl at noon in Weed.
Emerging Contra Costa (7-3), the Bay Valley Conference champion, faces Monterey Peninsula (5-5) in the Living Breath Foundation Bowl at 1 p.m. in Monterey.
The Comets have 17 wins overall in coach Alonzo Carter's first three seasons, after they had just three victories in the previous three years combined.
"My biggest goal was to change the mentality of the team: Play smash-mouth offense and good defense," Carter said. "That's old-school Bill Parcells, Jimmy Johnson, that type of stuff. That's our philosophy. Our team doesn't score a bunch of points. We want the game to be ugly."
DVC coach Mike Darr wants the East Bay Bowl to be a beautiful thing for everyone involved.
"What could be better than hosting in the postseason?" Darr said. "It's a great situation to have these schools that are 20-some miles apart finally play each other again. These kids were in middle school the last time these two schools met."
Darr characterized the Vikings' season as bittersweet.
"It's been a real special group that has played incredibly well," he said. "We are literally four plays from being undefeated against some very good teams."
DVC quarterback Quinn Kaehler, the Mid-Empire Conference Offensive MVP, ranks second in the state in yards passing per game (370.4) and touchdowns (36). Three Vikings wideouts made first-team all conference — Diante Jackson, Andre Lewis and Cameron Rowlan — among 12 DVC selections. Kyle Kragen is seventh in the state with 11.5 sacks.
Laney, the GGC co-champs with Chabot, boasts defensive back Jamal Mayo, among 10 all-conference picks. When the teams last met, Laney beat DVC 35-24 on October 2005 in the GGC.
Contra Costa clinched the BVC title with a 33-14 win over rival Los Medanos on Nov. 10. Rashad Hall leads the Comets with 1,300 yards rushing. Linebacker Eriquel Florence, the BVC Defensive Player of the Year, led a stout defense with six total sacks and 8.7 tackles a game.
Chabot coach Danny Calcagno, the GGC Coach of the Year, is thrilled to advance this far after starting the season 0-4.
"I thought the kids did a pretty good job of showing resolve and staying with it and rallying up," Calcagno said.
Calcagno gives high marks to his offensive coaches Nick Goulet and Neal Fromson. Quarterback Brandyn Eckhart emerged from a slow start to complete 70 percent of his passes over the final three games. Casey Jennings had 48 receptions. Hunter Rockwell (727 yards) and Asante McCrae (553) paced the running game.


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Why No Explosion?Science brain teasers require understanding of the physical or biological world and the laws that govern it.
It is scientific fact that if all else is held constant, the pressure of a gas varies directly with its temperature. In other words, if you have a gas in a sealed, insulated, rigid container and you double its temperature, its pressure will also double. If you triple the temperature, the pressure will triple, etc. This is not EXACTLY true, but it is close enough for the purpose of this teaser.
Why is it, then, that if I were to fill my tires with 32 psi of air on a day that is 2 degrees Celsius, the tires won't explode if the temperature later increases to 20 degrees Celsius (which would seemingly increase the pressure 10-fold to 320 psi, well beyond the capacity of most tires)?
Assume that the temperature of the air in the tire always matches the temperature outdoors: it starts at 2 degrees and ends at 20 degrees.
Also ignore the fact that the tires will expand.
HintThis problem is really more mathematical than scientific. Here's a hint: say you have a temperature of -10 degrees Celsius. Now double that temperature. You get -20 degrees. Doesn't it seem a little odd that when you double something's temperature that it actually goes DOWN?? When you double something's LENGTH, it never goes DOWN. What's wrong here?
AnswerLike the hint implies, the key to this teaser is understanding what you are really doing when you multiply numbers. For example, if you have the number 3 on a number line and you want to double it, what you could do is put your thumb at 0 and your index finger at 3, and then measure off that distance past 3 one time, which will of course bring you to 6. You are essentially doubling the distance that 3 is from 0 to get 6. The only reason this works, however, is because at 0 you really have ZERO length. 0 really means "nothing" in this case. With the Celsius temperature scale, however, 0 degrees does not mean that you have "no temperature". 0 degrees was chosen arbitrarily to coincide with the freezing point of water. Other than that, it has no real significance. So if you want to multiply 2 degrees C by 10, you have to increase its distance from ABSOLUTE zero by 10, not its distance from the arbitrary 0.
Absolute zero is about -273 degrees C. At this point, there really is "no temperature". So when the temperature in the problem goes from 2 degrees to 20 degrees, it is really going a "distance" of 275 degrees from zero to a distance of 293 degrees from zero, which is only an increase of 6.5 percent, not enough to make your tires explode.
The moral of this story is that if you want to multiply numbers, the numbers themselves must represent their "distance" from a true zero. You can add and subtract numbers without knowing this "distance", but you can't multiply and divide.
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