text:
found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already spayed, up to date with shots, good with kids, good with dogs, and good with cats.
The adoption fee for this kitten is 130.00 which includes Spay/neuter and age appropriate vaccinations.
Weekends -
This cat will be available at our site adjoining Sayrebrook Veterinary Hospital at 1400 Main St (actual GPS address 989 main), Sayreville NJ 08872. This is at the T intersection of No. Ernston Rd and Main St.
Open Sat and Sun, 11 to 4:00. Directions are on our site.
Weekdays -
This cat is in a foster home and is available to meet during the week per request.
For more info or an application, please email Amy at firstname.lastname@example.com
Angel, a East Brunswick Domestic Shorthair cat was adopted! Here's how you can benefit by looking at adoption as an option to buying a Domestic Shorthair for sale in East Brunswick, or seeking a Domestic Shorthair cat from a breeder in East Brunswick.


text:
J.C. Penney is making headlines again thanks to shareholder Alan Marcus, who is suing the troubled department store chain because of its recent decision to build equity by issuing more than $800 million worth of new stock, which sent share values plunging, Reuters reported.
The report said Marcus, who bought 300 shares of Penney stock on Sept. 26 shortly before the new stock was announced, is trying to obtain class-action status for his suit.
Marcus is being represented by law firm Robbins Geller Rudman & Dowd, which often represents plaintiffs in class action suits. He wants the suit to cover anyone who held Penney shares between Aug. 20 and Sept. 26, 2013.

subset: commoncrawl


text:
TV's Hottest Cop
As David Caruso savors the global success of "CSI: Miami," the former star of "NYPD Blue" won't forget the lessons he's learned, or the cigars he loves.
(continued from page 9)
Numbers matter in Hollywood but even Tinseltown's most talented screenwriters would have a hard time coming up with a more compelling "phoenix from the ashes" story than that of actor David Caruso. His staggering success on "CSI Miami" eclipses nearly any rebirth-and-success script that Hollywood could possibly produce.
Each week, an estimated 50 million viewers around the world tune in to catch Caruso—as dedicated crime scene investigator Lieutenant Horatio Caine—and the rest of the "CSI: Miami" cast fight terrorists, snatch potential tsunami victims out of harm's way and catch (or kill) drug lords, murderers and kidnappers through their work on the street and in the forensics lab. That the show is so spectacularly successful around the world should come as no surprise; "CSI: Miami" is, after all, the 2002 spin-off of the then-two-year-old, No. 1 drama series on television, "CSI: Crime Scene Investigation."
A spin-off of any show, even one with the incredible ratings of a "Friends" or "Seinfeld," could—and often does—bomb right off the bat with the fickle American audience. But with the original Las Vegas—based "CSI" introducing its Miami-based little brother and cast—especially David Caruso as the male lead—Act 2 in the "CSI" series was orchestrated beautifully, right from the opening credits.
Now in its fifth season and having, in turn, helped spin off yet a third act in the CBS—Jerry Bruckheimer franchise by introducing the cast and story line behind "CSI: New York," the show's success makes perfect sense. But the fact that Caruso, as the red-haired, fair-skinned and infinitely grim Horatio Caine, has become an international star still comes as a bit of a surprise to the 50-year-old actor. A pleasant surprise.
"On a return trip to Los Angeles from Cannes this spring, I was in Heathrow and there were people from all over the world [recognizing] me and talking to me, and suddenly there was this gaggle of about 20 people from Taiwan that came running over. The only word they knew in English," says Caruso, a little sheepishly, "was 'Horatio.'"
Caruso grins and shakes his head as he tells the story. "It wasn't, you know, as if it was the Rolling Stones walking [by] at Heathrow. I mean, it's not like seeing and running up to Mick Jagger…now, he's bigger than life!"
Well, in some respects, so is David Caruso's Horatio Caine. "CSI: Miami" now airs in some 200 countries and is estimated by industry tracking guides to be the most-watched television show on the planet. That 12 years ago David Caruso was having trouble landing acting roles—any role, much less one as the lead in a series with the lineage and capacity for success that "CSI: Miami" offered—isn't lost on him.
For one thing, as Caruso is quick to point out, he doesn't have what he calls "leading man looks. In acting, especially in motion pictures, in my opinion, you have to have a level of physical beauty that is on the superlative level. If you look at the current crop of stars out there, they have a very superior physical presence on camera. Let's face it, you just can't look away from Brad Pitt," Caruso laughs. "Pitt has tremendous physical beauty and presence, much like Paul Newman did. Now, if they're interested in me, they're interested in, you know, a 'street version' because I just don't look like a leading man."
David Caruso is, in fact, an attractive man and one of those rare creatures in Hollywood who is actually more attractive in person than on the screen; he has a softer, more animated face that not only lights up when he smiles and laughs, but also moves when his expression changes, a rarity in Botox-friendly Southern California.
Whether it's Caruso's looks by themselves or his ability to portray a strong, responsible, "nobody-knows-the-trouble-I've-seen" street-weary cop, the actor has an undeniable "it" factor when it comes to popularity with both male and female viewers; for proof, one need look no further than the success he had on the gritty crime drama "NYPD Blue."
Although Caruso had some modest success in the '80s with small roles in movies such as Thief of Hearts, An Officer and a Gentleman and First Blood, it was his skill at playing Detective John Kelly on "NYPD Blue" that first made David Caruso a household name. Well, that and an episode involving his naked butt, which helped set a new standard for nudity on prime-time television.
When it debuted in 1993, "NYPD Blue" had the same kind of impressive pedigree as "CSI: Miami." Created and executive-produced by Steven Bochco, the same man behind the back-to-back hit dramas "L.A. Law" and "Hill Street Blues," "NYPD Blue" featured an ensemble cast of characters whose strengths and weaknesses, foibles and faux pas were recognizable to the average viewer. Even in its first season the show was a runaway hit, and much praise was heaped on the cast, which included Gordon Clapp, a relatively unknown Dennis Franz and, of course, Caruso.
If there were industry rumors that egos were expanding—and clashing—on the "NYPD Blue" set, these tales were muted compared to the hype surrounding the show itself. Caruso was terrific as Kelly and he played the role to the hilt…for just 26 episodes. In 1994, only four episodes into the second season of the top-rated show, Caruso decided to play a little career poker. With a movie offer in hand, he asked for an extraordinary salary increase. The network called his bluff and Caruso walked, telling the press that "'NYPD Blue' will not be successful when I leave."
The movie that Caruso left to make was Kiss of Death, a medium-budget suspense feature that had Caruso playing a good-hearted ex-con opposite Samuel L. Jackson and Nicolas Cage. Perhaps the film's title should have served as an omen to Caruso; released in late 1994 and grossing less than $15 million in the United States, the film didn't live up to anyone's expectations, especially Caruso's. And his next big-screen venture did even worse. In spite of returning Caruso to a role that had him on the right side of the law, the erotic thriller Jade cost nearly $50 million to make and took in less than $10 million in its U.S. release. A year after Caruso had earned an Emmy nomination and a Golden Globe award, for Best Performance by an Actor in a Television Series—Drama, for "NYPD Blue," he found himself nominated for a Razzie Award for Worst New Movie Actor.
With those kinds of box-office numbers and generally scathing reviews of his performances, 1995 was a bittersweet year for the actor, then 38. It was also the beginning of a very quiet decade in David Caruso's career and no one, it seems, takes on the burden of responsibility for that debacle more than David Caruso.
"I wasn't ready for the success," he says, quietly. "Not then."
When reminiscing about his early career and the people he worked and spent time with, Caruso is unflinching both in his admission of "letting others down" in his abrupt departure from "NYPD Blue" and his acknowledgement of the wide berth that Hollywood gave him in the years to follow.
"My experience over the past 30 years [acting] is that Hollywood casts itself and Hollywood will let you know where you belong," Caruso explains, haltingly. "Different people serve different functions. Hollywood will say, you know [pointing as if to an actor lineup], 'features, features, television, television, features, television, theater, features, television.' And," he pauses, "they cast it themselves because there are people they have needs for. They need to fill these slots and these functions, and some people are considered big-screen people and some are television people."
Caruso had always dreamt of being on the big screen, but, he says, Hollywood told him "television." Caruso had done some TV roles prior to "NYPD Blue" and, in fact, had come to interest Steven Bochco as a possibility for the role of John Kelly because of the recurring role he played on Bochco's earlier police-themed hit, "Hill Street Blues."
Caruso insists that he loved the idea of "NYPD Blue" from the moment he was approached to play Detective Kelly, calling the show "one of the greatest [television] hours ever. 'NYPD Blue' had a feature [film] sensibility and a feature quality to it, and when I first looked at a brilliant script by David Milch for the show, it read like a 1930s Jimmy Cagney picture! It was brilliant and it read, it felt, like a feature movie."
Unfortunately for Caruso, although it was a hugely successful role for him, it wasn't the feature movie that he'd always dreamed about. When the offer came for the lead role in Kiss of Death, he says he made a knee-jerk decision.
"I think," Caruso says slowly, "that my inexperience in the area of responsibility and my inexperience with the suddenness of opportunity caught up to me…the sudden opportunity to be on the big screen. It was something that I'd always fantasized about but I guess never taken that seriously because I [hadn't] gotten that signal from Hollywood. Remember, I was 'television,' not 'feature.'"
Suddenly, Caruso says, his popularity and immense exposure on "NYPD Blue" gave him that big-screen opportunity and, he admits, some arrogance. "I was overwhelmed with the suddenness of it…and I didn't have the wherewithal and the experience to make good decisions at the time. I was making decisions from a very green perspective and it got away from me in a way that was painful to a lot of other people. The easy, cheap answer is that if I had the opportunity to redo it I wouldn't have left 'NYPD Blue' because that was my world, my opportunity and, you know, at the end of the day in show business, you just don't," Caruso chuckles, "leave a hit show."
If, as Caruso puts it, the entertainment industry takes it upon itself to cast talent in the style and roles it deems fit, it also reprimands those who step outside of the slot in which they've been assigned. With the rare exception of names such as Clooney, Depp, Travolta and Aniston, very few actors have successfully made the move from television to features, and Caruso, who had ruffled some feathers on his journey, suddenly became Hollywood's very public poster boy for bad decisions and bad behavior.
Late-night comedians and talk show hosts routinely used phrases such as "pulling a Caruso" when referring to someone's career backslide; film critics would use Caruso's career decisions as a measuring stick when looking to diss another television actor's foray into feature films, and even Comedy Central's animated show "South Park" got in a dig when one of the main characters urged his brother to jump from a dangerous height with the words, "Show me your imitation of David Caruso's career!"
Ouch. Being openly dissed in an industry so ready to eat its own might make a lesser man turn, tuck tail and run. What no one counted on was Caruso showing some stamina. And some spine.
Born in Forest Hills, New York, David Caruso was simply born stubborn, an amalgam of an Italian father, an Irish mother and a family that split apart just two years after David's birth. To support David and his older sister, David's mother, Joan, moved with her young family into her parents' home and went back to school to become a librarian.
Caruso describes his early years growing up in Queens as merely average. He was, by his own admission, a mediocre student who didn't get excited about much of anything unless it involved the movies. In fact, there was one particular movie that, he says, goes a long way toward defining the sheer wonder he felt as a child, at spending two hours in a darkened theater.
"It was The Godfather," Caruso says, "and my closest friend, Lou Mathis, and I went to see it on a Friday night. We took the Q60 bus down Queens Boulevard to the Elmwood Theatre to see The Godfather. We were 13 years old and we came back changed. Changed! We stood under the lamppost on Puritan Avenue and I said, 'Lou, I'm going to do that for a living.'"
Caruso shakes his head and smiles at the memory. It was an impractical aim for the boy that he was, coming from a neighborhood where the straight-A students would choose law or medicine, and those with study habits like Caruso's would opt for civil service jobs.
"I was 13 years old and it was an absolutely ludicrous statement to make," says Caruso. "I was not as academically inclined as some people and I don't think I had the discipline at the time. I'm more of a left-brain person. The consumption of repetitive material is something that I'm, uh, not designed for."
That perceived deficit didn't, Caruso admits, keep him from repetitively consuming The Godfather—and the first sequel—many times over. "Which character did I identify with? God, every one of them was so electric that I think that varied. Some days you were Sonny, some days you were Michael and some days," Caruso grins, "you were Fredo."
In spite of his career declaration at 13, Caruso simply waded his way through the rest of school and, although he played a little basketball when he attended Archbishop Molloy High School in Queens, he didn't have a specific game plan for his life or career until, once again, he found himself in a darkened theater, this time, as a movie usher.
While Caruso never doubted his absolute certainty about acting as a career choice, he knew that, for a boy from a middle-class neighborhood in Queens, the chances of achieving that dream were pretty slim.
"There was no reality to that [early] desire because I was just another boy on the F train. But," Caruso pauses, "when I became the usher at the movie theater and began to be more influenced by the films, I think the seed of something kind of regerminated. And the thing about New York," Caruso grins, "is that anybody could make up a résumé and go around and try to get people, fool people, into hiring you."
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text:
rory wrote:we're all bodhisattvas - that's Original Enlightenment thought, which I really reject. We all have buddhanature and the potential to be bodhisattvas but it takes lots of hard work to make it grow and develop. Some people don't try at all. This kind of thing can turn into a 'you're perfect as you are' I try daily to think about my behavior and control it and do good things. It's hard, it's not easy.
Original Enlightenment thought has a long & deep history in Japanese Buddhism. I'd like to know what role it plays in Nichiren's thought and practice. Did Nichiren advocate original enlightenment (hongaku shiso), reject it, avoid talking of it...?


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Bestival Tickets
Since its arrival to the festival scene in 2004, every year Bestival - held in the Isle of Wight in England - has always been one to watch out for on the festival calendar. Organiser Rob da Bank has never failed to bring to the stage musical talent that always satisfies the fans! Over the years hundreds of DJ sets, live music artists and bands have graced the stage and seen Bestival grow in popularity recently drawing crowds over 50,000. Bestival is known for focusing less on mainstream music artists, proactively highlighting alternative talent and providing a festival park that is filled with innovative ideas. Those attending can expect excitement at Bestival with past highlights including fancy dress evenings, an inflatable bouncy castle church and a multitude of music talent, with past headliners include Stevie Wonder, Florence and the Machine and New Order. Select a date to view the range of tickets available. You can also sell your spare Bestival 2017 tickets on NME ticket exchange, and listing tickets is free. All Bestival tickets are covered by the NME ticket exchange Ticket guarantee! Don't wait any longer - buy your Bestival tickets now!
In5daysDate & Time to be Confirmed
|Bestival Bali 2017 - 2 Day GWK Cultural Park Bali, Indonesia
|About to sell out - only few tickets left
Can't find the event you're looking for? Tell us about it!


text:
EDUCATION knows no barriers for teachers at the Great Western Hospital who have tutored as many as 600 young patients unable to attend school on the wards and at home in the last year.
Regardless of their condition, which can vary from a broken arm to cancer, the Hospital and Home Education Service ensures every child keeps up with his or her studies.
This is no easy task, with an unpredictable number of youngsters to teach, but it is one which is becoming increasingly necessary and helps maintain a semblance of normality in pupils' lives.
"We get a huge variety of children," said afternoon teacher Andrea Honey.
"Since September we have had 600 children through the door.
"For lots of reasons they are not able to keep up their school education.
"They may have had an accident and that affects them physically, they may be ill or something has happened in their life that has caused emotional issues.
"It might also be children who are through the worst of what they come in for on the wards.
"We have the classroom here but teachers also teach in the community if children are not well enough to go to mainstream school."
"It is two hours a day but because these are smaller group lessons, they are able to catch up on what they are doing. They have the opportunity to get extra input.
"So many students' education has broken down. They come to us at their worst and it's so lovely to see them being able to engage.
"Sometimes it's about having a new start and building up again so they can feel better.
"I think it goes a long way to put them in the right direction."
Eleven-year-old Nova Hreod pupil Anya, who sufferers from seizures, has been attending the afternoon class regularly, where she has been following her school's curriculum.
"I get seizures and I'm quite tired in the morning and when I can't make it into school I come here," she said.
"I think it has made me more confident and the best part about coming here is the teachers."
The teaching team not only helps pupils at a very difficult and frightening time in their lives, they also encourage children to overcome their fears and, if they feel ready for the challenge, gradually return to mainstream school.
After nearly a year with the team, out-patient Emily, 14, who has been struggling with anxiety, is now preparing to start college in September.
"I have anxiety and going to school at the hospital is a bit more relaxed," said the Year 10 student who will sit her GCSE exams next year.
"I have been here for about a year now, two hours a day, and it's helped with my confidence. Now I am looking forward to going to college.
"It has been easier just being able to learn without being in school full time."
One of her classmates, who asked not to be named, has been attending the programme at GWH since falling pregnant.
"I find it a lot better than mainstream school," said the 15-year-old.
"They don't judge. I have been learning English and maths and I find it easier to work and learn here."


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Hingham, Mass. -- The Talbots unveiled its new store design at the Westfield Garden State Plaza in Paramus, N.J.
The 5,500-sq.-ft. store has an upscale, residential feel, with a layout of five individual rooms for different merchandise stories.
Talbots chief creative officer Michael Smaldone collaborated with Robin Kramer of Kramer Design Group on the space.
According to Talbots, extensive customer research and feedback drove many of the important features of the store's design and merchandise presentation, which include a new color palette, a more luxurious fitting room environment, area rugs, marble nesters, ceramic tiles, étagères, brass-rimmed windows and a brass door.
Key elements of the new design concept are being evaluated for potential rollout to existing stores in support of the company's overall store reimage program.
"We are thrilled to bring our customers an innovative and truly inviting shopping environment at our new design concept store in Westfield Garden State Plaza," said Trudy F. Sullivan, Talbots president and CEO.
Talbots unveils new store design
Hingham, Mass. -- The Talbots unveiled its new store design at the Westfield Garden State Plaza in Paramus, N.J.


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Hi, everyone. I'm Erik and I hail from Tigard, south of Portland in Oregon I'm 27 and work as a captioner for the Deaf and hard-of-hearing. I've been practicing Buddhism for only two or three years.
I'm coming to Theravada after starting in Zen, and a brief stint at a Kagyu center in town. My first introduction to Buddhism was Henepola Gunaratana's "Mindfulness in Plain English" which I read while deeply depressed. I had tried to find relief in Christianity, but was unsuccessful. The directness and practical advice of the Buddha and the authors I've read have made such a difference in my suffering and ability to help others with theirs.
I don't know why I never thought to explore Theravada more fully. I delved into Zen because of its no-nonsense approach, which is great for a self-admitted addict to complex theories and metaphysical speculation. It certainly helped put that into perspective. Several things have lined up to bring me full circle back to the tradition that was my gateway from depression into a surprising love and humor I never knew were there. I'm eager to explore it more.
If anyone can recommend local centers, I'd be so grateful. I'm hoping to attend something with the PDX Friends of the Dhamma.
So after all that, hi


text:
Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2014 by Tatiana Valente, Federal University of São Paulo.
Recruitment status was: Recruiting
Recruitment status was: Recruiting
Federal University of São Paulo
Information provided by (Responsible Party):
Tatiana Valente, Federal University of São Paulo
ClinicalTrials.gov Identifier:
First received: November 30, 2011
Last updated: May 13, 2014
Last verified: May 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The primary objective of this study is to evaluate the action of DPP-IV inhibitors in the prevention of progressive beta cell dysfunction in patients with type 1 diabetes mellitus newly diagnosis ( less than 6 months).
The secondary objectives are:
- To define the immune and inflammatory profile
- To define the secretion of glucagon and GLP-1
- To assess the glycemic variability
|Type 1 Diabetes Insulin Dependent Diabetes Juvenile Onset Diabetes Mellitus Autoimmune Diabetes
|Drug: Vildagliptin
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in Residual β-cell Function and Inflammatory Markers in New-onset Type 1 Diabetes Mellitus.
Resource links provided by NLM:
Genetics Home Reference related topics: type 1 diabetes
MedlinePlus related topics: Diabetes Type 1
Drug Information available for: Insulin Insulin humanU.S. FDA Resources
Further study details as provided by Tatiana Valente, Federal University of São Paulo:
Primary Outcome Measures:
- Beta cell function [ Time Frame: C peptide will be measured by the area under the curve of stimulated C peptide within the first 2 hours every 3 months up to one year ]The primary objective of this study is to evaluate the action of DPP-IV inhibitors in the prevention of progressive beta cell dysfunction in patients with type 1 diabetes mellitus newly diagnosis ( less than 6 months). It will be measured by the area under the curve of stimulated C peptide within the first 2 hours
Secondary Outcome Measures:
- Immune and inflammatory profile [ Time Frame: 0,3,6,9,12th months ]
Inflammatory profile will be measured by some markers such as TNF-alpha, IL-10 and PCR.
Immune profile will be obtained by the expression of FOXP3 in both groups.
- Secretion of Glucagon and GLP-1 [ Time Frame: 0,3,6, 9 and 12months ]It will be obtained by the measure of glucagon and GLP-1 levels
- Glycemic variability [ Time Frame: 0, 6 and 12months ]To evaluate the glycemic variability, it will be installed the continuos glucose monitoring system (CGMS) for seven days during the 0, 6 and 12 months.
|Estimated Enrollment:
|Study Start Date:
|March 2014
|Estimated Study Completion Date:
|March 2017
|Estimated Primary Completion Date:
|March 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
No Intervention: Insulin therapy
Patients will receive the conventional treatment with insulin
Active Comparator: Vildagliptin
Patients will receive vildagliptin besides the conventional treatment with insulin
Drug: Vildagliptin
Vildagliptin ( Galvus 50mg twice day) during one year
Other Names:
Detailed Description:
Clinical and autopsy studies show that up to 30% of patients with type 1 diabetes mellitus show a detectable β-cell function at clinical diabetes. The preservation of this endogenous insulin production, even if it is small, can have a great impact on the evolution of long-term disease through improving glycemic control, reducing chronic diabetes complications and hypoglycemia. Strategies for preventing the loss of beta cell are based on stopping the autoimmune process and also in the preservation and regeneration of beta cells. Currently have been questioned the potential use of GLP-1 for new-onset type 1 diabetes. The justification for this issue is based on the fact that this class of drugs, besides acting on insulin secretion and glucose regulation, may be effective to preserve and expand beta cell mass, which has been shown in animals. Ideal candidates for this treatment are newly diagnosed patients who still have significant viable beta cell mass.
|Ages Eligible for Study:
|18 Years to 35 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Aged 18 to 35 years
- Up to 6 months of clinical diagnosis
- Fasting C-peptide ≥ 0.25 ng / ml
- HbA1C <9.0%
- Positive autoantibodies (anti-GAD, Anti-Insulin and Anti-IA2)
- Without chronic complications
Exclusion Criteria:
- Hepatic, cardiac, pulmonary and hematologic disease
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01559025
Please refer to this study by its ClinicalTrials.gov identifier: NCT01559025
|Contact: Tatiana Valente
|Contact: Sergio Dib
|Federal University of São Paulo
|São Paulo, Brazil, 04022-001
|Contact: Tatiana Valente 55119614616 firstname.lastname@example.com
|Contact: Sergio Dib 551197397776 email@example.com
|Sub-Investigator: Monica Gabbay
Sponsors and Collaborators
Federal University of São Paulo
|Principal Investigator:
|Sérgio Dib
More Information
Keywords provided by Tatiana Valente, Federal University of São Paulo:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Tatiana Valente, Principal Investigator, Federal University of São Paulo
|ClinicalTrials.gov Identifier:
|NCT01559025 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 30, 2011
|Last Updated:
|May 13, 2014
Keywords provided by Tatiana Valente, Federal University of São Paulo:
Type 1 diabetes
Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 1
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Autoimmune Diseases
Immune System Diseases
Insulin, Globin Zinc
Hypoglycemic Agents
Physiological Effects of Drugs
Dipeptidyl-Peptidase IV Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017


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CHINO - The slow pace of physical improvements to Chino High School has prompted parents and students to criticize district administration again.
"It's not about money, it's about getting your priorities straight," said Chino High senior Lucas Taylor during public comment at last week's meeting of the Chino Valley Unified School District board.
The comments from the audience, coming before a report on repairs completed or planned in coming weeks at the school, continued a month-long campaign by parents objecting to the district's slowness in dealing with the problems. The frustration by parents even spilled over into last week's Chino City Council meeting,
District officials explained they have begun a series of improvements on the 60-year-old campus, most of which should be completed by the time students return from spring break on April 8.
Receiving the greatest criticism, however, has been the condition of the campus' metal plumbing system, which cannot be replaced in the short term. The San Bernardino County Department of Health did visit the school 10 days ago to test the water for traces of lead.
"I'm confident we'll pass," said Greg Stachura, in charge of the district's facilities.
District spokeswoman Julie Gobin said in an email that repairs have been completed at Chino High including the school's front gates, chin-up bar pole, boys locker room toilets and showers, baseball field dugout benches, lighting on baseball scoreboard, new stadium scoreboard and some new desks.
The email also detailed removal of calcium buildup on the boys locker room tiles, with additional cleaning in the boys and girls locker rooms.
"Leaking/damaged shower valves have been repaired where possible, however, these fixtures are over 50 years old and repair parts are no longer available, nor are replacement fixtures that will fit, without major demolition and remodeling of the shower stalls," the email reads.
The debate over the poor maintenance at Chino High made its way to last week's Chino council meeting, prompting school board President Sylvia Orozco to defend expenditures at some of the district's newer schools - especially a new $5 million pool at Chino Hills High paid for by the Measure M bond. In the $150 million facilities measure passed in 2002, the pool was listed among the projects to be built by Measure M funds. It was not paid for from the district's general fund.
Orozco made no excuses about the poor facility conditions at Chino High but tried to assure the City Council and the audience that work is in progress to clean up the school.
Over the years the school district has been slammed with financial issues, so much so it was forced to closed down three of its schools and lay off dozens of teachers, the district has said.
"Luckily we were able to bring them back because of Proposition 30 (increase sales tax initiative) and now that we can lift our eyes from maintaining our staff we can put them on maintaining our facilities," Orozco said.
"The school board is attempting to rectify some of the issues, and it's true some of them have been rust issues and some of them are issues that should not have gone this far and we're addressing those. "
One of the reasons why Orozco said she ran for the school board was because of poor facility conditions at her son's school, which was Anna Borba Elementary at the time.
Mayor Dennis Yates said he's been in contact with Superintendent Wayne Joseph about the progress that is being made at the school.
"We are monitoring it, and (board member) James Na is visiting the school site on a weekly basis inspecting it and work in progress," Yates said.
"We'll keep an eye on it too. We are concerned about the young people and the district has their own elected board but we have a vested interest in the children and the education of the children. We're not here to tell the school board what to do, but we can express our concerns about the deplorable conditions. "
Reach Canan via email, call her at 909-987-6397 ext. 425, or find her on Twitter @ChinoValleyNow.


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Astros send 10 players to Minor League camp
KISSIMMEE, Fla. -- The Astros trimmed their Spring Training roster by 10 players on Sunday morning, optioning outfielders Robbie Grossman and Jimmy Paredes, shortstop Jonathan Villar and pitchers Paul Clemens and Dallas Keuchel to Minor League camp.
Meanwhile, outfielder Che-Hsuan Lin, catcher Carlos Perez and pitchers C.J. Fick, Josh Zeid and Sergio Escalona were reassigned to Minor League camp.
The moves leave the Astros with 39 players in camp two weeks shy of the March 31 season opener against the Texas Rangers (that doesn't include pitchers Jose Veras and Xavier Cedeno, who are competing in the World Baseball Classic).
"We open up two weeks from today, and even though it's a long Spring Training, it feels as though it's gone very quickly," Astros general manager Jeff Luhnow said. "We've got a lot of work to do here. We've got to get down to 25. Pitchers are going longer in games, we've got innings to dole out, we want to see our position players go a little deeper and have a few more at-bats as well.
"A lot of these guys we're sending out today have a bright future in our organization and they know they'll be back. They need to go down and get regular work and go to their respective Minor League locations and show us what they can do. We know the 25 we start with are not the 25 we're going to have all year.
"They've done, by and large, a good job and especially when you have a new staff at the big league level, it's a clean slate for everybody. Everybody gets to know each other, and I think it's been very good for a lot of these players to really take advantage of a clean slate to go out and [impress]. When the time comes, our staff is not going to hesitate to want them back up here."
The moves do little to clear up any of the Astros' position battles they had to start the spring (Keuchel was competing for a rotation spot), and Luhnow expects those decisions will go down to the wire.
"We want to give everybody the opportunity to show us what they have and we want to take into account the historical context of what they've been able to do," Luhnow said. "It's still murky in the rotation and still murky in the outfield and infield a little bit, so we're going to continue to evaluate and use those at-bats and innings for next two weeks to help us make key decisions on the 25."
Brian McTaggart is a reporter for MLB.com and writes an MLBlog, Tag's Lines. Follow @brianmctaggart on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.


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text:
Moth wrote:I'm interested to hear what you folks think.
I should have had plain peach and melon without that artificial tripleberry sponge crap.
~ The Psychedelic Experience ~
A manual based on the Tibetan Book of the Dead
By Timothy Leary, Ph.D., Ralph Metzner, Ph.D., & Richard Alpert, Ph.D.
http://www.leary.ru/download/leary/Timo ... 20Dead.pdf
Drug tests, Tibetan Dhamma, government interference...otherwise I dunno yet what's in it.


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Not much has changed for us.
Otherwise, Biyombo goes a little up. Vucevic projected in the lottery.
http://insider.espn.go.com/nba/draft...ckDraft-110615With the June 13 date to withdraw from the NBA draft and the adidas Eurocamp behind us, we are now just a week from when the selections will be made.
The draft remains fluid at this point. Teams are still engaged in the workout process and are beginning to narrow down their lists, but the final draft order is still far from certain.
"Good luck with your mock draft," one GM said to me as he was departing Treviso, Italy. "I'll be interested in seeing who we are taking since I still don't know."
Here's our most informed take, after talking to numerous NBA team sources, about how the draft might play out June 23.
1. Cleveland
(via L.A. Clippers)
Kyrie Irving
Position: PG
Height: 6-foot-4
Weight: 191 pounds
Age: 19
School: Duke
Analysis: There have been a lot of interesting theories floating around the past week about why Cleveland won't be taking Irving No. 1. I still don't buy it. The Cavs have been shopping Baron Davis and Ramon Sessions hard in the past week.
Williams is still in the picture here at No. 1 in part because the Cavs feel they could get a very good point guard (either Brandon Knight or Kemba Walker) at No. 4 ... but sources continue to stress that it's Irving's to lose.
2. Minnesota
Derrick Williams
Position: PF
Height: 6-9
Weight: 249
Age: 20
School: Arizona
Analysis: Still hearing that the Wolves are hoping they can get a great offer for the No. 2 pick. But if they don't they'll just take Williams and work out the rest this summer via trades. If they get Williams, Michael Beasley could be gone by the time next season starts.
3. Utah
(via New Jersey)
Brandon Knight
Position: PG
Height: 6-3
Weight: 177
Age: 19
School: Kentucky
Analysis: Brandon Knight and Kemba Walker are both possibilities at guard. Enes Kanter, Jonas Valanciunas and Jan Vesely will also get a look here. The Jazz have a huge workout on June 15 when Walker and Jimmer Fredette are expected to work out for them.
Knight will come in at some point too, though he still seems to be refusing to work out with Walker or Fredette. While it's still possible the Jazz go big with this pick and select either a player like Kanter, Valanciunas or Vesely -- they're likely to try to select a franchise point guard if either Knight or Walker blows them away. If Fredette wins the battle on the 15th ... that could push the Jazz to go big here and try to nab Fredette with the 12th pick.
4. Cleveland
Jonas Valanciunas
Position: C
Height: 6-10
Weight: 230
Age: 19
Country: Lithuania
Analysis: I've had Kanter in this position since Mock Draft 1.0, but it's time to make the biggest change I've made to our board. From what I gather, the Cavs appear to be cooling a bit on Kanter and warming to Valanciunas.
Vesely and Leonard are in the picture too and would both be good fits. But this may be the Cavs' only chance to draft a legit 7-foot center. Valanciunas is raw, but he has big upside.
5. Toronto
Jan Vesely
Position: PF
Height: 6-11
Weight: 240
Age: 21
Country: Czech Republic
Analysis: Bryan Colangelo could go a number of directions here. He has strong interest in both Brandon Knight and Kemba Walker. If Knight is on the board, I think he doesn't get past here. If just Walker is here, the question for Colangelo is what to do with Leandro Barbosa and Jerryd Bayless. Both players are similar to Walker.
The Raptors could go with an international player such as Kanter, Valanciunas, Vesely or Bismack Biyombo. Of the four, sources say, Vesely is the highest on their board.
6. Washington
Enes Kanter
Position: C
Height: 6-11
Weight: 260
Age: 19
Country: Turkey
Analysis: The Wizards know they aren't taking a point guard -- not with John Wall in the fold. So the questions are: Who's the best player on the board and what do they need? The Wizards are very high on Vesely, but in this mock he's off the board.
Kawhi Leonard is an option. He brings toughness, defense and versatility to a team that can use all three attributes. But the Wizards are really looking for rebounding help up front and Kanter is a very good fit here. He's tough, he isn't afraid to be physical and he has good size. Tristan Thompson is a dark horse here as well.
7. Sacramento
Kawhi Leonard
Position: SF
Height: 6-7
Weight: 228
Age: 19
School: San Diego State
Analysis: If the draft plays out this way, the Kings could go in three different directions. They could go with Leonard, who would help solve a major need at small forward or they could choose between Walker and Fredette at the point. We've had Walker in this position for weeks, but mostly because we've had Leonard off the board.
Fredette, as we've been writing for the past two weeks, is the dark horse here. The Maloof brothers love him and he's probably a better fit in the Kings' backcourt than Walker. If Leonard is off the board, Fredette could be the pick.
8. Detroit
Kemba Walker
Position: PG
Height: 6-1
Weight: 184
Age: 21
School: UConn
Analysis: For the past few weeks, we've had the Pistons taking Valanciunas, but with Valanciunas now going No. 4, it looks like the Pistons will be down to three prospects: Kemba Walker, Tristan Thompson and Bismack Biyombo.
Walker is the safe pick, though he doesn't actually fill a major need. Thompson has upside. And, from what I gather, the team is still very high on Biyombo. The Pistons know how to develop a defensive stopper like him and I'm told their trip to Spain to see him went well.
Still, at the end of the day, I think the Pistons draft the best player available, Walker, and look at moving Rodney Stuckey to the 2.
9. Charlotte
Marcus Morris
Position: PF
Height: 6-9
Weight: 230
Age: 21
School: Kansas
Analysis: The Bobcats haven't been the greatest drafters the past few years. Michael Jordan is determined to change that. The thinking in Charlotte is to not take big risks. To go with a proven product. To aim at the double instead of the home run.
Morris, with his versatility, toughness and Kansas pedigree is a very good option. Klay Thompson, Chris Singleton and Jordan Hamilton are all in the mix as well.
10. Milwaukee
Klay Thompson
Position: PG
Height: 6-7
Weight: 206
Age: 21
School: Washington St.
Analysis: I think this pick likely comes down to Thompson and Alec Burks. They play the same position, but have different strengths. Thompson is a shooter, Burks is a slasher.
With the Bucks telling me pretty strongly that they're holding on to Brandon Jennings as their point guard, and with the team making a strong drive to get back in the playoffs, I think Thompson is a better fit.
11. Golden State
Bismack Biyombo
Position: PF
Height: 6-9
Weight: 243
Age: 18
Country: Congo
Analysis: Jerry West is a fan of Klay Thompson and would likely select him if he's still on the board. But if he and Marcus Morris are off the board, the Warriors could be the team that takes a chance on Biyombo. The team desperately needs to improve its defense, shot-blocking and rebounding. Biyombo has the tools to do that right away.
12. Utah
Chris Singleton
Position: SF
Height: 6-9
Weight: 230
Age: 21
School: Florida State
Analysis: We've had Singleton here for weeks and we're not moving him unless the Jazz draft a forward with the No. 3 pick. With Andrei Kirilenko heading into free agency, the Jazz are going to want a defensive stopper who can guard multiple positions.
Tristan Thompson, Jimmer Fredette and Alec Burks are all possibilities here too.
13. Phoenix
Alec Burks
Position: SG
Height: 6-6
Weight: 193
Age: 19
School: Colorado
Analysis: The Suns are in that awkward spot between pushing for the playoffs and rebuilding. Lon Babby says the team will be emphasizing defense and Tristan Thompson could be a solid direction to go.
But if Burks is on the board, he may be very hard to pass up on. He has star potential if he ever learns how to shoot. With Vince Carter likely out of the picture in Phoenix, Burks also fits a need.
14. Houston
Nikola Vucevic
Position: C
Height: 7-0
Weight: 260
Age: 20
School: USC
Analysis: Could Vucevic really go this high? That's the word among a number of NBA GMs who are raving about his workouts. Some have argued that the differences between him and Enes Kanter are very slim.
With the Rockets in desperate need of some size in the paint, Vucevic could be the answer. He's not the world's greatest athlete, but he is skilled, has an NBA body and is ready to play now.
15. Indiana
Jimmer Fredette
Position: PG
Height: 6-3
Weight: 196
Age: 22
School: Brigham Young
Analysis: The Pacers could go a number of different ways here, but for the third straight week I think Fredette will be their man. There's a good chance that Jimmer is off the board when they draft, but if he's here, he'll be very hard to pass up.
Tristan Thompson and Markieff Morris are all also serious options here as well if both are still on the board.
16. Philadelphia
Tristan Thompson
Position: PF
Height: 6-9
Weight: 228
Age: 20
School: Texas
Analysis: Thompson could go as high as No. 5 or No. 6. But he also could slide. Just about every team I spoke to likes him a lot, but I've yet to find the team that's fallen in love. I doubt he slips further than this though. The Sixers need more size, toughness and rebounding. Thompson provides all three. Jordan Hamilton and Markieff Morris are also options here.
17. New York
Marshon Brooks
Position: SG
Height: 6-5
Weight: 195
Age: 22
School: Providence
Analysis: The Knicks are really hoping that either Klay Thompson or Jimmer Fredette fall to them. But if they don't, watch out for Brooks. He had a great workout in New York, has the sort of swagger that Knicks guards need and the Knicks were wowed by his ability to pass the ball too.
Brooks, at 22, doesn't have the upside of a guy like Josh Selby, but his size advantage is big and so is his ability to step in and play right away.
18. Washington
(via Atlanta)
Jordan Hamilton
Position: SF
Height: 6-9
Weight: 229
Age: 20
School: Texas
Analysis: Hamilton is often compared to Wizards small forward Rashard Lewis. Both are big men with sweet strokes that can catch fire. But with Lewis on the back end of his career and the Wizards actively shopping him, I don't think the team will shy away from adding another scorer to put around John Wall.
19. Charlotte
(via New Orleans)
Markieff Morris
Position: PF/C
Height: 6-9
Weight: 241
Age: 21
School: Kansas
Analysis: The Bobcats have needs just about everywhere and Morris should be a good fit. He's strong, he's defensive minded, he rebounds and he blocks shots. He's a bit undersized to play the 5, but his ability to stretch the floor will be welcomed.
20. Minnesota
(via Memphis)
Donatas Motiejunas
Position: PF
Height: 7-0
Weight: 220
Age: 19
Country: Lithuania
Analysis: The Wolves have the best group of international scouts in the NBA and if Motiejunas falls this far, I think they'd snap him up here. He's an aggressive scorer and has size -- two things the Wolves could use in the post.
Marshon Brooks, Kenneth Faried, Nikola Mirotic and Charles Jenkins are also possibilities.
21. Portland
Kenneth Faried
Position: PF
Height: 6-8
Weight: 225
Age: 21
School: Morehead State
Analysis: The Blazers fell in love with Faried last year before he withdrew from the draft. If they are fortunate enough to get a second chance at him this year, they'll grab him. His relentlessness on the boards is a nice complement to LaMarcus Aldridge's more offensive-minded style.
Markieff Morris, Tobias Harris, Darius Morris, Reggie Jackson are other players to watch.
22. Denver
Tobias Harris
Position: PF
Height: 6-8
Weight: 223
Age: 18
School: Tennessee
Analysis: Harris may be one of the more underrated players in the draft. He can play both the 3 and 4, and he has a very high basketball IQ and an NBA body. Harris doesn't do any one thing at an elite level, but he is one of the most well-rounded players in the draft.
Charles Jenkins, Iman Shumpert and Tyler Honeycutt are other possibilities here.
23. Houston
(via Orlando)
Darius Morris
Position: PG
Height: 6-4
Weight: 190
Age: 20
School: Michigan
Analysis: We have the Rockets going big with pick No. 14 and we have them going big again at No. 23. Morris is a different kind of big. He's a point guard who towers over the competition. If he were a better shooter he'd be going much, much higher in the draft. But at this point he's a steal.
24. Oklahoma City
Nikola Mirotic
Position: SF
Height: 6-10
Weight: 226
Age: 21
Country: Serbia
Analysis: Sam Presti is an opportunist, and he is patient -- two critical traits in a great GM. Mirotic, based on talent, is a lottery pick. But a massive buyout means he won't be playing in the NBA anytime soon. Mirotic shocked NBA teams by deciding to stay in the draft.
It will likely take him three years to actually make it to the NBA, but given the talent level, the Thunder could be getting a major steal down the road. If Mirotic is off the board, Davis Bertans and Bogan Bogdanovic are possibilities.
25. Boston
Jeremy Tyler
Position: C
Height: 6-11
Weight: 263
Age: 19
Team: Tokyo Apache
Analysis: The Celtics are going to start rebuilding soon and they need to hit a home run again the same way they did with Rajon Rondo. Tyler could be that guy. If he had played in college, he might have had a chance to be a top-10 pick with his talent.
He's long, athletic and raw, but if he succeeds, he could be a major pickup for the Celtics. JaJuan Johnson, Justin Harper and Jon Leuer are also possibilities.
26. Dallas
Josh Selby
Position: PG
Height: 6-3
Weight: 195
Age: 20
School: Kansas
Analysis: The Mavs have won the title, but now it's time to begin thinking about the future. While the Mavs may have one more long run in those veteran legs, it's unlikely. Selby, like Tyler, could be a home run if he's developed right. His ability to get to the basket is really unmatched.
27. New Jersey
(via L.A. Lakers)
Reggie Jackson
Position: PG
Height: 6-3
Weight: 208
Age: 21
School: Boston College
Analysis: Yes, the Nets have Deron Williams. But he's not a sure thing to stay in New Jersey after next season. Even if he does, Jackson would be a terrific backup and a player who could play off the ball in certain situations.
Had he not had a knee injury when the predraft process began, he could've gone much higher. He's great value here. Justin Harper, Tyler Honeycutt, JaJuan Johnson and Jeremy Tyler are all options here too.
28. Chicago
(via Miami)
Justin Harper
Position: PF
Height: 6-9
Weight: 228
Age: 21
School: Richmond
Analysis: Harper was one of the best stretch 4s in college basketball last season. He also has size and is a pretty good athlete. The Bulls need perimeter shooting and Harper should be able to give them some.
Charles Jenkins, Tyler Honeycutt and Jeremy Tyler are also possibilities.
29. San Antonio
Davis Bertans
Position: SF
Height: 6-10
Weight: 210
Age: 18
Country: Latvia
Analysis: The Spurs have done a good job over the years of finding young international players and stashing them overseas for a few years until they're ready.
Bertans showed he can be a big-time shooter at the Nike Hoop Summit and adidas Eurocamp. At 18, he's worth taking a flier on and seeing what he can accomplish after another year or two in Europe.
30. Chicago
Tyler Honeycutt
Position: G/F
Height: 6-8
Weight: 188
Age: 20
School: UCLA
Analysis: The Bulls need scorers in their backcourt and ultimately need to find a backup for Derrick Rose at point guard. Honeycutt wasn't a dominating scorer in college, but his versatility should make him a nice fit in Chicago.
Next Five In: JaJuan Johnson, F, Purdue; Charles Jenkins, G, Hofstra; Nolan Smith, G, Duke; Jordan Williams, F/C, Maryland; Chandler Parsons, F, Florida


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Mr Solt thanks for the heads up.
Sorry fellas I kinda been backed up wit orders as it is and have not had much time to get on here and didn't see this thread was back in action. I will pm each of you interested and we can go from there. As I said a little backed up right now but I will be sure to spread the mini love as much as I can! PM's will be coming tonight or tomorrow morning.


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|Sorae Igarashi
|Mid 30s (Deceased)
| Ganta Igarashi (Son)
National Medical and Health Center
|First Appearance
|Manga debut
|Chapter 1
|Anime debut
|Episode 5 (briefly seen)
Sorae Igarashi was the mother of Ganta Igarashi. She was a doctor and was involved in the development of the Wretched Egg as well as the Mother Goose System. She died by committing suicide. Sorae couldn't bear the guilt of turning Shiro into a monster. In the anime, Ganta explains that ten years before going into Deadman Wonderland, his mother had died.
Sorae has long black hair that is kept in a braid over her right shoulder. She wears regular clothes; a green sweater and light pants. Over her clothes she wears a white lab coat. She is always seen walking with sandals on.
Sorae was initially a harsh individual, as noticed by Hagire Rinichirō in their days working together at the institution. She was willing to do anything for the purpose of science and reacted coldly towards her research subjects, even giving birth to Ganta for the sole purpose of using him as the subject for her experimentation. Her personality changed after the birth of her son. Overcome by motherly instinct, she could no longer stand the thought of using him as a guinea pig and quickly sought another infant to use as a substitute.
Despite having intended to experiment on them both, Sorae seemed to be a loving and caring mother to Ganta and Shiro, having lost the heart to experiment on her own child, while despising herself for the things she and Hagire did to Shiro in the name of research. While outside of the lab, she treated her like her own daughter and gave her presents and treats just like she did with Ganta, and often cried to herself when forced to carry out the experiments. As a last glimmer of hope to save Shiro, she created the Mother Goose System along with the lullaby that would seal away the destructive powers of the Wretched Egg.
HistoryOver fifteen years before the main story, Sorae Igarashi worked as a professor for the Medical Center in Tokyo alongside fellow scientist Hagire Rinichiro. The team participated in a variety of research ventures on the human body, and subjecting both the living and dead to immoral experiments. When confronted with the need of a living subject for their next experiment, Sorae recommended her own unborn child as the next scientific commodity, her level of callousness even surprising the equally cold-hearted Hagire. This changed when Ganta was born. As her maternal instincts quickly surfaced, she unexpectedly developed an attachment to her son and could not bring herself to involve him in her experiments. Sorae went on to obtain another baby to replace Ganta in her research. She adopted an orphaned albino infant and brought the baby to the laboratory. Hagire notices the hair color and immediately figures out that the new child is not Ganta. But Sorae tearfully refused to give up her child and presented the albino child to use for the experiments instead. The white-haired child is later given the name Shiro.
Sorae lived together with Ganta and Shiro at the medical institution where she and her team conducted research to heighten a human's immune abilities, their "guinea pig" for this research being Shiro. Over the years she developed a bond with the young albino girl, treating her as a daughter and giving her presents and treats while not performing experiments. When Shiro became irritated playing with Ganta due to his weakness, Sorae was forced to remind Shiro of her enhanced strength and endurance. Although her emotional attachment to the albino girl caused Sorae to despise her team's experiments, she continued working alongside Hagire. Hagire became sickly interested in Shiro and prompted Sorae to continue with their endeavors. Due to the inhumane and brutal experiments preformed on Shiro, the albino girl's mind developed a second personality to deal with the pain. The research ultimately gave birth to the Wretched Egg.
Following the awakening of Shiro's destructive personality, Ganta's mother composed a lullaby capable of suppressing the evil within her. She would often play this song on the piano for Ganta and Shiro with tears in her eyes, knowing the true purpose of the melody and what must eventually be done. At the time Sorae was completely destroyed knowing what she had done to Shiro. She often cried and played her piano singing different versions of the lullaby. When The Wretched Egg could no longer bear the pain and caused the Great Tokyo Earthquake, Sorae sent Ganta to live with his father, knowing that Shiro's suffering was her responsibility. Having removed Shiro from Ganta's memories, he does not recognize the name of his friend when mentioned by his mother. Knowing that he would be better off not knowing, she simply tells him to take care.
Hoping to lock away the alternate personality forever, Sorae created the Mother Goose System, an invention that constantly emanated the lullaby in order to keep Shiro from succumbing to the Wretched Egg's influence. She then sealed the machine to prevent anyone from tampering with it, leaving behind a hidden journal explaining how to operate the device. An injured Hagire later confronts Sorae about releasing the Wretched Egg after the earthquake, but she refuses to give him that information. Sorae then pulls a gun from her lab coat and kills herself.


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TALENTED children from across the UK have been awarded at this year's Young Writers' Poetry Competition.
A special ceremony was held on Saturday (June 28) to celebrate children's achievements from a number of Hampshire schools as part of this year's 34th Winchester Writers' Festival.
Entrants were asked to write food-themed poems in a bid to encourage children to challenge the written word.
Judith Heneghan is the festival director and the University of Winchester's programme leader for the MA Writing for Children course.
She said: "The competition is a wonderful way to support and encourage young writers to experiment with poetry. The winning entries are polished pieces, highly original in both language and approach.
"Attendees came from all over the UK and around the world to share ideas and creative work, and the beautiful weather meant people could congregate and listen to readings outside. I've also been told that several new writers have been offered representation by the literary agents they met here."


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Heifer's India Adventure
7 Jan 2013 at 03:47
Tom spent this week with Aunty Kamlesh in her village in Rajasthan, India. It was so so hot! Kamlesh is a unique lady in her village. She is a member of a group that received goats as a gift from another group of women. Passing on the gift of animals from family to family is a big part of how Heifer International works to end hunger and poverty around the world.
With Flat Friend


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Does anyone know a forum/website where I can ask few questions from John Peacock. I searched the web but could not find any such place. So I thought about asking this community where I learned about him.
As he is neutral about reincarnation, I want to know his opinion on Dr. Ian Stevenson's research and about Edgar Cayce life readings.
If any of you have any opinion about above I like to see them all.


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Within one day, the Lakers' most pressing questions veered from how quickly they'd learn the Princeton-based offense to who will become their head coach.
The Lakers believed they solved the former problem by firing Coach Mike Brown on Friday following a 1-4 start, confusion over a revamped offense and uncertainty on when and if that would change.
"It's hard to say and sit here and predict how this season would've turned out if he had a full season," Lakers General Manager Mitch Kupchak said in press conference at the Lakers' practice facility in El Segundo. "It could've turned out just fine. But we were not willing to take that chance."
The Lakers plan to address the latter problem by hiring a new coach, "the sooner, the better." Kupchak said he won't require "championship experience." He conceded there's a remote possibility the candidates would be NBA assistant coaches.
When asked if players would be consulted about the hire, Kupchak said "maybe." No players, including Kobe Bryant, were consulted about Brown's hiring in May 2011.
Some candidates could include former Knicks Coach Mike D'Antoni, former Utah coach Jerry Sloan, former Portland coach Nate McMillan and former Lakers assistant and current Pacers assistant Brian Shaw. But Kupchak only addressed one candidate by name.
"When there's a coach like Phil Jackson, one of the all-time greats and he's not coaching, you'd be negligent not to be aware that he's out there," Kupchak said. "We're putting together our list and attack plan. We have not reached out to anybody at this time."
Jackson won six of his 11 NBA championships in two separate coaching stints with the Lakers (1999-2004, 2006-2011). Jackson currently lives in Los Angeles during the NBA season with his longtime companion, Jeanie Buss, Lakers executive vice president of business operations. Jackson is also said to be in much better health in his knees and hips and rejuvenated after spending the past NBA season enjoying retirement. Still, Jackson had said during his last season that he had no interest in experiencing the grind of an NBA season.
One report indicated center Dwight Howard told the Lakers he wants them to hire Jackson. But he denied such an assertion before entering the players' lounge before the Lakers (1-4) played the Golden State Warriors (3-2) Friday night at Staples Center.
"I don't want to talk about that," Howard told this newspaper. "I didn't tell anyone anything."
The Lakers say they told Brown about his firing about 9:30 a.m. on Friday, after the team's front office in owner Jerry Buss, vice president of player personnel Jim Buss and Kupchak mulled for over the past day whether they'd pull the trigger.
The Lakers, who currently field a $100 million payroll, decided to do so despite the financial ramifications. Brown had about $10 million left on his contract. He had another guaranteed year remaining and a partial guarantee in 2013-14.
His departure came quicker than former Lakers Coach Del Harris, who was fired 12 games into the 1999 season.
"I have great respect for the Buss family and the Lakers' storied tradition and I thank them for the opportunity they afforded me," Brown said in a statement. "I have a deep appreciation for the coaches and players that I worked with this past year and I wish the organization nothing but success as they move forward."
Bernie Bickerstaff, Brown's longtime mentor since hiring him as an unpaid intern in 1992 with the Denver Nuggets, will coach the Lakers on an interim basis. Meanwhile, Lakers assistants Eddie Jordan, Steve Clifford, Darvin Ham and Chuck Person will stay until further notice.
"You're being kind with the word surprised," Bickerstaff said. "I was shocked."
Plenty of the Lakers' players expressed similar sentiments.
In a video that has since gone viral, Kobe Bryant epitomized the Lakers' frustration with a so-called "death stare" during the waning seconds of the Lakers' 95-86 loss Wednesday at Utah. The general public presumed Bryant directed his cold expression toward Brown, but he emphatically denied it.
He also reverted to his Facebook page shortly after Brown's firing became official.
"I had a good relationship with Mike and I will continue to have one," Bryant wrote on his Facebook page. "I wish him and his family nothing but the best. I spoke with him today and thanked him for all of his hard work and sacrifice."
But that wasn't enough.
The Lakers hired Brown in May 2011 following Jackson's retirement, walking away impressed from his job interview with his meticulous work ethic, defensive background and ability to carry the Cleveland Cavaliers to a 272-138 record. His tenure in Cleveland included the 2009 NBA Coach of the Year award, an NBA Finals appearance and two Eastern Conference Finals appearances before getting fired after the 2009-10 season.
Yet, Brown entered his first season with circumstances that Kupchak conceded made him give him a "free pass." That's because Brown led the Lakers to the Western Conference semifinals through unique circumstances, including the lockout-shortened year, the nixed Chris Paul trade, the loss of Lamar Odom and Pau Gasol "feeling scarred for the whole year" over persisting trade rumors.
The Lakers were hardly as patient with their sluggish offense and defense, even if injuries to Bryant (right foot), Steve Nash (fracture in left leg) and Howard (surgically repaired back) limited the starting lineup to only one preseason appearance and two regular-season games.
"It's a pretty direct message to all of us that there's no messing around," Gasol said. "It's time for us to step it up and have respect and appreciation for how hard Mike worked and how much he strived for this team to do well."
They will have to take that approach under different leadership, a move one prominent Laker believed was necessary.
"They must turn to Phil Jackson," Magic Johnson said on ESPN. "I don't know if Phil wants to coach or not, but this team is built for a Phil Jackson-coached team. They have the size and he knows what to do offensively and defensively with the Lakers. The fact that now he has a point guard like Steve Nash, Coach Jackson will know what to do with this team."