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KENDALL, Fla. - Police say a teenager was taken to the hospital in critical condition Wednesday after being shot inside a home in Kendall.
Witnesses said the incident began after 5 pm with a neighbor rushing into a townhouse to help a mother with her bleeding child.
"I was worried and alarmed," said Maria Balloveral, a neighbor. "As a mom, it's pretty scary."
"He was all bloody, on his shirt," another neighbor said.
After six hours of investigating, police said they are still unsure of how or why the shooting occurred. They believe there could be two teens and an adult involved.
"They're still trying to determine whether it was accidental, or exactly what was the reason the firearm went off." said Det. Alvaro Zabaleta of the Miami-Dade Police Department.
Police said they are questioning everyone who was inside the home at the time, but have not yet identified anyone.
Neighbors said two 13-year old brothers live there with their mother, but are unsure of anything else.
"My prayers are with the child and the mother as well," said Balloveral.
Police said the teen was taken to Miami Children's Hospital where he is listed in critical condition. No other injuries were reported.
The shooting is still under investigation. Stay with Local 10 as this story continues to develop.
Copyright 2013 by Local10.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Pettibone cruises in strong start; homers pace Phils
Frandsen, Brown go deep; Mayberry chips in three RBIs on 3-for-4 night
PHILADELPHIA -- Cliff Lee suggested the Phillies show a little more pride in their work following a brutal trip to Cleveland a couple weeks ago.
"They really took it to us," Phillies second baseman Kevin Frandsen said following a 6-2 victory Tuesday over the Indians at Citizens Bank Park. "They just kicked our butt. You would hope the guys would realize that, and I feel like we did. The last thing you want to do in any sport, it doesn't matter if it's baseball, basketball, hockey, you don't want to get embarrassed. I feel like maybe we got embarrassed over there."
The Phillies were outscored in that two-game series at Progressive Field, 20-2, and they tried to make amends with a few clutch hits, more quality pitching from Jonathan Pettibone and a few nice performances from the bullpen.
Things started quickly when Frandsen hit a solo home run to left field in the first inning to give the Phillies a 1-0 lead. Frandsen, who started in place of Chase Utley, is hitting .467 (7-for-15) with one double, two home runs and four RBIs against lefties this season. He hit .400 (26-for-65) with six doubles, two triples and two RBIs against left-handers last season.
Maybe Phillies manager Charlie Manuel will find a way to get Frandsen into the lineup more often against lefties.
The Phillies had runners on first and second with one out in the fourth when John Mayberry Jr. ripped a double to center field to score Domonic Brown and Carlos Ruiz to hand the Phillies a 3-2 lead. Mayberry started in center field in place of Ben Revere, as Manuel inserted a couple of right-handed hitters in the lineup against Indians left-hander Scott Kazmir.
The moves worked.
Brown smacked a home run to right field in the sixth to make it 4-2. It was Brown's seventh homer of the season, which pulled him into the team lead with Utley. Brown is hitting .314 (11-for-35) with one double, three home runs and seven RBIs against lefties.
But Pettibone came up just as big as Frandsen, Mayberry and Brown. He allowed two runs in the second to give the Indians a 2-1 lead, and he appeared to be on the brink of disaster in the third when he walked Jason Kipnis, then hit Nick Swisher and Carlos Santana to load the bases with two outs. But he got Mark Reynolds to pop out to Frandsen to end the inning.
Pettibone retired 11 of the final 13 batters he faced.
"It's big escaping with no runs, especially after that second inning giving up two," Pettibone said.
Pettibone allowed four hits, two runs, two walks and struck out three in 6 2/3 innings, the longest outing of his short big league career. He improved to 3-0 with a 3.41 ERA in five starts.
"I thought he did a good job, unfortunately," Indians manager Terry Francona said. "When he needed to, he got a double play. He kept us off balance. We didn't square up on a ton of balls. I thought he pitched a pretty good game."
Pettibone's composure has impressed Phillies manager Charlie Manuel and his teammates.
"Beyond anything," said Frandsen, when asked about Pettibone's poise.
Frandsen recalled working out in Clearwater, Fla., during a 50-game suspension in 2011. He got to watch three of the Phillies' top pitching prospects at the time: Jarred Cosart, Trevor May and Pettibone.
"The first thing I said when I came back to [Triple-A] Lehigh [Valley] is that kid [Pettibone] was the best of the three," Frandsen said. "They talked about the big three. He was 19, 20 at that time. That's different, especially in A-ball where if you have good stuff, you can go for the strikeout all the time. He was worried about going deep in the game."
Manuel pulled Pettibone with two outs in the seventh for left-hander Antonio Bastardo, who got out of the inning. But after Bastardo put runners on the corners with one out in the eighth, right-hander Justin De Fratus, who was called up from Triple-A over the weekend, got Reynolds to pop out. Left-hander Jeremy Horst then struck out Michael Brantley to end the inning.
"I said a couple of days ago in Arizona that those are the spots that you want to be in as a reliever," De Fratus said. "You want to go out there and attack the zone and hope for the best."
Todd Zolecki is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.

subset: commoncrawl


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PENSIONER Ray Butt has warned fellow computer users to take extra care after being caught up in a new phone scam.
Ray, 72, of Lydiard Millicent, found his computer completely scrambled by hackers after receiving a call from what he thought were representatives from Microsoft.
Fortunately, he clocked on to the scam before parting with any cash but not before the hackers had gained access to his device.
The keen jazz musician now wants to warn others of the dangers.
Ray said: "I was at home when I received a call from a lady who said she was from Microsoft. I said I was not available at that moment in time and left it there but she called back later.
"She said my PC was registering a number of errors and my machine would eventually slow up and close down. I asked her 'How do I know you're from Microsoft?' but she was very convincing and knew how to hold a conversation."
Believing the woman was from the computer company, he followed her instructions to press several keys on the keyboard and almost straight away the hackers had access to Ray's computer.
"There were numbers and letters scrolling across the screen and they appeared to be performing a scan of some sort which eventually finished, claiming there were 7,023 errors in my computer," he said.
"I was then passed on to a man who asked me to type in 5143 to look at the errors and find out how to fix them. I was taken in. Looking back I could kick myself."
It was at this point the caller said Ray could pay for protection from the problems with several options, ranging from one year's cover to lifetime coverage.
Ray indicated that should he buy an option it would be the lifetime option but he would not be doing so there and then. The caller then became quite persistent in asking him how he would pay.
After several minutes Ray hung-up but received several calls from them throughout the afternoon.
"My computer was completely gone at this point so I shut it down," said Ray.
"I phoned PC World after the first call and they were extremely helpful. They explained to me that this is a regular issue and there are a lot of cases like this.
"I just want people to be aware of the problem and to take care. It is very easy to fall for."
Luckily for Ray, PC World was able to talk him through how to reset his computer and it is now working again, but Trading Standards has warned computers users to be aware as tracing the perpetrators is difficult.
A spokesperson for Trading Standards said: "They are hard to tackle as the scammers are often from places like India or China which makes it extremely difficult to trace them, let alone deal with them.
"The best line of defence is for people to be aware of them and not to be taken in. The scammers are plausible and can contact you either by email, or by phone. "Once they have access to your computer, they can steal information or hold it to ransom."


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We've been featuring our new mid-century modern American furniture by Copeland lately so when I came across this article about a beautiful new luxury mid-century Vermont home, I thought I'd share it with you.
The former Vanderbilt estate that sits along the edge of Lake Champlain now belongs to a Manhattan couple who've used natural materials including reclaimed barnwood and local river rocks to create a rural respite quite reminiscent of the homes of American architect Frank Lloyd Wright.
Find a dozen more photos of this modern luxury retreat at The Globe and Mail.
Already following our Blog? For more info sign up for our e-newsletter
This blog is written by your friends at Vermont Woods Studios. Check out our Vermont made furniture and home decor online and visit our showroom and art gallery at Stonehurst, the newly restored 1800s farmhouse nestled in the foothills of the Green Mountains.


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Which engine will score the most points in 2012?
This topic contains 17 replies, has 12 voices, and was last updated by Kingshark 4 years, 8 months ago.
8th February 2012, 11:38 at 11:38 am #130890
I've asked this same question ahead of both the 2010 and 2011 seasons as someone with an interest in manufacturer involvement in F1: Which engine will score the most points this year?
In 2010 almost everyone correctly predicted Mercedes would come out on top.
Mercedes – 736 points
Renault – 661 points
Ferrari – 453 points
Cosworth – 69 points
In 2011 Renault were ahead for most of the year, but finally the most-popular pick Mercedes eventually won by just 8 more points.
Mercedes – 731 points
Renault – 723 points
Ferrari – 460 points
Cosworth – 5 points
What do you think will happen this year?
Here are the contenders:
Mercedes – McLaren, Mercedes, Force India
Renault – Red Bull, Lotus, Williams, Caterham
Ferrari – Ferrari, Sauber, Toro Rosso
Cosworth – HRT, Marussia
The big change on this front is Williams switching to Renault. Mercedes engines have generally got ahead of Renault engines thanks to having Force India as a strong third team. If Williams have a good year (like 2010) then Renault could come out on top. Also, Caterham may start to pick up points.
But will Cosworth score any points this year with just HRT and Marussia?
My view is that Red Bull can't repeat what they did in '11, and McLaren will probably have a better season in '12, which should do enough to bring Mercedes out on top.
Tell me what you think!8th February 2012, 11:50 at 11:50 am #192215
Think I agree with Mercedes. I expect to see Force India outscore Williams and possibly Lotus and Mercedes to beat Lotus. Then unless Red Bull completely ran away with it again (unlikely) I think they won't get enough points over McLaren to make up the difference for Renault.8th February 2012, 12:09 at 12:09 pm #192216
Mercedes should be the most likely option. McLaren and Mercedes should be among the best teams and ForceIndia should establish itself as one of the best midfield teams. Unless Lotus surprises us immensely that should be enough to fend off Renault.
Or how about a surprise awesome Sauber, fighting for the podium while Ferrari have a 2002/04 season :-D .. I know, won't happen.
So I say Mercedes too.8th February 2012, 12:35 at 12:35 pm #192217
They have two teams that are well and truly in the midfield and will frequently be in the points. I don't have that same confidence in either Caterham or Williams, and I'm not sure whether Lotus will be as competitive this year with a car that isn't designed around a trick exhaust system.
Also considering that Mercedes still scored more points in 2011, despite Red Bull having their most dominant season to date. Unless 2012 is dominated to an even greater extent by Red Bull, it's unlikely that Renault engines will collect more points, in my opinion.8th February 2012, 13:15 at 1:15 pm #192218
I think Mercedes will top the table again but this is very dependent on the year the williams have, i think last year for them was a serious blip which wont be repeated this year.
I dont think red bull will dominate the season so much this year but they are still where i would put my money for the constructors.
Cosworth is a dying manufacturer and to be honest has lost its reputation, i think next year(2013) you wont see them in the sport and unless we get a wet race with a big crash they wont get any points this year however much i want Marussia to score some :)8th February 2012, 13:43 at 1:43 pm #192219
If I had to put money on it, I'd go for Mercedes, but as this is just a bit of fun and Mercedes have already been picked a few times, I'll be the first to say Renault. Red Bull will probably finish above McLaren, Lotus could get very close to the Mercedes team itself, and although neither Williams or Caterham fill me with confidence, between them they could edge Force India, particularly if the "big four" becomes a "big five" with Lotus closing the gap to Mercedes and making it very difficult for other teams to score points regularly.
I'd be extremely surprised if Cosworth picked up any points this year.8th February 2012, 20:12 at 8:12 pm #192220
I don't expect Red Bull to be as competitive in comparison to the rest of the field this year, however I think they will be the only team powered by Renault engines to win. I expect McLaren to win races, and I think Mercedes will start winning race this year. On that, I think Mercedes will be the top engine supplier of 2012.8th February 2012, 23:26 at 11:26 pm #192221
no way is cosworth scoring any points this year. inferior to the competition in every way, as are the only 2 teams using it.
it's a shame the rules prevent development and variety across the entire car, but especially the drivetrain. what happened to the motor being the heart of a car?28th August 2012, 18:36 at 6:36 pm #192222
Half-way (ish) standings:
Renault: 246 + 192 + 53 + 0 = 491
Mercedes: 193 + 106 + 46 = 345
Ferrari: 189 + 80 + 6 = 275
Cosworth: 0 + 0 = 0
Even if Renault's score was multiplied by 3/4 to make it a fair comparison with Mercedes and Ferrari, they'd still be in the lead. And I was the only one to go for Renault!28th August 2012, 20:17 at 8:17 pm #192223
Reading my prediction now is quite funny…28th August 2012, 20:22 at 8:22 pm #192224
This is unfair, Renault supply four teams.
Nonetheless, Caterham are a non-factor anyway.28th August 2012, 20:53 at 8:53 pm #192225
Just read bananarama's prediction:
Unless Lotus surprises us immensely that should be enough to fend off Renault.
Or how about a surprise awesome Sauber, fighting for the podium
He may have thought he was crazy but both of these things happened. Sauber and Lotus are both amazing this year.28th August 2012, 21:11 at 9:11 pm #192226
I suspect Renault will also be the winning engine this year29th August 2012, 0:37 at 12:37 am #192227
Why is everybody saying Mercedes? Renault will clearly win! Think about it. Red Bull will almost certainly beat McLaren, Lotus will definitely beat Merc, and Williams have the edge over Force India.29th August 2012, 0:52 at 12:52 am #192228
@brazil2007 All these predictions were made pre-season.
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Now if the Pacers lose 10 out of their next 11 games we can talk about a collapse. Just wanted to get your attention.
Just got back from the game, really bad game. I don't think I am going to anymore games this season, because the last three games I have gone to, Hornets, Rockets and Nets the Pacers have lost. For financial reasons I am going to a lot fewer games this season.
I have been to everyone of the Pacers home losses except the Celts loss, I saw them lose to the Bucks, Magic, Nets, Rockets, Hornets. In the 10 games I have gone to the Pacers are 5-5. Sorry.
Now let's talk about the game tonight.
You could see it from the opening minute, the Hornets were ready, the Pacers were still in Cancun.
The Hornets manhandled the Pacers in every way possible. Peck, I was thinking of you tonight as the Hornets basically just over powered the Pacers. The rebounding was ugly, part of it was because Baron Davis was getting into the lane with ease and the big men had to help but the other part of it wass Foster and J.O were just getting manhandled
Baron Davis was blowing by our guards with such ease and the help defense was thinking of babes in bikinis. If Baron would clean up his horrible shot selection, he would be the best point guard in the NBA and a top 5 player in the whole league.
Everytime J.O got the ball Armstrong left Tinsley and doubled, and Tinsley could not hit the shot. This concerns me as teams start to prepare more and more to stop the Pacers inside game, they will leave the points guard wide open.
There was a little Ron Artest incident tonight. In the third quarter, he re-injured his thumb when he fell on it, you could tell he was in a lot of pain, so the next time down the floor, Ron pulls something off of the stanchion on the basket closest to the Pacers bench. It was some type of wire. No other equipment was damaged. After this incident was when Ronnie started going to the basket with abandon and was getting fouled every time.
Overall, I am not too concerned about this game, I know Rick does not want to use the allstar break as an excuse, but it had an effect.


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STAGE TUBE: On This Day 11/12- GRAND HOTEL
Welcome to BWW's ON THIS DAY Series celebrating theatrical birthdays, openings and special events that took place on this day in theatre history!
Today in 1989, Grand Hotel opened at the Martin Beck Theatre (now the Al Hirschfeld Theatre) where it ran for 1017 performances. Grand Hotel is a musical with a book by Luther Davis and music and lyrics by Robert Wright and George Forrest, with additional lyrics and music by Maury Yeston. Based on the 1929 Vicki Baum novel and play, Menschen im Hotel (People in a Hotel), and the subsequent 1932 MGM feature film, the musical focuses on events taking place over the course of a weekend in an elegant hotel in 1928 Berlin and the intersecting stories of the eccentric guests of the hotel, including a fading prima ballerina; a fatally ill Jewish bookkeeper, who wants to spend his final days living in luxury; a young, handsome, but destitute Baron; a cynical doctor; and a typist dreaming of Hollywood success.
In celebration of this day, we bring you 'We'll Take a Glass Together' as performed at the 1990 Tony Awards. Click below to check it out!
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Started this discussion. Last reply by J Kat Renner Oct 22, 2012. 9 Replies 3 Likes
Hi,I am new to the community. Anyone on here in direct sales? I am looking to network with other direct sales reps. I would like for us to learn from each other and help motivate one another on our…Continue
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Hi Angie -- Welcome to the 48 Days community. We're glad you joined.
This is the idea and social networking site for people that want to create their own opportunity.
Depending on your interests, there is a wide selection of discussion groups to get involved with.
If you are interested in closing the gap between your passion and purpose, here is the link to ours, Powerful Living for Health and Wealth.
To make the most of your experience, visit our handy getting started tutorial page. You'll find how-to videos and suggestions.
48 Days advisory team
Hi Angie,
I'm back from an awesome conference last week, and I see you've joined in the process, so thought I'd stop by to welcome you to the amazing 48days community! Exciting that you're looking to move into more non-traditional and away from the 9-5...
Little background on me; I'm a long time member here, who truly believes in the 48 days vision and this community. I can truly testify that the power behind this community is a huge reason for my success and business.
So whenever I can, I like to reach out to see who I can help. If you have any questions, or you start feeling overwhelmed right off the bat, because there is just so much great content, discussions, and just lots of great stuff happening, feel free to reach out and let me know! I would love to help guide you here.
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Many blessings on your journey, and by all means… Enjoy the adventure!
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In a season built on the backs of freshmen, UCLA found an unlikely spark plug Saturday afternoon.
With the Bruins off to another slow start, it was the Wears who stepped in early at Pauley Pavilion. Travis scored the first seven points for the team, and David put in the next eight to open a 68-60 win over Stanford.
Shabazz Muhammad and Jordan Adams, the team's two leading scorers, finished the first half a combined 1 of 6 from the field.
The Cardinal (9-6, 0-2) scored the game's first four points, but UCLA's twins soon outpaced the entire opposing squad. David's 3-pointer six minutes in gave the Bruins (12-3, 2-0) a 10-8 lead it never relinquished.
The streak didn't end until Adams hit two free throws at 9:30.
The twins quieted down in the second half, combining to shoot 1 for 5 after the break. They also combined for just five rebounds in 50 minutes, a remarkable feat given they both stand 6-foot-10.
David's playing time has ticked down slightly in the past two games. Averaging more than 20 minutes on the season, he has played 13 and 17 in his past two outings. He and his brother are both below-average defenders - see Stanford forward Dwight Powell's 17 points and nine free-throw attempts - but they function well in UCLA's fast-paced offense.
"That's the team game plan now," said Muhammad, who eventually scored a game-high 23 points. "We have so many athletes who can run the break.
- Transition is our strength. We would love to run with a team all day, run and get easy layups."
Parker still bothered by back
Freshman Tony Parker, bugged by a variety of injuries this season, walked into the pregame layup line behind the rest of the team. The 6-foot-9 forward/center received acupuncture this week to help relieve back spasms.
Coach Ben Howland said the spasms affected Parker at the line Thursday night, when he missed two free throws against California. Parker nearly had an air-ball on a free throw near the end of Saturday's warm-ups. He entered the game at 9:30 in the first half, and exited two minutes later with a missed layup and a foul.
"I've just got to get him back in there where he's comfortable," Howland said.
Parker also missed Monday's practice with a migraine.
Close misses
In its Thursday loss at USC, Stanford missed a chance to force overtime when Powell, the Cardinal's leading scorer, missed a putback dunk at the buzzer. Two days after the 71-69 decision, another Cardinal forward repeated that play.
Junior Josh Huestis' slam attempt rattled out a little more than a minute into the game. Point guard Chasson Randle rebounded the miss, but immediately turned the ball over.
firstname.lastname@example.com twitter.com/thejackwang


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STOURBRIDGE professional dirt bike racer Steven Clarke slipped back to third place in the overall standings following a disappointing show in the Garmin Arenacross Tour which took place in front of 7,000 fans at Birmingham's LG Arena this week.
Clarke was forced to qualify for the main event via the last chance qualifier which left him with a poor gate for the race.
A philosophical Clarke said: "Starts are everything in Arenacross. Because I had to qualify for the main event through the LCQ, I got a bad choice of starting position, so I was always going to be chasing the race.
"But I'm still in third place overall and there are four rounds of the competition to go, so I've got the opportunity to catch up."
It was Frenchman Fabien Izoird who proved the big winner on the night, stretching his lead at the top of the Pro standings to 14 points, with Aussie rider Daniel McCoy moving up a place to second spot, overtaking Clarke in the process after following Izoird across the line in the final race of the night with Clarke coming home in ninth place.
Izoird now has 66 points to his tally, with McCoy on 52 while Clarke is a point adrift in third place.
The Garmin Arenacross now heads to Liverpool's Echo Arena this Sunday, which is the fourth stop in the seven round tour.
And Clarke has every reason to try to obtain top spot as there is a £100,000 prize for the overall winner.
The competition is Europe's biggest indoor motorcycle race series which is contested by an international field of 24 pro riders, who between them represent 10 different countries.
Clarke was holding second spot after the first two events of the series in Belfast and is determined to get back on track this week.


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A LACK of physicality in the forwards cost Swindon dear as they went down 15-12 away at Newbury Blues.
After the visitors slipped behind early on, Paul Daniels produced some magic as he broke away from the back of a scrum to touch down for a try which was converted by skipper Adam Westall to give his side the lead, but the visitors were soon behind once again.
Steve Price was able to convert a driving maul to bring the Greenbridge Road side back into the contest late on but it wasn't enough as they fell to defeat in their opening game of the year.
Swindon suffered a blow on Friday night when influential forward Tom Mannion was ruled out through injury, but the number eight still travelled to support his teammates and was able to give an objective view of the game.
"We had a good team out but we weren't clinical enough in the right areas despite playing well for certain parts of the game," he said.
"We need to be more physical up front, although our scrums and lineouts are up there with the best in the league, but when it comes to the breakdown we are a bit soft.
"If we can get that sorted we can give any team a run for their money, especially at home."
Despite the loss, Mannion insisted there were still a number of positives for his side to take.
"Obviously we wanted to win, so to lose was disappointing, although our defence stood up quite well," he said.
"If we can get back to our basics and our patterns I'm sure we can get back to winning ways."
Swindon take on South West 1 East leaders Oxford Harlequins at Greenbridge Road on Saturday.


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A Pilot Trial of Rituxan in Refractory Myasthenia Gravis
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- How to Read a Study Record
Myasthenia gravis is a disease that happens because the immune system attacks the nervous system. The damage is caused by antibodies produced by B lymphocytes. These antibodies damage a special part of the muscle that helps transmit impulses from nerves to muscles to allow muscles to work properly. This damage results in symptoms of myasthenia gravis. Participants are being asked to participate in this research study because their myasthenia gravis has either failed to respond to treatments commonly used in the disease, or they have had bad side-effects from such treatments.
This is a research study of a drug called Rituximab. Rituximab, also called Rituxan, is a mouse antibody that has been changed to make it similar to a human antibody. Antibodies are proteins that can protect the body from foreign invaders, such as bacteria and viruses, by binding to substances called antigens. Rituxan works by binding to a protein, called the CD20 protein. Rituxan helps to destroy white blood cells that produce antibodies in the body, called B-lymphocytes. It is a treatment given through a vein in the participant's arm over a period of approximately 4-6 hours. It has been approved by the Food and Drug Administration (FDA) for use in patients with a form of cancer of the lymph glands called Non-Hodgkin's Lymphoma (NHL). Rituximab is not approved for their myasthenia gravis.
Treatment with Rituximab is being tried in this research study because Rituximab decreases B lymphocytes. There is preliminary evidence that Rituximab helps some patients with chronic and otherwise difficult to treat myasthenia gravis.
|Refractory Myasthenia Gravis
|Drug: Rituximab (Rituxan)
|Phase 1 Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Phase 1-2 Pilot Study of Rituximab (Rituxan) in Refractory Myasthenia Gravis.
- To examine the effects of rituximab on disease activity in MG patients with refractory disease. [ Time Frame: Patients will be followed for one year ]
- To determine the safety and tolerability of rituximab in MG patients with refractory disease. [ Time Frame: Patients will be followed for one year ]
|Estimated Enrollment:
|Study Start Date:
|April 2004
|Study Completion Date:
|March 2009
|Primary Completion Date:
|March 2009 (Final data collection date for primary outcome measure)
Drug: Rituximab (Rituxan)
- Rituxan
- Rituximab
- MabThera
|Ages Eligible for Study:
|18 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Criteria for patient selection will be based upon the recent recommendations for clinical research standards by the Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America (Jaretzki et al, 2000).
Patients will be included in the trial based upon fulfilling all the criteria given below, except that they will be required to fulfill criterion 3 OR 4:
- Patients must have a diagnosis of "Definite" MG (Seybold, 1999) as based on clinical, electrophysiological and serological criteria (Appendix 1)
- Patients must have disease predominantly affecting bulbar or respiratory muscles of moderate or severe degree (Osserman grades 2B, 3 without crisis, or 4 without crisis) (Osserman and Genkins, 1971 and Appendix 2) as listed in Appendix 3, and a Quantitative MG score of <25 (Appendix 7)
- Patients must have disease refractory to treatment for at least 12 months with prednisone at a dose of 15mg/day and/or immunosuppressive drugs (azathioprine or cyclophosphamide at a dose of 100mg/day or cyclosporine at a dose to produce trough levels of >50), with or without thymectomy and plasmapheresis/IVIG alone or in combination with above drugs at intervals of no more than once every 3 weeks, OR
- Patients must have experienced intolerance or unacceptable side-effects following treatment with corticosteroids, immunosuppressive drugs (azathioprine, cyclophosphamide or cyclosporine), plasmapheresis or IVIG
- Patients must be between 18 years and 80 years old
Patients must have adequate organ function / laboratory parameters as measured by the following criteria (values should be obtained within 2 weeks prior to enrollment):
- Documented CD20 + cells
- Absolute neutrophil count: >2000/mm3
- Platelets: >100,000/mm3
- Hemoglobin: >10 gm/dL
- Adequate renal function as indicated by normal BUN and creatinine levels
- Adequate liver function, as indicated by AST and ALT <2x Upper Limit of normal.
- Normal serum electrolytes
- Men and women of reproductive potential must agree to use an acceptable method of birth control during treatment and for one year after completion of treatment
- Written informed consent.
Exclusion Criteria:
Patients will be excluded from the trial based on the following criteria:
- Myasthenic crisis with a forced vital capacity (FVC) of <30% predicted, irrespective of need for respiratory support, or severe bulbar involvement (Appendix 3)
- Patients requiring maintenance plasmapheresis or IVIG infusions at intervals of less than once every three weeks
- Patients requiring respiratory support with invasive or non-invasive ventilation
- Severe, uncontrolled or untreated concomitant cardiac (New York Heart Classification III or IV disease), hepatic, pulmonary, renal, hematologic or psychiatric disease
- Toxicity grade 2 or more prior to treatment with rituximab in patients who failed prior treatments
- Patients unwilling to attend for follow-up visits according to the study design
Patients will be excluded based on the following criteria:
- History of HIV disease
- Active Hepatitis B infection
- Pregnancy (a serum pregnancy test will be performed for all women of childbearing potential immediately before treatment)
- Active infection
- Pregnant or breastfeeding women may not participate due to the lack of information on effects of rituximab on the fetus and developing child
- Concomitant malignancies or previous malignancies within the last 5 years, with the exception of adequately treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix.
- No prior monoclonal antibody therapy.
- History of significant psychiatric disease that will interfere with the consenting procedure, research visits, treatment protocol or evaluation of patients in the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00619671
|United States, New York
|State University of New York
|Syracuse, New York, United States, 13210
|United States, Vermont
|University of Vermont Department of Neurology
|Burlington, Vermont, United States, 05405
|Principal Investigator:
|Rup Tandan, MD, FRCP
|University of Vermont Department of Neurology
|Responsible Party:
|Dr. Rup Tandan, M.D., F.R.C.P., Professor, University of Vermont
|ClinicalTrials.gov Identifier:
|NCT00619671 History of Changes
|Other Study ID Numbers:
Genentech #U2444S
|Study First Received:
|January 14, 2008
|Last Updated:
|January 15, 2013
Keywords provided by Dr. Rup Tandan, M.D., F.R.C.P., University of Vermont:
Myasthenia Gravis
Additional relevant MeSH terms:
Myasthenia Gravis
Muscle Weakness
Muscular Diseases
Musculoskeletal Diseases
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Pathologic Processes
Signs and Symptoms
Autoimmune Diseases of the Nervous System
Neuromuscular Junction Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases
Antineoplastic Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
ClinicalTrials.gov processed this record on September 21, 2017


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To commemorate Veterans Day today, the newly-formed Oglethorpe Veterans Club distributed yellow lapel ribbons to raise awareness, held a campus-wide moment of silence at 11 a.m. to remember those who have fallen, and hosted a "Lest We Forget" brunch event to honor those who've served and their families.
The Oglethorpe Veterans Club members include veterans, family members, students, faculty, staff and alumni who have come together to recognize the contributions of soldiers.
"Veterans are really everywhere," said Jef Palframan '13, founding president of the OU Veterans Club—and a veteran himself. "The club is for everyone, not just veterans, and our mission is the aid those who have served and their families."
The event opened and closed with prayers for those who have fallen in battle, for those who are missing, and those who are fighting right now. There also were toasts made to those who have served and their families, as well as remarks from Dean of Students Michelle Hall, OU Trustee Fred Agel '52, and Trustee Emeritus O.K. Sheffield '53. Veterans who attended were encouraged to wear their uniforms and medals.
OU shares a long history with alumni veterans and veterans-turned-students. Oglethorpe's first international students in the 1940s were four Norwegian veterans of WWII. (Read the full article: Summer 2011 Carillon, pages 10-11.) Currently there are 13 veterans enrolled as students at Oglethorpe.


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This isn't the most photogenic soup I've made, but it was delicious, warm, and comforting. I added a touch of red pepper flakes to spice it up a little, but you could skip that if you'd like a milder soup. Please don't skip the ground fennel seed though; it adds a wonderful flavor to the soup.
Spicy Yellow Split Pea Soup with Italian Sausage and Green Pepper
(Makes 6-8 servings, recipe created by Kalyn.)
1 T + 1 T olive oil
1 medium yellow onion, finely diced
1 cup finely diced celery
1 green bell pepper, finely diced
1 T minced garlic (or less if you're not that into garlic)
1 tsp. Italian herb blend (a mix of dried oregano, basil, thyme, marjoram, and rosemary)
1/2 tsp. ground fennel seed
1/4 tsp. red pepper flakes (optional)
1 pkg. (5 links / 19.5 oz.) hot turkey Italian sausage
2 cups yellow split peas
6 cups chicken stock (plus more water as needed during cooking)
salt and fresh ground black pepper to taste
Serve with Parmesan cheese and red pepper flakes for people to add to the soup if desired.
Low-Carb Diet / Low-Glycemic Diet / South Beach Diet Suggestions:
Crockpot Split Pea Soup ~ Eats Well with Others
Split Pea Soup with Ham, Bay Leaves, Epazote, and Red Bell Pepper from Kalyn's Kitchen
Vegan Split Pea Soup with Challah Croutons from The Perfect Pantry
Instant Pot Split Pea Soup with Ham and Sweet Potatoes from Kalyn's Kitchen
Chana Dal and Yellow Pepper Soup with Lemon Cream from The View from Big Island


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What this? I'm not able to pronounce it. Well did not find a female text to speech synthesizer, but since Len is actually a guy anyway, everyone can check there out what sounds she did there http://www.syvum.com/text_to_speech/LennyeTran wrote:Hardi wrote:It's also not Asia.
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One of our readers recently asked about Vanguard's view on 401(k) loans.
As you might know if you've poked around Vanguard.com, we generally frown upon retirement plan loans, to put it mildly. In fact, Vanguard's intranet for employees recently featured an article cautioning us against borrowing from our own retirement accounts.
Titled "He [or she] that goes a borrowing goes a sorrowing," the article noted that Benjamin Franklin's favored method for making difficult decisions was to put together "a side-by-side list of the reasons for and the reasons against a certain course of action." To help out, the article offered a list of "negative consequences of taking a loan." It may have been a bit over the top, but I basically agree that retirement plan loans can be misused. There is always a cost to borrowing, and with plan loans there are some risks.
You shouldn't borrow from your retirement plan—or from anywhere else, in general—unless you really have to, in order to pay for something that is a necessity. In this category I'd include a house, a higher education, and perhaps a (first) automobile. I'd also include large unexpected medical bills, or the money required to deal with a true family emergency. But I think you have to think twice about borrowing anywhere (banks, credit cards, or your retirement savings) to fund things that you don't absolutely need. In my view, an overeagerness to borrow on the part of consumers was a major driver in the financial crisis we're now going through.
But now to the neglected potential benefits of a 401(k) loan.
If you're in a position in which you need a loan for a real necessity, then it's totally appropriate to consider borrowing from your 401(k). The essential advantage of a plan loan is that instead of paying interest to a third party, you pay it to yourself, so the cost of the loan is whatever administrative fees you pay plus any lost return on the assets that you've borrowed. In most circumstances—particularly if you don't have stellar credit—this means 401(k) loans have lower total costs than the alternatives.
(Another cost: The interest you owe on your plan loan is paid back to your account with after-tax dollars, and when you withdraw it in retirement, you'll pay tax again. But this is a very minor cost, and it's not true, as is sometimes claimed, that the entire loan amount is "taxed twice"—just the interest payments.)
There are some additional risks to a plan loan. A big one is that you could wind up leaving your employer before you repay the loan. In a 401(k) plan, if this happens, you must immediately pay back the loan, or it will be considered a taxable distribution—in which case you'll owe taxes on the loan proceeds, plus any applicable tax penalties if it's an early distribution (i.e., if you are younger than 59½). This can make a cash-crunch situation even worse, so you need to be very sure you're going to stay at your employer long enough to repay the loan.
In addition, some borrowers defer new contributions into their 401(k) plans while they repay their loans. This is a permanent loss of an opportunity to save on taxes on your retirement assets, and can be a significant disadvantage later. But if you have to stop contributing to your 401(k) in order to repay a plan loan, presumably you'd also have to stop contributing to make payments on an alternative loan outside the plan. This isn't a reason to choose an alternative loan over a 401(k) loan—it's just another reason not to borrow at all in the first place.
Vanguard.com has a neat plan loan calculator that will show you the estimated cost of a plan loan (as well as the cost of an alternative loan). The tool emphasizes the cost of the loan in terms of the investment returns you'd potentially give up. It's very useful information, but you do need to be careful in interpreting it. The rate of return you assume on your plan assets should line up with what you think you'd receive if you took little or no investment risk (think money market account).
It's simply not true that giving up stocks in your retirement plan in exchange for a loan will result in a certain loss in the future value of your plan. Ask anyone who borrowed against the stock portion of their plan assets in early 2008. They're likely to be quite happy that, thanks to the loan, their plan balance won't fully reflect recent stock market losses. This is just the flip side of a more obvious fact: Borrowing outside the plan at a fixed rate in order to invest in stocks inside the plan does not produce a certain profit. Doing the reverse doesn't create a certain loss, either. So, use a money market rate in estimating the "return give up" cost of the loan.
With a money market rate of interest as a baseline, you'll generally see that a plan loan can make very good financial sense if you are in extreme circumstances and absolutely have to borrow. But if you aren't in such a situation, remember there are always significant costs to borrowing, no matter what the source. Paying cash up-front is generally always the cheapest way to obtain the things you want in life. Don't treat your retirement plan as a slush fund!
• All investments are subject to risk.
• When taking withdrawals from an IRA before age 59½, you may have to pay ordinary income tax plus a 10% federal penalty tax.


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They go at Beverley, Yarmouth, Haydock, Clonmel, Hamilton and Kempton on Wednesday. Compare odds and bet at the best prices.
Horse Racing Quick Links:
Horse Racing Money Back Specials
Free bets, betting, odds comparison, racing results, football scores at Betrescue
Helping you to win against all the odds
They go at Beverley, Yarmouth, Haydock, Clonmel, Hamilton and Kempton on Wednesday. Compare odds and bet at the best prices.
Horse Racing Quick Links:
Horse Racing Money Back Specials
Open new betting accounts and claim over £3500 in free bets from over thirty of our bookmaker partners. Free bets directory
We have compiled a number of football moneyback specials from our partner bookmakers including all the big TV action. View offers
Chris Hutcheon pinpoints the weekend money making opportunities this weekend in the new Premier League season. Live scores | Compare odds | Preview...
We have compiled a number of horse racing cashback offers from our partner bookmakers open to new and existing customers. View offers
In today's newspapers, the most tipped horse is Snax (13/8) in the Newcastle 18:45 (tipped 9 times). Check out all today's naps.
Former Talksport man Charlie McCann marks your card with eight to follow on Friday at Newbury, Ayr and Newton Abbot. Preview
Paul Ferguson has one selection for us on Friday; Minotaur in the Newbury 14:55. Compare odds and bet.
Alex Hammond's Tip of the Day: Sky Sports' Alex goes for 9/2 shot Iniesta in the 16:10 at Newton Abbot. Skybet Bet £5 Get £20 Free
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At Betrescue.com we keep you up-to-date with all the breaking betting news stories from the sporting world, tell you where to find the best betting odds and help you to get the best value for money.
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Betrescue supports responsible gambling. For more information visit GamCare and Gamble Aware.


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Angels release Japan league veteran Kobayashi
PHOENIX -- The Angels released veteran pitcher Hiroyuki Kobayashi on Monday, giving the right-hander a chance to land with another team. Kobayashi, 34, went 26-36 with a 3.65 ERA in five seasons split between Japan's Pacific and Central leagues, but this was his first attempt at landing a job in the Major Leagues.
Most of Kobayashi's career came with Chiba Lotte, where he was managed by Bobby Valentine for three seasons. Kobayashi's most effective season came in 2007, when he went 13-3 with a 2.69 ERA for Chiba Lotte, and he registered a 2.21 ERA as a reliever for the same team in 2010.
Kobayashi, who pitched last year in Japan's Industrial League, registered a 4.50 ERA in three appearances for Los Angeles this spring, and manager Mike Scioscia said the release was best for all parties.
"Kobi just wasn't as far along as he needed to be to compete for a job on our staff," Scioscia said after his team's 13-5 loss to Oakland. "It's probably better if he's wants to go somewhere else and hook on."


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V - Code of Student Conduct
Definitions | Prohibited Conduct | Table of Contents
- University: Clarkson University at Potsdam, New York.
- Academic Community: all members of the faculty, administration, staff, and student body.
- Student: an individual who is enrolled (full or part time) in courses offered by the University.
- University Premises: buildings and grounds owned, leased, and used by the University.
- University-sponsored Activity: any activity on or off campus which is initiated, organized, controlled and supervised by the University.
- Organization: a number of people belonging to a recognized University group.
The University expects that all students will conduct themselves as responsible members of society as defined by this Code. Disciplinary measures will be taken for the following reasons. Note, however, these do not cover every single circumstance when disciplinary measures will be enacted. In general, any act that infringes upon the rights of others or that adversely affects the academic or administrative activities of the University is prohibited.
- Violations of any federal, state, or local law, where, in the judgment of the University, the person charged endangers the property or threatens the personal safety of the academic community.
- Violations of University policies and regulations as stated in this booklet and any other regulations that may be enacted.
- Fraudulent or dishonest conduct, including but not limited to, providing false information to the University.
- Failure to comply with instructions of administrative officials, including resident advisers, who have duly identified themselves.
- All forms of academic dishonesty, including cheating, fabrication, plagiarism, and aiding and abetting of a dishonest act. (A violation pertaining to this item will be handled through the Academic Integrity procedures.)
- Intentional disruption or obstruction of teaching, research and administrative activities or any other form of infringement upon the rights or freedoms of a member of the academic community.
- Theft from or damage to the University, University-affiliated services, members of the academic community, or visitors to campus, as well as damage to their property.
- Abuse, verbal or physical, or threat of same upon any member of the academic community.
- Any behavior that is socially or morally unacceptable.
- Unauthorized use, possession or storage of any weapon, explosive device or material, including but not limited to firearms, knives, fireworks or ammunition.
- Possession, use or distribution of a controlled substance or illegal drug or paraphernalia related to its use.
- Tampering with fire-warning devices, protection equipment and other related devices designed to protect the safety of the academic community.
- Repeated offenses which, by themselves, would not warrant suspension or dismissal, but collectively indicate that further attendance by the student is not in the best interests of the student or the University.


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The real estate market in Dubai will stage a strong rebound in 2017 and experience a higher growth rate by 2020 due to effective measures taken by the regulators in recent past, says an industry expert. Pawan...
Cityscape Global, showcasing some of the most spectacular real estate developments from across the region, kicked off on Tuesday with a spate of project unveilings and announcements by major developers amid brightening prospects forecast for the property industry...
The 15th edition of Cityscape Global is expected to attract a new wave of real estate investors from across the region, following the success of recent exhibitions in Turkey, Egypt, Abu Dhabi and Qatar. So far in...
Welcoming almost 1,000 more attendees to the Abu Dhabi National Exhibition Centre this year, the global presence was felt on the show floor, with the number of international exhibitors increasing significantly. The real estate sector in the Middle East looks to...
Middle East investment into commercial real estate (CRE) rises in line with oil prices, as more surplus funds become available, according to Savills plc, a global real estate services provider listed on the London Stock Exchange. However, the firm has also...
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ROMULUS, Mich. - Flights in and out of Detroit Metro Airport are back to normal after two consecutive days of cancellations or delays.
High winds in Metro Detroit and snowy conditions around the country caused the travel problems. Some travelers at the airport scrambled to make new arrangements, renting cars or riding buses to their destinations.
Weather: Metro Detroit roads slippery, dangerous with icy, snowy conditions
Nearly 50 flights to and from the airport were cancelled Friday. Eighty-seven flights were delayed for more than 45 minutes.
Still, Friday was a smoother day than Thursday. The airlines cancelled flights earlier, and alerted travelers before they came to the airport.
Airport officials remind drivers picking up loved ones to park in cellphone waiting lots. That helps reduce congestion outside the terminal.
People are also urged to call or go online for information about the status of flights and TSA security rules. They also should avoid bringing wrapped gifts.
Copyright 2012 by ClickOnDetroit.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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From the Kardashians to the Hiltons—here's a who's who list of the most stylish sisters.
Watch: Maria Menounos Reveals Her Fashion Secret
News: Get Rachel McAdam's Cool Bun from the To the Wonder Screening!
Photos: Debby Ryan, Michelle Williams, and Other Celebs Celebrating the Kate Young Target Line
Who do you think the best-dressed sibs are? Sound off in the comments or on Twitter @OKMagazine!


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Category: Isis
We're all familiar with the ancient Greek and Roman pantheons of mythological deities, from Adonis and Athena to Zeus, but there a number of other ancient names from other cultures with their own pantheons of intriguing god and goddesses. We've delved into the some of the most intriguing mythologies—Egyptian, Phoenician, Norse, Celtic, Indian, African, et al– and discovered some striking ancient names for the intrepid baby namer.
ÁINE (AWN-ya)– Irish Celtic goddess of love, summer, wealth and fertility
AINO (EYE-no) — A Finnish mythological water sprite
ALA—African (Nigerian) creator goddess and earth mother


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A PROMISING young soldier was accidentally shot dead when his colleagues removed the barrel from a machine gun as it pointed directly at him, a court martial heard.
Fusilier James Wilkinson, aged 21, from the 2nd Battalion of the Royal Regiment of Fusiliers (2RRF), was killed by the negligence of his own men on a live firing exercise in Kenya, it is alleged.
His section commander, Corporal Colin Bell, had removed the barrel from a machine gun to inspect a stoppage when it fired off a round, shooting Fusilier Wilkinson in the neck.
The soldier, who had been living in the Spring Lane area of Radcliffe with his wife Sarah, was killed by the unintentional discharge on the firing range.
A full military funeral was held at St Thomas and St John's Church in Radcliffe, just five months after his wedding to Sarah had been held there.
She was seven months' pregnant with the couple's first child at the time of his death and has since given birth to a healthy daughter.
Fusilier Wilkinson and a colleague were manning a general purpose machine gun in the mock battle for more than 100 troops in scorching hot terrain, Bulford military court centre, in Wiltshire, was told on Monday.
To their right, Fusilier Aaron Davenport, a gunner, and Fusilier Renaldo Nelson, a controller, also from 2RRF, were operating another, watched by their safety supervisor Cpl Bell.
This gun jammed and would not fire — known in military terms as a "hard cock" and makes it impossible to check if the firearm is unloaded.
But instead of following safety procedure and calling in an armourer to fix it, Cpl Bell got Davenport and Nelson to remove the weapon from its position and took it apart himself.
He placed the gun on the ground, pointing directly at the gun team, and removed the barrel.
Troops were alerted to Wilkinson, hailed as an exceptionally fit soldier with "long term potential" by the Ministry of Defence (MOD), being down by someone shouting "Stop! Stop! Stop!", it was heard.
Now three of his comrades — Davenport, Nelson and Staff Sergeant Patrick Price, from the Scots Dragoon Guards — are on trial for negligently performing a duty. They have pleaded not guilty.
Prosecutor Lieutenant Colonel Callum Cowx said the "tragic case" raised issues of "basic principles" and "common sense".
Mr Cowx told the five-man jury: "Each of these men failed to do what they were required to do and they each in their own way led to the tragic outcome.
"The Crown's case is about basic principles about basic common sense which we say are commonly understood by anyone wearing this Army uniform.
"It is about basic duties expected of a safety supervisor on live firing exercises.
"James Wilkinson had the expectation that they would carry out their responsibilities and look after his safety.
"They failed to do so, they were negligent of their duty and as a consequence of their collective action, James Wilkinson died."
Mrs Wilkinson wept in court as she heard details of her husband's fatal incident on November 26, 2011.
Fusilier Wilkinson, a Manchester United fan, had moved to Whitefield with his parents, Jan and Rob, in 2008.
He joined the Army in May 2011 and trained at Catterick, North Yorkshire, before being deployed to Kenya on his first battalion level exercise, Ex Askari Thunder.
The trial continues.


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DENVER (AP) -- The Colorado movie theater complex that was the scene of a gunman's massacre didn't have any uniformed security guards on duty the night of the shooting, even though other theaters operated by the same company did provide such protection for the busy opening night of the Batman film "The Dark Knight Rises."
It's impossible to know whether guards -- often off-duty police officers -- at the Aurora Century 16 would have spotted the suspected gunman, James Holmes, and thwarted the attack that left 12 moviegoers dead and dozens wounded on July 20. Cinemark provided off-duty police guards at the Aurora theater on busy Friday and Saturday nights.
As for other nights, theater operators decide on a case-by-case basis whether to hire security, depending on the likelihood of trouble.


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Expedia Tumbles 17%: Q2 Rev, EPS Miss; Hotel Revenue Affected by Mix
Shares of online travel giant Expedia (EXPE) are down $15.11, or 23%, at $59.89, after the company this afternoon reported Q2 revenue and earnings per share that missed analysts' estimates.
Revenue in the three months ended in June rose 16%, year over year, to $1.21 billion, yielding EPS of 64 cents.
Analysts had been modeling $1.26 billion and 81 cents.
Room nights in the quarter rose by 19%, a slowing from the prior-year period's 22% growth rate.
Gross bookings rose 13% to $10.12 billion. The company's Ebitda, on an adjusted basis, fell 14%, to $191.7 million.
Room rates and average airfare prices were flat with the prior-year period, the company said. Air tickets sold rose by 7%, helped by results in the company's Egencia unit, with domestic ticket sales up 7% and international ticket sales up 23%.
Despite the steady rates, average revenue per room night fell 6%, the company said, which it attributed to "changes in our hotel product mix, of which mix shift to Asia-Pacific remains a significant component."
CEO Dara Khosrowshahi remarked "We knew we were facing second quarter headwinds and those which we expected, as well as some we didn't, materialized."
"Despite this, we remain confident about our long-term strategy. We see continued return on our core brands' technology investments, broader adoption of Expedia Traveler Preference Program, momentum in our recent acquisitions and emerging markets as well as exciting traction in one of travel's fastest growth channels."
Shares of competitor Priceline (PCLN) are down $16.90, or 1.9%, at $895.10 in late trading. Competitor Orbitz Worldwide (OWW) is unchanged at $9.99 in the after-market.
Expedia is hosting a conference call with analysts at 4:30 pm, Eastern time, and you can catch the webcast of it on the company's investor relations Web site.


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Quick installation and removal
More inlets are easily added
Mesh filter is easy to clean
Gasket seals against overflow
Provides reliable performance, larger capacity, and simpler installation and maintenance. Sump box features include an air vent to prevent air locks. Slotted mounting feet allow for quick installation and removal. Straight mesh filter allows for easy removal and cleaning. Inlets are routed directly into the sump box instead of through a shared manifold so additional inlets can be added to the left, right, and back side of the sump box through the use of thru-hulls. Water is pumped out with Attwood's Sahara pump with self-contained float switch. Lid easily snaps on and off and includes a gasket to seal the sump box against overflow. 36" wire. 3-amp fuse. 1.4 amp draw. 3/4" ID hose size. Measures 10-1/2" x 8-1/8" x 4-1/2".


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|Product Description
Recirculating Torlon® ball bearings allow CB (captive ball bearing) genoa lead cars to adjust easily under full sheet loads. Sheaves feature high-load axle bearings for easy trimming. The wide sheaves accommodate two sheets during sail changes. Sheave carriers pivot to adapt to changing lead angles.
All CB genoa lead cars are offered with end controls.
Part Number: G274B


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Moderator: Mahavihara moderator
Sekha wrote:Modern scholars suggest that Pali was probably never spoken by the Buddha himself.In the centuries after the Buddha's death, as Buddhism spread across India into regions that spoke different dialects, Buddhist monks increasingly depended on a common tongue for their discussions of Dhamma and their recitations of memorized texts. It was out of this necessity that the language we now know as Pali emerged.
http://www.peacehall.com/news/gb/englis ... 0400.shtml
Dmytro wrote:For more details about the Hathigumpha inscription see:
http://gujaratisbs.webs.com/Abstracts%2 ... 20More.pdf
Dmytro wrote:Evidently the evolution of Magadhi as a state-supported lingua franca went through the following stages:
1 - Magadhi of Buddha's lifetime, preserved in the Pali texts - Haryanka dynasty;
2 - language of the Shishunaga and Nanda dynasties - not preserved;
3 - Magadhi of Asoka's edicts - Maurya dynasty;
4 - language of inscriptions from the dissolution of Maurya empire until the sanskritization - Satavahana and Mahameghavana dynasties. The latest of these inscriptions are dated by 3rd-4th centuries CE.
Qianxi wrote:What is it that links Pali to stage 1 rather than just to stage 4?
The final extract from Salomon seems to associate Pali with the rise of western dialects after the fall of the Mauryan empire. The first summary you post suggests that the Buddha would have spoken Ardha-Magadhi for preaching, which I suppose would be an eastern dialect.
I wonder if we would expect the language of orally recited scripture to change as the language develops, or to preserve archaic forms.
How does Gandhari fit into this picture? Presumably the Gandhari texts we have come from period 4, during the use of Western Pali-like dialect as lingua franca. Gandhari is also part of that western dialect group I suppose?
Wilhelm Geiger wrote:The conclusion has been drawn -- wrongly, in my opinion, -- from Culavagga V.33.1 = Vin II.139. Here it is related, how two Bhikkhus complained to the master that the members of the order were of various origins, and that they distorted the words of Buddha by their own dialect (sakaaya niruttiyaa). They therefore proposed that the words of Buddha should be translated into Sanskrit verses (chandaso). Buddha however refused to grant the request and added: anujaanaami bhikkhave sakaaya niruttiyaa buddhavacanam pariyaapu.nitum. Rhys-Davids and Oldenberg translate this passage by 'I allow you, oh brethren, to learn the words of the Buddha each in his own dialect.' This interpretation however is not in harmony with that of Buddhaghosa, according to whom it has to be translated by "I ordain the words of Buddha to be learnt in _his_ own language (i.e.Magadhi, the language used by Buddha himself)." After repeated examination of this passage I have come to the conclusion that we have to stick to the explanation given by Buddhaghosa. Neither the two monks or the Buddha himself could have thought of preaching in different cases in different dialects. Here the question is merely whether the words of Buddha migth be translated into Sanskrit or not. This is however clearly forbidden by the Master, at first negatively and then positively by the injunction beginning with 'anujaanaami'. The real meaning of this injunction is, as is also best in consonance with Indian spirit, that there can be no other form of the words of Buddha than in which the Master himself had preached.
In the Haimavata Vinaya mātikā
There were two Brahman Bhikkhus, named Usaha and Samadha, who went to the Buddha and said to him, "The disciples of the Buddha come from different castes of different places in different countries. Their language is not the same and their pronunciation is incorrect, and thus they distorted the right teachings of the Buddha. May the Blessed One allow us to carry out debates and compile the scriptures according to the Chandas way, so that the sentences may be arranged in order and the pronunciations corrected, in order to unveil the teachings of the Buddha." The Buddha told the Bhikkhus, saying, "In my teachings emphasis is not laid on rhetoric. What I mean is that the doctrines should not be misunderstood. They should be taught in any language which is understood by the people, according to their suitability." Therefore, his teachings were taught according to the circumstances of the land.
In the Dharmagupta-vinaya, Vol. LII:
There was a Bhikkhu named Bravery, who was the descendant of a Brahman family. He came to the presence of the Buddha, and after having worshipped him, he sat aside and said to the Blessed One, "Venerable Sir, the Bhikkhus come from different castes and have different names. They misinterpreted the teachings of the Buddha. May the Blessed One permit us to rearrange the Buddhist scriptures in Sanskrit." The Buddha said, "You are fools! That would be a defacement to mix the Buddhist scriptures with a heretical language." He further said, "Recite the scriptures in the language of the country according to the custom of the people."
In the Mahisasaka-vinaya, Vol. XXVI:
There were two Brahman brothers who were versed in the Chandas-veda and later became monks in the Buddhist Order. They heard that the Bhikkhus were reciting the scriptures in an improper way, and said to them scornfully, "You venerable sirs have become monks for a long time, and yet you don't know the masculine and feminine genders, the singular and plural numbers, the present, past and futrue tenses, the long and short vowels, and the heavy and light acents. In such a way you are reciting the scriptures!" The Bhikkhus were ashamed to hear this remark, and the brothers went to the Buddha and reported the case to him. The Buddha said, "They are allowed to recite the scriptures in their own native tongue, only that they should not misunderstand the Buddha's meaning. No one is allowed to mix the Buddha's word with a heretical language. One who acted contrarily would be considered as having committed the offence sthulatyaya."
In the Sarvāstivāda-vinaya, Vol. XXXVIII:
Once the Buddha was in Sravasti. There were two Brahmans, one being names Gopa and the other one, Yapa, who had a devout faith in Buddhism and become Buddhist monks. They had formerly learned the heretical four Vedas, and after having become monks they recited the Buddhist scriptures with Vedic intonations. Then one of them died, and the one who was alive forgot some passages of the scriptures and could not recite them fluently. He could not find a companion and was unhappy of it. Thus he told it to the Buddha, who said to the monks, "From now onwards anyone who recites the Buddhist scriptures with a heretical intonation will be considered as having committed the offence of Dukkata."
In the Mūlasarvāstivāda-nikāya-vinaya-samyuktavastu, Vol VI:
Once the Buddha was in Sravasti. At that time the Ven. Sāriputra ordained two Brahmans into the Order. One of them was called Ox-given and the other one, Ox-born. Both of them studied the recitation of Buddhist scriptures. Afterwards they travelled about and came to a village, where they obtained many offerings and took up their lodgings there. Now these two persons had formerly learned the pronunciation method of Brahmanic hymns. So when they recited the Buddhist scriptures, they habitually followed their old method. Then one of them suddenly died of illness. The one who was living was grieved by the death of his friend, and forgot most of the scriptures through negligence. Thus he returned to Srāvasti and came to the Jetavana Grove. After having taken rest, he went to see the Ven. Kaundinya, to whom he paid his respect and said, "Venerable Sir, let us review the scriptures together." "Very well, I shall recite them for you," was the reply. After the elder had recited some passages of the scriptures, the monk said to him, "Venerable Sir, your recitation of the scriptures is mistaken. The vowels are not pronounced as long ones, and so there is something missing." The elder said in reply, "I have always recited the scriptures in this way." Thus the monk took his leave and went to see Asvajit, Bhadra, Mahānāma, Vasas, Yaśas, Pārna, Gavāmpati, Vimala, Subāhu and Rāhula, to each of whom he said, "Venerable Sir, let us review the scriptures together." "Very well, I shall recite the scriptures for you," was the reply. After the elder had recited some passages, etc. etc., the monk took his leave and went to see the Ven. Sāriputra, to whom he paid his respect and said, "Upādhyāya, let us review the scriptures together." While they were reciting the scriptures together the monk elongated the vowels, and Sāriputra pronounced them with double length. The monk said, "Venerable teacher, all the other elders are mistaken in their recitation. Only you, Venerable teacher, are correct in pronunciation and grammar." Sāriputra said to him, "You are a fool. You are mistaken yourself, and yet you slander those wise men, saying that they do not know how to recite the scriptures. None of the elders is mistaken in the recitation." Having been rebuked, the monk remained silent. Then the monks reported this to the Buddha, who thought in his mind, "All this trouble is caused by the elongation of vowels in the way of singing hymns when the monks recite the scriptures. Therefore the monks should not elongate the vowels in the way of singing hymns when they recite the scriptures. Any monk who recites the scriptures in the Chandas way shall be considered as committing a transgression. But one is not considered so, if the vowels are elongated according to his own dialect."
What was Magadha/Magadhi at the time of the Buddha?
What was Magadha/Magadhi at the time of Asoka?
What did the Sri Lankans regard as Magadha/Magadhi at the time of the arrival of the Pali texts in Sri Lanka?
What was Magadha/Magadhi at the time of the commentaries?
What was Magadha/Magadhi at the time of the literary Prakrits?
arhat wrote:The -dha suffix of the name Magadha seems to be unstable and was sometimes dropped, and the m was sometimes pronounced as a v (both being labial consonants and interchangeable) or dropped altogether - thus giving us three names of the same country - Magadha, Vanga & Anga (the medial nasal also seems to be unstable).
Dmytro wrote:arhat wrote:The -dha suffix of the name Magadha seems to be unstable and was sometimes dropped, and the m was sometimes pronounced as a v (both being labial consonants and interchangeable) or dropped altogether - thus giving us three names of the same country - Magadha, Vanga & Anga (the medial nasal also seems to be unstable).
That's untrue. See:
Kare wrote:To me it is baffling to see that none of the respected scholars quoted here seem to be aware of the problem of Magadha/Magadhi.
Dmytro wrote:Hello Kare,Kare wrote:To me it is baffling to see that none of the respected scholars quoted here seem to be aware of the problem of Magadha/Magadhi.
Are you familar with a a book:
Greater Magadha: Studies in the Culture of Early India, by Johannes Bronkhorst
manjughosamani wrote:Hi Kare,
You can read the majority, if not all, of the text online here: http://www.scribd.com/doc/207362992/Bronkhorst-J-Greater-Magadha-Studies-in-the-Culture-of-Early-India
All the best.
Dmytro wrote:Lance Cousins writes:
"The standard epigraphical language used in the Gangetic plain and beyond in the last centuries B.C. and a little after was a form of Middle Indian rather close to Pali. We have no reason to believe that any other written language existed in that area at that time. Like Pali it is eclectic with word-forms originally from different dialectics and also with no standardized spelling (as was probably originally the case for Pali). So the first Buddhist texts written down in that area should have been in that form. Since the enlarged kingdom of Magadha eventually extended over nearly the whole Gangetic plain, that language was probably called the language of Magadha, if it had a name. And that of course is the correct name of the Pali language.
Pali is essentially a standardized and slightly Sanskritized version of that language. Māgadhī is a language described by the Prakrit grammarians and refers to a written dialect that developed later (early centuries A.D. ?) from the spoken dialect in some part of 'Greater Magadha'.
In effect, then, Pali is the closest we can get to the language spoken by the Buddha. And it cannot have been very different — we are talking about dialect diferences here, not radically distinct languages."
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Financial Reporting Obligations | Rights
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Fair operation of the financial aid program requires that students, parents and spouses provide all information requested by the Financial Aid Office as fully and as accurately as possible. It also requires that they notify the Financial Aid Office promptly, and in writing, of any significant changes in their financial circumstances during the year.
Students (and spouses) must report any increase of more than $200 in net income (or aggregate net income) after taxes and business deductions, or a reduction of more than $200 in living expenses (or aggregate living expenses) due to payment in kind for services rendered, or receipt of aid from outside sources.
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Prospective recipients of student financial aid have the right to receive an accurate description of the following:
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Automate professional design
Adobe InDesign CS5.5 Server software powers automated solutions that enable publishers to go beyond manual processes and create new content and revenue streams. Easy to integrate with standard development environments, it provides a robust, flexible, and scalable engine for professional page composition.
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This product is shipped only within Canada and Warranty valid for Canada only.
Computer Valley makes every effort to provide accurate specifications, descriptions, images and price on all products that are found on www.computervalley.ca
However for complete and updated descriptions, compatibilities, specifications and actual photo we recommend our clients to consult with manufacturer's websites or simply call us for proper clarifications. Computer Valley is not responsible and will not accept returns for items purchased that are not compatible with your system. Please ensure that you have verified compatibility and actual photo with your system by visiting the manufacturer's web site prior to purchase or give us a call to make sure what you are purchasing.
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- AM FM Radios
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Prices shown in currencies other than US Dollars are estimates based on current exchange rates. We will charge your credit card in US Dollars on the day your order is shipped, and the conversion to your local currency will be done at the prevailing rate by your credit card issuer.
C. Crane will not mark your parcel as a "gift", declare a value lower than the actual price paid, or otherwise prepare false customs information.
You may have noticed this new acronym popping up on some of our products. RoHS stands for Restrictions on Hazardous Substances, and it's a directive that could have a huge impact on the production and disposal of consumer electronics. First adopted in Europe in 2006 (and later adopted in California in 2007), RoHS restricts the use of six dangerous substances in lots of common electronics. According to the official RoHS compliance Web site (www.rohs.eu), the RoHS symbol indicates that "new electrical and electronic equipment put on the market does not contain any of the six banned substances: lead, mercury, cadmium, hexavalent chromium, poly-brominated biphenyls (PBB) or polybrominated diphenyl ethers (PBDE), in quantities exceeding maximum concentration values."
While some military and medical equipment is exempt from RoHS compliance, the electronics governed by the standard are among the most common you'll find in your home, from radios to MP3 players to cell phones and (increasingly) computers. In practical terms, the standard protects factory workers at the production level, sharply reducing their exposure to hazardous substances. The standard also has a profound impact on the disposal and recycling of electronics, in that disposed substances will no longer have at least six of the most hazardous chemicals formerly found in electronics, and recycled electronics will not expose workers to toxics as they harvest components.
Radio on the Road: The Traveler's Companion by William Hutchings lists just about every AM and FM station in the U.S. Over 15,000 listings are arranged by state, then by city, call letters, frequency, and format. Lists top talk show hosts with stations and times for each state. Home team stations are listed for baseball and football. Also includes a complete listing of NPR stations by location. Excellent for travel. 283 pages.
Now for the rest of the story (by Bob Crane):
There will be times in perpetuity when a computer doesn't cut the mustard. I still read the Wall Street Journal in paper format. It is just plain easier to grab a book when you want to know the frequency or city of a radio station. And with a pencil you can add a note! Try that Mr. Computer - Ha!
We carried White's Radio Log and felt an empty spot when they stopped issuing new releases. When I heard Bill Hutchings was ready to publish his first edition I called and was happy to get set up as a dealer and we've carried Radio on the Road ever since. He has recently sold the rights, but Bill still helps the new publisher get the data ready. With a website like Radio-Locator.com you really don't need Bill's book but he knows that. That's why he focused the content on travel and gives you a good idea of where your favorite shows are. You also get the bonus of a concise information center about radio stations that are on air in your area which is awkward on a computer.
|Lists Stations & Local Air Times For Top Talk Shows
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DreamGear DGWII-1246 Charging Power BaseItem#: D800-1220 | Model#: DGWII-1246
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DreamGear 4 Way Wii Charging Power Base Product Details
DreamGear DGWII-1246 Charging Power Base
The DreamGear DGWII-1246 Charging Power Base charges up to 4 Wii Remotes simultaneously, with or without Wii MotionPLUS, in or out of the Wii Remote Jacket or can charge the Rechargeable Battery Packs by themselves. The DreamGear DGWII-1246 Charging Power Base features LEDs that indicate the Wii Remotes charging status. It is powered by the included 110/240V AC Adapter, so you are no longer limited to charging near the Wii console.
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Prostate Biopsy
(Transrectal Biopsy; Transurethral Biopsy; Transperineal Biopsy)
A prostate biopsy is the removal of a small amount of tissue from the prostate gland. The tissue is examined to determine whether there is cancer.
|Prostate Cancer
|Copyright © Nucleus Medical Media, Inc.
Reasons for Procedure
A prostate biopsy is usually done after an abnormal finding by:
- Digital rectal exam
- Prostate specific antigen (PSA) blood test
A prostate biopsy is the only way to find out if cancer cells are present.
Possible Complications
Problems from the procedure may occur, but all procedures have some risk. Your doctor will review potential problems, like:
- Infection
- Bruising or lengthy bleeding from the rectum, or in urine or semen
- Difficulty urinating
- Reactions to anesthesia
Factors that may increase the risk of complications include:
- Smoking
- History of bleeding disorders or easy bruising
- Use of any medications, over-the-counter medications, or herbal supplements
- Sensitivity or allergy to latex, medications, or anesthesia
What to Expect
Prior to Procedure
You may be asked to do the following:
- Talk to your doctor about your medications. You may be asked to stop taking some medications up to one week before the procedure.
- Begin taking an antibiotic.
- Use an enema several hours before the procedure.
- If you will be getting general anesthesia, do not eat or drink anything after midnight.
The type of anesthesia depends on the method that your doctor uses:
Transurethral biopsy and perineal biopsy:
- General anesthesia—Blocks pain and keeps you asleep through the surgery. This will be used for a transrectal prostate biopsy.
- Local anesthesia—Just the area that is being operated on is numbed, given as an injection and may also be given with a sedative.
Description of the Procedure
Your doctor will use one of the following methods to do the biopsy:
- Transrectal biopsy (most common method)—Your doctor will insert a small ultrasound device into the rectum. This device will produce sound waves to create an image of the prostate. These images will help guide placement of the needle. Your doctor will then insert the needle through the wall of the rectum and into the prostate gland.
- Transurethral biopsy—Your doctor will insert a lighted flexible tube through the penis into the urethra. The urethra carries urine from the bladder. Your doctor will get the biopsy with a cutting loop that is passed through the flexible tube.
- Perineal biopsy—Your doctor will make a small incision in the perineum. The perineum is the area between the scrotum and the rectum. The doctor will insert a small needle into the prostate gland to get the biopsy.
How Long Will It Take?
About 30 minutes
Will It Hurt?
You may have discomfort and soreness at the biopsy site. Pain and discomfort after the procedure can be managed with medications.
Postoperative Care
When you return home after the procedure, do the following to help ensure a smooth recovery:
- Stay hydrated. Drink plenty of fluids for the next few days.
- Avoid difficult physical activity the day and evening of the procedure.
- Keep in mind that you may see blood in your urine, stool, or semen for several days.
- Resume any medications that were stopped when you are advised to do so.
After the sample is taken, it will be sent to a pathologist for examination under a microscope. This doctor will analyze the sample for cancer. If cancer is present, your doctor will work with you to develop a treatment plan.
Call Your Doctor
It is important to monitor your recovery. Alert your doctor to any problems. If any of the following occur, call your doctor:
- Inability to urinate
- Blood in the urine more than 2-3 days post-biopsy
- Signs of infection, including fever and chills
- Pain that you cannot control with the medications you have been given
- Pain, burning, urgency, or frequency of urination
- Cough, shortness of breath, or chest pain
- Rectal bleeding that lasts more than 2-3 days after the biopsy
If you think you have an emergency, call for medical help right away.
National Cancer Institute
Urology Care Foundation
Health Canada
Prostate Cancer Canada
Causes, natural history and diagnosis of prostate cancer. Urology Care Foundation website. Available at: http://www.urologyhealth.org/urologic-conditions/prostate-cancer/causes. Updated April 2014. Accessed September 25, 2014.
How is prostate cancer diagnosed? American Cancer Society website. Available at: http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-diagnosis. Updated September 12, 2014. Accessed September 15, 2014.
Prostate biopsy. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T905693/Prostate-biopsy. Updated March 25, 2016. Accessed October 10, 2016.
Rodriguez LV, Terris MK. Risks and complications of transrectal ultrasound guided prostate needle biopsy: a prospective study and review of the literature. J Urol. 1998;160(6-I):2115-2120.
Tiong HY, Liew LC, Samuel M, Consigliere D, Esuvaranathan K. A meta-analysis of local anesthesia for transrectal ultrasound-guided biopsy of the prostate. Prostate Cancer Prostatic Dis. 2007;10(2):127-136.
Understanding prostate changes: A health guide for men. National Cancer Institute, National Institutes of Health website. Available at: http://www.cancer.gov/types/prostate/understanding-prostate-changes. Accessed September 25, 2014.
6/3/2011 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T905693/Prostate-biopsy: Mills E, Eyawo O, Lockhart I, et al. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.
7/13/2016 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T905693/Prostate-biopsy: Gershman B, Van Houten HK, et al. Impact of prostate-specific antigen (PSA) screening trials and revised PSA screening guidelines on rates of prostate biopsy and postbiopsy complications. Eur Urol. 2016 Mar 16.
Revision Information
- Reviewer: Mohei Abouzied, MD, FACP
- Review Date: 09/2016
- Update Date: 07/13/2016