text:
W9D1 - Great weather, didn't see anyone out this morning on my run. After the 30 minutes was over I felt like I could have gone a couple more minutes. 2 runs to go!
Started c25k on 5/30/11
Ran on the trail this hot and humid morning. It got the better of me today and I walked a half mile in the middle of my run. C'est la vie. Copper, the wretched dog, stayed home sleeping with the kids in the basement. Maybe I should have taken a cue from him. I hope everyone has a better run than I did today!
Petco Run/Walk/Wag 5k
Dig: good job. If ya have the time, why not walk a bit to increase time on feet? I did that near the end of the program so I could achieve the 5k distance. Am still to slow to cover 5k in 30 min.
Chup: heat and humidity slows one down considerably. Walking is good judgement under those conditions.
keep on keeping on!
bob e v 2014 goals: keep on running! Is there anything more than that?
Complete the last 3 races in the Austin Distance Challenge, Rogue 30k, 3M Half, Austin Full
Break the 1000 mi barrier!
History: blessed heart attack 3/15/2008; c25k july 2008 first 5k 10/26/2008 on 62nd birthday.
Giant Flaming Dork
W2D3 done on Sunday. W3D1 due for tomorrow. Amazing how much running fitness I've lost over the months. (Well, it could be the 15 extra pounds, too...)
W9D2. Wow, it was really humid today. I had to walk up a short, steep hill around the 27 minute mark, but I ran out the rest. 1 more to go!
bob: I do actually walk a few minutes after what my logs show. Today I went about another 5 minutes.
Ran 2 easy miles on the trail with the dog this hot muggy morning. This is one of those days were mother nature is making a serious attempt to kill you!.
DigitalFirefly - Way to go on W9D2!
girmann - Nice job knocking out W2!
W3D1 down. Seemed easier than W2.
Thanks Chup!
Digital Firefly: The goal is in sight, run for it!
G: congrats on completing W2! keep on keepin on!
Dig: almost there, (initial) end goal in sight!
Chup: I feel your humidity. Took my chi's out this 5:15am morning it was 80f, humid, no wind, 1.15mi their longest walk yet... Not sure I would have run outdoors the way it felt. Didn't have choice anyway had to be at DD2's to twin sit while she headed for work. DW came over later and I went to the gym for a few on the dreadmill. It was 90 and climbing by that time. I've raced in temps like that but do not want to train in it! LOL. My cardiologist would kill me if he even knew I ran in those temps!
Ran on the trail with the dog this morning. Managed to not walk and even finished faster than I had planned! I don't know how much of a factor it might have been, but I wore my technical shirt today. I will say both the dog and I were happy to see the end of the run!
Yuck, it's supposed to be 99 tomorrow for my last c25k run. I guess I'm going to run in the morning again.
Short run on the trail with the dog this morning. Crossed paths twice with a runner whose dog was off leash and charged us. And she blamed me because it wouldn't have happened if my dog had been off leash. Some people.
DigitalFirefly - Good luck on your matriculation run!
girmann - How you doing in the heat?
It was so hot out. My pace was actually pretty good through the first 20-25 minutes. The last 5 were really tough. The route I take ends pretty hilly so I was struggling. I haven't run for 3.1 straight miles yet, but I can run for 30 minutes. It's weird to think back to week 1 when I could barely run for a minute straight.
Thanks again everyone for all the support!
On the road again...
I have a love/hate relationship with running. I do it, but sometimes I love to hate it.
Nicely done!
It was so hot out. My pace was actually pretty good through the first 20-25 minutes. The last 5 were really tough. The route I take ends pretty hilly so I was struggling. I haven't run for 3.1 straight miles yet, but I can run for 30 minutes. It's weird to think back to week 1 when I could barely run for a minute straight.
Thanks again everyone for all the support!
Awesome!!! congratulations. don't sweat not covering 5k yet. It will come. It took me quite awhile to be able to run a full 5k without stopping. I really don't ever expect to finish a 5k in 30min! LOL too dang old and taking to many medications!


text:
Tag: theatre
'Heaven Can Wait' clears early acting hurdles
The Little Theatre of Alexandria's production of Harry Segall's stage play, "Heaven Can Wait," got off to a rocky start Monday night when the...
The Broadway stars are out in 'Josephine Tonight' at MetroStage
"Josephine Tonight" hurtles down the track at lightning speed with a fast-paced, musical bonanza about legendary entertainer Josephine Baker's early life and meteoric career,...
Can You Spell H-I-L-A-R-I-O-U-S?
For those of us whose middle school memories harken to a time of anxieties, crushing insecurities and the dread of not fitting in, have...
On stage, a classroom outlet
Little Theatre actors enlighten students to the fuzzy side of history
A man of many faces, one of them his wife's
The story of Charlotte von Mahlsdorf is told in the Pulitzer Prize-winning drama I Am My Own Wife, now playing at Signature Theatre
Theatre: Mighty Mahalia
Singer's legacy brought to life in Tom Stolzs Mahalia! A Gospel Musical, a no-souls barred tribute to the legendary singer, now playing at MetroStage.
Previews Begin for Signature's Le Miz
Known affectionately as Les Miz,it is one of the most successful and well-known musicals of all time, lasting nearly two decades on Broadway and winning eight Tony Awards.

subset: commoncrawl


text:
Bendigo and Adelaide Bank has reported a net profit of $189.4 million and underlying cash earnings of $169.7 million for the six months to December.
The regional lender's cash earnings were a 4.4 per cent increase from the same period the year before, while its net profit soared 227.1 per cent.
The bank declared an interim fully franked dividend of 30 cents per share.
Shares were up 3.9 per cent to $10.23.
Mike Hirst, Bendigo and Adelaide Bank's managing director, said his firm was faced with a "lacklustre demand for credit and heightened competition for retail deposits".
"Like all Australian banks we have had to adapt to these conditions, however our strategy of focusing on customer engagement and our drive to be more efficient has held us in good stead."
Mr Hirst said business conditions and sentiment improved during the second quarter of the financial year, but uncertainty remained in the market.
"In particular, we are yet to see more recent rallies in debt and equity markets translate into a material increase in demand for credit," he said.
The bank's funding costs fell in the six months to December, leading to a 10 basis point rise in its net interest margin to 2.18 per cent.
Net interest margin is a key measure of the profits made on loans.
Deposits make up 80 per cent of Bendigo's funding, and much of the funding cost reduction came from cheaper funds from wholesale markets, it said.
Mr Hirst also said costs had been contained.
Bad debt charges rose in the six months to December to $32.1 million, but they remained low as a percentage of the bank's total assets, the company said.
Bendigo declared a fully-franked interim dividend of 30 cents per share, consistent with the same period in the previous year.


text:
Submit News
Apple Releases OS X 10.8 "Mountain Lion" for $20
Brandon Hill
July 25, 2012 11:29 AM
Recipient E-mail
Sender E-mail
Apple's "other" operating system gets a major update
Windows enthusiasts around the world are waiting for the
October release of Windows 8
. However, for those of the Mac persuasion, today
marks the release
OS X 10.8 "Mountain Lion"
. Mountain Lion is the latest in a long line of OS X releases and is available for a "mere" $19.99 from the App Store.
For customers that purchased a new Mac computer since June 11, the upgrade to Mountain Lion is free from Apple.
Apple brags that Mountain Lion includes
over 200 new features
-- which are obviously too numerous to list here -- but we'll include just a couple of the highlights:
Full iCloud integration
Game Center, Reminders, and Notes
-- all three are staples of iOS, and all three are iCloud-enabled
-- another iOS transplant
Notification Center
-- most Mac users got their notifications via Growl, but now Apple is getting into the game with the -- once again -- iOS-esque Notification Center
Power Nap
-- this feature allows a Mac to still periodically check email and sync iTunes content while in a deep state of sleep. If connected to a power source, the machine will also perform Time Machine backups and download software updates.
Facebook and Twitter
-- these two social networks are also baked into the upcoming iOS 6 release
A few sites have posted reviews of Mountain Lion and the consensus is that it's a worthy upgrade to Lion.
The Verge's
Nilay Patel is overall pleased with the upgrade:
Ultimately, this is pretty easy: you should spend the $20 and upgrade to Mountain Lion, especially if you have a newer Mac. You'll gain a handful of must-have features, and everything will get faster and smoother. I haven't really missed Snow Leopard at all since upgrading, which is remarkable considering how much I disliked Lion...
Mountain Lion is the first version of OS X to deeply integrate network services at every level, from storing documents to sharing photos to connecting external displays, and it seems that much lighter for it — as though Apple's relentless charge into its post-PC era has allowed the OS X team to rethink exactly what a PC is and should be. Mountain Lion isn't perfect, but it's a confident, thoughtful step towards the future of desktop computing.
Brian Heater acknowledges that Mountain Lion is a bargain upgrade, but also notes that it seems as though OS X is mainly taking a back seat to iOS when it comes to attention/features, and that the operating system is in need of a complete "rethink":
That said, it seems time for Apple to make a bold new pronouncement on the desktop front. The company appears to have most of its resources invested in the mobile side -- and there's no question as to why: the iPhone and iPad have reinvigorated the company, making it a computing player on a scale that no one (save, perhaps, for Jobs himself) could have predicted a decade ago. Still, it might be hard for OS X users not to feel neglected -- many of the latest new features feel a bit like iOS hand-me-downs. When and if Apple rolls out a new operating system this time next year, hopefully we'll be seeing a very different side of Mac OS.
But with a price tag of just $20, Mountain Lion is a no-brainer upgrade for members of the Mac community.
The Verge
"And I don't know why [Apple is] acting like it's superior. I don't even get it. What are they trying to say?" -- Bill Gates on the Mac ads
Related Articles
Windows 8 to Arrive October 26
July 18, 2012, 7:49 PM
Quick Note: Apple Could Release OS X 10.8 "Mountain Lion" on July 25
July 16, 2012, 10:22 AM
OS X 10.8 Mountain Lion Growls at the Masses
February 16, 2012, 1:48 PM
Latest Headlines
iSO 11 is Almost Ready:
September 19, 2017, 7:48 AM
Google releases Oreo, the next version of Android
August 22, 2017, 5:54 AM
Mozilla's latest browser release will support WebVR
August 8, 2017, 6:00 AM
Facebook Chatbots Teaches Itself to become a good negotiator
July 23, 2017, 6:00 AM
Microsoft Workplace Analytics
July 6, 2017, 6:17 AM
Microsoft Delays Windows 10 Timeline Feature.
July 4, 2017, 6:39 AM
More Headlines
Most Popular Articles
Samsung Galaxy S9 – Latest Leaks
September 24, 2017, 6:57 AM
London Petition to Save Uber – 633,853 Signatures
September 24, 2017, 6:45 AM
Google Pixel 2XL will reportedly cost less.
September 20, 2017, 6:17 AM
Google Home Mini – Debuts on October 4th at Google Pixel Event
September 20, 2017, 6:58 AM
Uber faces ban in London – Loses License next month.
September 22, 2017, 7:02 AM
Latest Blog Posts
Australia joins UK space radar mission
Saimin Nidarson
Sep 26, 2017, 6:25 AM
China disrupts WhatsApp ahead of Communist Party meeting
Saimin Nidarson
Sep 26, 2017, 6:18 AM
Uber using 'aggressive' tactics says Mayor
Saimin Nidarson
Sep 25, 2017, 9:51 AM
Australia to create national space agency
Saimin Nidarson
Sep 25, 2017, 9:38 AM
Zuckerberg wants to sell 35-75 million of Facebook shares
Saimin Nidarson
Sep 25, 2017, 9:33 AM
Robot Dentist Performs World's First Dental Implant
Elroy Bethell
Sep 25, 2017, 7:24 AM
London Petition to Save Uber – 633,853 Signatures
Elroy Bethell
Sep 24, 2017, 6:45 AM
DelFast e-bike – 236 Miles on Single Charge
Elroy Bethell
Sep 23, 2017, 7:32 AM
Uber faces ban in London – Loses License next month.
Elroy Bethell
Sep 22, 2017, 7:02 AM
Google signs $1.1bn HTC smartphone deal
Saimin Nidarson
Sep 21, 2017, 6:16 AM
New Feature in Gmail Contacts and phone number link.
Saimin Nidarson
Sep 20, 2017, 6:04 AM
Google Launches UK 'Anti-Terror Fund'
Saimin Nidarson
Sep 20, 2017, 6:00 AM
New Micromax smartphone leaks
Saimin Nidarson
Sep 19, 2017, 5:53 AM
Microsoft confirms Outlook issues
Saimin Nidarson
Sep 19, 2017, 5:44 AM
Essential Phone now works on Verizon network.
Saimin Nidarson
Sep 18, 2017, 6:12 AM
Equifax data breach, a Credit rating firm replaces key staff
Saimin Nidarson
Sep 17, 2017, 6:15 AM
Cyborg Eyes may provide vision for the future.
Elroy Bethell
Sep 16, 2017, 6:00 AM
Google automatically deletes your Android backup after 2 months
Saimin Nidarson
Sep 15, 2017, 7:03 AM
Why Amazon wants to use AMD Server GPUs
Saimin Nidarson
Sep 15, 2017, 5:59 AM
A letter from US Senator to Apple CEO Tim Cook on iPhone X's Face ID
Saimin Nidarson
Sep 14, 2017, 6:20 AM
Is iPhone X price justifiable?
DailyTech Staff
Sep 13, 2017, 7:17 AM
New iPhone 8, iPhone 8 Plus, and iPhone X are now official.
Elroy Bethell
Sep 12, 2017, 2:23 PM
Apple Watch key points live from Steve Jobs theatre in California.
Elroy Bethell
Sep 12, 2017, 1:26 PM
More Blog Posts
Copyright 2017 DailyTech LLC. -
RSS Feed
About Us
Terms, Conditions & Privacy Information
Kristopher Kubicki


text:
Lasergene's Protean helps you predict and display patterns, secondary structural characteristics, and physicochemical properties of protein sequences via its comprehensive suite of protein analysis tools. Protean's simple, elegant graphical user interface can also help you locate antigenic determinants and predict protease digestion patterns. Protean provides you with the tools to easily annotate and export your findings as reports, pictures or tables, and is fully integrated with GenVision, allowing for the creation of publication-quality images of your annotated sequence.
- Analyze protein structure from a diverse selection of methods for secondary structure, hydropathy, antigenicity, amphiphilicity, surface probability and flexibility
- Apply methods for recognizing alpha helix, beta sheet, turns and coil structures
- Predict the presence of post-translational sumoylated sites to assist in the study of a wide range of cellular activities
- Locate patterns and related sequences using Prosite, including pattern searching for biologically significant motifs
- Predict Proteolytic digestion sites and display the recognition sites
- Simulate electrophoretic separation of proteolytic fragments


text:
McClendon gives Ackley rest for finale
PHILADELPHIA -- Though Dustin Ackley has been swinging a hot bat of late, Mariners manager Lloyd McClendon gave the outfielder a day off from the starting lineup on Wednesday to rest a sore back and also take advantage of Thursday's off-day.
"It's a chance to give him two days, actually," McClendon said. "He's been going at it real hard. This is a chance to get him cleaned up and ready for the stretch run. I just thought we should take advantage of it."
McClendon did summon Ackley to pinch-hit in the eighth inning of the Mariners' 4-3 loss to the Phillies, and Ackley struck out with a runner on second.
Ackley, who went 4-for-7 with three doubles in the first two games of the series, is hitting .313 in 31 games since the All-Star break to hike his average to .252.
Ackley had started 33 straight games prior to Wednesday, and he's dealing with some minor issues, but nothing serious.
"He's dinged up," McClendon said. "Everybody is dinged up this time of year. He's got a little sore back, but he's OK. This will freshen him up and get him off his legs for two days, and we'll get him back in there."
Greg Johns is a reporter for MLB.com. Follow him on Twitter @GregJohnsMLB as well as his Mariners Musings blog. This story was not subject to the approval of Major League Baseball or its clubs.


text:
NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Wednesday, September 20, 2017
Minimal PTB
I was diagnosed minimal PTB last 2002, but I only took medicine last 2006. I did all my doctor said like CT scan, sputum and lot of xrays. After my medication my doctor says that it`s ok now. This is my last result of my xray which said left upper lobe nodular densities has no change. I did xray again outside and it said left subclavicular fibronodular infiltrates due to PTB. My doctor said that its only a scar -- that it can`t be cured by medicine but in surgery. Is it true? Is there any option or medicine for this and why when I did xray the finding was not a scar? Thank you.
Sometimes it is difficult for us to answer a question when we do not have all of the facts.
I am not sure what "minimal PTB" is. I am also not sure if you were diagnosed and treated for "active" TB disease (symptoms of fevers, chills, and cough, night sweats) or you were diagnosed and treated for latent TB infection (no signs or symptoms of TB disease, positive tuberculin skin test).
If the dates you listed are correct, (diagnosed in 2002 and treated in 2006), then you most likely did NOT have active TB disease. Your doctor must have been concerned about active TB disease by ordering sputa and CT scans.
After an infection of the lung with TB, you will have areas that are abnormal on CXR or CT scan. These areas may or may not improve after you have completed treatment. Your medical doctor may refer to these abnormal areas as "scars" and the radiologist may refer to these same areas in radiological terms. Other infections such as bacterial, fungal, and even non-infectious causes such as chemicals can cause abnormalities on CXR.
What is important is that you were medically evaluated for the abnormal areas, treated, and the areas are not getting worse. If you are having pulmonary symptoms of shortness breath, fever, weight loss, fatigue or chest pain then you will need further evaluation.
In the future, if you were to get another CXR or CT scan of the chest, be sure to let your doctors know that you had an abnormal CXR/CT scan in the past. Then the doctors can compare your new radiological studies to the old ones to determine if there is no change in these areas or if there is a NEW area of abnormality.
Shu-Hua Wang, MD, MPH&TM
Clinical Assistant Professor of Infectious Diseases
Clinical Assistant Professor of The Division of Epidemiology
College of Medicine
The Ohio State University
Larry S Schlesinger, MD
Molecular Virology, Immunology and Medical Genetics
Microbiology Administration
Environmental Health Sciences
College of Medicine
The Ohio State University


text:
I have a real sneaky feeling Bird is talking about Roko-Leni Ukic a 6-5 combo guard from Europe . Ukic , is being compared to Manu Ginobili . A very solid defender ( by Euro standards) to takes it to the hole. Just a wild thought.
Really its intresting Larry envision someone that good lasting that long that he'd be an impact player. We know Bird used Luke Jackson as a smoke screen wanting Ben Gordan all along. Gordan ,proved Larry was right about his value
I think the Bender deal was possible until Larry worked out someone he fell in love with.
The question is just who is this mystery guy? I think if Larry has 4 guys ,he feels can help at #17 the Bender thing is dead. Question is has Larry zeroed in on someone in particular? If he has I'd not be suprised to see Larry use Fred Jones and our pick to move up enough to insure getting him.
The little smile and comment - "He'll play ,even if I have to coach him " tells me Larry thinks he knows something about someone other NBA GM's don't.
As this draft nears , Larry's comments makes it very intriguing just what he has up his sleeve for the Pacers.


text:
Note: This item is more than 13 years old. Please take the publication date into consideration for any date references.
Print – Plain Text – Permalink
News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
June 21, 2004
Stay Tuned
Information from Texas Parks and Wildlife is available on radio and television, as well as the newsstand.
Passport to Texas, TPWD's radio series of weekday, 90-second stories is broadcast on about 100 Texas stations. Airing the week of June 21-25, Bass fishermen can now proclaim their love of the sport...on their boat trailers. Plus, we'll introduce you to a man who really likes to hike, and we're not just talking a walk in the park.
For more information, visit the Web (http://www.passporttotexas.org/).
Video News
TPWD provides video news reports that run in newscasts on numerous Texas stations, as well as on cable and satellite outlets around the nation.
"Texas Parks & Wildlife" is a weekly half-hour television series seen on PBS affiliates around the state. The episode that airs the week of June 20-27, Sport fishing on the Texas coast; the spirit of Hueco Tanks; boating safety checks; preserving the hardwoods of East Texas; and panhandle prairie dogs.
For more information about this week's programs and where they can be viewed, visit the Web (http://tpwd.texas.gov/tv).
Texas Parks & Wildlife magazine is always available on newsstands throughout the state and by subscription for $19.95 a year. To subscribe, call (800) 937-9393 or order online (http://www.tpwmagazine.com).
Publication — Permission is granted to publish, in whole or in part, any news releases on this page.
Print — A print-friendly version of the news release shows only the release with font sizes set to the browser default.
Plain Text — Plain text versions of TPWD news releases are provided for copying and pasting into editing software.
To copy text into an editing software:
- Click a Plain Text link to display the plain text page in your browser.
- Select all.
- Copy.
- Paste in a document in your editing program.
Permalink — This is a direct link to the news release, omitting the navigation context from the URI.
English/Spanish — News releases posted in both English and Spanish have one of these links.
If you have any suggestions for improving these pages, send an e-mail to email@example.com and mention Plain Text Pages.
(5.4.16 i)


text:
University Construction Projects Bill Sails Through House
By Associated Press • Feb 7, 2013
FRANKFORT, Ky. -- The University of Kentucky's football stadium would get a facelift under legislation approved by the House on Thursday.
Six public universities would spend $363 million on construction projects under the legislation that cleared the House on a 97-1 vote.
The biggest expenditure would be $110 million to renovate UK's Commonwealth Stadium. Morehead, Murray, Northern and Western Kentucky universities also would get upgrades, as would the University of Louisville.
The legislation now goes to the Senate for consideration.
The top selling points for the proposal are that the projects will be paid for by the universities without any General Fund money and that they will create more than 5,000 construction jobs.


text:
Hello. I am Gertrude. Nice to meet you all. Thanks for allowing me into your group!
'); var yuipath = 'clientscript/yui'; var yuicombopath = ''; var remoteyui = false; } else // Load Rest of YUI remotely (where possible) { var yuipath = 'http://yui.yahooapis.com/2.9.0/build'; var yuicombopath = 'http://yui.yahooapis.com/combo'; var remoteyui = true; if (!yuicombopath) { document.write('
Hello. I am Gertrude. Nice to meet you all. Thanks for allowing me into your group!
Welcome to PD.
You know how hippos are made out to be sweet and silly, like big cows, but are actually extremely dangerous and can kill you with stunning brutality? The Pacers are the NBA's hippos....Matt Moore CBS Sports....
Hi! Welcome to PD.
Great name, by the way. Not by chance a Hamlet fan, are you?
You, Never? Did the Kenosha Kid?
Are you doing kartwheels all over this bish?
Hi! Great to be on the Pacers Digest!


text:
BOWLING GREEN, Ky. — Fruit of the Loom has chosen Crispin Porter + Bogusky to oversee and manage advertising for the Fruit of the Loom, Vanity Fair and Russell Athletic brands.
The leading international, vertically integrated basic apparel and athletic goods company's brands include Fruit of the Loom, Vanity Fair, Russell Athletic and Spalding. It is an independent wholly owned subsidiary of Berkshire Hathaway, which is chaired by Warren Buffett.
One of the world's largest manufacturers and marketers of underwear, intimate apparel, casualwear, athletic apparel and equipment, Fruit of the Loom is looking to CP+B to build on the momentum started with the heritage brand's new campaign launched during the 2012 Summer Olympics.
"We are thrilled to bring on board such a stellar ad agency as CP+B," says Kelly Thompson, SVP, brand communications, Fruit of the Loom. "Their fresh perspective will infuse bold, creative thinking on the marketing of our brands that will strengthen consumer engagement."
"We are truly excited about the opportunity, and to help create some new momentum with the American consumer," says Steve Babcock, VP and executive creative director, CP+B.
With a list of clients which includes Kraft, Best Buy, Microsoft, Old Navy and Arby's, CP+B, Boulder was one of four finalists in Fruit of the Loom's search. It was named "Interactive Agency of the Year" three times at the Cannes Lions International Advertising Festival, "Agency of the Decade" by Advertising Age and "Agency of the Year" 13 times in the trade press. It is the only agency to have won the Grand Prix at Cannes in every major category.
Fruit of the Loom tries on new ad agency
BOWLING GREEN, Ky. — Fruit of the Loom has chosen Crispin Porter + Bogusky to oversee and manage advertising for the Fruit of the Loom, Vanity Fair and Russell Athletic brands.


text:
Lindor kicks off 2014 season at Double-A Akron
Shortstop Francisco Lindor, the Indians' No. 1 prospect, got off to a solid start to the season in Double-A Akron's Opening Day 7-1 victory at Binghamton, N.Y. He went 2-for-5 with a stolen base and a run on Thursday.
After a long offseason and Spring Training, Lindor said he was just happy to get back on the field for a competitive game.
"I was really excited," said Lindor, who is ranked No. 10 on MLB.com's Top 100 prospects list. "I was stoked because every time you get to play on Opening Day, it's good. After a while, you get tired of Spring Training and you're ready to get out of there and a play real game."
Lindor leads a prospect-laden team in Akron. He is joined by right-hander Cody Anderson (No. 4 on the club's prospect list), center fielder Tyler Naquin (No. 5), catcher Tony Wolters (No. 9), second baseman Joe Wendle (No. 11), infielder Ronny Rodriguez (No. 13) and left-hander Kyle Crockett (No. 17). All seven appeared in the win. Anderson allowed one run on four hits in six innings to earn the victory, and Wolters added two hits and an RBI.
After climbing through the Minor Leagues with most of his teammates, Lindor said he knows how good the RubberDucks are capable of being and was glad they were able to start the season on the right foot.
"I'm happy we got the W," Lindor said. "It's good to get the first one out of the way."
Lindor has shot through the Minor Leagues since the Indians selected him eighth overall in 2011. He is considered to be among the best defensive shortstops in the Minor Leagues, and hit .303 with 25 stolen bases between Class A Advanced Carolina and Akron in 2013.
Thanks to his late-season promotion to Akron last year, Lindor is closing in on his Major League debut. He said he hopes to improve as much as possible this season so he'll be prepared when he gets the call.
"I'm just trying to be the best player I can be," Lindor said. "That way I'm ready when that day happens that I get called up to the big leagues."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. Teddy Cahill is a reporter for MLB.com. Follow him on Twitter at @tedcahill. This story was not subject to the approval of Major League Baseball or its clubs.


text:
detrop wrote:To me, terms like "stream of consciousness" ... "storage of impressions" ... "stream of kamma" ... "dying and being born every single moment" raise much more questions than they possibly answer. Their accessibility in real life is not better than that of the good old permanent Self - both can be assumed all day long, but none of them can be actually found by someone like me.
well according to the dhamma one can master the jhanas and literally see ones past lives. however this is a side track. in reality one does not need to know anything about rebirth at all. one can simply practice the dhamma, see through reality bit by bit and eventually enter nibbana never knowing a thing about rebirth being real or not.


text:
Sierra Leone's Leone Stars win 2011 Los Angeles African Community Soccer Tournament
Two Day Event to take place Sept. 1 and 15th at Griffith Park Soccer Fields and Carson's Home Depot Center
Soccer enthusiasts are set to gather for the 2012 Los Angeles African Soccer Tournament taking place Sept. 1 at the John Ferraro Soccer Fields at Griffith Park (5101 North Zoo Drive) in Los Angeles, Calif. 24 teams representing 21 countries are set to compete in the second annual soccer tournament featuring the best African and West Indian semi-pro and amateur soccer players in the Los Angeles area.
On Sat. Sept. 1., from 8 a.m. to 6 p.m. Angelinos will be treated to a fun and competitive soccer event showcasing Los Angeles' African, West Indian, and American soccer players including a parade, exhibitors, music, contests, a special youth soccer clinic hosted by the L.A. Galaxy, and an international food court featuring the best in African and West Indian cuisine.
On Sat. Sept. 15, Carson's Home Depot Center (18400 South Avalon Boulevard) will host the semi-final and final games during their African Heritage night from 2 p.m. to 7 p.m. Both events are free and open to the public.
A CalSouth sanctioned event, new teams this year include the L.A.P.D. Centurions, Belize, and Angola. Returning countries include: Zambia, Uganda, Togo, Tanzania, Sudan, South Africa, Senegal, Rwanda, Nigeria, Namibia, Morocco, Kenya, Ivory Coast, Guinea, Ghana, Eritrea, DR Congo, Cameroon, and the USA. In addition, there will be a special showcase highlighting women in soccer.
The following are the tentative team drawings for tournament:
Group A
Black Stallions (Ghana)
Selam (Eritrea)
Bafana Bafana (South Africa)
Sundanese L.A. (Sudan)
Group B
Black Eagles (Nigeria)
Griga FC (Belize)
Might Elephants (Ivory Coast)
Bongo Starz (Tanzania)
Group C
L.A. Veterans (Nigeria)
Syli Nationals (Guinea)
Amavubi (Rwanda)
LAPD/LAFD Centurions (USA)
Group D
L.A. Lions (Cameroon)
Cali Harambee (Kenya)
The Hawks of Kadou (Togo)
B-Town Stars (Mauritania)
Group E
Moroccan Rockets (Morocco)
Leopards (DR Congo)
Lions Teranga (Senegal)
The Copper Bullets (Zambia)
Group F
Camsola (Cameroon)
Brave Warriors (Namibia)
Les Eperviers (Togo)
Simba United (Uganda)
Produced by Vuvzela Media and Marketing Co., the event is sponsored in part by Soccer Shop USA, Money Gram International, Red Cross International, Afrozon, Fatal Cut Entertainment, Chivas USA, New Designs Charter School, Turkish Airlines, South African Airlines, Clear Essence Cosmetics, African Trumpet, Carib Press, Immigrant Magazine with support from the Los Angeles Police Department and the Los Angeles Fire Department.
For more information, please call (323) 993-8662 or email www.africansoccerla.com.
According to the U.S. Census, it is estimated that the current population of African immigrants to the United States is about 881,300. In Los Angeles County there are about 26,000 Africans representing almost 3 percent of the black population. African countries in Los Angeles County with the most immigrants include Ethiopia, Nigeria, Ghana, and South Africa.


text:
by T.W. Budig
ECM Capitol reporter
Lawmakers may dispute who can take credit, but the February budget forecast released on Wednesday, Feb. 29 nonetheless short-term was devoid of red ink — the second upbeat forecast in a row.
Because of existing state law, the $323 million budget surplus projected for the current two-year spending cycle automatically was absorbed.
"We have a zero balance again," said Management and Budget Commissioner Jim Schowalter.
Some $5 million was siphoned to replenish the state budget reserve — the reserve is now at $653 million.
The remaining $318 million, again, by law, was directed towards reducing the school funding shifts that lawmakers have crafted in recent times as a method of balancing the state budget. Some $200 million of the repayment will be sent to the schools in March.
Still, some $2.7 billion in school payment and property tax shifts remain to be paid.
And a look out into the next spending cycle shows about a $2 billion, inflation factored, state budget deficit in addition to the borrowed billions.
But State Economist Tom Stinson said in general the economy is improving. Global Insight, the state's budget forecaster, has reduced the possibility of a recession this year from 40 percent to 25 percent.
"Of course there are no guarantees," he said.
Beyond possible geopolitical shots to the economy, there are a number of things on the federal level, such as the expiration of the Bush taxes cuts, that depending on how they're handled could affect the economy, Stinson explained.
Lawmakers, like the budget numbers, were generally upbeat.
House Speaker Kurt Zellers, R-Maple Grove, while attributing the reviving state budget to hard-working Minnesotans kicking in revenue, also credited House and Senate Republicans with sound fiscal management.
"We're excited, we're pleased, we're happy," said Senate Majority Leader David Senjem, R-Rochester, of the budget news.
Zellers indicated that House Republicans were not interested in any additional state spending. "We intend to be out of here early," he said of a possible early close to the legislative session.
Zellers said House Republicans are eager to address a number of remaining issues — he pointed to the so-called First In, Last Out legislation pertaining to teacher effectiveness and layoff retention as one worthy item.
Senjem, though not suggesting how big of a bonding bill Senate Republicans wanted, indicated Republicans do want one.
But the idea that it's possible to buy the state a new economy is foreign to Republican philosophy, he explained.
Democratic Gov. Mark Dayton explained the state had a long way to travel to get out its budget hole. Realistically, paying off the remaining $2.7 billion in shifts will take time, he explained.
Dayton, who said he will presenting a supplemental state budget within a few days, spoke of being watchful of the impact any spending proposal would have on the next spending cycle. He found it hard to believe, he said, that Republicans would take credit for the budget reversal.
"I'd say to the Legislature, 'Where's the jobs' bill?'" said Dayton. "That should be the top priority."
House Minority Leader Paul Thissen, DFL-Minneapolis, and Senate Minority Leader Tom Bakk, DFL-Cook, also expressed surprise that Republicans were taking any credit for nursing the state budget back to health.
Indeed, Thissen spoke of a perceived "giddiness" among the Republicans over the budget forecast and said it should worry the public.
On the issue of the Vikings' stadium, the House and Senate Republican leaders have not helped move the issue along, Dayton explained.
"No one else has helped with the heavy lifting," he said.
Stinson, in discussing the bonding bill, said that the greatest job creation impact the bill could have is if it focuses on state asset preservation.


text:
Dr. Elena Berkowitz MD
- Dermatology Great Neck, NY
Vitals cannot verify whether or not this professional is currently practicing. We recommend that you attempt to contact the provider to verify their status. Please email us at firstname.lastname@example.com if you have any additional information.
Dr. Elena Berkowitz, MD is a Doctor primarily located in Great Neck, NY. She has 50 years of experience. Her specialties include Dermatology. Dr. Berkowitz is affiliated with Nassau University Medical Center. She speaks English.
Find out the languages this doctor/ or staff may speak.
View all
Learn where this doctor attended medical school.
View all
Specialties & Expertise
Dr. Elena Berkowitz has the following 5 areas of expertise and 1 specialty.
A dermatologist is a doctor who has extensive training and knowledge of the skin, scalp, hair and nails and treats conditions that affect those areas. These doctors will evaluate any abnormality, blemish or lesion on the skin in order to determine the cause and will determine a course of treatment.
Dermatologists provide patients with full body scans in order to identify any signs that are indicative of an illness that requires treatment, such as skin cancer. These specialists may also provide cosmetic services, such as mole removal, scar diminishing treatments and even botox and face lifts.
See areas of expertise for treating specific conditions, procedures and surgeries for this doctor.
View all
Health Guides
Metastatic Melanoma
The facts about metastatic melanoma, a serious skin cancer, including signs, symptoms & what happens to the body in each stage of cancer.
more health guides
Locations & Directions
Nearby Doctors
Dr. Elena Berkowitz, MD is similar to these 3 Doctors near Great Neck, NY.


text:
J. O'Neal makes impact with leadership skills
Milton Kent -- On the NBA
Originally published February 29, 2004
Indiana Pacers coach Rick Carlisle has seen Jermaine O'Neal come a long way since Carlisle coached O'Neal in the Utah summer league in 1996 when both were with the Portland Trail Blazers.
So, when Carlisle hears that O'Neal believes his leadership is the best part of his game, the coach isn't surprised.
"I believe that Jermaine realizes at this point in time in his career and where this team is, a lot of the most valuable tangible things he can bring to this team are stability and leadership," Carlisle said recently. "To me, this year, he's really helped guys around him become better."
Carlisle says O'Neal, on the short list of candidates for NBA Most Valuable Player, has helped center Jeff Foster develop the confidence that he belongs in the starting lineup, where he landed when the Pacers traded Brad Miller in the offseason.
And O'Neal played a key role in helping Ron Artest control his passions and become an All-Star forward.
"He's been a constant in terms of being the source of encouragement for our younger guys," Carlisle said. "Those types of things don't show up in the stats or in the box score, but ... they are essential if you're going to be a winning team."
For the 6-foot-11 O'Neal, who sat largely unused on the Portland bench for four years until he was traded to Indiana in 2000, becoming the leader of the Pacers, the Eastern Conference's top team, is because Reggie Miller let him lead.
"Once I got to Indiana ... [I] was able to watch Reggie Miller not only talk about it, but he practices what he preaches," said O'Neal, who was 15th in the NBA in scoring and ninth in rebounding before last night's games. "Every day, it's about basketball, and it's about what you do off the court that can make everybody else around you take to you and make everybody else that's around you better.
"Right now, he's kind of passed the torch, and two years ago, before the New Jersey series, he told me that we would go as far as I took them and that meant a lot to me. To hear that from a Hall of Famer and one of the greatest players to ever play the game and to have him say that to me at that particular point, that meant a lot to me."
With Artest out of the lineup indefinitely with a wrist injury, the mantle of leadership will likely fall harder on O'Neal. Chances are pretty good that his shoulders will be able to handle it.


text:
If you are looking for Real Estate in Westampton NJ, you have come to the right place. Here you will find Homes for Sale,Townhomes / Condos for Sale as well as Adult Communities. Westampton NJ is serviced by the Westampton Township School District.
If you are ready to start your house search or to get your house sold please reach me at my email address firstname.lastname@example.com or call / text me anytime at 609-304-1057. I am ready to help.
Dogwood Estates Homes for SaleChange this Search Criteria
The data relating to real estate for sale on this website comes in part from the IDX Program of Garden State Multiple Listing Service, L.L.C. and RE/MAX of New Jersey. Real estate listings held by other brokerage firms are marked as IDX listing. Information deemed reliable but not guaranteed. Copyright © 2017 Garden StateMultiple Listing Service, L.L.C. All rights reserved. This information is being provided for Consumer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties Consumers may be interested in purchasing
The dissemination of listings on the website does not constitute the consent required by N.J.A.C. 22.214.171.124 (n) for the advertisement of listings exclusively for sale by another broker. Any such consent must be obtained in writing from the listing broker.
© 2001-2017 Reliance Network and RE/MAX of New Jersey.
All rights reserved. US Reg. Copyright TX-5-910-991, TX-5-910-992, TX-5-910-993, and TX-5-910-994.
Each RE/MAX® Office is Independently Owned and Operated. Equal Housing Opportunity.


text:
Remember me
Forgot your password?
Location: Irvine, Calif.
History: Formed 18 years ago. Now has the most Gold and Premier teams of any Southern California club.
Championships: Two USYSA Region IV titles (1 boys, 1 girls).
Most famous players: David Chun, Jordan Harvey, Tyson Wahl (U.S. U-17 national team members).
Number of players: 500 ...
JoinJoin 180K soccer fans for Free SoccerAmerica Membership »


text:
Phoenix House Academy in Los Angeles
Lake View Terrace, California
Our compassionate care and family counseling help teens launch healthy and substance-free lives.
Established in 1994, Phoenix House Academy in Los Angeles is an evidence-based residential treatment program for 110 youth ages 13-18 affected by addiction and/or mental health disorders. Residents attend a fully-accredited on-site high school while receiving comprehensive drug and alcohol addiction treatment services, including: individual and group counseling (mental health, substance use disorder, trauma, and anger management); family therapy (parent education, group counseling); art and music therapy; cultural and recreational activities; and a broad range of life skills training. The Academy's extensive grounds feature two-person bedrooms, classrooms, sports facilities, gyms, a computer lab, and a fully-equipped professional music studio – home to the Phoenix Rising Music Program.
Phoenix House Academy's Outpatient Services offer outpatient and intensive outpatient day treatment to teens ages 13-20 who struggle with substance-use-related disorders. Services include individual and group counseling: mental health counseling; case management; educational workshops; family services; and substance-free recreational opportunities. Evidence-based addiction and mental health treatment techniques are used to address such issues as trauma, depression, anger management, and behavioral disorders. Youth and family counseling is also available in the community in local high schools. Drug and Alcohol Prevention Services are provided in schools and communities of north-east San Fernando Valley.
The Academy is licensed by the California Department of Alcohol and Drug Programs. It is fully accredited to provide treatment for co-occurring mental health and substance use disorders by the California Alliance of Child and Family Services and by the Commission on Accreditation of Rehabilitation Facilities (CARF).
Find Us11600 Eldridge Avenue
Lake View Terrace, CA 91342
1 888 671 9392
Admission Counselor
Charles Richardson
1 888 671 9392
Our Team
Shawna Morris
Treatment Approach
Our treatment philosophy is based on the understanding that addiction is a chronic disease. Individuals suffering from substance use disorders deserve evidence-based treatment in settings that offer privacy and dignity.
Insurance and Payment Options
Our experienced staff is skilled at working with all types of insurance providers to help you access the treatment you need. Phoenix House is an in-network provider for most major insurance carriers, managed care programs, and Medicaid.
Do your programs accept insurance?
Yes, Phoenix House California accepts most insurance plans, including: Aetna, Anthem Blue Cross, LifeSynch-Humana, APS Healthcare, MHN, Cigna, HealthNet, and Value Options. We also accept United Behavioral Health and partners.
What is your policy towards involving family members?
Family involvement is an integral component in the treatment process. Individual family sessions, multifamily group therapy sessions, and parent and significant other education groups are offered as part of each client's individualized treatment plan. Phoenix House invites families to special informational and educational sessions, provides them with appropriate printed resources in English or Spanish, (including… more
Will I be able to continue working and/or go to school while in treatment?
Individualized treatment plans are designed by each client and his or her therapist, taking into account goals and provisions for continued employment and/or education.
Our Core Services
Assessment and Evaluation Services
In various locations, Phoenix House provides independent assessments and evaluations of substance use disorders as requested by individuals, families, schools and the Criminal Justice System.
More Details
Adolescent Residential Services
The Phoenix House Academies for Youth offer intensive substance abuse and mental health services with high school academic programs in CARF-accredited facilities.
More Details
Mental Health Services
Substance abuse and addiction often go hand-in-hand with mental health issues, and Phoenix House offers treatment programs designed specifically to meet this need.
More Details
Prevention and Education Services
Phoenix House's prevention and education services highlight the dangers of drug use, reinforce self-esteem, and educate youth and adults to make positive choices.
More Details
Adolescent Outpatient Services
Phoenix House adolescent programs provide treatment in a safe, supportive environment that gives youth and their families a chance to break free from substance abuse.
More Details
Additional Services
High School
Los Angeles County Office of Education maintains a fully accredited high school on-site. Academic tutoring is available for those who are unable to attend school on a daily basis. In an effort to create educational continuity, all students are instructed through self-paced educational materials.
Family Services
Our services include counseling, family therapy, parent education, and group activities for families of adolescents in treatment.
Recreation and Fitness Program
A full-time coordinator and team of coaches and recreation therapists assess each teen's fitness level and help them set personal fitness goals. Three times a week, teens participate in planned indoor and outdoor activities, which are supplemented by dance, yoga, and recreational outings.
Phoenix Rising Music Program
An on-site music studio gives our residents an extraordinary creative outlet where they can write and record their own music and an opportunity to learn valuable skills.
Medical and Nursing Services
Health, medical, and dental services are provided by staff nurses, consulting physicians, psychiatrists, psychologists, and dentists, and through partnerships with community clinics and medical centers.
Speakers Bureau
Young residents enrolled in treatment participate in community outreach activities to teach their peers about the dangers and consequences of substance abuse. Residents appear as speakers at sessions, classes, and panels held at local schools, community centers and other locations.
Speak Up! Workshops
These small group workshops are designed to promote better understanding between at-risk youth and the police.
Phoenix Rising Music
Our California Teens Sing Their Hearts Out
With the help of Grammy-nominated singer/songwriter Kara DioGuardi, teen clients in our Phoenix Rising Music Program tell their stories and heal through song. In their own words, our state-of-the-art recording studio and expressive arts program exemplifies "love, vision, joy, and determination."


text:
Acrid MoronThese brain teasers rely on your ability to recognize groups of common attributes. For each of these puzzles you'll need to figure out why the words or letters are grouped as they are. Sometimes you will be asked to pick the odd-one-out or to place a new word into the correct group.
Which word in Group B can be added to Group A? Why?
Group A: acrid, coral, first, moron
Group B: borax, horse, jerky, screw, unrig, vireo
AnswerEach word in Group A, when the "r" is removed, makes a new word.
acrid - acid
coral - coal
first - fist
moron - moon
horse - hose
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
Back to Top


text:
The heavy rains that soaked south Louisiana in early January hurt the strawberry harvest, and left some fruit rotting in fields, but conditions have greatly improved, according to the LSU AgCenter.
In the last two weeks, some areas in Tangipahoa Parish have had as much as 13 inches of rain, Sandra Benjamin, the AgCenter county agent for the parish, said in a news release. Farmers were not able to get in fields to control diseases.
"A lot of strawberries had to be thrown away due to gray mold and rot," Martin said.
During the periods of light rain, however, farmers were able to pick some of their berries to sell.
"The weather we are having now is good for the berries," Benjamin said. "The coming days should be sunny, which will allow the fields to dry up."


text:
Advance Transformative Models
Develop and spread effective models of education that promote global competence and deep learning for all students
International Studies Schools Network
Global competence at the core of a national school reform model.
Graduation Performance System
Driving global competence and deep learning through performance-based learning and assessment.
Global Competence Certificate
Certifying teachers of global competence through innovative online learning.
Afterschool Learning
Promoting global competence in afterschool learning.
Make Mandarin Mainstream
Catalyze exponential growth in the number and quality of Chinese language programs and connections to China.
Chinese Language Initiatives
The United States has a shortage of Chinese language speakers—here's our response.
Confucius Classrooms Network
A national network of over 100 model Chinese language programs in the US and partnerships in China.
National Chinese Language Conference
The premier national conference dedicated to Chinese language and culture.
Cultivate Innovation at Scale
Convene premier education leaders in US and Asia to spark innovations that promote global competence and high achievement for millions.
Global Cities Education Network
Major school systems in the United States and Asia work together to overcome common challenges.
States Network for International Studies
U.S. state policymakers share best practices and models to prepare students for the global innovation age.
Connect Young Leaders
Network emerging leaders in the US and Asia to develop global competence and change the world.


text:
NICKY Henderson admits he is facing a severe headache in keeping all his Champion Hurdle prospects apart during this wet winter.
While the Seven Barrowx trainer showed off three horses as possibilities for the williamhill.com Christmas Hurdle at Kempton as part of a press visit to his Lambourn stable, Binocular appears the only one of the trio to be a certain runner there.
JP McManus' slick gelding has landed the Grade One twice in a row, beating Rock On Ruby last Boxing Day before finishing fourth to him in the Champion itself.
"He'll definitely go straight to Kempton - he's in good form and might have a racecourse gallop," Lambourn handler Henderson said.
From there, it gets tricky for a handler who has taken the Cheltenham crown five times already.
Another of owner JP McManus' stars Darlan, who was second in the Supreme and then a winner at Aintree, has missed one possible outing because of the deep going at Cheltenham's Open meeting, and may lose out again in Saturday's StanJames.com Fighting Fifth Hurdle at Newcastle.
"I was talking to AP McCoy and we don't think he likes soft ground so we'd be loathe to run him at Newcastle," Henderson said.
"Even if it was called off and moved to Newbury, as they have done before, it would be heavy ground there too.
"I'm not sure JP would want to run them both at Kempton either. It's an impossible situation."
The trainer has pencilled in Grandouet for next month's StanJames.com International Hurdle at Cheltenham, scene of his most recent outing and victory almost 12 months ago.
"Grandouet worked really well this morning and will go to Cheltenham," Henderson said.
"He injured a near-hind joint, but Barry Geraghty sat on him last week and said he felt great. If he runs at Cheltenham, he wouldn't go to Kempton."
Henderson pitched another smart hurdler into the mix in Cash And Go, who was second in the valuable handicap at the Open on his debut since leaving Edward O'Grady.
"I think he might be worth another run in a good handicap, so will go for the Ladbroke at Ascot, I suppose," he said.
Oscar Whisky will again run in the Relkeel Hurdle at next month's Cheltenham meeting.
Henderson is biding his time before unleashing top hurdler Simonsig over fences.
The trainer had suggested the runaway Cheltenham Festival winner could make his chasing debut at Newbury, but Simonsig is not quite primed for the task.
Henderson said: "He's not quite ready for this weekend, we'll see him in about a fortnight."
Captain Conan, who impressed on his recent debut over fences at Cheltenham, will take his next step up the ladder in the Henry VIII Novices' Chase at Sandown next weekend.
A belated reappearance from injury-hit 2009 Champion Hurdler Punjabi, also expected to go chasing, should come soon.
"I had him entered this week but I wasn't going to risk him on this ground," the trainer said.
Hennessy Gold Cup favourite Bobs Worth's participation in Saturday's big race will not be confirmed until trainer Nicky Henderson has walked the course at Newbury and spoken with connections.
The trainer was inspecting the Berkshire track on Tuesday afternoon as he is worried about potentially heavy ground and wanted time to mull over his thoughts.
A dual Cheltenham Festival winner, Bobs Worth has not been seen since beating First Lieutenant in the RSA Chase last March.
"We're nervous about it (the ground) and I can't just make a decision," he said.


text:
Clofarabine and Low-Dose Total-Body Irradiation in Treating Patients With Acute Myeloid Leukemia Undergoing Donor Peripheral Blood Stem Cell Transplant
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Acute Myeloid Leukemia
|Procedure: Allogeneic Hematopoietic Stem Cell Transplantation Drug: Clofarabine Drug: Cyclosporine Other: Laboratory Biomarker Analysis Drug: Mycophenolate Mofetil Procedure: Peripheral Blood Stem Cell Transplantation Other: Pharmacological Study Radiation: Total-Body Irradiation
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase II Study of Optimally Dosed Clofarabine in Combination With Low-Dose TBI to Decrease Relapse Rates After Related or Unrelated Donor Hematopoietic Cell Transplantation in Patients With AML
- Efficacy of the optimal dose of clofarabine combined with 2, 3, or 4 Gy total body irradiation (TBI) in reducing the relapse rate in patients with acute myeloid leukemia (AML) compared to our historical experience with fludarabine and 2, 3, or 4 Gy TBI [ Time Frame: At 6 months ]Rate of disease relapse or progression, defined as the presence of > 5% blasts by morphology on a marrow aspirate or the presence of circulating blasts in the peripheral blood. A satisfactory improvement will be considered declines from 35% to 20% among high-risk and from 15% to 5% among low risk patients (low risk group terminated August 2014).
- Optimal dose of clofarabine in combination with 2, 3, or 4 Gy total body irradiation (TBI) in preparation for hematopoietic cell transplantation (HCT) from HLA-identical related and HLA-matched unrelated donors in patients with acute myeloid leukemia [ Time Frame: Day 14 after HCT (21 days after initiation of clofarabine) ]Optimal dose of clofarabine in combination with TBI in preparation for HCT from HLA-identical related and HLA-matched unrelated donors in patients with acute myeloid leukemia, will be assessed.
- Engraftment rate [ Time Frame: At day 100 ]Engraftment rate will be determined.
- Leukemia-free survival [ Time Frame: Up to 5 years ]Leukemia-free survival will be evaluated.
- Minimal residual/recurring disease [ Time Frame: Up to 5 years ]Intensified monitoring by more frequent leukemia assessments and by adding molecular methods to improve leukemia-free and overall survival.
- Non-relapse mortality (NRM) rate [ Time Frame: At day 100 ]NRM will be assessed.
- Overall survival [ Time Frame: Up to 5 years ]Overall survival will be evaluated.
- Pharmacokinetics (PK) of clofarabine [ Time Frame: After the first clofarabine infusion at 2, 3, 4, 5, and 6 hours; prior to the 2nd, 3rd, 4th, and 5th doses of clofarabine; within 2 hours before the infusion of peripheral blood stem cells ]PK of clofarabine will be assessed.
- Prognostic cytogenetic markers [ Time Frame: Up to 5 years ]Potential prognostic markers will be assessed by polymerase chain reaction (PCR) to determine their prognostic value.
- Prognostic genetic markers [ Time Frame: Up to 5 years ]Potential prognostic markers will be assessed by polymerase chain reaction to determine their prognostic value.
|Estimated Enrollment:
|Actual Study Start Date:
|January 25, 2011
|Estimated Primary Completion Date:
|January 25, 2019 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment (chemotherapy and low-dose TBI before PBSCT)
CONDITIONING REGIMEN: Patients receive clofarabine IV over 2 hours on days -6 to -2. Patients also undergo TBI on day 0.
IMMUNOSUPPRESSION: Patients with related donors receive cyclosporine PO every 12 hours on days -3 to 56 with taper to day 180 and mycophenolate mofetil PO every 12 hours on days 0 to 28. Patients with unrelated donors receive cyclosporine PO every 12 hours on days -3 to 100 with taper to day 180 and mycophenolate mofetil PO every 8 hours on days 0 to 40 with taper to day 96.
TRANSPLANTATION: Patients undergo allogeneic PBSCT on day 0.
Procedure: Allogeneic Hematopoietic Stem Cell Transplantation
Undergo allogeneic hematopoietic PBSCT
Other Names:Drug: Clofarabine
Given IV
Other Names:Drug: Cyclosporine
Given PO
Other Names:Other: Laboratory Biomarker Analysis
Correlative studiesDrug: Mycophenolate Mofetil
Given PO
Other Names:Procedure: Peripheral Blood Stem Cell Transplantation
Undergo allogeneic hematopoietic PBSCT
Other Names:Other: Pharmacological Study
Optional correlative studiesRadiation: Total-Body Irradiation
Undergo TBI
Other Names:
Detailed Description:
I. To determine the maximum tolerated dose of clofarabine in combination with 2, 3, or 4 Gy TBI in preparation for hematopoietic cell transplantation (HCT) from human leukocyte antigen (HLA)-identical related and HLA-matched unrelated donors in patients with AML. (Part 1)
II. To determine the efficacy of the maximum tolerated dose of clofarabine combined with 2, 3, or 4 Gy TBI in reducing the 6 month relapse rate in patients with AML compared to our historical experience with fludarabine and 2 Gy TBI. A satisfactory improvement will be considered 6 month relapse rate declines from 35% to 20% among high-risk (objective for low risk group terminated August 2014). (Part 2)
I. Leukemia-free and overall survivals.
II. Non-relapse mortality (NRM) of < 5% at 100 days.
III. Engraftment rate of >= 95%.
IV. Prognostic significance of cytogenetics and genetic markers not detected by traditional karyotype analysis, with special respect to tyrosine kinase receptor mutations (such as fms-like tyrosine kinase 3 [FLT3]), retrovirus-associated deoxyribonucleic acid (DNA) sequences (RAS)- and nucleophosmin gene mutations along with CCAAT/enhancer binding protein, alpha (C/EBP) mutations.
V. Rigorous monitoring for minimal residual/recurring disease by standard morphologic, flow cytometric, and molecular techniques in order to facilitate early intervention.
VI. To evaluate the pharmacokinetics of clofarabine (pharmacokinetic samples discontinued January 2017).
OUTLINE: This is a dose-escalation study of clofarabine.
CONDITIONING REGIMEN: Patients receive clofarabine intravenously (IV) over 2 hours on days -6 to -2. Patients also undergo TBI on day 0.
IMMUNOSUPPRESSION: Patients with related donors receive cyclosporine orally (PO) every 12 hours on days -3 to 56 with taper to day 180 and mycophenolate mofetil PO every 12 hours on days 0 to 28. Patients with unrelated donors receive cyclosporine PO every 12 hours on days -3 to 100 with taper to day 180 and mycophenolate mofetil PO every 8 hours on days 0 to 40 with taper to day 96.
TRANSPLANTATION: Patients undergo allogeneic PBSCT on day 0.
After completion of study treatment, patients are followed up at 4 months and then every year thereafter.
|Ages Eligible for Study:
|2 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients age >= 55 years with AML OR patients age < 55 years with AML, who also through pre-existing medical conditions or prior therapy are considered to be at high risk for serious toxicities associated with a conventional, high-dose preparative regimen
- Patients must be in morphologic leukemia-free state (marrow blasts < 5%) without evidence of extramedullary disease within 21 days of HCT
- Only patients with Relapse Risk Score > 0 ("high risk") will be enrolled during Part 1; patients with all Relapse Risk Scores will be enrolled during Part 2 (low risk group terminated August 2014)
- HLA-identical related or HLA-matched unrelated donor available
- A signed informed consent form or minor assent form
- DONOR: FHCRC matching allowed will be grade 1.0 to 2.1: unrelated donors who are prospectively: matched for HLA-A, B, C, DRB1 and DQB1 by high resolution typing; only a single allele disparity will be allowed for HLA-A, B, or C as defined by high resolution typing
- DONOR: A positive anti-donor cytotoxic crossmatch is an absolute donor exclusion; donors are excluded when preexisting immunoreactivity is identified that would jeopardize donor hematopoietic cell engraftment; this determination is based on the standard practice of the individual institution; the recommended procedure for patients with 10 of 10 HLA allele level (phenotypic) match is to obtain a panel reactive antibody (PRA) screens to class I and class II antigens for all patients before HCT; if the PRA shows > 10% activity, then flow cytometric or B and T cell cytotoxic cross matches should be obtained; the donor should be excluded if any of the cytotoxic cross match assays are positive; for those patients with an HLA Class I allele mismatch, flow cytometric or B and T cell cytotoxic cross matches should be obtained regardless of the PRA results
- DONOR: Patient and donor pairs homozygous at a mismatched allele are considered a two-allele mismatch, i.e., the patient is A*0101 and the donor is A*0102, and this type of mismatch is not allowed
- DONOR: Peripheral blood stem cells (PBSC) only will be permitted as a HSC source on this protocol
Exclusion Criteria:
- AML French-American-British (FAB) M3 in first complete remission (CR1)
- Active AML involvement of the central nervous system (CNS) with disease refractory to intrathecal chemotherapy
- Presence of circulating leukemic blasts in the peripheral blood detected by standard morphology
- Patients who are human immunodeficiency virus (HIV)+ (HIV+ patients registered at Fred Hutchinson Cancer Research Center [FHCRC] should be offered treatment on Protocol 1410)
- Fertile men and women unwilling to use contraceptive techniques during and for 12 months following treatment
- Left ventricular ejection fraction < 35% (or, if unable to obtain ejection fraction, shortening fraction of < 26%); ejection fraction is required if age > 50 years or there is a history of anthracycline exposure or history of cardiac disease; patients with a shortening fraction < 26% may be enrolled if approved by a cardiologist
- Diffusion capacity of the lung for carbon monoxide (DLCO) < 40% (corrected), total lung capacity (TLC) < 40%, forced expiratory volume in one second (FEV1) < 40% and/or receiving supplementary continuous oxygen
- The FHCRC principal investigator (PI) of the study must approve enrollment of all patients with pulmonary nodules
- Patients with clinical or laboratory evidence of liver disease will be evaluated for the cause of liver disease, its clinical severity in terms of liver function, and the degree of portal hypertension; patients will be excluded if they are found to have fulminant liver failure, cirrhosis of the liver with evidence of portal hypertension, alcoholic hepatitis, esophageal varices, a history of bleeding esophageal varices, hepatic encephalopathy, uncorrectable hepatic synthetic dysfunction evinced by prolongation of the prothrombin time, ascites related to portal hypertension, bridging fibrosis, bacterial or fungal liver abscess, biliary obstruction, chronic viral hepatitis with total serum bilirubin > 3 mg/dL, or symptomatic biliary disease
- Serum creatinine should be within normal limits as specified by institutional guidelines; for patients with serum creatinine > upper limit of normal, a 24-hour creatinine clearance will be performed and should be equal to or more than the lower limit of normal
- Karnofsky score < 60 or Lansky score < 50
- Patients with poorly controlled hypertension and on multiple antihypertensives
- Females who are pregnant or breastfeeding
- Patients with active non-hematologic malignancies (except non-melanoma skin cancers) or those with non-hematologic malignancies (except non-melanoma skin cancers) who have been rendered with no evidence of disease, but have a greater than 20% chance of having disease recurrence within five years; this exclusion does not apply to patients with non-hematologic malignancies that do not require therapy
- The addition of cytotoxic agents for "cytoreduction" with the exception of tyrosine kinase inhibitors (such as imatinib mesylate), cytokine therapy, hydroxyurea, low dose cytarabine, chlorambucil, or Rituxan will not be allowed within three weeks of the initiation of conditioning
- Fungal infections with radiological progression after receipt of amphotericin B or active triazole for greater than 1 month
- Patients with active bacterial or fungal infections unresponsive to medical therapy
- DONOR: Marrow donors
- DONOR: Donors who are HIV-positive and/or medical conditions that would result in increased risk to the donor filgrastim (G-CSF) mobilization and PBSC collections
- DONOR: Identical twin
- DONOR: Any contraindication to the administration of subcutaneous G-CSF at a dose of 16 mg/kg/day for 5 consecutive days
- DONOR: Serious medical or psychological illness
- DONOR: Pregnant or lactating females
- DONOR: Prior malignancy within the preceding 5 years, with the exception of non-melanoma skin cancers
- DONOR: Children < 12 years old
Please refer to this study by its ClinicalTrials.gov identifier: NCT01252667
|United States, Colorado
|University of Colorado Cancer Center - Anschutz Cancer Pavilion
|Aurora, Colorado, United States, 80045
|United States, Louisiana
|Ochsner Medical Center Jefferson
|New Orleans, Louisiana, United States, 70121
|United States, Washington
|VA Puget Sound Health Care System
|Seattle, Washington, United States, 98101
|Contact: Thomas R. Chauncey 206-762-1010 firstname.lastname@example.com
|Principal Investigator: Thomas R. Chauncey
|Fred Hutch/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Contact: Brenda M. Sandmaier 206-667-4961 email@example.com
|Principal Investigator: Brenda M. Sandmaier
|Principal Investigator:
|Brenda Sandmaier
|Fred Hutch/University of Washington Cancer Consortium
|Responsible Party:
|Fred Hutchinson Cancer Research Center
|ClinicalTrials.gov Identifier:
|NCT01252667 History of Changes
|Other Study ID Numbers:
NCI-2010-02247 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
2430.00 ( Other Identifier: Fred Hutch/University of Washington Cancer Consortium )
P01CA078902 ( U.S. NIH Grant/Contract )
P30CA015704 ( U.S. NIH Grant/Contract )
|Study First Received:
|November 29, 2010
|Last Updated:
|July 12, 2017
Additional relevant MeSH terms:
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Neoplasms by Histologic Type
Mycophenolic Acid
Mycophenolate mofetil
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antifungal Agents
Anti-Infective Agents
Dermatologic Agents
Antirheumatic Agents
Calcineurin Inhibitors
Antibiotics, Antineoplastic
Antineoplastic Agents
Antimetabolites, Antineoplastic
ClinicalTrials.gov processed this record on September 21, 2017


text:
EDIT(Since comments keep coming to me in one way or another not understanding my article, I must point out, this article is not AGAINST "EDGY" WWE content, it is only trying to prove the point that those who say we need a new Attitude Era need to realize we are already in a non PG era. Please take that into consideration before PM'ing me that I am against new edgy content. Thank you.
Updated 02-04-2013 at 09:56 AM by Cyrus224
© 2011 eWrestlingNews, All Rights Reserved.


text:
Topic: New treatment on the horizon...i think!
I read this story on msnbc.com
http://www.msnbc.msn.com/id/31512315/ns … ns_health/
about a new treatment for breast cancer based on BRAC1 and BRAC2 pathways. These pathways are part of the problem with abnormal cells. Well, the new treatment targets these pathways and helps cure breast cancer. The drug is classified as a PARP inhibitor. There are several trials for other cancers and it is very successful.
GREAT news because a google search made me find out we are BRAC2 related!!!! I talked to my bestfriend the oncologist about this and apparently her rare cancer she specialises in is also BRAC2 and she said that from what she gathers from conferences, these new therapies are very good and are being sped through the trial and FDAapproval process.
After being bitter about all the money that breast cancer gets for research compared to us, I am finally smiling. Their research is going to benefit us! Lets hope it transfers to cc anyway and that it comes to fruition for many of us to benefit.
****I am still sick of feeling like the bastard step child in cancer research. and I still hate the lack of funding, research, and awareness of our cancer, but I am relieved to know that the research done for the glamour cancers can benefit us!
36 year old patient with buckets of hope


text:
Just the other day, I had an enlightening and refreshing eureka moment. I've been troubled for a while now with the disparity between property market conditions and agent feedback on activity and sales. In a nutshell, never the twain shall meet. Let me explain.
In my home town, I keep coming across the same agent – time and time again, both personally and via anecdotal evidence from family and friends. No names no pack drill, but it doesn't surprise me to learn that the agent concerned is slaying the opposition with demonstrably greater sales volumes.
So, when he tells me that it's a tough market but he's doing really well – I believe him.
But more importantly, and here's my point, not for him the same old agent speak (as I like to call it) of sunny blue skies. No – more like professionalism sprinkled with a healthy dose of realism.
And that's the difference – talk is cheap, but when you hear first-hand an acceptance that the market is tough, but houses are still selling, you realise that some agents at least have mastered their art. Indeed, others will tell you how busy they are, whilst eking out a living. Meanwhile, the best performing top agents bounce along like the proverbial Tigger.
So, coming full circle to my original statement, I've discovered that some agents really are doing well and therefore bucking the trend – as opposed to talking the talk. Therefore, for me to broad brush a picture of so called property market doom and gloom does not tell the full story. My eureka moment, if you like, was the realisation that the best performing agents have adapted to market conditions – and are therefore making some hay as and when the sun shines.
Further, I believe there are similarities between estate agent offices and sports teams. The successful ones are well run, focussed and include leaders in the mix.
With the Bank of England recently downgrading the 2013 UK economy growth forecast, general market conditions and sentiment are still some way off triggering a property market rebound.
So, the next time an agent tells you how busy there are, take a deep breath and conjure up a healthy dose of salt. But, remind yourself, that like most life experiences, there are winners and losers along the way. There are some agents that really are busy, but more importantly, they consistently sell property at a rate of knots.
Therefore, should it become necessary, resolve yourself to seek out and work with an agent that can get the job done.


text:
BOTH Paperstation Malvern Table Tennis League handicap finals produced exciting matches with both games only settled in the final sets.
In the main competition, the all-Division One clash was won by CSSC Ramblers over Pterodactyls Old Boys by just six points.
Chris Hewitt was in fine form for Ramblers and only dropped three sets with two against Dave White and one to league singles champion Wayne Chopping.
Hewitt was supported by Alan Salisbury, who shared his four sets with White and Chopping, while Graham Thompson also took a set.
The last match between Hewitt and Chopping proved decisive with the former winning on aggregate 42-33 to narrowly overturn the 23-point handicap.
In the secondary final, Division One side Ledbury Lions overturned an 86-point handicap against Division Two champions Manor Park Travellers to win by eight.
It was largely thanks to a solid performance by Patryk Kovacz, who won 11 of his 12 sets and combined with Steve Meredith to take three of the four doubles sets against Toby Wren and Martin Snee.
Wren played well for Travellers, winning his four sets against Meredith and claiming sets off both Kovacz and Richard Smith.
Snee took three sets off Meredith and one off Smith but lost the decisive final set 11-7 to Meredith which turned the match for Lions.
In the main competition semi-finals, Pterodactyls overcame a 162-point handicap to defeat Division Two side Nomads by 21 points.
They only dropped four sets to Nomads' Dave Hayes, two against Ian Bell and one each to Graham Collier and Steve Glazzard.
In the other last four clash between Ramblers and Manor Park Express, Hewitt, Thompson and Salisbury were in sparkling form.
They defeated Express by 109 points, only dropping six sets over the match.
Hewitt and Thompson clawed back 78 and 55 respectively to easily overcome the 79-point handicap.
Dave Woodyatt, with three sets, and Dale Dickinson (2) enjoyed success in reply for Express.
RESULTS Handicap main final: CSSC Ramblers 377 Pterodactyls Old Boys 371 (23); semi-finals: Nomads 424 (162) Pterodactyls Old Boys 445; Manor Park Express 312 (79) CSSC Ramblers 421.
Secondary final: Ledbury Lions 392 Manor Park Travellers 384 (86).


text:
Financial woes continue to stalk Willits Unified School District. At the March 6 meeting of the district's board of trustees, Interim Superintendent Debra Pearson will inform the board that initial estimates of Average Daily Attendance were optimistic, meaning ADA revenues are lower than anticipated.
Pearson will also inform the board the federal sequestration that went into effect March 1, will result in an additional loss to the district of $65,000 in the 2013-2014 school year, if the situation remains unchanged.
The district continues to be under the watchful eye of the state Office of Education. In a memo released March 4, State Superintendent Tom Torlakson named WUSD, along with 123 other local educational agencies, as being at risk financially.
The district was placed in "qualified certification" status for the fourth consecutive reporting period. A qualified status suggests WUSD "may not meet its financial obligations for the current or two subsequent fiscal years". The certification allows the Mendocino County Office of Education to provide assistance to the district.
Interim Superintendent Debra Pearson outlined the situation.
"We have been required [by the county] to prepare a third interim report," she said.
The district has been working closely with the Mendocino County Office of Education to return the district to solvency by the 2014-2015 school year.
Under the direction of the MCOE, the district has already outlined $750,000 in budget cuts for the 2013-2014 school year. Those cuts?which include layoffs of teachers and classified staff?are set to be formally approved at tonight's meeting.
District officials will present the second interim report at the meeting.
"What we're really looking at now is a current time snapshot," Pearson said.
The board will use that snapshot to assess the planned cuts and start the difficult task of cutting another $750,000 for the 2014-2015 school year.
The California Department of Education monitors the financial health of the state's 1,043 local educational agencies via a Notice of Interim Certifications twice a year.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
Instead of calling it a case of biting the hand that feeds you, lets say it is a case of biting the group that has helped you.
Five or six years ago, Hope for Pets was a very vocal group of people who wanted to see improvements in the Bullitt County Animal Shelter.
Their efforts may have played a part in getting improvements made and their enthusiasm may have played a small part in deciding an election four years ago.
If you currently subscribe or have subscribed in the past to the The Pioneer News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning The Pioneer News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
'Philadelphia would be the team to score early in the third as Kimmo Timonen ripped a shot from the point on the power play to take the 5-4 lead. The score stayed the same until the final seconds when Ales Kotalik won the draw in the Flyers zone and Jochen Hecht smashed a one timer from the face off circle that Thomas Vanek tipped in to tie the game with just eight seconds left in regulation.'
You are here: Home / SabresBeat / Wild Night In Philly; Sabres Complete Comeback


text:
A KNUTSFORD teenager has enjoyed a royal date.
Jack Kimber, of Northfields, was among hundreds of young achievers from across the UK invited to St James' Palace.
Jack, 17, attended North Cestrian Grammar School in Altrincham, where he achieved their Gold Duke of Edinburgh's Award.
He attended the ceremony at the palace to receive his certificate from the award scheme's patron and founder, The Earl of Wessex.
He completed his gold Duke of Edinburgh programme over 20 months, finishing in 2012, making him one of the youngest recipients at the school.
The activities included deer stalking, achieving a Black Belt in Taekwondo, learning the drums, providing voluntary support for a junior church at St John's, Knutsford and expeditions to Hadrian's Wall, the Lake District and the Brecon Beacons.
Jack said: "While it was often very hard work and tiring, it has taught me a huge amount in many areas of my life which I think will have set me up really well for the future.
"I look back with great pride that I stuck with it, even when it was really tough."


text:
Advanced information technology is changing the way professionals lead. Penn State Great Valley's master of leadership development program addresses this concern as part of its annual Leadership in Action series. "Leading in the Digital Age: Are You Connected for Success?" will be held from 5:30 to 8 p.m., Wednesday, March 26, in Musser Auditorium, The Conference Center, 30 E. Swedesford Road, Malvern, Pa.
The event will feature an expert panel presenting their cutting-edge research and best practices for harnessing technologies to develop leadership behaviors linked to individual, team and organizational performance. Discussions will include how students and alumni of the leadership development program have used these practices to promote positive change in their organizations and lives. Light refreshments will be served. This is a free event, but preregistration is recommended. Visit http://www.sgps.psu.edu/LIA2014/default.ashx.


text:
COMMUTERS are facing chaos after thunder and lightning storms.
Hundreds of bolts of lightning lit the night sky last night in Essex with two storms in the early hours of this morning.
Greater Anglia has severe problems on the lines and it will continue throughout the day with some services cancelled this afternoon due to hot weather.
An electrical storm has caused a signalling fault in the Romford area causing delays.
A signalling and points fault at London Liverpool Street is preventing access to and from platforms seven to ten. Train services on all Greater Anglia routes into London are affected by this problem.
A signalling problem at Ingatestone affecting the level crossing is affecting mainline train services to and from Colchester, Clacton, Ipswich, Norwich, Harwich Town and Braintree. Customers holding advance purchase tickets may travel on alternative trains, if your designated service is cancelled.
First Capital Connect, TFL buses, London Undergound and c2c will accept valid Greater Anglia tickets on any reasonable routes.
A spokesperson for Greater Anglia said: "We are sorry travel plans will be severely affected by this widespread disruption and thank you for your patience whilst Network Rail engineers resolve the problems."
West Anglia routes serving Stansted Airport, Bishop's Stortford and Cambridge are also affected.
Disruptions are due to continue through the afternoon as Network Rail puts in place speed restrictions between 1pm and 8.30pm due to the predicted hot weather.
The mercury is expected to rise to 31C this afternoon.
It means train services operating between Liverpool Street and Colchester, Norwich and Southend Victoria will be subject to some alterations and cancellations. Customers travelling during this time are advised to check for travel updates on the Greater Anglia website.
A full list of changes expected at this time are below.
Meanwhile the c2c route is running as normal apart from minor three minute delays for passengers travelling through Chalkwell station as there are speed restrictions in place due to a fault with the insecure footbridge.
First buses have warned Basildon passengers to expect delays due to surface water on roads.
The following amendments to train services will apply today:
15:52, 19:52 Ipswich to Liverpool Street
15:58 Ingatestone to Colchester
16:17, 16:47, 17:12 Liverpool Street to Witham
16:30 Southend Victoria to Liverpool Street
16:53 Colchester to Liverpool Street
17:45, 18:05 Liverpool Street to Southend Victoria
18:16 Witham to Liverpool Street
18:18, 18:38 Liverpool Street to Ipswich
20:22 Ipswich to Colchester
15:38 Liverpool Street to Colchester Town calls additionally at Ingatestone and Hatfield Peverel
16:32 Liverpool Street to Ipswich calls additionally at Ingatestone
17:09 Liverpool Street to Clacton calls additionally at Ingatestone
17:20 Liverpool Street to Braintree calls additionally at Hatfield Peverel
17:32 & 19:18 Liverpool Street to Clacton services start from Colchester
17:38 Liverpool Street to Ipswich calls additionally at Marks Tey
18:02 Liverpool Street to Southminster will call additionally at Billericay.
18:12 Colchester to Liverpool Street calls additionally at Ingatestone
18:48 Liverpool Street to Clacton calls additionally at Ingatestone and Marks Tey
19:32 Liverpool Street to Harwich International calls additionally at Ingatestone
20:05 Clacton to Liverpool Street calls additionally at Marks Tey, Kelvedon and Hatfield Peverel


text:
15 U.S. Code § 3204 - Special rules for standards
§ 3204.
Special rules for standards
(a) Procedures for termination of gas serviceThe procedures for termination of service referred to in section 3203(b)(1) of this title are procedures prescribed by the State regulatory authority (with respect to gas utilities for which it has ratemaking authority) or the nonregulated gas utility which provide that—
no gas service to a gas consumer may be terminated unless reasonable prior notice (including notice of rights and remedies) is given to such consumer and such consumer has a reasonable opportunity to dispute the reasons for such termination, and
(2) during any period when termination of service to a gas consumer would be especially dangerous to health, as determined by the State regulatory authority (with respect to each gas utility for which it has ratemaking authority) or nonregulated gas utility, and such consumer establishes that—
he is unable to pay for such service in accordance with the requirements of the utility's billing, or
such service may not be terminated.
Such procedures shall take into account the need to include reasonable provisions for elderly and handicapped consumers.
(b) Advertising
(1) For purposes of this section and section 3203 of this title—
The term "advertising" means the commercial use, by a gas utility, of any media, including newspaper, printed matter, radio, and television, in order to transmit a message to a substantial number of members of the public or to such utility's gas consumers.
The term "political advertising" means any advertising for the purpose of influencing public opinion with respect to legislative, administrative, or electoral matters, or with respect to any controversial issue of public importance.
(2) For purposes of this section and section 3203 of this title, the terms "political advertising" and "promotional advertising" do not include—
advertising which informs natural gas consumers how they can conserve natural gas or can reduce peak demand for natural gas,
advertising required by law or regulation, including advertising required under part 1 of title II of the National Energy Conservation Policy Act [42 U.S.C. 8211 et seq.],
(Pub. L. 95–617, title III, § 304, Nov. 9, 1978, 92 Stat. 3151.)
References in Text
The National Energy Conservation Policy Act, referred to in subsec. (b)(2)(B), is Pub. L. 95–619, Nov. 9, 1978, 92 Stat. 3208. Part 1 of title II of the National Energy Conservation Policy Act was classified generally to part A (§ 8211 et seq.) of subchapter II of chapter 91 of Title 42, The Public Health and Welfare, and was omitted from the Code pursuant to section 8229 of Title 42 which terminated authority under that part June 30, 1989. For complete classification of this Act to the Code, see Short Title note set out under section 8201 of Title 42 and Tables.
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


text:
U.S. Establishes Full-time Aviation Detachment in Poland
By Jim Garamone
American Forces Press Service
WASHINGTON, Nov. 9, 2012 – U.S. officials praised the long-standing relationship with Poland as they celebrated the first full-time U.S. military presence in that nation today.
During a ceremony at Lask Air Base, located about 100 miles southwest of Warsaw, U.S. Air Force personnel flew the American flag, marking the establishment of a small unit dedicated to supporting multi-national aviation training and exercises. The ten personnel of the detachment will be joined by up to 200 visiting airmen conducting quarterly training rotations.
U.S. Ambassador to Poland Stephen D. Mull and Navy Adm. James G. Stavridis, the commander of U.S. European Command and NATO's supreme allied commander, were joined at the ceremony by Poland's Defense Minister Tomasz Siemoniak, Chief of Staff Army Gen. Mieczyslaw Cieniuch and Air Force Commander Gen. Lech Majewski.
The arrival of the 10-man team at the base represents "a new kind of U.S. 'boots on the ground' here in Poland," said Derek Chollet, the assistant secretary of defense for international security affairs. Chollet represented Defense Secretary Leon E. Panetta at the ceremony.
"The alliance between the United States and Poland is rooted in shared history, shared values and deep ties among our people, cemented through NATO and the ironclad commitment to Article 5," Chollet said. "The Polish people have been our partners for over two centuries, and since joining the NATO alliance in 1999, your troops have been shoulder-to-shoulder with ours in the Balkans, in Iraq and in Afghanistan."
The personnel in Lask will provide continuity for U.S. personnel rotating in and out of Poland, defense officials said. Air Force F-16 Fighting Falcon and C-130 Hercules units will form the core of the U.S. presence. The personnel at the detachment will report to the 52nd Fighter Wing, based at Spangdahlem Air Base, Germany.
President Barack Obama and Polish Prime Minister Donald Tusk agreed to the U.S. presence in Lask during the president's visit to Poland last year. The detachment will make it easier for U.S. and Polish airmen to increase their interoperability and will enhance military-to-military ties at all levels, defense officials said.
The presence will also facilitate bilateral and, officials hope, multinational joint training exercises. Poland has extensive ranges and its airspace is far more open than countries farther west. Officials also hope this will allow both militaries to deepen already strong partnerships.
"I am truly proud of the way our defense cooperation has focused on looking to the future to ensure we are prepared for the threats and challenges our countries will face," Chollet said. "As we move together into the future, we expect more U.S. boots to follow as we establish a NATO ballistic missile interceptor site at Redzikowo in 2018."
The U.S. aviation detachment "also sends a clear message to allies and partners that the U.S. remains committed to European defense and to the principle that we are indeed 'stronger together,'" Chollet said.
|Join the GlobalSecurity.org mailing list


text:
We often plough so much energy into the big picture, we forget the pixels. --Silvia Cartwright
It seems fitting that as 2012 comes to a close, the only thing that really matters is the fiscal-cliff debate. Since the market low in 2009, the biggest change in the market action has been that stocks are highly correlated and we are much more reactive to macroeconomic news. Individual stock picking has taken a backseat to predicting what government officials will do next.
The current fiscal-cliff debate is a great example of this tendency. It doesn't much matter what stocks you pick right now. The key is to make sure you are on the right side of the headlines out of Washington. If you have a great stock pick but the news is bad, you are still going to have difficult time making money.
I'm sure there are traders who enjoy the volatility created by the macro headlines. It requires a particular mindset and it is necessary to employ a strategy that is focused mainly on overall market direction rather than individual stock selection.
My focus has always been on individual stock picking, so I find the focus on macro news to be quite frustrating at times. There are still stocks that buck the trend but even those often trade in a choppier fashion and are more susceptible to headline news.
What has probably made this tendency to react to news headlines even worse is the continued exodus of individual traders from the markets. Brokers and mutual funds have seen declining assets for years now which means the market is controlled more and more by large hedge funds and computerized trading, which employ strategizes that make individual stock picking seem like a quaint strategy employed by the naïve and uninformed.
I can complain at great length about how central bankers and politicians have screwed up the way the market operates, but our job as traders isn't to be nostalgic but to adapt and find ways to deal with the new conditions. Obviously, we have to spend much more time now trying to predict what will be the next major governmental news to move us. That means we have no choice but to obsess over this fiscal cliff debate like everyone else. It is the only news that matters and will determine the direction of the vast majority of stocks in the market.
I believe that we will have a fiscal cliff deal very soon, but if there aren't concrete signs of further progress by Friday, the market will become nervous and sell off. We had some nerves set in yesterday, after a terse comment by Speaker Boehner and name calling by various politicians. We should have a number of headlines during the day today and then market players are going to be very anxious to take a break and enjoy the holidays.
My game plan has been to try to focus on individual trades. I've had some success with names I've mentioned in the blog, but it has been very hard to put much money to work since conditions are so unstable due to the headline reactions. I'm going to continue to try to pick off some trades and look to be more aggressive when the fiscal-cliff uncertainty finally declines.
Early indications are for another mildly positive start. Traders are already starting to wind down for the holidays and the action is slower, but any major fiscal-cliff news is going to move this market very fast.


text:
Red Carpet Inn - Unadilla
Unadilla, GA 31091
Just off I-75, ½ mile from horse show arena. Convenient to Perry Fairgrounds, Andersonville Trail & Camellia Gardens, and agricultural center. Guests enjoy premium movie channels, free coffee & free local calls. Ample truck parking available.
Info & Amenities
Hours of Operation
Sunday: All Day
Monday: All Day
Tuesday: All Day
Wednesday: All Day
Thursday: All Day
Friday: All Day
Saturday: All Day
AARP, Military Discount
Facility Amenities
Free Local Calls, Free Parking
Near Interstate Highway
Room Information
Number of Rooms (Total): 60


text:
Volvo 740 Problems
RepairPal has identified the most common problems with the Volvo 740 based on complaints from actual vehicle owners. We'll tell you what the problem is and what it'll take to fix it.
Transmission oil leakage from the rear output seal is common, caused by a worn output shaft bushing. Our technicians tell us both parts should be replaced to correct this concern.
A faulty RPM sensor can cause the Check Engine Light to come on and cause a "No Start" condition.
The fuel pump relay may fail resulting in a "no start" condition, the engine will crank over but will not start and run. Checking for proper fuel pressure would be the first step in diagnosing this concern.
Engine stalling/stumbling problems can be caused by a failing mass airflow sensor.
When braking, a loose feeling from the front end can be caused by worn strut rod bushings. Worn bushings will require replacement. After they are replaced the wheel alignment should be checked.
A rattling noise from under the vehicle can be caused by a loose exhaust header pipe heat shield. Properly securing the shield should correct this concern.


text:
Grassroots is key, says former Arsenal and England captain Tony Adams
2:40pm Tuesday 7th January 2014
By Hayley Mortimer
2:40pm Tuesday 7th January 2014
By Hayley Mortimer
FORMER England and Arsenal captain Tony Adams fears for the future of the national team unless steps are taken to give more support to grassroots football.
Adams, who won 66 international caps, believes investing in grassroots will increase the chances of unearthing the next generation of top English players.
His comments came at the launch of Inside Football - an indoor 3G football pitch at Brimscombe Port - on Friday, December 3.
He questioned why fewer English youngsters are breaking through into the country's top teams and stressed the importance of facilities like Inside Football.
"These indoor facilities are so needed," said Adams, who lives near Cirencester.
"If I had it my way I would put one in every borough in the country.
"More has to be done at grassroots level to encourage the next generation of English talent."
Following his hugely successful playing career, Adams has enjoyed stints in charge of Wycombe and Portsmouth and spent time coaching in Holland.
He continues to work with Gabala FC in Azerbaijan, the club he left as manager in 2011.
"As a country we are falling behind," he said.
"There is a reason only 24 per cent of English league players are British and there are only four English coaches in the Premier League.
"In Azerbaijan they are building facilities like this all over the country.
"In Holland the vision is that every child can cycle to an indoor football facility.
"Children need a safe environment to practise their skills."
Adams argued that not enough cash is trickling down to grassroots level.
"We have coaches on such poor money. It's not respected," he said.
"We need to change that mentality."
For more information about Inside Football see www.insidefootball.net
© Copyright 2001-2017 Newsquest Media Group