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Calibration Trends
McMillan and Weiner Ask Glenn Gardner, Fluke Product Planner, to Help Them Complete Their Perspective on Calibration by Taking a Look at Future Trends
Greg: An instrument is only as good as its calibration. Instruments have significantly improved, but are not perfect. Resources have dramatically declined. Mistakes can be made by the design engineer, vendor, manufacturer and the maintenance technician. Good calibration procedures and the leading tip "Always Ask Why" from 101 Tips for a Successful Automation Career can catch these mistakes.
Stan: Instruments are the only window into the process. Errors and incorrect ranges can result in inefficient and unsafe operation. We asked Glenn Gardner, Fluke product planner, to help complete our perspective on calibration by taking a look at future trends.
Greg: Stan and I enlisted the help of engineers who were proficient in the design, installation, checkout and start-up of electrical devices and got specialists to do the high-voltage stuff. We could focus on instrumentation. In the 1990s we saw the start of the decline of instrument engineers and technicians in the plants and the rise of groups for distributed control systems (DCS) and information technology (IT). Who is making sure the best instrument technology is used and maintained? Are the plant instrument engineer and technician becoming extinct?
Glenn: On the engineering side, the workload is often split between an instrument engineer responsible for the instrument management system, and a controls engineer who focuses on the DCS configuration and performance. On the technician side, workforce reductions have caused a trend towards hybrid "E&I" techs that maintain both automation and electrical systems, including drives and switchgear. Overall, the trend is towards generalism: Anyone working in automation is expected to understand the basics of asset management systems, data historians, DCS hardware and software, fieldbuses, power distribution, MCC's, networks, wireless, etc.
Stan: How are the technicians adapting?
Glenn: The instrument techs seem to be able to pick up how to support the electrical and power systems. Electrical techs are having a tougher time learning how to calibrate, configure and troubleshoot instrumentation systems.
Greg: I saw a disturbing trend where the emphasis was becoming more on moving data around than getting better data from better instrumentation and process control or better presentation and analysis of the data by better operator interfaces and data analytics. We ended up with deluge of data, and not knowing how good the data was or what the data meant. Some IT departments thought they should be responsible for the generation and use of data.
Glenn: The confusion seems to be lessening, with IT groups staying on the business technology (BT) side. It's noteworthy that the IT workforce tends to be fairly young, whereas the plant technician workforce in the USA and Europe is nearing retirement. I'm concerned about who will inherit the tribal knowledge required to maintain the plant systems. The inverse of this problem is present in emerging regions: There are plenty of young engineers and techs at process plants, but very few experienced mentors.
Stan: What are the trends in calibration practices from the decrease in resources and expertise?
Glenn: Spot checks (in-situ where possible) are used to make a one-point calibration. A zero adjustment is used to compensate for an offset between the transmitter output and a precision measurement at the transmitter (e.g., precision pressure gage near pressure sensor). A span adjustment requires the removal of the transmitter and a source to provide at least two operating values of the process variable measured.
Greg: The measurement errors seen in a control loop are more from offsets or zero shifts than from changes in span. Also, a zero adjustment can compensate for a span error for control at a setpoint. If there is poor control, the span error shows up as a change in process gain. Since there are much larger sources of nonlinearity, the span error is mostly a consideration when operating at vastly different setpoints. We take advantage of this understanding in pH measurements by taking a sample and using a lab meter at the pH measurement point to make an offset adjustment. To make span adjustments to account for changes in electrode efficiency would require removal of the electrodes and testing in buffer solutions, upsetting the equilibrium of the reference electrode.
Stan: How does this method fit in with a documenting calibrator?
Glenn: Spot check results and the criticality of the measurement are used to help determine when a full calibration should be done with a documenting calibrator.
Greg: What are the choices for a calibrating a temperature transmitter?
Glenn: We have three ways of doing temperature transmitter calibrations. First, we can use a thermocouple millivolt or RTD resistance source to calibrate the temperature transmitter output. Obviously, this does not test the accuracy or condition of the sensor. Second, we can pull out the sensor and insert it into a temperature bath and perform a full calibration. This method is much more common when the calibration is performed in the shop rather than the field. Third, some thermowells have a slot for the direct insertion of a reference probe that can be used to perform a single-point calibration in-situ.
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Re: LY2801653 clinical trial
End of cycle 3 and results are in... CA19-9 is NORMAL!! 35.7!! Weight is still climbing. Doc is happy! So am I! My new clothes are upset, but that's life.
No ct this round so have to wait another 4 weeks to find out, but everything points to stability and inactivity.
Onc gave me a prescription for my face and its better. I've been washing my hair with Selsun Blue and the scalp is better, too. Still have some pimply itchy things, but nothing like it was. I also went back to washing my hair almost every night. I have been trying to do every other day for the past 5 years, but I guess my new skin type says "CLEAN"!! So I will!
The swelling is better, too. Still swollen in morning... Enough to change the fingers of my rings, but after a couple of hours, they are back to normal.
I will take these minor discomforts any day!
"Don't just have minutes in the day; have moments in time."
Any opinions I give are based on personal experiences, and are not based on medical knowledge. I strongly suggest receiving medical care and opinions.

subset: commoncrawl


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Seville Michelle Anastos pieces inspire instantaneous awe when added to any streetwear look. The eponymous Seville Michelle Anastos is a native New Yorker who made the brave decision to launch her dream line in 2009. Today, the collection swells with celebrity style: from decadent epaulets, ornamental shoulder pieces, and Italian leather bangles, all the way to door knocker earrings, her pieces have caught the attention of style icons and fashion-forward thinkers everywhere. The designer's defined style proudly boasts uncompromising quality and a sophistication that sits within the details.
No products match your selections. Try clearing your filters.


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The PharmaSea project focuses on biodiscovery research and the development and commercialisation of new bioactive compounds from marine organisms, including deep-sea sponges and bacteria, to evaluate their potential as novel drug leads or ingredients for nutrition or cosmetic applications. The international team of scientists is led by Professor Marcel Jaspars of the University of Aberdeen in Scotland, and coordinated by Dr. Camila Esguerra of the University of Leuven in Belgium.
One of the aims of PharmaSea is to discover new marine bacteria that can produce novel antibiotics: "There's a real lack of good antibiotics in development at the moment. There hasn't been a completely new antibiotic registered since 2003. If nothing's done to combat this problem we're going to be back to a 'pre-antibiotic-era' in around ten or twenty years, where bugs and infections that are currently quite simple to treat could be fatal", says Marcel Jaspars, who is Professor of Chemistry and Director of the Marine Biodiscovery Centre at the University of Aberdeen. PharmaSea will also focus on drug discovery for neurological, inflammatory, and other infectious diseases.
Only a handful of samples have ever been taken from deep trenches and investigated, so the project is breaking new ground. "PharmaSea will not only be exploring new territory at the bottom of the oceans, but also new areas in 'chemical space'. With our broad platform of cutting-edge bioassays to detect drug-like activity, we'll be testing many unique chemical compounds from these marine samples that have literally never seen the light of day. We're quite hopeful that we'll find a number of exciting new drug leads", says Dr. Camila Esguerra, Industrial Research Fellow and Lecturer with the Laboratory for Molecular Biodiscovery at the University of Leuven,
The international team will employ strategies commonly used in the salvage industry to carry out the sampling. Using fishing vessels, researchers will drop a sampler on a reel of cables to the trench bed to collect sediment. Scientists will then attempt to grow unique bacteria and fungi from the sediment that can be extracted to isolate novel drug-like molecules for pharmacological testing. Partners from China, Chile, Costa Rica, New Zealand and South Africa will support the PharmaSea project. The first field tests will be carried out next autumn in the Atacama Trench in the Eastern Pacific Ocean, about 100 miles off the coast of Chile and Peru. The team will also search the Arctic waters off Norway and the Antarctic via Italian and South African partners. Deep trenches will also be accessed off New Zealand and China.
Marine organisms that live more than 2,000 meters below the sea level are considered to be an interesting source of novel bioactive compounds as they survive under extreme conditions. "Trenches are separated from each other and represent islands of diversity. They are not connected to each other and life has evolved differently in each one", explains Marcel Jaspars.
Further information: http://www.pharma-sea.eu
• University of Leuven (Belgium)
• The University of Aberdeen (UK)
• Aquapharm Biodiscovery Ltd (UK)
• University of Tromsø (Norway)
• eCoast Research Centre (Belgium)
• Biobridge Ltd (UK)
• Fundación MEDINA (Spain)
• University College Cork, National University of Ireland
• BIOCOM AG (Germany)
• Stazione Zoologica Anton Dohrn (Italy)
• Consiglio Nazionale delle Ricerche ibp-cnr (Italy)
• University of Santiago de Compostela (Spain)
• The Royal Society of Chemistry (UK)
• c-LEcta GmbH (Germany)
• Technical University of Denmark
• Deep Tek Ltd (UK)
• Advanced Chemistry Development UK Ltd
• Wuhan University (China)
• Institute of Microbiology – Chinese Academy of Sciences (China)
• University of the Western Cape (South Africa)
• Institute for Cell Dynamics and Biotechnology (Chile)
• National Biodiversity Institute of Costa Rica
• International Union for Conservation of Nature (Switzerland)
• University of Waikato (New Zealand)
1) Colourful sea squirt / Cold water Ascidiaceae, a Botryllus specie, Copyright: Kirsti Helland, Marbio, University of Tromsø, Norway
2) Arctic Collection in 2009 with Project Leader Marcel Jaspars
Copyright: Marcel Jaspars, University of Aberdeen
CONTACT Communication:
Annette Langbehn
Phone: +49 30 26492171
Email: press(at)pharma-sea.eu
Euan Wemyss
University of Aberdeen, King's College (Office of External Affairs)
Phone: +44 1224 272960
Email: e.wemyss(at)abdn.ac.uk
PharmaSea: http://www.pharma-sea.eu
Marcel Jaspars / University of Aberdeen: http://www.abdn.ac.uk/ncs/profiles/m.jaspars/
Camila Esguerra / KU Leuven:


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FIVE Black Country fraudsters have been jailed for their part in stealing more than £8 million from the taxpayer following a six-year investigation by HM Revenue and Customs.
They were part of a 20-strong gang from the West Midlands, Staffordshire and Manchester that "shamelessly" stole the cash over a two-year period through tax offences and money laundering linked to the construction industry.
Investigators uncovered a large and complex web of illegal activity involving more than 100 businesses. Subcontractors were employed 'off-record' and the gang members pocketed income tax and national insurance contributions due to be paid to HMRC.
Fake invoices, supposedly for providing labour, had also been created to claim VAT refunds, to which the gang were not entitled.
HMRC investigators carried out searches at more than 40 residential and business premises across the UK in September 2009.
They seized paperwork, computers, class A drugs and almost £170,000 in cash from 11 business properties in the West Midlands and Manchester.
Smaller quantities of US dollars and Euros were also discovered.
All defendants have now been sentenced following three separate trials at Birmingham Crown Court, the last finishing on Wednesday July 30, and reporting restrictions have been been removed.
Construction boss Bernard Harper, aged 58, of Causey Farm Road, Halesowen, was described by His Honour Judge Simon Carr as "the centre of the fraud and an organiser of it".
He was jailed for eight years and disqualified from acting as a company director for 10 years.
Anthony Smith, aged 36, of Mill Street, Brierley Hill, admitted cheating the revenue and was jailed for five years and one month.
Smith, a former bank manager, was described by the judge as Harper's "lieutenant and the office manager" when he was not present.
Kelly Nicholls, aged 36, of Mill Street, Brierley Hill, was jailed for five years for producing invoices and helping with administration tasks connected to the fraud.
Susan Coussens, aged 55, of Chestnut Close, Norton was found guilty of the same offence and jailed for four years.
Accountant Steven Jeremy Bache, aged 52, of Leys Close, Stourbridge, was found guilty of using his expertise to evade HMRC controls. He was jailed for three-and-a-half years and prohibited from acting as a company director for seven years.
Speaking after the final sentencing, Colin Booker, assistant director criminal investigation at HMRC, said: "This brings to an end a six-year investigation, centred on a highly organised and complex fraud, undertaken by a group of individuals who cared for nothing but their own financial gain.
"HMRC is investing more time and resources than ever into identifying fraud. Our work does not stop at sentencing, but at depriving those involved of the proceeds of their crimes.
"Confiscation action will follow, as we attempt to recoup some of the £8 million the gang so shamelessly stole from the taxpayer."


text: Obermeyer Chooses Suzuki Press Release | December 12, 2013 Off-road racer Nick Davis (above) and Obermeyer Yamaha in Indiana have agreed to a deal that will see Davis race the 2014 Kenda AMA National Enduro Series and the GNCC series aboard an Obermeyer Yamaha-backed Suzuki RM-Z450. Here is the press release in its entirety:Fueled by passion and enthusiasm, Keith Obermeyer of Obermeyer Suzuki in Jasper, Indiana and Nick Davis from Meshoppen, Pennsylvania, have formed Obermeyer Suzuki Off-Road Racing. The focus will be on winning championships, and will require using one of the most acclaimed bikes to conquer this task, the Suzuki RM-Z450!With the huge sales growth that Suzuki and its dealer network have experienced in the last year, it is no coincidence that more riders and racers are migrating to the RM-Z line of motorcycles to go off-roading.Keith Obermeyer states, "By using the 2014 Suzuki RM-Z Dealer Race Support Program to our advantage, we were able to use the RM-Z and Suzuki's focus on dealer-supported racing to fit our needs for this upcoming season. I have never seen this type of program from any manufacturer for grass roots support of dealer-backed racing! Suzuki is on the gas and we are looking forward to this season.""Josh Strang was the champion in 2010 on Suzuki and runner up in 2011 so we know the technology is champion approved, and has only improved since then. The guys in MX and SX have proven the potency of the RM-Z line with the likes of Davi Millsaps, James Stewart, and the RCH Suzuki Team."Obermeyer goes on to say, "The RM-Z is an amazing machine–smooth, strong power, great suspension package, and the best handling chassis available."As news about Suzuki having a strong presence in GNCC and National Enduro has been buzzing on the various web sites and blogs, there is a high level of excitement surrounding the upcoming season. The 19 year-old Nick Davis will have solid backing from Obermeyer Suzuki, coupled with support and resources from many of the top companies in the industry, to compete for the championship of the 2014 season. Obermeyer is honored to have continued support from: Fly Racing,FMF,GE Capital, Unabiker, Sunstar Sprockets and Chains, IMS Products, Enduro Engineering, Rekluse Clutches, as well as new sponsors: Stickman Graphics, Eleven Ten Mods, Suzuki Motor of America, Inc., Suzuki Genuine Parts and Accessories, Works Enduro Rider Suspension, NoToil Air Filters. By Press Release Comments


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McCormick Is Still Too Spicy
Last night on "Mad Money," Jim Cramer said spice maker McCormick & Co. (MKC) is a buy. After missing estimates two weeks ago, the shares were mercilessly pounded into the ground as investors ran for cover. The stock is still limping around looking to recover. I looked at the company last September and thought the shares were too spicy. Since then (and after the recent shellacking), the stock is up about $0.29. I'm not so certain there will be a big rebound in the stock any time soon.
On Jan. 24, McCormick's fourth quarter earnings missed the Street estimate by $0.03 and it lowered guidance for 2013. The company posted revenue growth of just 3.2% to $1.15 billion vs. the consensus of $1.17 billion. For 2013, management told investors to expect earnings per share in the $3.15 to $3.23 range vs. the previous estimate of $3.33. The company said first-quarter sales growth would be below the 5% rate investors were modeling, since comparisons with last year's results will be very difficult to beat. The stock sold off on the disappointing news....253 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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text: OverviewBack to top Solid Gold - Aloe Bi-Liniment For Horses And Dogs - 16 oz. Item# :115099UPC# :093766744042 Brand:Solid Gold Size/Form:16 oz. Ship Weight:3.50 Solid Gold Aloe Bi-Liniment For Horses And Dogs 16 oz. (473 ml) Solid Gold Aloe Bi-Liniment For Horses & Dogs contains yucca, jojoba, aloe vera, comfrey, fungicide and biotin. Solid Gold Aloe Bi-Liniment For Horses and Dogs is an all-natural liniment for muscles and joints. Want that extra shine on your pet? Solid Gold health and coat care products will give your pet the fur and coat you always wanted. From shampoo to coat conditioner, Solid Gold Pet Health Products has all the care products you need to get the most out of your pet. What is the shelf life of Solid Gold Dry Food?Solid Gold dry foods have a shelf life of one year. The bags are dated with a best before date which is exactly one year from the day of manufacture. Solid Gold recommends using the food within 3 months after opening. I have been feeding Solid Gold for years, but the last bag that I opened looked darker (or lighter) than before. Should I be concerned about feeding this to my pet?Since Solid Gold does not add artificial colors or flavors to the food, they expect to see slight variation from batch to batch. This is simply a reflection of the natural ingredients they use, and in no way affects the quality of the food. Are the fish used in your foods farmed or wild caught?Solid Gold only uses wild caught fish - their fish are never from fish farms. I have a small breed puppy, but I do not see a small breed puppy food. What should I feed him/her?Small Gold recommends feeding small breed puppies the Just A WEE BIT formula. It is specifically formulated for smaller breeds, which have a higher calorie requirement per pound of body weight than larger dogs and the nutrient profile closely matches that of the Hundchen Flocken puppy formula. This, it is suitable for puppies and adults alike. My dog likes to eat the cat stool out of the litter box. Can I give the SEP to my cat to prevent this?You cannot give SEP to cats as they cannot handle the excess glutamic acid, which is the bittering agent in this product. Because of their diet, cats produce a very palatable stool, as they are often eating a higher protein food than dogs are and some of this passes undigested in the stool. Unfortunately, Solid Gold is unaware of any product which can be given to the cats to prevent this issue. The best recommendation they have is a covered litter box, or one that allows for top entry, and is this inaccessible to dogs. What is the best way to store Solid Gold pet food once it is opened?Solid Gold generally recommends placing the entire bag into an airtight container, without pouring it out. The container should be stored in a cool, dry place. Pouring the food out exposes it to a rush of air and can increase the rate at which it will oxidize, decreasing the shelf-life. By leaving the food in the bag and then placing the bag into an airtight container, the bag becomes a barrier which then provides an extra layer of protection. Also, this allows tracking of any issues or problems which may arise as the bag is being used, because there is a batch number and expiration date which identifies that particular production run. The canned foods should be covered and stored in the refrigerator for no longer than 3-5 days. I recently purchased a bag of Solid Gold that wasn't vacuum sealed, is it still ok to feed it?Solid Gold dry food bags contain a revolutionary one-way valve system to hermetically seal the bags. Hermetic sealing gives the same effect as vacuum packaging, in that the bag is completely air tight and impervious to external influence. Solid Gold bags are not vacuum packed. Some bags are very rigid, where the air has been completely expelled through the one-way valve. This effect occurs in bags that were stored in the lower part of a pallet or passed through high altitude on their way to their final destination. Other bags, which are not as rigid, still have the airtight seal and protection from the outside environment and are preferred by some customers and stores as they are easier to stack and life. Through extensive shelf life testing, they have found there is absolutely no shelf life difference between the bags that are rock hard and those that are loose. I don't see glucosamine or chondroitin in your large breed or senior formula, why is this?Solid Gold does not have glucosamine and chondroitin added to their products for many reasons. The main one is that there are over and under dosing concerns when added to the food because of the difference in sizes of the dog eating it. It is much more exact to supplement each dog individually, that way small dogs don't get too much and large dogs get enough. Dosing concerns aside, to add the supplement to the food in a large enough quantity to be effective would be cost prohibitive, it is much more economical to supplement after the food is manufactured. The amount that is in the other foods would require between 15 and 20 cups be consumed per day to get the recommended daily amount without additional supplementation. Further, this is currently an unapproved feed additive according to AAFCO. Were they to put it in Solid Gold foods, they would face possible stop sale of their products until it is removed. For these reasons, they have separate joint supplements. Does Solid Gold engage in any animal testing?The only testing Solid Gold conducts on animals is in the form of non-invasive feeding trials. The dogs and cats are fed a variety of food and their preferences are simply monitored and recorded. Feeding trials are the best method of ensure that this food is palatable for dogs and cats and is very necessary to ensure the best product makes it to the market. All dog food companies must assess the nutritional quality and palatability of their food before it can receive approval to be sold. This is currently done with personal pets owned by the employees and associates of Solid Gold. Where are Solid Gold foods made?All Solid Gold products, with the exception of the Blended Tuna canned cat food, are made in the USA. What is the shelf life of Solid Gold treats?Solid Gold's meat based treats are stamped with an expiration date. Their biscuits are stamped with a manufacture date and are good for a year from this date. What is the shelf life of Solid Gold Supplements?Most supplements are stamped with an expiration date. However, there are a few supplements that are stamped with a four-digit manufacture date. The first three numbers are the day of the year and the last number is the year. The powdered supplements with a manufactured date have a shelf life of three years. Do Solid Gold foods need to be supplemented?All Solid Gold foods are complete and balanced according to AAFCO guidelines. Therefore, they do not need to be supplemented with anything. However, Solid Gold does recommend supplementing any commercial pet food with a supplement like Solid Gold Seameal. Seameal contains 60 trace minerals, 12 vitamins, 22 amino acids, digestive enzymes and flaxseed meal. About Solid GoldSolid Gold Health Products For Pets, Inc., has been a pioneer of natural, holistic animal nutrition since 1974. They now have a line of nine dry dog and cat foods, including their new high protein, low carbohydrate dog food, Barking at the Moon. They also have a line of canned dog and cat foods as well as nutritional supplements, treats, and topical products. All Solid Gold dry and canned dog and cat foods are wheat, corn and soy free. They use healthy oils packed with omega fatty acids such as canola oil and salmon oil. Over the years they have updated their formulas as new nutritional research has become available. For instance, a few years ago, they added taurine to all their dry dog foods to help protect against dilated cardiomyopathy. Solid Gold is also an industry leader in the use of revolutionary foil "barrier" packaging for all of their dry food products, which means they don't have to use chemical preservatives or flavor enhancers. Barrier packaging keeps food fresher longer, maintains palatability, and helps to sustain the potency of valuable vitamins and other nutrients, which may deplete over time with conventional paper bags. Solid Gold's PhilosophyThe concept behind holistic health care is that the body should be viewed as a whole structure and not regarded as just a collection of individual parts. All systems within an organism are connected with one another in some way, and any imbalance may disrupt other body systems before physical signs are seen. All aspects of a disorder should be considered in the planning and implementation of a treatment regime, as opposed to treating only the apparent clinical signs themselves. For example, a dog that suffers from chronic skin irritation, ear infections, or chews incessantly at his feet, should not just be treated with steroids, antibiotics or topical applications. The cause should be determined and addressed. Foot-chewing and chronic ear infections are classing signs of food allergies in dogs. Often, a simple changed in diet combined with support for the immune system will rectify the problem within days. Viewing the body as an inseparable structure, and treating the cause of disease (as opposed to "splitting" the body into its individual parts and trying to treat only the visible signs), allows that body which is fundamentally sound, to return itself to normal. Solid Gold selects ingredients from around the world, to produce foods and supplements, which can be used in conjunction with each other. This promotes a healthful whole body, whose systems work in harmony and are enhanced to their maximum potential. Solid Gold's HistoryThe founder and owner of Solid Gold Health Products For Pets is Sissy Harrington-McGill. Sissy went to Germany in 1974 to buy the fawn son of the 1974 world Champion Great Dane and the brindle nephew of the 1973 World Champion Great Dane. She has raised Danes since 1958. While in Germany, she found that German Danes were very healthy and lived to be 11 to 13 years old. The American Danes lived to be only 7 to 9 years old. Sissy believed this difference may have been nutrition related and gathered samples of some German dog foods. Upon returning to the United States, she had the various foods analyzed to determine how they might lengthen the life span of the American Danes. She then developed the Solid Gold Hund-n-Flocken (which means "dog food flakes" in German). This began Solid Gold Health Products For Pets, Inc., The Holistic Animal Nutrition Center. Sissy has a Master's Degree from Columbia University in New York City. She began a doctoral program at the University of California, Berkeley, and complete her coursework at the University of Southern California in Los Angeles. Solid Gold was chosen as the United States Chamber of Commerce Small Business Association, California Exporter of the Year.


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Any way we can ban Gyron?
Jealous of his Belter and Blackjack skills?
If I could find your house, I'd be knocking on your door. But since you hide the location of your webcam so well.....
The little PD icon is back; this time it's the latest logo.
Minor xboxlive feature added. You have to enter your gamertag a second time in another place in your profile (this time it's up with the instant messenger stuff) to make it work, but if you do you'll get what's underneath my avatar and post count.
The above is a minor addition as well. You place text inside the box and you make the "title" of the box whatever you want.
Without the *s do this [*fieldset="title goes here"]IMPORTANT[*/fieldset]
Which would look like this:
New feature: Find user's given location on Google Maps.
Click on the little globe in front of a user's listed location, and it will take you to google maps with that location already entered.
Obviously doesn't work on joke locations.
New minor feature: SendPM button in each post next to Edit and Quote. I've requested LA to make a matching button for it so it doesn't stand out like a sore thumb.
The Google Maps thing is cool. When I clicked on mine it directed me to the Cape Cod Airport and only a few clicks away from my best friend's house.
I got a request, you should install the feature which allows users to change their own username. I want to change my username to Corey Matthews but I dont want to have it for too long.


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Although California American Water has withdrawn from the Regional Desalination Project, the county Water Resources Agency still plans to ask the Board of Supervisors on Tuesday to lift the cap on the company-backed credit line to pay for project expenses already incurred and for unspecified future spending.
However, Cal Am spokeswoman Catherine Bowie said the credit line is not open, and Supervisor Dave Potter said he believes that if the desal project is finished, then the credit line is, too.
Earlier this month, supervisors delayed the agency's bid to lift the cap until more detail was provided on past bills and potential future costs. The board, which capped the agency's access to the Cal Am credit line at $286,000 in March until a project financing plan was complete, did allow access to an additional $62,000 to pay for a low-interest state loan application for the ill-fated desal project at its Jan. 10 meeting.
But that was before Cal Am announced earlier this week that it would no longer support the regional project and its agreements, which were backed by a public-private partnership including the county and the Marina Coast Water District. In backing out, Cal Am cited the failure of months-long mediation and said it would focus on seeking alternative projects.
David Chardavoyne, interim general manager for the Water Resources Agency, said Cal Am and the county had agreed to continue discussions on how to resolve remaining project-related issues and find a solution to the Peninsula's need for a water supply.
Chardavoyne said he couldn't discuss whether the Cal Am credit line is still active or what possible "appropriate future expenditures" the money could be spent on, citing restrictions on discussing the confidential mediation talks among project partners. He said the county is still bound to meet its obligations under the project agreements, even if Cal Am has backed away.
"This was an item the supervisors asked for more information on and for us to return with the request, so that's what we're doing," Chardavoyne said.
Potter said the request is on the board's agenda to underscore the need to address the bills even if there is no identified funding source.
A staff report on the agency's request includes a list of more than $1.43 million in project expenses by "invoice category," identifying specific dollar amounts and the general source of the billing. The list includes nearly $700,000 for project manager RMC Water and Environment and nearly $415,000 in legal costs. The staff report also includes a list of contracts and vendors, the total amount of the contracts, the duties and the percentage of completion.
After the initial $286,000 already approved by the supervisors, the staff report lists $1.15 million needed to cover the rest of the already incurred costs. Most of those costs have been covered by the Water Resources Agency.
Supervisor Jane Parker said a cursory glance at the staff report indicated a lack of enough detail to allow her to approve lifting the cap, and she suggested the report might have been written before Cal Am withdrew from the project.
Critics had earlier blasted the board for considering tapping the credit line when so many questions remained unanswered, including the project's future and the legality of the credit line and the request itself.
Chardavoyne said no progress has been made on the state loan application, nor has he been asked to discontinue that effort.
The county has spent nearly $4 million on the $400 million desal project, which has been beset by delays and controversy, including litigation requiring a new environmental review, alleged conflict of interest involving former county water board member Steve Collins and financing hurdles.
Jim Johnson can be reached at firstname.lastname@example.com or 753-6753.


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So I have been in this forum for a while now I normally post comments and read blogs (must shout out some great bloggers Knox, The Crippler, Rick Starr I know I have forgotten some but will give them a shout out next time). I have decided to write a blog and see if I garner any feedback. It's my first blog and I am going to talk about some of the things that have been going on in the WWE.
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"Is there anything cooler than firefly light reflecting in still-water?" asks Vincent Brady, a photographer who used "every trick" for his first "whole-hog" time-lapse video.
He shot the footage at Lake of the Ozarks, Missouri, where his family gathers, and around Grand Ledge, Mich., his hometown.
"We call them fireflies or lightning bugs, but they aren't a fly or a bug," Brady notes on his website. "They are beetles, and there's over a 1,000 different species of them."
You can visit Brady's Facebook page here.
h/t Smithsonian's SmartNews


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With Jenny Watts
In the winter time when trees are dormant, so are the insects that inhabit them in the summer. Many insects live through the winter cold by crawling into crevices or by laying eggs in the fall which overwinter and come to life when the days begin to warm. This is a good time to stop that cycle.
For well over 100 years, horticultural oil has been sprayed on trees and shrubs in late winter and early spring to kill small, soft-bodied pests such as scale and mites. The oil is mixed with water to make a syrupy solution, that forms a thin film over insects and their eggs and smothers them.?
The old horticultural oil was sold as dormant oil and used only on dormant plants because it could burn leaves. But the more refined oils, now called superior oil sprays, can be safely sprayed on actively growing plants as well as dormant ones.?
Oil sprays have many advantages compared to conventional pesticides. First, the oils are relatively harmless to humans, other mammals and birds. And when they dry, beneficial insects can return. Also, pests are unlikely to develop resistance to the oils, because they kill insects by smothering them, rather than by disrupting their biochemistry, as do conventional pesticides.?
Superior oils control a wide range of pests. They are most effective against small, soft-bodied pests such as aphids, psyllids, mealybugs, scales, whiteflies and mites. They also control, to some degree, immature stages of chewing insects.?
There are a few plants which can be damaged by oil sprays. Blackberries, raspberries, blue spruce and walnut trees should not be sprayed with superior oils. Japanese red maple and dwarf Alberta spruce should only be sprayed at reduced dosages.?
For disease prevention, lime-sulfur was used for years and it is very effective. However, it is no longer available. We have a new product called Serenade?. It is a bacteria (Bacillus subtilis, strain 713) and it is a broad spectrum fungicide/bactericide that controls or suppresses a wide array of fungal and bacterial problems. It should provide excellent control of apple rust and powdery mildew when sprayed on apples every 2 weeks beginning at pink bud stage. It can also be used on pears to suppress fire blight.
Serenade? is also registered for black spot on roses. You can use it now while the plants are dormant, or use Neem oil. Spray ever two or three weeks if the weather is wet, otherwise spray at the first sign of disease problems.
Peach and nectarine trees should be sprayed with copper spray, at least three times during their dormancy, to control peach leaf curl. If you haven't sprayed yet, do that now, before the trees bloom.
Fruit trees, roses and any dormant plants that had insect problems last year should be sprayed now with an oil spray. Deciduous plants are usually sprayed after pruning. This is definitely a case where "an ounce of prevention is worth a pound of cure."
Gardening tips
Roses should be pruned if you haven't done so already.?Remove all old leaves on and around the bushes and spray to prevent early pest and disease problems.
Clean out bird houses.?Remove old nesting material and scrub the inside with a solution of one part bleach to nine parts water.
Flowering dogwoods and tulip magnolias can be planted now during the dormant season from balled & burlapped specimens.
Bare root fruit trees, grape and berry vines, and ornamental trees and shrubs are still available. Bare-root season offers the best selection and the best prices.
Onion plants can be set out now for early summer harvest.?
ABOUT THE AUTHOR: California Certified Nursery Professional Jenny Watts is co-owner of Sanhedrin Nursery in Willits. Visit www.sanhedrinnursery.com.


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CONCORD — The Contra Costa County Sheriff's Office is investigating a homicide in the area of Interstate 680 and Concord Avenue.
Details were not immediately available on the incident, which the sheriff's office reported via Twitter about 9:20 p.m. A phone call seeking additional details was not immeidately returned.
Check back for updates.
Contact Katie Nelson at 925-945-4780 or follow her at Twitter.com/katienelson210.


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Convertible Natural Rocking Horse
|By: Teamson
|For Now and Later!
Our Convertible Natural Rocking Horse is the only horse that can be used from when your Child can sit up on its own. As the child grows older just remove the railing and voila! It transforms into a beautiful wooden rocking horse he can use for many years to come! A special hand crafted and hand painted horse that will be treasured for years.
|Product Rating
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Liquid Force Witness Grind Wakeboard With Domain Bindings
- Additional discounts do not apply.
Exclusive Grind Base
Three stage hybrid rocker
Winged rail shape
Double concave V-tail
Molded-in long-based side fins
The Witness Wakeboard is a fan favorite and people pleaser. This tried and true board has been a staple of the Liquid Force line for years. With an excellent flow and feel, the Witness Grind Wakeboard will help you continue to progress. For a board with unlimited potential, strap into a Witness Grind and let the good times roll. Witness Grind 132: 52"L. For 70-150 lb. riders. Witness Grind 136: 53.5"L. For 100-180 lb. riders. Witness Grind 140: 55.1"L. For 140-225 lb. riders. Witness Grind 144: 56.7"L. For 170-260 lb. riders.
Three Stage Hybrid Rocker
Center curve is designed straighter for consistent edging speed into the wake, corner, or rail. Exaggerated kink out through the tips. Smooth transitions in the tail section for increased ollie power.
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Controlled water flow through the ends creates extra thrust and lift.
Winged Rail Shape
Side slots for extra bite in the flats and quicker release off the wake.
Liquid Force Exclusive Grind Base
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Unbelievable hold with large inside face of the fins while maintaining a low outside profile for no hang-ups.
The lightweight Domain Boot features a baseless design with an integrated heel piece for great heel hold-down, a padded ankle cuff for great ankle support and control, and Velcro closure for easy entry and tightening. Men's sizes: S(5-8), M(8-12), L(12-15).


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From the National Center for Complementary and Integrative Medicine
From PBS - returning the human touch to high-tech care. The traditional doctor-patient relationship is undergoing a shift from paternalism to partnership, as practitioners and consumers alike have begun to promote a more holistic form of healthcare called integrative medicine—seeking to heal the whole person, rather than simply cure a disease.
From The University of Minnesota Center for Spirituality and Healing and The Life Science Foundation. Learn about complementary therapies.
From MEDLINEPlus, a service of the U.S. National Library of Medicine and the National Institutes of Health
From the National Institutes of Health, Office of Dietary Supplements
From the University of Maryland Medical Center
From MEDLINEPlus, a service of the U.S. National Library of Medicine and the National Institutes of Health
PBS FRONTLINE® examines the controversy over complementary and alternative medicine.
This information resource, presented by Memorial Sloan Kettering Cancer Center, provides evidence-based information about herbs, botanicals, supplements, and more.
From the University of Maryland Medical Center. Check for potential interactions between drugs. This tool also contains information on herbs.


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Dec 10, 2013 at 4:40 am
MINNEAPOLIS (AP) — Former University of Minnesota hockey star Lou Nanne, now a prominent Gophers booster, has been picked to lead the school's fundraising campaign for enhanced athletic facilities.
The university announced the news Monday.
With a separate practice building for the men's and women's basketball teams at the top of the list, the Gophers are pursuing $190 million in private money to upgrade their sports programs. Football practice facility renovation is also a high priority.
Nanne will lead a new volunteer leadership council that will assist the athletic department in meeting the needs of the athletes, coaches and programs. Nanne was a star for the Gophers in the 1960s. He went on to major roles with the Minnesota North Stars and Team USA hockey team.
Temp: 63°F (17°C)
Dewpoint: 62
Wind: 12 SE
Weather: mist


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Sunday morning tender plants throughout the Willits area were nipped by frosty conditions as temperatures dropped to 30 degrees in much of Little Lake Valley.
Rainy conditions arrived Sunday night, dropping 1.36 inches of rain as of Tuesday morning.
Snow levels in the coastal ranges dropped down to about 4,000 feet as the first wintry conditions arrived in the area. Thunderstorms with hail were reported throughout the region from Point Arena to Willits to Crescent City.
A new wave of showers is expected arrive Tuesday night, dropping snow at elevations as low as 3,500 feet. This weather band is expected to depart sometime overnight.
Foggy conditions are expected to create driving hazards once the showers depart.
A new band of showers may arrive late Friday afternoon.


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Wine The Spark Of Life Raglan T-Shirt
Product Color:
Product information
The Raglan T-Shirt Wine The Spark Of Life is a sporty version of the popular favorite t-shape. It provides comfort and control over most weathers and can also be worn underneath a t-shirt or a shirt for extra protection. The sporty raglan design gives it a more casual approach.
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Sku: TR1BNBL00002612222220519ORDSWH000


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Biomod/2012/TU Dresden/Nanosaurs/Project/Vesicles
From OpenWetWare
In the very early stages of our project, we decided that our central "tethering species" would be Giant Unilamellar Vesicles (GUVs). We would then attach several DNA origami structures to GUVs via cholesterol modified DNA oligonucleotides. The structure encloses oligonucleotic "catcher strands" and is initially locked by means of an aptamer lock. When a ligand specific to the aptamer is introduced into the system the origami structure would open to reveal these catcher strands. Target species in the solution, which have "receiver strands" complementary to the catcher strands, can then get tethered to the GUVs when the catcher and receiver strands hybridize. We decided that our ideal system would contain Large Unilamellar Vesicles (LUVs) as the "tethered target species".
We decided to start with a simple system consisting of single stranded DNA oligonucleotides on both the "tethering" and "target" species until the DNA origami structures were fabricated .Based on previous research work (Beales P A, Vanderlick T K (2007), Specific Binding of Different Vesicle Populations by the Hybridization of Membrane-Anchored DNA. J Phys Chem A 111, 12372-12380), we assumed that the optimal number of anchored oligonucleotide strands per lipid molecule in the vesicles' membrane was of, 5* 10-3 for GUVs and 4*10-4 for LUVs.
The giant unilamellar vesicles (GUVs) were prepared using electroformation (Hyperlink) and the large unilamellar vesicles (LUVs) were prepared using rehydration and extrusion (Hyperlink). The composition of both of the phospholipid vesicles was the same and consists of 1, 2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC). The charged vesicles had in addition varying volume amounts (0%-10%) of 1, 2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS). For some experiments the lipids were labeled with fluorescent dyes, Fast-DiO with an emission at 488 nm and DiD with an emission at 647 nm. There were two different versions of the SLB buffer (Hyperlink) depending on the experiments. The single stranded oligonucleotides experiments were with SLB; meanwhile for the origami experiments the SLB buffer included magnesium.
Our cholesterol-modified oligonucleotides were three: catcher A (tethering oligonucleotide used only for the experiments with single stranded oligonucleotides (Hyperlink)), anchor-complementary (part of the double-stranded tethering oligonucleotide for the origami structure (Hyperlink)), catcher-complementary (oligonucleotide for the LUVs as target species (Hyperlink)).The only non-cholesterol-modified oligonuclotide used was named as "receiver A" since it consisted in the complementary strand for catcher A. Receiver A was modified depending on the target molecule used for the experiments with single stranded oligonucleotides. The target species were Streptavidin-conjugated Quantum dots 625, Alexa 488, Alexa 488-conjugated Streptavidin and finally LUVs.
The experiments were carried out in multiwell plates, each well having a total volume of 40µl. Before using the imaging wells, we incubated for at least 30 minutes with a solution of bovine serum albumin (BSA) (Hyperlink) which was removed previously to setting the experiments. The imaging was done using Zeiss LSM 780 CC3 (Hyperlink) and the pictures were taken at the equatorial plane of the vesicles.
Experimental procedure
- GUVs electroformation
- Well pasivation (Hyperlink)
- GUVs observation under the light microscope (checking the stability)
- Target species preparation:
- LUVs formation and calibration (Hyperlink).
- Streptavidin-biotin interaction: the biotinylated receiver A oligonuclotide were incubated for 10 min with Quantum dot 625-Streptavidin or Alexa 488-Streptavidin (Hyperlink).
- Anchoring of cholesterol-modified DNA oligonucleotides:
- To GUVs and LUVs: the vesicles were incubated at room temperature for a period of two hours with the corresponding cholesterol oligos. At the end of this process, most strands were anchored to the lipid vesicles NOTE: for the experiments with origami previous to the anchoring, the cholesterol-modified anchor-complementary oligonucleotides were incubated for 30 min to hybridize with the corresponding origami structure.
- Hybridization: the target species were mixed with the GUVs and incubated overnight.
- The well was then imaged using Zeiss LSM 780 CC3 inverse confocal microscope.
Experiments with single stranded oligonucleotides
Our tethering species were always GUVs. Since the previous data on the optimal concentration of the oligos on the vesicles were available only for homogenous systems (consisting either GUVs or LUVs), we started with simple tethered target species (fluorophores) to find the optimal concentration of the components and moved on to our final target (LUVs). The tethering and target systems used in this first stage were the catcher A strands and receiver A strands respectively. The molar ratio between the tethering and target oligos was always kept as 1:1.
Alexa labeled DNA oligonucleoides as target species
In the first set of experiments, receiver A strands labeled with Alexa 488 were used as the target species. The protocol for the labeling procedure can be found here (Hyperlink). In the control experiments, no catcher A strands were used. On imaging along the focal plane, clear distinguishable fluorescent rings were observed around the GUVs. Such rings were not observed in the control wells. This clearly indicated that the receiver A strands were hybridizing with the catcher A strands, resulting in such rings.
Experiment with Alexa 488-receiver A
Control experiment w/o catcher A
Alexa 488 labeled Streptavidin molecules as target species
Subsequently, Streptavidin labeled with Alexa-488 was used as the target species. In the control experiments, no catcher A strands were added. Fluorescent rings were also present around the GUVs.. The control wells didn't present such rings. This confirmed that it was possible to hybridize more than just oligonucleotides.
Experiment with Strept-Alexa 488-receiver A
Control experiment w/o catcher A
Quantum dot 625-Streptavidin as target species
Then we decided to use Quantum dots (QD) since they not only have a high quantum yield but also do not bleach and could provide better quality of images. The QD-625 has an emission maximum at 625nm. It has a size of around 25nm. Biotinylated receiver A was first hybridized with QD-Strep, QD-Strep-receiver A, and then later this complex was added to the GUVs bearing chol-catcher A oligos. The controls did not contain the chol-catcher A oligos on the GUVs. The molar ratio of chol-catcher A : Biotinylated-receiver A : QD-Strep = 1:1:0.5 was used. As opposed to the previous results, a fluoresdent ring around the vesicles was not observed. Even more puzzling was the fact that we could not see the QD in solution.
Gel Analysis
After an unsuccessful approach of visualizing the quantum dots, we decided to check the efficiency of oligo-oligo hybridization and binding to streptavidin coated quantum dots on PAGE. The entire set of the experiments below was performed in 12% PA gel (protocol 1-hyperlink).
Biotinylation and Streptavidin binding
First we checked an efficiency of biotinylation of oligos complementary to cholesterol-coupled oligos. For the gel experiments, oligos without cholesterol were used. There was a shift in the bands between the control oligos and the biotinylated oligo. Also the efficient binding of biotinylated oligo to streptavidin (in lane 4) was observed.
Efficiency of biotinylation reaction. From left: oligo, biotynylated oligo, oligo+streptavidin, biotynylated-oligo+streptavidin
Optimal QD-Oligo ratio
In order to optimize the ratio of quantum dots to the oligonucleotides, different ratios of quantum dots were applied to constant amount of oligonucleotides (70ng). The optimal molar ratio of oligonucleotides to quantum dots was found to be 2:1 since the amount of oligonucleotides not bound to quantum dots was less and also to have a high probability that a single quantum dot is bound by just two oligonucleotides. The other lanes have more free oligonucleotides and therefore would lead to more unspecific binding in solution.
From left: oligonucleotide w/o biotin+QD; Ratio biotinylated-oligonucleotides:QDs 1:1,2:1, 3:1, 5:1,7:1, 10:1.
Oligo and Quantum dot hybridization
Finally, the complete system used for the experiments (in 3.1.) (hyperlink) was checked on the gel. The results show that catcher A hybridizes with receiver A with high efficiency. However when QD was added, efficiency drops down significantly.
From left: catcher A, biotinylated catcher A-complementary and catcher A + Qds added 30 min later, biotinylated catcher A-complementary and Qds incubated separately + catcher A added 30 min later, biotinylated catcher A-complementary + catcher A
Spectral analysis of Quantum dots
We were facing some difficulties in observing the quantum dots both in solution and on the lipid membranes. A poor signal was observed even at high laser powers in confocal microscopy. The PA gels proved that there was no problem with the hybridization of QDs to biotinylated-oligos. Therefore, pure QDt samples of different concentrations were prepared and directly observed on cover slips and bright QDs at relatively low laser power could be observed. Then, we obtained the spectra of these QDs by doing a fluorescence emission scan (excited at 458nm). A peak signal was observed at 615-625nm which is consistent to the QD manufacturer specifications used. When the same analysis was done with our vesicles samples mentioned before, we found that the spectra was not the same as of the QDs due to the background fluorescence of the contaminated lipids samples at high laser powers. This prompted us to increase the concentration of the quantum dots from 0.1 nM to 10 nM. Subsequently, the concentration of the cholesterol-modified oligonucleotides was increased 50-fold.
Fluorescent emission scan
Vesicles sample
Quantum dot 625-Streptavidin as target species (Higher concentration)
With the concentration mentioned before, bright fluorescent rings were observed around the GUVs and none in the controls. Thus, we were able to target a large species like quantum dots on the vesicles.
Experiments with DNA Origami
We then proceeded with the experiments using our DNA origami structure. To prevent unspecific binding, we used GUVs with 10 mol% negative lipid species of DOPS for all the experiments. The anchor-complementary and catcher-complementary oligonucleotides were used for these experiments.
Vesicles with different amounts of origami
Various amounts of origami were used to find the optimum concentration required to visualize them on vesicles. We observed fluorescent rings around the GUVs with 4µl and 8µl of the assembled origami. It was decided to use 8µl (2.5 nM) of origami for further experiments since it gave a bright ring and also since we wanted to minimize our origami consumption. The controls did not have any origami.
Experiment with 4µl of DNA origami structure
Experiment with 8µl of DNA origami structure
Experiment with 16µl of DNA origami structure
Control experiment w/o anchor-complementary oligos for 8µl
Alexa 647 labeled catcher complementary DNA oligo strands as target species for the DNA origami structure
After obtaining very promising results with the origami anchorage into the GUVs, we wanted to find out whether the catcher strands on the origami are able to hybridize with the catcher-complementary strands properly. We used Alexa 647-labeled (emission) catcher-complementary strands to hybridize with the origami catcher strands and the GUVs were labeled green (emission) with DiO. The control had the closed origami. We observed a strong ring around the GUVs with the open origami. In the control we observed no ring around the GUVs. With this positive result for the origami, the following step was to repeat the experiment using the LUVs targeting system.
Experiment with open DNA origami structure
Experiment with closed DNA origami structure
LUVs with catcher complementary strands as target species
After the positive results of the origami anchorage into the GUVs we proceeded to prove the correct hybridization of Fast-DiO fluorescent (Green) LUVs. The catcher-complementary strands anchored on the LUV surface were hybridized with the catcher strands on the Alexa 647-labeled origami structure in the open configuration. We included two controls, one with a closed origami and one without origami. We observed LUVs on the GUVs surface in both configurations of DNA origami and also in the control without the origami. The uncharged (without DOPS) LUVs tended to unspecifically bind with the GUVs.
Experiment with open DNA origami structure
Experiment with closed DNA origami structure
Experiment w/o DNA origami structure
LUVs with 10 mol% negative charge (DOPS) with catcher complementary strands as target species
When unspecific binding of uncharged LUVs was observed, we decided to use LUVs with 10 mol% negatively charged lipids (DOPS). In this case we did not observe unspecific binding neither in the samples with origami nor the control without origami.
Experiment with open DNA origami structure
Experiment with closed DNA origami structure
Experiment w/o DNA origami structure
GUVs with 10 mol% negative charge (DOPS) with catcher-complement strands as target species
In parallel, we were trying to tether two classes of GUV. The LUVs in the previous experiment was replaced by GUVs. In the beginning GUVs only labeled in the same way with one dye were used. The control did not have the catcher-complement strands. The experiment brought surprising results. The vesicles seemed to be attracted to each other when the open origami structure was used. They seemed to change their shape in order to increase the contact area between them. We also noticed that the fluorescence in the interface between the tethered vesicles was much more intense than in the control hence suggesting that the interaction was mediated by the origami structure.
Experiment with open DNA origami structure
Control, w/o catcher-complementary oligos
Encouraged by the results with uniformly labeled vesicles we had prepared two classes of vesicles stained either with red fluorescent dye (DID) or with green (DIO). In the controls without the catcher-complementary strands, the GUVs do not cluster and do not seem to attract each other.
But, we could also notice vesicles being attracted to each other with the closed origami structure. This led us to conclude that the structures are not totally closed.
LUVs with variable (3-7 mol%) negative charge (DOPS) with catcher complementary strands as target species
We needed to optimize the amount of negative charge such that Fast-DiO labeled (Green) LUVs could interact with DiD labeled (Red) GUVs in the presence of origami, but not cluster in its absence. We started by preparing LUVs with 3 mol% DOPS. There were controls with the closed origami, without any origami and one more without origami but with the catcher-complementary. Bright rings were present in all the samples including the controls.
Open origami 3%PS
Control with closed DNA origami structure
Control with no DNA origami structure
Hence, we needed to use a medial value between 3 and 10 mol% and therefore LUVs with 7 mol% DOPS were prepared and targeted by the Cy3-labeled origami on the GUV surface. The previous controls were repeated for this experiment also. Bright fluorescent rings were present in both the samples with open and closed origami structures, but it was not present in the control with catcher-complementary strands. Thus, we decided that the optimal negative charge of 7 mol% was required on the LUVs to screen the unspecific binding. Also, the reason for a fluorescent ring with the closed structure might be due to the fact that the origami is open and further corroborates the findings from the experiments with GUVs.


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Amazing Street Drummer
Direct link to this video:
Show it on your blog, online profile or website:
Great Big Story visits the studio of Denver-based sculptor Landon Meier to check out his incredibly lifelike hand-made "Hyperflesh" masks of polititions, celebrities, and nightmare-inducing children
'You've got to be sh*tting me!' A Colorado Springs family has spent weeks trying to find and stop a mystery woman they've called 'The Mad Pooper' to stop defecating in their neighborhood, right outside their house.
Do you have trouble decoding the often mysterious and often confusing hints and ways of women? Like the way 'It's fine' means that it definitely is not fine? This hilarious video should help as it reveals what women really mean.
Once upon a time, there was a 1,100-page book called IT. Then there was a TV miniseries based on the book. (And now there's a feature-length film). CineFix breaks down the changes you can expect to see between the book and miniseries.
Adam Schleichkorn celebrates the upcoming season 9 premiere of Larry David's HBO comedy series, Curb Your Enthusiasm, with this funny mashup of SpongeBob and Squidward as they reeneact the 'empty gesture' scene from the seventh season of the show.
News Be Funny have put together this entertaining and amusing clip compilation of the best and funniest bloopers that happened during live news coverage of Hurricane Irma.
Shot with a GoPro, this guy went skiiing and then, because the world didn't know it needed it but it so did, he then stabilized the video on his nipple. Back in the past people thought the 21st would bring flying cars, but no instead it's brought us this.
Russian YouTube user Dexturt provides a thorough, thoughtprovoking, and heartwarming analysis of a viral photo of a cat sitting next to a big plate of pancakes (aka blin in Russian).
Holy crap this is fast. 15-year-old teen Patrick Ponce just set crazy new world record for solving a Rubik's cube, in an insane 4.69 seconds—but it's not something that can be done with a regular Rubik's, Ponce uses a Boron Valk M which has 48 neodymium magnets.
Over in England recently, due to parliamentry clock Big Ben closing down for repair work, and ceasing to go 'bong', an 8yo girl went on British television stating she wanted the job of imitating Big Ben's bongs. And, of course, someone on the internet turned it into a remix.
In all that dust, there's a car in there somewhere. Ken Block took a break for tearing up urban areas and got back to nature in Swing Arm City, Utah. Using the terrain as a natural stunt course, Ken sent his Ford Fiesta ST RX43 rally car flying through some of the best trails in the US.
How funny are bulldogs? Well as this video shows they can be very funny and very daft too. Sure you're spending your time watching a video compilation of dogs being silly, but what else have you got to do?
Andy Schneider and Jonathan Britnell of Burger Fiction use Marvel's 2017 superhero film, Guardians Of The Galaxy Vol. 2, as an example of what it takes to make a movie sequel worth watching in this interesting video essay.
Song lyrics site MetroLyrics put together this entertaining music mashup of smash hit summer songs, in reverse chronological order, from 2017's 'Despacito' by Luis Fonsi and Daddy Yankee to 1958's 'Nel blu dipinto di blu' by Domenico Modugno.
Grow Cable is an umbilical cord smartphone cable that pulsates as it charges. The creator says it was designed as social commentary on the growing dependence over smart phones. The cable currently sells for crazy $5,693.95 on Etsy.


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"Nobody wants to play against Tyler Hansbrough NO BODY!" ~ Frank Vogel
"And David put his hand in the bag and took out a stone and slung it. And it struck the Philistine on the head and he fell to the ground. Amen. "
Indiana is not running a "not enough basketballs to go around offense" right now, lol so his role will be what it always has been......score points. I am really excited about possibly getting him back. I think for the people that are worried about it potentially hindering PGs continued growth that you need not be. Danny's presence will put a dilemma on a lot of teams for example the Bulls.....with our current line up they would obviously have Deng on PG, Hamilton (if he's healthy) on Lance....but with a Granger line up Deng would most likely be forced to defend Danny and it'd leave PG matched up with Hamilton. Teams will run into situations like this a lot and it will only help create better scoring opportunities for PG. This will also give us more of an opportunity to see how PG has grown as a player in using his length to his advantage on the court, teams will be forced to defend him with smaller 2 guards on a much more regular basis and hopefully PG can continue to use his size to his advantage. He may not necessarily get the volume of scoring opportunities he is getting now, but the scoring opportunities he does get should be better ones. The main thing that Granger brings is free throw attempts, something hopefully PG continues to improve on. The Pacers were a poor FG% team last season as well but they scored a solid amount of points per game because they shot a lot more free throws than our opponents and we offensive rebounded well. So if Danny is still able to attack the basket like he was his added free throw attempts will be huge for our offense.
everything typed here I agree with
"How has it changed you?
Granger: My life is now devoted to my children. It has made me more responsible.
What music are you listening to these days?
2 Chains."
That cracked me up.


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THE man who is now in charge of policing across Worcestershire officially took office today.
Bill Longmore was elected as the first Police and Crime Commissioner for West Mercia earlier this month.
His appointment signals a new era in local policing governance and he will now be responsible for controlling the budget and setting police priorities.
He will also have the power to hire and fire chief constables, but will not be involved in the operational side of the force.
Mr Longmore said: "I am really excited about my new role and I am particularly looking forward to making a real difference to local policing."
He took the Police and Crime Commissioner oath of office with Robin Durham JP, vice chair of the West Mercia Police Authority, after the election on Friday, November 16.
For further information about the PCC visit westmercia-pcc.gov.uk


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Best SellersBest Selling Photos Best Selling Wall Art
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Thanks for your interest in this special offer.
Unfortunately the special has expired, but please visit the Clemson Photo Store
now to find your favorite sports and campus pictures.
You may use the discount code RP2L4dL1 at checkout to get 10% off your order.
Click here to begin shopping.


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Lakeside High School's 2014 graduation ceremony was held on Saturday, May 24th, at the James Brown Arena in downtown Augusta.
Once again, WJBF News Channel 6 and River City Video Productions partnered to have cameras there to record the entire ceremony.
We now have this video archived online. Click on the appropriate video in the playlist above to view the ceremony.
If you would like to purchase a DVD copy from a recorded graduation ceremony from River City Video Productions, please click here. (Note: ordered DVD's will be mailed once editing is completed. Also, the quality of the finished DVD is much, much higher than the video produced for the website, due to online bandwidth constraints.)


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Is cognition, mind contact or consciousness restricted to internal contacts? Why?
Is eye consciousness limited to internal relationships such as the eye perceptions of the bodily eye or can cognition make more direct contacts beyond internal mind qualities and the body's sense perceptions? Is external contact limited to and always meditated by the body senses?
The perception of external objects is often said to be limited to mediation via the body senses but is this so? Can consciousness operate externally beyond the body and the senses? Cannot consciousness also arise through contact with what is external to the body and it's senses as contact causing mind consciousness, etc., etc., eye consciousness apart from the body and the senses of the body?
I don't understand the doctrinal basis for the commonly expressed thinking that cognitive contact is restricted to mediated sensory contact with what is external via the senses of the individuated body. I don't see why eye consciousness, ear consciousness, etc. should be considered restricted to a relationship with the body senses.
I would like to see a presentation of clear supporting statements in the Tipitaka, etc. for the thinking that mind is restricted in it's contacts to only a single continuum of dependently interrelated bodily forms, sense consciousness meditated via the body senses and directly related ongoing proximate mental qualities. In my understanding this is quite distinct thinking from that describing consciousness as restricted to contact with conditions both internally and externally which are anicca, dhukkha and anatta.
It is my perception that a mind may demonstrate the faculty to contact the external apart from meditation by the five senses of the body. How else but by such contact could mind have direct knowledge of another mind, etc., as variously depicted in the suttas, etc.. I do think that, for the duration of life, mind in a human being persists in dependence upon the bodily form but I do not perceive that consciousness is bound by that form. Much like the relationship between an occupant and a house, conscious contact or clinging may abide internally or it may wander externally. There is an intimate conditional interdependence of mind and body for the maintenance of human life but it is not an absolute imprisonment of the consciousness within it's own mental qualities, bodily forms and senses.
Feel free to disagree or to correct any misapprehension with sound doctrine to the contrary.


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Growing up for me was different than for most people I would have to say. I had an older brother who was kind of a douchebag and he was always taking drugs so it would really piss me off sometimes. We started a business together when we both got older and he would always try to act like the boss of me. He was still doing drugs so I would have to work twice as hard just so the business could stay afloat. We also both liked the same girl and he was always trying to get me to help him hook up with her, which really bothered me. I helped him anyway since she was out of both our leagues so it didn't really matter anyway.
One day I come into work and he's already high as f*ck, talking about how bad he wants to get with this girl, calling her his little princess and telling me the things that he would do to her. I can't control myself, I snap and tell him to respect her and that he needs to start working more and stay off the drugs. Well, he flips the f*ck out, telling me to get out of his sight before something bad happens. Then about 30 minutes later he comes stumbling into my office and has a big handful of mushrooms which he tells me to eat or he's going to f*ck me up. He says he needs someone else to be on his "same level". I don't have any other options than to take the drugs, which I've never done before.
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The Icon. The Enigma. The man called Sting. What a career this legend has had. Clash of Champions going 45 minutes with Ric Flair for the NWA World Heavyweight title. Finally beating Flair at Starrcade for that same title. The bull-rope matches with Vader. His epic feuds with the Four Horsemen. I can go on and on. He spent over a decade as the Franchise of WCW before its demise. Vanished into
The Attitude Era. Often defined as the introduction of sex, violence and unexpected plot twists in the world of professional wrestling. It is in the Attitude Era that one of the most influential figures in professional wrestling history had his greatest success as a performer and laid the groundwork for what would become today's WWE. We are talking about none other than The Game; HHH.
Updated 10-19-2013 at 08:47 AM by Chris1978
© 2011 eWrestlingNews, All Rights Reserved.


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Posted 6 years ago
(6 items)
I found this blond haired porcelain bisque doll over Christmas in a rural thrift store, and she was in immaculate condition and had this really sweet almost kewpie doll 1940s face. I was guessing 1970's because of the "little house on the prairie" brown calico dress, but a friend emailed and said she had one she inherited from her mother awhile back, and so thought the doll was at least 60 years old. There are no marks to indicate who made the doll. She also mentioned she had seen the doll on an episode of Dr. Quinn Medicine Woman, so maybe the doll was a museum replica doll, or museum edition doll. We'd both like to know what to call our dolls, who made them and how old they are, and any story on them. Thanks!


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Tribe not expected to make major additions
CLEVELAND -- Despite entering Tuesday four games back in a tight American League Wild Card race, the Indians have not been expected to be heavy buyers ahead of the non-waiver Trade Deadline on Thursday largely due to their financial limitations.
But for Terry Francona, those conditions were a big reason why he chose to bring his managerial talents to the city where his father, Tito, once played.
"You're working under different parameters, but when the game starts you're not hamstrung," Francona said. "If we have to play better or develop younger players, I made that decision because I wanted to be here. I would rather embrace that than worry about what we don't have."
The Cleveland skipper noted that the front office plans to carry the mantra of player development into Thursday's Deadline, as well.
"That's one of the things that's maybe a misperception in our game, is you have to get a veteran guy," Francona said. "One of the things when I came here that was very appealing was the idea of helping younger players get better and compete. That's something we don't want to run away from."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. Alec Shirkey is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Yeah, yeah, you've heard it all before: "the new year is the perfect time to get organized." Enough of the talk—let's do the walk! There's a lot we pack into each and every year, and one way to take charge of our busy lives is by starting the year off right. Whether you're looking for a quick fix to tackling your tasks, or need to do a complete organization overhaul, here are some tips to help you achieve a more organized year.
2. Keep key info handy for referencing.
All information is not created equal; some are just more important than others. Whether you're planning the household budget for the new year, building a binder for your tax paperwork, or even putting together a health record for your family and/or pets, keep all your key information together. One solution is the Avery Heavy-Duty Binder—it's portable and easy to access, designed for frequent and long-lasting use, and built to resist wear and tear.
3. Move paperwork off your desk.


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Concert pianist John Briggs filmed a naked 14-year-old Sea Cadet and then fondled him, a court heard.
The incident was alleged to have taken place at the musician's house in East Morton, near Keighley, in the early 1990s, Bradford Crown Court was told. Briggs, 65, of Little Lane, East Morton, has pleaded not guilty to nine charges of indecently assaulting a male person and one of indecency with a child. The allegations involve two former piano students and three former members of Keighley Sea Cadets, covering a 25-year period beginning in the late 1960s.
The jury yesterday heard the evidence of the fourth complainant. In a video recorded interview with the police, the man said he was a Sea Cadet aged about 14 at the time of the alleged incident. Briggs was president of the Cadets.
He said: "Everybody looked up to John Briggs. I suppose he was a father figure."
He said he went with a friend to Briggs' house to do gardening. He said Briggs told them he had been paid £500 to do glove modelling and asked if they would be interested.
The man said they were taken separately to a downstairs living room where Briggs was sat on a sofa and holding a camcorder. He said he stood on a plinth and was told to strip off, rotate and shout out his height, weight, age and eye colour, while the defendant filmed him.
He claimed Briggs then told him to stand in front of him and the musician indecently assaulted him with one hand while filming with the other. He said he was shocked and froze, and now felt disgusted. He said it had affected him as an adult and he had trouble standing naked in front of his wife.
Questioned by Briggs's barrister, Nick Askins, he said he did what he was asked because Briggs "was the boss and was a big bloke." He had not gone to police because "nobody's going to believe a kid."
The trial continues.


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Norwegian Getaway
4 out of 5 stars
Download the FREE app and meet your ship mates!
Read the best port reviews and tips for this cruise itinerary.
|Day 1
|Miami, Florida
|Day 2
|At Sea
|Day 3
|Coxen Hole, Roatan, Bay Islands, Honduras
|Day 4
|Harvest Caye, Belize
|Day 5
|Costa Maya (Mahahual), Mexico
|Day 6
|Cozumel, Mexico
|Day 7
|At Sea
|Day 8
|Miami, Florida
A roll call is a space for members who are signed up for the same cruise (same ship & departure date) to connect.
Make friends BEFORE you sail, exchange tips on what to do onboard and in the ports and maybe even organize a shore excursion with your ship mates.


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Lenalidomide, Dexamethasone and Cyclophosphamide in Amyloidosis (AL)
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2014 by Meletios A. Dimopoulos, University of Athens.
Recruitment status was: Active, not recruiting
Recruitment status was: Active, not recruiting
University of Athens
Hellenic Cooperative Oncology Group
Information provided by (Responsible Party):
Meletios A. Dimopoulos, University of Athens
ClinicalTrials.gov Identifier:
First received: September 19, 2009
Last updated: January 30, 2014
Last verified: January 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to determine the safety and activity of the combination of lenalidomide with intermediate dose dexamethasone and cyclophosphamide in patients with primary systemic (AL ) amyloidosis.
|Drug: Lenalidomide, Dexamethasone and Cyclophosphamide
|Phase 1 Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase I/II Trial of Lenalidomide Combined With Cyclophosphamide and Intermediate Dose Dexamethasone in Patients With Primary (AL) Systemic Amyloidosis
Resource links provided by NLM:
MedlinePlus related topics: Amyloidosis
Drug Information available for: Dexamethasone Cyclophosphamide Dexamethasone sodium phosphate Dexamethasone acetate LenalidomideU.S. FDA Resources
Further study details as provided by Meletios A. Dimopoulos, University of Athens:
Primary Outcome Measures:
- To assess the maximum tolerated dose of lenalidomide and cyclophosphamide and assess the hematologic response rate of the combination of Cyclophosphamide/Dexamethasone plus lenalidomide in patients with AL amyloidosis. [ Time Frame: At month 2 for assesment of maximum tolerated dose and monthly for hematologic response ]
Secondary Outcome Measures:
- To assess the toxicity of Cyclophosphamide/Dexamethasone plus lenalidomide combination in patients with AL amyloidosis and organ response rate [ Time Frame: Monthly for toxicity and every 3-6 months for organ response ]
|Study Start Date:
|February 2008
|Estimated Study Completion Date:
|February 2015
|Primary Completion Date:
|December 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment
Lenalidomide, Dexamethasone and cyclophosphamide
Drug: Lenalidomide, Dexamethasone and Cyclophosphamide
Lenalidomide capsules on days 1 to 21. the dose starts at 5 mg/day up to 25 mg/day.
Dexamethasone tablets on days 1 to 4. Dose 20 mg per day.
Cyclophosphamide tablets on days 1 to 10. The dose starts at 50 mg per day up to 100 mg per day.
The cycle is to be repeated every 28 days (4 weeks)
Other Names:
Detailed Description:
Primary systemic amyloidosis (AL) is a plasma cell dyscrasia where amyloid fibrils are formed by monoclonal immunoglobulin light chains and deposit in various organs causing tissue damage and dysfunction. It is a rare disease with an incidence of 8 patients per million per year. Virtually all patients die of this disease with a median survival of 12-18 months and less than approximately 5% surviving 10 years. The current therapeutic approach to systemic amyloidosis is based on the observation that amyloid deposits can be reabsorbed and organ function can be restored if the concentration of the amyloidogenic precursor is reduced. The recognized standard treatment for patients with amyloidosis is alkylating agent-based chemotherapy - some selected patients can be treated with high dose melphalan with autologous stem cell transplantation. Recent studies have led to an improved understanding of the biology of plasma cells. Interactions between the bone marrow microenvironment and plasma cells have a critical growth regulating influence on myeloma cells. Thalidomide has shown significant activity in multiple myeloma patients with relapsing or refractory disease and even more in newly diagnosed patients. However, thalidomide causes somnolence, fatigue, constipation, and peripheral neuropathy and is not well tolerated in patients with AL amyloidosis. Lenalidomide is a small molecule structurally related to thalidomide with potent immunomodulatory effects. Lenalidomide has been found to be significantly active in relapsed multiple myeloma both in vitro and in Phase I, II and III clinical trials, including patients who had previously failed thalidomide. Unlike thalidomide, lenalidomide causes no significant sedation, constipation, neuropathy, or rash. Deep vein thrombosis ,especially in combination with dexamethasone, has been reported . Combination of thalidomide with with alkylating agents (such as melphalan or cyclophosphamide) have been very active in patients with myeloma and have superior activity than combinations of alkylating agents with steroids alone. However, the toxicity profile of thalidomide is problematic for this combination in patients with AL. combinations of lenalidomide with alkylating agents (Melphalan + prednisone +Lenalidomide)are feasible and very active in patients with multiple myeloma. Cyclophosphamide has a more favorable toxicity profile than melphalan when used in oral combinations with dexamethasone and thalidomide. However, given the remarkable antimyeloma activity of lenalidomide, overall improved toxicity profile of lenalidomide compared with thalidomide and a need for improved treatments for this incurable malignancy, the combinations of lenalidomide are worthy of study. Preliminary data from Mayo clinic using CC-5013 and dexamethasone demonstrates that lenalidomide is tolerable and has activity in patients with AL amyloidosis and may be useful in patients with AL amyloidosis who either are not candidates for high dose chemotherapy and peripheral blood stem cell transplantation or who have failed prior therapies. Efficacy and tolerability of oral cyclophosphamide , combined with dexamethasone and thalidomide, is well documented in patients with refractory or relapsed multiple myeloma while this combination has been used in patients with AL amyloidosis . Intermediate dose dexamethasone is tolerable and without significant toxicity in patients with AL amyloidosis . The combination of alkylating agents with thalidomide and dexamethasone has been effective in patients with AL amyloidosis . The combination of an alkylating agent with Lenalidomide and intermediate dose dexamethasone may lead to more rapid hematologic responses than either agent alone , and subsequently may lead to increased organ response rates . Therefore, in this phase I/II trial we explore the safety and efficacy of the combination of the alkylating agent cyclophosphamide to lenalidomide and intermediate dose dexamethasone in patients who are no candidates for high dose melphalan chemotherapy with autologous stem cell transplantation.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Understand and voluntarily sign an informed consent form.
- Age >=18 years at the time of signing the informed consent form.
- Able to adhere to the study visit schedule and other protocol requirements.
- Confirmed diagnosis of AL amyloidosis (see appendix 3)
- Need for treatment in the judgment of their treating physician
Evaluable or measurable disease defined by any of the following:
- Measurable serum free light chains >= 10 mg/dL, kappa or lambda, provided kappa/lambda ratio is abnormal (measurable disease)
- Monoclonal protein in the serum >= 1 g/dL
- ECOG Performance Status (PS) 0, 1, 2 or 3
Laboratory test results within these ranges:
- Absolute neutrophil count >= 1.5 x 109/L
- Platelet count >= 100 x 109/L
- Serum creatinine >= 2.5 mg/dL
- Total bilirubin >= 1.5 mg/dL
- AST (SGOT) and ALT (SGPT) > 2 x ULN or > 5 x ULN if hepatic metastases are present.
- Women of childbearing potential (WCBP)† must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL 10 - 14 days prior to therapy and repeated within 24 hours of starting study drug and must begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 4 weeks before she starts taking lenalidomide. Women must also agree to ongoing pregnancy testing. Men must agree not to father a child and agree to use a condom if his partner is of child bearing potential. (See Appendix 1 Pregnancy Testing Guidelines and Acceptable Birth Control Methods.)
- Disease free of prior malignancies for >= 5 years with exception of currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma "in situ" of the cervix or breast
- Able to take aspirin (81 or 325 mg) daily as prophylactic anticoagulation. (patients intolerant to ASA may use low molecular weight heparin).
Exclusion Criteria:
- Patients with symptomatic multiple myeloma with asymptomatic biopsy confirmed AL amyloidosis (Appendix 3)
- Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form.
- Pregnant or breast feeding females. (Lactating females must agree not to breast feed while taking lenalidomide).
- Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study.
- Use of any other experimental drug or therapy within 28 days of baseline.
- Known hypersensitivity to thalidomide.
- The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs.
- Any prior use of lenalidomide.
- Concurrent use of other anti-cancer agents or treatments.
- Known positive for HIV or infectious hepatitis, type A, B or C.
- > grade 2 peripheral neuropathy
- Life expectancy < 3 months
- Concurrent use of steroids (Patients may receive prednisone up to 20 mg/d, or equivalent corticosteroids for concurrent illness or adrenal replacement therapy
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00981708
Please refer to this study by its ClinicalTrials.gov identifier: NCT00981708
|Alexandra Hospital , Department of Clinical Therapeutics
|Athens, Attica, Greece, 115 28
Sponsors and Collaborators
University of Athens
Hellenic Cooperative Oncology Group
|Principal Investigator:
|Meletios A Dimopoulos, MD
|University of Athens, School of Medicine
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Meletios A. Dimopoulos, University of Athens:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Gavriatopoulou M, García-Sanz R, Kastritis E, Morel P, Kyrtsonis MC, Michalis E, Kartasis Z, Leleu X, Palladini G, Tedeschi A, Gika D, Merlini G, Sonneveld P, Dimopoulos MA. BDR in newly diagnosed patients with WM: final analysis of a phase 2 study after a minimum follow-up of 6 years. Blood. 2017 Jan 26;129(4):456-459. doi: 10.1182/blood-2016-09-742411. Epub 2016 Nov 21.
Dimopoulos MA, García-Sanz R, Gavriatopoulou M, Morel P, Kyrtsonis MC, Michalis E, Kartasis Z, Leleu X, Palladini G, Tedeschi A, Gika D, Merlini G, Kastritis E, Sonneveld P. Primary therapy of Waldenstrom macroglobulinemia (WM) with weekly bortezomib, low-dose dexamethasone, and rituximab (BDR): long-term results of a phase 2 study of the European Myeloma Network (EMN). Blood. 2013 Nov 7;122(19):3276-82. doi: 10.1182/blood-2013-05-503862. Epub 2013 Sep 4.
Kastritis E, Terpos E, Roussou M, Gavriatopoulou M, Pamboukas C, Boletis I, Marinaki S, Apostolou T, Nikitas N, Gkortzolidis G, Michalis E, Delimpasi S, Dimopoulos MA. A phase 1/2 study of lenalidomide with low-dose oral cyclophosphamide and low-dose dexamethasone (RdC) in AL amyloidosis. Blood. 2012 Jun 7;119(23):5384-90. doi: 10.1182/blood-2011-12-396903. Epub 2012 Apr 18.
|Responsible Party:
|Meletios A. Dimopoulos, Professor of Medicine, University of Athens
|ClinicalTrials.gov Identifier:
|NCT00981708 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 19, 2009
|Last Updated:
|January 30, 2014
Keywords provided by Meletios A. Dimopoulos, University of Athens:
newly diagnosed
primary systemic AL amyloidosis
Additional relevant MeSH terms:
Proteostasis Deficiencies
Metabolic Diseases
Dexamethasone acetate
Anti-Inflammatory Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Immunosuppressive Agents
Immunologic Factors
Antirheumatic Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Myeloablative Agonists
Angiogenesis Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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I discovered I could incorporate several activities I enjoy within a single hobby. I like spending time with my family and friends, solving puzzles, seeking out new adventures, exercising and being environmentally "green." Geocaching is treasure hunting with a GPS receiver. You can search for geocaches online by zip code and download the coordinates into [...]