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Popping wheelies in the sky at Bridge Day (with video)
a larger version of the video here. FAYETTEVILLE, W.Va. -- With a parachute on his back, Lonnie Bissonnette rolled his wheelchair off the 876-foot New River Gorge Bridge and floated in the air for a few seconds until he landed safely on the ground below.A half hour before his leap, Erika and Patrick Steiner -- surrounded by supportive strangers -- said their "I dos" and then made their second big leap of the day.And although he was scared to jump a second year in a row, Donald Cripps, 83, of Florida, was the oldest BASE jumper at West Virginia's 33rd annual Bridge Day celebration. It's the only day of the year that people are allowed to legally jump from the world's second-longest single-arch bridge.About 450 people took part in 1,036 jumps during the largest extreme sports event in the world in Saturday's chilly, cloudy weather.Many jumpers wore kneepads, hiking shoes and helmets with video cameras. People wore bright, colorful outfits and a couple of people jumped in their American-flag shorts.BASE jumping -- an acronym for the four categories of fixed objects for jumpers: building, antenna, span and earth -- during Bridge Day is exciting because it brings people together who have the same interests, Bissonnette said."I love Bridge Day because we get to see jumpers from all over the world. It's a family reunion here, and I enjoy catching up with everyone," Bissonnette, 47, said.Bissonnette was the only person to fall through the sky in a wheelchair Saturday. The Canadian -- who has been to 16 Bridge Days -- also made the jump in his wheelchair in 2010, he said. Bissonnette was injured in July 2004 while attempting a quadruple gainer (an outward facing, inward rotating flip) on his 1100th BASE jump off a 486-foot-tall bridge. The lines of his parachute tangled around his foot, not allowing his parachute to fully open during the fall.That hasn't stopped the extreme athlete, who most recently jumped off the world's highest tunnel-to-tunnel suspension bridge, in China."It's very fulfilling to be able to continue to come back here to jump," Bissonnette said before he jumped. "I know I'm tense and nervous, but the tension from [spectators] is unbelievable."More than 100,000 people crowded the New River Gorge Bridge and surrounding area. The West Virginia State Police closed the bridge to regular traffic and rerouted it onto U.S. 19.Some people leaned over the side of the bridge to get a better look at the colorful parachutes as they got smaller and smaller the closer they reached the ground. Others snacked on homemade pies, large turkey legs and aromatic kettle popcorn as they walked by around 100 vendors of all sorts.Daredevils did back flips and handstands off the platform in the middle of the bridge. To the right of that stand, a few jumpers lunged from a bouncy diving board into the sky.For the first time ever, to the left of the platform, others were tossed from a pneumatically operated steel catapult as the crowd cheered in awe. The catapult flung BASE jumpers 50 feet laterally and 20 feet vertically off the deck of the bridge. Jason Bell, who heads Vertical Visions, a Bridgeport-based firm that coordinates Bridge Day jumping activities, designed the catapult.A father and son jumped after first-timers and frightened thrill-seekers. By 11:15 a.m., every jumper had taken a fly in the sky at least once, and adventurers went back for more.Once was enough for Erika Steiner, who not only got married on top the bridge Saturday but also won the Bridge Day 2012 Tandem BASE Jump Contest. Steiner, 27, from Lockport, N.Y., got to jump for free and had $1,000 donated to Mental Health America, the charity of her choice.Although it Steiner's idea to have a Bridge Day wedding, her 24-year-old groom, Patrick, said he was on board from the beginning. The two wore matching bride and groom hoodies for their wedding jump."Originally, we played with the idea of having a sky-diving wedding," Patrick Steiner said, "but ... we moved it up to have it as soon as we could, so Bridge Day was be the next best idea."Subaru, one of the event's sponsors, bought the Steiners a cake with mini parachutes on it and provided a banner for all the jumpers to sign for the newlyweds.Although a Bridge Day wedding isn't the traditional kind of wedding, Patrick Steiner said it was perfect for the easy-going pair."The last few months, we've been to quite a few weddings and the common theme in planning their wedding is that it was extremely stressful," Patrick Steiner said. "Although this wedding is stressful at times, it's been easier. We wanted something carefree and enjoyable to start our lives together, and this has given it to us."No major injuries were reported Saturday, but three people were transported to area hospitals with minor injuries.To learn more about Bridge Day visit http://www.officialbridgeday.com.Reach Megan Workman at firstname.lastname@example.com or 304-348-5113.
U.S. District Judge Gina Groh effects 'a fair shot'
W.Va. Supreme Court to hear Lavigne case Tuesday


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Opportunities in Computer Science
Academic Opportunities
Summer Research Opportunities
Current Grinnell College students will find a list of research opportunities on the Science Division GrinnellShare site (login required). You will find descriptions for research projects with professors on campus, as well as a number of off-campus opportunities. Inclusion in the list does not constitute endorsement by Grinnell College or its faculty/staff. There is also a list of Summer research opportunities maintained by the Computer Science Department.
Noyce/Intel Internship
The goal of this program is to offer students educational experience in applied technology; essentially, seeking to blend idealism with realism. To qualify, eligible students must demonstrate that the internship they propose will: focus on applied science or technology; emphasize application over discovery; take place in a non-profit or government setting in the United States; and achieve problem-solving goals.
For more information, please contact the program chair, Samuel Rebelsky.
Gates Cambridge Scholarships
Gates Cambridge Scholarships are highly competitive full-cost awards for full-time graduate study and research in any subject available at the University of Cambridge.
More information: http://www.gatescambridge.org/
Application: http://www.gatescambridge.org/apply/
Google Anita Borg Memorial Scholarship
Anita Borg Scholarships provides female undergraduates and graduates majoring in computer science, computer engineering, or a closely related technical field with $10,000, an invitation to attend the Annual Google Scholars' Retreat, and participation in a unique program that includes professional development.
More information: http://www.google.com/anitaborg/us/
Application: https://google.eresources.com/applications/default.asp?mode=select
Marshall Scholarships
Marshall Scholarships finance young Americans of high ability to study for a degree in the United Kingdom. Up to forty Scholars are selected each year to study at graduate level at an UK institution in any field of study.
More information: http://www.marshallscholarship.org/
Application: http://www.marshallscholarship.org/applications/apply
Mitchell Scholarship
The Mitchell Scholarship Program, named to honor former US Senator George Mitchell's pivotal contribution to the Northern Ireland peace process, is designed to introduce and connect generations of future American leaders to the island of Ireland, while recognizing and fostering intellectual achievement, leadership, and a commitment to community and public service.
Up to twelve Mitchell Scholars between the ages of 18 and 30 are chosen annually for one year of postgraduate study in any discipline offered by institutions of higher learning in Ireland and Northern Ireland.
More information: http://www.us-irelandalliance.org/content/3/en/George%20Mitchell%20Scholarship%20Program%20|%20US-Ireland%20Alliance.html
Application: http://www.us-irelandalliance.org/content/43/en/Applying%20to%20the%20George%20Mitchell%20Scholarship%20Program.html
Rhodes Scholarships
Rhodes Scholarships, the oldest international educational fellowships, were initiated after the death of Cecil Rhodes in 1902, and bring outstanding students from many countries around the world to the University of Oxford.
More information: http://www.rhodesscholar.org/
Application: http://www.rhodesscholar.org/applying-for-the-scholarship/
Activities and Organizations
The Student Educational Policy Committee, or SEPC, is a student-faculty liaison group which provides faculty with student input on professors, candidates, curriculum, and other departmental issues. It also organizes social events within the department. Email sepc-cs[at]grinnell[dot]edu for more information.
CS Table
Grinnell College's CS Table is a weekly gathering of folks on campus (students, faculty, staff, alums, etc.) to talk about issues relating to computer science. All are welcome, although computer science students and faculty are particularly encouraged to attend. For more information, please contact Professor Samuel A. Rebelsky.
Thursday Extras
Thursday Extras is a series of occasional talks organized and sponsored by the Department of Computer Science. We invite everyone in the Grinnell College community to attend! Join us before the talk for refreshments and conversation by a student, faculty member, or visitor.
The faculty sponsor and organizer of the group is John Stone. If you're interested in presenting a Thursday Extra, send an email or drop in at his office (Science 3829). He also maintains a tentative and open schedule for future talks in the series.
Department Picnics
The department organizes a fall and spring picnic, often held in cooperation with the Department of Mathematics and Statistics, to help create a sense of community among computing students and faculty.
AppDev Team
The Grinnell AppDev Team is a group of students striving to develop quality apps for campus and community benefit. For more information, email appdev[at]grinnell[dot]edu.

subset: commoncrawl


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Harris keeps spot in Wallabies team
Goalkicking ace Mike Harris held out a fit Berrick Barnes to keep his place at fullback for the Wallabies' European tour opener against France in Paris on Sunday.
Barnes, who hasn't played since puncturing his lung in the September 30 loss to South Africa in Pretoria, has been included on the bench as coach Robbie Deans named the same backline that ran out against New Zealand in Brisbane last month.
Harris kicked six penalty goals that night in Australia's 18-18 draw with the All Blacks.
Deans made three changes to his forward pack with tighthead prop Sekope Kepu, blindside flanker Dave Dennis and second-rower Kane Douglas all getting starts in the Nathan Sharpe-led side.
Kepu comes in for James Slipper while Dennis replaces the suspended Scott Higginbotham at No.6 and Douglas in for the injured Sitaleki Timani (hamstring).Veteran Stephen Moore returns to action off the bench after overcoming a hamstring injury while rookie prop Paddy Ryan is also on the pine.
As expected, champion flanker David Pocock wasn't selected but has trained strongly and is on track to face England at Twickenham on Saturday week.
Flying winger Digby Ioane was given every chance to prove his fitness this week as he continues his comeback from a knee injury but he hasn't quite measured up.
Drew Mitchell is another Wallaby on the comeback trail who has trained well in France this week and he's expected to feature in the tour soon.
Wallabies team:Mike Harris, Adam Ashley-Cooper, Ben Tapuai, Pat McCabe, Nick Cummins, Kurtley Beale, Nick Phipps, Wycliff Palu, Michael Hooper, Dave Dennis, Kane Douglas, Nathan Sharpe (capt), Sekope Kepu, Tatafu Polota-Nau, Benn Robinson. Res: Stephen Moore, James Slipper, Paddy Ryan, Rob Simmons, Radike Samo, Liam Gill, Brett Sheehan, Berrick Barnes.
(Live Matches)


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The Emily and Meritt Bunny Table Lamp & Shade
- Overview
Hop right to it with this brass bunny lamp, perfect as a reading light on your bedside table. It's smartly topped with a casual denim shade. This Brass Bunny Table Lamp is designed exclusively for PBteen by celebrity stylists and fashion designers Emily Current and Meritt Elliott.
- Lamp base is crafted of steel and poly resin , finished in antique brass.
- Shade is crafted of denim.
- On/off switch is located on the socket.
- Lamp base and shade are sold as a set.
- Bulb (1): 60 watts, type A (CFL bulb included)
- UL-listed.
- Imported.
- Title 20 compliant lamps will be shipped to CA addresses. Learn more to understand product differences.
California Title 20 compliant lamps will only be shipped to California addresses. If you're shipping to a California address, please make sure you select the lamp base marked CFL. Learn More about California Title 20.
- Dimensions + Care
- Overall: 10.25" diameter, 22.75" high
- Base: 7.25" diameter, 22.75" high
- Shade: 9" diameter at top, 10.25" diameter at bottom, 9" high
- Harp: 8" high
- Finial: 0.75" diameter
- Bulb (1): 60 watts, type A (CFL bulb included); CFL bulb included for Title 20 compliant lamps
- Cord: 7.5' long
- Weight: 8 pounds
- Wipe clean using a soft, dry cloth.
- Avoid using harsh chemicals and abrasives as they may damage the finish.
- Do not exceed specified wattage.
- Shipping Info
This item will arrive in 3-5 business days. Please proceed to the Payment & Review page of Checkout for a precise delivery estimate.


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Click Here for More Articles on LES MISERABLES EVOLUTION OF THE REVOLUTION
BWW Blog: 'Evolution of the Revolution' - Love the Book
We're very excited to kick off our content series launch for the hit new revival of LES MISERABLES, revealing exclusive content from LES MISERABLES - EVOLUTION OF THE REVOLUTION. The new web site, located at http://evolutionoftherevolution.net/, is hosting all sorts of content about the musical with sections about the music, physical world, inspiration, cultural impact, and lots more from polls to artworks. Basically, it's all things LES MIZ!
Check out the photo below!
Submit your LES MIZ fan art, photos and videos on your social media using #EvoOfTheRevo for the chance to be featured on Evolution of the Revolution!
For more information, visit: http://evolutionoftherevolution.net/
Related Articles
From This Author Guest Blogger: LES MIZ


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Topic: Updates to Website
If you have been looking through the website today you will notice that Rick has been hard at work getting the "coming soon" pages updated. We welcome and appreciate your insights and additions, links to any sites that have been helpful to you in your journey will be helpful to others.
We've had several suggestions that we love, but are not yet able to accomodate, but we will.
We will be updating the foundation information as well.
Thanks to everyone who has been so patient. As this site has developed slowly over the last two years, our hearts have grown to bursting as we have watched you reach out and help each other. That was the dream from the beginning.
Much love to you,


text: Food Notes: Feb. 6, 2013 By Julie Robinson February 5, 2013 Story Share Culinary OlympicsCHARLESTON, W.Va. -- Bocuse d'Or Team USU, headed by The Greenbrier's Executive Chef Richard Rosendale placed seventh place out of 24 countries competing last week in the Bocuse d'Or in Lyon, France. Rosendale and his assistant Corey Siegel trained for a year for the culinary competition, considered the Olympics of the culinary world.Each team had almost six hours to prepare an exquisite meat dish featuring Irish beef tenderloin and fish dish containing European blue lobster and turbot. France, Denmark and Japan took gold, silver and bronze honors.Rosendale developed his creations with an eye toward Appalachian influences. For the fish entrée, he poached and glazed the turbot with au jus and used cider-poached butternut squash, lobster mousse with cider, Virginia ham, black truffles and wild mushrooms. His beef dish was a twist on pot roast with asparagus, potato dumplings infused with beef broth and roasted carrots.Team USA's best finish in the Bocuse d'Or finish was sixth place in 2011.Cast Iron Cook-Off resultsThe Cast Iron Cook-Off, a culinary event that pairs teams led by chefs from all over the region who create dishes that best represent Appalachia was held Saturday at The Greenbrier.This year organizers added a new category, as they did last year with a Throw Down that pitted the three top winners from the previous year's competition in a timed event and presentation. This year's Throw Down winning team was from Mountwest Community and Technical College in Huntington led by chef Isabel Cross.The event introduced teams from neighboring states into the competition. Charleston native William Dissen, chef at The Marketplace Restaurant in Asheville, N.C., won the competition over chefs from West Virginia, North Carolina and Virginia.The Cast Iron Cook-Off Winners:Overall Champion: Pierpont Culinary in Fairmont Best Menu: Pierpont Culinary in FairmontBest Single Course: Greenbrier Golf Classic in White Sulphur SpringsBest Use of Cast Iron: Tie between The Bank Food and Drink in Pearisburg, Va., and Panorama at the Peak in Berkeley SpringsTable Presentation: Diogis in Fayetteville Best Teamwork: Diogis in FayettevilleWhistle while you work: Panorama at the Peak in Berkeley Springs Best Use of Appalachian Produce: Laurel Vista Farm in Somerset County, Pa.Best Use of Protein: WV Generations in MartinsburgThe People's Choice Award: Bank Food and Drink in PearisburgValentine wine event The Liquor Company will hold A Private Affair to Remember from 6 to 8 p.m. today featuring wines and foods by D'Artangnan Event Culinary Designs. The menu features French creations such as roasted lamb and pine nut popovers crimini duxelle and lobster and veal roulade lemon butter marmalade in a six-course, wine-paired meal. Cost is $50. Reservations required. Call 304-346-6000.Mardi GrasSt. Mark's Episcopal Church in St. Albans will host a Mardi Gras celebration featuring Cajun food from 11 a.m. to 3 p.m. Saturday. The menu includes pork barbecue, king cake, pecan pies and other baked goods, in addition to Cajun food.Belated Fat Tuesday FarePullman Plaza Hotel in Huntington will celebrate Fat Tuesday at 6:30 p.m. Feb. 15. The six-course, wine-paired dinner features a large assortment of Cajun and Creole foods for $75. Reservations required. Call 304-691-5414.Chef's ChallengeChef's Challenge Benefit Dinner to benefit Covenant House will be held March 27 at the Culture Center's Great Hall. Chefs Jeremy Still of Edgewood Country Club, Joe Zando of Catering Unlimited and Tim Urbanic of Café Cimino Country Inn in Sutton will create a gourmet meal for 200 people using food typically found in a food pantry.Tickets are $100 per person. Call 304-344-8053, extension 22, for tickets, which are available in advance only.Reach Julie Robinson at email@example.com or 304-348-1230 with information to be included in Food Notes. Story Share Story Share Trending Now 1 Facebook founder visits Charleston restaurant 2 Gazette editorial: Capito has second chance to do the right thing 3 Rod Run and Doo Wop brings classic cars, music to Boulevard for 12th year 4 Parole hearing set for Putnam man who claims wrongful sex assault conviction 5 Former State Police captain now chief in Winfield Charleston native recruits best and brightest to Navy Previous Story Traditional meal on Fat Tuesday features pancakes Next Story


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Drumming under water
Well, here I am in Queensland (the Sunshine State), and three quarters of the state have been declared a disaster area. The recent floods are the worst natural disaster in Australia's history (in extent, not in terms of loss of life fortunately).
Queensland is a large state. To give you an idea how large, take Colorado, Kansas, New Mexico, Texas, Oklahoma, and Louisiana. All together, they are not quite as large as Queensland. You need to add Massachusetts and Connecticut to make up the difference. Or, if you want to put it differently, Queensland is has almost exactly 20% of the land area of the entire United States. Three quarters of that are flooded or severely affected by flood.
Queensland has experienced very serious losses of crops and livestock. Infrastructure is seriously damaged everywhere. Roads, bridges, water supply, electricity, communications, etc. It is difficult to ensure supply of essential goods to many areas that are cut off by the floods. Supermarkets are low or empty of fruit and vegetables in many areas and there is no milk or eggs, bottled water, and very little meat. The Brisbane markets, which are the central supply point for much of Queensland, are flooded and out of action, so the supply chain will continue to be strained for quite some time to come.
So far, thirteen people are confirmed dead after the flash floods in Toowoomba and the Lockyer valley. Entire towns have been completely wiped out in the Lockyer valley. By "wiped out", I mean just that. Houses have been carried hundreds of meters down-stream by the flood; where the flood went through, almost nothing is left standing. Around 70 people are still unaccounted for, and the fear is that many of them will have died.
In Brisbane, the peak of the flood occurred at 4:00am this morning, at 4.5 meters, which, fortunately, is one meter shy of the '74 flood. At the moment, flood waters are down by about a foot but will rise again to around 4.5 meters this afternoon with the high tide. Around 20,000 homes and businesses are flooded. 116,000 people are without electricity. The Brisbane river is a raging torrent, hundreds of meters wide in many places.
Unfortunately, the venue where we do our drum and dance lessons was flooded. At the moment, there are three feet of water in the place. So much for the wooden dance floor, the mirror wall, kitchen, sales counter, etc. At least I was proactive enough to go there two days ago and rescue my dunduns, which would have been history otherwise. It'll be days before the water will recede, and weeks for the building to dry out. There is no way that we will be teaching in that space again for the next few weeks at least. We are currently looking for a temporary venue to hold our classes starting on 29 January.
On a personal level, I am not directly affected by the floods—my house is 86 meters above sea level and nowhere near the flooded areas. Linda and Yenenesh (my co-teachers) are also OK. At this point, we have no idea how our students have fared. We fear that many of them will be affected. We have a bunch of people in our classes from Ipswich (40km from Brisbane), which is another complete disaster area, with much of the city center under water. And many of our students live in West End, one of the worst affected suburbs (which is also where we are teaching), so at least some of them will almost certainly have suffered.
Economically, no-one has any idea yet of the total damage. But it will be in the tens of billions easily. Tough times ahead for many people
6 Comments Viewed 200263 times
Re: Drumming under water
Good God. My thoughts are with you.
West African Drum & Dance Classes in Westchester, NY
Please send me a PM if you would like to be on my email list!
Re: Drumming under water
Yikes, sounds hardcore. I hope Queensland can pull through this disaster...
Re: Drumming under water
Hey, keep the spirits high and hope the best for all of you. I can feel you guys, I have been through 2 hurricanes here and its very devastating.
But don;t forget, there more tu tu ta ta to come in life.
If you want to see me kick some butt, just tell me about all the things you think I won't be able to do
Re: Drumming under water
best of luck michi!!!
good thing you saved your dununs!!
should i shave my moustache?
Re: Drumming under water
Been catching up on things.... this sounds devastating. I hope for the best for you and your family and friends. Glad to hear that you are safe.
I'm afraid that severe flooding is becoming more common due to the global climate crisis. As the polar ice caps melt away, sea levels and water tables rise. Places that were once safe from floods are now at risk. Countries like the U.S. and China, who are huge polluters, are most at fault due to the inaction of those governments. It's sad; even though many individuals take great care to reduce waste and fuel consumption in their daily lives, the problem continues to grow because our government refuses to enact limits and penalties on industrial polluters.
"If you knock long enough, eventually the door will open."
Tasumakan - Djembe and Dunun Video Lessons
Re: Drumming under water
The increasing average temperatures mean that the atmosphere can hold more moisture, which means that heavy precipitation events will continue to get worse. A recent study has confirmed this trend over the past 50 years.
But the real problem is that there are too many people on this planet. The world's population has more than tripled in my lifetime...
Last edited by michi on Tue Jan 01, 2013 6:54 am, edited 1 time in total.
6 replies • Page 1 of 1
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Any of you folks live in the Cruz area?
I'm flying out from CO to get my De La cherry popped.
Obviously stoked to be playing one of the more storied courses in the world.
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plastic_fondler wrote:players pack for master's cup has always been quite nice. The am and pro events will share the same player's pack main item, but in different colors per weekend. I don't know what it will be...but always usable. I still think the umbrella we got a few years ago is the nicest players pack item I've gotten from a pdga event.
WesV wrote:I live in the Cruz. You're in for a treat, the course is beautiful right now. Definitely set up nice and chellenging.
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Dose Response of 28 Days of Dosing of GSK962040 in Type I and II Diabetic Male and Female Subjects With Gastroparesis
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
GSK962040 is a novel small molecule motilin agonist. The Phase I studies (MOT107043 and MOT109681) demonstrated that single doses of GSK962040 up to 150 mg and repeat dosing of up to 125 mg/day for 14 days were well tolerated with adverse events not occurring in greater prevalence than placebo, and no significant abnormal vital sign, ECG, or clinical laboratory findings. Pharmacokinetic parameters were linear and approximately dose proportional over the range of doses administered. Single doses of 50 mg - 150 mg GSK962040 significantly increased the rate of gastric emptying up to 40% as measured by the 13C octanoic acid stable isotope breath test. A similar effect of 50 mg and 125 mg on gastric emptying was observed throughout repeated dosing to healthy volunteers for 14-days.
The aims of the present investigation (MOT114479) are to assess the pharmacodynamic effects (gastric emptying and symptoms), safety, tolerability, and pharmacokinetics of GSK962040 after 28 days of once-daily dosing in Type I and Type II diabetic subjects with gastroparesis. An additional aim is to characterize the dose/exposure - pharmacodynamic effect relationship.
|Drug: GSK962040 (5 mg tablet) Drug: GSK962040 (25 mg tablet) Drug: GSK962040 (125 mg tablet) Drug: Placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Randomized, Double-Blind, Placebo-Controlled Multicenter Phase II Study to Evaluate the Safety and Efficacy and Dose Response of 28 Days of Once-Daily Dosing of the Oral Motilin Receptor Agonist GSK962040, in Type I and II Diabetic Male and Female Subjects With Gastroparesis
- Gastric emptying, as measured by the 13C-oal breath test [ Time Frame: 28 days ]
- Gastric half emptying time [ Time Frame: 28 days ]
- Adverse Events (AEs) [ Time Frame: 28 days ]
- cardiovascular parameters (12-lead ECG, heart rate, blood pressure) [ Time Frame: 28 days ]
- clinical chemistry and hematology parameters [ Time Frame: 28 days ]
- Population pharmacokinetic parameters of GSK962040: Cmax, Tmax, AUC(0-t), Ct, CL/F, V/F, and, if possible, half-life [ Time Frame: 28 days ]
- Time to first bowel movement after first dose [ Time Frame: 28 days ]
- daily bowel movement frequency [ Time Frame: 28 days ]
- daily average stool consistency [ Time Frame: 28 days ]
- change in GI symptoms [ Time Frame: 28 days ]
|Study Start Date:
|May 2011
|Study Completion Date:
|February 2013
|Primary Completion Date:
|February 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: GSK962040 (10 mg)
GSK962040 10 mg
Drug: GSK962040 (5 mg tablet)
5 mg tablet
Experimental: GSK962040 (50 mg)
GSK962040 50 mg
Drug: GSK962040 (25 mg tablet)
25 mg tablet
Experimental: GSK962040 (125 mg)
GSK962040 125 mg
Drug: GSK962040 (125 mg tablet)
125 mg tablet
Experimental: Placebo
Drug: GSK962040 (5 mg tablet)
5 mg tabletDrug: GSK962040 (25 mg tablet)
25 mg tabletDrug: GSK962040 (125 mg tablet)
125 mg tabletDrug: Placebo
matching placebo tablet
|Ages Eligible for Study:
|18 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Type I or II Diabetes Mellitus (HbA1C < 10%)
- Male or female between 18 and 80 years of age, inclusive.
- Patient has gastroparesis at screening (gastric half-time of emptying > upper limit of normal as determined by 13C-oral breath test)
- Patient must have a > or = 3 month history of relevant symptoms of gastroparesis (e.g., chronic post-prandial fullness, early satiety, postprandial nausea), patients will have a mean of the daily scores over a minimum of 7 days indicating > or = mild (2) and < or = severe (4) post-prandial fullness assessed using the GCSI-DD during the screening period prior to randomization.
- A female patient is eligible to participate if she is of: Non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea [in questionable cases a blood sample with simultaneous follicle stimulating hormone (FSH) > 40 MlU/mL, or a value consistent with the local laboratory standard value, is confirmatory. OR Child-bearing potential and agrees to use one of the contraception methods listed in Section 8.1 for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female patients must agree to use contraception for at least 5 days following the last dose of study medication.
- Male patients must agree to use one of the contraception methods listed in Section 8.1. This criterion must be followed from the time of the first dose of study medication through at least 5 days after the last dose of study medication.
- BMI >18 and < or = 35.0 kg/m2 (inclusive).
- Patient has never had a gastrectomy, nor major gastric surgical procedure or any evidence of bowel obstruction or strictures within the previous 12 months
- Dosage of any concomitant medications has been stable for at least 3 weeks, except for routine adjustments in daily insulin treatments.
- Estimated (or measured) glomerular filtration rate > or = 30 mL/min.
- QTcB or QTcF < 450 msec or QTc < 480 msec in patients with Bundle Branch Block based on single or average QTc value of triplicate values obtained over a brief recording period.
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form.
- AST and ALT < 2xULN; alkaline phosphatase and bilirubin < or = 1.5xULN (isolated bilirubin >1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).
Exclusion Criteria:
- Patient has acute severe gastroenteritis
- Patient has a gastric pacemaker
- Patient is on chronic parenteral feeding
- Patient has pronounced dehydration
- Recent (last 6 weeks) history of poor control of diabetes e.g. hypoglycaemia requiring medical intervention, diabetic ketoacidosis, admission for control diabetes or complications of diabetes
- Patient has evidence of severe cardiovascular autonomic neuropathy (e.g. history of recurrent syncope in the last 6 months)
- Patient has a history of eating disorders (anorexia nervosa, binge eating, bulimia)
- Use of medications potentially influencing upper gastrointestinal motility or appetite within one week of the study (e.g., prokinetic drugs, macrolide antibiotics (erythromycin), GLP-1 mimetics)
- Regular opiate use
- Use of prohibited medications listed in Section 9.2 within the restricted timeframe relative to the first dose of study medication.
- History or presence of clinically significant gastro-intestinal, hepatic or renal disease or other condition that would in the opinion of the investigator or medical monitor make the subject unsuitable for inclusion in this clinical study.
- The patient has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer).
- History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation.
- Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day time-period.
- Pregnant females as determined by positive serum or urine hCG test (from the first urine of the day) at screening or prior to dosing.
- Lactating females.
- Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening
Please refer to this study by its ClinicalTrials.gov identifier: NCT01262898
Show 24 Study Locations
|Study Director:
|GSK Clinical Trials
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01262898 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 16, 2010
|Last Updated:
|April 27, 2015
Keywords provided by GlaxoSmithKline:
13 C oral breath test
gut motility
repeat dose
phase II
Type I and II Diabetes mellitus
gastric emptying
Additional relevant MeSH terms:
Stomach Diseases
Gastrointestinal Diseases
Digestive System Diseases
Neurologic Manifestations
Signs and Symptoms
ClinicalTrials.gov processed this record on September 21, 2017


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Andrew Smith (Biology) with student co-authors get published!
Contributed by Nancy Pierce on 03/28/13
M. Braun (Biology '11), M. Menges (Biology '10), F. Opoku (Biochemistry '13) and A. M. Smith. 2013. The relative contribution of calcium, zinc and oxidation-based cross-links to the stiffness of Arion subfuscus glue. The Journal of Experimental Biology 216, 1475-148. View the article here.
Metal ions are present in many different biological materials, and are capable of forming strong cross-links in aqueous environments. The relative contribution of different metal-based cross-links was measured in the defensive glue produced by the terrestrial slug Arion subfuscus. This glue contains calcium, zinc, manganese, iron and copper. These metals are essential to the integrity of the glue and to gel stiffening. Removal of all metals caused at least a fifteen-fold decrease in the storage modulus of the glue. Selectively disrupting cross-links involving hard Lewis acids such as calcium weakened the glue, while disrupting cross-links involving borderline Lewis acids such as zinc did not. Calcium is the most common cation bound to the glue (40 mmol L-1), and its charge is balanced primarily by sulfate at 82 to 84 mmol L-1. Thus, these ions likely play a primary role in bringing polymers together directly. Imine bonds formed as a result of protein oxidation also contribute substantially to the strength of the glue. Disrupting these bonds with hydroxylamine caused a 33% decrease in storage modulus of the glue, while stabilizing them by reduction with sodium borohydride increased the storage modulus by 40%. Thus, a combination of metal-based bonds operates in this glue. Most likely, cross-links directly involving calcium play a primary role in bringing together and stabilizing the polymer network, followed by imine bond formation and possible iron coordination.
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FY 2013 Third Quarter
FY 2013 Third Quarter Fund Statements and Summary of Capital Projects
On March 5, 2013, the County Executive presented the FY 2013 Third Quarter Review package to the Board of Supervisors. This package includes Supplemental Appropriation Resolution AS 13227 and Amendment to the Fiscal Planning Resolution AS 13901 which includes the revenue, expenditure and transfer adjustments and grant awards and adjustments and associated reserve adjustments contained in the County and School's Third Quarter Review and Supplemental Appropriation Resolution AS 12147 which reflects final FY 2012 audit adjustments. The Board will approve the FY 2013 Third Quarter Review on April 23, 2013.
If you have questions about the FY 2013 Third Quarter Review, please contact the Department of Management and Budget (DMB) Third Quarter Coordinator, Mike Franks, at 703-324-2309.


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Oneself, indeed, is one's saviour, for what other saviour would there be? With oneself well controlled one obtains a saviour difficult to find.
By oneself alone is evil done; it is self-born, it is self-caused. Evil grinds the unwise as a diamond grinds a hard gem.
From SN 45:
http://www.accesstoinsight.org/tipitaka ... .than.html
Admirable friendship... is actually the whole of the holy life. When a monk has admirable people as friends... he can be expected to develop & pursue the Noble Eightfold Path.
How can these both be true? Is morality purified by one's own effort, or by the external environment (by having the right social connections, the right friendship, birth in the right society)?


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Juan Manuel Marquez was asked to recall his thoughts when the scorecards were read for his third fight with Manny Pacquiao on Nov. 12, 2011 at MGM Grand in Las Vegas.
As he was answering, it was easy to detect his anguish.
"Deception, sadness," said Marquez, who appeared to have finally beaten Pacquiao, only to hear the judges score Pacquiao the majority-decision winner. "I felt angry because when they were reading the scorecards, the scorecards were read for him. But I knew I won the fight."
Not only did Marquez know in his heart he won, he believes anyone who saw it had to have him winning as well.
"Without a doubt, the last fight I thought I won clearly," he said. "Everyone thought I won the fight. The only people that didn't think that I won the fight were the judges."
Mexico's Marquez (54-6-1, 39 KOs) on Saturday will get a fourth shot at Pacquiao, of the Philippines, when they square off in the welterweight main event at MGM Grand (on HBO pay-per-view). There is no major belt on the line, but in this series it really doesn't matter because of all the controversy surrounding the three decisions.
In their first fight in May 2004, Marquez miraculously got up from three first-round knockdowns to earn a draw. Marquez thought he won, but a draw seemed fair. In their second go-round in March 2008, Pacquiao won a split-decision. Marquez and his camp moaned so much in the post-fight news conference, it was shameful and embarrassing for the sport.
After all, it was a close fight.
Then came the third fight, which was deemed questionable by many of the dozen or so veteran reporters polled afterward. Not one had Pacquiao winning, though two scored it a draw.
Marquez's trainer, Nacho Beristain, couldn't believe it.
"This was robbery of the utmost," he said at the time.
Bob Arum promotes Pacquiao (54-4-2, 38 KOs), his cash cow.
"Oh, it was a close fight," Arum said Wednesday. "If it had been scored as close for Marquez as it was for Pacquiao, nobody could complain. It was a very, very close fight."
One thing's for sure, Pacquiao and his trainer, Freddie Roach, have grown very tired of all of Marquez's bellyaching. Pacquiao, normally a guy who never rips anyone, went out of character during a Monday telephone conversation.
"He (Marquez) is always complaining and complaining and it's not good for a champion like that to complain," Pacquiao, 33, said from the Wild Card Gym in Hollywood, not long before he hopped aboard his bus to Las Vegas. "I never like to complain, and that's why there is a fourth fight."
Pacquiao reminded a reporter how he acted after his most recent fight, a highly controversial split-decision loss to Timothy Bradley in June at MGM Grand. Just like it was virtually impossible to find a reporter who had Pacquiao winning his third fight with Marquez, there were none polled who had Bradley beating Pacquiao.
"If we compare the last fight we had with Marquez and the fight I had with Bradley, it was a very one-sided fight with Bradley, but they never hear from my mouth that I'm complaining," Pacquiao said. "I respect the decisions of the judges."
Said Roach: "Manny is not like that. But the thing is the three fights they have had, you take a counterpuncher against an aggressive fighter, you're going to have close rounds. The close rounds are always going to go to the aggressive guy and that is Manny Pacquiao.
"That is why Manny Pacquiao has won all three fights. I thought we won all three fights.
"The last one we got booed afterward because the Latin Grammys were there the night before and we were outnumbered. But if one of those three fights had gone the other way, I wouldn't have cried."
That's why, Roach said, "I do want to shut them up," meaning Marquez and Beristain.
Marquez, 39, has had a tremendous career that will one day land him in the International Boxing Hall of Fame. But riding off into the sunset without a win over Pacquiao would be hard for him to take.
"Very, very important," Marquez said, when asked how vital it is for him to get that win. "I have this opportunity and the victory will be mine and I will be able to retire with a victory over Manny Pacquiao."
Only if the judges say so, and so far that has not been the case.


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ST. LOUIS—Pittsburgh Pirates right fielder Josh Harrison, who started Tuesday's game at Busch Stadium on the bench, was part of a game-saving double play in the 11th inning—as a fifth infielder stationed at second base.
Not playing the second base position, mind you, but standing almost on top of the bag when the pitch was thrown.
St. Louis reliever Seth Maness hit into that double play—the Cards were out of position players as potential pinch hitters by that point—and then induced a game-saving double play on the mound with the bases loaded and one out in the Pirates' half of the 13th inning. Maness had never pitched in extra innings before in his professional career; on Tuesday, he threw 2 1/3 scoreless frames after regulation. "That was exciting," Maness said with a smile.
MORE: Reds' bullpen saves the day | Goldy walks it off in 11th | ChiSox edge Tigers in 11
It was that kind of night. At one point, with the Pirates batting in the 11th, the crowd started whistling loudly, en masse, for no apparent reason.
Just because, it seemed.
By the time the game ended on a single by Cardinals reserve outfielder Adron Chambers in the 14th, after almost five full hours of baseball (4:55 to be exact), the end was welcomed. For Chambers, it was only the second-most memorable game he's been a part of with the Cardinals. "It's Game 6 of the (2011) World Series," he said of the most memorable. "You set your standards high and work on down. This was a great moment for me. I've never had a walkoff hit before. So that was perfect for me."
MORE: Tuesday results | Wednesday games | Standings | Stats | Fantasy Source
There were cringe-worthy moments aplenty in extra innings, for both teams, which you wouldn't expect in a game between the top two squads in the National League Central. The Cardinals cut the Pirates' lead in the division to just two games with the 4-3 victory.
The craziness really started in the ninth inning, when Pirates left fielder Starling Marte dropped a lazy fly ball from Daniel Descalso. Running the whole way, Descalso wound up on second base and later scored on a two-out single by Allen Craig. That hit, a line drive into right field, boosted Craig's batting average with runners in scoring position and two outs to an insane .471 this season (24-for-51), but Carlos Beltran was thrown out trying to advance from first to third on the play.
The Cardinals had a chance to win in the 10th, but questionable bunting strategy by manager Mike Matheny led to a goose egg on the scoreboard. With two runners on and no outs—and Rob Johnson, the backup catcher, was on base only because Pirates first baseman Gaby Sanchez made a poor throw when Johnson tried to sacrifice Matt Holliday to second—Matheny had John Jay lay down another sacrifice bunt to move pinch runner Joe Kelly—one of the Cardinals' starting pitchers—to third base with one out.
The problem with bunting there: Jay already had three hits in the game to run his average in August to a scintillating .396, and the Pirates were obviously going to walk the next batter, Chambers, to set up a forceout at any bag and a potential double play.
After Chambers was walked, up came shortstop Pete Kozma, who had just 16 hits in his previous 95 at-bats (a .168 average). He couldn't put the ball in play, striking out against reliever Vin Mazzaro. Descalso then flied out to end the threat.
The Cardinals' 11th inning ended with that 6-9-3 double play that Harrison definitely didn't expect to be a part of hours earlier. And Maness came up again in the 13th, after the Pirates walked Beltran and Craig intentionally to load the bases. This time, he struck out looking. He'd had just two at-bats all season entering the game, and then had two at-bats in extra innings Tuesday.
Yep. That kind of day.


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Greetings all,
I have been perusing this site for many years as i've struggled with coming to terms with my epilepsy. I finally, this morning, am breaking down and attempting to post a topic of discussion of my own. I've noticed much comaraderie, good advice, and helping others on here which is commendable.
The funny thing is all of that also makes me mad.
In addition, the doctors giving their advice to take medications, my co-workers discussing regular person life issues, and loved ones trying to take care of me ... pardon my french, pute them!
You know what does bring me pleasure though? Stories of people doing things to get themselves in trouble. Also, doing bad things and getting away with them. I like to remember a time before my epilepsy when that was me. I was not a perfect person then and i do not pretend to portray myself as one now.
Anyone else have these feelings? Of course without going counter to the goals of this great site, but do any of you have any stories of things you did "back in the day" which may not have been exactly in line with the lives that Gandhi or Mother Teresa lived?


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Simmons latest Braves regular to get a night off
ATLANTA -- As catcher Evan Gattis returned to the Braves' starting lineup, Andrelton Simmons received the night off on Thursday. Ramiro Pena started as shortstop and batted eighth in place of Simmons.
Simmons entered Thursday having played in 48 of Atlanta's past 49 games, and his 866 1/3 innings played this year rank third on the team. Gattis' return to the lineup falls in line with Braves manager Fredi Gonzalez's plan to give him a day off once every few days.
"Going forward, we'll do that like we did at the beginning of the year," Gonzalez said. "Just keep him healthy, keep him fresh."
Meanwhile, reliever Anthony Varvaro will spend a second day on the paternity list. Atlanta has not yet received word if his wife has given birth yet, but Varvaro is allowed up to three days off for paternity leave.
"I'm hoping everything is good, but I haven't heard if the baby was delivered or anything," Gonzalez said. "I haven't even heard that. I know he's not here. He mentioned to me that today would have been the day."
Joe Morgan is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Native to Australia and second to the ostrich in size, an emu in full stride is a spectacular sight. Reaching speeds around fifty kilometres (30 miles) per hour, emus run confidently through the Australian bushland, superbly built for such speed and agility.
The indigenous rock art at Gundabooka shows several emus with their three prominent toes, highlighting the importance of the statuesque bird as a source of food and feathers.
This photo is from the driver's car window in remote Gundabooka National Park. Trying to time the gaps between the roadside trees and keep the car in a straight line, this photo gives some impression of the speed and agility which emus move.
The females lay deep green eggs around the size of a human hand. In a reversal from most of the animal kingdom, the females woo the males. After partnering, the males sit on the eggs while the females leave and partner a second and even third time laying another clutch of eggs.


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Summary: The General Manager of Media will own the strategy, growth plan and day-to-day execution of the digital brand media business for Active Network which includes Active.com and Reserve America.com. The GM will drive the optimal media product offering (digital and experiential) and monetization strategy and will partner with the product team, the media strategy team and the sales team to maximize revenue. The GM will manage the Media P+L and will be a key member of the leadership team for the Consumer Products Business Unit.
Specific Responsibilities Include:
- Develop the optimal product portfolio to drive media revenue
o Package all digital and experimental assets from Active Network
o Partner with Product teams to develop new assets
o Work with sales teams to capture best revenue opportunities
- Drive the Go To Market strategy for all media products
o Manage the pricing, distribution and timing of all products
o Work with Media Strategy team to create the right marketing tools and sales training
o Coordinate with Product and Media Ops to ensure deliverability of all products
o Pitch and deliver to Sales Teams, Active GM's and key clients
- Manage the P+L
o Ensure that all revenue goals are exceeded and expense budgets are met
o Manage revenue recognition and executive reporting on a weekly and monthly basis
- Lead the Media team within Active's matrix organization
- Desire to lead and make a difference inside an organization
- High level and broad range of experience in media, must include digital and experiential
- Proven ability to successfully and consistently monetize media as a publisher
- Experience and ability to manage a P+L
|San Francisco, CA
United States
|Web Site:
|10182 Telesis Court
Suite 300
San Diego, CA 92121
United States
|Business Products and Services
Support Active Network with Social Media services
Find more General Manager, Media jobs


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Women's Chockstone Midweight™ Active Pant
Detailshttp://www.mountainhardwear.com/womens-chockstone-midweight-active-pant-OL5877.html OL5877
Durable softshell pant for hiking and technical climbing. For serious climbers, Chockstone Midweight Active Pants are tough, dependable, and slim-cut to move with you on the rockface. They have excellent stretch. In the harness, the two secure zip pockets are easily accessible, and the no-slip cinch belt by Metolius is one-hand adjustable--and it stays adjusted.
$46.98 $95.00
Style# 1535491
product.components.activity: Backpacking / Hiking


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A recent column in a newspaper stated, "Problems with refineries in California is the cause of overnight pump increases." This is the grand-daddy of all lies.
Traditionally pump prices decrease at the end of summer. These price increases across America are a deliberate plan by the oil companies to make President Obama look bad because he wants to stop their Bush tax breaks. That tax increase would grossly aid our economic recovery.
It makes me sick to witness the corruption in our country. No President is in control. Corporate America is in 100-percent control. I guarantee gas prices will plummet immediately after the election. The refineries will make miraculous recoveries.
John Ornellas


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2013 World Series of Poker* in Las Vegas
The World Series of Poker (WSOP)* Main Event is the biggest poker tournament in the world and you can win a prize package now, via online tournaments at PokerStars. The Main Event Passport is the best way to qualify online, with tournaments available in a range of buy-ins that suit players of all levels and bankrolls.
The Main Event Passport prize package is worth thousands of dollars, giving you everything you need to enjoy the trip of a lifetime in Las Vegas**, including:
- $10,000 WSOP* Main Event buy-in
- $3,000 for travel and expenses
PLEASE NOTE: It is your responsibility to register directly with the organizers of the event, and to book all your own travel and accommodation.
How to Qualify
You can choose from a range of satellites that include cash and FPP buy-ins, as well as Steps Sit & Go's. Win a Main Event Passport and you'll be booking your trip and preparing to play for millions of dollars on poker's biggest stage.
To register for a WSOP* satellite, open the PokerStars lobby, click 'Events' and 'Passport'.
For more details on how qualification for the 2013 World Series works, check the Frequently Asked Questions, and also make sure you read the Terms and Conditions relating to this promotion.
What is the World Series of Poker*?
The $10,000 buy-in World Series Main Event, held every year at the Rio Hotel and Casino in Las Vegas, is the biggest tournament in poker. It attracts professional players, celebrities, sports stars, and online qualifiers alike, and anyone can win it. In 2012, Greg Merson took it down, scooping $8,531,853 in cash from a total prize pool of $62,021,200. This year, it could be you.
If you have any questions about World Series qualification, contact mailto:firstname.lastname@example.com.
* World Series of Poker and WSOP are trademarks of Caesars Interactive Entertainment, Inc. or its affiliates (collectively Caesars). Caesars does not sponsor or endorse, and is not associated or affiliated with, PokerStars or its products, services, promotions or tournaments. Any promotion or tournament on this site will not guarantee your seat or ability to register for any WSOP event or any WSOP affiliated event which is at the sole discretion of Caesars.
** Real money play on PokerStars is not allowed while physically located within the United States of America under any circumstances. Players who attempt to play for real money while they are physically located in the USA will lose their playing privileges and/or funds in their account. Further information is available online at /usaplayers/faq/


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Annual Charleston Crab Feed draws in hundreds
CHARLESTON, Ore. -- Hundreds of people from as far away as Ashland and Eugene were in the south coast over the weekend to help out a local organization, and eat a bit of seafood.
More then 900 pounds of fresh crab was served this weekend at the annual Charleston Crab Feed.
Those who waited in line were treated to a half or a whole crab, and all the money went to support the Charleston Visitor's Center for another year.
Organizers say the event gets larger every year.
"This event is the only fundraiser that we have in Charleston to support the visitor's center and other community events that happen in Charleston," said organizer Ruth Barker.
Margery Whitmer volunteers at the event, and says people are coming from all over. "People are coming from Roseburg, Medford, probably from Eugene," she said. "Not only local, but people come from 150 miles because they're making a day of it. They want to get away from the winter doldrums and come to the coast."
Some travel websites have called the crab feed a "must do" event on the south coast.
Two full tour buses brought a group from Ashland for the event.


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NEW YORK ( TheStreet) - Barnes & Noble ( BKS) should spin off its Nook Media unit of e-readers and e-books, fulfilling a strategy the company said it was exploring at the start of 2012, according to a letter sent by an investor to company management on Friday. Rick Schottenfeld, head of investment firm the Schottenfeld Group, said in a letter sent to Barnes & Noble that the company should follow through on a proposal to spin its fast growing Nook business into a separate publicly traded company. The move, Schottenfeld said, would help to the bookseller's strategy and unlock significant shareholder value. A prospective spinoff would also follow through on a plan the company said it was considering in early 2012. In the Friday letter sent to Barnes & Noble chairman Leonard Riggio, Schottenfeld argued that significant stockholder value is trapped within the company's conglomerate structure, which includes a declining but cash flow positive physical bookstore business and, Nook, its fast-growing but money losing digital books and tablet unit. Schottenfeld argued Barnes & Noble's mature and cash generating retail unit isn't a good fit with its high growth Nook business in public markets. A spinoff, he said, would give investors reason to pay higher multiples for Barnes & Noble's combined assets. Meanwhile, the investor also argued investing Barnes & Noble's legacy bookstore cash flow into Nook has been a poor use of the company's liquidity. "Unfortunately, what we are left with today is a dysfunctional business with two divisions that are seemingly at odds with each other," wrote Schottenfeld, in the letter that recommended Barnes & Noble's maximize the free cash flow of its physical book business and return that cash to investors by way of dividends and share repurchases. Schottenfeld characterized Nook as a growth business with risk and reward characteristics for a different type of investor. "These two companies are attractive to two distinct groups of investors," he wrote, of logic of a spinoff. There's already indication Barnes & Noble agrees with the assessment, even if it's unwilling to fully commit to a Nook spinoff. In early January, Barnes & Noble said in fiscal 2011 third quarter earnings it was considering a split of Nook from its physical bookstores business. In May, the company announced it was embarking on a joint venture with Microsoft ( MSFT) on Nook where the tech giant would invest $300 million in the e-reader business and feature a Nook app as part of its recently launched Windows 8 platform. The JV was finalized in October; however, Nook has yet to be spun off into a separate publicly traded company. At the IMN Activist Investor Conference in May, hedge fund Jana Partners said it took an 11% stake in Barnes & Noble on the heels of its consideration to spin Nook into a separate publicly traded company.
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text: 4/08/09 4/07/09 POPSUGAR Fashion Reem Japan Fashion Week: Reem Fall 2009 April 7, 2009 by coutorture 0 Shares Chat with us on Facebook Messenger. Learn what's trending across POPSUGAR. View On One Page Photo 7 of 9 ADVERTISEMENT () Start Slideshow Share This Link Copy What's Your Reaction? Thanks for your reaction Don't forget to share this with your friends! ← Use Arrows Keys → 7 Photo: Japan Fashion Week Organization 0 previous images -22 more images Previous Next Start Slideshow Reem2009 Fall Japan Fashion Week2009 Japan Fashion Week2009 Fall Fashion Week2009 Fashion Week


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Highland Heights, Kentucky
"Your success and happiness lies in you. Resolve to keep happy, and your joy and you shall form an invincible host against difficulties."
— Helen Keller
Renée Human is program director and assistant professor of Media Informatics (MIN) at Northern Kentucky University. She specializes in web and multimedia design and development. With nearly 20 years of industry experience and 14 years of teaching at the college level, Human loves to share her knowledge with the next generation of creative geniuses, and to learn from them as well.
Human found her path when the phone rang one fateful day in 1996 at Presentation Graphics, a service bureau/design firm in Lexington, Kentucky, where she worked. Would anyone be interested in teaching a night class in HTML at the local community college? Although she didn't know anything about the web, she jumped at the chance to share her love of design and development with the next generation. In 2007, she wrote and produced "Macromedia® Dreamweaver® 8 Interactive Movie Tutorials" as a course teaching aid, and she has since worked on a multimillion-dollar National Science Foundation grant, training community college instructors in Kentucky how to teach beginning web courses.
Today, she leads NKU's Media Informatics program, a cutting-edge curriculum featuring a blend of design and development with a communications and entrepreneurial twist. Currently, her favorite curricular topics include responsive web; HTML5, CSS3, JQuery, and Adobe® PhoneGap™ Build™ for app development; and ActionScript® 3.0 for gaming. "Dreamweaver, Flash® Professional, Flash Builder®, and now the Edge suite have kept up with all these topics and make for the best possible classroom experience' and very hirable graduates," Human says.
Human is an academic member of the National Center for Women in Technology (NCWIT). She also is the advisor to three student organizations: the MINjas (Media Informatics students), the StarCraft Club, and the Communication Graduate Students Organization. She is one of the founding organizers of Mashcomm36, an annual 36-hour contest each February that pairs eight businesses with teams of students to solve digital public relations challenges. The winning student teams for two consecutive years have been MINjas, harnessing Adobe products to create their solutions.
She has completed her coursework and qualifying exams toward her PhD. in communication at the University of Kentucky, and is now working on her dissertation. Human's primary areas of research focus on interpersonal use of technology in relationships, education, and in the gaming industry. The notion of community, whether it be offline or online, permeates both her academic research and her approach to designing and developing web and mobile experiences.


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Prize Recipient
Natalia Guerrero
Massachusetts Institute of Technology
My name is Natalia Guerrero, I'm from Orlando, Florida, and am majoring in physics at MIT. I first considered physics and astronomy as a high school student, stargazing in my backyard. When I got to MIT, I wasn't sure where it was going to take me, but so far, I have found the journey challenging and greatly rewarding and I have fallen in love with the physics world. I am doing research this summer at the MIT Laboratory for Nuclear Science. I am very grateful to the American Physical Society for their support and am looking forward to what the coming year holds.


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INDIANAPOLIS—Jimmie Johnson was the big winner at the Brickyard but here are some other winners and losers from the 20th race of the 2012 Sprint Cup season.
Johnson—He didn't just win, he crushed the field. By leading 99 laps and holding off runner-up Kyle Busch by almost five seconds, Johnson showed that he is as dangerous as ever. More ominous for every other team, Johnson threw down the gauntlet by saying that he wished the Chase would start tomorrow.
Dale Earnhardt Jr.—For the first time in almost eight years, NASCAR's most popular driver sits atop the point standings. His fourth-place finish, combined with Matt Kenseth's crash and 35th-place run, gave Junior a 14-point lead over Kenseth in the standings. Visions of the Sprint Cup will dance through the heads of Junior fans everywhere.
Tony Stewart—The reigning Cup champ was virtually invisible all day but managed to climb into the top 10 by the end of the day. Better still, Stewart showed he hasn't lost his fire when he said in an in-car interview during the race that he would wreck any drivers that blocked him.
Martin Truex Jr.—Truex wasn't ever a threat to win but his eighth-place run gave him his 10th top-10 of the year. If he can keep that up and steal a win in the next six races, he'll be right in the mix for a Chase wild card.
Matt Kenseth—Kenseth's day ended abruptly after Joey Logano spun into Kenseth on lap 134. His 35th-place finish pushed him out of the points lead to second.
Carl Edwards—This was the last thing Edwards needed. In a fight for a wild card, the engine of the No. 99 went bad within the first dozen laps. Worse still, it put Chad Norris, in his debut as crew chief, in the crosshairs as he tried to diagnose and fix the problem.
Regan Smith—After Casey Mears blew a tire on lap 93, Smith and his new crew chief, Todd Berrier, tried to snatch some track position with a fuel-only stop. That catapulted the No. 78 to second on the restart. But Smith couldn't hang on and finished the day 18th.
Denny Hamlin—Hamlin started on the pole and led the first 26 laps. But on a lap-46 restart, he couldn't keep up with the field and fell from second all the way to 15th. He said afterward that he thought the car just couldn't handle a strong push from another car. Whatever the explanation, the slip-up killed the team's shot at a Brickyard win.


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OK, so it could get awkward.
Thanksgiving dinner, that is. After all, it's coming only two weeks after the election.
On one side, the wounds remain tender. Republicans are still deep into their tour of whine country.
On the other side, victorious Democrats are perfecting their "get out the gloat" operation.
Awkward? Heck, it could get ugly.
As you know, turkey and cranberries with the fam can be tense even in the best of times.
A social work professor who taught my wife at Bryn Mawr once wrote a book chapter on why people's ugly sides tend to come out around the holiday table.
Now, this Thanksgiving, you may face the unappetizing prospect of glaring across the green bean casserole at cousin Suzie, who just can't wait to tell you how she voted for Obama.
Or gazing across the mashed potatoes at your nephew Sloane, who you suspect voted for Romney precisely because he said that thing about binders full of women.
Folks, don't let politics spoil the feast. If we lose our sense of humor about this stuff, the republic is doomed.
So, as a service to America, here are 10 topical one-liners you can use on Thanksgiving Day:
1) Wait, don't take the bird out of the oven. Karl Rove insists it isn't done yet.
2) Sure, our team is down 24 points at halftime, but we're counting on that hopey-changey thing clicking in the second half.
3) Nate Silver projects a 93 percent chance that the spinach dip will be gone by the end of the third quarter.
4) There's one guy I know I'm not voting for again: Sgt. Brody. Not after how he snapped that poor guy's neck in the woods.
5) Grandma, the 99 percent agree: This turkey is scrumptious. And 47 percent of us want seconds.
6) Could you please pass me more stuff? After all, I'm a Democrat.
7) I'm "all in" on this eggplant casserole.
8) Please pass the rice. It can't get confirmed by the Senate, so I might as well snarf it.
9) Let's show those guys in D.C. how to compromise. I'll try your rhubarb pie if you try a piece of my fruitcake.
10) If I eat enough turkey, I might be able to sleep until this fiscal cliff thing is over.
The election is definitely over. Be thankful. And have a great and harmonious holiday.
Have your own one-liner that you're planning to trot out on the holiday. Share them below.
Or by email at
, or on the NewsWorks Facebook page.
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text: I made this for my sisters 30th bay. One for each decade. This was my first time doing the flowers, piping and brushed embroidery. The black cake is chocolate ganache and the other two are carrot cake with cream cheese frosting, which I regret as I struggled to get the fondant smooth over this frosting.


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The New Adventures of Zorro: Zorro rides again on his brilliant black stallion Tempest in this exciting cartoon with Henry Darrow as the voice of Don Diego/Zorro. The villain is Capitan Ramon, the commander of the Los Angeles garrison, who uses his control to gain favor in the sight of the governor. Zorro and his servant/friend, Miguel, don masks to battle Ramon and his oppressive rule.
|September 12, 1981
|Christine Avila Don Diamond Eric Mason Henry Darrow Ismael East Carlo Julio Medina
The New Adventures of Zorro (1981) > Season 1 > Episode 29
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patricireland : amazing episode
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Legend Hye : Glad to see the links have been fixed. Now for this movie.. Thought it was OK, but not as good as the others. This was a


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Awards and Badges
Earn awards by posting, commenting, and reacting!
These awards are for special buzz events that you took part in. They're pretty rare and hard to get!
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text:
A variety of in-line surface treatment technologies are available to promote adhesion in thermoset and thermoplastic composites....
On very hot days, a person who arrives at work after a long commute longs for the coolness and comfort of an air-conditioned office. To ensure this scenario, however, the air conditioning system must be reliable.
Ultrasonic welding can handle most plastics assembly applications. Other friction-based processes, such as vibration welding and spin welding, can usually tackle the rest. However, that necessitates investing in three separate machines at considerable cost....
NAGOYA, JapanJapanese appliance manufacturer Rinnai will start producing gas-powered tankless water heaters in the United States. The company will initially lease a plant in Georgia and later build its own assembly plant there. Investment will total some $79 million....
Manufacturers of complex products, such as engines and transmissions, have long been using radio frequency identification (RFID) technology to error-proof their processes, document quality, and deal with high-mix production.
One of the tricky parts of assembling an audio speaker is bonding the cone and surround—the parts that produce sound—to a metal frame.
Item description: This Appliances Air Conditioners product is by Friedrich - This multi-zone wall-mounted Ductless Split System is a great investment in comfortable room temperature With both heating and cooling capabilities this system can be used all year round The DiamonGold Advanced Corrosion Protection ensures longevity ...... Learn More
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Website design by Business Edge


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CBC SportsRon Artest has told Ken Berger of CBSSports.com that he will sign with the Los Angeles Lakers.
"I'm definitely going to L.A. -- to sign, yeah," Artest said in a phone interview. "Lakers, Lakers, Lakers. I'm in L.A. right now."
Artest said he met with Lakers owner Dr. Jerry Buss Thursday and previously had spoken with Lakers coach Phil Jackson. He was en route to his financial manager's office, where he planned to huddle on the phone with his agent, David Bauman, to finalize details.
The parameters of the deal still need to be agreed upon, however.
"I don't really care about the money," Artest said. "I'll play there for nothing. ... L.A. was very interested in me, and they got me."
By Ken Berger


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Sneak peek inside...
Sideshow announces that the Wolf Predator from AvP:R will be receiving a Legendary Scale Figure. Expect a full reveal early next week with pre-orders beginning March 29th.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, RedfordFilms.com, PastGenerationToys.com, BriansToys.com, ToyWiz.com, SmallJoes.com, MonkeyDepot.com, and Urban-Collector.com.


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Taylor Swift Wins 2012 American Music Award for Favorite Female Country Artist
Taylor Swift made it five wins in a row in the Favorite Female Country Artist category at the American Music Awards when she captured the 2012 trophy tonight (Nov. 18) in Los Angeles.
"Taylor, have you ever won an award before?," presenter Eric Stonestreet of 'Modern Family' asked sarcastically as T. Swift took the stage. She expressed her love for her dedicated fans, more than 1 million of whom picked up her new album 'Red.'
"You guys are the ones who voted on this, and you have made this such an amazing couple of weeks for me with 'Red' coming out," she said. "We just put some of the dates on sale for the tour and you guys sold them out in minutes, and I'm so stoked. I guess what I'm trying to say is, I'm really, really happy right now and that's all because of you. Thank you for voting for this award. I love you guys."
Swift beat out Miranda Lambert and former winner Carrie Underwood to take home the trophy. That makes 11 career American Music Awards for Taylor, and she's still only 22 years old! At this rate, don't be surprised if she's picking up the Lifetime Achievement Award before she turns 30.
Watch the Taylor Swift 'We Are Never Ever Getting Back Together' Video
Subscribe to Lite 98.7 on


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/ Aileifroide Bouldering Guidebook
Our Winter Bouldering League (WBL) and Elevate competitions are back. This is going down in all locations Manchester, Reading,... Read more
The fifth round of the IFSC Lead World Cup took place at EICA Ratho near Edinburgh this weekend. For the first time in 14 years,... Read more
Occupying a menacing position high above the Chew Valley's reservoir, is a grit stone monster of truly biblical proportions. By... Read more
Red Chili rock shoes are making a comeback in the UK this season. For over 20 years founders Stefan Glowacz and Uwe... Read more


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POLICE today appealed for witnesses after three men fled the scene of a burglary in Bishop's Waltham.
The gang are thought to have committed four raids on the same day in the Meon Valley last week.
The incident occurred between midday and 2.55pm on Thursday, June 19 at a house on Dundridge Lane.
A silver Ford Focus was spotted parked nearby and three men were seen to flee empty handed and drive away.
They are described as white men. The driver was five feet eight-nine inches tall and of average build. He had short dark hair and was aged between 20-30. He was wearing a light-coloured jacket and had a local accent.
On the same day three other burglaries occurred in the area. These are being linked.
Between 8.45am and 5pm a house on Curdridge Lane, Waltham Chase, was targeted.
Two watches were stolen, an Oris Diverdate with a black face and a Tissot with a blue face and blue leather strap.
Entry was also forced into homes on Webbs Green and Long Road in Soberton. Jewellery was stolen from one and nothing from the other.
Det Sgt Marcus Baker, from Winchester police station, said: "We are treating these four offences as linked due to the proximity of the addresses."
Anyone with information should contact DS Baker at Winchester police station by calling 101. Alternatively contact Crimestoppers anonymously on 0800 555 111.


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Posted 7 years ago
(304 items)
I got this guy today at my favorite consignment shop. When I was looking around this thing scared me. So I bought him! I swear it watches you, had to take it out of my living room and moved him into the bar. Happy hunting!


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ORLANDO, Fla. - A former employee of the Orange Regional Juvenile Detention Center is nearing trial on a misdemeanor battery charge nearly two years after video shows her lifting a 16-year-old detainee off a chair and tossing her to the floor.
Tia Miller, 31, was not charged until more than a year after the August 2011 incident — and only after the victim's mother, fearing the Department of Juvenile Justice was covering up the criminal nature of the incident, sought help from Gov. Rick Scott.
When she tried to get a DJJ supervisor to report the incident involving her daughter as a crime, Laura Segal said, "He said, 'Ma'am, ha ha. The police don't come out this way.'"
Miller resigned soon after the Aug. 6, 2011 incident was reported to DJJ, but no criminal charge was brought until Aug. 22, 2012.
Her attorney, David Novack, said Miller is preparing for a trial and fighting the charge because, in part, a conviction could prevent her achieving her goal of working with students in the future.
Lindsey Jarmakowicz, now 18, told Local 6 she disobeyed Miller's order to return to her cell because – unlike all other detainees present -- she had not been allowed to use the phone.
"My mom knows it's phone call night. I'm in juvenile detention. Obviously, my mom is going to worry about me regardless," Jarmakowicz said.
After approaching Jarmakowicz and gesturing to her to get out of her seat, Miller is seen grabbing the girl by her jumpsuit, lifting he rout of the chair, and throwing her to the tile floor.
"Honestly, I don't think I did anything to deserve it," Jarmakowicz said. "I didn't lay a hand on her and I didn't touch her."
Miller's attorney said the video speaks for itself, but pointed out this was an especially tense night in the JDC. Rival groups had been feuding and an uprising had just been quelled in the boys' area, he said, so Miller was trying to get the girls back to their dormitory area.
Miller, who lives in Pinellas County, declined to comment.
Jarmakowicz, who had a turbulent adolescence, was being detained at the time after being charged with battery on a law enforcement officer.
"They tried to blame it all on me because I was, you know, in there, a juvenile delinquent, whatever you want to call me, " she said. "But still, regardless of the fact, I don't care who you are ... you don't deserve to be hurt."
Miller has a pretrial status hearing next week, but Novack said he expects the trial will be delayed as he continues to receive and review evidence.
Copyright 2013 by ClickOrlando.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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At the beginning of December, I was contacted by Zoë François, author of Artisan Bread in Five Minutes a Day about doing some promotions for her new book, Healthy Bread in Five Minutes a Day. She was kind enough to send me a copy of her book to experiment with and a signed edition to give away to one of my readers. I was excited to receive a copy, not only because she uses many of our products in her book, but also because I was intrigued by the idea of bread in five minutes a day.
I finally scheduled time for myself to bake this weekend and thought it was a perfect time to play around with Healthy Bread in Five. As usual, the weekend went far too quickly and was packed with activities. I started worrying that I wouldn't be able to get my bread baking started. In a panic last night while dinner was cooking, I picked up the book and started in on my dough… well, it's no exaggeration that you can have dough ready in five minutes! Before dinner was done, I had mixed my ingredients and started the rising process.
It wasn't hard, mix all the ingredients together and put it aside for two hours to rise (AND, it's ok to leave it overnight). Even though I have only heard good things about Zoë's method, I was skeptical. I have baked a lot of bread in my day and I'm used to the routine- proof your yeast, mix dry ingredients, add wet to dry, mix well and knead until elastic. HBin5 has you mix all the ingredients together at once and… NO KNEADING! (I can't say I missed that part at all!) After the dough is mixed, you let it rise until it doubles and begins to fall (about two hours).
When my dough was mixed and in its container, I let it be and went on with my evening. I knew I wouldn't have time to bake bread last night, but with the HBin5 method, you can stick your dough in the fridge and it will keep, ready to use, for up to two weeks. I thought this was the perfect test; tonight, I'll break off a hunk and bake fresh bread for dinner.
I'll let you know how it goes…


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Read reviews about board games for children, for adults and for the whole family. From Scrabble to Scalextric, from Monopoly to Mousetrap board games for all interests and abilities. Compare prices and buy your board games online. You can also add your own opinion about a board game you've played with. - boardgames for all interests and abilities. Comapre prices and buy your board games online.
Brand: Sainsburys / Age: 3 years +
Brand: Vivid Imaginations
Brand: Smyths Toys
Brand: Disney
Brand: Paul Lamond Games / Type: Adults Board Game
Brand: Galt / Age: 3years+
Brand: Ravensburger
* Prices may differ from that shown


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Ranolazine in Ischemic Cardiomyopathy
This study has been completed.
Midwest Cardiovascular Research Foundation
Gilead Sciences
Information provided by (Responsible Party):
Dr. Nicolas Shammas, Midwest Cardiovascular Research Foundation
ClinicalTrials.gov Identifier:
First received: April 28, 2011
Last updated: September 24, 2014
Last verified: September 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Patients with ischemic cardiomyopathy may continue to experience persistent chest pain and shortness of breath despite conventional medical therapy and/or revascularization. The purpose of this study is to determine the efficacy of taking Ranexa versus placebo in patients with ischemic (due to blockages) cardiomyopathy treated with optimal conventional medical therapy and/or percutaneous revascularization.
|Cardiomyopathy Chest Pain Dyspnea
|Drug: Ranexa Drug: Placebo
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
|Official Title:
|Ranolazine in Ischemic Cardiomyopathy Patients With Persistent Chest Pain or Dyspnea Despite Conventional Therapy: A Cross-Over Study
Resource links provided by NLM:
MedlinePlus related topics: Breathing Problems Cardiomyopathy Chest Pain
Drug Information available for: RanolazineU.S. FDA Resources
Further study details as provided by Dr. Nicolas Shammas, Midwest Cardiovascular Research Foundation:
Primary Outcome Measures:
- Combined endpoint of improvement in chest pain symptoms with Ranexa assessed by Standardized Angina Questionnaire or dyspnea using the Rose Dyspnea Scale (RDS)Questionnaire [ Time Frame: 12 weeks ]
|Study Start Date:
|April 2011
|Study Completion Date:
|April 2014
|Primary Completion Date:
|April 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Ranolazine
1000 mg Ranexa orally once daily titrated as tolerated after 1 week up to taking 1000 mg twice daily.
Drug: Ranexa
1000 mg Ranexa orally once daily titrated as tolerated after 1 week up to taking 1000 mg twice daily.
Other Name: Ranolazine
Placebo Comparator: Placebo
1000 mg placebo orally once daily titrated as tolerated after 1 week up to taking 1000 mg twice daily.
Drug: Placebo
1000 mg placebo orally once daily titrated as tolerated after 1 week up to taking 1000 mg twice daily.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Ischemic cardiomyopathy patients on optimal medical treatment. Optimal medical treatment is defined as the continued symptoms of chest pain or dyspnea despite treatment with 2 antiischemic agents (beta blockers, CCB or nitrates). Unless contraindicated, all cardiomyopathy patients should be treated with a beta blocker and an ACEI/ARB.
- Anginal chest pain or dyspnea
- Documentation of non treatable or optimally treated coronary artery disease
- Ejection Fraction of less than or equal to 40%
Exclusion Criteria:
- Less than 18 years of age
- Pregnant or breast feeding
- Patients with non ischemic cardiomyopathy
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01345188
Please refer to this study by its ClinicalTrials.gov identifier: NCT01345188
|United States, Iowa
|Midwest Cardiovascular Research Foundation
|Davenport, Iowa, United States, 52803
Sponsors and Collaborators
Midwest Cardiovascular Research Foundation
Gilead Sciences
|Principal Investigator:
|Nicolas W Shammas, MD
|Midwest Cardiovascular Research Foundation
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Dr. Nicolas Shammas, Principal Investigator, MD, Midwest Cardiovascular Research Foundation
|ClinicalTrials.gov Identifier:
|NCT01345188 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 28, 2011
|Last Updated:
|September 24, 2014
Additional relevant MeSH terms:
Chest Pain
Heart Diseases
Cardiovascular Diseases
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Neurologic Manifestations
Nervous System Diseases
Sodium Channel Blockers
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017


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Monterey bobsledder Nick Cunningham crashed during a training run as he continues to struggle with the four-man sled ahead of this weekend's World Cup races in Winterberg, Germany.
Cunningham's sled rolled over but he and his crew survived the mishap.
"I made a small mistake in curve nine and it cost us," said Cunningham, who is ranked second in the world in two-man.
The former Monterey High football player and sprinter recently switched to the Bo-Dyn "Night Train" four-man sled that teammate Steve Holcomb powered to a gold medal at the Vancouver Games. Cunningham, 29, had driven the sled only three times before the crash.
"I tried to modify to my style it as best I can," he told this newspaper last week. "It just didn't feel right. I'm doing this in a World Cup race. At that point I'm in damage control, trying not to crash, trying not to kill anybody."
Cunningham and crew completed their second practice run without incident.
Holcomb also crashed on curve nine in Winterberg in his new Night Train 2, a sled in which he has won three consecutive World Cup races this season.
"Don't mistake my crash as weakness," Holcomb wrote on his Facebook page. "On the contrary, it shows the commitment, courage, and determination my team has to win. In order to get better and go faster than you ever have before, you must step outside your comfort zone, try things you've never tried, do things you've never done, and see just how far you can push your limits."
Holcomb and his crew also escaped unscathed.
The Americans, who have four World Cup events before the Sochi Games, hope to qualify three teams in two-man and four-man at the Olympics.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Sunday, September 24, 2017
Thyroid Diseases
I`m 17 years old and my weight is 45. My height is 5`4". I am a patient with abnormal thyroxine hormone. Since last Novemver I am taking 75 levothyroxine sodiams daily. Though at first after taking medicine my thyroxine level was normal but now in spite of continuing my medicines, I`m suffering my previous female diseases(irregular periods). Now what can I do?
A lot of different problems can cause irregular periods. You need a blood test called a "TSH" or "Thyroid Stimulating Hormone" level. If that is normal then you and your doctor should look for a different reason for your irregular periods. If your TSH is abnormal then your thyroid hormone dose needs to be adjusted. Note: I am assuming that your weight of 45 pounds is a typographical error.
Thomas A Murphy, MD, FACP, FACE
Associate Professor of Medicine
School of Medicine
Case Western Reserve University


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Thank you, Mr. Fukui. We're going to Clean, Safe and Fun in just a minute,...but first, I'd like to tell you a little bit about the year we just finished. 2005 was truly remarkable for Honda. It began with the launch of the innovative Ridgeline truck, and continued with significant updates to the class-leading Accord and Pilot SUV, culminating with the debut of the radically transformed 2006 Civic.
Along the way, we recorded our 10th straight year of record sales, earned a number of awards and achieved some industry firsts. Most notably, Motor Trend Magazine chose Honda products for both car and truck of the year, the first time that any manufacturer has received both awards in the same year.
Motor Trend named the Ridgeline 'Truck of the Year' - an extraordinary achievement for a pickup in its rookie year, - and validation of Honda's unique approach to the pickup segment. Importantly, the Ridgeline continues to gain momentum with consumers as well, posting sales gains in 10 of the past 11 months. Additionally, the all-new 2006 Civic's combination of style, technology and value earned it Motor Trend Car of the Year honors.
As thrilled as we are about these accolades from some of the industry's toughest critics, we're equally proud of our track record on safety and environmental performance, made even stronger by the arrival of the Ridgeline and the new Civic. This year, once again, Honda has the highest corporate average fuel economy rating and the lowest overall emissions of any full line automaker.
And as Mr. Fukui has indicated, we intend to further strengthen this position. And the car we're debuting here today is no exception to the rule. If you don't mind my saying it ... I think it will be a perfect "Fit" in our lineup.
Last year we unveiled the Ridgeline, the largest vehicle in Honda's line up. Today we are here taking the wraps off our smallest vehicle - but make no mistake, there is nothing undersized about this car's safety performance, its innovative features or advanced technology.
It's a highly refined premium entry-level car featuring a number of firsts for the subcompact segment that will immediately make it a class leader. In fact, we believe it will fit perfectly into people's lives...
Already one of Honda's hottest selling cars around the world, the Fit comes to North America with unique powertrain, feature, and safety content to meet the needs of buyers in this market. As the Civic has gradually moved up market, it has left room in our lineup for a new entry-level model. But rest assured, the new Honda Fit delivers a lot more than just typical small car value and fuel efficiency.
When you look at other entries in the subcompact segment, the Fit arrives at the top of the class in terms of standard safety, refinement, interior flexibility, and fun to drive character. The Fit will appeal not only to entry level consumers, but will also appeal more broadly to consumers looking for a fun, flexible and fuel efficient small car that serves as an ultra-comfortable cargo mover.
Powering the Fit is a 109-horspower VTEC engine, and a 5-speed automatic transmission that's unique in this class. The estimated 33 / 38 city and highway mileage is among the best fuel economy ratings for conventional gasoline engines in 2006.
Demonstrating its fun-to-use spirit and Honda's industry-leading packaging ... unique flip and fold magic seats are standard in the Fit. These innovative 60/40 split rear seats allow the seatbacks to dive down into the floor or the seat bottoms to flip up, providing unprecedented seating and cargo carrying flexibility. In a demonstration of impressively big smallness, there's nearly as much passenger volume as an Accord, and only slightly less cargo capacity behind the second row than an Element.
Fit comes with the most standard features in its class making it a leader among subcompacts. For example, we know that our customers want more audio entertainment options, and we'll be the first in the segment to offer a new level of iPod connectivity that will interact fully with the audio system.
The Sport model comes with steering-wheel mounted paddle shifters - not only a first for Honda, it's also a first for the segment. The Sport package adds an underbody kit, rear roofline spoiler, fog lights, aluminum-alloy wheels, and an upgraded audio system.
The Fit is a subcompact that does not compromise on safety. Adhering to Honda's "Safety for Everyone" initiative, Fit has the most standard safety features in its class.
The Fit will go on sale in April as a 2007 model, and we're projecting sales of approximately 33,000 this year and 50,000 on an annual basis. We'll be announcing the price a little closer to launch timing, but we expect the base model will start between 13 and 14 thousand dollars. But the Fit is only half the story for Honda in 2006.
This fall, we'll introduce an all-new, completely re-engineered CR-V. And for the first time, we will be producing the CR-V in North America...at our East Liberty, Ohio, auto plant along side the Civic Sedan and Element...demonstrating once again the value of our flexible manufacturing system.
With the introduction of Fit in April and all-new CR-V this fall, along with continued momentum from the new Civic and other key models, we're projecting Honda Brand sales of around 1.3 million in 2006, which would make it our 11th consecutive record year.
Thank you for your time and attention this afternoon... let's make it a clean, safe and fun year.