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A Randomized, Double-blind, Placebo-controlled, Combined Single Ascending Dose and Multiple Ascending Dose Study
This study has been completed.
Eisai Inc.
Information provided by (Responsible Party):
Eisai Inc.
ClinicalTrials.gov Identifier:
First received: October 27, 2010
Last updated: May 20, 2013
Last verified: February 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study will be to evaluate the safety and tolerability of BAN2401 at sequentially ascending doses in subjects with mild to moderate Alzheimer's disease (AD).
|Alzheimer's Disease
|Drug: Active Comparator: A Drug: Placebo Comparator B Drug: Active Comparator B Drug: Placebo Comparator A
|Phase 1
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Randomized, Double-blind, Placebo-controlled, Combined Single Ascending Dose and Multiple Ascending Dose Study to Assess Safety, Tolerability, Immunogenicity, Pharmacodynamic Response, and Pharmacokinetics of Intravenous Infusions of BAN2401 in Subjects With Mild to Moderate Alzheimer?s Disease
Resource links provided by NLM:
Genetics Home Reference related topics: Alzheimer disease
MedlinePlus related topics: Alzheimer's DiseaseU.S. FDA Resources
Further study details as provided by Eisai Inc.:
Primary Outcome Measures:
- Single Ascending Dose (SAD) [ Time Frame: baseline to Day 180 post-dose ]To evaluate the safety and tolerability of single intravenous (i.v.) infusions of BAN2401 at sequentially ascending doses in subjects with mild to moderate Alzheimer's disease (AD)
- Multiple Ascending Dose(MAD) [ Time Frame: baseline to Day 264 post-dose ]To evaluate the safety and tolerability of 4 monthly i.v. infusions of BAN2401 at sequentially ascending doses in subjects with AD
|Study Start Date:
|August 2010
|Study Completion Date:
|February 2013
|Primary Completion Date:
|October 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Active Comparator: Active Comparator: A
Drug: Active Comparator: A
BAN2401 Single Dose Ascending Single intravenous infusions at sequentially ascending doses on Day 1 (dose levels: 0.1, 0.3, 1, 3, 10, and 15 mg/kg)
|Placebo Comparator: Placebo Comparator A
Drug: Placebo Comparator A
Placebo Matching Placebo Infusion
|Active Comparator: Active Comparator: B
Drug: Active Comparator B
BAN2401 Multiple Dose Ascending Intravenous infusions once every 4 weeks at sequentially ascending doses (dose levels: 0.3, 1, 3, and 10 mg/kg)
|Placebo Comparator: Placebo Comparator B
Drug: Placebo Comparator B
Placebo Matching Placebo Infusion
Detailed Description:
This will be a multicenter, double-blind, randomized, placebo-controlled study in subjects with mild to moderate Alzheimer's disease. The study will comprise separate single dose ascending (SAD) and multiple dose ascending (MAD) parts designed to allow the MAD part to be initiated while the SAD part is ongoing.
|Ages Eligible for Study:
|50 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Clinical diagnosis of probable mild to moderate Alzheimer's disease (AD) by National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association Alzheimer's (NINCDS-ADRDA) criteria.
- A Mini Mental State Examination (MMSE) score of 16 to 28, inclusive, at Screening. Subjects recruited to the first 2 SAD cohorts should have an MMSE of > 22.
- Where symptomatic treatment of Alzheimer's disease (AD) is clinically indicated, subjects must be on stable treatment (e.g., with an anticholinesterase inhibitor [AChEI] and/or memantine) for at least 12 weeks prior to the Screening visit.
- On stable doses of all other prescribed medications for at least 4 weeks prior to the screening visit.
- Any neurological condition that could be contributing to cognitive impairment above and beyond that caused by the subject's Alzheimer's disease (AD).
- Any psychiatric diagnosis or symptoms, e.g hallucinations, major depression, or delusions, that could interfere with assessment of cognition in the subject.
- History of transient ischemic attack (TIA), stroke, or seizures within 12 months of Screening.
- Evidence of infection, tumor, stroke or other clinically significant lesions that could indicate a dementia diagnosis other than AD on brain magnetic resonance imaging (MRI) at Screening.
- Other significant pathological findings on brain MRI at Screening, including but not limited to: more than 3 micro-hemorrhages, single macro-hemorrhage; evidence of vasogenic edema; evidence of cerebral contusion, encephalomalacia, aneurysms, vascular malformations or space occupying lesions.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01230853
Please refer to this study by its ClinicalTrials.gov identifier: NCT01230853
|United States, California
|Garden Grove, California, United States
|San Francisco, California, United States
|United States, Florida
|Orlando, Florida, United States
|United States, Georgia
|Atlanta, Georgia, United States
|United States, Indiana
|Indianapolis, Indiana, United States
|United States, New Jersey
|Eatontown, New Jersey, United States
|Princeton, New Jersey, United States
|United States, Utah
|Salt Lake City, UT, Utah, United States
Sponsors and Collaborators
Eisai Inc.
|Study Director:
|Eisai Medical Services
|Eisai Limited
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Eisai Inc.
|ClinicalTrials.gov Identifier:
|NCT01230853 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 27, 2010
|Last Updated:
|May 20, 2013
Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
ClinicalTrials.gov processed this record on September 21, 2017


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COUNCIL homes across the borough are to be revamped as part of a £15million refurbishment programme.
Dudley Council has awarded a multi-million pound contract to community regeneration specialists, Keepmoat, and house builder and refurbishment specialist, Lovell, to upgrade void and occupied council properties.
Thousands of homes will be rewired and given kitchen and bathroom makeovers over the next three years; roofing works will also be carried out and central heating installed – to ensure properties meet national standards and suit tenants' needs.
Housing bosses say the refurbishment programme, which will be in addition to works carried out by the council's own housing repairs team, will help to cut response times for necessary work during busy periods.
Councillor Gaye Partridge, Dudley's cabinet member for housing, said: "I am delighted we have been able to secure a contract which will improve local council housing. For a long time now the housing repairs team has worked with contractors to deliver improvements for council tenants, and it is good to know we have a proven way of working that reduces waiting times for customers, and makes the overall service more effective."
David Gough, regional director at Lovell which has completed numerous Dudley Council projects over the years, said: "This is a major contract win for Lovell and we're very pleased to be able to continue working with Dudley Council."
Neil Baxter, regional director for Keepmoat, said: "We're looking forward to bolstering our team in Dudley with some new faces; at Keepmoat we've always prided ourselves on our continued commitment to training and apprenticeships. Over the next three years we'll be recruiting six apprentices as well as a graduate, and work experience opportunities for local people to help us to deliver this contract."

subset: commoncrawl


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Among the many crimes the Maloof brothers have committed against the NBA, the city of Sacramento and its fans lately, is its theft on Friday of one of the NBA's happier off-the-court moments.
The wreckage of the deal that was supposed to keep the Kings from leaving town, which became public Friday, blotted out all the sunshine created by the sale of the New Orleans Hornets, taking that franchise out of league receivership after 16 contentious and controversy-drenched months.
The Hornets were free. Tom Benson, owner of the Saints, became the city's hero once again. George Shinn, the crook who brought the Hornets there from Charlotte then dumped them in the league's lap, was pushed further into the fans' repressed memories. The NBA commissioner no longer will be able to veto the team's deals. New Orleans' basketball faithful could exhale.
And then, along came another bunch of crooks, the Maloofs, to ruin everything.
The Maloof brothers, Joe and Gavin, used to be the league's ray of sunshine, its breath of fresh air, pumping life and a new attitude into a sleepy town and its only pro franchise. Amazing, isn't it, that just a decade ago, Sacramento was just … this … close to being the center of the NBA universe, with the Kings up 3-2 on the Shaq-Kobe-Phil Lakers in the Western Conference finals, one win away from a certain walkover to an NBA championship that likely would have registered about an 8.0 on the sports Richter scale.
The Maloofs created that. It peaked in June 2002. Now, they are bringing it crashing down, by their own greed, dishonesty, double-talk and double-crossing.
It got out on Friday, while the NBA and Benson were sealing the deal on the Hornets, that the Maloofs were reneging on the handshake deal for a new Sacramento arena, agreed to after marathon negotiations in Orlando in late February that went on right through the start of the All-Star Game. Gavin Maloof even came out of that meeting in tears of joy and emotion.
The city—including mayor and former NBA All-Star Kevin Johnson—and the NBA thought things were on track. The Maloofs said Friday that they are not. Worse, they suggested that the better plan would be to just fix up their current arena—the one that they have insisted for years is so inadequate that it either has to be replaced or the team be moved.
This was the doomsday pronouncement from Johnson late Friday after an emergency meeting with the team owners, according to the Sacramento Bee:
"I wish I had better news. (The Maloofs) are now saying they don't want to do the deal, which essentially means they don't want to be in Sacramento."
Technically, that's not news. The Maloofs have been idling in the city's driveway for years, waiting for a reason to floor it somewhere—such as Anaheim, where they tried to move a year ago before everybody dropped what they were doing to get them to stay.
There is little room to crush David Stern on this one. His coziness with his owners/bosses is well-documented (as former Seattle SuperSonics fans would like to forget), but on this he had fought hard to keep the Kings in the town that by any measure has treated them … well, like Kings.
"I think that there's nothing further to be done,'' he said Friday, adding that realistically, as of now, nobody can commit to the Kings being in town beyond next season.
Nor is Johnson the villain. He's treading dangerous political waters in the capital of the state in the middle of a catastrophic budget crisis, which doesn't really need to be throwing public money at a couple of rich speculators looking for a handout. Johnson is sticking his, and others', necks out. Stern is sticking his out.
The Maloofs appear not to give a damn. By the strictest definition, it's their team, and as most selfish people in their position do, they figure they can do whatever they want with it.
They mismanaged themselves right out of control of their own pet Vegas hotel project, the Palms, wasted all the goodwill of the Kings' successful years, and are now the mortal enemies of the very fans that embraced them in the glory days.
"Sacramento deserves a partner who will honor their commitment,'' Johnson said. "Sacramento deserves a partner who wants to work in good faith, and I think that Sacramento deserves better than we've got to this point.''
This time, the NBA deserves better, too. In fact, Tom Benson, part of the league family less than 24 hours, deserves a better partner.
At least he deserved a day of good news all to himself.


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Group Booking Terms and Conditions
Because you are making a Group Booking, there are additional Terms and Conditions that apply. Please read them and click 'I Accept' below to continue with your booking
General Group Booking Terms
By making a group reservation through Hostelworld.com you agree to the following terms and conditions as set by Hostelworld.com and as set by the hostel in question.
- In order to make a group reservation on Hostelworld.com it is necessary to pay a deposit. The balance is due directly to the hostel according to their payment conditions.
- The booking deposit is non-refundable.
- Please note that any cancellations must be notified directly to the hostel at least 24 hours in advance of your scheduled arrival date, unless otherwise stated in the hostel's conditions.
- Hostelworld.com are not responsible for changes or amendments to your reservation once it has been processed. All correspondence with regard to changes to your booking need to be dealt with directly with the hostel.
- Cancellations for reservations must be made directly with the hostel and must conform with the individual hostels cancellation policy (see below)
- It is your responsibility to pay the balance of your accommodation cost to the hostel in accordance with their payment conditions (see below). Failure to do so may result in your reservation being cancelled by the hostel.
- Individual hostels may have special booking conditions relating to group stays, please read the hostel booking conditions carefully before making your reservation.
Hostel Specific Terms & Conditions
The remainder of the amount due will be charged to your credit card 1 week prior to arrival. Should numbers or room selection change, the per person deposit times the number of people who actually travelled will be deducted from the total accommodation charge levvied by the hostel.
Cancellation / No Show & Reduction in Numbers Policy
If you wish to cancel a confirmed booking, such notice of cancellation must be communicated to us in writing in all instances. We will attempt to re-sell the accommodation that has been cancelled, but if we are unable to do so without incurring loss, a cancellation charge will be made to you according to the scale. In the event of cancellation by the hirer, the following cancellation charges will apply:
Fourteen or more days' notice prior to date of arrival: Full Refund,
Three to thirteen days' notice prior to date of arrival: A £10 administration fee will be deducted and the remainder will be refunded.
Three days and less notice prior to date of arrival: Full amount will be forfeited.
The following group types are not accepted by this hostel: Junior / Primary School, High / Secondary School If you have misrepresented the type of group you are booking for, your booking may be cancelled by the hostel.
Any cancellations resulting from agreement to these terms and conditions under false pretences will result in loss of deposit.
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12 Foods All Nutritionists Eat
Makeup Counter Testers
It might be imperative to selecting the right shade, but avoiding makeup counter testers could have a significant impact on the amount of germs you pick up this winter season. An undercover test conducted by "Good Morning America" found that one out of every five samples tested from 10 stores across two states showed significant growth of mold, yeast or fecal matter. Better to be safe than sorry: buy and try the makeup at home or try and limit the number of items you test in the store.
Soap Dispensers
It seems odd, but studies have shown that even soap can harbor bacteria, and dispensers are no better. After being touched constantly with dirty hands, the dispenser is a feeding frenzy for bacteria and other germs, not to mention that the containers are not regularly cleaned. Give those germs little chance to make you sick by following good hand washing protocol: scrub hands, nails and wrists with plenty of hot water and soap for 15 to 20 seconds.
Your Guide to Getting a Beach-Ready Body


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Board Appreciation & Installation Reception
The Coral Gables Community Foundation's annual installation of officers and directors was held recently at Seasons 52.
Carlos F. Garcia, CPA, began his two-year term as chair with a board retreat prior to the installation at which directors discussed community and foundation initiatives.
Attorney William A. Bonn completed his term as chair and continues on the board as immediate past chair; as such, he plans to help lead the foundation's development efforts.
Coral Gables Mayor Jim Cason did the honors of swearing in first the executive committee and then the full board at the reception, which was held Monday evening, Jan. 28.
Executive Director Andria Hanley thanked Mr. Bonn for his two years of service and presented him with a framed photo collage representing his years of wonderful leadership.
Serving with Mr. Garcia and Mr. Bonn as executive officers are Chair-elect Tony Rogers, JD; Secretary Jerry Santeiro, Treasurer David Olazabal and Asst. Secretary/Treasurer Karelia Carbonell.
Members of the board of directors are John Allen; Marc Berenfeld, CPA; Pat Blanco, BSN, MPH, FACHE; Amanda Bonifay, CPA; Catherine Grieve, Esq.; Andy Gomez, Ph.D.; Zeke Guilford, Esq.; Michael Harris; Vicente Lago; Matthew Meehan; Jason Neal; Lee Osiason, Esq.; Frank Quesada, Esq.; Aura Reinhardt; Mark Trowbridge and Marielena Villamil.
Guests included University of Miami Director of Advancement Sergio Gonzalez, City Commissioner Ralph Cabrera and past foundation Chair Jeannett Slesnick.
Seasons 52, 321 Miracle Mile, kindly provided the venue and delicious flat-bread pizzas.
Founded by community leaders in 1991, the Coral Gables Community Foundation fosters programs and initiatives that enhance the quality of life for people living and working in the "City Beautiful."
Photos by Betty Alavarez / Events Photographer


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Geography, ethnicity, income and other factors influence retail produce trends across the Southwestern U.S., just as they do throughout the rest of the country.
Phoenix, however, is different from some other Southwestern cities because it often serves as a test market for retail trade and other industries.
"There's just about every (retail) concept you can imagine here (in Phoenix)," said Greg Reinauer, senior vice president of Amerifresh Inc., Scottsdale, Ariz.
Reinauer said Phoenix has an array of retailers that focus on diverse concepts, including the Hispanic or Latino market (Bashas' Food City; Pro's Ranch Markets), the smaller bulk food store (Sprouts Farmers Market), the fresh and natural market (Whole Foods Market), and the neighborhood store (Fresh & Easy Neighborhood Market). There are several Wal-Mart Stores concepts — Sam's Club, Neighborhood Market and Supermercado de Walmart — in the area, as well as gourmet markets, such as Bashas' A.J.'s Fine Foods.
Any of those retailers might choose to feature local produce in their stores.
"Wanting local produce is very, very big," said Barry Zwillinger, partner in Legend Distributing LLC, Glendale, Ariz.
"We're aggressively working to lead that … in some of the items that we're looking to get into growing on our local farms."
Some retailers are aggressively looking for locally grown produce, and Legend is working with its retailer customers to feature more local items.
"I expect in two years it will be a big part of our business and the fresh produce business in Arizona," Zwillinger said.
He said he knew of a couple of retailers who have space dedicated to local products. He declined to name the retailers, but said one has about 15% of the space throughout its store committed to local products, including produce. Consumers in Arizona can find local vegetables during the winter, but that's not the case in El Paso, Texas.
El Paso consumers don't have much interest in locally grown produce because it isn't a crop-producing area.
"It's basically desert," said Nick Delgado, owner of Quality Fruit & Vegetable Co. in El Paso.
New Mexico, however, grows lettuce, chilies and onions, and consumers there do support local growers, Delgado said.
"Especially the way the economy is today," he said.
Marketing local produce is a newer strategy in the Southwest, said Willie Itule, owner of Willie Itule Produce Inc., Phoenix.
Itule said he thinks locally grown produce is more popular now because it can be more affordable and because retailers are using local as part of their marketing strategy.
"When the economy turned down, retailers backed off organics and went to local," Itule said.
New Mexico has a good market for organic produce, but El Paso has only a small organic presence, Delgado said.
"A couple of stores do well with it, but in small amounts in comparison to what I've seen in Albuquerque," he said. "They're probably more price-conscious in El Paso."
Organic produce is important for some retailers in the Southwest, but Legend doesn't feature organic items, Zwillinger said. It occasionally handles some organic produce, but it doesn't fit the company's current strategy.
Reinauer said organic produce seems to be a steady segment in the Southwest, but it is not a growth category for Amerifresh. It represents only a small part of its sales.
In Arizona, retailers use specialty produce to stand out from the competition, Itule said. The trend is most visible in high-end supermarkets, but midlevel supermarkets also are beginning to handle small quantities of specialties as a way to hang on to customers, he said.
"Every retail produce department is out there looking for the specialty product that is going to make them stand out from the other stores," Itule said. "The more unique the item, the more desirable it is for them."
Although most of Itule Produce's business is with foodservice and restaurant buyers, its strong point with retailer buyers is in specialties, Itule said. Itule Produce can typically source specialty produce within 24 hours. In December, for example, Itule could source a variety of specialty radishes, baby carrots, baby kohlrabi and all colors of baby beets within a day.
The growth in specialty produce has been occurring for the past two to three years in Arizona, Itule said. He said he thinks consumers have been cooking more often instead of going out, and they look for specialty produce to make meals at home more special.
El Paso is not a strong market for specialties, Delgado said. Instead, produce that appeals to the Hispanic market is very popular.
The Hispanic market is important in the Phoenix metropolitan area, too. Supermarkets designed to appeal to Hispanics are a growth segment, Zwillinger said. The potential for this market has grown considerably during the past three to four years, and Legend's sales to mercados are a growing part of its business.
Historically, ethnic-driven markets have been important in the Southwest, Reinauer said. As the Hispanic population grows, more retailers are responding to demand and entering the market.
"That Hispanic demographic has a tendency to have a higher produce consumption rate than Caucasian consumers," Reinauer said. "I think some smaller retail markets have always realized that, but now we're seeing larger players starting to understand that."
In June 2009, Wal-Mart Stores Inc. remodeled a Neighborhood Market in Phoenix and opened it as the chain's second Supermercado de Walmart. The first Supermarcado opened in Houston earlier that year.
Bashas' Food City Supermarkets is an Arizona chain that targets the same market. It features on its website the prickly pear cactus as a popular vegetable. The Phoenix Food City's Dec. 15 weekly ad circular featured cilantro bunches priced at six for 96 cents, 3 pounds of limes for 99 cents, banana leaves for 99 cents a pound, green chilies at 3 pounds for 99 cents, and jicama priced at 4 pounds for $1.
The Kroger Co. opened its first Fry's Mercado in 2006 in the Phoenix area, according to The Arizona Republic. Pro's Ranch Markets, a California-based supermarket with what it calls a "Hispanic store concept," opened in Phoenix in 2002, and has added stores to the area in six of the last eight years, according to its website.
As in many other North American markets, produce suppliers in the Southwest are now targeting marketing directly at consumers, said Jose Felix, partner in Delightful Quality Produce Co., Mesa, Ariz. Felix said his company uses several techniques to draw consumers' interest and to familiarize them with Delightful's products and labels.
Its main strategy is working with Beau MacMillan, chef at Elements restaurant at Sanctuary on Camelback Mountain resort and spa, Paradise Valley, Ariz., to provide exclusive recipes to consumers through "Beau Mac's Delightful Secrets" program. Delightful's labels for its tomatoes are double sided, with a MacMillan-created recipe on the back of each. The recipe is created specifically for the type of tomato that the label is on.
"We're trying to differentiate ourselves and the types of tomatoes that we're selling," Felix said.
Recipes are changed to reflect seasons or holidays, Felix said. He said he expects recipes to be available in the next few months on Delightful's website, http://delightfulquality.com.
Delightful has a one-year contract with MacMillan to provide recipes. The contract started in about August, Felix said. The contract doesn't specify the number of recipes to be provided.
Another direct-to-consumer strategy Delightful uses is an appeal to safety concerns. Each package has a traceability number on it, which can be entered on the company's website to discover when and where the tomatoes were harvested. Felix said the company's traceback program is another point of differentiation.
"Very few (companies) are tracing on a clamshell or mesh pack level," he said.
"Some are tracing on a case basis, but that information is only available to the retailer buyer. We are going to the consumer."


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Artist description:
We enjoy warmth because we have been cold. We appreciate light because we have been in darkness. By the same token, we can experience joy because we have known sadness Art saved me; it got me through my depression and self-loathing back to innocence
Flash Draw Created Jun 28, 2012 460 x 640px Unless noted Copyright 2012 NT1B.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
This is amazing! Love the texture you created for the skin.
great draw! nice attention to detail.
still love this one
I agree with you completely! True statement. And BEAUTIFUL DRAWING!!!!!!!!Faves!
very very beautiful.
brilliant, liked :)
so f***ing amazing
amazing...absolutely amazing.


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I know that you are not allowed to alter discs. What I want to know is how bad is it to cheat with the discs you use in a tourney? How will anybody find out?
Let me give an example. I have a 188 Z comet that I was labeled as a 180. If I didn't get a scale to weigh it, I would never know. I could have been throwing an illegal disc in tourneys and never had a clue.
I also have a disc that I don't use that weighed in at 2 grams over its max legal weight. I was thinking about scuffing it up with sandpaper to "help" it break down during normal use to a legal weight. I also know that this is illegal, but if the disc is a legal weight, and my disc shows no signs of "tampering" I would think I (anybody) would get away with it.
Is one violation worse than the other? Am I just out my $12 because I believed (insert disc company here) could weigh their discs?


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Hybrid Golf Clubs – The Club That Does It All
Buying Tips
Expert Advice
Combine the desirable qualities of irons and fairway woods into one club. Discover how hybrid golf clubs for men can benefit your game.
Decide which clubs you want to replace with easier-to-hit hybrid golf clubs. Loft options include 2H, 3H, 4H and 5H for right and left-handed players.
Choose hybrids and rescue clubs from the top brands in golf, including TaylorMade, Titleist, PING, Callaway, Cleveland, ADAMS GOLF, Cobra, Nike, Nickent, Tour Edge and Wilson.
Buying Tips
Match your hybrid golf clubs to the irons or fairway woods they replace. Generally, this is how hybrids, fairway woods and irons match up:
- Hybrid 2H = 5 Wood = 1 or 2 Iron
- Hybrid 3H = 6 Wood = 2 or 3 Iron
- Hybrid 4H = 7 Wood = 3 or 4 Iron
- Hybrid 5H = 9 Wood = 4 or 5 Iron
Use the above chart as a starting point for experimentation. Hybrids and fairway woods hit the ball higher and with more back spin than the equivalent iron.
Expert Advice
Get hybrids with the same length and loft as the clubs you replace to avoid distance gaps.
Pay attention to whether your hybrid is offset. Slight offset – similar to an iron – can make the club easier to hit.
Get the right flex for your swing speed. Choosing the wrong flex costs you distance. Choose extra or tour stiff if you have a very fast swing speed. Other options include stiff, regular or senior flexes.


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The iKlip from IK Multimedia gives your iPad a place to be in your music studio. It can mount above or below your microphone. Put a teleprompter App on your iPad for lyrics while you sing or place a musical score on the screen. Other ideas for the iPad in view could be a guitar amp, synth or drum machine. It's made in Italy and it will cost you $39.00. Not a bad stocking stuffer.
"…a multi-angle lightweight iPad microphone stand adapter." – ikmultimedia.com
For more info: ikmultimedia.com/iklip


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Mark Lourenzo
Beacon Correspondent
The Eel River Blue Huskies shut out the No. 1 seeded Eureka Green Jacks this past Sunday, in the semifinal round of the Six Rivers Youth Football Conference. The Double AA Huskies have been so hot down the stretch this season that they have allowed just six points, while averaging 35 points themselves in their last four games. Two of those games have come in the Six Rivers AA playoffs where they have blanked both of their opponents in the first two rounds of the postseason. We shall see if they can continue their streak as this Sunday they will face the Del Norte Blue team for the conference title at Humboldt State University, kickoff slated for noon. Their Double AA battle will be the second of three games in the youth football championship series. The Single A division will pit the No. 1 seed Del Norte White versus the No. 3 Eureka Red Loggers at 9:30 a.m. Following the Double AA game, it will be No. 1 seed Del Norte facing No. 2 seed McKinleyville in the Triple AAA Division at 2:30 p.m.
Last Sunday, at Fortuna High School, it was all ERV Huskies Blue from the opening minutes as they played host to No. 1 Eureka, a team they lost to in week five of the regular season. On the Huskies' opening possession and just several plays into the contest, Eel River quarterback J.B. Lewis tore through the Eureka defense on his way to a 48-yard touchdown run. The Huskies missed the PAT attempt but led early 6-0. Eel River did not score on their next possession but did pin the opponents down with an excellent punt that laid to rest at the Eureka 7 yard line. After a defensive stop by the Huskies, it was a short punt that gave Eel River its next scoring opportunity.
Starting at the Eureka 30 yard line, Eel River pushed forward and converted a 4th and goal at the 5 yard line with a quarterback Lewis keeper. Though once again missing on the PAT, matter not as Eel River led 12-0 with just :39 to play in the first quarter. Eureka answered with a solid running game and gained a couple of first downs on the ground, but before midfield the Green was forced to punt again. Just as the Huskies were starting to move into Jacks territory, a fumble gave the ball back to Eureka. However, just five plays into the drive a Eureka pass was intercepted by the Huskies Church Crenshaw and Eel River regained the momentum.
It took seven plays to go 45 yards and once again J.B. Lewis outran the Eureka defense to the end zone, this time a 10 yard keeper around the end. A Eureka drive fizzled to end the first half and Eel River led 18-0. The momentum did not change with the new quarter as just three plays into Eureka's initial possession of the 2nd half, a fumble was recovered by Hunter Turner for the Huskies. Though the Huskies offense did not cash in on that turnover, the defense was keeping the opponents at bay. In fact a desperate Eureka attempt on 4th down led to a Husky sack of the opposing quarterback by Turner and Adam Medeiros. Eel River took over in the Eureka redzone and five plays later, Lewis ran in a one yard keeper to up the advantage.
A QB Lewis pass to tight end Zac Claus gave the Huskies a PAT conversion and the lead was now 25-0 with just 1:51 left in the 3rd period. The quarter ended with another Eureka possession that this time brought them to the Eel River 27 yard line and perhaps a score. However, an incomplete 4th down pass ended that hope. Eel River ended the game with their longest drive, a dozen plays took the Huskies to the goal line and Mason Fields pounded it in from two yards out. The Eel River defense was led up front by Sheaden Sanderson and Brendon Harralson, linebackers Church Crenshaw and Adam Medeiros filled the gaps and defensive backs Travis Lourenzo and Hunter Turner cleaned up from there. Del Norte came to the title game with wins over Del Norte Gold and Southern Humboldt. Both Eel River and Del Norte sport a record of 8-2.


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Hello all.
The venerable Buddharakkhita Bhikkhu, a Ugandan monk, is currently in the end stages of producing a book on Buddhism and the environment. He is not a native English speaker and thus his writings, while very wise, are in need of editing. I have been working with him this last couple months to put it together, and it is almost complete. However, I am headed to a monastery next week and will be without access to a computer. The book may be done, but I want to make sure that, if he adds more material or needs any changes made, there is someone who is able to help with the project while I am gone. It would mostly be formatting a word document and maybe editing or proofreading. Please let me know if you're interested. A background in editing or word processing would be helpful. The Ugandan Buddhist Centre is a great organization and it would be a tremendous act of merit to help Bhante Buddharakkhita put this together.
Here's a short video of the Venerable speaking about the Dhammapada. He is truly a wise teacher!


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Rational DOORS Next Generation can also integrate with third-party products.
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IBM Rational DOORS Next Generation for the current IBM Rational DOORS 9.x user
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IBM® Rational® DOORS® Next Generation is a requirements management tool that you can use to capture, trace, analyze, and manage changes to information. It builds on the Rational DOORS 9 rich client and the Rational Requirements Composer web client.
Rational DOORS Next Generation includes a rich client and a web client. You can use the rich client to quickly create and manage business requirements. In the web client, you can further define, elicit, capture, elaborate, discuss, and review requirements and artifacts.
The rich client is based on IBM Rational DOORS 9, and the web client is based on IBM Rational Requirements Composer.
It runs on the Jazz™ platform. This product is the first step in the process to bring Rational DOORS more fully into the requirements management (RM) space of the Rational solution for Collaborative Lifecycle Management, where it can integrate with Rational tools in other spaces, such as change and configuration management (CCM) and quality management (QM).
Rational DOORS Next Generation can also integrate with third-party products.
Check out the demo! It is all part of creating a smarter planed!
Agile development for real-time: Embedded applications
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In this 6-part demos series, watch and learn about a day in the life of an agile development team. From a requirement to the final test run, watch how the team solves problems using smart software. You'll see demos of Rational Team Concert, Rational DOORS, Rational Rhapsody, and Rational Quality Manager, all working together.
Part 2 shows defining the sprint goal and aligning the test cases
Part 3 shows creating a test plan
Part 4 shows developing an integrating a build
Part 5 shows executing test cases and submitting defects
Part 6 shows rerunning test cases
It's all part of creating software smarter....
Here is the link to the demo series
IBM Rational Doors opens the door to a Smarter Planet
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Now this is a tool to help create a smarter development environment!
IBM® Rational® DOORS® Web Access enables stakeholders across your organization immediate access to the latest project requirements and traceability relationships. Rational DOORS Web Access provides secure, zero-footprint access to the central DOORS repository to enable stakeholders such as business users, developers, QA, marketing, and suppliers to stay up-to-date with the latest project requirements -- across the project and around the world. Take a closer look at how DOORS Web Access provides clear visibility into requirements and traceability relationships using the DOORS desktop client.
Check out the demo!
It is all part of creating a smarter planet through software!
When Systems Connect the World Gets Smarter
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Internet and digital technologies are transforming the way we live and work today. New technologies are transforming how we share information, make relationships and make decisions.
It was just in the 1980's, when message centers still existed and businesses manually collected all telephone messages. We will skip the steps in between, like the answering machine, but now we have VOIP that sends our voicemail directly to our email inbox. We can be anywhere in the world, including at home by the pool and collect our telephone messages instantly, from our laptops or hand held devices.
Our global teams usually communicate through instant messaging. We Collaborate real time with each other for insights, information and answers. Your team member could be in Dublin while you live in Toronto. Instant information from 3000 miles away. You might just as well be in the office next door.
We are in a new era and it has only just begun. It will be software development teams, who will continue to transform and create this Smarter Planet through software. All business processes, hidden knowledge and services will become digital for quick access, to make faster and more effective decision making, Innovation will thrive and lives will be saved. Social software will allow us to find people with areas of expertise outside of our immediate teams, who will also provide us information to make the best decisions and blossom new innovation.
Creating a Smarter Planet isn't going to be exactly easy, but it will be a lot faster and development teams will be a lot smarter and effective if they have the right software development tools. Using development tools that provide communication for global teams, that automate project status and efficiently track progress of the project, will help us build better quality software faster.
Creating a Smarter Planet starts with software development..
IBM Rational DOORS
Top 10 Technical Demos of 2011
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Check out the top 10 technical developerWorks demos of 2011!
Exploiting Rational Team Concert with Rational Rhapsody for complex systems and software development
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Based on the Jazz platform, IBM Rational Team Concert provides a lean collaborative lifecycle management solution with agile and formal planning, project reporting, process workflow, work item management, source code management and build management, in a single integrated product supporting all popular platforms. Combine that with IBM® Rational® DOORS® Change Management integration feature and The IBM® Rational® Rhapsody® model-driven development environment creating real-time or embedded systems and software, then you have a full orchestra.
Check out this demo that provides a short introduction on using IBM®Rational® Team Concert for complex systems and software development. It takes you through a scenario that uses several IBM Rational products to show how process controls can be enacted through rule based process guidance. The demo starts in the Rational DOORS requirements database where integration is used with Rational Team Concert to create an implementation request for some work to be performed in an IBM Rational Rhapsody model. It then steps through a work flow using the features of Rational Team Concert to manage both the changes to the model and a formal review process enacted on the project.
It's all part of creating a smarter planet through software development!
Systems and Software Engineering Accelerator
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There are fundamental tools and solutions that are needed throughout the develpment lifecycle:
Requirements management:
Check out this demo that provides a solution for systems and software engineering.
See a demonstration of IBM's Rational solution for systems and software engineering. Using Rational DOORS, Rational Team Concert, Rational Rhapsody and Rational Quality Manager, you can reduce the time, cost and risk of developing profitable products and systems. Learn what core strengths and capabilities this Rational solution provides.
It's all part of creating a Smarter Planet!
Top 10 Demos for 2010
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Top 10 Demos for 2010
developerWorks demos help you discover what a product has to offer ranging from quick product walkthroughs, from installation and setup, and real-world scenarios. Watch and learn step by step and get tips and techniques before trying it yourself.
Here are the top 10 demos for 2010, that your colleagues have found very interesting.
It is all part of building the skills to create a smarter planet, through software.
Creating a requirement in Rational Requirements Composer and transferring it to RequisitePro for management
2009 Top 10 developerWorks Technical Demos
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If you haven't checked out the dW On Demand Demo page, you might want to. We had a tremendous increase in demo views in 2009. It was an 86% increase compared to demo views in 2008.
Here are the top 10 demos for 2009, that your colleagues have found very interesting. It is all part of building the skills to create a smarter planet, through software.
8. Creating a requirement in Rational Requirements Composer and transferring it to RequisitePro for management


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Afternoon Book Club
Thursday, February 20, 2014 - 1:00pm - 2:00pm ~ Kimberly Public Library
Title: Wonder
The Afternoon Book Club will be reading Wonder by R. J. Palacio. Wonder is the 2014 Fox Cities Reads selection. Read the book and join in community-wide discussions leading up to the author's visit to the Fox Cities, April 9-10, 2014.
Book summary:
Ten-year-old Auggie Pullman, who was born with extreme facial abnormalities and was not expected to survive, goes from being home-schooled to entering fifth grade at a private middle school in Manhattan, which entails enduring the taunting and fear of his clasassmates as he struggles to be seen as just another student.
This book was written for middle school ages, but is enjoyable for all ages and walks of life. Read it together with your family!


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Double-A prospect Williams suspended 50 games
MILWAUKEE -- Double-A Huntsville left-hander Alan Williams drew a 50-game suspension without pay Tuesday after a second positive test for a drug of abuse.
The Office of the Commissioner of Baseball made the announcement on Monday afternoon. Per terms of the Minor League Drug Prevention and Treatment Program, it did not name the substance in question. Testing in the Minor Leagues is more far-reaching than in the Majors, and included penalties for marijuana.
Williams, 23, was signed out of the independent Frontier League in May 2011. He was 0-2 with a 3.00 ERA in three starts and 10 relief appearances at Huntsville.
Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. Kevin Massoth is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Flags of the world: Germany
Flags of the world are often taught to our children in middle primary school. They learn briefly about the history of the country and what the flag and its colours represent. Learn a little bit about Germany and its flag with this colouring printable flag for kids.
What you need:
- computer with internet access
- printer
- paper
- coloured pencils or markers
German flag
Became official: 1949
Description: Germany has had many ups and downs and as a result, although this flag was designed way back in 1832 and used during the revolution in 1848, it only became official in 1949.
The colours of the flag and their symbolism are described below:
"Out of the blackness of servitude, through bloody battles, to the golden light of freedom."
The blackness of servitude is represented by the black at the top horizontal band, red idepicts the bloody battles and the gold represents the golden light of freedom.
Print off your own German flag to colour in. See the colours you need to use below.
Find more paper craft ideas:
- Easy origami for kids
- Video tutorials on how to make paper planes
- Make your own Christmas cards
- 5 adorable Mother's Day cards to make
- 5 fun things to print and make
- 5 ways to display kids' art
Find more printables and fun:
- Chore and reward charts
- Colouring pages
- Easy mazes
- Medium level mazes
- Hard level mazes
- Medium dot-to-dots
- Hard dot-to-dots
- Colour by numbers


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4 Ways To Use Twitter Lists for Business
Did you notice that Twitter added list functionality to follow this week? I have had a few people ask me what is the purpose? So with that; here is 4 ways to use Twitter lists:
- Niche Follow- Simply put lists allow you to follow groups of people based on their niche focus. As Social Media becomes more prevalent in the business word, the ability to focus your tweets on verticals will become more necessary. That reason necessitates the need for Social Analytics. The lists are another way to organize and focus.
- Topic RSS- In a way the lists are almost an RSS aggregator of niche topics. Much like http://www.search.twitter.com allows you to pull RSS feeds of #keywords, listing allows you to focus on topics.
- Who to Follow? – This is an easy one. If someone is being put into a lot of lists, then they are Tweeting items of value. Being added to lists is almost like getting a high rating! This will keep people honest. I know I have started looking at how many lists folks are on before following them. I have made simple criteria of 3 lists before following them.
- Business Intelligence, Competitive Intelligence & Industry Pulse- What a great opportunity to pull in all of the industry experts, stakeholders and players into one list and monitor what they are up to. A huge BI opportunity that all businesses should jump on!
Here is the SEO List we made: http://twitter.com/authoritydomain/seo
I am not sure if you know this, but Twitter lists have been available prior to this week. Here is a few to check out:
TLists: http://www.tlists.com/ (thx to @TazmanianTayTay)
TweepML: http://tweepml.org/TweepGen/createnew.aspx
Ultimately, the ability to organize your followers by niche is much needed! If you have other ideas, please share them in the comments.


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'Biggest Loser' to feature Drew Brees, Tim Tebow, and Eric Dickerson for NFL-themed episode -- EXCLUSIVE
by Dan Snierson
Categories: EW Exclusive, Reality TV, Scoop, Television, TV Biz, TV Scoop
Comments 13 Add comment
Image Credit: Trae Patton/NBC; Adam Rose/NBC
Are you ready some football on The Biggest Loser? The Oct. 4 episode of NBCs weight-loss competition series will feature appearances by a handful of NFL players, including New Orleans Saints quarterback Drew Brees, Denver Broncos quarterback Tim Tebow, and Hall of Fame running back Eric Dickerson, EW has learned. Some of the athletes will be seen competing against the contestants in a throwing contest, while others help the pound shedders with their Last Chance Workout before that weeks weigh-in. Its not just some great athlete coming out and saying Hey, look at me! says BL exec producer Todd Lubin. We actually get to their stories and these NFL guys have unbelievable stories. Drew had a major debilitating injury, came back and won a Super Bowl, so his message was, Whatever the adversity is, youve got to fight through it. Lubin also quips: Its a good chance to get the men to watch Biggest Loser alongside their wives.
The show has previously featured such NFL stars as Steve Young, Jerry Rice, Kurt Warner, and Rod Woodson. The season 12 premiere, with new trainers Anna Kournikova and Dolvett Quince, airs Sept. 20.


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I always said that shot against the Kings were a fluke...I take it back. Horry certainly deserves consideration for the Hall of Fame. What an amazing clutch player.
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I always said that shot against the Kings were a fluke...I take it back. Horry certainly deserves consideration for the Hall of Fame. What an amazing clutch player.
that dunk was sick for a guy in his mid 30's.
i am shocked that he only gets paid the vet. min. his 4th quarter performance tonight most likely determined the championship this year. SA does not win this game w/o horry. i think detroit can win one in SA, no way they get two.
Yea.. he is a great clutch player, thats all... but HOF? Not even close! Career 7 ppg, 1 apg, 1 spg, 0.5 bpg, 4 rpg and he is a Forward/Center... sure he has Rings, but he aint got something to back him up with... just my opinion
That dunk made me fall from my seat.
Horry was clutch from the f.t. line too!
im guessing duncan gives him a nice bonus check after tonites performance.....he single handedly bailed duncan out of many nitemares for years to come....duncan is the best player in the world, but the last few minutes of regulation were not some of his most memorable moments...u almost felt sorry for the guy....
Yeah Timmy was about to scar himself for life.
He does all the things that are intangible. Numbers and stats don't always win titles. Horry was helped the Lakers, Rockets, and Spurs to win multiple championship with unbelievable clutch playing.Originally Posted by 3ptmiller
He said in a post game interview he can hit clutch shots because he plays basketball for fun. He said most guys take it too seriously. Meaning they want it so bad they tighten up.
There's two ways you can be clutch. Horry's way, or to really be focused.
Something Duncan wasn't either of tonight.
Which brings up a question . . . I better not post it here or I'll probably derail the thread. I'll start another thread.
Tim Duncan just said on the post-game interview Rob just hangs out in the game and turns it on in big games in the 4th quarter, he just elevates his game because he usually just "hangs out"
I never said it did.Originally Posted by vapacersfan
All I meant by it is that the poster 3ptmiller said Horry doesn't deserve to be in Hall of Fame because of his stats but I say he should because of his continious amazing performances in clutch games.
i was having flashbacks to nick anderson
Nick "Brick" Anderson
One of the greatest choke-jobs in NBA history.
Bricks 2 freethrows, gets fouled and has the chance to redeem himself......and BRICKS 2 more in game 1 of the 95 finals. The Magic controlled that game and let it slip away, never recovered.
and he never recovered....he was a very good basketball player for quite some time...after that he was never ever the same....pretty sad story actually...Originally Posted by PacerFanAdam
Extremely sad, I wouldn't wish that on my worst enemy. Anderson was a good guy. His best friend in Chicago was killed in high school. He was a basketball standout.
The freethrows are bound to still haunt him, as I'm sure the timeout still haunts Cwebb.
Originally Posted by PacerFanAdam
i just read an article about nick just within the last 2 weeks....they did haunt him....and to a certain extent still do....pretty good read....talking about how the orlando magic kinda let him out to dry after that....hed like to be a part of the organization and they havent really taken him in....i think he was the first player drafted by the magic if im not mistaken...if u do a news search on him u probably find it....
I said only that he aint got nothing else to back him up with to be a HOF... the lucky robert horry is only a clutch shooter (notice the "only")... example Reggie was maybe the greatest clutch shooter in NBA History and he had many stuff to back him up with and he aint even a HOF... and u want Horry to be a HOF!?!?Originally Posted by PacerSoul
I know that stats is very disrespectfull, but it actually shows very many things... proofs how good you are... what you have done... what you can do at your best...
Originally Posted by 3ptmiller
Who says Reggie won't be a Hall of Famer? He will be a first ballot HOF'er.
Robert Horry may not be a first ballot Hallof Famer but he deserves to get in. He single handely won the game tonight and hence the Spurs NBA Championship. Without him, Lakers wouldn't have gotten past Kings.
Why is Big Shot Bob lucky? That's what he does and he always turns it on in clutch performances. He is just a clutch player and is a very valuable member for the Spurs. As Duncan said, he just doesn't try until when it really counts. He just "hangs out".
Dont get me wrong, i love Robert Horry... because i love Clutch players.. What is better? Jordan scores 50 pts on you, and you got only 3 pts (the game winning shot)... which is sweeter? Clutch shots brings joy and feelings to people and people think "Damn he is so good!" even tho he could be a bad player...Originally Posted by PacerSoul
What i mean by Lucky is because he is lucky to get to shoot those last second shots and in whatever team he goes to the Coach want HIM to shoot the ball.. even tho he got better players...
And yes Horry had a great game and won the game, but that was his Season High 21 pts and 5-6 3PT.. he didnt shoot that good in Years! This is where the "stats" come in.. First if you look at his stats you will see that he never shot 83% Accuracy from the 3PT Line and he have never averaged 21 pts a game... This means that he was HOT..very HOT this game...
and this is where "Lucky" comes in.. he was Lucky to be HOT that game and he was Lucky that the game was Tied and HE was gona take the shot.. Do you really think he would still be the chosen one to shoot that shot if he wasnt HOT that game? Pure Luck.. understand?
If he wasnt Lucky and was just him average self with his 30% accuracy from 3PT Line... means he would get only 7 pts at tops and from 6 3PT attempts he would hit 2 shots... understand? This means he was LUCKY.. but thats just another word for HOT i guess..
As Tim Duncan says, he turns up his game in clutch situations. He elevates his game to a whole different level. That's just who he is. Robert Horry doesn't care about statistics, he just cares about getting more rings on his fingers. I think he wants one for each finger and possibly his toes too.
Yea i know... but im talking about HOF, what those people look in a player.. if you look at all those players in HOF you will see the greatest players who played the game... Horry is great clutch player, but comon? That would be great tho if he becomes a HOF, then its prooved that you dont need stats to be one of the greatest... i want that to happen!Originally Posted by PacerSoul
Robert Horry is a clutch player but no HOFer.
Also, Nick Anderson was pretty good up until those free throws. He used to give Reggie fits both on offense and defense.
Originally Posted by PacerSoulLOLOriginally Posted by PacerSoul
He has been a big peice to many championship teams. He may not put up big numbers, but he's NEVER had to.
They go to Horry when it counts, because he's exceptionaly well under preassure.
You're correct, he was the first player ever selected by the Magic, in 1989 I believe.
Did he mess up by missing those 4 freethrows? Obviously, yes. But that was just one game. If Orlando was capable of beating Houston in that series, Shaq and Penny would have found a way to lead the team to a couple of victories.


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Last night we had the hottest ticket in town to the exclusive launch party to the House of Vans London in Waterloo. This amazing space is a creative hub for artists, musicians and skaters and some of the biggest names came out in support for this exciting new venue.
The OFFICE HQ gang got to hang with Steve Van Doren, the son of Vans co-founder Paul who was more than happy to show us around and chat about the iconic brand. The legendary Z-Boys Tony Alva and Christian Hosoi were there showing off their skills and enjoying the incredible music acts that performed throughout the night. These included Dinosaur Jr, Tempa T, Roots Manuva and the hip hop giants Public Enemy.
As you walk in, you are greeted by a huge hall full of artwork and creative installations and at the back is the unique Vans lab which will play host to 4 artists at a time to create their work and eventually display in the art hall.
There is a a cosy cinema which will showcase a range docu-films and private screenings, a room with cabinets full of old Vans memorabilia, an 850 capacity music hall and of course the huge subterranean skate park.
Skaters can book a 2 hour skate/BMX session at http://houseofvanslondon.com/ for free and enjoy everything the venue has offer, including the in-house restaurant.
Last night was a true testament to the Vans ethos as the atmosphere was exciting, friendly and chilled and the venue proved itself as a great hub for anyone and everyone.


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Birth & Midwifery in Uganda
Resources for parents and practitioners
Connect with many more midwives and birth enthusiasts from around the world by joining IAM, the International Alliance of Midwives!
Some of the following sites may not be in English; an online translator may be useful.
Birth Situation Room Report
Midwifery Today Country Contact*
*To learn what a Country Contact is or to reach any Midwifery Today Country Contact, click here.
Edwidge Kezaabu and Violet Kengyeya
Edwidge Kezaabu, completed her Masters in Public Health in 2012, with a Post Graduate Certificate in Project Monitoring and Evaluation, BA Community Development, Diplomas in Midwifery and Nursing, as well as a Post Graduate Certificate in Research Methodology. She is involved also in counselling in reproductive health-related issues, community outreach and home-based care programmes that address maternal and child health. Edwidge has been involved with birth as a midwife, as a trainer of trainers, as a clinical instructor, and as a mother. Her goals for international midwifery are to gain knowledge and share experience and contribute to safe birth and reduce maternal mortality and morbidity. She would like to network with other members to share experiences and research findings. Edwidge tells us, "I love my career and would like to save as many women as possible from complications of pregnancy, labour and puerperium."
Violet Kengyeya is a private midwife since the 1970s who is offering free antenatal checkups to needy mothers in Kampala. She also offers deliveries and care of the child after birth and other services. Violet tells us, "Childbirth and midwifery here is doing a little well but with a lot of challanges; that is why we would love to work with you to see that we get some kind of partnership and more training here." She seeks to help educate her community.
- Africa Midwives Research Network (AMRN)
P.O. Box 7051, Kampala, Uganda
Tel: 256 - 41-323301
Building a Birth House in Uganda
The Shanti Uganda Society improves the physical, emotional and spiritual well-being of communities impacted by poverty, HIV/AIDS and war in Uganda. Our programs include organic farming initiatives, income generating initiatives for HIV positive women, teen girls groups, a birthkit project and the creation of safe and empowering birth spaces.
In December 2009, we begin building the Shanti Uganda Birth House and Learning Centre. In partnership with a natural building organization, the birth house is being built with and for the local community using local materials and is designed to honour the needs of women in the community. It will be a safe and empowering place for women to birth supported by midwives that is similar to a home environment. Design includes an outdoor garden compound and plans for an herb garden. We hope to be complete by spring 2010.
There are many, many incredible practices here in Uganda. The women in the surrounding villages gathered to help us with our garden at the birth house and we got into a conversation about local herbs used during birth. They told us that sometimes the dung of hippos is used! They will be helping us to plant these local herbs in our outdoor courtyard.
Had a great time with the women in the community this morning, who all showed up to work on our garden and volunteer their time. Teared up a bit when a 90-year-old woman came with her hoe to help out and walked up and said in her native Lugandan, "Good morning, I'm here to help." She had no teeth, one of her fingers was half gone and she was the shortest wise woman I've ever seen, but she could dig if it meant building a birth house for the women of her village! The support we are getting from the community is incredible.
Want to get involved?—If you are a midwife, doula, prenatal educator, homeopathic practitioner, herbalist or have other skills that you feel may benefit the work we do in Uganda, please contact us. Currently our volunteer midwives work in the labour ward at the local clinic we support. There are roughly 50 births a month at the clinic and it is staffed by local midwives, doctors and has a room for c-sections. While the Shanti Uganda Birth House is being built, we will also be looking for volunteer midwives to help in the planning and training of local midwives in the area. Once built, volunteers can work both at the clinic, which will be our transfer location as well as at our eco-birth house.
Improve maternal and infant health—Make a contribution towards reducing maternal and infant mortality rates in Luwero District, Uganda. Provide much needed supplies at the Shanti Uganda Birth House, help educate midwives and support prenatal education. (www.shantiuganda.org/products/gifts-of-action)
Donate birth and midwifery supplies, prenatal education tools, receiving blankets, onesies, reusable menstrual pads—Mail to: Shanti Uganda Society, 1900 Bowman Ave., Coquitlam, BC V3J 6E3 Canada
— Natalie Angell
Shanti Uganda Society
Acknowledging Maternal Mortality in Uganda
In June 2010, the United Nations Human Rights Council adopted a landmark resolution acknowledging maternal mortality and morbidity as a human rights issue.
Maternal deaths in Uganda are one of the causes of the high number of orphans. There are more than two million orphans here in Uganda. Ugandan law still places restrictions on the ability of foreign citizens to adopt Ugandan children and most of the children involved are found living in very destitute conditions without any family or love. Those who are lucky thrive with the love and care of their new adoptive families. The Tooro Babies Home in Kabarole District, West Uganda, for example, offers orphanage with assistance from local and international donors, but the orphanage is overwhelmed by the number of children that are brought from nearby communities.
Observing birth as a human rights issue and reducing maternal mortality and morbidity should call for more involvement of policymakers and leaders at all levels. Birth and maternal health should be everyone's concern and not the responsibility of hospital staff alone. Male involvement in patriarchal societies like Uganda should not only be encouraged but should be reinforced with laws. For more information about these issues, visit the following Web sites:
— Kezaabu Edwidge
Midwifery Today country contact for Uganda
Birth Control and Male Involvement in Uganda
It has come to everyone's notice that birth control is one of the most sensitive and difficult issues in Uganda. The country has one of the highest population growth rates in Africa, with an average of over six children per woman. The total population of Uganda is estimated at 32 million, and at the current rate of growth could double in a matter of decades.
There is a deeply embedded attitude that having many children is a good thing. It seems pragmatic—children look after you when you are old, and since some children die, you need plenty to ensure a few outlive you. Producing many children is considered essential to one's identity.
The White Ribbon Alliance in Uganda, with support from many members, is working tooth and nail to put the message about safe birth across. If we could pull more men aboard the campaign, it would make a difference.
In Uganda, maternal mortality has fallen from 506 to 425 per 100,000 live births. Although there is an outcry for births to be attended by qualified health workers, some women still prefer traditional midwives who are within easy reach. The challenge is that traditional midwives prefer to use local herbs that are not measurable and are dangerous to the fetus. Though it is believed that local herbs ease pain during labour and make birth faster, complications to both the mother and the baby may not be noticed until it is too late.
We have a lot to achieve and the United Nation's Millennium Development Goals may be left unaccomplished unless we involve male spouses to help prevent unwanted pregnancies and promote safe birth.
— Kezaabu Edwidge


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From funerals to weddings, I'm glad my first week as an advice columnist is covering the range of life-cycle events. I'm expecting questions on naming ceremonies and Bar Mitzvahs any day now. Keep the questions coming, and if you like what you see, send your friends to the site, too.
Dear Miriam,
I recently received an invitation to a wedding in Florida, and at the bottom of the invitation it said "formal attire required." I know what to wear for "black tie required" events, and I know my sweetie can wear his black suit when it says "black tie optional," and I've even figured out what to wear to a party when the evite says "casual chic." But what is "formal attire required?" And, if you'll permit me a second question, don't you agree that whatever "formal attire" is, I should go buy a new dress?
P.S. I'm not sure if it matters, but the wedding is for a Jewish guy marrying a non-Jewish woman in a non-denominational ceremony.
Wedding Wear Conundrum
Dear Wedding,
The last time I went to an event that specified "formal attire," I think it was my high school prom. It's not a classification I'm used to for weddings, but I think that also gives you some leeway to determine what makes you comfortable. I'd recommend a fancy dress, possibly sparkly and possibly floor-length, but neither of those are imperative. You can (almost) never go wrong with a black dress. Whatever you wear has to feel special and should be something you wouldn't wear just on a night on the town. Or, if it is, dress it up with special occasion jewelry. If it were your wedding, would you be happy to see a guest in it? As for your sweetie, either a black suit or tux would both be appropriate.
On the other hand, my husband points out that this is a question you could google and get a very specific answer, even including pictures of "formal attire." Since you chose to write to me instead of doing that, my guess is there's something else going on here. Perhaps it's more difficult than a google search because it's an interfaith wedding, or perhaps because it's in Florida (and who knows what they wear down there?!). It might be because, as my own quick google research indicated, categories of dress and standards of dress code have been consistently relaxing for the past half a century, and more varied standards can sometimes mean too many options. Regardless, I feel confident in saying that as long as you wear something that covers you and is in good condition, there will be other guests there who are dressed more extreme on both the casual and formal ends of the spectrum.
Speaking of being covered, though, while it might not apply for this wedding, in general, for weddings with any sort of religious nature, modesty is another factor to keep in mind. Particularly if the dress is strapless, many women will choose to cover up with a wrap during the ceremony.
Finally, weddings are a great opportunity to buy something new, so if your budget permits, by all means find a new dress for the occasion. That being said, you're not the bride, and that means that a dress you wear to a wedding doesn't have to be retired after one use. If you have something in your closet that might work, you can also use this as excuse to indulge in some formal-attire-appropriate accessories.
Enjoy the festivities, and I'd love to hear how others interpret the dress code!
Be well,


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Here is the Double Nugget gumball/candy machine I found yesterday. Still need to get the locks picked or new key made. The case cleaned up really good with just a little cleaning. Eventually hope to fully restore it with the black and red paint and some good buffing. Wanted to post these pics for what a difference a little elbow grease made on it. Here is the link to the post I made of it yesterday before I did any cleaning.
The last picture shows where it will eventually have a home with my Atlas Master machine. Anyone have info about the date of this particular unit would be appreciated. I found out that Double Nugget first began producing machines in 1897, and saw one picture of one just like mine that was listed as 1920s but am not sure if that is correct.


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daverupa wrote:I shall, indeed, be napping when the change occurs.
Sam Vara wrote:My two year old is having a nappy new year, but he has made a new year's resolution that 2013 will be the year that he gives them up. (Non-British English speakers might have to look this one up - I know it often causes confusion in the USA...)
For all of us, may 2013 bring happiness and freedom. I'm off to take refuges and precepts at the local monastery in a few minutes, and will include you all in my best wishes.
Cittasanto wrote::) I only just noticed the spelling mistake
bodom wrote:Cittasanto wrote::) I only just noticed the spelling mistake
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Welcome to WHA Website
The World Headache Alliance (WHA) was founded to reduce the burden of headache disorders throughout the world, in particular, by sharing information among headache organisations and by increasing the awareness and understanding of headaches as a public health concern with profound social and economic impact.
WHA is a global alliance of almost 40 national headache organizations from nearly 30 countries worldwide. Please check out the Organizations we've created alliances with.
Please read further about the History of WHA, the Mission and Aims, and about the Services our Website Provides to visitors.
Why Focus on Headaches?
Those who have truly suffered from severe headaches know how disabling a headache can truly be. Likely, everyone in the world has suffered a minor to severe headache at least once in their life and can understand how difficult it can be to continue to carry out simple daily tasks, opting to attempt alleviate the pain by sitting quietly in dimly lit areas, taking a short nap, and taking over-the-counter pain medications. For typical headaches that everyone has experienced, the suffering is usually mild and short lived, as doing things like drinking lots of fluids for hydration and taking aspirin, acetaminophen, or ibuprofen are usually all it takes to subdue the pain.
But what about individuals who suffer from more severe headaches?
For individuals who suffer from severe headaches on a regular basis, life can be disabling at times. The unfortunate thing individuals who face severe headaches is that they may not be able to determine the frequency of the severity of the headache. Some individuals may suffer from headaches a few times a year while others may experience headaches multiple times a week, with timing ranging anywhere between thirty minutes to a few days. Most headaches are unpredictable, with the triggers absolutely unknown, causing life to be miserable and insufferable at times. For those who don't suffer from regular and frequent sever headaches, it may be difficult to understand the struggle of living with pain. But for those who suffer from regular pain brought on by severe headaches, it can become disabling during an episode.
What kinds of headaches are there? There are a variety of headaches one can suffer from. Here are a list of various headaches individuals could suffer from:
- Tension Type Headache: This is the most common form of headache that likely everyone has suffered from at one point in their life. It has been referred to, additionally, as a "normal headache" or an "ordinary headache." Most people who experience the tension type headache will feel a pressure buildup in their entire head, although some people may experience the pressure on one side of their head. The headache itself can last anywhere from thirty minutes to a few days. Triggers for this sort of headache include, but isn't limited to, a change in diet, lack of proper hydration, change in environment, or current mental state. Treatment for such headaches can be found in any drug store or pharmacy. However, depending on the frequency of headaches and how often an individual may find that they need to take an over-the-counter medication may lead to future problems, so consult with a doctor before taking too much medication too often.
- Chronic Daily Headache: Chronic daily headaches occur 15 or more days in a month. These sorts of headaches tend to be dull, but are classified by their ever-presence. For some individuals, the headache never goes away, but the severity levels go up and down throughout the day and night. As of yet, there is no official diagnosis but is solely classified by its omnipresence.
- Migraine: Migraines are a disorder, for which suffers experience attacks or episodes anywhere from a few times a year to a couple times a week. Migraines are an inherited disorder and is as common as 1 in 7 adults. Symptoms include a severe headache, nausea, vomiting, light sensitivity, and sound sensitivity. Very rarely do over-the-counter pain medications aid in relieving the pain, so many individuals who suffer from migraines need a stronger prescription pain medication, taken in a dark or dimly lit room in complete silence. The most severe migraines will last a number of days, leaving sufferers feeling physically ill, unable to carry out their daily tasks.
- Cluster Headache: This is the least common form of headache. Sufferers experience an incredibly severe one-sided head pain, typically in or around the eye. What is unusual about this sort of headache is that sufferers will feel these sorts of pains numerous times a day at the same times for a time span from 6 to 12 weeks, although it may vary from case to case. The pain is short lived, about 30 to 60 minutes, and the attacks happen at the same time every day during its onset.
- Hormones and Headaches Although there is no definitive scientific proof that there is a link between hormones and headaches, there is a definite connection that cannot be ignored. Many women feel the onset of headaches during certain cycles and hormonal changes in their bodies. With research, we hope to find a definitive reasoning behind this.
Why Should We Care?
Although some people tend to just dismiss headaches, for many individuals, the severity and frequency can be completely disabling. Headaches are considered to be neurological disorders in some cases and completely disabling in others. With proper research, we can discover the source and triggers of headaches, and hopefully see an end to headaches worldwide!
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How To Stop Caring What Others Think
Want to learn further about efforts to end headaches worldwide? Check out our global campaign, Lifting the Burden, and learn what strides have been made to ending headaches once and for all!
I Suffer From Headaches, What Can I Do?
Most people tend to dismiss their headaches as just a headache, unaware that they may have something a bit more serious. If you find that you're headaches are occurring more frequent or have become more severe, beware of continuing to relieve your symptoms with over-the-counter medications, as taking too much could cause damage to your body or you could develop an immunity to the medication over time. If you find you're experiencing more headaches, you should:
- Consult your doctor: Although it's a good idea to research some possibilities for your symptoms, do not self-diagnose yourself. The more information you can provide for your doctor, the better they'll be able to determine what you're truly suffering from. Many sufferers of headaches keep a Headache Diary to present to their doctors for accuracy. Additionally, keep track of any and all changes that may have occurred in your life recently.
- Drink lots of fluids: Many headaches are the result of dehydration. Make sure you're drinking lots of water as a natural way of relieving your symptoms before going straight for over-the-counter pain medications.
- Use a hot or cold compress on the pain: Hot and cold can really aid in relieving painful symptoms brought on by headaches. Sitting quietly with hot or cold compresses will help alleviate the symptoms brought about from headaches.
News & Articles
There are a lot of new studies and emerging research in regards to headaches. Additionally, various organization and WHA are making great strides in finding an end to headaches all together! Keep up to date on all topics covered in the media in regards to the mission and aims of WHA. Some of the top stories include:
- Drug management of headache disorders
- Managing chronic headaches
- Headache linked to other disorders
- IAPO 3rd Global Patients' Congress
- Greek headache sufferers join WHA


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Topic: ASCO's 2013 Top Five List in Oncology
Not specifically CC related but thought it worthy of posting here anyway.
ASCO's 2013 Top Five List in Oncology -
http://www.asco.org/practice-research/a … t-oncology
cholangiocarcinoma.org :: Cholangiocarcinoma Foundation Discussion Board
a resource for patients, friends, caregivers and loved ones.
You are not logged in. Please login or register.
|La fundación de colangiocarcinoma (CCF) ahora ofrece servicios de traducción en Español.
Por favor publique sus preguntas en Español y un intérprete le va responder.
Join our new Mentoring Program
A new discussion board experience is coming this September!
After 10 years, we're upgrading our discussion board to a new modern system. The new forum will be easier to use, mobile-friendly and loaded with new features! We'll be taking all of the existing posts and users over to the new board, you won't have to do anything. If you have any questions, we've started a thread here to discuss.
Cholangiocarcinoma Foundation Discussion Board → New Developments → ASCO's 2013 Top Five List in Oncology
Not specifically CC related but thought it worthy of posting here anyway.
ASCO's 2013 Top Five List in Oncology -
http://www.asco.org/practice-research/a … t-oncology
Mmm Gavin, interesting Thanx
Gavin...you are one step ahead of me - had it on my list to post tonight and voila....there you go. Thanks much.
Interesting! thanx.
Good one Gavin. I can print it out and use it to explain why we aren't doing specific things for Mark that people it out lives expect to be done....such as why we aren't using specific nausea meds when he is only at a low-moderate risk for nausea and why no PET scans since he has technically had had his first line treatment (surgery).
Glad you didn't get blown away by the storm.
Glad it was of use and interest to you all, and of course, you are all most welcome. Heard today that my application to get gas central heating installed in the flat has been successful! No more freezing during the long winters anymore and I am well chuffed indeed! Got told as well that it's getting installed in the next couple of weeks so now got a mad dash on to get the decorating finished in time for the installers to get to work. Sooo looking forward to getting back to normal with the flat and being able to spend a bit more time on here as well. 2 weeks max I think. Just got the living room to finish and some other small fiddly jobs to do, new lights, sockets, switches throughout and fix the damp in the kitchen ceiling, and one troublesome wall in the bedroom to paper then paint. The end is in sight, I think!!! lol!
Podcast from ASCO on this topic -
The information expressed is not medical advice. The discussion boards are not intended to replace the services of a trained health professional or to be a substitute for the medical advice of physicians or other healthcare providers. Read the full disclaimer.


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Roenicke delivers rare postgame pep talk on Thursday
ST. LOUIS -- Manager Ron Roenicke was the only one who spoke when he called a rare postgame meeting on Thursday after the Brewers lost for the 12th time in 14 games.
"It gets to a time when I feel like it's right," said Roenicke, who reluctantly discussed the gathering on Friday ahead of a key series at Busch Stadium. "Maybe it's something I feel like I need to say. It may not even be going that bad; it may just be something I see that I need to address. I always have a chance to talk to them that first day on the road, but we're going home for a long homestand [so] it may be two and a half weeks or so until I can say something. Sometimes I don't want to let it go that long."
One of those sometimes came late Thursday following a 7-1 loss to the Pirates.
Asked for his view of the meeting's tone, veteran third baseman Aramis Ramirez said, "We know we're better than we've been playing. We've lost 12 out of the 14 games -- we know we're better than that. Even though we're playing some good teams and facing some good pitching, it's not going to get any easier. We've got to get it done. It doesn't matter who we play."
Roenicke's gathering was not completely unprecedented. He said he called "a couple" of postgame meetings last year, and also occasionally addresses big-picture issues during the Brewers' regular pre-series meetings, especially at the start of a road trip.
Sometimes, veteran players will chime in. Not Thursday, according to Ramirez.
"Just the manager," Ramirez said. "He just tried to keep it on the positive side. You never want to get used to losing. You've got to try and turn it around one way or another.
"I'm not a big fan of meetings, and I'm sure Ron isn't, either. But sometimes you've got to let the players know, 'You're better than what you're doing out there.' And we know we're better than that. We proved it last year -- we didn't start the way we wanted but we played good the last two months, but that wasn't enough. That's why you don't want to get so far behind. Cincinnati, Pittsburgh and St. Louis -- they're really good."
In the first 39 games of his third season as Brewers manager, Roenicke has already removed John Axford from the closer's role, demoted fifth starter Mike Fiers (he has since rejoined the team as a reliever) and made significant alterations to his batting order in light of prolonged slumps for second baseman Rickie Weeks and catcher Jonathan Lucroy.
The Brewers have been streaky, to say the least. After beginning the season 2-8, they won nine in a row and 12 of 15, then lost five in a row and 12 of 14 games entering Friday night in St. Louis.
It has been a challenging couple of weeks.
"Yeah, more than a couple weeks," Roenicke said. "It's been tough on everybody this year. We went through one good span, and that's really been it."
Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. This story was not subject to the approval of Major League Baseball or its clubs.


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VAGUE & BABS: "QUEEN OF THE RING" MS HUSTLE vs QB BLACK DIAMOND | MAIN EVENT WTT
Finally. The battle we've all been waiting for! The two year war of words between Ms. hustle and QB Black Diamond gets settled once and for all. This one is definitely going in the books as a classic.


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Do you think people are more apt to repay acts of generosity, or greed? In five experiments involving either money or work conducted by the American Psychological Association, recipients of acts of generosity didn't extend that generosity to others any more often than those who had been treated equally. However, those who were the victims of greed were more likely to react by being greedy with others.
For example, in one experiment, recipients were told that an unknown person had split $6 with them and were given an envelope that contained either the entire $6, an even split of $3 or nothing. Each recipient then received a second envelope with $6 that they could share with other, unknown people and were instructed to place an amount into that envelope. Those who received either the $6 or the $3 in the first envelope weren't any more or less generous with the amount they placed in the second envelope. But those in the group that received nothing -- essentially the victims of greed -- were more apt to put nothing in the second envelope, thus cheating out future recipients.
Researchers conclude that people respond more powerfully to negative actions than positive ones and are more likely to pass along that negativity.
Given the recent history of Ponzi-scheme scandals such as those perpetrated by Bernard Madoff, the backlash against the so-called 1 percent wealthiest Americans and the fallout associated with the largest Wall Street banks, it seems we could use more high-profile examples of extravagant generosity.
Keep up with your wealth and mortgages and follow me on Twitter.
Get more news, money-saving tips and expert advice by signing up for a free Bankrate newsletter.
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Within the USA only please (Unless you want to pay for shipping)
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All these discs are Brand New and NEVER thrown,
All money goes to my tournament/league fund, thank you!
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The VictimLogic puzzles require you to think. You will have to be logical in your reasoning.
One of four people - two men (Jack and Mike) and two women (Carol and Lily) - was murdered.
The following facts refer to the people mentioned:
(a) Jack's sister argued exactly once with Carol's legal husband after the murder.
(b) Mike's sister argued twice with the victim's legal spouse after the murder. Who was the victim?
AnswerMike is the victim.
If Mike's sister and Jack's sister are the same person, then (a) reads "Lily argued exactly once with (Mike or Jack)" and (b) reads "Lily argued twice with (the same Mike or Jack)". These two statements contradict each other. Therefore Mike's sister must be different from Jack's sister.
If this is the case then there are two possibilities:
1) Jack and Carol are brother and sister. Mike and Lily are brother and sister. Jack is married to Lily and Mike is married to Carol. If this is the case, then (a) reads "Carol argued once with Mike" and (b) reads "Lily argued twice with herself", leaving Jack dead. Since Lily did not likely argue with herself, this is not the solution.
2) Jack and Lily are brother and sister. Mike and Carol are brother and sister. Jack is married to Carol and Lily is married to Mike. If this is the case, then (a) reads "Lily argued once with Jack" and (b) reads "Carol argued twice with Lily", leaving Mike dead. Since there are no contradictions, this is the solution.
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