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GlaxoSmithKline plc : albiglutide-data from five phase III studies
Monday 24 June 2013, London UK -- Data from five long-term Phase III studies (Harmony 1 to 5) comparing albiglutide, an investigational glucagon-like peptide receptor agonist (GLP-1), to placebo and a range of active comparators were presented at the American Diabetes Association Meeting (ADA) in Chicago (21-25th June). The active comparators in the studies were insulin, a sulphonylurea (SU), a thiazolidinedione (TZD), and a dipeptidyl peptidase four inhibitor (DPP-4). Albiglutide is not approved for use anywhere in the world.
The primary efficacy endpoint for these studies was the change from baseline in HbA1c compared to placebo and/or active comparators assessed after one or two years of treatment. Secondary endpoints included fasting plasma glucose (FPG) and weight. These studies were specifically designed to assess durability of albiglutide effect on HbA1c and other continuous variables when used in various combination therapies, at different stages of the disease, and in various degrees of renal impairment. Albiglutide achieved the primary efficacy endpoint in these five studies, although a hierarchical analysis of noninferiority to pioglitazone was not met in one study, as noted below. The most commonly reported adverse reactions in these studies were gastrointestinal (GI) complaints, primarily nausea and diarrhoea, and injection site reactions.
In Harmony 1 (Abstract number: 2013-LB-5644), a 3-year, 52-week primary endpoint, randomised, double-blind, placebo-controlled study, patients inadequately controlled on a current regimen of pioglitazone with or without metformin were administered either 30mg albiglutide or placebo. At the 52 week primary endpoint, albiglutide combination therapy demonstrated a statistically significant reduction in HbA1c from baseline compared to placebo (treatment difference of -0.8% (p<0.0001)). forty-four="" percent="" of="" the="" albiglutide="" patients="" achieved="" an="" hba1c="" target="" of="" less="" than="" 7%="" compared="" to="" 15%="" of="" those="" on="" placebo.="" there="" was="" a="" non-significant="" difference="" in="" weight="" with="" albiglutide="" versus="" placebo="" (treatment="" difference:="" -0.2kg).="">Adverse events of nausea and vomiting were comparable between albiglutide and placebo, while diarrhoea (11.3% vs. 8.6%) and injection site reactions (11.3% vs. 7.9%) were higher for albiglutide vs placebo. The rate of severe hypoglycaemia in the albiglutide arm of the study was 1%.
Harmony 2 (Abstract number: 2013-LB-5749), a 3-year, 52-week primary endpoint randomised, double-blind, placebo-controlled study compared albiglutide 30mg or 50mg vs placebo in patients on diet and exercise in drug naïve patients. At 52 weeks, both albiglutide doses demonstrated statistically significant HbA1c reductions over placebo (-0.84% 30mg albi; -1.0% 50mg albi; p<0.0001). weight="" (kg)="" decreased="" in="" all="" groups="" (-0.9/-0.4/-0.7kg="" placebo/30mg="" albi/50mg="" albi).="" gi="" adverse="" event="" rates="" for="" nausea="" (8%/10%/9%),="" diarrhoea="" (12%/10%/13%)="" and="" vomiting="" (1%/3%/3%)="" were="" similar="" across="" placebo/albi30mg/albi50mg,="" while="" injection="" site="" reactions="" (10%/18%/22%)="" were="" higher="" in="" the="" two="" albiglutide="" arms.="" there="" were="" no="" reports="" of="" severe="" hypoglycaemia="" in="" the="" albiglutide="" arm="" of="" the="">
Harmony 3 (Abstract number: 2013-LB-5750)was a 3-year, 104-week primary endpoint, randomised, double-blind, placebo- and active-controlled, parallel-group study comparing the efficacy and safety of albiglutide, sitagliptin, glimepiride, and placebo in subjects taking and inadequately controlled on metformin. At Week 104, the reduction in HbA1c was statistically significant in the albiglutide group compared to those treated with placebo(-0.9%; p<0.0001),>sitagliptin (-0.4%; p=0.0001),orglimepiride (-0.3%; p=0.003). Weight loss in the albiglutide group was statistically significant compared to the glimepiride group (-2.4kg; p<0.0001) and="" similar="" to="" the="" sitagliptin="" (-0.4kg)="" and="" placebo="" (-0.2kg)="" groups.="">GI adverse events during 2 years of observation included nausea (11%/7%/6%/10%), vomiting (1%/4%/4%/6%) and diarrhoea (11%/9%/9%/13%) across the placebo/sitagliptin/glimepiride/albi arms; injection site reactions were (5%/6%/8%/17%), respectively. There were no reports of severe hypoglycaemia in the albiglutide arm of the study.
In Harmony 4 (Abstract number: 2013-LB-5751),a 3-year, 52-week primary endpoint, randomised, open-label study, albiglutide was compared to insulin glargine, in subjects on metformin with or without an SU. Both groups achieved a similar reduction in HbA1c (-0.7% and -0.8% in the albiglutide and insulin glargine groups). Treatment difference 0.11% with 95% CI (0.04%, 0.27%) indicates non-inferiority of albiglutide versus insulin glargine. Patients on albiglutide lost weight (-1.1kg) while those on insulin glargine experienced weight gain (+1.6kg) with a treatment difference of 2.6kg (p<0.001).>GI adverse events though week 52 for albiglutide/glargine arms included nausea (9.9%/3.7%), vomiting (3.8%/3.7%) and diarrhoea (7.5%/4.1%). Injection site reactions were higher for albiglutide vs. glargine (13.9% vs. 8.7%, respectively). The rate of severe hypoglycaemia in the albiglutide arm of the study was 0.4%.
The Harmony 5 study (Abstract: 2013-LB-5752) was a 3-year, 52-week primary endpoint, randomised, double-blind study to evaluate the efficacy and safety of albiglutide compared to placebo and pioglitazone (pio) in patients currently on a background therapy of metformin and glimerpiride. Stepwise statistical analysis was first versus placebo, followed by noninferiority (margin 0.30%) testing vs pio. At Week 52, the reduction in HbA1c in the albiglutide group was statistically significant versus the placebo group (-0.9%; p<0.001). non-inferiority="" was="" not="" achieved="" versus="" the="" pio="" group="" (0.3%;="" p="0.27).">GI adverse events at Week 52 for nausea (3.5%/4.3%/9.6%), diarrhoea (2.6%/5.4%/8.9%) and vomiting (0.9%/1.8%/2.6%) across the placebo/pio/albiglutide arms were higher for albiglutide, as were injection site reactions (3.5%/3.2%/12.9%). The rate of severe hypoglycaemia in the albiglutide arm of the study was 0.4%.
Data from one other Phase III study was also presented at the ADA meeting, Harmony 8 (68-OR), a 52-week controlled trial in which albiglutide was compared to a DPP-4 inhibitor, sitagliptin, in patients with renal impairment (results previously announced).
About the Harmony Phase III programme
The Phase III clinical development programme for albiglutide comprised eight individual studies (Harmony 1 to Harmony 8) involving over 5,000 patients. The programme investigated the efficacy, tolerability and safety, including cardiovascular safety, of albiglutide as mono- and add-on therapy, in patients with type 2 diabetes. All eight studies have completed.
About Albiglutide
Albiglutide, a GLP-1 receptor agonist, is an investigational biological product for the treatment of type 2 diabetes designed for once-weekly subcutaneous dosing. GLP-1 is a peptide that is normally secreted from the gastrointestinal tract during a meal which in turn helps release insulin to control blood sugar elevations after eating. In people with type 2 diabetes, GLP-1 secretion in response to a meal is reduced or absent. Albiglutide is currently undergoing regulatory review for the treatment of type two diabetes in the US and European Union.
V A Whyte
Company Secretary
24 June 2013
GlaxoSmithKline- one of the world's leading research-based pharmaceutical and healthcare companies - is committed to improving the quality of human life by enabling people to do more, feel better and live longer. For further information please visit www.gsk.com.
GlaxoSmithKline Enquiries:
UK Media enquiries:
David Mawdsley
+44 (0) 20 8047 5502
Simon Steel
+44 (0) 20 8047 5502
David Daley
+44 (0) 20 8047 5502
Catherine Hartley
+44 (0) 20 8047 5502
US Media enquiries:
Stephen Rea
+1 215 751 4394
Kevin Colgan
+1 919 483 2933
(North Carolina)
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+1 919 483 2510
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+1 919 483 0492
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+1 202 715 1048
(Washington, DC)
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+1 215 751 5664 (Philadelphia)
Analyst/Investor enquiries:
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+ 44 (0) 20 8047 3289
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+ 44 (0) 20 8047 2406
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+ 1 215 751 7002
Cautionary statement regarding forward-looking statements GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Factors that may affect GSK' s operations are described under Item 3.D 'Risk factors' in the company's Annual Report on Form 20-F for 2012.
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From the moment you switch this monitor on, its colour performance is impressive. This can be attributed to HP's new generation of panels designed with improved colour performance in mind. In our tests, it had saturated and punchy colours.
Although the maximum brightness on this monitor is low, the wider contrast range means that the performance is excellent. Uniformity is also good, with no grey areas.
Usefully, the LP3065 includes three DVI sockets, which means that it's easy to share it between two desktops and a laptop.
As is standard, gamma, contrast and other video basics are all set by the graphics card, and not synthesised in the monitor, and accessories are limited to a single USB hub. The LP3065 can be detached from its stand and mounted on a VESA standard arm.
However, the requisite quick-release catch isn't provided in the box. Video performance was okay, with some noticeable smearing, although worse than you get with comparible products.

subset: commoncrawl


text: NOT the WHOLE place! I most certainly did not.. I'd actually say about a third of the crowd led by A55 and G2. I completely agreed with him coming out and definitely wasn't going to change to bring him back after I saw his reaction. I'm glad he came to his senses after he had a chance to think about it. I thought it was kind of immature to chant to bring him back in.


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New strategies exist for lactose intolerance, which should help a substantial number of people consume more dairy products.
In a national sample of 3,452 adults, one out of eight — or 12.3 percent — perceived themselves to be lactose intolerant, according to this recent issue of The American Journal of Clinical Nutrition.
Besides the total number of people involved, there are misperceptions surrounding lactose intolerance, Karen Kafer, vice president of health partnerships and communications for the National Dairy Council, told those attending a lactose intolerance webinar on Tuesday.
For most people affected, dairy products can be part of a healthy diet, pointed out Roberta Duyff, a nationally recognized food and nutrition consultant. "Most people with lactose intolerance can enjoy three servings of dairy every day without unpleasant GI (or gastrointestinal) symptoms," she said.
She cited the following statement from Melvin Heyman, a physician with the American Academy of Pediatrics:
"Treatment of lactose intolerance by elimination of milk and other dairy products is not usually necessary given new approaches to lactose intolerance…"
Among those new approaches:
- Include milk with other foods in a meal. "Mixing milk with other foods, such as soups and cereals, will ease digestion," Duyff said.
- Consume live-culture yogurts.
- Choose natural cheese with minimum amounts of lactose.
- Try milk products with reduced lactose or zero lactose.
- Ease into it if you haven't been consuming dairy. One of the speakers at Tuesday's webinar, Dr. Robert Heaney, professor of medicine at Creighton University, suggested starting off with half a serving of dairy with each meal. "It may take two or three weeks for the gut to adapt and build up tolerance," he said. "Just stick with it and you will get there quicker than you realize."
Dr. Heaney emphasized the nutritional advantages of dairy products.
"Milk is more than calcium," he said. "It contains a whole host of other things that will improve your diet quality substantially."
For instance, milk contains three of the nutrients — calcium, vitamin D and potassium — that are often under-consumed by people, given the nature of today's diets and eating habits. If people cut dairy products out of their diets, they will get even less of these essential nutrients.
Dairy is also a source of high-quality protein, Dr. Heaney said. Indeed, dairy tops the list for having the best nutrient value for calories consumed, he said.
Tuesday's webinar was jointly sponsored by the National Dairy Council and Creighton University Health Sciences Continuing Education. The webinar was intended for physicians, dietitians and other health professionals.


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Martian Passport Smartwatch - RGB LED Light, Caller / Text ID - MP100WSWItem#: 13795259 | Model#: MP100WSW
Currently Out Of Stock!
Martian Passport Smartwatch Product Details
Martian Passport Smartwatch
Merge class with technology when you use the Martian Passport SmartWatch - White/Silver/White. This SmartWatch is compatible with most of the latest Android and Apple devices. It connects to your device using its Bluetooth 4.0 technology. It allows you to make and answer calls, send texts, create events, and more using its noise cancelling microphone and directional speaker. Its OLED Display shows caller information, Text readouts and more at 96x16 pixels while the RGB LED light & Soft Touch Vibration notify you of your incoming calls and messages. The rechargeable Lithium-Polymer battery gives the watch a 7 day standby life and over 2 hours of talk time. It can be recharged in just two hours through the Micro USB port. It is made of a Stainless Steel Casing, Scratch resistant glass crystal, fire retardant resin back plate and white leather belt. It also has a Quartz analog watch with a battery that lasts up to 2 years. Buy the Martian Passport SmartWatch - White/Silver/White today!
What It Is And Why You Need It:
- Bluetooth 4.0; easily connects your phone to the smartwatch to enable you a world of features
- Android/Apple Compatible; works with most of the latest Android and Apple Devices
- Lithium-Polymer Battery; gives it 7 days of standby life and over 2 hours of talktime
- Noise Cancelling Mic with Directional Speaker; use as hands free for calling texting and more
- Strong Classy Design; made of Stainless Steel Casing, Scratch resistant glass crystal, fire retardant resin back plate and white leather belt
The Perfect Hands-Free Partner to Your Smartphone
Theres no need to touch your phone when your hands are full or youre busy in a meeting or driving. See whos calling, read incoming messages, and even talk and listen from your wrist with the new line of Martian Voice Command Watches. Now you can keep your phone in your pocket or bag and stay connected with the world.
Freedom comes in a stylish timepiece that lets you access your smartphones voice command functions from your Martian Watch. Now youre armed with a clear, directional speaker and noise-canceling microphone on your wrist.
Place calls, send voice-to-text SMS messages, listen and respond to text messages, set calendar notifications, control music, search the web, set reminders and calendar appointments by using the familiar voice command functions integrated into your smartphone - all from the comfort and convenience of your watch. Now thats an impressive smartphone experience!
Manufactured by: Martian Watches
Warranty provided by: Martian Watches
UPC No: 854940002170
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Deep treads and toothy lug patterns give you traction in dirt, sand, and over roots and rocks so you can safely run uphill and down.
Rigid toe guards, rock plates, and Gore-Tex or waterproof breathable uppers save your feet from impact, sharp obstacles, and wet weather.
Trail shoes are split into four categories: motion control, stability, neutral (or cushioning), and minimalist. Some trail shoes offer added medial posting or cushioning for particularly harsh off-road running.


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AAJ seeks to encourage law students to learn about trial advocacy skills and what it takes to be a trial lawyer. We host an intramural mock trial tournament during the academic year. Students learn to prepare and present a case, usually in a courtroom setting before practicing San Diego attorneys and judges.
American Association for Justice (AAJ)
Organization Contact
Jillian Ewan


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I'll use sleepys scale.
10- Never thrown, no ink, brand new condition
9- Field tested or used for one or two rounds
8- Lightly used with very minimal wear
7- Used with some minor dings or scuffs but still in good shape
6- Typical used disc with the usual dings, scratches but still worthy
5- Kinda beat, significant wear, has lost a good bit of it's stability
4 - Beat up turnover disc with some evident war story wear
3 or under- Beat to Hades dog chew toy
Blue CE Teebird - 171g - with my pdga # in the inside rim.
it has been used for a total of 3 rounds (54 holes) back when i was learning disc golf. Hasnt left the box in a couple of years now.
I would rank this an 8, Super 8 due to a scuff from an ace run and my pdga tat on the inner rim.
I'm taking it out to settle a bet with JWT4412
Trotter says that he doesn't think I could get $50 for a blueberry C.E. Teebird - I think he is wrong...
Am i right or is he wrong?


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Creation often involves human invention and imagination. It is a concept that breeds originality and expression, and nothing embodies the spirit of creation like a Lowrider! Add the words "One and Bad" in front of "Creation," and you have the name of one of the top clubs in Lowriding; One Bad Creation car club. Formed in the San Fernando Valley area of Southern California in 1989, this club of tightly knit Lowrider enthusiasts sought out to make their mark on the Boulevard with creativity, passion, and solidarity. In fact, "One Bad Creation" was chosen as a club name because it could represent every member's car perfectly. Whether in theme, concept, or execution, the founding members had the foresight to know that every car in the club would eventually end up being "One Bad Creation!"
The club has had no problem backing up their name with quality builds over the years, as its members have produced a number of both full show cars and street cars. A few of the club's cars have graced the inside and cover pages of Lowrider Magazine over the years as well. Although the club is easy going on the requirements for membership, the prospective members build their rides to uphold the standards of the club, focusing on the fundamentals of having a nice paintjob, a top notch interior, and plenty of chrome all around. Like it says on the club's lower rocker on their plaque, the club has rides from "Mild to Wild," and each is "One Bad Creation."
Among the club's previous LRM features, Cleto Sanchez was a 2008 centerfold feature with "Black Widow," his 1961 Chevy Impala ragtop. Ricardo Alvarado's 1987 Buick Regal "El Invisible" was featured in 2009, and Manual Martinez' 1976 Chevy Caprice was the January 2011 cover feature. The always-active club has also been featured in Lowrider Magazine show coverage as well as in other automotive publications.
The club's accolades don't stop at magazine coverage either. Plenty of trophies have adorned the club's rides as well. Members' cars have won Best Lowrider and Best Lowrider truck at shows dating back as far as 1988. Cleto's '61 Impala has won numerous awards on its own, including Best Traditional at shows in San Diego, San Bernardino, and Phoenix, Arizona. Cleto's '63 Impala took Best Candy at the 2002 Lowrider Magazine show in Fontana, California. Manual's Caprice won best interior at the 2010 Las Vegas Super Show. America, (Gabriel's daughter) was awarded best three-wheeler and third place sweepstakes with the "Diablita" at the 2010 Las Vegas Super Show.
Currently, President Cleto Sanchez and Vice President Jaime Anaya, who guide the club with the bylaws that have been in place since 1989, head the club. As Jaime stated, "Everyone in the club is treated equally, and all decisions are ruled by the majority." The members always vote as a club on decisions pertaining to the club. The officers of the club keep the members motivated and active by helping them to work on their cars, organizing club events, and asking for input on club issues. There are currently twenty active members in One Bad Creation, but they have had as many as 30 members at one time. The majority of the members are from cities in the San Fernando Valley area, like Sylmar, Granada Hills, Canoga Park, and Reseda, but they also have members from Glendale, La Puente, and Las Vegas, Nevada. Many of the members have multiple cars, but the club's focus has always been quality over quantity.
Family is also a prime focus for the club, with about 90 percent of the club's members being married with children. Many of the members' children have their own pedal cars and Lowrider Bicycles that sport the One Bad Creation car club plaque. The club also includes the family in all of its outings, bringing everybody to the car shows they attend in Southern California, Northern California, Arizona, and Nevada.
Thanks to their twenty-two year tenure and one chapter formation, "One Bad Creation" will continue to make their mark on the culture for years to come. They insist on remaining a one-chapter club as well, despite the fact that "they are scattered everywhere," as one member happily explained. A good percentage of the members have been in the club for over ten years. Vice President Jaime Anaya and club member Albert Raygosa have been members for 17 years. With years of membership and a commitment to family, solidarity, and creativity, there is no question that the club will be around for a long time, supporting the Lowrider culture by creating history; one bad creation at a time.


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10 Celebrities With Blond Hair
The 10 Best Blondes in Hollywood
The 10 Best Blondes in Hollywood
We're happy to present this article from one of our favorite sites, Real Beauty.
We've rounded up our top 10 fave celebs (in each hue) when it comes to bold, envy-enducing, sexy hair. Now it's your turn to comment and tell us whose locks you're lusting after most.
More stories from RealBeauty.com:
A Guide to the best Makeup and Hair Brushes
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The Chicago Blackhawks are closing in on an NHL record.
At 12-0-3, they've become one of three teams to start a season with a point in at least 15 consecutive games.
The record is held by the 2006-07 Anaheim Ducks, who ran their streak to 16 games before suffering a regulation loss. The 1984-85 Edmonton Oilers had a 15-game streak to start the season.
Despite the opportunity to reach a milestone (they take on the rival Vancouver Canucks on Tuesday), the Blackhawks aren't focused on the mark.
"What's important to us is getting home-ice advantage, making the playoffs," Chicago captain Jonathan Toews said, according to The Associated Press. "Those are our goals. Once you get there, the real season starts.
"When you get to that point, no one really cares or remembers those streaks at the start of the season."
One thing of note: The Oilers and Ducks went on to win the Stanley Cup in those seasons.


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(Updates story to say 2012 returns totaled 7.9%.)NEW YORK ( TheStreet) -- Hedge fund manager David Einhorn of Greenlight Capital said Wednesday that ratings agency Moody's ( MCO) was his biggest money-losing short bet last year. As Einhorn made little mention of the short position -- betting on a decline in Moody's share price -- in numerous investor reports and media appearances, the famed short seller's comments raise a crucial question. Should you trust David Einhorn? It's a relevant topic, given his front-page battle with Apple ( AAPL) over the iPhone and iPad maker's management of its purse strings. Meanwhile at investor conferences, Einhorn's been able to dramatically swing stocks when announcing new trades, such as recent short positions in the likes of Chipotle Mexican Grill ( CMG) and materials giant Martin Marietta ( MLM). Consider Einhorn's fourth-quarter letter to investors, which highlighted a souring of Greenlight's investment in Apple, a burned bet against coffee maker Green Mountain Coffee Roasters ( GMCR) and a wrong-way trade in Marvell Technologies ( MRVL), among a handful of positions that caused the fund to fall in the quarter. A 2012 gain of 7.9% put Greenlight below the overall market. "Our coffee was too hot, our apple was bruised, and our iron supplements didn't go down smoothly. We got to marvel at a jury's decision to endow a university with a billion dollar verdict, and tried not to get too moody when several of our shorts melted up," Einhorn said in the fourth-quarter investor letter. In the letter, Einhorn highlighted the short bet in Green Mountain Coffee Roasters as a problematic 2012 trade in the company's short portfolio. "The losses in the short portfolio were broad-based; while the S&P 500 was down modestly in the quarter, our average short rose about 10%. Green Mountain Coffee Roasters was the worst offender, with a 74% advance that wiped out our 2012 profits on the position," Einhorn wrote in a Jan. 23 investor letter. As it turns out, Einhorn may have been most "moody" because of a long-running bet against ratings agency Moody's stock, which gained nearly 30% in 2012. "Our biggest loser on the short side last year was Moody's," Einhorn said Wednesday on a conference call for Greenlight Re ( GLRE), an insurer affiliated with the hedge fund. A look through Greenlight's previous 2012 quarterly investor letters shows little mention of Greenlight's short position in Moody's, other than perhaps the subtlest mention. Prior to Wednesday, Einhorn's most recent direct reference to the trade came in response to an audience question at an October investor conference.
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- Parents want to know that a sports program is safe for their children. Having specific policies that address these issues will increase parent trust and confidence in club leadership, coaches, or ownership.
- Athletes can concentrate on their sports, without second-guessing their "gut feeling" that someone's behavior isn't right.
- Clear rules and a fair process reduce the Club's risk from lawsuits that may be filed by dismissed coaches or the abused victim or her/his family.
- Many national sport governing bodies (NGB) do not yet require their Club members to have comprehensive athlete protection policies, and if they do, these policies may not address bullying or coach/peer athlete conduct that falls short of criminal behavior.
- Even when NGBs have processes that are applicable in cases of athlete sexual abuse, reporting and investigation procedures take a considerable amount of time and because the NGB is not the employer, the NGB in not in a position to address immediate suspension of an employee in the case of serious misconduct.
The local Club is responsible for the safety of its program participants and is obligated to take immediate action to remedy a hostile environment.


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May 15, 2013
CitySole.com have sent in some great photos of the recently releases Spiz'ike for Women. The first of its kind, this limited colorway consists of black and ice blue with dabs of pink. As far as Women colorways go, its on the tougher side with only small lashings of the 'compulsory' pink.
This one truly is just for the ladies. A great combination of black suede and patent leather mixed with bright ice blue and the always vibrant pink fire is sure to break necks as the first Womens Spiz'ike. What do you think ladies? We're keen to hear your feedback, maybe a lace flip is in order? Either way don't sleep on these, to pick up a pair hit CitySole.com for a huge range of kicks and some of the best prices you'll find.
Women's Air Jordan Spi'zike
Black/Pinkfire-Ice Blue


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Health and Safety Podcast Transcript: Sept. 4, 2013
Hello, and welcome to the Fairfax County Health and Safety Podcast. I'm Jim Person, Fairfax County emergency information officer. Coming up, learn about National Preparedness Month, home fire safety and being safe on the roads near school zones. Links to topics mentioned in this podcast can be found online at www.fairfaxcounty.gov.
September Is National Preparedness Month. It's no secret that disasters, both natural and man-made, seem to be occurring more frequently in the U.S. and locally. National Preparedness Month is the perfect time to get ready for whatever may come, including tropical storms, hurricanes, extended power outages and other types of events. You may think that it takes a lot of time and money to be prepared, but preparing for emergencies doesn't have to cost a lot of money – and can be done in a few easy steps.
- First, make a plan. It doesn't have to be a novel – just something everyone in your family can understand and remember.
- Second, set aside some emergency supplies, including enough food and water – enough for each person in your home to last for at least three days.
- And, be sure to review your insurance policies to make sure you're adequately covered.
You can find lots of easy-to-accomplish preparedness tips on the Fairfax County emergency blog at www.fairfaxcounty.gov/emergency/blog. Look for the " 30 Ways to Prepare" link under the "Prepare" tab at the top of the page.
Nearly 2,500 people die in home fires each year. Eighty-two percent of all fire deaths and 76 percent of all fire injuries in our country occur in the home – the very place we should feel most safe. Remember, in the event of fire, every second counts. Everyone should make and practice a home escape plan. If you have decreased mobility or a visual or hearing impairment, talk with your family members, building manager or neighbors about your fire safety plan and practice it.
- Make sure that your house number is clearly visible from the street using numbers that are at least 4 inches high.
- Have at least two exits from every room and know how to open locked or barred doors and windows.
- Contact your local fire station. The Fairfax County Fire Department will provide a courtesy home inspection, review your escape plan and even install smoke alarms if necessary.
- If you encounter smoke, stay near the ground or crawl low to an exit. Once outside, stay out and call 9-1-1 from a neighbor's house.
- If you are trapped in a room or do not feel that you can escape safely, close the door between you and the fire. Use a blanket or sheet to fill the gaps around the door to keep smoke out. Then, signal out the window using a blanket or sheet.
For more fire safety information, visit the U.S. Fire Administration's website at www.usfa.fema.gov and the Fairfax County Fire and Rescue Department at www.fairfaxcounty.gov/fr.
Fairfax County Police urge motorists to be extra vigilant for pedestrians and bicyclists as county schools resumed classes Sept. 3. Commuters should expect increased congestion throughout the first few weeks of school, so build some extra time into your schedules to accommodate this traditionally heavy time period. Residents may also notice police officers posted in school zones and near bus stops helping ensure pedestrian safety as well as safe loading and unloading of students. Police remind drivers that when bus lights and stop signs are activated, vehicles must stop in both directions, unless they are separated from the bus by a median. For more, visit www.fairfaxcounty.gov/police.
Finally, be sure to subscribe by RSS or email to the county's emergency information blog at www.fairfaxcounty.gov/emergency/blog for the latest preparedness news.
That's it for this edition of the Fairfax County Health and Safety Podcast, produced by the Fairfax County, Va., Government. Thanks for listening. Additional information about health and safety topics and emergency preparedness may be found online at www.fairfaxcounty.gov. And remember, if you have a police, fire or medical emergency, call 9-1-1. For non-emergency needs, call 703-691-2131.


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on the realgm.com website there is a mock draft article. the article states a rumor that atlanta and NO may work out a draft day deal. Al and the #2 would go to NO for magloire and the #4. There would obviously have to be cap filler involved, but I thought it was interesting none the least.
"4.) New Orleans Hornets : Chris Paul, PG, Wake Forest, So.
There have been some Hornet rumors that have them trading center Jamaal Magloire and this pick to the Hawks for the #2 and Al Harrington. Im not sure if that works under the CBA trading rules right now because Magloire is a base-year player, meaning that his contract doesnt escalate with each passing year, so his cap number is different for him. If the rumors arent true, then Paul still is the best choice right here. He and J.R. Smith would be one the best scoring and most exciting backcourts in the league, even if only 8,00 people in New Orleans will be watching. "


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A Study to Investigate the Efficacy and Safety of GSK1605786 for Treatment of Patients With Active Ulcerative Colitis
This study has been withdrawn prior to enrollment.
(Study CCX115383 has been terminated prior to enrolment of any patients. A decision was made by GSK to delay pursuit of this indication as the biology evolves.)
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: May 24, 2012
Last updated: June 20, 2013
Last verified: June 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
GSK1605786 is an oral antagonist specific for the chemokine receptor CCR9 in development for treatment of small bowel and colonic Crohn's disease (CD). The purpose of this Phase II proof of concept study is to investigate the efficacy and safety of GSK1605786 (500 mg twice daily) administered orally for 16 weeks for the treatment of patients with active ulcerative colitis (UC). A key secondary objective is to understand the mechanism by which GSK1605786 is acting and to this end samples will be collected to confirm the degree of inhibition of CCR9 on T lymphocytes in the blood of patients, and to explore the relationship between concentration of drug and changes in lymphocyte and antigen presenting cell populations in the peripheral circulation and in the colon. Patients recruited at specified investigational sites will be invited to participate in an optional sub-study to explore the effects of GSK1605786 on trafficking of technetium labelled T cells using Single Photon Emission Computerized Tomography (SPECT). Specifically, the technique will be used to follow trafficking to large intestine and thymus and findings linked to pharmacokinetics of GSK1605786, receptor occupancy and clinical efficacy outcomes
|Colitis, Ulcerative
|Drug: GSK1605786 Other: Placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Phase II, 20-week, Multi-centre, Randomised, Double-blind, Placebo-controlled, Parallel Group Proof of Concept Study to Investigate the Efficacy and Safety of GSK1605786 for Treatment of Patients With Active Ulcerative Colitis
Resource links provided by NLM:
Genetics Home Reference related topics: ulcerative colitis
MedlinePlus related topics: Ulcerative ColitisU.S. FDA Resources
Further study details as provided by GlaxoSmithKline:
Primary Outcome Measures:
- Efficacy of GSK1605786 at week 12 following twice daily administration at 500 mg in patients with active UC. [ Time Frame: 12 weeks ]Ordinal response (remission, response, or no response) to treatment as assessed by the MAYO score at week 12.
Secondary Outcome Measures:
- safety and tolerability of GSK1605786 in patients with active UC following repeat dosing continued for up to 16 weeks [ Time Frame: 16 weeks ]Adverse events (AEs), Treatment effects on blood pressure, heart rate, electrocardiography (ECG) parameters and haematology, clinical chemistry and urinalysis findings
- The time course of the efficacy of GSK1605786 [ Time Frame: 16 Weeks ]Incidence of remission (MAYO score ≤ 2 with no individual subscale exceeding 1) at Week 12, incidence of response (MAYO score decreased for ≥ 3 points in comparison with baseline) at Week 12, change in partial MAYO score compared to baseline through week 16, change in SCCAI score compared to baseline through week 16, incidence of endoscopic remission (mucosal healing) rate at Week 12 (defined as proportion of patients with endoscopy score of 0 or 1 on the MAYO endoscopic sub-scale) and time to withdrawal and/or use of rescue medication
- The anti-inflammatory activity of GSK1605786 in patients with active UC [ Time Frame: 16 Weeks ]Circulating soluble biomarkers (CRP, CXL10), faecal calprotectin levels, receptor occupancy (CCR9 internalization).
- The effects of GSK1605786 on quality of life in patients with UC [ Time Frame: Baseline, week 12, week 16 ]Quality of Life (IBDQ) Questionnaire.
- The systemic pharmacokinetics (PK) of GSK1605786 following twice daily administration at 500 mg in patients with active UC. [ Time Frame: DaysBaseline, week 4, week 8, week 12, week 16 ]The maximum observed concentration (Cmax) on Day 28; Trough concentration (Cτ) on Day 28; Plasma clearance and volume of distribution estimated based on population pharmacokinetic analysis of healthy volunteers (historical data) and patient data, if possible
- CCR9 occupancy (RO) in peripheral blood [ Time Frame: 12 Weeks ]TECK/CCL25 and CCR9 expression in colon biopsy at baseline and at 12 weeks
|Study Start Date:
|February 2013
|Estimated Study Completion Date:
|December 2014
|Primary Completion Date:
|February 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: GSK1605786
Administered orally for 16 weeks in a 2:1 ratio
Other: Placebo
500 mg twice daily administered orally
Placebo Comparator: Placebo
Administered orally for 16 weeks in a 2:1 ratio
Drug: GSK1605786
500 mg twice daily administered orally
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female aged 18 and over at the time of signing the informed consent.
- A female subject of child-bearing potential is eligible to participate if she agrees to use one of the contraception methods listed in Section 8.1 for an appropriate period of time (as determined by the product label or investigator) prior to the start of dosing to sufficiently minimize the risk of pregnancy at that point. Female subjects must agree to use contraception until completion of the follow-up visit.
- Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form, prior to any of the screening procedures including discontinuation of prohibited medication.
- At screening (visit 1): patients with a clinical history and examination suggestive of active UC for at least 3 months despite at least 2 weeks treatment with oral >2.4g/day mesalazine / mesalamine or equivalent.
At screening/randomization (visit 2):
- Presence of active UC spread beyond the rectum (inflammation extending ≥ 15cm from anal verge) as evidenced by flexible sigmoidoscopy or colonoscopy during the screening window.
- AND MAYO score of 5 - 10 inclusive.
- AST and ALT < 2xULN; alkaline phosphatase and bilirubin ≤ 1.5xULN (isolated bilirubin >1.5xULN
Exclusion Criteria:
- If female, is pregnant, has a positive pregnancy test or is breast-feeding.
- Confirmed diagnosis of celiac disease, those who follow a gluten-free diet to manage symptoms of suspected celiac disease and subjects with positive serologic test for Tissue transglutaminase, tTG.
- Subjects who have received immunisation with a live vaccine e.g. measles, mumps, rubella (each as in MMR vaccine), oral polio, varicella, yellow fever, within 4 weeks of screening and throughout the study, with the exception of influenza vaccine.
- Known or suspicion of CD, indeterminate colitis, microscopic colitis, ischaemic colitis or radiation-induced colitis, based on medical history, endoscopy and/or histological findings.
- Subjects with imminent need for surgery for UC in the opinion of the investigator.
- Subjects where assessment of MAYO score is likely to be confounded by previous surgery (for example colectomy, ileostomies, colostomies or rectal pouches).
- Subjects requiring enteral or parenteral feeding.
Use of prohibited medications within their specified timeframes (see Section 9).
- 5-Aminosalicylic acid enema: within 2 weeks of screening and throughout study
- Topical (suppository) 5-Aminosalicylic acid: at screening and throughout study
- Biologic use: within 12 weeks of screening and throughout study
- Corticosteroids use: Oral, rectal or parenteral corticosteroids within 4 weeks of screening and throughout study
- Antibiotics: Intravenous antibiotics within 8 weeks of screening and throughout study (oral antibiotics are permitted where they have been used for >4 weeks with stable dose for ≥2 weeks prior to screening)
- Probiotics: within 4 weeks of screening (patients who initiated probiotics or prebiotics more than 4 weeks prior to screening should continue use throughout study)
- NSAIDs: Within 7 days of screening and throughout the study (except low dose aspirin (≤325 mg/day) which may be continued for cardioprotection)
- Digoxin: or related cardiac glycoside (e.g. digitoxin, deslanoside, lanatoside C, metildigoxin) use at any time during screening and throughout the study.
- Known HIV infection
- A positive HBsAg, Anti-HBc, or Hepatitis C antibody result at screening or documented positive result within 3 months of screening.
- Known varicella, herpes zoster, or other severe viral infection within 6 weeks of screening.
Active or latent tuberculosis (TB) infection:
- The subject has a history of TB disease or latent TB infection, in the absence of documented adequate therapy for same.
- Suspicion of current TB disease (including extra pulmonary TB disease such as tuberculosis enteritis) or latent tuberculosis infection, as evidenced by positive QuantiFERON-TB Gold test, or T-SPOT.TB test.
- Current or chronic history of liver disease or known hepatic or biliary abnormalities including primary sclerosing cholangitis (with the exception of Gilbert's syndrome or asymptomatic gallstones).
QTc ≥450 msec (≥480msec for those with Bundle Branch Block).
- either QTcb or QTcf, machine or manual overread, males or females. The QT correction formula used to determine exclusion and discontinuation should be the same throughout the study.
- based on single QTc value of ECG obtained over a brief recording period.
- The subject has a concurrent illness or disability that may affect the interpretation of clinical data, or otherwise contraindicates participation in this clinical study (e.g., an unstable cardiovascular, autoimmune, congenital or acquired immunodeficiency, renal, hepatic, pulmonary, endocrine, metabolic, gastrointestinal, haematologic, or neurological condition or mental impairment).
- The subject has current evidence of, or has been treated for a malignancy within the past 5 years (other than localised basal cell, squamous cell skin cancer, cervical dysplasia, or cancer in situ that has been resected).
- Use of any investigational drug within 30 days, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer) prior to screening
- Medical history of sensitivity to any of the components of GSK1605786 (microcrystalline cellulose, colloidal silicon dioxide, crospovidone, magnesium stearate, gelatin).
- Prior exposure to GSK1605786: Any previous exposure to GSK1605786 (formerly ChemoCentryx compound CCX282-B).
- Known positive stool culture for enteric pathogens
- Positive immunoassay for C. difficile.
- Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period (with the exception of subjects involved in the optional scintigraphy sub-study, where no more than 700 mL of blood will be collected over the duration of the study, including any extra assessments that may be required).
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01658605
Please refer to this study by its ClinicalTrials.gov identifier: NCT01658605
|GSK Investigational Site
|Leuven, Belgium, 3000
|GSK Investigational Site
|Amsterdam, Netherlands, 1105 AZ
|United Kingdom
|GSK Investigational Site
|Cambridge, Cambridgeshire, United Kingdom, CB2 0QQ
|GSK Investigational Site
|Southampton, Hampshire, United Kingdom, SO16 6YD
|GSK Investigational Site
|Oxford, Oxfordshire, United Kingdom, OX3 9DU
Sponsors and Collaborators
|Study Director:
|GSK Clinical Trials
More Information
Keywords provided by GlaxoSmithKline:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01658605 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 24, 2012
|Last Updated:
|June 20, 2013
Keywords provided by GlaxoSmithKline:
ulcerative colitis
CCR9 antagonist
proof of concept
Additional relevant MeSH terms:
Colitis, Ulcerative
Gastrointestinal Diseases
Digestive System Diseases
Colonic Diseases
Intestinal Diseases
Pathologic Processes
Inflammatory Bowel Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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South Carolina mothers urging state's congressmen to support gun control legislation
Sun, 16 Jun 2013 14:49:19 GMT —
COLUMBIA (WACH) -- A group of South Carolina mothers is sending Father's Day gifts to the state's congressman, urging them to support gun control legislation.
Over the past week, members of Moms Demand Action for Gun Sense in America have been making neckties from yarn and paper that read "I have Gun Sense."
Organizers say they'll also send a card either thanking the congressman for his votes on gun control legislation or asking him to consider the group's position.
Last month, group members held a rally at the Statehouse to honor people killed by gun violence. They also released a Mother's Bill of Rights, which lays out rights that the moms want to protect their kids from guns.


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SHEPHERDSVILLE - Shepherdsville native Ida Wrocklage began battling one her biggest foes in life, ulcer colitis or inflammation, at an early age. She was diagnosed with ulcerative colitis at 13.
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Tucson dance instructor arrestedPosted: Updated:
Police say a dance teacher at a Tucson high school has been arrested on suspicion of sexual conduct with a minor.
Tucson police say they're investigating whether 28-year-old Charlie Luna engaged in inappropriate relationships with other underage girls.
The Arizona Daily Star says an administrator from another school contacted police after learning of an alleged relationship between Luna and a then 14-year-old girl.
Police say Luna and the girl knew each other through a dance studio where she takes classes.
Luna was an independent contractor working as an instructor at Sahuaro High School.
TheTucson Unified School District says the teenage girl isn't a district student.
Police say Luna was booked into Pima CountyJail on Nov. 27. They didn't immediately provide information on whether Luna has a lawyer.
Copyright2011 Associated Press. All rights reserved.


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I came across a disc today that looks like someone covered it in plasti-dip. Im guessing it's lower speed driver pretty domey and the rim isn't as wide as my wraiths. It flies well and it has a great grippy feel to it.
I am wondering if it is actually legal to play with a disc that has been coated in another material that still falls within legal weights?


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"It's as if the basketball gods have spoken. The Cavaliers signed restricted free agent center Iakovos "Jake" Tsakalidis (pronounced SOCK-a-lead-is) to a three-year offer sheet worth an estimated $9 million on Thursday. The Grizzlies have 15 days to match the offer."
"The Heat hopes to sign veteran free agent forward Christian Laettner in the next few days, several sources said. Laettner, 35, who was released by Golden State on Thursday, has expressed interest in joining Miami but has other options, according to a league source. Miami can offer the veteran's minimum ($1 million), while several other teams could offer more. The Warriors are responsible for his $6.2 million salary for next season."


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Welcome to WellPlayed 2.0
WellPlayed has been around for over a year now, and the eSports scene has changed a lot since then. We are an ambitious lot here; we wanted our site to be everything for everyone all the time. What that left us with was a site that was good at a lot of things, but not great at any one thing. As we continued working, we were able to recruit a small but fierce team of people who loved eSports of all kinds. As the months went by, we began to realize that we had two elements of our site that stood out: articles and stream viewing. With WPTV we had created a strong platform for viewers to watch an enormous variety of streamed content. With our writing we had found a unique voice and point of view within the eSports community. Our site had great content, but we weren't set up to highlight it. There was no easy way to find the work we were putting out, nor was there an easy way to cultivate a platform for the community at large to participate. That needed to change.
That brings us to WellPlayed 2.0. A site designed from the ground up to become a steady source of quality content for the eSports community. There are a lot of groups providing coverage right now; some of it is written and some of it is recorded, and much of it is in the same vein. On the one end of the spectrum there are in-depth match recaps being written on sites like Team Liquid, and on the other there are the beginnings of true eSports investigative journalism through ESFI World and others. We want to fit right in the middle. Some days we might dabble on the either end of the spectrum, but right now with our manpower we can't sustain either of those models. So instead we'll just write. About what we like, what interests us, what we think matters. We invite you to read and comment, and from that our goal is to learn and improve.
The ultimate goal is quality over quantity. We won't rush to a headline if we don't have anything to contribute. WP 2.0 will have the flexibility to allow us to respond quickly if we have something to say, but we won't use that solely to drive traffic. Substance is our prime directive. We are looking at organizations like the New Yorker, the Atlantic, and Penny Arcade Report as our inspiration. We want to bring how they do what they do to eSports as best we can. It won't happen overnight, but we want to start working on it and see where it goes, and with your help, we'll get there.
We're hoping this will be the beginning of more great things from WellPlayed. Coming soon will be a redesign for WellPlayed TV (which is of course integrated into our redesign) to improve the UI, stream sorting, and overall accessibility. We'd also like to get back to our roots and start running events, so look for more about that in the not-too-distant future.
Do you want to have your voice heard in the eSports community? WellPlayed is looking for skilled and motivated eSports aficionados who want to write articles! If you have an article you want to share, please email your pitch to [email protected].


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Home > Rooms & Cabins > Ponderosa > Sequoia
Sequoia – sleeps up to 5
2 Queens, 1 Twin, full kitchen, cable T.V., hairdryer & alarm clock, Northwoods decor, handcrafted log furniture, patio door to large covered deck with picnic table.
NEW in all Guestrooms!!!
- 42" large screen LED 1080p HD TV. Built on a strong reputation, LG is the leader in hospitality solutions for in-room entertainment. Their leading technology platforms are designed to enhance the guest experience with USB jacks and HDMI connectivity to view your vacation photos, connect a video game system, and other high-tech media uses.
- Custom built 805-coil InterAct Gel Foam-Encased 12.5″ Plush Mattresses for unbelievable comfort.
- And, don't forget to pack some DVD's to watch with the in-room DVD player.
Certain Saturdays may require a 2 or 3 night minimum stay. These 2 or 3 nights will be charged at the Sat Rate.


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Sturm Ruger (RGR) shares have dropped 22% in price in the past two weeks, partly as a result of Friday's massacre of mostly school children by a disturbed young man in Connecticut.
My feelings about this as a citizen and as an investment analyst are somewhat in conflict.
As a citizen, I think firearms should be licensed much the same way cars are. I advocate tighter gun control than we have now.
As an investment analyst, I think it is unlikely that my views will prevail. The nation did not enact strict gun control laws after the Columbine High School massacre of 1999, the Virginia Tech killings of 2007, or any of several fatal attacks that took place at schools.
Public indignation may be – indeed, should be -- especially high this time, because of the young age of the victims. But history suggests that the public anger won't translate into successful legislation.
President Obama has expressed dismay at the shootings and has said, "We can't tolerate this anymore. These tragedies must end. And to end them we must change."
I don't question his sincerity, but I don't believe that the Obama administration will make a major push for gun control at a time when the nation's budget and economy are hanging so much in the balance. In addition, the president's remarks may imply a need for better psychological counseling and early warning systems. Gun control isn't the only issue.
Sturm Ruger, the nation's largest manufacturer of rifles and handguns, would still have a business – in my opinion, a good business – even if gun control laws were tighter than they are now. However, stricter laws would slow the company's growth, which has been remarkable.
In 2011, Sturm Ruger's revenues grew about 29%, profits about 43%. For the past five years, the compound average earnings growth rate has been 42%. Over the past 10 years, Sturm Ruger shares have sold for a median level of 21x earnings. Today they sell for just under 15 times earnings.
The company has about $75 million in cash, no short-term debt and no long-term debt. Last year it earned a return on stockholders' equity of 39%, a remarkably high figure.
If you make your investment decisions objectively -- and if owning shares in a firearms manufacturer doesn't violate your personal ethical guidelines for investment -- Sturm Ruger is probably a good purchase now at about $46. Should it drop to below $40, perhaps because the gun-control discussion gets more serious, I think it would be an excellent value.


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French Organic Lavender Body Lotion 200ml
in Body & Beauty
Price: $25.00
Beautiful authentic Organic French Lavender scented body lotion. Made with aloe vera to easily absorb into the skin this beauty product leaves skin re hydrating, perfect to apply after a shower.
Aromatherapy Products - Responsible Practices
Green Credentials - Only 100% Green Energy is used in the creation of the Crystal Creek Meadows aromatherapy products range. All water is purified rainwater harvested on our Kangaroo Valley property on the South Coast of NSW Australia. We primarily select Australian produced essential oils where possible. Aromatherapy exhibit gardens allow accommodation guests (and visitors by appointment only) to see and enjoy the plants used in our products.
Packaging - We have selected recyclable glass containers and natural packaging materials where practical. You may choose to reuse them. All packaging we receive for bulk supplied materials is reused or recycled.
Conservation - We plant one tree on our Kangaroo Valley property for every purchase to help regenerate the land and provide habitat for the local Australian native wildlife. Crystal Creek Meadows is an official partner of the UN International Year of Forests 2011. Customers ordering our Aromatherapy Hampers have the option to make a donation to support Friends of the Brush-tailed Rock-wallaby.


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Celebrate St Patrick's Day tomorrow with this whole grain twist on cabbage rolls. Our Label Content Manager, Michelle (who also writes the beautiful blog Je Mange la Ville) came up with these delectable cabbage rolls using lamb, whole grain Kamut® berries and Savoy cabbage. Serve this with a side of soda bread for a hearty, Irish meal. If you can't find Kamut® berries locally, you can substitute wheat berries.
Lamb and Kamut® Cabbage Rolls with Tomato Sauce
Serves 6-8
- 1 small head Savoy Cabbage, separated into leaves
- 4 Tbsp Olive Oil
- 2 medium Onions, chopped
- 6 Garlic Cloves, minced
- 1 medium Carrot, diced
- 1 Green Bell Pepper, diced
- 1/4 tsp ground Cinnamon
- pinch ground All Spice
- 1/2 tsp Kosher Salt
- 1/4 tsp freshly ground Pepper
- 3/4 pound ground Lamb
- 1/2 cup Kamut® Berries
- Salt and freshly ground Black Pepper
- One 28-ounce can crushed Tomatoes
- 1/2 tsp dried Oregano
- 1/4 tsp (or to taste) Crushed Red Pepper Flakes
- 1 cup crumbled Feta Cheese
- Garnish: Cilantro or Parsley Leaves
The night before making, add Kamut® berries to a pot and add 3 cups water. Bring to a boil, turn off heat and let sit overnight or up to 12 hours. Drain and set aside.
Preheat oven to 375° F. Bring a large pot of salted water to a boil. Add the cabbage leaves to the boiling water a few at a time and cook for 30 seconds to one minute, or until pliable. Remove the leaves from the water and transfer to a colander; rinse with cold water. Gently shake to remove most of the excess water and set aside.
Put 2 tablespoons of the olive oil in a large pot oven over medium-high heat; when hot, add half the chopped onion and half of the minced garlic, along with the carrot and half the bell pepper, cinnamon and all spice. Cook until soft, about 5 minutes. Sprinkle with salt and pepper and transfer to a bowl. Add the ground lamb and drained Kamut® berries. Mix until just combined.
With the pan you just cooked the vegetables and spices in, add the remaining 2 tablespoons olive oil and turn the heat to medium-high. When the oil is hot, add the remaining onion, garlic and bell pepper. Cook until soft, 1 to 2 minutes. Add the tomatoes (and juice), oregano, and pepper flakes. Add salt and pepper to taste. Let cook over medium-low heat while you prepare the cabbage leaves.
Cut the cabbage leaves in half by running a sharp knife along each side of the stem, removing the stem. Lay a leaf on a work surface and put some of the lamb and Kamut® meat mixture in the middle of the leaf, and roll it up. Repeat with the remaining leaves and filling. Arrange all the leaves into a 9 x 13-inch baking pan and spread out as you need to fit.
Pour the tomato sauce over the rolls, spreading it evenly and making sure some gets down in between the rolls. Sprinkle the feta cheese on top. Cover with foil and bake 30 minutes. Remove foil and continue baking for 15-20 minutes. Serve garnished with fresh cilantro or parsley leaves.


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Pearl Vision VX825 22" Fusion Kit in Red Wine | Black Shell Hardware | Chrome Stands
This is a lovely intermediate kit for any drummer looking for the next step up in quality without breaking the bank. If you are moving up from a starter drum kit, the Vision series by Pearl will be an improvement in tone, build quality and hardware quality. This kit will hold it's own against others in the studio and at gigs.
Here's what Pearl say about The Vision VX825
The Pearl Vision VX drumkit features blended Birch Ply shells with 6/8 shell technology. Lower frequencies require greater energy to project equally to match the high frequencies produced by smaller drums. The combination of six-ply rack toms and eight-ply floor toms and bass drums deliver a dynamically balanced sound. VX comes with a Brushed Steel SensiTone snare drum and 700 Series Hardware.
Pearl Vision VX offers a sonically advanced recipe of strategically arranged plies of premium wood to maximize frequency response in every component. As with all Pearl drums each shell is formed from the legendary SST construction process that uses extreme heat, Precision cut scarf joints, the proprietary Acoustiglue and over 1000lbs of hydraulic pressure to create the ultimate acoustic air chamber.
Pearl Vision VX features Pearl's legendary SensiTone snare drums, that have been the choice of discerning drummers for years. As the name implies these drums provide extreme sensitivity combined with amazing tone and clarity due to their 5.5" steel shell that projects extreme volume with articulate response for dynamic power and cut.
Vision's 700 Series hardware provides the ultimate combination of rugged durability and innovative functionality. As with all of Pearl's Advanced Hardware, you get professional high strength dependability with sure grip over-sized rubber feet and out parallel Sure Struts that resist lateral twisting to prevent squeaks and instability.
Included in this kit
- 22 X 18" Bass Drum
- 12 X 9" Hanging Tom
- 10 X 8" Hanging Tom
- 14 X 14" Floor Tom
- 14 X 5.5" Snare Drum
- TH88i Tom Arms X 2
- Pearl Hardware Pack 700
- Cymbals & throne not included


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To view volunteer opportunities and sign up to serve, please visit the OurCalling Thankgiving page.
This Thanksgiving, DTS is once again opening its facilities to host the annual meal for homeless men and women in the Dallas area put on by OurCalling.
OurCalling was founded in 2001 by DTS grad and adjunct professor Wayne Walker (MA/CM, 2007) to address the spiritual needs of the homeless which often get overshadowed by the obvious physical and mental needs. OurCalling focuses on evangelism and discipleship through meals, Bible studies, life skills classes and one-on-one mentoring.
This year's Thanksgiving dinner is expected to draw more than 800 men, women, and children without homes from around the Dallas-Fort Worth metroplex. The guests will be seated with host families in order to share a meal together. OurCalling will be distributing coats and blankets for the winter, serving a traditional Thanksgiving meal, hosting a time of worship and enjoying the televised football games throughout the afternoon on Thursday, November 28, 2013.
Reflecting on the 2012 event, Walker commented that the meal "not only provided a great opportunity for outreach, it also let the guests feel like a part of a family again." He added, "Many have not had a 'family meal' in years and it was an emotional day for everyone involved."
If you are interested in helping OurCalling with this event, donations of blankets, coats, and financial support are welcome, but more importantly, volunteers are needed to set up, serve, distribute resources, pray with and share the love of Christ with our homeless friends.
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zavk wrote:I find Ven. Analayo's arguments extremely cogent, fair, and balanced. Definitely my preferred interpretation of ekayano maggo
I agree - except for one small detail. In poetry the choice of expressions is often limited due to the metrics. Therefore an argument based on what is NOT said in a verse from the Dhammapada, would not be very convincing on its own. But all the other arguments Ven. Analayo puts forward, are good. So this is really just a quibble - but he would have made his point well enough (or even better) without mentioning the Dhammapada.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Sunday, September 24, 2017
Mouth Diseases
Bigger Tastebuds
My son accidentally drank hot water from our water dispenser when he was 2yrs. old. Now he is 11 yrs. old and there`s a small portion of his tastebuds near the front part of his tongue that looks bigger than the other tastebuds and whitish in color. He says they don`t hurt but I`m worried about it. Is this an effect of the burning incident? Our dentist told me to bring him to an EENT doctor, is this the right doctor to see?
Your dentist is correct in referring your son to an ENT physician to evaluate the tongue lesion, if only for a second opinion and to have another set of eyes evaluate the problem.
Without seeing your son and based upon the history you have provided, the scalding that occurred on the tongue may have resulted in a significant trauma to the mucosa that has resolved with increased fibrosis at the injury site. Note that this is only a speculation - it may be nothing more than an anatomic variant (variation of normal!). Again, without actually examining this I can only guess about what you are describing.
Also what you are probably describing may be taste buds, but more than likely is the filliform and possibly fungiform papilla that occur on the dorsum of the tongue, and the whitish coloring is keratin and the result of the papilla becoming elongated.
Again, I can only assume what you are describing, and I am providing you with possible explanations in order for you not to worry.
Finally, the ENT physician may want to definitively diagnose the problem, in which case he/she may want to get a sample of the lesion and have it microscopically evaluated by a pathologist, to determine what is going on. This is a normal procedure to rule out possible pathologic problems.
I hope this helps.
Richard J Jurevic, DDS, PhD
Formerly, Assistant Professor of Biological Sciences
School of Dental Medicine
Case Western Reserve University


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Machu Picchu
9 Jan 2013 at 18:25
Cool! Tami found a llama. Llamas are iconic animals in Peru, and they love to eat grass.
With Tami
Press | FAQ | Terms of Agreement | Privacy Policy | Copyright © 2011 Flatter World Inc.
FLAT STANLEY® is a trademark of the Trust u/w/o Richard C. Brown f/b/o Duncan Brown. Used with permission. All rights reserved


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All parents hope their children will live happily ever after, but this carriage crib is straight out of a fairytale. Equipped with a rear changing table, this pricey piece of furniture, sold at Petit Tresor for $14,899, is a place for lil princes and princesses to rest their heads.
Is this lux cradle a sweet dream or a nightmare?


text: Ghosts of Legion Field haunt Herd By Doug Smock November 11, 2012 Story Share BEFORE MARSHALL'S game Saturday against the University of Alabama at Birmingham, I was told Mark Snyder paid a visit to the Thundering Herd's team hotel.Makes sense. The former MU head coach is defensive coordinator at Texas A&M, which played at Alabama. When your team travels to Alabama, it likely will stay in Birmingham, roughly 55 miles northeast of Tuscaloosa. The Aggies' hotel was close to the Herd's hotel.When I tweeted that little tidbit, the jokes flew. Among them was the almost-mandatory blast about running a reverse from the 6-yard line.To refresh your memory, that was the play Snyder's offensive coordinator, John Shannon, had scripted for the Herd's first scrimmage down in a 2008 debacle. Darius Passmore was tripped about 6 yards deep in the end zone for a safety, a wretched start in a game the Herd lost 23-21.The venue? Legion Field, with UAB the host team.Talk about your eerie parallels. That had been the last time Snyder coached in the state of Alabama, and he did much better this time as his Aggies downed No. 1 Alabama, in a game played at roughly the same time as Marshall-UAB.The 2008 mess at UAB was one of Snyder's most inexcusable losses, and it was the first time I began to consider the Snyder era a lost cause. And now, I am starting to wonder about the Doc Holliday regime.Coaches tend to get blamed for every loss and even for close wins, but the Herd clearly got outwitted by UAB's coaches in this one.As reported in the Birmingham News, UAB coach Garrick McGee detailed how his team switched to a three-man front and dropped eight defenders into pass coverage, a look the Blazers had used sparingly in the previous nine games. Accordingly, Marshall and quarterback Rakeem Cato favored the run in the first half, with 28 attempts vs. 13 passes. When you consider the three sacks to be pass calls and throw out a kneel-down at the end of the half, the ratio is 24-16. That would have been nice if the Herd could have managed more than 2.43 yards per carry. And that has me muttering: Were the Blazers really dropping eight on every play?"Every play, from the first play to the last play," Cato said. "I never saw it before, ever."Fine, but not all Blazers stayed back long on every play. Of Cato's three sacks, one came from a cornerback and another from "Jack" linebacker Chris Rabb. The other "Jack," Greg Irvin had 21/2 tackles for loss.And middle linebacker Marvin Burdette had 17 tackles, and they didn't come from tackling somebody from behind. The school's newest all-time leading tackler was involved in one tackle for loss, and half his 14 stops through three quarters held the Herd to 3 or fewer yards. Of the Herd's first nine possessions, eight were futile and the other was a 2-yard touchdown drive. With 5:23 left in the third quarter, necessity forced the Herd into throwing and, hey, it worked. In those final 20 minutes, Cato was 13 of 18 for 156 yards. Cato finished with a 214 passing yards and the team gained 337 total, both season lows. This coming against a defense that, even with Burdette, has been shredded several times."It took us longer than it should have to adjust to that," said tackle Jordan Jeffries. "They did drop eight, and then we run the ball and rushing three turned into blocking six or seven or eight. We came in and made adjustments at halftime, but we just dug ourselves too big a hole [31-7] to come out of."If an offense needs a half and then some to adjust to defensive wrinkles, I'm guessing the coaches lost the chess match, much like Snyder's staff lost it in the 2008 UAB game.But that is tolerable compared to the Herd's general flatness. Late in the first half, I thought I saw about five dozen white-clad zombies on the far sideline. The body language spoke volumes.To which I ask: How does that happen?This wasn't a throwaway game. A win would have put the Herd in good position to take another game and land in a bowl. But now the Herd must win twice, including the season finale at East Carolina, Conference USA's third-best team. The Herd rallied from 4-6 last season, but I don't think Marshall fans are clinging to optimism on that note. The fan base was deflated by the 54-17 loss Oct. 27 against Central Florida, and surely isn't happier now.Here's the little bit of good news I can offer: The Herd (4-6, 3-3) faces Houston (4-6, 3-3) at noon Saturday at Joan C. Edwards Stadium, and these are not the same Cougars that flogged MU 63-28 a year ago. On Saturday, they were hammered 41-7 by visiting Tulsa, getting outgained 505-262.With Case Keenum long gone, Houston leads the league with 31 turnovers, nine coming in a 72-42 loss at Southern Methodist. The Cougars have yielded 196 points in their last four games.Historically, teams from Texas are 0-for-8 in Huntington. Houston tumbled hard in 2008, losing 37-23 in a game that wasn't that close. Marshall led 37-9 after three quarters.When did that game fall on MU's schedule? Right after the loss to UAB, funny enough. Is that a good omen for this Herd team?After the most inexcusable loss in his 35-game tenure, Holliday needs a good omen.Reach Doug Smock at 304-348-5130, by email at firstname.lastname@example.com or follow him at twitter.com/dougsmock. Story Share Story Share Trending Now 1 Facebook founder visits Cabin Creek Health Systems 2 Teen pleads guilty to voluntary manslaughter in Oakes Field shooting 3 Reunions: Sept. 26, 2017 4 Safety shutoff disabled prior to June coal-mining death, report says 5 Huggins, WVU tap South Florida hoops talent What about GW's defense? Previous Story Jordon rules: Players need to shake hands after games Next Story


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Leipzig, Germany, March 4 – The ISC'13 HPC in Asia Session is inviting researchers and engineers to submit research posters to be displayed during the session. The session, which is now incorporated into the main conference program, is to be held on Monday, June 17.
The five-hour session aims to share information on the latest HPC systems and applications from leading supercomputing countries in Asia – China, India, Japan, Korea, Singapore and Taiwan – as well as presenting related HPC activities and research in those nations.
The first two events in this series were held under the name "HPC in Asia Workshop" in conjunction with previous two ISC conferences. The success of those workshops led organizers to provide a permanent platform for HPC initiatives in Asia and expand the scope to include research posters.
The 2013 poster presentations include the following topic categories, but are not limited to them:
• Applications: any fields of science and engineering computing led by Asian research groups with local HPC resources
• Systems: research on system hardware/architecture/software led by Asian research groups
• Performance: system performance analysis related to Asian HPC systems
Review of Poster Submission
All submitted posters will be reviewed by the workshop steering committee based on an extended abstract (two-page A4 format), including figures, tables and references. Posters will be judged based on scientific value as well as the subject's significance to state-of-the-art research in Asian countries. Please submit your poster as PDF document to firstname.lastname@example.com. In your accompanying e-mail, please indicate the name and address of the corresponding author and the topic area.
Poster Presentation
All accepted posters will be displayed at the HPC in Asia Session and along with ISC'13 posters during the conference. The final posters may not exceed A0 portrait paper size (841mm x 1189mm / 33.1" x 46.8").
Submitters will be required to attend ISC or send a representative to present the poster. The extended abstract and poster materials will be included in the ISC'13 website as a collection of workshop materials.
Important dates
• Deadline for abstract: Friday, May 4, 2013
• Acceptance notification: Friday, May 17, 2013
• HPC in Asia Session: Monday, June 17, 2013
The session will conclude with an interesting panel discussion titled "How Can Asians Conduct Excellent HPC Research with Limited Resources?" Participation will include the six supporting member countries.
The full conference program will be available online on March 15, coinciding with the opening of ISC'13 registration. In the meantime, visit www.isc13.org to find about the ISC'13 topics, the exhibition and the various opportunities available for attendees to participate in this year's event.
Look into your travel and stay early
Leipzig is a popular destination in June, as the city is filled with classical music lovers who come from all over the world for the Bach Festival. Therefore we advise attendees to look into their travel plans as early as possible.
If you fly with any of the Star Alliance members, you are eligible for a discount of up to 20 percent for yourself and your companion. Full information is available here. Our hotel booking partner, KIT, offers accommodations in selected price categories. To find a place to stay, visit https://www2.kit.de/kithbs/public/scripts/hotels.php?hcid=-1
About ISC'13
Every year ISC attracts a larger crowd than the previous year, drawing those interested in gaining new insights into their areas of interests in HPC, be it various HPC applications, engineering, advancement of HPC and other related technologies, or simply to meet new people to collaborate and do business.
ISC is the world's oldest and the most significant high-performance computing conference and exhibition in Europe for the global HPC community. It offers an exceptional five-day technical program with a wide range of expert speakers and exhibits from leading research centers and vendors. A number of events complement the conference and industry tracks including Tutorials, Workshops, Panels, TOP500 Announcement, Research Paper Sessions, Birds of a Feather (BoF) Sessions, Research Poster Session, Student Cluster Competition, Exhibitor Forums, and the popular Vendor Showdown (in a new format featuring leaders from industry), and as well as a number of satellite events organized by our partners and sponsors in conjunction with ISC'13. The conference has experienced tremendous growth over the last few years, with an estimated 2,500 participants from around the world expected to convene in Leipzig, June 16 – 20.
ISC'13 is open to IT-decision makers, scientists, researchers, members of the HPC global community and other interested parties. The ISC exhibition allows analysts, decision-makers from the automotive, defense, aeronautical, gas & oil, banking and other industries; solution providers, data storage suppliers, distributors, hardware and software manufacturers, the media, scientists and academicians to see and learn firsthand about new products, applications and technological advances in the supercomputing industry today.


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Pfeiffer Vacuum has introduced the dry pumps A 100 L for flexible integration in semiconductor production facilities. These dry multistage roots pumps are suitable for clean applications. Despite their compact dimensions, the pumps provide high pumping speeds and short pump down times.
The further development, the A 100 L ES, cuts energy consumption by up to 50%. Its pumping speed is significantly higher in the low pressure range. Additional benefits include a lower final pressure and reduced noise level. In addition to energy savings, the final pressure of the A 100 L ES is reduced to 7x10-4 mbar (hPa). This opens up new potential applications requiring an enhanced pumping capacity combined with low pressure. The noise level is also reduced from 58 dB (A) to 55 dB (A).
Pfeiffer Vacuum, www.pfeiffer-vacuum.com


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16 U.S. Code § 824j–1 - Open access by unregulated transmitting utilities
prev | next
(a) Definition of unregulated transmitting utility
In this section, the term "unregulated transmitting utility" means an entity that—
(1) owns or operates facilities used for the transmission of electric energy in interstate commerce; and
(b) Transmission operation services
Subject to section 824k (h) of this title, the Commission may, by rule or order, require an unregulated transmitting utility to provide transmission services—
(1) at rates that are comparable to those that the unregulated transmitting utility charges itself; and
(c) Exemption
The Commission shall exempt from any rule or order under this section any unregulated transmitting utility that—
(2) does not own or operate any transmission facilities that are necessary for operating an interconnected transmission system (or any portion of the system); or
(d) Local distribution facilities
The requirements of subsection (b) of this section shall not apply to facilities used in local distribution.
(e) Exemption termination
If the Commission, after an evidentiary hearing held on a complaint and after giving consideration to reliability standards established under section 824o of this title, finds on the basis of a preponderance of the evidence that any exemption granted pursuant to subsection (c) of this section unreasonably impairs the continued reliability of an interconnected transmission system, the Commission shall revoke the exemption granted to the transmitting utility.
(f) Application to unregulated transmitting utilities
The rate changing procedures applicable to public utilities under subsections (c) and (d) ofsection 824d of this title are applicable to unregulated transmitting utilities for purposes of this section.
(g) Remand
In exercising authority under subsection (b)(1) of this section, the Commission may remand transmission rates to an unregulated transmitting utility for review and revision if necessary to meet the requirements of subsection (b) of this section.
(h) Other requests
The provision of transmission services under subsection (b) of this section does not preclude a request for transmission services under section 824j of this title.
(i) Limitation
(j) Transfer of control of transmitting facilities
Nothing in this section authorizes the Commission to require an unregulated transmitting utility to transfer control or operational control of its transmitting facilities to a Transmission Organization that is designated to provide nondiscriminatory transmission access.
Source(June 10, 1920, ch. 285, pt. II, § 211A, as added Pub. L. 109–58, title XII, § 1231,Aug. 8, 2005, 119 Stat. 955.)
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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The Galician side come up against the Atletico Madrid on Friday, and their coach has warned his troops that they will have to keep the "world's best No.9" quiet
Celta Vigo boss Paco Herrera has claimed that Real Madrid striker Karim Benzema does not have the same striking instinct as his Atletico counterpart Radamel Falcao.
The Colombian has been in fine form this season, and has been linked with a host of clubs across Europe, inlcuding the Spanish champions.
The Galicians go up against Diego Simeone's side on Friday, and Herrera is in no doubt as to who his side will have to keep quiet.
"Falcao is now the world's best pure No.9. Another striker who I also love is Benzema, although he's perhaps not an 'old-fashioned' striker," he told reporters at a press conference.
"He does not have a finisher's brain like Falcao does. We'll have to do very well to defend against him because in the area he is a phenomenon."
Falcao has enjoyed an excellent start to his Liga campaign, scoring 17 goals in 15 games.


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Harper slides down to sixth in Nationals' order
WASHINGTON -- A day after saying that outfielder Bryce Harper would hit near the top of the batting order against right-handed pitchers, Nationals manager Matt Williams decided to place Harper sixth in the order against Cubs righty Carlos Villanueva on Saturday afternoon.
The reason for the change of heart is that Harper is 3-for-15 (.200) in four games since being activated from the disabled list on Monday. Harper missed two months of action because of torn ligaments in his left thumb.
"Bryce is a little tick off [with his swing]," Williams said. "We certainly want to get him going. He needs at-bats. Yesterday, I thought we would give him an opportunity to potentially get some good fastballs to hit if Denard [Span] got on. [Harper] is a little jumpy still. He continues to work on it. He'll be fine. He'll get it. It will come quickly."
With Harper hitting sixth, second baseman Anthony Rendon was moved back to the second spot in the order. Entering Saturday's action, Rendon was hitting .290 with nine homers and 34 RBIs in 59 games hitting second this season.
Bill Ladson is a reporter for MLB.com and writes an MLBlog, All Nats All the Time. He also can be found on Twitter @WashingNats. This story was not subject to the approval of Major League Baseball or its clubs.


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Corn futures couldn't sustain their Monday night bounce. The lack of change in corn ratings on Monday's USDA Crop Progress report seemed to spark a technical rebound last night. However, bulls couldn't sustain the rise, which probably reflected great growing conditions across the Corn Belt. Tweets from the Doane crop tour may be encouraging bears. September corn settled 3.75 cents lower at $3.6025/bushel Tuesday, while December dipped 3.75 cents to $3.6825.
Export news supported nearby soy futures, but weather depressed the deferreds. Soybeans and products also rallied Monday night. Those gains were reinforced when the USDA reported sizeable meal and oil sales this morning. But new-crop prices slowly moved lower in apparent response to gorgeous Corn Belt weather and prospects of a massive fall harvest. August soybean futures ended Tuesday 8.25 cents higher, at $11.84/bushel, while November futures fell 13.75 to $10.5775. August soyoil dropped 0.21 cents lower to 35.93 cents/pound, whereas August soymeal rose $1.1 to $381.8/ton.
The wheat markets followed corn lower. Monday's Crop Progress report held few surprises. Otherwise, wheat news was rather sparse Tuesday, which seemingly opened the door to outside influences, particularly from the corn market. That is, diving corn costs undercut wheat usage as feed. September CBOT wheat slumped 5.5 cents to $5.245/bushel as Tuesday's trading ended, while September KC wheat sank 6.75 cents to $6.2125/bushel, and September MWE wheat sagged 4.50 cents to $6.1875.
Wholesale strength continued boosted CME cattle. The cattle and beef complex once again confounded widespread expectations of seasonal weakness. Monday's strong wholesale gain and today's big follow-through seemingly persuaded traders that cash cattle prices will remain firm and possibly rise this week. August live cattle soared 3.00 cents to 155.95 cents/pound at their Tuesday settlement, while December leapt 2.57 cents to 157.92. Meanwhile, August and October feeders spiked the 3.0-cent daily limit to 216.02 and 216.90 cents/pound, respectively.
CME hogs seemed to bounce from technical support Tuesday. The cash hog markets declined Monday, while pork cutouts dove; those data almost surely sparked the follow-through selling seen last night. However, futures had reached sharp discounts to the CME index, which seemingly enabled them to find support and follow cattle futures higher. August hog futures surged 2.47 cents to 127.57 cents/pound late Tuesday afternoon, while December added 0.60 cents to 104.50.


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One of the main draws to the hybrid cloud is creating an app that might be small today but could scale to be huge tomorrow. However, scalability is not something that happens right out of the box; it has to be built into your app and infrastructure.
In order to take advantage of the scalability of the cloud, you should build your application in a modular fashion. This means splitting your site into three tiers: web, application and database. Achieving this level of modularity allow a business to scale out the tier that needs more resources as traffic dictates it.
The Rackspace Cloud Launch Team is here to help advise you on how to prepare your app to be highly scalable. In this video installment of the Insider's Look, you can see the level of expertise my team brings to the table to help you with your app's architecture. Furthermore, for those customers who are not experienced in hosting technologies, we offer a managed service level that offers more hands-on assistance with system administration.
If you have any questions, be sure to give us a call at Rackspace and ask to speak to a Cloud Launch Manager.
Take an insider's look at how the Cloud Launch team approached the architecture of an Ecommerce site in the previous video and blog post by Joseph Palumbo.


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A group of gamers known as "Cloudboat Armada" put a team of over 20 gamers to work in shifts around the clock, playing for 89 hours straight and raising $10,380 for the Child's Play, a group which provides games and toys to children to make their stays more enjoyable in over 70 hospitals around the world.
The event was broadcast live online from the Dojo. Over 50 independent video game developers were lined up to come and be interviewed during the event every hour between 8 a.m. and 8 p.m. for several days. Organizer Elena Churilov said video game enthusiasts from all over the world tuned in to chat with the group and make requests for video games to play.
"IGG is an opportunity to share games and have fun, while at the same time having a real positive effect on the world," Churilov said.
"It's definitely a mutually beneficial situation," said Brendan Mauro, one of the game developers who was invited for an interview. On Friday afternoon, Oct. 18, he was able to publicize his San Francisco-based company's new game, Extrasolar, which allows players to drive a rover on a fictional planet where life is believed to exist, while uncovering the motives of "a private space agency with a shadowy past."
"We have a strong interest in science and space and we would love it if more people were interested," Mauro said of the game, which he says has many details based on NASA research. "This is our small part to assist in that."
Churilov started the event with Shamayel Daoud and Matthew Rasmussen (Rasmussen came up with the idea) three years ago, running the event inside a friend's home. Needless to say, the group says it is thrilled to have the Dojo's ultra-fast internet connection to allow for higher quality video streaming.
The event has plenty of publicity and interest because of the nature of the independent video game community. Independent game developers work alone or in small groups — some "wildly successful" financially and others just working as hobbyists — but almost always communicating with other developers or fans online.
The event has a wide reach. Because it continues around the clock, "We hit every time zone," Churilov said, so, for example, European gamers chat with the group in the middle of the night.
The marathon ended at 5:24 a.m. on Oct. 21. For more information, visit iggmarathon.com.


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The main winter annual broadleaf weeds in wheat in Kansas are the mustard species and henbit. These species germinate in the fall or early winter, overwinter, then bolt in the spring.
With a couple of exceptions, the winter annual broadleaf weeds can be controlled relatively easily with the array of herbicide options available for wheat. The exceptions are:
- ALS-resistant populations of bushy wallflower (treacle mustard) and flixweed (tansy mustard)
- Late applications
ALS-resistant populations of bushy wallflower and flixweed
Bushy wallflower (treacle mustard) and flixweed (tansy mustard) populations resistant to ALS-inhibiting herbicides (such as Finesse, Glean, Ally, Express, Affinity, Amber, Olympus, PowerFlex or Beyond) have been confirmed in central Kansas in recent years. This class of herbicides has been around for many years and has historically provided excellent control of mustard species in general. A complete failure to control one of the mustard species with an ALS-inhibiting herbicide is probably a pretty good indication that an ALS-resistant population has developed.
ALS-resistant bushy wallflower was first confirmed in Marion county in 2005, and based on field reports, seems to be fairly common in Marion, Dickinson, and Saline counties, but also may be present elsewhere. It was highly resistant to all ALS-inhibiting herbicides evaluated.
ALS-resistant flixweed was first confirmed from Saline County in 2007. ALS-resistant flixweed still seems to be confined to that general area. Some ALS-inhibiting herbicides still had some activity on the resistant biotype, but history tells us that if we switched to another ALS-herbicide, it wouldn't be long until we had resistance to those products as well.
ALS-resistant mustard populations likely developed in continuous wheat fields where either Glean or Finesse was routinely applied in combination with a topdress fertilizer application and in the absence of a tank-mix partner such as 2,4-D or MCPA.
Fortunately, the ALS-resistant mustards can still be controlled with a timely application of 2,4-D, MCPA, or the new herbicide Huskie. These products can be tank-mixed with ALS herbicides or used as an alternative to ALS herbicides. MCPA and Huskie can be safely applied to wheat in the fall through spring after the wheat has 2 leaves. However, 2,4-D should not be applied until wheat is fully tillered, which generally does not occur until sometime in spring.
These herbicides are active primarily through foliar uptake and have limited soil activity, so ideally they should be applied to plants with viable foliage and when temperatures are 50 degrees or higher to achieve optimum performance. If applying MCPA or 2,4-D with topdress nitrogen fertilizer, the ester formulation needs to be used as amine formulations are not compatible with liquid N fertilizers.
Starane or dicamba products generally do not provide very good mustard control, so wouldn't be very good choices to help control ALS-resistant mustards.
Late applications
Many producers like to wait to apply broadleaf herbicides until winter or early spring, for a variety of reasons. This normally works well for control of mustard species, but is less effective for henbit control. Winter annual broadleaves do not generally cause much yield loss if left uncontrolled in the fall. However, these weeds should be sprayed in early spring when they are actively growing, but before they begin to bolt.
Producers who wait too long before making a herbicide application can run into a problem if weather conditions such as high winds or wet weather prevent timely application. If the herbicide application is delayed too long, weeds can become too large to control effectively and yield loss may occur.