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Phase III PEG-Intron in HIV-infected Patients (Study P00738)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|HIV Infections AIDS
|Drug: PEG-Intron
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
|Official Title:
|Phase 3 Study of PEG-Intron in Heavily Treatment-experienced, HIV-infected Patients
|Study Start Date:
|March 2002
|Study Completion Date:
|October 2003
|Primary Completion Date:
|October 2003 (Final data collection date for primary outcome measure)
This study will randomize 675 patients (225 in each of the 3 arms) to either: PEG-Intron 1mcg; 3mcg or Placebo, at 90 centers worldwide. Each center will enroll approximately 10 patients.
Study drug will be added to optimized background anti-retroviral therapy of patients whose HIV RNA is incompletely suppressed by their therapy (HIV RNA 400-50,000 copies/ML) after 2-6 months.
A single dose reduction of 50% will be allowed for toxicity. An Interim Analysis will be conducted when 50% of patients have completed 24 weeks of therapy. The study treatment phase will be 48 weeks with monthly visits for virologic virologic and safety monitoring. The primary endpoint is change in HIV RNA from baseline to week to assess efficacy. Durability of response will be assessed at 48 weeks.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV positive
- History of virologic failure on at least 2 antiretroviral regimens including exposure to at least one NRTI, one NNRTI and one PI
- HIV RNA >400-<50,000 copies/mL
- Laboratory parameters: platelet count (75,000u/L, hemoglobin >9gm/dl, absolute neutrophil count >1,000/uL, SGOT/SGPT<5xULN.
Exclusion Criteria:
- Current ribavirin therapy
- Subjects with a recent diagnosis or history of moderate or severe depression requiring ongoing psychiatric intervention
- Females of childbearing potential who are breastfeeding, who are pregnant, or not using adequate birth control measures
- Concomitant use of immunosuppressants or cytotoxic agents
- History of seizure disorder requiring use of anticonvulsants
No Contacts or Locations Provided
Study Data/Documents: CSR Synopsis
|Responsible Party:
|Merck Sharp & Dohme Corp.
|ClinicalTrials.gov Identifier:
|NCT00035360 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 2, 2002
|Last Updated:
|March 7, 2017
Keywords provided by Merck Sharp & Dohme Corp.:
treatment experienced
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Peginterferon alfa-2b
Antiviral Agents
Anti-Infective Agents
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


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Mail: Southern statues symbolize suppession
Mail: Thanks for helping Aiden
More opinion
Fall: Good time to spray musk thistle in rosette stage
Robertson and Delsing re-elected chair, vice chair of NWB
More Ag News
A 1928 statue honoring the original historic Ft. McPherson is getting a new look this year, thanks to the efforts of an Eagle Scout applicant and his contributors.
With that much done, Mull is arranging to anchor a new bench in concrete for people who want to rest a little and ponder our history.
The statue stands on East Ft. McPherson Road, about a half-mile northeast of Ft. McPherson National Cemetery. It marks the site of the original Ft. McPherson, established in 1866 and commonly known as Cottonwood Springs.
The statue is a Union soldier. It is well anchored and protected by an iron fence, but was overshadowed by a nearby cedar tree. Cars could hardly park on the shoulder of the road so motorists could take a good look at it.
The turnout has been lengthened to 85 feet, enough room to accomodate a tour bus.
The Central Nebraska Public Power and Irrigation District donated dirt to create the turnout, and the Lincoln County Department of Roads covered it in crushed concrete.
Western Engineering will donate concrete and new aggregate to put near the statute and Bloedorn Lumber will donate form lumber, Mull said.
Mull needs about $600 more to complete the project with a bench and fencing along the neighbors property line, plus signs and a couple ornamental trees.
An account is established at Equitable Bank in North Platte the Logan Mull Eagle Scout Project. The bank will match contributions up to $300, so a $50-$100 donation would be huge, he said.
When the project is complete, historic marker signs will stand along the road in each direction, advising motorists of the point of interest ahead, according to Mulls plans.
The statue is the same size as the Sioux Lookout that once overlooked the Platte Valley. It is a significant part of Lincoln County, Mulls father Jerry said, because Ft. McPherson protected pioneers, settlers, railroad crews and telegraph lines.
Whos to say what would have happened without them? he said. Whos to say what those veterans did for us?
The face of statue has been damaged by a shotgun blast, similar to the damage once done to the Sioux Lookout. The Sioux statue was restored in 2001 by artist Mary Tanner of Lincoln County and the Mulls hope the Ft. McPherson soldier might be reconstructed the same way. Otherwise, it is in good shape, Logan said.
Flatrock Publishing, Inc.
1300 E 4th St., Suite F
North Platte, NE 69101

subset: commoncrawl


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Pljeskavica (PLYESS-ka-vee-tsa) is a Bosnian sandwich of ground beef and lamb molded into a thin, oversized disc and cooked on a grill, then stuffed in a slightly stiff, mildly flavored bun. That method means it's compared to a burger almost every time it's mentioned in American press, even if the analogy isn't entirely apt. When you look at a pljeskavica's cross-section you can see that the meat takes on a bouncy, sausage-like texture more than one of a loosely packed burger. But enough nitpicking: the experience of eating one is much like eating a burger—that is, one of hapless, meaty joy.
You can find these record-sized wheels of beef at Balkan grill joints and restaurants around the city, from Ukus to Kafana to Bosna Express, but at Astoria's Djerdan, they go the extra mile.
$12 gets you their plain pljeskavica, which is lightly smoky and sweetened by a touch of onion (also, it's huge, definitely best to share), but for an extra $2 you can get the punjena version. It's the same wheel o' beef and the same bun, but the meat is folded in half and stuffed with chunks of thick-cut smoked meat and crumbles of especially tangy feta. They go a long way toward flavoring the mild patty, well worth their two buck surcharge.
The sandwich, stuffed or unstuffed, comes with pungent red pepper spread (ajvar, which with this burger analogy you could call the Balkan ketchup) and raw chopped onions. Add 'em both to the meat as well—they're good additions.
About the author: Max Falkowitz is the New York editor and ice cream maker in residence at Serious Eats. You can follow him on Twitter at @maxfalkowitz.


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Teaser image of Noble Team's Commander Carter...
Rumors have swirled in regards to ThreeA Toys taking on the 1:6 scale Halo license, but today's teaser image appears to confirm it. Shown on ThreeA's Facebook page, the above sneak peek shows off Commander Carter, the leader of Noble Team from 2010's Halo: Reach. Full details to be announced.
Discuss this on OneSixthWarriors.com.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, RedfordFilms.com, Toynk.com, PastGenerationToys.com, BriansToys.com, ToyWiz.com, SmallJoes.com, MonkeyDepot.com, and Urban-Collector.com.


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Adduci suffers setback with fractured pinkie
ARLINGTON -- With Prince Fielder and Mitch Moreland on the disabled list, the obvious replacement at first base was right fielder Jim Adduci, but now he's unavailable.
"He re-broke his finger when he dove at first base the other day," general manager Jon Daniels said of Adduci, who was on rehab assignment at Triple-A Round Rock and was just a few games away from his return from a fractured left pinkie finger.
Daniels said Adduci and the doctor were going to try to let it heal on its own for a few days, but that when the pain didn't alleviate, Adduci went back in to reassess the situation.
"It had not improved, so he went ahead and had two screws put in the finger to allow it to heal properly," Daniels said. "We've got approximately three weeks before he'll be back playing games."
Grace Raynor is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Barley Salad with Lemon and Mint
(Makes 4 servings, recipe adapted from Cooking Light.
1 cup pearl barley
2 1/4 cups water
1/4 tsp. salt (I used Real Salt, a local Utah product)
1 cup chopped mint (or less)
1 cup chopped tomatoes
1/4 cup chopped red onion
3 T capers, drained well
10 pitted Kalamata olives, chopped small
Dressing Ingredients:
2-3 T fresh lemon juice
(use the smaller amount if you don't love lemon as much as I do)
3 T extra virgin olive oil
1 tsp. grated lemon zest
1/2 tsp. Greek Seasoning (Penzeys recommended)
Combine dressing ingredients in small glass jar and shake well.
Penzeys Greek Seasoning contains salt, oregano, garlic, lemon zest, black pepper, and marjoram. Another brand of Greek Seasoning that I like the flavor of is Cavender's Greek Seasoning. However, the Cavender's brand does contain MSG, which some people are sensitive to.


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EAST RUTHERFORD, N.J. – Defense wins championships.
Russell Wilson and Percy Harvin do too.
The Seattle Seahawks' Legion of Boom frustrated Peyton Manning and the Denver Broncos while Wilson managed the game plan with aplomb in a dominating 43-8 Super Bowl XLVIII victory Sunday at MetLife Stadium.
"It's not too crazy to us, because we knew what we had in our locker room," Harvin said. "We knew how we prepared and we knew what we were capable of."
The Seahawks limited the Broncos to 306 yards and intercepted Manning (34-for-49 passing, 280 yards, lost fumble) two times, claiming the first Super Bowl victory in franchise history.
"Sea-HAWKS," chanted the rowdy Seattle fans, who have become known as the "12th Man."
Wilson, meanwhile, stayed within himself, avoiding turnovers. He completed 18 of 25 passes for 206 yards, ran for 26 yards and threw second-half touchdown passes to Jermaine Kearse and Doug Baldwin to set the final score.
"At the end of the season, you want to play your best football. And that's what we did tonight," Wilson said.


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34 35th St., Unit 26, Brooklyn, NY, 11232
Lycan Theorized
The work of Christian Jankowski is a performance, which engages often unsuspecting collaborators to innocently collude with him, making them 'co-authors' of the final result, who often (sometimes inadvertently) participate in the very conceptualisation of the work. The collaborative nature of Jankowski's practice is paramount, as each participant unwittingly contributes his or her own texture. With Jankowski, there is as much emphasis on the journey as the destination, and the risks and chances inherent in his collaborations ultimately give surprising shape to the final works. The product of a generation that grew up with the ubiquity of film and television, its inherently populist influence is evident throughout Jankowski's work.
Christian Jankowski lives and works in Berlin.
Research: Production Lab
Project Type: Video
Tags: Film, horror, video
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YORBA LINDA – Eight buses filled with American POWs from the Vietnam War and their families were given a heroes' welcome Thursday afternoon as they arrived at the Nixon Presidential Library & Museum for a three-day reunion to mark the 40th anniversary of their homecoming.
"I know from a young age my family talked about the heroism, bravery and courage you had as POWs," said Christopher Nixon Cox, Nixon's grandson, in welcoming the crowd. "We will always measure heroism, bravery and courage by what you did in your time in Hanoi."
About 185 POWs came to the reunion that started with the greeting in front of the library. Before arriving at the library, they had driven down Yorba Linda Boulevard in a motorcade fronted by motorcyclists with the Patriot Guard Riders, a truck from the Fullerton Fire Department, one from the Brea Fire Department and an Orange County Sheriff's Department patrol car. Members of the public dotted the three-mile stretch from the 57 Freeway to the library to show their support.
Martha Tripp, a teacher at Brookhaven Elementary School, was with a group of students to cheer on the POWs as the buses drove down the boulevard. Her uncle, Fredrig Flom, a former captain, was shot down in 1966 and held captive for more than six years. He was participating in the reunion.
"I just want to be able to honor my uncle and all of the POWs," Tripp said. "These POWs, they're proud people who work hard."
Lee Ellis, who was a colonel in the Air Force, said he's felt very supported by the public as a POW of the Vietnam War at events and reunions such as Thursday's.
Ellis recalled his five and a half years in the prison, which Americans have sarcastically dubbed the Hanoi Hilton. He was a fighter pilot whose plane was shot down while he was doing armed reconnaissance. He was thrown into to six-and-a-half-by-seven-foot cell with three other prisoners.
To pass the time, he did mental activities. He learned calculus, French and Spanish. And one time, for two months, he pretended he had a farm, harkening back to his childhood on a Georgian farm.
"I started out with 40 acres, and I ended up with a whole county," he said of his success at mental farming.
Jim Mulligan, a former Navy captain, had already served in World War II and the Korean War by the time he made it onto the U.S.S. Enterprise during Vietnam.
His A-4 Skyhawk was shot down. He was knocked unconscious when he ejected, woke up in a rice paddy and was captured. He was thrown into solitary confinement for three and a half years after he was captured. It was like living a closet, he recalled. He and others dubbed the cell block Alcatraz.
Seven years later, he was finally released along with the other POWs in 1973.
"I went home to my wife and six sons," Mulligan said. "My wife had it tougher than I did."
Contact the writer: 714-704-3771 or email@example.com


text: EYECARE: Managed Care Davis Vision Names Burns President By Staff Monday, August 13, 2012 12:00 AM Celina BurnsSAN ANTONIO, Texas—Managed vision care company, Davis Vision, Inc. has named Celina Burns president. She began her new role Aug. 6. Burns brings more than 25 years of experience to her new position, with experience working for health insurers and health and welfare professional service firms, including Humana, Prudential Financial and Aetna. She joins Davis Vision from Buck Consultants, a Xerox Company based in Dallas, where she was a market leader and principal, responsible for overall development and implementation of strategic and operating plans and market management across all consulting practices, including health and productivity, retirement, investments and communications. Burns is a graduate of Texas State University with a bachelor's degree in allied health sciences. She is active with the American Heart Association, Health Industry Council, Dallas Fort Worth Business Group on Health and the North Dallas Business Chamber. She will be relocating with her family from Dallas to San Antonio.


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Gray fiberglass poles
Roller tip and tie-up cleat on whip
Plug and socket poles on 12', 14', 16' whips
Aluminum tensioner
Aluminum base with cleat and ring
Dockmate Mooring Whips are an excellent way to protect your boat or watercraft from damage caused by wind or high wake. These whips provide a "safety zone" between dock and boat with a unique "spring action" that keeps your boat away from the dock. The large diameter solid fiberglass rods are wrapped with cross-wound layers of fiber for superior strength and flexibility. The durable solid cast-aluminum base has a molded-in cleat and ring to easily fasten your lines. A functional roller tip on the whip in addition to a unique tensioner allow easy one-hand operation. Deluxe 12', 14', and 16' Whips offer a "plug and play" design for quick and easy separation of the two whip halves for storage. All Dockmate Mooring Whips come as a pair with all necessary lines and hardware to complete installation. Note that some docking conditions may be too rough for this type of system. 3-year warranty.


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Organic Market Gardening
Root Cellaring$16.95• A great how-to! • Learn how to keep your potatoes Learn More
Four-Season Harvest$24.95
Out of stockby Eliot Coleman Coleman shows the home gardener how to escape the confines of the growing season in chapters on compost, planning and preparing the outdoor garden, planting and cultivating, cold frames, tunnel greenhouses, root cellars and growing winter greens indoors. Revised Edition, 234 pages. Softcover. Learn More
Gardener's A-Z Guide for Growing Organic Food$22.95• Organic • The best gardening book out there! • Gardener must-have! Learn More
Return to Resistance$21.00
Out of stockBreeding Crops to Reduce Pesticide Dependence. Robinson analyzes crop breeding's successes and shortcomings and explains how groups of farmers can work together to brred crops with durable resistance. Learn More
The Beginners Guide to Growing Heirloom Vegetables$19.95Are heirloom vegetables more difficult to grow than conventional hybrids? The Beginner's Guide to Growing Heirloom Vegetables debunks this myth by highlighting the 100 heirloom vegetables that are the easiest to grow and the tastiest to eat. Learn More
Vertical Vegetables and Fruit$16.95At last, an innovative solution for urbanites, apartment dwellers, and anyone who wants to grow food in small spaces — grow up! Vertical Vegetables & Fruit shows how easy and fun small-footprint food gardening can be. Low maintenance and big harvests are just two of the benefits of using teepees, trellises, cages, hanging baskets, wall pockets, stacking pots, and multilevel raised beds to grow vegetables and fruit. Learn More


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Who inspired you to join this profession?
As a child, I always liked working with my hands. A family friend was a contractor and I always helped him out. Growing up, I wanted to be in medicine. Putting two and two together, dentistry turned out to a field that met both my needs. Also, my brother-in-law is an oral surgeon, so that helped guide me into this profession.
What's your education?
I attended Diablo Valley College for two years and transferred to San Francisco State University, where I majored in biology. I applied to University of the Pacific (UOP) because they offered an accelerated program – three years instead of four – and it's more of a clinical school rather than academic, which gave me more real-world experience. I did a one-year internship at Highland General Hospital in Oakland and then my four-year residency there, too. I have operated a private practice since graduating in 2004.
What are the duties of an oral and maxillofacial surgeon?
Oral refers to the mouth, and maxillofacial refers to the jaws and the face. It's a fairly broad field. We see clients for wisdom teeth extractions, which accounts for the majority of our patients; dental implants, which is our second most popular procedure; biopsies; problems with temporomandibular joints (TMJ); and trauma, such as when an individual suffers a car accident or an injury during an altercation. There is a branch of the field that does cosmetic surgery, but it's not common practice with the typical oral and maxillofacial surgeon.
What's your schedule look like?
My practice is a full-scope oral and maxillofacial surgery practice with the exception of cosmetic surgeries. I'm also part of the on-call trauma team at John Muir Hospital; I'm called to work there four or five times a month. A lot of my time is centered on the surgical aspect of my work. We see patients over the course of 36 hours each week; we set aside the rest of the time each week to focus on administrative work. Still, a lot of the administrative duties are done after hours, which pushes my work week toward 60 or 70 hours. On average, I see about 20 to 25 patients a day, and that consists of consultations, follow-ups and surgeries.
Where can an oral surgeon find work?
Most oral surgeons have their own office and associate with a hospital part time because a lot of what we do does not need to be done in a hospital, such as dental implants and extractions. Kaiser employs oral surgeons, but those surgeons focus solely on hospital based surgeries.
Is oral and maxillofacial surgery a good profession to pursue?
It's a great industry to enter into because dentists, for the most part, are in demand. In larger metropolitan areas, they're competing for business. But, if you also take into consideration rural areas throughout the nation, there's actually a shortage of dentists. It's a great profession to be in because as our population gets older, they're going to need a lot more work done.
What significant advancements have been made in dentistry?
Fifteen to 20 years ago, bridges were recommended to replace a tooth. Today, dental implants are recommended. They have an advantage over bridges in that implants don't touch or weaken the teeth adjacent to the site, which also negates the need for crowns on the nearby teeth, and implants preserve the bone connected to the replacement tooth and are longer-lasting. Dentistry has become more preventative, so problems like TMJ are not as common as one might think. Technology has played a big role, too. Instead of paper X-rays, we use digital photography and 3-D images to view teeth and jaws. This eliminates timely X-ray processing and significantly reduces the amount of radiation to which a patient is exposed.
Why do you love your work?
Most people are fearful just walking into a dentist's office, so I love my job because of the satisfaction I get treating a patient who arrives very nervous and leaves happy and at ease.
Any advice to future oral surgeons?
It's a tough road, but if you're consistent and hard working, you'll make it. Dental school is highly competitive, so persistence may pay off, too.
If you would like to be considered for a career profile or want to nominate someone, please e-mail Charlotte Cusack at email@example.com.


text: Into the Garden: Plant irises now to establish roots before winter By Sara Busse August 11, 2012 Story Share CHARLESTON, W.Va. -- In the spring, there's nothing like the tall, showy iris to add that punch of excitement to the garden.Irises come in many different shapes, sizes and colors. There are two main forms: bearded and beardless.Bearded irises are identified by thick, bushy "beards" on each of the lower petals of the blossoms. Originally, most bearded irises were native to Central and Southern Europe.Beardless irises are mostly native to Asia and include Spuria, Siberian, Japanese and Louisiana irises. They all bloom after the tall bearded irises, extending the iris bloom season even longer.According to the American Iris Society, now is the time to separate and to plant bearded irises for spring bloom. I found this information at www.irises.org:"This digging and separating is best done between one and two months after bloom season, usually in July or August. Soon after this the irises grow roots that help to hold the plant firmly during the winter in areas where freezing and thawing can result in heaving the rhizome out of the ground."Irises do best in sunny spots with well-drained soil. If the soil is clay, add very coarse sand and humus. Bone meal and a good garden fertilizer, low in nitrogen, are good for irises. The roots must be buried firmly to hold the plant in place, but the rhizome (the thick, fleshy root) should be near the surface. If you have several plants, plant them at least a foot and a half apart, "facing" the same way. The rhizomes will then increase in the same direction, without crowding each other too soon. According to the website, culture of the beardless irises differs somewhat from culture of the bearded irises. They should be transplanted in the fall or in early spring. The roots should never be allowed to dry out while they are out of the ground and they should be watered heavily after transplanting. They should be set slightly deeper than the tall bearded.Japanese iris should be planted in a distinct "depression" in heavy soil to assist in supplying moisture to the plant. Siberians and the Pacific Coast natives can tolerate light shade but the Spurias, Japanese and Louisianas demand full sun.Louisianas and Japanese require moist conditions during the summer months. All, except Louisianas, should be planted in a permanent spot where they can remain for many years as they resent being disturbed. Louisianas tend to "creep" and therefore, should be tended to every few years. All are heavy feeders and need to be fertilized regularly.Here's some good information from About.com on dividing irises: "You can help cut down on the incidence of soft rot and borer damage through regular division of the iris rhizomes every two to three years. This will also keep bearded iris performing and blooming at its best. If left undivided, the flowering will decrease and the rhizome will be subject to more pests and damage."You can divide bearded iris anytime after flowering through August. Using a pitchfork, carefully dig around the bearded iris plant, starting about a foot away from the outermost edge. Try not to pierce the rhizome with the fork. Work the fork around the bearded iris plant and gently lift the rhizomes out of the soil. Since bearded iris are grown at soil level, this is one of the easiest plants to lift."Recycling flowerpotsI recently put a note in this column stating that Lowe's accepts plastic flowerpots for recycling. I looked into this issue at the request of a reader. I called the Lowe's locations in the Shops at Trace Fork and in Kanawha City. The managers assured me that they take the pots for recycling. I was very specific with each of them about the matter.This week, I received another postcard from the reader who initially asked about recycling pots:"I made a trip to Lowe's with my six-packs and plastic pots. Unfortunately was told they do not accept these items."Did you confirm the tip from your reader before printing it?"Yes, I did.I am sorry you were inconvenienced, but I asked managers at both stores, and that's the best I can do. Reach Sara Busse at email@example.com or 304-348-1249. Story Share Story Share Trending Now 1 Facebook founder visits Charleston restaurant 2 Gazette editorial: Capito has second chance to do the right thing 3 Rod Run and Doo Wop brings classic cars, music to Boulevard for 12th year 4 Parole hearing set for Putnam man who claims wrongful sex assault conviction 5 Yeager Airport, Air Guard to celebrate 70th anniversary with air show Smell the Coffee: Almost heaven down by the riverside Previous Story Live Life Fully: What happens when you get a zero on the dismount? Next Story


text:
Great Cigars I Have Smoked: A Lesson in Inconsistency
Posted: Apr 24, 2007 10:28am ET
One of my first lessons in how cigars can be incredibly inconsistent came during the first few months after we had launched Cigar Aficionado. At the time, our ratings system was causing a bit of a storm in the cigar industry. The manufacturers had never been subjected to independent scrutiny about the quality of their cigars, and, of course, never had to face a 100-point rating scale. We were confident of our methodology, but, OK, I'll admit it, a wee bit defensive about the process.
In our second issue, we rated double coronas, and gave the Cuban Hoyo de Monterrey, from the 1992 vintage, a classic rating of 99 points. It was, and is, one of the greatest Cuban cigars ever made. But we gave a Partagas Lusitania a mere 88 points, saying that while it was good, it had not lived up to its legendary reputation.
Within a month after the issue's publication, one of my favorite gentlemen in the cigar business, Max Guttmann from Mexico, showed up in our offices in New York. Max is an international businessman, and he owns the Casa del Habano franchise in Mexico. He is sophisticated and urbane, and has one of the greatest collections of cigars that I've ever seen. But at the time, I didn't know him that well. He walked into my office, and in so many words—kindly of course—said we didn't know what we were doing. I went through the usual litany about the fact that tastings are subjective, and that in this case, we had all arrived at the same conclusion.
Max pulled out his leather cigar case, pulled apart the two sections, and drew out one of the darkest, oiliest, most luxurious looking cigars that I had ever laid eyes on. "This is a Lusitania," he said, continuing to extol its virtues as his favorite cigar, saying it was much, much better than most Hoyos.
I agreed to smoke it on the spot with him. In my memory, I can remember it being so oily that it felt like I had to hold on tight to keep it from slipping out of my fingers. It was firm, but not hard, and had that indescribable aroma when held under your nose that seems to come from somewhere between a barnyard and an earthy, mushroom patch.
I clipped and lit it, and I knew immediately that I was smoking one of the greatest cigars that I would smoke in my life. I found all those flavor characteristics that we'd already been taught were the hallmarks of a great Cuban cigar. Sweet cocoa bean. Leather. Spice. An incredibly complex smoke with a finish that never seemed to stop. I didn't want to put it out, and kept on smoking with Max until I felt I had to get back to work.
He sat there smiling.
I didn't score that cigar, but I would have given it at least 99 points, to match the Hoyo. In fact, it was probably a 100 point cigar. Unfortunately, I've never had another Lusitania quite as good as that, and certainly, in the dark days of the Cuban cigar industry during the late 1990s, there were many that didn't resemble anything that could be called great.
But that day is notable for two things. I did learn a lesson about how important it was to taste cigars blind, and judge them for what you smoke, not what you think it should smoke like. And, I smoked one of the greatest cigars of my life.
P.S. Over the next few months, I will writing a "Great Cigars I Have Smoked Series." There are about a dozen stories to be told. But this was one of the best, and one of the first.
Comments2 comment(s)
Jose Blanco April 25, 2007 7:39am ET
Gordon nice review and if memory serves me right that cigar at that time would have tabaco at least 3 to 4 years old and those were great.
Tanner K New Canaan, CT May 1, 2007 11:47pm ET
Great, great story, Mr. Mott. Those Lusi's are fantastic... very, very unique. I've only had one, so consistency isn't something I can comment on. It's definitely one of the best smokes around, and I'm glad you enjoyed yours!As far as judging cigars blindly, I wholeheartedly agree. I'm rarely objective when it comes to cigars, so I usually de-band them, and then smoke them later (after I re-band them numbered, of course!).
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text:
according to autowire
Lewis could be traded as management is reportedly set to make a series of moves if the Sonics don't prove to be a playoff contender in the next month, the Seattle Times reports.
The Sonics have to go 8-5 in their next 13 games to hit .500 by the end of the month, the management's minimum goal to avoid a shake-up. Lewis is trade bait because he has the option to void the final two years of his contract after the season and become an unrestricted free agent. Lewis says he wants to remain a Sonic, but won't negotiate an extension until after the season.
too bad we still don't have that draft pick for next year it's looking to be like it would have been nice to have as the season progresses. I don't know what it would take to get Lewis but Donnie Walsh has expressed interest in having him on the team in other articles on pacers.com and in the IndyStar. I'd like to have Ray Allen the most but I definately would be more than Happpy to get Rashard Lewis on the team...anybody have any thoughts?


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SAN DIEGO, June 21 /PRNewswire/ -- Angstrom Pharmaceuticals, Inc., a biopharmaceutical company focused on the treatment of cancer and eye disease, announced today the initiation of a Phase 2 clinical trial of its proprietary lead product, A6, for the prevention of clinical relapse in patients with ovarian cancer at Brooke Army Medical Center in Fort Sam Houston. The study will enroll 48-60 patients and is designed to assess the safety and efficacy of A6 in asymptomatic women in clinical remission who have an elevated CA-125 tumor marker level following successful first line treatment.
"We are very pleased to have Brooke Army Medical Center participating in the A6 trial," said Virgil Thompson, President and Chief Executive Officer of Angstrom. "Our pre-clinical data show that A6 prevents metastases and inhibits tumor growth in animal models. We also have encouraging responses in some patients with advanced gynecologic cancer in our Phase 1 trial. This Phase 2 trial is designed to demonstrate the potential of our drug to forestall progression of ovarian cancer in women at high risk."
According to the American Cancer Society over 25,000 American women are diagnosed with ovarian cancer and 16,000 die from the disease every year. Currently only 25% of ovarian cancer cases are detected at the localized stage. Therefore the majority of patients will have Stage III or IV disease at the time of diagnosis and are at a high risk for relapse and disease progression following successful first line treatment.
Angstrom Pharmaceuticals, Inc. (http://www.angstrominc.com/) is a privately held pharmaceutical company located in San Diego, CA. Angstrom's drug, A6, targets the urokinase plasminogen activator system, which has been implicated in cancer progression. Preclinical studies have shown that A6 inhibits cell migration and cell invasion and blocks the supply of blood to tumors. In Phase 1 studies, daily injections of A6 were shown to be safe and well tolerated.
For study information contact:
Brooke Army Medical Center
Clinical Coordinator: Elvia Guerrero MD 210-916-5298
CONTACT: Elvia Guerrero MD, Clinical Coordinator of Brooke Army MedicalCenter, +1-210-916-5298
Web site: http://www.angstrominc.com/


text:
Urbana Mayor Vetoes Convention & Visitors Bureau Funding
The decision by the mayor of Urbana to veto city funding for the Champaign County Convention and Visitors Bureau will only hurt the city in the long run, according to the group's president Jayne DeLuce.
Mayor Laurel Prussing said the agency has not been effective, and that the nearly $72,000 in the budget for the CVB could be used to help fill two police vacancies instead.
But DeLuce said cutting funding will limit the CVB's ability to promote events like the Illinois Marathon and state high school athletic tournaments, and facilities like hotels and convention spaces. She said she will attend an Urbana City Council committee meeting on July 11th to defend her agency's work.
"We're not looking back in five years and saying, 'Wow, how come we don't have that event here anymore? How come nothing new has happened anymore? Why are our tax revenues staying plateaued or not increasing?' And when you decrease local funding, that's what happens," DeLuce said.
But right now, Prussing said she does not believe the CVB's claim that it has generated 7.2% of hotel room nights in Urbana, for an economic impact of over $3.1 million, according to a formula used by the state Office of Tourism.
"I think most of the tourists that come to Urbana and Champaign come here because of the University of Illinois," Prussing said. "I don't think that the tourism bureau has much of an impact. They can't measure their impact. No business in Urbana has told me they have an impact on that business."
A statement from DeLuce said one Urbana businessman --- Adam Friederich of the Comfort Suites Hotel --- credits the Convention and Visitors Bureau for nearly 10% of their budget revenues so far this year.
But Prussing said the city needs the money budgeted for the CVB to help close a nearly $1 million budget gap --- one that may get wider, once a new police contract is settled through binding arbitration.
Prussing said the idea for cutting CVB funding to help address the budget shortfall came from Alderman Charlie Smyth.
Smyth said he brought up the proposal last month, to contrast it with proposed cuts to social service funding --- something he said is an easy target because the people served by such funding do not have the political voice of local business interests. But Smyth said he has not reached a final decision yet.


text:
New York Starbucks Corp. said on Thursday it would eliminate 600 jobs as it works to turn around stagnating U.S. coffee shops in the face of a weak economy. Chief executive Howard Schultz, who made the announcement in an e-mail to employees, is slated to share details of the company's strategy at a shareholder meeting on March 19.
Starbucks laid off 220 employees on Thursday. One-third of them worked in Seattle, spokeswoman Valerie O'Neil said. Those employees performed a variety of duties from finance to design and marketing.
The company has also eliminated an additional 380 open positions, O'Neil said. None of the cuts affect people working at Starbucks outlets, she said, adding that Starbucks has 170,000 employees.
Sales at established U.S. Starbucks outlets fell last quarter, and the company has already announced plans to expand overseas and close underperforming U.S. stores.
UBS Equity Research analyst David Palmer called the move a visible step to remove bureaucracy and cost.
"We expect earnings to ramp through the year as unit growth slows, innovation improves (and) dairy pressures abate," Palmer said in a client note.
McAdams Wright Ragen analyst Dan Geiman said the layoffs were expected.
"I don't think it's a surprise at this point," he said.


text:
The most amazing stat regarding Luck's start is that he's 3rd in the league (behind Brees & Eli) in yards per game yet he is 32nd in percentage of yards which occured after the catch. He's not throwing a simple 4 yard slant and having guys run 75 yards after the catch.
His receivers, other than Reggie Wayne, are not getting open. At all. He's having to throw guys open. And he's succeeding. Truly remarkable.


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Aquaholics Surf Shop
Whether you need a board and suit to catch that nice swell, or some body boards for the kids- Aquaholics has it all! Take a virtual tour here.
Aquaholics Surf Shop has grown up (well, just a little).
We moved our store in Kennebunk just down the road from our previous spot. We have more boards, bathing suits, trunks, skimboards and anything else you can think of.
Aquaholics now has a kiosk on Old Orchard Beach.
Beach & Surf Rentals in Maine
Aquaholics offers a wide range of equipment for varying surfing abilities. Highly recommended for children and beginners, soft boards offer numerous safety features, durability, and easy handling. For the more experienced surfer, plastic and fiberglass boards are offered. To keep everyone happy and entertained, body boards, beach chairs, and umbrellas are available to rent for the day.
Private Surfing Lessons
Some of the many original women surfers in Maine teach at Aquaholics, and we take great joy in providing lessons and clinics for all surfers, but as always, we especially enjoy helping women and young girls feel comfortable in the lineup. The guys out in the water are quite friendly and have always been helpful, so don't be shy! Come by yourself or bring a few adventurous children or friends along!
You can take a virtual tour of a lesson here.
Private lessons are 1½ hours long, board and wetsuit are included. The time slots are as follows:
Surf Lessons 7 days a week:
* 3:00 PM - 4:30 PM (except on Sundays)
The cost is $100 for a single, $150 for two students and $200 for three students. The max number of students per instructors for a "private lesson" is three. After three, we add another instructor and the prices are as follows:
Group Surfing Lessons
Be ready to have the most fun EVER!
Please arrive 15-20 minutes prior to your lesson/camp time to get fitted for a wetsuit, sign a waiver and pay.
Parents are always welcome to stay and watch or take pictures!
Meet our instructors here.
Some of the many original women surfers in Maine teach at Aquaholics, and we take great joy in providing lessons and clinics for all surfers, but as always, we especially enjoy helping women and young girls feel comfortable in the lineup.
Book your surf lesson today- Call 207.967.8650!
It is highly advisable to call ahead for booking to get a preferred slot.
To check the Southern Maine weather forecast or Kennebunk Beach surf report:
* New England Surf and Wave Sports
* WetSand - World Wide Waves
Adults can try surfing for FREE, equipment included, Tuesday mornings from the now until August, call for details.
Maine Surf Camps - Summer
In the summer Aquaholics offers surf camps in Kennebunk, Biddeford Pool (Fortunes Rocks) and Old Orchard Beach. The camps are geared for beginner to novice, children and adults. (More experienced surfers should consider a private lesson). We provide wetsuits, Sunsets soft surfboards and CPR certified FUN instructors (we're all a little loony). We're also fully insured and sanctioned by the Parks and Recreation departments of the respective towns.
The camps are run Monday, Wednesday and Friday.
The times are either 8:30 to 10:00 A.M. OR 5:30 to 7:00 P.M.
The cost is $160 per camper.
To register you can call:
Biddeford Parks & Rec. at 207-283-0841 • http://www.biddefordmaine.org
Kennebunk Parks & Rec. at 207-985-6890 ext 1335 • http://www.kennebunkmaine.org
Old Orchard Beach Parks & Rec. 207-934-0860 • http://www.myrecdept.com/me/old_orchard_beach
Call Aquaholics at 207-967-8650
LocationsNew England » Fortunes RocksNew England » Kennebunk BeachNew England » Old Orchard BeachNew England » Ogunquit RiverNew England » Short SandsNew England » Long SandsNew England » Higgins Beach
ServicesSurf Shop Shops supplying surf boards, wetsuits, clothing, leashes, wax, deck pads, fins, DVDs and anything you might need to go surfing. Surfboard Repairs From minor dings to major damage someone here should be able to help you get your favourite board back in the water. Surf School Schools with qualified surf instructors offering lessons and courses with equipment hire to individuals or groups, whether you are a total beginner, an intermediate surfer or an experienced surfer looking to improve your ability. Shaper Craftsmen who can create a custom surfboard to your specifications. Surf Camp Surf camps can offer a variety of types of accommodation such as apartments, hotels, rooms, camping or dormitories together with food, surf lessons and group activities. Often included are guided surf tours of the best local spots along with surf hire, videos, photography, professional coaching and even some night life.


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A Study on Antiretroviral Therapy (ART) Naïve Patients On Different Regimens to Treat Hiv (NORTHIV)
This study has been completed.
Göteborg University
Information provided by (Responsible Party):
Lars-Magnus Andersson, Göteborg University
ClinicalTrials.gov Identifier:
First received: September 28, 2011
Last updated: October 2, 2011
Last verified: October 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The present study aims to compare efficacy, side-effects, and treatment adherence of three different treatment regimens given to antiretroviral naïve HIV-1 infected patients. Treatment will be initiated in accordance with the Swedish National Guidelines. In the twice daily (BID) arm (1), which could be considered as a standard regimen at present, lopinavir/ritonavir, is co-administrated with 2 nucleoside reverse transcriptase inhibitors (NRTIs) administrated BID. The first once daily (QD) arm (2) combines the protease inhibitor (PI) atazanavir/ritonavir with 2 NRTIs administrated QD, and in the second QD arm (3), the non nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz is combined with 2 NRTIs administrated QD. All drugs used in the study are licensed in the participating countries and patients will be followed as in clinical practice. Patients could optionally, after informed consent, be followed with additional measurements of HIV-1 RNA after 1, 2, and 3 weeks of treatment to asses the kinetics of viral decline after initiation of treatment.
|Drug: Lopinavir ritonavir Drug: Atazanavir ritonavir Drug: Efavirenz
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Study on ART Naïve Patients On Different Regimens to Treat Hiv (a Phase 4 Study)
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: RitonavirU.S. FDA Resources
Further study details as provided by Lars-Magnus Andersson, Göteborg University:
Primary Outcome Measures:
- Intention to treat (ITT)/time to loss of virological response (TLOVR) [ Time Frame: 144 weeks ]
- Virological failure (see 5.5.2 for definition)
- Treatment interruption or change of study treatment due to side-effects
- Treatment interruption or change of study treatment due to any other reason
- Missed to follow-up
1. HIV-1 RNA >50 copies/ml in two consecutive measurements from week 24 and on 2. any rise in HIV-1 RNA >50 copies/ml in two consecutive measurements after viral load <50 copies/ml has been reached 3. HIV-1 RNA never <50 copies/ml after week 24
Secondary Outcome Measures:
- Frequency of abnormal laboratory parameters [ Time Frame: 144 weeks ]Incidence of abnormal laboratory parameters at follow-up
- Adherence to study medication [ Time Frame: 144 weeks ]Proportion of doses taken correctly
- Frequency of adverse events [ Time Frame: 144 weeks ]Proportion of treatment discontinuations and changes due to different adverse events
- Changes in CD4 cell counts [ Time Frame: 144 weeks ]Changes in CD4+ T-cell count from baseline
- Changes in plasma lipids [ Time Frame: 144 weeks ]Changes from baseline in plasma lipids
- Frequency of hyperlipidemia [ Time Frame: 144 weeks ]Incidence of hypercholesterolemia and hypertriglyceridemia at baseline and follow-up
|Study Start Date:
|April 2004
|Study Completion Date:
|December 2009
|Primary Completion Date:
|December 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: lopinavir/ritonavir
400/100 mg BID + 2 NRTIs BID
Drug: Lopinavir ritonavir
400mg BD 100mg BD
Active Comparator: atazanavir/ritonavir
300mg+100mg QD+ 2 NRTI QD
Drug: Atazanavir ritonavir
300mg QD 100mg QD
Active Comparator: efavirenz
600mg QD + 2NRTI QD
Drug: Efavirenz
600mg QD
|Ages Eligible for Study:
|16 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female, aged 16 years of age
- HIV-1 infected as documented by a licensed HIV-1 antibody ELISA
- Ability to understand and provide informed consent
- Indication for antiretroviral treatment
- Antiretroviral naïve
- All clinical laboratory values not clinically significant
Exclusion Criteria:
- Subjects being pregnant
- Women of childbearing potential not practicing birth control
- Subjects with renal failure requiring dialysis
- Drug interactions with any of the study drugs that are not manageable
- Resistance to any of the study drugs
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01445223
Please refer to this study by its ClinicalTrials.gov identifier: NCT01445223
|Department of Infectious Diseases
|Goteborg, Sweden, S-41685
Sponsors and Collaborators
Göteborg University
|Principal Investigator:
|Magnus Gisslén, Professor
|Goteborg Universitet
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Lars-Magnus Andersson, Göteborg University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
Additional Information:
Edén A, Andersson LM, Andersson O, Flamholc L, Josephson F, Nilsson S, Ormaasen V, Svedhem V, Säll C, Sönnerborg A, Tunbäck P, Gisslén M. Differential effects of efavirenz, lopinavir/r, and atazanavir/r on the initial viral decay rate in treatment naïve HIV-1-infected patients. AIDS Res Hum Retroviruses. 2010 May;26(5):533-40. doi: 10.1089/aid.2009.0177.
Josephson F, Andersson MC, Flamholc L, Gisslén M, Hagberg L, Ormaasen V, Sönnerborg A, Vesterbacka J, Böttiger Y. The relation between treatment outcome and efavirenz, atazanavir or lopinavir exposure in the NORTHIV trial of treatment-naïve HIV-1 infected patients. Eur J Clin Pharmacol. 2010 Apr;66(4):349-57. doi: 10.1007/s00228-009-0763-z. Epub 2009 Dec 5.
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Vesterbacka J, Nowak P, Barqasho B, Abdurahman S, Nyström J, Nilsson S, Funaoka H, Kanda T, Andersson LM, Gisslèn M, Sönnerborg A. Kinetics of microbial translocation markers in patients on efavirenz or lopinavir/r based antiretroviral therapy. PLoS One. 2013;8(1):e55038. doi: 10.1371/journal.pone.0055038. Epub 2013 Jan 28.
|Responsible Party:
|Lars-Magnus Andersson, Principal Investigator, Göteborg University
|ClinicalTrials.gov Identifier:
|NCT01445223 History of Changes
|Other Study ID Numbers:
Northiv protocol 3.66
|Study First Received:
|September 28, 2011
|Last Updated:
|October 2, 2011
Keywords provided by Lars-Magnus Andersson, Göteborg University:
Antiretroviral therapy
randomised controlled clinical trial
Additional relevant MeSH terms:
Atazanavir Sulfate
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 Enzyme Inducers
Cytochrome P-450 CYP3A Inducers
ClinicalTrials.gov processed this record on September 25, 2017


text: Errand of Mercy Part 1 of 3. Script by Bob Harras. Pencils by Mike Deodato. Inks by Tom Palmer. Cover by Steve Epting and Tom Palmer. Quicksilver and Crystal journey to Wundagore Mountain to visit Pietro's dear friend Bova the cow-woman. Bova raised Pietro and his sister many years ago after they were born atop the snowy Balkan mountain. Once the two avengers enter Bova's cottage, they find her in very poor health and perhaps near death. But Bova's caretaker has an idea for Quicksilver! Go to the top of the mountain and convince the High Evolutionary to cure his very first creation! However the mutant speedster knows that little good happens atop that mystic mountain after dark! Yet for Bova's sake, he will make a run to the summit! Godspeed Pietro! Cameo appearances by the Black Knight, Black Widow, Captain America, Hercules, Vision, Luna, Marilla, Neophyte, Hera, Taylor Madison, and the High Evolutionary. (Notes: Bova previously appeared in X-Men Unlimited 2. This issue begins Mike Deodato's 2-year run as the primary penciler of the Avengers title. A new cover logo debuts for the Avengers series.) 32 pages. Cover price $1.50.


text: Our solutions showcases our ability to use Amazon Web Services to deploy Oracle Business Intelligence Enterprise Edition custom application deployment that can be offered as SaaS. We will use the OBIEE infrastructure from the cloud and connect to the clients data center for source and target data access. Secure, multi-tenancy hybrid cloud solution.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
As the Cedar Key Beacon wrapped up its 25th year of serving the island community in September, it seems fitting that Oct. 4-10 marks National Newspaper Week.
Newspapers across the country will be celebrating their historic and continuing contributions to our great nation, highlighting the vital functions they serve of gathering and dispensing information and documenting events both big and small.
If you currently subscribe or have subscribed in the past to the Cedar Key Beacon, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning Cedar Key Beacon and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
0 to 10 PyramidLanguage brain teasers are those that involve the English language. You need to think about and manipulate words and letters.
As with other word pyramids, start with a word, add a letter and (usually) rearrange all the letters to produce the next word. A clue is given for each.
Maybe your car can do 0 to 60 in 10 seconds, but can you do 0 to 10 in 60 seconds? Get out the stopwatch!
The hint gives the first and sixth words.
1. Exclamation
2. Negative
3. Heavy weight
4. British boarding school
5. Cherry seed
6. 14-line poem
7. Emotional strain
8. Cheeky
9. One of a suit (in cards)
10. Variety of peach
Hint1. O
6. Sonnet
Answer1. O
2. No
3. Ton
4. Eton
5. Stone
6. Sonnet
7. Tension
8. Insolent
9. Singleton
10. Clingstone
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
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text:
[Rough English translation from French language source]
For link, click here
'"It is that, the role of a substitute. "It is necessary to prepare consequently and make the job. We like all to play hockey, but the team should be helped to gain when one asks us to play", Lalime concluded.'


text:
See images from Himawari-8 in the new satellite viewer
This demonstration product is most suitable for people
with fast internet connection and high data allowance.
Low-definition satellite images
Satellite View Selection
03:30 AEST on Friday 22 September 2017 | Cloud/surface composite, Australia
Infrared image courtesy of the Japan Meteorological Agency. Blue Marble surface image courtesy of NASA.
IDY28000 Australian Government Bureau of Meteorology Bureau National Operations Centre Satellite Notes for 0600UTC Chart on 22 September 2017 Issued at 5:24 pm EST Friday on 22 September 2017 A thick cloud band associated with a cold front continues to move through southwest WA, with isolated embedded thunderstorm activity. Speckled cloud in its wake is bringing showers to the South West Land Division. Severe Weather Warnings continue across southern WA. Another cloud band extends from the Bass Strait, over Tasmania and into the Southern Ocean. This is a result of a cold front which wraps into a complex low pressure system well to the south of the country. Thunderstorm activity is evident over south-east Queensland and northern NSW, with high cloud from these storms spilling into the Tasman Sea. The rest of the country remains relatively cloud free due to a high pressure system off the east coast, except for some patchy high cloud over the south-east.


text:
Compare laptop deals and get the best discounts on popular brands, like Dell, HP, Apple, Lenovo, Acer, ASUS and more. Find the best laptops, from a MacBook to a Netbook, and combine quality and price for a cheap laptop. Not sure where to start? The FatWallet Laptop Buying Guide breaks it all down for you by price range and features to help you pick the right laptop fo your budget and needs.
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text:
Public Forums Report
Eastern Iowa Community Colleges
Fall 2012 – Winter 2013
Forum Report
Dated: 3/20/13
During the end of 2012 and into the beginning of 2013, Eastern Iowa Community Colleges (EICC) embarked on a comprehensive "listening tour" consisting of 22 forums. Students, faculty, staff, community leaders, business and industry members and friends of Scott Community College (SCC), Muscatine Community College (MCC) and Clinton Community College (CCC) (collectively "the Colleges") were invited to provide insights into how the Colleges are doing. Two facilitators, Ellen Kabat-Lensch (internal) and Sarah Johnson (external), sought feedback on what was going well, what could be improved and what should be considered as EICC plans for the future. The purpose of this report is to provide a narrative feedback on (1) what was heard, (2) what was heard most frequently, and (3) potential next steps for EICC. Throughout the forums, thousands of ideas were expressed and not all are captured within this report. However, summary worksheets from the forums are available for review. The purpose of this report is to share common themes, concerns and ideas that forum participants shared.
Key sections of this report include:
|Common Themes
|Community Interests
|Business & Industry Viewpoint
|Internal Constituent Feedback
|Fringe Points to Consider
|Potential Next Steps
While much of this report details suggestions for improvement, forum participants were quite complimentary of the Colleges and grateful to have been included in this process. A majority of the praise received focused on the Blong Center, affordability, dedicated staff, open access and flexibility. Overall, employees appear committed to their respective institutions and genuinely interested in the strategic planning process.
When asked what is "good" about the Colleges or why students select EICC Colleges, the following attributes were shared repeatedly: cost, convenience, quality instruction, transferability of credits to a four-year institution, accessibility, size, mission driven and caring staff. Community leaders, employers and students shared peak experiences and kudos for solid performance by the Colleges.
Submitted by:
Sarah Pohlmann Johnson


text:
And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
This charmer of a necklace features a trio of charms, inspired by vintage and antique charms. Each one is intricately hand-carved before being cast in the lost wax method. The charms are all different symbols of luck: the snake, a black agate and a hand with a small, conflict-free diamond.
- Snake 14k charm: 0.5" x 1"
- Agate heart: 0.75" x 1"
- Hand with small diamond: 0.3" x 0.75"
- 14k vermeil chain is 18" long
This product ships from the maker within 14 days, via USPS
Full refund issued for items returned within 14 days of receipt


text:
Seeing this deal possible makes my mind wander into irrational thought.
Why not offer PG and/or Danny plus West (expiring) and picks? In all actuality it would probably really have be centered around Roy and PG which would probably be better. Keep Danny as a shooter and West's savy veteran leadership next to Dwight and it would be scary. However, I know he doesn't want to be here, won't sign an extension, and we'd probably have to take back some bad contracts as well. Plus, I will take Roy in a landslide if it were a likability contest. Then again the same can be said for Dwight in the talent/athleticism department. I actually don't know if we can even trade Roy yet either, you new CBA gurus would have to enlighten me on that one.
/end irrational thought
It is just somewhat depressing to think that LA will still be relevant for the next 5 years at least assuming he signs the extension. I want to see them in the doldrums for once/laugh at the moronic part of their fanbase that has unrivaled levels of arrogance. There HAS to be another team willing to risk it all on Dwight and has some assets that is better than what Orlando is getting in the deal.
Or maybe not. Oh well.