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Topic: Systemic Chemo - Anybody have any luck with it?
Hi everyone,
My dad was diagnosed about a year ago with intrahepatic ccc. His tumor is quite large and he was told that it was inoperable. He tried chemoemobilization without success and has had to have his stent replaced every six weeks or so. This last time the doctors at Mayo placed 2 stents and after just a few days his usual symptoms reappeared. He recently had a scan that showed lesions on his liver and is planning on taking chemo to hopefully keep the cancer from spreading.
My question is, have any of you had results with systemic chemo? If so, what type of chemo did you have and how severe were the side effects?
Thank you so much for sharing your information.
My thoughts are with everyone on this board struggling with this ugly disease.


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Media Contact: TPWD News, email@example.com, 512-389-8030
March 17, 2006
Scientists Offer Tips for Dealing With Bats
AUSTIN, Texas — Millions of Mexican free-tailed bats are returning to Texas from their winter homes in Mexico, and while research is revealing an increasing number of bat benefits, scientists say there are some common-sense steps schools, businesses and homeowners can take to coexist peacefully with bat visitors.
The bats return to the southwestern U.S. each year where they will spend the summer raising their young. Each mother gives birth to a single baby called a pup. At the first signs of cold weather in the fall, they will begin returning to warmer Mexico.
Research has shown Mexican free-tailed bats gobble up moths that lay eggs on crops, eggs that develop into larvae that eat cotton, corn, and other important agricultural plants. University researchers have documented that this can save farmers significant dollars in avoided crop losses and decrease the need for pesticides.
"While we are happy to see the bats arrive in Texas each year, they sometimes take up residence in places where they are unwelcome," said Barbara French, conservation officer with the nonprofit Bat Conservation International.
"A few bats in an attic are not likely to be a problem, but bats should not be allowed to enter interior living or working quarters. When necessary, bats can be safely evicted from buildings using proper bat exclusion methods. Openings used by bats to exit the building can be fitted with a valve, generally a simple smooth tube or netting through which bats are able to exit but not re-enter the building. Valves should be left in place for one week to make certain all bats have gotten out, and then openings can be permanently sealed shut," French said.
Proper bat exclusion techniques protect both people and the bats. For more information about proper bat exclusion techniques, see the Bat Conservation International Web site, click on "projects" and then "bats in buildings."
"If you want to keep these voracious insect predators around, you can install a bat house near the place they are living before evicting them," said Meg Goodman, Texas Parks and Wildlife Department bat biologist. "When the bats are unable to get back into the building, they will have an alternative roost."
Building bat houses is a great project for schools and Scout troops, Goodman said. Wood shop classes can get involved and once the bat house is installed, classes can observe the bats and monitor their own bat colony. For more information about bat houses, visit BCI's Web site under "projects" then "bat houses."
While it is true that some animals, including bats, contract rabies, Goodman said people should keep this in perspective. She said less than one half of one percent of bats in natural populations get rabies.
"But always be safe," Goodman emphasized. "Do not handle bats, and educate children about the dangers of approaching any wild animal."
Mexican free-tailed bats form large colonies in bridges and caves throughout the southwest and make spectacular nightly emergences in the summer.
Texans are proud of their unique bat colonies. For more information about when and where to see bat emergences, visit the BCI Web site under "Discover" then "Texas Viewing" or see the TPWD Web site Nature pages.
Property owners or managers, schoolteachers and others may contact Barbara French at email@example.com or (512) 327-9721 or Meg Goodman at firstname.lastname@example.com or (512) 912-7042.
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subset: commoncrawl


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Identity Protection and Credit Management
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text: Anyone who grew up in or just around the 1960s knows who Peter Max is; I saw his artwork on my parents' Beatles covers and even a Bicentennial-era postage stamp. One of his Lady Liberty posters — signed by him and personally inscribed to me — adorns the Dallas Voice office walls. So it wasn't a difficult decision to say "yes" when he offered to design the cover of our publication with an exclusive rainbow print, just in time for his appearance in North Texas. This is a collectors' edition, my friends. It's a little bit of history in your hands. Thanks, Max!


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A meth lab discovered in Henry County has led to the arrest of two people. Troopers from the Kentucky State Police Post 5 in Campbellsburg went to 221 Pendleton Loop at approximately 1 a.m. Friday. During a search of the residence, Troopers discovered a meth lab, as well as several ingredients used in methamphetamine production, inside the home. Outside the residence, Troopers discovered several bottles used to cook methamphetamine. There were no children present in the home.
By SARAH BEACH
The Trimble Banner Intern
Excelling at college entrance-exams can be hard, but 1,400 seventh graders in Kentucky did just that.
Two of these students attend Trimble County Middle School — Jenna Rowlett, of Bedford, and Zachary Wright, of Milton.
Western Kentucky University's Center for Gifted Studies honored them on WKU's campus on May 25. They sat in Diddle Arena with around 400 other seventh graders in a ceremony to be recognized for their big achievement.
Hannah Hudson, Milton, has achieved a place on the University of Evansville Dean's List for academic achievements during the Spring Semester 2012. Hudson is majoring in Science Education.
To make the Dean's List, a student must earn at least a 3.5 grade point average on a 4.0 scale.
Milton residents Michael Gonterman and Konnor Kimmel are among incoming freshmen and transfer students have accepted merit-based scholarships to attend Eastern Kentucky University. Gonterman, a 2012 Trimble County High School graduate, earned a Founders Scholarship. Kimmel, a graduate of Columbus East High School, received a Presidential Scholarship.
Kindoll Ann Jones
Kindoll Ann Jones graduated from Jefferson Community College on Monday, May 7, 2012, with a major in Nuclear Medicine Technology. She became a Certified Medical Nuclear Medicine Technologist on May 4. She is also a member of Phi Theta Kappa Honor Society.
Kindoll is the daughter of Stanley and Debbie Jones and has an older brother, Josh. She is the granddaughter of Sue Nelson and Gene and Nancy Jones.
Angela G. Stethen
Donna Reeves, a 1981 Trimble County High School graduate, will be attending the 2012 summer institute Entrepreneurship for the Public Good at Berea College.
In an intensive 8-week program, Reeves and 14 other Berea College students will learn to recognize opportunity and use it to enhance local economies. The participants will travel the Appalachian region gaining insight into the area's economic conditions. They will learn social networking techniques and ways to manipulate online resources.
The Summer Reading Fun program at the Trimble County Public Library gets underway this week. Besides reading for fun and prizes, the months of June and July are packed with exciting, free programs! Following is the schedule of June fun events planned for the library.
Louisville Gas & Electric Company, which operates an electricity-generating station at Wises landing on the Ohio River in Trimble County, has made a corporate donation, which ensures the purchase of a new food trailer for the Milton Fire & Rescue Department.
The department's Station No. 2, located on U.S. 421N near the "crossroads" intersection where Palmyra Road and Old Milton/Bedford Pike cross U.S. 421, was a total loss as a result of the tornadoes that swept through Trimble County on Friday, March 2.
The Trimble County Fair Board will salute military personnel from yesterday and today during next month's Trimble County Fair.
Copyright © 2017
The Trimble Banner is your source for local news, sports, events, and information in Trimble County, KY and the surrounding area.


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19 fun car road trip activities
Turn an ordinary drive into a world of fun adventures and possibilities. more
Type in ADHD into your search engine and you'll be bombarded with information - some of it factual, some of completely wrong.
ADHD is a clinical condition that affects up to 10% of the population - children and adults.
This is how the Royal Australian College of Physicians describes the condition in its Draft Guidelines on ADHD: "Attention deficit hyperactivity disorder (ADHD) is a common condition which begins in childhood and often persists through adolescence and into adult life. The core symptoms are poor impulse control and lack of sustained attention.
"Many individuals with ADHD have one or more associated problems, such as learning difficulties, anxiety, autism spectrum disorders or tics. People with ADHD often find it hard to enjoy life to the fullest and achieve their potential.
"The flow-on effects of ADHD can have a significant impact on families, schools, workplaces and the community more broadly."
It's been described as a "neurobiological" condition but it seems there is still not enough evidence to categorically say what's physically happening in the brain to cause ADHD. But many believe it stems from an imbalance in the brain's neurotransmitters, chemical substances which relay impulses in the brain.
The RACP draft guidelines continue: "Attention-deficit hyperactivity disorder (ADHD) is defined as a persistent pattern of inattention and/or hyperactive and impulsive behaviour that is more frequent and severe than is typically seen at a given stage of development.
"Symptoms are usually present from early childhood, they tend to become particularly troublesome when the child starts school, and they may remain troublesome across the lifespan.
"The symptoms of ADHD are associated with impairment in educational, social and emotional function."
This article was written by Fiona Baker for Kidspot, Australia's best family health resource. Sources include Michele Toner, Living with ADHD, Raising Children Network and the National Health and Medical Research Council.
Last revised: Friday, 16 July 2010
This article contains general information only and is not intended to replace advice from a qualified health professional.


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Conflict resolution skills, negotiation prowess and media savvy are essential for business leaders, whether they work on a farm or in a board room. DCHA offers one simple tip for leaders aspiring to improve their skills - apply for the DCHA Merck Animal Health Leadership Program.
Six program participants will receive valuable hands-on training in such areas as working with the media, conflict resolution and negotiation skills. They also will serve on a DCHA committee and have opportunities to meet and interact with fellow calf and heifer raisers, as well as industry leaders and experts from across the country. In addition to training, participants will receive all-expenses-paid travel to the 2013 DCHA Conference in Lancaster, Pennsylvania, and the World Dairy Expo in Madison, Wisconsin.
DCHA and Merck Animal Health remain committed to the development of the next generation of dairy leaders through their sponsorship of the fifth Merck Animal Health Leadership Program.
"Merck Animal Health is pleased to be able to support this important initiative that offers individuals the opportunity to take a more active role in the industry and further develop their business acumen," says Rick Jackson, dairy marketing manager for Merck Animal Health. "The program also provides us the opportunity to give back to the dairy industry and the professional men and women who work so hard each day to make it a success."
"The program offers an outstanding opportunity for dairy calf and heifer raisers to sharpen their business skills, network within the industry and become more involved in DCHA," says the organization's president Darin Mann. "Many of our former program participants have gone on to take leadership roles within their communities and even within our own organization."
Application Guidelines
Custom dairy calf and heifer raisers and dairy producers who raise their own calves and heifers are eligible to apply for this 12-month program. Six class members and two alternates will be selected based on their dairy industry and community involvement, in addition to their interest in the dairy calf and heifer industry. Applicants do not need to be a DCHA member to apply. The complete leadership program criteria and application are available on the DCHA website at www.calfandheifer.org. Applications will be accepted until Jan. 30, 2013.
"This past year I had the opportunity to be nominated and selected for the 2012 Merck Animal Health Leadership Class. It was an honor to be selected, and the class has provided me with valuable business tools, conflict resolution (handling difficult decisions), and outstanding networking capabilities," says Abbie Heid. "DCHA is a great organization to work with and I am glad I was given this amazing opportunity, and I hope others find it as rewarding as I have."


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Now… More Than Ever
EP Editorial Staff | June 2, 2006
The U.S. is not the only nation worrying about outsourcing and manufacturing job losses. Japan, Brazil, China and India are, too. In the cases of China and India outsourcing from other parts of the world has put pressure on them to depart from low-volume, marginal quality to high-volume, high-quality output. In most cases the manufacturing job loss here and elswhere was caused by higher and higher levels of automation and productivity-increasing techniques (which began in the U.S. in the late '50s). Industrial automation puts the pressures for continuing competitiveness squarely on the shoulders of our industrial maintainers, be they mechanics, electricians or technicians. Herein is the BIG problem.
Formal maintenance skills and knowledge training will be the weakest link in industrial competitiveness for the next two decades, or more-far worse than shortages of production workers.Consequently, we must move NOW at local, state and national levels, as well as at the individual company level, to accelerate formal equipment- and jobspecific maintenance skills training processes.
Maintenance training grew out of apprenticeship training programs from the early 1900s though much of the 1970s and trade schools that sprang up in the early- to mid- 1900s.World War II gave birth to methods known as "Training Within Industry "(TWI), which were followed by several decades of vocational-technical programs in high schools and community colleges/tech schools and Industrial Arts programs that put significant emphasis on hands-on work.
These days, apprenticeship programs have almost disappeared and there are very few vo-tech programs targeting trade and industrial jobs. Because of this-and because so many companies cut back on their training departments and capabilities over the past-too many maintenance workers today have not been formally trained to do the work we ask them to do day in and day out. (In small- to mid-sized companies, we estimate this number to exceed 85%.)
Exacerbating this already sorry state of affairs is the other maintenance skills bullet zooming toward many industrialized nations as the "Baby Boom" generation begins reaching retirement age. The U.S Department of Labor has been predicting shortages in the maintenance and repair occupation arena due to aging "Boomers" for years.
State and Federal initiatives for re-training outof- work adults and youth (especially with 4.6% national unemployment) will NOT meet the needs of our capital-intensive infrastructure, nor our advanced manufacturing competitiveness. So far in 2006, the status of America's formal maintenance and reliability training looks abysmal. Lack of formal training plus the looming skills shortage will put many of our top 11 equipment-intensive business and industrial sectors (well beyond manufacturing) representing over 38% of our GNP (over $8 trillion in 2004) at risk. Economies of 14 states with the highest "gross state product"from manufacturing also are at risk.
We need to pull out all the stops and aggressively pursue formal maintenance skills and knowledge development in our plants, facilities and schools.NOW. Government leaders must be made aware how jobs in their districts are at risk because of the maintenance skills shortages and a gross lack of a skills training infrastructure. NOW.
NOW (more than ever) is the time to lobby Congress for "skilled trades training tax credits" and "competitive skills development tax credits" for performance-improving training and development in our equipment-intensive businesses. MT
(Look for more information on our continuing "Status of Maintenance & Reliability Training in America Survey" in future issues of MAINTENANCE TECHNOLOGY)


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French Silk Pie
My little brother A came to Boston for a visit a couple weeks ago. Although, I suppose calling him my little brother is a bit misleading. He's growing up fast and just graduated high school this past May. And he towers over the entire family at 6'4″.
As with most people who come to visit, I asked A if he wanted me to bake him something while he was here. He immediately responded "French Silk Pie". Now I've never actually had French Silk Pie let alone baked one. Apparently, it's A's favorite dessert though. He's even baked them himself in the past.
After I found out he had baked his own French Silk Pie, I decided it would be more fun to bake the pie together than for me to bake it for him. I figured we could get some quality sibling bonding time in the kitchen.
A and I had a good time making this pie. He had never made a crust from scratch before and this one was really easy. You just crush up some nuts, mix in some butter, and press it into the pie plate. It can't get much easier than that!
We whipped up the mousse and filled the shell. Then came the painful part, letting it set. We ended up letting the pie chill in the fridge overnight. The next night after dinner, we topped it with some freshly whipped cream and chocolate shavings. I can't comment on how this compares to other French Silk Pies out there, but everyone really enjoyed this pie. I'm pretty sure A had 3 pieces himself before heading back to the Midwest.
One Year Ago: Buttermilk Cupcakes with Chocolate Swiss Meringue Buttercream
Two Years Ago: Red White and Blue No-Bake Frozen Cupcakes
French Silk Pie
Yield: 8
For the Crust
8 Tbsp chilled salted butter, cut into pieces, plus more for pan
1/3 cup pecan halves
1 1/3 cups all-purpose flour
1/4 cup firmly packed light-brown sugar
1/4 tsp salt
For the Filling
12 Tbsp (1 1/2 sticks) salted butter, room temperature
1 cup sugar
3 ounces unsweetened chocolate, melted and cooled
1 1/2 tsp vanilla extract
3 eggs
Whipped cream, for serving
Chocolate curls, for serving
For the Crust
Preheat oven to 325 degrees. Butter a 9-inch pie plate; set aside. Grind pecans in a food processor, or chop very finely with a knife. In a medium bowl, combine flour, pecans, sugar, and salt. Cut in cold butter with a pastry cutter until mixture resembles coarse meal. Press firmly into prepared pie plate. Bake until golden, 20 to 25 minutes. Transfer to a wire rack to cool.
For the Filling
In the bowl of an electric mixer fitted with the paddle attachment, cream butter and sugar until light and fluffy, about 2 minutes. With machine running, gradually add melted chocolate and the vanilla. Add eggs, one at a time, beating at medium speed for five minutes after each addition. Pour filling into cooled pie crust. Cover with plastic wrap, and transfer to the refrigerator to cool for at least 4 hours and up to overnight.
Just before serving, top pie with whipped cream, and decorate with chocolate curls.
Recipe from Martha Stewart
12 Responses to "French Silk Pie"
I made one of these once and it was grainy because I screwed up on the butter or something, your looks perfect! Must give it a try, thanks!
That looks SO good. French Silk pie is one of my favorites too, but I have never tried making it.
French Silk Pie is one of my favorites.. and it's also one of my favorite blizzard's at Dairy Queen! I'm going to have to give this a try..
I think I've had only one French Silk Pie in my lifetime. I must change that statistic haha. Your photos look fantastic.
Wow, that looks delicious! I've never made it before either, but I'll have to give it a shot! And I feel your pain about the "big" sister thing…my little bro calls me shorty which took some getting used to : )
What a wonderful pie! It's strange how I have no problem with the raw eggs in this pie, but they gross me out in spaghetti carbonara 🙂
I too love french silk pie, but have never made one. You did such a good job and made it sound simple, I will have to try making one.
This looks divine! I'm not much of a baker, which is why I love heading over to your site for inspiration!
Awww that's so nice you baked it together 🙂 It looks amazing and so, so beautiful!
that looks so delicious!
Ive tried this pie and it was perfect. I didn't make the crust because I needed it in a hurry so I just baked off a pie shell instead. It was breath taking. I so love this recipe.
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text: This website presents general information about Finnegan, Henderson, Farabow, Garrett & Dunner, LLP and the services that the firm offers to clients. The information is not intended as legal advice, and you should not act upon it without seeking professional legal counsel. While we are happy to have you contact us by telephone, surface mail, electronic mail, or facsimile transmission, merely contacting Finnegan or any firm attorney does not create an attorney-client relationship. An attorney-client relationship with the firm or any of its attorneys will only be established after the firm determines that it is willing and able to accept the engagement and the firm and the client enter into a written engagement agreement. Please wait until an attorney-client relationship is established before you send Finnegan any information or documents that you consider private or confidential. Information that Finnegan receives from a source other than a pre-existing client may not be treated as private, confidential, or otherwise protected from disclosure.


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Category: girls' names from the bible
The Bible contains hundreds more boys' than girls' names, but the female names in its pages are among the most beautiful and enduring of Western culture. It's difficult to pick just a handful of our favorites. Setting aside such timeless beauties as Anne, Mary, and Elizabeth, we spotlight these choices that combine distinctiveness and style.
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(These featured recipes will be added to the archives category for Recipe Favorites. Check out the whole list of South Beach Diet Friendly Thanksgiving Recipes for more ideas, including ideas for leftover turkey.)
See more favorite recipes I've featured on Friday by using the label Friday Favorites.
Are you celebrating Canadian Thanksgiving this coming Monday? If so, please let us know in the comments about what Thanksgiving favorites are going to be on your menu.


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First time in a long time, I've been happy with the team that was constructed, and now they struggle. I blame the coach.
Paul Georges D prior to Sunday Defensive Rating was at 88.. That is GOAT status, I don't know how he's back up to 98.. His D on manu was ferocious.
He shut him down, Blocked the crap out of Green..
We are panicking way too early. We have had one home game and 3 road games, Everybody needs to chill. We'll be fine.
Why all the hate all of a sudden is focused on Frank? What did he do that year in a half that does not warrant him a break?
After all he led us to the playoffs after we were toasted with JOB, Gave us the 3rd seed after a full season. Now we want him
gone after 4 games???????? Do the Celtics want Doc gone as well?????
Makes zero sense, Who was coaching the team under Frank? How has he not shown that he could lead this team. The team is just playing sloppy.
Cut them some slack. This is why Success as a franchise is so poisonous, Now that we have high standards after making
the playoffs all of a sudden we are a power house team? I mean the Thunder are 2-2 as well.
To the people that wanted DC, Lou, Barbosa and Dhante! It's just too early. Some of you forget how bad DC was at times, How
Imcopentant he was at passing the ball. He simply didn't have what it took to run our offense. I mean how soon do we all forget??
How bad Lou was and his 5-8 missed dunks per game. How every time Lou shot the ball we all cringed. I applaud the team
for making a gamble this offseason. We would not have grown out them, We really would have been a treadmill team with
those players aboard. Boy is Leandro lighting the world on fire with the Celtics. On paper the additions we made>>>>
last years players. I feel very confident in us making the playoffs. We'll catch our groove soon. It's a 82 game season people
relax. You can't hit the abort button and break the team up after 4 games. We'll have a good feel for this team once
were close to the All-Star break. We are missing our best player and were at .500 I'll take that to bank all day.
If anything this is a great lesson for you get rid of Danny cult leaders, The man means too much for this organiztion.
He and Dwest are the only ones in the team you know can create for themselves. Once Danny comes back!
Paul and Green urgency of scoring should vanquish, Making them play their own game. We all have to come to the realization
that Paul George at this state cannot and will not lead the team in scoring, It's just not his mindset. It's in the Nature of the
beast.... Paul shies away from the ball, That's why Danny is so good... The dude has a killer alpha dawg mentality. To me the whole
2-2 ordeal isn't huge. But the way Paul is playing is just shocking. I mean he starts off the 1st half great then completely goes MIA in the
second half. That is not franchise esque! His tendencies are just shoccccccking, he isn't attacking the Rim and is shooting contested shots.
Mahinmi has five years in the NBA, Green was drafted 5 years ago, DJ has been the starting point guard of an NBA team, Young has been in the NBA for a while, we are not talking about rookies or players with huge potentials here, they have been the same players they are right now for a long time.
If the Pacers HAD the players the Heat does, no one would be complaining about losing ONE game. The Pacers DON'T have the Heat players, and they could just as easily be 0-4 instead of 2-2.
Tonights game should be interesting to say the least. Lets see how the team plays against the Hawks, and who shows up and who doesn't. I'm personally not in the camp that Granger's injury is why the Pacers are moving around the court like a blind man, and playing poorly against poor teams.
I understand, not happy though, the shellacing the Pacers took against the Spurs. The Spurs are a premier team. Lets see if the Pacers come to meet the challange of the Hawks.
"Your course, your path, is not going to be like mine," West says. "Everybody is not called to be a multimillionaire. Everybody's not called to be the president. Whatever your best work is, you do it. Do it well. You cease your own greatness when you aspire to be someone else."
I see a guy with good size for the position who is a decent catch and shoot guy but not much else on that end of the floor. For a guy with his size and athleticsm, he's a relatively poor finisher around the basketball. Despite his summer tutoring, he still looks like a really poor ball handler. He doesn't move very well without the ball. He seems to be working a bit on his post game but hasn't really developed it any way. He has not shown an ability to get his own shot with ease.
And I'm not sure a guy scoring 16-18 ppg as the lead option on a bad team in the WAC proves that one has huge offensive potential.
"I had to take her down like Chris Brown."
-Lance Stephenson
This may help some of you that need a primer.
Why do the things that we treasure most, slip away in time
Till to the music we grow deaf, to God's beauty blind
Why do the things that connect us slowly pull us apart?
Till we fall away in our own darkness, a stranger to our own hearts
And life itself, rushing over me
Life itself, the wind in black elms,
Life itself in your heart and in your eyes, I can't make it without you
The former player that would have really made a difference right now is BRush.
Let me take my other post back, that group isn't necessarily better, across the board, but they are more defined and would provide some continuity in a situation that is a messed up jigsaw right now.
Mike Wells @MikeWellsNBA
Vogel: "no motivational speech will replace Danny, we just have to play"
Pretty sure it's tendinosis. This diagnosis actually better matches the natural history of what we know of Granger's knee issues as well.
I think some of you guys need to read the press release and then go look up tendinosis.
It's tendinosis, not tendinitis. Apparently there's a huge difference. And a bad one. Tendinitis is a generic inflammation that generally goes away with rest. Tendinosis is not an inflamation, but a degenerative condition that's often mistaken for tendinitis.
@ Mike, @doc, thanks. The words are very close, even though the meaning has some similarities, the actual diagnosis and treatment is not. Thanks for clarifying, as I'm sure I wasn't the only one to misread or fail to appreciate the differences.
Why do the things that we treasure most, slip away in time
Till to the music we grow deaf, to God's beauty blind
Why do the things that connect us slowly pull us apart?
Till we fall away in our own darkness, a stranger to our own hearts
And life itself, rushing over me
Life itself, the wind in black elms,
Life itself in your heart and in your eyes, I can't make it without you
I see a guy with a beautiful, natural shooting form that gets such nice lift to potentially shoot over anyone at will.
I see a guy who's trying to figure out how to play at both ends of the floor and have enough energy to do so. He looks like he takes puffers on offense so that he can dominate on defense. At least to me, that's why he doesn't move so well off the ball.
I see improved handles from last offseason, but goes back to old bad habits under pressured circumstances.
I don't think he has the size/bulk to really move his post game forward meaningfully... but clearly has changes in his body over when he was drafted (he's added about 15 lbs since his college days).
That's the fun of being a spectator. We can see different things.
My concern is that George seems to be the kind of player that needs the coaches to really push him hard. IMO, he needs someone to hold him accountable to live up to his potential. Vogel doesn't seem like that kind of coach.
If games are won and lost on a calculator and piece of paper, then why do we bother to play them?
Well, this just means that PG has to grow up much sooner than we thought. He may not want it...but he's going to have to be "The Man" now.
Frankly, I don't think that PG is ready nor willing to be "The Man".
Can someone give him the same stuff that West and GH takes before the start of each game so that he's more aggressive?
Ash from Army of Darkness: Good...Bad...I'm the guy with the gun.
A little sense of humor will help the medicine go down, mate.
"Look, it's up to me to put a team around ... Lance right now." Kevin Pritchard press conference
Time to hit the cellar for Zeller!!
Being unable to close out a game in which you have a comfortable lead in the 4th Q = Pulling a Frank Vogel
Pietrus is a solid wind defender and 3pt shooter....but the guy has a low basketball IQ and poor shot selection.The Pacers have already reached out to the agent of free agent swingman Mickael Pietrus as a possible replacement in the lineup
Are there other FA options?
Ash from Army of Darkness: Good...Bad...I'm the guy with the gun.
Guys, Paul isn't the one that has to step up his game. Hill and Roy are the 2 making the big bucks. Time to start playing like you are worth the $$
Being unable to close out a game in which you have a comfortable lead in the 4th Q = Pulling a Frank Vogel


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Turn Down For What? [NEWTUBE THURSDAY VIDEOS]
I "Woke Up", tipped my "Cup Up, Top Down" drinking on some "Activist" leaning with that "Collard Greens", and that's how we get our "Pimp On"!
NewTube Thursdays with Schoolboy Q, Waka Flocka, Kirko Bangs and Dough Boyz Cashout! #TurnDownForWhat
Watch the hot new videos inside.


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Moderators: Timko, Fritz, Solty, Booter, Blake_T, Frank Delicious
My slightly domey one isn't bad either, got me my first ace.Leopard wrote:flat Champ Coyotes are the shit
Anode|ION|JOKERi|MD2|FD|TD|PD|LEGENDaParks wrote:If the posts on this forum are any indication, the PD is like a Teebird with sunshine coming out of its butthole so hard that it flies faster.
dgdave wrote:I've gone to the Ti buzzz over these. Still real nice
JR wrote:Cro would be a good pair because Gator may leave too large a gap in between the two because in too little headwind to straighten out the Gator the Coyote would flip so getting a straight shot would need guestimation of initial hyzer angle compensation for the Coyote to flip to flat and the Coyote glides too much and flips too easily in headwinds easily winding up way way of sideways in case of a misestimation of the headwind. Good Z Buzzz and for more wind Glo Z Buzzz would work too. And the early Cro i had faded more like the Glo Z Buzzz but i gave my Cro away so long ago that with changed form and more power i can't say about the headwind flips and fades of the Cro.
JR wrote:Have you tried the Spider? That could pair well with the Coyote too for straighter overall performance with the con of not having straight then automatic fade as hard as the Cro does. The Spider does handle winds much better than the Coyote though. That could be another pair to try out.
JR wrote:My only Champ 167 is lighter due to LED night golf requirements (at times one disc rounds) than the Star and DX max weight i have. The flight of the C 167 plus a light LED seems to be otherwise the same except a hair more fade that usually does not change shot planning and required form. Tunnels are the only differences. And of course the hard Champion plastic is slick and the Star ain't the grippiest blend either. I think the Champ should last a long time but FH is fussy for clean form. The bead doesn't make clean releases easier. Buzzz for straighter shots and Zone or Gator for automatic fades FH would probably be better in heavier winds for safety against the elements and user error. Spider is fine for shorter approaches though.
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"Is it all naturally derived?" asks New York Mets catcher Anthony Recker during a taste-test of a new plant-based burger. Apparently the jock has a reputation for avoiding anything with preservatives and is cutting back on his red meat consumption.
But that doesn't stop him from chowing down on a meat substitute composed of 26 ingredients compared to a 100 percent all-beef patty. Hear that shrieking in the distance? That would be the Food Babe pulling her hair out because the ingredient list contains words she can't spell.
Beyond Meat, the creators of this GMO-free soy and pea protein are pushing their product for all the right reasons, hoping to knock meat consumption by every man, woman and child in the United States 25 percent by 2020, dubbing their movement the 25/20 Vision.
"We want all of the good and none of the bad. We want to eat delicious meat but we don't want any of the bad stuff that goes along with it. Is that too much to ask? Well no, actually. Not since we created real meat from plants. Brilliant, right?" says Beyond Meat's website. "Now it's time to make a real difference. We want to reduce the world's consumption of animal meat by 25 percent by 2020. Massive, we know. But it would do wonders for human health, for the environment, for conservation of natural resources and for animals. It's worth a fight."
The person who came up with the idea to put a fried onion ring on an all beef patty was brilliant, not the creators of the latest soy burger with an anti-meat agenda.
Unless you count them using professional ball players' approval as the gateway into American hearts for marketing. I keep forgetting how we're a bunch of puppets controlled by celebrity trends and influences.
But like it or not, Beyond Meat and similar companies are some of our industry's newest competitors in the consumer market and will be even more so in the future. And while I believe the taste of beef literally sells itself when compared to a soy burger, it's important to heed with caution when dealing with these types of companies, especially when their market it built on the back of stepping on yours.
In the meantime, I'm going to keep on enjoying my non-organic, 100 percent beef with plenty of butter on my GMOs – while wearing a New York Yankees shirt.


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Ambulance staff in the district were yesterday given details of Yorkshire Ambulance Service NHS Trust's plan to change its A&E services.
The proposed changes, which the Trust says have been developed following consultation and negotiation with the recognised trade unions, UNISON and Unite, are aimed at ensuring the region's ambulance service delivers the best possible clinical outcomes for patients and achieves a sustainable level of performance in response to emergencies and balances its budget.
The Trust's plan contains a series of detailed changes, but mainly focuses on significantly increasing its number of qualified paramedics over the next five years and retaining a tier of paramedics with additional clinical skills.
In addition, the Trust says it plans to build upon its current clinical support worker arrangements by introducing a role, known as an emergency care assistant, to work alongside paramedics on ambulances. The Yorkshire Ambulance Service says they are trained to deliver an appropriate level of clinical support to their paramedic colleagues and to undertake emergency "blue light" response driving.
The trust maintains the proposals will ensure there will be no reduction in the overall number of staff working on the A&E emergency service and no compulsory redundancies.
Other elements include: pay protection arrangements to ensure no A&E staff have any reduction in their current level of pay over the next five years and a commitment to remain aligned to the national terms and conditions of employment for NHS staff.
David Whiting, chief executive of Yorkshire Ambulance Service, said: "We have worked extremely hard to produce the right A&E workforce plan for the Trust over the next five years. This has involved detailed negotiations and consultation with trade union representatives, which has led to this improved final plan being put to our staff.
"Our absolute focus throughout this process has been to ensure that we continue to deliver a safe, responsive and high quality service to the people of Yorkshire over the coming years. We have also sought to ensure we protect the current employment and future career prospects of our A&E staff as much as we possibly can during these challenging economic times."
The Trust will now await the final and formal response from its recognised trade unions to the proposed changes. If the changes are agreed, then the Trust will seek to implement them as quickly as possible.


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Injuries have Oakland using backup plans
CLEVELAND -- The decision to bring up first baseman Daric Barton from Triple-A underscores just how severely Oakland has been affected by injuries this season.
In addition to Josh Reddick, who was placed on the 15-day disabled list retroactive to May 7, the group of injured outfielders includes Coco Crisp and Chris Young. Crisp has a strained left hamstring, and Young has a strained left quad.
"[Crisp is] moving around better. He's not feeling it when he walks around," manager Bob Melvin said. "I think he took a few swings off the tee. But I still feel like Chris Young has a better chance to come [back] before Coco does."
Melvin also mentioned a few injured pitchers. He said that Brett Anderson, who is dealing with a sprained right ankle, threw well in his bullpen session and is "feeling as good as he's felt here in a while."
Melvin also reaffirmed that he expects Jarrod Parker, who has a strained neck, to make his next start, scheduled for Saturday in Seattle.
"Very rarely is everybody going to be 100 percent," Melvin said. "Part of putting together the roster in the offseason by the front office was based on flexibility and being able to combat injuries.
"We never expected to have three of our outfielders on the [disabled list] at the same time, but a guy like Brandon Moss makes it a lot easier. He can go from first base and go to the outfield rather easily. We still have four good outfielders here right now. It's just a little different dynamic at first base."
On Wednesday against the Indians, Oakland started Seth Smith in left, Yoenis Céspedes in center and Moss in right.
Mark Emery is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Nursery Rhyme
Wedding Rhyme
Counting-out Rhyme
Nursery Song
Nursery Charm
Jump Rope Rhyme
Children's Song
Counting-Out Rhyme
Action Song
Finger Play
Lap Rhyme
Hand Clapping Song
Please contribute a traditional song or rhyme from your country.
Travel to far away places with our new E-Books Kid Songs Around The World and Lullabies Around The World
Whoever the children are in your life - your kids, your grandkids, your students, even yourself (in your heart) - Mama Lisa's E-books are wonderful ways to help them experience other languages and cultures.
In Kid Songs Around The World we've gathered 100 of our favorite songs and rhymes from all the continents of the globe.
Each song includes the full text in the original language, with an English translation, and most include sheet music. All include links to web pages where you can listen to recordings, hear the tune or watch a video performance. Each includes a beautiful illustration.
Many have commentary sent to us by our correspondents who write about the history of the songs and what they meant in their lives.
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Over 50 lullabies and recordings from all over the world. Each Lullaby includes the full text in the original language, with an English translation.
Kid Songs Around The World and Lullabies Around The World are downloadable e-books, which you will gain access to immediately. (They are not physical books.)
We hope these books will help foster a love of international children's songs!
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Music, culture and traditions from all around the world!
This article was written by Monique Palomares who works with us on the French version of Mama Lisa's World. We recently posted a Breton song about dwarves from the region in France known as Brittany. The song is called Ar C'horred (The Dwarfs). There's a verse in the song [...]
Grit, or constancy of effort over time, is a key to success in life… this holds true for bothstudents at school andadults at work. Grit is more predictive than IQ and SAT scores. When we talk about grit, we're talking about "passion and perseverance for long-term goals." [...]
Kimberly wrote looking for help with a Hungarian rhyme. Here's the question she emailed us: Hi Lisa, I love your website because I spent three years teaching at a bilingual preschool in Budapest and I loved it! I remember one of the Hungarian teachers playing a game with the children that I [...]
Renee Dickens wrote to us asking for help with a childhood song: "My grandmother used to sing a Norwegian song or rhyme she called 'Ree Dee Dunkin'. No one in our family can find anything about it. It would be really great to have the actual song with all the words. Your help [...]
Comics are a great way to learn foreign languages! There's a dual language comic by LA Johnson on NPR about dual language learning for children. You can read it here. In addition to being interesting, the comic mentions "Eenie, Meenie Miney Moe" in Spanish. It's called, Tin [...]
Here's a tongue twister for you… it's simply, "Black bug's blood." Try to say it… it's harder than it seems… but it's fun! Here's an MP3 Recording of Black Bug's Blood. Thanks to Jason Pomerantz for the recording and to Lee [...]
Juneteenth celebrates June 19th, 1865, when it was announced in the U.S. that slavery was abolished in Texas and the Confederate South. Juneteenth is celebrated on the state level in 45 states. To celebrate, there are public readings of the Emancipation Proclamation. People also sing songs like [...]
"Ooey Gooey was a Worm" is a great poem for little kids to learn and recite. The words are as follows: Oooey gooey was a worm And a mighty worm was he He sat upon a railroad track And a train he did not see, Oooey Gooey! You can hear it recited in the video […] [...]
Lawrence Silverman sent us this email about the song, "Nuts in May" with the note, "I grew up (a long time ago) in the depths of rural England when many old customs now forgotten were still observed. I don't like to think of them being altogether forgotten. I'd be [...]
The moon is a wonderful topic for children. We can all remember the magic of watching the moon follow us on our way home at night. Below you can listen to the poem "The Kind Moon" by Sara Teasdale and read along with the text… MP3 Recording of The Kind Moon The Kind Moon by [...]
Over 125 songs and rhymes. Each includes the full text in Spanish, with translations into English. Many include links to recordings. Order Here!


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About the Model E221
Hermann Beyer has built a tradition and legacy of fine craftsmanship, meticulous shop adjusted standards, and a focus on value for the student musician. These instruments continue to display the high standards Heinrich Roth brought from Germany and remain the favorite of educators for their reliability, playability, sound and construction. Each Scherl & Roth instrument is Set-up & Ready!


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Korg has released iPolysix an iPad version of it's classic Polysix synthesizer. Unlike the original there is a step sequencer, drum machine, chordal mode, Soundcloud sharing and Kaoss type effects pads. About $15 USD.
"iPolysix is an analog polyphonic synthesizer that's been carefully designed to take full advantage of the 7.9-inch display of the new iPad mini as well as the iPad. Bringing together a sequencer, drum machine, and even a mixer, it transforms your iPad or iPad mini into the ultimate analog synth studio. Pack an amazing set of early-'80s analog equipment into your iPad, and time-travel back to the dawn of polyphonic synthesizers!" – Korg
For more info: korg.com/iPad_Apps


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Baby Play and Explore
Come enjoy an hour of unstructured play and social time for children (0-2 years old) and their caregivers. Enjoy books, music, and a variety of developmentally appropriate toys in our warm and inviting play space. This is a great opportunity to introduce your little one to the library, make new friends, and learn through play.


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Schapire, A.L., Bologna, N.G., Moro, B., Zhai, J., Meyers, B.C. and Palatnik, J.F.
Notes: The authors of this study present a method for genome-wide analysis of miRNA processing intermediates in plants. The method presented uses reverse transcription performed with a mix of primers designed against known miRNA precursors. The molecules are next amplified to generate a library for deep sequencing. Total RNA was isolated and purified from plant tissue and then treated with RQ1 RNase-Free DNase to remove contaminating DNA. Ribosomal RNA was selectively removed before adapter ligation and reverse transcription. cDNA libraries were prepared; PCR products from the libraries were separated on an agarose gel and purified using Wizard® SV Gel and PCR Clean-Up System prior to sequencing. (4561)
Expand Full Notes »
RQ1 RNase-Free DNase
Wizard® SV Gel and PCR Clean-Up System
Black, J.C., Manning, A.L., Van Rechem, C., Kim, J., Ladd, B., Cho, J., Pineda, C.M., Murphy, N., Daniels, D.L., Montagna, C., Lewis, P.W., Glass, K., Allis, C.D., Dyson, N.J., Getz, G. and Whetstine, J.R.
Notes: The HaloTag® protein tag was used in experiments to identify protein partners of KDM4A that involved in site-specific copy number gain in tumors, specifically at the 1q12h region. Expression constructs were transfected into HEK293T cells using the FuGENE® HD Transfection Reagent. The HaloTag-KDM4A (Cat.# FHC00602) and HaloTag-Suv39h1 (Cat.# FHC09879) expression constructs were obtained from the Kazusa DNA Research Institute (Kisarazu, Japan). Interacting proteins identified included DNA polymerase subunits and members of the minichromosome maintenance (MCM) complex. (4408)
pHTN HaloTag® CMV-neo Vector
HaloLink™ Resin
FuGENE® HD Transfection Reagent
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Ma, K., Conrad, R. and Lu, Y.
Notes: The authors of this study investigated the microbial mechanisms associated with the reduction of methane production and emission from rice fields observed with intermittent field drainage. They looked in particular at the abundance of mcrA gene copies and transcripts from rice paddy soil fauna. The mcrA gene encodes the alpha subunit of methyl coenzyme M reductase.
Total nucleic acid was extracted from soil samples using a phenol-chloroform procedure. For RNA analyses, DNA was hydrolyzed using RQ1 RNase-free DNase in the presence of 0.2µl Recombinant RNasin® Ribonuclease Inhibitor and then further purified using a commercial kit. cDNA synthesis was carried out using the Improm-II™ Reverse Transcription System, again in the presence of 1.0µl Recombinant RNasin® Ribonuclease Inhibitor. A clone library of transcripts was generated using the pGEM®-T Easy Vector System. The transcript standard for quantitative mcrA analysis was prepared from the in vitro transcript of a mcrA clone using the Riboprobe® in vitro Transcription Systems. (4241)
pGEM®-T Easy Vector System I
pGEM®-T Easy Vector System II
ImProm-II™ Reverse Transcription System
Recombinant RNasin® Ribonuclease Inhibitor
Riboprobe® System-SP6
Riboprobe® System-T3
Riboprobe® System-T7
Riboprobe® Combination System-T3/T7 RNA Polymerase
Riboprobe® Combination System-SP6/T7 RNA Polymerase
Chiluiza, D., Bargo, S., Callahan, R. and Rhoads, R.E.
Notes: RNA purified from polysome gradient fractions was treated with RQ1 RNase-Free DNase then inactivated by adding 2mM EGTA and heating the reaction to 65°C for 10 minutes. RQ1 RNase-Free DNase was also used to treat total RNA extracted from 3T3–3e5 cells. In both cases, the treated purified RNA was used for cDNA synthesis. (4186)
Dai, W., Zhang, G. and Makeyev, E.V.
Notes: The full-length 3´ UTR of mouse RNA-binding protein HuR was amplified and cloned into psiCHECK™-1 Vector to create pEM429 plasmid. To generate radiolabeled RNA substrates for use in cleavage assays, RNA was synthesized from 1µg of linearized plasmid using 50µCi of [α-32P]UTP, 0.8mM Ribo m7G Cap Analog and T7 RNA Polymerase by incubating for 1.5 hours at 37°C. The RNAs were then treated with 1 unit of RQ1 RNase-Free DNase per 1µg of template DNA for 15 minutes at 37°C before extracting with phenol:chloroform, precipitating with ethanol and resuspending in DEPC-treated water. The cleavage assay used 60fmol of 32P-labeled substrate RNA with 10U Recombinant RNAsin Ribonuclease Inhibitor in a reaction incubated for 2.5 hours at 30°C. RNA probes were labeled with biotin using T7 or T3 RNA Polymerases with a biotin-UTP labeling NTP mixture and incubated for 2 hours at 37°C. The biotinylation reaction was then treated with RQ1 RNase-Free DNase following the same protocol used for radiolabeled RNA. To form HuR/RNA complexes, 2µg of biotinylated RNA was mixed with 100µg nuclear extract and 40 units Recombinant RNAsin® Ribonuclease Inhibitor in a total volume of 20µl, and incubated for 30 minutes at room temperature. For CstF-64/RNA complexes, 1µg of biotinylated RNA was used and the complexes were stabilized by UV crosslinking using 10U Recombinant RNAsin Ribonuclease Inhibitor during the UV treatment. NIH 3T3 cells were UV crosslinked and either total or nuclear RNA used for immunoprecipitation. After extraction the RNAs were treated with RQ1 RNase-Free DNase for 15 minutes at 37°C before RT-PCR using HuR-specific primers. Total RNA purified from cultured cells were incubated with 50U/ml RQ1 RNase-Free DNase at 37°C for 30 minutes before use in RT-qPCR. (4187)
psiCHECK™-1 Vector
Ribo m7G Cap Analog
T7 RNA Polymerase
Yun, C.S., Suzuki, C., Naito, K., Takeda, T., Takahashi, Y., Sai, F., Terabayashi, T., Miyakoshi, M., Shintani, M., Nishida, H., Yamane, H. and Nojiri, H.
Notes: The authors investigated the expression of genes encoding histone-like (H-NS) proteins from the self-transmissible pCAR1 plasmid and Pseudomonas putida KT2440 genome, as well as the interaction of H-NS family members in vitro. Gene expression was quantified using quantitative RT-PCR and RNA templates that were treated with RQ1 RNase-Free DNase to degrade contaminating DNA. Interactions between Pmr and other H-NS proteins were monitored using pull-down assays. His-tagged Pmr was expressed in E. coli, purified and used as bait for FLAG-tagged H-NS family proteins. Protein purification of His-tagged proteins was performed using the MagneHis™ Protein Purification System. (4119)
MagneHis™ Protein Purification System
Slepenkin, A., Enquist, P.A., Hägglund, U., de la Maza, L.M., Elofsson, M. and Peterson, E.M.
Notes: The authors screened members of a class of acylated hydrazones of salicylaldehydes (INPs) to characterize their ability to inhibit growth of Chlamydia by affecting the type III secretion (T3S) system, a potent virulence mechanism. Expression levels of various T3S genes and gene markers of early, middle and late developmental cycles were examined by RT-PCR in Chlamydia trachomatis-infected HeLa 229 cells in the presence and absence of INPs. HeLa229 RNA was isolated at 4, 8, 24 and 36 hours postinfection, treated with RQ1 RNase-Free DNase and amplified using the Access RT-PCR System in the presence of 0.5 units of RNasin RNase Inhibitor. Each set of experiments included a no-reverse transcriptase control reaction to control for DNA contamination and a positive control reaction using the Positive Control RNA with Carrier and control primers supplied with the kit. (3795)
Access RT-PCR System
RNasin® Ribonuclease Inhibitor
Slot, K.A., Voorendt, M., de Boer-Brouwer, M., van Vugt, H.H. and Teerds, K.J.
Notes: The authors examined the locations and levels of apoptosis-related Fas, Fas ligand, Bcl-2, Bax and caspase-3 proteins in ovarian tissue throughout the rat estrus cycle. Protein levels were determined using Western blotting, and proteins were localized by immunhistochemistry. The presence of Fas, Fas ligand, Bcl-2, Bax and caspase-3 mRNA in various ovarian tissues was monitored by RT-PCR. Reverse transcription was performed using the ImProm-II™ Reverse Transcription System, 1µg of RQ1 RNase-free DNase-treated RNA and an oligo(dT) primer. One microliter of the reverse transcription reaction was amplified by PCR, and 10µl of the amplification products were analyzed by agarose gel electrophoresis. (3724)
Sang, Y., Ortega, M.T., Blecha, F., Prakash, O. and Melgarejo, T.
Notes: The investigators cloned three β-defensins, which are antimicrobial peptides, from canine testes. A canine expressed sequence tag (EST) was identified based on similarity to human β-defensins. Full-length cDNAs were obtained using 5´- and 3´RACE, then amplified by PCR and cloned into the pGEM®-T Easy Vector. cDNA sequences were confirmed using the SP6 and T7 Promoter Primers. The tissue-specific expression of canine β-defensins (cBDs) was characterized using the AccessQuick™ RT-PCR System to amplify β-defensin RNA from a variety of tissues. RNA was treated with RQ1 RNase-Free DNase prior to RT-PCR. The identity of the RT-PCR products was confirmed by electrophoresis, transfer to nylon membranes and hybridization to probes derived from sequence-confirmed β-defensin clones; the probes were synthesized using the Prime-a-Gene® Labeling System. To localize expression of the three β-defensin isoforms in canine testes, in situ hybridization (ISH) was performed. The 3´-RACE products were cloned into the pGEM®-T Vector, which was then linearized and treated with exonuclease III to delete an approximately 80-bp region shared by the three cBD isoforms. The resulting product was used to synthesize sense and antisense ISH probes. (3453)
AccessQuick™ RT-PCR System
pGEM®-T Vector System I
pGEM®-T Vector System II
Prime-a-Gene® Labeling System
SP6 Promoter Primer
Huck, L., Scherrer, A., Terzi, L., Johnson, A.E., Bernstein, H.D., Cusack, S., Weichenrieder O. and Strub, K.
Notes: RQ1 RNase-Free DNase was used to remove plasmid DNA template from in vitro transcription reactions. (3186)
Perron, K., Caille, O., Rossier, C., van Delden, C., Dumas, J.L., and Kohler, T.
Notes: Two genes (CzcR and CzcS) encoding the CzcCBA (cobalt/zinc/cadmium) heavy metal efflux pump were cloned using Pfu DNA Polymerase and genomic DNA from PT5 and PT1105 strains of Pseudomonas aeruginosa. The products were 900 and 1,600 bp, respectively. RNA from 5 different strains of Pseudomonas aeruginosa was isolated and treated with RQ1 RNase-Free DNase. The RNA was used in reverse transcription reactions with the ImProm-II™ Reverse Transcriptase and random primers. Copy-DNAs produced from the reaction were stored at -20°C until use in real-time PCR. (3044)
ImProm-II™ Reverse Transcriptase
Pfu DNA Polymerase
Random Primers
Grubor, B., Gallup, J.M., Meyerholz, D.K., Crouch, E.C., Evans, R.B., Brogden, K.A., Lehmkuhl, H.D. and Ackermann, M.R.
Notes: This paper describes the use of RQ1 RNase-Free DNase to remove DNA from TRIZOL- purified total RNA. The researchers describe stopping RQ1 RNase-Free DNase reactions with RQ1 RNase-Free DNase Stop Solution and heating the reactions at 64°C before using the samples in RT-PCR. (3187)
Pillitteri, L.J., Lovatt, C.J. and Walling, L.L.
Notes: The authors identified a TERMINAL FLOWER homolog, CsTFL, in Washington navel oranges (Citrus sinensis) and investigated its role and the role of other genes in juvenility and flower production. The CsTFL gene was amplified from genomic DNA using PCR and degenerate primers, and amplification products were cloned into the pGEM®-T Easy Vector. The resulting clones were sequenced using the fmol® DNA Cycle Sequencing System. The CsTFL cDNA was amplified by RT-PCR, using 4 µg of total RNA from whole flowers and ImProm-II™ Reverse Transcriptase. The amplified cDNA was then cloned into the pGEM®-T Easy Vector. To evaluate CsTFL gene copy number and allele origins, the authors performed a Southern blot with 10 µg of genomic DNA and a CsTFL probe labeled with the Prime-a-Gene® Labeling System. To characterize CsTFL expression in various citrus tissues, RT-PCR was performed with 2 µg of total RNA and ImProm-II™ Reverse Transcriptase. The levels of CsTFL RNA and other RNAs were determined by cDNA synthesis using ImProm-II™ Reverse Transcriptase, followed by real-time PCR. Amplification products were quantitated by SYBR® Green fluorescence. Standard curves for each real-time PCR target were generated using known amounts of in vitro transcribed RNA. Prior to reverse transcription and real-time PCR, total RNA samples were treated with RQ1 RNase-Free DNase to remove DNA contaminants. (3650)
Barends, S., Bink, H.H.J., van den Worm, S.H.E., Cornelis W.A. Pleij, C.W.A., and Kraal, B.
Notes: The Wheat Germ Extract was used to demonstrate that the 3' end of a viral mRNA acts as a tRNA-like structure (TLS). The tRNA-like structure was shown to accept a [H3]valine residue in the Wheat Germ Extract. The turnip yellow mosaic virus (TYMV) TLS structure was also shown to be able to function with ribosomes by donating [H3]valine in translation assays using Wheat Germ Extract with TYMV RNA but not BMV or AMV RNA. RNAs to be used as templates in the reactions were transcribed with the T7 RiboMAX™ Large Scale RNA Production System. After transcription DNA templates were removed with RQ1 RNase-Free DNase. (3386)
RiboMAX™ Large Scale RNA Production System-T7
Wheat Germ Extract
Kim, D.J., Boylan, B., George, N. and Forst, S.
Notes: The swarming behavior of the symbiotic-pathogenic bacterium Xenorhabdus nematophila is examined in this work. To investigate changes in gene expression in different strains at various times, the researchers utilized the AccessQuick™ RT-PCR System to measure the relative amount of gene product. To ensure that the assay was linear, different cycle numbers were used for each gene target ranging from 15 to 21 cycles of amplification. The RT-PCR used approximately 600ng of total RNA that was treated with RQ1 RNase-Free DNase before use. (2745)
Luparello, C., Sirchia, R. and Pupello, D.
Notes: Total and poly(A)+ RNA from treated and untreated 8701-BC breast cancer tumor cells were treated with RQ1 RNase-free DNase. The RNA samples were reverse transcribed using the M-MLV RNase H– point mutant reverse transcriptase and random primers to create cDNA used in downstream analyses. The cDNA from the reactions were used in PCR, differential display PCR, and semi-quantitative multiplex PCR reactions. In differential display PCR studies, the authors analyzed differentially displayed bands by staining 6% polyacrylamide gels with the SILVER SEQUENCE™ Staining Reagents. Differentially displayed bands were re-amplified and cloned using the pGEM®-T Easy Vector and high efficiency JM109 competent cells. (3020)
JM109 Competent Cells, >108cfu/μg
M-MLV Reverse Transcriptase, RNase H Minus, Point Mutant
SILVER SEQUENCE™ Staining Reagents
Wascher, R.A., Huynh, K.T., Giuliano, A.E., Hansen, N.M., Singer, F.R., Elashoff, D., Hoon, D.S.B.
Notes: Total cellular RNA was isolated from peripheral blood leukocytes, mononuclear cells, tumor specimens, and breast cancer cell lines. Purified RNA was treated with RQ1 RNase-Free DNase. (2652)
Rees, D.A., Lewis, M.D., Lewis, B.M., Smith, P.J., Scanlon, M.F., and Ham, J.
Notes: Promega's CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay was used to examine the effects of adenosine and adenosine receptor agonists on a pituitary folliculostellate cell line and two pituitary endocrine cell lines. The authors also used RQ1 RNase-free DNase during the course of their experiments. (2495)
CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay
Åkerud, P., Holm, P.C., Castelo-Branco, G., Sousa, K., Rodriguez, F.J., and Arenas, E.
Notes: Total RNA was isolated from E15, E19, P0, P4 and adult rat brain tissue. RNA was treated with RQ1 RNase-free DNase prior to RT-PCR experiments. (2587)
Xie, M., He, Y. and Gan, S.
Notes: In this paper, extracted total RNA was treated with RQ1 RNase-Free DNase prior to RT-PCR analysis. (2365)
Lee, S. , Wevrick, R.
Notes: Total RNA was treated with RQ1 RNase-Free DNase prior to RT-PCR. (0816)
Learish, R.D., Bruss, M.D., and Haak-Frendscho, M.
Notes: A primary cell line from rat subventricular zone which remains undifferentiated over time was developed as a model for MAPK activation. Cell were stimulated with 20 ng/ml bFGF and 20 ng/ml EGF (Promega) to activate MAPK. The MAPK pathway was inhibited with either U0126 (Promega) or PD98059. Immunocytochemistry was performed with the Anti-ERK 1/2 pAb (1:100 dilution) to detect both active and inactive forms of MAPK proteins and with the Anti-ACTIVE™ MAPK pAb (1:100 dilution) to specifically detect the dually phosphorylated, active forms of MAPK. Cells were also immunostained with the neuron specific marker Anti-III-tubulin mAb (0.5 µg/ml). Cell proliferation was monitored with the CellTiter 96® AQueous One Solution Cell Proliferation Assay System. Apoptosis within the cell population was monitored using the DeadEnd™ Fluorometric TUNEL System. (2391)
Anti-ACTIVE® MAPK pAb, Rabbit, (pTEpY)
Anti-βIII Tubulin mAb
CellTiter 96® AQueous One Solution Cell Proliferation Assay
DeadEnd™ Fluorometric TUNEL System
MEK Inhibitor U0126
Stallmeyer, B., Drugeon, G., Reiss, J. , Haenni, A. L., Mendel, R. R.
Notes: RNasin® Ribonuclease Inhibitor was used in a in vitro transcription reaction to produce capped transcripts. The template DNA was then removed by RQ1 RNase-free DNase. (0328)
Sinz, E.H., Kochanek, P.M., Dixon, C.E., Clark, R.S.B., Carcillo, J.A., Schiding, J.K., Chen, M., Wisniewski, S.R., Carlos, T.M., Williams, D., DeKosky, S.T., Watkins, S.C., Marion, D.W., Billiar, T.R.
Notes: Genomic DNA was isolated from mouse brain with the Wizard® Genomic DNA Purification Kit. The isolated DNA was used for PCR. The RNasin® Ribonuclease Inhibitor was used to protect RNA in RT-PCR. (0372)
Wizard® Genomic DNA Purification Kit
Liu, J., Tzou, P., Hill, R.J., Sternberg, P.W.
Notes: Before RT-PCR reactions, the RNA template was treated with RQ1 RNase-free DNase. (0776)


text:
So, I had some changes to my bag recently. I am still not 100% happy with it though, there are some things missing. I try to have a understable, a stable and a overstable disc of all cathegories ( putter,midrange, fairway driver, highspeed driver ), but I am missing some discs. Here is my bag :
Putters :
Understable : Pure
stable : beat in Aviar <-- I want something out of the box here. Tried challengers and they look pretty close to what I want. Open to suggestions
overstable : new Aviar
Midranges : ( I am totaly happy with my midranges. No need to comment here. )
Understable : comet
stable : buzzz
overstable : Wasp
Faiway drivers :
Understable : Leopard
stable : <-- ?
overstable : <-- ?
Big gun drivers : ( Nothing to add here, I am very happy with what I have ).
Understable : Nuke
stable : Destroyer
overstable : Boss
Discs that I dont carry any more since I postet my bag the last time :
- Orion LS
- Avenger
- Valkyrie
Fairway drivers : I am fairly new to these discs, I still have a feeling that they have some overlap with my midranges, I can throw my buzzz 330 and my comet 350. But I baught some Leopards for technique exercises and liked them so much that they now have a spot in my bag. From what I have read, the Eagle and the Teebird are among the favourites for stable to overstable fairway drivers. Keep in mind, I like to play discs out of the box and in premium plastic. Please dont comment that I should get a Teebird and beat it in. I can do pretty much any shot with my Leopard except for maybe a wide S shot, so I am in no rush to get overstable fairway drivers. But it would be nice to have.


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As soon as we saw Kate Hudson in her super-cute Chanel dress at the Tom Ford dinner last night, we knew we had already fallen in love with it — back when Rachel Bilson wore it to a Chanel dinner in L.A. in January. We think that both women look sweet and sophisticated in their bow and chain-laden frock — and we can't possibly decide who we like it better on. But we know you can! Tell us: who wears their Chanel dress better? Rachel or Kate?
Click here to see more photos, news and a full bio of Kate Hudson and Rachel Bilson.
Photo: Frazer Harrison/Getty; Stephen Lovekin/WireImage


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Gwen Stefani's Style Evolution
In the fountain at Five Hotel.
For this year's belle du Cannes, Toronto's Sarah Gadon, the festival wasn't all flashbulbs, cocktail parties, and cruises on George Clooney's yacht. For the star of two of the buzziest films at the fest (David Cronenberg's Cosmopolis, fronted by Robert Pattinson, and the smaller Antiviral, directed by Brandon Cronenberg, David's son), it was a lot of work and preparation. A film student at the University of Toronto, Gadon takes an academic approach to choosing parts. Her breakout role: the wife of Michael Fassbender's Carl Jung in A Dangerous Method. From the set of her next film, An Enemy, costarring Jake Gyllenhaal, the 25-year-old reflects on her big Côte d'Azur debut.
When you found out you were invited to Cannes, was your first thought, What am I going to wear?
My first thoughts were, Where am I going to stay? How will I get there? These festivals seem so glamorous from the outside looking in, but there are a lot of first-time directors and actors just trying to get exposed to the rest of the world. So those are the big questions.
OK, but then you thought about what to wear, right?
I was lucky to have been to the Venice Film Festival the year before. It was good practice for Cannes. I learned to look to people to help me get through the experience. Jason Wu was really wonderful. He made me a custom dress for the premiere of Cosmopolis. And Fendi took me under its wing and helped with looks and handbags. It's essential to look good.
Any starstruck moments?
Of course! I saw Robert De Niro, Terry Gilliam, and Oliver Stone. It's mostly directors whom I get starstruck around. You can have a bunch of great actors in a film, but if you don't have anyone telling a great story, it's a moot point.
Did you get to bring a date for the week?
My mom came with me. Cannes is so intense and crazy that at the end of the night, it's good to be able to locate your mom and say, "I can't believe this just happened!"
Cannes is: "[A film festival] on steroids. It's a festival for everything–the industry, the fans, the brands, the actors."
Glam moment: "I borrowed some Chanel–they were some of the most elegant dresses I've ever worn."
Casting Project Runway


text: Sometimes bad guys make the best good guys. In the LEVERAGE Roleplaying Game, you create a Crew of ex-cons, thieves, and hustlers who use their skills to take down the mob bosses, corporate sharks, and political thugs that bring grief to the innocent. Based on the hit TNT show and powered by the Cortex Plus system, this is the caper game you've been waiting for!


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Randomised Trial of Structured Treatment Interruption of HAART in HIV-Infected Adults in Abidjan (ANRS 1269 TRIVACAN)
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|HIV Infections
|Procedure: Structured Treatment Interruption Drug: Zidovudine (ZDV) Drug: Lamivudine (3TC) Drug: Efavirenz (EFV) Drug: Ritonavir (NRV) Drug: Indinavir (IDV)
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Multicentric Randomised Controlled Trial Assessing the Efficacy of Two Strategies of Structured Treatment Interruption of Highly Active Antiretroviral Therapy (HAART) Compared With a Continuous HAART in HIV- Infected Adults in Abidjan
- To assess the non-inferiority at 24 months of two STI strategies of HAART compared with a continuous HAART in terms of :
- Percentage of patients with CD4 count over 350 per mm3
- Incidence of severe morbidity
- Incidence of mortality
- To compare at 24 months two STI strategies of HAART with a continuous HAART in terms of :
- HIV resistance to antiretroviral drugs
- Cost-utility
- Compliance to treatment
|Study Start Date:
|December 2002
|Study Completion Date:
|December 2006
The objective of this study is to assess the non-inferiority of two strategies of structured treatment interruption (STI) of highly active antiretroviral treatment (HAART) compared with a continuous HAART.
It's a multicentric open labeled randomised non-inferiority trial, which takes place in 5 health care centres in Abidjan, the economic capital city of Cote d'Ivoire
The trial was designed in two phases :
Pre-randomisation phase : 840 HAART-naive HIV-infected adults start the following continuous HAART regimen: zidovudine-lamivudine in combination with
- preferably efavirenz, for HIV-1 infected men, and HIV-1 infected women with an effective contraception and no history of nevirapine-containing p-MTCT (prevention of mother to child transmission);
- ritonavir-indinavir, for HIV-2 infected patients, women not desiring contraception, and women with a past history of p-MTCT with nevirapine.
Trial phase : After at least six months on continuous HAART in the pre-randomisation phase, patients who meet success criteria (CD4 count over 350/mm3, undetectable viral load, absence of current opportunistic infection) are randomised into three arms :
- Arm 1: Continuous HAART (1 of 6 patients)
- Arm 2: Fixed STI strategy (3 of 6 patients): immutable periods of 2 months on HAART / 4 months off HAART
- Arm 3: CD4-guided STI strategy (2 of 6 patients): unlimited interruption of HAART, and then re-introduction/re-interruption guided by the evolution of the CD4 count.
Following the DSMB recommendation, the arm 3 has been discontinued in october 2005. The trial is continuing for patients in the arms 1 and 2.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Informed consent
- 18 years old or more
- CD4 count between 150 and 350 per mm3 (or CD4 percentage between 12.5 and 20 percent)
- no past history of curative antiretroviral therapy
- residence in Abidjan
Exclusion Criteria:
- pregnancy
- severe renal failure
- severe hepatic failure
- severe neuropsychiatric disease
Please refer to this study by its ClinicalTrials.gov identifier: NCT00158405
|Côte D'Ivoire
|Centre de Prise en Charge et de Formation ACONDA
|Abidjan, Côte D'Ivoire
|Centre de Suivi des donneurs de sang, Centre National de Transfusion Sanguine
|Abidjan, Côte D'Ivoire
|Centre Intégré de Recherches Biocliniques d'Abidjan
|Abidjan, Côte D'Ivoire
|Service des Maladies Infectieuses et Tropicales, CHU de Treichville
|Abidjan, Côte D'Ivoire
|Unité de Soins Ambulatoires et de Conseil, CHU de Treichville
|Abidjan, Côte D'Ivoire
|Study Director:
|Xavier Anglaret, MD
|Unité INSERM 593, Université Victor Segalen Bordeaux 2
|Principal Investigator:
|Christine Danel, MD
|Programme PACCI, Abidjan
|Study Chair:
|Roger Salamon, Pr
|Unité INSERM 593, Université Victor Segalen Bordeaux 2
|Study Chair:
|Emmanuel Bissagnene, Pr
|CHU Treichville
|ClinicalTrials.gov Identifier:
|NCT00158405 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 7, 2005
|Last Updated:
|December 29, 2008
Keywords provided by French National Agency for Research on AIDS and Viral Hepatitis:
Structured treatment interruption
Sub-saharian africa
Treatment Interruption
Treatment Naive
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors
Cytochrome P-450 CYP2B6 Inducers
ClinicalTrials.gov processed this record on September 25, 2017


text:
Two-balls-in-one means pure delight for your ball-loving dog! This interactive, puzzling dog toy rolls unpredictably and invites your dog to try to remove the center ball from the larger outer ball. But try as he might, your dog won't be able to remove the inner ball from Paw-zzle Balls' 5 just-too-small holes. The Paw-zzle Ball is sure to keep your dog on his toes!
Both 4.5" dia and 6" dia Paw-zzle Balls hold a hard plastic inner ball. The 10" dia Paw-zzle Ball holds a soft, textured vinyl ball that includes a 5/8" dia hole perfect for inserting treats to make playtime even MORE rewarding. Paw-zzle Balls feature nontoxic plastic construction that will not tear, break, or burst. Paw-zzle Balls come in assorted colors.
Shop all Dog Toys.
Please click on "More Information" for playtime recommendations.


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Founded in 1829 by a German national and two Frenchmen, the Bollinger Champagne house, located in Ay, has been producing Pinot based wines for almost two centuries. In that time, Bollinger has accumulated quite a following, lead by its neighbors across the English Channel. When he's not drinking his favorite vodka martini -- shaken, not stirred -- James Bond has been known to request a bottle of Bollinger. However, Bond isn't the only Brit with a weakness for Bolly; Queen Victoria issued a royal warrant in 1884 making Bollinger the official supplier to the court. Today, often referred to as the 'British style' of Champagne is full-bodied powerful and rich more appropriate at the dinner table than as an aperitif and dominated by Pinot Noir. The house's basic Special Cuvee which is typically austere on release features mature notes of toffee and toasted bread due to the fact that a portion of the wine is fermented in cask and to the inclusion of older reserve wines in the blend. It typically contains 60% Pinot Noir 25% Chardonnay and 15% Pinot Meunier. In the best vintages a portion of the Grande Annee is set aside for later disgorgement and released as R.D.for 'recently disgorged'. The prestige cuvee however is Vieille Vignes Francaises produced from low yielding vines in Clos-St. Jacques and Chaudes Terres. This extraordinarily rich wine is made from Pinot Noir Pinot Meunier or a blend of the two. Only 3-5000 individually numbered bottles of Vieille Vignes Francaises are produced each year.
Champagne-making is the highly refined art of blending base wines into a whole that is greater than the sum of its parts. These component wines come from different grape varieties (the white grape Chardonnay and the red varieties Pinot Noir and Pinot Meunier) and from different villages and vineyards. And because only four or five harvests per decade in this marginal climate northeast of Paris provide the raw materials to make balanced, complete Champagne wines--that is, vintage-designated Champagnes, which must be entirely from the year indicated on the label--most Champagnes also combine juice from two or more vintages.
Blending across vintages is the way Champagne producers are able to maintain the house styles their customers have come to expect. As nonvintage wine accounts for about four-fifths of total Champagne production, it is hardly surprisingly that the reputations of most major houses hinge on the quality and consistency of their non-vintage blends. Not only that, but the better nonvintage Champagnes on the market today are often every bit as satisfying as the typical vintage bottling--and a lot cheaper to boot.
Two districts of Champagne are considered best for high-quality grapes: the Cote des Blancs, whose chalk and limestone soils are ideal for Chardonnay, and the Montagne de Reims, which is ideally situated for growing the red grapes Pinot Noir and Pinot Meunier. The Vallee de la Marne, which stretches in a narrow band across most of the region and is planted to both red and white grapes, is the largest area aside from the Aube district, which lies far to the south, disconnected from the other Champagne vineyards by almost 50 miles and generally producing fruit destined for anonymous blends.
France is the fountainhead of the grape varieties most craved by North American wine drinkers: Cabernet Sauvignon, Merlot, Pinot Noir, Syrah, Chardonnay, and Sauvignon Blanc. In fact, these grapes are widely referred to as "international" varieties because they have been planted and imitated all over the world. Of course, one of the most exciting developments in wine over the past generation has been the growth of intriguing local styles of these varieties, such as Pinot Noir in Oregon and New Zealand, or Syrah in Australia, South Africa, and California. But most cosmopolitan wine-lovers -- and even winemakers -- would agree that French wines are the archetypes.
France enjoys the perfect geographic position for the production of a wide range of fine wines. Its relatively northerly location ensures long hours of daylight during the summer months and an extended growing season, allowing for the slow and steady accumulation of flavor in the grapes. Although the country as a whole enjoys a temperate climate, conditions can vary significantly within a limited land mass: cool and Atlantic-influenced; continental, with very cold winters and hot summers; warm and Mediterranean, with wet winters and dry summers.
Wines of France
France began classifying its best French wine-producing sites more than 200 years ago. Its detailed appellation controlee system, designed in the 1930s, has served as the model for classification systems adopted by other countries in Europe and elsewhere. Appellation d'Origine Controlee (often abbreviated to AOC), means "controlled place name" and is the consumer's assurance of the origin and authenticity of any French wine whose label bears these words.
AOC laws, administered by France's INAO (Institut National des Appellations d'Origine), establish the geographic limits of each appellation, permissable grape varieties and methods of production, minimum alcohol level, and maximum crop level (or yield) per hectare. Just beneath the highest category of appellation controlee is the comparatively tiny category of VDQS (Vins Delimites de Qualite Superieure), wines which may eventually be promoted to AC status and which are most commonly found in the Loire Valley and the Southwest. The third category is Vins de Pays, or "country wines". This latter category gives producers, including some of the more adventurous French wine growers, an escape route from the straitjacket of AC regulation in terms of higher permitted yields and less restrictive geography, a wider range of legal grape varieties, and fewer restrictions as to method of production and minimum age of vines. Finally, at the bottom of the pyramid, there are Vins de Table, or simple "table wines."
And yet, despite France's illustrious wine history and the fact that it is still the world's leading producer of wine, the country is struggling to compete in the international market. Today, France faces fierce competition from New World wine producers. U.S. imports of French wines actually declined, in number ofcases, between the end of 2002 and early 2006 -- this during a period when overall wine consumption in the U.S. grew by more than 50 percent.
Today, the French government is agonizing over how to help French wine producers, who are also facing homegrown challenges such as changing domestic drinking habits and an aggressive anti-alcohol abuse program. Wine producers in some regions of France are coming to view the AC system itself as an obstacle to selling wines to North America and other important export markets. Among the changes being considered are loosening restrictions on what can be planted where and on how wines can be made, and allowing producers in certain areas to indicate the grape variety or varieties on their labels -- rather than simply the place name, which is less meaningful to consumers in many of France's key export markets.
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Grace Muth turned 101 on Monday, Oct. 22, and and her niece Virginia,right, friends and the staff at Haven Hospice of the Tri-Counties Care Center celebrated with cake, gifts and lots of fun. Miss Grace received a special angel bear to watch over her when she sleeps, sleepwear and polka-dot slippers. By the time she finished opening gifts, Miss Grace declared she was ready for a slice of chocolate cake.
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Lick-the-Strip is a drinking game built upon the founding principles of truth-or-dare. This game is most successful when all players are wasted. Using a random number generator (6-sided die, numeric spin wheel, etc.) the player calls out a playable number, opponents name, and a dare. The roller "wins" his round if the number he calls corresponds to the number "rolled". If the number is not called correctly, it is the next player's turn. An example for Player 1 would be: "If I roll a 4, Jude has to lick the dirty strip on the living room table!". If Player 1 successfully calls and rolls a 4, then Jude must perform the dare given. If any players refuse to perform their dare, they must suffer a pre-determined consequence. An example would be to have the biggest player punch the Jude (or whatever player is pussing out) in the nuts. As the game progresses and the dares become more disgusting/harder to accomplish, the pre-determined consequence will keep players from leaving the game. Majority rules when determining what actions are deemed appropriate for the game. The game continues until all remaining players mutually decide to end the game.
"Who wants to get wasted and play Lick-the-Strip!?"
"Lick-the-Strip is the best game ever!"
"My testicles still hurt from playing Lick-the-Strip last night."
"Lick-the-Strip is the best game ever!"
"My testicles still hurt from playing Lick-the-Strip last night."
by Merikude January 03, 2013
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text:
Since their inception, implementing an enterprise resource planning (ERP) system has been an ambitious undertaking. Costing potentially multiple millions of dollars to install, companies want to leverage their automated ERP software—designed to link functions such as accounting, inventory control and human resources across an entire company—to do as much as possible. But when it comes to indirect taxes, is it possible to rely on an ERP system alone to achieve full compliance?
It's more difficult than one may think. The expansive indirect tax market landscape (also known as transaction tax, sales and use tax, value-added tax (VAT) compliance) is undergoing a regulatory evolution. In 2013, there were more than 350 rule changes that affected value-added taxes and goods and services taxes worldwide. More changes, including the controversial new 2015 VAT rules which will apply to telecom and cable company customers throughout the European Union, are on the way. These complexities create a host of potential pitfalls, and as a result, more tax, information technology and finance resources are needed to support the process.
Relying primarily on an ERP solution to manage indirect tax will not necessarily result in your objective of saving time and money as you manage indirect taxes, or in reaching higher levels of accuracy. In fact, companies that exclusively use automated ERP systems to track their indirect tax processes spend significant resources complying with local tax laws to ensure they calculate the correct amount of tax for each of their foreign operations. That's because an ERP system generally only provides basic tax determination capability. While it may be configurable, this can result in costly IT expenses and creates a process where the tax department loses control and visibility into the tax policy being established.
Another shortfall is that the ERP systems generally do not provide ongoing tax content, leaving the ever-changing tax rates, tax calculation logic and item taxability in the hands of the corporate tax department to attempt to manage. Also, although configurable tax code-based reporting can be possible within an ERP system which may be extended to provide box-level tax return reporting, the ERP systems fall short and are limited when it comes to the more complicated task of determining and calculating tax on certain types of taxes or complying with certain regulations. As a result, many companies struggle while trying to find other means to deal with complex and frequently-changing tax rules and rates, regulatory variances in other countries, or rules that are independent from ERP software.
So if complete automation is out with an ERP system, what is the answer? For an increasing amount of companies, it's a hybrid approach. By melding the best of the ERP systems with the best of a focused indirect tax solution, many companies are finding ways to reduce cost, complexity and risk around indirect tax.
Take Lenovo, for example. As one of the world's largest personal computer manufacturers with businesses all over the globe, Lenovo is subject to some of the most complex tax structures. An ERP solution alone would not allow Lenovo to account for the various regulatory deviations around the world, so the company turned to a hybrid approach that combined the flexibility and scalability of an ERP system with the domain-specific expertise from a specialized indirect tax solution. This helped Lenovo understand the overall impact of new configurations, guaranteed data integrity, and accurately determined their tax and compliance responsibilities in various countries. As a result, they were able to consolidate their indirect tax compliance processes into a single interface without missing any nuance. This ensured that all tax decisions were timely and accurate.
This streamlined approach allowed tax decisions to be made at the time of a transaction, and ensured that accurate data was used for both the determination and compliance process. It also provided the ability to maintain data for more than 1,500 global tax codes with minimal IT resources.
In a constantly-changing global marketplace, leaning on an ERP system alone to handle indirect taxes is just not enough. While it may seem like the simplest answer, the reality is that there are "no one size-fits all" solutions to today's complex indirect tax challenges. Today, a truly global solution will use existing ERP technology, coupled with specialized tax solutions to improve performance and protect a firm from unwanted risk.


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Tim Tebow's chances of getting picked up by another team are being damaged significantly by his own popularity, Yahoo! Sports' Michael Silver concluded after interviews with unnamed NFL head coaches.
NFL teams don't want the Tebowmania-related distractions that would surely follow if he were signed, the coaches told Yahoo!
"He seems like a great guy to have on a team, and I'd be tempted to bring him in as our backup," one NFC head coach said. "But it's just not worth dealing with all the stuff that comes with it."
An AFC head coach said, "You don't want to put up with the circus."
MORE: Tebow, the high school years
MORE: Jags fans say no to Tebow
Considering the dearth of quality backups in the league and that Tebow put up a 7-4 record as a starter with the Broncos in 2011, it would seem odd if he can't find a backup opportunity. As an example, take a look at the Rams' backup quarterback situation. The No. 2 on the depth chart is somebody named Austin Davis, an undrafted second-year player.
The AFC coach criticized the Jets for bringing in Tebow without an apparent plan to use his abilities as a running quarterback.
"I don't understand what the Jets did," the AFC coach says. "You have to have a plan for him, but they had no idea what they were doing. I do think they were shocked how bad he looked in practice and in the preseason … how bad his accuracy was. But why make the trade for the guy if you're not clear on how to use his abilities?"
The Yahoo! report said it is very unlikely Tebow will land with the Patriots, whose offensive coordinator, Josh McDaniels, was behind the Broncos' decision to draft Tebow. Silver said a Patriots "organizational source" told him coach Bill Belichick "hates" Tebow as a player and that the Patriots "wouldn't like the circus" that would come with Tebow's arrival.