text:
Drivers want technology that helps them improve their car's gas mileage as well as improving smartphone connectivity in their next cars, according to the 2013 U.S. Automotive Emerging Technologies Study from J.D. Power and Associates.
The study, which measures car owners' interest and purchase intentions for new car technologies, found that drivers were most interested in technology that easily links their smartphones to their cars, with 79 percent citing an interest before pricing was discussed, dropping to 67 percent when those surveyed learned of the $250 estimated cost for such technology.
J.D. Power and Associates said smartphone owners believe their devices should connect easily to their cars, and that owners often keep their cars for five years or more yet change smartphones more frequently, causing compatibility issues.
Two fuel-related technologies came in at second and third in the study, with 79 percent of drivers most interested in a fuel-economy indicator, which provides instant feedback on how to adjust a person's driving style to improve fuel economy, before they learned of the $50 price tag. That dropped only slightly to 72 percent after they were told the added cost. In addition, 76 percent of those surveyed were interested in active shutter grille vents, which are actual shutters in the grille that close to improve aerodynamics, thereby improving fuel economy. That number dropped to 61 percent when they were told it would cost $150.
The 2013 U.S. Automotive Emerging Technologies Study, which was fielded in March 2013, used responses from 16,758 car owners, who were asked questions about 22 emerging technologies, each with related secondary technologies.
Are you willing to pay more for new car technology? How much more? Is there a price point where you wouldn't?
Tara Baukus Mello writes the cars blog as well as the weekly Driving for Dollars column, providing both practical financial advice for consumers as well as insight into the latest developments in the automotive world. Follow her on Facebook here or on Twitter @SheDrives.


text:
In the days preceding Friday's commission hearing, which featured a written apology by Moss and a decision by Commission members Tom Hardin and Wendy Stein to dismiss the case without deciding whether the policy had been violated or not, attorneys for Moss and the Commission exchanged e-mails on a matter central to the case:
Did Hardin himself have a conflict of interest that should have kept him from voting on the alleged conflict created by Moss' phone call to Sheriff Ken fries following a June traffic stop?
The argument put forth by Moss' attorney, former City Councilman Tim Pape, was this: In Hardin's role as an assistant Allen County attorney, he is paid more than $36,000 to handle a variety of legal matters that at times have involved County Council. In an e-mail to Commission attorney Tim McCaulay, Pape noted that as a member of Council Moss has authority over the budget and "has over the years consistently and at times insistently questioned the spending upon county attorneys. Now (Hardin) is sitting in judgment of (Moss)."
McCaulay, however, responded that neither he nor Hardin believed recusal was necessary because Hardin had not done work for the Council since 2007, was not hired as attorney by the Council and is not subject to the ethics ordinance because he is also bound by legal codes of conduct.
The county's code exempts employees covered by other policies, which is why it had previously dismissed former county employee Phil Pease's complaint against Fries, who is subject to Indiana Sheriff's Association guidelines.
"I don't believe (Hardin) had a vendetta against me, but I've argued all along that the County Council attorney shouldn't have been sitting in judgment of me," Moss said.
Of course, If Hardin had recused himself, the case against Moss might still be going on more than six months after a county officer pulled him over on Dupont Road. Moss said he had left home early that morning to pick up his daughter and several friends who had been at a bar and did not want to drive home. Moss said he may have been pulled over because he had swerved while texting, but denied having anything to drink. He refused a field sobriety test but said he called Fries only to expedite a trip downtown for a more reliable test.
Did Pape's conflict-of-interest allegation influence Hardin's willingness to dismiss the case without a formal resolution in exchange for an apology, which Moss said was included in a statement issued months ago? Hardin was unavailable for comment, but I suspect not. I have no reason to believe Hardin was motivated by anything but his desire for public accountability and disclosure.
But that's precisely the trouble with conflicts of interest: As Moss' statement last week acknowledged, even the appearance of a conflict can undermine the public's confidence in public officials and the decisions they make.
County Commissioner Nelson Peters, who wrote the ethics ordinance in 2005, said Hardin and fellow Commission member Wendy Stein have suggested that changes in the bill may be needed. They're right. The process should be expedited (without calling the sheriff!), authority over elected officials should be clarified and members of the Commission should have no ties to county government. Even so, Peters said the ordinance's central mission was largely accomplished in this case.
"The intent was transparency; so officials would be beyond reproach." With a private legal bill of $10,000, certainly no one can argue Moss' case was swept under the rug.
But here's the irony: The Coliseum's offer of up to four tickets to "Batman Live" (provided by the show itself) costing up to $49.50 each does not necessarily violate the ordinance, said Chief Operations Officer Garnett Miller. The ordinance simply requires employees receiving gifts worth $25 or more to report the gift to the Commissioners' office. Several officials – many of whom have control over operations at the county-owned Coliseum — have already accepted the passes.
It's a non-transferable offer, by the way, meaning you'll have to pay for your tickets.
Holy handout, Batman! Can't we do better than this?

subset: commoncrawl


text:
A Phase 2a Study to Evaluate the Effect of Rilapladib (SB-659032) in Alzheimer's Disease
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: September 1, 2011
Last updated: April 27, 2015
Last verified: August 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The study is designed to investigate the effects of rilapladib on biomarkers related to the Alzheimer's disease, and cognitive function.
|Alzheimer's Disease
|Drug: 250mg rilapladib Drug: placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Phase 2a Study to Evaluate the Effect of Rilapladib (SB-659032) on Biomarkers Related to the Pathogenesis and Progression of Alzheimer's Disease
Resource links provided by NLM:
Genetics Home Reference related topics: Alzheimer disease
MedlinePlus related topics: Alzheimer's DiseaseU.S. FDA Resources
Further study details as provided by GlaxoSmithKline:
Primary Outcome Measures:
- Change from baseline in CSF Abeta42, Abeta40, Abeta42/ Abeta40 ratio [ Time Frame: Week 24 ]Efficacy
- Change from baseline in CSF tau and P-tau [ Time Frame: Week 24 ]Efficacy
- Change from baseline in working memory/executive function composite score [ Time Frame: Week 24 ]Efficacy
Secondary Outcome Measures:
- Change from baseline in CSF albumin quotient [ Time Frame: Week 24 ]Efficacy
- Change from baseline in plasma Abeta levels (Abeta42, Abeta40 and Abeta42/Abeta40 ratio) [ Time Frame: Week 24 ]Efficacy
- Change from baseline in CSF and plasma Lp-PLA2 activity [ Time Frame: Week 24 ]Efficacy
- Change from baseline in other aspects of cognition, including attention, episodic memory and an overall composite score [ Time Frame: Week 24 ]Efficacy
- Assessment of safety and tolerability of rilapladib in subjects with Alzheimer's disease over a 24 week treatment period, including AEs, vital signs, clinical labs [ Time Frame: Week 24 ]Safety
- Assessment of plasma concentrations of rilapladib and its active metabolite in plasma and CSF [ Time Frame: Week 24 ]Pharmacokinetics
|Study Start Date:
|October 2011
|Study Completion Date:
|February 2013
|Primary Completion Date:
|February 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 250mg rilapladib
Experimental drug
Drug: 250mg rilapladib
Experimental Drug
Placebo Comparator: placebo
Placebo comparator
Drug: placebo
Placebo comparator
Detailed Description:
The study is in subjects with Alzheimer's disease and evidence of cerebrovascular disease (CVD) who are currently treated with an acetylcholinesterase inhibitor (AChEI) and/or memantine. The study is a randomized, double-blind, placebo controlled, parallel group, repeat dose design, in which subjects (up to 60 randomized subjects per arm) will receive oral placebo or rilapladib (250 mg), once daily for 24 weeks in addition to their stable background AD therapy consisting of an acetylcholinesterase inhibitor (AChEI) and/or memantine. Subjects will take 250mg of rilapladib or placebo once daily for a period of 24 weeks. The total duration of participation for each subject will be approximately 30 weeks comprising approximately 4 weeks screening, 24 weeks treatment and 2 weeks follow-up. From the time of randomization and throughout the treatment period subjects will attend visits after 1 week, 4 weeks and thereafter every 4 weeks until Week 24. A follow-up visit will occur approximately 2 weeks after the final dose of study medication. Cognitive assessments will be performed at the screening visit, at the randomization (baseline) visit and at weeks 12 and 24 of the treatment period. Cerebrospinal fluid (CSF) samples will be taken via lumbar puncture at baseline and Week 24 for biomarker analyses related to Alzheimer's disease. Blood samples will be collected throughout the study for pharmacokinetics and a range of biomarker analyses. A range of safety and tolerability assessments will also be performed (including vital signs, laboratory tests, eye examinations and ECGs).
|Ages Eligible for Study:
|50 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- A clinical diagnosis of possible Alzheimer's disease in accordance with the National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria, with radiological (Magnetic Resonance Imaging [MRI] or Computed Tomography [CT]) evidence of significant cerebrovascular disease (CVD), assessed within the last 12 months
- Male or female between 50 and 80 years of age inclusive, at the time of signing the informed consent.
- Subject has a documented history of at least 6 months of ongoing Alzheimer's disease therapy (AChEIs and/or memantine) with stable dosing for at least the last 2 months (and with no intent to change for the duration of the study).
- Mini-Mental Status Examination (MMSE) score between 20 and 26 at Screening.
- Clinical Dementia Rating Scale (CDR) score of 0.5 or 1.0 at Screening.
- A female subject is eligible to participate if she is of non-childbearing potential defined as pre-menopausal females with a documented tubal ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous amenorrhea; or of child-bearing potential and agrees to use acceptable contraception methods
- Subject has provided full written informed consent prior to the performance of any protocol-specified procedure; or if the subject is unable to provide informed consent due to cognitive status, the subject will provide assent and full written informed consent will be provided by a legally acceptable representative
- The subject has a dedicated caregiver who is willing to supervise participation in the study
- In the opinion of the investigator, the subject has the ability to comply with study procedures (cognitive and other testing) and is fluent in the language used for the administration of the cognitive tests.
Exclusion Criteria:
- History and/or evidence of any other CNS disorder that could be interpreted as a cause of dementia: e.g. structural or developmental abnormality, epilepsy, infectious, degenerative or inflammatory/demyelinating CNS conditions such as, Parkinson's disease and frontotemporal dementia
- History of significant psychiatric illness such as schizophrenia or bipolar affective disorder that in the opinion of the Investigator would interfere with participation in the study; major depressive disorder (according to DSM-IV) in the past year; current active depression requiring initiation of treatment (or is believed to account for substantial degree of cognitive impairment)
- Evidence of the following disorders: current vitamin B12 deficiency, positive syphilis serology (unless neurosyphilis was ruled out) or active thyroid dysfunction (particularly suggestive of hypothyroidism), including abnormally high or low serum levels of thyroid stimulating hormone (TSH), where this is thought to be the cause of, or to contribute to the severity of the subject's dementia.
- History of alcohol or other substance abuse, according to the DSM-IV criteria, or recent or remote history of the same if that could be a contributing factor to dementia.
- History of intra cerebral haemorrhage due to any of the following causes: cerebral amyloid angiopathy, uncontrolled hypertension, cerebral arteriovenous malformation, coagulopathy, CNS vasculitis or any other condition that the investigator and/or medical monitor considers as a relevant risk factor for intracerebral haemorrhage
Recent (i.e.,<6 months from Screening Visit) cardiovascular event defined as:
- ST-elevation MI or non-ST-elevation MI, confirmed by cardiac enzyme elevation and ECG changes
- coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft )
- stroke of any etiology
- resuscitated sudden death
- prior carotid surgery or stenting procedure
- Poorly controlled hypertension despite lifestyle modifications and pharmacotherapy (either systolic blood pressure >160mmHg or diastolic blood pressure >110mmHg)
- QTcB interval >450 msec; or QTcB > 480 msec in subjects with bundle branch block based on ECG assessment at the Screening visit.
- HbA1c >12.0 at Screening, or uncontrolled diabetes in the opinion of the investigator.
- History of glaucoma or any other findings in the baseline eye exam that, in the opinion of the investigator, would exclude the subject from participation in the study.
- History of adult asthma (or reactive airway disease) manifested by bronchospasm in the past 6 months, or currently taking regular anti-asthmatic medication(s).
- Previous history of anaphylaxis, severe allergic reaction or history of hypersensitivity to any of the components of the formulation.
- Significant abnormalities on clinical chemistry, haematology or urinalysis at Screening, including clinically significant anaemia.
- History of chronic viral hepatitis (including presence of B surface antigen or hepatitis C antibody), or other chronic hepatic disorders.
Abnormal Screening blood tests exceeding any of the limits defined below:
- Alanine transaminase (ALT) or aspartate transaminase (AST) >1.5 x the upper limit of normal (ULN)
- Alkaline phosphatase (AP) and bilirubin >1.5X ULN (isolated bilirubin >1.5x ULN is acceptable if bilirubin is fractionated and direct bilirubin <35%).
- Calculated creatinine clearance < 30 ml/min (per Cockcroft & Gault) at Screening
- Other clinically significant abnormality on physical (including neurological), laboratory or ECG examination that could be detrimental to the subject in the opinion of the Investigator or could compromise the integrity of the study.
- Planned major surgery within the study period.
- Use of systemic steroids or other immunosuppressants within the last 30 days prior to screening.
- Current treatment with barbiturates, MAO inhibitors, butyrophenones, phenothiazines and other "conventional" antipsychotic within 30 days or 5 half-lives prior to Screening, whichever is longer.
- Treatment with antidepressants, (other than MAO inhibitors), thyroid hormones, atypical antipsychotics (e.g. risperidone), benzodiazepines and other sedatives / hypnotics unless prescribed at a stable dose for at least 2 months prior to Screening. Note: Benzodiazepines or other sedatives/hypnotics (including antihistamines) with half-life less than 6 hours can be taken on a prn (as needed) basis but must not be taken within 5 half lives prior to cognitive testing.
- Current treatment with known potent inhibitors of CYP3A4 (e.g. ketoconazole, rifampin, modafinil).
- Current treatment with known potent Pgp inhibitors (itraconazole, ketoconazole, cyclosporin, loperamide, diltiazem, verapamil, spironolactone, quinidine, bepridil, quinine, carvedilol)
- Cognitive tasks prescribed for cognitive rehabilitation and performed under medical supervision in the 6 months prior to screening and/or during study
- Investigational medications or devices including symptomatic AD treatment during the 60 days prior to the Screening visit, or within 5 half-lives of use of the investigational drug prior to the Screening Visit, whichever is longer.
Participation in another investigational drug (with the exception of anti-amyloid monoclonal antibodies [mAbs]) or device study where subject was treated chronically (i.e. > 1 single dose) with a study agent intended to impact AD progression during the 12 months prior to the Screening visit.
- Subjects who participated in an investigational drug study that involved chronic dosing with a monoclonal antibody at any time in the past are excluded from this study, unless it is known that they received placebo during the previous study.
- Subjects who participated in previous single-dose studies of anti-amyloid mAbs will be permitted provided the subject's dose of the mAb is at least 5 half-lives removed; the subjects did not experience any moderate adverse events classified as possibly drug-related or any serious adverse event during that study; the subject did not drop out of the previous study (i.e. completed all safety assessments)
- Subjects, who in the investigator's judgement, pose a significant suicide risk (e.g. history of suicidal behaviour in the last 6 months and/or any suicidal ideation of type 4 or 5 on the C-SSRS in the last 2 months).
- Subject or caregiver is an immediate family member or employee of the participating Investigator, any of the participating site staff or GSK staff.
Any contraindication to lumbar puncture or insertion of CSF catheter, including but not limited to
- Thrombocytopenia or other coagulation disorders (including subjects receiving coumarin-derived anti-coagulants or low-molecular-weight heparin).
- The presence of cutaneous or soft tissue infection overlying or adjacent to the site of lumbar puncture.
- Previous spinal surgery that could complicate access to the subarachnoid space.
- Suspicion of increased intracranial pressure due to a cerebral mass.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01428453
Please refer to this study by its ClinicalTrials.gov identifier: NCT01428453
|GSK Investigational Site
|Sofia, Bulgaria, 1113
|GSK Investigational Site
|Sofia, Bulgaria, 1431
|Canada, Ontario
|GSK Investigational Site
|Toronto, Ontario, Canada, M3B 2S7
|Canada, Quebec
|GSK Investigational Site
|Gatineau, Quebec, Canada, J9A 1K7
|GSK Investigational Site
|Sherbrooke, Quebec, Canada, J1H 1Z1
|GSK Investigational Site
|Ellwangen, Baden-Wuerttemberg, Germany, 73479
|GSK Investigational Site
|Tuebingen, Baden-Wuerttemberg, Germany, 72076
|GSK Investigational Site
|Ulm, Baden-Wuerttemberg, Germany, 89081
|GSK Investigational Site
|Alzenau, Bayern, Germany, 63755
|GSK Investigational Site
|Bad Homburg, Hessen, Germany, 61348
|GSK Investigational Site
|Achim, Niedersachsen, Germany, 28832
|GSK Investigational Site
|Hannover, Niedersachsen, Germany, 30559
|GSK Investigational Site
|Bochum, Nordrhein-Westfalen, Germany, 44787
|GSK Investigational Site
|Bochum, Nordrhein-Westfalen, Germany, 44791
|GSK Investigational Site
|Bochum, Nordrhein-Westfalen, Germany, 44892
|GSK Investigational Site
|Koeln, Nordrhein-Westfalen, Germany, 50935
|GSK Investigational Site
|Oldenburg, Schleswig-Holstein, Germany, 26122
|GSK Investigational Site
|Roma, Lazio, Italy, 00185
|GSK Investigational Site
|Genova, Liguria, Italy, 16132
|GSK Investigational Site
|Brescia, Lombardia, Italy, 25125
|GSK Investigational Site
|Milano, Lombardia, Italy, 20122
|GSK Investigational Site
|Verona, Veneto, Italy, 37134
|GSK Investigational Site
|Lørenskog, Norway, 1478
|GSK Investigational Site
|Baracaldo/Vizcaya, Spain, 48903
|GSK Investigational Site
|Barcelona, Spain, 08014
|GSK Investigational Site
|Castellón de La Plana, Spain, 12004
|GSK Investigational Site
|Getafe/Madrid, Spain, 28905
|GSK Investigational Site
|L'Hospitalet de Llobregat, Spain, 08907
|GSK Investigational Site
|Madrid, Spain, 28006
|GSK Investigational Site
|Stockholm, Sweden, se-141 86
Sponsors and Collaborators
|Study Director:
|GSK Clinical Trials
More Information
Keywords provided by GlaxoSmithKline:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01428453 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 1, 2011
|Last Updated:
|April 27, 2015
Keywords provided by GlaxoSmithKline:
Alzheimer's disease
Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders
ClinicalTrials.gov processed this record on September 21, 2017


text:
I also planted one Cherry Tomato, which I guess I didn't take a picture of. Yes, that's 17 tomato plants for those who are keeping score. I do have a big garden, and I love to give away tomatoes to everyone in the neighborhood.
I guess I forgot to take a picture of the bell peppers, so I'll show those another time. I'm also planning to plant spagetti squash if I can find a plant, and a few seeds for chard, arugula, and maybe even one type of lettuce, but I haven't managed to get that done yet!
In future weeks you can follow the progress of my garden by clicking the label 2007 Garden Updates at the end of this post.


text:
Hidden Villa has scheduled "The Interfaith Experience," its first youth-led day of conversation, information and sharing, 10 a.m. to 4 p.m. April 20 at the nonprofit organic farm, 26870 Moody Road, Los Altos Hills.
As part of a new social-justice-focused initiative adopted during the organization's recent Strategic Planning process, the inaugural "Duveneck Forum" will address community building, interfaith conflict and issues of social justice.
"My grandparents continually sought to use Hidden Villa to promote environmental education and advance issues of social justice," said Hidden Villa board member David Duveneck, grandson of the nature preserve's founders, Frank and Josephine Duveneck.
More than a dozen local high school youth representing myriad faiths have been involved in planning the topics, workshops and details of the event.
The conference, free to the public (though preregistration is required), is designed for teens, their families and teen leaders.
According to organizers, the goal is two-fold: to teach young people how to bring diverse perspectives together to facilitate positive community building, and for participants to discuss how to use their experiences and beliefs to strengthen one another and make the world a more tolerant and interesting place.
Keynote speakers Sumbul Ali-Karamali and Jim Burklo will kick off the conference. Ali-Karamali is author of "The Muslim Next Door: The Qur'an, the Media, and That Veil Thing" (White Cloud Press, 2008). Burklo is associate dean of religious life at USC and author of "Hitchhiking to Alaska: The Way of Soulful Service" (St. Johann Press, 2013).
Following a morning session that includes a youth-led panel and small-group interfaith discussions, the afternoon will include interactive workshops exploring how art, nature, dance and issues like discrimination relate to community and faith. The event will conclude with a presentation on how to move from discussion to implementation and a musical celebration.
To register or for more information, call 949-9704 or visit www.hiddenvilla.org.


text:
Marketing Information
HP 24x7 Software Technical Support provides comprehensive round-the-clock services and cost-saving updates to help you enhance the performance and availability of software from HP and other leading vendors.
General Information
|Product Type
|Manufacturer Part Number
|Manufacturer Website Address
|Service Name
|Care Pack
|Brand Name
Service Information
|Product Supported
|VMWare Site Recover Manager
|Service Availability
|24 x 7
|Service Details
|24x7x365 access to technical resources:
Connect with HP Response Center engineers via telephone, electronic communication, or FAX for assistance in resolving software implementation or operations problems. Service is available around the clock every day, including all holidays.Problem analysis and resolution:
HP Services provides corrective support to resolve identifiable and reproducible software product problems, and to help you identify problems that are difficult to reproduce. You can also receive assistance in trouble-shooting problems and setting configuration parameters.Software features and operational support:
HP provides information on the latest product features and known problems and solutions, plus operational advice and assistance.Installation advisory:
Advisory support is available for help with installation and updating of standalone applications or products installed in a network environment.Software updates and licensing:
Complete HP and selected third-party software product and documentation updates are available to your system manager. You receive a license to use and copy software product updates for all systems covered by the original software license.Electronic software information:
Access HP's electronic support facility for software patches, a symptom-solution database, product descriptions, specifications, technical literature, and more.
|Service Duration
|3 Year
|Service Main Type
|Service Sub Type
This product is shipped only within Canada and Warranty valid for Canada only.
Computer Valley makes every effort to provide accurate specifications, descriptions, images and price on all products that are found on www.computervalley.ca
However for complete and updated descriptions, compatibilities, specifications and actual photo we recommend our clients to consult with manufacturer's websites or simply call us for proper clarifications. Computer Valley is not responsible and will not accept returns for items purchased that are not compatible with your system. Please ensure that you have verified compatibility and actual photo with your system by visiting the manufacturer's web site prior to purchase or give us a call to make sure what you are purchasing.
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|Read Reviews Write Review


text:
Hi All,
This is the self section of my work Alpha.
You. I.
A living thing.
The inward continuation of a form based upon the creation of a new point of inner continuity. The form inwardly continues in regard to the new point of inner continuity.
The self is the new point of inner continuity and all points of inward continuity.
The inward inner continuity of self can be recognised by the self as feeling. Feeling increases.
The continuity of self is based in regard to new positioning by the ever inward centre.
The determinant of state of self is ones positioning by the ever inward centre. Three aspects of that positioning are mental focus balance and breath. All three are intrinsicly interlinked and increase concurrently.
Mental Focus
Mental focus is the force of the mind.
By act of mind mental force goes forward to a point ahead of the self.
Focus forward to a point ahead of yourself.
(Ive posted the balance and breath parts of this section under new threads so as to make each thread more specific. The full work Alpha can be found here http://www.rickybennison.blogspot.com)
All the Best Ricky


text:
DsmDisc wrote:masterbeato wrote:JR wrote:You have to design your own discs if you want to be able to continue limiting distance with disc selection. Unless you wanna finesse lids. So realistically you're at a problem where everyone would love to be having to learn to control your power.
Thanks JR, I am trying to make some money to make trips out to different states to give some people some hands on lessons.
people have never made any requests for me to travel, so i had no motivation and i highly suggest people to make those suggestions and i will do my best to make it out there because i need to get the hell outta this state once in a while! lol
if i get supplied a couch to sleep on and a plane ticket or food i will supple gas if i have to drive, or food if i have to fly. or i will just bring my own food and i can stay for a week or so and i would be more than happy to head out to wherever and help them out with their game if that is what people would like to do.
If you ever want to come to Des Moines some time, me and my buds would be glad to throw a few rounds with ya. I've got a comfortable couch I could spare for a few days. I've finally started to settle down my form a bit, and feel like I'm a few good pointers and some practice away from crushing some drives. If you wanted to drive down I could fund the food expenses as well.
We've got a few beautiful courses down here, you would not get bored playing them.
i have been down to des moines last year and i loved it, i wanna go back this year and play disc at those awesome courses and stay for a few days that would be pretty cool, i am only 4 1/2 hours away so making a trip there soon to maybe play a tournament as well some weekend.


text:
HAYWARD — The body of a homeless woman was found in a makeshift shelter behind a grocery store Monday night, police said.
When police arrived about 6:30 p.m., they found Hope Williams, 43, inside the shelter near a wooded area behind the Food Maxx at 30073 Industrial Parkway, said Hayward Police Sgt. Mark Ormsby.
She was pronounced dead at the scene, Ormsby said. Foul play is not suspected, he said.
The Alameda County Coroner's Office has not yet done an autopsy to determine the cause of death, a spokeman said Tuesday.
Anyone with information about this incident can call police at 510-293-7000 or at the anonymous tip line at 510-293-7197.
Contact Natalie Neysa Alund at 510-293-2469. Follow her at Twitter.com/nataliealund. Reach Kristin J. Bender at kbender@bayareanews


text: OverviewBack to top Macadamia Natural Oil - Flawless Foam 6-in-1 Cleansing Conditioner - 8 oz. CLEARANCED PRICED Item# :128944UPC# :815857010078 Brand:Macadamia Natural Oil Size/Form:8 oz. Ship Weight:0.65 Macadamia Natural Oil Flawless Foam - 8 oz. (250 ml) Cleanse, condition, refine and perfect with Macadamia Natural Oil's Flawless Foam: The Ultimate 6-in-1 Cleansing Conditioner. Macadamia Natural Oil's Flawless Foam is an innovative system that combines cleansing, conditioning and ideal hair refinement in one product. With Macadamia Natural Oil's Flawless Foam, immediate and perfect balance is restored to any hair type, giving gentle and thorough surfactant-free hair cleansing. Macadamia Oil and Argan Oil work in conjunction with the hair's natural oils, replenishing hair life and health and imparting manageability, shine and softness. 6-in-1 cleansing conditioner Refines Hair Texture Optimizes Styling Process Drastically Cuts Down Blow Drying Time Perfect For All Hair Types Surfactant-free and Paraben-free No Stripping Suds Experience Perfection Reinvent the art of shampooing with Flawless, an innovative 6-in-1 cleansing conditioner that cleanses, conditions, reduces blow-drying time, detangles, enhances volume and eliminates frizz in one product. Flawless recreates the perfect salon blow-dry at home. How It Works Flawless' innovative formula dispenses as a lightweight, no-suds mousse that gently and thoroughly cleanses without stripping hair or weighing it down. At the same time, it conditions and infuses hair with nourishing macadamia oil, chamomile, vitamin E, proteins and other nutrients. Hair is left revitalized with healthy shine, bounce and manageability. Frequently Asked Questions: Are the Healing Oil Treatment and Oil Spray Alcohol-Free? Yes, Macadamia Natural Oil's amazing Healing Oil Treatment is indeed alcohol-free, as well as their Healing Oil Spray. What is Macadamia Natural Oil and how is it different from regular macadamia nut oil? Macadamia nut oil is a highly beneficial oil expressed from the macadamia nut meat of the macadamia tree. It has been found to be highly beneficial for hair, scalp, skin and general health. Macadamia Natural Oil is a luxury brand of haircare products for the professional beauty industry. The brand blends two of the world's most precious oils, Macadamia Nut Oil and Argan Seed Oil, to create lightweight, highly absorbent exceptionally restorative products. How does the Healing Oil Treatment reduce drying time by up to 50%? As you know, oil and water separate - so when the oil is absorbed into the hair it basically pushes water trapped under the cuticle out and allows it to dry faster. The heat from the blow dryer reduces the viscosity and enhances penetration even further. Drying time can be reduced upwards of 40-50% due to this effect, which not only saves you time but also minimizes exposure to heat-related hair damage. Does Macadamia Natural Oil test on animals? No, Macadamia Natural Oil does not test any of its products on animals. They are a cruelty-free line of products across the board. Why is Macadamia Natural Oil different from all the other 'hair oils'? Macadamia Natural Oil is extremely light weight and highly absorbent. The oil's unique composition is remarkably similar to our body's own natural oil. It also has an extremely high concentration of Omega 7 acid, which is our body's own natural moisturizer. These two factors enable Macadamia Natural Oil to promote healthy hair growth, not just healthy hair maintenance. Are the Macadamia Natural Oil products pH Balanced? The Healing Oil Treatment and Deep Repair Masque have a pH of 5 making them ideally balanced for your hair and skin's natural pH. The Rejuvenating Shampoo and Leave-In Cream have an appropriate 6.5 pH. Is the Deep Repair Masque Paraben-Free? Yes it is. Is Macadamia Natural Oil 'all natural'? The Macadamia Natural Oil hair products contain many natural ingredients, even above and beyond their featured Macadamia and Argan oils. However, for maximum performance Macadamia Natural Oil has determined that their products need also contain ingredients that do not fall under the "natural" definition in order to achieve enhanced benefits as well as to sustain the oil, maintain a competitive shelf life and allow the Macadamia and Argan oils to remain blended and not separate. Macadamia is a nut, so what about people with nut allergies and allergic reactions? Contrary to common belief, the Macadamia "nut" is actually a seed, not a nut at all. It belongs to the Proteaceae family, which are classified separately from most other tree nuts and from peanuts. Allergens are less common than in other tree nuts or peanuts. The oil from the Macadamia "nut" may cause a reaction the select few people with Macadamia-specific sensitizations, but even then it depends on the method of processing. The 17.4 dDa protein which is the primary allergen is only present in raw and roasted extracts. Macadamia Natural Oil has done extensive allergy testing and the conclusion, based on this and the fact that there have been zero reports of any incidents, is that the Macadamia Natural Oil products do not cause allergic reactions even in those suffering from nut allergies. Macadamia Natural Oil does recommend, however, for those people who have nut allergies, to err on the side of caution and rub a small amount of the Healing Oil Treatment on the skin to test. Is Macadamia Natural Oil better than all of the other "hair oils" on the market? Macadamia Natural Oil is an outstanding product in every way. Since the consumer and stylist purchase products based on performance and personal preference, this question can only be answered by them. For the record, Macadamia Natural Oil believes that it is. Can Macadamia Healing Oil Treatment be used on the body as skin care? While Macadamia Oil has been used in cosmetics for centuries, Macadamia Natural Oil doesn't encourage using its Healing Oil Treatment oil for skin care, as it is specifically formulated for optimal performance as a hair product. Is the Rejuvenating Shampoo Sulfate Free? Yes, Macadamia Natural Oil's newly formulated Rejuvenating Shampoo is sulfate-free, paraben-free and color safe. Do Macadamia Natural Oil hair products contain any silicones? Silicones have been given quite the bad rap recently by those who overgeneralize, claiming negative effects such as build up, drying and hair "suffocation". As one might expect, its not quite as cut and dry as rumor would imply. You cannot realistically argue that ALL silicones are bad for your hair, or even your skin for that matter; there are a large variety of types as well as levels of quality that make it very difficult to prejudge a product just because a "cone" is in the ingredient list. In general, silicones serve many positive functions in haircare: reducing moisture loss, humidity-proofing, cuticle sealing and protection, detangling, and shine enhancement. Some silicones are heavy and thick, some are quite water soluble and quickly evaporate; moreover, they can also be used in combination with each other and other ingredients to achieve a multitude of desirable effects. One of the things that makes Macadamia Natural Oil hair products stand apart is that they use a customized blend of uncommonly high quality silicones. These premium ingredients, when combined with Macadamia Natural Oil's other signature components, play an important role in producing the incredible results that their products are known for: Unprecedented softness, shine, manageability and protection with no greasiness or buildup. Words really don't do justice though; you'll need to experience the results first-hand to truly appreciate what these products do for the health and benefit of your hair, silicones and all. Is the Moisturizing Rinse Conditioner Paraben-Free? Yes, it is indeed paraben-free, sulfate-free and color safe. Macadamia Natural Oil's Story Macadamia Natural Oil products meld the lightweight and nutrient-rich properties of Macadamia nut and Argan seed oils to revitalize even the most problem hair, nourishing from root to tip for effortless health and beauty. In A Nutshell Macadamia Natural Oil is a premium, professional hair care line focused on healing and beautifying problem hair via a modern application of Macadamia and Argan oils. Macadamia Natural Oil's focus is on the curative powers and results of our time-tested, nature-based ingredients. Macadamia Natural Oil's Philosophy Their ultimate passion at Macadamia Natural Oil is to set people free from the burden of problem hair; whether it's damaged, dry, frizzy, lifeless, or just hard to manage. Macadamia Natural Oil empathizes with the needless daily suffering that goes on in many women's lives when it comes to dealing with these issues and have thus made it their mission to deliver the joy of healthier, more manageable hair and the satisfaction of an infinitely easier and faster daily routine. Hearing the inspiring accounts of how their products have notably improved a person's quality of life really touches Macadamia Natural Oil and lets them know that what they offer is more than just another line of hair products. When it comes right down to it, this is what Macadamia Natural Oil strives for: To have a positive impact on people's lives. "Problem Hair" Defined The Macadamia Natural Oil line has been created specifically to help those with "problem hair". If you feel that your hair has one or more of the following "problems", Macadamia Natural Oil products will be a can't-live-without addition to your daily beauty regimen. damaged (chemicals, wind, sun) frizzy dry colored, straightened, permed hard to manage tangled dull, lifeless brittle, not soft, lacking "touchability" out of control, wild thick, bushy The History Macadamia Natural Oil melds the unique properties of macadamia nut oil and the rare luxury of argan seed oil to create the ultimate in everyday indulgence; a product that heals, nourishes, revitalizes and rejuvenates even the most problem hair. Each tree's harvest is rich in essential fatty acids so vital to hair health; each seed's oil is a cherished secret of the most beautiful women in the world. For thousands of years, the macadamia nut has been renowned for its high nutritional value and health-promoting benefits. Today, macadamia oil is now also widely revered for its incredible benefits to hair, skin and overall health by promoting shiny hair and radiant skin. Why It Works Remarkably lightweight, macadamia oil's unique composition gives it an uncanny similarity and compatibility to sebum, the natural oils our own scalp produces. It's this unique similarity that makes it so effective, allowing the oil to infuse into hair and scalp with extraordinarily fast absorption and penetration; restoring health, softness and shine; and shielding the hair from chemicals, heat and damage through its natural UV protection. Argan seed oil, known as "liquid gold" to Moroccans, has been used by countless generations for its beneficial use in skin, hair, nail and therapeutic treatments. This rare and difficult to obtain oil restores shine and softness to dry, brittle hair while nourishing hair damaged by chemical services. Why It Works Argan seed oil is exceptionally rich in natural Vitamin E, Omega 9, Linoleic, Oleic, and unsaturated fatty acids. It is this decadent composition that has made the deep, thick, glossy hair of those exotic Moroccan women the envy of all others for centuries. One of the most precious and luxuriant emollients on Earth, it rejuvenates hair from root to tip, increasing strength, elasticity and overall health. Benefits Of The Oils Together, macadamia oil and argan oil replenish the hair's natural emollients with the high content of essential fatty acids found naturally in both of these exceptional oils. The combined benefits help to nourish and protect the hair from harmful UV rays while repairing hair follicles for improved elasticity and shine.


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Posted 6 years ago
(1 item)
This piece looks to be hand crocheted. It has small flat copper diamond shaped pieces that are folded over on the ends with the thread passing through the openings. It is about 6 feet long and two feet wide. It is real copper. It is quite old, maybe turn of the century? I am trying to figure out its age, or anything else about it. I've never seen anything quite like it. Thank you for your help!


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RANCHO CUCAMONGA — Two free workshops on reducing water use and growing healthy organic items will be held April 20 co-sponsored by University of California Cooperative Extension Master Gardeners and the Frontier Project.
The workshops:
9 a.m. to noon — Water Efficient Sustainable Landscapes: Save water and beautify the yard.
1 to 4 p.m. — Edible Landscapes: Add organically grown fruits and vegetables to the landscape.
The workshops will be at the Frontier Project, 10435 Ashford St., Rancho Cucamonga.
Information or to RSVP: Debby Figoni, 818-815-8735 or email@example.com


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CrawfordHollow wrote:Does anyone know whats up with the replay site? I was able to get into once with my password, then it wouldn't work for a month, then I got into it last night, now it wont work again, I use the same password every time. Anyone else have problems?
copy and paste doesnt work when you login in.
try typing your details.


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If you're headed to this year's Treasure Island Music Festival make sure to swing by SFZF's Reading Tent, where we'll have our zine library available for attendees to browse and read through.
Curious on more info about the Treasure Island Music Festival? Find them on Facebook and follow them on Twitter for updates -- this year features a great lineup!


text: The BYU Cougars returned to practice Monday night "more determined and resolved," coach Bronco Mendenhall said, after Saturday night's embarrassing 20-14 loss to San Jose State. "The time to be down was the plane ride home and [Sunday]. Now it is right back to work," Mendenhall said. The Cougars started working on a game plan for New Mexico State (Saturday, 1:30 p.m., ESPN3) on Monday. They will change their routine only slightly this week, practicing early on Thanksgiving Day to be done by noon. Of course, the big questions Monday focused on the health of quarterback Riley Nelson and star receiver Cody Hoffman. Regarding Nelson, Mendenhall said: "He's hurt. And hopefully he will be back by the game. But he got pounded in that game. Took a lot of shots. So he didn't practice today. Hopefully he will be back by Saturday." Trainer Jeff Hurst said Nelson "had an injury to the spot where the rib attaches to the cartilage in the front of his right side. No fracture that we can look at right now. It is progressing daily. Felt better today than yesterday. Better Sunday than it did Saturday after the game. So it is kind of a day to day thing right now." I think he has a huge heart and a ton of desire and willingness. It wouldn't surprise me at all if he were ready to go." I asked Mendenhall what chance he would give Nelson of playing on Saturday. "I don't know enough about it yet," he said. "I probably will know more and more as the week goes, but for him to be out today is pretty significant, because the guy doesn't miss many [practices]." Hurst said Nelson is officially listed as "day-to-day." There's better news as far as Hoffman is concerned. The junior wideout practiced on Monday after suffering a shoulder injury against SJSU. "I think he will be fine, from what I have been told," Mendenhall said. Hurst said Hoffman "did great," in practice. "Looked real good. Real tough kid. He was out here, ran some team reps and went pat and go, and some of the indy stuff. Definitely we will keep him off the ground ... through practice. I would say Saturday he will be good to go," Hurst said. There are some who saw the pain Nelson was in on TV and believe that Mendenhall should not have played him in the fourth quarter."The team respects [Nelson and Hoffman], and they gave us a great chance to win the game. Cody came in after the long drive and recovered the onside kick. Riley just scrambled all over the place and threw it to David Foote and we got close. Just didn't protect well enough to win it," Mendenhall said. The coach was asked how close he has been this season to handing the quarterbacking reins to backup James Lark. "Not really close. Not because lack of trust. I have tried to explain why Taysom Hill was the backup, in terms of continuity of system with Riley. During the last game, a couple of times, it was maybe a breath or two away from putting James [Lark] in. And he will play and he will start this week if Riley can't play for any reason." More comments from Mendenhall after practice:On a season like this and whether the QB is getting too much blame:"No question. The guy, he does everything he possibly can to help our team. But offensive execution is protection, it is route running, it is protection by the running backs, it is check-down routes, etc. So yeah, he's most visible, and he's handling that really well. But [we've] one or two plays, it seems like in a bunch of games. But also in every game right to the end, and Riley has given us a chance to do that." On whether it is tough to make big changes because they are close to winning some of these games: "I think to a point, but intuitively, and as the leader, as you keep watching, and hopefully as objectively as possible, you know whether they are minor tweaks or whether they have to be significant, and that's hard to notice that really during the year as much. Bye week it is easier to kinda step back. Other times maybe after a couple in a row you might be able to step back. But it is hard to say. Each leader kinda has to pick and choose during the season and do the best he can." On the new playoff system and where BYU fits: "It is about the same access we had before, the way I see it. So we will still have to be undefeated I think, to be considered." On whether there was any overconfidence vs. San Jose State:"Not necessarily. I don't really think it had anything to do with the beginning. They made a couple nice downfield throws, and they made them all early, and then it went to business as usual. They had a nice plan to try to get a lead, but after that our guys adjusted well. So that's the way I saw it."


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Memories of catching movies, sipping on Cokes at Kresge's, hanging out with friends after school or simply working to pay the bills: These and many more flooded the minds of those overcome with nostalgia when remembering the Summit Place Mall. The Oakland Press recently shared a photo of "The Mall" and its signature entrance with Facebook users, which drew hundreds of comments from readers waxing nostalgic about their time in this piece of local history.
Summit Place, formerly known as the Pontiac Mall, was a major shopping destination for the area from its construction in the 1960s until its mid-90s decline. The mall finally closed its concourse in 2009 after a majority of its stores relocated or went out of business.
The mall is notorious for its apparent contribution to the decline of Downtown Pontiac's commercial appeal, and it subsequently suffered in the wake of the opening of Great Lakes Crossing. It was also the burial site of Little Jenny, an elephant starring in the 1954 film "Elephant Walk" that died during a circus held at the mall site, according to an Associated Press report from 1972.
Oakland Press readers recently responded to a 1983 photo of the mall's main entrance with memories of countless hours spent hanging out in one of Oakland County's premier shopping locations.
James Bezner said the mall, especially under its original name, holds a special place in the memories of area teenagers.
"It always will be known in the hearts of us who were teenagers in the 70s as the Pontiac Mall," he said. "In fact, that is probably my 1970 Pontiac LeMans in the parking lot!"
Mike Carlock said it was the place to be as a teenager.
"For us, it was the only place to shop until Lakeside opened in Utica," Ron Kerns said.
"I used hang out there in the late 80s and early 90s," said Cynthia Sargent-Elliston. "I miss it."
Kari Corbin-Stout said, "I used to skip school to go hang out there! Got into alot of trouble there."
"Every Saturday in 8th-9th grade we would meet at the Pontiac Mall, walk around and then sit in a booth at the windows of Kresge's watching all the people, while eating French fries and sipping on a coke," said Sue Turner Mason. "What a hoot!"
Lisa Granado also remembers frequenting Kresge's quite often.
"I was just talking about Kresge's the other day," she said. "My mom use to take us there for lunch after shopping sometimes when she couldn't afford taking us on the top floor to Hudson's little restaurant."
"I remember the first day it opened," said Bonnie Beacom Jones. "I used to ice skate on a piece of land before it was built. Time slips away fast."
Nancy Perkins remembers the early days of the mall as well.
"We watched it being built," she said. "We had never seen anything like it! When you drove by, you could see stores inside the main doors. My mom worked in the main office upstairs for a while, we were just talking about this. My family used to do a lot of shopping there."
Many other readers held jobs in the mall throughout the years, such as Christina Sebert, who worked three different jobs there. For Kathy Kelley May, it was the first job she ever held.
"My first job, about 42 years ago, was at the Coney Island in the Pontiac Mall," May said. "I also remember a travel agency that was there. And Ted's Cafeteria. My grandma, Rose, worked there and made the best chocolate pies!"
The fact that the site sits practically abandoned now isn't lost on many.
Donna Rodgers said "I went there a couple of years ago taking a trip down memory lane and the only store left was Sears. It was just deserted. It was really sad."
"It's worse than a ghost town," said Justin Bratcher. "It's Chernobyl. No business wants to go near it. Only Sears remains. They must have a really sweet deal to stay. Don't get me wrong; I'm glad they're still there, but how much longer are they?"
Jackie Benedict remembers the mall's growth and decline during her time in Waterford.
"I grew up in Waterford, so I watched it grow, then watched it turn into a ghost town," she said. "So sad, it used to be my place to shop."
Though the mall sits vacant, it lives on in the memories of those who spent countless hours roaming its corridors.
Contact Andrew Kidd at 248-745-4630 or email@example.com. Follow him on Twitter @andrewjkidd.


text: Maybe, but this is his most efficient season to date and the first season he has been a number 1 option. Much like with Trent Richardson for the Colts, there are a lot of red flags there that have me worried.This quote is hidden because you are ignoring this member. Show Quote


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I have about 300 feet of distance. I throw forehand and backhand equally. I like minimalism, despite the fact that I'm a recovering disc whore, and like that my discs fit in a Spider Monkey with room to spare.
Star Xcaliber - overstable
ESP Surge - primary forehand driver
DX Gazelle - primary backhand driver
X Stratus - understable mid/driver
DX Roc
X Comet - since I don't have a beat Roc
Pro Rhyno - putter drives, approaches, long putts
D Magnet - inside the circle
I'm not excited about having two putter molds. I love the Pro Rhynos for most shots, but recently I've been working on my putting form and found that for short putts the stiffness of the D Magnet works a little better, so there it is. The Stratus comes and goes since it isn't that different from the Comet, and I tend to throw flicks instead of BH anyhzers. Right now it's in the bag, but I rarely use it. Open to thoughts and suggestions...


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When I started in chapter1, my reading speed was 165. By the time the course ended I was up to 642. While this may not seem very high for other students, it was quite an accomplishment for me, being that English is my second language. I will continue practicing and will get faster. I really liked this course, and will recommend it to my friends.
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Tomlin roughed up as Indians fall to Reds
Righty's struggles continue; fluky play stalls potential rally
CLEVELAND -- Every few games, it seems that more questions arrive than answers for the Indians' starting rotation. Cleveland has lacked prolonged stability from its staff throughout this season, keeping the club from moving beyond the fringe of the postseason discussion.
The latest issue arrived on Tuesday night, when Josh Tomlin returned from Triple-A Columbus and labored in a 9-2 defeat to the in-state rival Reds at Progressive Field. Cleveland was stymied by right-hander Johnny Cueto and a fluke play went against the Tribe in the seventh, but the abbreviated outing from Tomlin laid the groundwork for the loss.
"That's on me," Tomlin said. "That can't happen."
The defeat ended a modest four-game winning streak for the Indians.
Cleveland's task now is trying to find some consistency from the fifth spot of its rotation. Tomlin's next scheduled start is Sunday on the road against the Yankees, but the Indians will likely use the next handful of days to evaluate their alternatives.
Due to the timing of four team off-days this month -- including two next week on Monday and Thursday -- the Indians have the ability to shuffle their starting staff some. Cleveland could provide some arms with extra days of rest or potentially skip a starter in certain spots. On Sunday, the Indians could also consider giving reliever Carlos Carrasco -- who went four innings in relief of Tomlin -- another look.
Indians manager Terry Francona would not commit to any firm plan immediately following Tuesday's loss.
"We have some days off coming up," Francona said. "So we have the ability to look at it and do what's in our best interest. One of the things we'll certainly check is, we'd like to run Corey Kluber out there as much as we can, but I think you want to communicate with him after he pitches to see if extra rest helps him or it doesn't.
"That will be our first option and decision, and then we have some different scenarios in mind. We have some things that we need to think about in the next 10 days."
Tomlin -- summoned from the Minors to replace the recently-demoted Zach McAllister -- was the recipient of some bad luck in the first inning, when a fielding error by third baseman Lonnie Chisenhall led to an unlikely run for the Reds. Chisenhall botched a routine catch on a relay throw during a double by Ryan Ludwick, allowing Todd Frazier to score from third.
Cincinnati then piled on three runs against Tomlin in the second inning. With two runners aboard and no outs, Ramon Santiago pulled the first pitch he saw from the righty deep to right field for a three-run home run to push Cleveland behind, 4-1. It marked Santiago's first home run of the season and his first since Aug. 16 of last year.
"The three-run homer to Santiago," said Tomlin, "I just tried to locate a two-seamer down and away and it stayed down the middle of the plate. That kind of changed the momentum of the game."
The 17 home runs allowed by Tomlin this season are the most in the Majors among pitchers with no more than 90 innings logged.
In the fourth inning, Tomlin yielded a leadoff triple to Zack Cozart, who scored on an infield chopper off the bat of Jay Bruce. The Reds tacked a sixth run on Tomlin's line after his exit in the fifth, when left fielder Chris Heisey scored from third base on a throw to second by Cleveland catcher Yan Gomes to catch Brayan Pena stealing. Tomlin was charged with six runs (five earned) in his 4 1/3 innings of work.
The Indians (57-56) struck for one run against Cueto in the first inning -- courtesy of a one-out RBI single from All-Star Michael Brantley. The Reds right-hander, who entered the evening with a 2.05 ERA, then held the Tribe to a 1-for-17 showing at the plate before finally flinching again in the seventh.
Chisenhall opened the frame with a walk and David Murphy followed with a single to right, putting runners on the corners for the hot-hitting Gomes. The catcher slashed a line drive into the right-field corner, plating Chisenhall and sending Murphy hustling around the basepaths.
As Bruce retrieved the ball in right field, Reds reliever Jumbo Diaz threw an extremely wild pitch in the visitors' bullpen behind the right-field wall. The baseball unleashed by Diaz landed near cutoff man Kris Negron, who was reeling in Bruce's relay throw. With two balls in play, Murphy got confused, took too many steps toward home plate and was cut down at third for an unlikely out.
"Of course, it's frustrating," Murphy said "My intentions were to stay at third. I don't really know how to break it down with words. It's frustrating, because of the situation we're in, because we have momentum, we're trying to make a comeback. That happens, and an out like that in a rally like that kind of kills it."
Francona emerged from the dugout to discuss the bizarre play, but the umpires did not conduct a review and the game continued. Cueto recovered by retiring the next two batters he faced to escape further damage.
"[Third-base umpire] Gerry Davis, his explanation was right on," Francona said. "It wasn't fun to hear. I thought I saw what I saw, but they can't kill the play until the conclusion. I understand the rule. They said, 'We understand your frustration. There's nothing we can do,' which I understand."
The Reds complicated things even more for Cleveland with three runs -- one on a home run by Bruce -- off Carrasco in the ninth.
The loss was pinned on Tomlin, who is 1-5 with a 6.04 ERA over his past nine starts, which includes his brilliant one-hit shutout on the road against Seattle on June 28. More recently, Tomlin has gone 0-3 with a 7.09 ERA in five outings for Cleveland since the beginning of July.
"I'm very aware of how much I'm struggling the past however many starts," Tomlin said. "Now, it's time to figure something out and get a lot better."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. This story was not subject to the approval of Major League Baseball or its clubs.


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"Hey guys! Mind if I sue you some? I know you're going out of business and all. I thought the legal process would go smoother if I hit you while you were down. Eh? Good idea, am I right? Kodak? You aren't mad are you? Eh? Come on! We are still friends!" #OneRottonApple
Honestly if I didn't enjoy my iPhone this much I would boycott apple products. Seriously though, if apple were to be successful in getting rid of all the competition, only the wealthiest will be able to afford anything apple. Maybe the world population that owns an idevice should band together and sue apple for suing to much. The company needs to be renamed Suepple
This is a preemptive protective measure for patents Apple owns or partially owns from being made public or sold off after the bankruptcy, rather than anything against Eastman Kodak directly.
But does that matter? No, because you hate apple and have to throw in your useless 2 cents worth of stupidity without doing a little research!
Maybe Michael Essany should do some research too before writing a blatantly slanted story just to rile people up.
I wonder if there is a connection between photography, shared patents, and Kodak in relation to Apple. Jbardi clearly has had the most valid thing to say on this thread. Furthermore, amoamare, do you just like to hear yourself talk? Wtf is the point of your comment. Go to sleep.
The way I see it is that young generation programmers and technology students aren't going to be able to invent or make anything because they might be infringing Apple's property. There should not be a law allowing companies to sued each other for infringement, of course that doesn't mean that a company can just make an exact copy from some other product.
example: if im inventing a new type of technology and somebody else is doing the same at some other place and that person patent that technology that means i can't use it, fucx up...


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This game was classified by the community with the following category scores - Violence=0/3, Sex=0/3, Mature Content=0/3. Run, jump and roll to the beat in the easy-to-learn tricky-to-master most addicting sheep game.
Buy Xbox content on Xbox.com. Your Xbox 360 console will automatically download the content next time you turn it on and connect to Xbox Live.Learn More


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5th Class Result 2013 PEC Sahiwal
Punjab Examination Commission arranged Exams of Class 5th in the month of February 2013 and now Punjab Examination Commission (PEC) is going to declare the results for class 5 in the Sahiwal district on 31st of March 2013. As soon as the result for 5th class will be announced by PEC, we will update 5th class result on this page.
PEC has declared the date for announcing the result of class 5 and that will be on 31st of March 2013. All the students that appeared in the 5th class exams are waiting for their 5th class results very curiously, stay on this page for daily regular updates about 5th results 2013.
Class 5 Exam is compulsory for all the students in Punjab Province so if anyone says that 5th class exams are optional than it's totally wrong. 5th class students must have to appear for the exams under Punjab Examination Commission (PEC) rules and regulations.
5th class result 2013 Sahiwal


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ESPN has again brought 100 voters together to try to project the records of teams and certain awards. The Eastern Conference projected standings were released today, and since PD has had quite a bit of discussion on how the Pacers stack up against the rest of the East after the offseason moves, I thought this would have some insight into how national people think:
Some highlights:
First, a point about the actual records. When building a consensus like this, the records are always going to be flattened out somewhat. So there will probably be more than 1 team in the East win more than 50 games, and there will probably be more than 2 teams in the East win less than 30. But when calculating averages between a large sample of voters with divergent opinions, that's what they came out to.
The Heat have a 10 game advantage over anybody else. The Heat would have already been on a different level than anybody else, and add in the respect given to defending champions and this is not shocking whatsoever.
The Celtics and the Pacers are both projected to win 50 with the Celtics slightly ahead. So the thought that some Pacers fans are homers for just suggesting that the Pacers are on the same level as the Celtics appears to be incorrect. It may or may not actually be true, and there certainly is room for divergent opinions, but it's not just Pacers fans saying it. It seems to be the prevailing opinion going into the season that those two teams are close.
What did surprise me though was right after that. There's a four game gap down to the Bulls, with the Nets, 76ers, and Knicks close behind them. A four game gap in an exercise like this is huge. It clearly shows that while some individual writers might put one of these teams in the top three spots, as a whole they consider them a step below than the Celtics/Pacers.


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The University of North Carolina's 17 campuses extend from the state's mountains to the coast. More than 220,000 students are enrolled at 16 universities and the NC School of Science and Mathematics, the country's first public residential high school for gifted students. Each year, we graduate more than 30,000 students from over 200 academic degree programs. Our graduates emerge as leaders, creators and researchers, prepared to connect with and give back to the communities that have supported UNC for more than two centuries.
Click on a campus below to visit its website.
Explore our County Connections Map to learn how UNC teaching, research and service touches every part of our state.
10. UNC Charlotte
11. UNC Greensboro
12. UNC Pembroke
13. UNC Wilmington


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Compare AC Garages and Specialists in Newbury with Who Can Fix My Car.
Enter your registration to check prices and reviews, and get your AC booked in today!
Compare AC Garages and Specialists in Newbury with Who Can Fix My Car.
Alex from Howat Automotive provided a very honest and reliable service. Accommodating of all of my cars (regular service, engine coolant leak troubleshooting) needs as well as collecting and dropping of the car. Honest and flexible pricing. I would definitely recommend to others as I plan to use again myself.
Alex was very polite in dealings prior to the service. Picked up the car on time and dropped back at the time agreed. No initial concerns with work and I am confident there won't be in the future. Would recommend Alex to anyone looking for a service
Alex from Howat Automotive performed a 60K mile service on my Skoda Fabia. He collected and returned the car from my home 15 miles from the garage, same day. His quote (all in) was £30 cheaper than my local garage. His manner was friendly and professional, and he had quite unexpectedly cleaned the car (which was filthy) at no extra charge. I am very impressed, and would recommend him.
Excellent service - polite and friendly, competitive prices, quick response and good quality service.
Top service , highly recommend. Thanks
Did a great job. They did it when they agreed in the time frame specified. Very happy
Very friendly service, work comes with 12 month guarantee. Though it took two weeks to do as came into other problems the car runs like a dream.
Found aircon leak and properly repaired and pressure tested excellent service and very well priced would definitely recommend thankyou to all the team.
They were excellent
Good quick service
Did a really good job, would happily recommend and use again.
I used Miller's for a full service. The garage has a clean and welcoming reception area. I received great customer service which surpassed expectations. Simple, yet detailed description of problems after the service was complete. I was treated to a surprisingly pokey courtesy vehicle whilst mine was being serviced. All members of staff were friendly and polite even at the end of a long day (I picked the car up at 6.30pm). Highly recommended garage
Excellent job. Will use again. Highly recommended.
Disappointing, After receiving a long very reassuring reply to my ad that Millers could diagnose and normally repair 24hrs after, I booked my car in 5 days later at 9am garage said needed for 2hrs, I arrived at 8:30am & came back at 11:30am apparently some confusion in garage as they thought that they had my car all day. I waited another few hours. Car diagnosed as turbo failure I asked for a quote to replace turbo, I was told I would have quote by email in a few hours, at 5pm I called again I was told I would have a quote by 6:30pm no quote given the garage have not contacted me since. They left me searching for a different company to undertake the work and with a car off the road. I ended up back at main dealer where I should have gone in the first place. I believe this review to be fair and find it unacceptable to forgotten about & left stranded
Asked for a few extra things to be done and had some extras also fitted/replaced to help pass MOT hence variation in final price. All in all, extremely satisfied with the service - great price considering the amount of work done! Marian was very helpful and easy to talk to. Would highly recommend.
Very Nice work and very helpful mechanics. Will come back for sure
Excellent work, very helpful staff
The service offered seemed fine and was done on the same day.
Friendly independant garage. Carried out a thorough checks on the air con before commencing repairs. Fairly priced with good service. I would recommend this garage.
Great job!
Absolutely brilliant, would use again!


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Note: This item is more than 13 years old. Please take the publication date into consideration for any date references.
Print – Plain Text – Permalink
News Release
Media Contact: TPWD News, email@example.com, 512-389-8030
Sept. 20, 2004
Texas Kids Headed to Parks and Wildlife Expo
AUSTIN, Texas — Hundreds of young people from cities across Texas will board buses for the 13th annual Texas Parks and Wildlife Expo here on Oct. 2-3.
"We are going to be able to help hundreds of deserving youngsters come to the Texas Parks and Wildlife Expo, kids who might not otherwise get the chance to learn about outdoor sports and recreation opportunities," said Peter M. Holt, Texas Parks and Wildlife Commission member from San Antonio, who is also chairman of this year's Expo advisory board.
"Although these buses are already full with organized groups, including inner city young people that we are particularly trying to reach, we encourage other groups to organize on their own and come join us at Expo. For that matter, anyone is welcome to hop in the car and join the caravan to Austin for this free event on Oct. 2–3, " he said.
At this year's Expo, visitors of all ages will be able to try fishing, kayaking, shooting sports, rock climbing, mountain biking and more at no cost, with expert guidance and gear provided. The event runs 9 a.m.-5 p.m. on both Saturday and Sunday, and more than 40,000 are expected to attend.
Houston and San Antonio are sending the most youth on the buses. Ten Houston buses holding 55 people each will leave the morning of Oct. 2 and return home that night. San Antonio will also send 10 buses. Other cities sending young Expo-goers include Abilene, Beaumont, Brownsville, Copperas Cove, Huntsville, Prairie View, and Terrell.
Though the Expo itself is free, transportation and insurance create financial obstacles for many potential out-of-town visitors, thus the need to bus in kids who otherwise might not be able to go.
Because of high demand in participating cities, the TPWD-funded buses are already at capacity. However, several groups, such as AVANCE and the Phoenix Outreach Centers, are looking into providing their own transportation to Austin.
And also, at least six Community Outdoor Outreach Program grantees will be heading to the Expo. About 300 people from these groups will attend. The CO-OP program awards funding to tax-exempt organizations who introduce their participants to outdoor recreation, environmental and conservation programs.
Groups sending youths include Abilene Independent School District, America's Drug Free Production, Boys and Girls Scouts Clubs, Asian Chamber of Commerce, Huntsville Parks and Recreation, Prairie View A&M, Texas Southmost College, Turning POINT, Chatauqua Foundation, Houston Neighborhood Centers, Hester House, Christian Outdoor Coalition, Houston Independent School District, Buffalo Soldiers, Phoenix Outreach Centers, Barerra Group, and Houseman Group.
Dawn Bello, Urban Outreach Specialist emphasized that Texas Parks and Wildlife Department and its supporters are not always able to provide group transportation to Expo every year, but this year's effort represents the event's largest group transport program ever.
Major Expo sponsors this year include Anheuser-Busch, Toyota, Dow Chemical Company, La Invasora radio, Canon, HOLT CAT and Clear Channel radio in Austin. Other sponsors include Academy Sports and Outdoors, Mossy Oak Apparel Company, Winchester Ammunition, ChevronTexaco, Careco Multimedia, Inc., Sportsman's Warehouse, Weyerhaeuser, Weatherby Foundation International, Boone & Crockett Club, Gary Grant Sales, Inc., Omni Austin Hotel-Southpark, Shikar Safari Club International Foundation, Arby's of Central Texas, National Shooting Sports Foundation, CEMEX and Austin Coca-Cola Bottling Company.
Out-of-towners looking for a place to stay during Expo can call the Austin Convention and Visitor's Bureau at (512) 478-0098 for hotel and motel information.
To make reservations at a Central Texas state park, call (512) 389-8900 or book online (http://tpwd.texas.gov/park/admin/res/). For more information about Expo, including maps and directions, visit the Web site (http://tpwd.texas.gov/expo/) or call (800) 792-1112.
Publication — Permission is granted to publish, in whole or in part, any news releases on this page.
Print — A print-friendly version of the news release shows only the release with font sizes set to the browser default.
Plain Text — Plain text versions of TPWD news releases are provided for copying and pasting into editing software.
To copy text into an editing software:
- Click a Plain Text link to display the plain text page in your browser.
- Select all.
- Copy.
- Paste in a document in your editing program.
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If you have any suggestions for improving these pages, send an e-mail to email@example.com and mention Plain Text Pages.
(5.4.16 i)


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Olympus RING COVER (WC931900)Item#: 40349202 | Model#: WC931900
- Price:
- $.99
- Shipping:
- Temporarily out of stock. Order today and we'll deliver when available. (Details)
Olympus RING COVER Product Details
Manufactured by: Olympus
Warranty provided by: Olympus
UPC No:
Mfg Part No: WC931900
Box Size:
( Length:0, Width:0, Depth:0)
Shipping Weight: 0.0100 pound(s)
Click here for full warranty and support information
- Olympus logos are registered trademarks of Olympus. All others trademarks and copyrights mentioned herein are the property of their respective owners.


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A few weeks ago, we asked some of our favorite blog writers and friends from Facebook and Twitter to write some guest posts for us to help us through our busy season as we gear up for the 2010 Golden Spurtle Competition and our 2010 Cyclocross Season. This post is our first installment of guest posts and was written by Stacy Goldberg, MPH, RN, BSN who operates A Weigh of Life Nutrition and What's In Your Cart?, a two-part system for nutritional analysis and health assessment, how to shop for the best products for you and apply the principles of healthy eating to your life. For more information, please visit her website at aweighoflifenutrition.com. We hope you enjoy her recipe!
This delicious fall favorite packs a nutritional powerhouse and is a great Halloween or Thanksgiving treat! Packed with dietary fiber, protein, omega fatty acids, beta carotene and not to mention flavor…it is a delightful alternative for breakfast or a quick snack for the whole family to enjoy. Bob's Red Mill Gluten Free All Purpose Baking Flour can be a substitution for the Whole Wheat Pastry Flour.
- Non stick Grapeseed oil cooking spray
- 1/2 cup Dried Plum Puree
- 1/2 cup unsweetened applesauce
- 1/2 cup Bob's Red Mill Brown Sugar
- 2 large organic, cage free brown eggs
- 1/2 cup organic canned pumpkin
- 1 1/3 cup Bob's Red Mill Organic Whole Wheat Pastry Flour (100% stoneground, high fiber)
- 1/4 cup Bob's Red Mill Ground Flaxseed Meal (rich source of Omega 3 fatty acids)
- 1 teaspoon Bob's Red Mill Baking Powder (no aluminum)
- 1/2 teaspoon Bob's Red Mill Baking Soda
- 1/2 teaspoon cinnamon
- 1/4 teaspoon Bob's Red Mill Sea Salt (no additives)
- 1/4 teaspoon ground cloves
- 1/8 teaspoon ground ginger
- 1/8 teaspoon nutmeg
Serves: 16
Cooking Time: Over one hour
Heat oven to 350 degrees F. Lightly coat 8 1/2 X 4 1/2 inch loaf pan with cooking spray; set aside. In large bowl, blend Dried Plum Puree with sugars. DRIED PLUM PUREE: 2/3 cup pitted dried plums blended with 3 tablespoons HOT water. Beat in eggs and pumpkin just to blend. In medium bowl, combine flour, baking powder, baking soda, cinnamon, salt, cloves, ginger and nutmeg. Add to dried plum mixture, mixing just until moistened. Spread batter in pans; dividing equally. Bake in center of oven about 1 hour or until wooden pick inserted in center comes out clean. Cool in pan 10 minutes. Turn onto rack to cool completely. Bread can be wrapped tightly in foil and frozen up to 1 month, so make a double batch!
Recipe by Stacy Goldberg, MPH, RN, BSN of A Weigh of Life Nutrition and What's In Your Cart?


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OK, I'm officially smitten. It's as straight as the old IONs, but more HSS, so tolerates wind and OAT better (it's harder to turn than my new clear DGR IONs). The glide is very nice, the speed also, and I don't think I've ever dialed in this quick with a disc before.
Simply put, it's everything I fell in love with with the old IONs with added distance and reliability.


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Birmingham gritting alert – Dec 5
Precautionary treatment of all routes from 18:00.
Winter maintenance and gritting plans – http://birminghamnewsroom.com/?p=5746
Winter weather travel tips – http://birminghamnewsroom.com/?p=14233
Local volunteers from the Open Street Map project have kindly mapped gritting routes onto their map. While we can accept no liability for any errors, we're very grateful to them for their contribution.
You can view the gritting map by visiting: http://mappa-mercia.org/gritting-map.shtml
Weather Updates
BBC: http://news.bbc.co.uk/weather/forecast/2102
Met Office: http://www.metoffice.gov.uk/weather/uk/wm/wm_forecast_weather.html


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The National Wildlife Federation is the nation's largest member-supported conservation organization. We are committed to reconnecting people with nature, and we inspire Americans to protect wildlife for our children's future.
Feel the Difference in Working at the National Wildlife Federation
Our organization is filled with caring, committed individuals interested in the future of our environment. Our employees support each other's work in an atmosphere of trust and partnership. Our workspaces are flooded with light, creating a welcoming atmosphere. At NWF, you'll experience a spirit that will motivate and inspire you.
The most valuable assets in achieving our mission are our employees, who exemplify our core values of communication, collaboration and teamwork. We promote growth and creativity; our environment is one of employee and workplace safety, dignity and respect, corporate social responsibility and positive employee morale.
Inventiveness is one of the hallmarks of NWF; we promote a healthy work/life balance to create time for family/friends and connecting with nature. Our environment supports innovation and professionalism, and we ardently support individual talents.
NWF gives people the knowledge, the ideas, the tools and the power to make a difference. At NWF you'll find even more than a job; it's a lifestyle you'll enjoy.
We aspire to be an inclusive multi-cultural organization that celebrates the rich dimensions of diversity such as race, ethnicity, gender identity, sexual orientation, socio-economic status, age, physical abilities, religious and political beliefs. Diversity creates an awareness of and acknowledges respect for differences. Diversity at NWF translates into understanding and valuing each other's perspectives.
Why is diversity important to NWF?
Clean air, clean water and abundant wildlife sustain Americans from all walks of life. We share a responsibility to protect these public assets for our children's future. Just as a diversity of animals and plants are essential to a healthy ecosystem, NWF derives its strength and relevance from bringing together diverse people to create healthy communities for all.
Read NWF's strategic plan, A Plan to Repower America's Conservation Movement.


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Rare Kidney Stone Consortium Biobank
This study is currently recruiting participants.
Verified August 2017 by Dawn S. Milliner, M.D., Mayo Clinic
Mayo Clinic
Information provided by (Responsible Party):
Dawn S. Milliner, M.D., Mayo Clinic
ClinicalTrials.gov Identifier:
First received: December 30, 2013
Last updated: August 3, 2017
Last verified: August 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Biospecimen Retention: Samples With DNA
Detailed Description:
This study is being done to obtain samples from patients with primary hyperoxaluria, cystinuria, adenine phosphoribosyl transferase (APRT) deficiency, and Dent disease, and from their family members, for use in future research.
|Primary Hyperoxaluria Dent Disease APRT Deficiency Cystinuria
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Rare Kidney Stone Consortium Biobank, Rare Diseases Clinical Research Network
Resource links provided by NLM:
Genetics Home Reference related topics: Dent disease adenine phosphoribosyltransferase deficiency cystinuria primary hyperoxaluria
MedlinePlus related topics: Kidney Stones
Genetic and Rare Diseases Information Center resources: Primary Hyperoxaluria Type 1 Cystinuria Dent Disease Adenine Phosphoribosyltransferase Deficiency DihydroxyadeninuriaU.S. FDA Resources
Further study details as provided by Dawn S. Milliner, M.D., Mayo Clinic:
Primary Outcome Measures:
- Number of samples stored in tissue bank [ Time Frame: 4 years ]
Biospecimen Retention: Samples With DNA
Urine, blood and tissue samples
|Estimated Enrollment:
|Study Start Date:
|May 2013
|Estimated Study Completion Date:
|June 2020
|Estimated Primary Completion Date:
|June 2020 (Final data collection date for primary outcome measure)
Primary Hyperoxaluria
Diagnosis of Primary Hyperoxaluria, or a family member of someone with this diagnosis.
Dent Disease
Diagnosis of Dent Disease, or a family member of someone with this diagnosis.
Diagnosis of Cystinuria, or a family member of someone with this diagnosis.
APRT deficiency
Diagnosis of APRT Deficiency, or a family member of someone with this diagnosis.
Detailed Description:
Biologic samples will be stored in the biobank from well characterized patients with primary hyperoxaluria, cystinuria, APRT deficiency, and Dent disease, and from their family members, for use in future research. This will help to advance our understanding of disease expression and the factors associated with kidney injury in these four diseases with the overall goal of developing new treatments to preserve kidney function and reduce nephrocalcinosis and stone formation.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
Individuals with a confirmed Diagnosis of Primary Hyperoxaluria, Dent Disease, APRT deficiency or Cystinuria. Family members of individuals with these four diseases.
Inclusion Criteria:
Diagnosis of primary hyperoxaluria (PH) meeting one or more of the following criteria:
- Liver biopsy documenting alanine-glyoxylate aminotransferase (AGT) activity below the normal reference range confirming PH type 1 OR Liver biopsy documenting glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) activity below the normal reference range confirming PH type 2
- Molecular genetic analysis (DNA testing) confirming mutations known to cause PH type 1, PH type 2, or PH type 3
- Urinary oxalate excretion of greater than 0.8 mmol/1.73 m2/day (>70 mg/1.73 m2/day) in the absence of a identifiable causes of secondary hyperoxaluria, including gastrointestinal disease known to cause enteric hyperoxaluria
- A patient in end stage kidney failure, in whom neither a liver biopsy nor mutational analysis are available must have: (a) A plasma oxalate concentration of greater than 60 umol/L and a kidney biopsy confirming extensive oxalate deposits OR (b) Evidence of systemic oxalosis
- Participants in the previous protocol "Tissue Bank of Urine, Blood, and Tissue Samples Collected from the Patients with Primary Hyperoxaluria" 'Mayo IRB #' #80-04. They have already consented to bank their samples and that consent will serve to enroll them in this study.
Diagnosis of Dent disease meeting one or more of the following criteria:
- Identified mutation of the gene that encodes for chloride exchange transporter 5 (CLCN5)
- Low molecular weight proteinuria and hypercalciuria
- Low molecular weight proteinuria and nephrocalcinosis
Diagnosis of APRT disease meeting one or more of the following criteria:
- Suspected dihydroxyadeninuria and absent APRT enzyme activity measured in red blood cells (RBCs).
- Homozygosity, or compound heterozygosity, for known disease-causing APRT mutations.
- Passage of dihydroxyadenine stones (confirmed with stone analysis).
Diagnosis of Cystinuria meeting one or more of the following criteria:
- Stone analysis demonstrating that the stone contains cystine
- Increased urinary cystine excretion (>250 mg/gm creatinine)
- Relative of someone with confirmed primary hyperoxaluria, Dent disease, APRT deficiency (also known as dihydroxyadeninuria), or cystinuria
Exclusion Criteria:
- Stone formers who do not meet the inclusion criteria for primary hyperoxaluria, cystinuria, Dent disease, or APRT deficiency.
- Unwilling or unable to provide consent/assent.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02026388
Please refer to this study by its ClinicalTrials.gov identifier: NCT02026388
|Contact: Alicia M Meek
|Contact: Barbara M Seide
|United States, Minnesota
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|Contact: Alicia M Meek 507-255-4347 firstname.lastname@example.com
|Contact: Barbara M Seide 507-255-0387 firstname.lastname@example.com
|Principal Investigator: Dawn S Milliner, M.D.
Sponsors and Collaborators
Mayo Clinic
|Principal Investigator:
|Dawn S Milliner, M.D.
|Mayo Clinic
More Information
Additional Information:
Keywords provided by Dawn S. Milliner, M.D., Mayo Clinic:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
|Responsible Party:
|Dawn S. Milliner, M.D., M.D., Mayo Clinic
|ClinicalTrials.gov Identifier:
|NCT02026388 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 30, 2013
|Last Updated:
|August 3, 2017
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Plan Description:
|Biospecimens repository only. No individual data available to share.
Keywords provided by Dawn S. Milliner, M.D., Mayo Clinic:
Primary Hyperoxaluria Type 2
primary hyperoxaluria
primary oxalosis
Primary Hyperoxaluria Type 1
Primary Hyperoxaluria Type 3
Dent Disease
Dent 1
Dent 2
APRT deficiency
Additional relevant MeSH terms:
Kidney Calculi
Hyperoxaluria, Primary
Dent Disease
Kidney Diseases
Urologic Diseases
Urinary Calculi
Pathological Conditions, Anatomical
Carbohydrate Metabolism, Inborn Errors
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Metabolic Diseases
Renal Tubular Transport, Inborn Errors
Genetic Diseases, X-Linked
Renal Aminoacidurias
ClinicalTrials.gov processed this record on September 21, 2017


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CARERS across Worcestershire are invited to an event to find out what support, help and advice is available to them.
Hosted by Worcestershire Association of Carers, Redditch Carers Careline and Redditch Council, the event is themed 'Money Matters'.
There will be numerous stands from a wide range of organisations that provide support to carers, along with one-to-one benefits advice sessions, group talks and information sessions.
There are an estimated 60,000 informal Worcestershire carers with many caring for more than 50 hours a week for friends or relatives with a serious illness or disability. The Carers Rights Event aims to provide support, help and advice to carers, particularly financial and legal support.
Redditch mayor Alan Mason, who will be opening the event, said: "As a carer myself I feel this event will provide a great service to many people who may not know who or where they can go for help.
"When looking after someone else your own problems tend to get set aside to focus on those of the person you're caring for and often this can lead to more difficulties, whether financial or otherwise.
"This event will provide carers with the help and guidance they need so they can continue to provide help, guidance and care for others."
In anticipation of the Welfare Reform Act 2012, carers are invited to attend the event which will be held in the Civic Suite at Redditch Town Hall on Friday, December 7, from 10am until 4pm.
The event, including refreshments and speakers, is completely free.
To attend a talk for one-to-one advice at the event, call James Harris on 01905 751348 to book a place.


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It's picture day in steampunk Gotham City, and Batman brought his whole family to get their photos taken! He even took along his pals Zatanna and Wonder Woman, and also a few members of his rogue's gallery (Steampunk Batman is very polite).
These incredible cosplayers were photographed at last year's SDCC by Mike Rollerson; check out more of his incredible cosplay photos here.
[Via Fashionably Geek and Geeks Are Sexy]


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I often joke on this blog that the vintage and vintage sounding pro-audio equipment is actually helping me build a time machine to the 80s. While I'm in love with modern times (internet, iPads) I hold the 80s in high regard as the decade man decided to come to the future. The electronic music scene was full of originality. Most of the bands I listened to in 1987 sounded quite different from each other. Of course this must have to do with my age. Or is it something else? Simon Reynolds new book Retromania which will be released on July 19th holds a mirror up to society and asks if we have run out of ideas. Do you think we have?
"We live in a pop age gone loco for retro and crazy for commemoration. Band re-formations and reunion tours, expanded reissues of classic albums and outtake-crammed box sets, remakes and sequels, tribute albums and mash-ups . . . But what happens when we run out of past? Are we heading toward a sort of culturalecological catastrophe where the archival stream of pop history has been exhausted?
Simon Reynolds, one of the finest music writers of his generation, argues that we have indeed reached a tipping point, and that although earlier eras had their own obsessions with antiquity—the Renaissance with its admiration for Roman and Greek classicism, the Gothic movement's invocations of medievalism—never has there been a society so obsessed with the cultural artifacts of its own immediate past. Retromania is the first book to examine the retro industry and ask the question: Is this retromania a death knell for any originality and distinctiveness of our own?"
For more info: Retromania at Amazon.com