text:
Broccoli Sprout Extract in Treating Patients With Transitional Cell Bladder Cancer Undergoing Surgery
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Rationale: Broccoli sprout extract contains ingredients that may prevent or slow the growth of certain cancers.
Purpose: This pilot study is studying the side effects of broccoli sprout extract in treating patients with transitional cell bladder cancer undergoing surgery.
|Recurrent Bladder Cancer Stage 0 Bladder Cancer Stage I Bladder Cancer Stage II Bladder Cancer Transitional Cell Carcinoma of the Bladder
|Drug: broccoli sprout extract Other: laboratory biomarker analysis Other: Mango Juice
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Pilot Pre-cystectomy Trial of Broccoli Extract in Patients With Superficial or Locally Advanced Bladder Cancer
- Toxicity as Assessed by National Cancer Institute (NCI) Common Toxicity Criteria Version 3.0 [ Time Frame: 14 days ]Number of participants with an adverse event.
- Apoptosis, Cell Proliferation, and Microvessel Density [ Time Frame: 1 year ]
|Study Start Date:
|April 2010
|Study Completion Date:
|October 2015
|Primary Completion Date:
|September 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm I
Patients receive oral broccoli sprout extract once daily on days 1-14 in the absence of disease progression or unacceptable toxicity.
Drug: broccoli sprout extract
Given orallyOther: laboratory biomarker analysis
Correlative studies
Placebo Comparator: Arm 2
Patients receive mango juice alone.
Other: Mango Juice
given orally
Detailed Description:
Primary Objectives:
I. To determine the tolerability and toxicity of a broccoli sprout extract (providing 200 micro mol isothiocyanate/dose/per day) given for 14 days in patients destined to undergo definitive bladder resection for bladder cancer.
Secondary Objectives:
I. Establish the safety of administration of the broccoli extract on the bladder surgery specifically.
II. Determine the levels of isothiocyanates and their metabolites in urine, blood, benign urothelium and bladder cancer tissue.
III. Assess the antitumor effects of broccoli extract on the primary bladder tumor by measuring angiogenesis, cell proliferation and apoptosis.
IV. Determine the feasibility of treating patients with 200 micro mol isothiocyanate per dose per day of broccoli sprout extract in future therapeutic and prevention clinical trials.
Outline: Patients receive oral broccoli sprout extract once daily on days 1-14 in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed at 4 weeks.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Any patient eligible for superficial bladder cancer
- Patients must be considered fit for surgical resection with curative intent
- No chemotherapy, surgery (excluding transurethral resection of bladder tumor [TURBT], BCG or radiotherapy in the prior 4 weeks [6 weeks for mitomycin C or interferon])
- No previous treatment/ingestion with broccoli extracts
- Eastern Oncology Group (ECOG) performance status 0-2
- AST and ALT =< 2.5 times ULN (upper limit of normal)
- Total bilirubin =< 2.0 mg/dL
- Creatinine Clearance >= 30 ml/min
- WBC > 3000 mm^3
- Absolute neutrophil count > 1000/mm^3
- Platelets > 100,000/mm^3
- All patients must sign a study-specific consent form indicating that they are aware of the investigational nature of this study
Exclusion Criteria:
- Have participated in any clinical trial involving conventional or investigational drugs or devices within the previous 4 weeks
- Prior radiation to the pelvis
- Intractable urinary tract infection that has not responded to antibiotic treatment
- Active, uncontrolled bacterial, viral, or fungal infection including HIV
- Have had major surgery within 4 weeks of starting therapy (not including placement of vascular access device or TURBT)
- Poor medical risk in the opinion of the treating oncologist due to non-malignant systemic disease
- Pregnant or lactating patients: patients must be postmenopausal or practicing an accepted form of birth control; for patients where pregnancy is a possibility, a pregnancy test will be required prior to initiation of therapy
- Have a history of myocardial infarction or angina pectoris/angina equivalent in the last 6 months (the patient may be on anti-anginal medications if the symptoms have been entirely controlled for greater than 6 months), or have uncontrolled congestive heart failure
- Have a history of bleeding disorders or thrombosis; patients on therapeutic doses of anticoagulation (including coumadin or heparins) are not permitted on trial (this exclusion criterion does not include those patients receiving low dose or prophylactic dose anticoagulation [i.e. coumadin 1 mg daily in patients with central intravenous lines])
- Radiotherapy during the course of the trial
- Inability to tolerate proposed treatment or procedures
- Have additional uncontrolled serious medical conditions or psychiatric illness
- Patients with a history of hepatitis (including but not exclusive to viral hepatitis auto-immune or alcoholic)
- Patients with active thyroid disease (patients with hypothyroidism, adequately replaced on a stable dose of thyroid replacement will be allowed on trial)
Please refer to this study by its ClinicalTrials.gov identifier: NCT01108003
|United States, New York
|Roswell Park Cancer Institute
|Buffalo, New York, United States, 14263
|Principal Investigator:
|James Marshall, PhD
|Roswell Park Cancer Institute
|Responsible Party:
|Roswell Park Cancer Institute
|ClinicalTrials.gov Identifier:
|NCT01108003 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 19, 2010
|Results First Received:
|May 16, 2016
|Last Updated:
|May 31, 2017
Additional relevant MeSH terms:
Urinary Bladder Neoplasms
Carcinoma, Transitional Cell
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Urinary Bladder Diseases
Urologic Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
ClinicalTrials.gov processed this record on September 21, 2017


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Dublin Ministerial Conference (2003)
On 16-17 October 2003, Ministers and government representatives of the Pompidou Group's Member States and
representatives of the European Commission met in Dublin, Ireland.
The Conference dealt with the general theme: "New Challenges for Drug Policy in Europe".
The Conference adopted a Statement on the Structure and Working methods of the Pompidou Group, enshrining certain amendments made to the "Modernisation report" adopted at the Sintra Ministerial Conference in 2000, as well as the Work Programme 2004-2006 of the Pompidou Group.
The XIII Ministerial Conference of the Group marked the end of the Irish presidency (1997-2000) and the beginning of the Dutch presidency for the period 2003-2006.
Photo gallery of the Conference

subset: commoncrawl


text:
For many children, allergies and asthma stand to get in the way of having a fun, productive school year. But if properly controlled, asthma and allergies should not interfere with your child's activities, school, or life.
Allergic rhinitis (also called "hay fever") is caused by an aggressive immune system response to everyday substances that are normally harmless. It affects 40 million Americans, causing symptoms such as a stuffy, runny, or itchy nose; sneezing; coughing; and itchy or watery eyes.
Asthma is a breathing problem affecting nearly 5 million children in the United States. It is caused by a swelling of the airways, which leads to coughing, wheezing, shortness of breath, and chest pain or tightness.
If uncontrolled, these conditions can limit the activities a child can participate in, as well as her ability to feel well and be alert in school. They can even cause a life-threatening reaction that requires emergency treatment. Allergies and asthma are often triggered by the same allergens and irritants, including:
Limiting your child's exposure to these allergens can help reduce and may even prevent allergic reactions and asthma attacks.
While you can't make your child's world 100 percent allergen-free, you can help her identify and avoid the triggers that cause her to feel sick. The following tips may help:
For more information on allergies and asthma, visit the section on Allergy and Immunology at the AAP's Web site at www.aap.org/sections/allergy.
This article was featured in Healthy Children Magazine. To view the full issue, click here.


text:
I can't seem to log into the wiki, it just complains I have the wrong password. Any ideas?
It works for me, at least.
Are you sure you're putting in the same password as you have for the forums?
Hmm I just signed up again, and this account seems to work fine


text: Advance your career and gain new skills with training courses coupons! Grab a great coupon for training courses today and enjoy offers of 50% or more on enrollment into a local Johannesburg training courses offering from universities or colleges. With many people looking to gain new qualifications, training courses offerings from many Johannesburg institutions are now more flexible than ever, with online and part-time options available.


text:
Roc Lover wrote:jsun3thousand wrote:Jeronimo wrote:jsun3thousand wrote:go play blue valley in kansas city. it will teach you a thing or two.
it's one of the longest permanent courses in the country ranging between 9297 ft. – 11049 ft. it's up and down monster hills all day long. you're looking at a 3+ hour long round and you won't see another group the entire time. blue valley is more about the experience than anything. the tee pads are awesome because they are massive and shaped like the hole. you play blue valley for fun once a year and for tournaments. if you have the 09 world's dvd the final 9 features holes 1,2, and 3 from blue valley then the over the pond hole is a temp, then it's the baby course until the 9th hole. play it when the weather is nice because it's not fun in the heat or the wind.
ITs a very long course, fun to play every now and then, on a daily basis, not so much
Sounds kinda like Maple Hill.


text:
In November 2012 I started replacing all CFL and Incandescent lighting in the home with new LED bulbs. At our local 'big box' home improvement store I purchased several (35) LED bulbs and began making the switch to LEDs. Over the past several years most of our incandescent lights had been replaced with CFLs. I was not happy with the performance of the CFLs both in terms of light quality and life of the bulb. It seems like every other month I was…Continue
Added by Dale Stephens on December 11, 2012 at 6:30am — 6 Comments
© 2017 Created by Lawrence Berkeley National Laboratory. Powered by


text:
Wednesday, August 6, 2014 - 12:15
The Lotus Elise has beaten the Alfa Romeo 4C yet again in the latest comparison test by Sport Auto in France.
The August issue of France's widest-read sports car magazine rates the Elise S Club Racer for its ride and handling, as well as its "delightful simplicity", preferring it to the Alfa Romeo, stating "the most simple recipes are the best". Sport Auto also praises the Elise S as a "reassuring and easy to understand sports car, whose performance delivers the pure driving experience sports car fans love." The magazine also comments that the Lotus is "easy to live with" and is "a real pleasure to drive".
This is the third comparison test the Elise S has won against the Alfa Romeo 4C, recently beating the Italian car in German magazine AutoBild and Dutch magazine AutoWeek.


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IEEE Power & Energy Society Announces 2012 Scholarship Recipients
28 November 2012 – The IEEE Power & Energy Society Scholarship Plus Initiative (IEEE PES S+) recently announced scholarship distribution to 228 students at 100 universities across the United States for the 2012–13 academic year.
The IEEE PES S+ provides multi-year scholarships to qualifying US Electrical Engineering undergraduate students. Scholars receive up to three years of funding—US$2,000 the first year, US$2,000 the second year, and US$3,000 the third year—interspersed with up to two years of valuable, hands-on career experience.
"The IEEE PES S+ is one way we are helping support the next generation of power leaders," said IEEE Fellow Wanda Reder, co-chair of the scholarship. "These are exceptional young men and women who are excited about power and the opportunities in the field."
The program, made possible by donations to the IEEE Power & Energy Society Scholarship Fund of the IEEE Foundation, is in its second year. The IEEE PES S+ has supported a total of 265 scholars attending 109 universities, including Ivy League colleges, flagship state universities, and prestigious engineering colleges across the US. The program has provided $642,000 in scholarships and has raised $4.1 million in cash and pledges from donors to the program, nearing the halfway point to its $10-million fundraising goal.
"Executives across the power and energy industries share a concern for the pipeline of talent entering the power engineering workforce especially as more and more of the baby boomers, who built today's power system to its present strength, prepare to retire," stated Reder. Over the next decade, almost 62 percent of the industry has the potential to retire or leave the field for other reasons.
View a full list of the 2012 PES Scholarship recipients
Two industry leaders have shown their support of the program through their respective $1-million donations: S&C Foundation, which is affiliated with S&C Electric Company, and Schweitzer Engineering Laboratories. Other prominent supporters include The Grainger Foundation, Alstom, Doble Engineering, Powell Industries, Cooper Power Systems, Southern California Edison, ISO New England, Autodesk, PSE&G, Ulteig, Westinghouse, MidAmerican Energy Foundation, NSTAR, PJM Interconnection, and GE Foundation.
Francine Tardo
+1 732 465 5865
Monika Stickel
+1 732 562 6027


text:
Adjustable Plant Hanger
This item is currently not available.
Additional Information
Turn Almost Any Pot into a Hanging Planter
- Simple design and clean lines showcases a potted plant
- Sturdy steel supports heavy plants
- Adjusts to fit most pots
This innovation lets you create a hanging planter from most pots with a base diameter larger than 3". It automatically adjusts to fit a symmetrically shaped pot and holds it securely. Includes weatherproof nylon hanging cord.
Product Details
- Welded steel, nylon cord
- 31" H overall (including hanging cord)
- Base is 3" square
- Side supports are 7" H
REVIEW SNAPSHOT®by PowerReviews
Best Uses
- Was this a gift?:
- No (4)
Reviewed by 4 customers
- Attractive
- Versatile
Best Uses
- Use On Plant Hook Stand
I was concerned that the hanger would be too long for the closer-to-the-ground hook on my dual-hook stand. It is not. Previously, I bought pre-made hanging baskets in unattractive pots with unattractive attached hangers. I like the flexibility I have now of changing out pots of flowers that I insert into attractive outer pots.
- Was this a gift?:
- No
- Simple to use
Best Uses
Love this product. Easy to use.
- Was this a gift?:
- No
- Catches On The Window
- Doesn't Move Easily
- Metal Framework Awkward
Best Uses
Catches on a double-hung window - raising or lowering the window is awkward. To move your plant, you have to rempve the pot from the hanger completely and the metal frame is awkward to work with.
- Was this a gift?:
- No
I love this planter, it adapts to square or round containers. I used a mix of spider plants and flowering plants in my basket, it's beautiful!
- Was this a gift?:
- No


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Commemorations of Jamestown's 400th Anniversary
Fairfax County Office of Public Affairs
12000 Government Center Parkway, Suite 551
Fairfax, VA 22035-0065
Contact: Merni Fitzgerald, Director of Public Affairs
703-324-3187, TTY 711, Fax 703-324-2010
Media Pager: 703-324-NEWS (6397)
Jan. 8, 2007
Fairfax County Begins Yearlong Commemorations of 400th Anniversary of Jamestown's Founding
Today at its regular meeting, the Fairfax County Board of Supervisors issued a proclamation urging residents to participate in the yearlong commemorations of the founding of Jamestown, Va., the first permanent English settlement in the Americas. This year marks the 400th anniversary of Jamestown's founding.
As an official Virginia 2007 Community, Fairfax County is participating in this year's statewide commemorations. To highlight the yearlong commemoration, the county's Virginia 2007 Community Citizen Planning Committee is:
- Publishing an anthology this spring that features historically significant events and stories that have taken place in Fairfax County during the past 400 years — since the settlement of Jamestown in 1607.
- Sponsoring 10 different public service announcements about historically significant people and places in Fairfax County during the past 400 years. These PSAs are being cablecast on Fairfax County Government Channel 16 now through December. To view the PSAs, visit www.fairfaxcounty.gov/opa/va2007, or watch Channel 16 throughout this year.
- Displaying "Uncovering Home: A Visual Essay of Jamestown Archaeology," an exhibit from the Virginia Museum of Fine Arts, from Jan. 8 to 12 in the Fairfax County Government Center lobby, 12000 Government Center Parkway, Fairfax.
- Encouraging all public and private property owners to plant an "Anniversary Garden," with a red-white-and-blue theme. For more information, suggested garden designs or tips, visit www.ext.vt.edu/americasgarden, or call the Virginia Polytechnic Institute and State University Department of Horticulture at 540-231-7906, TTY 711.
The committee encourages, promotes and publicizes events taking place in the county that commemorate the 400th anniversary of the settlement of Jamestown. A listing of 2007 commemorative events taking place in Fairfax County can be found online at www.fxva.com.
Organizations that wish to sponsor a 2007 event should contact the Fairfax County Office of Public Affairs, which also can provide a list of monthly commemorative themes.
Appointed by the Fairfax County Board of Supervisors, the committee represents the diversity of communities and resources in the county, including the African-American, Asian-American, Hispanic and American Indian communities and representatives from Fort Belvoir, Wolf Trap, George Washington's Mount Vernon and the Fairfax County Convention and Visitors Corporation.
To sponsor a 2007 event or for more information about Fairfax County's 2007 program, contact the Office of Public Affairs at 703-324-3187, TTY 711, or visit www.fairfaxcounty.gov/opa/va2007. For more information about Jamestown 2007 and the Virginia 2007 program, visit www.americas400thanniversary.org.
For more news and information, visit www.fairfaxcounty.gov/news.


text:
THE Bridgwater & District Summer Skittles League drew to a close this week and the winners of the divisions are decided.
Prizewinners are: Men: Early Winners – Riff Raff; Runners-up – Daydreamers.
Main Winners – Birdies; Runners-up – Pawlett Pins.
Premier Winners – Gamblers; Runners-up – Matchmakers.
Mixed: Blondes Winners – Wild West; Runners-up – Rebellions.
Bluebell Winners – Radishes; Runners-up – Trumpeters.
Brunettes Winners – Mixed Bunch; Runnersup – Jack & Jills.
Cornhill Winners – Split Happens; Runners-up – Mansion House.
Ladies: Champions Winners – Patsy's Pussies; Runners-up – Cannon Girls.
Emeralds Winners – Twiglets; Runners-up – El Syd.
Pearls Winners – Generations; Runners-up – Global Girls.
Rubies Winners – Spares; Runners-up – Louby Lou's.
Entrants for the Highest Score Competition (Friday, September 5) are: Men's: John Froud (Fireworks 82 & 73 at Castle Club); Allan Cavill (Railway Six 78 at Castle Club); Phil Court (Split Happens 78 at Castle Club); Sam Dennison (Gentle Giants 74 at Lime Kiln); Richard Griffiths (Birdies 73 at Castle Club); Steve Cresswell (Jack & Jills 73 at Castle Club); Wayne Pither (Cannington Chemistry 73 at Sydenham Centre); Neil Perkins (Mixed Bunch 72 at New Foresters).
Reserves: Dave Winn (Choppers 72 at New Foresters); Chris Marks (Rebellions 72 at Squib).
Ladies: Alli Lazenby (Patsy's Pussies 72 at Castle Club); Rene Donnelly (Wotsits 69 at The Market); Claire Harris (Mothers Pride 69 at The Market); Avril Frost (Trumpeters 67 at Stockland Club); Mary Burge (Rebellions 67 at Squib); Mel Palmer (Munch Bunch 67 at Crown Inn); Becky Palmer (Split Happens 66 at Castle Club); Pauline Culverwell (Castlettes 65 at The Market).
Reserves: Claire Perry (Lambettes 63 at Stockland Club); Lindsey Parsons (Global Girls 63 at BARFC) Please can competitors inform the secretary if they are unable to attend the competition before September 5.
Highest Score Competition – Friday, September 5, at the Blake Arms at 7.30pm.
Presentation Evening – Friday, September 19, at the Castle Club.


text:
Join our newsletter for new products, special offers, and more!
Enter email address
Sell your stuff or turn those old games into new!
Don't see what you're looking for? Create a Want List!
Partner with the Knight!
Conquest Tactics is the next evolution of card games: a strategy card game. Gone are the days of relying on luck and hoping that cards are drawn in the correct order. In Conquest Tactics, strategy, skill, and knowledge of the capabilities of your troops will be vital to defeating your opponent. Every battle will be different, making the ability to adapt invaluable. If you have been looking for a strategy card game that's more exciting and challenging, Conquest Tactics is for you.


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MANAGER Dave Webb is looking forward to showing off everything that's good about Swindon Supermarine when they host Swindon Town this afternoon (kick-off 3pm).
Marine host the traditional friendly between the two clubs, having spent much of the summer making improvements to their Webb's Wood Stadium home, as well as working on the pitch.
Webb insisted the club are honoured to play host to the town's professional team and he is hoping for a bumper crowd to come through the doors to see what they have to offer.
"It's always a big one for us and a pleasure to play against Swindon Town," he said.
"There has been so much effort and time put in to get the ground ready over the summer and the work to get the pitch in such a good way is really great.
"Everything's in place to host Swindon Town now and I'm sure anyone who comes up to the club for the game will enjoy it."
Having lost the likes of Ash Edenborough and Josh Parsons this summer, Webb knows he has a rebuilding job to do but is looking forward to watching his team take on the Robins' professionals.
"This is a chance for the players to get things going and we've lost a few this summer, but we're working really hard to try and fill those gaps," he said.
"Our problem at the moment is that we also have a few injuries which makes things hard but the lads have had a good couple of weeks of preparation.
"The result isn't important but this is a good chance for people to come and watch two local teams.
"We'll have a decent team out and we will look to put in the best display we can."
Marine will be missing Mark Flanagan, Eddie Stephens and Sam Morris through injury this afternoon.


text:
Harold J. Burstein, MD, PhD
Associate Professor of Medicine, Harvard Medical School
Center/ProgramBreast Oncology
Office phone: 617-632-3800
Appointment phone: 617-632-2175 (new), 617-632-3800 (follow-up)
Fax: 617-632-1930
Email: email@example.com
Preferred contact method: email
Request an appointment
View Researcher Profile
Medical Oncology
Research Department
Dana-Farber Cancer Institute
450 Brookline Avenue
Boston, MA 02215
BiographyDr. Burstein graduated from Harvard College before earning his MD at Harvard Medical School. He also received a PhD in cellular immunology and a master's degree in the history of science from Harvard. He trained in internal medicine at Massachusetts General Hospital before his oncology fellowship at DFCI. In 1999, he joined the staff of DFCI and Brigham and Women's Hospital, where he is a clinician and clinical investigator in the Breast Oncology Center.
Board Certification
Medical Oncology, 2000
Internal Medicine, 1997
Dana-Farber Cancer Institute, Hematology/Oncology
Massachusetts General Hospital, Internal Medicine
Medical School
Harvard Medical School
Recent Awards
- George P. Canellos Award for Excellence in Clinical Investigation and Patient Care, 2001


text:
A's activate Rosales, send Parrino to Triple-A
OAKLAND -- Sporting a big smile and a clean bill of health, Adam Rosales was happy for the news Thursday.
The infielder was reinstated from the 15-day disabled list, the A's announced, and the club optioned Andy Parrino to Triple-A Sacramento.
Rosales started the season on the DL with a left intercostal strain and began his rehab assignment with Class A Stockton on April 17 before moving up to Sacramento on Sunday.
"I think we took the right path," Rosales said of his rehabilitation process. "The trainers helped me, they all did a great job. They made sure I stayed on the right track and did everything I needed to get back as soon as possible."
Rosales batted .320 with two doubles, a home run and an RBI in six rehab games. However, his return hinged more on his ability to throw without discomfort, and the team even checked in Thursday to ensure he was ready.
Before Thursday's 10-2 loss against the Orioles, manager Bob Melvin said Rosales would "probably" start Friday, but Rosales appeared earlier, pinch-hitting for Eric Sogard in the seventh inning with runners on first and second against reliever Troy Patton. Rosales grounded into a double play, but singled to right in the ninth inning.
Parrino hit .125 in nine games with Oakland. He started six games, four at second base, one at shortstop and one at third base.
Willie Bans is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text: Textbooks.com is the premier online destination dedicated to offering the best used and new textbooks at up to 90% off every day. In fact, no other bookstore sells more of the used textbooks students demand. Fast and free shipping, 50% cash back on 1000s of titles, premier customer service and more have made Textbooks.com the first choice for savvy college shoppers.


text:
For months, Edward and Richard anticipated the moment they would step off the plane into the hot Caribbean sunshine. Both Villa Specialists at Luxury Retreats, they knew their St Martin/St Barts vacation would be top-of-the-line everything, but it was the unexpected moments along the way that made a truly unforgettable experience.
Sitting down with their iPhones out excitedly reminiscing about a recent vacation they shared with four of their closest friends, Richard and Edward remember the adjustment from the bracing Montreal spring to the heavenly weather in St Martin, "We were blinded by the brightness", Edward says, "It remained that way for the whole trip–we didn't see a cloud for a week."
Arriving in St Martin from Montreal after a brief stop in JFK, the group was eager to settle in to Hacienda, perched atop a hill providing endless views of the Caribbean sea. "The first little while we just explored the property–it's so expansive we each had our own separate wing", notes Edward. The villa is a 4-bedroom, 3-bathroom estate decorated with contemporary furnishings and surrounded by lush greenery, conveniently situated only three minutes away from sunset hotspot Long Bay Beach. After settling in, next on the to-do list was to begin exploring the culinary delights of the island. Richard remembers the great first impression that Bamboo Bernie's sushi spot made, "The cosmopolitan cocktails were amazing, and we made a point to order different dishes from the menu so we could all try something new. Plus they had a live DJ spinning so we loved the ambiance."
"The yacht tour is an ideal day trip for travelers who love to socialize! Plus, we got to stop by Prickly Pear Island, to snorkel over the reef–it was magical"
Aside from exploring the island's foodie scene, the group also had fun on a yacht tour aboard the Aquamarine Tango, "We had to be there bright and early at 8:30am. We didn't know what to expect, but everything, from the Caribbean music, to the super friendly staff who encouraged everyone to relax and have fun, was far beyond what we could have asked for," notes Edward. Richard remembers how perfectly this activity matched their group, "The yacht tour is an ideal day trip for travelers who love to socialize! Plus, we got to stop by Prickly Pear Island near Anguilla, to snorkel over the reef–it was magical." This, with the oh-so-necessary lunch break on the beach in Anguilla, will make for a lasting memory.
After a day on the water, imagine cruising around in a soft-top jeep, watching the sun go down at Sunset Bar and dancing the night away at Sky Beach while the electric vibes of the St Martin Carnival provide even more excitement. And that was just the first half of the trip–on the fourth day of living it up in St Martin, the group hopped on the plane for a change of pace in St Barts.
"We loved having two distinct villa experiences–in St Martin, the Hacienda was expansive and ritzy, while Heloa was the epitome of cozy luxury"
"The St Barts leg of the trip was incredibly relaxing" says Richard. With one of the best views on the island and an upscale cozy cottage vibe, villa Heloa offered a totally different experience than the sprawling Hacienda. Edward describes Heloa as, "Nice and intimate; the property is nestled on the side of the mountain in a charming little neighborhood. We loved having two distinct villa experiences–in St Martin, the Hacienda was expansive and ritzy, while Heloa was the epitome of cozy luxury." Heloa's sun-drenched lounge chairs around the immaculately kept pool, looking out to the sparkling sea, were the perfect place to sip morning coffee.
The friends made a point of exploring all the legendary beaches on the island. "We really wanted to check out Colombier, Saline and Gouverneur," says Edward. "They were all stunning, but we enjoyed Saline Beach in particular. The water was immaculate and the temperature and waves made it perfect for swimming."
From endless hours on the beach to enjoying cocktails at the see-and-be-seen hotspot Nikki Beach; as the sunshine and good times continued, the trip seemed like it could last forever. Edward sums up the experience shared by all, "Once you taste this kind of travel, you never want to go back. Whatever you have in your imagination for a dream vacation, your fantasies can become a reality–and that reality is better than your fantasy."
Find out more about villa Heloa, St Barts
Find out more about Hacienda, St Martin


text:
Results 11 to 15 of 80
December 19th, 2012 11:53 PM #11Ashley | namenerd | Christian | storyteller
princesinhas e príncipes:
Isabelle Aurora Grace ▪ Adele Sofia Eloise ▪ Everett Joshua Charles ▪ Casper Nathaniel Eden
thinking about today:
Violet Fiala Elisabeth ▪ Daniel Torin Elijah ▪ Evangeline Dagny Hope ▪ Hugo Emerson Jack
Claire Everly ▪ Jack Jasper ▪ Delphina Lily "Della" ▪ Thomas Brynjar ▪ Hazel Isabella
Sebastian Malachi ▪ Katherine Aurora ▪ Grayson Amory ▪ Grace Amélie ▪ Reuben Sebastian
December 20th, 2012 12:10 AM #13Senior Member
- Join Date
- Apr 2012
- Location
- Posts
- 429
December 20th, 2012 02:04 AM #15Senior Member
- Join Date
- Sep 2012
- Posts
- 2,791
Hey there. Sorry about the nightmare! Who needs Faramir and Gawain when you've got Endymion and Herne anyway? I would think that narrowing the list down might make things easier once the baby's born, but I'm happy to keep playing with your list!
What's up with Alaric as a first name? Are you liking some of the middles more than the firsts?
Altair- I like the astronomical connection to Aquila. Soundwise, I prefer Alastair.. Altair sounds a lot like "alter," so it feels slightly ungrounded, transitional or something.
Artegal- I hear "article." Still, a very graceful name.
Cicero- Like Orpheus, a wonderful namesake but a one-man-name. Middle name material IMO.
Galileo- Again, a one-man-name, but so obviously so that it becomes more useable. I think Orpheus or Cicero would be hard to inhabit. Galileo is so over-the-top that it feels freer, if that makes any sense. Great sound too.
Hector- Sure! But it's pretty butch compared to your others. I recommend "Hector Protector," illustrated by Maurice Sendak.
Hermes- Love this. But not with Herne, unless they're twins, and even then it might be questionable.
Hylas- I'm torn. Part of me finds it lovely to say, kind of sexy and sleek, and part of me hears "high-less" ...my ears hang on the "less." But I feel the same way about Silas, and Silas is pretty much bulletproof.
Lorand/Roland- Lorand.. very interesting. I think you could name a son Roland and use Lorand as a nick. Love Roland. Well, I love The Song of Roland. The name is handsome, but not as handsome as Herne or Endymion.
Marinell- I think of marinara sauce.
Orville- Love this but I don't think it fits with your other names. I think of Orville and Wilbur Wright. I see Orville fitting in with those fashionably clunky, hobnailed, old-man, steampunk-Biblical type names like Barnabas, Gideon, Cornelius..
Ovid- I know I know, Ovid the poet. I just think "oviduct, ovary, ovulation."
Pelleas- I think it sounds a bit like "bilious."
Rodomante- I think about rats every time I take the subway. No name beginning with "Rod" and ending in "ante" will get my approval.
Seneca- Ok my grasp of ancient history is abysmal, so bear with me. Seneca as in Nero's advisor? Isn't Nero known as kind of a bad guy? "Nero fiddled as Rome burned" and all that? Plus, the Native American thing (though surely it's not as sensitive an issue in England.)
Tiberius- Love. Blade's old suggestion of Tiberius Heron has been floating around in my head since you dropped it. Knocked my socks off!
December 20th, 2012 03:37 AM #17Senior Member
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December 20th, 2012 03:38 AM #19Senior Member
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Oh and Galileo, I like that too.Eliza + Beatrix + Constance + Romilly + Clementine + Freya + Mabel + Agnes + Betty + Margot
Felix + Ivo + Calloway + Walter + Linus + Otto + August + Hugo + Zebedee + Rollo + Phineas


text:
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Last edited by Natston; 09-09-2012 at 04:01 PM.
Edit Signature
Wow...yet another ill - advised throw
I'd rather die standing up than live on my knees.
-Emiliano Zapata
Now we've got to suffer through even more of our so - called defense
I'd rather die standing up than live on my knees.
-Emiliano Zapata
I'm gonna be a little upset if we don't spend all of our picks for next year on lineman (on both sides).
The only thing worse for Colts fans (as for hearing questions of doubt about the current direction) would be Manning looking great tonight.
Colts look weak in the trenches. Luck has no time and has made questionable decisions as the score and clock has spiraled away. Meanwhile, RGIII has had a great game.
Nuntius was right for a while. I was wrong for a while. But ultimately I was right and Frank Vogel has been let go.
"A player who makes a team great is more valuable than a great player. Losing yourself in the group, for the good of the group, thats teamwork."
-John Wooden
I'm going to get more upset if people continue to judge this team based not only one game but one against a stacked team like the Bears.
Edit Signature
Luck has been really shaky on deep passes today. Take your lumps, kid.
Was that a case of not seeing the DB or just another underthrown INT?
I'd rather die standing up than live on my knees.
-Emiliano Zapata
That comparison between Manning and Luck's first start... that is jaw dropping.
Carmel HS Class of 2011
Hopefully he learns from today that was another horrible pass.
Growing pains galore, but there's always next week.
Luckily I missed the last one, because I was watching if the Saints were going to come back but instead it was Brees throwing an INT...
Edit Signature
I missed it, so I had to look up Manning's stats - 1 TD, 3 INT, 302 yds. I know it's only one game, but this did make me feel a little better.
This game got me thinking about how many years Bill Polian wasted at drafting? last 2 years? last 3?
Edit Signature
Why couldn't Tim Jennings play like that when he was here?!
For years as a Colt he was a total disappointment
As for the rest of the game it went like I figured it would well except at the beginning when the Colts first scored that I didn't think would happen but beyond that the rookie mistakes were to be expected.
I think Luck has the potential to be great but we also need to protect him and the O-Line is terrible he won't last long if this keeps up.
Just a side note. RG3 struggled against the Bears earlier in preseason
As i said during all the RG3 bashing earlier, unfair and a bit stupid to base any player based off one game. Nfl seasos is a marathon, not a sprint
Facebook friend took a picture - Manning was sacked 4 times in his debut game. Again, all of this is with a grain of salt.
Alright game over, I refrained from posting during the game, lotta knee-jerk reactions. Lots of points to make:
1) People may not have realized how dinged up we were. We went into that game with a bunch of guys out, and then we *lost* even more as the game went on. Hilton and Collie out hurt bad for us on offense.
2) Don't forget how many rookies we had out there on offense... Brazill, Fleener, Luck, Adams, Ballard... and we also have a number of low-experience 2nd-3rd year guys.
3) The Bears are good. They're a SB contender in my mind. They have a lot of pieces in place. Their defense is quality (better than the Saints, more on that).
4) Was a game on the road.
Now on to the actual game:
- Went as expected. Anyone expecting the Colts to win this game was a little off-base, imo. Would've been a real surprise had we won.
- Our O-Line immediately jumps out at needing work, which I expect they will. I sort of expected a bad showing today, but that unit should gel over the next weeks. They have plenty of motivation to improve and now some real game-tape to look at.
- Anyone who didn't know Joe Lefeged didn't watch last year, he was a good player on ST last year too. Not surprising at all he was making plays out there.
- The pass interference calls in the first half was ridiculous. How many did we have, 5-6? Some of them were very questionable. The rookie refs showed their miscues today, a lot of those should've been nocalls, and some of them should h ave even been called opposite --- offensive PI. It got to a point where I expected a PI call on every Cutler throw. Hell, they marched down the field on their first TD on nuthing but PI calls. It was ridiculous. I believe it robbed the Colts of some early confidence, in the least.
- The first Luck interception was badly called -- should've been encroachment or neutral zone infraction on CHI's defense. That was a huge play, incorrectly called.
- Luck continues to show moxy in the 2-minute drill.
- Speaking of Luck --- almost identical first game to Manning. Showed a lot to me. He is extremely capable of moving the ball, but makes rookie miscues. A few of his passes seemed lazy. These are things I know he'll correct, just like Manning, who's first game was almost identical to Luck's, even made the same mistakes. I loved what I saw out of Luck, mistakes and all. I know he'll be tremendous once everything slows down for him. The "mistakes" I'll credit to Luck were a few careless/ill-advised throws, not putting enough on them when trying to squeeze them into tight places, he'll learn, though. The NFL is faster. I expect his eyes have been opened in that regard, and we'll see more zip on those passes. But still, 300 yards, against this Bears D --- impressive. Hell, he's 1 pass away from having about 340 yards and a 2/2 TD ratio instead of 1/3. Interception in the end zone. And if you discount the lame interception on the play where CHI Defense jumped off-side, he shouldn't have had 3 interceptions...
- Our receivers need to catch the f'n ball. Too many drops. Brown was caught blatantly taking his eyes off the ball a number of times --- can't be doin' that ****.
- I think we'll look better against lesser teams, and I also think we'll improve over the next few weeks. I still think 6 wins is our ceiling. It's easy to get down after a game like todya, but you gotta think... we're very young, a ton of inexperienced guys, so you'll get better week-to-week just by default... and we also will get a few key guys back in the next weeks --- Collie, Hilton, Angerer, etc... That will change things. It won't always look as rough as it looked today... it's not logical to go into Soldier Field against a very good Bears team/defense as a rookie QB throwing to mostly rookie receivers and expect a win.
Luck vs. RG3 --- Wouldn't ya know it. Exactly what I said. 'Skins have a better team, period. Much better o-line, better defense. So of course he looked better and had better stats. If Luck had as much time as RG3 to throw, he woulda had astronomical numbers. Remember Newton had a ridiculous first game and trailed off big-time as the season went on. Don't get sold on RG3 yet, although I do think he'll be a fine QB.... but don't get used to this production. Saints have holes, not as good as Chicago, I saw that coming.
Last edited by Kid Minneapolis; 09-09-2012 at 05:15 PM.
There are two types of quarterbacks in the league: Those whom over time, the league figures out ... and those who figure out the league.


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5 Common Resume Mistakes That Can Sink Your Candidacy
By Skip Freeman,
"Headhunter" Hiring Secrets
While, ultimately, the claim that the traditional
is "dead" may indeed prove to be true, significant to note, currently it still has a LOT of life left in it!
As I've mentioned in previous blogs, some high-tech companies seem to be moving toward the video-oriented resume (or some other "non-conventional" format), yet the vast majority of companies today continue to rely upon the more traditional,
resume. That means, of course, that savvy
hunters need to continue to concentrate on making sure their resume brand them as true professionals and not as rank (and "sloppy") amateurs.
That said, an embarrassing number of professionals continue to repeat the same—yet all really quite avoidable!—mistakes in their resumes, and these mistakes more times than not result in one predictable outcome—the candidates are
eliminated from further consideration! How do I know this? Because, as professional "headhunter," I see resumes containing these mistakes each and every business day of the year, and so, coincidentally, do most other "headhunters" and hiring professionals.
The 5 Most Common Resume Mistakes I See
Certainly, not every "problem" resume that pops up on my office computer screen contains all of the five mistakes mentioned below, but statistically, and with regard to my executive recruiting firm,
Hire to Win
, these are the five most common ones:
1. Confused—and confusing!—design and layout.
The "good" news is the same as the "bad" news here: Most word processing programs today provide users with the capability of easily and quickly creating good (and varied) design and layout for virtually any document, including, of course, a resume. In the hands of someone who understands and appreciates what constitutes good design and layout, the results can be excellent. In the hands of someone who does
have such understanding and appreciation, however . . . well, that can be an entirely different matter.
Imagine picking up, say, a newspaper or magazine, and finding wall-to-wall copy, indiscriminate (and inappropriate) use of
bold face
, a dizzying array of type faces and sizes, etc., a total lack of "white space" or other graphic/design devices/elements typically used to "break up" and "highlight" the copy, etc. Wouldn't be very "inviting" reading, would it? Now, imagine, as a hiring professional, receiving a resume which features such design and layout
faux pas
2. Misspellings, grammatical errors.
Having misspellings in
professional document or publication has never been deemed acceptable, but today, with the "spell check" feature on word processing programs, it is
inexcusable. There is only
conclusion that can logically be drawn today about the professional who has misspellings in his/her resume: He or she was simply too lazy to use "spell check"! (Will he/she be equally lazy if selected for a position under consideration? Probably).
Now, you may get a little slack with grammatical errors. Why? Because the truth of the matter is, the vast majority of Americans today don't have an extensive knowledge and understanding of English grammar. Oh, they know, usually, though certainly not always, if a subject and verb don't agree, but get beyond such grammar basics and most are simply lost (although, certainly not
are lost!). Indeed, most people wouldn't recognize a dangling participle if one were . . . well . . . dangled in front of them! Nonetheless, when in doubt about a question of grammar, you should check it out, and that is easily done on the Internet today!
3. Lack of clarity, focus.
In a perfect world, every professional's resume would quickly and clearly illustrate his or her particular skill set(s), previous and current positions held, specific duties and meaningful accomplishments and achievements (using dollars and cents, percentages and other pertinent
measures). It would also be
-focused toward the new position being sought, i.e., what the candidate has to offer the hiring company, how he or she can "make 'em money," "save 'em money," or both. Obviously, the world we live in today is anything but perfect.
Far too many resumes today practically defy the hiring professional to determine, first, what, specifically and significantly, the professional has done in previous positions, or is doing in his/her current position. And, second, precisely (at least by inference), how his/'her past and current experience and achievements can easily translate into significant and relevant benefits for the hiring company.
Many are the times that I have to scratch my head and wonder precisely what it is the candidate is trying to convey about himself/herself and why my hiring company clients should even care!
4. Incomplete/ incorrect contact information.
I wish I had a dime—no, make that a
!—for every time I have attempted to reach a prospective candidate who "looked good on paper" at the contact phone number or email address indicated on his or her resume, only to be met with a "I'm sorry, the number you have dialed is no longer in service . . ." message, or, I am forced to leave a voice mail message that is never returned. Or, equally bad, to have my emails rejected because the prospective candidate apparently made a typographic or other error in his/her email address.
5. Inappropriate length.
Oh, the perennial question: How many pages long should a resume be? Answer: In most cases, ONE page; in very rare instances, such as very top level management resumes, TWO pages, MAXIMUM! The typical fate of those resumes which do not adhere to this principal?
With Just a Little Bit of Care . . .
To be sure, this blog is not a comprehensive treatment of all of the resume mistakes that I (and other hiring professionals) see each and every business day. Nor is this an exhaustive treatment of those mistakes that you should assiduously avoid, if you desire to be perceived as a true professional instead of a "run-of-the-mill" amateur who is "just looking for a job, any job."
Simply by taking greater care and practicing more focused concentration, you should easily be able to avoid making these mistakes (and other equally harmful ones) when creating
professional resume. Make sure you do!
Read more
biotech career tips
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About the Author
Skip Freeman is the author of "
Headhunter' Hiring Secrets: The Rules of the Hiring Game Have Changed... Forever!
" and is the President and Chief Executive Officer of
The HTW Group (Hire to Win)
, an Atlanta Metropolitan Area Executive Search Firm. Specializing in the placement of sales, engineering, manufacturing and R&D professionals, he has developed powerful techniques that help companies hire the best and help the best get hired.
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text:
Charlton will begin the new Championship season on August 9 with a London derby at newly-promoted Brentford.
The Addicks' first home game the following week is against Wigan which is quickly followed by a midweek Valley encounter with Derby on August 19.
Bob Peeters' side then travel to Brighton (August 23) and Huddersfield (August 30) before the first international break.
September's games are Watford (H 13th), Wolves (H 16th), Rotherham (A 20th), Middlesbrough (H 27th) and Norwich (A 30th).
The derby games with Millwall take place at The Valley on November 22 and at The Den on April 4.
Boxing Day sees a home meeting with Cardiff City while Charlton finish the campaign on May 2 in SE7 against Bournemouth.
August: 9 Brentford (a), 16 Wigan (H), 19 Derby (H), 23 Huddersfield (a), 30 Brighton (h).
September: 13 Watford (h), 16 Wolves (h), 20 Rotherham (a), 27 Middlesbrough (h), 30 Norwich (a).
October: 4 Birmingham (h), 18 Bournemouth (a), 21 Bolton (h), 25 Fulham (a).
November: 1 Sheffield Wednesday (h), 4 Leeds (a), 8 Reading (a), 22 Millwall (h), 29 Ipswich (h).
December: 6 Nottingham Forest (a), 13 Blackpool (h), 20 Blackburn (a), 26 Cardiff (h), 28 Ipswich (a).
January: 10 Brighton (h), 17 Watford (a), 24 Wolves (a), 31 Rotherham (h).
February: 7 Middlesbrough (a), 10 Norwich (h), 14 Brentford (h), 21 Wigan (a), 24 Derby (a), 28 Huddersfield (h).
March: 3 Notts Forest (h), 7 Cardiff (a), 14 Blackburn (h), 17 Blackpool (a), 21 Reading (h).
April: 4 Millwall (a), 6 Fulham (h), 11 Sheffield Wednesday (a), 14 Bolton (a), 18 Leeds, 25 Birmingham City (a).
May: 2 Bournemouth (h).
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Simultaneous Versus Sequential Antiretroviral Therapy (ARV) Therapy and Mycobacterium Tuberculosis (MTB) Treatment
This study has been terminated.
(Other published trials showed definitive expected superiority of Group 1)
Instituto Nacional de Enfermedades Respiratorias
Consorcio de Investigación sobre VIH/SIDA/TB (CISIDAT).
Information provided by (Responsible Party):
Gustavo Reyes-Teran, Instituto Nacional de Enfermedades Respiratorias
ClinicalTrials.gov Identifier:
First received: August 19, 2008
Last updated: March 24, 2015
Last verified: March 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to evaluate and compare the efficacy of immediate antiretroviral therapy versus 2 month deferred anti-Tb therapy upon the clinical course of tuberculosis and HIV infection in patients with AIDS and active tuberculosis.
|HIV AIDS Tuberculosis
|Drug: Simultaneous ARV and antiMTB Drug: Deferred RV and antiMTB treatment
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Efficacy of Simultaneous Versus Sequential Antiretroviral Therapy and Antituberculosis Treatment in Patients With AIDS and Active Tuberculosis. Open, Randomized and Controlled, Multisite Clinical Trial.
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS TuberculosisU.S. FDA Resources
Further study details as provided by Gustavo Reyes-Teran, Instituto Nacional de Enfermedades Respiratorias:
Primary Outcome Measures:
- Time to remission of signs and symptoms of active tuberculosis as well as general symptoms. [ Time Frame: 96 wk ]
- Time to negative measurement of mycobacterial load in body fluids or affected tissues [ Time Frame: 24 wk ]
Secondary Outcome Measures:
- CD4+ cell count increase [ Time Frame: 24 wk ]
- Lymphoproliferative response to specific antigens against Mtb [ Time Frame: 24 wk ]
- Time to undetectable HIV plasma load; HIV genotype [ Time Frame: 24 wk ]
|Study Start Date:
|March 2008
|Study Completion Date:
|February 2011
|Primary Completion Date:
|February 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Group 1
Receives both, simultaneously antiretroviral therapy and antituberculosis therapy
Drug: Simultaneous ARV and antiMTB
Receives both, simultaneously antiretroviral therapy and antituberculosis therapy
Other Names:
Experimental: Group 2
Receives only antituberculosis therapy, and 2 months afterwards antiretroviral therapy
Drug: Deferred RV and antiMTB treatment
Receives only antituberculosis therapy and 2 months afterwards antiretroviral therapy
Other Names:
Detailed Description:
AIDS and tuberculosis are two international and national priority public health problems. The best time for starting antiretroviral therapy in patients with AIDS and active tuberculosis is not clear, despite of the guidelines regarding CD4+ count. The debate surrounding this issue is mainly due to the difficulty among adherence of anti-MTb and anti-HIV treatment, the pharmacological interaction, the adverse events related to drugs and the risk of inflammatory reconstitution syndrome, especially in patients with advanced HIV infection. Moreover, there is great debate upon the lack of knowledge of the degree of immune reconstitution throughout time against Mtb induced by the anti-HIV therapy.
|Ages Eligible for Study:
|18 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV infected
- < 200 CD4+ cells/mL
- Active pulmonary tuberculosis (with or without extrapulmonary involvement)
Exclusion Criteria:
- Meningeal tuberculosis
- Unable to attend 96 wk follow-up
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00737724
Please refer to this study by its ClinicalTrials.gov identifier: NCT00737724
|Centro de Investigaciones en Enfermedades Infecciosas
|Mexico city, DF, Mexico, 14080
|Hospital Civil de Guadalajara Fray Antonio Alcalde
|Guadalajara, Jalisco, Mexico, 45235
Sponsors and Collaborators
Instituto Nacional de Enfermedades Respiratorias
Consorcio de Investigación sobre VIH/SIDA/TB (CISIDAT).
|Principal Investigator:
|Gustavo Reyes-Terán, MD
|Instituto Nacional de Enfermedades Respiratorias
More Information
Additional Information:
Keywords provided by Gustavo Reyes-Teran, Instituto Nacional de Enfermedades Respiratorias:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
Additional Information:
Raviglione MC, Narain JP, Kochi A. HIV-associated tuberculosis in developing countries: clinical features, diagnosis, and treatment. Bull World Health Organ. 1992;70(4):515-26. Review.
De Cock KM, Soro B, Coulibaly IM, Lucas SB. Tuberculosis and HIV infection in sub-Saharan Africa. JAMA. 1992 Sep 23-30;268(12):1581-7. Review.
Whalen C, Horsburgh CR, Hom D, Lahart C, Simberkoff M, Ellner J. Accelerated course of human immunodeficiency virus infection after tuberculosis. Am J Respir Crit Care Med. 1995 Jan;151(1):129-35.
Goletti D, Weissman D, Jackson RW, Graham NM, Vlahov D, Klein RS, Munsiff SS, Ortona L, Cauda R, Fauci AS. Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation. J Immunol. 1996 Aug 1;157(3):1271-8.
Chaisson RE, Clermont HC, Holt EA, Cantave M, Johnson MP, Atkinson J, Davis H, Boulos R, Quinn TC, Halsey NA. Six-month supervised intermittent tuberculosis therapy in Haitian patients with and without HIV infection. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1034-8.
Small PM, Schecter GF, Goodman PC, Sande MA, Chaisson RE, Hopewell PC. Treatment of tuberculosis in patients with advanced human immunodeficiency virus infection. N Engl J Med. 1991 Jan 31;324(5):289-94.
Burman WJ, Jones BE. Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy. Am J Respir Crit Care Med. 2001 Jul 1;164(1):7-12. Review.
Dean GL, Edwards SG, Ives NJ, Matthews G, Fox EF, Navaratne L, Fisher M, Taylor GP, Miller R, Taylor CB, de Ruiter A, Pozniak AL. Treatment of tuberculosis in HIV-infected persons in the era of highly active antiretroviral therapy. AIDS. 2002 Jan 4;16(1):75-83.
Narita M, Ashkin D, Hollender ES, Pitchenik AE. Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. Am J Respir Crit Care Med. 1998 Jul;158(1):157-61.
Lawn SD, Bekker LG, Wood R. How effectively does HAART restore immune responses to Mycobacterium tuberculosis? Implications for tuberculosis control. AIDS. 2005 Jul 22;19(11):1113-24.
de Jong BC, Israelski DM, Corbett EL, Small PM. Clinical management of tuberculosis in the context of HIV infection. Annu Rev Med. 2004;55:283-301. Review.
|Responsible Party:
|Gustavo Reyes-Teran, Principal Investigator, Instituto Nacional de Enfermedades Respiratorias
|ClinicalTrials.gov Identifier:
|NCT00737724 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 19, 2008
|Last Updated:
|March 24, 2015
Keywords provided by Gustavo Reyes-Teran, Instituto Nacional de Enfermedades Respiratorias:
Enzyme-Linked ImmunoSpot
Deferred treatment
Immune Recovery Inflammatory Syndrome
Additional relevant MeSH terms:
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination
Antitubercular Agents
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 Enzyme Inducers
Cytochrome P-450 CYP3A Inducers
Anti-HIV Agents
Anti-Bacterial Agents
Fatty Acid Synthesis Inhibitors
Hypolipidemic Agents
Lipid Regulating Agents
ClinicalTrials.gov processed this record on September 25, 2017


text: TurkAlert.com is a free service enabling Mechanical Turk workers to easily keep track of their favorite requesters and receive e-mail notifications when those requesters make new HITs available. Requesters can also benefit from TurkAlert by promoting their HITs on the site, avoiding the problem of their HITs being lost in the din and churn of the tens of thousands of HITs available on mturk.com. This results in speedier HIT completion, and--as TurkAlert is frequented by dedicated and experienced Turkers--higher quality results with less expenditure.


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You can't go wrong with this all-inclusive turtle habitat kit that lets you easily create a comfortable, professional-caliber turtle environment. Kit has everything you need to happily house turtles without the frustrating guesswork. Lightweight, eco-friendly, easy-clean Turtle Tub, is made from 100% recycled materials and replicates a natural pond environment by providing a water area and a land area. 160 gph Turtle Clean filter has an extra-large carbon media chamber and keeps water fresh and healthy to help eliminate smelly odors and debris. The powerful Powersun UV lamp provides essential heat and UVB light in order to optimize your turtle's health. This hassle-free kit even includes an informational book on how to care for and maintain a successful water turtle habitat.
Turtle Tub Kit Includes: 21" X 39" X 16" Deep Turtle Tub, Large Reptile Lamp Stand, 100W Powersun UV And Heat Lamp, Mini Deep Dome Lamp Fixture, 511 Turtle Clean Canister Filter, 8 Oz Bottle Reptisafe Water Conditioner, 8 Quarts Eco Earth Coconut Fiber Substrate, 8 Quarts Forest Floor Cypress Mulch Substrate, 1 Medium Natural Bush Plant, Proper Care And Maintenance Of Water Turtles Book, 1 Turtle Bone Floating Calcium Supplement, 1 Package Sun-Dried Red Shrimp, And 1 Package All-Natural Aquatic Turtle Food.
Please click on "More Information" for assembly instructions.


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'Toy Story of Terror' Trailer: First Look at Footage From Pixar's First TV Special
The 'Toy Story' gang may have had a memorable cinematic farewell with the wonderful 'Toy Story 3,' but we're not done with Bonnie's (formerly Andy's) toys quite yet! The Woody, Buzz and the rest of the group are going to make their television debut with 'Toy Story of Terror,' a made-for-TV Halloween special that will attempt to bring some of that Pixar magic to the small screen. The first two promos for the special have arrived and ... it looks like more 'Toy Story.' That's a good thing, right?


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Pizza is certainly off to an entertaining start this week. But come on! AS IF Patrick Stewart needed to do virtually anything else to worm his way into my heart and melt the core of my very being into a puddle of reverent, space geeky adoration. How he survived this long without pizza, I will never know; now that he's had it...I guess we are soulmates. Well played, Mr. Stewart. Well played. I hope they cut his pie with this guy:
Star Trek Enterprise Pizza Cutter
Then, of course, there's the viral video of a delivery man in Russia who was caught with his hand in the proverbial cookie jar—or the literal pizza box—thanks to a well-placed elevator camera at the delivery site. The fact that he decides to snack on a customer's pie is actually less remarkable than the practiced speed and grace with which he unzips the bag, opens the box, and plucks his preferred toppings off the pie—all in time to close up shop, stifle a yawn, and then make the delivery. Also, his choice to do all of this in an elevator.
In all seriousness, though, it looks like the guy actually realizes he has the wrong order and decides to eat off the extra topping rather than suffer the consequences.
Snack Time!
Rounding out the headlines is this charming piece on enjoying a good old-fashioned, fresh-from-the-oven cicada pizza. Personally, I'm intrigued. Any takers out there?
Cicada Pizza
About the author: Niki Achitoff-Gray is the associate editor of Serious Eats and a part-time student at the Institute of Culinary Education. She's pretty big into pizza. Also, she likes offal. A lot.


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NEW YORK Macy's is celebrating Hispanic Heritage Month with the launch of its El Encanto Latino campaign.
"An empowering call to action, Macy's El Encanto Latino events will help celebrate Latino culture and contributions while also giving participants the tools to live healthier. As a corporate citizen and one with a large population of Hispanic employees and customers, we are excited to once again bring the magic of Latino culture to life in our stores through celebrations that shine a spotlight on style, culinary and cultural traditions," said Corliss Fong, Macy's VP diversity strategies.
During Hispanic Heritage Month, Macy's will host special in-store events at select stores across the nation including locations in Miami; Denver; Santa Ana, CA; Chicago; San Francisco; Wheaton, MD; San Antonio; Houston; Los Angeles, and New York City. Speakers will include Barbara Trujillo Gomez, Lilly Mucarsel, Evelina Solis and Luz Maria Briseno. Each moderator will create a dialogue with participants around the importance of empowering oneself to succeed via positive thinking, fitness and maintaining a healthy lifestyle, Macy's reported.
Customers who attend the Encanto Latino events will also receive a one-day 15% off pass and a Macy's Encanto Latino apron gift with a purchase of $50 or more (while supplies last).


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St. Louis -- Build-A-Bear Workshop reported a net loss of $4.3 million in its third quarter, compared with net income of $0.9 million a year ago, and said it would close 50 to 60 underperforming locations in the next two years in an effort to improve its profitability and reach its "optimal" count of 225 to 250 locations.
The company also said that sales from stores with its new interactive store design had exceeded its expectations, and this success would allow it to add elements or in some cases fully remodel its most productive stores. The retailer is on track to have six stores open in the new format by the end of fiscal 2012.
For the third quarter, ended Sept.29, Build-A-Bear Workshop said consolidated net retail sales decreased 11.9% to $84.3 million, compared with $95.4 million in 2011, excluding the impact of foreign exchange.
Same-store store sales decreased 11.1%, which included an 11.8% decrease in North America and a 7.9% decrease in Europe.
Maxine Clark, Build-A-Bear Workshop's CEO commented: "Clearly we are disappointed with the quarter's results. We were up against a difficult comparison from last year when product tied to the theatrical release of the Smurfs led to incremental traffic and transaction growth throughout the quarter."


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Available ebook formats: epub mobi pdf rtf lrf pdb txt html
Writer and artist, Ryan M. Williams, author of more than twenty novels, writes across a range of genres including fantasy, science fiction, romance, paranormal, and mystery. He holds a master degree from Seton Hill University in writing popular fiction. His short fiction has appeared in anthologies from Pocket Books, WMG Publishing, and in On Spec Magazine.


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Gregorius feeling better; CT scan results normal
PHOENIX -- A day after being drilled in the helmet with a 93-mph fastball, D-backs shortstop Didi Gregorius reported feeling sore, but better, on Saturday. The rookie underwent a precautionary CT scan late Friday and the results came back normal.
D-backs manager Kirk Gibson said the club won't place Gregorius on the seven-day concussion disabled list for now, but he wouldn't rule it out entirely.
"We'll see how he's doing as the day progresses," Gibson said. "There is just a protocol you follow in these situations and we will certainly err on the side of caution."
In the meantime, the D-backs will play a man down with Gregorius in limbo. Gibson expects the club to make a decision on the shortstop either Sunday or Monday.
Since making his team debut on April 18, Gregorius, the D-backs' No. 3 prospect according to MLB.com, was batting 11-for-27 (.407) with six extra-base hits, including a pair of homers. Friday was the first time in his baseball career that he had been hit in the head with a pitch.
"I tried to get out of the way, but I wasn't fast enough," he said. "It swelled up yesterday, and I had a light headache. It feels sore, but otherwise I feel good."
After being struck, Gregorius immediately fell to the ground and was tended to by a member of the D-backs' training staff. He remained on the ground for a couple of minutes, but he said he never lost consciousness.
"I couldn't get up right away and they told me to stay down too," he said. "Then I was talking for a little bit. At least I didn't get knocked out."
Despite the inherent scariness of the injury, Gregorius said he harbors no ill feelings toward Rockies reliever Josh Outman, who hit him with the pitch.
"I don't think he did it on purpose so everything is good," Gregorius said. "I had two strikes on me anyways."
Even though the two hadn't talked yet on Saturday, Outman expressed a desire to apologize to Gregorius sometime this weekend before the Rockies leave town.
Tyler Emerick is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Gentry begins throwing, but can't swing bat yet
OAKLAND -- A's outfielder Craig Gentry, on the disabled list since July 28 with a broken right hand, threw Thursday and was scheduled to throw again Friday, but he is not yet able to swing a bat. Gentry said Friday that his hand is still pretty sore.
"I'm still waiting for the bone to heal, so I haven't really been doing too much," he said. "I'm kind of working on a little bit of grip strength right now and making sure my legs are strong."
Gentry was hit on the hand attempting a bunt in Houston on July 27. Initial X-rays showed no damage, but an MRI the next day revealed a non-displaced fracture.
He was batting .264 with 18 steals in 19 attempts when he went on the DL.
With Gentry down and Coco Crisp dealing with an ongoing neck issue, Sam Fuld has started seven of his first eight games for Oakland since being traded from the Twins. Fuld was in center field on Friday against his former team. with Crisp at DH.
Aaron Leibowitz is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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TORONTO — Last year, the Toronto Heschel School replaced its annual fundraising gala with a lower-key idea that organizers say not only brought in more money than its predecessor, but created a buzz and enhanced the school's sense of community.
Now in its second year, Table Talk consisted of 11 separate dinner parties in private homes, each with a guest speaker and a catered, kosher, gourmet, four-course dinner. Hosts donated the cost of the meals, and funds raised this year at the $150-a-plate event will be used for new science equipment for the school, which was founded in 1996 and runs from junior kindergarten to Grade 8.
"We wanted to reinvent the gala and think of something that would celebrate the community, be intimate, and would address the intellectual curiosity the parents share – and that would be fun," event co-chair Michelle Shulman said.
"The speaker stays for dinner, and conversation is great."
She said she has heard of similar fundraisers in the United States, but not locally.
Lainie Rapp, the mother of a senior kindergarten student, attended the March 25 dinner at the home of Lisa Richler and Yishai Wise, where author David Sax spoke about his book, Save the Deli: In Search of Perfect Pastrami, Crusty Rye, and the Heart of Jewish Delicatessen.
Rapp, a palliative care social worker whose husband, Gary Cilevitz, is an accountant, said the light-hearted topic was their number 1 choice, and that they looked forward to spending time with the hosts, whom they know from the school.
The menu, aside from the appetizers, did not feature deli food – much to Cilevitz's dismay, his wife noted. However, she said, the balsamic vinaigrette chicken that was served as a main course was "fantastic."
Some of the other dinners featured weightier presentations: Muslim author Tarek Fatah on his book The Jew is Not My Enemy, neuropsychiatrist Anthony Feinstein on "Journalists Under Fire," Rabbi Joe Kanofsky on Rabbi Abraham Joshua Heschel and Martin Luther King, Jr., and author Marina Nemat on her journey to Canada from Iran, where, as a teenager, she was imprisoned on false charges.
But Rapp said the talk about deli food, which included information about Jewish immigration from different countries and how those patterns influenced local deli trends, was "very stimulating."
As well, she enjoyed meeting people she wouldn't otherwise know. There were 13 at her table including parents of older children and one couple who have grandchildren at the school, she said.
Compared to large galas, "this is a much more intimate setting, and it really falls in sync with the whole Heschel philosophy of community building."
But the best thing, Rapp said, was the "buzz" at the school the next morning. "If you're talking about building community, this was the epitome. We were all running up and down the halls [asking] 'Where did you go?' 'How long did you stay?' "
The event "really reflects who we are as a community," Shulman said. "We're not a neighbourhood school. We're together because we share common values."
This article appears in the April 5 print issue of The CJN


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Yost runs across off-limits area at Chiefs' practice
KANSAS CITY -- As if things weren't going bad enough for Royals manager Ned Yost, he almost got busted Tuesday for gawking at the Kansas City Chiefs' practice.
Yost went for a run on the back roads of the Truman Sports Complex that the Royals share with the Chiefs and happened upon the NFL team's offseason practice session.
"I ran today and almost got arrested for a taking a peek at the Chiefs doing their minicamp. They surrounded me with their security," Yost said good-naturedly. "I'm not going to sell any secrets."
Well, NFL teams are notoriously guarded about their practice activities, and this area, unknown to Yost, happened to be off-limits.
"Hey, I just wanted to see what was going on," Yost told the security guards. "They said, 'Well, you can't be here, it's closed.'"
Yost identified himself, and the crisis passed.
"The guy said, 'Oh, hi Ned, how's it going?'"
Not too well, actually. His team lost 17 of its past 21 games, and now he almost got pinched for invading a football practice. That's when you know you're in a slump.
Dick Kaegel is a reporter for MLB.com. Kathleen Gier is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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For Civil War geeks, this week is like the Super Bowl.
I know, because I'm a card-carrying member of that clan.
Today is the 150th anniversary of the first day of the most pivotal battle of the American Civil War, Gettysburg. Nearly 100,000 people are expected to converge on that still-sleepy Pennsylvania town for re-enactments of the battle. I'll be one of them. It's been on my bucket list for a long time, being there for this.
I'm a peacable guy. I've never fired a gun. So why am I so endlessly moved and fascinated by this gruesome, grinding, long-ago conflict?
Literally my first memory is of seeing the old Gettysburg battle map when I was 3. The next year, a family visit to Atlanta, and the cyclorama painting of the Battle of Atlanta, cemented the obsession. My kids still shake their heads – fondly, I hope – at memories of summer trips to the Carolina shore being diverted for quick side trips to battlefields.
I'd wander about happily, echoes of distant trumpets in my head, while my wife would mutter, "It just looks like a big grass field to me."
No battle of the war is more rife with drama and poetry than Gettysburg.
For NewsWorks' package on the battle anniversary, I wrote an essay that tried to pin down why I find the Civil War such a moving, resonant thing.
Here's how it went, in part:
This was no push-button war of drones and precision bombs. It was intimate, hand-to-hand, ugly in the moment and horrific in the aftermath. The wounded moaned in the crumpled fields, and the surgeon's saws grew dull from use.
It was chaos unleashed upon an ordinary Pennsylvania landscape – gentle ridges, a peach orchard, a wheat field, a warren of boulders known as Devil's Den.
In the three days of Gettysburg, more Americans died than in the long anguish of the Iraq War. In three days, 52,000 either died, were wounded, taken prisoner or melted into the mist.
Michigan farm boys, Massachusetts clerks, cocky Irish from Brooklyn.
In dying, so horribly and in such droves, they saved the union, and bequeathed us our nation. That is why this battle anniversary matters. As the bearded man in the tall hat once said, this is why we must never forget.
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Losing those pregnancy pounds might be at the front of your mind. But there's something that's even more important for your body after your baby arrives: eating foods that give you the energy to be the best mom you can be.
Routinely eating healthy foods throughout the day will maximize the little energy you probably have as a new mom. If you're nursing, the quality of your breast milk stays pretty much the same no matter what you choose to eat. But there's a catch: When you aren't getting the needed nutrients from your diet, your body will provide them from your own stores. So make sure you get all the nutrients you and your baby need. It will benefit both of you.
Try to make these healthy foods a regular part of your diet.
There's no such thing as a perfect food. But salmon is pretty close to it when it comes to a nutritional powerhouse for new moms. Salmon, like other fatty fish, is loaded with a type of fat called DHA. DHA is crucial to the development of your baby's nervous system. All breast milk contains DHA, but levels of it are higher in the milk of women who get more DHA from their diets.
The DHA in salmon may also help your mood. Studies suggest it may play a role in preventing postpartum depression.
One caution: The FDA recommends that breastfeeding women, women who are pregnant, and women who might get pregnant limit how much salmon they eat. The guidelines recommend an average of 12 ounces, or the equivalent of two main servings, per week. The reason is to limit the amount mercury your new child is exposed to.
The mercury level in salmon is considered low. Some other fish, such as swordfish or mackerel, have a high amount of mercury and should be avoided altogether. The 12 ounces are an average. Eating more in 1 week -- such as having three servings instead of two -- won't hurt as long as you eat less the following week.


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VILLAGERS will soon be toasting the re-opening of their beloved pub after an entrepreneurial husband and wife team stepped forward to run it.
Greg and Caroline Saturley and their family have moved into the former Bell and Castle pub in Horsley with plans to re-launch the local as The Hog before the end of May.
The outcome is the ideal result for villagers, who had pledged £250,000 to keep the premises open as a pub after the building's owners put it on the market.
A committee of Horsley residents first discussed the possibility of the pair running the pub after visiting their thriving Canteen restaurant in Nailsworth.
Father-of-two Greg said: "It is really the most remarkable journey from The Canteen to The Hog as the villagers visited my place in Nailsworth out of the blue.
"They paid us the ultimate compliment when they asked to see the cooking facilities and said they wanted to show how wonderful things can come out of a small kitchen.
"They liked our ethos of sourcing local food and after discussions about us running the pub we decided it would be a great opportunity."
The pub has been at the centre of four different planning applications since it closed its doors in 2008, the last of which considered building three houses on the site.
Villagers had previously attempted to buy the building themselves but their bid was rejected by owners Stag Developments Ltd as it fell short of the £400,000 asking price.
Mark Carden, who chaired the residents' committee, said everyone was delighted with the outcome, despite their own attempt to purchase the pub failing to materialise.
"This is a great result, given that our negotiations with Stag Developments had stalled for the moment," said Mark, a recruitment consultant who has lived in the village for nearly 20 years.
"Of course, many of us will feel some regret, after all the work that has been done, that we will not be buying the pub for ourselves.
"But it will also be a relief for many that we will not have to invest our own money, and more of our time, to ensure that the pub opens."
Greg and Caroline will initially run the pub as a leasehold but hope to purchase the business outright later in the year.
Caroline added: "The aim is to make The Hog an exciting and contemporary eatery as well as a popular pub.
"The ethos will be to give people what they want and having the support of the local community is essential."


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Video: iHome iW1 AirPlay wireless speaker
Most of the people appearing in our videos are employees at Crutchfield. We pull in folks from around the company to share their expertise. A lot of our on-camera stars come from our Advisor Group — they help people choose the right gear via phone, email and chat every day, so they're good at explaining the products and technologies.
Heads up!Welcome to this article from the Crutchfield archives. Have fun reading it, but be aware that the information may be outdated and links may be broken.
Michael Lee from iHome came to Crutchfield for a training, and showed us the portable iHome iW1 AirPlay® wireless speaker.
Video Transcript
Michael: I'm Michael at iHome here today at Crutchfield headquarters talking with their audio/visual experts about iHome's new iW1 featuring AirPlay.
AirPlay is Apple's newly released wireless streaming technology that allows you to enjoy your tunes wirelessly over your Wi-Fi network streaming from your computer, your iPod Touch, iPhone, and iPad.
Setting up your iW1 is very simple. Two ways to do it: one is through your home computer and your Wi-Fi network, the second is through the iHome connect app via the USB synch cable. Launch the app, choose your network, and you're off and running ready to start streaming your music wirelessly all over your house through your Wi-Fi network.
The iW1 is truly your wireless solution in that it's got a fully rechargeable lithium ion battery that gives you hours of play time to enjoy your music wherever you want to take the iW1.
With this capacitive touch top, controlling the unit is super simple. Also included is a remote where you can adjust the bass, treble, and EQ. With twenty watts of power and Bongiovi DPS with four active speaker drivers your music's gonna sound great. With the iW1, you can position them all around the house to stream up to three from one computer or from your IOS device such as your iPad, iPhone and iPod Touch-one button push and you're up and ready to stream your tunes.