text:
Adidas Football is online with a new advergame created by Preloaded. It's called "Garage Goals" but don't ask me how it is, it takes too many clicks and a registration to play it. Why does Adidas make things so difficult?
adidas advergame advergames advertainment advertising ambient marketing australia belgium best brazil coca-cola email marketing facebook fashion france germany google heineken ikea infographic italy japan marketing mobile content mobile marketing msn nike nokia online ads online advertising online campaign online marketing print advertising rich media samsung sms spain sweden tvc twitter uk video of the day viral marketing volkswagen wieden + kennedy


text:
DHEA Treatment for Sjogren's Syndrome
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study will evaluate the effectiveness of the male hormone dehydroepiandrosterone (DHEA) in treating Sjogren's syndrome. This autoimmune disorder, in which the immune system attacks the salivary glands and tear glands, affects primarily women. Patients' eyes and mouth become drier over time, and can lead to problems such as serious tooth decay and eye irritations. Sex hormones seem to influence the immune response and may help decrease disease severity. DHEA has benefited some patients with two other autoimmune diseases, rheumatoid arthritis and systemic lupus erythematosus.
Women 18 to 75 years of age with Sjogren's syndrome may be eligible for this 7-month study. At the initial visit, candidates will have a physical examination, routine blood and urine tests and eye and dental examinations, including a test to measure saliva production for screening purposes and to establish baseline values for participants.
Those enrolled in the study will be randomly assigned to take either DHEA or placebo (look-alike tablet with no active ingredient) once a day for 6 months and will be monitored with follow-up visits at months 1, 3, 6 and 7. Physical examination, blood tests and urinalysis will be repeated at months 1, 3, 6 and 7; saliva will be collected at months 3, 6 and 7; and eyes will be examined at 3 and 6 months. Because hormone changes may have both physical and emotional effects, patients will be asked questions about their mood, symptoms and side effects of treatment.
It is not known if Sjogren's syndrome is associated with osteoporosis (bone thinning), but since this condition occurs in other autoimmune disorders, patient's bone density will be measured at the first visit, and blood drawn at 3 and 6 months will be tested for various substances associated with changes in bone density. A 24-hour urine collection at the first visit and later urine tests will also be tested for substances associated with bone thinning.
|Lacrimal Apparatus Disease Salivary Gland Disease Sjogren's Syndrome Xerostomia
|Drug: Dehydroepiandrosterone
|Phase 2
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|Dehydroepiandrosterone (DHEA) Treatment for Sjogren's Syndrome
|Estimated Enrollment:
|Study Start Date:
|May 1997
|Estimated Study Completion Date:
|June 2002
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Females with a diagnosis of Primary Sjogren's Syndrome.
No history of breast cancer.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001598
|United States, Maryland
|National Institute of Dental And Craniofacial Research (NIDCR)
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00001598 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 3, 1999
|Last Updated:
|March 3, 2008
Keywords provided by National Institutes of Health Clinical Center (CC):
Salivary Glands
Androgen Therapy
Lacrimal Function
Sjogren's Syndrome
Additional relevant MeSH terms:
Sjogren's Syndrome
Dry Eye Syndromes
Salivary Gland Diseases
Lacrimal Apparatus Diseases
Pathologic Processes
Arthritis, Rheumatoid
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Mouth Diseases
Stomatognathic Diseases
Eye Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Adjuvants, Immunologic
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017

subset: commoncrawl


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By Aleco
In episode two of "What's the Move?" Aleco discusses an open-ended situation which doesn't have a clear answer.
In episode two of "What's the Move?" Aleco discusses an open-ended situation which doesn't have a clear answer.
We kicked off this new series by analyzing a tricky situation which had only one optimal line of play. In episode two we'll take a look at a very different kind of situation, one where there might not be a perfect move at all.
Please let us know in the comments what you would have done in this situation! One of the primary goals of this series is to foster improvement at Hearthstone by generating discussions. We would also love to hear your feedback on the video itself, as the series is still very new and has plenty room to improve on its format.
- Aleco
By Stan
In the latest Hearthstone update, Blizzard made adjustments to several cards. The patch is now live now on desktop and it should become available on mobile devices in the coming hours.
Philosophy and reasons behind these changes can be found here.
Blizzard (Source)
Card Changes
Innervate now reads: Gain 1 Mana Crystal this turn only. (Down from 2)
Fiery War Axe now costs 3 mana. (Up from 2)
Hex now costs 4 mana. (Up from 3)
Murloc Warleader now reads: Your other Murlocs have +2 Attack. (Down from +2 Attack, +1 Health)
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By Pain
Hello guys i would like to share my weakauras for each healing class, hope you like it ;)
Any feedback is appreciated
New to Weakauras ?
You can download it here :
Copy - paste the code of which you can find down below (Import string) On the wago.io webpage links you can find a copy string button on the right, colored red.
Like this : When ingame type /wa to open the control panel of weakaura. Select "import" Paste the string from the wago webpage into this. A screen will pop-up and select the import button on it. ____________________________________________________________________________________________________
Update Log :
17-06-17 : Alot of changes to the Shaman Healing tool and a few to the Druid Healing tool.
26-06-17 : Massive update for Holy palading Healing tool !
01-07-17 : Massive update for Holy Priest Healing tool !
16-07-17 : Big improvement for the Druid Healing tool.
29-07-17 : Shaman healing tool now supports legendary's and trinkets from 7.2.5
25-08-17 : Massive update for Disc Priest healing tool
26-08-17 : Tuned Paladin and Druid healing tool and some small improvements
02-09-17 : Small update for Holy Priest healing tool
15-09-17 : Shaman healing tool now supports PvP feature's and some tuning to Paladin healing tool
Shaman Druid Paladin Priest Monk ____________________________________________________________________________________________________
Starting off with the shaman ↓
Resto Shaman - Healing Tool
Import string : https://wago.io/SJAG4cTub ←
What's making sound :
Riptide - off cooldown
Healing rain - off cooldown
Resto Shaman - Small Healing Tool
If you prefer a smaller setup, you might like this one. (But doesnt cover everything)
Import string : https://wago.io/H1SpVcaOZ ←
Resto Shaman - Cooldowns
Import string : https://wago.io/r1JWBcp_Z ←
Resto Shaman - Usable cooldowns
Import string : https://wago.io/S1u7HqpdZ ←
Druid - Healing Tool
Import string : https://wago.io/H1ZvS9p_b ←
What's making sound :
Life-Bloom - when its about to expire from target
Druid - Cooldowns
Import string : https://wago.io/rJnjBqaOZ ←
Paladin - Healing tool
Import string : https://wago.io/BkQJU96dZ ←
What's making sound :
Holyshock - off cooldown
Paladin - Cooldowns
Import string : https://wago.io/rJibIqTdZ ←
Paladin - Light of Dawn info *additional*
Import string : https://wago.io/HyrN6y4YZ ←
Holy Priest - Healing Tool
Import string : https://wago.io/H1PU8qa_Z ←
Holy Priest - Cooldowns
Import string : https://wago.io/HJvY89au- ←
Holy Priest - Trail of light Talent Tracker *Additional*
Import string : https://wago.io/EyclhaZuZ ←
Disc Priest - Healing Tool
Import string : https://wago.io/SyCn89TdZ ←
Since i know little about monk healing, i do not feel like ill be the right person to try and make a weakaura
for the monk, but i've got a link from someone else his. Since i still want to be some what helpfull to
any healing class.
https://wago.io/4yaTFmN6G ←
*credits to Emarline*
By Vlad
This thread is for comments about our Halls of Valor Mythic+ dungeon guide.
By Zadina
A new Brawl has landed in the Tavern.
Just like with the previous expansions, it's time to try out the deck recipes of Knights of the Frozen Throne in this week's Tavern Brawl. The archetypes for each deck recipe are the following:
Druid: I guess the best name for this deck is Midrange Druid. It has Ultimate Infestation and Spreading Plague, so... PROFIT?! Deathrattle Hunter Elemental Mage Divine Shield Paladin Control Priest (you've probably seen variations of it in ladder) Jade Deathrattle Rogue Freeze Shaman Zoolock Control Warrior with Enrage minions This is a good opportunity to try out cards that you don't own. Good luck and have fun!


text:
Holt's hustle, Cespedes' clutch single end skid
Buchholz's gem spoiled as Uehara allows inherited runners to score
TORONTO -- Brock Holt singled, swiped second, third and then scored the winning run in extra innings as the Red Sox snapped an eight-game losing streak with a 4-3 win over the Blue Jays at Rogers Centre on Monday night.
Holt's heroics came in the 10th after Boston squandered a three-run lead in the bottom of the ninth. With Holt 90 feet away, Yoenis Cespedes had the winning hit, taking an Aaron Sanchez offering to center field.
"It's been a while since we've been able to do it, but the way we responded in the ninth inning, coming back and putting up a run," manager John Farrell said. "Our recent stretch hasn't been for a lack of competitiveness or fight, but we haven't executed to the best of our abilities at times. Tonight we did."
Boston escaped what would've been an ugly collapse after blowing a three-run lead in the bottom of the ninth. Farrell said Cespedes' ability in big situations is what makes him such a valuable addition to the Red Sox since he came over from the A's in the Jon Lester trade.
"He's had some RBIs in key moments, late-inning situations, and once again, today with a game-winning hit," Farrell said. "With a base hit or the long ball, he's been big for us."
The Sox were in complete command until the Blue Jays' final at-bat, but Boston fell victim to a late surge that nearly cost it the game.
Starter Clay Buchholz, who'd been so good for eight innings, allowed back-to-back singles before walking Jose Bautista to load the bases with one out, giving way to closer Koji Uehara.
The right-handed reliever got Adam Lind to hit into a fielder's choice that scored Jose Reyes for the second out, but Uehara couldn't retire Edwin Encarnacion, who followed up with a two-run double to left field that tied the game at 3, sending it to extra innings.
Uehara has struggled in his past two save opportunities. On Friday night against the Mariners, the righty couldn't protect a three-run lead, as he allowed five runs on five hits and recorded just one out. Is fatigue setting in for the All-Star?
"I'm sure it's part of it, to say to what extent, that's probably debatable, but there's no denying the number of appearances he had over a very extended year last year and the number of appearances this year," said Farrell. "We try to give him ample rest in between outings, but he's been in a little bit of a tough stretch."
Despite Uehara's struggles, there are no plans to shut him down.
"We're being very conscious of the frequency of use," said Farrell. "Nothing physical that's of a restriction for him. We check in with him every day, he goes through his normal throwing program. Wouldn't rule it out, but at this point we haven't considered it."
Buchholz said the ninth inning was an exercise in frustration, but he was still pleased with the game's end result.
"The most important part is winning ballgames, regardless of individual stats or whatever," said Buchholz, who went 8 1/3 innings and allowed four hits and three earned runs. "You definitely don't want to go out there and give it up in the ninth, but the team was able to fight back."
After Holt scored to give Boston the lead, lefty Craig Breslow came in and steered the ship to port, retiring three of four batters he faced to earn his first save since Oct. 3, 2010, while he was with the A's.
Holt said his big 10th inning came down to having confidence in his own abilities on the basepaths.
"You've got to trust your speed, and if you think you can take it, take, it," he said. "To get on base in the 10th, you need to score a run and get out of there. Get your defense back on the field and try to win a game."
All that drama came after Mookie Betts and Dustin Pedroia each went yard in the fifth inning to give the Red Sox 3-0 cushion as Buchholz rode what was looking like his best performance of the season into the bottom of the ninth.
The right-hander, who hasn't won since July 18, a span of seven starts, tossed a gem for eight innings, and managed to keep the Blue Jays' bats at bay until the ninth.
Betts got the visitors on the board in the fifth, taking a full-count offering from starter J.A. Happ to the second deck in left field with a solo shot for a 1-0 Boston lead.
Happ walked Christian Vasquez, and two batters later, he allowed a first-pitch two-run shot to Pedroia as the Red Sox took a 3-0 lead.
Jamie Ross is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text: Smell the Coffee: Along came a spider By Karin Fuller May 4, 2013 Story Share CHARLESTON, W.Va. -- So I'm sitting at my desk in my little home office with the window open and a nice breeze blowing. All the furry creatures in the house are present and accounted for. Cats to the right of me. Dog at my feet. Teen texting on the futon.And a spider half as big as a plate at my elbow.He's furry. I'm not kidding -- this dude has more chest hair than Tom Selleck.He's wearing a gold chain. Has a tattoo.If this big boy could speak, he'd sound like Boris Karloff. But he doesn't talk. Is content just to wave. I suppose the waving could be considered friendly, especially since he's waving two legs at once, but it doesn't feel welcoming. It's more like he's practice boxing, throwing jabs at the air. There's a defiance to his moves. Like he's giving the spider equivalent of a thumb-to-nose, "Nyah-nyah."He senses my fear. Makes these cocky little moves toward me. One, two, three -- stop. One, two, three -- stop. More fist pumping.I'm being called out by a bug.I grab a nearby glass, planning to slap it over top of him, except he quickly spreads himself wide and lifts those two arms even higher. Rears back. And then he makes the most effective spider move there is -- he jumps. It's just a little jump, but it's a jump nonetheless, and there's enough athleticism in the move to suggest he's capable of both distance and aim. That he might even be equipped to launch. I put down the glass and raise my hands, palms-forward, hoping it's a cross-species sign of surrender. But the spider does not flee. Instead, he settles himself back a few steps, spreads out flat against my desk. Watches. Occasionally waves.It feels like he's taunting me.Without fully looking away from my new officemate, I begin searching the Internet, hoping to identify his species. The irony of looking on the Web for a spider is not lost on me. I want to identify this heavily muscled arachnid to determine if his bite will be lethal. Considering his size, if he does bite me, perhaps I could ride him to the emergency room.The closest thing I can find online that matches my new companion is called a wolf spider. According to Wikipedia, wolf spiders are robust and agile hunters with excellent eyesight that live mostly solitary lives and hunt alone. "Some are opportunistic hunters, pouncing upon prey as they find it or even chasing it over short distances. Some will wait for passing prey in or near the mouth of a burrow."Great. I've become the goal of an optimistic spider. Figure he's thinking if he can score this one, he won't have to hunt again for the rest of his life.I become engaged with reading the article about wolf spiders. Am briefly distracted, looking away for mere moments to read. When I turn back, he's gone. This is how I came to realize that there's something even worse than having a big, hairy spider sitting beside you, and that's when it's no longer beside you. I briefly consider setting fire to the room, but reason prevails and, after a thorough search with a flashlight and shoe, I settle back into my chair, determined to finish my assignment.Enough time passes that I begin to relax, aided by a rapidly consumed legal beverage. Perhaps sensing my vulnerability, the spider returns -- rappelling like a SWAT team member from somewhere above and landing with a discernible thud when bug butt meets desktop.I scramble backward so fast my chair wobbles drunkenly side to side before crashing to the floor. When I gather myself, I find the spider in position again. Arms raised. Legs spread. Body flattened. But not flattened in the way I now want it to be.I have a general policy against killing spiders. I'm a catch-and-release sort of girl. And as I stared at my foe, I realized that even this guy, as threatening and aggressive though he was, had more of a face than most spiders. It wasn't hatred I saw reflected in those many eyes, but ambition.I couldn't squash ambition. I just couldn't. Especially since I'd just scrubbed down my desk a few days earlier and a body that substantial would make a good mess. Instead, I grabbed my glass and downed the last few gulps of my drink, then flipped it mouth-side-down and, in a move far more adept than I'm generally capable of performing, trapped that monster spider beneath. He remained calm. Seemed unaffected. Tentatively reached forward and touched a drop of the cranberry concoction dripping down the side of the glass.I slide a piece of cardboard underneath and flip him inside, open the window, and set the glass on the ledge, tipping it onto its side so he can simply walk out. Then I quickly close my window. The spider simply sits in the glass, content to touch drops. Makes no attempt to leave. Perhaps the substance that had, moments before, filled the glass are affecting his decision to remain, much in the same way those contents helped fuel my courage in taking him on.But he is outside now, while I am in, with a double pane of glass in between us. For good measure, I lock the window, then sit back on my tuffet. And finish my curds and whey.Reach Karin Fuller via email at firstname.lastname@example.com. Story Share Story Share Trending Now 1 Facebook founder visits Charleston restaurant 2 WVU seeking improvements during off week 3 Gazette editorial: Capito has second chance to do the right thing 4 Innerviews: Dual-identity surgeon riding high in horse racing world 5 Yeager Airport, Air Guard to celebrate 70th anniversary with air show How To: Color outdoors with container plantings Previous Story Garden Guru: Keep a steady pace in the garden Next Story


text:
Wiltshire Police are appealing for witnesses following a serious assault in Trowbridge.
The incident took place at about 4am on Sunday near Conigre Square, Trowbridge.
A 23-year-old male remains in hospital with serious injuries following the attack.
Chris Chammings, Sector Inspector for Trowbridge and Bradford on Avon, said: "Although this is an isolated incident, we are treating it extremely seriously.
"A male was violently attacked and left requiring hospital treatment.
"I am specifically appealing to the local Polish community to come forward with any information they may have to help us with our investigation.
"I'd also like to hear from anyone who was in or near Trowbridge town centre in the early hours of Sunday morning who saw either any arguments between groups of people or anyone with blood on their clothing who was near to the Sainsbury's on British Row.
"I want to reassure the public that incidents such as this are rare and we are working extremely hard to bring the person/s responsible to justice."
Anyone with information is asked to contact Wiltshire Police on 101 or Crimestoppers on 0800 555 111, where information can be left anonymously.


text:
The inscription on a small paper bag summed up the day exactly 20 years ago when the 1994 Northridge Earthquake shook the San Fernando Valley to its knees.
"We lost it all, paused and then rebuilt. Thank you for teaching resilience."
In the dark hour just before sunrise, a small band of Angelenos gathered at Northridge Park to recall that fateful day, Jan. 17, when the earth gave way deep beneath the city to send a 4:31 a.m. shockwave across the region.
When millions of sleepers awoke to a thunderous roar before the jolt that flung them from their beds. When TVs flew, mirrors toppled and homes, businesses and freeways cracked in two.
The 1994 Northridge Earthquake would do far more than kill 57 residents, injure 9,000 and inflict a record $49 billion in property and economic damage, tying up businesses and traffic for months and precipitating rebuilding efforts that would last years.
More than any other earthquake, it jostled a city living atop a labyrinth of faults to better prepare for the expected Big One. To buttress hospitals, homes and freeways. To improve emergency communications and water service. To encourage families to plan an earthquake defense.
Dear God, prayed Los Angeles police Chaplain Ken Crawford, standing in a circle of hands with more than two dozen residents on Friday, "though the Earth may quake and mountains will be carried into the sea, Lord, you will guide us."
"Twenty years ago, this was a devastating event," said Councilman Mitch Englander, whose district includes Northridge, and who was host of the dawn "Afterstories" tribute. "But this was a community that was resilient, that helped each other. Out of the rubble came heroes.
"This was a community that rebuilt. But we shall never forget. Our lives were forever changed."
One by one, the residents from across the Valley recalled the warmer-than-usual Martin Luther King Jr. holiday when their homes and streets suddenly collapsed into rubble.
How the house shook so hard and so long that Pat Pope of Porter Ranch thought it would never stop.
How Valley Planning Commissioner Filiberto Gonzalez, then a freshman at Cal State, Northridge, thought a creature had shaken L.A. by its ears, then flung it into a pile of cracked wood and screaming car alarms. "It felt like a monster had picked up our building and was going to eat us alive," he said.
Los Angeles police Detective Sgt. Bill Bustos recalled the jokester of Valley Traffic Division, Officer Clarence Wayne Dean, who'd rushed down from the high desert on his day off to help victims of the quake.
He died when his police motorcycle, lights blinking, plunged 47 feet off a collapsed section of the Antelope Valley Freeway.
"He was Dizzy," Bustos said, clutching a framed picture of his friend, taken off the wall in the Panorama City station. "He will always be remembered."
Donna Zero recalled hearing a roar, like a train coming through the house. Then she was lifted up atop her water bed, hugging her husband in midair, so as not to spill out together onto the floor.
The earthquake flung open the front door of her Granada Hills home, despite two bolt locks, as well as a bolted front gate. Power wouldn't be restored for four days, water service for a week. Her green-tagged home suffered $200,000 in damage, forcing the family to live in a motel for 20 months. It took seven years to reach a settlement with her insurance company.
"It was the worst nightmare," recalled Zero. "One of the worst parts of the earthquake was getting back to a normal life."
Spread across Northridge Park early Friday were 57 luminarias, lit from within, where people had penned their thoughts about the earthquake.
"I've been afraid of mirrored doors ever since," recalled one. "Happy thoughts on this sad day," recalled another. And "In remembrance of all the volunteers who help tirelessly in assisting the recovery."
Later in the day Friday at Cal State Northridge, whose campus was rebuilt after nearly every building was destroyed or damaged, political and business leaders commemorated the devastating temblor and a city rebuilt in record time. Hosted by the Valley Economic Alliance — a business coalition formed in the aftermath of the earthquake — the "Valley of the Stars: Reaching New Heights" tribute honored seven officials who spearheaded the recovery and seven businesses who had weathered it.
The so-called Magnificent 7 included former Councilman Hal Bernson, former Mayor Richard Riordan, former Gov. Pete Wilson, retired L.A. Public Safety Field Deputy Jim Dellinger and his wife Catherine of Providence Saint Joseph Medical Center, former Los Angeles Fire Chief Frank Borden and Richard Andrews, former director of the governor's Office of Emergency Services.
The seven local businesses and institutions honored for rebuilding out of ruin were 3M Northridge, General Growth Properties, CSUN, Aerojet Rocketdyne, Southern California Gas Co., Galpin Motors and the Los Angeles Daily News.
Riordan said he was jostled awake by the quake, dashed out of his house without combing his hair, then went pedal-to-the-metal down the Santa Monica Freeway until spotting some oncoming headlights. Swerving, he pulled to a stop — just avoiding plunging off a collapsed I-10.
He and Wilson were both credited with cutting through red tape to relight the city, ink rebuilding contracts and get freeways moving in months instead of years. "We just said, 'Let's make it happen,'" Riordan said. "And we did."


text: Well, with the 1K you are saving in rent each month, surely you can lease a nice 7 series to comfortably transport you from your home to your office. The apartment I provided a link to has a garage as well. I didn't see the garage. That might work. I've been operating under the assumption that nobody drives in NYC, but it would be pretty nice to have a car and be able to drive to work.


text:
Live Aqua Urban Resort México, Mexico City
- Free WiFi
Main amenities
- 135 guestrooms
- Restaurant and bar/lounge
- Full-service spa
- Breakfast available
- 24-hour fitness center
- Valet parking
- 7 meeting rooms
- Airport shuttle
- 24-hour front desk
- Air conditioning
- Daily housekeeping
- Front desk safe
- Free WiFi
For families
- Free cribs/infant beds
- Connecting/adjoining rooms available
- Private bathroom
- Separate bathtub and shower
- Daily housekeeping
- Iron/ironing board
What's around
- In Bosques de las Lomas
- Expo Bancomer Santa Fe (2.2 mi / 3.5 km)
- Centro Santa Fe (2.6 mi / 4.2 km)
- Anahuac University (3 mi / 4.8 km)
- Chapultepec Park (6.2 mi / 9.9 km)
- French Embassy (5.9 mi / 9.5 km)
- Auditorio Nacional (6 mi / 9.6 km)
- Parque Zoologico de Chapultepec (6.7 mi / 10.8 km)
- Castillo de Chapultepec (7 mi / 11.3 km)
- Monumento a los Ninos Heroes (7.1 mi / 11.4 km)
- The Angel of Independence Monument (7.1 mi / 11.5 km)
Live Aqua Urban Resort México, Mexico City
Hotel Info: (02) 8228 1927from A$241
- Master Suite, One King Bed
- Deluxe Room, 1 King Bed
- Deluxe Double Room, 2 Double Beds
- Executive Suite, 1 King Bed
More great choices
At a glance
Key facts
Hotel size
- This hotel has 135 rooms
- This hotel is arranged over 5 floors
- Check-in time starts at 3 PM
- Check-out time is noon
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Children (12 years old and younger) stay free when occupying the parent or guardian's room, using existing bedding
- Pets not allowed (service animals welcome)
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle (available on request) *
- Valet parking *
In the hotel
- Cooked-to-order breakfast daily (surcharge)
- Restaurant
- Bar/lounge
- 24-hour room service
- 24-hour fitness facilities
- Full-service spa
- Spa treatment room(s)
- Number of meeting rooms - 7
- Conference space
- Meeting rooms
- 24-hour front desk
- Dry cleaning/laundry service
- Luggage storage
- Wedding services
- Multilingual staff
- Number of buildings/towers - 1
- Year Built 2012
- Elevator/lift
- Safe-deposit box at front desk
In the room
- Air conditioning
- Minibar
- Coffee/tea maker
- Slippers
- Iron/ironing board
- Pillow menu
- Blackout drapes/curtains
- Turndown service
- Private bathroom
- Separate bathtub and shower
- Hair dryer
- 46-inch LCD TV
- Cable TV channels
- Desk
- Free newspaper
- Free WiFi
- Phone
- Daily housekeeping
- In-room safe
- Connecting/adjoining rooms available
Recommended hotels
Special features
Feel Spa by Aqua has massage/treatment rooms and couples treatment room(s). Services include deep-tissue massages, hot stone massages, sports massages, and Swedish massages. A variety of treatment therapies are provided, including aromatherapy, hydrotherapy, and reflexology. The spa is equipped with a sauna, a spa tub, and a steam room.
Guests under 16 years old are not allowed in the spa.
DiningLive - Overlooking the garden, this restaurant specializes in Mexican cuisine and serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar.
Live Aqua Urban Resort México, Mexico City's small print
Also known as
- Live Aqua Mexico City Hotel & Spa
- Live Aqua México City Hotel Mexico City
- Live Aqua México City Hotel
- Live Aqua México City Mexico City
- Live Aqua México City
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Guests under 16 years old are not allowed in the spa.
Reservations are required for massage services and can be made by contacting the property before arrival at the number on the booking confirmation.
The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Optional extras
Valet parking is available for an extra charge
Airport shuttle service is offered for an extra charge
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.
Is the description of this hotel not correct? Tell us


text:
About a year ago, Ned Colletti returned to Los Angeles from baseball's winter meetings in Dallas feeling slightly embarrassed.
He knew things weren't right with the Los Angeles Dodgers, that they weren't operating the way a professional sports franchise should.
While other teams found the time and, more important, the money to treat their employees at the winter meetings to a posh dinner at a swanky joint, Colletti could do no such thing. Under previous owner Frank McCourt, the Dodgers couldn't even take their scouts and executives to a meal because the team was under the financial death grip of bankruptcy. Colletti basically went to the meetings with nothing more than identification and lint in his pockets.
McNeal: Impact of Greinke agreement with L.A.
In the hotel lobby and bars, other general managers would say hello to Colletti and move on. They knew the Dodgers couldn't spend any money, so they pretty much left Colletti and his team alone at their table.
A year later, that embarrassed feeling is gone and may never return.
Colletti was the belle of the ball at the meetings in Nashville, Tenn., last week. He took Dodger employees to a big dinner at Morton's Steakhouse. So many other general managers were lining up to buy him drinks, it wouldn't have been a shock to see filled glassware stacked four deep on his table. The seemingly bottomless pockets of new ownership group Guggenheim Baseball Management will do that for a guy.
Those pockets have also allowed this: paying $2.15 billion for the team; taking on $250 million in salary last August to acquire Adrian Gonzalez, Carl Crawford and Josh Beckett from the Boston Red Sox; paying an unproven Cuban outfielder, Yasiel Puig, $42 million; signing a decent right fielder, Andre Ethier, to an $85 million extension, and paying star center fielder Matt Kemp $160 million in another extension.
On Saturday, they allowed Colletti to hand right-hander Zack Greinke a six-year, $147 million deal, the largest contract ever given to someone who pitches with that arm. That move brought the team's payroll to about $210 million; the luxury tax bumped it to more than $233 million.
Hours later on Sunday, the Dodgers pushed that number even farther north when they agreed to terms with South Korean lefty Ryu Hyun-jin for $36 million over six years. That deal came after L.A. posted a $25.7 million fee just to negotiate with Ryu.
News: Ryu, Dodgers beat deadline
The Dodgers are now the most expensive team in the history of professional athletics, and they now have the heaviest expectations they've ever had to carry in the rich history of their organization.
Their options for 2013: Win the World Series or completely fail.
"They might not want to come out and say that, of course," one National League scout said, "but ownership has to be thinking that."
The Dodgers have done too much too fast for this not to be the case. In less than five months the team has regained the trust of its fan base, traded for or signed for this season players with 15 combined All-Star Game appearances, raised payroll by approximately $138 million since the ownership change, brought on hatred by opposing fans and even executives, and turned their own fans from appreciative to expectant.
But this is what Guggenheim Baseball Management wanted. It wanted the Dodger brand to represent excellence, and while it hasn't yet done that, it does now signal massive dollar amounts. Forget the Yankees of the West. The Dodgers have just catapulted into a completely different stratosphere when it comes to money, the likes of which the Yankees can only hope to match.
The Linemakers: Dodgers' World Series odds improve with Greinke
People can scream all they want about how the Dodgers "overpaid" for Ethier or Greinke or Ryu, but that doesn't matter when the money is endless. Guggenheim Baseball Management operates as if it has a massive orange tree in its back yard (i.e., the team's upcoming television deal) and someone has offered it a coconut (something it doesn't have but desires, like pitching) for half the oranges on the tree. The Dodgers can pay that and won't be hurt if that coconut is rotten; more oranges will grow and they'll have more to spend.
The Dodgers don't operate under the same rules as anyone else in baseball. Damn overpaying. Damn a luxury tax. Damn not winning a World Series for a lack of resources.
But while the Dodgers can ignore the monetary figures, fans don't forget salaries, and they pin expectations directly to them. If Alex Rodriguez made $12 million to $15 million a season, his production would be acceptable, and most years it would be pretty good. But fans know what a player makes each season; the information is just a few Internet clicks away. If he doesn't live up to that paycheck in their minds, he's a bum.
Because of that, Dodger fans will expect the team to run away with the division and burn through the playoffs. Next summer and fall hold the team's fate, but what is known now is that the Dodgers didn't spend stupidly.
The lineup is good. The rotation and bullpen are good. Obviously those "goods" don't add up to a championship, but any general manager in the game would like that as a starting point, and the Dodgers might not be done adding.
Times have changed for Ned Colletti and the Dodgers. Let the steaks sizzle and the drinks flow.


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Torrington: The Arts Desire owners have big plans for the holidays downtown
Published 12:00 am, Tuesday, November 27, 2012
TORRINGTON>> Downtown's newest small business, The Arts Desire, represents a dream realized for sisters Lisa Stepler and Jessica Washington. Since they opened in October, the store owners say they're making their mark in the city.
Lisa Stepler has spent 12 years making hand-painted children's furniture, with items ranging from toy boxes to time-out chairs. The reaction to her work, from friends and customers, inspired her to take it a step further.
"My sister does hand painted children's furniture, and people loved it," said Washington. "It's been a dream of my sister's to do this."
Once the idea to open the store was set, Stepler and Washington worked with a real estate agent who suggested collaborating with ArtWell Gallery, a longtime art presence in Torrington, to share a space. ArtWell offers classes to the public. By sharing a space, students and visitors have the opportunti to purchase their art supplies from the new store.
Located on the corner of Main Street and Water Street, The Arts Desire sells all handmade items by local artisans -- home decor, jewelry, scarves, hats, painted toy boxes, photography, cutting boards, vases, candles, art supplies and much more.
Since they opened, the sisters have heard some positive feedback from the community.
"(Customers) really love the "gifty" things," said Washington.
The art supplies section will be expanded to balance out the home decor selection, and provide more supplies to those taking classes with ArtWell.
As their customer base grows, they'll provide more of a selection, basing their inventory on what's needed.
"People are coming in for art supplies and we want to build that off more and expand," said Washington. "We take notes on what supplies people buy."
Last Saturday, Torrington and other towns and cities around the nation took part in Small Business Saturday -- a way to extend the Thanksgiving night/Black Friday holiday shopping kickoff with a focus on small businesses. The sisters said they were happy with the success of the day.
"Thank you to all the people that came out and for the phenomenal showout for Small Business Saturday," Washington said.
To keep up the momentum, Stepler and Washington are hosting a Christmas Extravaganza on Saturday, Dec. 8 from noon to 5 p.m. Other downtown merchants are also hosting events and sales that day.
At the Arts Desire, the sisters are providing a coupon booklet, a visit from Santa Claus, and elves reading "The Night Before Christmas." A mailbox for letters to Santa, complete with special holiday stationery, will also be offered.
"We wanted to make shopping fun," said Washington.
The Arts Desire is also hosting a Holiday Night Out on Dec. 14 from 5:30 to 9 p.m. Four local artists have been invited to showcase their latest work, including former Brazen Betties owner Julia Sloan, Jenny Maher from Loveycraft, Kate Stephen from Kate Stephen Jewelry and Asa Gleek Designs.
They'll also hold a toy collection drive, and are asking guests to bring a new unwrapped toy, which will be donated to Friendly Hands Food Bank.
"It's going to be a great night. We're just hoping to get people down here for a shopping experience," said Washington.
The Arts Desire is open Tuesday's through Saturday's 10-7 and Sunday's 12-5.
Reach Nikki Treleaven at (860) 489-3121 ext. 324


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Corte Madera, Calif. -- Restoration Hardware Holdings Inc. reported Friday a loss of $28.4 million for the quarter ended Feb. 2, compared with a profit of $24 million in the year-ago period. Results, impacted by costs associated with the company's November 2012 IPO, edged analysts' expectations.
Revenue surged 30% to $398.1 million from $305.2 million last year, beating Wall Street's forecast of $390.5 million. Same-store sales advanced a hefty 26%.
The company has rebranded itself as RH and has moved its focus from Americana goods to high-end furnishings – a move the retailer says will pay off.
"We are well positioned to continue to gain market share and further disrupt the highly fragmented home furnishings marketplace," said Carlos Alberini, CEO.
For the year, net loss totaled $12.8 million, compared with a profit of $20.6 million in the prior year. Revenue rose 25% to $1.19 billion.
Looking forward, the company expects a loss in the first quarter, but is forecasting a profit for the fiscal year.


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RoGallery.com is an established art dealer and gallery located in New York City for over 30 years. We occupy a 10,000 square foot building that holds our extensive collection of select artworks of original paintings, prints, photographs, & sculpture.
Customers that are within driving distance or visiting New York City are encouraged to visit our gallery (by appointment). We are always interested in buying Estates, Private and Corporate Collections. Additional services we provide include auctions, consignment, packing & shipping, framing and appraisals.


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Pretoria – Kaizer Chiefs coach Stuart Baxter believes his side was fortunate to come away with a goalless draw against Mamelodi Sundowns in their Premiership clash at Loftus Versfeld on Tuesday evening.
"It's one of those old clichés, a game of two halves," Baxter said after the game.
"I was happy to go in at half-time on even terms and in the second half, I was very pleased with the response that the players gave.
"Especially the players that have just come back from the national team, because I knew they were struggling a little bit."
The fixture was the first for either side since December 19, after the Africa Cup of Nations enforced break.
Baxter included all seven returning Bafana Bafana players in his starting line-up, while Sundowns coach Pitso Mosimane started both Wayne Sandilands and striker Katlego Mphela.
The Chiefs coach said his decision to field all returning national team players was taken in order to get them back into the right mentality and he wanted to get the players focussed on their club aspirations, following the Cup of Nations tournament.
"The decision to throw all of the boys (Bafana players) in at the same time, the rationale behind it was that I didn't want to give them any sort of space for an excuse," Baxter explained.
"I don't want to tell them that they are tired. I want to say, 'if you think you can play tonight, you can play. If you don't think you can play, then you probably can't play'."
The point puts Chiefs in danger of relinquishing top spot, as defending champions Orlando Pirates – who take on SuperSport United on Wednesday – have the opportunity of reaching the summit of the league standings, should they claim all three points at the Orlando Stadium.
Baxter, however, said the thought had not crossed his mind.
"To be honest to myself and the players, to be working out all of the different permutations – if we win and if they lose – that's me with one eye on somewhere else," he said.
"We've got between now and the end of the season, and if we take more points than anybody else, then we win the league."
Meanwhile, Mosimane said the Brazilians were pleased to walk away with a point, considering that they had played the log-leaders, but would continue to move forward as they looked to get back to winning ways in the second half of the season.
"It was a good display of football," Mosimane said.
"It's not an easy game, it was a tough game, two strong teams and you could see the experience of Kaizer Chiefs."
Mosimane praised Amakhosi and Bafana goalkeeper Itumeleng Khune for a terrific display, ranking Khune as South Africa's number one shot-stopper.
"I think Itumeleng Khune is number one in South Africa, he is unbelievable," Mosimane said.
"Two great saves he pulled out and he is the best...he is on top of his game."
Mosimane said although he remained unbeaten as Sundowns coach after five fixtures, the statistic meant little if the team was not winning.
"The unbeaten story, it sounds good," he said.
"But what's the point of getting two points out of six points? Sometimes when you lose a game, you learn from that game.
"If you ask me, over the last two games, I'd rather have lost one and won one, than two draws."
In Tuesday's other fixtures, Free State Stars romped to a 3-0 victory over Chippa United at the Charles Mopeli Stadium, Bidvest Wits claimed a 2-0 win over Black Leopards at the Peter Mokaba Stadium in Polokwane, while AmaZulu and Maritzburg recorded the second goalless draw of the night at the Moses Mabhida Stadium in Durban. – Sapa


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A Painesville man was arrested after leading police on a chase Sunday morning through Eastlake and Willoughby.
At 5:20 a.m., an Eastlake Police officer initiated a traffic stop for a minor violation on Vine Street driving eastbound, according to the Eastlake Police Department.
The 1999 Chrysler Cirrus did not stop and drove under Route 2. Turning left onto the entrance ramp to Route 2 eastbound, the vehicle went off the side of the road, police said.
According to the crash report filed by Willoughby Police, the right front side of the car struck a light pole, causing the pole to fall.
The driver, identified as 33-year-old Dieare Williams, at first appeared to be unconscious, but then he exited the car and tried to flee on foot, police said.
Williams was transported to Lake Health West Medical Center by the Eastlake Fire Department and later transported to MetroHealth Medical Center in Cleveland, police said.
He was charged with fleeing and eluding police, driving with a suspended license, marijuana possession and a seat belt violation, according to court records.
Williams, who was treated and released from the hospital, is scheduled to be arraigned Tuesday in Willoughby Municipal Court.


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Reagan girls finally bound for Austin
Updated 9:09 pm, Sunday, February 26, 2012
In his six seasons at the school, Reagan coach Terry Barton had turned the Rattlers into consistent winners that could never get over the proverbial hump.
But this season, they finally put it together by getting past the second round for the first time in history and setting a school record for wins.
Reagan now has a shot at a state title. The Rattlers (34-4) play Spring Dekaney (39-1) in the Class 5A state semifinals at 8:30 p.m. Friday at the Erwin Center in Austin.
"It's kind of just finally hitting me, just how special it is," Barton said Sunday. "Last year we won 28 games, but we kept stumbling in the second round and coming up short."
The fact that Reagan had to beat Wagner to advance to the state tournament made it even sweeter. The Thunderbirds have been the class of the area in recent years with two trips to the state tournament since 2008, including last season. Reagan beat Wagner 61-46 in Saturday's regional final at UTSA.
"That actually makes it a bit more special," Barton said. "It's only fitting that we had to beat them, because they've been the pinnacle of the region."
Sports Channel
Now the Rattlers will try to do something not even Wagner has done: win a state title. No San Antonio-area team has won a Class 5A title, and just one (Taft in 2002) has been to the championship game.
That won't be an easy task against Dekaney. The Wildcats boast two players signed with major colleges — Alexis Durley (Cincinnati) and Shunta Nevitt (Texas Tech) — along with uncommon depth. Five players average at least 9.7 points per game.
But Barton believes his team has been prepared by its rugged playoff run. To get to state, Reagan beat four area Top 10 teams, including two district champions (Steele and O'Connor).
Unlike Reagan, Poth will be in familiar territory in the Class 2A state tournament. The Pirettes (28-8) are making their seventh trip to state in the past 10 years, and 10th overall. They won state titles in 2007 and 1997. Poth faces Edgewood (31-6) in the semifinals at 10 a.m. Friday at the Erwin Center.
Twitter: @mysahighschools
More Information
UIL state girls basketball tournament
When, where: Thursday-Saturday, at Erwin Center in Austin
Tickets: $12 per session, $75 for all-tournament pass
Friday's semifinals: Duncanville (38-1) vs. Houston Cypress Falls (37-2), 3:30 p.m.; Reagan (34-4) vs. Spring Dekaney (39-1), 8:30 p.m.
Saturday's championship: 8:30 p.m.
Friday's semifinals: Brock (33-5) vs. Tuscola Jim Ned (30-8), 8:30 a.m.; Edgewood (31-6) vs. Poth (28-8), 10 a.m.
Saturday's championship: 2 p.m.


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MADISON - Forget about John Henson's 15.8 points per game, his nearly 10 rebounds per game or three blocks per. Don't even think about his 56.2 percent shooting clip from the field or his ability to get to the free throw line.
That's just the blueprint to his success.
Spend a second thinking about his 6-foot-11 frame, his 7-foot-5 wingspan and his ability to help that up-tempo, recently removed No. 1 and currently No. 5 ranked North Carolina squad.
How in the world will Wisconsin defend that?
"It's hard for us to simulate it," UW assistant coach Lamont Paris said. "It's hard and it's something that's almost impossible to simulate."
Short of waving around broomsticks, or having the Badger student managers synchronize a trampoline routine in front of the rim, there simply is no way to accurately practice against the length of North Carolina.
Henson, as mentioned, goes 6-foot-11. The Tar Heels also have 7-footer Tyler Zeller, 6-foot-9 James McAdoo, and 6-foot-8 Harrison Barnes. Even their guards (Dexter Strickland and Kendall Marshall) stand 6-foot-3.
They all can and will run.
"You can't simulate their length, jumping ability or any of that," junior forward Ryan Evans, set to match up with one of Carolina's versatile bigs, said. "I've played against a lot of NBA guys back home.
"I know what's to be expected."
But expecting something from this uber-athletic North Carolina team and realizing what its capable of are two entirely different animals. Unfortunately in the case of Wisconsin, there will most definitely be times when a shot is deflected, a rebound is had or a passing lane is jumped that UW didn't anticipate.
"That's why we've just got to stick to our rules," UW sophomore guard Josh Gasser said. "Guards have got to get back on defense and bigs have to follow up. The more we get our hands on balls the harder it is for them to go up, get it and get on the break.
"If we can tip the ball around a little bit and just get hands on balls it should really limit their transition break."
Wisconsin does have Evans. And it does have the ultimate energy and glue guy Mike Bruesewitz who will assuredly muck it up down low. Jared Berggren is a legit 6-foot-11 and somewhat agile player, particularly in the post.
UW's bigs can move a little bit, too. But they'd prefer not to get into a track meet with a team that strives for that type of play, particularly in their environment.
"We're not small," UW senior point guard Jordan Taylor said. "We have guys who are pretty long in Evan Anderson and guys we've played against in the summer. It's nothing we haven't seen before.
"It will be a fun challenge."
Fittingly, Wednesday's game will likely be one of the determining contests in the annual Big Ten/ACC Challenge. It will definitely come down to whatever team asserts its style over the other.
The transitional game is something North Carolina prides itself on. Wisconsin, at the same time, is all about team defense and forcing opponents out of their respective comfort zone.
Something will have to give.
"The more we can play our style instead of theirs it's obviously beneficial for us," Gasser said. "That just comes with us running good offense, getting good shots and hopefully knocking them down. Then it's just us doing our own thing on defense. We know they've got talent.
"We're not going to get caught up in that."


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Stocks' Santa Claus Rally Hits a Fiscal-Cliff Speed Bump
How close are we do a budget deal down in Capitol City? It doesn't sound all that close.
Markets were treated to a couple of dueling pressers this morning, from House Democratic Leader Nancy Pelosi and House Speaker John Boehner. Boehner, who just yesterday said he was "the most optimistic man in this town," didn't sound very optimistic today. He again charged that President Obama is not serious about cutting spending, and said the White House appears willing to go right to the edge of the fiscal cliff.
This comes after Pelosi said that, given the timing of the holidays and the timing necessary to move a bill through the Legislative Branch, Congress actually had only a couple of days left to get a deal done.
The Dow is now down about 31 points at 13213, after surrendering an 80-point rally yesterday afternoon and closing flat. The S&P 500 is off 4 at 1424, and the Nasdaq Comp's down 8 at 3005.


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A new organization is taking aim at a buyout of California American Water's Monterey district system.
Public Water Now formally announced this week it would sponsor a ballot initiative seeking voter approval to purchase Cal Am's local assets. It would appear on the June 2014 ballot.
Ron Cohen, president of Public Water Now, said the organization was just beginning the process of qualifying the initiative. It would require the Monterey Peninsula Water Management District to purchase Cal Am's local assets, including through the use of eminent domain if necessary.
Cohen, who lives in Pebble Beach, said a draft petition has been created and the organization was seeking to hire an attorney to offer advice about how to proceed. He said a signature-gathering effort would likely begin by early July and would seek to collect 6,500 signatures by November, enough to qualify the initiative for the ballot with a 10 percent margin.
While the organization includes members and participants from other groups pushing public ownership of the Monterey Peninsula water supply — such as WaterPlus, Citizens for Public Water and Ratepayers First — Cohen said the new group will maintain a sharper focus on purchase of the local water system.
"We are only focused on a Cal Am purchase and no other issues," he said, adding other groups have become involved in other issues, such as participating in the state Public Utilities Commission review of Cal Am's proposed Peninsula water supply project, supporting alternative projects or debating growth.
"I'm insisting all other issues, other than purchasing Cal Am, be checked at the door," he said. "When it comes to the water issues, there's been far too much conversation."
On Thursday, Cohen argued Cal Am has essentially forced a public purchase of the local system by mismanaging the quest for a new water supply for the Peninsula, needed because of a state order to cut back on pumping from the Carmel River, and raising the spectre of doubling or even tripling water bills in the near future.
Cohen, who wrote a commentary in The Herald last week arguing for a public purchase, said a new financial feasibility study indicates Peninsula residents could afford to buy out Cal Am's local system simply by eliminating the company's profit — which he estimated would triple by 2018 if it remained the Peninsula's sole water provider — taxes and PUC fees.
Cohen said the study estimated savings from cutting out Cal Am at about $340 million and suggested Cal Am's local system could be bought for up to 1.5 times its $125 million book value, or about $187.5 million, though he called that a "high-end offer."
Cal Am spokeswoman Catherine Bowie cautioned that a "public takeover" would result in a "lengthy and expensive eminent domain proceeding that would distract from the real task at hand: constructing a new water supply project to avoid the state water cutbacks."
"At this time, our community needs to be united and focused on developing the solution to our water issues," Bowie said. "It's important to understand that condemnation requires we be paid fair market value for all of our assets. The reality of this proposition is that tremendous additional costs would be imposed upon the public in addition to the cost of developing a new water supply, which will be needed no matter who owns the system.
"In case after case, public takeover proponents offer initial estimates of the cost to purchase a water system that turn out to be a fraction of the actual cost. It's important the Monterey Peninsula show state regulators that we are working together to solve the water problem."
But Cohen said it is past time for Cal Am to be replaced, saying it would likely be too late to buy the company after the Peninsula water project is completed because the company would be far more valuable. He suggested the company is not likely to be capable of bringing the project to a successful conclusion.
"This is the third try," he said. "If I was a baseball manager, I would have pulled the pitcher by now. People have to make a decision: Are they going to have more of the same, or make a change?"
In contrast, Cohen praised Dave Stoldt, general manager of the water management district, as one of the best in the state and argued he would be a more efficient manager of the Peninsula water supply than Cal Am.
Cohen said Public Water Now has about 15 members, including some who are well-known in local water politics, like George Riley, Harvey Billig, Doug Wilhelm and Dale Heckhuis. He said the organization has about $10,000 and is just starting its fundraising efforts, along with seeking nonprofit status as a 501(c)4 organization.
WaterPlus president Ron Weitzman said his organization would work independently to supplement Public Water Now efforts, including a reorganization of the water management district, and urged support of the public purchase bid.
Jim Johnson can be reached at 753-6753 or firstname.lastname@example.com.


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A Phase 1 Multicenter Open-label Study to Evaluate the Safety Tolerability and PK of MEDI0680 (AMP-514) in Subjects With Advanced Malignancies
This study is ongoing, but not recruiting participants.
MedImmune LLC
Information provided by (Responsible Party):
MedImmune LLC
ClinicalTrials.gov Identifier:
First received: December 12, 2013
Last updated: March 24, 2017
Last verified: March 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is a multicenter, open label, first-in-human dose-escalation study of MEDI0680 (AMP-514) to evaluate the safety, tolerability, PK, immunogenicity (IM), and antitumor activity in adult subjects with solid tumors.
|Advanced Malignancies
|Drug: MEDI0680 (AMP-514)
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase 1, Multicenter, Open-label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI0680 (AMP-514) in Subjects With Advanced Malignancies
Further study details as provided by MedImmune LLC:
Primary Outcome Measures:
- Safety and Tolerability; define Maximum Tolerated dose [ Time Frame: 1 year ]The primary objectives are to assess the safety and tolerability of multiple doses of MEDI0680 (AMP-514) and define the maximum tolerated dose (MTD) or highest protocol-defined dose of MEDI0680 (AMP-514) in the absence of exceeding the MTD.
|Actual Study Start Date:
|December 19, 2013
|Estimated Study Completion Date:
|August 22, 2017
|Estimated Primary Completion Date:
|August 22, 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Dose arms
Dose Escalation
Drug: MEDI0680 (AMP-514)
Study has planned dose escalation cohorts
|Ages Eligible for Study:
|18 Years to 99 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- At least 18 years of age at time of study entry
- Written informed consent and any locally required authorization (eg, Health Insurance Portability and Accountability Act [HIPAA] in the USA) obtained from the subject/legal representative prior to performing any protocol-related procedures, including screening evaluations
Histologically- or cytologically-confirmed melanoma or clear-cell RCC that are refractory to standard therapy or for which no standard therapy exists
- Subjects must have failed, be intolerant to, or be ineligible for any potentially curative approved treatment, irrespective of line of therapy
- No more than 3 prior lines of therapy
- At least 1 measurable lesion per RECIST v1.1; subjects whose only measurable lesion is a lymph node will be excluded
- Eastern Cooperative Oncology Group performance score of 0 or 1
For all tumor types, adequate organ and marrow function, as defined below:
- Hemoglobin ³ 9.0 g/dL within first 2 weeks prior to first dose of MEDI0680 (AMP-514)
- Absolute neutrophil count (ANC) ³ 1.5 × 109/L (1,500/mm3)
- Platelet count ³ 100 × 109/L (100,000/mm3)
- Total bilirubin ≤ 1.5 × ULN except subjects with documented Gilbert's syndrome (> 3 × ULN) or liver metastasis, who must have a baseline total bilirubin ≤ 3.0 mg/
- Alanine aminotransferase and AST ≤ 2.5 × ULN; for subjects with hepatic metastases, ALT and AST ≤ 5 × ULN
- Serum creatinine ≤ 1.5 × ULN OR calculated creatinine clearance (CrCl) or 24-hour urine CrCl ≥ 50 mL/minute ▪ Cockcroft-Gault formula will be used to calculate CrCl; 24-hour urine CrCl will be derived using the measured creatinine clearance formula
- Prior treatment toxicities must be ≤ Grade 1
Exclusion Criteria:
- Concurrent enrollment in another clinical study, unless it is an observational (non-interventional) clinical study or the follow-up period of an interventional study
- Receipt of any BRAF inhibitor (in metastatic melanoma), or investigational anticancer therapy within 4 weeks prior to the first dose of MEDI0680 (AMP-514)
- Prior exposure to immunotherapy, such as, but not limited to, other anti-CTLA-4, anti-PD-1, or anti-PD-L1 antibodies, excluding therapeutic cancer vaccines
- Major surgery (as defined by the investigator) within 4 weeks prior to first dose of MEDI0680 (AMP-514) or still recovering from prior surgery
- Other invasive malignancy within 2 years except for noninvasive malignancies such as cervical carcinoma in situ, non-melanomatous carcinoma of the skin or ductal carcinoma in situ of the breast that has/have been surgically cured
- Prior allogeneic or autologous bone marrow or organ transplantation that requires use of immunosuppressives
- Unresolved toxicities from prior anticancer therapy, defined as having not resolved to NCI CTCAE v4.03 Grade 0 or 1, or to levels dictated in the inclusion/exclusion criteria with the exception of alopecia. Subjects with irreversible toxicity that is not reasonably expected to be exacerbated by MEDI0680 (AMP-514) may be included (eg, hearing loss) after consultation with the MedImmune medical monitor
- Active or prior documented autoimmune disease within the past 2 years
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02013804
Please refer to this study by its ClinicalTrials.gov identifier: NCT02013804
|United States, Connecticut
|Research Site
|New Haven, Connecticut, United States
|United States, Michigan
|Research Site
|Detroit, Michigan, United States
|United States, New York
|Research Site
|Bronx, New York, United States
|United States, Oregon
|Research Site
|Portland, Oregon, United States
|United States, Tennessee
|Research Site
|Nashville, Tennessee, United States
|United States, Texas
|Research Site
|Houston, Texas, United States
Sponsors and Collaborators
MedImmune LLC
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|MedImmune LLC
|ClinicalTrials.gov Identifier:
|NCT02013804 History of Changes
|Other Study ID Numbers:
D6020C00002 (AMP-514-01) ( Other Identifier: MedImmune )
|Study First Received:
|December 12, 2013
|Last Updated:
|March 24, 2017
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017


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- Due to the handmade nature of these purses and bags, colors and design may vary.
Chili Peppers Tote Bag
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I spent part of the holiday weekend in Kentucky, tasting bourbon, taking pictures of bourbon barrels (which I'll keep to a minimum here) and roaming the streets of Louisville (as a public service announcement, let me tell you right now to stay away from Fourth Street Live no matter what the nice lady at the front desk says).
Though we didn't spend many daylight hours in Louisville, there was enough time to notice a few elements of biking cuture—like this interesting bike rack. Nashville has gotten some flak lately for valuing style over substance when it comes to bike rack installations, but this dragon seems to have both.
And, um, this interesting bike rack, which, having no bikes ourselves, April, Chiara and I decided could do double-duty as a jungle gym.
Louisville does appear to have a Bcycle bike sharing program of sorts—but as far as I could determine from the street, this station at least was only for Humana employees.
Our destination was the 21C Museum Hotel, where we perused the awesome exhibits (and imbibed delicious cocktails). This was our favorite piece of art.
Then we walked over to the Brown Hotel, where we borrowed some sparklers from a wedding reception and had our own little Fourth of July celebration.
Then we decided to pedicab it home. My first ride in one ever!
The Louisville pedicabs have 21 speeds and internal hubs. Our driver certainly seemed to transport us effortlessly—but then, we Southern belles don't weigh more than a cotton boll, bless our hearts.
How was your holiday weekend?


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PUBLIC funding to the Police Federation of England and Wales will be withdrawn from this summer in an announcement which has shocked North Yorkshire officers.
Speaking at the Federation's annual meeting, Home Secretary Theresa May told members the Government would force the changes if needed.
An independent review ordered by the Federation into the operation of the organisation found 36 recommendations which it was currently considering, but Federation bosses in North Yorkshire said yesterday's announcement, came as a surprise and showed little respect for officers.
Mrs May said: "Make no mistake – if you do not make significant progress towards the implementation of the Normington reforms and Federation does not start to turn itself around, you must not be under the impression that the Government will let things remain as they are." Public funding to the Federation, which was £320,000 and reduced to £190,000, will now be stopped completely, with the funds going instead to Police First, which she called "a new scheme designed to attract the brightest young university graduates into the police".
She also said police officers would now have to opt into the Federation, rather than becoming members automatically, and she would change the law to allow the Home Office to access all Federation accounts without question.
Mrs May said she would also recommend that the Federation become subject to the Freedom of Information Act. Her speech was greeted by silence from the hundreds of Federation members present.
Mike Stubbs, incoming chairman of the North Yorkshire Police Federation, said the organisation was committed to the principle of the reforms, but Mrs May's speech demonstrated a lack of respect for officers.
He said: "The speech made by the Home Secretary was sadly indicative of the low regard in which policing is held by the current Government. Thankfully, as recent opinion polls show, the public continue to hold police officers in considerably higher regard than politicians. "It is disappointing that, having previously stated that reform of the Police Federation was a matter for the Police Federation, she has now reneged on that commitment and warned she will impose all the changes contained in the Independent Review.
Even the report's author, Sir David Normington, is on record as saying that he did not expect all of his recommendations to be implemented." Steve Williams, chair of the Police Federation, said: "In all honesty the comments made by the Home Secretary came as a total surprise and I was given no indication of what was going to be said. We have already indicated we are an organisation that is willing to change and it is for us to make the key decisions around reform over the next few days."


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The Clacton coastguard were called to rescue a sinking jet ski.
The Clacton Beach Patrol and the Clacton RNLI Inshore Lifeboat were also called to the jet ski just before 2pm yesterday, which was sinking out from the Gunfleet Boating Club, Holland Haven.
They were helped by the beach patrol and was taken ashore where the coastguard gave safety advice.


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CLERMONT – The leaves are beginning to change and that can mean only one thing—fall is here.
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Goalkeeper Matt Pickens was chosen to represent the Colorado Rapids on the downloadable MLS covers of EA Sports FIFA 13 video game, which was released today. Matt is one of four MLS goalkeepers featured on such covers, along with Chivas USA's Dan Kennedy, Chicago's Sean Johnson, and Sporting KC's Jimmy Nielsen.
The official FIFA 13 launch party happened in New York City on Monday evening at an event that featured Snoop Dogg...err, Snoop Lion, right? Snoop explains here how he became a fan of our beautiful game.
Any fan watching this season seen can attest to what a great year Pickens is having. He's set one milestone after another, and today he gets some much deserved recognition along with the likes of MLS stars Landon Donovan, Dwayne De Rosario, Brek Shea, Freddy Montero, Kyle Beckerman, Tim Cahill and other players who are also featured on the downloadable covers.
Fan can download covers for any of the featured players from Major League Soccer's official Facebook page (CLICK HERE).
To download:
1. Click on the cover photo you prefer. 2. Click "Options" at the bottom of the photo viewer 3. Click "Download" 4. Save to hard drive 5. Print 6. Enjoy!
Here's a few examples of the player celebrations you'll see on the new game:


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The New York Mets haven't made much progress in their contract extension talks with righthander R.A. Dickey and third baseman David Wright, according to the New York Daily News.
There was some speculation that a deal with each might be finalized soon after the end of the regular season, but the newspaper reports the talks remain in the preliminary stages.
In fact, a source told the Daily News that the sides "still talking about when to really get talking."
Dickey, 37, is under team control through the 2013 season, as the Mets have a $5 million option on him for next season. He is coming off a career year in which he went 20-6 with a 2.73 ERA and an NL-best 230 strikeouts. He also led the leg in innings pitched (233 2/3), complete games (five) and shutouts (three). As a result, he was named to the Sporting News' 2012 NL All-Star team and is a front-runner for the NL Cy Young Award.
The Mets have a $16 million option on the 29-year-old Wright for 2013, but he will be eligible for free agency next offseason—barring an extension. Wright hit .306 with 21 homers, 93 RBIs, a .391 on-base percentage and an .883 slugging percentage in 156 games this season.


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since 1951 the publisher of the worldwide unique cross reference manual Key to Steel - Stahlschlüssel, well-known to everyone dealing with steel.
Available as book, CD-ROM (material database including search program for Windows) or as online version (web browser based online material database) ready to decipher / decode the steel materials of the world and find equivalent steels.
Please use above menus to get to the desired areas.


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I WAS ONCE an American fighting man. Well, perhaps better put, I was a clerk typist in the Army. But I always did tell myself that if the enemy ever attacked my office, I'd throw that Underwood typewriter as hard as I could — even if she was unarmed.
I will also confess that — while I am loyal to my country — I was there as a volunteer reservist for the sole purpose of avoiding the draft and spending several years of my life following orders from a squadron of noncommissioned officers with the collective IQ of a salad bar.
I know that our modern volunteer army has upgraded itself greatly, and that the days of being hauled out of bed at 3 a.m. and made to do 50 push-ups outside in subfreezing temperatures by a drill sergeant who had been greatly overserved at the NCO Club are now history.
I am justly proud of our American fighting men and women who have far surpassed my own military skills. Skills that were once described to me by my reserve unit commanding officer as, "Never being able to figure out how someone with a successful civilian job like you can be such a horrible failure as a soldier." My C.O. was both observant and accurate.
So I guess I'm just a little puzzled at how two of our highest-ranking officials — one military, and one retired military — have found the time to engage in more hanky-panky than all of the terrorists, guerrillas and other despicable zealots about whom it is their job to discover hanky-panky.
David Petraeus was a four-star general who was the poster boy for how to look, lead and guide our forces in Iraq and Afghanistan. If a movie company were to cast what a lieutenant general who led the American Forces in the Middle East looked like, the only person they could hire to play Gen. Petraeus was Gen. Petraeus.
And then, in September of last year, Gen. Petraeus was asked — either by central casting or the President of the United States — to retire from the Army and assume the role of director of the CIA.
Ahhh, but here's the story behind the story. Back in 2006, it seems that a Harvard graduate student and Army reservist — the married mother of two children embarked upon a case study of Gen. Petraeus' leadership of the Iraq war. It then grew into the writing of a biography in which she gained unprecedented access to both Petraeus and his commanders — and apparently to his personal stash of silk jockey shorts along with first-person knowledge of his annoying habit of snoring on his left side.
Ultimately, this led to a CIA investigation — which was his bailiwick, and he summarily fired himself. And his biographer.
Enter John Allen, an unretired general who was about to be named the top commander of American troops in Afghanistan. Now it seems Allen was enmeshed in this whole escapade himself. Apparently, he was somehow smitten with a married socialite who bears a vague facial resemblance to Heidi Fleiss. Smitten to the effect of 20,000 to 30,000 pages of emails and other documents written to the socialite Jill Kelley between 2010 and 2012. I am not very good at math, but that's an awful lot of emails a day.
Beyond all that, the biographer was busy writing "keep away from my man" notes to Kelley, who didn't notice because she was too busy reading emails from the general.
There's a lesson to be learned here:
Power corrupts.
Learn how to tweet — you have to keep it to 140 characters and it still leaves you time to both manage the troops and lust after a Heidi Fleiss look-alike.
And as a bonus, you get to live in Afghanistan.
Now, look what you've missed.
Barry Tompkins is a longtime sports broadcaster who lives in Marin. Contact him at email@example.com.


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Humans started majority of weekend wildfires
COTTAGE GROVE, Ore. - Dozens of wildfires kept crews busy this weekend, including two in the South Lane County Fire and Rescue district that burned a combined 10 acres.
Wildfire managers across the state battled at least 65 wildfires over the weekend. People burning debris were responsible for at least 36 of the 65 wildfires reported, according to Keep Oregon Green Association.
The South Lane fires remain under investigation.
Firefighters quickly contained a fire in the 76000 block of Martin Creek Road. A second fire in the 75000 block of London Road kept firefighters busy until Saturday evening.
Oregon Department of Forestry and Weyerhaeuser Inc. assisted South Lane Fire with ground crews, water trucks and a helicopter.
The fires remain under investigation.
South Lane firefighters said a lack of rain this past spring has made fire conditions extreme earlier than usual.
"We're pulling firefighters from other agencies to help," said Craig Pettinger with Oregon Department of Forestry. "It feels like August, not May."
Many fire districts have temporarily suspended backyard and debris burning. Keep Oregon Green recommends you contact your fire district or the local Oregon Department of Forest for current conditions and restrictions.
The tips for safe backyard burning include:
- A charged hose must reach to and all away around the burn pile.
- The 10-foot cleared area around the pile should be kept wet at all times.
- Use a shovel or rake handy.
- If burning is allowed, keep your burn pile small adding to it as it burns down.
- Stay with the fire at all times.
- Only yard debris is legal to burn - no garbage or lumber.
- Once the debris is burned, soak the area of and around the burn.
- Check on it frequently to make sure no sparks remain.


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The Chaffey Community Republican Women's Club is seeking applicants for its Mousel Scholarship award for graduating seniors attending a school in Ontario, Montclair, Upland, San Antonio Heights or Rancho Cucamonga.
Students will be asked to write an essay on the U.S. Constitution. The club award is $1,000.
That winner then will go on to compete in the division's award for a first place amount of $1,500, with second place $1,000.
For details: 909-947-5311 or email email@example.com.


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Go Hero X Executive Replicas' Next 1:6 "Pulp" Action Figure...
As announced back in September (see our story HERE), Go Hero, in conjunction with Executive Replicas, had revealed their next 1:6th scale "pulp" action figure will be Doc Savage. The man of adventure, who started life in American pulp magazines during the 1930s, joins previously released pulp hero figures Flash Gordon and The Shadow.
Pictured above is a first look (work in progress) at one of two (2) Doc Savage head sculpts, this one representing his "Golden Age" look made famous on the pulp covers. The "Man of Bronze"? More like the Man of Gold! The other head sculpt will reflect Doc Savage's "Silver Age" and can be seen HERE. Both stunning head sculpts were created by talented Go Hero friend and artist Gabriel Marquez (pictured below).
Go Hero is currently in discussions on a possible Doc Savage exclusive. If an exclusive deal pans out, this "Golden Age" look will be its head sculpt. If not, the figure will ship with two heads. Full details to be announced in the coming weeks.
Amazing head sculpts aside, the 1:6 Doc Savage figure promises to impress in other areas as well. Go Hero states that they are going all out on this figure, Doc Savage featuring metal and leather accessories, multiple guns, defined muscle body and more. We'll keep you posted on any breaking developments, including planned release date and pricing... stay tuned!
Check out Go Hero and Doc Savage on their official Facebook page.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.
Sculptor Gabriel Marquez


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The dish on Long Island's restaurant and food scene.
Spring doesn't arrive for another two weeks, but things are already warming up for Long Island's barbecue community. WilliePallooza, the season's first big BBQ event, takes place at the Brentwood VFW on April 6 and 7.
WilliePallooza is named for Long Island's most decorated barbecue champion Will Breakstone. The proceeds from this year's event will benefit the West Islip Breast Cancer Coalition. Barbecuing teams are invited to sign up to compete. The fee is $258 per team to compete for BBQ, plus $28 for the chili contest.
Judges and volunteers are also needed; you'll need to sign up in advance. Find all the details and applications at williepallooza.com. This is a New York State BBQ championship and will be governed by BBQ Brethren Rules.


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From release
Gary Parsons was elected potentate of the Hejaz Shriners at the annual election held Saturday, Jan. 5.
Hejaz has 4,851 members and the Shrine Center is located on Ranch Road in Mauldin, which also hosts an 18-hole championship golf course on about 300 acres.
Parsons was born in Georgetown and educated in the Georgetown school system where he graduated from Winya High School in 1956.
After serving in the U.S. Army, Parsons moved to Lancaster, where he still resides today.
Beverly Lane Lorenz
For The Lancaster News
The entire Indian Land community can now enjoy the major landscaping project at the Del Webb Library at Indian Land.
"I have the most wonderful news," said Carol Williams, president of the Sun City Carolina Lakes Mums & Poppies Garden Keepers Club, who made this project their mission.
"A very generous donation from one of our members was just received (last fall). This donation put us over the top. We have reached our goal of $6,246.99.
Hall finishes basic training
U.S. Air Force Airman Michael L. Hall recently graduated from basic military training at Lackland Air Force Base in San Antonio, Texas. During the eight weeks of training, he completed intensive training in military discipline and studies, Air Force core values, physical fitness and basic warfare principles and skills.
Airmen who complete basic training earn four credits toward an associate in applied science degree through the Community College of the Air Force.
Dr. Martin Luther King Jr.'s birthday is clearly a reason to celebrate; and, bringing the Indian Land community together because of it is all the more reason.
On Jan. 20, Steele Hill AME Zion Church joined Sun City Carolina Lakes in celebrating with prayers, songs and reflections, followed by a gathering with refreshments in the Lake House ballroom at Sun City.
SCCL Lifestyle Director Trevor Sunderlage said he and a committee of homeowners "put the program together with the idea that we would celebrate MLK's legacy."
FORT MILL – As the weekends slowly begin to warm into spring, families find themselves searching for close-to-home recreational activities they can enjoy outside together.
If you are looking for a place where you can relax and enjoy the serene beauty of nature and leave the hustle and bustle of the real world behind you, you don't have to go far.
Just a short distance away, the Anne Springs Close Greenway is waiting.
The Native American Studies Center expanded its art gallery just before Christmas with a gift made possible through an anonymous donor. Catawba Indian Chief and subject of many Catawba creations, King Haigler, rules once again in clay in a still-life painting by Greenville artist, Nancy Biggs Thomas.
Center Curator Brittany Taylor said the work was excellent, with vibrant complementary colors highlighting two traditional King Haigler pots.
She was delighted to welcome Thomas's work to the Center's collection.
When Marty Stuart comes to Lancaster on Saturday, Feb. 9, he will be joined by some familiar faces.
The Hinson Girls, a bluegrass and gospel band from Van Wyck, were asked by the Lancaster Performing Arts Series to be the opening act for Stuart's concert at the University of South Carolina Lancaster's Bundy Auditorium.
Have you ever thought of buttermilk as being mysterious? Does its mere mention make you shake in your oven mitts, the James Bond theme song playing in your head?
Oh wait, maybe it's just me.
For years, this humble ingredient has had me stumped.
What do you do with it? Is it for baking or am I supposed to put it in savory dishes?
The answer, it turns out, is a simple "yes."
A Charlotte radio station is joining with a local care center to provide relief for mothers in need.
New Life 91.9, a Christian radio station based in Charlotte, will host their annual Carolina's Biggest Baby Shower at the Pregnancy Care Center in Lancaster, 718 S. Main St., from noon to 7 p.m. Wednesday, Jan. 23.
The shower is a drop-in event, and people are welcome to bring a gift, tour the center and meet staff from both the care center and New Life 91.9.
Well, the crisis on the verge of bringing America to its knees has been averted for now.
No, I'm not talkin' about the fiscal cliff. I am referring to $8 a gallon milk.
I heard a recent TV news report that milk is gonna be more expensive than bottled water, so given the television source, it must be so.
First taxes, now milk.
Copyright © 2017
The Lancaster News is your source for local news, sports, events, and information in Lancaster County and Lancaster, South Carolina, and the surrounding area..


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Backwards or ForwardsRiddles are little poems or phrases that pose a question that needs answering. Riddles frequently rhyme, but this is not a requirement.
Whether backwards or forwards I'm read,
It matters to me not a bit.
I am gentle and light, and transposed
I am ever ready and fit.
HintThree letter word requiring three answers.
AnswerPAT, TAP, APT.
What Next?
See another brain teaser just like this one...
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If you become a registered user you can vote on this riddle, keep track of
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Article Post
Director of Utilities and Smart Grids, Alvarion
Navigating the Smart Grid Middle Mile
As utilities and municipalities continue to build out their grids, the technology choice connecting the "middle mile" to networked devices will become increasingly critical. Unfortunately, they are faced with options that leave them caught between two conflicting imperatives. On one hand, they want to deploy a private smart grid network that can be tightly controlled. On the other, utilities desire the simplicity and availability of public operator networks.
4G and the Middle Mile
Utilities and municipalities are looking to enhance the way power is delivered and consumed, in order to improve efficiencies, drive down costs and enable integration of renewable energy sources.. However, the majority of the current smart grid network infrastructure was built with just one application in mind - reading meters - and cannot meet the long term bandwidth, low latency and QoS (Quality Of Service) that new services will add to the network.
The middle mile segment of the network, plays a dominant role of connecting multiple Smart Grid sub networks, such as Smart Metering Neighborhood Area Network (NAN), Field Area Network (FAN) covering distribution automation devices and mobile work force, and Substation Automation backhauling. However, the mesh networks or PLC (Power Line Communication) covering the last mile (from homes to pole tops) and the connected devices on the neighborhood area network (NAN), is currently traversing narrowband networks with rather high latencies. Unfortunately, this limited connectivity is not suited to flexibly address the requirements of the new era of services slated to hit the smart grid in the next five to 10 years.
The next generation of smart grid networks demands low latency high bandwidth and QoS to support activity such as monitoring grid assets through applications such as video, allowing contact center agents to quickly access customer data remotely or delivering mobile broadband to technicians reading data across the service territory. Having a 4G network will not just be "nice to have" but is a necessity in future-looking environments where bandwidth demands will soar and multiple applications will each have diverse requirements of their own.
Public versus Private
Generally speaking, private networks provide greater control, reliability, performance, return on equity (ROE) and coverage. As for public networks, utilities and municipalities can take advantage of availability, managed services and smaller initial investment benefits. However, the debate between selecting public or private 4G infrastructure is complicated by the fact that there are various approaches within those parameters:
- Public network - Public cellular networks are often ideal for running pilot programs because utilities can obtain communications as a service. No internal expertise or costly network build-out is required when leveraging public capabilities. Drawbacks of this approach include lack of control, coverage limitations (especially to outer edges of the territory) and no ROE, which could impact rates and the utility business objectives. Security is also a major concern and can only be as stringent as the service providers ensure.
- Non-cellular Public network - The major advantage of non-cellular networks, such as wireless ISPs, is that they don't accommodate the needs of mobile subscribers. While cellular networks cater to revenue generating subscriber demands, which could lead to disconnections and delays in utility network coverage for the smart grid, wireless ISPs are able to deliver 4G service without disruption.
- Private utility built network - Building a wireless network from the ground up can be more costly but it provides added control and ROE. Utilities can rest assured knowing the network is properly maintained according to utility protocols and industry standards. As a result, utilities can deliver enhanced performance with guaranteed QoS and service level agreements (SLAs), as well as comply with utility communication standards. While most projects start with small pilots, utilities should be careful in selecting the wireless vendor and ensure that it brings the years of experience and size of deployments that the Smart Grid project will eventually end up with.
- Private City/cooperative owned network - There are currently over 900 electric cooperatives in the United States responsible for the distribution of power and some large cities that own the power distribution company that could potentially provide the network infrastructure for Smart Grid. Deploying a "Smart City" network infrastructure, owned by the city/co-op, can provide "Smart Grid" connectivity as well as connectivity to other municipal services such as public safety, Smart Traffic that reduces gas emissions, Smart Lights that reduce costs, and internet access to underserved population, helping promote education and create new jobs, The challenge is to select a wireless vendor that has the experience in building Smart City wireless networks for multiple applications, on one hand, and brings the long term expertise in large and complex carrier grade deployments with dozens of thousands of connections, which is required for the mission critical Smart Grid applications.
The future of bandwidth-hogging and low latency smart grid applications is quickly nearing and utilities need to determine next steps in their 4G infrastructure roll-out today. There is no one-size-fits-all when it comes to smart grid infrastructure given the wide variance in service territories and organizational priorities, but I believe a hybrid and optimized technology approach with unified network management will be necessary to achieve seamless smart grid service delivery.
To make the connected smart grid and an effective middle mile a reality, however, a "network of networks" with unified policies and management will be essential to preparing for the next generation of applications. We as an industry will need to carefully evaluate which technologies are capable of connecting the dots between homes, devices, the middle mile and last miles and vendors in the ecosystem. By carefully evaluating the options, utilities can determine the architectural approach and vendors that best fit specific needs for control, reliability and performance, security, proactive management capabilities and streamlined deployments.
VP Sales, Fullspectrum
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CHARLESTON, W.Va. — Roughly 100,000 residents may have suffered skin reactions, eye irritation, nausea or other ailments after exposure to MCHM following the January leak of the chemical into the Kanawha Valley's Elk River water supply, according to new estimates made public Tuesday.
The estimates are based on physician reports to the Kanawha-Charleston Health Department and a household survey conducted by a University of South Alabama environmental engineer who was later hired by Gov. Earl Ray Tomblin to investigate the impacts of the Freedom Industries leak.
Dr. Rahul Gupta, executive director of the Health Department, said his calculations put the number of people who experienced such symptoms at nearly 93,000. Using slightly different calculations, environmental engineer Andrew Whelton, who is a leader of Tomblin's West Virginia Testing Assessment Program, put the figure at just less than 109,000.
Their reviews — which have yet to undergo peer review or be published in a scientific journal — project far greater public health impacts on the region's residents than numbers previously released by the state Department of Health and Human Resources.
The DHHR previously had said that 26 people were admitted to area hospitals and 533 treated at released at those facilities for symptoms that could have been related to the leak. Those figures did not include any data for the day of the Jan. 9 leak or the day after. Also, the DHHR tracked only hospital treatments or admissions, and agency officials stopped counting after Jan. 23, records show.
"Those are probably gross underestimates of the true public health impacts," Gupta said. "It's the tip of the iceberg."
The new data from Gupta and Whelton are based on local physicians who reported patient information to the Health Department. Using what Gupta said is a standard procedure, the Health Department received ongoing reports from Jan. 9 to Feb. 9 from 10 physicians and extrapolated that sampling to account for all 1,600 medical providers in Kanawha and Putnam counties.
Also, Whelton had surveyed 16 households in early January. Those surveys provided useful data on how many residents had experienced common symptoms — skin reactions, eye irritation, nausea and headaches — but never sought medical treatment. Those data also were used to extrapolate further from the physician reports collected by the Health Department.
Gupta presented a summary of the findings as part of a Web-based seminar sponsored by National Association of County and City Health Officials. Whelton said that the new analysis has been submitted for peer review and possible publication in a scientific journal.
Reach Ken Ward Jr. at email@example.com or 304-348-1702.