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chownah wrote:I can't sit in half lotus any more as my knees won't handle it. If you are under the age of about 40 it is likely that if you approximate the half lotus and you sit every day twice a day then after awhile you will develop more knee flexibility and you can then do the half lotus and you might be able to after another while be able to do full lotus.....but it takes time....and for some people it just ain't going to happen.
As for instructions on how to do it....well...there really isn't much technique and I'm sure someone here can give better instruction than me.
cooran wrote:Hello face...,
Meditation posture workshop
Please consider all the links in the left-side margin:
with metta
mikenz66 wrote:I found this page useful too: http://www.mro.org/zmm/teachings/meditation.php
And see this thread for some more advice, including stretching from Ven Dhammanando
http://www.dhammawheel.com/viewtopic.ph ... 13&start=0
Jonttu wrote:I once read from a yoga book that in order to avoid permanently hurting the knees, it's important to kind of lock them first when getting into the lotus pose. This assures that the knees don't bend in abnormal ways, and that the flexibility comes from the hips rather than from the knees. I've found that using this technique with a good zafu, I can sit an hour in lotus, with minor pain occuring only in the last 10 minutes of the session.
daverupa wrote:The reason your knees hurt is because when your cross your legs without proper hip flexibility, the femur and tibia (which are normally aligned = parallel to each other) are tilted < like this, and the bones are pinching the menisci. This, over time, will ruin the knee(s).
The solution is to ensure that the two leg bones remain oriented appropriately. There are a number of solutions which are hard to describe solely with words; try reading this and see if it helps.
FaceaceRAWR wrote:mikenz66 wrote:I found this page useful too: http://www.mro.org/zmm/teachings/meditation.php
Oooo! I like that first pose. I've never seen it before, but it looks sooooo comfy!
Thank you, Mike!
mikenz66 wrote:Another thing. I don't think any position is very useful if it's only a mediation posture. If you're not comfortable to just sit like that for normal activities then it's probably a distraction to meditation. At home I spend quite a lot of time sitting in the Burmese position (on some cushions) with my computer, books, or papers on a coffee table. If I couldn't do that comfortably I'd meditate on a chair rather than start off with additional sources of discomfort.
David N. Snyder wrote:...Mindfulness can come in any position and the Satipatthana Sutta refers to the other 'positions' of standing, walking, and lying down. Ananda attained enlightenment in the lying down position, just as his head was about to hit the pillow.
FaceaceRAWR wrote:Anywho, I understand what you're saying, Mike, and that is definitely not the case. I'm just focusing on meditation poses because I want to practice new poses so I can cycle through them and not get all stiff from one or three.
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Clean-Plate Club
If you're a member of the "clean-plate club," here are a few tricks to ease your guilt and trim calories. When you "fill" you plate, start with smaller portions and don't go back for seconds. If the plate looks too sparse, add some leafy greens. Or, use a salad/luncheon plate rather than a dinner plate. Your plate will look full and you can clean it...without guilt.
© 2017 RDA Enthusiast Brands, LLC

subset: commoncrawl


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Office of Aboriginal Initiatives
WATERLOO: Grand Opening Aboriginal Community Garden, "Mino-Kummik"
Jun 21/13
Date: Jun 21/13
Time: 11:00 - 14:00
Location: Aboriginal Student Centre, 187 Albert St, Waterloo
Cost: FREE
The garden, located at the Aboriginal Student Centre at 187 Albert St., is named "Mino-kummik," which means "the good bountiful earth" in Ojibway. It was created through a partnership between Laurier's Office of Aboriginal Initiatives, Sustainability Office, Physical Resources, and REEP Green Solutions, a non-profit organization that promotes sustainable living. For more information click here
Join us for light refreshments and cultural demonstrations.
Please let us know that you can attend: RSVP click here
Contact: Melissa Ireland
Phone: n/a
View all WLU events


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Jethro Trujillo sat on a box top beneath a San Pedro bridge and leaned against a chain-link fence awaiting the 4:15 p.m. bus Monday to the Long Beach Rescue Mission's cold-weather shelter.
There, he would get a hot meal and a cot in a warm room for the night, avoiding the near-freezing overnight temperatures outside.
The record-breaking cold spell gripping the Los Angeles area left icy patches on local roads Monday morning, but warmer mornings are expected soon.
Amid sunny skies and strong winds, temperatures were forecast to remain low Tuesday, as they have been all winter, according to the National Weather Service.
A high-pressure system that is building will bring temperatures back to normal - about 10 degrees warmer - by the end of the week, weather service spokeswoman Bonnie Bartling said. "You're going to have sunny skies the whole time, then back-to-normal temperatures by Thursday and Friday."
Trujillo, a 68-year-old former mechanic, said he has been living on the streets since he lost everything in a divorce seven years ago and had worn out his welcome at the homes of family and friends. He said he goes to the winter shelter most nights because, in his words, "It's just survival, nobody likes it."
"This is no life, it's very bad," Trujillo said. At the shelter "you get dinner, breakfast - it's OK. Some people say jail is better and I tell them, `Go back to jail then."'
The cold-weather shelter opened on Dec. 1 and will close on March 15. About 140 cots are available at the Long Beach location, and they are filled most nights, said Francisco Maniego, a shelter assistant.
"It's kinda hard to sleep on a sidewalk on a cold night," Maniego said.
The Los Angeles Homeless Services Authority operates 20 cold-weather shelter sites across the county, with a total of 1,491 beds. The Long Beach site is the nearest refuge for residents of the South Bay and Harbor Area.
On Monday, a homeless man in his 50s was found dead on a sidewalk in downtown Los Angeles - on a morning when the 34-degree reading broke the previous record low of 36 degrees for Jan. 14 set in downtown L.A. in 2007. Authorities said the man may have been sleeping under blankets or a sleeping bag, and he appeared to die from natural causes.
Monday's high was 61 degrees at Los Angeles International Airport, where the low temperature was expected to dip to 42 degrees. Meteorologists expect that to increase steadily until Friday reaching a high of 71 degrees and a low of 50 at night. Temperatures will remain like that for several days, according to the weather service.
Damaging winds were forecast through Tuesday, with 60-mph gusts in the mountains, and gusts of 30 to 50 mph along the coast from the Hollywood Hills to Malibu.
Shari Weaver, who refers people to the Long Beach cold-weather shelter from Harbor Interfaith Services, said even people who usually avoid shelters are seeking refuge because it is so cold outside.
"What we're seeing right now is that some people who (wouldn't normally stay in a shelter) are coming in," Weaver said.
About a dozen people waited for the bus from San Pedro to the Long Beach shelter on Monday afternoon. Some carried light backpacks, and others had piles of luggage.
Joe Parra said he found out about the cold-weather shelter by calling the Los Angeles resource hotline at 211. He, too, said he had worn out his welcome at friends' homes.
"You can't be hitting people up every day," Parra said. "And you can't go back for a week or you become a pest."
Follow Sandy Mazza on Twitter at http://twitter.com/sandymazza


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Animals Vest Tops are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Animals Singlet for a special occasion, give a Animals Custom Tank Top as a present or need to represent with a funny Animals Vest Top during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Animals Singlet for you! Even if it turns out you can't find the right Animals Vest Top with the perfect design for your mother, father or children (or friends!); Idakoos offers all of its men's women's and children's Animals Vest Tops as Custom Animals Tank Tops. Personalize any Animals Custom Tank Top the way you want to ensure the perfect gift.
Showing 1 - 24 of 39176 Tank Top


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A port of the Project Darkstar demonstration game "Snowman" to the Red Dwarf community server.
Other Useful Business Software
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Doesn't build right. mvn clean package produces errors, sometimes only a single project builds, sometimes none, sometimes all of them. It's insane, and that type of insanity makes development impossible. Currently trying to pin down the problem, i believe it has to do with the download.java.net repo. I don't even think that repo is necessary, although not sure about that. Still trying to figure out what the problem is. Oh, it does work though. I got it to build by doing mvn package about 10x in a row, dropped the snowman jars in my RedDwarf server-dist, and fired it up and connected with the client. Just wish I could get past setting up my environment already and into some R&D.
yeah! finally :) thank you guys, very helpful!


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Art professor's work chosen for national association's exhibition
Muskingum College Assistant Professor of Art Ken McCollum has been selected to exhibit his works at the 40th annual National Council on Education for the Ceramic Arts (NCECA) conference in Portland, Oregon.
McCollum will exhibit 20 ceramic pieces for nearly 5,000 conference participants who will be in Portland from March 8-11. The pieces will then be on display at the Dorothy Steele Studio in Portland from March 10-31. An opening reception will be held at the studio on March 10. He was recommended for the honor by Joe Molinaro, professor of art at Eastern Kentucky University and Ted Vogel, professor of art at Portland State University.
McCollum joined the faculty at Muskingum College in 2000. He received his bachelor of fine arts degree from Phillips University, his master of arts degree from West Texas State University and his master of fine arts degree from Edinboro University of Pennsylvania. Last year, McCollum received the Award of Excellence for the Rosewood Art Centre's juried competition, Earth in Balance 2005.
The purpose of NCECA is to promote and improve the ceramic arts through education, research and creative practice. It offers programs, exhibitions and publications that are uniquely beneficial and rewarding to its membership of artists, educators, students, patrons, retailers and manufacturers.
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Apr 3, 2013 at 6:48 am
ST. PAUL, Minn. (AP) Minnesota state lawmakers are wading back into details of the Vikings stadium project as concerns build about the reliability of tax revenue from gambling to pay the state's share.
Tuesday saw the first meeting of a new House-Senate panel charged with oversight of Minnesota's publicly funded sports facilities. That includes the $975 million, downtown Minneapolis football stadium with an October groundbreaking and a hoped-for 2016 opening. But members of the panel raised concerns about shortfalls so far in tax revenue from an electronic gambling expansion.
Rep. Jim Davnie of Minneapolis says lawmakers need to know before they adjourn in May whether the funding setup needs major adjustments.
The chairwoman of the state's stadium authority says costs so far are being covered with a $50 million initial payment from the Vikings.
Temp: 53°F (12°C)
Dewpoint: 52
Wind: 8 N
Weather: Cloudy


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The surprise in Cierre Wood's decision on next season would have been if he'd decided to spend it at Notre Dame. Instead, the running back declared for the NFL draft on Monday.
ESPN first reported the senior running back's decision, which Irish Illustrated confirmed with mother Valerie Wood. Notre Dame announced Wood's decision later in the day.
Wood bypasses a fifth year of eligibility at Notre Dame, where he could have been the starting Irish running back next season.
"Having to make a decision like whether to stay in school or leave to pursue a lifelong dream of playing in the NFL is never simple," Wood said in a prepared statement released by the University. "I had to weigh many factors over the last month, but ultimately it came down to what I felt was the right decision that would most benefit my family. With that in mind, I'm leaving Notre Dame and am entering my name for this year's NFL draft.
"There are so many people I need to thank that have helped get me to this point. My teammates are friends I know I'll have the rest of my life. I'll miss hanging out with them in the locker room and around campus. They are a great group of guys and are poised for success next year.
"I also want to thank all of the coaches, specifically coach (Brian) Kelly and coach (Tony) Alford. Coach Kelly has the program heading in the right direction and I'm happy to know he'll remain our head coach in the future. Coach Alford has been so much more than a coach to me. He's been a mentor and a role model. He's helped turn me into the man I am today.
"Lastly, I want to thank the school, our fans and the extended Notre Dame family. The love and appreciation you've shown me in my four years can never be repaid. I'll always remember the ovation I received as I ran out of the tunnel on senior day and I can't thank you enough."
An NFL scout told Irish Illustrated during the season that Wood projected as a mid-round pick.
Wood's departure means Notre Dame must replace its top two running backs this off-season with Theo Riddick also departing. Riddick finished the season with 190 carries for 917 yards with Wood second at 114 carries for 742 yards. In the season's final two games against USC and Alabama, Wood carried just 12 times for 22 yards.
During the lead up to the BCS National Championship Game, Wood promised he'd announce a draft decision soon after the season finale, with the deadline for NFL draft decisions coming this week. Wood said the ability to be closer to his one-year old daughter Braelyn, currently living in Las Vegas, Nev., with the running back's mother, would be a factor.
Wood said he'd already made up his mind on next season before the bowl game and had received his draft feedback.
"That's for me to know and you to find out," Wood said. "You'll know if I make the decision or not.
"The only person I told really was my daughter. She can't really tell nobody."
Wood's departure opens the door for George Atkinson III to take over as Notre Dame's starting running back, with the spring competition coming from Will Mahone, Amir Carlisle and Cam McDaniel. Mahone and Carlisle both red-shirted this season while McDaniel had carries in just three games: Navy, Miami and Wake Forest.
Five-star running back Greg Bryant and four-star running back Tarean Folston, both Irish verbal commitments, are expected to enroll at Notre Dame next summer.
The production lost from Riddick and Wood represent 67.4 percent of Notre Dame's running yardage last season but less than half the team's rushing touchdowns. Atkinson and Everett Golson combined for 11 rushing touchdowns, with the quarterback leading the team with six.


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Raburn rebounding from 2012 with strong spring
SURPRISE, Ariz. -- Ryan Raburn, who signed to a Minor League contract with the Cleveland Indians over the offseason, is off to a hot start this spring.
Raburn hit .550 through nine games, with four home runs and 11 RBIs. Although the statistics do not count for much in Spring Training, Raburn's strong start is a positive sign for the Indians, as the 31-year-old utility player is coming off of a dismal 2012 season.
"He should feel confident," manager Terry Francona said. "He feels good about himself, and every time he goes up there, he puts the barrel on the ball. That's a good feeling as a hitter."
Raburn, who spent a large part of last season on the disabled list with a right quadriceps strain, played in 66 games with the Detroit Tigers and posted career lows in batting average (.171) and on-base percentage (.226).
Despite the struggles from a season ago, Raburn is a career .256 hitter with a simple swing that Francona believes will allow him to have success not only this Spring, but also during the regular season, regardless of his role.
"Whether he starts or comes in or plays half a game, he has that nice, short stroke working," Francona said. "I think his swing is really suited to do that. Everybody wants to play every day, but he has a nice short swing [that is suited for any role]."
William Boor is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil
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- Disclaimer
- How to Read a Study Record
|Preeclampsia Eclampsia HELLP Syndrome Pregnancy
|Drug: Vitamin C and E
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Prevention
|Official Title:
|RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil
- Incidence of preeclampsia
- Severity of preeclampsia
- Incidence of gestational hypertension or preeclampsia
- Frequency of abruptio placentae
- Incidence of preterm birth
- Incidence of small for gestational age
- Incidence of low birth weight infants
- Biomarker level correlation with preeclampsia
|Estimated Enrollment:
|Study Start Date:
|July 2003
|Study Completion Date:
|December 2006
The maternal, perinatal and neonatal morbidity and mortality rates for Brazil are five to ten-fold higher than those reported for upper income countries. In Sao Paulo, 22 percent of maternal deaths are attributable to hypertensive complications of pregnancy, which ranks as the number one cause of maternal death. Recent advances in the understanding of the pathophysiology of preeclampsia suggest the possibility of antioxidant therapy for the prevention of preeclampsia. The primary hypothesis is that the joint administration of the antioxidants vitamin C (1000 mg) and vitamin E (400 IU) will reduce the incidence of preeclampsia among chronically hypertensive pregnant patients and patients with a past history of preeclampsia/eclampsia. Secondary outcomes include severity of preeclampsia; incidence of gestational hypertension; incidence of premature rupture of the membranes; incidence of preterm birth; incidence of low birth weight infants; biomarker level correlation with preeclampsia.
Study sites are high-risk obstetrical clinics in the Brazilian cities of Recife, Botucatu, Campinas, and Porto Alegre. The sample size was based on an estimated risk of preeclampsia/eclampsia of 21-25% in the control group. The study hypothesizes a 40% absolute reduction of risk of preeclampsia; early treatment withdrawal of 3%; withdrawal of consent or loss to follow-up of 10%; calculated at a 0.05 significance level with 80% power. Seven hundred thirty-four obstetric patients with chronic hypertension or preeclampsia in the prior pregnancy presenting for care between 12 weeks and 19 weeks', 6 days gestation will be randomized to a double-blinded placebo controlled trial to receive a daily dose of either vitamin E (400 International Units) and vitamin C (1000 mg) or placebo from the time of enrollment to delivery. The use of MEMS caps enables researchers to accurately track compliance.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Gestational age between 12 weeks and 19 weeks, 6 days, inclusive
- Chronic hypertension
- History of preeclampsia/eclampsia
- Attendance at a participating hospital (Recife, Botucatu, Campinas and Porto Alegre, Brazil)
Exclusion Criteria:
- Planned delivery elsewhere.
- Multifetal gestation.
- Allergy to vitamin C or vitamin E.
- Requirement for aspirin or anticoagulant medication.
- Proteinuria ≥ 2+ on dipstick urine test; or proteinuria = 1+ on dipstick and ≥ 300 mg/24 hours.
- Pre-pregnancy diabetes mellitus.
- Known fetal anomaly incompatible with life.
- Prior participation in the study.
- Unwillingness to take the study medication.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00097110
|Federal University of Pernambuco
|Recife, Pernambuco, Brazil
|Principal Investigator:
|Joseph A. Spinnato, M.D.
|University of Cincinnati
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|NICHD Global Network for Women's and Children's Health
|ClinicalTrials.gov Identifier:
|NCT00097110 History of Changes
|Other Study ID Numbers:
U01HD040565 ( U.S. NIH Grant/Contract )
|Study First Received:
|November 17, 2004
|Last Updated:
|November 22, 2013
Keywords provided by NICHD Global Network for Women's and Children's Health:
Vitamin C
Vitamin E
Global Network
Preterm birth
Low birth weight infants
Maternal and child health
Women's health
Additional relevant MeSH terms:
HELLP Syndrome
Hypertension, Pregnancy-Induced
Pregnancy Complications
Ascorbic Acid
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents
ClinicalTrials.gov processed this record on September 25, 2017


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Kimberly-Clark: Putting the Big "M" in Marketing
October 21, 2011
Executive Summary
In this video clip, Tony Palmer, SVP & CMO, of the Kimberly-Clark Corporation talks about how his organization has a very clear marketing mantra: a brand is a promise and the product is the delivery of that promise. Organizations that deliver that promise better than their competition build brand equity. In order to achieve this, organizations have to know what they are doing from the beginning. Palmer urges leaders to spend more time examining their internal processes rather than focusing on consumers and brand only.
View video below.
"Kimberly-Clark: Putting the Big "M" in Marketing." Anthony J. Palmer, Senior Vice President, Chief Marketing Officer, Kimberly-Clark Corporation. ANA Masters of Marketing Annual Conference, 10/21/2011.
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Evolution Hoax
ON DECEMBER 21ST, THE AGE OF AQUARIUS COMES TO REIGN, THE REIGN OF THE SYSTEM OF HAZRAT MAHDI (AS). THAT IS TO SAY, THE WORLD WILL ENTER THAT SPIRITUAL ELECTROMAGNETIC REGION. THE ELECTROMAGNETIC REGION OF THE ANTI-CHRIST LIFTS OFF. IT IS REPLACED WITH THE ELECTROMAGNETIC REGION OF HAZRAT MAHDI (AS). You will start to feel it. You will see this. That is, you will feel it in your bodies, in your soul. You will feel it from midnight onwards. That is to say, the negative energy of the anti-Christ will come to an end. The spiritual realm of the Age of Aquarius, the system of Hazrat Mahdi (as) will reign throughout the world. Allah will manifest Himself with His name, "Hadi". There is an attribute of Allah that misguides them. It will no longer manifest itself. Instead of it, the name "Hadi" will reign, insha'Allah.
2013-01-31 12:24:17


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All Current Offers
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The developers of our award-winning Starry Night® software are pleased to announce the release of version 6.3, which is available now for purchase. Starry Night Pro Version 6.3 Astronomy Software is the most robust version yet, with performance-enhancing features such as new planets and their moons and five new horizon panoramas.
Starry Night® has never been better. So don't delay, get the new version 6.3 today!
Increase your in-the-field observing success with Starry Night Pro version 6.3. Use the Events Finder to choose targets, or make your own Observing List for a specific night or for specific objects of interest. Print out three-view starhopping charts customized to your equipment that effortlessly guide you to challenging objects. With extensive data sets, advanced telescope control, and comprehensive observational tools, Starry Night Pro is a powerful program designed for the serious astronomer. Transform your computer into a sophisticated virtual observatory.
New Version 6.3 Features:
Other Features:
Starry Night Pro version 6.3 includes:
QuickGuide to Starry Night
Also Improved in Starry Night Version 6.3:
What happens if I only have OpenGL 1.4 and not OpenGL 2.0? Will Starry Night version 6.3 run?
In Starry Night version 6.3, the graphics default settings are not any more graphics-intensive than version 5. The 2 things that are new and may not be supported are:
The ONLY new features which require a better video card than Version 5 are the two eye-candy features listed above. Overall, the other graphics in the application will not be affected if you only have an OpenGL 1.4 card.
System Requirements
To run Starry Night Pro version 6.3 you need:
If you own an earlier version of Starry Night Pro 6, click here to update to Starry Night Pro Version 6.3.
Boxed software which has been opened cannot be returned except for an exact exchange to replace defective software.
Orders received by 1pm Eastern Standard Time for in-stock item the same business day. Order received after noon will ship the next business day. When an item is not in-stock we will ship it as soon as it becomes available. Typically in-stock items will ship first and backordered items will follow as soon as they are available. You have the option in check out to request that your order ship complete, if you'd prefer.
This product is available to ship Standard delivery within the 50 US states, APO/DPO/FPO addresses and US territories/protectorates. Delivery is not available to Canada.
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Online or in your mailbox. Check out our colorful catalog, filled with hundreds of quality products.
Please send me email about sales, new products, and astronomy.
Since 1975 Orion Telescopes & Binoculars has been offering telescopes for sale direct to customers, with an unswerving commitment to best quality products, value and unmatched customer care. Our 100% satisfaction guarantee says it all.
Orion offers telescopes for every level: Beginner, Intermediate, Advanced, and Expert. From our entry level beginner telescopes for amateur astronomers to our Dobsonian telescopes to our most advanced Cassegrain telescopes and accessories, you can find the best telescope for you. Because we sell direct, we can offer you tremendous value at a great price. Not sure how to choose a telescope? Orion's Telescope Buyer's Guide is a great place to start.
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Travel in ultimate comfort with the aid of these custom travel accessories that include a neck pillow, eye mask, ear plugs and socks in an imprinted pouch.
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Office Products North America
|Avery Dennison Contact:
|Fran Youssef
|(714) 674-8335
Brea, Calif. – October 27, 2009 – Avery Dennison Office Products, a business unit of Avery Dennison Corporation (http://www.avery.com), is making do-it-yourself Halloween projects fun, creative and budget friendly with Avery Templates, Fabric Transfers, Window Decals and more.
"Halloween should be a little hair-raising, but the price of decorating shouldn't be," says Brenda Dillon. "Avery products make it easy to come up with fun Halloween ideas that the whole family - or even your classroom or office - will enjoy. From scary pumpkin stencils and carving templates to personalized trick or treat bags and everything in between - you'll find a Halloween project that's fun and easy on your wallet."
- Avery Halloween Templates. Just choose a pumpkin template or a host of other haunting images and then customize and print your choice of designs with an ink jet or laser printer.
- Avery Fabric Transfers. Using cloth bags or pillowcases with these fabric transfers, it's easy to make great trick or treat bags for collecting all that candy.
- Avery Window Decals. Print some spooky decals to add some Halloween style to any windows. The templates can even be personalized to create customized Halloween messages.
- Avery Labels. Label treats for Halloween parties at school, work or home quickly and easily. The labels can also be used to create Halloween address labels for party invitations and much more.
For more Halloween ideas, projects and free templates from Avery, visit http://www.avery.com/avery/en_us/Projects-&-Ideas/Ideas-for-Home/Holidays.
About Avery Dennison Office Products
Avery Dennison Office Products group markets products under the well-known Avery brand name and is one of the world's leading manufacturers of self-adhesive labels for laser and ink jet printers, labeling software, binders, sheet protectors, index and tab dividers and other office-, home- and school-related supplies. Avery Dennison Office Products, a business unit of Avery Dennison Corporation, is based in Brea, California.
For more information about Avery-brand products, consumers can visit the Avery Dennison Worldwide Office Products Web site at www.avery.com or call the Avery Dennison Consumer Service Center at 1-800-GO-AVERY (1-800-462-8379). Avery and all other Avery brands and product names are trademarks of Avery Dennison Corporation.
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A CAR went into a ditch and a second overturned when they collided on the A64 just east of Malton this evening.
Other cars stopped to help the five people who were in the two vehicles.
The road was briefly blocked, but police are now letting traffic through under their control and hope to have the road fully open later this evening.
No-one was seriously injured.


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'He's still No. 3 on the Sabres depth chart as the only goalie under contract behind Ryan Miller and Martin Biron. "He's right there on the doorstep and I think he's had a long conversation with Jimmy (Corsi) about that," Cunneyworth said. "The way he fills the net is very Miller and Biron-like. We point to the level of compete that Ryan Miller has, where he never gives up on a shot, and that's where Michael Leighton has to go."'
You are here: Home / SabresBeat / Leighton wants to show Sabres his future is in NHL


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Monday June 10, 2013 2:51 pm
Live coverage of Apple's WWDC 2013 keynote!
Posted by Andru Edwards - Categories: Apple, Features
It's time! Apple is set to take the stage to kick off its annual Worldwide Developers Conference this morning, which means we will be getting a look at iOS 7, OS X 10.9, iCloud updates, the new Apple streaming music service, and more. It is a big morning that is gonna be packed with new hotness (and, hey, the Microsoft Xbox One E3 event is happening at the same time!), so head past the break for all the news coming out of WWDC 2013 as it happens!
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- apple, sidefeatured, wwdc, wwdc 2013
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The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Genetic Polymorphism
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications in Patients Undergoing Invasive Procedures in the Hybrid Cardiac Catheterization/Cardiac Surgery Suite
- genetic determination of bleeding verses thrombotic risk factors in patients undergoing cardiovascular procedures
Biospecimen Retention: Samples With DNA
|Estimated Enrollment:
|Study Start Date:
|September 2006
|Study Completion Date:
|February 2010
|Primary Completion Date:
|February 2010 (Final data collection date for primary outcome measure)
The aim of this study is to test the association of DNA polymorphisms linked to the level of αβ1 integrin expression on platelets with clinical outcome in terms of bleeding or thrombotic complications. The association of polymorphisms in other genes such as GPVI, PAR-1, and COX-2, as well as PLA ½ status, will also be examined and considered in the context of other factors such as medications including IIb/IIIa inhibitors, anticoagulants, type of procedure, obesity smoking status, etc.
Lower levels of platelet surface expression of the α2β1 integrin are associated with an increased risk of bleeding complications following hybrid procedures, especially when the low level of integrin expression is associated with other risk factors that may exacerbate bleeding such as vigorous anti-coagulation, aggressive anti-platelet therapy and other genetic risk factors that contribute to a hemorrhagic phenotype. Conversely, higher level expression of the α2β1 integrin is likely associated with a greater tendency to thrombotic complication that is again modified by other coexisting risk factors.
|Ages Eligible for Study:
|18 Years to 70 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Inclusion Criteria:
- Patients will be recruited to the study who are to undergo elective hybrid procedures [percutaneous coronary intervention (PCI) followed by minimally invasive coronary artery bypass graft (CABG) surgery or valve surgery].
- Both male and females will be enrolled in this study.
- The age of the population is 18-70 years old.
- No one ethnic group or gender will be targeted or excluded.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00603148
|United States, Tennessee
|Vanderbilt University Medical Center
|Nashville, Tennessee, United States, 37232
|Principal Investigator:
|Samuel A. Santoro, MD, PhD
|Vanderbilt University
|Responsible Party:
|Samuel A. Santoro, Professor and Chair, Pathology, Microbiology & Immunology, Vanderbilt University
|ClinicalTrials.gov Identifier:
|NCT00603148 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 17, 2007
|Last Updated:
|December 16, 2013
Keywords provided by Samuel A. Santoro, Vanderbilt University:
Genetic Polymorphism
Integrin alpha2beta1
ClinicalTrials.gov processed this record on September 21, 2017


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A TEENAGER was left needing surgery after being shot in the arm with an air gun.
The 13-year-old suffered the injury at Lions Gorge in Chafford Hundred at around 6.15pm yesterday.
Two 24-year-old men, one from Stanford-le-Hope and one who did not give an address, were arrested on suspicion of assault following the incident.
The youngster, who lives in the area, ended up with a pellet in his arm and will require surgery.
Dc Adam Stallard, of Grays CID, said: "The area is a popular fishing spot and young people do like to hang around there. We would like to speak to anyone who may have seen what happened or who has any further information."
Anyone that can help is asked to call Grays CID on Essex Police 101 or Crimestoppers anonymously on 0800 555 111.


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By Tom Withers | Associated Press
CLEVELAND -- Brian Hoyer is coming home to play for the first team he ever loved.
Hoyer, who grew up rooting for the Browns and starred at Cleveland's St. Ignatius High School, signed a two-year contract on Friday, adding veteran experience to a troublesome position.
Hoyer agreed to the deal Thursday but had to pass a physical before it could be finalized. Hoyer was released earlier this week by the Arizona Cardinals.
"Brian brings experience and a solid reputation to our squad," Browns coach Rob Chudzinski said in a release. "We are looking forward to getting him out on the field."
Hoyer will compete for a backup job with the Browns, who expect Brandon Weeden to beat out Jason Campbell to be the starter. Hoyer will get his chance to work his way up the depth chart, but he has a long climb.
Hoyer was signed by New England as an undrafted free agent in 2009 and spent three seasons backing up Tom Brady. He was briefly with Pittsburgh before he was claimed off waivers by the Cardinals. He appeared in Arizona's final two games last season, completing 30 of 53 passes for 330 yards with one touchdown and two interceptions.
Hoyer's arrival likely will impact third-stringer Thaddeus Lewis, who started Cleveland's season finale against Pittsburgh after Weeden and Colt McCoy got hurt.
Hoyer will be on the field next week as the Browns continue their first organized team activities (OTAs) under Chudzinski.


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BMX Biking : How to Build BMX Dirt Jumps
In order to build a BMX dirt jump, start by making sure there is plenty of room between jumps. Find out how to start building a dirt jump by beginning with the takeoff with help from a BMX bike racer in this free video on building BMX dirt jumps. Expert: Shane Jackson Contact: www.evolutionbikeco.com Bio: Shane Jackson has 20 years of experience racing BMX bikes. Filmmaker: Michael Burton
Video Rating: 4 / 5


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Vaccine Therapy in Treating Patients With Stage III-IV or Recurrent Ovarian Cancer
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- Tabular View
- No Study Results Posted
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- How to Read a Study Record
|Stage III Ovarian Epithelial Cancer Stage III Ovarian Germ Cell Tumor Stage IV Ovarian Epithelial Cancer Stage IV Ovarian Germ Cell Tumor
|Biological: pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine Other: laboratory biomarker analysis
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase I Trial of the Safety and Immunogenicity of a DNA Plasmid Based Vaccine Encoding the Amino Acids 1-163 of Insulin-Like Growth Factor Binding Protein-2 (IGFBP-2) in Patients With Advanced Ovarian Cancer
- Safety as assessed per Cancer Therapy Evaluation Program (CTEP) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: Up to 16 months ]Demographic and background characteristics obtained at enrollment will be listed and summarized. The type and grade of toxicities noted during the immunization regimen will be summarized. All adverse events noted by the investigator will be tabulated according to the affected body system. Descriptive statistics will be used to summarize changes from baseline in clinical laboratory parameters.
- Immunogenicity, via cellular immune response and humoral immune response, as assessed by the generation of IGFBP-2 specific T cells and IgG antibodies [ Time Frame: Up to 16 months ]Cellular immune response will be defined by the magnitude of the Th1 antigen specific immune response using IFN-gamma enzyme-linked immunosorbent spot (ELISPOT). Humoral immune response will be measured by enzyme-linked immunosorbent assay (ELISA) and serum antibody avidity for IGFBP-2 using ELISA to determine an avidity index (AI) before and after vaccination. Spearman's correlation coefficient will be used to estimate the correlation between two continuous measures.
- Epitope spreading with the generation of an IGFBP-2 Th1 immune response [ Time Frame: Up to 16 months ]Peripheral blood mononuclear cells (PBMC) will be assessed by ELISPOT for immunity to a panel of immunogenic ovarian cancer related proteins: topoisomerase II-alpha (a), p53, IGF-IR, FASCIN-1, and MMP-7. Epitope spreading will have been considered to occur if new immune responses are generated to any of these antigens during the course of the study. In addition, epitope spreading and T regulatory cells will be defined as present or absent, and the probability of each will be estimated as a simple proportion as above with toxicity.
- Levels of regulatory T- cells (Tregs) over the course of immunization to detect modulation of Tregs with vaccination [ Time Frame: Up to 16 months ]Assessed by flow cytometry of PBMC. In addition, epitope spreading and T regulatory cells will be defined as present or absent, and the probability of each will be estimated as a simple proportion as above with toxicity.
- Disease-free survival [ Time Frame: Up to 5 years ]A questionnaire will be sent to the patient's primary oncologist requesting laboratory evaluation of toxicity, CA-125, and the patient's disease free and overall survival status.
- Overall survival [ Time Frame: Up to 5 years ]A questionnaire will be sent to the patient's primary oncologist requesting laboratory evaluation of toxicity, CA-125, and the patient's disease free and overall survival status
|Estimated Enrollment:
|Actual Study Start Date:
|March 6, 2012
|Primary Completion Date:
|January 9, 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment (pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine)
Patients receive pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine ID monthly for 3 months.
Biological: pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine
Given IDOther: laboratory biomarker analysis
Correlative studies
Detailed Description:
I. To determine the safety of an insulin like growth factor binding protein 2 (IGFBP-2) Th polyepitope plasmid based vaccine in patients with advanced stage or recurrent ovarian cancer.
I. To determine the immunogenicity of IGFBP-2 Th polyepitope plasmid based vaccine in patients with advanced stage or recurrent ovarian cancer.
II. To determine whether intermolecular epitope spreading occurs with the generation of an IGFBP-2 specific Th1 immune response.
III. To determine whether IGFBP-2 vaccination modulates T regulatory cells.
Patients receive pUMVC3-hIGFBP-2 multi-epitope plasmid DNA vaccine intradermally (ID) monthly for 3 months.
After completion of study treatment, patients are followed up at 1, 3, 6, and 12 months, and then every 6 months for 5 years.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with advanced stage (III/IV) or recurrent ovarian cancer who have been treated to complete remission with standard therapies including primary debulking surgery
- Cancer antigen 125 (CA-125) level within normal limits for the testing laboratory must be documented 90 days prior to enrollment when the assessment of CA-125 is applicable
- Patients must be at least 28 days post cytotoxic chemotherapy, and/or monoclonal antibody therapy, prior to enrollment
- Patients must be at least 28 days post systemic steroids prior to enrollment
- Patients must have Eastern Cooperative Oncology Group (ECOG) Performance Status Score of =< 2
- Patients must have recovered from major infections and/or surgical procedures, and in the opinion of the investigator, not have any significant active concurrent medical illnesses precluding protocol treatment
- Estimated life expectancy of more than 6 months
- White Blood Cell (WBC) >= 3000/mm^3
- Hemoglobin (Hgb) >= 10 mg/dl
- Hematocrit (Hct) >= 28%
- Serum creatinine =< 2.0 mg/dl or creatinine clearance > 60 ml/min
- Total bilirubin =< 2.5 mg/dl
- Aspartate aminotransferase (AST)/serum glutamic oxaloacetic transaminase (SGOT) =< 3 times upper limit of normal (ULN)
- Blood glucose < 1.5 ULN
Exclusion Criteria:
- Patients with any of the following cardiac conditions: symptomatic restrictive cardiomyopathy; unstable angina within 4 months prior to enrollment; New York Heart Association functional class III-IV heart failure on active treatment; symptomatic pericardial effusion
- Uncontrolled diabetes
- Patients with any contraindication to receiving sargramostim (rhuGM-CSF) based products
- Ovarian cancer of a low malignant potential phenotype or clear cell histology
- Patients with any clinically significant autoimmune disease uncontrolled with treatment
- Patients who are currently receiving an anti-IGF-IR monoclonal antibody as part of their treatment regimen
- Patients who are simultaneously enrolled in any other treatment study
- All subjects able to bear children
Please refer to this study by its ClinicalTrials.gov identifier: NCT01322802
|United States, Washington
|Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Principal Investigator:
|Mary Disis
|Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
|Responsible Party:
|University of Washington
|ClinicalTrials.gov Identifier:
|NCT01322802 History of Changes
|Other Study ID Numbers:
NCI-2011-00099 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
7396 ( Other Identifier: Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium )
P30CA015704 ( U.S. NIH Grant/Contract )
|Study First Received:
|March 7, 2011
|Last Updated:
|April 3, 2017
Keywords provided by University of Washington:
Ovarian Cancer
Stage III
Stage IV
Additional relevant MeSH terms:
Ovarian Neoplasms
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Neoplasms by Histologic Type
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 19, 2017


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USF's first recruiting commitments for 2012 are starting to come in, and Rayshawn Jenkins, a 6-foot-1, 190-pound quarterback and safety from St. Petersburg Admiral Farragut, said he accepted a scholarship offer on Wednesday to play for the Bulls.
Jenkins, a state champion last year in the 110-meter hurdles and runner-up in the 300 hurdles, said he'll play free safety at USF, though he'll continue to play quarterback and even occasionally receiver at Farragut. He said USF offered him two weeks ago, and he chose the Bulls on Wednesday over interest from Florida State, Georgia and Kansas.
"USF is a rising program, and I wanted to be a part of that," Jenkins said. "It's close to home."
Jenkins was recruited to USF by assistant Vernon Hargreaves, and he'll make much the same transition as rising sophomore JaQuez Jenkins, who was a high school quarterback at Lakewood but has made his mark at USF at safety. Jenkins knows JaQuez (no relation) and safety Jerrell Young, as well as defensive end Julius Forte. Asked for his strengths on the field, Jenkins cited his "leadership and hard work." He said he would like to compete in track while at USF as well.
According to 247sports.com's Josh Newberg, USF picked up a second commitment on Thursday from Ryan Brown, a 6-foot-5, 240-pound defensive end from Marrero (La.) Archbishop Shaw.


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The New School
Writing for Children Forum: Rachel Cohn
Rachel Cohn is the author of many young adult novels, including the Gingerbread series, You Know Where to Find Me, and Very LeFreak. She has co-authored three collaborations with David Levithan: Dash & Lily's Book of Dares, Naomi & Ely's No Kiss List, and Nick & Norah's Infinite Playlist, which was turned into a movie starring Michael Cera and Kat Dennings. Her most recent book, Beta, is the first in a 4-book Young Adult sci-fi series about a teenage girl who is a clone.
Moderated by Patricia McCormick, author most recently of New Fall Down, nominated for a 2012 National Book Award in Young People's Literature.
Sponsored by the School of Writing.
Alvin Johnson/J. M. Kaplan Hall, 66 West 12th Street, room 510
$5; free to all students and New School faculty, staff, and alumni with ID at the door or at the Box Office.
Single event purchases can be made online at any time at the New School Box Office. Series and discounted tickets must still be made in person or over the phone at The New School Box Office at 66 West 12th Street, main floor, Monday-Thursday 4:00 to 7:00 p.m., and Friday 3:00 to 6:00 p.m. The box office opens the first day of classes and closes after the last paid event of each semester. Reservations and inquiries can be made by emailing email@example.com or calling 212.229.5488.For events scheduled during the summer term, the box office will open one hour before each event.
Email Updates
Browse Events by School


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Electronic cigarettes grow in popularity, effects unknownPosted: Updated:
Have you been noticing people puffing away inside restaurants and bars? You may be outraged, thinking they're smoking cigarettes near your table, but you wouldn't entirely be correct. Electronic cigarettes are quickly growing in popularity.
E-cigarette lovers said the main difference between a normal cigarette and an electronic one is that the e-cigarette emits water vapor, not smoke. But we wanted to know - does that make it safe?
"I don't want to die of cancer," said Alexis Fox, who was buying her first electronic cigarette at Synergy Vapor Labs in Tempe. The owner of the store, Lee Phemister, said that's the No. 1 reason people walk in to buy his products.
"I guess the habit of putting something in your mouth and exhaling something, it tricks your mind and body into thinking you're still smoking," Phemister said.
Isn't he, though? After all, Phemister is still inhaling nicotine. But so-called e-cigarettes work differently. The battery heats a coil inside the electronic cigarette, which turns a flavoring agent with nicotine into a vapor.
"Pretty much everyone I know uses it," Fox said. And a recent CDC study would support that. It said not only do more adults know about the electronic cigarettes, but more people are also using them. And that might not be a good thing.
"Unfortunately we do not have much data available regarding this product. It is not regulated by the FDA," said Dr. Syed Shahryay, a pulmonologist at St. Luke's Medical Center. He said on the surface, electronic cigarettes appear to be a safer alternative, but he said not smoking anything is always best.
"There may be a potential that it may help people who are trying to quit smoking, but we do not have a lot of data in this regards to support this," he said.
Phemister said while he agrees more research needs to be done, he's happy he said goodbye to his pack-and-a-half-a-day habit.
"The fact of the matter is we're human and we have vices," Phemister said.
You may wonder whether people can still smoke the e-cigarettes indoors. Phemister said it's up to each business since the laws don't address electronic cigarettes yet.
Copyright 2013 CBS 5 (KPHO Broadcasting Corporation). All rights reserved.


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IT COVERS 71 PERCENT of our Earth's surface, we couldn't live without it, and it's a lot of fun to play in.
Water — where would we be without it?
The IJ asked readers to share their thoughts, poetically, on water; here's what they had to say.
Our next big holiday is approaching — Labor Day, when we pay tribute to what we all accomplish at work. So, it seems a good time to focus on work for August's Haiku Challenge.
As usual, please send just one haiku, sticking to the traditional 5-7-5 Japanese form, along with your name and town (submissions are disqualified if there's no Marin town listed) — by 5 p.m. Aug. 9 to firstname.lastname@example.com. Please put "Work Haiku" in the subject line. We'll run them in the Aug. 27 Plus section and online.
I will drink water
instead of a martini
To feel virtuous
— Mary Dusenbery, Tiburon
Do pale jelly fish
Leave sea seeking summer sand
To get a bronze tan?
— Victoria Rubini, San Rafael
Leaning back, head still
Breaking through the liquid glass
A new life begins.
— Shannon Waterford, San Rafael
High tide fills the creek
Mallards and egrets abound.
Then the tide goes out.
— Elaine Johnson, Greenbrae
Wasted and defiled
Yet precious and essential
Water wars ahead.
— Will Harrison, Greenbrae
Whether tears of woe
Or tears from heavy laughter,
Water fuels my life.
— Richard Park, Novato
Water, blood of life
No water, no grass or grains
No eyes to see void
— Inta Abele, Novato
Morning awakens
Mount Tamalpais beckons
We lace up our boots
— Bill Mayers, San Rafael
Traverse deep marine
layers of the subconscious
Hot tub therapy
— Steven Wright, Sausalito
Water equals life
Water more precious than gold
Water will be rare
— Jim Crumpler, Novato
Water in my veins
Cleanse my spirit and my soul
River of my heart
— Allison Kegley, San Rafael
Since the '70s
I take a Navy shower
Wet, off, soap, rinse, done.
— Skip Corsini, San Rafael
Water is life's blood.
Dry skies and salty seas rise.
Bad air, bad water.
— Megan Clark, San Rafael
Hand on the tiller
my bro races a Star boat
we round a buoy
— Jean Rhodes, Mill Valley
Days are oh so hot!
Air is damp, can't even breathe
Drink cold water — aah!
— Shirley Nye, Novato
Drip, drip on my tongue
quench my thirst, oh, summer rain
each drop by sweet drop
— Janice Kohnhorst, San Rafael
Bugs, birds, rodents, deer
Our invasion, their hillside
Shall we coexist?
— Pam Sweeney, San Rafael
Water from on high,
Rushing, falling spectacle
Niagara calls
— Elizabeth Yungul, Mill Valley
Rain, streams, wells, oceans
Support my pleasure, my life
Most precious resource
— Mary Van Voorhees, Greenbrae
Wind over water
Wingsailed catamarans soar
All race for the Cup.
— Julie Detro, Novato
Foundation floats on water.
Leaks show faults to cure.
— Bob Dougherty, Tiburon
Springs, streams, rivers, lakes
Water's essential to life;
Respect, conserve it
— Grace Terrell, Novato
A dripping rain day
Cool after hot June solstice
And Mount Tam Jam
— Kathie Dalessandri, Point Reyes Station
Life-giving nectar
Priceless: fresh, clean, sweet water
Think: conservation
— Joy Ruppersburg, San Rafael
Water everywhere
So we take it for granted;
We are running short
— Val Onick, Greenbrae
Vicki Larson can be reached at firstname.lastname@example.com; follow her on Twitter at @OMGchronicles, fan her on Facebook at Vicki-Larson-OMG-Chronicles


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A MAN has appeared before magistrates in Cornwall charged with the murder of a former Rossendale man.
Kevin Cooper, 33, from Redruth, was accused of killing David Alderson, who is originally from Rawtenstall, and whose body was found in mine works on January 18.
Cooper, who had been arrested in Newbury, Berkshire, was remanded in custody at the Truro hearing, to appear before the town's crown court on March 4.
Mr Alderson, a former driving instructor, moved to Cornwall from East Lancashire around 30 years ago.
He was last seen living his home in the Old Hall area of Falmouth on January 17.


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The contribution of John Innes Centre scientists to improving one of the world major crops highlights the impact of publicly-funded fundamental research decades ago on people's lives today – and shows the benefit of today's research for future generations.
"Wheat genetics research in the UK", published by the Biotechnology and Biological Sciences Research Council (BBSRC), describes a shift in overall wheat production in the UK of 2.5 tonnes per hectare in 1940 to more than 8 tonnes per hectare today.
The report explains that JIC scientists' understanding and application of the complex genetics of wheat, the subsequent development of new varieties and the introduction of better farming practices has either directly or indirectly led to most of the major advances in production in the UK.
Wheat makes up 20% of the calories consumed by people across the world – with predicted rise in population from 6billion people today to 9billion by 2050, changing land use and adaptation to climate change, increasing wheat yields are seen as key areas by both the John Innes Centre and BBSRC which provides strategic funding to the institute.
The report describes BBSRC-funded research carried out by JIC senior scientist Professor Graham Moore (pictured) on 'synteny' – being able to identify a gene in an organism with a large genome such as wheat by first locating it in an organism with a smaller one, like rice. As the rice genome is smaller than that of wheat, it is quicker to identify a gene in rice and look for the same gene in wheat than it is to first examine the larger wheat genome.
Prof Moore demonstrated synteny between rice and wheat 20 years ago, using the early genetic maps of wheat developed by JIC colleague Professor Mike Gale and Japanese collaborators working on rice.
A decade earlier, Professor Dick Flavell, of the Plant Breeding Institute – which merged with the John Innes Institute and the Nitrogen Fixation Laboratory to form the John Innes Centre – became the first researcher anywhere in the world to clone plant DNA, which happened to be wheat DNA.
Thanks to Prof Moore's research, synteny has been at the heart of wheat breeding and genetics research around the world – the identification of rust resistance in wheat, the discovery of wheat genes for high grain protein and the identification of wheat genes which determine a plant's ability to flower in spring were all made possible due to synteny.
Prof Moore also used the concept of synteny to study an important gene called Ph1, which regulates reproduction in plants. Ph1 prevents wild wheat varieties breeding with elite wheats, making it difficult for breeders to introduce traits such as disease resistance to new elite lines. Research on this trait started in the 1950s, when PBI scientist Sir Ralph Riley recognised that Ph1 was preventing the crosses. Sir Ralph went on to use his knowledge to introduce resistance in wheat to the Yellow Rust fungus, which is a major problem for growers.
In a BBSRC-funded study which started in the 1980s, Prof Moore and colleagues found genetic sequences next to the Ph1 gene in a grass called Brachypodium, which has a small genome, and used synteny to find the same sequence in wheat. Building on this knowledge, they showed that okadaic acid could mimic the effect of deleting Ph1, allowing the cross of wild and elite wheats and transfer of important traits. Based on their work, BBSRC funded a wheat pre-breeding programme in 2012 for further advances using Prof Moore's work.
Researchers at PBI and, later, the John Innes Centre also identified the Rht1 gene responsible for the so-called Green Revolution of the 1940s to 1970s. The expression of the Rht1 gene is responsible for reducing the height of wheat crops, meaning that the plant's energy is used for growing wheat grain rather than stalk resulting in a higher grain yield.
PBI breeders used conventional breeding in the 1960s to develop new wheat lines showing the Rht characteristic which are now in use in UK wheat production and worth £75m to the economy each year.
Further work on the Rht1 gene was led by JIC scientist Professor Nick Harberd in the 1990s – he and colleagues successfully located an equivalent gene in the model grass species Arabidopsis and in maize. They discovered how the natural mutation in the gene had led to the appearance of the short stalks, and also identified nearby 'marker' genes which are easier for breeders to select for plants with the Rht1 trait.
John Innes Centre scientists have also been researching the genetics of flowering time, and how plants respond to environmental cues like day length. The research has taken place over the last 30 years, initially by Professor Colin Law and colleagues at PBI, leading on to studies by JIC scientist Dr David Laurie. Their understanding means plant breeders can control flowering time and develop new varieties which can adapt to climate change.
The bread-making qualities of wheat have also been the subject of studies at PBI and at JIC. Good bread-making dough depends on the two component proteins of gluten – gliadins and glutenins. Before the Second World War, most of the UK's bread-making wheat was imported from the USA and Canada, where varieties were rich in gluten proteins. Research and the development of UK wheat with optimal gluten levels has led to 4.5m tonnes of bread wheat grown in the UK today. This was made possible due to the work of PBI scientists Dr Peter Payne, Professor Colin Law and Professor Dick Flavell in the 1970s and 1980s, leading to work at Rothamsted Research.
As can be seen, investment in fundamental research has led to wide-ranging benefits to the UK economy and UK society. Research takes time, with many of the developments taking place over at least 30 years. The John Innes Centre continues to receive funding from the BBSRC which enables this strategic research to take place.
Today, scientists at JIC continue to understand the genetics of wheat and are working towards future developments. For example, Professor John Snape developed approaches for genetically dissecting more complex traits in wheat, which are controlled by multiple genes. Prof Snape began applying these approaches to dissect the genetics of yield in wheat. Dr Simon Griffiths and Dr Cristobal Uauy (pictured) are exploiting and extending these developments, so that in the future we should have an understanding of the control of yield in wheat. This will be important given the predicted increase in the human population.


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La Mirada Theater Presents NOISES OFF, Opens 9/23
LA MIRADA THEATRE FOR THE PERFORMING ARTS & MC COY RIGBY ENTERTAINMENT will open their 2011-2012 season with one of the funniest comedies of all time, NOISES OFF written by Michael Frayn and directed by Richard Seyd. NOISES OFF will open on Friday, September 23, 2011 (with a press opening on Saturday, September 24) and run through Sunday, October 16, 2011 at La Mirada Theatre for the Performing Arts, 14900 La Mirada Blvd in La Mirada.
One of the most inspired farces ever written presents a manic menagerie of itinerant actors rehearsing a flop. Out-of-control egos, memory loss and passionate affairs turn every performance into a high-risk adventure. Progressing from flubbed lines and missed cues in rehearsal to mounting friction between cast members in the final performance, Noises Off is a comic triumph of slamming doors, falling trousers and flying sardines!
Richard Seyd (Director) is currently directing a rock musical called The Twelve. Most recently directed By The Waters Of Babylon a new play by Robert Schenkkan the Pulitzer Prize winning playwright of The Kentucky Cycle at the Geffen Playhouse and previously at Seattle Rep. He has directed productions of Noises Off at San Jose Rep, Pasadena Playhouse, Seattle Rep and commercially at the Marines Memorial Theatre in San Francisco, and a highly successful production of A Reckoning with Jonathon Pryce at the Soho Theatre in London's West End. Previously he directed A Feast of Fools (with Geoff Hoyle) at the Marines Memorial Theatre and at LaJolla Playhouse. Other regional theatre productions include: Berkeley Repertory Theatre, Dinner with Friends (Bay Area Critics Circle Award); The Beauty Queen Of Leenane (Bay Area Critics Circle Award), Collected Stories (Garland Award from BackStage West); Who's Afraid Of Virginia Woolf and A View From The Bridge. He has also received Drama-Logue, BackStage West and Bay Area Critics Circle Awards for his direction of Cloud Nine, About Face, Noises Off, Oleanna, A View From The Bridge, Rosencrantz And Guildenstern Are Dead, and A Streetcar Named Desire.
From 1992 - 1997 he served as Associate Artistic Director of the American Conservatory Theater in San Francisco. For ACT he directed The Learned Ladies, Dario Fo's The Pope And The Witch, Pygmalion, Mrs. Warren's Profession, Oleanna, Rosencrantz And Guildenstern Are Dead, Othello, The Matchmaker, and A Streetcar Named Desire.
In the 1980's Richard was Associate Producing Director of the Eureka Theatre, and directed many productions for the company including Cloud Nine (which ran commercially in San Francisco for a year and a half at the Marines Memorial Theater), The Wash, Threepenny Opera, and Dario Fo's About Face.
Other directing credits include The Pickle Family Circus (London Tour), King Lear at the Oregon Shakespeare Festival, As You Like It for the San Francisco Shakespeare Festival, A Midsummer Nights Dream for the California Shakespeare Festival, The Lion In Winter at La Mirada Theatre, Present Laughter and The Presentment for the Pasadena Playhouse, and productions at the Classic Stage Company and the Wonderhorse Theatre's in New York. He has also directed an award-winning 35 mm short film entitled Brass Tacks. Richard holds classes for professional actors in San Francisco and Los Angeles at Richard Seyd Acting Studios.
Michael Frayn (Playwright) was born in London on September 8,1933. After two years of National Service, during which he learned Russian, he read Philosophy at Emmanuel College, Cambridge. He then worked as a reporter and columnist for The Guardian and The Observer, publishing several novels including The Tin Men (1965), winner of a Somerset Maugham Award, The Russian Interpreter (1966), which won the Hawthornden Prize, and Towards the End of the Morning (1967). More recent novels include A Landing on the Sun (1991), which won the Sunday Express Book of the Year and Headlong (1999), the story of the discovery of a lost painting by Bruegel, shortlisted for the Booker Prize for Fiction. His latest novel, Spies (2002), a story of childhood set in England during the Second World War, won the 2002 Whitbread Novel Award and the 2003 Commonwealth Writers Prize (Eurasia region, Best Book), and was shortlisted for the Whitbread Book of the Year. Michael Frayn is also the recipient of the 2002 Heywood Hill Literary Prize. His plays include Alphabetical Order (1975), Clouds (1976), Donkeys' Years (1977), Make or Break (1980), Noises Off (1982) and Benefactors (1984). Copenhagen (1998), about the 1941 meeting between German physicist Werner Heisenberg and his Danish counterpart Niels Bohr, first staged at the Royal National Theatre in London, won the 1998 Evening Standard Award for Best Play of the Year and the 2000 Tony Award for Best Play (USA). His play Democracy (2003), is set in 1960s Berlin. His latest play for the Royal National Theatre is Afterlife (2008).
Recent books are Stage Directions: Writing on Theatre 1970-2008 (2008), and Travels with a Typewriter (2009). A book of memoir, My Father's Fortune: A Life, was published in 2010, was shortlisted for the 2010 Costa Biography Award, and won the 2011 PEN/Ackerley Prize.
He has also translated a number of works from Russian, including plays by Chekhov and Tolstoy. His films for television include First and Last (1989), for which he won an Emmy, and an adaptation of his 1991 novel A Landing on the Sun. He also wrote the screenplay for the film Clockwise (1986), a comedy starring John Cleese. Michael Frayn is married to the biographer and critic Claire Tomalin.
The cast of NOISES OFF will feature: Annie Abrams as Brooke, Rona Benson as Poppy, Leland Crooke as Selsdon, Joe Delafield as Tim, Bo Foxworth as Lloyd, James Lancaster as Freddie, Lori Larsen as Dotty, Jeff Marlow as Garry and Maura Vincent as Belinda.
NOISES OFF has assembled an award-winning design team. The Set Design is by John Iacovelli. The Lighting Design is by York Kennedy. The Sound Design is by Josh Bessom. The Costume Design is by Rose Pederson. The stage manager is Lisa Palmire.
NOISES OFF will begin performances on Friday, September 23, 2011 (with a press opening on Saturday, September 24) and runs for four weeks through Sunday, October 16.
Performances will be 7:30pm on Wednesdays & Thursdays; 8pm on Fridays; 2pm and 8pm on Saturdays; and 2pm on Sundays.
There will be no matinee performance on Saturday, September 24. There will be talk-back sessions following the performances on Wednesday, September 28 & Wednesday, October 12.
Tickets range from $35 - $50 and can be purchased at La Mirada Theatre's website, www.lamiradatheatre.com or by calling the La Mirada Theatre Box Office at (562) 944-9801 or (714) 994-6310. Student, Senior, Children and group discounts are available.


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Community groups can apply for their share of a £10,000 pot of funding available through Calne's area board to commemorate the centenary of the First World War.
Councillors hope the funding will inspire projects reflecting on the sacrifice made by servicemen, women, and their families 100 years ago.
Groups and parish councils can apply for up £1,000 and applications for projects, which must also benefit the wider community, should be handed in by March 20.
Board chairman Coun Alan Hill said: "What we're asking now is that people come forward with ideas for a project. It could be a piece of art, it could be a painting or even a garden, anything that people feel is a way of expressing their thoughts about this disastrous event in history.
"We're not unique, this is something that's happening across the county and across many parts of the world, we're just adding a tiny piece. "I believe that projects like these can help young people especially to realise what actually happened and to understand how the world ended up in a pretty terrible place.
"The lessons from that period of history are very definitely relevant today."
The £10,000 will come from the 2013/14 area board budget of £58,112 and the area board now has £22,028 left to spend on other community projects.
This is the second pot of funding released to fund centenary projects in Calne.
Pupils in Calne are also taking part in a £10,300 Lottery-funded project supported by the Calne Music and Arts Festival and the Calne Heritage Centre.
Pupils, from John Bentley, St Mary's and the Springfields Academy will research the town's wartime past and create a musical presentation based on findings.
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What is it?
The Portal Media Bluetooth TPMS module lets you monitor tire pressure wirelessly via Bluetooth.
The Verdict:
Portal Media's Bluetooth TPMS improves on the last generation of devices by allowing wireless communication via Bluetooth. The module is sleeker and reception appears improved. Once the kinks are worked out of the Android app, the Bluetooth TPMS module will be an awesome addition to any compatible car.
Quite a few years ago at mp3Car's first national car PC meet, I was lucky enough to win a prize for having as many as 19 USB devices connected to my car PC. The prize received was USB number 20, a car PC connected tire pressure monitoring system (TPMS) from Portal Media. Many years and several dead sensor batteries later, the device had served me well, but it was time for an upgrade. Luckily, the guys at Portal Media have been busy at work improving on their existing technology. For years it's seemed that the Bluetooth variant of their TPMS devices was simply an idea in our mp3Car forum, but the time has arrived, and the device really exists. I've been privileged to spend the last few weeks testing this new device out and getting to see if the wireless abilities actually improved the experience.
Let's get the obvious information out of the way first. The tire sensors required for the Bluetooth TPMS device must be professionally installed, so be sure to account for the cost of installation when considering this purchase. My cost was roughly $30/tire, but yours can vary. Also, as if this review, there is no Apple or Windows application that will work with the Bluetooth TPMS module. It's unknown whether this will be created by Portal Media in the near future, but as the mp3Car community is founded on the idea of tinkering and fitting square pegs in round holes, I'm sure solutions will exist shortly. Once the sensors are installed in the tires, the rest of the process of setting the system up is a breeze. The TPMS module is smaller and sleeker this time around, so it's easy to plug into any available 12v source and slide in a glove box or other compartment. It's recommended to install the device in a centralized location in relation to the tire sensors, but I've had far more success with reception despite installation location in comparison to the USB unit. Once the device is mounted and powered, the Android application will need to be downloaded from the Play Store. Once the app is installed, its time to begin the process of synchronizing the tire sensors to the Bluetooth module. Check out the video below on the steps required here.
The Android application for the Bluetooth TPMS is very easy to use. The user interface is very simple, and once the sensors are learned, it will quickly and accurately report sensor information. In the app settings, there are a large number of variables which control sensor alert notifications and display preferences. The app is not without faults though. I have the application installed on three of my Android devices; A Samsung tablet with QHD resolution, a Samsung smartphone with HD resolution, and the ODROID X-2 Android low resolution head unit. Each instance gives me a different take on the app. The smartphone displays the perfect scaling of text, buttons, and images. On the tablet, the buttons are very small and often a chore to press, and the vehicle image and text does not scale to make use of the added real estate. The ODROID's low resolution allows for the buttons and images to display correctly, but the text is too large for the bubble window it's presented in. Portal Media has acknowledged some of the drawbacks of the app, and is aggressively working to correct the issues.
Ultimately, the experience of being free of the installed car PC screen when dealing with my tire pressure is a much needed improvement. Rather than having to run back and forth between tires and the monitor to check pressure levels, I can take my tablet with me to each tire. I'll still receive alert notifications through my Android car PC, but the flexibility to use an additional screen when I choose is awesome.
The Positive:
• Module has a sleeker and smaller profile
• Tire sensor reception seems improved
• Android ability allows for cross-device usage
• Easy learning and setup process
The Negative:
• No current iPod or Windows support
• Android app is functional, but will need work
The Verdict:
Portal Media's Bluetooth TPMS improves on the last generation of devices by allowing wireless communication via Bluetooth. The module is sleeker and reception appears improved. Once the kinks are worked out of the Android app, the Bluetooth TPMS module will be an awesome addition to any compatible car.


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Library News :: List
Upcoming LHL Events: Afternoon Tea, International Tea & Coffee Hour
Join us for Afternoon Tea on Wednesdays in January & February from 12:30 to 2:30 in the sunroom at Lister Hill Library.
We will host an International Tea on Wednesday, January 23rd from 12:30 to 2:30 for UAB Community Week. Stop by for teas and treats from around the world.
Also as part of Community Week, Lister Hill Library is hosting Coffee Hour at the Smolian International House on Friday, January 25, from 11:30 to 1:00. We hope you'll stop by to enjoy some Southern food. Bring a friend or make new friends.
Posted on January 8, 2013@ 10:08 AM by Peggy


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Dhamma Greetings everyone,
My name is Zach and I have been practicing meditation for about 8ish years now. I am 33 years old and have done temporary ordination under my teacher I study under the most Ven. Bhante Vimalaramsi. I currently live in Farmington, MO in the Ozarks. Beautiful mountain country of Missouri. My monastic name is Ven Gunadasa when I ordained. Gunadasa means literaly a slave to doing good. I'm not sure what else I should type but remembered I had this profile a whiles back. I am a serious practitioner to just watch and see what happens in meditation with the curiosity of a child's mind. Longest sittings I can do is about 3 hours or until my legs fall asleep, haha. I study Dependent Origination which is spoken about many times in the majjhima nikaya. That is the main book I read as well. As far as progress goes... I practice TWIM(Tranquil Wisdom Insight Meditation) a nice perfect blending of vipissana and samantha yoked together as spoken about in the Buddhist Suttas. I use the brahma viharas as my meditation object. As far as Jhannas are concerned I am not afraid to speak about them nore am I afraid to help give teachings if practicing with TWIM. I have exerienced all Jhannas except Relam of neither perception nor non perception. I am a firm believer we are reborn and not reincarnated... I do not believe in a permanent me, myself, or I that survives after death, but do believe our khamma and habitual tendencies are transmuted into a new being based on our khamma of our past life(s) and our current mind state at time of death along with merit we earn by doing good. Most of my progress in Buddhism has been made from having insights in sitting meditation or carrying the sitting meditation into waking life because I believe what the Buddha said... Meditation is life and life is meditation. I hope all may find relief and be happy!!!
Much Maha Metta Everyone!!!


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Paul Zak and the Neurology of Neighborly Exchange
A stoop sale in Brooklyn. (photo: click wrrr/Flickr)
Earlier this summer, I spent more money than I wanted to on camping equipment — hiking poles and other gear I won't likely use off the trail. Maybe I should have asked a neighbor to borrow or rent their stuff instead. Not only would I have saved some dollar bills, but my brain might have gotten a neurological boost as well.
That's according to neuroeconomist Paul Zak, who was recently quoted in The New York Times about the benefits of participating in neighborly economic transactions — for example, renting a pricey Roomba from someone down the street rather than buying one from a big box store. According to Zak:
"There is an underlying notion that if I rent my things in my house, I get to meet my neighbor, and if I'm walking the goods over, I get to meet them in person … We're drawing on a desire in a fast-paced world to still have real connections to a community."
Krista interviewed Zak for "The Science of Trust: Economics and Virtue," a show we produced in 2009 as the Great Recession was unfolding. He does research on oxytocin, a powerful neurotransmitter known as "the trust hormone" that's commonly associated with breast feeding and childbirth but is also triggered by other forms of social bonding.
Zak's work around trust and transactions reminds me of a different story altogether from Khalid Kamau, who was featured in our Repossessing Virtue series on the economic crisis. Kamau's reflection about borrowing eggs and milk from a neighbor hints at a collective longing to belong to a supportive social fabric.
All of this has me wondering how and whether these trends might be playing out in your own life. Are you sharing or in some way participating in neighborly exchanges of goods and services? If so, have you experienced a greater sense of belonging or social connection as a result? Share your oxytocin story with us.


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Freedom is hammered out on the anvil of discussion, dissent, and debate. --Hubert H. Humphrey
Does the news drive the technical action or does the technical action drive the news?
Technicians will tell you that the way that news is perceived is a function of the level of prices. News that is viewed as positive when the market is at a low will often be viewed in the opposite manner when the market is at a high.
We have a good example of this tendency right now as we contemplate the fiscal cliff issue. A little over week ago it was good news that there was general agreement about trying to resolved the fiscal-cliff issue. The market was technically oversold and it was a great reason for a bounce to ensue.
Now that we've bounced and are heading into key overhead resistance levels, the discussion of the fiscal cliff is turning more negative with comments from Senator Harry Reid about there being little progress, causing some selling.
Technically, the market bounced nicely when it was oversold and now it is starting to falter as it becomes extended and hits resistance. In both cases, it was news about the fiscal cliff that was the fundamental catalyst for the action.
The problem now is that after the obvious bounce into resistance, things are quite muddled and this lack of clarity is reflected in the fiscal-cliff debate. There is still a high level of anticipation that a deal will be struck, but there is plenty of nervousness about it and a high level of distrust in our political leaders. It is hard to believe that they would fail to make a deal, but the ideological stubbornness can't be underestimated.
We are obviously going to be held hostage by this fiscal cliff debate for a while, but overall the technical pattern of the market isn't bad. The SPDR S&P 500 (SPY) has bounced right into resistance at its 50-day simple moving average and it's pulling back and consolidating, as some who caught the move are locking in gains and bears are reloading shorts.
The big technical issue is whether the market rolls back over and tests the recent lows, or does it churn and pull back a bit, build support and make another thrust higher? I'm inclined to believe the latter and will be watching for the market to find support. It would actually be a positive if there was basing action for a while that would allow charts to set up.
One thing we have often missed in this market the last few years are periods of flat action where the new crop of winners come to the fro. It too often goes straight down and straight up and never has a good transitional period. I blame that on the liquidity from quantitative easing, which may no longer be the factor it once was.
For now, we have little choice but to listen to this constant debate over the fiscal cliff. I am optimistic it will be resolved and will be a positive market catalyst, but I'm afraid it isn't going to happen until very close to the deadline. The market should start anticipating a resolution, but comments like those from Senator Reid yesterday are going to be landmines for traders.
My strategy is to be optimistic but to stick to very short-term trading until the cloud from the fiscal cliff lifts. We are going to be held hostage by this news and that means we can't carry munch inventory until there is greater clarity.
We have a little early pressure as the media obsesses over the fiscal cliff debate. Unfortunately, it isn't going away anytime soon.


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While reports of possible NCAA violations percolate around the Auburn football program and are being vehemently denied, another tale has arisen. This one involves alleged use of synthetic marijuana by members of the 2010 Tigers team that won the BCS national championship.
Auburn officials responded late Thursday by calling the allegations baseless and inaccurate.
That team, coached by Gene Chizik and led by Heisman Trophy-winning quarterback Cam Newton, was rife with use of the designer drug with the street name of "spice," according to ESPN.
There has been no information implicating Newton, who now plays for the NFL's Carolina Panthers.
"I'm going to let the right people to talk about it," Newton said, according to AL.com. "Of course I'm concerned, but I think the truth will come out."
Chizik was fired after the 2012 Tigers finished 3-9.
This week, a report alleged Auburn football players received money and had grades altered to maintain their eligibility. Chizik and others mentioned in the report by former Sports Illustrated and New York Times journalist Selena Roberts have strongly denied the allegations.
ESPN's report claims Tigers football players failed numerous drug tests. One the players mentioned was running back Michael Dyer, who is a sidebar story in the latest allegations involving the football program.
According to the ESPN probe, dozens of seniors on the team that won the national title in January 2011 avoided detection because the school didn't begin testing for the drug until after the season ended.
The report also says that Dakota Mosley, at the time a freshman tight end, failed seven consecutive weekly tests but escaped punishment.
"The whole time, I was thinking, 'They can't do nothing about the spice,' " Mosley told ESPN The Magazine and affiliated TV news program "E:60."
Mosley and three teammates later were arrested in connection with an armed home invasion robbery, and then indicted. All four were dismissed from the football team.
Former player Antonio Goodwin was convicted in June 2012 and sentenced to 15 years in prison.
Former safety Mike McNeil faces trial next week. He testified on Goodwin's trial and admitted to using synthetic marijuana.
A trial for Shaun Kitchens has not been set.
Mosley also could face trial at some point.
Dyer rushed for 1,093 yards as a true freshman at Auburn and was the Most Valuable Player of the National Championship Game. He followed Gus Malzahn, then Auburn's offensive coordinator, to Arkansas State, where he was dismissed after being caught with marijuana in a traffic stop. Malzahn is now Auburn's head coach, and Dyer is on the Dean's List at his current school, Arkansas Baptist, his uncle told al.com.
McNeil sat out the 2012 football season after being denied eligibility by the NCAA.


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School board OKs high-interest bond measure
BAKERSFIELD, Calif. (KBAK/KBFX) Lakeside Union School District's board unanimously approved a high-interest bond measure Tuesday night.
The district is moving forward with a $10.3 million bond measure to cover bond debt coming due in June.
The district is turning to a capital appreciation bond, which could carry interest as high as $6 for every $1 borrowed.
The bond measure could also increase property taxes in the Lakeside district, which operates Lakeside School on Old River Road and Suburu School on Harris Road.


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Indians' clubhouse buzzing about LeBron news
Swisher, Francona excited NBA star is returning to Cleveland
CLEVELAND -- The Indians made the postseason last season. The Browns recently drafted quarterback Johnny Manziel and all the hype that came along with him. On Friday, NBA superstar LeBron James announced that he is officially heading back to the Cavs.
The Cleveland sports scene and the city itself have been experiencing a comeback.
"This city's really kind of reinventing itself," Indians first baseman Nick Swisher said. "Obviously we've had some glory years in the past, but we're in the now and things look on the up and up for everybody. From the Browns to the Cavs to the Tribe, it seems like everyone's really stepped their games up.
"And, obviously, King James is back in the building. There's a lot of excitement. I can't wait to meet him. I'm just so stoked he's coming back. A guy like that, with the talent he has, singlehandedly that guy can win you a championship, for sure.
"Just in general, Cleveland sports are really pushing themselves in the right direction, and we're putting ourselves back on the map."
In the middle of the second inning, the Indians displayed James' image on the scoreboard behind the left-field bleachers. As the words "Welcome Home" appeared on the screen, the fans inside the ballpark erupted in loud cheers.
At the Cavs' Quicken Loans Arena, which sits directly across a plaza from Progressive Field, fans were gathering to celebrate James' return on Friday afternoon. Inside the Tribe's home stadium, Indians manager Terry Francona also expressed excitement over what James' decision could mean for the city and Northeast Ohio.
"I haven't been here as long as you guys," Francona said, "but I've been here long enough to care about Cleveland. First and foremost is what we're doing here with the Indians. That's my job. As far as being a person, I'm thrilled, because it's going to bring a lot of happiness and a lot of joy to basketball fans.
"I think it's good for the city, bringing in revenue and extra excitement to the downtown area. I think it's awesome. For the basketball fan in me, I'm really excited."
Jordan Bastian is a reporter for MLB.com. Read his blog, Major League Bastian, and follow him on Twitter @MLBastian. Alec Shirkey is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.