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When I look around my home, I see signs of my husband everywhere: photos of the family to whom he is devoted, an Acosta Family crest, prints of Italian Renaissance, French Impressionist and Picasso masterpieces. I see his vision – always pointed at the horizon – in our remodeled kitchen and bathroom. The vegetable garden, the roses, the carefully tended lawn – that's all him, too. I even see him in our appliances, every last one purchased at discounted prices with a firm adherence to both quality and value, not sacrificing one for the other.
Simply noting the material things, you hardly see me at all. The bookshelves contain a lot of me, but my stuff accounts for just over half the items resting on them. There's a Japanese doll standing in a far corner of the house in a spot you wouldn't notice unless you were really prowling around. And I'll claim the family photo display, too.
But just because you can't see me doesn't mean I'm not there. In fact, I'm everywhere – in all the blank, unseen spaces. I'm from the "less is more" school of thought and apply it to everything: how many flowers you put in a vase, how much clothing you pack for a trip, how many back issues of a magazine you keep in the house, how much dressing for a salad. So where you can find me in the home is in the absence of clutter and knickknacks.
I'm also in floors, which are repeatedly vac- uumed (oh, that darn dog hair!) and wiped down, because I like things clean – not just looking clean, but actually being clean. And in stark contrast to my husband, who would have trouble locating the scotch-tape, I know where everything is. But if you had to find something without my assistance, you would discover that everything is kept neat and well organized, something you'd never know by just glancing around. My imprint lies literally behind closed doors: hall closets, kitchen drawers, pantry shelves.
I believe in invisible things like energy and emotion – again, just because you can't see it doesn't mean it's not there. I therefore take cleanliness to the next level by burning incense or sage periodically to ensure a well-balanced energetic environment. I have no evidence that it makes any difference whatsoever, but I definitely feel better afterward. The atmosphere in my home seems more peaceful, more relaxed and somehow lighter when I'm done.
I crave emptiness: a nonexistent mess, the space along the mantel, items donated to Goodwill that my mind no longer keeps track of. I pay a lot of attention to the things you can't see and what's not there. That's where my comfort and security lie.
When I walk into any room, it's my husband's taste and interests that grab my initial attention. It kind of reminds me of a dog marking all over the house. But that's not a completely accurate image of our home. My husband may dominate the visual landscape, but I'm right next to him, leaving my own tracks. I'm in all the empty spaces. To find me, you have to look a little deeper.


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Highlights clips trace the award-winning director and producer's best work, from a career of more than 50 years.
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subset: commoncrawl


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After studying and practicing the Bhudda's dhamma for some time now, I had been stopped at the point of not "seeing" non-self. On a whim, I decided to read the Upanishads merely to understand the Hindu tradition, and maybe know more about the traditions pre-dating and related to the Bhudda's dhamma. The Upanishads, contrary to the Dhamma, are a celebration of self, an invocation to find the self, a Supreme Self, becoming one with reality. However, through reading the Upanishads I came to understand better what the concept of Self implies and means, what the Bhudda meant about not-self, and how acceptance of a real concept of Self is intrinsically tied up with craving for this Self, and suffering results due to volitional action of chasing after this elusive self. Perhaps this all links into dependent origination, it is hard to know.
So, the purpose of this message is to encourage fellow practitioners to study and contemplate the Upanishads, and see what understanding you can gain about the Self, and self as Brahman, as reality, and contemplate the implications of that. I have found it to be of great benefit in my personal practice. The concept that arose during meditation, was of my birth, naming, crying and the response of others to that crying, this level of interaction. Thereafter. I could see that my "I, me, mine" arose from the conditions at birth, for example, the response of others to my crying perhaps cemented my perception of a self, and it went forward from there, the ego being formed from this chain of causation. "I" can find the irony, in having gained better understanding of non-self, by studying a different tradition that seems to have wrong view according to the Dhamma. May be as they say, the Dhamma is everywhere. On some level, I get the sense that the stories told by the Upanishads, although seemingly teaching contrary to the Dhamma, maybe it does not teach wrong view, but only explain one facet of the Dhamma. Perhaps the Bhudda understood this and took the concept of Brahman and Atman, and understood that when followed to the end, it is empty of anything that could be related to, in the sense of "exists or does not exist."
That is what "I" got from the Upanishads. To read these Hindu texts, seems beneficial for the insight that they offer into self, for the better understanding of non-self. As much as the Upanishads encouraged unification of the ego with the ultimate self, the Dhamma practice inclines us toward dropping any concept of this. So maybe to drop self, it's useful to understand the concept of self and then look for where this concept lies in our own minds.


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Posted 5 years ago
(113 items)
I bought this at the local flea market. I thought it was a railroad lantern and didn't pay much attention to it until I was later told that it's not. It's a Traffic Gard (that's how they spelled it) #40. Was told that the old road crews used these lanterns after dark to warn people about construction and other issues along the road.


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Seafare Inn
Rating: 2 stars.
Where: 16363 E. Whittier Blvd., Whittier.
When: Lunch and dinner, Tuesday through Sunday.
The food: Not so much a restaurant as a local institution. Dating back to Aug. 8, 1961, this venerable seafood house, far from the ocean, offers some of the best fish in town, reasonably priced, a wide selection of classic dishes that have been on the menu since the beginning — from seafood Louie to Manhattan clam chowder, from avocado stuffed with shrimp, crab and lobster to fried Ipswich clams. A taste of how we used to eat, back in the day.
How much: About $18 per person. MC, V.
Beverages: Beer and wine.
Reservations: Helpful.
Information: 562-947-6645, www.seafareinn.net.
There are many reasons to like the old Seafare Inn on the eastern edge of Whittier. The space is cozy, the food is even cozier and the staff is as friendly as could be. Dining here is like slipping into a well-worn, much loved pair of jeans.
But there's also a fair amount of affection to come from the restaurant's unwavering attachment to its past and, by extension, to our past. So much so, that the website actually features a copy of the original menu — from back on Aug. 8, 1961, when the Seafare first started broiling, frying and grilling fish.
Over the years, the menu has changed — a little. But not much.
I do wish I had been around back then. There was a gooey duck sandwich made with an oversized clam from the Pacific Northwest that's famous for having a long tube that hangs out like a bit of firehose. There was an abalone sandwich as well. There was deviled crab, a dish I'd love to have tasted — think deviled egg, but with crab, sounds wonderful. There was an oyster stew and, of course, prices were a lot lower half a century ago.
These days, there's a far more substantial menu with at least three times as many dishes, maybe even four times as many. Yet, it's still a modest collection of seafood preparations. This is not one of those Hong Kong seafood palaces with north of 300 options on the menu.
If you're here for the classics — really, where to begin? So much of the menu is a Smithsonian of great dishes.
At the top, we've got the seafood cocktails, a genre that's been replaced over the years at other restaurants with ceviche and poke and crudo and sashimi and the like. But not here at the Inn. These are proper seafood cocktails, served in a proper seafood cocktail dish — shrimp, crab, lobster or all three mixed together. (There's a marinated herring seafood cocktail as well, which is admirably eccentric.)
The Manhattan clam chowder is pretty much essential, served both small and large, and bucking the general trend toward New England clam chowder. I'd say nine places out of 10 offer white New England rather than red Manhattan, which has always reminded me of a casual version of cioppino. In this case, it's a good soup, with lots of vegetables and the occasional clam that pops up on your spoon. It sets a tasty tone for the meal.
I love that the Inn offers four seafood Louies — shrimp, crab, lobster or a combo of all three — and the same options with the stuffed avocado. The dishes are so totally out of a long-lost consciousness. (I wonder why they only stuff their tomato with tuna? It may be a tradition long lost to history.)
Littleneck clams are served on the half shell and steamed. Oysters are served on the half shell and not as oysters Rockefeller. You can also get a combo of raw oysters and clams — another good idea.
You shouldn't be surprised to find crabcakes and fried calamari on the menu, nor should you be surprised to find that the options for the seafood are broiled, fried and grilled. But this isn't a sauce restaurant so don't expect sole meuniere or anything like that. You want your sole, you get it grilled served with two side dish choices. I like the coleslaw and the french fries. And I did a double take when I noticed that one of the side dishes is cottage cheese — that is so Eisenhower! And so, for that matter, is the choice of butter or margarine. These days it's usually butter or olive oil. But that's far too modern.
Back in the early days the only dessert was ice cream, but over the years they've added sherbet, "chocolate surprise cake" and cheesecake. And look at this — a real eyebrow raiser — creme brulee, not a dish I'd expect to find on a menu that offers cottage cheese as a side dish.
But for the most part, the old Seafare Inn sails straight and true. There's no prime rib on the menu, no braised short ribs, no monkfish, no Prince Edward Island mussels. The closest the Inn comes to meandering off the reservation is with the grilled lemon-pepper chicken breast. Though I guess the grilled cheese sandwich has an edge of born-again modernism. But for most of us, it's something you eat on a cold day with tomato soup. Or in this case, Manhattan clam chowder.
Merrill Shindler is a Los Angeles-based freelance dining critic. Send him email at firstname.lastname@example.com.


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Hi all
In Australia, its Mother's Day today.
Whether or not you believe days like Mothers Day and Fathers Day are just concocted by card manufacturers to sell more product, I think it provides us with a great opportunity to think of the great good work of our grandmothers, mothers, wives, sisters and daughters and our friends. My own teacher says that our debt of gratitude towards our parents can never be repaid unless we have the opportunity to introduce them to the Dhamma.
Yet, for many of us, we live in societies where the most important job in the world, motherhood, is unrecognized and unappreciated.
Please join me in extending metta to all those who have brought us and all those whom we love into the world.
May all our mothers, wives, sisters and daughters be happy, be free from misery.
May they all share in our merits.


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Hewlett Packard
26 Jan 2013 at 07:17
simon this is the birthplace of computers and one of the starting points to the silicon valley. This garage is where HP's founders Bill and Dave started HP. HP is a global business, but every business must start small. Hey simon you are flat, can you fit under the garage crack?
With simon
View All 1 Comments
Very cool, Carlos!
be the first to like this Like


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By Jaideep Varma and Jatin Thakkar
Pakistan won the Asia Cup but the 3 highest impact players of the tournament included 2 Bangladeshis and 1 Indian. Pakistan played as a team, absorbed pressure very successfully and won the big moments. They were worthy winners.
Here is an overview of the series through the Impact Index lens.
Shakib Al Hasan was the highest impact player in the series. He was also the second-highest impact batsman in the tournament. He had the highest Strike Rate IMPACT while absorbing considerable pressure in the tournament. He recorded three IMPACT 5 match performances in the tournament and failed only once as a bowler in the match against India (where he still contributed as a batsman though).
He was closely followed by Tamim Iqbal (third-highest impact player in the tournament). Tamim registered the highest Chasing IMPACT for Bangladesh in the tournament, absorbed a considerable amount of pressure while batting and recorded a 0% failure rate like Shakib as a batsman.
Virat Kohli was the highest impact batsman of the tournament and the second highest impact player. He registered the highest Chasing IMPACT in the series and also absorbed the maximum pressure for India, all this while recording a healthy Strike Rate IMPACT. His innings of 183 was the highest impact batting performance in the series. He was also the highest impact fielder in the tournament.
Three Pakistanis follow on the IMPACT list – all-rounder Mohammed Hafeez, wicketkeeper-batsman Sarfraz Ahmed and Shahid Afridi.
Interestingly, Mohammed Hafeez was also the only player besides Shakib to have an all-round impact in the tournament. He was also the highest impact batsman for Pakistan in the tournament.
Sarfraz Ahmed was the highest impact wicketkeeper-batsman in the tournament. His attacking effort as a batsman in the final match helped Pakistan post a total that ended up being enough as Bangladesh cracked up under pressure near the end – that performance and his Wicketkeeping IMPACT in that match together achieved a Tournament-Defining status.
Shahid Afridi had a mediocre tournament by his standards (even missing out on all-rounder status as his Batting IMPACT failed to cross 1 in the tournament) but he largely made up for it with a quintessential all-round performance in the finals which achieved Tournament-Defining status.
Kumar Sangakkara is next on the impact charts - Sri Lanka's highest impact player in the tournament for his dual wicketkeeper-batsman role. He was the second-highest impact batsman for Sri Lanka – his hallmark was maintaining a positive Strike Rate IMPACT despite absorbing pressure.
Sri Lanka, visibly tired from their exertions at the CB Series in Australia were largely uninspiring otherwise. Their highest impact bowler Malinga failed to take any wickets in the tournament, a big reason for their flatness.
Umar Gul was the highest impact bowler in the tournament for Pakistan followed by Saeed Ajmal. Gul was the second-highest impact bowler in the tournament when it came to building pressure (quick wickets) and had the highest Partnership Breaking IMPACT in the tournament. Ajmal was amongst the top 5 bowlers in the tournament for Economy IMPACT and also showed ability to break partnerships.
Typically, most of the attention when it came to Bangladesh's performance went to the batsmen, but Nazmul Hossain's contribution cannot be ignored. He was the highest impact bowler for Bangladesh in the series but played just 2 matches as he missed the first 2 ODIs.
Nazmul showed the ability to clean top/middle order wickets, alongside Umar Gul. In fact, Bangladesh's top 5 bowlers in the tournament were also amongst top 10 bowlers in the tournament – the biggest key to their success – not something that too many people seemed to speak about.
MS Dhoni with a Batting IMPACT of 1.39 (overall 2.58) and R Ashwin with a Bowling IMPACT of 2.45 were the highest impact Indian players after Kohli. Tendulkar was next, with an IMPACT of 2.30 – actually, he can be seen as a high impact player for Bangladesh – they owe him greatly, as his selfish batting in the India-Bangladesh match, when he went after an oppressively elusive utterly meaningless statistical landmark, resulted in a team score that was at least 30 runs short on that pitch. Blaming the bowlers for not being able to defend 290 on that pitch is myopia of the highest order that only the unique brand of blind Tendulkar-worship in our country can inspire.
The fact that the next highest impact player for India after Kohli, Dhoni, features 13th on the list above, isn't a healthy sign as a team for India. If one excludes Kohli, India's Team IMPACT in the tournament goes down to 1.50 from 1.87, the same as Sri Lanka's who failed to win even a single game in the tournament.
Pakistan's Team IMPACT in the tournament was 2.00, well ahead of India (1.87), Bangladesh (1.84) and Sri Lanka (1.50). Only one Sri Lankan crossed a Match IMPACT of 5 at any stage during the series, Bangladesh and India registered 3 of those. Pakistan had 6 – perhaps the most revealing facet of their victory, despite just winning by 2 runs in the final. There is no doubt that the best side won.
For more information, please go to www.impactindexcricket.com
By Jaideep Varma and Jatin Thakkar


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Posted 7 years ago
(1 item)
This is a beautiful piece of furniture and I enjoy using it in my home but I have never been able to find another one like it. I was told that it came from an old post office in Texas. Anyone have any ideas as to what it is or its value?


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'The players' association is devising its next step while striving to retain unity. The players are publicly together, but the 700-plus members are eager to get on the ice, and some may have wanted to accept the NHL's offer. They could follow the lead of the previously locked-out football and basketball players and file a disclaimer of interest, which allows unions in an untenable financial position a chance to dissolve. With no union, the lockout would be declared illegal.'
You are here: Home / SabresBeat / Lost season looms as NHL talks break down


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Taking Medicines for Heart Conditions
Taking Medicines for Heart Conditions
What do I need to know if I am taking medicine for my heart condition?
The treatment of most heart conditions requires the use of prescription drugs. In fact, many people need to take many different pills, several times each day, to treat their heart conditions.
Follow your doctor's instructions
Medicines only work if they are taken properly. So it is very important to understand how many times per day each medicine should be taken and exactly which dosage you should be taking. It is also extremely important that you take these drugs at the prescribed times and in the prescribed dosages. If you do not take your medicines the way they are prescribed, they may not work properly. Not following your doctor's instructions may result in ineffective treatment that may lead to serious complications of your condition.
Adding a medicine regimen into your lifestyle can be a challenge and requires a strong commitment on your part. Your medicine schedule needs to become a routine part of your daily activities. If you have trouble remembering when to take your medicines, you may find the following tips useful.
Managing your medicines
- Organize your medicines in a pillbox so that you do not mistakenly skip any doses.
- Set a watch alarm to avoid missing scheduled medicine times.
- Schedule medicine times on a handheld computer or in an appointment book.
- Ask a friend or family member to help you organize your medicines and remind you when it is time to take them.
- Keep a detailed list of all medicines you are on, including a description of their color and shape. If your doctor changes your medicines, it will be easier to tell them apart.
- Take medicines at the same time every day in order to incorporate them into your regular schedule.
- Carry an extra dose of medicines with you when leaving the house, just in case you are unable to return home in time for the next dose.
Keeping good records
Keep detailed records of your medicine treatment, including:
- A notebook with an up-to-date list of the names and dosages of your medicines.
- A list of medicines that you used to take and notes about why they were discontinued.
- A list of any medicines you are allergic to or had an adverse reaction to and descriptions of each allergic or adverse reaction.
- The name and phone number of your pharmacy.
- The names, phone numbers, and addresses of all your doctors.
- Charts of your weight, blood pressure, and heart rate (as often as they are measured).
What if I miss a dose of my medicine?
If you miss a dose of one of your medicines, you should discuss the situation with your doctor or a nurse. For some medicines, missing one or two doses does not cause a major problem. For other medicines, missing a single dose can cause serious problems.
You should NOT assume that if you miss a single dose, the next dose should be doubled. Many medicines can cause significant problems and even long-term health concerns if taken in a double dose.
Changes in your medicine treatment
It may also take some trial and error for you and your doctor to find a medicine or combination of medicines that effectively manages your condition and symptoms. For this reason, you may end up trying a range of medicines within one medicine class or across a number of medicine classes.
Make sure that you discuss any changes in your medicines with your doctor. Your medicine regimen has been prescribed for a reason, and even slight changes can greatly affect its effectiveness.
Interactions with other medicines
The medicines your doctor prescribes may sometimes interact with other prescription or nonprescription medicines as well as any other dietary supplements or herbal remedies. It is therefore important to be aware of which substances will interfere with your treatment regimen. You should tell your doctor about every substance you are taking on a regular basis, whether it is a prescription medicine, an over-the-counter remedy, or an illegal drug.
What important facts should I know about medicines for heart conditions?
The treatment of most cardiac conditions requires the use of prescription medicines. The amount of time that you will be required to take medicines will vary depending upon your specific medical condition. Some people will stop taking medicines when an appropriate level of rehabilitation has been reached. Other people will be required to take medicines for the rest of their lives.
Your doctor may prescribe many medicines for you. Your ability to know and understand the purpose of each medicine is important. For each medicine, you should be able to answer the following questions:
- What are the generic and pharmaceutical names?
- What is the correct dosage?
- When and how often should I take it?
- What is it supposed to do inside my body?
- What side effects can I expect?
Current as of: August 21, 2015
Author: Healthwise Staff
Medical Review: E. Gregory Thompson, MD - Internal Medicine & Theresa O'Young, PharmD - Clinical Pharmacy
This information does not replace the advice of a doctor. Healthwise, Incorporated, disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use . Learn how we develop our content .
To learn more about Healthwise, visit Healthwise.org .
© 1995-2016 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


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The destruction resulting from weather disasters of 2011 has notched a new, albeit unwelcome, record. For the first time, the number of U.S. weather-related disasters in one year causing $1 billion or more in damage has reached 10. The previous record of 9 was recorded in 1980.
Drought, floods and tornadoes have taken their toll on families, communities and farms across the nation, causing hundreds of fatalities and an estimated $35 billion in weather-related damage, according to Chris Vaccaro, director of public affairs at NOAA's National Weather Service. From a crushing blizzard that piled up nearly two feet of snow in Chicago, to wildfires that have burned over 1,000 homes in Texas, Mother Nature has been on a rampage.
While some climate experts cite global warming, others blame the influence of La Nina. Still others just blame bad luck. With three more months before the destructive year ends, some even dread the thought of adding to the record.
The National Climatic Data Center (NCDC) is the "Nation's Scorekeeper" in terms of addressing severe weather or climate events in their historical perspective. As part of its responsibility of "monitoring and assessing the climate," NCDC tracks and evaluates climate events in the U.S. and globally that have great economic and societal impacts.
In chronological order, the top weather disasters in 2011 are:
Groundhog Day Blizzard, Jan. 29-Feb. 3 Large winter storm impacting many central, eastern and northeastern states. Chicago was brought to a virtual standstill as between 1 and 2 feet of snow fell over the area.
Midwest/Southeast Tornadoes, April 4-5 Outbreak of tornadoes over central and southern states with an estimated 46 tornadoes.
Southeast/Midwest Tornadoes, April 8-11 Outbreak of tornadoes over central and southern states with an estimated 59 tornadoes.
Midwest/Southeast Tornadoes, April 14-16 Outbreak of tornadoes over central and southern states with an estimated 160 tornadoes.
Southeast/Ohio Valley/Midwest Tornadoes, April 25-30 Outbreak of tornadoes over central and southern states with an estimated 305 tornadoes causing 327 deaths. The deadliest tornado of the outbreak, an EF-5, hit northern Alabama, killing 78.
Midwest/Southeast Tornadoes, May 22-27 Outbreak of tornadoes over central and southern states with an estimated 180 tornadoes and 177 deaths. Notably, an EF-5 tornado struck Joplin, Mo., resulting in at least 141 deaths, making it the deadliest single tornado to strike the U.S. since modern tornado record keeping began in 1950.
Southern Plains/Southwest Drought, Heatwave, & Wildfires, Spring-Summer Drought, heatwave, and wildfires created major impacts across the Texas, Oklahoma, New Mexico, Arizona, southern Kansas, and western Arkansas and Louisiana.
Mississippi River flooding, Spring-Summer Persistent rainfall (nearly 300 percent normal precipitation amounts in the Ohio Valley) combined with melting snowpack caused historical flooding along the Mississippi River and its tributaries.
Upper Midwest Flooding, Summer Melting of an above-average snow pack across the Northern Rocky Mountains combined with above-average precipitation caused the Missouri and Souris Rivers to swell beyond their banks across the Upper Midwest.
Hurricane Irene, Aug. 20-29 While it will take several months to determine an accurate estimate of the damage from Hurricane Irene, there is no question it will rank as the 10th billion-dollar weather/climate event of the year.
Source: NCDC


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Colorado Rockies first baseman Todd Helton was arrested Wednesday morning and charged with driving under the influence of alcohol, The Denver Post reports.
The arrest occurred in Thornton, Colo., a Denver suburb where Helton lives year-round, the Post reported. Police reported stopping him at 2:39 p.m. local time a few blocks from his home.
Another TV station reported Helton was seen driving erratically. A witness notified police.
He was taken to city jail before being released to what a Denver TV station called "a responsible party." A county prosecuting attorney could follow up with criminal charges against Helton.
Helton, 39, enters his final playing season in baseball. The Rockies will report training camp beginning Feb. 10.
The team released this statement: "We were extremely disappointed to learn that Todd was arrested this morning. This type of behavior is taken very seriously by our organization. We know that he clearly understands the seriousness of his poor decision, the harm that could have been inflicted on others and the embarrassment his mistake has caused to himself, his family, the Colorado Rockies organization and to Major League Baseball. Todd is taking full accountability for his actions with his family, his fans and the organization. The man we have grown to know has strong values that are grounded in his family and hard work. Todd clearly understands the severity of the situation."
WITRADO: MLB ignores its DUI problem
Helton released this statement, according to the team's website: "Last evening I exercised poor judgment and was charged with drinking and driving after driving to a gas station near my house. I am very sorry and embarrassed by my actions. I hold myself to a high standard and take my responsibility. I sincerely ask my family, the Colorado Rockies Organization, Major League Baseball and the community to accept my apology. I make no excuses and accept full responsibility for my actions. I humbly ask your forgiveness."
Helton recently announced that he would return for his 17th season in the majors after briefly contemplating retirement following last year's season-ending hip surgery.
In 69 games in 2012, Helton hit .238/343/.400 with seven homers and 37 RBIs.
The five-time All-Star, three-time Gold Glove winner and 2000 NL batting champion has spent his entire career with the Rockies and is a career .320/.419/.545 hitter with 354 homers and 1,345 RBIs.
Helton will be paid $5 million this season in the final year of a two-year contract extension.
Photo Gallery: Athletes who have been charged with DUI


text: I think Lance would be incredibly effective in the 2nd unit. Augustine is not a playmaker. Lance is. Lance would create a matchup problem because Augustine would be playing SG and be a three point threat. I think it would open everything up in the 2nd unit to be honest. And I agree with the previous post. PG has the handles this year guys. He can handle it.


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How far would you go for revenge? For survival? Former model turned forensic psychologist and PI Mak Vanderwall is missing, presumed dead in Paris. By hiring a hit man to kill her, the powerful and corrupt Cavanagh family aimed to silence her for good. But after narrowly escaping death, Mak has taken over her would-be killer's world. She is very much alive. And transformed....
Back in Sydney Mak's former flame, criminal profiler Andy Flynn is on the trail of a vicious rapist and murderer with possible ties to the infamous 'Stiletto Killer'. He may have struck before and will certainly do so again. And while Andy struggles to cope in a world without Mak, little does he realise she is on her way back. And this time she's ready to make her own justice.
©2012 Tara Moss (P)2011 Bolinda Publishing Pty Ltd
Main interests are crime, some science fiction, fantasy & comedy. Also very interested in playback hardware for audio books.
"Not in audio again"
My gripe only applies to the audio production, & that relates to using a foreign reader for for a story set largely in Australia. After some hours of hearing our place names mis-pronounced, I am considering whether I'll stick it out to the end.
Any future Tara Moss I read will be in print.
Report Inappropriate Content
If you find this review inappropriate and think it should be removed from our site, let us know. This report will be reviewed by Audible and we will take appropriate action.


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HOU gets:
Danny Granger
Gerald Green
IND gets:
Jeremy Lin
Omar Asik
Patrick Beverly (or Peyton Siva)
Thomas Robinson
This deal fills out our roster at with a ridiculous bench and upside too. This saves Hou about 4.5M to open up signing Dwight. It pairs him with an outside shooter and rounds out their wing situation. We get oyur backup PG and a PG to develop. We take on a little extra salary but get extra talent. Win Win. Let me know what you think.


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Grandpas and grandmas need extra-special love during the holidays. Show them you care with these gifts from the heart.
On Donna:
Daria De Koning's 'Tango' earrings with white topaz and freshwater pearls in 18-karat white gold, $2,250, Elleard Heffern Fine Jewelers
Black and ivory Amber Sun sweater, $89, Nordstrom
Teal Amber Sun long-sleeved shirt, $32, Nordstrom
On Bill:
Private label brown cashmere sweater, $595, Neiman Marcus
--A lovely necklace for a lovely lady: Black Bakelite and Olive Quartz pendant on brown silk link cord, $550, Elleard Heffern Fine Jewelers
--Nothing gives you warm fuzzies like UGG cozy knit slippers, $120, Saks Fifth Avenue
--Help her sparkle with Elleard Heffern's '7 Days' sterling silver bangle bracelet set, $250, Elleard Heffern Fine Jewelers
--Grandma is in-the-know with Fownes Brothers touch screen-compatible black gloves, $69, Nordstrom
--Chic and sophisticated blue cashmere scarf, $88, Nordstrom
--Sweets for the sweet: Gourmet truffles, $34, Lake Forest Confections
Other Gift Ideas:
Snowflake stocking hanger, $41, Sign of the Arrow
Reindeer stocking hanger, $41, Sign of the Arrow
B. Marie stockings, $45 each, Sign of the Arrow
Picture frame, $16, Sign of the Arrow
St. Louis ornament, $38, Sign of the Arrow
Ted Baker chocolate leather gloves, $110, Nordstrom
New Era cap, $59, Nordstrom
Hugo Boss striped scarf, $65, Nordstrom


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Emerging Markets Evening Roundup: Yingli Looks To Boost LatAm Share; EEM May Benefit From Index Shift
The South African Municipal Workers' Union said some 200,000 workers will stop working later this week in protest of poor pay and corruption, adding to the the pressure to the country's economy which has been hit hard by wildcat strikes in the mining sector, the Associated Press reports.
President Vladimir Putin's allies won regional elections over the weekend, strengthening his hold on the country, even as allegations of fraud and voting abuse spread, WSJ's Gregory White writes.
Investors contemplating an IPO of Russian mobile phone operator OAO MegaFon are asking for a valuation of between $10 billion and $11 billion, Bloomberg's Ruth David, Ilya Khrennikov and Alexis Xydias report.
Argentina's growth could have been 4% this year, rather than nil, if it weren't for the country's investment-unfriendly policies, beyondbrics' Jude Webber writes.
Maybe LatAm will offer a buffer? Yingli Green Energy Holding Co. (YGE) shipped 40 megawatts of equipment to power projects in southern Peru as the firm tries to boost its share in the region at a time, Bloomberg's Stephan Nielsen writes. The move comes as many Chinese solar firms struggle with oversupply and weaker demand out of Europe.
In his column this week, colleague Brendan Conway explains why the iShares MSCI Emerging Markets Index fund (EEM) may benefit from Vanguard's decision to ditch the MSCI index for its Emerging Markets ETF (VWO). Investors in this part of the world have been grumbling at how none of the major indexes gives weight to some of the domestic demand type of companies they think are better suited for this current phase of development for emerging markets.


text:
Right now in the Philippines, people are picking up the pieces of their lives after typhoon Bopha swept through the country last week. They are scooping out mud from their damaged homes, assessing the cost of their flattened crops, and grieving for their dead.
At the UN climate conference in Doha last week, the Philippines representative made international headlines when he broke down while telling the story of his country. "As we sit here in these negotiations . . . the death toll is rising," he said. "I appeal to the whole world to open our eyes to the stark reality that we face."
Sadly, in the aftermath of Doha, Australians are not talking enough about the stark reality of our changing climate, and how weather-related disasters affect people's lives, particularly among our neighbours in the region.
Instead, the public debate has focused on perpetuating a number of myths about climate finance – the flow of funds from developed countries to help the world's poorest and most vulnerable nations adapt to climate change.
The first myth, as put forward by the Coalition, is that Australia has written a $3 billion blank cheque for poor countries, with no control over how or where that money will be spent.
While Australia's fair share of the global $US 100 billion committed to help poorer countries is indeed around 3 per cent, the funds will come from a mix of sources: both public and private.
And through its role as co-chair of the Green Climate Fund, a multilateral fund set up to make sure climate finance is managed effectively, efficiently and fairly, Australia is playing a leading role in making sure the funds have the greatest impact.
The notion that Australia has written a "$3 billion blank cheque" is therefore false, designed to mislead, and is a kick in the teeth for communities already bearing the brunt of climate change.
The second myth is that Australia must now compensate countries for "loss and damage" from climate impacts.
Vulnerable communities have been hit hard by shifting rain patterns, rising seas and increases in extreme weather are already suffering loss and damage, including to their land and livelihoods.
It's true that developing countries have contributed less than rich countries to rising greenhouse emissions, and a fair global climate deal will need to address the loss and damage they incur.
But comments this week suggesting Australian taxpayers are liable for a compensation fund on loss and damage are misleading.
It would be far better to stick to the facts, the things we know for certain.
The reality is that in Doha, countries decided to continue investigating ways of addressing the loss and damage suffered by developing countries, particularly those at most acute risk from climate change.
However, no decision has been made on any kind of compensation fund. A variety of options, including insurance schemes, are likely to be weighed over the coming months, with measures to be decided on at the next UN Climate Conference, to be held in Warsaw in late 2013.
Finally, the Coalition has described Australia's existing climate finance commitments as "an extraordinary amount of money".
Again, this is misleading and needs some context. Recent analysis by research group Oil Change International revealed Australia's climate finance is around one fortieth of the value of its fossil fuel subsidies.
In other words, our current commitments to helping poorer countries adapt and prepare for climate change are very modest compared to the continued financial support to emissions-intensive industries.
Climate finance is already a difficult topic to navigate. Spinning these kind of myths and creating confusion over what has already been agreed so far – and what has not – is an unhelpful distraction.
It would be far better to stick to the facts, the things we know for certain.
We know for a fact that climate finance helps vulnerable communities build greater resilience to future impacts of a warming world, protect people's land, lives and livelihoods, and reduce future reliance on emergency humanitarian assistance.
We know that action taken now to reduce global emissions will substantially reduce the challenges and costs we would otherwise face in the future.
And we know that threatening to backslide on existing commitments risks profoundly damaging the prospects for an effective global climate deal in 2015. This is one significant cost the world cannot afford.
Simon Bradshaw, climate change policy adviser, Oxfam Australia.


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DALLAS, Aug. 3, 2012 /PRNewswire-USNewswire/ -- The Cancer Prevention and Research Institute of Texas (CPRIT) has awarded $48.2 million in new grants to investigators at UT Southwestern Medical Center to support cancer-related projects and to recruit pre-eminent cancer researchers.
These awards to UT Southwestern, made after a rigorous peer-review process, were part of $114 million allocated for 45 projects and scientific recruits at Texas-based academic institutions and private firms.
"Our scientists and clinicians are dedicated to the fight against cancer," said Dr. Daniel K. Podolsky, president of UT Southwestern. "These awards will allow our investigators, in many instances working closely with colleagues at other institutions, to pursue high-impact work that addresses the most important unanswered questions that will lead to better treatment and prevention."
CPRIT was established in 2007 after Texas voters approved a constitutional amendment that authorized the state to fund cancer and prevention programs. In this latest round of CPRIT grants, UT Southwestern received the most funding of any individual Texas institution.
The new grants include seven Multi-Investigator Research Awards five involving UTSW which allow "dream teams" of scientists handpicked from multiple academic institutions to work collaboratively on cancer research projects.
It also provides funding for 14 projects to expand access to critical cancer prevention programs across Texas. For instance, to broaden access to screening services, Dr. Samir Gupta, assistant professor of internal medicine and clinical sciences, was awarded $2.2 million in support of evidence-based colorectal cancer screening for the uninsured.
A total of $19 million also was awarded for the recruitment of cancer investigators for multiple-site projects at UT Southwestern and other institutions.
With this round of funding, a total of 429 grants to date have been recommended by CPRIT's peer-review experts, presented to the institute's 11-member board, and then approved. Over three years of operations, all grants recommended to the Oversight Committee have been funded.
"This latest CPRIT decision recognizes UT Southwestern researchers for top-flight investigations in prostate cancer, childhood sarcoma, and stereotactic radiation. It also provides us with two program grants that build on our science to discover novel cancer therapeutics," said Dr. James Willson, director of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. "The latest grants are another bold step forward in attacking the disease, and will accelerate cancer research here."
Among the grants awarded to UT Southwestern researchers were:
One of the highlights is a collaborative effort among UT Southwestern, UT Health Science Center at San Antonio, and Baylor College of Medicine aimed at identifying and tracking genetic changes, as they occur in real time, in sarcoma patients across Texas.
Additionally, 20 CPRIT Scholar in Cancer Research awards designed to attract leading cancer scientists to Texas were funded.
Since its creation, CPRIT has awarded $760 million in grants. UT Southwestern has received 91 awards totaling $173.5 million.
Visit http://www.utsouthwestern.org/cancercenter to learn more about clinical services at UT Southwestern for cancers. More information about CPRIT is available at www.cprit.state.tx.us.
This news release is available on our World Wide Web home page at http://www.utsouthwestern.edu/home/news/index.html
To automatically receive news releases from UT Southwestern via email, subscribe at www.utsouthwestern.edu/receivenews
SOURCE UT Southwestern Medical Center


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Enochian wrote:Ok let me put it in another way.
If you 100% NEED a transmission to understand your natural state, it would NOT be natural would it?
Okay you are using natural state in its literal form. According to Atiyoga, your deluded habit of grasping is your unnatural state, because the samsaric mode is distorted. The natural state is like the background that a samsaric consciousness by def can't notice. The teacher is a relic of the natural state, a nirmanakaya, and the manner of pointing is samboghakaya, then you seeing what is pointed at is dharmakaya Samantabhadra the natural state free of distortion. Do you agree with this?


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Filmmaker George Lucas and longtime partner Mellody Hobson were married at Skywalker Ranch in a moving ceremony officiated by journalist Bill Moyers.
Although reports of the wedding on Saturday circulated over the weekend, details were first reported by the Huffington Post; founder Arianna Huffington is a friend of Hobson's.
"It only takes one person to have met the love of your life," Moyers told the bride and groom, the Post reported.
The Huffington Post added that former New Jersey Sen. Bill Bradley, a friend of Hobson's, gave her away, and Lucas collaborator Steven Spielberg gave a toast from the groom's side, joking that the Force finally had a name: Mellody. Francis Ford Coppola read a poem by Maya Angelou.
Van Morrison performed on the Skywalker Ranch stage and Janelle Monae performed as well.
"The wedding was beautiful," Lucas spokeswoman Lynne Hale said. "It was a gathering of people who have known George and Mellody for a very long time. It was an extraordinary day filled with so much love."
Hale added: "To have Bill Moyers who has such a long history with George officiate the ceremony and Bill Bradley who has known Mellody since she was 17 walk her down the aisle touched everyone's heart."
The 44-year-old Hobson wore a white dress by Peter Soronen. Lucas, 69, was married once before, to film editor Marcia Griffin.
Ron Howard tweeted, "George Lucas Melody Hobson wedding was joy to behold. Bill Moyers service was beautiful, nothing short of profound."
Hobson heads Ariel Investments and serves as chairwoman of Dreamworks Animation.
Contact Nels Johnson via email at firstname.lastname@example.com. Follow him at twitter.com/nelsjohnsonnews


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The Regnum Christi Movement offers its members some guidelines of a gospel-based spirituality as an ideal of Christian life. The spiritual path that Regnum Christi members walk mainly consists in knowing, loving, imitating, and proclaiming Christ. This is the path and these are the goals.
Below, we offer some resources that can help nurture the spiritual life of Movement members and of any Christian.
Daily Prayer 2013-10-25
Listen to podcast version here.
Father Steven Reilly, LC
Luke 12:54-59
Jesus said to the crowds, "When
you see a cloud rising in the west you
say immediately that it is going to rain -- and
so it does; and when you notice that the
wind is blowing from the south you say that
it is going to be hot -- and so it
is. You hypocrites! You know how to interpret the
appearance of the earth and the sky; why do you
not know how to interpret the present time? Why
do you not judge for yourselves what is right?
If you are to go with your opponent before a
magistrate, make an effort to settle the matter on
the way; otherwise your opponent will turn you over to
the judge, and the judge hand you over to
the constable, and the constable throw you into prison.
I say to you, you will not be released until
you have paid the last penny."
Introductory Prayer:
Lord, I believe that you are here with me.
I have come to honor and adore you. Your
love sustains me. I want to love you more in
Petition: Lord, allow me to
comprehend your providence more deeply.
1. Seeing
Signs: Jesus expresses some indignation with the spiritual obtuseness
of his listeners; in other words, they don't get
it! When it comes to earthly matters, they can put
two and two together in an almost infallible manner.
A dim dullness, however, has the upper hand when
the spiritual realm is broached. Why? Possibly because they
were not bothering to ponder what the sign of Jesus'
presence, miracles and words really meant. They remained on
the superficial level without plumbing the depths. Superficiality inhibits
our own spiritual progress as well. Seeing signs isn't
so much a matter of being able to pick out
the shape of a tabernacle or cross in a
passing cloud, but of deep and prayerful consideration of
the love of God in our lives.
2. God's
Presence: People who live a life of consistent prayer
are much more in tune with God's presence. Where
others see coincidence, they see providence. This gives them a
profound sense of peace. They know that God is
in charge and that they don't have to figure
out everything for themselves. The world doesn't rest on their
shoulders, but on God's. So instead of complaining or
worrying, they live in an atmosphere of trust and
3. Paying Attention: God's providence guides all things.
We know this through faith and sometimes he sends
a sign to say, "Yes, I'm indeed here." Once
a Legionary priest was driving down the road in Virginia
and his thoughts were taken up with a difficulty
he was having with a particular person. "How should
I handle this," he asked himself. A car pulled out
in front of him. Virginia is known for its
high number of vanity license plates, and this one
left him scratching his head. The license plate read "CARITAS",
which is Latin for "charity." Was it just a
coincidence? He couldn't deny that this was the answer
he was looking for. The signs that invite us to
be more Christ-like are the ones to which we
need to pay the most attention.
with Christ: Lord, the times I really don't pick up
on the signs you send me are when they
challenge my resistance to your grace. Help me to overcome
my spiritual superficiality and perceive your presence in my
Resolution: I will try
to be prompt in following the inspirations of the Holy
The daily meditation is a service of Regnum Christi that offers people a Gospel reflection through e-mail. You can view the weekly meditation on this link or listen the podcast version here.
If you would like to subscribe or send a gift subscription, please fill out this form.


text:
Former county water board member Steve Collins told an investigator it was his job to "broker" the regional desalination project when he worked for a private consulting firm on the now-failed proposal.
During a preliminary hearing Tuesday on conflict of interest and other charges against Collins, prosecutor Stephanie Hulsey played an interview with Collins in which he described his role in helping the proposal's partners work through key issues at the heart of the project agreements. Those agreements had been stalled by an often rancorous relationship among California American Water, the Marina Coast Water District and the county Water Resources Agency.
Testimony and evidence introduced at the all-day hearing indicated Collins was involved in nearly every aspect of the project through most of 2010, from fashioning a financing plan and seeking low-cost public funding to advocating for the project before local and state officials.
Collins' efforts represented a conflict of interest, prosecutors say. He had a financial stake in the project agreements, being paid more than $160,000 by RMC Water and Environment, which was employed by Marina Coast, for the work he did on the project while he was a public official — a prohibited dual role.
Collins is facing more than three dozen felony charges for allegedly accepting payments he wasn't entitled to receive or hadn't earned. In addition to being paid by RMC, Collins allegedly accepted money from his former employer, Ocean Mist Farms, for public meetings.
But defense attorney Mike Lawrence indicated during Tuesday's hearing that he would argue Collins was asked to take the lead on closing the project and was assured by county officials and legal counsel that his dual role was not a conflict.
Lawrence said his client's efforts benefitted everyone involved and thus shouldn't be considered a crime. He said it was only a "lapse of memory" by county officials that left Collins facing charges.
Deal with RMC
Hulsey laid out the case against Collins, introducing invoices detailing his efforts on behalf of the project, and his agreement with RMC. Company principal Lyndel Melton told an investigator RMC paid Collins $220 an hour to help resolve Ag Land Trust litigation challenging the project's environmental review and to bring the project partners together to smooth the way at the state Public Utilities Commission.
The original pact between Collins and RMC began in January 2010. It was only supposed to be worth $25,000 and last about three months, but its value expanded along with Collins' efforts and his advocacy as the project was delayed until late in 2010, according to testimony.
At one point, according to an investigator, Collins began actively defending the project agreements against questions from the PUC's Division of Ratepayer Advocates and the Monterey Peninsula Water Management District. Evidence suggested Collins urged county supervisors and the PUC to approve key agreements while arguing that each had insisted on proceeding.
Marina Coast general manager Jim Heitzman told an investigator he eventually realized Collins' work had expanded in what he called "scope creep," and he began expressing concerns about a potential conflict. That sparked a debate in June 2010 involving county and Marina Coast officials and legal counsel over whether a legal conflict existed.
Heitzman told the investigator he finally refused to continue paying the RMC bills after Collins failed to resign from the county water board and no legal opinion immediately materialized.
Later, Collins asked Cal Am President Rob MacLean for help getting paid for the work he did on the project, offered his services to Cal Am and even billed the county for his efforts, according to testimony.
According to the investigator, RMC's Melton said Collins and former county water agency general manager Curtis Weeks told him they had plans to work on the regional project through their own private consulting firm, Collins-Weeks Consulting.
When Salinas Valley Water Coalition consultant Nancy Isakson discovered Collins' dual role and raised questions about it, the investigator testified Isakson told her Collins first tried to convince her there was no conflict and then threatened her and the coalition.
Legal advice
During cross-examination, Lawrence focused on legal advice — or the lack of it — that Collins received, including the debate over whether his work represented a potential conflict and which officials knew what and when regarding the issue.
Lawrence pointed out that County Counsel Charles McKee acknowledged in a letter to the coalition that Collins had been "misadvised" by Deputy County Counsel Irv Grant, the county water agency's assigned counsel during the bulk of the project proceedings, and that attorneys from county-hired Downey Brand indicated they believed there was no conflict or produced a legal opinion that was open to interpretation.
Lawrence also focused on clear differences between the recollections of various public officials, including Weeks and Heitzman, about how Collins was recruited and the scope of his duties.
Lawrence suggested during questioning that Collins' work on the project couldn't reasonably be considered part of regular county water board member duties, especially as defined by the Agency Act, and that his client was simply performing a valuable service intended to benefit all area interests by securing a new water supply and avoiding an "extreme crisis on the Monterey Peninsula."
The hearing will continue at 9 a.m. Thursday.


text:
This has been posted a couple of times over in the big giant thread but I want to make sure that this gets out there for all to see.
In my opinion this is about perfect as far as response goes from the club.
Statement from Indiana Pacers President of Basketball Operations Larry Bird:
The news of Lance Stephensons arrest is very disappointing to the Pacers franchise and to me personally. We have worked very hard to bring in players that are excellent representatives of our franchise, community and state both on and off the court. Our commitment to this goal is too strong to permit the actions of one individual to reverse all of the positive strides that have been made as a franchise over the last couple of years or to hurt the image of the rest of the players on our team. Everyone in the Pacers organization remains strongly committed to our players representing Indianapolis and the state of Indiana in a positive way and will not condone behavior that reflects poorly on this franchise and community.
We are continuing to gather all of the facts regarding Lances arrest but regardless of the outcome of the investigation, Lance should not have put himself in the position he was in early Sunday morning. We have consistently emphasized to our players the importance of not putting themselves in situations where bad things can happen. Once all the facts are known we will deal appropriately with Lance so that he, the team and the entire Pacers community understands that this message cannot be ignored


text:
Nick Cannon's Open Letter to Amanda Bynes: "You're Not Alone. I'm Here For You" - In Touch Weekly
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Nick Cannon's Open Letter to Amanda Bynes: "You're Not Alone. I'm Here For You"
Updated: Feb 5, 2014 8:14 pm
In Touch Weekly
Pin it
Over the past few years, the world has witnessed
Amanda Bynes'
life go on a tailspin, spiraling out of control. Yesterday in a touching open
to the troubled 27-year-old actress,
Nick Cannon
offers his old friend his love and support through these difficult times.
Nick Cannon Reached Out to Amanda Bynes, Says He's Praying for Her
In his letter, the
America's Got Talent
host, 32, voices his support for his former costar and gives personal insight to the pitfalls of fame.
"Imagine being the breadwinner in your household before you can even drive. Imagine you parents, teachers, and employers NEVER telling you NO. Anything you ask for or want, the world gives you, at some point you are bound to self-destruct. I call this "access to excess." I've seen it happen to many of my friends and colleagues young and old. It goes back to that old saying; "Too much of anything is bad for anyone." Whether it's fame, money, sex, drugs, attention. It's all a dangerous addiction," he writes, adding,"When there is no balance in your life a person will always become victim to their reality or lack thereof. The question is, when this destruction occurs, who is there to help put back the pieces."
Amanda is currently being held under a 5150 involuntary psychiatric hold in Ventura, California, after being arrested for starting a fire in a residential driveway.
Amanda Bynes' Involuntary Psychiatric Hold Extended As Parents Seek Conservatorship
She and Nick met over a decade ago when they worked together on the hit Nickelodeon TV show
All That
. The two had remained close friends and Nick even considers her family.
"So I say to my sister Amanda Bynes you're not alone. I'm here for you. I understand. I care and I appreciate you, because that's what family does and that's what family is for. "
Earlier this week, Nick spoke exclusively to
In Touch
about Amanda and had nothing but inspirational things to say about her.
"We're just praying for her and hoping for the best," Nick revealed while at the IAMS So Good! event in NYC. "When someone's going through something like this, all you can do is be there for them."
After talking to
In Touch
, Nick went home to pen the letter to Amanda, which can be viewed in full
EXCLUSIVE: Homeowner Speaks Out on Amanda Bynes Setting Fire to Her Driveway: "I Think She Was High on Something"
What do you think of Nick's letter? Sound off in the comments section below!
Pin it
Every Blac Chyna Reference You Ever Heard Before You Even Knew Who She Was
Nick Cannon Will Not Be Returning to Host 'AGT' — Find out Why!
Beyoncé Named Her Twins Rumi and Sir, but What the 'Eff Do They Mean? Weird Celebrity Baby Names Explained!
Love Isn't Always Forever — Just Ask These Celebrities Who Got Their Tattoos Covered Up


text:
Gardening and nutrition education for youth is vital to cultivating healthy kids and healthy communities. In addition to adult gardening classes, Urban Harvest has an extensive Youth Education program. We offer advice, education and services to provide parents, teachers and administrators with information to build and maintain a successful and sustainable school garden program.
Urban Harvest also has school partnerships to develop outdoor classrooms including programming with an Urban Harvest garden educator and project management. Garden education programs are delivered after school or during school to enrich curriculum. Standard subjects include social studies, math, science and language arts. In addition, we explore nutrition, food systems and native habitats and ecosystems at elementary and middle schools in the Houston and Spring Branch ISDs.
Volunteer times for the Urban Harvest Teaching Garden
Thursdays, 9:00 - 11:00am at Gregory-Lincoln Education Center 1101 Taft St, Houston, TX 77019
This is a great volunteer activity for parents and their school-age children, teens looking for community service hours & neighbors who want to improve their "hands on" gardening skill! Activities include cultivating, planting & harvesting. Individual volunteers are welcome to show up during hours listed.
Please wear closed toe shoes, long pants, hat and bring a reusable water bottle.
To volunteer with groups of five or more, please email our volunteer coordinator or call 713.880.5540.
See tips in how to Rescue Your Garden From Water Logged Soils.


text:
Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Human papillomavirus (HPV-16) is an important factor in the development of many tonsil and/or base of tongue squamous cell cancers. Although HPV-16 is not thought to cause cancer by itself, it appears to contribute to the development of tonsil and/or base of tongue cancer in many patients. It is likely that treatment for many patients with tonsil and/or base of tongue cancer could be improved if effective therapy to control HPV-16 is developed. The investigators in this study want to learn if ribavirin shows evidence of activity against HPV-16.
Ribavirin is a pill therapy that is approved by the Food and Drug Administration (FDA) as part of the standard treatment for Hepatitis C. Laboratory experiments suggest that ribavirin might also be useful in the treatment of head and neck cancers. However, ribavirin has not yet been tested against head and neck cancer in patients. The purpose of this study is to find out the effects of ribavirin on tonsil and base tongue squamous cell cancer in patients.
The main purpose of this study is to see if ribavirin changes the expression of certain proteins related to HPV infection in the tumor. The study will also find out if ribavirin changes how the tumor appears in a PET/CT scan (positron emission tomography/computed tomography scan).
|HEAD & NECK Cancer
|Drug: ribavirin
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma
- To explore if ribavirin therapy for 2 weeks decreases tumor expression [ Time Frame: 2 weeks ]of phosphorylated eIF4E among patients with tonsillar squamous cell carcinoma.
- to explore the pharmacodynamic effects of ribavirin [ Time Frame: pre-treatment and post treatment ]on molecules that may be regulated directly or indirectly by eIF4E (eg, p16, p21, EGFR, p53).). Immunohistochemistry will be performed on Pathology samples (e.g. diagnostic biopsy), as well as on the post-treatment surgical pathology samples (e.g. definitive surgery),to describe the effects of ribavirin treatment on the expression of phosphorylated eIF4E.
- To explore if ribavirin reduces the expression of HPV-16 oncoproteins E6 and E7 [ Time Frame: In pre- and post-treatment tumor samples ]Pathology samples (e.g. diagnostic biopsy), as well as on the post-treatment surgical pathology samples (e.g. definitive surgery)
|Estimated Enrollment:
|Study Start Date:
|December 2010
|Estimated Study Completion Date:
|December 2017
|Estimated Primary Completion Date:
|December 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: ribavirin
This will be a single institution non-randomized study for patients with tonsil and/or base of tongue squamous cell cancer. This is a pilot study to obtain pharmacodynamic data regarding the effects of ribavirin on tonsil squamous cell cancer.
Drug: ribavirin
The clinical intervention in this study is ribavirin therapy for approximately 14 days. Ribavirin 800 mg/day is administered in divided doses, 400 mg PO qAM and 400 mg PO qPM.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Prior diagnostic surgical or core needle biopsy, with confirmation of tonsil and/or base of tongue squamous cell carcinoma that is positive for expression of p16 and phosphorylated eIF4E, as determined by the Department of Pathology at MSKCC. The biopsy may be either of the tonsil base of tongue and/or an involved neck node. 2 unstained slides and/or tissue block must be available from the initial diagnostic biopsy
- Positive expression p16 and phosphorylated eIF4E is defined as >=30% of tumor cells with cytological and/or nuclear staining
- Age ≥ 18 and ≤ 65 years of age
- Karnofsky Performance Status ≥ 80
- Adequate organ function, as follows:
Adequate bone marrow reserve: absolute neutrophil count (ANC) ≥ 1.5 X 109/L, platelets ≥ 160 X 109/L, hemoglobin ≥ 12 g/dL Hepatic: total bilirubin within 1.5 X upper limit of normal (ULN) ; alkaline phosphatase (AP), aspartate transaminase (AST) and alanine transaminase (ALT) ≤ 2.5 X ULN (Patients with Gilbert's syndrome as the cause of hyperbilirubinemia may be eligible if total bilirubin ≤ 2.5 X UNL) Renal: Serum creatinine ≤ 1.3 mg/dL. Patients with serum creatinine > 1.3 mg/dL may be eligible if creatinine clearance (CrCl) ≥ 55 mL/min based on the standard Cockroft and Gault formula.
- Patients of childbearing potential must have a negative serum pregnancy test within 14 days of treatment. Patients must agree to use a reliable method of birth control during and for 6 months following the last dose of study drug.
- Ability to swallow oral medication.
- Non-surgical patients: If primary radiation +/- chemotherapy (concurrent or sequential) is planned, patients must agree to undergo research biopsy after completion of ribavirin treatment.
Exclusion Criteria:
- Prior chemotherapy or radiation for tonsillar or base of tongue squamous cell cancer
- More than 10 pack-years of tobacco use
- History of hemolytic anemia or thalassemia
- Active infection or serious underlying medical condition that would impair the patient's ability to receive protocol treatment.
- Current therapeutic anticoagulation with Coumadin (warfarin)
- Current or prior treatment with ribavirin
- Known active Hepatitis B or C
- Any prior documented history of transient ischemic attack (TIA) or cerebrovascular accident (CVA)
- New York Heart Association (NYHA) Grade II or greater congestive heart failure
- Clinically significant peripheral vascular disease
- History of unstable angina or myocardial infarction (MI) within the last 3 years
Please refer to this study by its ClinicalTrials.gov identifier: NCT01268579
|United States, New York
|Memorial Sloan Kettering Cancer Center
|New York, New York, United States, 10065
|Principal Investigator:
|David Pfisher, MD
|Memorial Sloan Kettering Cancer Center
Additional Information:
|Responsible Party:
|Memorial Sloan Kettering Cancer Center
|ClinicalTrials.gov Identifier:
|NCT01268579 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 29, 2010
|Last Updated:
|January 4, 2017
Keywords provided by Memorial Sloan Kettering Cancer Center:
base of tongue
squamous cell carcinoma
Additional relevant MeSH terms:
Carcinoma, Squamous Cell
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms, Squamous Cell
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
Snow PlowRiddles are little poems or phrases that pose a question that needs answering. Riddles frequently rhyme, but this is not a requirement.
The following limerick has had the last word of each line scrambled. Can you figure it out?
In a snowstorm the plow wasn't TWIFS,
So Jim was decidedly FIDFEM;
His street really ENDEDE
The plow, so he DAPELED,
But the driver did not get his FIDTR.
AnswerIn a snowstorm the plow wasn't SWIFT,
So Jim was decidedly MIFFED;
His street really NEEDED
The plow, so he PLEADED,
But the driver did not get his DRIFT.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this riddle, keep track of
which ones you have seen, and even make your own.
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text:
With T-Mobile trailblazing, Verizon CEO sees the end of phone subsidies as a 'great thing'
36 Comments
1. downphoenix (Posts: 3165; Member since: 19 Jun 2010)
I'd be willing. I like having to not pay a lot for a phone, but at the same time, Im all for consumers buying something within THEIR budget as opposed to getting conned by carriers.
13. metalpoet (unregistered)
I hate spending $200-$300 plus the stupid upgrade fee of $30 for a phone so why would I want to spend $400-$600 for a phone? Plus my company will simply pull out of the mobile market altogether because very few Utahns are willing to spend even $200 for the latest and greatest devices, bunch of f***ing couponers! :( I hope they allow people the option to do one plan or the other with the phone cost.
24. gwuhua1984 (Posts: 1237; Member since: 06 Mar 2012)
I think once the subsidies ends, the plan price and phone prices will drop. Carriers will battle between themselves on network and pricing. Phone manufacturers will battle themselves on specs and pricing of their phones. For each market, the 2 things for each of them are what matters most to consumers.
26. Imbatman (Posts: 10; Member since: 07 Jan 2013)
you understand that there are countless countries that dont subsudized devices. Hell, Korea just recently Fined 3 of its companies for doing so in their home country. So why would the prices of devices drop if just the us stops subsudizing? People wont stop buying phones, they will still do so and the profit will just keep rising.
27. CRICKETownz (Posts: 980; Member since: 24 Oct 2009)
the only problem w/that theory is that when you have large group of people accustomed to what is considered "reasonable pricing" on equipment now being exposed to $400-$500 pricing there is going to be instant backlash. the mindset of people in the US is i want the best for the least amount of money. the amount of people coming asking for a free phone grows daily esp. when you have outlets like Sam's Club, Best Buy Mobile, Target etc. offering phones for $0.97...that won't go over well. it may be normal outside of the states but to take away the subsidy is going to mark the rise of the basic phone & the decline of smart phones.
37. metalpoet (unregistered)
CRICKETOWNZ: You have a point buddy, I know for a fact that I'll be out of a job as well as my employees if they start jacking up the prices of phones because ppl will simply go on ebay, newegg, and amazon.com to buy phones instead of coming in to brick and morter stores, thus eliminating hundreds of thousands of jobs in the wireless industry.
2. gwuhua1984 (Posts: 1237; Member since: 06 Mar 2012)
Screw phones with carrier branding... not to mention delay of phone updates and bunch of other crap. I'm all for the end of phone subsidies.
6. NexusKoolaid (Posts: 493; Member since: 24 Oct 2011)
Amen. I haven't had a subsidized phone since the Nexus One. No carrier bloatware. No OS modifications or any bugs they happen to introduce. And yes, faster updates.
8. gwuhua1984 (Posts: 1237; Member since: 06 Mar 2012)
Perhaps it'll also bring an end to carrier exclusive devices.
15. metalpoet (unregistered)
Now that i can get on board! im sick of Verizon being the ONLY thing that works in my area and they have the ugliest devices!
31. Mittal (Posts: 494; Member since: 14 Dec 2011)
But i have a question...
Dont the consumers in the US have a choice to buy an unlocked phone off contract and choose any carrier and a cheap plan ?
33. TheMan (Posts: 494; Member since: 21 Sep 2012)
Americans can buy a phone at full price, thereby avoiding a contract BUT: 1. This option, while available online is rarely mentioned at any point of sale, advertisement, etc.; 2. Monthly rates for the unsubsidized buy are typically the same as the subsidized one; 3 The carriers themselves are the primary source of phones and often the point of differentiation, branded and locked for use on that carrier.
Many (most?) Americans wouldn't know where to turn for an unlocked options, which may not work on all carriers.
35. Mittal (Posts: 494; Member since: 14 Dec 2011)
Thanks for the reply
"Monthly rates for the unsubsidized buy are typically the same as the subsidized one" If thats true then thats total bulls**t, almost extortion!
Yes and as u mentioned, many international versions may not be compatible with some 3G/4G network of some carrier which again puts the consumer in a confused state....
These seem to be bad practices being followed in the US
36. TheMan (Posts: 494; Member since: 21 Sep 2012)
No argument here. T-Mobile US first tried to price service 3-4 years ago at a lower rate for full-price mobile purchases, but the oligopoly of Verizon-AT&T-Sprint have yet to adopt.
Carrier control of handsets helps contribute to the U.S. having the highest service rates in the world (Canada's #2). I don't see that changing any time soon, sad to say.
3. MartyK (Posts: 962; Member since: 11 Apr 2012)
Instead of locking you into a 2 years contract, break payments into 6 month chunks; this will work better for everyone.
And for added security for the carrier, warehouse (Red list) all phones that was not pay-in-full.
18. phoenixpr (Posts: 167; Member since: 28 Mar 2012)
Agree! or I believe people will be willing to purchase the phone full price and not have it subsidies. If it's a phone that can be taken on to any carrier. But to pay full price and then hate the carrier. Then trying to regain your money back on eCrap (eBay) is a waste of my time. I would gladly pay $400 -$800. It's like buy a $4000 TV in NYC, then moving to California and TV isn't compatible with the cable company in the west coast. Make a phone that works on all carrier. Have an app that on the phone that I can chose what ver carrier to activate. We can put a man on the moon, we can do this.
4. jcpwn2004 (Posts: 314; Member since: 18 Jan 2012)
I'd be all for it, carriers are afraid because then they would have to compete on plans instead of being able to hide the phone costs in 100$/mo bills.
5. Jyakotu (Posts: 855; Member since: 12 Dec 2008)
There are plenty of prepaid options and even if you want to stay with a Big 4 carrier, most of them have prepaid options as well, which require you to pay for the phone upfront anyway. Still, I don't know if I'd pay $300+ for a cell phone. Sure, the monthly plan would be cheaper in the long run, however, with phones constantly updating and changing, it's kind of hard to spend that kind of money on a device unless you knew for sure it was going to be supported by the OEM.
7. torr310 (Posts: 1124; Member since: 27 Oct 2011)
So that means T-Mobile is doing the right thing.
I hate the limited handset choices and bloatwares/slow update of the subsidized phones.
10. akhi216 (Posts: 61; Member since: 01 May 2011)
It should pave the way for carriers allowing people who have good credit to pay unsubsidized prices for phones in installments, which should have happened in the first place to help keep monthly fees down.
16. Larry_ThaGr81 (Posts: 452; Member since: 26 May 2011)
That still will hurt their profits because all the consumers out their that don't have good credit won't be able to buy smartphones and tablets with monthly installments.
11. Larry_ThaGr81 (Posts: 452; Member since: 26 May 2011)
No, we the consumers should be asking all the carriers who choose to adopt this plan are they ready to see the products sales to a severe drop due to people being unable to afford these over priced smartphones and tablets. Let's face it, all the carriers will still overcharge for the phone because they want to make a profit on the products themselves and they will try to make up for the lack of product sales. Do the carriers want to loose the ability to keep consumers locked into two year contracts because we all know that the carriers make more money on a two year contract agreement over two years than it would cost to buy the phone out right.
14. Larry_ThaGr81 (Posts: 452; Member since: 26 May 2011)
If that's suppose to be a threat from Verizon CEO that they would like to see subsidies go, then they are shooting themselves in the foot and really opening up the door for people to jump ship as soon as Verizon does something that puts consumers at a disadvantage, which is becoming a common theme for them.
28. CRICKETownz (Posts: 980; Member since: 24 Oct 2009)
actually carriers would much rather you buy the phones outright instead of taking the subsidized pricing b/c that is straight revenue that they don't have to recoup from losing money on selling you a $650 for $200. if you're paying what they are paying for the phones (which they don't have to worry about making up the cost since you paid it) plus getting the monthly service from you that is a carrier's fantasy. it takes most carriers months of you paying for a service to start making the money up that they lost so if you just buy the phone that means the company starts making money from day one. your theory is backwards. the only thing there is a greater risk factor involved b/c that customer isn't under contract so the door is always open for them to leave.
12. Larry_ThaGr81 (Posts: 452; Member since: 26 May 2011)
Take Verizon for example 1 smartphone line nowadays would cost a miniumum of $70 per month excluding taxes over the course of 24 months, which adds up to $1680. The $70 dollars comes from their current pricing structure at $40 for the smartphone and $30 for 2GB of data.
17. phoenixpr (Posts: 167; Member since: 28 Mar 2012)
You all have it WRONG, I believe people will be willing to purchase the phone full price and not have it subsidies. If it's a phone that can be taken on to any carrier. But to pay full price and then hate the carrier. Then trying to regain your money back on eCrap (eBay) is a waste of my time. I would gladly pay $400 -$800. It's like buy a $4000 TV in NYC, then moving to California and TV isn't compatible with the cable company in the west coast. Make a phone that works on all carrier. Have an app that on the phone that I can chose what ver carrier to activate. We can put a man on the moon, we can do this.
19. Larry_ThaGr81 (Posts: 452; Member since: 26 May 2011)
Hell I'd pay full price with the understanding that I can take my phone to any carrier, but again not everyone has the means to be able to do that.
32. Mittal (Posts: 494; Member since: 14 Dec 2011)
i beleive so too buddy !!
Here in India, That is exactly the way it happens. Any GSM device runs on all carriers and we r not bound by any contracts. Its swell!!
20. Larry_ThaGr81 (Posts: 452; Member since: 26 May 2011)
The vast majority of phone carrier consumers are under contract now when they've always had the option of buying the phone at full retail and avoiding being locked into a contract. If people could afford full retail prices, I'm sure the idea of not being locked into a two contract alone would have been enough for many people to pay full price.
21. roscuthiii (Posts: 2272; Member since: 18 Jul 2010)
If Big Red's CEO is for it, then I'm certain this whole unsubsidized thing means just that. Unsubsidized... you pay the total cost up front. However, I don't think it would be exactly like buying an unlocked phone.


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Los Angeles Archdiocese kept sexual abuse in the shadows » Monsignor Benjamin Hawkes
After washing his hands and asking the Lord to cleanse him of his sins, Monsignor Benjamin Hawkes turned to an altar boy and winked.
Hawkes would do this during Sunday Mass, just before serving Holy Communion.
"It would always make me feel very uncomfortable," the altar boy said in a deposition more than 30 years after serving with Hawkes at St. Basil's Catholic Church in L.A.
"Here was this priest saying mass who is grabbing my penis and telling me that he wants the Lord to wash away his iniquities."
But the altar boy at that time felt he could tell no one.
In his two-decade long reign as one of the city's most powerful men, Hawkes built the Archdiocese of Los Angeles into one of the wealthiest in the nation with a tough, some said ruthless, style. He even served as a model for Robert DeNiro's commanding monsignor in the 1981 film "True Confessions."
Hawkes saved the archdiocese from debt by selling off property he considered unnecessary, then growing the schools and hospitals. He sat on several boards and commissions within the diocese, was the secretary of two archbishops who later became cardinals and served as administrative officer and treasurer until Roger Mahony became archbishop in 1985.
Hawkes was untouchable, but according to a deposition and handwritten letter, the old priest liked to touch boys. An accuser who said he was abused by Hawkes from between age 12 and 24 emerged years later. A member of a poor immigrant family from Ecuador, the accuser had became an altar boy at St. Basil's. The controlling priest manipulated the family into enrolling their son in Catholic school.
His adopted brother also was molested by the monsignor, according to the deposition.
In a handwritten letter in the court records, dated May 14, 2002, to Cardinal Mahony, the accuser called Hawkes a "slick operator."
"During the High School years the abuse was physical, sexual and mental," the accuser wrote. "Msgr. was able to isolate me to the point that I could not turn to anyone for help. When I tried telling my parents by saying that Msgr. was harsh and mean, they would say that it was for my own good and that he was helping our family."
The accuser said Hawkes molested others, including boys from France and Mexico who stayed at the church during summertime.
"I know he sexually abused them because they told me," the accuser wrote. "I would not do anything, except to tell them to lock the door at night and pretend not to hear him knocking. They were lucky because the visit was only for short periods."
"Why didn't someone help us?" the accuser asks in the letter. "I believe this whole ugly thing could have been stopped if someone had the will to stop it."
Hawkes died in 1985, weeks after resigning from his post.


text:
SU student proves value of internships
We always knew internships were important, but SU alumna Brooke Chatterton '14 conducted research on Career Services' data and discovered empirical proof of the value of internships. And she earned herself publication in the Huffington Post's "The Thesis Project" as an excellent example of undergraduate scholarship. Congratulations, Brooke!


text:
The man who fought against Simon Cowell and propelled Rage Against the Machine to Christmas number one has once again proved he is top of the pops.
Jon Morter, 38, of South Woodham Ferrers, used his social media skills to place the Justice Collective's Hillsborough charity single at the festive top spot, beating X Factor winner James Arthur.
The star-studded cover of He Ain't Heavy, He's My Brother, which features Paul McCartney, Mel C and Robbie Williams, sold over 269,000 copies to top the UK singles chart.
So far the single has raised approximately £130,000 towards the legal fees of the families of the 96 Liverpool fans who died in the Hillsborough disaster in 1989.
See this week's MBS for the full story.


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Posted 5 years ago
(1 item)
Mongomery Ward Diamond Phone Complete. Manufactured. Does anybody know about this phone? Like new There are 4 billion cell phones in use today. Many of them are in the hands of market vendors, rickshaw drivers, and others who've historically lacked access to education and opportunity. Information networks have become a great leveler, and we should use them together to help lift people out of poverty and give them a freedom from wan


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Could the tides be turning for the parched Plains? That's the question on many minds as a brewing storm in the west appears to be ready to target the dry region.
While the exact track and impact of the storm has yet to be determined, many models paint a bulls-eye on several key agricultural states, including Kansas and Nebraska, two of the driest states in the country.
Moisture, whether as snow or rain, has been scarce in the region with most storms bypassing the Plains. Last week's Drought Monitor report showed that 96 percent of Nebraska and 75 percent of Kansas is in extreme or worse drought.
While it's unlikely that the snow will eliminate the drought, any little bit will help. According to the National Weather Service (NWS), most of the Sunflower and Husker States reported just a trace of precipitation so far in 2013.
Days before the storm hits, models and forecasts pegged snowfall totals between 6 and 10 inches for areas from central Kansas into southern South Dakota. However, with so much time remaining before any precipitation from the storm begins to fall, changes to these totals will be expected. Overnight data will give forecasters a better look at accumulations on Wednesday.
Currently the storm should start affecting the Plains on Wednesday evening and linger into Thursday evening. In addition to snow, southern Kansas may see also see freezing rain and sleet.
Despite this, as of Tuesday afternoon, the NWS released Winter Weather Watches and warnings for all counties in both states. The Winter Weather Watches were also extended into South Dakota, Iowa, Missouri and Arkansas.
Agricultural meteorologists had even more good news on Tuesday. Reuters reports that another storm system is expected to bring rain and snow again to the region next week.
John Dee, meteorologist for Global Weather Monitoring, told Reuters that "this will really help add to soil moisture levels."
The next ten days may not quench the drought, but it will bring some relief to thirsty soil.
Read, "Dry Crop Belt counts on more than a drop of February rain."


text:
Plasma and Intracellular Concentrations of Raltegravir and Etravirine Administered Once Daily (RAET)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Hypothesis: the intracellular concentrations of raltegravir (RAL) and etravirine (ETV) administrated as 800 and 400 mg once a day, respectively, are similar to those obtained with the standard doses of 400 and 200 mg/12h, respectively.
Objective: To analyze the plasma and intracellular concentrations of RAL and ETV administrated as 800 and 400 mg once daily respectively compared with standard doses of 400 and 200 mg/12h, respectively, and if they support its once daily administration.
|HIV-1 Infection HIV Infections
|Drug: Raltegravir Drug: Etravirine
|Phase 4
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Plasma and Intracellular Concentrations of Raltegravir and Etravirine Administered Once Daily (800 mg and 400 mg, Respectively) Compared With Standard Dosing (400 mg and 200 mg/12 h) in Patients With HIV Infection
- Changes in pharmacokinetic parameters (Cmax, Cmin, AUC, t1/2, and Cl), both in plasma and intracellular, of RAL and ETV. [ Time Frame: baseline and 1 week ]
|Study Start Date:
|April 2010
|Study Completion Date:
|January 2011
|Primary Completion Date:
|October 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Raltegravir 400 mg bid
Drug: Raltegravir
Changing the dose of raltegravir from 400 mg bid to 800 mg qd
Etravirine 200 mg bid
Drug: Etravirine
Changing the dose of etravirine from 200 mg bid to 400 mg qd
Detailed Description:
Objective: To analyze the plasma and intracellular concentrations of RAL and ETV administrated as 800 and 400 mg once daily respectively compared with standard doses of 400 and 200 mg/12h, respectively, and if they support its once daily administration.
Method: Phase IV, prospective, open labelled clinical trial with a planned duration of 24 weeks in which 16 patients from Hospitales Universitarios Virgen del Rocío will be enrolled. A 12 hours pharmacokinetic profile (immediately before and after 1, 2, 3, 4, 6, 8, 10 and 12 h) will be obtained after a supervised drug intake while taking RAL or ETV bid. Afterwards,the patients will take RAL or ETV once a day for 7 - 10 days. Subsequently, a new pharmacokinetic profile (predose and after 1, 2, 3, 4, 6, 8, 10, 12, 16, 20 and 24 h after a supervised drug intake) will be obtained.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Adult HIV-1-infected patients taking raltegravir- or etravirine-based antiretroviral regimens
Exclusion Criteria:
- Pregnancy
- Concomitant use of drugs that have potential interactions with raltegravir or etravirine pharmacokinetics
- Cirrhosis with clinical or analytic data of liver failure.
- Clinical history suggesting malabsorption or presence of diarrhea (> 3 stools / day) that could interfere with the absorption of study drugs.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01121809
|Hospitales Universitarios Virgen del Rocio
|Sevilla, Spain, 41013
|Principal Investigator:
|Luis F Lopez-Cortes, ND, PhD
|Hospitales Universitarios Virgen del Rocío
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Luis Fernando Lopez-Cortes, Hospitales Universitarios Virgen del Rocío
|ClinicalTrials.gov Identifier:
|NCT01121809 History of Changes
|Other Study ID Numbers:
2009-014480-39 ( EudraCT Number )
|Study First Received:
|May 4, 2010
|Last Updated:
|February 7, 2011
Keywords provided by Hospitales Universitarios Virgen del Rocío:
Additional relevant MeSH terms:
Communicable Diseases
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
Raltegravir Potassium
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
HIV Integrase Inhibitors
Integrase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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LONG BEACH - If it weren't for the commercial airplanes visible through tall glass walls, travelers might mistake the new concourse at the Long Beach Airport for a resort hotel.
Visitors will now be greeted by stylish new decor including plush red seats, elongated fire pits and a garden walkway - part of a renovation officials showed off Wednesday.
The new concourse - which will feature two terminal buildings, 4,200 square feet of outdoor seating and more than 10,000 square feet of new retail and restaurant space for Long Beach merchants - is set to open to airline ticket holders next Wednesday.
The public will be able to check it out before the checkpoints are put in place Sunday (tour reservations are required).
"It's a community asset," Airport Executive Director Mario Rodriguez said in advance of the Wednesday evening unveiling that was attended by local dignitaries.
"It really is what we're trying to build here. It's their airport."
The $45 million terminal project - which is five months ahead of schedule and on budget - has been years in the making. The work was funded entirely through airport revenue.
The airport had already built a new parking garage as well as part of the modernization overhaul.
Several obstacles delayed the project, including a drawn-out battle over its size and how it could affect the quality of life of neighbors living under the flight path. A lawsuit by the Long Beach Parent Teacher Association claiming that the project would lead to more flights, in turn increasing noise and pollution, also slowed the renovation.
Also raising the stakes was JetBlue CEO Dave Barger's 2009 comment to an airline industry blogger about JetBlue pulling out of Long Beach because of the delays. The airline currently has 32 of Long Beach Airport's 41 flight slots.
JetBlue officials said this week they are delighted with the project's turnout.
"We think it will put Long Beach back on the customer service map," said Robert Land, a top JetBlue executive.
Long Beach Airport officials said they wanted to approach the project differently than other airports, including Los Angeles International Airport, which is in the midst of building the new Tom Bradley International Terminal.
Coincidentally, that terminal was supposed to open next Wednesday, but has been delayed in part due to weather.
Other projects are designed with 80 feet to 100 feet of ceiling space that, "unless you are a bird or a balloon, you really can't feel," Rodriguez said.
"We cut out all those things that are unnecessary and concentrated on things that deal specifically with the customer."
That included bringing in local vendors such as Polly's Coffee, Sweet Jill's Bakery, 4th Street Vine, George's Greek Cafe and second locations for Long Beach Clothing Co., which will be called 562 Experience, and McKenna's on the Bay, whose second restaurant will be named McKenna's on the Fly.
Gregg Paradies of The Paradies Shops, which has been operating the concessions at Long Beach Airport since 2005, said the move to have mainly local vendors is unusual in the industry.
"About 50 percent of your average airport program is locally branded," he said. "It's going to be unique and truly have a home feel for Long Beach when you get off that place. Airports in today's world are doing more of the localization because airports are the front door and back door to the city, the first impression and last impression."
That local approach, Rodriguez said, has also helped to keep the project cost-effective.
Instead of a lofty "Taj Mahal size" space with "Taj Mahal price tags," Rodriguez said, "We designed something that's comfortable, that feels more or less like a high-end hotel."
The new concourse has been generating a lot of interest from privatized airports in Europe and a couple of Chinese delegates, Rodriguez said.
"I think (the new concourse) will make it a model for other airports," said Roy Williams, an aviation expert and consultant. "I think Long Beach is going to set a good standard for ease and convenience with these amenities."
Those amenities are some of the things airports are now trying to offer, aviation expert Jack Keady said.
"Airports everywhere are trying to do this to please customers," offering things such as free Wi-Fi and massages, he said. "They are trying to enrich the customer experience because, let's face it, nobody is happy when they get on a plane and have to squeeze into a seat."
firstname.lastname@example.com, 562-714-2088, twitter.com/KarenMeeksPT


text:
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Reserve digital conversion equipment here (read instructions first).
To create a reservation you will need to log in with your BPL library card barcode and PIN below. View the schedule without logging in.


text:
The Oakland County Sheriff's Office has obtained a warrant for the man suspected of recently shooting a man and robbing him of his pants in Pontiac.
Frank Earl Tyson -- the suspect in the incident -- is believed to still be at large in the area.
Tyson, 36, is charged on six counts, including armed robbery, weapons and assault.
The incident in question began when Sheriff's deputies found a 39-year-old man partially undressed and bloodied Dec. 26 at a residence on the 100 block of Lull Street.
The man told officials he was robbed and shot in the hip by his girlfriend's ex-boyfriend, who deputies believe is Pontiac resident Tyson.
He took them to the scene of the robbery, a home on the 300 block of Wessen Street, where they found his vehicle and the clothes that he had been stripped of.
The man, a Waterford resident, said that Tyson attacked him from behind while he was visiting a friend.
The Waterford man sustained non-life-threatening injuries and was transported to McLaren Oakland Hospital for treatment.
Undersheriff Mike McCabe warned that Tyson is considered armed and dangerous.
"Residents should not approach him," said McCabe. "Instead, they should immediately call 911."
Crime Stoppers of Michigan is offering a cash reward, starting at $1,000, for tips leading to Tyson's arrest.
The Oakland County Sheriff's Office urges anyone with information regarding Tyson's whereabouts or information about the case to contact dispatch personnel at 248-858-4911 or Crime Stoppers at 1-800-SPEAK-UP.
Contact staff writer John Turk at 248-745-4613 or email@example.com.