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Not the biggest Sally Jenkins fan on the planet but this is an excellent piece.
Pat Summitt, Tennessee womens basketball coach, diagnosed with Alzheimers disease
By Sally Jenkins, Published: August 23
KNOXVILLE, Tenn. Pat Summitts doctors are lucky they are still standing. When the first neurologist told her she had symptoms of early-onset Alzheimers disease, she almost dropped him with one punch. When a second one advised her to retire immediately, she said, Do you have any idea who youre dealing with?
Three months ago, Summitt, 59, the blaze-eyed, clench-fisted University of Tennessee womens basketball coach who has won more games than any other college coach ever, mens or womens, visited the Mayo Clinic in Rochester, Minn. seeking an explanation for a troubling series of memory lapses over the past year. A woman who was always highly organized had to ask repeatedly what time a team meeting was scheduled for. She lost her keys three times a day instead of once, her son Tyler says. She was late to practice. On occasion, she simply stayed in bed.
Are you having trouble with your memory? friends began asking, puzzled.
Sometimes I draw blanks, Summitt finally admitted.
Her first clue that something was badly wrong came last season, when she drew a blank on what offensive set to call in the heat of a game.
I just felt something was different, she says. And at the time I didnt know what I was dealing with. Until I went to Mayo, I couldnt know for sure. But I can remember trying to coach and trying to figure out schemes and whatever and it just wasnt coming to me, like, I would typically say, Were gonna do this, and run that. And it probably caused me to second-guess.
Summitt believed her symptoms were the side effects of a powerful medication she was taking for rheumatoid arthritis, an excruciating condition that she has quietly suffered with since 2006. Instead, when Summitt received her test results from the Mayo Clinic at the end of May, they confirmed a shocking worst-case scenario: She showed mild but distinct signs of early-onset dementia, Alzheimers type, the irreversible brain disease that destroys recall and cognitive abilities over time, and that afflicts an estimated 5 million Americans.
Denial was followed by anger. For the first few weeks, Summitt would barely even discuss the subject. She told her doctors, You dont know me. You dont know what Im capable of. Finally, Summitt realized she would have to accept the diagnosis. I cant change it, she says. After a pause, she adds, But I can try to do something about it.
Last week Washington D.C. attorney Robert B. Barnett flew to Knoxville to meet with his longtime friend and client, half expecting her to step down after 38 years as Tennessees coach. But Summitt told Barnett that she did not believe her symptoms were severe enough yet to warrant retirement, and that she would like to coach at least three more years, if possible. She also decided against a formal statement. Instead, she sat down for an interview with this writer, who co-authored her 1999 autobiography, and the Knoxville News-Sentinel to discuss her illness publicly for the first time.
Full disclosure: It is the measure of Summitts large-heartedness that she could call any of a half-dozen people her closest friend. This writer has only one: her. I would rather drive stakes through my own hands than write this story, I said.
It is what it is, she said. Ive got to face it.
You will always be our coach
Last Thursday, Summitt, Barnett, and her 20-year-old son Tyler, who is a junior at the University of Tennessee, met with Chancellor Jimmy Cheek and Athletic Director Joan Cronan to inform them of her condition. Barnett warned Summitt that contractually school administrators had the right to remove her as head coach immediately. Instead, Cheek and Cronan listened to Summitts disclosure with tears streaming down their faces.
You are now and will always be our coach, Cheek told her. With the blessing of her university, she will continue to work for as long as she is able.
Life is an unknown and none of us has a crystal ball, Cronan says. But I do have a record to go on. I know what Pat stands for: excellence, strength, honesty, and courage.
To Barnett, Pats fight is characteristic; her determination to keep working, and also to act as a spokeswoman for Alzheimers, is not incompatible with the values she has always preached as a coach.
If you go back to her speeches, and her discussions with players through the years, you see several things, Barnett says. One is absolute dedication. Two is an unwillingness ever to give up. And three is an absolute commitment to honesty. And in this challenge that shes facing, she is displaying the exact traits that shes always taught. . . .Pat is going to run this race to the very end.
Tennessee will be in uncharted territory, as will Summitt herself: Alzheimers is an unpredictable and dignity-robbing disease, thus far without a cure. The schools concerns over leaving her in place range from potential embarrassment, to a decline in Summitts health, to the possibility that players could feel short-changed, or that the team is more about Pat than them.
Cronan, however, believes the exchange is worth it.
Think about the difference shes made, and the difference she can make going forward, Cronan says.
She points out that even as Summitt was struggling both mentally and physically with her undiagnosed condition last season, she led Tennessee to a 34-3 record, swept the Southeastern Conference regular season and tournament titles, and reached the NCAA tournament region finals.
Nevertheless, Summitt has agreed to a significant redistribution of her duties. In consultation with Cronan and her staff, her role will be redefined to give her colleagues more formal responsibility, such as calling plays during games. Summitt will continue to do what she has always done best: teach, and lead.
Tennessee is uniquely positioned to make the experiment work. Summitt has constructed a stable, deeply experienced staff: Assistants Holly Warlick and Mickie DeMoss have each been with her for at least 20 years, and Dean Lockwood has been around another seven. Together they have helped Summitt build Tennessees juggernaut: 1,037 career victories against 196 losses; 18 Final Fours; and eight national championships.
Ive got a great staff and great support system, and Im going to stick my neck out and do what I always do, Summitt says.
According to Tyler Summitt, there is no diagnosis that can accurately break his mothers fierce will, and famously incandescent energy. The reality of Summitt is that she is functioning and even cracking a few wry jokes. Ive forgotten I have it, she says, grinning.
In the past week she spoke at an orientation session for Tennessees athletes and sang the fight song Rocky Top to them, read the newspaper aloud over her morning coffee, appeared at a Hoops for Hope benefit for children with Downs Syndrome, worked on recruiting, and hosted a large dinner at her home to prepare her staff for her announcement.
Thus far, Summitt has exhibited only the limited outward signs of her condition. There is a faint sense of dimming, as if a jar has been placed over a candle.
On Tuesday afternoon, she walked into the Tennessee locker room to inform her current team of her condition. She was prevented from telling them earlier by the fact that two of her players had been in China in the World University Games and did not arrive home until late Monday.
I just want them to understand that this is what Im going through, but you dont quit living, she says. You keep going.
Didnt test for leadership
After several instances of forgetfulness last season, she says, I lost my confidence. She became increasingly hesitant, and withdrawn. She avoided meeting with players one on one, afraid she might say something wrong.
When the season ended, Summitt decided to visit the Mayo Clinic for a full examination. For three days she underwent a battery of tests, an MRI exam, a PET scan, a neuro-psychological evaluation, and a spinal tap. After the spinal tap, she was told to remain lying down for 20 minutes. Sitting still is not something that comes naturally to her. Five minutes later she announced, I feel fine, and jumped off the table. A nurse looked at Tyler, and lifted an eyebrow. Im not going to be the one to stop her, the nurse said.
She performed less strongly on the neuro-psych exam, which evaluated her mental status, and problem solving and spatial abilities. She was led into a small white room by a stranger who promptly began firing math questions at her and math has always been a sore subject with Summitt. Her college sorority sisters at the University of Tennessee-Martin had to do her homework for her.
Asked to count backward from 100 by 7s, she froze. Next, she was asked, Do you know todays date? She has never known the date. She deals with dates strictly on a need to know basis. Frequently, she doesnt even known the name of her hotel there have been so many of them, and they all look the same, and they are all called Radisson or Clarion or Hyatt or Hilton.
This has always been Summitt. She has always mislaid her car keys and forgotten where she put her cellphone. She has always juggled too many responsibilities, and obligations. For this reason, the numbers from her test results are somewhat misleading, according to her son.
They didnt test for leadership, Tyler says. They didnt test for relationships. They didnt test for basketball IQ. None of those things are on the test, it was just math problems. They asked questions she wouldnt know on a regular basis. So I dont think the test applies to what she does as a coach.
At the conclusion of the testing, Dr. Ronald C. Petersen, director of Mayos Alzheimers Disease Research Center, rendered his opinion: She appeared to have signs of the disease, though she would have to wait for the lab results to be sure. Summitt was so highly functioning that it actually delayed her acceptance of the diagnosis. Immediately after her stay at Mayo she rushed to the Southeast Conference annual meetings in Destin, Fla., then back to Knoxville to run a series of summer camps, and then hit the road again for a series of basketball tournaments to evaluate potential recruits.
Role reversal
It wasnt until August that the reality of her condition hit home. There was a pretty long denial period, Tyler says. At first she was like, Im fine.
When the blow finally fell, it was heavy. Summitt had always been the caregiver: Friends, family and former players struggling physically or emotionally have always come to her house for comfort, a hot meal and soothing advice in that honeyed southern voice. I want to go see Pat, is a common refrain. It wasnt easy to reverse the role, and to admit that she would need care.
In September 2006, not long after the death of her father, she separated from R.B. Summitt, her husband of 26 years. Some months later, she found herself immobilized by physical pain, and was diagnosed with rheumatoid arthritis. Summitt rarely betrayed in public the toll of that disease, but there were occasions, before it was successfully controlled by medication, when her son had to help her put her socks on.
In between those traumas she suffered a shoulder separation from fighting a raccoon and was hospitalized twice, once for cellulitis, and once for dehydration and exhaustion. Still, for all of that, she managed to lead the Lady Vols to consecutive national championships in 2007 and 2008.
Through it all, there has always been a sense of centeredness in Summitt. She is like a marble pillar, ramrod straight, that seems to have stood for a thousand years, while everything around it falls.
Everyone has always wanted to know what Pats really like, DeMoss said. The word Ive always used is resolve. Pat has more resolve than any one Ive ever known. She has a deep, deep inner strength.
But now she will need a different kind of counterintuitive strength. Surrender and acceptance have never come naturally to her, nor has admitting vulnerability. She has trouble even uttering the word Alzheimers. But shes learning.
We sat down and had a good talk, and realized that the only reason we even made it this far, was that we had each other, Tyler says. It started with her father passing away, and then the divorce, and the arthritis, and then the Alzheimers, and each of those things, I dont know how anyone could go through them alone. So we figured out that as much as we wanted to be Superman and Wonder Woman, and take care of things alone, we needed each other.
With acceptance has come relief and, thanks to treatment, apparent improvement.
Every morning she reads, or studies math problems on flash cards. Each night she spends hours working on her iPad, doing puzzles to improve her cognitive abilities.
Once she came out of her denial state, Tyler says, it was like a gun went off. She just bolted out of it.
Over the last few days, with the clarity of her diagnosis and decision to go public, Summitt has recovered her confidence. More often than not, it is she who comforts others, as usual. Her staff have grief-stretched looks around their eyes, and seem quietly destroyed under their skins. Every so often you find one of them has ducked into her laundry room to weep. Its Summitt who puts her arms around them and talks quietly into their ear. I dont want you worrying about me, she says. Strong has always been her natural, preferred state.
Tyler divides his time between his mothers sprawling house on the banks of the Tennessee River, and an apartment just off-campus he shares with two college friends, with her cheerful approval.
Most nights, however, he spends at home. When everyone departs the Summitt household there are two people left, gazing at each other with a deep, indestructible understanding. Suddenly, something becomes clear: Summitts qualities and legacy have been vastly underrated. All these years, while she was coaching basketball and teaching other peoples daughters, she very quietly and without any fanfare, did a stupendous job of mothering her son.
I followed her everywhere growing up, Tyler says. I followed her on bus rides, airplanes, in gyms and in locker rooms all over the country, and I thought she taught me everything she had. But she saved this lesson, to always come out and be open, to not be scared, to have the courage to face the truth like shes doing.
The boy, you realize with a start, is looking more like her all the time. He has the same scotch-red coloring, the same uplifted chin. The eyes are slightly different, a milder more limpid blue. But there is the same look in them, a quality. A candle.
(Washington Post)


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In response to "Politics stranger than Hollywood": Dick Cheney apologist B.K. Brooks (we know who was in charge of the White House during Dub's tenure) cites Leon Panetta for asserting waterboarding led to Osama bin Laden's fate. I pray to God that none of my grandchildren (or theirs') will ever be subjected to such a war crime. The U.S has a historical record of regarding same as a war crime. Spurred on by the Dick Morrises of the evidence-lacking hate-monger world, Brooks is mixing fact with fiction. "Zero Dark Thirty" does just that. It's borderline fascistic.
—Ray Estes, Chico

subset: commoncrawl


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Angels throttle A's to claim sixth straight win
Shoemaker cruises behind six-run second; Halos' lead at five games
ANAHEIM -- The Angels didn't get here -- in first place, and 30 games above .500 despite losing two starting pitchers in one month -- without some uncanny perspective. So the excitement in the home clubhouse at Angel Stadium was quite tempered, almost non-existent, late Sunday afternoon, even in the midst of so much to celebrate.
"We're having fun," Mike Trout said, "but it's still August."
Well, barely.
The 31st and final day of August brought the Angels an 8-1 victory that clinched a stirring, uplifting four-game sweep of the division-rival A's. It was the Angels' sixth win in a row and their 15th in the last 19 games. They now hold a 3 1/2-game lead on the Orioles for the best record in baseball and a five-game edge on Oakland in the American League West, with only one month remaining in the regular season.
That's a healthy lead, right?
"No," Angels catcher Chris Iannetta said, "because you know what? It can go the other way just as fast."
The A's can tell you all about that. Over the last 21 days, they've seen the Angels gain nine games on them, going from four back to five up since Aug. 10. In the finale, Matt Shoemaker pitched seven shutout innings, extending his own scoreless streak to 23 1/3 innings and extending the scoreless streak of Oakland's offense all the way to 29 innings, until the A's finally salvaged a meaningless run against Mike Morin in the eighth inning.
Before the weekend concluded, the A's -- swept by the Angels in a four-game series for the first time since 1997 -- held a closed-door meeting. "Embarrassing" and "pathetic" were the words A's manager Bob Melvin used to describe his team's performance in Orange County.
"Frustration, anger, disappointment, embarrassment, kind of all added up into how we don't do things as a ballclub," catcher Derek Norris said. "We need to figure it out, because if we don't figure it out, we're going to miss out on a lot of good opportunities that we've built up and that we've tried to do here. I feel like we put so much time and effort into the first X-amount of months into the season. To [throw] it away now would just be a ginormous waste of our time."
The Angels, meanwhile, haven't skipped a beat. They lost Tyler Skaggs to Tommy John surgery after the 23-year-old lefty suffered a partial tear of his ulnar collateral ligament on July 31, then lost frontline starter Garrett Richards to a torn patellar tendon on Aug. 20, injuries that left general manager Jerry Dipoto with no chance of finding a suitable rotation replacement.
On Thursday, they edged out a 4-3 victory on Howie Kendrick's 10th-inning, walk-off sac fly.
On Friday, they got seven shutout innings from their longtime ace, Jered Weaver.
On Saturday, eight relievers combined to throw a nine-inning shutout in what would have been Richards' turn.
On Sunday, they plated six runs in the second inning against Scott Kazmir, who has now given up 18 runs in 7 1/3 innings against his former team since the start of 2013, then watched Shoemaker take care of the rest.
Iannetta went 3-for-3 with a walk and an eighth-inning solo homer, Trout went 2-for-4 with a seventh-inning solo homer that gave him a career-best 31, and the Angels drew four walks in a second inning that provided all the runs they would need.
"We're having big innings, pitching well, playing defense -- all the things you need to do to win," Angels outfielder Josh Hamilton said. "It'd be cool if everybody could really hit their stride offensively towards the next couple of weeks. That would be pretty sweet. But as long as we're winning ballgames, we'll take it."
When September begins, Shoemaker will have 14 wins and a 3.14 ERA in 117 2/3 innings in the Major Leagues, numbers that even the most positive of thinkers never foresaw. His scoreless streak is the second longest for an Angels rookie, trailing only reliever Bob Lee's 27 innings in 1964. And he's the first Angels pitcher with three straight scoreless outings of seven or more frames since Nolan Ryan, who did it over a couple of seasons at the end of 1976 and the start of 1977.
Nolan Ryan and Matt Shoemaker -- imagine that.
"It's an honor to be mentioned by that name," said Shoemaker, the undrafted 27-year-old who completed an unfathomable march through the system.
"When he's on that mound, he thinks he's Nolan Ryan," Angels manager Mike Scioscia said. "He pitches with confidence."
The Angels carry that confidence collectively, but they also hide it well. Their bullpen has been one of the best in baseball for the last two months, their starting rotation -- shorthanded as it might be -- has found a way to consistently keep them in games, and their offense may still have another gear left in it.
But the schedule also has 26 games left, and the Angels refuse to get ahead of themselves.
"We just have to take care of the games ahead of us; take it one game at a time," Trout said. "Every series is going to be big. We can't scoreboard watch; we just have to keep playing our game."
Alden Gonzalez is a reporter for MLB.com. Read his blog, Gonzo and "The Show", and follow him on Twitter @Alden_Gonzalez. This story was not subject to the approval of Major League Baseball or its clubs.


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Been stumbling down the path for about 2 years now, piecing things together as I go along. Started off with an interest in Zen, delved into the golden age Chan and Sanlun of China, went on into Madhyamaka and have now settled into where I feel I should have began: a Thai Forest Theravada perspective based around the teachings of Thanissaro Bikkhu.
I requested books from Metta Forest Monastery and have been digging into Thanissaro Bikkhu's Dhamma talks for the last few months and am finally feeling like things are coming together. I'm here hoping to find true dhamma friends to discuss the path with and to learn what I can from those who have gone forth before me.


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The 180's Women's Winterlude Earwarmers provide the ultimate in warmth and comfort. Boasting a faux suede shell and faux fur lining, the behind-the-head design fits comfortably over your ears, whilst the adjustable frame will fit a variety of head sizes. The earwamers can be worn with other headwear, and collapse to easily fit into your bag. - L.M.
If ordered before 8pm, delivered by courier next working day. Available on orders placed before 8pm (2pm weekends and Bank Holidays) for delivery next business day. Applies to most delivery addresses within mainland UK.
Please remember to add postal time (2-3 working days) to obtain a complete estimate of delivery to your door.
You will receive an email to confirm when your item has been sent.
You can also check the status of your order and individual items by accessing My Account details and following the prompts.
Please allow 10 working days from dispatch of your order before notifying us of any late deliveries.
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Please see our returns policy.
There are currently no reviews.


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American Saddlebred Museum Presents Oak Hill Farm – A Jewel of the Bluegrass
Lovers of Kentucky's first native breed of horse, the beautiful American Saddlebred, will thoroughly enjoy the 2014 special exhibition entitled Oak Hill Farm – A Jewel of the Bluegrass, presented by the American Saddlebred Musem's Showplace for Saddlebreds on the grounds of the Kentucky Horse Park.
The exhibition explores the American Saddlebred showing and breeding empire of Harrodsburg's Oak Hill Farm. On display are hundreds of items, including photos, paintings, trophies and furnishings from the estate of the farm's owner Jean McLean Davis.


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You and Walker are going to have fun trying to stop Jermaine. Also, have fun with Artest or O'neal guarding you.
I hope Al gets a standing O from the crowd because he deserves it. We watched baby Al grow up for years and develop right before our eyes, now he is Big Al. Al was an important piece to our success last year, even when he was struggling in the Playoffs he still brought that energy off the bench.
I just can't help wonder what would have become of him if he didn't injure his knee.


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A LANDOWNER who left a sign warning residents to 'keep out' has been told to tidy the area up.
Residents near the patch of land between Hawley Street and Knotts Lane, Colne, were left confused last year when the owner erected a sign saying 'Private Farm. Danger. Deep Water. Keep Out'.
The same message was also sprayed on a wall as well as on a container left on the land.
After a year-long battle the council has now served a Section 215 notice on the landowner, which requires him to tidy the area.
Coun Tommy Cooney, who lives off Knotts Drive, said: "I see this eyesore every day.
"This man is just flying in the face of local residents, and has no concern for them whatsoever.
"It seems this is his way of getting his own back for not getting planning permission, which is not only childish but also shows the complete disregard he really has for the area.
"Now that this notice has been served, we can take firm action. He has to complete the work or we as a council can go in, tidy it up and bill him.
"Either way, it's time action was taken so that local residents don't have to live with this mess.
"From a community point of view, tidy gardens and land mean an area looks well cared for, making people feel safe in that neighbourhood."
Ward councillor and Colne Area Committee chairman Graham Waugh said: "We won't be pushed over. He'll either do the work, or pay for it being done. It's as simple as that."
In both planning applications for the erection of a house, the applicant was listed as a Padiham-based company called PLDS Company Ltd.


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CHILDREN at Wootton Bassett Infant School can make the most of their break time after a donation from Taylor Wimpey helped to fund new outdoor play equipment.
The pupils can now enjoy a look-out tower with ladders and a sandpit, a play store shed, a 'jungle' with tiered stages which will be used at playtime and for drama lessons, and water play equipment for the younger children.
The housebuilder, which is building new homes at its nearby Jubilee Park development in Wootton Bassett, donated £500 towards the cost of the play facilities.
Headteacher Mark Hazzard said: "We had limited play equipment before, but when you have 100 children running around the playground, they need things to do.
"We are grateful to Taylor Wimpey for their donation. The children are excited about their new playground and will much enjoy reaping the benefits."
Charlie Joseph, regional sales and marketing director for Taylor Wimpey, said: "We're delighted to be able to help the children at Wootton Bassett Infant School make the most of their playtime and hope they get many years of enjoyment from their new playground equipment."


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Account of attack that killed ambassador 'based on CIA information'
Washington: A UN ambassador's account of a deadly attack on the US consulate in Libya reflected the CIA's best information at the time, two Democrats on the House intelligence committee have said.
Republicans have said Susan Rice, the US ambassador to the United Nations, misled the public in September when she went on television five days after the attack and said it was the result of militants hijacking a protest against an anti-Islamic video.
Ms Rice has been touted as a potential replacement for Hillary Clinton as secretary of state. The President, Barack Obama, leapt to her defence on Wednesday when two Republican senators, John McCain and Lindsey Graham, said they would oppose Ms Rice's nomination should Mr Obama choose her as secretary.
Mr Obama said Ms Rice had done "exemplary work" and "to besmirch her reputation is outrageous".
The US ambassador to Libya, Chris Stevens, and three other Americans died in the September 11 attack. The acting CIA Director, Michael Morell, told lawmakers in a closed-door briefing this week that Ms Rice's account was based on an early agency assessment that the attack stemmed from a spontaneous demonstration, congressmen Adam Schiff and Charles Ruppersberger said.
"For those who are claiming the UN ambassador had some different information, they're either unfamiliar with the facts or willfully ignoring them," Mr Schiff said.
Jeff Duncan, a Republican, said at a hearing of the House Foreign Affairs Committee: "If Ambassador Rice had nothing to do with the Benghazi cover-up, then why did the administration use her as a mouthpiece?"
He has circulated a letter urging Mr Obama not to nominate Ms Rice as secretary of state.
The retired General David Petraeus, who resigned last week as Central Intelligence Agency director after acknowledging an extramarital affair, will brief the House and Senate intelligence panels today in separate closed-door sessions.
General Petraeus told Congress in a briefing soon after the attack that it was spontaneous, but that assessment was preliminary, Congressman Ruppersberger said.
Two weeks later, a spokesman for the Director of National Intelligence, James Clapper, said the intelligence community had revised its assessment "to reflect new information indicating that it was a deliberate and organised terrorist attack carried out by extremists".
Two department officials have said there were no protests at or near the Benghazi compound the day of the attack.
The Senate committee watched a film that showed the attack taking place. Senator Roy Blunt, a Republican member of the Senate intelligence panel, told CNN the video substantiated revised assessments that there was no protest outside the consulate.
"It's not hard to establish there was no demonstration, there was no crowd," Senator Blunt said. "When this started, it was an act of violence."
Congressman Ruppersberger, the top Democrat on the House intelligence panel, said Ms Rice "was given the same information we received from the administration through the intelligence community".
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Just saw this on Fox News...details coming in
They are saying it is either a murder-suicide or double homicide...tragic.
I know this should be moved eventually to the Colts board or Club Rio but I thought it would get the most traffic here initially.
Link: http://www.newschannel5.com/global/story.asp?s=10643962
Police just confirmed (4:38), they are now calling it a double homicide.


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Bob's Red Mill is excited to bring you NEW Gluten Free Granolas! We took our two most popular granola flavors—Apple Blueberry and Honey Oat—and switched out a few ingredients to create the tastiest gluten free granola you've ever had. We carefully monitor each ingredient throughout the entire process, from farm to packaging, to be sure you are getting the highest quality gluten free product.
We use only pure, high-grade gluten free oats. Each farm delivery is tested with an R5 ELISA gluten test to ensure the absence of gluten. Advanced color-sorting removes undetected impurities. Roasting enhances that wholesome robust flavor you expect. Finally, the oats are moved to our 100% gluten free facility and tested for gluten again to ensure their purity.
To these pure oats, we add a little bit of sugar and flavorings for a lightly sweet, crunchy granola you'll want to eat right out of the bag. Made using the same process (but not the same lines) as our regular granolas, these new Gluten Free Granolas are sure to become favorites in your house.
To celebrate our new additions, we're giving away a package of each new Gluten Free Granola, Apple Blueberry and Honey Oat, to five lucky winners. To enter, follow the prompts below. We'll select five winners at random from all who enter by 11:59 pm on 05/22/14.


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Infante scratched; Colon starts at second
Second baseman Omar Infante was scratched from the Royals' starting lineup on Friday night because of tightness in his lower back. Infante was on the disabled list from May 7-26 with an inflamed lower back, but he had played all but one game since then.
Christian Colon, called up from Triple-A Omaha, got his first Major League starting assignment as Infante's replacement against the Indians.
Colon got his first big league hit, a triple to center field, in the third inning off Josh Tomlin and scored his first run on Cain's single. Colon was 0-for-2 in his only other game.
Dick Kaegel is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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The Centre for Particle Physics Phenomenology, dedicated to the understanding of the origins of bright and dark matter in the universe (CP3-Origins), is one of the new generation of centres of excellence chosen by the Danish National Research Foundation (DNRF) to receive significant funding for the next 5 + 5 years.
(1 position listed)The application must include the following: * A curriculum vitae. * A full list of publications. * A brief survey of the applicant's most important research results and research plans. * At least three letters of recommendation. CP3-Origins encourages all interested persons to apply, regardless of age, gender, religious affiliation, or ethnic background.


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Mark Ellis wrote:Blake, You write as a scientist or engineer. But many of your readers don't have that background and probably miss much of what you are explaining. I know I do.
I know I'm guilty of this as well. I try to tone down my technical language as much as possible and shoot for intuition, but its still hard. I was a student in physics, math, and natural sciences for over a decade, and after that I crossed a sort of threshold in my thinking (well, that was the purpose of it all, I suppose). But still it is very important to try and make things easier to understand for others.
Mark Ellis wrote:So for writing purposes your ghost writer/collaborator should be someone who has a background in science and the ability to break down and explain the technical terms used. And the patience to do this. In addition, drafts should be tested on different players to see how much they are actually absorbing.
Boy would I love to have the time to do this! I just have to figure out a way to earn a salary or living to support my family (especially since I'm not a good enough player to make any cash at all in tournaments ).
Mark Ellis wrote:The greater need is for you to do videos. The easiest way to understand motion is to watch it...Imagine if I wanted to explain to someone how to tie a necktie. A hundred thousand words, carefully and skillfully chosen would be inferior to a simple video showing how to do it for most interested learners.
Mark, you must have worked on the videos you have done, with some basic scripts, a plot, etc.. Could you tell us more about the process? Putting together the script/plan, deciding how to film it, doing it, and then of course editing...this is not straightforward, and requires even more work, perhaps, than just the distillation into coherence as an article that Blake is proposing above. But I agree it is definitely worthwhile!


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Above: Adon from Turok 2 isn't quite as nice to look at as you remember, is she? She has it better than most
Now, though… it's not so much that we no longer want to see these characters naked as that we wouldn't want to be in the same city where they were naked. As badly as their games have aged, these former sex symbols have it worse, going from objects of desire to terrifying box-monsters with creepy heads and pyramid breasts. In the name of embarrassing everyone who lusted after them and mortifying everyone who didn't, we've rounded up a selection of these sad creatures and put them on display.


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How to update a translation of Visitor Maps for WordPress:
This article explains how to take an existing language file and update it. Sometimes a language file will be older than the current version of Visitor Maps for WordPress. In that case there may be some text that appears in English instead of the set language. See also: How to translate Visitor Maps for WordPress
How to switch the language for Visitor Maps in WordPress:
Set WPLANG inside of wp-config.php to your chosen language. For example, if you wanted to use Italian:
define ('WPLANG', 'it_IT');
Note: there must be a corresponding language files in the plugin folder: /wp-content/plugins/visitor-maps/languages/
For example, if you wanted to use Italian:
Updating a Translation With Poedit:
You should download the free Poedit to translate, because it makes it easier to translate.
Before you start: Download the plugin POT file, look for the link below or find it in the plugin languages folder. Getting the latest one online is recommended. Download the language .pot file for Visitor Maps
Open Poedit and click "File – Open", select the .po file in your language. To find the .po file for the translation in your language. Look in the plugin languages folder.
The country code is part of the file name. Example for Italian: it_IT. The Italian file of this WordPress plugin is named like this: visitor-maps-it_IT.po
Make sure you first have the current .po file open in Poedit, then Click "Catalog – Update from POT file". Now all you have to translate are the new language strings that have been added to the plugin since the language file was last translated.
Entries are arranged in a list, so that you can easily navigate large catalogs and immediately get an idea about how big part of the catalog is already translated, what needs translating and which parts are only translated in a "fuzzy" way. Fuzzy and untranslated records are highlighted and displayed at the top of the list. Start at the top of the list and translate each line.
When done translating click Save.
Poedit will automatically save the .mo and .po files needed by this plugin. Be sure to name them like this:
Example for Italian: it_IT.
Copy the language files into the plugin folder:
When you have updated a translation, please make a support ticket and request to submit your language files to be included in the plugin download. Be sure to include your name and your web site URL for the credits.
More info:
See also: How to translate Visitor Maps for WordPress
Send us a Donation:


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Outbound Shipping Coordinator - Tilburg
About Tesla
Palo Alto, California-based Tesla Motors designs and manufactures Electrical Vehicles and EV powertrain components. Tesla's goal is to produce a full range of electric cars from sports cars to mass-market vehicles and we are determined to decrease the cost of electric vehicles. We have designed, produced and delivered Tesla Roadsters to customers in North America, Europe and Asia Pacific. Model S, the world's first premium electric sedan is now being rolled out world-wide.
The Role
In this position you will ensure Compliance on logistic moves and liaison with compliance on joint projects. The successful candidate will oversee and execute preparation of all required documentation (CMR and ADR notes, Commercial invoices, packing slips, Delivery Notes) for import/export &domestics shipping functions Introduction of the role and business unit.
Tesla Motors is committed to a policy of equal employment opportunity. We recruit, employ, train, compensate, and promote without regard to race, colour, age, sex, ancestry, marital status, religion, national origin, disability, sexual orientation, veteran status, present or past history of mental disability, genetic information or any other classification protected by state or federal law. A EU passport or work permit is required for this position.
United States
|Web Site:
|1050 Bing Street
San Carlos, CA 94070
United States
|Cleantech / Energy
Support Tesla Motors with Social Media services
Find more Outbound Shipping Coordinator jobs


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On March 6, 2017, Gurcharan Bawa was officially announced as the General Manager of Pasadena Water and Power. He previously held the Interim General Manager title for seven months as the City of Pasadena conducted a nation-wide recruitment. Mr. Bawa joined PWP in 1992 as an Associate Environmental Engineer. Prior to his appointment as General Manager, he was the Assistant General Manager of Power Supply, ensuring a reliable and cost-effective supply of power for Pasadena. He oversaw the City's local power plant and the Glenarm Power Plant Repowering Project, which will allow PWP to reduce fuel consumption and emissions while increasing reliability. Mr. Bawa was also responsible for incorporating renewable energy resources into Pasadena's overall energy portfolio. In addition, he managed legislative and regulatory affairs related to power generation and transmission.
Mr. Bawa is a licensed professional engineer in mechanical and civil engineering. In 2014, he was selected to participate in the Senior Executives in State and Local Government program at the Harvard Kennedy School of Government.
For more on Gurcharan Bawa and the other executives of Pasadena Water and Power, click here.
Pasadena Water and Power is committed to providing safe and reliable water and power with superior customer service at reasonable rates.
PWP has provided customers with reliable electric service for over a century. As a community-owned utility, PWP's first priority is to serve our customers.
As the City of Pasadena has grown and prospered through the years, so has PWP. During the Great Depression we provided much-needed jobs, and in World War II we pitched in with the war effort. In recent years, PWP has contributed to city services that improve the quality of life for everyone who lives and works in Pasadena - services like fire and police protection, street lights and maintenance, community centers and assistance to low-income residents.
PWP customers have made an "investment" that continues to work for the mutual benefit of the community and the City of Pasadena.
Electricity is not a faceless commodity in Pasadena. Indeed, PWP could not have survived for nearly a century in one location without being personally dedicated to serving our customers' energy needs. Now, as PWP continues to meet the changing needs of a vibrant, growing community, our response to emergencies remains unequaled. Our preventive maintenance continues to keep our infrastructure reliable. We are committed to service our customers in a friendly, professional, and effective manner.
PWP offers the highest standard of commitment to commercial and mass market customers through personal account manager services. Through analyzing energy and water needs and implementing low-cost solutions, our PWP account managers are working with our customers' bottom-line in mind.
PWP continually develops and offers a wide range of customer service programs to fit the needs of Pasadena business and industry. From conducting energy and water use evaluations for commercial facilities, to creating innovative solutions that help customers manage their energy and water requirements, PWP works in partnership with each customer. PWP considers technology and regulatory requirements when evaluating and projecting customer needs by offering a list of options and opportunities for saving money on energy and water use.
These partnerships are working. Many outdated, inefficient energy systems in commercial sites throughout Pasadena are being upgraded or replaced with the help of Pasadena Water & Power's creative incentive programs.
Pasadena Water & Power also partners with local retailers and distributors to deliver PWP products and services to commercial customers.
PWP has an enviable history of reliability which is reflected in the services PWP provides to its customers.
PWP continues to receive high ratings from the financial community. Throughout the years, PWP has operated under strictly conservative principles that put the needs of our customers first. Those principles have paid off with high financial ratings.
PWP's Strategic Plan outlines the initiatives we are pursuing to accomplish our mission. It aligns with the City Council's Strategic Plan, incorporates approved resource and infrastructure policies, and highlights the key areas which will be our focus over the next three years.
Built upon PWP's core values, which have endured for more than a century – Community and Customer Focus, Safety, Sustainability, Accountability, Dedication, Honesty and Integrity, and Innovation the plan is focused on six areas key to PWP's success:
PWP's most ambitious undertaking has been its successful transformation from a protected monopoly to a strong, competitive and service-oriented business. Every transaction, every recommendation, and every decision is made with our customers and community in mind along with a watchful eye on the bottom-line.
PWP is committed to to being the community's "provider of choice" for water and power related services. We're not newcomers - we've been established in Pasadena since 1906, that's over 100 years!
With PWP's local presence, updated facilities, and innovative programs, PWP can offer total energy services more efficiently and reliably than any other provider. PWP is planning to provide even more efficient and lower-cost energy while maintaining our high standards of reliability and service.


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LAKEPORT -- Clear Lake lakeside residents could see some major regulations on their domestic use of the water from the lake to protect the Clear Lake hitch.
At a Chi Council meeting on Wednesday, Kevin Thomas of the Department of Fish and Wildlife (DWF) outlined to the council the effect of the petition by the Center for Biological Diversity to place the Clear Lake hitch on the endangered list. The group petitioned U.S. Fish and Wildlife Service (FWS) as well as the California Fish and Game Commission to list the hitch as endangered. The FWS hasn't yet acted on the petition but the Fish and Game Commission initiated a year-long study on the hitch and ordered the DFW to supply scientific data on the fish. According to Thomas, by the commission accepting the petition new laws will automatically apply to the hitch and they include that no take of hitch is allowed. Thomas said the definition of "take" means a hitch cannot be killed, harassed or its habitat changed in any manner. For example hitch can't be disturbed in any way which includes harming them in the spawning streams or in the lake. In the past many people would kill hitch by clubbing or stoning them as they migrated up the streams. That is now illegal and citations can be issued. Even wading in a stream past migrating hitch is illegal. Assisting a hitch in migrating a stream is also illegal.
The surprise for many at the Chi Council was when Thomas said that all lakeside residents who draw water from the lake using a pump will be required to first have a permit and small mesh screens must be installed to prevent young hitch fry from being sucked up into the pumps.
There are literally hundreds of pumps installed at the docks on Clear Lake for watering lawns and gardens. Thomas said these water users must now apply and receive a permit before they will be allowed to pump any water from the lake. He also said that if the pump or intake pipe is anchored to the bottom of the lake they must also apply for a permit under the Fish and Game code 1601, which applies to any alteration of a lake or streambed. The cost and instructions on how to apply for permit aren't yet available.


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Note: This item is more than nine years old. Please take the publication date into consideration for any date references.
Print – Plain Text – Permalink
News Release
Media Contact: TPWD News, email@example.com, 512-389-8030
Sept. 14, 2008
Ike Update From TPWD: Game Wardens Search and Rescue, State Parks/Wildlife Staff Assess Damage
Noon CDT — Update 6
Below is information sent by Texas Parks and Wildlife Department to the Governor's Press Office today. The governor's office is coordinating official communication about Ike for the State of Texas, including TPWD activities. The following information is provided as a service and convenience for TPWD's audience. For complete information, see the Texas governor's web site at http://governor.state.tx.us/, or news media may phone the press office at (512) 463-1826.
Texas Game Wardens/TPWD Law Enforcement Division
- TPWD has more than 180 game wardens and associated boats and equipment deployed in Southeast Texas.
- This morning, five game warden strike teams with airboats and riverboats fanned out across Southeast Texas for search and rescue and damage assessment. Teams are working today in Beaumont, Orange, Port Arthur, Bridge City, and Chambers County. It's anticipated that search and rescue duties will continue in Orange County for three-to-six days.
- Yesterday, Capt. Rod Ousley of the Beaumont office and eight game wardens worked in Bridge City and Orange with airboats. By 4 p.m. they had completed more than 50 rescues, plucking people from rooftops and second story windows, bringing them back to National Guard trucks.
- Six other strike teams of 10 game wardens each are on standby today, three at Lake Bob Sandlin in Northeast Texas, and three more teams at Camp Allen near Navasota, awaiting deployment instructions from the State Operations Center.
- In Galveston, about eight game wardens normally based in that area continue to help patrol and search residential areas, using boats to navigate flooded streets in some cases.
- Dozens of other wardens based out of Region 4 in Houston are likewise continuing to search, rescue and assess damage in the counties and city areas they normally patrol.
Texas State Parks
- More than 30 Texas State Parks remained closed due to Ike in Southeast and East Texas. For the current list of park closures, see the TPWD Web site (tpwd.texas.gov/spdest/parkinfo/hurricane).
- As of 5 p.m. yesterday, a total of 4,673 evacuees have been given shelter free of charge at 45 state parks outside the hurricane's path.Evacuees from storm-damaged areas are allowed to tent campor stay in RVs or campersat no cost in Texas State Parks, and they may stay in cabins or screen shelters at discounted rates. The latest information on parks closed or accepting evacuees is available through the TPWD Web site (tpwd.texas.gov/site/emergency). The public can also phone individual state parks to see whether a park is closed or accepting evacuees.
- More damage assessments for the State Park Division came in this morning, though the full picture is still incomplete. Southeast Texas state parks sustained the most damage, where seven parks have reported significant impacts.Stephen F. Austin, Brazos Bend, San Jacinto Battleground, Village Creek and Huntsville sustained wind damage to treesand structural/infrastructure damage. No loss of life or injuries have been reported for the State Parks Division.
- In Northeast Texas, parks west of Tyler fared fairly well, although many reported trees down. Eastern parks like Martin Creek Lake, Caddo Lake, Daingerfield, and Atlanta sustained more damage. All of these are without electricity, with power lines down and poles broken, likely to remain closed for some time. Trees fell on some cabins and buildings at Martin Creek, though details are not known.
- The headquarters building at Mission Tejas burned to the ground around 10 a.m. this morning. No one was hurt. It is possible that an emergency generator being used to power the building caught on fire.
- Wildlife Division staff assisted with search and rescue in Jefferson County at the request of local officials, and other staff are assessing damage to facilities and habitats in affected areas.
- Several Southeast Texas wildlife management areas near the coast where the landscape normally consists of wetlands, marshes and coastal prairies are all or partly underwater today, including the Murphree, Candy Abshier, Lower Neches and Hursts WMAs. Various WMA buildings and facilities sustained mostlyminor damage. A shop building at Murphree WMA was destroyed.
- Regarding ecological impacts, aerial overflights of the upper coast region are planned for Monday to assess damage to various TPWD division facilities and to natural resources. But longtime division staff member and Murphree WMA Superintendent Jim Sutherlin had this to say: "The Murphree area looks like the Gulf of Mexico. Wildlife impacts to every thing that doesn't fly will be significant like it was back in the early 1960s with Hurricane Carla. I expect a great reduction in reptiles and amphibians, particularly alligators, but also snakes, frogs, all the things that move on the ground in the coastal plains. We need to assess the full impacts, and that will take some time. It will set plant communities back to very early successional stages, and we'll see big changes in the landscape when this water comes off, for a couple of decades. That's something we'll see as our careers mature, and the young people starting careers in wildlife ecology now will follow it as we followed Carla."
On the Net:
- TPWD Emergency Information: http://tpwd.texas.gov/site/emergency/
Publication — Permission is granted to publish, in whole or in part, any news releases on this page.
Print — A print-friendly version of the news release shows only the release with font sizes set to the browser default.
Plain Text — Plain text versions of TPWD news releases are provided for copying and pasting into editing software.
To copy text into an editing software:
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English/Spanish — News releases posted in both English and Spanish have one of these links.
If you have any suggestions for improving these pages, send an e-mail to email@example.com and mention Plain Text Pages.
(5.4.16 i)


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GSA Ranked as One of the Best Places to Work in Federal Government
Effective leadership key to increased employees satisfaction
September 1, 2010
Contact: Sahar Wali, 202-208-0438
WASHINGTON – GSA, stewards of the federal workplace and the government's premier provider of goods and services, is also one of the government's top employers. Today, the agency was recognized by the Partnership for Public Service as one of the Top 10 Best Places to Work in the Federal Government for the fifth straight time.
"This is a true testament to the work that GSA employees do day in, day out to help make government work better for the American people," said GSA Administrator Martha Johnson. "It also shines a light on GSA's leadership team, which has been instrumental in creating an employee-friendly culture that rewards innovation, values customer relationships, and is committed to operational excellence."
The agency ranked eighth overall and received high marks in the areas of strategic management and performance-based awards where it ranked third among large agencies, and second in work/life balance and compensation. The agency also received top-10 rankings in each of the following leadership categories: Management Fairness; Employee Empowerment, Supervisory Leadership, and Senior Leadership. In 12 of the 15 "Best in Class" scores, the agency scores increased over the previous survey, with an average score increase of 3.5.
"I am particularly pleased to see GSA's ranking in strategic management, as we continue to leverage our position as the federal government's procurement and real estate to assist other agencies in fulfilling their missions," Johnson said.
The ranking, which is produced by the Partnership for Public Service and the American University's Institute for the Study of Public Policy Implementation, is compiled from overall employee satisfaction data.
The 2010 Best Places to Work rankings include 290 federal organizations and are based on response from more than 263,000 federal employees.
GSA employees support construction, acquisition services, and policies that together influence more than $500 billion a year in federal spending. From the preservation of buildings that are part of our nation's legacy, to projects on the forefront of green building to procuring an annual $60 billion in annual business volume of cost-efficient products and services in office supplies to IT and telecommunications solutions.
GSA provides a centralized delivery system of products and services to the federal government, leveraging its enormous buying power to get the best value for taxpayers.
• Founded in 1949, GSA manages more than 11 percent of the government's total procurement dollars and $24 billion in federal assets, including 8,600 government-owned or leased buildings and 213,000 vehicles.
• GSA helps preserve our past and define our future, as a steward of more than 480 historic properties, and as manager of USA.gov, the official portal to federal government information and services.
• GSA's mission to provide superior workplaces, expert technology solutions, acquisition services, purchasing and E-Gov travel solutions and management policies, at best value, allows federal agencies to focus on their core missions.


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Pigeon Point Lighthouse Hostel
Location: 210 Pigeon Point Road, Pescadero (50 miles south of San Francisco on Highway 1).
Information: 650-879-0633, www.norcalhostels.org/pigeon.
Rooms: Dorm beds in rooms that sleep up to six people for $25.50-$28 a night; Private rooms are $76-$168, depending on number of beds.
Hot tub: The cost is $8 per person for a half hour, with a two-person minimum and four-person maximum.
• Pigeon Point Lighthouse, which has been in operation since 1872. The lighthouse is currently being readied for renovation, so tours of the structure are not currently available.
• A hiking path with beautiful views of the coast.
• Half-hour guided history walks around the grounds are available from state park docents on Fridays, Saturdays, Sundays and Mondays, 10 a.m.-4 p.m.
• A wooden boardwalk leads visitors out to the rocky point.
• Tide pools can be seen a mere 100 yards north of the hostel during low tide, teeming with starfish, crabs, mussels, abalone, sea anemones and other marine creatures.
— Kevin Smith
There's something mystical about lighthouses — something otherworldly in the way they rise up from the ground and cast off their surroundings.
That's the feeling I got when I stayed at Pigeon Point Lighthouse, the tallest lighthouse on the West Coast. Perched on a cliff 50 miles south of San Francisco, the 115-foot-tall structure has been guiding mariners since 1872.
Now I need to clarify something up front. I didn't actually stay in the lighthouse. But my wife and daughter and I did stay in the hostel that's part of Pigeon Point. And before you run screaming from the room, I want to add yet another clarification: Pigeon Point Lighthouse Hostel bears no resemblance whatsoever to the bleak and blood-soaked torture chamber depicted in the horror movie "Hostel."
I saw nary a torture session during our stay at Pigeon Point. But abuse of a different kind was underway a little farther south where travelers were forking over nearly $6 a gallon for gas in Big Sur. Ouch!
Pigeon Point has four cheery dorm rooms, four family rooms and four private rooms, with a total of 60 beds.
We had stayed at a couple of other hostels before and we'll only do it if we can get a private room. I mean, who wants to bunk with Walt, the chatty used car salesman from Cleveland, or Felicia, the overzealous life coach who wants to sell you healing vitamin waters?
Not me, and probably not you, either.
The rooms are simply furnished but clean and affordable starting at around $76 a night for a private room with a double bed and single bunk above.
That was perfect for the three of us. Each of the four buildings also has a full kitchen and a common room stocked with an assortment of books, games and sometimes even a piano. Ours had an aquarium and a miniature pool table.
But you wouldn't want to hang out there too long because there's plenty of other stuff to do outside, like that great hiking path that circles the grounds and eventually drops you down on the beach.
They also have an oceanfront boardwalk and a private Jacuzzi. Their website says you can rent the Jacuzzi for $8 a half hour, but our host let us use it for free. Perched on the coast above soaring brown pelicans, Pacific harbor seals and migrating gray whales, it offers a soothing escape from your troubles. And if you're heading south toward those gas prices, you'll meet trouble soon enough.
The lighthouse still dominates the landscape at Pigeon Point, but it's in need of repair.
A worker at the hostel said the upper brickwork eventually began bulging under the weight of the heavy Fresnel lens that had long served as its beacon.
So the one-ton lens — standing 16 feet tall and 6 feet in diameter — was carefully disassembled and brought down via a zip line. It's currently on display in the Fog Signal Building, where it's been housed since 2011. Pigeon Point is still an active U.S. Coast Guard aid to navigation, but it now operates with a 24-inch aero beacon.
The restoration project will cost an estimated $10 million, and I'm told they've already raised about half of that. So hopefully the lighthouse will be fully operational and open for tours in the not-so-distant future.
So I've told you about the accommodations, the grounds and the restoration project.
But I didn't talk about the intangibles — the feeling you get when you're out on the point with the waves crashing against the rocks. Or the night stars that are so clear and bright it feels like you could pull them right out of the sky. Or the way all of this makes you feel so small ... and yet so connected to everything.
No, I'll leave that part up to you.
And yes, there is something mystical about lighthouses.


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United States Department of Agriculture
Agricultural Research Service
Aerial view of the U.S. Meat Animal Research Center Swine Farm
U.S. Meat Animal Research Center New Gilt Barn built in 2016
U.S. Meat Animal Research Center New Sow Barn built in 2016
Nursing Piglets at U.S. Meat Research Center
The primary efforts of the Reproduction Research Unit are directed toward improving the reproductive and production efficiency of swine. Major inefficiencies in swine reproduction include poor entrance and retention of females in the breeding herd and high perinatal and neonatal losses of piglets. Research of the unit involves physiology, endocrinology, behavior, molecular biology, neuroendocrinology, biochemistry, nutrition, and genomic analysis. Increased understanding of factors that influence puberty, estrus, sexual behavior, ovulation, implantation, embryonic and fetal mortality, parturition, lactation, early postnatal mortality, and return to cyclicity after weaning is required for improving reproductive efficiency. Specific research efforts investigate factors affecting gilt development, retention of sows in the breeding herd, increasing the number of quality pigs weaned per litter, and development of genomic markers for these and other production traits.


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Willingham honored following big '12 season
MINNEAPOLIS -- Twins left fielder Josh Willingham was honored before Sunday's game against the Rangers for winning the Silver Slugger Award last season.
Willingham hit .260 with a career-high 35 homers and 110 RBIs that year, his first with the Twins, en route to winning his first career Silver Slugger Award.
"It's deservedly so," Twins manager Ron Gardenhire said. "We thought he should've been an All-Star last year. But he didn't get picked, which was a big disappointment for our organization and him I'm sure. But he had a great year and did everything he was supposed to do when we brought him over here. So it's well-deserved."
Willingham also leads the Twins with four homers this season, including two against the Rangers this series. With his two-run shot Saturday, he passed Jim Thome for the most homers in Target Field history with 25. "I think it's pretty neat," Willingham said.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.


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5th Annual Don Meyer Evening of Excellence
Saturday, April 27
Allen Arena
2 p.m. and 7:30 p.m.
Both shows currently sold out.
Phil, Miss Kay & Si Robertson, the stars of A&E's "Duck Dynasty," are the featured speakers for the 5th Annual Don Meyer Evening of Excellence. "Duck Dynasty" is a reality television series depicting the lives of the Robertson family, which went from poverty to wealth due to the sales of their duck calls, primarily the "Duck Commander". The family business began in a dilapidated shed, where Phil Robertson spent 25 years making duck calls from Louisiana cedar trees. His son Willie is now the CEO of the company."
Duck Dynasty" drew more than 4.9 million viewers for at least one November episode, making it the #1 show on cable.
The Don Meyer Evening of Excellence is an annual athletic fundraising event named after long-time Lipscomb University men's basketball coach Don Meyer, who impacted the lives of countless thousands while at the helm of the Bisons. Meyer, the winningest men's collegiate basketball coach of all-time, was involved in a life-changing car accident on Sept. 5, 2008 that led to eight surgeries and the amputation of his left leg below the knee. He was subsequently diagnosed with cancer in his liver and small intestine. Meyer was awarded the "Jimmy V Award for Perseverance" from ESPN at the ESPY Awards in July 2009.


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Match Day is
March 16, 2018
General Information
Board Exams
Residency Planning
Away Electives
Career Resources: College of Medicine
Career Development for students in the College of Medicine is offered on an individual basis through assigned faculty advisors and through advisory Deans in the division of Student Affairs.
Student Affairs Deans and members of the clinical faculty make formal presentations to MS III students concerning the process and procedures involved in obtaining a Residency.
Specific requirement factors that might enhance a student's chance of being accepted into a given Residency Program are discussed. Thus, students have a solid understanding of how the Residency selection process operates and which variables may be of importance in their particular area of interest.


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Many Things to Many PeopleRiddles are little poems or phrases that pose a question that needs answering. Riddles frequently rhyme, but this is not a requirement.
To the bold, I am a weapon;
To the gallant, I am a pin;
To the gracious, I am a service;
To the bridesmaid, I am a win.
To the traitor, I am a bribe;
To the star, I am a screen;
To the swift, I am an arrow;
To the bride, I am a dream.
What am I?
AnswerSilver. Silver Bullet is a magical weapon. Silver Star is a decoration for gallantry in action. Silver Service is an A-1 type of service for hosts. Silver Medal is awarded to runner-ups or bridesmaids. Judas got pieces of silver for betraying Christ. Silver Screen is film industry for movie stars. Silver Arrows is name for Maclaren-Mercedes cars in F-1. Silver Wedding is a dream for all brides.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this riddle, keep track of
which ones you have seen, and even make your own.
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After obtaining the approval of the Food and Drug Administration (FDA), of national health authorities in Europe, and of local ethical committees, GENFIT has entered the operational phase of the international study GFT505-212-7. The first clinical investigation centers have been opened in the United States and in Europe, and the first patients are already under treatment. This study will involve a total of more than 75 centers of clinical excellence and will include 270 patients with a histological diagnosis of NASH at recruitment. All the clinical centers will be opened by the end of January 2013, and the last patient should be recruited by October 2013 at the latest. The final results are expected in December 2014, when GFT505 should become the first dedicated drug candidate with proven therapeutic efficacy in NASH.
Based on the prior recommendations of the FDA and the European Medicines Agency (EMA) concerning the global development plan for GFT505 in NASH, the primary aim of this pivotal double-blind study is to demonstrate the efficacy of one year of treatment with GFT505 at two doses (80 mg and 120 mg) versus placebo (90 patients/group) on the reversion of NASH in diabetic and non-diabetic patients. Multiple secondary objectives, in particular the demonstration of the effects of GFT505 on steatosis, inflammation, liver cell damage, and histological fibrosis, will also be pursued. Moreover, a large panel of plasmatic efficacy markers will be measured, including lipid profile, glycemia, and markers of inflammation and liver function. Patient safety will be assured throughout the study by an independent committee (Data Safety Monitoring Board). Finally, a particular focus will be made on the validation of diagnostic markers that could be developed as companion tests.
Prof. Vlad Ratziu, Principal Investigator and International Coordinator of the GFT505-212-7 study, declared:
« The large number of US and European clinical centers and internationally-recognized NASH experts involved in the GFT505-212-7 study illustrates the significant unmet medical needs in NASH and the hopes raised by GFT505 for this therapeutic indication. This is without a doubt one of the most complete NASH studies initiated in terms of patient number, length of treatment, and the number of associated clinical and biological analyses. As the principal investigator and international coordinator of the study, I am very pleased that the first patients have been recruited, and am confident as to the organization set up by GENFIT to successfully accomplish this study ».
Dr. Rémy Hanf, EVP, Product Development and Translational Medicine at GENFIT, declared: «The initiation of this pivotal study is a key step in the vast development program that we have discussed with the health agencies. For example, during 2013, GENFIT will set up complementary clinical trials and will initiate the development of new formulations of GFT505 for Phase III studies. Moreover, studies to determine the mechanism of action of GFT505 on fibrosis have been launched, and the first results show a direct effect of the molecule on the cells that are responsible for fibrosis development. Overall, the investments made are in keeping with the potential of GFT505 in this new indication».
*About NAFLD/NASH:
NAFLD (non-alcoholic fatty liver disease) and in particular NASH (non-alcoholic steatohepatitis) are serious liver diseases that can lead to cirrhosis and liver cancer. The development of NAFLD/NASH is associated with the pathophysiological process of insulin resistance in patients that are overweight and/or diabetic. NAFLD is believed to affect 70-80% of diabetic patients, and progresses to chronic liver disease (NASH) in 20-50% of cases. Mortality due to liver disease is thus 2-3-fold higher in the diabetic population than in the overall population. The NASH market was estimated at 615 $M in 2010 and should reach 2,008 $M in 2018.
About GENFIT:
GENFIT is a biopharmaceutical company focused on the Discovery and Development of drug candidates in therapeutic fields linked to cardiometabolic disorders (prediabetes/diabetes, atherosclerosis, dyslipidemia, inflammatory diseases…). GENFIT uses a multi-pronged approach based on early diagnosis, preventive solutions, and therapeutic treatments and advances therapeutic research programs, either independently or in partnership with leading pharmaceutical companies, including Sanofi, to address these major public health concerns and their unmet medical needs.
GENFIT's research programs have resulted in the creation of a rich and diversified pipeline of drug candidates at different stages of development, including GENFIT's lead proprietary compound, GFT505, that is currently in Phase II.
With facilities in Lille, France, and Cambridge, MA (USA), the Company has approximately 80 employees. GENFIT is a public company listed on the Alternext trading market by Euronext™ Paris (Alternext: ALGFT; ISIN: FR0004163111). www.genfit.com
Jean-François Mouney – CEO & Chairman of the Management Board
Ph. +333 2016 4000
MILESTONES – Press Relations
Bruno Arabian
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No JaVale McGee, no Nick Young, no Andray Blatche, no fun.
I saw Hicks on Twitter, talking about Lance's full-court pass. Anybody got video of it?
This space for rent.
In a couple years, though, I expect to see it.
This space for rent.
I still don't see where you get the doom and gloom from. Because people vent their frustrations? Don't see why you let it bother you that much. No doom and gloom on my side, but if the Pacers are playing bad, I think it's fair for anyone to call them out on it. This is a team that is supposed to be the 2nd best team in the East and when they aren't playing up to their potential, it is frustrating. Especially when the Heat are that much better now with Ray Allen. Pacers have to play 100 times better than they are if they want to have a shot with the Heat. I think it might be impossible, but the Pacers would get embarrassed if they played the Heat right now. I want them to get to a point where they'll play the best teams competitively. Hopefully these early season struggle will get the team to really focus.
First time in a long time, I've been happy with the team that was constructed, and now they struggle. I blame the coach.
First time in a long time, I've been happy with the team that was constructed, and now they struggle. I blame the coach.
Roy needs to try and dunk when he gets close to the rim. Some of the stuff he puts up in there is so soft. He also is catching the ball way too far out. If he can't get deep post position we shouldn't throw him the ball. Or if he gets pushed out, pass the ball out and repost. The guy throwing the entry pass cutting past him every single time is so predictable and almost never gives us a good look.
West had one of those games when nothing was going down, it happens.
Tyler is giving us some good energy and isn't trying to do things he can't do nearly as much.
witters: @imbtyler, @postgameonline
Wow, Tyler's steal + jam was sick.
Gerald Green 15 points and 8 rebounds finally looked comfortable.
I watched that 97/98 team. I knew that 97/98 team. The 97/98 team was a friend of mine. Heisenberg, this team is no 97/98 team.
I saw this as well during the game, he plays better offensively when he's attacking and not shooting large amount of 3s.
"Nobody wants to play against Tyler Hansbrough NO BODY!" ~ Frank Vogel
"And David put his hand in the bag and took out a stone and slung it. And it struck the Philistine on the head and he fell to the ground. Amen. "
Last night was a good opportunity to try a Hibbert-Mahinmi froncourt. West looked tired and had a cold hand and with Mahinmi and Hibbert me might have gotten some defensive stops.
sad but so true.
Glad to see Green finally have a good game. Hope that's the start of something.
Still not sure what the ultimate impact will be, because for every good shooting night and/or night where he goes uncovered for a good dunk or two, there's the questionable defense, handles, decision making. In other words, he can have decent stats, but in crucial situations, he's a turnover or mistake waiting to happen. But, hoping for some incremental progress in the Bball intangibles stuff.
Glad for a win. Liked Tyler's intensity and PG's shooting. Overall, though, not a confidence - inspiring performance. But, it was progress of sorts. So that's better than the previous several.
I'd rather die standing up than live on my knees.
-Emiliano Zapata
I was worried Vogel would make the same mistake and keep Green in at the end of the game. He just is too unreliable for that. Vogel left him in a little longer than usual because he was playing so well, so I can understand that. But he finally brought Lance back with 3 minutes left, and the ball was in safe hands and nobody was looking at cheerleaders on key defensive plays.
"Look, it's up to me to put a team around ... Lance right now." Kevin Pritchard press conference
My bad X2. First, it wasn't an original tweet of yours, it was a retweet from Peck.
Second, it wasn't full-court. Got it mixed up with a different one.
Originally Posted by El Peckbo
This space for rent.
Green's typically a fine on ball defender (especially on smaller guys). Off ball he's going to have his issues, mainly because he gets caught watching the ball far too often. I'd be the first person to tell you that he shouldn't be in for the last defensive possession.
Offensively he'll be fine as long as he isn't expected to create too much off the dribble. Run him off screens, post him up (would really like to see a few post ups called for him every game...), and spot him up from three and you'll end up with some efficient scoring once his jumpshot gets going again. Ask him to do too much and you're going to get a couple dumb turnovers.
A Gerald Green fan who now finds himself rooting for the Suns.
I couldn't watch the game, how did everyone play? who looked good and who looked bad, was D.J. Augustin bad again?
Good: Lance, Paul, Tyler, Gerald, Ian (Defining good as "helped the team" as opposed to detracting.
Bad: Roy, Augustin, David
Neutral: George Hill
DJ looked bad again. Hit a nice 3, missed another wide open one. Isn't moving the ball particularly well.
Tyler was aggressive, provided a much needed spark and forced the issue, racking up 11ish FTA's. Which, coincidentally, is 2 fewer than Roy has attempted ALL SEASON.
David couldn't buy a bucket. Got decent looks, just couldn't get them to drop.
George Hill was ok, wasn't looking to score early but ran the offense well. Did have a really sweet run of 6/7 straight points. Wasn't anything special, but certainly didn't hurt the team.
Gerald was a nice surprise, starting to look more comfortable on the offensive end. Really shoots a nice jumper coming off screens. Hit a clutch bucket late in the game.
"I think if he is and we pass on Leaf we'd be some dumb mother ****ers."
- Larry Bird to Kevin Pritchard before their pick on Draft Day
Two of the Pacers' recent second-round picks, A.J. Price and Lance Stephenson, started in this game (due to injuries to starters). I don't know what to make of that. Good drafting by the front office, I guess?
It would be nicer if Green and Paul had some of the same plays ran for them, involving off-ball double screens, and a decent backdoor cut. The Wizards were running double screens for Beal to get Lance off his back (which is saying a lot). Paul and Green don't do well with Granger's plays ran for them, because the plays are better for Granger's style of dribble-driving from the perimeter. Paul and Green can do that, but not as patented, and would be better going off screens, making backdoor cuts, and posting up. I'm not saying they can't perform at the perimeter like Granger; just that Granger's offensive skills revolve around that style, and Paul's/Green's offensive skills don't.
witters: @imbtyler, @postgameonline


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A RURAL watchdog claims its view the Government "should not be solely fixated" on broadband speed has been "vindicated" in a report by an independent think tank.
The Policy Exchange report, The Superfast and the Furious, states that the Government should focus on helping the 10.8 million people who are not online as well as helping small businesses make more of the potential released by the digital revolution.
Country Land and Business Association (CLA) head of rural development Dr Charles Trotman said: "We have long advocated a clearer Government focus on ensuring that all in rural areas have access to an affordable and effective broadband connection of at least two Megabits per second (Mbps).
"As we stated in our own policy statement, Broadband Fit For Growth, without universal coverage and the need for a universal service obligation, the rural/urban digital divide will simply be exacerbated. What is clear from the Policy Exchange research is that the majority of the British public agree with us.
"Around 20 per cent of those who live in rural England and Wales are still unable to receive anywhere near the Government's benchmark of two Mbps. There is still a huge amount to be done to ensure coverage is universal.
"We believe the Government must do more to help the countryside. By seeking to form a strategic alliance with other rural interest groups to agree common objectives, we can help to deliver a comprehensive broadband strategy."
The CLA is also calling on the Government to provide an appropriate framework, allowing rural communities to "piggy-back" on to public sector broadband which already exists in many rural locations, such as schools and libraries.
Dr Trotman said: "Until a fixed-line broadband infrastructure is put in place, other technologies must be used to bridge the rural/urban digital divide.
"The CLA advocates a patchwork-quilt model, whereby other technologies, such as wi-fi and satellite, become widely available and used but the Government must create the right conditions for this to happen."
The CLA wants local authorities to ensure contracts awarded to infrastructure providers include fair compensation provisions for any failure to meet time and coverage requirements.
Dr Trotman added: "We do not believe Broadband Delivery UK's bidding process is working. The system adopted by the Government is too bureaucratic and has discouraged many of the big market players from taking part.
"Moreover, payments to providers must be performance related to ensure a fast and effective broadband service is rolled out to rural areas."


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CEDAR GROVE - The Bullitt Cup will continue to reside in Mount Washington as the Bullitt East Lady Chargers kept their stranglehold on the award for the top girls' golf team in the county.
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(UPDATED COVERAGE, July 14) Sam Perricone, founder of Los Angeles-based Perricone Farms and other citrus-related businesses, has died. He was 91.
Frieda Caplan, founder and board chairwoman of Frieda's, said Perricone was a mentor to many in the business community.
"It was through one of Sam's many trading companies that Frieda's shipped the first container of kiwifruit to Japan," Caplan said. "There was no official trade at the time between Japan and New Zealand."
"Sam backed so many businesses," she said. "He's a legend in the industry. People would say, 'He helped me do this, he helped me do that.' Sam was everywhere and never turned anybody down. He was just one of those people."
Perricone, who died July 8, started his produce career selling lemons from the back of a truck.
By age 16 in the mid-1930s he was picking, packing and selling in the city's Grand Central Market. It was the first in a series of steps that led to the creation of Perricone Farms 60 years later, according to the company's website.
Perricone formed P&W Citrus with Warren Santino in 1938, and established Sam Perricone Citrus Co. in 1947. By the 1950s he owned thousands of acres of citrus groves.
Sam Perricone Citrus Co. was sold in 1998 to Fresh America Corp. Perricone remained active in it for a while. Fresh America closed the Los Angeles facility in 2000 as part of a reorganization, but continued in the citrus business as Fresh America Allied-Perricone.
In the early 1980s, Perricone acquired an extraction plant and moved into the fresh-squeezed juice business. Juices later became Perricone Farms' signature product.
His career was marked by enduring links to the Los Angeles Wholesale Produce Market. After the Fresh America acquisition, Perricone continued to work daily at the north-end office his produce operation had moved into when the new market opened in 1986.
This time he focused on farming operations and managing ranches for Sam Perricone Properties. Those lands produced about 1 million boxes a year in oranges, lemons and avocados, marketed by Sunkist Growers and Cal Flavor.
In 2002, he won the Spirit of Life award from the City of Hope hospital and cancer research facility in Duarte, Calif.
Perricone is survived by a sister, Mary Santoro; a brother, Tony Perricone; and by three children, Joe, Sam and Lucy. He also has 18 grandchildren, 34 great-grandchildren and two great-great-grandchildren.
"Sam Perricone will certainly be missed," produce marketing veteran Dick Keim said in an e-mail.
Memorial donations were to go to St. John of God, Los Angeles; the Villa Scalabrini Retirement Center, Sun Valley; or the Franciscan Renewal Center, Scottsdale, Ariz.
For more coverage on Sam Perricone, visit the Orange County Register.
(CORRECTION: This article originally contained an incorrect photo. The Packer regrets the error.)


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A Wynn on the Calendar
I'm looking to do a calendar option spread on Wynn Resorts (WYNN) in front of earnings -- a low-risk way to participate and sell some of the high premium (juice) built into the front strike.
Here's how I'm playing it: The February 1 130 call (expiring Friday) is loaded with premium, a 170 IV. Wynn earnings are this evening, so we expect that sort of high number. By contrast, the February monthly is considerably less, in line with historical averages (28). Wednesday, the Wynn February 1 130 call closed at 0.90, and it may be 1+ this morning. The February monthly 130 call closed at about 1.25 and may be 1.40....143 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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To register your business with the department, you must submit a Business Tax Application (BT-1). This allows you to set up the appropriate tax accounts for your business. Completing this application online helps reduce the time it takes to register with the Indiana Department of Revenue for various tax types.
Once your application is completed and submitted, the Indiana Department of Revenue will contact you within 48 hours regarding the status of your application.
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For more information about business taxes, visit the New and Small Business Education Center.


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|Ice, 2 pitches, 180'
|WI4 [details]
|Page Views:
|Submitted By:
|Kris Gorny on Mar 12, 2007
|Comments on Nightfall
|Add Comment
|Show which comments —
By kevin fox
From: parker
Aug 4, 2008
|180 feet and 2 pitches. wouldn't it be easier to just climb it in one pitch?
By Kris Gorny
Aug 27, 2008
|Kevin, because of the large bowl in the first one third of the climb, after the initial 30ft, it is actually easier to do it in two pitches. It is possible to do it in one pitch but that involves placing very long slings (so long that you could actually deck) at the start of the vertical section right after the bowl to avoid rope drag.
By mark55401
From: Minneapolis
Mar 14, 2012
|has anyone done this recently (i.e. in 2011/12)?
By Tradiban
Mar 14, 2012
rating: WI4
Yes, a few friends of mine did this last week. Reportedly still shedding some rock but the ice was overall in good condition. There's some pics from FBook I can steal for ya if that's what you want.
I did it in 2010 if pretty poor ice conditions but the real hazard was constant rock fall from the sides.
By Frankenheimer
Mar 15, 2012
|Tried to access this one via the private property west side of the river and it seems the two residents are not at all pleased with climbers that have been using that trail without permission. We spoke with each household on the driveway for half an hour but claims of climbers running off when questioned about going through their yards apparently leaving trash(which I doubt) has seemingly ruined this access point for everyone else. The man also stated that if he sees people going through he will call the cops so do know that...
By Ken G
From: farmington, mn
Jan 23, 2013
|Climbed Sunday Jan 20 2013. Great ice, a little thin at top but made interesting.
By Dan Kolar
Feb 10, 2013
|Climbed it on Friday, 2/8. Ice was great until the top, pretty thin, but climbable (not really protectable). Last 20ish feet is really unprotectable but climbs fine. We did have a dinner plate come down and hit my partner in the arm. Be sure you set up the second belay on the steep section to avoid this,...lesson learned. Because he wasn't able to climb I had to repel from the top to him so there are two v threads set up (one at 25 meter from top, the other 30M from bottom). I did drop a petzl screw from the top....my last screw,...so the top was interesting. We checked around at the bottom and didn't find it. If someone does find it, I'll be indebted to them if they're kind enough to let me know.
By Zach Chase
From: Duluth, MN
Dec 16, 2013
|Is anyone aware of the condition of Nightfall at this point?
By Lspade
From: Maplewood, MN
Jan 5, 2014
My climbing partner and I spent 4 days on the North Shore iceclimbing and backpacking. When we got back my partner decided to edit a video of the climb, check it out...
v- GoPro video of Night Fall
^- GoPro video of Night Fall
I hope you enjoyed it!


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Well, that marks you as more of an insider than me. I know most of the insider terms, but allusions Burlington Coat Factory still just baffle me. If there is cause for embarrassment to anyone, I apologize for mentioning it.Quote:
Originally Posted by Seth
Question: Would there be any value in a section in the FAQ about statistics and data? Folks tend to hate on stats pretty strongly, sometimes without know what what the stat purports to tell. We could explain the +/- and the PER for starters.


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Amit Yoran
President, RSA
As President, Amit Yoran is responsible for developing RSA's strategic vision and operational execution. Previously, he served as Senior Vice President of Products, where he provided leadership for RSA's product development and product management organizations. Yoran founded and served as the Chief Executive Officer of NetWitness, the market-leading network forensic product provider, which was acquired by RSA in 2011. In 2003 and 2004, he served as Founding Director of the US-CERT program. Prior to that role, Yoran was Co-Founder and Chief Executive Officer of Riptech, which was acquired by Symantec in 2002, and where he subsequently served as Vice President of Worldwide Managed Security Services. Yoran is a graduate of the US Military Academy at West Point and George Washington University.
Amit's sessions at Asia Pacific & Japan 2014
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Machu Picchu
13 Dec 2012 at 13:00
After a long hike emmaline ate delicious fish made by chef Jose. emmaline ate five pieces of fish :)
With emmaline
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Research Study for Children With Salt Wasting Congenital Adrenal Hyperplasia
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- How to Read a Study Record
The purpose of this study is to develop a more physiological approach to the management of children and adolescents with salt wasting Congenital Adrenal Hyperplasia.
We will administer the glucocorticosteroid via insulin infusion pump to see whether this treatment will improve the serum hormone concentrations.
|Adrenal Hyperplasia, Congenital
|Drug: Hydrocortisone sodium acetate
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Novel Therapeutic Modality for Congenital Adrenal Hyperplasia
- Serum 17-OHP concentration in the morning [ Time Frame: 11 days ]
- serum steroid hormone profiles [ Time Frame: 11 days ]
- serum blood glucose [ Time Frame: study days 2,3 and 11 ]
- serum sodium [ Time Frame: study days 2,3 and 11 ]
|Study Start Date:
|January 2007
|Study Completion Date:
|September 2008
|Primary Completion Date:
|September 2008 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1 (Hydrocortisone sodium acetate)
Subcutaneous administration of Hydrocortisone sodium acetate via insulin pump
Drug: Hydrocortisone sodium acetate
Subcutaneous administration of medication via insulin pump
Other Name: Solu-Cortef injection
Detailed Description:
The adrenal gland is a small organ of the body. It produces very important chemicals called hormones. One of these hormones, cortisol (the stress hormone) helps the body fight diseases. The other hormone is the aldosterone helps to maintain the normal amount of salt and water in the body. The third type of hormones are the androgens or male hormones, which cause some of the changes during puberty, like the growth of body hair and pimples.
The salt wasting Congenital Adrenal Hyperplasia or CAH disease is a disease of the adrenal gland. Patients with this disease cannot make cortisol or the aldosterone. As a result, their body cannot fight diseases and cannot keep normal amounts of salt and water in the body. At the same time, the gland makes too much of the male hormones, which is bad for the body because too much male hormone slows down growth, increases the growth of body hair, and causes pimples and abnormal period in girls.
Patients with this disease have to take medications every day. However, the treatment does not work very well, because usually the patients do not have the right amount of hormone in their body. Usually the body gets too much hormone right after taking the pills. A couple of hours later the body has too little of the hormones, because in the meantime the body gets rid of the medication.The healthy adrenal gland makes the hormones throughout the day in different amounts. The patients with this disease take the medication only a couple of times a day. They take the Florinef tablet once a day and the Cortisol tablet two or three times a day. The treatment that we use today by mouth cannot copy the natural hormone productions of the adrenal gland. Because of this it does not make much of a difference in the patient's life.
We would like to improve the treatment and find out the effect of a new treatment. In this study we will try to imitate the body's normal hormone production and will give the medication via an insulin pump to see if this treatment method will decrease the male hormones in the blood. This study will help us to develop a new and better treatment for children and adolescents.
|Ages Eligible for Study:
|3 Years to 18 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Children with salt wasting CAH otherwise healthy without other chronic disease
- Age: between 3 and 18 years of age
- Body weight 23 kg (50 lbs) or above
- Hemoglobin equal to or higher than 12 g/dl before the study
- Supportive family environment
Exclusion Criteria:
- Age less than 3 or older than 18 years at the time of study
- Other chronic disease
- Hemoglobin less than 12 g/dl
- Non-supportive family
- Allergy to local anesthetics
Criteria for study termination: If the subject's parents are unable to manage/operate the pump, the subject will be withdrawn from the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00529841
|United States, Texas
|BCM, Texas Children's Hospital Clinic and General Clinical Research Center
|Houston, Texas, United States, 77030
|Principal Investigator:
|Morey W Haymond, MD
|Baylor College of Medicine
|Responsible Party:
|Baylor College of Medicine
|ClinicalTrials.gov Identifier:
|NCT00529841 History of Changes
|Other Study ID Numbers:
GCRC # 0962 ( Other Identifier: Baylor College of Medicine )
|Study First Received:
|September 12, 2007
|Last Updated:
|September 10, 2015
Keywords provided by Baylor College of Medicine:
Salt Wasting Congenital Adrenal Hyperplasia
Subcutaneous Hydrocortisone
Additional relevant MeSH terms:
Adrenal Hyperplasia, Congenital
Adrenogenital Syndrome
Adrenocortical Hyperfunction
Pathologic Processes
Disorders of Sex Development
Urogenital Abnormalities
Congenital Abnormalities
Genetic Diseases, Inborn
Steroid Metabolism, Inborn Errors
Metabolism, Inborn Errors
Metabolic Diseases
Adrenal Gland Diseases
Endocrine System Diseases
Gonadal Disorders
Hydrocortisone 17-butyrate 21-propionate
Cortisol succinate
Hydrocortisone acetate
Epinephryl borate
Anti-Inflammatory Agents
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
ClinicalTrials.gov processed this record on September 21, 2017