text:
My website allows a Member to upload one Photo to his/her Profile, however I want to Approve/Decline each uploaded file before it appears.
When I display a Member's Photo on a page, I usually am grabbing other Member Details (e.g. Username, First Name, Location, Gender, etc) from the database. And since I am trying to avoid having to call a PHP Function - with another SELECT query inside of it - to grab the "member_photo" and determine whether it was approved or not, I am wondering if I can handle all of this logic in one query?
The logic of what I need to do is pretty simple...
For a given "member.id",
if "photo_approved" = TRUE
then return "photo_name"
else return "photo_pending_approval.jpg"
Is it okay to stick that "business logic" into my MySQL Query, or should I leave that to a PHP Function??
Well, I have some hot-head PHP Developers that say I am flat out wrong for doing that...
Care to expound on why it is okay?
I suppose this comes down to the whole debate of where you store "Business Logic".
If you did everything in MySQL and then switched to Oracle you'd feel the pain.
Then again, if you stored everything in PHP and switched to .Net the same thing would happen?
The only thing I can see, is that they always say the DATABASE is the "bottle-neck" on almost every system, so maybe that is why it is better to stick things in a PHP Function? :-/
there is a word for those types of developers, and that word is incorrect
also, LEFT OUTER JOIN and COALESCE are standard sql, so no worries if you switch to oracle
where would you store the business logic that an order has to be associated with a known customer (relational integrity, enforced by foreign key)
where would you store the business logic that a customer needs to be identified uniquely (entity integrity, enforced by primary key)
and the toughest question of all... where would you store the business logic that a product must have certain known attributes (tables with defined columns for specific items of data)
anybody that thinks you should do "all" business logic in the application (php) is fooling themselves, and you can verify this by taking the database away from them and telling them to implement with text files and excel sheets
as for the database being a "bottleneck" you might ask yourself which types of people encounter more bottlenecks -- developers who know what they're doing or developers who are, shall we say, uninformed about what business rules actually belong in the database
sorry, this sounded like a rant, didn't it
wasn't aimed at you, debbie
I don't understand the problem with using a conditional in php swapping the image. Much less intimidating for a designer who might need to change it. That is how I would handle it.
Using a switch(conditional) as shown isn't going to have any noticeable affect on query performance.
Well, since you are diving into SQL, please allow me to describe what I need to do again...
Scenario:When a Member uploads a Photo, I store the physical Photo in a directory on my webserver, and in my database I have the fields "photo_name" and "photo_approved" (default=0).
Usually when I grab a Photo, I need to grab other Member Info and would have something like...
SELECT username, online_status, photo_name, photo_label, first_name, location
FROM member
WHERE id=?;
So, in SQL, how would I say...
"When you query the database for DoubleDee's info (id=19), check to see if "photo_approved"==TRUE, and if it is, then return the "photo_name", otherwise return "photo_pending_review.jpg" so a dummy photo can be shown."
I have a PHP Function that does that, but the problem is I query the database once - like in the example above - and then I have to run a SELECT a second time in my PHP Function to do the search and conditional I just described. So you have 2 database hits for only 1 bang?!
I agree.
Well, I'm sure that is a complicated topic, and one no one can address without a specific problem, but I have heard that consistently over the years, making me at least conclude that database calls are expensive, so query wisely...
Oh, I know. And the 20-something year old punk, who has both enough naiveté and arrogance to fill up Texas makes me shake my head...
For my simple case, I think using the database or a PHP Function is about equal.
But I am on an eternal quest to learn how to do things multiple ways, and learn how to do things the best way possible, so that is why I am asking.
SELECT username
, online_status
, CASE WHEN photo_approved -- true
THEN photo_name
ELSE 'photo_pending_review.jpg'
END AS photo
, photo_label
, first_name
, location
FROM member
WHERE id=?;
note that in this simple case of columns in the member table, i too might use an application conditional
when photos are in a separate table, that's when i'd use a LEFT OUTER JOIN with COALESCE
As I have been typing, a little light went off in my head... (Although I still hope r937 show me a solution in SQL.)
I was complaining because I have a query like this...
SELECT username, online_status, photo_name, photo_label, first_name, location
FROM member
WHERE id=?;
And then my PHP Function is like this...
function validatePhoto($dbc, $photoName){
// Check for Image.
if (is_null($photoName)){
$safeImage = "NoImageAvailable_100x76.png";
// Build query.
$q1 = "SELECT photo_approved
FROM member
WHERE photo_name=?";
// Prepare statement.
$stmt1 = mysqli_prepare($dbc, $q1);
// Bind variable to query.
mysqli_stmt_bind_param($stmt1, 's', $photoName);
// Execute query.
// Store results.
// Check # of Records Returned.
if (mysqli_stmt_num_rows($stmt1)>0){
// Record Found.
// Bind result-set to variables.
mysqli_stmt_bind_result($stmt1, $photoApproved);
// Fetch record.
// ********************
// Return Photo name. *
// ********************
if ($photoApproved==1){
// Approved Photo.
$safeImage = $photoName;
// return $photoName;
// Pending Photo.
$safeImage = "PhotoPendingApproval_100x76.png";
// Record Not Found.
$_SESSION['resultsCode'] = 'FUNCTION_MEMBER_ID_NOT_FOUND_5001';
// Set Error Source.
$_SESSION['errorPage'] = $_SERVER['SCRIPT_NAME'];
// Redirect to Outcome Page.
header("Location: " . BASE_URL . "/account/results.php");
// End script.
return $safeImage;
}//End of validatePhoto
But I guess there is no reason why I can't just go update all of my queries in my web pages to be like this...
SELECT username, online_status, photo_name, photo_label, photo_approved, first_name, locationFROM memberWHERE id=?;
...so there is only ONE Database Call, and then my PHP Function just does the swapping of the "photo_name" as needed, right?
Correct. When photo has not been approved merely change the photo in php, simple.
debbie, did you miss post #7 or ... ?
Apparently it crossed in the mail.
I haven't seen anything yet.
Just spotted it now, after sitting back down at my laptop? (Is that even proper English?!) :-/
Wow, that is simple?!
So is that code something I can run through my Prepared Statement?
Or is that a "Stored Procedure"?
What exactly is it called?
And is that MySQL specific, or would that work in SQL Server or Oracle too?
Nope just standard SQL. It will work on both MySQL and Oracle. What won't work on both is IF() though supported by mySQL. Which is probably why r937 used a case statement instead – more portable. I really wouldn't worry about portability to much. Going from one db to another is always a major expense any way you slice it – developers might as well get a piece of the pie. Also, how often do you think your going to change database providers. Especially Oracle considering it has a hefty price tag.
What won't work on both is IF() though supported by mySQL. Which is probably why r937 used a case statement instead – more portable.
Duly noted.
I really wouldn't worry about portability to much. Going from one db to another is always a major expense any way you slice it – developers might as well get a piece of the pie. Also, how often do you think your going to change database providers. Especially Oracle considering it has a hefty price tag.
Just playing devil's advocate.
Thanks for the help, r937!! :tup:
I had no clue you could do that in SQL, and learned something new!!
Ironically, the consensus I am getting from others is that I should NOT be pre-screening Uploaded Member Photos, and should just trust people?! (:
So it is looking like this thread was for not, other than I learned something new in SQL!!
not naught
wanna see the COALESCE ?
Oops! (I knew that!)
Especially considering that not long ago you were just discovering how functions work, your analysis is very astute.
Given the choice to put your business logic in the DB or in PHP, I think neither is inherently better or worse than the other. My only advice is to be consistent. Try to mix-and-max as little as possible.
It's great that you answered your own question.
I have just one comment. When you said "update all of my queries," that set off alarm bells in my head. That probably means you should refactor to avoid repeating the same code. Maybe a function like getMemberById to write the query once and call it when you need it.
function validatePhoto($dbc, $photoName){
... // ******************** // Return Photo name. * // ******************** if ($photoApproved==1){ // Approved Photo. $safeImage = $photoName;// return $photoName; }else{ // Pending Photo. $safeImage = "PhotoPendingApproval_100x76.png"; }...
function validatePhoto($dbc, $photoName){
... // ******************** // Return Photo name. * // ******************** if ($photoApproved==1){ // Approved Photo. $safeImage = $photoName;// return $photoName; }else{ // Pending Photo. $safeImage = "PhotoPendingApproval_100x76.png"; }...
I'd actually suggest moving this kind of logic to the templating layer. The business logic only needs to answer: Is the photo approved? Then the templating layer gets to decide how to render that information -- maybe a simple message, maybe a popup notification, or maybe, like this case, a dummy image. But whichever you choose, it's still a templating decision.
assume the photos are in a separate table, members are allowed more than one photo, and you want to retrieve the photo that the member has marked as primary
SELECT member.username
, member.online_status
, COALESCE(photos.photo_name
, 'photo_pending_review.jpg') AS photo
, COALESCE(photos.photo_label
, 'Pending') AS photo_label
, member.first_name
, member.location
FROM member
JOIN photos
ON photos.member_id = member.id
AND photos.primary = 1
AND photos.photo_approved = 1
WHERE member.id = ?
this is good advice, except that certain business rules are inherently better in the database (see post #4) and should never be done with php


text:
Job Opportunities
Administrative Job Opportunities
Director of the Quantitative/Symbolic Reasoning Center
Hamilton is one of the nation's top liberal arts colleges. It is independent, highly selective, coeducational and residential. Originally founded in 1793 as the Hamilton-Oneida Academy, Hamilton is today composed of 1,850 diverse and talented students from nearly all of the 50 states and approximately 40 countries. More information can be found at www.hamilton.edu/about.
Hamilton College invites applications for a full-time academic-year director of its Center for Quantitative and Symbolic Reasoning. The Center provides resources and tutoring for students in courses designated as fulfilling Hamilton's Quantitative and Symbolic Reasoning requirement and for faculty teaching such courses. We expect the Director will also teach one credit-bearing quantitative skills course each year. We seek an engaging professional leader adept at working both independently and with multiple constituents on campus to provide superior academic support in the areas of quantitative and symbolic reasoning.
The Director oversees the daily operation of the QSR Center facilities and is responsible for recruiting, training, and supervising student tutors. In addition, the Director coordinates the Peer-Tutoring program for students enrolled in quantitative/symbolic courses as well as in courses in other areas of the curriculum. Other responsibilities include the development of tutorial materials, conducting faculty workshops on quantitative/symbolic reasoning in the curriculum, participation in professional communities, and publicizing the activities and resources of the QSR Center.
Experience in an administrative or leadership capacity, teaching experience, and an advanced degree in a quantitative/symbolic field required. Characteristics of a successful candidate may include a PhD. Equivalent combination of education and experience will be considered.
Please submit a résumé, cover letter, and the names and contact information of three references to email@example.com. Address questions about the position to Human Resources at (315) 859-4302. Review of applications will begin on May 13 and continue until the position is filled.
Hamilton (www.hamilton.edu) is a residential liberal arts college located in upstate New York. Applicants with dual-career considerations can find other Hamilton and nearby academic job listings at www.upstatenyherc.org. Hamilton College is an affirmative action, equal opportunity employer and is committed to diversity in all areas of the campus community. Hamilton provides domestic partner benefits. Candidates from underrepresented groups in higher education are especially encouraged to apply.
Please review Hamilton's Benefits Summary for more information.
Hamilton College is an Affirmative Action, Equal Opportunity employer and encourages diversity in all areas of the campus community.Posted 04/30/2013

subset: commoncrawl


text:
1-Octanol to Treat Essential Tremor
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- Disclaimer
- How to Read a Study Record
This study will determine the optimal dose of 1-octanol that will safely reduce tremors in patients with essential tremor-a disorder in which the hands, and sometimes the head, shake involuntarily. Current treatments may be ineffective or produce unwanted side effects. Ethanol (the chemical in beer and wine that causes intoxication) reduces tremor in many patients, but patients generally don't use it regularly because it interferes with daily activities. Laboratory studies show that 1-octanol, a drug that is similar to ethanol, may have the same beneficial effect on tremors with less likelihood of intoxication.
Patients 21 years of age and older with essential tremor may be eligible for this 10-day study. Candidates will be evaluated with a neurological examination, blood tests, urinalysis and electrocardiogram (EKG). Those enrolled will be admitted to the hospital for 4 days for 1-octanol administration and monitoring. On day 1, patients will have a medical history and physical examination. A catheter (a thin plastic tube) will be placed in a vein of the forearm for sampling blood. Patients will take one 1-octanol capsule (at one of seven doses) by mouth and will be monitored for tremors and drug side effects. Blood will be sampled periodically in the first 3 hours to determine 1-octanol blood levels. On days 2 and 3, patients will be monitored for additional side effects. On days 3 and 4, laboratory tests (blood and urine) will be done to evaluate liver and kidney function. On day 4, the catheter will be removed and the patient will be discharged from the hospital. A follow-up visit will be scheduled 1 week after discharge for a physical examination and blood, urine and EKG tests.
|Essential Tremor
|Drug: 1-Octanol
|Phase 1
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|Dose Finding Study of 1-Octanol in Essential Tremor
|Estimated Enrollment:
|Study Start Date:
|May 2001
|Estimated Study Completion Date:
|March 2004
Essential tremor is a very common movement disorder affecting approximately 1.4% of the population. Response to medications such as beta blockers and mysoline may be only partial or be accompanied by intolerable side effects. Roughly 80% of patients have significant tremor reduction to ethanol although daily use of this as a treatment has potentially serious social and legal consequences. The leading hypothesis for the pathophysiology of essential tremor is unmasking of spontaneous oscillation of neurons in the inferior olive. Both ethanol and 1-octanol have been shown to reduce these spontaneous oscillations in an animal model of essential tremor; however, 1-octanol dose this at a dose much lower than an intoxicating dose suggesting that it may be useful in the treatment of essential tremor. Our initial study with 1-octanol at a low, single dose in patients with essential tremor suggested it was both efficacious and safe.
This present study is planned to identify a maximum tolerated dose and broaden the safety and efficacy data in humans. Additionally, we hope to collect further information about the pharmacokinetics of 1-octanol. This study is designed as a phase Ia, unblinded, inpatient study of adults with essential tremor receiving escalating doses of 1-octanol. Cohorts of three will begin dose escalation at the dose previously studied. Each cohort will be followed in inpatient setting for 72 hours ( and outpatient for 1 additional week) during which adverse events, pharmacokinetics and efficacy will be assessed. If no subject achieves dose-limiting toxicity, 3 additional subjects will be recruited to receive the next higher dose. If 1/3 subjects achieves dose-limiting toxicity, the next cohort will receive the same dose. Dose limiting toxicity is defined as the dose that produces dose-limiting toxicity in at least 2 subjects. Maximum tolerated dose will be defined as the next lower dose.
With this study, we hope to identify a range of doses that may useful in the treatment of essential tremor and combined with the pharmacokinetic and efficacy data, design a protocol to study multiple dose regimens over longer time periods.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Patients with essential tremor with a history or ethanol responsiveness.
Patients must be off any medications used to treat essential tremor such as mysoline or propranalol for at least 2 weeks.
Patients must withhold ethanol and caffeine from 24 hours prior to starting the study until study termination (10 days).
Patients with abnormalities on neurologic exam other than tremor.
Patients with a history of chronic alcohol dependence.
Patients with chronic medical conditions such as renal failure, hepatic failure and chronic lung disease.
Patients on other chronic medications that cannot be temporarily discontinued for the length of the study (10 days).
Patients, who for moral or religious reasons do not wish to take a potentially intoxicating drug.
Patients with abnormalities on their baseline screening laboratory tests.
Women who are pregnant or lactating.
People of Asian decent who may differ pharmocogenetically with respect to alcohol and aldehyde dehydrogenase and may have increased sensitivity to alcohols and their metabolites
Please refer to this study by its ClinicalTrials.gov identifier: NCT00016679
|United States, Maryland
|National Institute of Neurological Disorders and Stroke (NINDS)
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00016679 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 24, 2001
|Last Updated:
|March 3, 2008
Keywords provided by National Institutes of Health Clinical Center (CC):
Side Effects
Essential Tremor
Movement Disorder
Additional relevant MeSH terms:
Essential Tremor
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Movement Disorders
Central Nervous System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Friday, September 22, 2017
Skin Care and Diseases
I can see some white patches on my leg and on the ear.
I`ve consulted few doctors who said there is no treatment, its immune system. Is there any treatment for this problem where it can be static rather than spread to other parts of the body? There are numerous web solutions, but i want to know which is the best.
please let me know, i would appreciate it
If it is vitiligo, your doctors are correct in that it has an underlying immunologic mechanism, and so reversing or curing is not easy. sometimes it is associated with another immune disease such as diabetes, thyroid disorders, and so proper work up needs to be done if such or similar diseases are suspected. I am hesitant to recommend anything on the internet as most of these did not undergo rigorous clinical testing.
Elma D Baron, MD
Associate Professor of Dermatology
Director, Skin Study Center
School of Medicine
Case Western Reserve University


text:
UI Board Chair Weighs in on University's Relationship with Businesses
The head of the University of Illinois Board of Trustees says higher education in the state must do a better job forging relationships with business and political leaders.
Board Chairman Chris Kennedy says in the two years he's been a trustee, the university has begun reaching out more to those in business and government. Kennedy is in charge of Chicago's Merchandise Mart. He says the U of I has to show the impact investments in higher education can make on the economy. He adds colleges and universities in Illinois have failed to successfully convey the message. Kennedy says too few business leaders even know the names of Presidents and trustees at the state's colleges and universities.
"Even if we could name them, we probably haven't received a call or opened an invitation from them to join in building a relationship with someone like Duck Durbin or Mark Kirk," Kennedy said. "These university leaders are not pushing the business leaders to become engaged with federal officials or to try to improve funding for the research institutions in our state."
Kennedy says that lack of coordinated effort has had a devastating effect on the ability to garner a larger share of federal research dollars. He made his remarks at the University' Springfield campus.


text:
Harp Guitar Ringer T-shirts are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Harp Guitar Ringer T-shirt for a special occasion, give a Harp Guitar T-Shirt as a present or need to represent with a funny Harp Guitar Ringer Tee during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Harp Guitar Ringer T-shirt for you! Even if it turns out you can't find the right Harp Guitar Ringer Shirt with the perfect design for your mother, father or children (or friends!); Idakoos offers all of its men's women's and children's Harp Guitar Ringer T-shirts as Custom Harp Guitar T-Shirts. Personalize any Harp Guitar Ringer T-shirt the way you want to ensure the perfect gift.
Showing 1 - 24 of 92 Ringer T-Shirt


text:
You are not logged in.
Forums are now closed as we moved them to google groups. You can use the following Google Groups to discuss about DebugBar and IETester products:
#1 2008-01-20 10:30:12
unable to view debugbar
I do not see the debug bar, not do I have an option to display this toolbar. I've tried versions 4 and 5, rebooting in between, with no positive results.
#2 2008-01-20 17:01:10
Re: unable to view debugbar
#3 2008-01-20 17:16:38
Re: unable to view debugbar
I am logged in as an admin.
#4 2008-04-07 03:27:24
Re: unable to view debugbar
Yes, I have
No, Only in View/Explorer bar
Windows 2000 SP4 + Russian MUI, MS IE 6.0.2800.1106 (Rus)
#5 2008-04-07 03:58:03
Re: unable to view debugbar
I see the debugbar as toolbar below IE menu, but nothing happens pressing the DebugBar button (that is, no DevBar).
#6 2008-04-07 07:44:55
Re: unable to view debugbar
@Vandal: There is a bug in DebugBar v5.0; This version needs gdiplus.dll for the toolbar component. I sent you the dll by email. This should correct your problem.
#7 2008-04-07 14:31:25
Re: unable to view debugbar
I also do not see Debugbar - anywhere. Installed/deinstalled it twice. XP sp2 IE6. Firefox is default browser. I have gdiplus.dll in system32 folder.
#8 2008-04-07 17:39:13
Re: unable to view debugbar
Re: DevBar not showing.
#9 2008-04-08 02:01:22
Re: unable to view debugbar
It's work!! Thanks a lot!!
#10 2008-04-08 09:39:39
Re: unable to view debugbar
@wysocki: That is really really strange. Do you see "DebugBar" entries in the "View/toolbar" or "View/explorer bar" menu ?
#11 2008-04-10 01:44:10
Re: unable to view debugbar
No enterprise anti-virus, just plain McAfee (and anyway, no warning of any kind).
#12 2008-04-10 18:18:42
Re: unable to view debugbar
Ahh! I still don't see anything in view/toolbar, but view/explorerbar DOES have it. And it works! Can't figure out why there's no toolbar though. In fact, I thought I would have also had an Acrobat toolbar there since I have Acrobat 8 full version installed, but it's not there either. What could cause blocking of toolbars being listed there?
#13 2008-04-14 09:36:05
Re: unable to view debugbar
@Max : If the "DebugBar" button is pressed, that is IE is reporting DebugBar panel opened. If you don't see it, I am really lost. If you have process explorer installed, can you check if "DebugInfobar.dll" is loaded into the iexplore.exe process ?
#14 2008-04-14 15:06:22
Re: unable to view debugbar
Just thought I'd chime in - I'm having the same problem as Max. That is, I press the DebugBar button and the DevBar doesn't show up. I'm running IE 7.0.5730.11 on XP SP2. I installed as local admin, but I'm running as an unpriveleged user. For what it's worth, a coworker of mine is doing exactly the same thing, except using IE6, and it works just fine. Our environments are exactly the same otherwise.
Last edited by bhagany (2008-04-14 15:10:51)
#15 2008-04-14 19:33:52
Re: unable to view debugbar
Looks like a non ending story.
#16 2008-04-14 20:31:45
Re: unable to view debugbar
Ah, yes, running as admin works. I'll use that as a workaround for now, but they kind of discourage that kind of thing around here. I appreciate you taking the time for a custom dll - let me know when you have a chance to get around to it.
#17 2008-04-14 22:13:55
Re: unable to view debugbar
Fine. I know what's wrong. Looks like registration is not working 100%. I will do some tests and try to correct the problem on a future release.
#18 2008-04-15 14:22:02
Re: unable to view debugbar
@bhagany : Can you try to install again DebugBar using your standard user account ? This may work.
#19 2008-04-18 02:00:05
Re: unable to view debugbar
Re: debugbar not showing
#20 2008-04-18 21:19:38
Re: unable to view debugbar
I'm always logged in as Administrator. IE6 under SP2 DOES have the manage add-ons and Debugbar was enabled. Although I had Acrobat toolbar also in the list, IT did not appear under the view menu either. As a test, I installed the Google toolbar then Debugbar and others suddenly were visible under the view menu. I removed the Google toolbar and everything else is still there. So it's fixed now, but I don't know why the toolbars didn't show up under view in the first place.
#21 2008-04-22 06:19:16
Re: unable to view debugbar
Re: my post of 2008-04-17, should have said "DevBar not showing".
#22 2008-04-22 06:28:50
Re: unable to view debugbar
Unfortunately, I don't have any ideas of what can cause the problem.


text:
Be careful near the monument — often home to a beehive.
Arroyo Seco Loop off Highway 79
The Canyoneers 1:30 p.m., Sept. 20
The San Diego Padres meet up with the New York Mets. Games broadcast on radio station XX Sports Radio (1090 AM), XEMO (860 AM) in Spanish. Tickets: 619-795-5000.
100 Park Boulevard, San Diego, 92101
Get directions
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text: I'm wondering, (not advocating) if there are teams who would like to have Roy! I like Roy, his d and his pr, however is it possible we trade him before the deadline? I realize he is having an issue with his hand/back spasms, and this question is not really about what we would get in return, but rather, is it wise to go a different direction now? We could manage without him and losing his contract would free us up for this summer. I think Ian M. could do just fine. Thoughts?


text:
Biomarker Discovery in Parkinson's Disease (DISCOVERY-PD)
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- Disclaimer
- How to Read a Study Record
There are approximately one million Americans who live with Parkinson's disease with 50,000 new cases per year and this rate is expected to rise with an aging population. The underlying pathophysiology and disease understanding of PD still remains elusive due to a combination of disease complexity and lack of predictive capability of existing models.
The Berg Interrogative Biology™ discovery platform has demonstrated a unique capability in producing drug targets and biomarkers that truly represent a disease phenotype. It has been able to catalyze molecules now in late stage clinical trials in cancer and many pre-clinical candidate therapeutics and biomarkers in endocrinology and central nervous system (CNS) diseases. The platform is able to decipher normal versus disease signatures by integration of data sets from the genome, metabolome, proteome, and lipidome in an agnostic manner that is subjected to Bayesian Artificial Intelligence informatics. The resulting nodes are then put back into wet-lab validation before proceeding to proof-of-principle pre-clinical testing.
By utilizing clinical data and specimens obtained by the medical specialists at The Parkinson's Institute, along with Berg's Interrogative Biology™, this study aims to discover a disease biomarker enabling the creation of a diagnostic test for Parkinson's disease.
|Parkinson's Disease
|Study Type:
|Study Design:
|Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:
|Proteomics, Metabolomics, Lipidomics and Genetic Analysis for Biomarker DISCOVERY in Parkinson's Disease
- Biological markers of Parkinson's disease [ Time Frame: 18 months ]To identify biologic markers of Parkinson's Disease (PD) for use in diagnostic testing.
- Correlation between biologic markers and clinical features of PD [ Time Frame: 36 months ]To identify and investigate possible correlations between biologic markers and clinical features of PD.
Biospecimen Retention: Samples With DNA
Blood & Urine Specimen Collection: Up to 20mL of venous blood samples will be collected for plasma multi-omic analysis, as well as optional genetic, analyses.
Urine samples (~50ml) will be collected via sterile urine cup and transferred into appropriate urine tube for multi-omic analysis.
All Samples may be saved for future studies, if consented.
|Study Start Date:
|December 2013
|Estimated Study Completion Date:
|June 2016
|Primary Completion Date:
|March 2016 (Final data collection date for primary outcome measure)
|Patients with Parkinson's disease
|Healthy Controls
|Ages Eligible for Study:
|18 Years to 90 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Inclusion Criteria:
For PD cases:
Inclusion Criteria:
- Men and women with the clinical diagnosis of idiopathic PD
- Willing and able to give informed consent
- Willing and able to comply with scheduled visits, required study procedures and laboratory tests
Exclusion Criteria:
PD Subjects with any of the following may not be enrolled:
- Presence of atypical or secondary parkinsonism
- Inability to provide a blood and/or urine sample
- History of renal failure and/or on dialysis
- Currently taking a medication in the following categories: dopamine blockers, neuroleptics, and/or dopamine blocking agents.
- Any medical, psychiatric or other condition which, in the opinion of the investigator, would preclude participation
Healthy Controls:
All of the following criteria must be met for a Healthy Control to be enrolled in the study:
- Healthy controls with no diagnosis of PD and any of the exclusion criteria
- Willing and able to give informed consent
- Willing and able to comply with scheduled visits, required study procedures and laboratory tests
Healthy Controls with any of the following may not be enrolled:
- No clinically significant or unstable medical or psychiatric condition that would interfere with the conduct of the study
- Diagnosis of PD or presence of signs of a neurodegenerative disorder, e.g. essential tremor
- First degree relative with PD/parkinsonism
- Inability to provide a blood and/or urine sample
- History of renal failure and/or on dialysis
- Any medical, psychiatric or other condition which, in the opinion of the investigator, would preclude participation
Please refer to this study by its ClinicalTrials.gov identifier: NCT02016092
|United States, California
|The Parkinson's Institute and Clinical Center
|Sunnyvale, California, United States, 94085
|Responsible Party:
|Birgitt Schuele, Associate Professor, The Parkinson's Institute
|ClinicalTrials.gov Identifier:
|NCT02016092 History of Changes
|Other Study ID Numbers:
5258 ( Other Grant/Funding Number: Berg Pharma, LLC )
|Study First Received:
|December 14, 2013
|Last Updated:
|March 10, 2016
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Plan Description:
|Individual participant data will not be made available, summary datasets may be published in peer-review journals.
Keywords provided by Birgitt Schuele, The Parkinson's Institute:
Parkinson's disease
Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
I can't handle all of these alts.
Van Hooligan X
4 time World Champion
Only 2 time dual World Champion
Won more awards than your best character has had #1 contender matches
APW co-founder
Hall of Famer
Most successful wrestler of all time
1 of the most successful managers of all time
Member of the greatest faction of all time (The Clique)
1/2 of the great tag team of all time (The Infection w/Carlos Alberto Ramon)
The destroyer of EFeds (w/Dennis)
1x Tag Team Champion - Ramon/Infection.
IWA & EWN Tag Team of the Year 2013 - Ramon/Infection.
1x Adrenaline Champion - Ramon.
HWA & EWN Champion of the Year 2012 - Ramon.
Feud of the Year 2012 - Ramon/Clique
Shocking Moment of the Year 2012 - Ramon/Clique
Feud of the Year 2013 - Rock/Ambrose.
Promo of the Year 2013 - Rock/Ambrose.
1x Women's Champion - Akira Tajiri
Female of the Year 2015 - Akira Tajiri


text:
the clip
should've been a jump ball
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should've been a jump ball
Something hillarious like this could only happen while the raptors were on the floor...they have trademarked hillarity with what happened with McGee on their floor. It may not always be their team but I am quite positive they are on the not top ten every week.
Getting caught up on some Dleague games while in class and my god is Kendall Marshall even worse than I projected(which was a 3rd string pg). Kid made a huge mistake coming out last year he should of went back to school like I said. He will be in the Dleague for a while.
I can watch John Jenkins play all day love watching that kid stroke the basketball. He vs Darius-Johnson-Odom was a good matchup to watch.
Yes he did but he was just missed at himself I think and it boiled over. He was playing awful and I think he wanted to go but Im sure the fine+ suspension he will get wont make him happy but he earned it.
Last edited by pacer4ever; 12-11-2012 at 01:54 PM.
Ben Wallace was OVERPAID! Talk about a GM blunder. It makes Walsh look like Exec of the Year material. Sometimes the best deal is the one you don't make, and this was one of Dumars better GM decisions.
I'd take Gasol in a heartbeat over Hibbert. I can't help but to believe Memphis would hang up the phone laughing if the Pacers FO called to trade Hibbert for Gasol.
I'd like to see what value other teams are willing to offer for Hibbert. Then I suppose it would depend on your definition of value.
Marc Gasol is on a whole different level than Hibbert. He's so much better it's barely a comparison beyond them both being centers who got the max. Bringing him up only illustrates that Hibbert is overpaid. I'm not sure Roy's mom would choose Roy over Marc.
Kevin Pelton @kpelton
Austin Rivers is on pace to rate 8.1 wins below replacement. -6.5 (Jason Collins, 2006-07) is the lowest mark on record.
glad my eyes don't lie.... I was saying he had to be one of the worst players in the league this year. I didn't like him coming out but damn he is even worse than I though he would be.
I love Austin Carr as the color man his style is just like Dirk's so LOL telling a story then BAM "KYRIE IRVING DEEP IN THE Q" talks so much trash but knows the game and is funny
Is it just me or is Kobe's defense really bad the last few weeks he doesnt look like the same Kobe on defense from last year. I don't know it seems Howard and Kobe have been not there normal self on defense. Howard is extra slow on rotations.
Sorry if I sound like a dumb *** here but...
What are "wins below replacement"?
Never heard of that advanced stat...
Nothing in life worth having comes easy.
Love drama
... and it goes on, and on, and on.In the end, Love never wants to feel like he's pitted against young point guard Ricky Rubio, because he adores him as a teammate and a talent. Yet, the reality is unmistakable: For all of Kahn's missed picks, failed signings and flawed trades, Rubio is the player whom the GM can take full credit. Someday, Kahn wants Rubio to be his five-year, max-out star, but will Rubio want to stay in Minnesota should Love walk out the door?
"It was a projection over a sure thing," Love says. "There's no question there was an agenda here. A different agenda."
"I have a very, very good memory, and I always remember the people who have done right by me, and the people who have done wrong by me," he says. "It will be embedded in my brain, and something I won't forget about. There's no telling what will happen. I would love to compete for a championship in Minnesota, but "
Love for Gasol to LA!
wins above replace is the wins above a replacement player basically a good Dleague player.
here is a better explanation http://sonicscentral.com/warp.html
I love A.C. He's clearly loves his job and has fun doing it.
this Brooklyn crowd sucks compared to last time
While Varejao has many fans within the Cavaliers organization, multiple league sources believe Cleveland will trade him as the February 21 trade deadline approaches. One league source thinks the Cavs would part ways with Varejao if they were able to add one or two more pieces to their young core that includes Kyrie Irving, Dion Waiters, Tristan Thompson and Tyler Zeller. HoopsWorld
One league source suggested that Varejao would be open to a trade rather than playing the best basketball of his career on a 4-17 Cavs team that seems poised for another trip to the lottery. At this point in Varejao's career, he likely wants to play for a contender, especially after getting a taste of deep postseason runs earlier in his career. HoopsWorld
I like that logic. Hard to trade a guy like Andy but if I was there GM I would trade him at the deadline in a heartbeat if they get fair value. His value will never be higher and he doesn't fit age wise with that team.
I just cant think of very many good trade partners off the top of my head.
EDIT: I think he would be a great fit for a team like the Lakers maybe a 3 team with Pau going elsewhere and young guys going to the Cavs from the 3rd team.
I dont know maybe Parsons and Patterson to the Cavs? Cavs need a wing like Parsons but I wonder if Morey would trade him for Pau I wouldn't if I was him.
Last edited by pacer4ever; 12-11-2012 at 10:17 PM.
I would give up a left nut for Andy on this team maybe them we can trade them Hibbert?
he is younger but does have an albatrossish contract
Counting down the days untill DJ Augustin's contract expires.
I would never want to engage in a sell low/buy high trade like Hibbert for Varejao. Roy will come around.
SA makes sense for Varejao, OKC makes sense too.
Man the Clippers are fun to watch.
Wizards turned down Brad Beal + Chris Singleton for James Harden. Owner didn't want to pay Harden. I like both those guys, but man that was stupid.
Talk about a natural backcourt for wall, harden call play off the ball and stroke it...
Don't get me wrong, Gasol is a great Center. But when Hibbert get off his offensive slump they are extremely comparable. I don't consider either one overpaid.
Re Hibbert and Gasol, Hibbert is better at rim protection, but that's about it. I wouldn't call him a better rebounder, this is more of a system thing - Hibbert and the Pacers focus on offensive boards, Marc Gasol rushes back on defense.
But the story also quotes an "official" who says it's not true and OKC asked for more. That seems likely, Beal and Singleton = pretty cheap, I'd say the Houston deal was better.
Last edited by hackashaq; 12-12-2012 at 12:27 PM.
I do agree they're comparable though. What Gasol is having is a better season. Doesn't mean he's "on another level."
Last edited by aamcguy; 12-12-2012 at 12:22 PM. Reason: weird floating I
Look at this reporter either not knowing Roddy was there, or just being a complete ***hole. Or kidding. I can't tell.
DG for 3


text:
The Future of Spirituality
Why It Must Be Integral
|Add to Cart
Self-Guided Video Course
Available immediately
100% guarantee on Sounds True titles
We unconditionally guarantee your satisfaction with all Sounds True products for one year when purchased via our website or catalog. If a Sounds True product fails to meet your expectations—for any reason—simply return it with receipt for a full refund. For items purchases from Sounds True, which manufactured by other companies, we indicate the warranty period in the product description.
Please note: Refund requests over 120 days from the purchase date will receive a check as funds cannot be returned to the credit card due to fraud protection policies.
All downloadable audio and video titles are also covered by a 1-year guarantee.
If the Buddha, Saint Theresa, or an enlightened shaman walked into the room today, would they find themselves in need of some serious spiritual catching up to do? The answer, says Ken Wilber, is yes. In this video teaching series, viewers explore the profound ways that spirituality is evolving today—and why it matters to all of us.
Integral evolutionary thinkers today are seeing a burst of accelerating shifts in human consciousness: in our emotional and cognitive lines of intelligence, our creative and moral capacities, our sense of self, and more. And as this landscape of knowledge grows, so does the potential of our own spiritual lives—in ways that even meditation and other inward practices alone cannot provide.
What is the evidence for this upward spiral in our spiritual intelligence? And if it's true, how do we experience these shifts directly, within ourselves?
The Future of Spirituality explores these emerging possibilities to help you discover their profound influences in your own life and in the world around you.
This candid, heart-to-heart conversation between Ken Wilber and host Tami Simon turns the spotlight to the ways that spirituality is evolving right now and why it matters to all of us on a meditative or contemplative spiritual path.
What You Will Receive
- Six Video Sessions—Join Ken Wilber, in conversation with Tami Simon, for six teaching sessions exploring how Spirit is now unfolding in the world and how to bring its emerging possibilities into your own life (6 hrs)
- Audio Q&A session with Ken Wilber (1 hr)
- Downloadable written study guide—Includes charts and illustrations of key integral maps
- Complete Downloads of the Teaching Series—The entire video series is yours to keep and enjoy as you widen and deepen your perspectives on the evolution of Spirit, the cosmos, and your own journey.
"The enlightened person of today and of 2,000 years ago are equally free," says Wilber. But now, for the first time in human history, we have the potential for a far more expansive, fuller spiritual experience than ever before possible. This is the territory that you are invited to explore, with The Future of Spirituality.
Join Ken Wilber in these intimate and lively video sessions as he delves deeply into many compelling topics, including:
- The core of integral spirituality: Spirit wants to evolve
- Waking up and growing up—two distinct and essential processes
- Freedom and fullness, the two dimensions of spiritual emergence
- How our place in history and culture shapes our deepest inner experiences
- How science and Western psychology are transforming spirituality
- Do all paths really lead to the same destination?
- Five states of consciousness: gross, subtle, casual, witness, non-dual
- If the Divine is formless and infinite, who needs levels and hierarchies?
- Enlightenment as a stage of development, not an event
- On reincarnation and life after death
- The shape of things to come: stages of spirituality yet to emerge
Session 1: The Two Truths: Emptiness and the Evolutionary Unfolding of Form
The series begins with an introduction to the two truths. Absolute truth, the realm of formless emptiness and oneness with the divine, was discovered by the great mystics over 2,000 years ago. Relative truth, our understanding of our minds and world, has accelerated only recently, in the past 200 years. In this session, Ken proposes that a complete spirituality requires the full embrace of both absolute and relative truth.
Session 2: Waking Up and Growing Up
From the integral evolutionary view, all spiritual paths have two dimensions: waking up and growing up. Here, Ken describes both. First, he addresses how we awaken into ever-deepening levels of consciousness (the gross, subtle, causal, witness, non-dual states) and leads us in a pointing out of these five states. Then he discusses the stages of growth that occur in the persistent, structural domains of our spiritual development.
Session 3: The Freedom and Fullness of Enlightenment
Ken provides here an integral definition of enlightenment. Drawing parallels to the process of becoming educated, he shows how the two concepts of waking up and growing up are reflected in the process of awakening: in the expanding freedom experienced as we move through the major states of consciousness, and in the increasing fullness we experience as we develop new stages of structure. Ken also explains the way that our stage development deeply shapes the way we interpret the mystical states that we experience in meditative and contemplative practice.
Session 4: Is Enlightenment All It Is Cracked Up to Be?
In this session, Ken describes how our understanding of intelligence itself has expanding beyond the early notion of a single IQ to one of multiple intelligences: emotional, moral, kinesthetic, musical, mathematical, spiritual, and more. Each of these lines opens the potential for areas of growth exclusive to each other—and uniquely shapes our spiritual unfolding.
Session 5: What Is of Ultimate Concern?
Our spiritual intelligence serves to answer the biggest of the Big Questions: What is of ultimate concern? In this session, Ken and Tami explore: why first-person experience is so essential to spiritual intelligence, how our individuality continues even as we touch the absolute and formless ground of pure being, and what mysteries human consciousness may never know. Here, Ken also shares his personal reflections on what happens when we die and the case for reincarnation.
Session 6: The Future of Spirituality
In this final dialog, Ken and Tami bring together the far-ranging topics of discussion covered in the series, with an emphasis on how to bring our rapid expansion of exterior knowledge and scientific understanding into practical use on our own spiritual paths. Ken describes the advantages of being a dual citizen of spirituality: practicing within a time-tested spiritual tradition while at the same time staying attuned to emerging insights.
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Write Your Own Review
Customer Reviews
- Review for The Future of Spirituality Review by Crista D
I have really enjoyed the conversations between Tammy and Ken. The content is very clear and easy to understand in spite of the complexity of the topic.
(Posted on 7/29/2013)
- Review for The Future of Spirituality Review by TIM H
terrific introduction to Ken Wilber for me
(Posted on 1/1/2013)
- Review for The Future of Spirituality Review by Patrick M
Excellent course.
(Posted on 10/23/2012)
- Review for The Future of Spirituality Review by Katherine Anne S
Ken's work is amazing. I really enjoyed Tami's questions and felt that I too, through her, could gain greater clarity on his amazing perceptions.
(Posted on 10/10/2012)
- Review for The Future of Spirituality Review by Katherine C
The course was excellent, absolutely priceless. I've been a student of Indian philosophy for over 35 years and a meditator for that long. Ken's course brought together my studies and practices in a very beautiful and comprehensive view as the evolution of spiritual thought. I better appreciate the spiritual and religious forces acting today here and now.
Previously I had no idea of the differences between waking up and growing up. After questioning and getting this, all kinds of memories came to mind of stories and interactions with fully/partially awakened beings - it all makes sense now.
About 15 years ago I uncovered Ken's books as was seeking answers to understanding the forces acting in our culture on a broader level. This course offered a leap forward in the whole of our society and the integral view - very powerful.
I further appreciate the more comlete and comprehensive view of multiple intelligences.
The clarity Ken presented on the three voices/persons really took hold as I reexamined the deep interest I have always had on ways of knowing.
And all of the above and more...yet the course is full of enjoyment and love...all at the same time! Thank you Ken. Thank you Tami. Thank you Sounds True.
(Posted on 10/9/2012)
- Review for The Future of Spirituality Review by Douglas W
I am enjoying the program quality and substance. More than that, I love this conversation between two of my favorite people.
I found that my understand is becoming clearer and I am more at ease sharing with others because of the greater clarity.
I have had some challenges downloading the large video files sometime taking up to 10 tries to get the whole thing downloaded using DSL.
For whatever the reason, I hope this aspect can be improved.
(Posted on 9/21/2012)
- Review for The Future of Spirituality Review by Laura B
(Posted on 9/5/2012)
- Review for The Future of Spirituality Review by Corey M
I never was contacted for this online program.
Has it happened yet?
Corey McMills email@example.com
(Posted on 9/2/2012)
- Review for The Future of Spirituality Review by Carol H
It hasn't happened yet.
(Posted on 8/19/2012)
- Review for The Future of Spirituality Review by Brudge Hopkins
Sounds like fun.
(Posted on 8/14/2012)
- Review for The Future of Spirituality Review by Surinder Deol
I listened to Ken-Tami audio CD collection "Kosmic Consciousness" and it changed me forever. It was a great gift of the Spirit. Ken and Tami on video -- I just can't wait to see that. Looks like a once in life time event.
(Posted on 7/25/2012)
- Review for The Future of Spirituality Review by John Sanders
Very much looking forward to this series. Watched the preview and its great to see Ken looking so well! Ironically, I'm working my way through the appendices of Integral Spirituality - Post Metaphysics, The Myth of the Given, which will be good background for this series. Thank you for this series!
(Posted on 7/10/2012)
- Review for The Future of Spirituality Review by Prof.Tomasz S.
Since 2,004 I practice 10 Minutes the wordless 'Key Meta-Rite'. It lets me daily," by mum body speech," to reach across the walls, beyond the blue sky and the Milky Way, the Big Bang over around into our common roots. In a jiffy. I bring back love, sense of self, creative and emotional capacities for every day. The Noah-Food, water and breath as Life Symbols of "Key" join me to all creatures on Earth. How does it matter? I'm sure in the video course "The Future of Spirituality" Ken's explanation lets deepen this rite 'we all can share' and give me the wise answer.
(Posted on 7/7/2012)
- Review for The Future of Spirituality Review by Ursula Altgassen
Only to see the preview I am on my knees with full heart and appreciation for the up lifting radical mapping of real updated spiritual truth in beauty.
I am deeply satisfied as a soul to take the teaching into life and world. Now is future.
(Posted on 7/7/2012)
- Review for The Future of Spirituality Review by Tom Carroll
"The Future of Spirituality" series is not available yet so these words are at best an expression of anticipation from a long time reader and listener. Given the depth and span of Ken's work - his unmatched ability to bring together such astonishing ideas, crossing time, culture and topical variety - and from these to synthesize and create not just novel, but world changing possibilities... Well, I'm looking forward with more than a little anticipation to having this new series on my iPod - right along with the first Ken Wilber. Tami Simon collaboration; Kosmic Consciousness. A Fie Star rating at this time might be over the top... but I bet I'm right!
(Posted on 7/7/2012)
Self-Guided Video Course
Contents Video download Date Published September 04, 2012 Product Code WC02919N


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Pantene Pro-V Restore Beautiful Lengths Shine Enhance Conditioner Reviews
Great for my hairI have thick, frizzly and dry hair. This conditioner helped my hair getting detangled easily, but the name "Time Renewal" is an oversatement. This does not actually "repair" damaged hair, it just makes my hair look better. I still recommend this product to those who have hair type like mine and who are looking for affordable moisturizing conditioner. — 9 years, 2 months agoluckybetty | 895 reviews
This review is: Helpful | Not helpful | Inappropriate | 0 of 1 people said helpful
Eventual Build-UpI have dark brown hair down to the middle of my back. It isn't chemically treated, but I seem to always have split ends due to daily blow outs and flat ironing. I like this product because I do feel like it leaves my long hair somewhat better protected than regular conditioner. Kind of coated in a way. I was told by a hairdresser once that Pantene tends to put silicone in their products and while ...read moreI have no real evidence that this is true, I wouldn't be surprised it was, especially for the restoratives collection. The main draw back to this product is that I feel about two weeks into using this conditioner I have major product build up, and it makes my hair more difficult to manage and kinda limp. At that point I have to do several washes with a clarifying shampoo to get back to basics. I will also add that I major issues with this one when showering with well water. My in-laws use well water, and after two uses of this at their house the build-up is super noticeable. My hair is dull, lifeless, and limp. I can only describe the scent of this conditioner as a 'clean, slightly sweet, producty' type smell, as it isn't at all fruity or floral. — 5 years, 6 months agoElphieGranger | 80 reviews
Yuck!I thought I would get something decent for the cost, however this dried my hair out. — 8 years, 8 months agoSwoldierGirl72 | 342 reviews
This review is: Helpful | Not helpful | Inappropriate | 0 of 1 people said helpful
Great at first...I was really happy with the results initially but my hair took a strange turn for the worse and started to look dryer and more damaged after a couple weeks. Not sure what happened but i won't be re-buying. — 7 years, 12 months agoluxylexi | 234 reviews
Fine hair, bewareI wish I'd read this site's review of this product before buying it. I have relatively long, fine, highlighted hair that I heat-style daily, so the prospect of repairing the damage I've caused seemed appealing. I should have thought about it a bit more. It's just a really rich conditioner that never quite feels 100% rinsed-out when you're done. It puts a coat on your hair. For someone who's perpet...read moreually trying to acheive more volume and encourage her stick-straight hair to curl at the ends, this was a bad choice. I can imagine that those who buy straigtening and frizz-control products would love this, though, so I won't rate it too harshly. — 8 years, 11 months agoamygab1126 | 242 reviews
I Second the EditorThis product is not nearly as magical as it claims. It left my hair oily, heavy and course. My usual conditioner, though pricey, leaves my hair silky soft. Also, this product cannot reverse hair damage. It can smooth and moisturize, but ask the pros- once you've got split ends the only way to 'heal' your hair is to chop them off. — 7 years, 8 months agoAmberDB | 189 reviews
Moving past the marketing materials for this...Regardless of what the company says about the product, this is a darn good hair repair conditioner. Sometimes the best you can ask for is no further damage, and this delivers that and more. My hair felt considerably more conditioned and easier to work with, and my hair is notorious for being difficult. Do I have proof that it "repaired" my hair? No. But it sure made it feel magnificent. — 7 years, 4 months agoRetrodiva | 159 reviews
heavythis product made my hair feel very heavy and came out as a baby blue color. — 7 years, 6 months agosupergirl50 | 6 reviews
A great boost for the fans who color their hair!I love to color my hair but sometimes the color becomes dull. This has helped bring out the shine in the color and also gives me unbelievably softness. The price is amazing for it's effects. — 7 years, 10 months agoKeoammara | 15 reviews
MehI didn't really like it. — 7 years, 10 months agoomeadhra | 58 reviews
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Kerrington Outdoor Patio Dining Set 7 pc.
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Set Includes:
Sit back and relax in style with the most durable, comfortable, and longest lasting patio set with the warranty to back it from LaZBoy® Outdoor Select.
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For additional questions or concerns regarding this product, please contact the Manufacturer's Customer Service Department at 1.866.851.3002
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Action Sling Dining Chair: L 34.5" x W 26" x H 40.75"
Stationary Sling Dining Chairs: L 34" x W 26" x H 41"
Dining Table: L 43.5" x W 84"x H 28.75"
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Fishburne Reloaded
Laurence Fishburne has been on camera since he was a boy. Now the man from the Matrix is playing Superman's boss and taking on Hannibal Lecter
Laurence Fishburne kicks back in a plush leather chair in Manhattan's Grand Havana Room, overlooking a northward view of the city encompassing Central Park and the Upper East Side. He lights a Cuban Quai d'Orsay ("A nice little Churchill," he says with satisfaction) and surveys his surroundings like visiting royalty, though it's really just one stop in a busy day. He's wearing an unstructured suit from Moshood ("Stevie Wonder wears their clothes, too," Fishburne notes), an Afrocentric boutique in Brooklyn's Fort Greene neighborhood. Loose-fitting, rough-woven and comfortable-looking, it's an eye-catching ivory with pinstripes in crimson and black crisscrossing to make a subtle windowpane plaid.
At the moment, Fishburne is that happiest of all thespians: a working actor. And not just working, but working every day, thanks to the rigors of a new TV series, "Hannibal," which joined NBC's primetime lineup in April.
Oh, and he's got a movie coming out in June, a little something you may have heard of called Man of Steel. He's playing Perry White, editor of the Daily Planet, where Clark Kent (a.k.a. Superman) works as a reporter. Fishburne is more than pleased to be part of what he and Warner Bros. hopes will be the first of a new series of Superman movies, kicked off by this summer's relaunch. He's got the fervor of a true fan.
"I'm a comic collector," Fishburne says. "I've got over 10,000 comics. I was mostly a Marvel guy growing up. But after Frank Miller's Dark Knight books, you can't ignore the Bat. And you can't ignore Superman either."
Man of Steel stars British newcomer Henry Cavill as Superman, with an all-star cast that also includes Russell Crowe, Kevin Costner, Michael Shannon, Diane Lane and Amy Adams. "It's an incredibly gifted cast," Fishburne says. He also has high praise for the film's director, Zack Snyder, the man behind the blockbuster hit 300 and Watchmen.
"Did you see his film Sucker Punch?" Fishburne says. "It was so awesome. A lot of people didn't get it, but I loved that film."
For his part, Snyder was excited to meet Fishburne, remembering the 1979 Christmas treat his father gave him: taking him to see Apocalypse Now on Christmas morning.
For his part, Snyder was excited to meet Fishburne, remembering the 1979 Christmas treat his father gave him: taking him to see Apocalypse Now on Christmas morning.
"He's amazing to work with," Snyder says. "I can't say enough awesome things about him. When you meet an actor that you admire, there's always that level of tension, like, will he be what I thought or will it be an illusion created by a role? But the meeting was better than I hoped. He's incredibly collaborative and smart. He's the professional's professional on the set—but he also has fun with it."
The Superman story has been transplanted from comic books to movie and television screens practically since the first Superman comic appeared in 1938. George Reeves wore the cape in the 1950s TV series, then Christopher Reeve embodied the transplant from the planet Krypton in the big-budget films of the 1970s and 1980s. But none of the subsequent Superman efforts, especially 2006's Superman Returns, have caught on with the type of impact delivered by films built around Batman and Spider-Man.
Man of Steel, Fishburne notes, offers a script and story by Christopher Nolan and David Goyer, who combined for the Batman trilogy that concluded last year with The Dark Knight Rises. Fishburne expects their effort to resonate with fans. "It's their treatment of this material. It will be quite different from that last one. It's a combination of the Superman origin story and the plot of the Richard Donner Superman [from 1978]."
Snyder cast Fishburne because "he has that cool guru quality. For Perry White I wanted, not necessarily a father figure, but someone who, when he told you something, that was it. And that's what Laurence is all about."
Fishburne's Perry White is "full of dimension, and not just barking at Lois Lane," Snyder says. "He's definitely a leader, he's physical. It's a cool evolution." Notes Fishburne's friend, filmmaker John Singleton, "Fish is a real geek. I think that, privately, he really loves playing Perry White."
As a collector, Fishburne is a connoisseur of comic-book movies. Even as he's hopeful as an actor that Man of Steel will spawn sequels, he's eager—as a fan—for a movie about the Justice League of America, the superhero team that includes Superman, Batman, Wonder Woman and a host of other heroes. Imagine the Justice League as the DC Comics answer to Marvel's The Avengers, the movie about Iron Man, Thor, The Hulk and other heroes that ranks as one of the top grossers of all time.
"They'd do well to make a Justice League movie," says Fishburne. "The Avengers was really good. I liked it better than all the movies that were leading up to it. The first Iron Man I really liked; Thor I wish I liked more."
Though he obviously fits the demographic, Fishburne has never made a trek to Comic-Con, the annual gathering in San Diego that's like Mecca for fans of fantasy, sci-fi, action, horror and comic books. Even before he was cast as Perry White, Fishburne was a legend among the sci-fi cognoscenti, having played the essential character Morpheus in The Matrix trilogy. He wouldn't get 10 feet on the convention-hall floor without being mobbed.
"I can't go and just walk around, I'm afraid," he says, sounding a bit wistful. "I have yet to go to Comic-Con, though I'm sure that, in the future, there will be a moment in time when I would go as the guy who played Morpheus."
Though he's been working in Toronto, Fishburne is in Manhattan to check in on his ailing father. He keeps a place in New York and is a member of the Grand Havana Room, where cigars are always welcome.
"I recently put down cigarettes," Fishburne says, "so I'm smoking more cigars. My go-to cigar is probably any kind of maduro. I like a dark, rich, sweet, mature cigar. I can't rattle off the names of brands I like. I do like that in Toronto I can get Cubans without having to go through 'channels.'
"It's very easy to smoke a cigar every day. When I said that to my doctor, he frowned. But my wife and my daughter don't give me a hard time. I take the cigars outside."
The Brooklyn native has lived in Los Angeles for a number of years, but now spends most of his time in Toronto, where he's been living with his wife, actress Gina Torres, and their young daughter since he finished his run on "CSI: Crime Scene Investigation" in 2011. The same year, Torres started production in Toronto on her USA Network series, "Suits," which recently finished airing its third season.
As Torres finished production of the latest season of her show, Fishburne began shooting his new one: "Hannibal," a new crime thriller for NBC, which debuted April 4. The series is a prequel to the Hannibal Lecter story, which began with Thomas Harris's 1981 novel Red Dragon. In that book Lecter, an imprisoned psychiatrist known as "Hannibal the Cannibal" for killing and eating several victims, played a large role in support of an FBI criminal profiler named Will Graham, who had come out of retirement to help find a serial killer known as the Tooth Fairy. One of the reasons for Graham's retirement? Just before he captured Lecter, he was nearly killed by the cannibal psychiatrist.
The new TV series starts before Lecter has been identified as a serial killer. In the show a young Will Graham (played by Hugh Dancy) is hired by the FBI due to his talents as a criminal profiler. But his new boss, Jack Crawford—played by Fishburne—has his doubts, worrying that Graham will need therapy to maintain his equilibrium given the intense nature of the work. So he hires a psychiatrist to help him—Dr. Hannibal Lecter, played by Danish star Mads Mikkelsen.
"My character heads the Behavioral Science section of the FBI who recruits Graham, because he has this incredible empathy," Fishburne says. "He's been recruited to catch serial killers because he can enter the emotional state of the killer. He can enter their minds; that's not a healthy thing to do. That makes him fragile—so my character enlists Lecter to counsel him, to be his therapist.
"It's actually very clever. You watch these three guys playing mind games. There are some horrifying images along the way, not all of them produced by Lecter. It's quite smart—very interesting. It's not a procedural —it's very much character-driven."
Bryan Fuller, executive producer of "Hannibal," says, "We were talking about who could play Jack Crawford. When Laurence's name came up, I wondered if we even dared to dream that we could get him. He's an iconic actor; you look at his résumé and there's one classic, distinctive film after another. And yet he'll do something quirky like play Cowboy Curtis on 'Pee-wee's Playhouse.' After the mere mention of his name, we couldn't think of anyone else being that character."
Bryan Fuller, executive producer of "Hannibal," says, "We were talking about who could play Jack Crawford. When Laurence's name came up, I wondered if we even dared to dream that we could get him. He's an iconic actor; you look at his résumé and there's one classic, distinctive film after another. And yet he'll do something quirky like play Cowboy Curtis on 'Pee-wee's Playhouse.' After the mere mention of his name, we couldn't think of anyone else being that character."
The Hannibal Lecter novels have all been adapted as films; the first one, Red Dragon, was made by Michael Mann as Manhunter in 1986, then as Red Dragon by Brett Ratner in 2002. Hannibal, the sequel to The Silence of the Lambs, was made in 2001 and Hannibal Rising followed in 2007. The most successful of all the film adaptations, The Silence of the Lambs swept the Academy Awards in 1992, winning Oscars for best picture, director, adapted screenplay, actor and actress.
So Fishburne is taking TV viewers into a familiar world, filled with characters that previously have been played by other actors. Will Graham was played by William Petersen in Manhunter and Edward Norton in Red Dragon, prior to Dancy's characterization on the TV series. Jack Crawford has been played by Dennis Farina, Scott Glenn and Harvey Keitel in various films. The connection to Glenn, with whom Fishburne worked as a teenager in Apocalypse Now, was particularly meaningful.
"I was talking to him about what we wanted to do, beyond what you normally see with this role in this kind of crime story," Fuller says. "We started talking about Scott Glenn. Laurence is a great raconteur telling stories about his career. He started telling me about working with Scott and how he looked on him as one of his 'uncles' on Apocalypse Now. His love of Scott and his affection for him was one of the things that impressed me, along with his passion for playing a role one of his 'uncles' had played. He wanted to make it his own and yet still honor what Scott—and Harvey and Dennis—had done."
The continuing public appetite for Harris' characters—especially Hannibal Lecter—is a cultural phenomenon that never seems to diminish. What is it about Hannibal Lecter in particular, and serial killers in general, that seems to appeal to the darker instincts of an audience?
"Everybody's dirty little secret is that we all, at some moment, fantasize about killing someone else," Fishburne says. "So Hannibal is the living embodiment of that fantasy. But it's meant as purely fantasy.
"Look at a show like 'Dexter.' I'm a huge 'Dexter' fan. Obviously, his being a serial killer is a metaphor for being different. But I wonder what it says that we've got this serial killer as our hero."
Fishburne can even tease out a connection between the world of Hannibal Lecter and that of "CSI," one of television's most popular long-running shows.
"Billy Petersen [who played Gil Grissom for almost 200 episodes of "CSI"] played Will Graham in Manhunter—and without that performance, I don't think there would have been 'CSI' as we knew it," says Fishburne. "That character was the prototype for what would become Grissom." And, of course, Fishburne, who is playing Will Graham's mentor in "Hannibal," replaced Petersen in "CSI" as Dr. Raymond Langston, an experience Fishburne says convinced him that a role in a quality TV series may be the best gig around.
"First of all, 'CSI' was incredibly convenient—five minutes from my house," he says. "And I got there nine seasons in, after all the heavy lifting had been done. They'd worked hard and built this well-oiled machine. All I had to do was enter and sit where the foundation had been laid. The best way for me to service the show was to fill the space. Because Billy was leaving a big hole."
So Fishburne is happy to return to the demands of a weekly hour-long crime drama. After three seasons on "CSI," Fishburne sees TV as the kind of job actors like best: one that requires them to be at the top of their craft on a daily basis. "TV gives me the opportunity to work every day," Fishburne says with barely contained joy. "There's an immediacy with television. You don't have to wait for it. I shot the Superman movie in, what, 2011? And it's not out yet.
"I just enjoy acting. I don't make a distinction between TV and film and theater. I enjoy them all. Really, the most interesting things being made, aside from documentaries, is the TV that's being done on cable. It's more interesting, really, than mainstream movies. Everything is remakes and sequels and tentpoles. And now reboots. And zombie movies."
Notes Fuller, "He's such a smart actor. He's that guy who's always thinking about where his character is at any given moment in that world. He's a storyteller as a human being; so he's an intuitive actor who is aware of the story being told."
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text:
Dear pāḷi friends,
I made a version of saṃyutta nikāya derived from the 5 vaggos of cst4, all jammed into one file, renumbered into the modern system.
Lots of hyperlinks, easy to navigate and get to the SN sutta you're looking for.
a link to the file here
Any bugs or comments, you can comment on the bottom of the webpage.


text:
I admit that I was T-I-R-E-D when I finally arrived home from work yesterday, but I was determined to finish what I started and let you know how my bread from Healthy Bread in 5 Minutes a Day turned out. I pulled out the whole wheat dough from our fridge and started reading through the directions for "Baking Day." I was disappointed to see that the dough had to rest for 90 minutes before baking; I definitely wasn't serving this along with dinner. With my husband craving fresh baked bread, no matter what time it came out of the oven, I went to work and formed my basic loaf according to the directions. This is what it looked like:
I let it be for 90 minutes at room temperature and it didn't really rise at all. I wasn't overly discouraged, as the book indicates that this might happen and did not direct me to put my bread in a warm area to rise.
I followed the directions (to the best of my ability) and this is what my loaf looked like when it came out of the oven. It's a bit on the small side, but not bad looking. If I had been a bit more vigilant, instead of getting sucked into a movie, it wouldn't have been quite so dark on top.
After letting it cool, we sliced into it and were impressed by the texture and crumb of the loaf. So far, so good, but the true test was how it tastes. It was fantastic! We loved the crispy crust and soft insides. Slathered with some butter and jam, it was delicious. Even though the loaf seemed smaller than anything I've ever baked- it was the perfect size for two of us.
What did I think? I think this book is a great companion to a busy life. Yes, you can have dough for four loaves ready in about five minutes and, more or less, throw it in the fridge until you're ready to use it. Yes, I can go home tonight and bake fresh bread, but it won't be ready for two hours. If I got home earlier, it would be a non-issue. Truth be told, that's really not too different from starting from scratch after work. I like the idea of this book and I'll probably keep using it, but if you're a really busy person and you want fresh bread STAT, hit the bakery on your way home to save time. The bread IS delicious and certainly less labor-intensive than other baking methods.
Bottom line: If you want freshly baked bread to be a part of your life, this book can save you time and produce great results… as long as you plan ahead.
The giveaway!
I have a signed copy of Healthy Bread in Five Minutes a Day to give away to one lucky reader! I'm also going to sweeten the deal with some Hard White Whole Wheat Flour and Vital Wheat Gluten (or gluten free flour and xanthan gum) to go along with the book. If you are gluten free, you're not left out! Zoë has recipes for applying this technique to gluten free breads; if the results are anything like what I created, you'll be a happy camper.
How to Enter: Leave me a comment here and tell me a little bit about your bread baking experiences/frustrations/tips and tricks/whatever. If you're just getting started on bread baking, tell me why you want to bake fresh bread (as if the smell isn't reason enough). I'll select a winner randomly from all comments submitted to my by 8 am on Monday, February 1st.
Bonus: More info and recipes for HB in 5 can be found here.


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Any person who is maimed or killed by a criminal suffers terror at some point. People who are carjacked suffer terror, wondering if they will be thrown out of the car or killed before the madman stops the vehicle. Children who are drowned by their parents, beaten to death by their parents, those who are in homes such as the family in Cheshire and are invaded, raped and burned to death are terrorized before their demise. I believe it is a slippery slope when someone, (only if they are an American), is not given due process after they commit a crime. If this is the future of America, then we no longer need judges, juries and Miranda rights in this country. We may be horrified at the destruction these people cause but this is the reason for the death penalty and prisons. If we do not uphold our justice system, we may as well start chopping hands off every time someone shoplifts a scarf. There is enough evidence, let the system work. Too bad that the feel-good liberals got rid of the death penalty in many states.
The officers who apprehended the Boston Bomber need to go back to the firing range. Now with the proposed civilian trial and all the advertisement that provides, the media will have a field day and invite more copy cats to join the fray. And lawyers will get rich.
RE: I'm always astounded: I hope Mayor Ryan Bingham, the City Council, Board of Public Safety , Board of Finance and all Torrington taxpayers, read the "I'm always astounded" post on this date!
Don't be fooled by "Mister East St. Louis". East St. Louis FD is NOT doing more with less. It is a city of 14 square miles (much smaller than Torrington) with a population of 27,000 people (less than Torrington). They are currently staffed at the same level as TFD and have have a similar budget. However, East St. Louis FD operates four firehouses, as opposed to the two firehouses that Torrington operates. Torrrington's number of fires does not compare with East St. Louis' in any way. That is true enough. However, TFD is able to operate in a much safer and efficient manner than East St. Louis. East St. Louis FD sends a minimum of two engine companies staffed with three firefighters (six firefighters) to each fire in the city, which is well below the number required by the NFPA.
There is no mention of a shift supervisor or a chief officer in their response, by the way. Torrington is able to send two engine companies (one with three firefighters and one with four), a ladder company (three firefighters), and an SUV with the shift supervisor (one person) to fires. This is granted that the fire is the only incident taking place at the time. That's a total of 11 personnel, which is the minimum shift staffing and also happens to be the consistant saffing level at TFD on a routine basis.If East St. Louis had one fire going, I'm sure they would send all four of their companies. Most fire departments in the United States respond with up to 5 engines, 2 chiefs and 15 firefighters (total of 17) to a house fire.
What astounds me, is that some people continually complain about the excellent fire service that their tax dollars provide them when they should be thankful that they have it in the first place, especially after hearing the stories of places like East St. Louis, IL. "Mister East St. Louis", I'm sure that city would love your addition to their poplulation and your tax contributions.


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Ruggiano, Polanco gets breather in finale
MIAMI -- A day after utilizing the same lineup in consecutive games for the first time all season, Marlins manager Mike Redmond gave a couple of guys Thursday night's series finale off to refuel.
Chris Coghlan started in center field in place of Justin Ruggiano, who was 0-for-7 on the homestand. Coghlan is tied with Eric Hinske for second in the National League in pinch-hits (six), including one on Wednesday night.
"[Ruggiano's] been in a little bit of a rough patch," Redmond said. "Get [Coghlan] in there. He's had some good at-bats off the bench and see if he can give us a little spark and go from there."
Nick Green earned the nod at third for Placido Polanco, who is 1-for-7 in the series. Polanco entered Thursday having started a team-high 36 of 40 games.
Redmond said he wants to keep his players fresh so they last the entire year.
"He just looked a little tired yesterday," Redmond said of Polanco. "I know we just came off a day off [Monday], but because of the situation with lack of depth, I've had to run him out there probably more than I anticipated."
Christina De Nicola is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Hibiscus Quilt + Sham
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- Overview
Create a tropical oasis for your favorite surfer girl with a garden of hibiscuses strewn across pure cotton percale.
- Made of 100% cotton percale.
- Filled with polyester batting.
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- Quilt and sham reverse to a pool blue.
- Quilted sham has an envelope closure.
- Twin-sized quilt fits both standard twin and twin XL dorm mattresses.
- Quilt, sham and insert sold separately.
- Machine wash.
- Imported.
Mix + match our bedding to create your own unique look with our Design Your Own Bed Tool.
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- Twin: 68" x 86"
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text:
Jamison Brewer OR Bruno Sundov supposedly have a chance of getting cut to make room for Eddie Robinson.
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Jamison Brewer OR Bruno Sundov supposedly have a chance of getting cut to make room for Eddie Robinson.
Yep, cause the NY media is always right.
I'll believe it when I see it. Bruno maybe, we all know he's worthless, but not Siggy. If they ever buy out Anderson, neither will happen.
Asked afterward if O'Neal's absence contributed to Charlotte's win, Knight bristled.
"What about Primoz? They didn't have Shaq, but we didn't have Primoz," he said.
Come to the Dark Side -- There's cookies!
I doubt Brewer will be cut.
Super Bowl XLI Champions
2000 Eastern Conference Champions
Or I meant Or....sorry
Brewer sucked in the limited pre-season minutes he got for the Knicks, and now is probbly providing the same role that he did for the Pacers, best dressed bench guy. His money with NY was garuanteed wasn't it? If so then its probbly the quickest few hundred grand he's ever made...presuming he gets cut that is....


text:
Late night...in a darkened high-rise office building in the heart of Manhattan...
MAN 1: Got a call from Stern today.
MAN 2: Yeah...
MAN 1: Thinks the Pistons could steal this one.
MAN 2: C'mon.
MAN 1: Really.
MAN 2: So what if they do.
MAN 1: America wants the Lakers to win. Stern wants the Lakers to win.
MAN 2: Right.
MAN 1: Plus a 7-game series means millions more in ad revenue. And it gets people interested in the NBA again.
MAN 2: I see.
MAN 1: So you know what you gotta do, right?
MAN 2: Send in Salvatore?
MAN 1: Send in Salvatore.
MAN 2: Pistons don't stand a chance tonight.
MAN 1: They never did. This is the Lakers year. One way or another.


text:
Cyclophil Me 25mg
Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release.
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Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release.
Cyclophil ME Capsule is used for Kidney transplantation, Liver transplantation, Heart transplantation, Rheumatoid arthritis, Psoriasis and other conditions.
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