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This information is of a general nature only and has been provided without taking account of your objectives, financial situation or needs. Because of this, you should consider whether the information is appropriate in light of your particular objectives, financial situation and needs. | This entry was posted on Tuesday, May 2nd, 2017 at 2:08 pm and is filed under . You can follow any responses to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.
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Controlling your Self Managed Super
Self Managed Super Funds (SMSFs) continue to grow in popularity. What is the large appeal that prompts so many people to go their own way despite all of the obligations and responsibilities of being a trustee – and being regulated by the Tax Office? … more
Are Your Inactive Bank Accounts at Risk?
We've all heard about the "lost billions" sitting in idle superannuation funds around Australia but are you aware of what's happening to hundreds of millions of dollars sitting in "inactive" bank accounts? Read on, you may be very surprised. … more


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A Phase 3 Study of SPL7013 Gel (VivaGel) for the Treatment of Bacterial Vaginosis
This study has been completed.
Starpharma Pty Ltd
Information provided by (Responsible Party):
Starpharma Pty Ltd
ClinicalTrials.gov Identifier:
First received: April 12, 2012
Last updated: October 27, 2013
Last verified: October 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The primary objective of the study is to assess the efficacy of 1% SPL7013 Gel compared to placebo gel for the treatment of bacterial vaginosis (BV).
After screening eligible participants will be randomized to receive either 1% SPL7013 Gel or hydroxyethyl cellulose (HEC) placebo gel at a dose of 5g administered vaginally at bedtime for 7 consecutive days. Participants will be assessed for BV (both by Amsel criteria and Nugent score) at screening/Baseline, after last application (End of Treatment, EOT, Day 9-12) and at the final study visit approximately 2-3 weeks after last dose (Test of Cure, TOC, Day 21-30).
|Bacterial Vaginosis
|Drug: 1% SPL7013 Gel Drug: Placebo
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Phase 3, Double-blind, Multicentre, Randomised, Placebo-controlled Study to Assess the Efficacy and Safety of SPL7013 Gel (VivaGel) for the Treatment of Bacterial Vaginosis
Resource links provided by NLM:
MedlinePlus related topics: Vaginal DiseasesU.S. FDA Resources
Further study details as provided by Starpharma Pty Ltd:
Primary Outcome Measures:
- Number of women with Clinical Cure at the Test of Cure visit (TOC) [ Time Frame: Day 21-30 ]Clinical Cure is defined as the resolution of clinical findings (ie Amsel criteria) from the Baseline visit (Day 1)
Secondary Outcome Measures:
- Number of women with Clinical Cure at the End of Treatment visit (EOT) [ Time Frame: Day 9-12 ]
- Number of women with Nugent Cure at the TOC visit [ Time Frame: Day 21-30 ]Nugent Cure is defined as a score of 0-3
- Number of women with Nugent Cure at the EOT visit [ Time Frame: Day 9-12 ]
- Incidence of adverse events [ Time Frame: Screening - TOC ]
|Study Start Date:
|March 2012
|Primary Completion Date:
|December 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: VivaGel
Drug: 1% SPL7013 Gel
Vaginal gel, daily for 7 days
Other Name: VivaGel
|Placebo Comparator: HEC Placebo
Drug: Placebo
Vaginal gel, daily for 7 days
|Ages Eligible for Study:
|12 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Key eligibility criteria:
- Post-menarchal females, aged 12 years or more
- Diagnosis of BV by Amsel criteria (ie all four of the following signs/symptoms: presence of white to grey homogeneous discharge; positive whiff test indicating an amine (fishy) odor with addition of potassium hydroxide; vaginal pH greater than 4.5; and presence at least 20% clue cells of total epithelial cells
- Nugent score of at least 4
- Otherwise healthy, as determined by medical history, physical examination
- normal Pap smear at or documented within 24 months of screening
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01577238
Please refer to this study by its ClinicalTrials.gov identifier: NCT01577238
Sponsors and Collaborators
Starpharma Pty Ltd
|Study Chair:
|Jeremy Paull, PhD
|Starpharma Pty Ltd
More Information
Keywords provided by Starpharma Pty Ltd:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Starpharma Pty Ltd
|ClinicalTrials.gov Identifier:
|NCT01577238 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 12, 2012
|Last Updated:
|October 27, 2013
Keywords provided by Starpharma Pty Ltd:
bacterial vaginosis
Additional relevant MeSH terms:
Vaginal Diseases
Vaginosis, Bacterial
Genital Diseases, Female
Bacterial Infections
ClinicalTrials.gov processed this record on September 21, 2017

subset: commoncrawl


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That is the worse I have ever seen a team get robbed. The way outside official makes a call to scrwe the nuggets in the last 24 seconds of the game that probably would have sealed it.
I just really wish the Lakers would cease to exist. I mean, they are the only thing wrong with the game. I don't know HOW Denver can have that travesty happen to them and go on the road trip they are about too.
This is the worse call I have seen, probably EVER!!!!
I am SOOOOOOOOO MAD!!!!!


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PLEASANT HILL — Citing a history of criminal activity linked to a former Blue Devils bingo parlor, the Planning Commission on Tuesday denied a use permit for a new parlor for the nonprofit youth drill team.
Tom Hope of Sacramento applied for the permit to open a nonprofit bingo parlor in the Country Square Shopping Center in the 500 block of Contra Costa Boulevard. The bingo parlor, which would have raised money for the Concord-based Blue Devils, was to be open seven days a week and until midnight on Friday and Saturday.
Hope previously ran a Blue Devils bingo parlor in the same building from 2004 to 2009. During that time, Pleasant Hill police received reports of thefts, assaults and other criminal activity related to the bingo parlor. Police urged commissioners to deny the use permit, citing similar reports linked to the Blue Devils' Concord bingo parlor.
If the planning commissioners had allowed Hope to withdraw the application — as he requested in a Nov. 7 letter to the city — he could have reapplied for a similar use permit at the same location without waiting at least one year.
Lisa P. White covers Martinez and Pleasant Hill. Contact her at 925-943-8011. Follow her at Twitter.com/lisa_p_white.


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I love this post from Heather Newton, author of Under the Mercy Trees, about Bibliofeast 2011, the National Reading Group Month event in Charlotte, NC last week. Read on to see why she enjoyed it so much and which other authors were featured at the event.
On October 10th, I had the pleasure of celebrating National Reading Group Month with the Charlotte chapter of the Women's National Book Association. For "Bibliofeast 2011" the Chapter invited me and eight other writers to a moveable feast. Maggiano's Little Italy Restaurant provided the feast (chicken piccata, ravioli, lasagne and chocolate cake--yum!). The authors provided the movable part, rotating among nine tables of participants to chat about books and whatever else came up in conversation. Sally Brewster, owner of Park Road Books ("Charlotte's Favorite Bookstore") was on hand to sell books.
Some guests were WNBA members, some came solo looking for a book club to join, some book clubs brought their entire group. The common trait? These people read. I was astonished at how many titles these ladies (and a few men) gulp down in a month. I came away with a great list of recommended reading.
Chapter President and event magician Susan Walker was nice enough to feed the authors before the participants arrived so our stomachs wouldn't growl during the event. Over the stuffed mushrooms I got to enjoy the company of Ellen Baker (I Gave My Heart to Know This), Ann Hite (Ghost on Black Mountain), Marjorie Hudson (Accidental Birds of the Carolinas), Valerie Nieman (Blood Clay), Michael Parker (The Watery Part of the World), Drew Perry (This Is Just Exactly Like You), John Milliken Thompson (The Reservoir) and Marybeth Whalen (She Makes It Look Easy).
During dinner a woman at my table asked me whether I enjoyed events like this. My answer: "Are you kidding me?" My daily life as a lawyer is adversarial, with clients in crisis and parties mad at each other. It was a real treat to spend an evening with happy people who love books as much as I do. My deep thanks to the Women's National Book Association for giving us National Reading Group Month!
Heather Newton's Under the Mercy Trees has been named a Great Group Read by the Women's National Book Association. See the complete list of Great Group Reads in honor of National Reading Group Month. Listen to Heather discuss Under the Mercy Trees here and check out the Under the Mercy Trees reading group guide. Visit Heather's website and friend her on Facebook. Look for more National Reading Group Month events throughout October here.


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Agile Open Northwest 2013
Agile Open Northwest
Wednesday, February 6, 2013 at 8:00 AM - Friday, February 8, 2013 at 4:30 PM (PST)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
Agile Open Northwest, a non-profit alliance of Agile practitioners in the US Pacific Northwest region, presents our seventh annual conference:
- What: An Open Space conference about Agile practices and techniques.
- Who: YOU and other experienced, collaborative, committed agile practitioners. Registration is limited to 150 participants.
- Cost: $200 for the three-day event, including continental breakfast and lunch each day, and dinner on the first evening.
Agile Open Northwest 2013 offers an opportunity to strengthen our community of practice and co-create the future for Agile development in our region. Over three days, we build on conversation after conversation as we engage important questions like:
What are the most important practices in making Agile approaches really successful on my team?
Who practices Agile philosophies, methods, principles or practices in the Northwest, and what's the impact?
What is the difference between Lean, Scrum, XP, and other Agile approaches?
What new technical challenges face Agile?
What are the latest cutting edge developments in the Agile software development world?
How do Agile frameworks and methods co-exist with project management, process control and other governance structures?
How do we adapt Agile practices to our organizations without diluting them?
Can Agile methods work in big, risky projects? How?
When distributed teams use Agile approaches, what changes?
If we adopt an Agile mindset, what might the transition look like in my organization?
This conference contains over 90 sessions bringing novices, journeymen, and experts together for face-to-face conversations exploring the most important topics in Agile software development today.
How does it work? Your hosts designed this event to allow practitioners like you to meet in self-organizing groups where we can share our latest ideas, challenges, hopes, experiences and experiments. We follow an Open Space format to foster collaboration and allow the conference to take its direction from the participants themselves. Your commitment to arriving at the beginning and staying until the end will ensure that session after session will integrate, enhance, and deepen every participant's understanding of achieving "Agile for Real."
When & Where
Ambridge Event Center
1333 NE Martin Luther King Jr Blvd
Wednesday, February 6, 2013 at 8:00 AM - Friday, February 8, 2013 at 4:30 PM (PST)
Add to my calendar
Agile Open Northwest
Agile Open Northwest is a non-profit alliance of Agile practitioners in the US Pacific Northwest region that has hosted since 2007 Open Space events each year, alternating between Portland, Oregon and Seattle, Washington.


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Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies (DEMENSTIM)
This study is currently recruiting participants.
Verified December 2016 by University Hospital, Rouen
University Hospital, Rouen
Information provided by (Responsible Party):
University Hospital, Rouen
ClinicalTrials.gov Identifier:
First received: April 5, 2011
Last updated: December 6, 2016
Last verified: December 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Deep brain stimulation has been developed as a substitute for the classical lesioning methods previously used in stereotactic and functional neurosurgery. Recent, anecdotal cases reports suggested that electrical stimulation of the cholinergic output of the Nucleus Basalis of Meynert (NBM) may improve cognitive performances, especially the memory tasks.
The present study aims to assess the effect of bilateral electrical stimulation of the NBM on the mnesic performance [assessed by the sum of the three free recalls of the Free and Cued Selective Recall Reminding Test (FCSRT)] in patients diagnosed with probable, moderate, Dementia with Lewy Bodies.
|Dementia With Lewy Bodies
|Procedure: Electrical stimulation of the nucleus basalis of Meynert
|Phase 1
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|Effects of Nucleus Basalis of Meynert Area Electrical Stimulation on Cognitive Behavioral Disorders in Dementia With Lewy Bodies : A Pilot Phase 1 Study
Resource links provided by NLM:
MedlinePlus related topics: Dementia Lewy Body DiseaseU.S. FDA Resources
Further study details as provided by University Hospital, Rouen:
Primary Outcome Measures:
- free recalls of the FCSRT [ Time Frame: between the assessments (Month 7) and (Month 10) ]The primary endpoint of the study is the difference in the sum of the three free recalls of the FCSRT between the assessments (M7) and (M10), i.e. the comparison of the performances with and without NBM electrical stimulation.
Secondary Outcome Measures:
- performances on different tests [ Time Frame: different tests recorded at Month 7 and Month 10 ]Comparison will be made between the performances on different tests recorded at M7 and M10, to evaluate the effect of bilateral electrical stimulation of the NBM on cognitivo-behavioral disorders.
|Estimated Enrollment:
|Study Start Date:
|October 2012
|Estimated Study Completion Date:
|October 2017
|Estimated Primary Completion Date:
|October 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
Sham Comparator: Sham Electrical stimulation of the nucleus basalis of Meynert
Deep brain stimulation
Procedure: Electrical stimulation of the nucleus basalis of Meynert
Differents parameters will be assessed.
Experimental: Electrical stimulation of the nucleus basalis of Meynert
Deep brain stimulation
Procedure: Electrical stimulation of the nucleus basalis of Meynert
Differents parameters will be assessed.
|Ages Eligible for Study:
|18 Years to 75 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of probable Lewy-body dementia according to the internationally accepted consensus criteria (McKeith, 2005)
- Outpatients, male or female, aged between 18 to 75 years
- Moderate dementia defined by a mini-mental state examination (MMSE) score between 16 and 26
- Stable dose of cholinesterase inhibitors (maximal dose tolerated) for a minimum of 1 months
- Patients receiving antiparkinsonian treatment unmodified for 3 months, if treated
- French as native language
- Written informed consent of the patient
- Written informed consent of the caregiver
Exclusion Criteria:
- Other causes of dementia (Alzheimer dementia, vascular dementia, dementia associated with Parkinson's disease)
- Other causes of extrapyramidal symptoms (Parkinson's disease)
- Patients with a history of severe psychiatric disorders, such as psychosis. Earlier episodes of depression and/or anxiety without hospitalization are not exclusion criteria
- Contraindications for MR imaging (claustrophobia, metallic foreign bodies, pacemakers, etc)
- MRI evidence of cerebral microbleeds
- Surgical contraindications: especially, hemostatic disorders, severe cortical atrophy
- Patients receiving treatments that may interfere with the cholinergic system: anticholinergics, cholinomimetics.
- Patients receiving neuroleptics
- Patients with a history of alcohol or drug abuse
- Pre-existing structural brain abnormalities (such as tumor, infarction, or intracranial hematoma)
- Previous neurosurgical intervention
- Patients with a progressively fatal disease, or life expectancy £ one year
- Asthma
- Severe visual deficit of ophthalmic origin (such as glaucoma, age related macular degeneration, cataract)
- Fertile women not using adequate contraceptive methods
- Women who are pregnant or breast feeding
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01340001
Please refer to this study by its ClinicalTrials.gov identifier: NCT01340001
|Contact: David MALTETE, MD, PhD
|(0)232888037 ext +33
|Maltête David
|Rouen, France, 76031
|Contact: David MAltête, MD,PhD 0670075564 firstname.lastname@example.com
Sponsors and Collaborators
University Hospital, Rouen
|Principal Investigator:
|Olivier GODEFROY, Md, PhD
|University Hospital of Amiens
|Principal Investigator:
|Luc DEFEBVRE, MD, PhD
|University Hospital of Lille
|Principal Investigator:
|HOUETO Jean-Luc, MD, PhD
|University Hospital of Poitiers
|Principal Investigator:
|Pierre Krystkowiak, MD, PhD
|University Hospital of Amiens
|Principal Investigator:
|Vincent Delasayette, MD
|University Hospital of Caen
More Information
Keywords provided by University Hospital, Rouen:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|University Hospital, Rouen
|ClinicalTrials.gov Identifier:
|NCT01340001 History of Changes
|Other Study ID Numbers:
2011-A00387-34 ( Other Identifier: ID-RCB )
|Study First Received:
|April 5, 2011
|Last Updated:
|December 6, 2016
Keywords provided by University Hospital, Rouen:
Dementia with Lewy bodies
Nucleus basalis of Meynert
Deep brain stimulation
Additional relevant MeSH terms:
Lewy Body Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
Parkinsonian Disorders
Basal Ganglia Diseases
Movement Disorders
Neurodegenerative Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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11 Concept Cars That Should Have Made It
When: late 2012
It's the least expensive 2013 BMW, period (but barely). The X1 is already out in other markets, and it's been a hit. No wonder: It's basically a shrunk-down X3 at a roughly $5,000 discount. Think 128i sedan with a hatch and more ground clearance and you've got the picture.
And guess what: It's really a BMW, complete with rear-wheel drive in the base model. Practically anything else for sale here that you could reasonably call a "crossover" defaults to front-wheel drive, which is far less sporty.
The RWD model gets BMW's workhorse 2.0-liter turbocharged four, here good for 241 hp and 260 lb-ft of torque. You can get the 2-liter mated to AWD too. The optional motor (AWD only) is BMW's creamy-smooth inline six 3.0-liter, good for 300 hp and 300 lb-ft. With either engine, the transmission is an eight-speed auto.
Price: starts at $31,500
When: The Sport is out shortly; the LWB debuts at the end of 2012.
A lot of carmakers lately are trying to cram third rows into the backs of crossovers that were originally designed for five passengers. Even if kids can fit back there, it's no fun, nor is extracting them from nosebleed-seat purgatory.
Hyundai, bucking that trend, will offer two Santa Fe models, the five-seat Santa Fe Sport and the LWB Santa Fe with seating for seven. And the latter doesn't just throw a third bench into the cargo hold. Hyundai actually stretched the wheelbase by 4 inches, adding more room to both the second and third rows. The new crossover is made of more high-strength steel, which cut some weight from the five-passenger and should result in better handling.
The five-passenger Santa Fe can be had with a 190-hp direct-injected 2.4-liter four, or the turbocharged 2.0-liter four with 264 hp. That's slightly less potent than the V-6 it replaces, but Hyundai is betting on a big improvement in fuel economy. The seven-seater big boy will be driven only by the 290-hp V-6 from the Hyundai Azera Sport. Yes, you can pair either model with AWD, but it costs more.
Price: starting at $25,275
10 Things You Didn't Know About Semi Trucks


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Fighting for Better Medicaid Drug Coverage
The S.L.E. Lupus Foundation once again joined many other patient groups in the "I Am Essential" coalition to submit this letter urging the Secretary of Health and Human Services to revise the final rule on prescription coverage for the expanded Medicaid program.
The plans must cover the 10 Essential Health Benefits described in the Affordable Care Act. However, the final rule from the Centers for Medicare and Medicaid Services (CMS) limits drug coverage by requiring plans to cover only the greater of one drug per class or the same number of drugs as contained in each class of drugs in the state selected benchmark plan. Historically, Medicaid beneficiaries have been able to access all drugs manufactured by companies participating in the drug rebate program. The final rule is a departure from the proposed rule and will provide beneficiaries in the expanded Medicaid program with a limited number of drugs, potentially putting their health at risk. The letter requests reconsideration of this rule and close monitoring for the expanded Medicaid program.


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Canada enjoys excellent relations with Estonia. Canada never recognized the Soviet occupation of the Baltic states and was one of the first countries to recognize the restoration of Estonia's independence in 1991. In 2004, Canada was also the first NATO country to ratify Estonia's accession the organization. Canada is also the home to the world's second largest Estonian community outside of Estonia, estimated at 24,000 individuals. The active Estonian-Canadian community underpins the countries' dynamic bilateral relations. Recent high level visits have included that of Estonia's Minister of Foreign Affairs Urmas Paet, who met with former Minister of Foreign Affairs Lawrence Cannon, former Minister of International Trade Peter Van Loan and Minister of National Defence Peter MacKay in November 2010. Former Minister Van Loan also visited Estonia in July 2010. In November 2011, the chairs of the Foreign Affairs Parliamentary Committees of Estonia, Latvia and Lithuania visited Ottawa to mark the 20th anniversary of the re-establishment of diplomatic relations between Canada and the Baltic states.
Canada and Estonia signed a Youth Mobility Agreement that was ratified in August 2010.The objective of this agreement is to promote the mobility of young Canadians and Estonians through new work and travel opportunities. Under this agreement, young adults between the ages of 18 and 35 can easily obtain a work or residence permit to engage in short-term employment in the other country. Canada and Estonia also signed a Social Security Agreement that came into force in November 2006.
On October 31, 2007, the Canadian government announced that citizens of the Republic of Estonia no longer required a temporary resident visa to visit Canada.
Canada and Estonia are NATO allies and both participate in the ISAF mission in Afghanistan. Canada has provided Estonian military officers with English and/or French language training, peacekeeping skills and other types of professional development support. Canada has been sending officers to attend the Baltic Defence College in Tartu, Estonia and has been providing the institution with lecturers and course development assistance since 2001. Canada also attended the NATO Foreign Ministers' Meeting in April 2010, as well as the NATO Parliamentary Assembly Spring Session in 2012, both held in Tallinn.
Primary Canadian exports to Estonia include machinery, lumber, toys and seafood and fur products. These exports totaled $22.9 million in 2012. Canada mainly imports telephone sets, mineral and chemical and food products, as well as fishing articles. These imports totaled $48.4 million in 2012.
Last updated: March 2013
* If you require a plug-in or a third-party software to view this file, please visit the alternative formats section of our help page .


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Can't compare Wallace and brown. But I love the effort from brown. If wallace had that level of effort he'd be unstoppable
Two things need to be said here. First I dont ever remember anyone on this forum ever saying Mike Wallace deserves Larry Fitzgerald money. The only one who I remember saying that is Mike Wallace. Saying the Steelers need to lock up Wallace to a long term contract worthy of being paid what he is worth isn't anything close to saying he deserves Larry Fitzgerald money.
Secondly, did anyone not see the game replays where Wallace was being held several times? It was pretty obvious and it was several times.
Steelers 2015 Draft???....Go Freak! As in....
1-Bernardrick McKinney MLB Mississippi State 6 ft 5 250 4.5 40 yard dash
wallace never said anything about wanting fitz money.
He nor his agent said that, the media did. And people here trust the media. Wallace also tweeted after that not to believe everything that you hear...
Steelers 2015 Draft???....Go Freak! As in....
1-Bernardrick McKinney MLB Mississippi State 6 ft 5 250 4.5 40 yard dash
I love Wallace, and I want him on this team - but I no longer believe that he is more valuable to this team than Brown.. So the idea of him making more than Brown seems a bit off.. Imho
I hated his effort today especially considering how tight "& important" the game was.. Heck since he has been getting "Double teamed" his effort seems to have dropped way off.. at least that's how it appears.. I hope today was just a bad one, I hope he picks it up, I am sure he will especially after the watch the tape but today was lousy.. Cant defend a guy who doesn't look like he is giving the effort.
When you have a player that makes your team significantly better than when you don't have him- what's his value?
Schiavone's Race Career:
Starts- 10
Wins- 2
2nd- 4
3rd- 0
Other- 4
Prizemoney- $60,050.00


text:
Coordinator: Richard B. Marsolek
Environmental Health & Safety
126 Bangsberg Hall
1500 Birchmont Drive NE #16
Bemidji, Mn 56601-2699
Office: (218)755-2545
President Les Duly established the Bemidji State University Environmental Task Force (ETF), in October 1992. The Task Force included individuals appointed by Dr. Duly and representatives from student, faculty, and staff organizations on campus. The Task Force was charged with making recommendations to the University Cabinet, on pertinent environmental issues including, but not limited to, University policies and practices for procurement, waste reduction, recycling, energy use and conservation, and heightening environmental education and awareness. In 1996, President Jim Bensen established the Environmental Task Force as a permanent, standing committee. The Task Force was renamed the Environmental Advisory Committee (EAC) in 1997. In 1998 it adopted a set of by-laws that includes broadened membership.
Go to the Environmental Advisory Committee's Minutes.


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Security as a Service Working Group
Introduction to the Security as a Service Working Group
The mission statement of the Cloud Security Alliance is ". . . to promote the use of best practices for providing security assurance within Cloud Computing, and provide education on the uses of Cloud Computing to help secure all other forms of computing." In order to provide greater focus on the second part of our mission statement, the CSA is embarking on a new research project to provide greater clarity on the area of Security as a Service.
Numerous security vendors are now leveraging cloud based models to deliver security solutions. This shift has occurred for a variety of reasons including greater economies of scale and streamlined delivery mechanisms. Regardless of the motivations for offering such services, consumers are now faced with evaluating security solutions which do not run on premises. Consumers need to understand the unique nature of cloud delivered security offerings so that they are in a position to evaluate the offerings and to understand if they will meet their needs.
The purpose of this research will be to identify consensus definitions of what Security as a Service means, to categorize the different types of Security as a Service and to provide guidance to organizations on reasonable implementation practices. Other research purposes will be identified by the working group.
The Security as a Service Implementation Guidance is made possible by the following sponsors:
Security as a Service Working Group Leadership
Security as a Service Co-chairs
Cameron Smith
Kevin Fielder
Kevin Fielder has over 15 years IT and security experience across multiple industries encompassing online trading, online supermarkets, banking/finance/insurance. His various roles have included pen testing and security assessments through technical and security architecture to security consulting and innovations.
Current focus includes security strategy, secure design and development, security innovations, software based mobile security, cloud policy and architecture, structured risk assessments, and of course his role as co-chair of the SecaaS working group.
He holds a Bachelors degree in Computing with Human Biology and a Masters in Distributed Systems and Networks, along with various industry certifications such as CISSP-ISSAP, CISSP-ISSMP, C|EH, ISEB enterprise and solutions architecture.
Security as a Service Working Group Initiatives
Open Peer Reviews
|Initiative Details
|Date Opened
Email Security
|August 24, 2017
|Contribute now
Intrusion Management
|August 24, 2017
|Contribute now
There are no working drafts at this time.
Thanks for your interest!
Your request to join Security as a Service has been recorded. Someone will be in touch with you soon with more instructions.
Connect with Us
Security as a Service Working Group News
February 12, 2013
CSA Announces Working Group Sessions at RSA in San Francisco
CSA is hosting sessions during the week for some of our active working groups. These are free events that will be held outside of the regular conference on Thursday, February 28th.
October 29, 2012
CSA Releases Security Information and Event Management (SIEM) Guidance
New Security-as-a-Service Implementation Report provides guidance for deployment of cloud-based SIEM
October 09, 2012
Cloud Security Alliance Releases (SecaaS) Implementation Guidance
CSA today announced that its Security as a Service (SecaaS) Working Group has completed its peer review process and has published implementation guidance documents expanding upon their "Defined Categories of Service" document that was first made available in August of 2011.
September 26, 2012
CSA Security as a Service (SecaaS) Working Group Completes Implementation Guidance
New Identity and Access Management research provides business and technical considerations for implementation of SecaaS as part of the cloud.
July 18, 2012
CSA Research Sponsorship Opportunities Available
CSA announces the availability of several new opportunities to sponsor key research initiatives. Your support helps us maintain our aggressive research schedule and accelerate responsible adoption of cloud computing.
August 18, 2011
Open Review Period for the Draft of SecaaS Defined Categories of Service Whitepaper Starts Today
The Security as a Service (SecaaS) working group would like to invite you to review and comment on the Security as a Service "Defined Categories of Service" whitepaper. Your expertise will ensure that the white paper has accurate content.
June 30, 2011
Security as a Service Initial Group Call set for July 5th
The CSA Security as a Service (SecaaS) Working Group will have their first group call on July 5th. The purpose of their research will be to identify consensus definitions of what Security as a Service means, to categorize the different types of Security as a Service and to provide guidance to organizations on reasonable implementation practices.
June 21, 2011
SecaaS Seeks Additional Input on Working Group Proposal
Thank you to those who have contributed to the "Categories of Service" section of our working group proposal. We are still seeking input to all categories. For those who have recently expressed interest in getting involved, send me an email at [email protected] (Subject line: SecaaS Categories).
June 07, 2011
SecaaS Seeks Input on Working Group Proposal
The Cloud Security Alliance is now soliciting input for the Security as a Service (SecaaS) Working Group's "Categories of Service" section of their working group proposal.
Security as a Service Working Group Downloads
Defining Categories of Security as a Service: Continuous Monitoring
In order to improve the understanding of Security as a Service and accelerate market acceptance, clear categorization and definitions of these services is necessary. This document provides a high overview of the business and technical elements needed to evaluate the risks associated with the category of Continuous Monitoring.
Release Date: February 29, 2016
SecaaS Category 7 // Security Information and Event Management Implementation Guidance
This document provides guidance on how to evaluate, architect, and deploy cloud-based SIEM services to both enterprise and cloud-based networks, infrastructure and applications.
Release Date: October 29, 2012
SecaaS Category 9 // BCDR Implementation Guidance
When using the cloud for operational processes and/or production systems, an organization's BC/DR requirements must be included in their procurement, planning, design, management, and monitoring of their cloud environments and cloud service providers.
Release Date: October 08, 2012
SecaaS Category 8 // Encryption Implementation Guidance
Encryption is a primary data (and application) protection technique. For encryption to be useful, encryption keys must be properly managed and protected. This document covers both the encryption and key management topics.
Release Date: October 08, 2012
SecaaS Category 6 // Intrusion Management Implementation Guidance
Because of the limited market maturity and lack of widely accepted best practices, this document provides implementation guidelines for cloud-based intrusion management service of multiple flavors—in the cloud, through the cloud, or from the cloud—focusing on the basic tenets of service and architecture rather than solutions.
Release Date: October 08, 2012
SecaaS Category 5 // Security Assessments Implementation Guidance
There are many choices for an assessment framework standard and there is no "one size fits all" solution for security assessments. One could reasonably expect that as cloud technology and governance evolves, a much smaller subset will emerge with a cloud focus.
Release Date: October 08, 2012
SecaaS Category 4 // Email Security Implementation Guidance
Due to its ubiquitous use, electronic mail is both the prime target of, and primary vehicle for, attacks, and must be protected on both ends: sending and receiving. Email service is a well defined utility in the enterprise, and securing email in the cloud is similar to securing email in the enterprise. Email Security as a Service (SecaaS) has a few unique aspects, but most responses entail differences of degree, rather than instituting new methods of security.
Release Date: October 08, 2012
SecaaS Category 3 // Web Security Implementation Guidance
The vendor and academic community have come together to form a set of solutions called Security as a Service. This document specifically addresses one element focused on Web Security as a Service (Web SecaaS).
Release Date: October 08, 2012
SecaaS Category 2 // Data Loss Prevention Implementation Guidance
DLP must be considered an essential element for achieving an effective information security strategy for protecting data as it moves to, resides in and departs from the cloud. DLP has two facets: one as viewed from the owner's perspective and one as viewed from the custodian's perspective.
Release Date: October 08, 2012
SecaaS Category 10 // Network Security Implementation Guidance
In a cloud environment, a major part of network security is likely to be provided by virtual security devices and services, alongside traditional physical network devices. Tight integration with the underlying cloud software layer to ensure full visibility of all traffic on the virtual network layer is important.
Release Date: October 08, 2012
SecaaS Category 1 // Identity and Access Management Implementation Guidance
This document addresses personnel involved in the identification and implementation of the IAM solution in the cloud. It will be of particular interest to those with the responsibility of designing, implementing and integrating the consumption of services of the IAM function within any cloud application of SecaaS.
Release Date: September 26, 2012
CSA V3 Guideline: Book Excerpts
Culture‐free, one‐size‐fits‐all English is usually the most efficient way to speak to a large, heterogeneous audience of E2s. In contrast, there are times when our English materials are intended for E2s in a small number of specific countries. In these cases, it might make good business sense to produce more than one English version, sensitive to the first language of the readers.
Release Date: July 02, 2011


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Build-a-Minimate, Minimates Museum, Free Posters, More...
Diamond Select Toys announcs that they will be attending the Chicago Comic and Entertainment Expo (C2E2), which takes place from April 26 to 28.
At booth #603, DST will have all (well, most) of their upcoming products on display, so you can check them out in person before they reach the stores. They'll also be giving away free posters, and selling selected items in the company store. Spend $18 and you can build your own Minimate at the Build-a-Minimate station. (Station open after 1:00 each day.)
Not too far away, at booth #1509, you can check out the Minimates Museum, an exhibit of Minimates past and present celebrating the 10th anniversary of the Marvel Minimates line. The exhibit will be open during show hours, so stop by, pick up a program and take a trip through mini-history, from Lord of the Rings to The Expendables, and everything in between.
And on Saturday, at 12:15 pm, in Room W470a, DST Marketing Supervisor Zach Oat will talk Minimates with anyone who will listen. He'll unveil never-before-seen artwork, debut some never-before-seen product and answer some never-before-asked questions. Plus, he'll give away a prize at the end to one lucky attendee!
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, PlasmaInfusion.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


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The Legislature adjourned today after completing work on the fiscal 2013 state budget which includes a $23 million increase for the state's three public universities.
UNI received a general fund increase of $6,379,273 – an 8.5 percent increase. That includes a 3.2 percent increase received by all three Regent institutions as well as a $4 million base budget adjustment.
We greatly appreciate the Iowa General Assembly's decision to increase funding for UNI.
Other funding includes:
$4.7 million for STEM (an increase of $2,965,344)
$175,256 for the Recycling and Reuse Center (flat funding)
$125,307 for the Real Estate Education program (flat funding)
$574,716 for Economic Development at UNI for the Institute for Decision Making, Metal Casting, and MyEntrenet (flat funding)
$900,000 to replace UNI's previous funding from the Grow Iowa Values Fund.
Tech Transfer and Business Incubation
Entrepreneurship/Economic Gardening
Regional Development
Ag Based Lubricants
Market Research for Iowa companies
The budget has now been submitted to the Governor, who has 30 days to sign or veto the bill. So while the process continues, we are grateful to the Legislature for recognizing the important role UNI plays in educating Iowa students and the unique financial challenge that presents. In particular, our local delegation was extremely helpful and fought for higher funding all session. Please reach out to them to express your gratitude.
We look forward to moving ahead with fiscal 2013 budget planning. This funding, along with the cost saving measures the university previously announced, will allow UNI to support its core mission, advance its priorities in teacher preparation and undergraduate education, strategically support and grow academic programs and serve Iowa's students and families.
Some of the more significant policy changes include:
SF2284 The education reform package establishes new testing standards for teacher preparation programs, requires two additional weeks for student teaching, requires continuous improvement plans for courses with more than 100 students, and creates several task forces.
SF 2225 It requires community colleges, private colleges and Regent universities to adopt policies to protect children from child abuse on campus but does NOT make all Regent employees mandatory reporters.
SF 430 An open records bill that creates a new Public Information Board and provides an exemption for draft documents.
Benjamin J. Allen


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On a professional level, Indiana has proven to me to be a fickle state. After everyone abandoned the Pacers with the "thug" era, and now seeing Colts fans follow Peyton to Denver... I am honestly embarrassed by it.
Indiana is a college state, and outside of Notes Dame football, which a lot of Indiana doesn't connect with as much as Chicago does, our colleges are basketball colleges.


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Thanissaro Bhikkhu wrote:AN 7:63, in its simile of the frontier fortress, compares the various levels of jhana to food for the soldiers of right effort and for the gatekeeper of right mindfulness. Only if the mind can experience a pleasure and rapture not of the flesh — in other words, not connected with sensuality — will it have the nourishment it needs to keep itself protected.
From: Right Mindfulness: Memory & Ardency on the Buddhist Path by Thanissaro Bhikkhu


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Date Nut Icebox Cookies Recipe
4.5 2
A dear friend shared this recipe with me many years ago. They've become a much-requested treat at my house, so it's a good thing the recipe yields a big batch!
Recommended: 20 Recipes for Your Christmas Cookie Swap
VERIFIED BY Taste of Home Test Kitchen
- 1 cup butter, softened
- 1 cup shortening
- 2-1/2 cups sugar
- 2 large eggs
- 1-1/2 teaspoons vanilla extract
- 1 tablespoon light corn syrup
- 5 cups all-purpose flour
- 1 teaspoon salt
- 1 teaspoon baking soda
- 1 cup finely chopped walnuts
- 1 cup finely chopped dates
- In a large bowl, cream the butter, shortening and sugar until light and fluffy. Add eggs, one at a time, beating well after each addition. Beat in vanilla and corn syrup. Combine the flour, salt and baking soda; gradually add to the creamed mixture and mix well. Stir in walnuts and dates.
- Shape into four 6-in. rolls; wrap each in plastic wrap. Refrigerate overnight.
- Unwrap and cut into 1/4-in. slices. Place 2-1/2 in. apart on ungreased baking sheets. Bake at 375° for 10-12 minutes or until lightly browned. Cool for 2-3 minutes before removing to wire racks. Yield: about 8 dozen.
Originally published as Date Nut Icebox Cookies in Best of Country Cookies 1999, p92
Reviews forDate Nut Icebox Cookies
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Greenpeace Germany made claims in a report that it believes that the western bean cutworm is a "new plant pest" that was "caused by genetically engineered corn." Refuting the claim is an article from the Journal of Integrated Pest Management. Authors of the JIPM article say Greenpeace Germany's results showed a "surprisingly simplistic conclusion" about the spread of the WBC over the past decade.
In "Genetically Engineered Bt Corn and Range Expansion of the Western Bean Cutworm (Lepidoptera: Noctuidae) in the United States: A Response to Greenpeace Germany," corresponding author William Hutchison, professor and chair of the University of Minnesota Department of Entomology, and his co-authors maintain that the Greenpeace report fails to consider broader ecological and agronomic factors which explain why the WBC's range has expanded. These additional factors include insect biology, synchrony of insect and corn phenology, reduced insecticide use, increases in conservation tillage, soil type, glyphosate-resistant crops, insect genetics, insect pathogens, pre-existing insect population densities, and climate change.
In addition, Greenpeace's claim that WBC is a new pest is just wrong. According to the authors, "the WBC was documented throughout the western Great Plains from Mexico to Alberta where it was found in the mid 1950s."
The WBC was originally collected in Arizona in the 1880s.
The authors explain some of the reasons for the spread of WBC include:
- Increasing use of conservation tillage favors larvae survival in the soil
- Reduced or eliminated use of insecticide applications as a result of increased use of Bt hybrids.
- Climate change.


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Country music will have a new shrine.
The Birthplace of Country Music Museum is set to open on Aug. 2 in Bristol, Tenn.
The museum is dedicated to preserving the legacy of the 1927 Bristol Sessions, which were some of country music's earliest commercial recordings. Those sessions featured such future legends as the Carter Family and Jimmie Rodgers and have had an immense and lasting impact on American popular music.
No less of an authority than the great Johnny Cash once referred to the 1927 Bristol Sessions as the "Big Bang of Country."
And Cash wasn't the only one who felt that way. In 1998, Bristol was officially recognized as "The Birthplace of Country Music" by the U.S. Congress.
As part of the celebration, a group of talented country musicians are combining forces on the new recording "Orthophonic Joy: The 1927 Bristol Sessions Revisited." Due out in October, the set will feature 16 re-recordings of the original songs from the Bristol Sessions, performed by such stars as Vince Gill, Emmylou Harris, Marty Stuart, Steve Martin and the Steep Canyon Rangers and Ashley Monroe.
For more information about the Smithsonian Institution-affiliated Birthplace of Country Music Museum, visit www.birthplaceofcountrymusic.org.
The Cowboy Junkies first came to fame with 1987's "The Trinity Session," a strikingly lo-fi effort recorded through a single microphone at Toronto's Church of the Holy Trinity.
That hushed affair, which blended folk, blues and rock in a fashion that most had never heard before, sold more than a million copies in the U.S. alone and produced so many memorable tunes. It's long been considered a stone-cold classic.
And that's a major reason why fans are so excited about the Cowboy Junkies' upcoming trip the Bay Area.
The group will perform "The Trinity Session" in its entirety during each of its two local concerts — Thursday at the Great American Music Hall in San Francisco and Saturday at the Freight and Salvage Coffeehouse in Berkeley.
The Canadian family-centric band — featuring guitarist-songwriter Michael Timmins, vocalist Margo Timmins, drummer Peter Timmins and bassist Alan Anton — is always great in concert. Yet, these "Trinity Session" shows should be really special.
Fans evidently agree with that assessment. Both of these shows sold out very quickly.
Follow Jim Harrington at http://twitter.com/jimthecritic and www.facebook.com/jim.bayareanews.


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Despite citations, several swine owners are refusing to fork over the pork.
State Senator Tony Avella wants to overturn city guidelines prohibiting residents from owning domesticated pigs as pets after constituents squealed for support.
"I try to get the city to crack down on illegal construction, illegal contractors where workers have died, where neighboring property owners have been disenfranchised and they have to sue, and I can't get the city to do as much enforcement on those serious construction sites as they are doing with one family with a very small pet," said Avella.
"The city should be consistent with the level of enforcement it conducts across the board."
Lou and Danielle Forgione picked up their porky pal after Danielle's brother Peter was killed in a motorcycle accident in March 2012. Searching for a pet to lift the spirits of their six saddened children proved tricky when their six-year-old son Nicky displayed a severe allergy to pet dander. A pediatrician suggested they consider a pig. Ten months ago, the Forgione's adopted Petey, named after Danielle's late brother.
"[Petey] brings joy right back to us," said Lou. "The kids were suffering in school. My wife was suffering from depression and anxiety. It brought the cheer right back to the family. He's doing his job and he's fantastic. You can't ask for anything more."
Since adopting Petey, the Forgiones have received several citations from the Health Department, including one that asked they "dispose" of their beloved pet. The co-op board of their Whitestone complex recently threatened to evict the family. Rather than relinquish Petey, the Forgione's set their sights on more "pig friendly" pastures, selling their home and moving to Suffolk County.
"We really love him," said Joseph, the Forgione's 13-year-old son. "He's a part of our family. He's like a brother to me."
Avella believes the rule against owning a pig is a Department of Health and Mental Hygiene (DOHMH) regulation, rather than a law that will need to be amended.
Navy veteran Nadine Darsanlal takes her 50-pound pet pig Wilbur to visit patients at hospitals and nursing homes and students at elementary schools. Darsanlal, who while in the service contracted bacterial meningitis that paralyzed her stomach and left her requiring the use a feeding tube and a pain pump, said she was "shocked" to discover the city outlawed ownership of the animal that brought happiness to her life and the lives of others.
"[Pigs] are gentler, they're kinder, they're more intelligent and they're cleaner. They are just lovely animals to have," said Darsanlal. "Not only does he help me out but I kind of want to give back and help others out."
The College Point resident trained her precious piggy to complete small tasks, including retrieving items Darsanlal accidentally drops to keep her from having to painfully bend over. While Wilbur provides physical assistance, it's the emotional support he gives that makes him more than just a pet.
"He's a companion. He gets me up and going in the morning and helps me not think about my illness," said Darsanlal. "It's a lot that I'm dealing with, but I can deal with it because I've got my little baby."


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Mini Cooper Convertible
by Josh Rubin
on 06 August 2004
The Mini Cooper Convertible is about ready to ship, just in time for, um, Fall. Aside from the redesigned dash I flipping off Hummers in your neighborhood soon.
by Josh Rubin
Need to rent a car for a few hours? Want a quick way to reserve, pick up and drop off? Zipcar is the answer. Use their search tool to get a map of cars near you, book it, then pick it up from an on street parking space. All you need is your Zipcard...
Freestyle MINI Game
by Jacob Resneck
If you're looking for a little diversion with your Sprint mobile phone, you'll soon be able to download the Freestyle MINI handheld game. Unlike real life as well as Grand Theft Auto and Outrun!, players are rewarded by obeying speed limits...
Illustrated Mini Cooper
by Josh Spear
Remember the Mini Cooper Convertible we all can't wait to get our hands on? It has a choice of twelve exterior colors, three hood colors, eight potential dash colors, and nine interior trim options. That's darn customizable--but now you can...
Mini Concept Tokyo
by Josh Rubin
Mini Traveller concept shown at the Frankfurt Auto Show was created as a tribute to the original 1960 Traveller. It's a good looking consideration for how to evolve a Mini to be a better schlepper. Yesterday, at the Tokyo Auto Show, Mini presented...
Mini Convertible
by Josh Rubin
Mini has just announced the Cooper Convertible. There are lots of pictures over at Mini2 , as well as a copy of the press release . It's pretty cute, but something about the design just isn't doing it for me. Maybe it's the color of the model. When...
ICFF Preview: Bisazza Mini Cooper
by Josh Rubin
Bisazza, the mosaic tile masters, have been touring a series of tile covered Mini Coopers. Their next stop? ICFF next week here in NYC. Check out Mini2 for some more press shots.
MINI White Rabbit
by Josh Rubin
To celebrate the MINI Cooper and its British heritage UK agency Profero created a Follow the White Rabbit banner ad campaign. Starting on sites like Urban Junkies click-thrus on the MINI banner ad take you on a fascinating random tour of British culture...
MINI Motorby Billboard
by Tim Yu
MINI of BMW is using advanced technology to communicate directly with drivers through talking billboards called MINI Motorby. Instead of seeing billboards with the same mind-numbing casino ad, these boards feature a changing array of unique, personal...
MINI The Book
by Evan Orensten
MINI The Book is a look at history through the eyes of the Mini Cooper since its iconic birth in 1959. Since its creation the Mini has inspired generations with its practicality, sensibility and personality. The passion generated by its owners and...
Mini Cooper Clubman
by Josh Rubin
Similar in looks and configuration to the Mini Traveller concept car, an all-new addition to the Mini range, the Clubman hits international streets this November. New proportions and a style reminiscent of the past distinguish this "stretched...
Mary Lou Pavlovic
by Evan Orensten
Originally inspired by her reaction to the UK punk culture of the 1980s, Australian artist Mary Lou Pavlovic created a "Facist" series covering work boots in what looks like multicolored candy decor. She has since gone on to realize ballet...
Test Drive: 2014 Mini Cooper Hardtop
Hitting the coastal roads in Puerto Rico with the latest refined yet playful compact
by CH Contributor
by Davis Adams "These bright colors are so hard to manufacture, and we didn't want a trendy yellow," explains Annette Baumeister, leader of the color and trim engineering team at Mini's Munich office. She's particularly proud of the Volcanic Orange...
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A funny thing happened on the way from the dairy case to the produce section... U.S. Secretary of Agriculture Tom Vilsack made a stop in the Easter Egg aisle.
While visiting a Hy-Vee supermarket in Sioux Falls, S.D., on Thursday, Vilsack showed that we are all human and prone to indulge our sweet tooth every now and then ― even though there is also the responsibility to push for healthier eating.
Vilsack stopped and wondered aloud about getting jelly beans since it is Easter. A dietitian standing next to him agreed "a little bit is fine… moderation."
Vilsack eventually made it to the produce section where he announced that $285 million in incentives would be made available to states to encourage healthy eating. He also shared the results of a pilot study in schools where it was shown that young people will eat fruits and vegetables when given the choice.


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Iran Says Attack From Israel Would 'Harm America'
Martha Raddatz discusses the warning from Iran's supreme leader.
Is Iran More Willing to Attack U.S.?
Martha Raddatz discusses a new warning from U.S. intelligence.
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1927 Hollyhock Circle
Farmington, New Mexico, 87401
Commute to Downtown Farmington
Almost all errands require a car.
About your score
1927 Hollyhock Circle has a Walk Score of 22 out of 100. This location is a Car-Dependent neighborhood so almost all errands require a car.
This location is in Farmington. The closest park is Jaycee Park.
Explore how far you can travel by car, bus, bike and foot from 1927 Hollyhock Circle.
View all Farmington apartments on a map.
Popular apartment searches include furnished, fireplace and fitness.
This location is in the city of Farmington, NM. Farmington has an average Walk Score of 29 and has 45,877 residents.Learn More About Farmington


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Change Country:
Shop our huge range of digital SLR cameras with models to suit all levels of experience, from professional photographers looking to upgrade their current equipment, through to enthusiasts wanting to invest in a new model. We also stock a great range of DSLR cameras perfect for those newer to photography who want the best equipment around. With the latest SLR models from big camera brands such as Nikon, Canon and Pentax, you will be sure to find the best digital SLR camera for you. Or, if you're looking to get the most out of your new DSLR model, why not shop our accessories collection for essential shooting equipment items.
With cashback availability options and trade in bonuses available with many of our digital SLR cameras, why not buy online with Calumet Photographic today and get a variety of delivery options, such as Free Next Day Delivery as well as a 30 Day Returns window.
We know that choosing your next digital SLR camera is a big decision based only on what suites you best, so feel free to come into any of our store locations to test our range of DSLRs, and our teams of photography experts will be more than happy to answer any questions you may have.


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Moderators: Timko, Fritz, Solty, Booter, Blake_T, Frank Delicious
JHern wrote:If your putter isn't your favorite disc, get a new putter.
LADG Jones wrote:Would like to see pics of the Opto River, GL River, 11x Teebird and possibly the Ace Race Hornets since you have four of them. It's not a waste of your time, I have stuff on your want list I'm willing to part with, Brand new Z Pred, Brand new GL Flow, both bright ass colors... firstname.lastname@example.com
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New Faces on AU's Basketball Court for the 2013-14 Season
Bender Arena boasts many new faces this year. The 2013-14 basketball season is a unique one for AU in that the university is welcoming not only a new director of athletics and recreation, Dr. Billy Walker, but also new head coaches in both basketball programs. Both new coaches bring previous experience with AU's programs and an impressive record of success for the Eagles to build upon.
Mike Brennan was named head coach of the men's basketball team in April. He most recently served as an assistant coach at Georgetown University, but also served two seasons as an assistant coach at AU during which the Eagles experienced their two greatest years in program history, winning back-to-back Patriot League Regular Season and Tournament Championships, advancing to the school's first-ever NCAA Tournament berth. Mike's impressive pedigree also includes playing and coaching for his alma mater, Princeton University, as well as serving for one year as a volunteer assistant coach at Columbia University.
"I couldn't be more excited about naming Mike Brennan as the next head coach at American University! Mike embodies all the qualities we were looking for in a coach: integrity, character, experience recruiting at a high-end academic institution, ability to connect with players, toughness, and unmatched skills in player development and teaching," said Walker. "Above all, Mike is the ideal role model and mentor for our young men to emulate. Mike understands the primacy of academics, but knows we can compete for championships as well—he's the perfect fit!"
Megan Gebbia was named head coach of the women's team in August. Megan most recently served as associate head coach at Marist College, but also served as an assistant at AU for the 1995-96 season, in addition to stints as an assistant at Wright State and the University of Maryland-Baltimore County. Megan began her coaching career at her alma mater, Towson University, and served as team captain of the Tigers' squad during her senior season.
"Coach Gebbia's record both on and off the court is nothing short of breathtaking," said Walker. "In 10 years at Marist College, she helped lead her team to 10 consecutive 20-win seasons, including the program's first two 30-win seasons. She has been to the NCAA tournament nine times, winning five tournament games in the last seven years—including a trip to the Sweet Sixteen. Her overall record while at Marist is 264-64… an unbelievable 200 games over .500. I couldn't be happier to welcome Megan to the American Eagles family!"
The men's basketball team (1-1) is on a four game road trip, which tips off at No. 8/8 Ohio State tonight. View the men's basketball schedule.
Women's basketball (2-0) hosts Dartmouth in its next home game on December 1. View the women's basketball schedule.


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Just Scrap Radio Episode 10: Joe Duarte, Benson Henderson, KJ Noons (Full Archive) | UFC NEWS
BJPENN.COM'S "Just Scrap Radio" returned yesterday with hosts Jens and Abel Pulver. On this week's panel of guests we had Strikeforce fighters Joe Duarte and KJ Noons. UFC lightweight champion Benson Henderson also made a surprise appearance. Check out the full archive below.


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I just fear that there's going to be one game where the defense will not deliver and the offense has to win the game.
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I just fear that there's going to be one game where the defense will not deliver and the offense has to win the game.
He has a concussion. He still hasn't been cleared to practice. He was playing well at the end of the game.
It's not working perfectly. ND is still struggling mightly to score the ball, outside of the Navy/U games. Their defense has just been on another planet. Without their stellar play, and if it was just average ND defense, there would be trouble in South Bend offensively.
Winning covers up a lot of things.
How ****ing stupid are the Oklahoma fans? They're loud as hell while their team is on offense. Dumb.
If the center could hear the QB, maybe he doesn't snap it early.
It wasnt pretty, but well take the "W"
Good to know I was not the only one thinking that
I actually saw a tweet twitter that said "today's game features the highest graduate percentage versus the lowest" or something to that effect, and ended with "you figure out which team is which". Was just funny cause I saw that right after the crowd went nuts when they were in the red zone.
Maybe they need a "SHHHH QUIET OFFENSE AT WORK" sign on the jumbo-tron like the Redskins have at Fedex
They'll never be as trained as Colts fans have been during the Manning era.... when the offense takes the field.
If you were still doubting Notre Dame is back.
IU bball number 1 in the country...Notre Dame football solidly in the top 5. We are either at the end of the world as we know it, or somewhere in the mid 80s.
The world is a better place when Notre Dame is good. I am sorry that I cannot say the same thing about IU basketball.... I still hate them... Go, Kentucky..... at least when they play IU....
I thought it looked beautiful. Our defense was suffocating in a hostile environment. Our rushing attack was damaging and controlling the clock. Golson was accurate and we did not turn over the ball. I don't see how it was in any bit ugly. The BYU games was ugly. The Purdue game was ugly. But we put 31 points AT Oklahoma. This is an improvement.
#3 in the BCS behind Bama and Kansas State. LET'S GO OKIE STATE!!!!
9-0 first time since 1993 I thought we were going to lose that game
I wasn't sure we were going to come back and win, but I was confident, almost certain, they were going to mount a comeback.
I hope these young men got a wake up call and realized teams are not going to roll over just because they are playing ND. They need to show up every week.
And please lord, leave Reese on the bench. Good grief he had a terrible throw (granted Everett also missed some really bad reads in the first quarter)
A win is a win, and 9 and 0 is 9 and 0
Go Irish!
I'm always an optimist. But, I'd be lying if I told you that I thought we'd be sitting at #4 in week 11. Irish, Pacers and Colts all had close-calls this weekend. It's been a fun year so far.
I don't see a thread for this, but it tangentially concerns the Irish, so I'll throw it in here: Alabama is looking very vulnerable against Texas A&M today. Johnny Manziel is amazing to watch. The Aggies have a talent for blowing big leads, so I think game is very, very far from over, but their offense is really good. If Bama loses this game...the Irish are sitting pretty for a possible BCS National Title game.
Have to hope ND wins out and either Kansas St or Oregon loses in the next two weeks
Or how about both?!?!?
Sigh. ND #1 in football, IU #1 in basketball. Shoot me now.
Ugh...only thing I hate about it is now the SEC is almost assuredly in the title game again with either Alabama or Georgia (actually hoping for Georgia for a little change). If Notre Dame loses to USC (seems less likely if Barkley is injured) then all hell breaks loose, I'm guessing Oregon goes back to #2 if they win out.
"It's just unfortunate that we've been penalized so much this year and nothing has happened to the Pistons, the Palace or the city of Detroit," he said. "It's almost like it's always our fault. The league knows it. They should be ashamed of themselves to let the security be as lax as it is around here."
----------------- Reggie Miller
The last time that both happened was in 1993
Weird huh?
Although I am an ND fan and don't like IU(although I am a student in their business school go figure)
The funny thing is that it took the alums of RGIII and Luck to help Notre Dame accomplish this.
What are the odds?
This is ****ing awesome.


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Images shown may not be an exact representation of the actual product.You may contact us if you have questions about the exact specifications of this item.
Stoeger adds to its Condor line of O/Us with the Longfowler, a 30-inch barreled, 3-inch 12 gauge. Weighing about 7 ½ pounds with a matte finished walnut stock, the Longfowler should make a good choice for a hunter who wants an inexpensive break action gun to abuse in the blind, and it will double as a target gun, too. The Longfowler has a vent rib and vented side ribs and extended choke tubes.
Stock: A- Grade
Caliber: 12 Gauge
Chokes: Screw-In (IC & M)
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And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
This t-shirt pays homage to Williamsburg, Brooklyn's Metropolitan Bath & Pool. It was build in 1922 to be used by local residents who were without indoor plumbing. Now it's a local pool. And a sweet t-shirt.
- Printed t-shirt
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text: Ethics Commission in contract talks with director finalist By Phil Kabler February 7, 2013 Story Share CHARLESTON, W.Va. -- Members of the West Virginia Ethics Commission did not hire a new executive director Thursday, but authorized current executive director Theresa Kirk and personnel committee chairman Jon Turak to enter into contract negotiations with the finalist.Commission members took that action after meeting in executive session to get an update from the personnel committee, which over the past month has interviewed seven applicants for the position.Kirk, who has been executive director for the past four years, and was legal counsel for the commission for the previous four years, announced in December she would be stepping down to seek employment in the private sector.Kirk's last day will be March 8, and she said Thursday that plans are to have the new executive director on board before then, to allow for a transition period. By law, the executive director of the Ethics Commission must be a lawyer.Also during Thursday's meeting, commissioners:• Determined that a high school principal may be employed at a business owned by a coach at the high school, but should not participate in annual performance evaluations for the coach."It's an unusual, unique situation," said Kirk.Although requests for ethics advisory opinions are confidential, the request evidently comes from Greenbrier East High School Principal Jeff Bryant, who also is director of entertainment at The Greenbrier resort.Jim Justice, owner of The Greenbrier, coaches the boys and girls basketball teams at Greenbrier East. • Postponed action on a request for an advisory opinion on whether municipal employees in a small town may use city equipment for personal use.Commissioners were told it is a common practice in small municipalities in the state to allow employees to be able to use city owned equipment, such as backhoes, for personal use at no charge or at discount.After extended discussion over whether the practice amounts to an acceptable fringe benefit for low-paid town employees, or a potential ethics law violation, commissioners tabled the matter to the March meeting."To me, the issue is, are they allowed to offer this as a fringe benefit to employees?" Turak said.• Granted an employment exemption to Eric Coberly, chief of the Office of Abandoned Mine Lands and Reclamation in the Department of Environmental Protection, in order to seek employment with regulated private-sector businesses.• Agreed to submit a formal request to Attorney General Patrick Morrisey to authorize Deputy Attorney General Marty Wright to represent the commission on various matters. Wright, who had been a legal counsel for the commission before joining the Attorney General's Office last month, has several matters pending. Among them is a hearing for Beckley Mayor Emmett Pugh, who faces ethics charges for allegedly exchanging city contracts for financial interests in those companies."We feel it is in the best interest of the commission to have Marty take that matter to public hearing," said Kirk, who said Morrisey has agreed to allow Wright to represent the commission.Reach Phil Kabler at email@example.com or 304-348-1220. Story Share Story Share Trending Now 1 Facebook founder visits Cabin Creek Health Systems 2 SBA board OKs canceling Logan's construction management contract 3 Parole board seeks report on Lavigne for possible release from prison 4 Chuck McGill: Barry Switzer takes a special interest in former George Washington star 5 Congressional opioid investigation targets drug wholesaler Miami-Luken Stewart agrees to plea in husband's slaying Previous Story Bulletin Board: Feb. 8, 2013 Next Story


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Supplier News — PepsiCo and GNC are teaming up to develop and sell fortified coconut water products. The Phenom brand will launch during second quarter 2011 and will be sold exclusively at GNC stores and GNC.com.
One of Hershey's popular mint brands is adding a powerfully cool taste experience to its line. Ice Breakers Frost sugar-free mints are coated with xylitol, cooling and flavor crystals and will be available in Wintercool and peppermint varieties. The mints are now available in 1.2-oz. containers.
La Famiglia DelGrosso pasta sauces were named one of the "125 Best Food for Men" by Men's Health and also received a "125 Best Packaged Food" award from Women's Health. One serving of Chef John's tomato basil masterpiece, the Men's Health winner, is only 70 calories and contains 1 g of protein, 8 g of carbs, 2 g of fiber and 4 g of fat. Meanwhile, the Women's Health winner, Uncle Joe's vodka celebration sauce, has 90 calories, 6 g of fat (2 g of saturated fat), 8 g of carbs, 430 mg of sodium, 2 g of fiber and 2 g of protein.
Tostitos has launched its new Tostitos Artisan Recipes tortilla chips. The chips are available in two flavors — roasted garlic and black bean, and fire-roasted chipotle — and are made with 100% natural ingredients that are added right into the chips, according to the company. The chips are available in 9.75-oz. bags at a suggested retail price of $3.99.
Executive News — A former Wyeth executive has been named PepsiCo's EVP global corporate affairs. Tim Cost officially joined the company Dec. 1. In the newly created position, Cost will be responsible for strengthening and protecting PepsiCo's corporate reputation and strategically aligning its communications, public policy, foundation, investor relations, global health and agricultural policy, and regulatory agendas.


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Dr. Tanya Richardson
Associate Professor (Currently On Leave)
Contact InformationEmail: firstname.lastname@example.com
Phone: 519-884-0710 ext.3865
Fax: 519-884-8854
Office Location: DAWB 5-120B (beside DAWB 5-120)
Office Hours: Email professor/by appointment only
Academic Background
BA (1995) University of British Columbia
MPhil (2000) and PhD (2005) University of Cambridge
My current research addresses the politics of nature and environmentalism in the Odessa region of Southern Ukraine. Since 2009, I have been carrying out SSHRC-funded research in the Danube Delta town of Vilkovo on residents and nonresidents changing relationships with silt, water, fish, reeds, and birds in the context of the creation of a transboundary biosphere reserve and a rapidly transforming political economy. A second project examines the changing strategies of environmental activists in the Tatarbunary District in their struggles to dismantle a failed Soviet-era Irrigation project and restore Lake Sasyk as a saltwater estuary. I am also working with Gisa Weszkalnys to develop an anthropological approach to the study of natural resources that links an ethnographic approach with insights from posthumanist theory on the distributed nature of materiality. www.engagingresources.org. Previously I conducted research on urban place-making practices, memory, and cosmopolitanism in the Black Sea port of Odessa.
Forthcoming. The Politics of Multiplication in a Failed Soviet Irrigation Project, Or, How Sasyk Has Been Kept from the Sea, Ethnos.
2015 Conflict and Conservation in Ukraine's Danube Delta: On the Limits of Liberalism in Participatory Environmental Governance, Development and Change 46(3).
2015. (In)Accessible Land: The Changing Practices and Regulation of Gardening in the Reedbeds of Ukraines Danube Delta, in The Biopolitics of the Danube Delta: Nature, History, Policies. Eds. Kristof van Assche and Constantin Iordachi. Lexington Books.
2014 Odessa's Two Big Differences (and few small ones). Life after the Maidan and May 2. September 1. http://www.eurozine.com/articles/2014-09-01-richardson-en.html
2014. (with Gisa Weszkalnys) Resource Materialities: New Anthropological Perspectives on Natural Resource Environments, Anthropological Quarterly 87(1):5-30.
2008. Kaleidoscopic Odessa: History and Place in Contemporary Ukraine. University of Toronto Press: Toronto.
2006. Living Cosmopolitanism? Tolerance, Religion and Local Identity in Odessa, in The Postsocialist Religious Question: Faith and Power in Central Asia and East-Central Europe. pp. 213-240. ed. Chris Hann. Lit: Berlin.
2005. The Place(s) of Moldovanka in the Making of Odessa, The Anthropology of East Europe Review. Fall: 72-89.
2005. Walking Streets, Talking History: The Making of Odessa, Ethnology 44 (1): 13-33.
2004. Disciplining the Past in Post-Soviet Ukraine: Memory and History in Schools and Families, Politics, Religion and Memory: The Past Meets the Present in Contemporary Europe. pp.109-135. eds. Frances Pine, Deema Kaneff and Haldis Haukanes. Lit: Munster.
2002. Along the Roads of Family Histories. (in Russian and Ukrainian) With contributions from Ilia Dyshlevoi, Denis Kovalev, Olesia Kushchevaia, Daria Olifer, Julia Serbina and Dmitrii Shubakov. Astroprint: Odessa.


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Today's Sunday sounds will just focus on one song: When I Hear Music by Debbie Debb. This song gets my vote for "Best Freestyle Song Ever". Freestyle was an 80s genre of music mostly based out of New York and Miami.
"Freestyle reached its peak in 1987 before it fell in popularity and was slowly replaced by burgeoning house music in 1988. Silent Morning, composed by Noel (poster boy for Freestyle), hugely boosted Freestyle's popularity and brought it to the forefront of the international scene in 1987, expanding its potential. But, before Freestyle could make a permanent impact, by the late 80s and early 90s, house music, a reincarnation of 1970's disco, challenged the original, upbeat 1980's Freestyle." – Wikipedia.org
Besides the fact that I just think this song is hot I hear some nice equipment: Roland TR-808, Simmons Toms, Minimoog Bass, Analog White Noise Thunder Noises, and a great Vocoder. Can you pick out anything else? I know everything could have been done with sampling but I'm going to guess most of the stuff used was the real deal to tape.
So get your girlfriend to spray a "Mall Claw" on the front of her hair and head to Dancin in Palisades Park for teen night. Next, repeat after me: ewwwua ewwwua!
Buy this song: Amazon


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Some of the Europe's - and the world's - biggest industry players have now become caught up in the horse meat story, with product recalls at a high and consumer confidence at a low.
Indeed, the latest UK sales data shows plummeting consumer confidence has led to a 43% drop in sales of frozen burgers, while sales of frozen ready meals are down by 13%.
Take a look below to see the who, where, what, why and when of the scandal so far, courtesty of the Australian Institute of Food Safety.


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The Commissioner, Deputy Commissioner, and their staff provide overall policy and management direction to the department. The commissioner's office oversees the divisions, boards and councils that make up the agency. The commissioner's office works with the legislature to insure that the governor's and the department's goals and initiatives are met and to insure that adequate resources are available for the department to carry out its missions.
For more information on the divisions, boards and commissions that make up the department please refer to the main DPS web page.
Office of the Commissioner Feedback


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Surely O'Brien won't let this go unpunished. Who will steal all the rebounds and jack up 3's with no arc???Mavericks Waive Troy Murphy To Sign Derek Fisher
Nov 29, 2012 3:42 PM EST
The Dallas Mavericks have waived Troy Murphy to sign Derek Fisher.
Murphy was signed shortly before the start of the season.
Murphy averaged 4.6 points and 3.5 rebounds in 18.3 minutes over 14 games.


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Caldecott Honor Book
ALA Notable Children's Book
About the Book
Truck is written and illustrated by the celebrated creator of Freight Train, Bigmama's, School Bus, and many other classic and award-winning picture books for young children. Truck was named a Caldecott Honor Book by the American Library Association and was also named an ALA Notable Book for Children. It is an ideal book to share with preschoolers, both at home and in the classroom—especially those who love books about transportation!
In this wordless picture book, a large, bright red trailer truck packed with tricycles moves through pages of fog, truck stops, and crowded highways. "Beautifully executed and appealing."—School Library Journal
Supports the Common Core State Standards
Educator and Librarian Resources
Product Details
- Imprint: Greenwillow Books
- On Sale: 04/01/1980
- Trimsize: 9.813 in (w) x 8 in (h) x 0.25 in (d)
- Pages: 32
- List Price: 17.89 USD
- Ages: 0 to 5
- BISAC1: JUVENILE NONFICTION / Concepts / General
- BISAC2: JUVENILE NONFICTION / Concepts / Colors
- BISAC3: JUVENILE NONFICTION / Transportation / Cars & Trucks
- Lexile® Measure: NP


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Study to Compare the Virologic Efficacy in Cerebrospinal Fluid (CSF) and Neurocognitive State in Patients Infected by HIV-1 Long-term Treatment (> 3 Years) With Lopinavir / Ritonavir Monotherapy
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|Procedure: Lumbar puncture
|Phase 4
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Exploratory, Cross-sectional Study to Compare the Virologic Efficacy in Cerebrospinal Fluid (CSF) and Neurocognitive State in Patients Infected by HIV-1 Long-term Treatment (> 3 Years) With Lopinavir / Ritonavir Monotherapy
- Ultrasensitive HIV-1 RNA in CSF [ Time Frame: week 0 ]
- CD4 cell count [ Time Frame: week 0 ]
- Plasmatic HIV-1 Viral load [ Time Frame: week 0 ]
- Plasmatic and CSF trough-LPV concentration [ Time Frame: weeks 0 ]
- Neurocognitive alteration, present when there is a diagnosis of any neurocognitive disorders associated with HIV (HAND). [ Time Frame: week 0 ]
- Overall deficit ratio (GDS) [ Time Frame: week 0 ]Calculating a value of overall neurocognitive functioning, based on an evaluation of 7 representative areas in HIV infection (attention / working memory, speed of information processing, verbal memory, learning, verbal fluency.
- Adverse events [ Time Frame: week 0 ]
|Study Start Date:
|August 2010
|Study Completion Date:
|June 2011
|Primary Completion Date:
|June 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: LPV/r monotherapy 400/100 mg twice daily, orally administered
LPV/r monotherapy 400/100 mg twice daily, orally administered
Procedure: Lumbar puncture
Lumbar puncture at week 0
Other Name: NP
Active Comparator: Lumbar puncture
LPV/r 400/100 mg twice daily + 2 NRTI, orally administered.
Procedure: Lumbar puncture
Lumbar puncture at week 0
Other Name: NP
Detailed Description:
Combinations of antiretroviral for the management of HIV infection recommended by the main treatment guidelines include a combination of two nucleoside analogue reverse transcriptase (NRTI) with a non-nucleoside reverse transcriptase (NNRTI) or an inhibitor protease (IP) .1 However, NRTIs can inhibit mitochondrial DNA gamma polymerase, causing mitochondrial dysfunction, which in turn can result in related adverse effects such as peripheral neuropathy, pancreatitis, hepatitis, abnormal lipid profile or lipodystrophy. Therefore, it is advisable to design and search for therapeutic strategies to avoid prolonged exposure to NRTIs and their adverse events.
IP monotherapy as a strategy of simplification, after an induction period with standard triple therapy may be useful to minimize the risk of mitochondrial toxicity by NRTIs. Additionally, this strategy may be useful to improve treatment adherence, reduce costs and preserve future treatment options. In this sense, monotherapy with lopinavir / ritonavir (LPV / r) can be an effective option for the treatment of HIV-1 as a simplification strategy in routine clinical practice.3 OK04 study showed that in patients with sustained viral suppression simplified to monotherapy with LPV / r, rates of viral load <50 copies / mL were similar to that patients continuing on standard triple therapy.4, 5 However, the virological efficacy of this strategy in the CSF compartments has been questioned by some authors. Like most protease inhibitors, lopinavir has a poor penetration in CSF. Thus, despite the concentration of lopinavir in CSF usually exceed the inhibitory concentration (IC50) of wild strains of HIV, it is possible that some patients may present lopinavir concentrations insufficient to achieve sustained suppression of viral replication in that compartment. In this sense, according to results from a recent study, up to 10% of patients treated with lopinavir / ritonavir monotherapy may present detectable levels of viral load in CSF while maintaining a CV <50 copies / mL in plasma.9
On the other hand, about half of patients on antiretroviral therapy (HAART), despite achieving virologic control and the treatment is performed properly, have been neurocognitive dysfunction.10 This has been associated with multiple risk factors, including the presence of HIV in CSF.11 In fact, even though achieving undetectable viral load in plasma, up to 40% of patients on HAART show presence of virus in CSF.12 This also has been associated with a worse neurocognitive functioning. Therefore, the maximum control of viral replication is shown as a priority for the improvement of CNS dysfunction.
Based on the above, the objective of this study is to explore and evaluate the virological efficacy and safety at long-term neurocognitive level (> 3 years) of monotherapy with lopinavir / ritonavir as a strategy to simplify antiretroviral therapy in patients infected by HIV.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Experimental group:
- Patients having a diagnosis of HIV infection, on stable treatment at least 3 years with LPV/r monotherapy, the inclusion of patients with at least 2 years will be permitted if it is not possible to include the expected number of patients.
- Initiating monotherapy with lopinavir / ritonavir maintaining values of plasma HIV-1 RNA undetectable (cv <50 copies / mL).
- Maintain complete virologic suppression (CV <50 copies / ml) in plasma for at least 3 years in treatment with LPV / r monotherapy. (Or 2 years, if not complied with the expected number of patients with at least 3 years with LPV / r monotherapy).
- Good adherence to treatment (> 90%).
- Signing of informed consent.
Control group:
- Patients having a diagnosis of HIV infection, on stable treatment at least 3 years with LPV/r 400/100 mg twice a day + 2 ITIAN, the inclusion of patients with at least 2 years will be permitted if it is not possible to include the expected number of patients.
- Maintain complete virologic suppression (CV <50 copies / ml) in plasma for at least 3 years in treatment with LPV / r monotherapy. (Or 2 years, if not complied with the expected number of patients with at least 3 years with LPV / r 400/100 mg 2 twice a day + 2 ITIAN).
- Patients that can be put into pairs with the experimental ones following these characteristics: age, sex, presence of previous virologic failures, nadir CD4 + T lymphocytes and viral load <50 copies / mL time prior to inclusion in the study. Patients having a diagnosis of HIV.
- Good adherence to treatment (> 90%).
- Signing of informed consent.
Exclusion Criteria:
- Vaccine administration, acute or chronic uncontrolled infection in the 2 months prior to the inclusion or medical assessment which in the opinion of the investigator, might compromise the results of the study.
- Pregnancy or breastfeeding.
- Therapies that include interferon, interleukin-2, cytotoxic chemotherapy or immunosuppressant at baseline.
- Do not sign the informed consent.
- Existence of any contraindication to the performance of lumbar puncture.
- Presence of psychiatric disorders or being in psychopharmacological treatment.
- Active alcohol consumption (> 50 g / day) or illicit drugs.
- Existence current or past opportunistic infection involving CNS functioning alteration.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01116817
|Germans Trias i Pujol Hospital
|Badalona, Barcelona, Spain, 08916
|Responsible Party:
|Lluita Sida Foundation
|ClinicalTrials.gov Identifier:
|NCT01116817 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 30, 2010
|Last Updated:
|July 13, 2011
Keywords provided by Germans Trias i Pujol Hospital:
Long-term Lopinavir/ritonavir monotherapy
neurocognitive performance
ultrasensitive CSF-viraemia
Additional relevant MeSH terms:
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 25, 2017