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United Piano Movers San Diego
There are surprising places to take back your professional vocation in the most odd places in the world. Some, want to
simply make it big so they go big fighting the top competitors and stumble, fall, – but do they get back up?
See the problem is most people like to simply run before they can even crawl. And when you're new to the business world, there are many challenges that one will face, it's simply fact. When you want to take back your professional vocation you have to do it with a sense of poise and rationality.. excuse the Panic at the Disco line, however, this is very true. And whether you're starting a piano moving business or a new limo company, ask yourself, "do I have the strength to finish what I've started?"
One needs to turn over different aspects of the business venture they wish to endeavor if they ever want to see some sort of long lasting success. It's just simply how it goes. There will be unforeseen factors and the more you prepare yourself to deal with these cunning aspects of life, the better you will be off, once adversity arises. Because if you fall, if and when you fail, do you want to lay on the ground? Many will be quick to answer, -no.. no way, not me! But the truth is, when you are slammed right in the middle of a difficult position, you're mind set and attitude will take over, unless you have control of your mind.
Basically what I'm getting at is that you will endure hardship when starting your own business and your success will be revealed by how you over come each obstacle that encounters you. Because each obstacle will affect you emotionally, physically, and will be very demanding. It is how you choose to perceive the situation that will attribute to your long lasting success.
Which leads me right into my next point, choosing a business that's right for you. There are factors you will want to look at that will make the endeavor that much more in your success, or your failure.
- Is the area of profession you have chosen something you are passionate about? This will make all the difference in your long lasting success.
- How do you handle challenges? You may want to evaluate your psychological development to see if you can make any improvements in your mind power.
- What will you do when the s hits the fan?
This may seem like pretty basic stuff, but as you will see, a case study of business shows it to be pertinent information. Like when Jacob and his father opened United Piano Movers San Diego. He was just in his early 20's when he started the piano moving business in San Diego, however, with much fight in him, he was able to successful plant himself as a mover and shaker in the industry with their company lasting for over 10 years and still going strong.
He actually began in school, when he was taking music classes, noticing how difficult and amazing it was to hoist a piano by crane out of the music hall. And being a business student, he was inspired.. Later spoke to his father and decided he was going to go for it. But you know what? It was tough, really tough. I mean, he was sure to fail right? Yes, he did. He failed during his Piano Moving Service many times but you know what? It only made him that much wiser and that much more capable of handling the next set of adversity, because he never quit. And he had this ignitable passion for San Diego piano movers.
So now, 11 years later, Jacob and his father still run United Piano Movers San Diego with extreme success. It didn't happen overnight but they have gained the experience and the credibility that is needed for a long lasting business. And it wasn't always about the money, many times, it was simply about providing happy customers with a "happy service" meaning, a piano moving service that actually benefited everyone (pianos being damaged as minimally as possible).
This is one of those extreme cases of success, but is really amazing to look at from a case study standpoint because this tale has all the makings of a proper business. There is passion, care, longevity, and credibility. All the things that have made up this piano moving business through the years. Hopefully this may give you insight into how you can regain your professional vocation. Maybe you like animals? You could start a mobile grooming service, perhaps? I don't see why not. Just do you due diligence and ensure your success before ever stepping foot on the court.
May your business be ever as successful and profitable as United Piano Movers San Diego.


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When I read dhammawheel, I don't want to go in all categories to check the messages, so I use the link "view new posts".
The problem is that when I haven't come to dhammawheel for a long time, there is a lot of "new posts", and I can't read all of the new posts that interest me in a short time. In this case, I read some posts, and then I close my internet browser. If I come back to DW a few days laters, all these new posts are not longer considered as "new posts", and they disappear from the former list.
In other forums, I found a really usefull link next to the "new posts" one : it's called "unread posts". This is really usefull because a topic I haven't read will always be available through this link, until I read it or click on "mark forums read". I wonder if it would be possible for dhammawheel. What do you think ?

subset: commoncrawl


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Book Now
One-Bedroom Deluxe Apartments
(average size 90sqm/968sqft)
Your One Bedroom Deluxe Apartment comprises of a spacious living area with comfortable sofas and extraordinary views across Dubai. In addition to the master bedroom, which is complemented by a spacious en-suite bathroom with bathtub and shower, there is also a separate guest bedroom area with a queen size bed and an en-suite shower room. A fully equipped kitchen (electric stove, oven, dishwasher, refrigerator and microwave) and washing machine with integrated tumble dryer are also provided for your convenience. All units come with a balcony. All guests benefit from complimentary access to our Leisure Deck with swimming pool, fully equipped gym, childrens play area, pool bar and other leisure facilities. Also a supermarket, which sells fresh fruits, soft drinks, and other daily & household necessities, can be found adjacent to the Bonnington Hotel.
Services and facilities included in the rate:
- Private entrance and dedicated reception area
- 24-hour security guards and CCTV
- Swimming pool and other Leisure Deck facilities
- Use of the Hotel's restaurants, bars and lounges
- Two Housekeeping cleaning services per week
- 24-hour on call Concierge service
Services and facilities offered at additional charge:
- Baby-sitting service (prior reservation required)
- High-speed wired Internet access
- Laundry and dry cleaning services
- Use of the Hotel's Business Centre facilities
- Additional Housekeeping cleaning services
- 24-hour room service


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HOUSTON - A Yates High School student was sexually assaulted on her way home from her school.
"Even if you're not a parent, its somebody's worst nightmare to hear that a young child got raped for no reason," said Michael LaFleur, a father.
LaFleur said the recent sexual assault in his neighborhood has put him on edge, especially since he has a freshman daughter that attends the same high school.
The Houston police department is following up leads to catch the rapist.
The sexual assault happened on Wednesday. According to investigators, after the last school bell rang, the teenager left campus to get on a METRO bus. HISD said the girl waited at the bus stop to take her route home. After she stepped off the bus, police said she was raped.
"That's horrible. Yes, that's very unfortunate. I mean its unfortunate for any female who's sexually assaulted but definitely for someone who is still in high school," law student Syvondia Bailey said.
Bailey passes Yates High School every day to go to her law school's library, and said she's always on alert.
"Try not to walk by yourself, especially on the METRO bus. That's very unsafe," Bailey said.
"I would tell my daughter to be familiar with her surroundings. To be aware of everything around her at all times and to be on the lookout for people watching her," LaFleur said.
Even though LaFleur said he will talk to his daughter, he said someone from the school should have informed him of the reported crime sooner.
A HISD spokesperson said "We notify parents whenever we think there's a threat to our students. All of the facts indicate that this reported sexual assault has nothing to do with her connection Jack Yates High School."
According to the district, it is not involved because the incident happened off campus and the student took a METRO bus home, not a school bus.
Investigators do not have a description of the rapist.
Copyright 2012 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Kevin Westbrook...gotta love Quinn
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Kevin Westbrook...gotta love Quinn
Ian can't box out Love
A lot of bad misses.
Awful refs. You know the thug Love fouls too battling for a rebound
Last edited by Johanvil; 11-25-2013 at 08:45 PM.
He's naturally an aggressive shooter/scorer who's trying to walk the line between being aggressive and playing within the system. Same issues as a guy like Lance. On,y difference is OJ knows he's on,y gonna get 10-12 min MAX so his opportunities are very limited
Scola actually hasn't been terrible at the rim today, but what is with Pacers PFs missing at the rim in general?
Scott Foster hates the Pacers. Prick.
Refs are just hosing us right now
can't buy a foul to go our way....
Being unable to close out a game in which you have a comfortable lead in the 4th Q = Pulling a Frank Vogel
Lack of athleticism
Refs have been horrible! Have they called anything against Minny?
Sent from my iPhone using Tapatalk
3 terrible calls by the official all in a row, ridiculous.
You can't get champagne from a garden hose.
This is a ****ing sham.
yes Refs, thanks you for keeping Minnesota in the game. We appreciate it. ********
That ref has made two consecutive missed calls.
"We've got to be very clear about this. We don't want our players hanging around with murderers," said Larry Bird, Pacers president.
Refs keep this up, I bet someone in blue and gold gets ejected.
I actually like OJ as a bench energy guy going toward the rim. But he settles on too many jump shots, and he has the same issues as Lance does on the defensive end (tends to fall asleep, ball-watch, get caught under screens).
So basically, I don't disagree with the Lance comparisons. But he's Lance that can drive to the rim maybe 2-3 times per game tops, and obviously just not on the same level overall (especially on the boards, but TOTALLY unfair to compare any guard to Lance on the boards!)
We haven't given him a lot of PnP looks so far. He is struggling to finish at the rim in the last 2 seasons.
Tonight, all flags must burn, in place of steeples.
Autonomy must return into the hands of the people.
It will probably be the guy in the suit for the blue and gold
Sent from my iPhone using Tapatalk
Horrible bunch of inept refs.
The bench can't score.
Kevin Love complaining to the refs. Guy is ridiculous.
The Georges are playing well tonight.
J.J. Ba-ryant.
And1 Ian M.


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New Collectibles From Lost In Space, Aliens, Tomb Raider, Invincible, More...
This weekend, Toy Fair International begins at the Jacob Javits Center in New York City. Not open to the public, the event allows toy manufacturers to present their new offerings to buyers from retail stores around the world, and it always offers fans the first look at the hottest toys of the year. Well, this year Diamond Select Toys will once again be in attendance, and once again they will have plenty on display to dazzle fans.
On display will be new items from DST's broad array of licenses: Marvel Comics, Marvel Studios, The Walking Dead, Star Wars, Star Trek, Universal Monsters, The Munsters, Knight Rider, Ghostbusters, Pathfinder, Tomb Raider and Invincible. Products will include highly detailed 7-inch action figures, 2-inch Minimates mini-figures, Femme Fatales PVC statues, Granix art plaques, vehicles, light-up statues, banks, prop replicas, bottle openers, kitchenware, neon signs and more.
DST will also announce two new licenses at the show:
Lost in Space: The classic 1960s TV show, which updated "The Swiss Family Robinson" for the space age, will receive Minimates and an electronic replica of the B-9 robot.
Aliens: The 1986 science-fiction classic that drove the Alien franchise to new heights will receive Minimates and Minimate vehicles, as well as electronic vehicles of the Colonial Marines' military transports.
Stay tuned for our complete coverage!
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


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1989 Seagull Outboard Motor Prices and Values
Select Seagull Outboard Motors Models Below
Seagull Note
No longer in production.
(1997 - 1984)
British Seagull entered the marine industry in 1931 quickly grow to a major European company in the production of outboard motors. Sold in the United States as Seagull, the British made outboard marine motors were first sold in 1984. British Seagull products fell out of favor with boat owners as results from declining quality and the company's reliance on outdated technology. The 1997 model year would be the final time new Seagull outboard motors were available. British Seagull continues to operate only as a parts supplier to the many outboard motors produced over 66 years.


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I can adjust the time and date to any time between now until 30 days into the future.
But I have tentatively set the start of the Draft and Free Agency to Saturday 5/18 at 12pm EDT / 9am PDT only because the pre-set Draft Time and Date would have fallen on a Friday.
NOTE - We are not doing the Draft / Free Agency at this time...I only wanted to make sure that I set the Draft Time and date soemtime in the near future...not during a time that we won't be available.
I know that the Draft doesn't matter to most of you.....but since the Free Agency ( the only part of the Offseason that we care about ) starts right after that....We need to figure out a time and date to do this.


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Hunter Foster, Mamie Parris, Katie Thompson and More Star in Encores! Off-Center's PUMP BOYS AND DINETTES, Beginning Tonight
Pump Boys and Dinettes, the final production of the 2014 Encores! Off-Center series, stars Jordan Dean, Hunter Foster, Mamie Parris, Randy Redd, Katie Thompson and Lorenzo Wolff. Pump Boys, running today, July 16, through the 19th, is directed by Lear deBessonet and choreographed by Danny Mefford. Jeanine Tesori is the Encores! Off-Center artistic director; Chris Fenwick is the music director.
Pump Boys and Dinettes was conceived, written and performed by John Foley, Mark Hardwick, Debra Monk, Cass Morgan, John Schimmeland Jim Wann. The show is a musical tribute to life on the roadside, with the actors accompanying themselves on guitar, piano, bass, fiddle, accordion, and kitchen utensils. A hybrid of country, rock and pop music, Pump Boys is the story of four gas station attendants and two waitresses at a small-town dinette in North Carolina. It premiered Off-Broadway at the Chelsea West Side Arts Theatre in July 1981 and opened on Broadway on February 4, 1982 at the Princess Theatre, where it played 573 performances and was nominated for both Tony and Drama Desk Awards for Best Musical.
City Center's Encores! Off-Center series presents off-Broadway musicals that pushed creative boundaries when they were first produced. Filtered through the lens of today's artists, these shows are presented not as historical documents but as living, vital works that continue to resonate with audiences. In the Encores! tradition, Off-Center places a great emphasis on the scores, with the orchestra performing onstage. The series reflects City Center's ongoing outreach to new and younger audiences. In keeping with this mission, the majority of seats are $25.
New York City Center (Arlene Shuler, President & CEO), now in its 70th year, has played a defining role in the cultural life of the city since 1943. It was Manhattan's first performing arts center, dedicated by Mayor Fiorello La Guardia with a mission to make the best in music, theater and dance accessible to all audiences. Today, City Center is home to many distinguished companies, including Alvin Ailey American Dance Theater, City Center's Principal Dance Company, as well as Manhattan Theatre Club; a roster of renowned national and international visiting artists; and its own critically acclaimed and popular programs. The Tony-honored Encores! musical theater series has been hailed as "one of the very best reasons to be alive in New York." In summer 2013, City Center launched Encores! Off-Center, a new series featuring landmark musicals filtered through the lens of today's most innovative artists. Dance has been integral to the theater's mission from the start, and dance programs, including the annualFall for Dance Festival, remain central to City Center's identity. Vital partnerships with arts organizations including Jazz at Lincoln Center and London's Sadler's Wells Theatre enhance City Center's programmatic offerings. City Center is dedicated to providing educational opportunities to New York City students and teachers with programs such as Encores! In Schools and the Young People's Dance Series. Special workshops cater to families, seniors and other groups, while events such as the Fall for Dance DanceTalk series offer learning opportunities to the general public. In October 2011, City Center completed an extensive renovation project to revitalize and modernize its historic theater.
Pump Boys and Dinettes will play five performances, today, July 16, through July 19 as follows: Tonight, July 16 and Thursday, July 17 at 7:30 pm; Friday, July 18 at 8 pm; Saturday, July 19 at 2 and 8 pm. All tickets begin at $25 and can be purchased at the New York City Center Box Office (West 55th Street between 6th and 7th Avenues), through CityTix at 212-581-1212, or online at www.NYCityCenter.org.


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New Toys, Comics and One-of-A-Kind Prizes at SDCC 2012...
Be sure and enter Sideshow's SDCC Captain American Bucky Barnes Premium Format Figure Giveaway!
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, RedfordFilms.com, Toynk.com, PastGenerationToys.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.
For action figures, statues and sculptures, go to CSMooreStudio.com.
At San Diego Comic-Con, Diamond Select Toys launched their latest original property, Battle Beasts, across multiple platforms, including toys, comics, animation and music.
The first Battle Beasts toys, utilizing Diamond Select's Minimates mini-figure body, went on sale at Comic-Con, in the form of a two-pack featuring protagonist Vorin and a show-exclusive character, Zik. Additionally, 200 clear blue figures of Vorin were given out to attendees each day of the show, continuing DST's long tradition of giving out promotional Minimates at every Comic-Con. The first full series of Battle Beasts, due out in December, was also on display at the DST booth.
Wednesday's Preview Night also saw the debut of the first issue of IDW's Battle Beasts mini-series, based on concepts and designs by Diamond Select. A variant cover depicting the San Diego Convention Center was exclusively available at the show, and writer Bobby Curnow and cover artist Ulises Farinas participated in a signing at the DST booth, where they gave out free posters and ashcan comics.
A drawing was also held at the DST booth for a custom Battle Beasts HP Special CG guitar by Peavey, as well as a matching airbrushed guitar case by Coffin Case. Both the guitar and the case featured artwork from Dan Brereton's cover to Battle Beasts #1, and both were on display at the DST booth during the show.


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Danfoss Metal Drive Sleeve for Series 90 Motor Actuators
The Danfoss Global Group is a renowned leader in research, development, production, sales and services of mechanical and electronic components for a wide variety of industries. Their dedication to reach goals with a minimal consumption of raw materials and energy, have the least possible impact on the environment and make the most efficient use of resources has made them one of the most sought after brands globally. They have a long tradition for social responsibility towards everyone involved in the industry; clients, customers, employees and the surrounding environment. By being active in sustainable global development, Danfoss understands that social and environmental responsibility and climate considerations go hand-in-hand with healthy business development.
The 25413 is the Metal Drive Sleeve for Series 90 Motor Actuators.


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Observational Study on Predictors of Response to Invirase (Saquinavir) Treatment in Treatment-naïve Patients With HIV Infection
This study has been completed.
Hoffmann-La Roche
Information provided by (Responsible Party):
Hoffmann-La Roche
ClinicalTrials.gov Identifier:
First received: February 15, 2011
Last updated: November 1, 2016
Last verified: November 2016
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This prospective observational study will evaluate predictors of response to Invirase (saquinavir) treatment in treatment-naïve patients with HIV infection. Data will be collected during 48 weeks of treatment.
|HIV Infections
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Prospective Multicentre Noninterventional Observational Study on Predictors of Treatment Response in a Cohort of Treatment naïve HIV-infected Patients Treated With Saquinavir (PROSPECTOR)
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Saquinavir Saquinavir mesylateU.S. FDA Resources
Further study details as provided by Hoffmann-La Roche:
Primary Outcome Measures:
- Predictive value of baseline CD4 count and HIV RNA on virological and immunological response at 12, 24 and 48 weeks of treatment [ Time Frame: 48 weeks ]
Secondary Outcome Measures:
- Host- and virus-related factors influencing virological and immunological response at 12, 24 and 48 weeks of treatment [ Time Frame: 48 weeks ]
|Study Start Date:
|August 2010
|Study Completion Date:
|September 2013
|Primary Completion Date:
|September 2013 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Study Population
Treatment-naïve HIV-infected patients initiated on treatment with Invirase
Inclusion Criteria:
- Adult patients, >/= 18 years of age
- HIV infection
- Treatment-naïve
- Initiation of treatment with Invirase
Exclusion Criteria:
- Contraindications according to Invirase Summary of Product Characteristics
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01297127
Please refer to this study by its ClinicalTrials.gov identifier: NCT01297127
|Bialystok, Poland, 15-540
|Bydgoszcz, Poland, 85-030
|Chorzow, Poland, 41-500
|Krakow, Poland, 31-531
|Lodz, Poland, 91-347
|Warszawa, Poland, 01-201
|Wroclaw, Poland, 53-208
|Zielona góra, Poland, 65-045
Sponsors and Collaborators
Hoffmann-La Roche
|Study Director:
|Clinical Trials
|Hoffmann-La Roche
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Hoffmann-La Roche
|ClinicalTrials.gov Identifier:
|NCT01297127 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 15, 2011
|Last Updated:
|November 1, 2016
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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Get an overview of this hotelBeachfront luxury resort on secluded beach
Popular property highlights
On a sandy beach
The Kahala Hotel & Resort is located on a secluded crescent beach in the exclusive Kahala area of Honolulu, only 4 miles from Waikiki Beach.
Swim with dolphins
Guests at the Kahala can swim and interact with the hotel's dolphins, who share residence with exotic fish and sea turtles in a 26,000-square-foot saltwater lagoon.
Ocean view
Rooms at this luxury Honolulu hotel offer hand-woven Tibetan carpets, teak floors, and mahogany furnishings. Sliding-glass doors open to stunning views of the Pacific Ocean, Ko'olau Mountain Range, Diamond Head and Koko Head craters, or the Dolphin Lagoon.Information missing or incorrect? Tell us!Opens in a new window
The Kahala Hotel & Resort
Hotel Amenities
Hotel Amenities
The Kahala Hotel and Resort is composed of 2 10-story towers and a 2-story Dolphin Lagoon Terrace. A 3-story lobby provides plush seating amid white beams, tall drapes, and wooden shutters.
Every imaginable facility and service is available for a relaxed, luxurious vacation: a fitness center offering personal training, aquatic exercise, and yoga, with separate men's and women's quarters with saunas, steam rooms, and spas; a Keiki Club for children ages 5–12, offering half- and full-day sessions of Hawaiian culture and activities; exclusive shops and boutiques; complimentary shuttles to nearby shopping; beach cabanas with food and beverage service (surcharge); and complimentary activities such as seasonal Hawaiian cultural programs. Garage parking is available on site (surcharge) and complimentary wireless high-speed Internet access is available.
The Kahala Hotel offers fine cuisine and drinks through 5 restaurants and bars. Hoku's restaurant consistently wins acclaim for its contemporary Island cuisine, which melds Hawaiian, Asian, and European flavors. For classic burgers and drinks, relax at the Seaside Grill. Italian and Mediterranean venues are on site, as well as a lovely poolside bar serving drinks. Live piano music fills the room each night from Tuesday to Saturday at The Veranda. Enjoy cocktails and late night snacks, and perhaps a twirl around the dance floor.
The Kahala Spa with garden view boasts a suite of 9 spacious treatment rooms — each with their own relaxation area, glass-enclosed shower and deep soak tub. The Kahala Spa Signature Massages and Rituals all begin with the ritual of Ho'omaka, a cleansing and relaxing foot massage. Guests can choose from a wide variety of treatments including aromatherapy treatments, body scrubs, body wraps, facial treatments, manicures and pedicures. Couples treatments and bridal or birthday spa parties may also be reserved. The spa also has a boutique.
- Free WiFi
- 24-hour front desk
- Babysitting or childcare (surcharge)
- Children's club (surcharge)
- Supervised childcare/activities (surcharge)
- Airport transportation (surcharge)
- ATM/banking
- Valet parking (surcharge)
- Number of bars/lounges - 2
- Breakfast available (surcharge)
- Concierge services
- Conference space
- Dry cleaning/laundry service
- Free newspapers in lobby
- Elevator/lift
- Fitness facilities
- Full-service spa
- Free shopping center shuttle
- Gift shops or newsstand
- Pool umbrellas
- Laundry facilities
- Total number of rooms - 338
- Luggage storage
- Number of floors - 10
- Spa treatment room(s)
- Meeting rooms
- Multilingual staff
- Garden
- Picnic area
- Poolside bar
- Porter/bellhop
- Safe-deposit box at front desk
- Conference space size (meters) - 1208
- Number of meeting rooms - 2
- Free area shuttle
- Number of restaurants - 5
- 24-hour business center
- Conference space size (feet) - 13000
- Self parking (surcharge)
- Direct access to private beach
- Beach umbrellas
- Beach cabanas (surcharge)
- Beach sun loungers
- Pool sun loungers
- Beach towels
- Sauna
- Shopping on site
- Spa services on site
- Steam room
- Spa tub
- Children's pool
- Outdoor pool
- Wedding services
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Children's pool
- Free Wi-Fi
- Area shuttle (complimentary)
- Laundry facilities
- Babysitting or childcare (surcharge)
- Refrigerator
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi , Free wired Internet
Available in some public areas: Free WiFi
Self parking (surcharge), Valet parking (surcharge)
Room Amenities
- Free WiFi
- Premium TV channels
- Pay movies
- Air conditioning
- Refrigerator
- Separate sitting area
- Free newspaper
- Ceiling fan
- Hair dryer
- Bathrobes
- Designer toiletries
- Premium bedding
- Hypo-allergenic bedding available
- Phone
- Coffee/tea maker
- In-room safe
- Free bottled water
- Daily housekeeping
- Turndown service
- Private bathroom
- Free toiletries
- Slippers
- Separate bathtub and shower
- Deep soaking bathtub
- Desk
- Iron/ironing board
- Cable TV service
- Free wired Internet
- In-room massage available
- Room service (24 hours)
- Free cribs/infant beds
- Connecting/adjoining rooms available
- Rollaway/extra beds (surcharge)
Where to Eat
Hoku's - Hoku's consistently wins acclaim for its contemporary Island cuisine, which melds Hawaiian, Asian, and European flavors prepared with finesse and served with style. The hotel features bright furnishings, Italian bone china, and Christofle silver. Thanks to a multi-level layout, all diners receive ocean-view seats, but may be distracted from the view by the open kitchen featuring fiery hot woks, a kiawe wood grill, and tandoori and wood-burning ovens. Hoku's serves dinner and Sunday brunch.
Arancino at the Kahala - Italian restaurant serving lunch, dinner, and drinks. Children's menu and al fresco dining is available.
Plumeria Beach House - Renowned for its Kahala Burger, this casual beachside café features bountiful buffets and off-the-menu choices for breakfast, lunch, and dinner, with live Hawaiian music at sunset.
The Veranda - Designed in classic plantation style, the comfortable lounge overlooks the Dolphin Lagoon with a choice of both indoor and al fresco seating. Afternoon Tea is a tradition, after a day out discovering Oahu. It is also a popular venue for special occasions and showers.
Seaside Grill - With a direct view of the Pacific Ocean, this restaurant is perfect for lunch or afternoon cocktails. Also features classic burgers, sandwiches, and salads.
Room service is available 24 hours.
Nearby Things to Do
Guests can spend their time at The Kahala Hotel & Resort doing a range of activities, including beach yoga, pilates and swimming at the hotel's private beach.
The recreational activities listed below are available either on site or near the hotel; fees may apply.
- Snorkeling nearby
- Personal motorized watercraft on site
- Water skiing nearby
- Parasailing nearby
- Skydiving nearby
- Windsurfing nearby
- Kayaking nearby
- Sailing nearby
- Surfing/boogie boarding nearby
- Golfing nearby
- Mountain biking nearby
- Hiking/biking trails nearby
- Scuba diving nearby
- Free bicycles on site
- Pilates classes on site
- Yoga classes/instruction on site
- Beach yoga on site
Spa Services
- Swedish massage
- Number of treatment rooms 10
- Manicures and pedicures
- Body wraps
- Body scrubs
- Aromatherapy treatments
- Spa tub in spa
- Massages
- Minimum age to access spa is 13
- Body treatments
- Facial treatments
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- Roll-in shower
- In-room accessibility
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Minimum check-in age is 18
Check-in time starts at 3 PM
Special check-in instructions:
Check-out time is noon
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Children and extra beds
- Children are welcome.
- Kids stay free! Children 17 years old and younger stay free when using existing bedding.
- Rollaway/extra beds are available for USD 75.0 per day.
- Free cribs (infant beds)!
- Pets allowed for an extra charge of USD $150.00 per accommodation, per stay
- Dogs only
- 1 per room (up to 25 lb)
- Restrictions apply
- For more information contact the property at the number on the booking confirmation
You need to know
Extra-person charges may apply and vary depending on property policy.
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- Fee for buffet breakfast: USD $38.00 per person (approximately)
- Airport shuttle fee: USD $185 per vehicle (one-way)
- Self parking fee: USD 32 per night
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- Rollaway bed fee: USD 75.0 per day
Hotel Name
- Kahala Hotel & Resort
- Kahala Resort Hotel
- Kahala Hotel Resort
- The Kahala Hotel Honolulu
- The Kahala Hotel And Resort
- Kahala Resort Honolulu
- Kahala Hotel Honolulu
- Mandarin Oriental Oahu
- Kahala Mandarin Oriental
- The Kahala Hotel & Resort Hawaii/Honolulu
We should mention
Reservations are required for massage services and spa treatments. Reservations can be made by contacting the resort prior to arrival, using the contact information on the booking confirmation. Children 17 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation. Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation (surcharges apply and can be found in the Fees section).
Awards & Affiliations
- The property is a member of Preferred Hotels & Resorts.


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Children in homeless shelters mostly young, says new report
Last year, more than 9,000 homeless children spent time in Pennsylvania shelters. Almost 60 percent were younger than five.
These numbers come from a new report published by the People's Emergency Center (PEC), a West Philadelphia non-profit.
Staci Perlman, a visiting scholar at PEC and an associate professor at the University of Delaware noted that while 5 percent of kids in Pennsylvania are under the age of one, they represented 12 percent of children who spent time in emergency and transitional housing in 2012.
"That means," said Perlman, "that some of our youngest citizens are spending at least some portion of their earliest and arguably most important developmental years without stable housing."
Ages of children in temporary housing also varied across regions.
"I thinking increasingly children are being recognized as having their own sets of needs," said Perlman.
Shelter operators, she believes, are becoming more strategic about how to work with the children who arrive with their parents and how to support their developmental challenges.
Perlman acknowledges these figures cover only a subset of homeless children. Older kids and teens in particular are more likely to couchsurf between homes of friends and family rather than stay in a shelter.
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ARP Engine & Accessory Fastener Kit Hex Head Stainless Steel
Product Details
It's easy to assemble a show-quality engine when you use ARP's handy Engine & Accessory Fastener Kit. Virtually everything you need comes completely organized in one convenient package (no need to deal with twelve different part numbers)! More importantly, each and every fastener is superior in strength to the OEM bolts, and also significantly better than hardware grades (even Grade 8). You have a choice of two premium quality materials and finishes.
Traditionalists will appreciate the strength and functionality of ARP's heat-treated 8740 Chrome Moly steel alloy bolts, which feature a black oxide finish.
Those who desire a dazzling engine will no doubt prefer fasteners made of ARP's specially alloyed Stainless 300 material, which has the added benefit of being virtually impervious to rust and corrosion. The stainless steel is polished to achieve a brilliant luster, and provides a distinctive, maintenance-free environment.
Each kit has a dozen different type fasteners, all neatly organized and labeled in protective vacuum-wrapped packages. Both materials are nominally rated at 170,000 psi tensile strength and come in both hex and 12-point heads. Please note that these kits are designed for carbureted engines. Newer EFI applications may require the purchase of additional fasteners.
- Engine & Accessory Fastener Kit Hex Head
- Material: Stainless Steel
Images used may be generic. Actual product may vary.
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A few months ago a syndicated columnist, Anica Wong of Creators.com gave us a call at Vermont Woods Studios Furniture to ask, "What's so eco-friendly about your furniture?" It's a great question especially since there is so much green-washing out there. It seems that every furniture brand and furniture store is now hitting the "organic, sustainable furniture" theme in their advertisements, regardless of their environmental policies.
So anyway I told Anica that Vermont Woods Studios is not a furniture company that suddenly "went green". Actually we're a bunch of trehuggers that partnered with some of Vermont's best fine furniture makers to create a company that delivers handcrafted, Vermont-made, eco-friendly furniture to customers all across the USA. She then asked all about our story and wrote a nice article that is being syndicated in several newspapers like this one, The Calgary Herald. Check it out. And many thanks to Anica for including us in her story!
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This blog is written by your friends at Vermont Woods Studios. Check out our Vermont made furniture and home decor online and visit our showroom and art gallery at Stonehurst, the newly restored 1800s farmhouse nestled in the foothills of the Green Mountains.


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Rick Haglund: College Affordability Pays Off in Unexpected Ways (Listen Up, State Government)
Rick Haglund: College Affordability Pays Off in Unexpected Ways (Listen Up, State Government)
June 02, 2013/Mlive
By Rick Haglund
Higher education has few friends in state government.
Appropriations to the state's 15 public universities were cut annually for a decade, although they received a slight increase this year.
While providing less financial support, lawmakers have not hesitated to meddle in the affairs of universities that are granted autonomy under the state constitution.
Legislatures and governors around the country are even questioning the value of large, public research universities, which produce about 70 percent of the nation's engineers, scientists and physicians.
I'm not suggesting that these universities should be immune to debate about their governance and financing.
College affordability is a huge problem that needs to be addressed. While cutting public funding doesn't help, even experts such as former University of Michigan President James Duderstadt acknowledge that universities must do a better job of controlling costs.
But in the squabbling about how money is spent, we lose sight of the special role universities, especially large research institutions, play in improving life in our state.
In one recent example, U-M researchers and surgeons performed an incredible medical breakthrough that involved biomedical engineering, cutting-edge manufacturing and entrepreneurial speed in a life-saving surgery.
Can't ask for much more than that, can we?
In case you missed this fascinating story, here's what happened:
Kaiba Gionfriddo, an Ohio infant, suffered from a rare disorder that caused his airway to collapse when he tried to breathe.
"He was imminently going to die," said Glenn Green, an associate professor of pediatric otolaryngology at U-M.
In February 2012, Green and colleague Scott Hollister, a biomedical and mechanical engineer and associate professor of surgery, built a plastic windpipe using 3-D printing and implanted it in Kaiba's throat.
The first-of –its-kind procedure was revealed last month in the New England Journal of Medicine.
A 3-D printer works somewhat like an ink jet printer. But instead of squirting ink, the 3-D printer shoots layers of plastic into a pre-determined shape.
Green and Hollister obtained emergency approval from the Food and Drug Administration to implant the device.
Kaiba, now 20 months old, is doing well and no longer "turning blue," said his mother, April.
Beyond saving lives, universities also give a big, but often-unappreciated boost to Michigan's economy.
Michigan's three largest research universities—U-M, Michigan State University and Wayne State University—generated $15.5 billion in statewide economic impact last year.
That's nearly as much as the $17.7 billion in economic impact claimed by the state's tourism industry.
The state's economic development agency regularly churns out news releases on companies that create jobs with the help of state incentives.
But there is little recognition of the benefits of state-funded universities, which boost the economy, save lives and make Michigan a better place to live.
Email Rick Haglund at email@example.com
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Baileys Crossroads Planning Study Existing Conditions Report
The consultant team has completed the Existing Conditions report for the Baileys Crossroads Planning Study. The executive summary and the entire report are available for download separately. Please note that entire report is a large document and may be slow to download.
If you would like a hard copy of the report or have any questions, please call 703-324-1380, TTY 711, or send an e-mail to the Baileys Crossroads Planning Study at email@example.com
Please note that the report may be slow to download due to its size.


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Over 50 custom 8" DIY Qees
For a great selection of action figures and collectibles, check out BigBadToyStore.com, Urban-Collector.com, BriansToys.com, DollsAmerica.com, ClarkToys.com, ToyWiz.com, VNCToys.com, PastGenerationToys.com, MonkeyDepot.com, RPMDiecast.com, HobbyLinkJapan.com, YesAnimation.com, and SuperheroToys.com.
For a great selection of pop culture t-shirts and apparel, check out TShirtGurus.com and 80sTees.com.
Sideshow Collectibles teases fans with a sneak peek look at their first Indiana Jones polystone diorama: Indiana Jones vs. Mola Ram as seen in "Temple of Doom". Pre-orders for this sure to be powerful sculpture begin October 8th with the launch of Sideshow's newsletter. Stay tuned right here for full details, images and ordering info.
Toy2R provides video recap from their We Ain't Plastic Qee Exhibit held at The Public in Lincoln, Nebraska on October 2nd, 2009.
Over 50 custom 8" DIY Qees were displayed from more than 50 artists from the Lincoln and Omaha area with special guest artists from across the country. Check out the awesome designs at the video link below...


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The Effect of General Anesthesia on the Risk for Arrhythmia (10-02725)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Polymorphic ventricular tachycardia, known as Torsades de Pointes (TdP), is a specific form of ventricular arrhythmia with a characteristic twist of the QRS complex around the isoelectric baseline. TdP can degenerate into ventricular defibrillation followed by sudden cardiac death. A predictor for the development of TdP is the length of the QT interval measured on an EKG recording. The QT interval is known to be prolonged by many medications used in a perioperative setting as well as by other conditions such as hypothermia and electrolyte imbalance. General anesthesia exposes most of the investigators patients to a combination of several of those medications and conditions and therefore might increase the risk for the development of QT prolongation. Moreover, patient related risk factors are well known and aggravate the individual risk for potential life threatening TdP events when exposed to QT prolonging medications perioperatively.
Previous research suggests that more than 20% of the patients might develop QT prolongations perioperatively and are consequently on an increased risk for TdP; yet, no study has systematically investigated the magnitude of the problem and associated risk factors.
The proposed pilot study is designed as a prospective observational cohort study to investigate the QT interval before, during and after general anesthesia. It aims to determine the incidence of perioperative QT prolongations. A customary long term EKG recording device will be connected to a random sample of patients undergoing general anesthesia. Using these continuous EKG tracings, the lengths of the QT interval will be analyzed during the perioperative period.
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|The Effect of General Anesthesia on the Risk for Arrhythmia -A Pilot Study
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Inclusion Criteria:
- Male and female ASA I - III patients
- Age 18 years and older
- Scheduled for general anesthesia with a duration of at least 1 hour
Exclusion Criteria:
- Cardiac or thoracic surgery
- Planed postoperative ICU admission
- Non-English speaking
- Not in sinus rhythm
- Left and right bundle branch block
- Implanted pacemaker
- Mentally impaired
Please refer to this study by its ClinicalTrials.gov identifier: NCT01174251
|United States, California
|UCSF Medical Center (Moffitt/Long, Mt. Zion)
|San Francisco, California, United States, 94143
|Principal Investigator:
|Kerstin Kolodzie, M.D., PhD
|Dept. of Anesthesia & Perioperative Care; University of California, San Francisco (UCSF)
|Responsible Party:
|University of California, San Francisco
|ClinicalTrials.gov Identifier:
|NCT01174251 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 30, 2010
|Last Updated:
|October 7, 2013
Keywords provided by University of California, San Francisco:
general anesthesia
long QT syndrome, acquired
Additional relevant MeSH terms:
Central Nervous System Depressants
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


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Dutch men's basketball team outlasts Sacred Heart
SAN JUAN, PUERTO RICO—The Central College men's basketball team was consistently in front and outlasted tournament host Sacred Heart (P.R.) 81-72 Sunday afternoon at San Juan, Puerto Rico.
The Dutch (7-4 overall) led by nine points at halftime (41-32) and played even in the closing frame (40-40) for the win. Central outrebounded Sacred Heart 49-32, including 20 offensive boards leading to 24 second chance points, and totaled 20 assists to set the pace.
"Sacred Heart is a good team," coach Craig Douma said. "They've played some top-ranked teams tight this season, so it's a quality win. They are talented and athletic, but we did a great job rebounding the ball, particularly on the offensive end. Second chance points were the difference."
Forward Matt Greenfield (senior, Huxley, Ballard HS) had a double-double at halftime and finished with 22 points on 9-of-19 shooting and hauled in a career-high 17 rebounds. Frontcourt teammate Colby Taylor (freshman, Creston) made his second career start and connected on 5-of-8 3-pointers en route to a career-high 16 points and grabbed six rebounds.
"Matt played a very active game," said Douma. "He was inside, outside and all over the glass. He was definitely a leader on the floor today. Colby shot the ball very well. He played a major role in opening up the inside with his outside shot."
Guard Nile Eckermann (junior, Cosgrove, Clear Creek Amana HS), typically known for his scoring, tallied a career-high seven assists in addition to five points and four rebounds. Center Spencer Bakerink (senior, Creston) scored nine points on 4-of-5 shooting and snagged six boards.
Central shot 45.7 percent from the field (32-of-70) and netted nine 3-pointers. In total 10 Dutch players scored at least two points, with six players connecting on two field goals apiece.
"It was a good game for us overall," Douma said. "The scoring was spread out, which was important. We could never completely break away from Sacred Heart, but we were consistently ahead and able to leave here with two wins."
Central breaks for more than one week before opening Iowa Conference action against last season's conference co-champion Luther College (7-3 overall) Jan. 8 at Pella. Last season the Norse swept the two-game series, including a 72-66 overtime win at Decorah, en route to a share of the league title.Print this ad for $10 off your next oil change


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Amy Butler
Amy Butler is a creative designer known for her sophisticated yet relaxed modern approach to printed fabrics and products for home, fashion and craft. With spirited color and confident combinations of print, Amy's fresh point of view is apparent in all of the products she creates. As a sewing pattern designer, she has brought modern styling to the sewing arts and inspired a new generation of young women to "Find their own style."
With millions of hits a month on her website and numerous editorial appearances, Amy's growing brand has become synonymous with creativity, sustainability, quality and great style. Amy works from her studio in Central Ohio with her husband, cats and a small staff of amazing friends. Her fabrics, patterns, handbags, design and project books & home decor products are sold worldwide.


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APTOS-- California Highway Patrol officers arrested a Felton man on suspicion of several charges after a hit-and-run accident Tuesday.
Officers responded to a traffic collision on southbound Highway 1 near Capitola Avenue around 3:30 p.m. in which a green vehicle rear-ended another car driven by a Wisconsin woman. She was uninjured, but told officers the other driver had fled.
Not long after, CHP officers spotted a 1999 green Subaru Forester near the intersection of Park Avenue and Cabrillo College Drive, officer Sarah Jackson said. The car had front-end damage, steam was coming from the hood, and the driver, Todd Buglione, had apparently run out of gas.
While speaking with Buglione, 38, an officer observed drug paraphernalia in the Subaru. A struggle ensued between Buglione and the officer, Jackson said, and another officer had to deploy his stun gun to subdue Buglione.
Buglione was treated for minor injuries suffered in the struggle at Dominican Hospital, and was then booked into Santa Cruz County Jail on suspicion of four misdemeanors for possession of drug paraphernalia, driving with a license suspended for a prior DUI, resisting arrest and hit-and-run without causing injury.


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Scanlation Group
Free forum : A forum meant for discussions of all sorts.
free, #mystic, forum, games, anime, dragon, ball, inuyasha, fullmetal, alchemist, full, trigun, hellsing, bleach, final, emblem, call, duty, halo, fantasy, fire, video, street, fighter
Mystic Shadows is a modern dark fantasy role play. Were magic and monsters are common and nightmares lurk.
free, forum, #mystic, shadows, dark, fantasy, paranormal, occult


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Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Avoid with a known allergy to soy, any of its parts, or members of its plant family.
Soy may act as a food allergen similar to milk, eggs, peanuts, fish, and wheat. Symptoms of an allergic reaction range from a runny nose, to inflammation of the digestive tract to a sudden drop in blood pressure.
Soy is likely safe when used in the diet in adults, children, and infants, although maximum duration is unknown. Soy protein has been safely used for up to one year. Soy formula has been safely used in full-term infants.
Soy may cause atopic eczema (skin problems), asthma, bad taste, bleeding, bloating, constipation, damage to pancreas, diarrhea, goiters (enlarged neck due to increased thyroid size), growth failure, fatigue, immune changes, increased heart rate, insomnia, intestinal inflammation, loose stool, menstrual changes, migraine, nausea, stomach pain, and vomiting.
Use cautiously in people with hormone-sensitive cancers such as breast, ovarian, or uterine cancer, or hormone-sensitive conditions such as endometriosis.
Soy may increase the risk of bleeding. Caution is advised in people with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.
Soy may lower blood sugar levels. Caution is advised in people with diabetes or low blood sugar, and in those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.
Soy may cause high blood pressure. Caution is advised in people taking drugs or herbs and supplements that alter blood pressure.
Because soy contains estrogen like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.
Soy may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system.
Use cautiously in people who have anemia, cystic fibrosis, or disorders of the thyroid, stomach, intestine, immune system, or heart.
Avoid soy at levels higher than normally consumed in food if the person is pregnant or lactating, has cancer or is at risk for cancer, or is taking medications.
Soy as a part of the regular diet is traditionally considered to be safe during pregnancy and breastfeeding, although scientific research is limited in these areas.
Recent study demonstrates that isoflavones are transferred through breast milk from mothers to infants. In non-human study, high doses of isoflavones resulted in tumors and reproductive changes in offspring. Avoid high doses of soy or soy isoflavones in humans.
Portions of this document last updated: Nov. 01, 2013
This evidence-based monograph was prepared by The Natural Standard Research Collaboration
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When 15-year-old Kim Vesco moves from Chicago to Salem, Massachusetts, she finds the local student body is divided into rival factions of witches and non-witches, with both sides bidding for her allegiance. And if that weren't enough, an unknown force seems to want her — dead! Between the tribal loyalties of the schoolyard and the brutal, fight-or-die logic of the mage-war, Kim must steer a course that will keep her alive until she can take the fight back to her enemy and reveal the true identity of someone she thought she already knew: herself. Collecting Spellbinders #1-6, written by Mike Carey, pencilled and with a cover by Mike Perkins.Marvel, paperback, 144 pages, published June 2012
This product was added to our catalog on Tuesday 03 April, 2012.
Maldon, Essex
Phone: 01621 877222
Copyright FPI © 2017All Rights Reserved


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Derek Sivers is the man who created CD Baby. He posted an interesting article on his blog on some of what went on behind the scenes as Steve Jobs created iTunes. It shows another case of music industry battle. I think we are lucky that Tunecore was able to strike and promote a good way to get Independent music into the iTunes music store. I know there are other ways in but imagine if underground artists were locked out.
"I decided to refund everybody's $40, with my deepest apologies. With 5000 musicians signed up, that meant I was refunding $200,000. Since we couldn't promise anything, I couldn't charge money in good conscience." – sivers.org
Read the full article: http://sivers.org/itunes


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Is Justin Timberlake Going to Release New Music With Jay-Z and Beyonce Today?
If you want to interpret a cryptic tweet issued by the-long-absent-from-making-music-while-he-stars-in-romantic-comedies Justin Timberlake, he just might be making his much anticipated return to music. Rumor has it that a long-rumored collabo with Jay-Z and Beyonce is in the works. Say what?!
According to Complex, the rumor began with Florida's Radio Now 97.9, which suggested that the single will be released shortly.
Now things have caught fire a bit in terms of the who, the what and the when.
Last night, JT tweeted today's date, referencing the very specific time of 9:01AM PT. So we know we have to watch out for something at that time. Will it be the single that is released to radio or via DSPs at that very moment? Could be. What a tease.
Thursday, January 10th, 2013 at 9:01 am PST…
— Justin Timberlake(@jtimberlake) January 10, 2013
But that's not all, JT fans.
Apparently, he has recorded a full album that was produced by Timbaland, which was rumored and reported, and then shot down by his publicist, who flat out denied that he was working on music, back in August. Billboard reports that 20 tracks have been recorded. A source close to the situation also said the singer will be releasing music soon. Perhaps he watched and rewatched this PSA, where fans pleaded for him to make his return.
Beyonce also mentioned in GQ about working with JT, in addition to Pharrell, Timbaland and The-Dream.
We're a little skeptical, but also incredibly hopeful. Hurry up 9:01AM PT and get here!
Timberlake's last album 'Future Sex/Love Sounds' came out in 2006, which is too long ago.
Watch the Justin Timberlake 'Sexy Back' Video
Subscribe to 92 Moose on


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James Bond, Princess Bride, Dracula, more...
San Diego Comic-Con coverage brought to you by Collectibles Insurance, Big Bad Toy Store, Sekaido, and Monkey Depot.
Factory Entertainment made a splash at Comic-Con with a booth packed with cool movie replicas - both for sale and display. The latter was a collection of original screen-used props from various James Bond movies, including a Faberge Egg from Octo***** and Laser Rifle from Moonraker. While these were just for show, Factory Entertainment did have some 007 prop replicas for sale. These included a 1:1 scale replica of the Golden Gun from The Man with the Golden Gun (pictured above) and a cast replica of the metal teeth worn by the Bond villain "Jaws". Read our story HERE for full details on both these items.
Other items on display included licensed sword replicas from The Princess Bride, replica rings from Dracula, and items from The Green Hornet, including upcoming prop replicas of the Hornet's Gas Gun and Kato's Dart and TV series based action figures (above).
CLICK HERE for a Factory Entertainment SDCC photo gallery tour!


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NEW YORK ( TheStreet) -- Michael Dell has good reason to take Dell ( DELL) private.The public investor doesn't value it. Dell may be down but it's not broke. It still makes money. It has operations around the world and is re-focusing on cloud computing and computer services. It has growth prospects. By taking his company private Dell can focus on those growth prospects without worrying about quarterly earnings, and without having to talk to people like me ever again. Many of our greatest companies are privately held, Forbes notes, from Cargill to Mars to Bechtel. With annual sales of $60 billion, Dell would be number three on the 2012 Forbes list.
Rival Hewlett-Packard's ( HPQ) reaction to this was a big nyaah-nyaah-nyaah, telling ComputerWorld confidently it's going to steal a bunch of Dell's customers due to all this "uncertainty." But if any company on the planet should be concerned about a private equity takeout, it's HP. While the equity value of Apple ( AAPL) and Microsoft ( MSFT) is more than twice their annual sales, and that of Google ( GOOG) nearly five times more, HP's equity is worth barely more than one-quarter its annual sales. That's worse than retailers Target ( TGT) and Costco ( COST). It's worse than Dell. Quartz reports that some on HP's board are now considering breaking the company apart, and HP management told Business Insider last month it might unload some weaker divisions.
The trouble is, HP is nothing but weak divisions. Jon Xavier of Silicon Valley Business Journal recently ticked off the company's weak sisters and found himself listing the whole company. There is value in HP, even if it's breakup value. Like an NBA team with expiring contracts, it can dump salary in the form of losses others could write off. The company's official turnaround strategy, from an October press release, is to focus on cloud technology, data security and something called "information optimization." Mostly it's about using software to sell hardware, which is what Oracle ( ORCL) is doing. Only Oracle's database software is essential to its customers in ways HP's software simply isn't. Speaking of Oracle, it is just one of several rivals that now have the power to buy HP, sell off the stuff that doesn't work and pocket the rest. Oracle's market cap is $167 billion, Microsoft's is almost $230 billion, IBM's ( IBM) is almost $227 billion. Contrast that with HP's $33.5 billion.


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The Greek government is teetering on the brink of collapse Thursday, following the decision of Prime Minister George Papandreou to call off a referendum on the Europe bailout package for his country. The finance minister and other party colleagues have turned against Papandreou, amid talk of a national coalition government to prepare for new elections. Guy Raz talks to Joanna Kakissis, who has the latest from Athens.
Papandreou Nixes Referendum On Bailout
By editor • Nov 3, 2011


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At best, he'd be the 1st Guard off the bench....but we have Lance to do that...and can do a passing imitation of being a decent ball handler and emergency backup PG if needed. I don't think that Ben could do that.
I can see Bird being interested in after he becomes a UFA in the 2014-2015 season...but not at his current price.


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AUBURN, Ala. (AP) - Jarnell Stokes had 20 points, seven rebounds and seven assists to help Tennessee rout Auburn 82-54 on Wednesday night.
The Volunteers (19-11, 10-7) were up 24 points at halftime and never gave the Tigers (13-15, 5-12) a glimmer of hope after the opening minutes for their third straight win.
Stokes was 8-of-10 shooting for Tennessee, which is trying to strengthen its NCAA tournament hopes. Antonio Barton made four 3-pointers and scored 14 points while Jordan McCrae and Jeronne Maymon had 13 apiece. Josh Richardson scored 10.
Maymon also had eight rebounds for the Vols, who outrebounded the Tigers 43-25.
Freshman Tahj Shamsid-Deen had 17 points and made five 3-pointers for Auburn, which has dropped six of its last eight games.
KT Harrell scored 15 and Asauhn Dixon-Tatum added 12 points. Chris Denson, the SEC's No. 2 scorer, finished with a season-low three points in his final game at Auburn Arena.


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It's a strange time for brands. Once-upon-a-time you could plan out your digital strategy by getting a website and maybe even a Flash-powered micro-site just for that product you are pushing.
Or, maybe you could even have a mobile application that would require the user to jump through 15 hoops to see something, well, distinctly underwhelming.
Then things started to change through large consolidated websites, allowing brands to engage with their audiences on a deeper level - social networks. At first it was cool to see a brand on Facebook, then by following your brand you could get access to some exclusive competitions, and because entries were relatively low, you actually had a real chance to win.
Now, things are moving again, your favourite brand has spammed your wall with often banal messages, you no longer have a chance of winning competitions and there are too many followers making you part of the crowd rather than the inside fan. We need to make customers feel they are wanted.
I find digital platforms have provided excellent ways of engagement but often can fatigue users, especially as the digital lifespan is usually quite short - do users want to invest their time in a platform that may not last?
Despite these platforms providing the base for two-way conversations between themselves and their audience, I think there are other ways to engage and excite.
Video games have a huge potential to bridge the engagement gap. Games have become a standard throughout our lives; core computer game fans are no longer sweaty pariahs in society, but are informed, socially aware and have a disposable income.
With the gaming demographic extending its span due to Facebook social games such as Farmville - 20 million monthly active users, 60% female with an average age of 43 - brands have a powerful way of interacting; the rise of casual games as a form of engagement is an opportunity not to be missed.
However, the disconnection between most brands and gaming is vast, especially considering how aligned the platforms can be.
Often brands do not understand what makes a good game, and game developers don't understand what makes a good brand. This is where a convergence between brand agencies and game developers should be key.
For instance, I'm still amazed by the lack of engagement with car brands and racing games. Eons ago, I helped build a simple PC racing game for a well known car maker costing £300k - now that may sound a lot, but after receiving 10 million unique visitors to their site it was a huge win. Not only that, most car makers expect to license their cars to racing titles and often miss out on an extensive audience.
Some brands - for example BMW - understand the opportunity. Over the past couple of years I have seen BMW showcase its products through AAA console racing games; I mean, what could be better than driving a virtual BMW then getting in the real thing.
It also didn't restrict itself to the console; its advergame BMW xDrive Challenge had at its peak 6,000 daily players with a peak of 90,000 a month.
BMW seemingly has a handle on the power of gaming and understand how brand alignment with a rich gaming perspective enhances its brand perception with a core audience. Now to really impact, I would like to see more consolidation, integrating game play deeper into its existing social channels; creating game competitions and broadcast to drive traffic to experiential events.
Now, let's have a look at game building, a different beast to digital production. Firstly make sure you are working with people who know how to build games (games studios), they will also have the contacts with publishers who will help provide visibility for the game, otherwise you are all alone.
Then, identify the correct platform, 90% of the time mobile due to cost of entry. Make sure it is good - a flippant remark I know as there are several factors, but would you play it?
Build in longevity, this can be done by building games that allow you to share easily with friends, provide more random elements (physics based games) which ensure gameplay is not repeated and finally keep gameplay simple.
Identify opportunities to socially seed and do not make in-game branding too in-your-face' - gamers are clever, they have tried hundreds of games and being subtle is the route to success.
Different markets require different games: Asia and the West like different gametypes, they also like different mechanics - for instance, in the US gamers feel it is acceptable to buy a bigger gun (pay to win) whereas in Asia this is not the done thing.
Platform measurement, something still largely underestimated by brands. I have seen clients excited with 5,000 unique visitors on their website for their procured Flash game, when really they should be looking at 250,000 downloads on the app store - this expectation needs to be adjusted. Make sure you build a game where the market is!
Right, maybe something you didn't think of: gaming pays. Any commissioned game can provide a healthy financial return - you may even make the next Angry Birds. Ok, it's expensive to build a quality game,for instance mobile games are having higher and higher production values, the days of one developer and one artist producing a hit are rapidly diminishing (still does happen though).
Now, spending £150-200k on a mobile game would be quite good value for most game publishers, as long as it fits within an eco-system that will be certain to generate income.
In the case for brands, unlike many games you shouldn't charge for download as you want maximum uptake. However, you can create games with social hooks which will promote in-game micro-transactions, this is where as a brand you can recoup your investment and increase the engagement considerably as users spend much more time with a compelling game.
But don't think you have to build a game to engage with the casual gamer, partnerships with established games are powerful, in-game items that can perform a boost to gameplay and that are branded are easy wins.
For instance, let's say a certain running shoe makes you perform slightly faster, gamers will align performance with the brand or product, and sometimes pay for it. Or consider brand placement: when Zynga can guarantee a billion views on a game, why not pay to build a virtual house within CityVille for instance, that gives users rewards.
Consolidation is key, by using gaming elements to power awareness, experiential togenerate conversation and digital (social+web) to bind the content together, this can be the route to a sustained and successful campaign.


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The GM 31x Q gooseneck microphone is available as optional accessory to connect to the microphone unit. Due to the cardioid polar pattern this microphone has a high gain before feedback and provides highest intelligibility of speech. The LED ring displays the ready-to-talk status of the microphone. Inside the microphone there is a filter to eliminate wind an pop noise. The microphone features the innovative Scudio™ technology, making the microphones absolutely insensitive to wireless communication devices such as mobile phones. The microphone is mounted on a 6 mm thick gooseneck and due to its mat black, non-glare surface almost invisible.
beyerdynamic GmbH & Co. KGTheresienstr. 8D-74072 Heilbronn
Phone: +49 (0)7131 - 617-400E-mail


text:
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Furthur wrote:Either get a lighter one, throw harder, or find a disc with more glide.
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Kranitz garners thanks from Maddux
ST. PETERSBURG -- -- Brewers pitching coach Rick Kranitz was honored to hear that his name was part of Greg Maddux's Hall of Fame induction speech on Sunday. Maddux thanked Kranitz for helping him develop a changeup.
"It's nice that he took the time to mention that, because it happened so long ago," Kranitz said. "Every time I've seen him, he would always mention something. It's nice to know you helped somebody along the way."
Both were rookies when they met, Kranitz in his first coaching assignment at Pikeville in the Rookie Appalachian League, and Maddux an 18-year-old who had just been drafted by the Cubs in the second round.
Personality-wise, Maddux was the same prankster he is today, Kranitz said. In terms of pitching, he was much different.
"He threw very hard," Kranitz said. "We didn't use radar guns back then, but it was hard. It was four-seam and a nasty curveball, and he just threw balls by guys -- until he got tired. Then, when he got tired, that's when he would start giving up some hits. But he was always very competitive."
The changeup became a big pitch for Maddux. From 2002 through the end of his career, he threw it more than 23 percent of the time.
Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. This story was not subject to the approval of Major League Baseball or its clubs.


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80 MHz Bandwidth, Dual IF Receiver
Features and Benefits
- JESD204B Subclass 0 or Subclass 1 coded serial digital outputs
- Signal-to-noise ratio (SNR) = 71.9 dBFS at 185 MHz AIN and 250 MSPS with NSR set to 33%
- Spurious-free dynamic range (SFDR) = 88 dBc at 185 MHz AIN and 250 MSPS
- Total power consumption:
707 mW at 250 MSPS
- 1.8 V supply voltages
- Integer 1-to-8 input clock divider
- Sample rates of up to 250 MSPS
- IF sampling frequencies of up to 400 MHz
- Internal analog-to-digital converter (ADC) voltage reference
- See data sheet for additional features
Product Categories
RF & Microwave
Markets & Technology
Product Details
The AD6673 is an 11-bit, 250 MSPS, dual-channel intermediate frequency (IF) receiver specifically designed to support multi-antenna systems in telecommunication applications where high dynamic range performance, low power, and small size are desired.
The device consists of two high performance analog-to-digital converters (ADCs) and noise shaping requantizer (NSR) digital blocks. Each ADC consists of a multistage, differential pipelined architecture with integrated output error correction logic, and each ADC features a wide bandwidth switched capacitor sampling network within the first stage of the differential pipeline. An integrated voltage reference eases design considerations. A duty cycle stabilizer (DCS) compensates for variations in the ADC clock duty cycle, allowing the converters to maintain excellent performance.
Each ADC output is connected internally to an NSR block. The integrated NSR circuitry allows for improved SNR performance in a smaller frequency band within the Nyquist bandwidth. The device supports two different output modes selectable via the SPI. With the NSR feature enabled, the outputs of the ADCs are processed such that the AD6673 supports enhanced SNR performance within a limited portion of the Nyquist bandwidth while maintaining an 11-bit output resolution.
The NSR block can be programmed to provide a bandwidth of either 22% or 33% of the sample clock. For example, with a sample clock rate of 250 MSPS, the AD6673 can achieve up to 76.3 dBFS SNR for a 55 MHz bandwidth in the 22% mode and up to 73.5 dBFS SNR for a 82 MHz bandwidth in the 33% mode.
When the NSR block is disabled, the ADC data is provided directly to the output at a resolution of 11 bits. The AD6673 can achieve up to 65.9 dBFS SNR for the entire Nyquist bandwidth when operated in this mode. This allows the AD6673 to be used in telecommunication applications such as a digital predistortion observation path where wider bandwidths are required.
By default the ADC output data is routed directly to the two external JESD204B serial output lanes. These outputs are at current mode logic (CML) voltage levels. Two modes are supported such that output coded data is either sent through one lane or two (L = 1; F = 4 or L = 2; F = 2). Single lane operation supports converter rates up to 125 MSPS. Synchronization input controls (SYNCINB± and SYSREF±) are provided.
Product Highlights
- The configurable JESD204B output block with an integrated phase-locked loop (PLL) to support up to 5 Gbps per lane with up to two lanes.
- IF receiver includes two, 11-bit, 250 MSPS ADCs with programmable noise shaping requantizer (NSR) function that allows for improved SNR within a reduced bandwidth of 22% or 33% of the sample rate.
- Support for an optional RF clock input to ease system board design.
- Proprietary differential input maintains excellent SNR performance for input frequencies of up to 400 MHz.
- An on-chip integer, 1-to-8 input clock divider and SYNC input allows synchronization of multiple devices.
- Operation from a single 1.8 V power supply.
- Standard serial port interface (SPI) that supports various product features and functions, such as controlling the clock DCS, power-down, test modes, voltage reference mode, overrange fast detection, and serial output configuration.
- Communications
- Diversity radio and smart antenna (MIMO) systems
- Multimode digital receivers (3G)
TD-SCDMA, WiMAX, WCDMA, CDMA2000, GSM, EDGE, LTE
- I/Q demodulation systems
- General-purpose software radios
Comparable Parts Click to see all in Parametric Search
Comparable Parts Click to see all in Parametric Search
Product Lifecycle
This product has been released to the market. The data sheet contains all final specifications and operating conditions. For new designs, ADI recommends utilization of these products.
Product Details
This page contains evaluation board ordering information for evaluating the AD6673.
Features & Benefits
- Full featured evaluation board for the AD6673
- SPI interface for setup and control
- Balun/transformer or amplifier input drive option
- On-board LDO regulator needing a single external 6 V, 2 A dc supply
- VisualAnalog® and SPI controller software interfaces
Product Details
The CVT-ADC-FMC-INTPZB interposer board allows certain Analog Devices' High-Speed ADC Evaluation Boards to be used on certain Xilinx® evaluation boards with a FMC connector. The adapter board uses the High Pin Count (HPC) version of the FMC connector, so it can be used on either LPC or HPC hosts (such as the KC705 or VC707). For a list of verified ADI ADC evaluation boards and Xilinx® evaluation boards, please see AD-ADC-FMC Adapter Board (Wiki page where we will have a table of high speed ADC eval boards and comments if needed).
Virtual Eval - BETA
Virtual Eval is a web application to assist designers in product evaluation of ADCs, DACs, and other ADI products. Using detailed models on Analog's servers, Virtual Eval simulates crucial part performance characteristics within seconds. Configure operating conditions such as input tones and external jitter, as well as device features like gain or digital down-conversion. Performance characteristics include noise, distortion, and resolution, FFTs, timing diagrams, response plots, and more.
IBIS Models
Design Tools
Visual Analog
For designers who are selecting or evaluating high speed ADCs, VisualAnalog™ is a software package that combines a powerful set of simulation and data analysis tools with a user-friendly graphical interface.
JESD204 Serial Interface
The JESD204 and the JESD204B revision data converter serial interface standard was created through the JEDEC...
FPGA Interoperability Reports
Validating ADI Converters Inter-operability with Xilinx FPGA and JESD204B IP
FPGA Interoperability Reports
Altera AN-753 (AD9250 Arria5)
ADI has always placed the highest emphasis on delivering products that meet the maximum levels of quality and reliability. We achieve this by incorporating quality and reliability checks in every scope of product and process design, and in the manufacturing process as well. "Zero defects" for shipped products is always our goal.
The USA list pricing shown is for BUDGETARY USE ONLY, shown in United States dollars (FOB USA per unit for the stated volume), and is subject to change. International prices may differ due to local duties, taxes, fees and exchange rates. For volume-specific price or delivery quotes, please contact your local Analog Devices, Inc. sales office or authorized distributor. Pricing displayed for Evaluation Boards and Kits is based on 1-piece pricing.


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Contact Information
Women & Children's Hospital of Buffalo
First Floor near the 118 Hodge Ave. Entrance
219 Bryant Street
Buffalo, NY 14222
- (716) 878-7776
Main Office
- (716) 878-7401
Correspondence/Release of Information
- (716) 888-3815 Fax
- 8 a.m. - 4 p.m.
- Map & Directions
Health Information Management Department (Medical Records)
The Health Information Management Department provides services to patients, healthcare providers and other authorized requestors, resulting from the management of healthcare data and records generated by patient care services at the Women & Children's Hospital of Buffalo.
Services provided by the Health Information Management Department at WCHOB include provision of an accurate patient record, as supported by:
- Record processing (assembly and analysis)
- Coding, DRG assignment and abstracting
- Registry and other database management services (Birth Registry, Cancer Registry, Tumor Registry, SPARCS data submission, Hospital-based statistical indices)
- Centralized physician transcription services
- Correspondence and release of information
- Record maintenance (storage and retrieval)
The Health Information Management Department is committed to providing accurate, timely and useful health information to meet the needs of its users. The department supports the mission of Kaleida Health through the capture and storage of key clinical data, the conversion of the data into strategic information and the timely communication of that information to authorized requestors.
To request a copy of your medical record, you may download a Release of Information form from the Kaleida Health website, www.kaleidahealth.org, under the "Contact" tab and mail the completed form to:
Women & Children's Hospital of Buffalo
Att: Health Information Management Dept-Correspondence
219 Bryant Street
Buffalo, NY 14222
How to obtain copies of birth certificates
Even though the hospitals of Kaleida Health collect information, complete the original birth certificates, and submit the information to the New York State Department of Health, the birth certificates are maintained by the Department of Vital Statistics in the person's city or town.
All requests for copies of birth certificates must be made to these departments. There may be a small charge for additional copies of birth certificates.
If a child was born at the Women & Children's Hospital of Buffalo contact:
Vital Statistics
City Hall
Buffalo, NY 14202
General Information and Requests: (716) 851-5431
New Births Only: (716) 851-5447
Above all, the department is committed to safeguarding the confidentiality of patient, financial and facility information to protect the privacy rights of our patients.


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MIAMI BEACH, Fla. - BCS fans partied all weekend long in preparation for the BCS National Championship game.
This year two dynasties, University of Alabama and University of Notre Dame, will go head-to-head to claim the title.
Fans from both sides cheered and chanted through the Miami Beach streets. Both are very confident they'll be taking home a win.
But as thousands upon thousands of those die-hard fans anxiously await game day, they are enjoying what South Beach has to offer.
Restaurants are cashing in on the large crowds extending seating onto a closed Ocean Drive, while managers hustle to keep up with booming business.
If you plan on heading out to South Beach, beware that Ocean Drive from 5th to 14th street is closed off to traffic until Monday morning. The street is closed off because the Discover Championship Fan Experience was being held Saturday and Sunday, from 12 p.m. until 8 p.m. along Ocean Drive between 7th and 8th streets.
On Sunday, the party capped off with a concert featuring DJ Irie, Dierks Bentley, and Flo Rida.
The BCS Title Game is Monday night at Sun Life Stadium.
Copyright 2013 by Local10.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Lannan won't be seeking real estate in NY just yet
PORT ST. LUCIE, Fla. -- He may be from Long Island, making him more of a New Yorker than anyone else on the Mets' spring roster. But John Lannan is not about to go searching for a summer home around the city just yet.
"That would be like the ultimate jinx," Lannan said.
A leading candidate for the Mets' fifth-starter job, Lannan recalls being told that he won a similar competition toward the end of Nationals camp in 2012. So Lannan went apartment hunting in Washington, signing a lease the same day the Nats changed their minds and named Ross Detwiler the fifth starter instead.
Lannan's landlord was kind enough to let him out of the lease, but the veteran pitcher now understands what sort of karma can result from such actions. With that in mind, Lannan -- a Long Island native and current Florida resident who hopes to move back to New Jersey in the future -- will not call up any New York City realtors until he has a locker with a nameplate above it in the Citi Field clubhouse.
Lannan will start for the first time this spring on Saturday against the Marlins.
Anthony DiComo is a reporter for MLB.com. Follow him on Twitter @AnthonyDicomo. This story was not subject to the approval of Major League Baseball or its clubs.


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Fenretinide in Healthy Young Women at Genetic and Familial Risk
This study has been terminated.
(very low rate of patient accrual)
European Institute of Oncology
Information provided by (Responsible Party):
European Institute of Oncology
ClinicalTrials.gov Identifier:
First received: November 22, 2011
Last updated: January 21, 2016
Last verified: December 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Show Detailed Description
The purpose of this trial is to assess the effect of fenretinide (4-HPR), a vitamin A derivative, in reducing the incidence of breast cancer in healthy premenopausal women at increased familial/genetic risk for breast cancer
|High-Risk Cancer
|Drug: Fenretinide Other: Placebo
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention
|Official Title:
|Breast Cancer Prevention With Fenretinide in Young Women at Genetic and Familil Risk. A Phase III Randomized Clinical Trial
Resource links provided by NLM:
Genetics Home Reference related topics: breast cancerU.S. FDA Resources
Further study details as provided by European Institute of Oncology:
Primary Outcome Measures:
- Breast cancer incidence [ Time Frame: every 6 months for 15 years ]The aim of the proposed trial is to assess the efficacy of fenretinide, (4 hydroxyphenilretinamide, 4-HPR), a vitamin A derivative, in reducing the incidence of breast cancer (BC) in healthy young premenopausal women at increased familial/genetic risk for BC (i.e. BRCA1 or BRCA2 mutation carriers or subjects at high risk of being carriers). The primary endpoint is the incidence of invasive BC and ductal intraepithelial neoplasia (DIN), histologically diagnosed.
Secondary Outcome Measures:
- Incidence of other non-invasive breast disorders, ovarian cancers and other cancers. [ Time Frame: every 6 months for 15 years ]
Incidence of other non-invasive breast disorders, ovarian cancers and other cancers.
Early intermediate biomarkers of efficacy after 12, 36, and 60 months of treatment. We will also evaluate the percent change in circulating biomarkers of the IGF system, androgens, retinol binding protein (RBP-4), insulin, blood glucose and VEGF, after 12, 36 and 60 months of treatment.
|Study Start Date:
|December 2009
|Estimated Study Completion Date:
|December 2024
|Estimated Primary Completion Date:
|December 2024 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Fenretinide
100mg: 2cps/day for 5 years followed by
Drug: Fenretinide
100mg (2cps/day) for 5 years
Placebo Comparator: Placebo
matched placebo 2 cps/day for 5 years
Other: Placebo
2 cpr/day of matched placebo for 5 years
Show Detailed Description
|Ages Eligible for Study:
|20 Years to 46 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- 20-46 years old women with a known BRCA ½ mutation or with a risk of being a mutation carrier ≥20%.
- Performance status =0
- Willingness to avoid pregnancy during treatment and 12 months after drug cessation
- No clinical and radiological evidence of breast cancer and ovarian disease
- Signed informed consent
Exclusion Criteria:
- History of breast cancer or any other malignancy with the exclusion of CIN and non-melanoma skin cancer
- Child bearing or breast feeding
- Genetic test result (BRCA)=true negative
- Blood test alterations (grade ≥2 based on the NCI Common Toxicity Criteria)
- Previous or concurrent use of SERMs, e.g. tamoxifen (for more than 12 months; if less, a two-months wash-out is required before entering the study)
- Severe psychiatric disorders or inability to comply to the protocol procedures
- Any other factor that, at the investigator's discretion, contraindicates the use of fenretinide
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01479192
Please refer to this study by its ClinicalTrials.gov identifier: NCT01479192
|European Institute of Oncology
|Milan, Italy
Sponsors and Collaborators
European Institute of Oncology
|Study Chair:
|Umberto Veronesi
|European Institute of Oncology
More Information
Keywords provided by European Institute of Oncology:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|European Institute of Oncology
|ClinicalTrials.gov Identifier:
|NCT01479192 History of Changes
|Other Study ID Numbers:
2009-010260-41 ( EudraCT Number )
|Study First Received:
|November 22, 2011
|Last Updated:
|January 21, 2016
Keywords provided by European Institute of Oncology:
ClinicalTrials.gov processed this record on September 21, 2017