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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Senior Health
Inappropriate behavior
My mother in law has been asking my daughter of 6 very personal questions about me and my husband (who does what in the house, who cooks, cleans, where we sleep? ) who do yo like best mummy or daddy? Apparently my daughter feels nanny doesn`t like me much and always speaks highly of her dad. My mother in law has very often waiated for my husband to leave the room before the questions start? Is this a normal thing for a 90 year old to do? My husband is her favourite son and she does worry a lot about himn
Normal or "usual" behavioral interactions for an individual, regardless of age, is somewhat subjective but usually consistent over the years. According to experts, if a person behaves a certain way in younger years, that behavior doesn't usually change that much during the usual or normal aging process, no matter what age.
Wondering if your mother in law has behaved like this in past? Has she asked personal questions of you in the past? Her son? If you and your family concur that this current behavior is not usual or is "outside" the norm for your mother in law but represents a major change, I suggest that she be seen by her primary physician for assessment to ensure that all is well physically and cognitively. There could be underlying conditions that may result in significant behavior changes and need to be assessed.
Evelyn L Fitzwater, DSN, RN
Associate Professor Emerita
Associate Director of the
College of Nursing
University of Cincinnati


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Press release
from the N.C. Wildlife Resources Commision
ASHEVILLE, N.C. (March 14, 2013) — The N.C. Wildlife Resources Commission is planning a litter pick-up and bird-watching activity at the Sandy Mush Game Land beginning at 9 a.m. on March 23.
Volunteers will meet at 9 a.m. in the parking area where Old N.C. 20 crosses Turkey Creek (N35.704637, W082.669082). Staff and volunteers will clean the portion of the game land in Buncombe County about 12 miles north of Asheville along Old N.C. 20 from the Turkey Creek bridge heading west. The Commission will supply bags, gloves and bottled water.
"Bring binoculars, bird guides and notebooks because the group will watch birds and check on kestrel activity near the nest boxes after the litter pick-up ends midday," said Conservation Technician Joe Tomcho. "Prepare to get dirty, but be ready to have some fun bird watching too."
For more information or directions, call Tomcho at 828-682-6718.
About the N.C. Wildlife Resources Commission
Since 1947, the N.C. Wildlife Resources Commission has been dedicated to the conservation and sustainability of the state's fish and wildlife resources through research, scientific management, wise use, and public input. The Commission is the state regulatory agency responsible for the enforcement of fishing, hunting, trapping and boating laws and provides programs and opportunities for wildlife-related educational, recreational and sporting activities. To learn more, visit www.ncwildlife.org.
Get N.C. Wildlife Update — news including season dates, bag limits, legislative updates and more — delivered free to your Inbox from the N.C. Wildlife Resources Commission. Go to www.ncwildlife.org/enews.

subset: commoncrawl


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Stephen Maguire tumbled out of the Dafabet World Championship in an all-too-familiar heartbreaking fashion as Welsh qualifier Ryan Day claimed the Scot's scalp on Sunday.
For the third time in the last four years, and on a night of high drama at the Crucible, former world number two Maguire went out in the first round as he was overturned 10-9.
The 33-year-old Glaswegian had endured a largely disappointing season before coming to Sheffield, but reserved his best performances for the majors, reaching the quarter-finals of the UK Championship and semi-finals of the Masters.
This time, on the most famous stage in snooker, his performance and demeanour were flat until at 8-4 adrift he happened on prime form, firing in breaks of 56, 134, 58, 74 and 91 to force a deciding frame.
World number 20 Day had been one frame away at 9-6 and the 34-year-old held his nerve under the intense pressure of the decider to make 92 and tee up a possible second-round clash with Judd Trump.
A frustrated Maguire said: "I wish I got beaten 10-4 now. I could be in the pub just now. But obviously, I'm going to fight to the death because it's the Worlds.
"I'm actually glad the season's finished. It's been a season from hell for me. I'll forget about this in half an hour."
He added: "When it went to the decider I thought I was favourite. I had a chance in that last frame and couldn't take it and Ryan made a good break there."
Day said: "I enjoyed it all the way to the end. He came back strongly and played three really good frames. In the decider I managed to keep control of the cue ball and my emotions more importantly to finish it off.
"I'm over the moon. I thought it was a tremendous match. I know how tenacious Stephen is and I knew he was going to fight to the death. I was just hoping for a chance in the last frame and I got it."
Ken Doherty had not been beyond the first round since getting to the 2006 last eight, but the 1997 world champion ended his long wait as he struck a blow for snooker's senior citizens.
The Irish crowd favourite battled from 5-3 behind to win 10-5 against Stuart Bingham, punching the air in delight as he crossed the winning line.
As World Snooker chairman Barry Hearn considers handing tour wild cards to veterans Steve Davis, Stephen Hendry and Jimmy White, it was left to 44-year-old Doherty to show it should be a long time before he needs an exemption.
"I'm here to enjoy myself but I'm not here to make up the numbers," Doherty said. "I've had a lot of special memories out there and they come flooding back when you're out there in the heat of the battle.
"Sometimes they can inspire you, so I'm trying to draw on all that great experience.
"It was magnificent, just fantastic. I was starting to get really emotional."
Shaun Murphy, the 2005 world champion, came from 7-5 adrift of fellow English potter Jamie Cope to win 10-9 in another late-night nail-biter.
Cope, who led 5-4 heading into their evening session, had a terrific chance for a 147 maximum break in the 10th frame but blundered on the ninth red and lost the frame to a 75 clearance from Murphy. It did not look to affect him as he pulled clear again, yet Murphy came charging back with further breaks of 68, 52 and 58 to hit the front.
Cope has battled the snooker yips because of a tremor that affects his cueing and recently brought in a sports psychologist to help with the problem.
He said: "I just couldn't control my arm today.
"In the past few weeks I've taken some big steps forward but this was a big step back. I don't know why I felt the way I did."
A relieved Murphy said: " If that's what this tournament has got in store for me, I want to go home. That first round is like a bloodbath. I've lost my fair share of deciders here and it doesn't get any easier.
"I'm just pleased to get over the line.
"They are the type of matches that as players we all watch at home and in hotel rooms. To play in and be a part of it's mentally scarring."
China's big title hope Ding Junhui built a 6-3 lead over English qualifier Michael Wasley.
Sheffield-based Ding made a total clearance of 136 in the seventh frame, setting a benchmark for the tournament's high-break prize.
Hamilton's Jamie Burnett surged 6-3 ahead of Cambridgeshire cueman Joe Perry.


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Eco Friendly Blinds & Shades
- Make your home green
- Save on energy costs with insulation
- Environmentally sustainable natural fibers
- Reduce reliance on petroleum energy
- Renewable and recycled material
Eco friendly blinds and shades are identified as especially "green" based on material content, recycling potential, and green certifications. Materials such as bamboo, reeds, jute, and real wood are sustainably harvested out of natural elements, reducing harm on the environment. Faux wood blinds are made from specially formulated recycled materials that can be recycled again when it's time to redecorate. EcoGreen shades use environmentally responsible fabrics that are PVC-free, 100% Recyclable, and LEED Certification Friendly, so they can be used as eco friendly window treatments in both residential and commercial settings. There are also earth friendly window treatments that provide energy saving features, such as insulating cellular shades.
Comfortex® Woodwinds® Plantation 2 1/2" ShutterBlinds
retail $116.42 $78.00 + an extra 20% off
- Faux Wood Blinds
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customer reviews for eco friendly
"Great Look"
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Comfortex Plantation Shutter Blinds create a neat clean appearance. The 2 1/2" slats are wonderful for a good view. They close tightly and keep the sunlight out.View this product
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I purchased these blinds for a bathroom and I really like them. They are sturdy and great for a high humidly place such as a bathroom. The cloth tapes look very nice with my decor.View this product


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What is Mixcloud? from Mixcloud on Vimeo.
A friend of mine linked to her DJ Set on Twitter and upon clicking I found it hosted on Mixcloud. I'm always making DJ sets with Traktor and Torq but stopped posted them online because there wasn't a legal way. It seems Mixcloud is paying (or attempting to pay) labels. Being 2010 the site has the usual social features where you can follow friends and connect your profile to Twitter and Facebook. I particularily like that you can embed your DJ sets as you can see below:
"Why can't I download ? Mixcloud is a legal platform for on-demand radio shows, Podcasts and DJ mixes which contain copyrighted music. The only licensing option available at present is a streaming format, and Mixcloud is committed to providing a legal option which supports artists and ensures they receive royalties for the shows and mixes which contain music. In addition, the site can keep track of what you (and your friends) listen to, so we can make better recommendations and provide a more personalised site tuned to exactly what you like to hear." – mixcloud.com
Follow me on Mixcloud: mixcloud.com/thingstocome/


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HacMan back with Giants as ambassador
SCOTTSDALE, Ariz. -- Former Giants All-Star and playoff hero Jeffrey Leonard has joined the team's front office as a community ambassador, the club announced Thursday.
Leonard, who played 14 years in the big leagues, including a memorable stint with the Giants from 1981-88, will represent the organization at various in-season and offseason community events in San Francisco, including the Play Ball Lunch and Breast Cancer Awareness Night at AT&T Park on July 2. He will be at the team's camp in Scottsdale through Sunday to attend club events.
Leonard hit .275 with 99 home runs and 435 RBIs in 789 games in his San Francisco career, and his .275 average as a Giant ranks ninth in the San Francisco-era record books while his 115 stolen bases rank seventh. He is best known in the Bay Area, however, for his 1987 season, when he hit .280 with 19 homers, made the National League All-Star team and was named MVP of the NL Championship Series after batting .417 with four homers and five RBIs in the team's loss to St. Louis in seven games.
"We are delighted to have Jeffrey back with the organization," Giants CEO Larry Baer said. "He joins a deep bench of Giants alumni who are involved in all aspects of the team. He truly embodies what it means to be a Giant and I can't think of a better ambassador for our organization. I know our fans will be thrilled to see him around the ballpark on a regular basis."
Doug Miller is a reporter for MLB.com. Follow him on Twitter @DougMillerMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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I don't usually decorate for St. Patrick's day but I saw this felt clover at the dollar store and thought it would look good on a pillow. I just sewed it on and made a pillow. Super easy and cheap!! It only took me 15 minutes to make, and that was with my dealing with some kids during the middle of it :).
Wednesday, February 29, 2012
Whatever Wednesday: St. Patrick's Day Pillow
Posted by Kaysi @ Keeping it Simple at 3:16 AM 12 comments
Labels: home decor, pillow, sewing, St. Patrick
Tuesday, February 28, 2012
Guest bloggers
I'm looking for some people to do a guest post on my blog. I feel like I've been posting a lot about me lately, I need more from YOU! I'm going to start up my feature Friday again. So if you're interested in doing a tutorial guest post for me, just email me at firstname.lastname@example.com. Thanks!!!
Posted by Kaysi @ Keeping it Simple at 5:37 PM 1 comments
Tutorial Tuesday: Spring Wreath
Is anyone else ready for spring? Even though we have a really mild winter here in Utah, I'm so ready for nice weather. To be able to go the park and play outside. My kids are ready for winter to be over with too!! I felt like I needed a nice and bright wreath on my door, so I found the brightest yarn that I had and made this fun wreath.
This is how I made it:
1) I took a wreath and wrapped it with yarn. It was straw wreath, so it's a little bumpy.
Next I made some flowers out of felt let over from my angry birds costumes.
2) I cut out one big circle and then cut a spiral of circles out of it.
3) Then I wrapped it around itself and glued it together.
4) For this flower I cut out several petals.
5) I glued the ends of the petals.
6) I glued them altogether to make a flower.
7) For this flower I cut out a long strip of felt.
8) Then I folded the strip in half and then cut little slits out of it.
9) I wrapped it around itself and glued it together.
10) I glued the flowers onto the wreath.
And just like that I have a bright wreath for spring (and St. Patrick's Day)
Posted by Kaysi @ Keeping it Simple at 2:02 AM 11 comments
Labels: home decor, Spring, tutorial, wreath
Sunday, February 26, 2012
Motivate me Monday #111
Sponsor of the week: Craftvinyl.com
A huge variety of vinyl at super low prices! Plus this Friday, you can get free shipping!
Hi everyone!!!! I can't believe that it's another week! I got spoiled this past week, my husband had Monday off and he took Friday off for my birthday, so it was a three day week! It was awesome and went by so fast! Since Monday was a holiday this week, I didn't have a chance to go through the links, sorry!!! We were busy spending time with the kids and checking out the children's museum in SLC.
Here is the most viewed link last week:
A home remedy to help with headeaches. As I sit here with headache, I'm thinking I might have to try this!!
A home remedy to help with headeaches. As I sit here with headache, I'm thinking I might have to try this!!
I can't wait to see what you did this past week!
Posted by Kaysi @ Keeping it Simple at 8:00 PM 14 comments
Labels: motivate me monday
Saturday, February 25, 2012
A little glimpse
Today is a very special day to me. You know why? Because it's my birthday!!!
The day has only just begun and it's already been a good weekend. Back at my husband's old job, he always got a day off of work for his birthday. I was always so jealous of him, because I would love a day off from my "work" on my birthday. It just wasn't possible at his last job, he's an accountant and worked at a CPA firm. With my birthday being right in the middle of tax season, not only did I not get the day off, but my day was usually super stressful because it was tax season and he worked long hours.
This year was different, now that he has a new job and works in corporate accounting, he can take the day off. Since this year it is on Saturday, I asked him to take Friday off from work. So he did just that. He took care of the kids and I spent the whole day scrapbooking. I'm so far behind and I really needed to do some. He was awesome, he cleaned for me and let me have a day off of my "work". Yay for a good weekend! :)
I hope that you have a great weekend!! Now I'm off to scrapbook so more!
I hope that you have a great weekend!! Now I'm off to scrapbook so more!
Posted by Kaysi @ Keeping it Simple at 10:00 AM 15 comments
Labels: about ME
Friday, February 24, 2012
Soulmates Review
It's the end of February and I'm sooooo ready for spring!! I'm so ready to be able to send my kids out in the back yard without have to bundle them up. I'm especially ready for warm weather so I can wear flip flops again!! I cannot stand shoes. Really, it's not the shoes that I don't like, it's the socks. Socks drive me crazy!! Especially washing them, they always seem to get lost and folding them takes longer than washing them. Anyway, I lost my train of though. Oh yes, flip flops!! It's about that time of year again and I'm so excited to be able to wear these super cute pair from Solemate Sandals!!
They have a ton of super cute "mates" that are interchangeable for their sandals. The best part about them, they have three buttons, so they will not fall off (I've lost some from another type of sandals before.
One pair of sandals with lots of different mates, so much fun!!!
There are several mates to chose from. They even have little girls!!
Go head over to Solemate Sandals and find a pair of flip flops so you can wear them this spring!!
Posted by Kaysi @ Keeping it Simple at 6:03 AM 3 comments
Labels: review
Thursday, February 23, 2012
Tot Thursday: Legos
We are HUGE fans of Legos at our house. There isn't a day that my boys don't play with them. They just love them. Because they love them soooo much, it seems like I am always picking up Legos. Is it like that at your house? I spend at least 30 minutes a day just picking up Legos!! And still end up stepping on them or finding more in a different room. One day I went over to a friend's house and she had come up with a great solution, put the Legos on a blanket!
So I did just that, I put the Legos on a queen size sheet and let them play on that.
And when it's time to clean up, I just picked up the blanket and put the whole thing in the container.
I'm sure I'll still find Legos here and there but at least I won't be spending as much time putting them away.
Posted by Kaysi @ Keeping it Simple at 2:42 AM 7 comments
Labels: boys, kids craft, toys
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Here's the current setup. I always tend to have a few extras in the bag with me that I'm trying out, but here's what's really 'in the bag!'
2 westside swords in tournament plastic
1 ESP nuke
1 champion tern
1 star roadrunner
1 champion glow gazelle
2 star San Marino rocs
1 champion roc 3
1 prodigy M1
1 champion panther
1 SSS wizard
1 RFF wizard
1 medium vibram ridge - mostly for the just out of jump-putt range.. But I'm thinking of expanding it's use..
I also keep kind of switching between a mako 3 and the new atlas.
Those 'extras' I mentioned:
2 blizzard champion bosses - one 155 one 162 I think
1 zombee
1 opto striker - I used to throw this a lot but now it's more of an ornament..
1 gold line trident - got it for those strong headwinds, but have hardly thrown it
And the newest addition I haven't even gotten to throw yet, a new MikeC mvp axis! I've never thrown MVP, but I'm pumped to try it out.
That's it.. All wrapped up in a Fade tournament bag (with the ever-essential Roc patch on the side ) -- thoughts??


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Hello all,
I hope someone can help me with the meaning of the word "Diṭṭhiñca" in this verse from the Metta Sutta:
152. Diṭṭhiñca anupagamma sīlavā dassanena sampanno
Kāmesu vineyya gedhaṃ nahi jātu gabbhaseyyaṃ punaretīti.
I'm wondering if it could mean Ditthin (adj. -- n.) one who has a view, or theory, a follower of such & such a doctrine Ud 67 (evaŋ˚+evaŋ vādin) rather than simply meaning Wrong View?


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Considering that free agency was supposed to be a dud this year, things got interesting in a hurry on Friday, starting with Daniel Alfredsson leaving Ottawa, after spending his entire career in Canada's capital, to join the Senators' new division rivals, the Detroit Red Wings. By the end of the day, more than 50 unrestricted free agents had signed contracts either with new teams or the ones they previously played for, and there were restricted free agents agreeing to extensions, and trades as well.
Who did the most to help themselves on Friday? Here are the biggest winners, as much as you could say that about anybody…
NHL FREE AGENTS: Sporting News' list of 25 | Bruins make Seguin mistake
BIG NEWS: Alfie a Wing | Ryan to Sens | Horton to CBJ | Leafs mess up
Edmonton Oilers
It's not a star-studded crop of free agents, but the Oilers weren't shopping for stars because their stars are homegrown and already in place in Jordan Eberle, Taylor Hall, Ryan Nugent-Hopkins and Nail Yakupov up front, and Justin Schultz on the blue line.
Edmonton's biggest expenditures were on veteran defenseman Andrew Ference—four years, $13 million to provide leadership and stability on the back end—and defensive center Boyd Gordon—three years, $9 million to win big faceoffs and take the tough shifts so that those talented youngsters' goals stand up. Then there were deals with backup goalie Jason Labarbera, and depth forwards Will Acton, Ryan Hamilton and Jesse Joensuu.
The Oilers have not been to the playoffs since 2006, and part of Ference's allure was that he was part of the Bruins' 2011 championship team, as well as the group that went to the Stanley Cup finals last month. Dallas Eakins, who coached Hamilton with the Toronto Marlies in the AHL, will be the Oilers' fourth coach in five seasons.
"The situation isn't entirely different from when I go back to when we first started turning this thing around in Boston," Ference said. "Talking to Dallas, and hearing his approach to the game, it really meshed with mine. That experience and that success is earned, through hard work, honest work, and accountability. All those things that are really easy to talk about, but a lot harder to do. I think he really is committed to having those things in the organization. That's important to me, to be around people that aren't happy with just being OK."
Ference is 34, so a quick progression in Edmonton, where he'll also be asked to set an example for this year's first-round pick Darnell Nurse, is important if he hopes to win a Cup with his hometown team. The addition of Gordon, 29, helps to ease the pain of Thursday's trade that sent Oilers captain Shawn Horcoff to Dallas—Gordon is five years younger, better suited for the role he'll be asked to play, and $2.5 million cheaper annually.
Adding Labarbera as a backup is a solid vote of confidence in Devan Dubnyk, as the Oilers brought in a true backup rather than someone who might challenge for the starter's role. That's a gamble, but one worth taking.
Ottawa Senators
Get past the drama of losing Alfredsson, whose departure for a division rival definitely stings, and recognize that the Senators ended Friday a better team than they began it with the additions of Bobby Ryan in a trade with the Anaheim Ducks and Clarke MacArthur on a very reasonable, two-year, $6.5 million contract to come across Ontario from the Toronto Maple Leafs.
General manager Bryan Murray may have had the hardest time getting past the drama of anyone, as he arrived at his press conference with a written timeline explaining Alfredsson's departure, and delivered one of the more detailed explanations of failed negotiations that you'll ever see. Why Murray did that, emphasizing Alfredsson's exit instead of Ryan's arrival, is anyone's guess, but that's what happened. Anyway, Ryan was excited to finally be done with years of trade rumors in Anaheim.
"Ottawa….I'm coming in hot," the winger tweeted.
Ryan has been a 30-goal scorer each of the last four full NHL seasons, and had 11 goals in this past shortened campaign. He is 26 years old and probably fits better on the Senators at this point than the 40-year-old Alfredsson. If things worked out differently, the Senators could have had both players, but as it is, the Senators go into next season with strong goaltending from Craig Anderson, a defense corps led by healthy-again 2012 Norris Trophy winner Erik Karlsson, and Ryan along with healthy-again Jason Spezza as the offensive 1-2 punch.
That's not to mention MacArthur, a 20-goal scorer each of the two seasons before the lockout, and before he was held to 14:55 per game by Randy Carlyle during an eight-goal campaign over 40 games. Even at that 16-goal pace for a full season, MacArthur would be delivering the kind of secondary scoring he has been signed for, and at $3.25 million per year, he'd be doing it for decent value.
Ottawa still has a solid amount of young talent, so while giving up Jakob Silfverberg, 2011 first-round pick Stefan Noesen, and next year's first-rounder is a tough pill to swallow, the Senators could afford to send them away for Ryan.
New York Islanders
The strategy employed by Garth Snow is a fascinating one, as the Islanders' general manager gave out the richest one-year contract of the day (until Jarome Iginla's), a $2 million pact to add Pierre-Marc Bouchard from the Minnesota Wild, whom he scored 20 goals in 2006-07 and had only 20 points (eight goals, 12 assists this season).
If that sounds familiar, that's because last year, Snow signed Brad Boyes to a one-year, $1 million contract, hoping that the former 43-goal scorer would rediscover some of his offensive touch on a line with Matt Moulson and John Tavares. Boyes had 35 points in 48 games, his best showing on a points-per-game basis since 2008-09 with St. Louis.
It's not just about taking a flier on a player and hoping that he rediscovers himself, though. Snow went against the grain further on Friday by re-signing restricted free agent defenseman Travis Hamonic to a seven-year deal—the opposite of what the Montreal Canadiens and New York Rangers did last year when they signed P.K. Subban and Michael Del Zotto, respectively, to two-year contracts that will eventually see them get huge raises. Hamonic will be slightly overpaid for his age, but when he's in his prime and making less than $4 million a year, he figures to be a steal, while Subban may need to back up a dump truck to his house to receive his salary.
Getting 27-year-old Peter Regin for one year and $750,000 was a fine move to replace 34-year-old Keith Aucoin, who had a nice season in the Islanders' bottom six, but went to St. Louis as a free agent. The one confusing move was re-signing Evgeni Nabokov to play goal for another season, but if the Islanders are paving the way for 23-year-old Kevin Poulin to play more, it makes more sense.
Honorable mention
The Buffalo Sabres and Washington Capitals did absolutely nothing on Friday. On a day when the "winners" were teams who purchased moderate upgrades at steep costs, it was a good idea to stay on the sidelines and go bargain hunting later. … The Red Wings did well to surprise everyone and get Alfredsson, and Stephen Weiss is a solid signing as a second-line center. … The Nashville Predators went a little too long on their contracts for Eric Nystrom and Matt Hendricks at four years apiece, but together with Viktor Stalberg and Matt Cullen, they provide a nice boost to the forward corps. … The Jets' only move was trading a second-round pick to the Wild for Setoguchi, who's capable 20 goals on a top-six wing.


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The Globe Off Liverpool Road Buckley Flintshire CH7 3LY View with Google Maps
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Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST)
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2006 by Maisonneuve-Rosemont Hospital.
Recruitment status was: Recruiting
Recruitment status was: Recruiting
Maisonneuve-Rosemont Hospital
Hippocrate Research & Development
Information provided by:
Maisonneuve-Rosemont Hospital
ClinicalTrials.gov Identifier:
First received: February 9, 2006
Last updated: April 6, 2006
Last verified: April 2006
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The aim of this study is to demonstrate that the use of Gleevec in initially non-resectable gastrointestinal stromal tumors can lead to allow complete resection in 20% of cases.
|Gastrointestinal Stromal Tumors
|Drug: Imatinib mesylate
|Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase II Study on Preoperative Administration of Gleevec in Patients With Initially Non-Resectable Gastrointestinal Stromal Tumor
Resource links provided by NLM:
Genetics Home Reference related topics: gastrointestinal stromal tumor
Drug Information available for: Imatinib Imatinib mesylateU.S. FDA Resources
Further study details as provided by Maisonneuve-Rosemont Hospital:
Primary Outcome Measures:
- Patient response rate according to RECIST criteria
Secondary Outcome Measures:
- Clinical response to treatment
- Radiological response to treatment
- Pathological response to treatment
- Compare clinical with pathological response
- Evaluate the impact of Gleevec on surgical morbidity
- Evaluate disease-free survival
- Evaluate overall survival
- Evaluate whether the response rate can predict survival
|Estimated Enrollment:
|Study Start Date:
|August 2005
Gastrointestinal stromal tumor (GIST) is a specific, immunohistochemically KIT+ mesenchymal neoplasm of the gastrointestinal tract. The identification of KIT+ tumor has become more important after introduction of target treatment with KIT tyrosine kinase inhibitor Imatinib mesylate (Gleevec). Despite this progress, GIST patients presenting a tumor larger than 5 cm have a 10 year survival between 10% and 30%. Indeed, the risk of microscopic spreading of the tumor during surgery is very high since intra-abdominal organs are in close relation to each others. To improve survival, it seemed logical to use preoperative Gleevec to reduce tumor size and improve efficacy of the surgical procedure.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
GIST patient considered initially non-resectable as defined by one of the following:
- when the surgical team considers that the risk of incomplete resection (R1 or R2) of a GIST is higher than 20%
- when the resection of a GIST necessitates a highly morbid procedure
- when a GIST is attached to 3 or more major intra-abdominal structures or to a major intra-abdominal blood vessel
- when GIST is considered at very high risk of recurrence. This is the case when it is a recurrence or when the tumor is in very close contact with a structure that cannot be resected by surgery or when the patient has metastasis.
- Outpatient is 18 years old or more
- ECOG performance status 0, 1 or 2
- Immunohistochemical confirmation of KIT overexpression must exist at the study entry
- Measurable disease on CT-Scan or MRI (ultrasound and/or operative finding are not acceptable) and response to RECIST criteria
- Have a life expectancy of at least 6 months
- Be willing and able to comply with the protocol (and surgery if required) for the duration of the study
- Give written informed consent prior to study-specific screening procedure, with the understanding that the patient has the right to withdraw from the study at any time without prejudice
Exclusion Criteria:
- received Imatinib in the past
- received a full course of radiotherapy within 3 months of inclusion in the study. A short course of radiotherapy to control bleeding is allowed.
- received systemic chemotherapy within 4 weeks of inclusion in the study
- received steroids for less than 4 weeks of inclusion in the study
- pregnant or lactating women
- women of childbearing potential with either a positive or no pregnancy test at baseline. Postmenopausal women must have been amenorrheic for at least 12 months to be considered of non-childbearing potential.
- sexually active males or females (of childbearing potential) unwilling to practice contraception during the study
- history of other malignancy within the past 5 years, except cured basal cell carcinoma of skin and cured carcinoma in-situ of uterine cervix
- clinical or other evidence of CNS metastases
- myocardial infarction within the last 3 months
- any medical condition that contraindicates potential surgery
- lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome or inability to take oral medication
- any serious uncontrolled concomitant disease
any of the following laboratory values:
- absolute neutrophil count < 1.5 E+09/L
- platelet count < 80000 E+09/L
- AST or ALT higher than 2 X normal
- major surgery within 4 weeks prior to start of study treatment, or lack of complete recovery from effects of major surgery
- patients with known or suspected hypersensitivity to one of the Gleevec components.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00290485
Please refer to this study by its ClinicalTrials.gov identifier: NCT00290485
|Contact: Pierre Dubé, MD
|(514) 252-3822
|Canada, Quebec
|Maisonneuve-Rosemont Hospital
|Montreal, Quebec, Canada, h1t 2m4
|Contact: Pierre Dubé, MD (514) 252-3822 firstname.lastname@example.com
|Principal Investigator: Pierre Dubé, MD
Sponsors and Collaborators
Maisonneuve-Rosemont Hospital
Hippocrate Research & Development
|Study Chair:
|Pierre Dubé, MD
|Maisonneuve-Rosemont Hospital
More Information
Keywords provided by Maisonneuve-Rosemont Hospital:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Kitamura Y, Hirota S, Nishida T. Gastrointestinal stromal tumors (GIST): a model for molecule-based diagnosis and treatment of solid tumors. Cancer Sci. 2003 Apr;94(4):315-20. Review. Erratum in: Cancer Sci. 2003 Oct;94(10):930.
Judson I. Gastrointestinal stromal tumours (GIST): biology and treatment. Ann Oncol. 2002;13 Suppl 4:287-9. Review.
Greenson JK. Gastrointestinal stromal tumors and other mesenchymal lesions of the gut. Mod Pathol. 2003 Apr;16(4):366-75. Review.
Bono P, Krause A, von Mehren M, Heinrich MC, Blanke CD, Dimitrijevic S, Demetri GD, Joensuu H. Serum KIT and KIT ligand levels in patients with gastrointestinal stromal tumors treated with imatinib. Blood. 2004 Apr 15;103(8):2929-35. Epub 2004 Jan 8.
Schirru A, Cavaliere D, Cosce U, Scarimbolo M, Griseri G, Caristo I, Bianchi M, Ingravaglieri E, Aiello D, Venturino E. [Surgical treatment of gastrointestinal stromal tumors: personal cases]. Tumori. 2003 Jul-Aug;89(4 Suppl):141-2. Review. Italian.
Liberati G, Lucchetta MC, Petraccia L, Nocchi S, Rosentzwig R, De Matteis A, Grassi M. [Meta-analytical study of gastrointestinal stromal tumors (GIST)]. Clin Ter. 2003 Mar-Apr;154(2):85-91. Italian.
Kanda T, Ohashi M, Makino S, Kaneko K, Matsuki A, Nakagawa S, Hatakeyama K. A successful case of oral molecularly targeted therapy with imatinib for peritoneal metastasis of a gastrointestinal stromal tumor. Int J Clin Oncol. 2003 Jun;8(3):180-3.
Miettinen M, Lasota J. Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol. 2003;54(1):3-24. Review.
DeMatteo RP. The GIST of targeted cancer therapy: a tumor (gastrointestinal stromal tumor), a mutated gene (c-kit), and a molecular inhibitor (STI571). Ann Surg Oncol. 2002 Nov;9(9):831-9. Review.
Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA, Demetri GD. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene. 2001 Aug 16;20(36):5054-8.
Blanke CD, Eisenberg BL, Heinrich MC. Gastrointestinal stromal tumors. Curr Treat Options Oncol. 2001 Dec;2(6):485-91. Review.
Yan H, Marchettini P, Acherman YI, Gething SA, Brun E, Sugarbaker PH. Prognostic assessment of gastrointestinal stromal tumor. Am J Clin Oncol. 2003 Jun;26(3):221-8.
Noguchi T, Sato T, Takeno S, Uchida Y, Kashima K, Yokoyama S, Müller W. Biological analysis of gastrointestinal stromal tumors. Oncol Rep. 2002 Nov-Dec;9(6):1277-82.
Kovac D, Petrovecki M, Jasic M, Dobi-Babic R, Ivanis N, Rubinic M, Krizanac S, Jonjic N, Rizzardi C, Melato M. Prognostic factors of gastrointestinal stromal tumors. Anticancer Res. 2002 May-Jun;22(3):1913-7.
Connolly EM, Gaffney E, Reynolds JV. Gastrointestinal stromal tumours. Br J Surg. 2003 Oct;90(10):1178-86. Review.
Crosby JA, Catton CN, Davis A, Couture J, O'Sullivan B, Kandel R, Swallow CJ. Malignant gastrointestinal stromal tumors of the small intestine: a review of 50 cases from a prospective database. Ann Surg Oncol. 2001 Jan-Feb;8(1):50-9.
Joensuu H. Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec). Med Klin (Munich). 2002 Jan 15;97 Suppl 1:28-30.
Rajput A, Kraybill WG. Clinical trials and soft tissue sarcomas. Surg Oncol Clin N Am. 2003 Apr;12(2):485-97. Review.
Patel SR. Systemic therapy for advanced soft-tissue sarcomas. Curr Oncol Rep. 2002 Jul;4(4):299-304.
Eisenberg BL. Imatinib mesylate: a molecularly targeted therapy for gastrointestinal stromal tumors. Oncology (Williston Park). 2003 Nov;17(11):1615-20; discussion 1620, 1623, 1626 passim. Review.
Rossi CR, Mocellin S, Mencarelli R, Foletto M, Pilati P, Nitti D, Lise M. Gastrointestinal stromal tumors: from a surgical to a molecular approach. Int J Cancer. 2003 Nov 1;107(2):171-6. Review.
Frolov A, Chahwan S, Ochs M, Arnoletti JP, Pan ZZ, Favorova O, Fletcher J, von Mehren M, Eisenberg B, Godwin AK. Response markers and the molecular mechanisms of action of Gleevec in gastrointestinal stromal tumors. Mol Cancer Ther. 2003 Aug;2(8):699-709.
Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002 Aug 15;347(7):472-80.
Bümming P, Andersson J, Meis-Kindblom JM, Klingenstierna H, Engström K, Stierner U, Wängberg B, Jansson S, Ahlman H, Kindblom LG, Nilsson B. Neoadjuvant, adjuvant and palliative treatment of gastrointestinal stromal tumours (GIST) with imatinib: a centre-based study of 17 patients. Br J Cancer. 2003 Aug 4;89(3):460-4.
|ClinicalTrials.gov Identifier:
|NCT00290485 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|February 9, 2006
|Last Updated:
|April 6, 2006
Keywords provided by Maisonneuve-Rosemont Hospital:
non-resectable tumor
high-risk tumor
Response Evaluation Criteria in Solid Tumors (RECIST)
Imatinib mesylate
Additional relevant MeSH terms:
Gastrointestinal Stromal Tumors
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Imatinib Mesylate
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017


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The vice chairwoman of the Florida Senate Gaming Committee, Sen. Maria Sachs, called for greater scrutiny of the Florida Lottery after a Palm Beach Post investigation revealed some people are winning big prizes against enormous odds.
Sachs, D-Delray Beach, has been an advocate of folding the lottery into a state gaming commission, which would be overseen by legislators and include all forms of gambling in the state. She said The Post's investigation further emphasized that need.
"What your investigation has shown is that we need greater oversight," Sachs said.
The Post's six-month investigation revealed that roughly 200 people were defying lottery odds over the last decade to cash in tens or hundreds of winning tickets worth $600 or more.
Mathematicians calculated that nine of the 10 most prolific winners would have lost up to $2 million trying to win so many times.
One man won $719,000 at 69 stores from North Lauderdale to Vero Beach in a six-year span.
In other states, such winning patterns have been found to be associated with criminal activity. Frequent winners in other states were found to have been store clerks stealing tickets from unsuspecting customers, "ticket cashers" who helped lottery winners avoid back taxes or child support and criminals using the lottery to launder money.
Gov. Rick Scott, whose office oversees the lottery and appoints the lottery secretary, said Wednesday, "I know the secretary of the lottery takes everything seriously and wants to make sure it's done properly and with transparency and we're going to make sure there is no fraud."
His office added: "Working with the Florida Lottery, we will continue to increase transparency and hold criminals accountable to protect Florida taxpayers from fraudulent activity."
Lottery Secretary Cynthia O'Connell told The Post before the story ran that the incredible rate of winning could simply be luck. A lottery official said Wednesday the lottery would respond to the story but couldn't predict a time frame.
Sachs said that retailers should have greater scrutiny, also. The Post found six of the top 10 prolific winners were store clerks or owners.
Currently, store clerks and employees can play the lottery without restriction. They can even play from behind the counter if the store allows it.
Some North American lotteries don't permit clerks and owners to play at their own stores.
"They can't be checking the tickets to see if anybody won. They can't be playing," Sachs said. "Your article, and previous articles, have shown that other states do it better."
Rep. Mark Pafford, D-West Palm Beach, said that relationship creates a "perception issue."
"You shouldn't have the hand in the till. That's extremely awkward," he said.
The Post found that some lotteries place restrictions on its retailers. Ontario, one of the largest lotteries in North America, doesn't allow clerks and owners to play at their own stores.
California asks winners if they own or work at a store that sells lottery tickets. Florida doesn't.
The Senate and House gaming committees are considering creation of a gaming commission that would oversee parimutuels and other forms of gambling. But Sachs wants the commission to also oversee the state's $5 billion lottery.
Up to seven people would serve on the commission. They'd be appointed by the governor and overseen by legislators.
"Any time you have a big pot of money and you have so many outlets where people are spending money to get money, you've got to have a lot of oversight," Sachs said.
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And when it happens on your watch, would you be saying it still needs greater scrutiny Sen. Sachs? Then maybe it would be time for big brother
to step in then? Do all these democratic lawmakers see life as smoke and mirrors? As long as nothing is being done illegally, why would you think they needed more scrutiny? I wonder if the same argument can bve said about your voters Sen. Sachs?
She needs to pay attention to things at hand, instead of trying to gain her 15 minutes of fame.
" You can not control the Wind, but you can direct the Sail "
So how did Florida not have a state gaming commission? Or at least a state lottery commission?
State Committees seem to be short lived, as memebrs come and go, very often as the result of newly elected representatives.
This article raises alot of good points.
Good question G. As always " Store Clerks" are associated with Criminal behavior, along with other parasites hell- bent on screwing the playing public. .
I also demand it for california and new york too.
"The Post found six of the top 10 prolific winners were store clerks or owners."
There's your smoking gun. Think about how many tickets pass through their hands every day. A couple clerks who play, sure, but 6 of the top 10 winners?
If the chances of winning the jackpot are so slim, why play when the jackpot is so small? Your chances never change, but the potential payoff does. If a crystal ball showed you the future of the rest of your life, and in that future you will never win a jackpot, would you still play?
2017: 0% (0 tickets)P&L % = Total Win($)/Total Wager($) - 1
Picker..California lottery Commission has its own " Lottery Cops"- they arrest vendor's and pull out their equipment if they play fast & loose with the rules. The Host of " To catch a Predator" ( Chris Hanson ) did a ride along with some of the enforcers out here to nail some vendors who had crossed over to the dark side. The lottery out here does not mess around with crooked Vendors, its jail time. They did & still do " sting operations" where they will have the Ca-lottery make a $500.00 scratch off ticket, have one of their young employees present it to the vendor and say " l don't know how much l have won, could you scan it for me"..that vendor BETTER say $500.00 One Indian vendor told the person " you won $50.00"- in came the enforcers w/ camera's & got their a$$ nailed for fraud. l would not go so far as to say they all over the place- but they out there.
Dear Setator Snatch:
All a Psyko can say is:
U DO UR THANG and Psyko will DO my THANG>>>>>>>>>>>>>>>22222222!!!
When I'm N FL>YES>play D lottery N>UR state as much as possible when dare!!!
Take my WIN'$ N>UR state>>take my losse'$$$$$$$<<<222222222222222222!!!
Like D>>>>>>>>YES>>2>D "FLORDIA" lottery$$$$>>>seem 2 "BREAK" even!!!!
I agree owners should,not play at their own store. An workers should not play were they work. I know you heard the story of willis willis.
Don't know if this is related to pressure to clean things up: FLORIDA LOTTERY ANNOUNCES SUSPENSION OF THREE BROWARD COUNTY RETAILERS TALLAHASSEE -Today the Florida Lottery announced it has suspended the sale of its products at three Pompano Beach retailers after an on-going investigation determined fraudulent activity may have occurred involving the sale of lottery tickets. The Lottery has suspended sales at the following locations: Akel Market, 502 NW 6th St, Pompano Beach Georgia Market, 1404 NW 6th Avenue, Pompano Beach Kwik Stop Food Store, 617 Hammondville Road, Pompano Beach A Lottery law enforcement agent assisted by the Broward County Sheriff's Office removed all lottery equipment, tickets and other property from each store. The contract suspension of all three retailers is temporary while the Florida Lottery continues its investigation. If the investigation concludes that a crime has taken place, the Florida Lottery would terminate the retailer's contract and owners or employees of the stores could face criminal charges. "The Florida Lottery will not tolerate fraudulent activity by our players or retailers. The integrity of the Florida Lottery is our top priority," said Florida Lottery Secretary Cynthia O'Connell. "This action is part of our on-going effort to heighten awareness of what we do as an organization to combat illegal activity." Source: Press Release on Florida Lottery website dated WEDNESDAY, APRIL 2, 2014
"The Post's six-month investigation revealed that roughly 200 people were defying lottery odds over the last decade to cash in tens or hundreds of winning tickets worth $600 or more."
Or the obvious that 200 people are buying and cashing tickets worth $600 or more from the real winners at a reduced cost. The only question should be "is it legal to buy a winning lottery or any ticket from another player?"
"In other states, such winning patterns have been found to be associated with criminal activity. Frequent winners in other states were found to have been store clerks stealing tickets from unsuspecting customers"
This is probably true in every state with a lottery and more likely to happen to players who have no clue how much their ticket is worth. I don't know how a state lottery can make it any more plain when they tell players to sign the back of the tickets before cashing.
To eliminate any possibility of criminal activities, will all Florida player have to prove they actually bought their winning ticket before they can collect?
What about scratch-off and other tickets given as gifts or stocking suffers?
Don't waste your time on pickoneforme. Dude is tin foil afficiando. He's complainng about poweball and MM which are a nationwide games.
The lottery was created as a revenue source for the government.
It feels great to see lottery players demanding changes from the lottery. Are you still playing the lottery?
Sell all lottery tickets through the Internet.
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Nicki Minaj, The Harajuku Barbie
my name is kevin bobby; and i'm your favorite.
big dreams, good music, badd bitches, & expensive taste. i love being loud, witty & outrageous. always one to speak out & never one to stand in line. a small town boy with big city dreams, addicted to the spotlight. can you really blame me? always confident, always over-the-top, but still very humble and friendly. i love love love people, so don't be surprised if i talk your little head off! i met nicki minaj on 3/23/11, my moment 4 life :)
Thu, Mar 31, 2011 at 3:33 AM
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TALLAHASSEE — Following an investigation by Attorney General Pam Bondi's Medicaid Fraud Control Unit, three Levy County residents were arrested by the Levy County Sheriff's Office and the Chiefland Police Department.
Laurie Meeks and Stephanie Tindall are accused of billing the Medicaid program for nearly $80,000 for services never rendered, and Barbara Gamble for billing more than $3,500 for services never rendered.
The following cases were disposed of by Levy County criminal court. Nolle pros means the charge will not be prosecuted.
• Eleuterio Rodriguez-Najera, soliciting business for workers compensation, nolle; fraud by using ID of another person, 24 months probation. Must pay probation cost, $1990.08 restitution.
The Levy County Sheriff's Office reports the following arrests:
The Levy County Sheriff's Office is saddened to announce the loss of our Matron and Cook. Johnnie Mae Jackson. The woman known as "Mama" to all at the Sheriff's Office and jail went home to be with her Lord on Saturday, Jan. 18. She went peacefully while being surrounded by friends and family.
The following cases were disposed of by Levy County criminal court in the month of November. Nolle pros means the charge will not be prosecuted.
Chiefland Police Sgt. Alton Horne, center, was presented with a plaque and a photo of his partner K9 Officer Delta, who died last year, but Levy County Sheriff's Office Cpl. Pete Barnes and members of the sheriff's office K9 team.
The Chiefland Police Department recently donated and wrapped gifts for 40 boys and girls and expressed making next year's donation even bigger.
From Left, Sgt. Macy, CES Principal Angel Thomas, Chief Robert Douglas, and Lt. Jay Bolton.
The Levy County Sheriff's Office reports the following arrests from Jan. 6-13:
Three of Williston's four public schools were in secured campus mode Monday after a fatal stabbing in Alachua County.
Copyright © 2017
The Chiefland Citizen is your source for local news, sports, events, and information in Levy County and Chiefland Florida, and the surrounding area.


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The Lighthouse Word Church Children's Ministry is hosting a Kids Celebration Summer, celebrating who we are in Christ through art, music and dance, each Sunday morning at 10:30 a.m., during the summer months.
We are starting the program with a Kick Off Sunday on June 10th from 10:30 a.m. to 12:30 p.m., with snow cones, cotton candy, popcorn, two bounce houses, celebration train rides, festival games, helium balloons, face painting and music, along with Faith Dog and other character appearances. For more information call 493-1554.
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text: Resources Mayo Clinic products and servicesBook: Mayo Clinic Guide to Stress-Free LivingMayo Clinic StoreNewsletter: Mayo Clinic Health LetterMayo Clinic researchMayo Clinic Cancer CenterMayo Clinic supportGive today to find cancer cures for tomorrowWebsitesCancerCare: Skin cancerNewsletter: Mayo Clinic Health Letter — Online EditionRequest an Appointment at Mayo Clinic Multimedia Aug. 08, 2017 Share on: FacebookTwitter References Niederhuber JE, et al., eds. Nonmelanoma skin cancers. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Aug. 5, 2015. Merkel cell carcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Aug. 5, 2015. Merkel cell carcinoma treatment (PDQ). National Cancer Institute. http://www.cancer.gov/types/skin/patient/merkel-cell-treatment-pdq#section/all. Accessed Sept. 3, 2015. Prevent skin cancer. American Academy of Dermatology. http://www.aad.org/spot-skin-cancer/learn-about-skin-cancer/prevent-skin-cancer. Accessed Sept. 3, 2015. Tai, P. Pathogenesis, clinical features, and diagnosis of Merkel cell (neuroendocrine) carcinoma. http://www.uptodate.com/home. Accessed Sept. 5, 2015. Church CD, et al. How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions and a new mouse model. Journal of Investigative Dermatology. 2015;135:1222. RelatedChest X-raysSentinel node biopsyCT scan Merkel cell carcinomaOverviewSymptoms & causesDiagnosis & treatmentDiagnosisTreatmentDepartments & specialtiesClinical trialsPreparing for your appointmentSelf-managementMore aboutIn-DepthExpert BlogMultimediaResources Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The Last Diet You'll Ever Need4 Simple Steps to a Joy-Filled LifePain Management Strategies from Mayo ClinicStop Osteoporosis in its TracksProtect and Preserve Your Vision Diagnosis & treatmentRequest an AppointmentDiagnosisTreatmentDepartments & specialtiesClinical trialsPreparing for your appointment CON-20155334 Patient Care & Health Information Diseases & Conditions Merkel cell carcinoma


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Summary and Background
On Monday, July 28, Senate Majority Leader Reid filed a cloture motion on the motion to proceed to S.2035, the Free Flow of Information Act of 2007 (also known as the "federal media shield" or "qualified journalists' privilege"), a bill to protect journalists from being compelled to disclose their confidential sources unless a federal court determines by a "preponderance of the evidence" that all reasonable alternative sources have been exhausted; the source is essential; and that non-disclosure would be contrary to the public interest, using a balancing test that takes into account the public interest in a free press.
S.2035 was originally sponsored by Senator Specter, Ranking Member of the Senate Judiciary Committee, along with Senators Schumer and Lugar. The bill was reported out of the Senate Judiciary Committee on October 22, 2007. In recent weeks, in an effort to compromise with Administration officials, Senators Specter, Schumer, and Lugar have made adjustments to the committee-passed bill, and a substitute amendment will be offered when the bill is considered on the floor.
The substitute amendment would provide the following exceptions to this qualified privilege: the journalist is an eyewitness to or has engaged in a crime; or information is needed to prevent death, kidnapping, substantial bodily harm, sexual abuse of a minor, or incapacitation or destruction of critical infrastructure. The amendment would also provide that a federal court can compel a journalist to reveal a confidential source if the court determines by a "preponderance of the evidence" that the information would assist in stopping or preventing significant and articulable harm to national security, or relates to a leak of classified information that has or will cause such harm, and that the harm outweighs the public interest in having the information reported.
The high-profile arrests of journalists for refusal to disclose their sources, as well as investigations by the media into Administration wrong-doings, have drawn attention to the need for a federal media shield. S.2035 would create a statutory (as opposed to the current common law) standard that protects both freedom of the press and national security. More than 60 news media outlets and associations, as well as state officials and constitutional scholars support of this bipartisan legislation.
Major Provisions
Section 2: Compelled Disclosure from Covered Persons. The substitute amendment to S.2035 would prohibit a federal entity from compelling a covered person to testify, or produce a document, relating to protected information, unless a federal court determines by a preponderance of the evidence that:
1) the federal entity has exhausted all reasonably known alternative sources of the testimony or document;
2) in a criminal investigation or prosecution it is determined that:


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AFC Wimbledon midfielder Steven Gregory could barely hold back the tears when describing outward bound Terry Brown as a "father figure" and a "phenomenal" man.
Brown is thought to have offered his resignation on Tuesday night having bid what appeared to be an emotional farewell to fans after the 1-0 League Two defeat to Torquay United.
The club confirmed yesterday (Wednesday) that Brown and assistant manager Stuart Cash had left the club with first team coach Simon Bassey taking over as caretaker manager.
Speaking after the Torquay defeat, Gregory said the whole squad and backroom staff were incredibly emotional and despondent.
The 25-year-old, who spent two years with the Donsand helped them into the Football League before joining AFC Bournemouth in 2011, added that his relationship with Brown was the main reason he accepted a loan move last week.
Gregory said: "It is difficult to explain just how phenomenal Terry is and what he means to everyone here at the club.
"Personally speaking, he is like a father figure to me. When I was here previously, my own father passed away and Terry was amazing through it all.
"He is a massive part of why I wanted to come back and help the guys out."
He added: "Wimbledon is very close to my heart. I came here to win games and that has not happened, which is really disappointing. The dressing room is very emotional at the moment."
Among the favourites to take over the Dons' hot seat is former Brentford boss Andy Scott.
Scott said: "It would be disrespectful to talk about Terry's position until anything has been confirmed, but I am out of work and would be interested in any job that became available in League One or Two. I dearly want to get back into the game."
Gregory bemoaned his side's luck after a freak goal from Torquay's Rene Howe on Tuesday night condemned the Dons to their second home defeat on the bounce and led to the emotional scenes at the final whistle.
Gregory said: "It makes it harder to take because tonight's goal was a fluke and it led to a defeat and against Rochdale we were down to 10 men after 25 minutes and we were always going to struggle.
"It is so hard to take. Everyone in the changing room is gutted.
"The lads are working their socks off and giving it everything they have got. It is not a question of trying it is just sloppy mistakes.
"The goal was a fluke, but it came from a mistake. Winning is a habit and losing is a habit, when you're losing games it is so hard to turn it round."
He added: "But the support here is phenomenal. I've come from Bournemouth where they boo if you draw – you come here and when we were 2-0 down on Saturday, they were only booing the ref and cheering us.
"There is so much support for the players and, of course, Terry because he has done so much for the club."


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* iFit® wireless module included. Google Maps™ is a trademark of Google, Inc.
-3% Quick Decline™ Control
It's the newest revolution to the treadmill workout: decline training. Activate different muscle groups for faster results by walking at a decline, burn more calories than walking on a flat surface, and stimulate more muscle for faster results.
12 MPH QuickSpeed® Control
Accelerate your training with QuickSpeed controls. Boost your speed incrementally up to 12 MPH and get the workout intensity you need for any performance workout.
15% Quick Incline™ Control
Boost your performance with Quick Incline controls. Walking at an incline reduces impact on your joints, adds variety, and helps you burn more calories fast. Quick controls adjust your incline with the touch of a button—without interrupting your stride or rhythm.
Dual-Grip EKG™ Heart Rate Monitor with Polar® Wireless Chest Strap Included
Stay in your target heart rate zone with sensors built right into the handlebars. And if your style is hands-free, our included Polar® Wireless Chest Strap is a comfortable solution. Your reading is displayed on the console for a fast, accurate progress report helping you keep tabs on calories burned and cardiovascular conditioning.
2 HD Video Workouts
Run through the stunning Haleakala and beautiful Hana, Hawaii with these built-in HD video workouts. The incredible landscape not only inspires and motivates your workout, but the Performance 1850 treadmill automatically adjusts the incline and decline to match the terrain. Improve your form and technique with a personal trainer coaching you throughout your workout as well.
36 Workout Apps
Get the workout you want with 36 workout apps designed by a certified personal trainer. Choose from high-intensity, incline, speed, and calorie-burn workouts to get the results you want. The simple navigation of the apps makes it quick and easy to pick your workout and get going.
Compatible Music Port for iPod
Rock your workout to your favorite music. Simply plug your iPod** into the Intermix Acoustics 2.0 Sound System and listen to incredible sound through two 2-inch speakers.
**iPod is a trademark of Apple, Inc., registered in the U.S. and other countries. iPod® not included.
20" x 60" 2-Ply Commercial Tread Belt
This heavy-duty, 2-ply commercial-grade treadmill belt is designed to operate quieter than a normal tread belt—one more convenient component of a balanced drive system.
ProShox Plus™ Cushioning
Reduce impact on your joints up to 30 percent with this innovative cushioning. A comfortable walking, jogging or running surface protects your knees, ankles and back so you can stay comfortable. Four isolators absorb impact and relieve tension throughout your body.
AutoBreeze™ Workout Fan
Stay cool and refreshed with the fan that automatically changes the airflow to match the intensity of your workout. Or, if you prefer a definite setting, select low, medium or high.
SpaceSaver® Design with EasyLift™ Assist
This patented, revolutionary design allows your treadmill to fold vertically for storage. To make it even easier, this treadmill includes a powerful shock that will help lift the deck with an easy push.
This treadmill accommodates up to 375 pounds.
- 4.0 CHP Mach Z™ Commercial Pro Motor
- 10" Full-Color Touch Screen with Browser Powered by Android™
- iFit® wireless built in
- -3% Quick Decline™ Control
- 12 MPH QuickSpeed® Control
- 15% Quick Incline™ Control
- Dual-Grip EKG™ Heart Rate Monitor with Polar® Wireless Chest Strap Included
- 2 HD Video Workouts
- 36 Workout Apps
- Compatible Music Port for iPod
- 20" x 60" 2-Ply Commercial Tread Belt
- ProShox Plus™ Cushioning
- AutoBreeze™ Workout Fan
- SpaceSaver® Design with EasyLift™ Assist
For additional questions or concerns regarding this product, please contact the Manufacturer's Customer Service Department at 1.800.999.3756.
This agreement is between you, the Customer, the original purchaser of the product,
and GoConfigure. Services are not performed by GoConfigure or Sam's Club.
Terms and Conditions for Installation and Repair Services
Installations, Inc., doing business as GoConfigure, is a provider of services to consumers on
behalf of certain retailers relating to the installation and/or repair of equipment and
materials purchased by consumers from GoConfigure's retailer relationships (the "Services").
These Terms and Conditions explain GoConfigure's obligations to you ("Customer") and your
agreements with GoConfigure.
A service team representative will contact you to confirm the appointment within 2 business days of placing your order
Let GoConfigure professional installers get your purchase up and running
All of GoConfigure's installations are performed by licensed installers
With GoConfigure:
• Assembly will begin within 5 business days of delivery on most items and, in most cases, sooner
• They'll teach you how to get the most out of your new products
• Packaging materials are placed in preferred area on the purchaser's property
• All installation and/or repair services completed under the name GoConfigure are
completed by third party independent contractors that are selected at the sole discretion
of GoConfigure. GoConfigure uses reasonable commercial efforts to engage only qualified
contractors to perform the Services and who conform to GoConfigure's standards for
performance of Services.
• The relationship of GoConfigure and the contractor is that of an independent contractor.
The contractor is not an affiliate, partner, employee, agent or representative of
• GoConfigure will provide the contractor with the necessary information to, as applicable,
schedule the Services, and to timely pick up, deliver, install and/or repair the products at
Customer's location.
• Contractor is responsible for scheduling Services with the Customer. Scheduled service
dates may be subject to change due to inclement weather.
• Upon arrival, Customer should verify the identity of the contractor and if there is any
question or concern contact GoConfigure at 1.888.746.6887.
• Customer should ensure that all paths to the destination of the product must be clear of
furniture or personal belongings, from the curb to the room/location of choice.
• Customer must provide a designated location for placement by contractor of packaging
material upon completion of the Services.
• Customer will complete a final inspection of the product delivered, installed or repaired.
Upon inspection, if service is satisfactory the customer will be required to sign a
completion of services form, indicating the work has been satisfactorily completed. If
there are any issues with the Services or the products known at the time of the
provision of the Services, Customer must indicate such issues in writing to the
• Customer requests for additional services, claims, complaints or compliments should be
directed to 1.888.746.6887.
• Contractors are not responsible for the damage to underground systems, security fence,
sprinkler, pet fence, pipe, etc. Prior to Services for installation, Customer is responsible for
obtaining all utility entity and local government permissions that may be applicable.
• An adult at least 18 years of age or older must be at the home during the performance by
the contractor of the Services and authorized by the Customer to sign off upon completion
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• If Customer needs to reschedule a Services appointment with a contractor, Customer must
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they service.
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• GoConfigure provides a 30-day limited warranty on all installation and repair
services. GoConfigure warrants that the Services will be free from any defect in
workmanship for a period of 30 days from the date of completion.
• This limited warranty does not cover damage from acts or occurrences beyond the
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• This limited warranty does not cover any defects in the manufacture of the product being
delivered, installed or repaired by the contractor (such defects may be covered under the
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• The GoConfigure warranty of services only covers the original Customer and is not
• The warranty shall not be applicable in the event of any misuse or abuse of the product or
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• Some states do not permit certain limitations of warranties, including the limitation of
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This treadmill features a Lifetime Frame Warranty, Lifetime Motor Warranty, Lifetime Deck Warranty, 5-Year Parts & Electronics Warranty, and a 2-Year Labor Warranty


text:
Newman awards college scholarships to 11 Dallas students
DALLAS -- Terence Newman's Rising Stars Foundation, the official charity of Dallas Cowboys cornerback Terence Newman, awarded 11 recently graduated Dallas ISD students with $5,000 college scholarships. These students were all members of the foundation's mentoring program.
Newman launched his foundation in 2007 to benefit and support some of the most promising young student-athletes in the Dallas Independent School District during their high school years. Each year since, the foundation has selected 10 freshmen from a pool of students nominated by teachers, administrators and coaches, to become members of Newman's program. In addition to providing tutoring assistance through Sylvan Learning Center, Newman has also taken the students on regular outings which include community service projects, movies, bowling, and even to the Dallas Mavericks' practice facility to play basketball.
Ten of the 11 program participants who recently received their scholarships were members of the foundation's first class. One (Galen Durden) was a member of the program's second class and graduated a year early.
"I wanted to give the kids that have potential to become leaders and positive examples for this community an opportunity to reach that potential," Newman said. "I am excited to provide these scholarships to these 11 great young men. I have gotten to know them very well over the last four years, and they are all good students and very good people. They all have a very promising future, and I am happy that those scholarships will help them achieve their goals."
The students in the program are now attending the following schools: Sam Houston University, Henderson State University, University of Texas - Arlington, Wiley College, University of Memphis, University of Texas - Austin, Mountain View College, University of North Texas, Texas A&M Commerce.
Terence Newman Can Still Get the Job Done
2011 Stats:
Tackles: 53
Forced Fumbles:
Recovered Fumbles:
Interceptions: 4


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Gooey, chocolaty—and light, at about 100 calories per cookie.
See the recipe »
Kat Teutsch
Adding bitter cocoa to the mix balances the sweetness. Just 54 calories per cookie.
Sang An
At 69 calories, these tasty treats are worth sharing.
You'll get a delicious dose of heart-healthy fat and antioxidants, courtesy of the nuts and cocoa (and just 55 calories each!).
Dress up this chewy classic with a festive, to-die-for drizzle of chocolate. And replacing oats for part of the coconut makes this a low-fat holiday option, with 52 calories per cookie.
These precious bites are certainly tasty at just 52 calories.
Pretty, yummy and so worth it at 44 calories.
Shhh, don't tell and they'll never know: These "doughnuts" are just 28 calories each.
Use your favorite raspberry preserves and give these treats (just 39 calories per cookie) to friends!
Canned pumpkin helps make these cookies a quick bake (46 calories per cookie).
Fun, guilt-free treats—from chocolate ganache-filled to orange-coconut-topped.
10 Gluten-Free Holiday Cookies We Love
Healthy Holiday Cookies
A No-Stress Guide to Hosting the Perfect Holiday Party


text:
As an Associate Veterinarian:
You will be able to make independent medical decisions, continually grow and learn as a veterinary professional, as well as fulfill a higher purpose by improving the quality of life for millions of pets across the United States. You will also have the opportunity to work alongside a highly trained team, providing the best preventive care possible for both clients and their pets, improving the quality and business performance of our veterinary hospital.
A typical day for an Associate Veterinarian:
Will include performing all surgeries, including the use of all medical instruments and equipment. You will diagnose, treat and control diseases and injuries in pets, prescribe and administer drugs and vaccines and educate clients on all aspects of pet health, including Optimum Wellness Plans®.
The Associate Veterinarian will need an educational background of at least:
Benefits of an Associate Veterinarian:
Take a look at the following link to find out more about these benefits and what else we have to offer: http://www.banfield.com/benefits
Who We Are:
With over 927 hospitals in 43 states and Puerto Rico, we have become the number one choice for providing high-quality preventive care in the veterinary industry. As a member of the Mars Incorporated family, we believe strongly in giving back. Our associates volunteer for activities at a wide range of nonprofit organizations across the country. From cleaning up city dog parks and painting local shelters, to packing pet food and everything in between, we celebrate putting Mars' principles into action in the communities where we live, work and play.
Banfield Pet Hospital is committed to a diverse work environment in which all individuals are treated with respect and dignity. It is our mission to provide equal employment opportunities to all candidates and to ensure that access to jobs.
Please contact Andrew Cowley at firstname.lastname@example.com to find out more about a rewarding career opportunity in your area!
If this position is not be the perfect fit, but there's another way you could see yourself working with us, feel free to reach out to email@example.com
The University of Tennessee Institute of Agriculture
Knoxville, TN 37996
Personnel Directory
Disclaimer · Indicia · EEO/AA Statement/Non-Discrimination Statement


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This game was classified by the community with the following category scores - Violence=0/3, Sex=0/3, Mature Content=0/3. Avoid the hazards as you race three other players (human or AI) to collecting the most elements. Can you avoid getting trapped while trying to trap your opponents? Or will you just go for the elements and ignore your opponents, the choice is yours in Element... Another release from LoneWolf Studios
Buy Xbox content on Xbox.com. Your Xbox 360 console will automatically download the content next time you turn it on and connect to Xbox Live.Learn More


text:
One of the pillars of modern aviation safety, cockpit resource management was introduced to commercial aviation more than two decades ago. Among other things, CRM was meant to draw the curtain on the era of the submissive copilot and flight engineer cowed by an overbearing "gear up, shut up" captain. It also addressed the disturbing incidence of three-pilot airline crews, nursing deep grievances born of unwanted post-deregulation mergers, refusing to speak to each other on the flight deck.
In aviation, silence is golden only under the flight path and in the comforts of an aircraft's cabin, and CRM encourages everyone in the cockpit, regardless of seniority, to work together and speak up if they see something that strikes them as amiss, questionable, wrong, illegal, stupid, negligent or any other troubling adjective that could create a hazard or confusion. Post-9/11 security billboards have adopted this theme too: "If you see something, say something."
All of this well intentioned stuff, along with the OSHA-enforced whistleblower provision of the Wendell H. Ford Aviation Investment and Reform Act for the 21st Century (AIR21), serves as backdrop to a recent OSHA decision that ordered AirTran Airways (the former ValuJet of Everglades inferno infamy) to rehire a pilot it fired in 2007 following what it described as a sudden spike in his mechanical-malfunction reports. A week after the airline hauled the pilot in for a 17-minute hearing on the matter, it fired him for not adequately explaining the surge in reported squawks. OSHA disagreed, asserting that the airline's decision to fire the pilot was retaliatory, and ordered AirTran to pay the pilot more than $1 million in back wages, plus interest and compensatory damages.
"Airline workers must be free to raise safety and security concerns, and companies that diminish those rights through intimidation and retaliation must be held accountable," said David Michaels, the head of OSHA.
Since news of the agency's decision broke, discussion among those with careers in cockpits has run the gamut: to some, this pilot deserves admiration for taking a stand; others question why only he among all AirTran's pilots seemed to find so much wrong with his airline's equipment; others label him a troublemaker; others wonder if he has won this game but spectacularly lost the wider set and match of a long and rewarding piloting career, suggesting he may never find another piloting job beyond AirTran and Southwest, which bought AirTran last May.
Labor Department policy prohibits it from releasing the AirTran pilot's name, but it'll percolate out through other channels. If you were running a flight department, would your gut regard him as a courageous whistleblower or a malcontent? Would you at least interview the fellow? Or would you reject him out of hand because he was fired by an airline? Scroll down this page to send your thoughts.
david laden (not verified)
January 26, 2012 - 2:00pm
at on time valujet bought 9 dc-9 30's for 10 mill. from turky and were fixed in lake city fl. if it was one of these planes he got it right
lee carson (not verified)
January 28, 2012 - 11:52pm
I certainly would hire this individual, grant him chief pilot status and respect him professional conduct exhibited in his decision with AirTrans.
May 27, 2014 - 10:59am
Simply yesterday, Southwest Airlines chose to ground 40 planes to do further examination. Air transport travelers have a right to be protected when they fly. The carriers most likely let their travelers down in light of the fact that they demonstrated they will bring down the bar a little to spare a buck. In any case, I will say that Southwest Airlines is an extremely protected air transport with an extraordinary wellbeing record. The avionics business has had years of magnificent wellbeing too. In any case theres' dependably that capability of a mishap. So when you bring down the models even simply a bit, you may not draw near to smashing a plane however you are bringing down the edge of wellbeing.physics homework help


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MORGANTOWN, W.Va. — The $106 million master plan for West Virginia University athletic facilities took a step closer to finalization at Friday's Board of Governors meeting.
The BoG approved the plan, which covers a variety of expansion and renovation projects and additions to venues on campus, and forwarded it along to the Higher Education Policy Commission. It meets later this month and final approval there will turn the idea and the financing into reality.
The university plans to fund the various projects with $75 million from an $85 million bond, $25 million in private donations through the Mountaineer Athletic Club and $6 million from the capital expenditure fund contained within the multimedia rights contract with IMG College.
Additionally, WVU will pay the bond with income guaranteed from membership in the Big 12 Conference and the affiliation with IMG College.
The football program will see a new team meeting room inside the Puskar Center and Milan Puskar Stadium will have concourse areas expanded to accommodate larger entrance gates and enhanced concession stands and restrooms. Both will be financed by the bond and designed by the Iowa-based architectural firm Heery International. That group has been contracted in the past for similar work at Southern Miss and Atlanta's Georgia Dome and Turner Field.
Up to four LED boards will be added to the interior bowl of the stadium while the gray walls circling the sidelines will be decorated with graphic coverage. Outside the Coliseum, a marquee will be added to advertise events at the intersection of Monongahela Boulevard and Patteson Drive. Money from the contract with IMG College will pay for each.
Those projects will begin in the initial wave of work this year.
The master plan will also consider improvements at other facilities at a later date. Inner concourse suites, private boxes, renovated restrooms and concession stands and an expanded concourse area could come to the Coliseum. A new indoor track could be added to the Shell Building.
The Shell, the swimming and diving team's Natatorium and the tennis courts could all receive needed renovations. Other varsity sports could have new weight rooms and home and visitor locker rooms and Hawley Field, soon to be the former home to the baseball team, will be repurposed in a manner yet to be determined.
Contact sportswriter Mike Casazza at email@example.com or 304-319-1142. His blog is at blogs.dailymail.com/wvu. Follow him on Twitter at @mikecasazza.


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American Honda today reported September 2013 U.S. sales of 105,563 units, a decrease of 9.9 percent compared with September 2012 (a decrease of 2.1 percent based on the Daily Selling Rate (DSR*)), while year-to-date sales remain up 7.9 percent over 2012. Reflecting Honda's consistent focus on retail sales, the Honda brand posted September 2013 sales of 93,915 units, a decrease of 8.7 percent compared with September 2012 (a decrease of 0.7 percent based on the DSR). Acura U.S. September sales of 11,648 units decreased 18.9 percent compared with September 2012 (a decrease of 11.9 percent based on the DSR).
"Even as we catch our breath from all-time record August sales and with two fewer selling days this month, the Honda brand continues on a strong pace for the year," said John Mendel, executive vice president of sales at American Honda. "The already strong appeal of the Accord lineup will grow even greater with the launch late this month of the 2014 Accord Hybrid, which delivers 50 mpg1 city EPA-rated fuel economy."
"With the all-new 2014 MDX luxury SUV hitting the sweet spot for upscale family shoppers, Acura is well positioned heading into the fall selling season," said Jeff Conrad, vice president of Acura sales.
*The daily selling rate (DSR) is calculated with 23 days for September 2013 and 25 days for September 2012. Year-to-date, the DSR is calculated with 229 days for 2013 and 230 days for 2012. All other percentages in release are unadjusted; see table for adjusted DSR figures.
1Based on 2014 EPA mileage ratings. Use for comparison purposes only. Actual fuel mileage will vary depending on driving conditions, how the vehicle is driven and maintained, lithium-ion battery age/condition, and other factors.
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Do I need disability insurance?
Everyone who works and earns a living probably needs disability insurance. If you suddenly became disabled and were unable to work, could you still meet your financial obligations? Could you get by without having to use savings or borrow from relatives? If not, you'll want to make sure that you have adequate disability insurance coverage that is designed to pay your expenses while you are disabled and cannot work.
Because you have to meet a strict definition of disability to qualify for benefits from government programs (e.g., Social Security), you shouldn't rely on them as your only sources of income if you became disabled. Instead, find out if you have group disability insurance through your employer. It may be paid for by the company, or you may pay part of the premium. If disability coverage is not available at work or if you are self-employed, you should consider purchasing an individual policy from a private insurer. Most policies pay between 50 and 70 percent of your gross income and can last anywhere from a couple of months to age 65.


text: The Scoobies mysterious new foes have obtained a powerful instrument that may destroy everything that Buffy has worked so hard to build. Acclaimed screenwriter, Drew Goddard continues his fun-filled romp through Tokyo with Wolves at the Gate part 3. The critically acclaimed Buffy Season Eight continues with Joss Whedon as executive producer, with Georges Jeanty as series artist, and Jon Foster on covers. Written by acclaimed television scribe Drew Goddard!


text: Expects 55 Percent of its 'Triples' Switching to New Corn Refuge Products in 2012; Updates Soybean Herbicide Tolerance Pipeline DuPont will confirm its seed business, Pioneer Hi-Bred, shows strong early financial results through volume gains and price improvements for this season during today's Deutsche Bank Global Industrials and Basic Materials Conference. "Pioneer is on pace for strong growth in its global business in 2011," said Paul E. Schickler, Pioneer president. "In North America where the planting season is coming to a close, we anticipate an increase in corn and soybean market share coupled with mid single-digit price increases, in line with our objectives." Schickler attributes the 2011 North America success to Pioneer's year-round focus on helping customers address their unique needs through its Right Product Right Acre strategy. Corn Seed Business "Strong customer demand in North America for our newest corn hybrids and Optimum® AcreMax® 1 system coupled with a smooth integration of the PROaccessSM business are key sales growth drivers in 2011," Schickler said. "Growers see the benefits of our Optimum® AcreMax® products and have planted this new product on almost 4 million acres this year, exceeding our expectations," said Schickler. "Pioneer plans to build on the Optimum® AcreMax® 1 success with new integrated and reduced refuge product choices for growers in 2012, including Optimum® AcreMax® Insect Protection and Optimum® AcreMax® Xtra Insect Protection." Schickler said approximately 55 percent of Pioneer's 2012 above and below ground lineup of triple-stack products containing Herculex® XTRA will be converted to AcreMax® 1 products. "Managing refuge requirements for triple stacks is a larger challenge for farmers due to the in-field refuge requirement, and they are responding well to the solutions we have developed," he said. Soybean Seed Business "Our brand leadership in soybeans since 1989 is a testament to the value and trust growers place in Pioneer® brand soybean products, which have consistently demonstrated strong yields and exceptional agronomic and disease resistance advantages," said Schickler. He said the 29 new Pioneer soybean varieties for 2011 - developed for specific grower needs and locations - is an example of the stream of innovation which will help deliver further growth for the soybean business in 2012 and beyond. As part of a product pipeline update, Schickler noted regulatory approval and commercialization plans for Optimum® GAT® soybeans are delayed by Monsanto's actions, which are preventing the regulatory review of the stack. "We continue to work toward legal resolution regarding Optimum® GAT® soybeans to bring our first-choice innovation in expanded herbicide tolerance to the market," said Schickler. "Our momentum in the marketplace is strong as we deliver superior products and services to growers. The depth of our soybean research programs will enable us to provide innovative products well into the future." As an example, Pioneer is working with a broad range of trait technologies with tolerance to herbicides such as glyphosate, auxins, glufosinate and ALS to help farmers manage weeds that have developed resistance to certain herbicides. The Pioneer research pipeline includes a late decade introduction of its elite soybean genetics with the Dow AgroSciences' EnlistTM trait and glyphosate trait options including the original Roundup Ready® technology, pending regulatory approval, Schickler said. Segment Outlook "The fundamentals of agriculture remain solid," said Schickler. "Last December, DuPont announced its expectations for sales and pre-tax operating margin growth through 2015 for the Agriculture & Nutrition reporting segment, which included the seed, crop protection and nutrition and health businesses. Those expectations remain unchanged as these businesses, in the aggregate, are expected to deliver sales at a compounded annual growth rate of 8 to 10 percent from 2010-15 and increase pre-tax operating margins in the range of 19 to 21 percent in the same time period." The preceding segment information does not reflect the recent Danisco acquisition either on a pro forma or forward-looking basis. The company expects to have integrated financial data beginning with the reporting of its second quarter 2011 earnings results. The full presentation scheduled for 11 a.m. EDT is available in the Investor Center at Pioneer Hi-Bred, a DuPont business headquartered in Des Moines, Iowa, is the world's leading developer and supplier of advanced plant genetics, providing high-quality seeds to farmers in more than 90 countries. Pioneer provides agronomic support and services to help increase farmer productivity and profitability and strives to develop sustainable agricultural systems for people everywhere. Science with Service Delivering SuccessTM. DuPont is a science-based products and services company. Founded in 1802, DuPont puts science to work by creating sustainable solutions essential to a better, safer, healthier life for people everywhere. Operating in more than 90 countries, DuPont offers a wide range of innovative products and services for markets including agriculture and food; building and construction; communications; and transportation. Forward-Looking Statements: This news release contains forward-looking statements based on management's current expectations, estimates and projections. The company does not undertake to update any forward-looking statements as a result of future developments or new information. All statements that address expectations or projections about the future, including statements about the company's strategy for growth, product development, market position, expected expenditures and financial results are forward-looking statements. Some of the forward-looking statements may be identified by words like "expects," "anticipates," "plans," "intends," "projects," "indicates," and similar expressions. These statements are not guarantees of future performance and involve a number of risks, uncertainties and assumptions. Many factors, including those discussed more fully elsewhere in this release and in DuPont's filings with the Securities and Exchange Commission, particularly its latest annual report on Form 10-K, as well as others, could cause results to differ materially from those stated. These factors include, but are not limited to changes in the laws, regulations, policies and economic conditions of countries in which the company does business; competitive pressures; successful integration of structural changes, including acquisitions, divestitures and alliances; research and development of new products, including regulatory approval and market acceptance, and seasonality of sales of agricultural products. 06.15.2011


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Find hotels & motels in Neptune using the list below. Search for cheap and discounted hotel and motel rates in or near Neptune, NJ for your upcoming personal or group trip. Discover the best Neptune New Jersey hotel/motel rooms. Review the Neptune hotel list below to find the perfect lodging. We also have a map of the Neptune hotels. Need 5+ Rooms? Secure Neptune Group Hotel Deals
The Neptune center point is approximately 1 mile west of Memorial United Methodist Church and 1 mile southeast of Jersey Shore Outlet Mall.
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