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Table Of Contents
Release Notes for the Cisco 10000 Series ESR
for Cisco IOS Release 12.0(17)SL4
Upgrading to a New Software Release
Upgrading Cisco IOS Software from Earlier Cisco IOS Releases
New Features in Cisco IOS Release 12.0(17)SL
Cisco 10000 Series ESR Software Features
Automatic Protection Switching Support
Testing Performance of High-Speed Interfaces
Resolved Problems in Cisco IOS Release 12.0(17)SL4
Resolved Problems in Cisco IOS Release 12.0(17)SL3
Resolved Problems in Cisco IOS Release 12.0(17)SL2
Resolved Problems in Cisco IOS Release 12.0(17)SL1
Caveats in Cisco IOS Release 12.0(17)SL
Resolved Problems in Cisco IOS Release 12.0(17)SL
Obtaining Technical Assistance
Contacting TAC by Using the Cisco TAC Website
Release Notes for the Cisco 10000 Series ESR
for Cisco IOS Release 12.0(17)SL4
November 19, 2001
These release notes provide information about Cisco IOS Release 12.0(17)SL4 running on the Cisco 10000 series edge services router (ESR). They are identical to the release notes for Cisco IOS Release 12.0(17)SL3, but were updated to include fixes for caveats discovered and resolved since Cisco IOS Release 12.0(17)SL3 (see the "Resolved Problems in Cisco IOS Release 12.0(17)SL4" section).
These release notes are updated as needed to describe new features, memory requirements, hardware support, software platform deferrals, and changes to the microcode and related documents.
Cisco IOS Release 12.0(17)SL4 is based on these previous releases:
•Cisco IOS Release 12.0(17)SL3
•Cisco IOS Release 12.0(17)SL2
•Cisco IOS Release 12.0(17)SL1
•Cisco 12.0ST features synchronized with Cisco IOS Release 12.0S
For a list of the software caveats that apply to Cisco IOS Release 12.0(17)SL, see the "Caveats in Cisco IOS Release 12.0(17)SL" section.
Use these release notes in conjunction with the Release Notes for Cisco IOS Release 12.0(S) and the cross-platform Release Notes for Cisco IOS Release 12.0.
To review the release notes for Cisco IOS Release 12.0S, go to www.cisco.com and click Technical Documents. Select Release 12.0 from the Cisco IOS Software drop-down menu. Then click Release Notes > Cisco 12000 Series Routers > Cisco 7000 Family and 12000 Series—Release Notes for Release 12.0 S.
To review the cross-platform Release Notes for Cisco IOS Release 12.0, go to www.cisco.com and click Technical Documents. Select Release 12.0 from the Cisco IOS Software drop-down menu. Then click Release Notes > Cross-Platform Release Notes.
This document contains the following sections:
•Upgrading to a New Software Release
•New Features in Cisco IOS Release 12.0(17)SL
•Cisco 10000 Series ESR Software Features
•Resolved Problems in Cisco IOS Release 12.0(17)SL4
•Resolved Problems in Cisco IOS Release 12.0(17)SL3
•Resolved Problems in Cisco IOS Release 12.0(17)SL2
•Resolved Problems in Cisco IOS Release 12.0(17)SL1
•Caveats in Cisco IOS Release 12.0(17)SL
•Resolved Problems in Cisco IOS Release 12.0(17)SL
•Obtaining Technical Assistance
Upgrading to a New Software Release
For specific information about upgrading your Cisco 10000 series ESR to a new software release, see the Cisco 10000 Series ESR Software Configuration Guide.
For general information about upgrading to a new software release, see the product bulletin Cisco IOS Upgrade Ordering Instructions located at:
For additional information about ordering Cisco IOS software, refer to the Cisco IOS Software Releases URL:
Upgrading Cisco IOS Software from Earlier Cisco IOS Releases
Caution If you are upgrading your Cisco 10000 series ESR from Cisco IOS Release 12.(14)SL or from earlier 12.0(x)SL-based releases, read this section.
Before you upgrade to Cisco IOS Release 12.0(17)SL4, save your current configuration file. If you decide to re-install Release 12.0(14)SL, or an earlier release, you must also re-install the configuration file associated with that release. This is because some BGP configuration-file entries in Release 12.0(17)SL4 are not compatible with Release 12.0(14)SL or earlier releases.
System Requirements
We recommend that you use 512 MB of memory on the Performance Routing Engine (PRE). New PREs are shipped with 512 MB of memory. In a redundant setup, both PREs should have the same amount of memory.
New Features in Cisco IOS Release 12.0(17)SL
The following new features and improvements are supported in Cisco IOS Release 12.0(17)SL:
•Multiple Quality-of-Service (QoS) matches per phase—QoS matching logic was optimized to handle multiple non-ACL matches, with up to four matches in a single pass when the matches are in separate class maps.
•QoS classification for voice traffic—Support was added for Real Time Protocol (RTP) to provide high priority classification for voice traffic.
•QoS Priority Queueing (PQ)—Ensures minimum latency for delay-sensitive traffic.
•QoS Class-Based Weighted Fair Queueing (CBWFQ)—Allows you to configure a portion of interface bandwidth for several different classes of traffic.
•Frame Relay Traffic Shaping (FRTS)—A method of limiting excess traffic on a Frame Relay interface at the PVC level.
•Generic Traffic Shaping—A method of limiting excess traffic at the interface level.
•802.1q PXF switching for ARPA encapsulation—Supports the ability to link individual VLANs to MPLS VPNs.
•Per-Packet Load Balancing (PPLB)—Ensures load balancing over multiple links by allowing the router to send successive data packets over paths, without regard to individual hosts or user sessions. PPLB uses a round-robin method to determine which path each packet takes to arrive at the destination.
•ATM PVCs—The Cisco 10000 series ESR now supports 4000 ATM PVCs.
Cisco 10000 Series ESR Software Features
Table 1 lists the features supported in the Cisco 10000 Series ESR.
Table 1 Principal Software Features
Cisco Discovery Protocol (CDP)
Simple Network Management Protocol (SNMP)
SONET 1+1 Automatic Protection Switching (APS)
Route Processing Redundancy Plus (RPR+)
High-Level Data Link Control (HDLC)
Frame Relay
Point-to-Point (PPP)
Multilink Point-to-Point (MLP)
Multiprotocol Label Switching
Multiprotocol Label Switching Virtual Private Network (MPLS/VPN) edge services
802.1q PXF switching for ARPA encapsulation
Multicast Features
Multicast Static Routes
Multicast Routing Monitor (MRM)
Multicast Services
Internet Group Management Protocol (IGMP)
Protocol-Independent Multicast (PIM)
Distance Vector Multicast Routing Protocol (DVMRP)
Cisco Group Management Protocol (CGMP)
Unidirectional Link Routing (UDLR)
Session Directory Protocol (SDP)
Multicast Source Discovery Protocol (MSDP)
Border Gateway Protocol (BGP)
Quality of Service
Committed Access Rate (CAR)
Class-Based Weighted Random Early Detection (CBWRED)
QoS Policy Propagation on BGP (QPPB)
Priority Queueing (PQ)
Class-Based Weighted Fair Queueing (CBWFQ)
Frame Relay Traffic Shaping (FRTS)
Generic Traffic Shaping (GTS)
Routing Protocols
Border Gateway Protocol (BGP)
Intermediate System-to-Intermediate System (IS-IS)
Open Shortest Path First (OSPF)
Interior Gateway Routing Protocol (IGRP)
Enhanced Interior Gateway Routing Protocol (EIGRP)
Routing Information Protocol (RIP)
Security Features
Standard and extended access lists
Authentication, Authorization, and Accounting (AAA)
Kerberos authentication and client support on Telnet
Radius authentication
Terminal Access Controller Access Control System Plus (TACACS+)
Limitations and Restrictions
This section describes any limitations and restrictions that you should review before you use the Cisco 10000 series ESR.
Automatic Protection Switching Support
Automatic protection switching (APS) is supported on the OC-12 Packet Over SONET (POS) and Channelized OC-12 (ChOC-12) line cards with this release. However, certain limitations apply if the PRE installed in your system is the ESR-PRE. These limitations do not apply to the ESR-PRE1. You can verify which PRE is installed in the ESR by using the show version command.
For APS to work properly with the ESR-PRE, you must ensure that the OC-12 POS or ChOC-12 line card is installed in the lower-numbered (odd) slot.
The system receives clocking information from the line card in the odd slot. If you remove the odd-numbered card (or if the clocking mechanism on that card fails), the clocking is lost and the data path is shut down (Caveat CSCdr81416).
As a workaround, we recommend the following:
1. For the card pair, fully configure the lower-numbered card, and leave the higher-numbered card set to its default configuration.
2. Before you remove a card from the odd slot, run the no associate command and shut down the card. The following is an example of disabling APS for cards in slots 3 and 4:Router(config)# redundancyRouter(config-r)# no associate 3 4Router(config-r-a-sl)# exitRouter(config)# interface pos 3/0/0Router(config-if)# shutdown
You can now remove the card in slot 3.
3. Move the card located in the even slot to the odd slot and enter the no shutdown command. Traffic flow resumes. Insert a new card into the even slot and reconfigure the pair for redundancy.
Testing Performance of High-Speed Interfaces
Cisco IOS Release 12.0(17)SL is enhanced with multiple queues for all classes of traffic over high-speed interfaces. The software selects a queue based on the source and destination address for the packet. This ensures that a traffic flow always uses the same queue and the packets are transmitted in order.
When the Cisco 10000 series ESR is installed in a real network, the high-speed interfaces work efficiently to spread traffic flows equally over the queues. However, using single traffic streams in a laboratory environment may result in less-than-expected performance.
Therefore, to ensure accurate test results, you should test the throughput of the gigabit Ethernet, POS, or ATM uplink with multiple source or destination addresses.
Tip To determine if traffic is being properly distributed, use the show hardware pxf cpu queue command.
Important Notes
This section contains issues that you should be aware of with Cisco IOS Release 12.0(17)SL.
Inserting a New Line Card
If you insert a new line card into the Cisco 10000 series ESR chassis, the line card initially reports that the line is up.
Frame Relay and PPP Sessions
You can run up to 4200 Frame Relay sessions or 1300 PPP sessions, and you can configure up to 800 BGP peers on the Cisco 10000 series ESR. The router also supports up to 512 Multilink Point-to-Point (MLP) protocol sessions.
Note Each T1 interface in an MLP bundle represents a single PPP session. Thus, if you configure 130 MLP bundles of 10 T1 interfaces, each results in 1300 PPP sessions (which is the maximum number of PPP sessions that are supported on the Cisco 10000 series ESR).
Cisco Discovery Protocol
Starting with Cisco IOS Release 12.0(15)SL, the Cisco Discovery Protocol (CDP) is disabled by default. You can enable CDP on an interface using the cdp enable command.
Resolved Problems in Cisco IOS Release 12.0(17)SL4
This section lists problems that were found and resolved in Cisco IOS Release 12.0(17)SL4.
If you used the no t1 t1-number channel-group channel-group-number command to remove multiple T1 channels, and then reconfigured the same T1 channels, the output of the show ppp multi interface multilink number command would sometimes show the same member as active and inactive at the same time. This has been fixed.
Previously, the output counter on an interface did not work properly when the output queue size was changed. This has been fixed.
Previously, if you added or deleted serial links from the MLPPP bundle, the MLPPP interface showed erroneous input statistics. This no longer occurs.
A small percentage (less than 10%) of OC-12 ATM and OC-3 ATM line cards failed to boot while under the control of Cisco IOS software due to an unexpected Systems Error (SERR) interrupt. This has been fixed.
A problem between the release of Cisco IOS Release 12.0(15)SL and 12.0(17)SL occurred in which upgrading Cisco IOS software on some ATM networks failed because all packets, after a few seconds, were marked as ignored input errors. This no longer occurs.
Previously, when a VC was being OAM managed and the VCs were oversubscribed, the status of the VCs could continually change between up and down. This has been fixed.
Due to a race condition in the SAR firmware, in rare circumstances it was possible for a VC to become stuck in a close pending state and become unusable. This no longer occurs.
Previously, the Cisco 10000 series ESR did not respond to a traceroute if the destination IP address was in the range of x.x.x.224 to x.x.x.239. This has been fixed.
Previously, if you configured mcast, with multiple uplinks over ATM, the mcast connection could timeout every three minutes, requiring that the mcast groups be recreated.
Resolved Problems in Cisco IOS Release 12.0(17)SL3
This section lists problems that were found and resolved in Cisco IOS Release 12.0(17)SL3.
Previously, you could not ping the Cisco 10000 series ESR over the PPLB group. This no longer occurs.
When a recursive route was added and all of its output interfaces were configured as per-packet load sharing, packets switched to this new route were per-destination load-shared. This has been fixed.
If multiple prefixes were configured through PPLB-enabled interfaces, and all the output interfaces of the router were configured for per-packet load sharing, and you added a recursive route, the packets switched through this new route were per-destination load-shared. This no longer occurs.
When large FDL packets of invalid lengths were received by the channelized ChOC-12 line card, the contents of the packet were printed on the line card console. In the case of a large FDL packet, excessive printing on the line card console caused the line card to reset. This has been fixed.
Resolved Problems in Cisco IOS Release 12.0(17)SL2
This section lists problems that were found and resolved in Cisco IOS Release 12.0(17)SL2.
If you preconfigure a line card using the card command, PRE performance is no longer affected.
The access level issue that occurred when using the Web interface has been corrected.
If you enter the wr mem command, the router no longer fails.
A PFX stall error with 126 multilink PPPs in a QoS configuration no longer occurs.
Priority queues no longer experience tail drops when the line card is under heavy load.
Duplicate caveat, which was resolved (see CSCdu73749).
When you unconfigure and configure the router using the copy tftp run command, the router no longer stops responding.
A large increase in latency for multilink PPP bundles combined with an increase in the number of packet tail drops no longer causes a dramatic decrease in performance.
Duplicate caveat, which was resolved (see CSCdv12192).
The PXF stall error no longer occurs in column 6 during low traffic.
There is no longer a slow buffer leak when you run multicast input on MLP.
There is no longer a buffer leak in multilink PPP column 7.
Resolved Problems in Cisco IOS Release 12.0(17)SL1
This section lists problems that are resolved in Cisco IOS Release 12.0(17)SL1.
If you enter the dir disk0/1 command at the rommon prompt, a TLB (Store) Exception error message no longer appears.
If the router receives an IP packet with Ethernet padding over the MLP bundle, it now properly passes the packet to the line card.
When the router was configured with large numbers of routes, clearing the entire routing table caused high CPU use. In rare cases, the line cards or Cisco IOS software rebooted. This problem no longer occurs.
Caveats in Cisco IOS Release 12.0(17)SL
Table 2 describes the caveats for the Cisco 10000 series ESR running Cisco IOS Release 12.0(17)SL.
Table 2 Cisco IOS Release 12.0(17)SL Caveats
Caveat Description
If you configure a DS3 BERT pattern 2^20-O153 on any unchannelized DS3 (by using the bert pattern 2^20-O153 interval 1-14400 command), and you then connect the line card to T-Bird 310 test set, the pattern does not synchronize with T-Bird 310.
Workaround: Use a different BERT pattern.
The router sends out DHCP INFORM and DISCOVER messages containing an incorrect Ethernet address.
Workaround: No workaround is necessary. This caveat is harmless because these DHCP messages are not used to acquire IP addresses. They are used to gather environmental data such as the domain name server address.
When you use the Frame Relay autosense feature, the Cisco 10000 series ESR sends all three LMI status message types immediately after the interface starts responding. However, sometimes the switch at the other end is not ready to receive messages and as a result, misses one or two messages that were sent. LMI autosense waits until the next scheduled interval (default is 1 minute) to send the messages again.
This problem primarily affects clear channel CT3 interfaces.
Workaround: There is currently no workaround.
If you configure an STS-1 on a ChOC-12 line card as unchannelized and then configure the remote side to send idle-character marks (namely, 0xFF), the T3 line stops responding and transmits a Remote Alarm Indication (RAI).
Workaround: When you use unchannelized T3 mode, configure the remote side to send idle-character flags (0x7E). To set this value, use the interface configuration mode idle-character command.
When you send large numbers of packets from the Gigabit Ethernet line card to the PRE in the Cisco 10000 series ESR, you may lose a small number of packets. This only occurs for some packet sizes at very high bandwidths, with loss rates of a few parts per million.
Workaround: There is currently no workaround.
If large MLP configurations are in use, and you attempt to copy the configuration from a TFTP server directly into the running config, the copy may fail. Failures may include interfaces not appearing, or IPCP or LCP states not opening correctly.
Workaround: These failures are far less likely to occur if the configuration is copied to bootflash, and then from bootflash to the running config. Copy the configuration file to the startup config and then reload the router.
Limited support exists for APS. For detailed information, refer to the "Automatic Protection Switching Support" section.
On rare occasions, the system cannot retrieve remote performance data if you are using a ChOC-12 line card that has its T1s configured with ANSI FDL enabled.
Workaround: There is currently no workaround.
WRED does not drop outbound packets correctly on the Channelized T3 line card (CT3) in the default WRED configuration.
Workaround: Change the WRED policy to a non-default value.
The Flash disk can fall into the chassis when you insert the disk into the empty space to the right of the slot B in the PRE flash assembly.
Workaround: Pay extra attention when inserting a flash disk into the PRE flash assembly. Do not insert the disk in the empty space to the right of the slot B—if you insert a card in that space, it will fall into the chassis.
Some MPLS packets are CEF switched when they should be label switched. This condition occurs if the Cisco 10000 series ESR has two interfaces configured for label switching.
Workaround: Configure only one interface for label switching.
The default logging parameter (logging rate-limit console all 10 except critical) sets console logging to disabled.
Workaround: Enter the logging console critical command to view the most important events such as card up/down and toaster failure events.
Mass configuration (which occurs during boot/reload and can occur during link state changes) takes a long period of time (for example, more than 40 minutes for 2000 VCs associated with a main interface) with large numbers of PVCs (100s to 1000s). This problem occurs when you attempt to configure large numbers of PVCs on the main interface (or multipoint subinterfaces) with static maps on each PVC.
Workaround: Do not configure more than 500 PVCs on a single OC-12 ATM line card or more than 900 PVCs on a Cisco 10000 series ESR.
After you enter the show controller command, occasionally an alarm LED appears as active even though no alarms are indicated
Workaround: Perform a shut/no shut configuration on the SONET controller. For example:conf tcontroller sonet 7/0/0shutno shutend
If you reload a Cisco 10000 series ESR, some initialization messages are logged to the console before the startup-config is loaded. These initialization messages are transitional and may report an incorrect state, especially for the FastEthernet interface.00:00:15: Downloading Microcode: file=system:pxf/ucode_file, version=2.0(21.4), description=Nightly Build Software created Wed 13-Sep-00 00:3800:00:21: %LINK-3-UPDOWN: Interface Ethernet0/0/0, changed state to up00:00:21: %LINK-5-CHANGED: Interface FastEthernet0/0/0, changed state to reset00:00:23: %LINEPROTO-5-UPDOWN: Line protocol on Interface Ethernet0/0/0, changed state to up0:00:23: %LINEPROTO-5-UPDOWN: Line protocol on Interface FastEthernet0/0/0, changed state to down
These messages do not appear in the buffered log.
Workaround: Ignore these messages.
The show atm pvc command displays "Unexpected QoS type" for its traffic parameters. This occurs when a PVC was previously configured with only an ATM vc-class, and then the vc-class was subsequently deleted.
For example:sw-apollo-3(config)#vc-class atm testsw-apollo-3(config-vc-class)#vbr-nrt 1000 1000 10sw-apollo-3(config-vc-class)#exitsw-apollo-3(config)#int atm 3/0/0sw-apollo-3(config-if)#pvc 200sw-apollo-3(config-if-atm-vc)#class-vc testsw-apollo-3(config-if-atm-vc)#endsw-apollo-3#sh atm vcVCD / Peak Avg/Min BurstInterface Name VPI VCI Type Encaps Kbps Kbps Cells Sts3/0/0 1 0 200 PVC SNAP 1000 1000 10 UPsw-apollo-3#Now delete the vc-class :sw-apollo-3#conf tsw-apollo-3(config)#no vc-class atm testsw-apollo-3(config)#endsw-apollo-3#sh atm vcVCD / Peak Avg/Min BurstInterface Name VPI VCI Type Encaps Kbps Kbps Cells Sts3/0/0 1 0 200 PVC SNAP %Unexpected qos type UP
Workaround: Configure the vc directly using conventional means (non ATM vc-classes), or remove the vc and re-create it with a new ATM vc-class.
The show interface output occasionally displays an extremely large number of configured VCs which do not really exist.
Workaround: There is currently no workaround.
When a segment on a MPLS traffic engineered path is disabled, the PXF engine reloads, temporarily causing all forwarding to stop.
Workaround: There is currently no workaround.
With multiple PVP tunnels, if the aggregate traffic received by one or more of the PVPs is heavily oversubscribed (starting at about 110% of the tunnel's PCR rate), the traffic on companion PVP tunnels on that interface may experience throughput that is lower than expected.
Workaround: There is currently no workaround.
When you boot the Cisco 10000 series ESR, the system may display the following messages:*Oct 17 12:32:48.287: %SNMP-3-TRAPBLOCK: Attempt to generate SNMP trap from a process with blocking disabled-Traceback= 60565064 606A6B34 60678238 60678438 6067AD88 6067AF30 602FCBDC 6024817C 60248168
Workaround: Ignore the messages.
If incoming multicast packets match an input access list that has the log option enabled, the output of the show log command and show access-list commands display double the number of matches.
Workaround: There is currently no workaround.
Line Protocol on one or two T1s may not come up when you perform a reload with a large configuration (for example, 1008 T1s with PPP encap or 504 MLPPPs).
Workaround: Reload the line card using the command hw slot slot_number reset.
When a redundant power supply is removed or a line card is OIRed, SNMP traps are generated by the syslog mib. There is a request to generate these traps using the env, mon, and entity MIBs respectively.
Workaround: Filter the SNMP traps using the syslog MIB.
When a serial interface is configured to be part of a MPLS/VPN, if you enter the no channelized command on the T3 controller, this clears the interface. However, the sh ip vrf vrf_name continues to show the interface as part of the vrf.
Workaround: The only way to eliminate unwanted interfaces in the vrf table is to reload the box.
In the unlikely event of a total failure of the cooling fan tray, or any other scenario resulting in high-temperature operation, the Cisco 10000 series ESR continues running, and does not power off.
Workaround: If you observe fan failure or over-temperature alarms or log messages, immediately power off the chassis until the problem is corrected.
Ping traffic does not resume after you switch from an explicit path to a dynamic path.
Workaround: There is currently no workaround.
When MPLS TE is configured and the logging console is turned on, the following error message appears repeatedly in the window:"00:58:10: %TFIB-7-SCANSABORTED: TFIB scan not completing. MAC string updated."
Workaround: Leave the logging console turned off.
ISIS adjacencies become recalculated with 65 to 85 MB of TCP traffic to the router.
Workaround: Because this problem is caused by hackers, we recommend that you use access lists to block out hackers. Access lists prevent packets from punting to the RP and taking down the router.
A Cisco 10000 series ESR router running Cisco IOS Release 12.0(10)SL may experience a buffer leak when interfaces are down (but not administratively down).
Workaround: Administratively shut down the interfaces.
If you request deletion of a file from flash storage, the flash file delete function may choose an incorrect default device. The incorrect default used is slot0:.
Workaround: When you specify the filename, prefix the filename with disk0:.
During the reloading process, the match input-interface Serial3/0/0/1:0 configuration statement is not recognized and disappears from the configuration files after the Cisco 10000 series ESR is reloaded.
Workaround: Reenter the match input-interface Serial3/0/0/1:0 command.
PVCs in the down state can still pass traffic. When a PVP is created with associated F4 OAM VCs, and those F4 OAM VCs do not appear (for instance, because there is no VP at the far end or the VP at the far end did not create F4 OAM VCs), traffic can still be passed on the PVCs associated with the PVP in question. When the F4 OAM loopback cells are not returned, Cisco IOS software declares all PVP associated PVCs to be down. IOS does not, however, notify the forwarding engine or the line card. This allows traffic routed over the PVCs in question to pass.
Workaround: There is currently no workaround.
When the ACL is downloaded from the tftp server, the CPU advances to 100% utilization and several line cards lost IPC with the PRE and are reset.
Workaround: Do not configure all 8000 lines of ACL. Split the ACL into several smaller ACLs and download them separately.
In a chassis using TACACS security and running redundant PREs, you can access the console while the secondary PRE is cutting over to primary PRE. If no action is taken on the console for the length of the session timeout period, TACACS engages on the console. If the user does access the console during the cutover, the user enters exec mode (not enable mode).
Workaround: To help control security, set a short session timeout on the console port, and keep tight control of the enable password.
MALLOCFAIL with multicast traffic if a high rate of multicast traffic is sent out before multicast routing entries are updated.
Workaround: There is currently no workaround. After the routing entries are updated, this problem disappears.
TFIB table failure.
Workaround: There is currently no workaround. However, the table eventually updates.
Sometimes a traceback message is generated during an RPR+ switch over to the new primary PRE. A message similar to the following appears:00:03:07: %IPC-5-INVALID: Sequence Structure port index=0x3-Traceback= 60321EC0 60322868 60806A54 603348C8 60359924 60025B94 602828CC 602828B8
Workaround: This message is harmless. Ignore the message.
On rare occasions, if a large number of ds0 interfaces are configured on a CT3 line card, spurious memory error messages may appear.
Workaround: There is currently no workaround.
On rare occasions in which relatively high rates of bursty traffic are received on the OC-12 ATM line card, some packets may be dropped but not counted by the software.
Workaround: There is currently no workaround.
If you use snmpwalk or other similar tool to display the value of the different objects associated with a Cisco 10000 series ESR, you can see that when an unchannelized DS3 controller has been created in a ChOC-12 line card, the configuration values of the DS3 MIB are not correct. If subsequent configuration commands are issued, the values displayed are correct. This problem probably exists in a channelized STM-1 line card as well, when in unchannelized DS3 mode.
Workaround: Rely on the outcome of the show controller t3 and show interface serial commands.
Verilink-hibit mode does not work on the Cisco 10000 series ESR with ChOC-12 line cards whose paths are configured in unchannelized DS3 mode. When the Verilink-hibit mode is chosen by the network administrator, Verilink-lowbit mode is programmed in the hardware instead.
Workaround: There is currently no workaround. You must use Verilink-lowbit mode.
The message Bad file magic number - cannot load bootflash appears.
Workaround: Perform the following:
a. copy bootflash:<file> to disk0:<file>
b. delete bootflash:<file> and squeeze bootflash:
c. copy disk0:<file> bootflash:<file>
At the end of the line in the show run command output, 0.0.0.0 is appended randomly.
Workaround: Make sure that 0.0.0.0 is not in the running-config when saving it and then reusing it.
ChOC-12 DS3 subrate does not work in Kentrox mode at full bandwidth.
Workaround: Set the ChOC-12 interface to Digital Link mode and full bandwidth (no dsu bandwidth). This works the same as the Kentrox CSU/DSU when set to full bandwidth, and will work with scrambling enabled or disabled (set the same value at both ends).
With 500 Frame Relay interfaces on CT3 running IP Multicast, multicast packets get punted to the RP causing IPC OIR on the CT3. This causes the line protocol on the router connected to the Cisco 10000 series ESR to go down (and remain down) on some interfaces. The interface stats show no traffic over the affected interface. On the Cisco 10000 series ESR the Frame Relay PVC corresponding to it shows as Deleted.
Workaround: Perform a shut/no shut on the affected interface, or a hw-module slot reset on the line card to bring the line protocol back up.
In some cases, ATM counters display incorrect packet input values after receiving packets from several locations (for example, the line card, IOS, and the PXF forwarding engine).
Workaround: There is currently no workaround.
If you reload microcode, and you have changed IP addresses on interfaces just before you reload, traffic may be forwarded to an incorrect interface.
Workaround: Use the shutdown command to shutdown the interface experiencing the problem, and then reactivate it by using the no shutdown command.
When the Cisco 10000 series ESR is configured for 802.1q VLANs, the output of the show vlans command reports values that are higher than they should be, for the following parameters:
•gigabit Ethernet received packets
•gigabit Ethernet received bytes
•VLAN received packets
Workaround: There is currently no workaround.
If you perform a reload, the values for the transmitted and received output of the show vlans command indicates, incorrectly, that those values incremented.
Workaround: There is currently no workaround.
When the destination IP address of an incoming 802.1q packet matches one of the IP addresses of the router, the output of the show vlans command for 802.1q packets increments two times. Ping request packets, however, are always counted correctly regardless of destination.
Workaround: There is currently no workaround.
If you configure fair queueing on a frame relay interface with a large number of PVCs, and the traffic exceeds the link rate, several PVCs may experience a greater number of drops than other PVCs on that interface.
Workaround: There is currently no workaround.
When the interface on the remote end is set to be administratively down, and you are attempting to bring up the PPP protocol, the status of the interface alternate between down and up until the PPP protocol is up.
Workaround: There is currently no workaround.
If you configure 998 VPNs over VLAN, and you configure over 146 BGP routes per VPN, the BGP neighbor may start flapping.
Workaround: There is no workaround, but the problem is less likely to occur if you configure fewer than 146 BGP routes per VPN.
If you configure more than 100 BGP routes per VPN, and there are more than 200 VPNs configured on the system, CEF may not function properly after redistributing.
Workaround: Reduce the number of BGP routes per VPN to 100 or less.
If you enable multicast replication with an MLP bundle as the source, and the MLP broadcaster may exhibit behavior that is not compliant with MLP standards, then replication may not occur for all interfaces.
Workaround: If replication does not occur on all interfaces, reload the microcode.
Resolved Problems in Cisco IOS Release 12.0(17)SL
This section lists problems that are resolved in Cisco IOS Release 12.0(17)SL. For a list of problems that were resolved in previous Cisco IOS Releases, refer to the release notes for those particular versions.
When you enter the hw-module slot_number reset command, and the logging console is configured to informational, the event sequence no longer appears in a different order than that shown by the reload command.
CSCdr52081 and CSCdj94209
Previously, the PRE could crash if you repeatedly changed a port back and forth from channelized to unchannelized. This no longer occurs.
Previously, large multicast groups could cause CPU hog issues with PIM. This has been fixed.
When older CT3 line cards were powered on, with live DS3 signals present at the receive BNC connector, the receive line interface device on the board could possibly lock up, preventing the controller from running. This no longer occurs.
If the interface between a PE (PE1) and CE router went down, MPLS labels would disappear at the far end provider edge peer (PE2) MPLS interface. This has been fixed.
If you entered the clear ip mroute command on a system with large multicast groups, CPU hog issues could arise that caused problems of moderate severity (such as losing keepalives). This no longer occurs.
Previously, if you performed an SNMP walk or viewed entries in the if table, cef-layer internal interfaces appeared in the interface table.
Previously, the Kentrox DS3 subrate mode did not work when you set it to full bandwidth (45.2 Mbps on Kentrox CSU, 44210 kbps on a Cisco 10000 series ESR).
If you issued the dir or show slot0: or show slot1: command, the router reported Open device slot0 failed (Device not ready). This has been fixed.
If large OIDs (1024.1 fields) were sent to the router, the Cisco 10000 series ESR stopped responding. This no longer occurs.
Previously, if you deleted a T1/E1, IP routes associated with subinterfaces were not removed.
On a Cisco 10000 series ESR system with channelized OC-12 line cards, the output of the show controllers command is now complete and correct.
When a large number of VBR-nrt VCs are configured (200 and above) and the link transitions DOWN, the host software running on the OC-12 ATM line card no longer takes a SW Watchdog timeout, forcing the line card firmware to reload.
If you perform OIR on a line card configured for 768 PPP sessions with traffic running on all interfaces, interfaces no longer fail to come up. The show interface command now displays the correct IPCP state.
On rare occasions, line cards would not be recognized when you performed an OIR of multiple cards on a new system, or in a system in which the configuration was erased (for example, using write erase). This has been fixed.
If an access-list with logging option enabled is attached to an interface, and you send traffic through the interface, the interfaces no longer go down.
Under circumstances where ATM VCs are created and deleted on a regular basis, the OC-12 ATM segmenter firmware will no longer transition to a state in which it drops some packets without counting them in a data stream where packet sizes alternate from small to large.
Previously, when a TU-AIS was received at a particular TU in TUG3#3, the next TU at the T1 or E1 level contained data corruption. This no longer occurs.
If you remove an APS configuration for a channelized OC-12 line card, and then issue the show controllers sonet high_slot_number command, or the show controllers sonet command, the Cisco 10000 series ESR no longer crashes.
Other Resolved Caveats
This section includes caveats listed in previous release notes that are listed as resolved because they are unreproducible or do not affect the behavior of the Cisco 10000 series ESR. In the event a caveat listed in this section causes problems, please contact Cisco customer service.
For a list of unreproducible caveats in previous Cisco IOS Releases, refer to the release notes for those particular releases.
During periods of heavy traffic (approaching interface line rate), some interfaces experienced inconsistent performance between interfaces of the same type.
The number of VPNs that could be created on gigabit Ethernet subinterfaces was limited to under 100.
When the encapsulation mode was changed from PPP to HDLC or vice-versa, the system dropped about 3 of the next 10 packets transmitted. After that, the packets were transmitted normally.
When a ChOC-12 line card was reconfigured from a channelized T3 configuration to an unchannelized T3 configuration or vice-versa, the initial packets were not forwarded.
If you sent a large number of small packets in large multicast groups, this could cause certain debug messages to appear on the console.
Occasionally, after you reloaded routers (with background traffic load equal to no_drop rate), the throughput was 3 to 400 pps below the expected rate.
On rare occasions, after a single reload while under load, the Gigabit Ethernet line card was up, but dropped nearly all packets on the output queue.
If some interfaces flapped continuously in a Frame-Relay environment, the interface statistics reported input errors (overruns) on the flapping interfaces.
Following a reload of the Cisco IOS software, the Gigabit Ethernet interface did not always come back up. The interface remained in the "GigabitEthernet1/0/0 is down, line protocol is down" state.
During a reload, if the router continuously received IP packets, CPUHOG messages may appeared in the log, and the router may took longer to come up.
After you reloaded line cards under background traffic load, one or more interfaces would not come up.
If you issued a write erase command on the primary PRE followed by an erase sec-nvram: command, and then reloaded both PREs simultaneously, some line cards would not be recognized correctly on reboot.
The router stopped responding after several hours of receiving multicast traffic over 500 CT3 ds0 Frame Relay interfaces, at a rate of 10 pps of 260-byte packets.
The ip address negotiate command sent dhcp requests out to all serial line interfaces.
In some test instances, Frame Relay interfaces did not correctly join a multicast group when it should have. The result is that multicast packets destined for those interfaces will be punted to the route processor. If enough packets were received, the CPU usages on the route processor to run at a high usage.
On rare occasions, when a large number of ds0 interfaces was configured on a CT3 line card, buffer with corrupt pool pointer error messages would appear.
Under rare conditions in which scripts of VC creates and VC deletes were executed in turn, some VBR-nrt VCs were not created.
Obtaining Documentation
The following sections provide sources for obtaining documentation from Cisco Systems.
World Wide Web
You can access the most current Cisco documentation on the World Wide Web at the following sites:
Documentation CD-ROM
Cisco documentation and additional literature are available in a CD-ROM package, which ships with your product. The Documentation CD-ROM is updated monthly and may be more current than printed documentation. The CD-ROM package is available as a single unit or as an annual subscription.
Ordering Documentation
Cisco documentation is available in the following ways:
•Registered Cisco Direct Customers can order Cisco Product documentation from the Networking Products MarketPlace:
•Registered Cisco.com users can order the Documentation CD-ROM through the online Subscription Store:
•Nonregistered Cisco.com users can order documentation through a local account representative by calling Cisco corporate headquarters (California, USA) at 408 526-7208 or, in North America, by calling 800 553-NETS (6387).
Documentation Feedback
If you are reading Cisco product documentation on the World Wide Web, you can submit technical comments electronically. Click Feedback in the toolbar and select Documentation. After you complete the form, click Submit to send it to Cisco.
You can e-mail your comments to firstname.lastname@example.com.
To submit your comments by mail, use the response card behind the front cover of your document, or write to the following address:
Attn. Document Resource Connection
Cisco Systems, Inc.
170 West Tasman Drive
San Jose, CA 95134-9883
We appreciate your comments.
Obtaining Technical Assistance
Cisco provides Cisco.com as a starting point for all technical assistance. Customers and partners can obtain documentation, troubleshooting tips, and sample configurations from online tools. For Cisco.com registered users, additional troubleshooting tools are available from the TAC website.
Cisco.com is the foundation of a suite of interactive, networked services that provides immediate, open access to Cisco information and resources at anytime, from anywhere in the world. This highly integrated Internet application is a powerful, easy-to-use tool for doing business with Cisco.
Cisco.com provides a broad range of features and services to help customers and partners streamline business processes and improve productivity. Through Cisco.com, you can find information about Cisco and our networking solutions, services, and programs. In addition, you can resolve technical issues with online technical support, download and test software packages, and order Cisco learning materials and merchandise. Valuable online skill assessment, training, and certification programs are also available.
Customers and partners can self-register on Cisco.com to obtain additional personalized information and services. Registered users can order products, check on the status of an order, access technical support, and view benefits specific to their relationships with Cisco.
To access Cisco.com, go to the following website:
Technical Assistance Center
The Cisco TAC website is available to all customers who need technical assistance with a Cisco product or technology that is under warranty or covered by a maintenance contract.
Contacting TAC by Using the Cisco TAC Website
If you have a priority level 3 (P3) or priority level 4 (P4) problem, contact TAC by going to the TAC website:
P3 and P4 level problems are defined as follows:
•P3—Your network performance is degraded. Network functionality is noticeably impaired, but most business operations continue.
•P4—You need information or assistance on Cisco product capabilities, product installation, or basic product configuration.
In each of the above cases, use the Cisco TAC website to quickly find answers to your questions.
To register for Cisco.com, go to the following website:
If you cannot resolve your technical issue by using the TAC online resources, Cisco.com registered users can open a case online by using the TAC Case Open tool at the following website:
Contacting TAC by Telephone
If you have a priority level 1 (P1) or priority level 2 (P2) problem, contact TAC by telephone and immediately open a case. To obtain a directory of toll-free numbers for your country, go to the following website:
P1 and P2 level problems are defined as follows:
•P1—Your production network is down, causing a critical impact to business operations if service is not restored quickly. No workaround is available.
•P2—Your production network is severely degraded, affecting significant aspects of your business operations. No workaround is available.
AccessPath, AtmDirector, Browse with Me, CCIP, CCSI, CD-PAC, CiscoLink, the Cisco Powered Network logo, Cisco Systems Networking Academy, the Cisco Systems Networking Academy logo, Cisco Unity, Fast Step, Follow Me Browsing, FormShare, FrameShare, IGX, Internet Quotient, IP/VC, iQ Breakthrough, iQ Expertise, iQ FastTrack, the iQ Logo, iQ Net Readiness Scorecard, MGX, the Networkers logo, ScriptBuilder, ScriptShare, SMARTnet, TransPath, Voice LAN, Wavelength Router, and WebViewer are trademarks of Cisco Systems, Inc.; Changing the Way We Work, Live, Play, and Learn, and Discover All That's Possible are service marks of Cisco Systems, Inc.; and Aironet, ASIST, BPX, Catalyst, CCDA, CCDP, CCIE, CCNA, CCNP, Cisco, the Cisco Certified Internetwork Expert logo, Cisco IOS, the Cisco IOS logo, Cisco Press, Cisco Systems, Cisco Systems Capital, the Cisco Systems logo, Empowering the Internet Generation, Enterprise/Solver, EtherChannel, EtherSwitch, FastHub, FastSwitch, GigaStack, IOS, IP/TV, LightStream, MICA, Network Registrar, Packet, PIX, Post-Routing, Pre-Routing, RateMUX, Registrar, SlideCast, StrataView Plus, Stratm, SwitchProbe, TeleRouter, and VCO are registered trademarks of Cisco Systems, Inc. or its affiliates in the U.S. and certain other countries.
All other trademarks mentioned in this document or Web site are the property of their respective owners. The use of the word partner does not imply a partnership relationship between Cisco and any other company. (0110R)
Copyright © 2001, Cisco Systems, Inc.
All rights reserved.


text:
Geneviève Metson is a doctoral student at Montreal's McGill University who is studying an interesting offshoot of agricultural sustainability: Phosphorus.
That's right. Phosphorus. Not exactly top of mind when it comes to potential crises in food production.
However, as Metson's research statement explains, "Phosphorus is a scarce resource essential to food production, but in too large quantities can also cause pollution in water bodies. More sustainable phosphorus management is essential for food security and pollution abatement."
No argument here.
For the most part, phosphorus is considered a non-renewable resource, since its principal commercial source in modern times is apatite, phosphate-containing rock (in previous centuries, phosphorus was primarily obtained from animal bones or phosphorus-rich guano). Although significant deposits of apatite are found in Florida, Tennessee, Idaho and Utah, fully one-half of the world's reserves of phosphorus are located in Arab nations.
That makes sustainable phosphorus management an important strategic priority and Metson's research something more than an intriguing thesis topic.
But here's the kicker: She's focused on finding out how much of the phosphorus that's mined for use as a nutritional additive in animal rations or for commercial fertilizer to grow feed crops ends up directed toward meat production.
That fits right in with the current fad of calculating the carbon footprint and the resource consumption required to produce a pound of beef, pork or chicken. Those charts provide a visual snapshot of the land area, water use and energy consumption—allegedly—needed to put a hamburger or a chicken breast on somebody's dinner plate. (Here is an example of one such infograph, developed by Dr. Judith Capper, a dairy scientist who has done extensive research on sustainable livestock production: www.npr.org/blogs/thesalt/2012/06/27/155527365/visualizing-a-nation-of-meat-eaters)
It's all about the footprint
Not surprisingly, Metson determined that meat production is one of the most prominent food sectors dependent on phosphorus. Thus, as she argued in a communication published in Environmental Research Letters, meat's phosphorus footprint is reason enough to eat less of it, given that phosphorous is a finite resource.
"Changes we can make in our diet to decrease the demand for mined phosphorus can also decrease the use of other resources," Metson told National Public Radio. "We need to manage our food system in an equitable and sustainable way."
To be sure, extracting phosphates from deposits around the world has helped fuel a major increase in global food production. Phosphate production in 2012 was 220 million tons, up from 165 million tons in 1994.
But is phosphorus availability really a serious concern? Not according to the Alabama-based International Fertilizer Development Center, an organization dedicated to improving food security, agricultural productivity and economic development through farm efficiency.
I have a lot of respect for IFDC, an organization that gets involved with controversial issues but maintains its focus on initiatives that move the needle. For example: Its priorities include projects to reduce food waste, improve access to modern farming technologies and fertilizer, expand sustainable energy production and improve market access for farm products grown in developing countries.
As for phosphorus, Steven Van Kauwenbergh, the principal scientist and leader of IFDC's Phosphate Research and Resources Initiative, stated that, "Phosphorus is pretty far down the list of things we're going to suddenly run out of."
A 2010 IFDC report titled, "World Phosphate Rock Reserves and Resources," projected that even with current rates of production, phosphate rock reserves should last another 300 to 400 years.
Van Kauwenbergh also noted that IFDC's approach to improving farm productivity, particularly in areas where improper management or monoculture cropping has depleted the soil, includes a combination of organic soil amendments and use of inorganic fertilizers to rebuild fertility. It's not just about adding nitrogen (derived principally from natural gas) or phosphorus; soil fertility also depends on a proper balance of organic matter to promote water retention and root development.
Metson, however, argued that the growth of phosphate usage worldwide is unsustainable, noting in her letter that, "[The] global per capita phosphorus footprint has increased 38% over the last 50 years."
In making the point that meat-eating corresponds with phosphorus use, she noted that Luxembourg—considered the world's heaviest meat-eating country—consumes 16.8 pounds of phosphorus per person, while The Congo's per capita use is less than one pound a year. (Interestingly, though, Canada—certainly a country that's hardly adverse to meat eating—has seen its per capita use of phosphorus actually decrease since the 1960s.)
So while it's difficult to make conclusive judgments about phosphorus and meat production, it seems safe to say that the world will face critical shortages of oil—a far greater concern for agriculture—much sooner than any imaginable phosphorus crisis.
Phosphorus is something to think about, but nothing to lose sleep over.
The opinions expressed in this commentary are solely those of Dan Murphy, a veteran food-industry journalist and commentator.

subset: commoncrawl


text:
NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Sunday, September 24, 2017
Healthy Weight Center
Gaining Weight for Health
I am a 22 yr. old woman and I weigh about 103 lbs and am 5ft. 8in. I can`t seem to gain weight. I try and eat a lot and do the opposite of people who try to lose weight. I try not to exercise too vigorously. I also have 2 small children and I gained 40 lbs with each and lost it immediately after having each one. What can I do to gain weight? Could it be a thyroid problem or something or just a fast metabolism?
Thanks for your question. At 5'8, your weight of 103# is certainly on the light side. Your "ideal" weight (according to height/weight charts) is between 124-154. However, if you have always been thin, you may never weigh that much. Your body's set point is an internal cue to keep your body weight fairly stable. So, gaining weight may be difficult for you.
It is common to gain more weight than what is considered "normal" when you are thin to start with. Average weight gain recommendations for normal weight women are 25-30#. For someone thin to start with, a gain of over 30 lbs may be beneficial to you and your baby.
When you say you are "doing the opposite of what people do to lose weight", I am assuming you are eating high calorie or high fat foods. In order to gain weight, you should try to eat 3 meals per day, plus in between meal snacks. You should expect to feel full, but don't make yourself sick!
Your calorie intake for weight gain should be approximately 1800-2200 calories per day. This can easily be accomplished by choosing foods from the Daily Food Guide Pyramid. Try to eat at 6-11 servings of bread, cereal, grains or pasta, 2-4 servings of fruit or juice, 3-5 servings of vegetables, 2-3 glasses of milk or yogurt and 2-3 servings of meat per day. Increasing your juice, starch and milk servings will increase calories, but not necessarily fat. Of course, this depends on the type of dairy products you choose. Choose 1% or skim milk when possible, and add dry powdered milk to it to increase calories and protein, but not fat.
High fat, high sugar foods will also increase your caloric intake, and hopefully your weight. However, OVER consumption of these foods may also increase your risk of heart disease, cancer or cavities (over time). Obviously, you don't want to be really strict with yourself, but keep in mind that these foods should be eaten IN ADDITION to foods from the Food Guide Pyramid (not IN PLACE of them).
A registered dietitian can assist you in meal planning and snacking. A dietitian can also assess your exercise habits to make sure you are not burning up too many calories, which may inhibit weight gain.
Speaking of exercise, strength or resistance training would be beneficial to you so that you gain muscle, and not just fat. Keep in mind, weight gain is like weight loss; it does not happen overnight. If you try these suggestions, and see no improvement in the next few weeks, see your physician. I am not trained to diagnose thyroid conditions or metabolic disorders.
I hope this information helped you. Good Luck!
Lisa Cicciarello Andrews, MEd, RD, LD
Adjunct Faculty
University of Cincinnati


text:
Outpatient Induction Chemotherapy in Treating Patients With Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome
This study is currently recruiting participants.
Verified July 2017 by University of Washington
University of Washington
National Cancer Institute (NCI)
Information provided by (Responsible Party):
University of Washington
ClinicalTrials.gov Identifier:
First received: March 6, 2013
Last updated: July 3, 2017
Last verified: July 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This pilot clinical trial studies the feasibility of having induction chemotherapy in an outpatient setting. Patients with acute leukemia (AML) or advanced myelodysplastic syndrome (MDS), at least 18 years of age will be examined. Treating eligible patients with induction chemotherapy in an outpatient setting may save in healthcare cost and improve a patients' quality of life.
|Adult Acute Myeloid Leukemia Adult Myelodysplastic Syndrome
|Drug: Chemotherapy
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Feasibility of Outpatient Induction Chemotherapy for Adult Patients With Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome
Resource links provided by NLM:
Genetics Home Reference related topics: core binding factor acute myeloid leukemia cytogenetically normal acute myeloid leukemia familial acute myeloid leukemia with mutated CEBPA
MedlinePlus related topics: Acute Myeloid Leukemia Leukemia Myelodysplastic Syndromes
Genetic and Rare Diseases Information Center resources: Myeloid Leukemia Acute Myeloid Leukemia Acute Non Lymphoblastic Leukemia Myelodysplastic SyndromesU.S. FDA Resources
Further study details as provided by University of Washington:
Primary Outcome Measures:
- Rate of hospital admission [ Time Frame: During the 4-7 days of outpatient chemotherapy ]
- TRM rate [ Time Frame: During the 14 days after beginning outpatient treatment ]
|Estimated Enrollment:
|Actual Study Start Date:
|May 21, 2013
|Estimated Primary Completion Date:
|April 1, 2018 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment (chemotherapy)
Patients receive outpatient induction chemotherapy.
Drug: Chemotherapy
Receive outpatient induction chemotherapy
Other Names:
Detailed Description:
I. Assess the feasibility of outpatient induction therapy for acute myeloid leukemia (AML) or advanced myelodysplastic syndrome (MDS) by examining whether > 50% of patients treated as outpatients can complete chemotherapy without being admitted to hospital or < 5% of patients die within 14 days of beginning outpatient chemotherapy.
Patients receive outpatient induction chemotherapy.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Signed written informed consent
- The signed informed consent
- The benefits/risks of the induction chemotherapy regimen will be reviewed, and a second consent may be necessary if the regimen will be administered according to a separate protocol
- AML (acute promyelocytic leukemia [APL] excepted) or high-risk MDS (10-19% blasts in marrow by morphology or flow cytometry or blood)
- Treatment-related mortality (TRM) score < 9.21 corresponding to a TRM rate of 3% when chemotherapy of similar intensity as proposed here is administered to inpatients
- Blast count =< 10,000
- Fibrinogen > 200
- Afebrile with clear chest imaging and no signs of active viral, bacterial, fungal infection unless determined to be, at the discretion of the investigator, not clinically significant in the context of this study
- Adequate cardiac function as demonstrated by left ventricular ejection fraction (LVEF) of 45% or greater, by multiple gated acquisition (MUGA) or echocardiogram; no ongoing cardiac issues such as uncontrolled arrhythmias or unstable angina or congestive heart failure
- Patient must have an outpatient caregiver available
- Patient must live within 30 minutes of the treating physician's office during outpatient treatment
- Patient must be willing to return to the treating physician's office for outpatient follow-up once outpatient treatment is completed
Logistical requirements:
- Space available in infusion room
- Outpatient infusion pump available if continuous infusion required
- Case discussed with infusion room nursing staff
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01807091
Please refer to this study by its ClinicalTrials.gov identifier: NCT01807091
|United States, Montana
|Bozeman Deaconess Hospital
|Bozeman, Montana, United States, 59715
|Contact: Jack O. Hensold 406-585-5070 firstname.lastname@example.com
|Principal Investigator: Jack O. Hensold
|United States, Washington
|Kadlec Clinic Hematology and Oncology
|Kennewick, Washington, United States, 99336
|Contact: Thomas A. Rado 509-783-0144 email@example.com
|Principal Investigator: Thomas A. Rado
|EvergreenHealth Medical Center
|Kirkland, Washington, United States, 98033
|Contact: Aimee D. Kohn 425-899-3953 firstname.lastname@example.com
|Principal Investigator: Aimee D. Kohn
|Skagit Valley Hospital
|Mount Vernon, Washington, United States, 98274
|Contact: Kiarash Kojouri 360-428-2146 email@example.com
|Principal Investigator: Kiarash Kojouri
|Olympic Medical Center
|Port Angeles, Washington, United States, 98362
|Contact: Thomas D. Kummet 360-683-9895 firstname.lastname@example.com
|Principal Investigator: Thomas D. Kummet
|Group Health Cooperative
|Redmond, Washington, United States, 98052
|Contact: Eric Y. Chen 425-502-3690 email@example.com
|Principal Investigator: Eric Y. Chen
|Fred Hutch/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Contact: Pamela S. Becker 206-616-1589 email@example.com
|Principal Investigator: Pamela S. Becker
|Multicare Health System
|Tacoma, Washington, United States, 98415
|Contact: John A. Keech 253-403-1677 email@example.com
|Principal Investigator: John A. Keech
|Wenatchee Valley Hospital and Clinics
|Wenatchee, Washington, United States, 98801
|Contact: Mitchell A. Garrison 509-663-8711 firstname.lastname@example.com
|Principal Investigator: Mitchell A. Garrison
Sponsors and Collaborators
University of Washington
National Cancer Institute (NCI)
|Principal Investigator:
|Pamela Becker
|Fred Hutch/University of Washington Cancer Consortium
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|University of Washington
|ClinicalTrials.gov Identifier:
|NCT01807091 History of Changes
|Other Study ID Numbers:
NCI-2013-00483 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
7910 ( Other Identifier: Fred Hutch/University of Washington Cancer Consortium )
P30CA015704 ( U.S. NIH Grant/Contract )
|Study First Received:
|March 6, 2013
|Last Updated:
|July 3, 2017
Additional relevant MeSH terms:
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Myelodysplastic Syndromes
Pathologic Processes
Neoplasms by Histologic Type
Bone Marrow Diseases
Hematologic Diseases
Precancerous Conditions
ClinicalTrials.gov processed this record on September 21, 2017


text:
Obey, featuring dresses, tops, denim, jewelry, and accessories, was founded on the ideals and designs of Shepard Fairey. The artist's influences include the do-it-yourself counterculture, rooted in the punk and skate lifestyles, as well as pop culture, commercial art, and political advertising. Founded in 2001, Obey began as an extension of Fairey's work and has since grown into a massively popular brand that caters to hipster street culture. Obey's unique styles often reference military suiting, everyday workwear, and inspirational cultural movements. With youthful and energetic styles in fresh modern fits, it's no wonder Obey is a globally sought-after name in streetwear apparel.
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text:
|Date / Time
|Monday September 04, 2017 @05:26PM
|Google Conducted Hollywood 'Interventions' To Change Look of Computer Scientists
|Friday July 21, 2017 @11:39PM
|Drupal Developers Still Rebelling Against Drupal Leadership
|Monday February 22, 2016 @08:38PM
|Scientists Ponder the Prospect of Contagious Cancer
|Monday August 31, 2015 @12:16AM
|Brain Cancer Claims Horror Maestro Wes Craven At 76
|Thursday July 09, 2015 @08:36AM
|Robot Performs Prostate Surgery Inside an MRI
|Thursday July 02, 2015 @08:17AM
|Creating Bacterial "Fight Clubs" To Discover New Drugs
|Thursday June 04, 2015 @08:47AM
|How Overhauling IT Was a Life-Saver For the American Cancer Society
|Friday April 24, 2015 @10:52AM
|MIT Developing AI To Better Diagnose Cancer
|Thursday April 23, 2015 @09:02AM
|Wellness App Author Lied About Cancer Diagnosis
|Monday February 02, 2015 @12:32PM
|Telomere-Lengthening Procedure Turns Clock Back Years In Human Cells
|Tuesday August 12, 2014 @11:37AM
|Injecting Liquid Metal Into Blood Vessels Could Help Kill Tumors
|Monday July 28, 2014 @09:40PM
|UK Team Claims Breakthrough In Universal Cancer Test
|Saturday July 26, 2014 @07:54PM
|Two South African Cancer Patients Receive 3D Printed Titanium Jaw Implants
|Friday July 25, 2014 @06:10PM
|Google Looking To Define a Healthy Human
|Tuesday July 22, 2014 @08:29AM
|Taking Great Ideas From the Lab To the Fab
|Sunday April 06, 2014 @09:33AM
|To Reduce the Health Risk of Barbecuing Meat, Just Add Beer
|Thursday March 20, 2014 @10:18AM
|IBM's Watson To Be Used For Cancer Treatment
|Tuesday March 18, 2014 @08:30AM
|Famous Breast Cancer Gene Could Affect Brain Growth
|Thursday February 13, 2014 @09:27AM
|11-Year UK Study Reports No Health Danger From Mobile Phone Transmissions
|Tuesday February 04, 2014 @09:00AM
|Ultrasound Technique Provides a New Radiation Free Way To Visualize Tumors
|Monday December 30, 2013 @02:46AM
|Parents' Campaign Leads To Wi-Fi Ban In New Zealand School
|Monday September 16, 2013 @05:45PM
|Depletion of 'traitor' immune cells slows cancer growth in mice
|Monday August 19, 2013 @09:02PM
|GM Rice Passes Unexpected Benefits To Weeds
|Sunday August 11, 2013 @10:11PM
|Dogs Trained To Sniff Out Ovarian Cancer
|Sunday June 23, 2013 @11:51PM
|New Links Found between Bacteria and Cancer
|Friday June 21, 2013 @08:25PM
|Citrix Founder and Key OS/2 Player Ed Iacobucci Dead At 59
|Thursday April 04, 2013 @05:32PM
|Film Critic Roger Ebert Dead at 70 Of Cancer
|Wednesday April 03, 2013 @09:06AM
|Iain Banks: Extremely Ill With Cancer
|Monday April 01, 2013 @08:37PM
|Indian Supreme Court Denies Novartis Cancer Drug Patent
|Monday April 01, 2013 @10:17AM
|Novartis denied cancer drug patent in landmark Indian case
|Friday March 01, 2013 @07:31AM
|British researchers "gamify" cancer cure search
|Sunday February 10, 2013 @09:42AM
|Rapiscan's Backscatter Machines May End Up In US Federal Buildings
|Saturday February 09, 2013 @12:24PM
|Rapiscan's "backscatter" nude-o-scopes coming to federal buildings
|Thursday February 07, 2013 @09:36AM
|Startup Uses Radiation Fear To Map Cellphone Coverage
|Saturday December 22, 2012 @11:53PM
|Drugs Aim to Make Several Types of Cancer Self-Destruct
|Wednesday December 19, 2012 @03:39AM
|TSA (Finally) Studying Health Effects of Body Scanners
|Monday December 10, 2012 @09:26PM
|Four Cups of Coffee A Day Cuts Risk of Oral Cancer
|Sunday November 25, 2012 @09:00PM
|Finding an Open Source Cure for Brain Cancer
|Sunday November 18, 2012 @04:58PM
|Cancer can teach us about our own evolution
|Sunday October 21, 2012 @01:31AM
|Italian Supreme Court Accepts Mobile Phone-Tumor Link
|Friday October 19, 2012 @06:18PM
|TSA Moving X-ray Body Scanners To Smaller Airports
|Tuesday October 16, 2012 @08:40AM
|Cancer-Detecting Bra Could One Day Surpass Mammograms In Accuracy
|Friday October 05, 2012 @10:46AM
|Boston Airport Replacing X-ray Body Scanners
|Sunday September 30, 2012 @08:55AM
|Woman Successfully Grows Ear From Arm
|Tuesday September 04, 2012 @11:26PM
|Approval for Drug to Treat Type of Leukemia
|Thursday August 23, 2012 @08:25AM
|Cats Not Linked To Brain Cancer After All
|Tuesday August 07, 2012 @01:39AM
|Chemotherapy Can Make Cancer Growth Worse
|Sunday August 05, 2012 @05:18AM
|Non-Disease Virus Kills Breast Cancer Cells In Lab
|Friday August 03, 2012 @01:55AM
|Evidence Shows Cancer Regrowth Is Driven By Cancer Stem Cells
|Wednesday July 25, 2012 @04:03PM
|Wireless Car Charger Test Starts In London
|Tuesday July 24, 2012 @08:55AM
|Sally Ride Takes Her Final Flight
|Monday July 09, 2012 @07:53AM
|UCLA develops world's fastest camera to hunt down cancer in real time
|Monday July 02, 2012 @06:15PM
|Caffeine Linked To Lower Skin Cancer Risk
|Monday July 02, 2012 @11:32AM
|Caffeine Linked to Lower Skin Cancer Risk
|Sunday July 01, 2012 @11:51AM
|Micro-machines To Start Making Medicine Inside Our Bodies
|Tuesday June 26, 2012 @10:35AM
|Transplant Surgeon Called Dibs On Steve Jobs' Home
|Wednesday June 20, 2012 @02:18PM
|Patch Makes Certain Skin Cancers Disappear
|Tuesday June 12, 2012 @08:09AM
|DNA Modifications Change As We Age
|Thursday May 17, 2012 @05:46PM
|Researchers Hack Google's Search Algorithms to Fight Cancer
|Thursday May 10, 2012 @08:35AM
|Jars of Irradiated Russian Animals Find a New Purpose
|Monday May 07, 2012 @09:18PM
|Low Oxygen Cellular Protein Synthesis Mechanism Discovered
|Monday May 07, 2012 @09:09PM
|Low Oxygen Cellular Protein Synthesis Mechanism Discovered
|Monday April 16, 2012 @03:22AM
|Nanoparticles paint a precise picture of brain tumors before and during surgery
|Tuesday April 10, 2012 @12:29PM
|Dental X-Rays Linked To Common Brain Tumor
|Sunday April 08, 2012 @10:48PM
|Harvard Scientists Develop Nanorobots to Kill Cancer Cells
|Sunday April 08, 2012 @10:44PM
|Photoacoustic Imaging Uses Sight, Sound For Cancer Detection
|Friday April 06, 2012 @12:11PM
|Using Nanoparticles To Improve Chemotherapy
|Friday April 06, 2012 @09:09AM
|Majority of Landmark Cancer Studies Cannot Be Replicated
|Thursday April 05, 2012 @01:51PM
|Majority of landmark cancer studies cannot be replicated
|Monday March 26, 2012 @11:46PM
|Single antibody shrinks variety of human tumors transplanted into mice
|Monday March 26, 2012 @10:55PM
|Drug Turns Immune System Against All Tumor Types
|Friday March 23, 2012 @07:37AM
|Aspirin Helps Prevent Cancer, New Studies Show
|Thursday March 22, 2012 @11:49AM
|Groundbreaking Study Shows Aspirin Prevents Cancer
|Monday March 12, 2012 @02:51PM
|Algorithm Brings Speedier, Safer CT Scans
|Monday March 12, 2012 @10:15AM
|MIT Fiber Points To Woven Glasses-Free 3D Displays
|Friday March 09, 2012 @01:05PM
|BBC News - Coke and Pepsi alter recipe to avoid cancer warning
|Wednesday March 07, 2012 @06:09PM
|Training an Immune System To Kill Cancer: a Universal Strategy
|Tuesday March 06, 2012 @10:55PM
|Training an Immune System to kill Cancer: A Universal Strategy
|Tuesday March 06, 2012 @09:35AM
|After Legal Fight, NCI Researchers Publish Study Linking Diesel Exhaust, Cancer
|Thursday February 02, 2012 @10:45AM
|In Small WV Town, Monsanto Faces Class-Action Suit Over Agent Orange Chemical
|Thursday February 02, 2012 @09:24AM
|Crab Robot Helps Remove Stomach Cancer
|Monday January 30, 2012 @11:19AM
|Maine Senator Wants Independent Study of TSA's Body Scanners
|Wednesday January 25, 2012 @12:46PM
|2012 Japan Prize Honors Magnet Creator and Cancer Researchers
|Monday January 23, 2012 @11:56AM
|Nano-Scale Terahertz Antenna May Make Tricorders Real
|Sunday January 15, 2012 @11:44AM
|DHS' X-ray Car Scanners Now At Border Crossings
|Friday December 16, 2011 @04:09PM
|Could This Be The End Of Cancer?
|Monday December 05, 2011 @04:43AM
|Toxic Montana Lake's Extremophiles Might Be a Medical Treasure Trove
|Thursday December 01, 2011 @09:25AM
|'Alternative Medicine' Clinic Attempts To Silence Critics
|Friday November 18, 2011 @02:21PM
|Naked Mole Rats from Outer Space
|Thursday November 10, 2011 @09:29AM
|Computer more accurate than human doctor at breast
|Sunday October 30, 2011 @02:41PM
|Cancer Screening Considered Harmful
|Wednesday October 26, 2011 @11:04PM
|New Non-Invasive Technique Using Light Finds Pre-C
|Wednesday October 26, 2011 @03:28AM
|HPV Vaccine Recommended For Boys
|Tuesday September 13, 2011 @06:17PM
|An Immune System Trained to Kill Cancer
|Thursday September 01, 2011 @07:32PM
|EPIC Uncovers: Mobile Scanners Not 'Certified People Scanners'
|Wednesday August 24, 2011 @12:47AM
|Redesigning ecstasy as potent cancer treatment
|Friday August 19, 2011 @04:47AM
|Study shows dogs can sniff out lung cancer
|Thursday August 11, 2011 @01:29PM
|Cancer Cured By HIV
|Wednesday August 10, 2011 @04:48PM
|New Treatment for Leukamia exceeds expectations
|Wednesday August 03, 2011 @09:59PM
|Building Material Absorbs and Releases Heat
|Thursday July 28, 2011 @02:38PM
|Another Cell Phone-Cancer Study Emerges
|Thursday July 28, 2011 @11:09AM
|Study:There Is No Relation B/W Cellphones & Ca
|Thursday July 21, 2011 @03:19AM
|TSA Body Scanners To Show Less Revealing Images
|Monday June 27, 2011 @01:58PM
|Cancer cluster possibly found among TSA workers
|Friday June 03, 2011 @08:40PM
|Brain Cancer Worries? Look Up Your Phone's SAR
|Thursday June 02, 2011 @02:30PM
|Senior Citizens Lining Up to Tackle Fukushima
|Wednesday June 01, 2011 @05:05PM
|Cell phone link to brain cancer overhyped?
|Tuesday May 31, 2011 @01:44PM
|WHO: Cell Phones May Cause Cancer
|Wednesday May 18, 2011 @09:33AM
|Coffee Wards Off Cancer
|Wednesday May 18, 2011 @08:18AM
|Coffee wards off cancer
|Sunday April 17, 2011 @10:04AM
|Portable brain tumor treatment system kills cancer
|Thursday March 10, 2011 @03:39PM
|Smartphone Device that Detects Cancer in an Hour
|Friday March 04, 2011 @02:48PM
|LED Technology Reduces Chemotherapy's Side Effects
|Thursday March 03, 2011 @07:05PM
|DHS Eyes Covert Body Scans
|Thursday February 17, 2011 @05:37PM
|Steve Jobs Health Worries Escalate
|Monday November 08, 2010 @10:42PM
|BackScatter machines really safe?
|Sunday October 31, 2010 @12:46PM
|TSA To Make Pat-Downs More Embarrassing To Encourage Scanner Use
|Tuesday October 26, 2010 @07:57AM
|Inside a Full-Body-Scanning X-Ray Van
|Monday October 25, 2010 @01:38PM
|Inside a Full-Body Scanning X-Ray Van
|Tuesday October 19, 2010 @03:44PM
|Ontario School Bans Wi-Fi
|Sunday October 03, 2010 @07:17PM
|Neurosurgeons Use MRI-Guided Lasers To Destroy Tumors
|Tuesday September 14, 2010 @02:48PM
|Fujitsu Eyes Wireless Gadget Charging For 2012
|Saturday August 14, 2010 @05:23PM
|Preserving Memories of a Loved One?
|Friday August 06, 2010 @10:38AM
|Regenerate muscle cells with newt-inspired tech.
|Monday July 19, 2010 @06:49AM
|Genetically Engineered Immune Cells Kill Cancer
|Sunday July 18, 2010 @01:00AM
|US Deploys 'Heat-Ray' In Afghanistan
|Thursday July 15, 2010 @03:45AM
|Wireless PCIe To Enable Remote Graphics Cards
|Wednesday July 07, 2010 @03:05PM
|Doctor Invents "Zero Gravity" Radiation Suit
|Wednesday June 30, 2010 @02:10PM
|Cancer Cells Detected Using $400 Digital Camera
|Monday June 28, 2010 @11:42AM
|New drug protects from radiation
|Monday May 17, 2010 @01:18PM
|10-Year Cell Phone / Cancer Study Is Inconclusive
|Sunday May 16, 2010 @02:52PM
|Cell phones & cancer: definitely maybe
|Friday May 14, 2010 @12:33AM
|Cheap Cancer Drug Finally Tested In Humans
|Thursday April 29, 2010 @10:07PM
|FDA Approves Vaccine For Prostate Cancer
|Friday April 23, 2010 @03:24PM
|Biggest Study On Cellphone Health Effects Launched in Europe
|Tuesday April 20, 2010 @05:29PM
|Anti-Cancer Agent Stops Metastasis In Its Tracks
|Thursday April 15, 2010 @01:34PM
|DNA Cancer Codes Cracked By International Effort
|Wednesday April 14, 2010 @01:35PM
|DNA cancer codes cracked by international effort
|Tuesday March 30, 2010 @09:18PM
|Gonorrhea As the Next Superbug
|Tuesday March 30, 2010 @05:50PM
|US District Judge Rules Gene Patents Invalid
|Tuesday March 30, 2010 @05:06PM
|Gonorrhea: The Next "Superbug"?
|Monday March 15, 2010 @09:06PM
|Golden Nanocages To Put the Heat On Cancer Cells
|Tuesday March 09, 2010 @05:03PM
|Doctors Skirt FDA To Heal Patients With Stem Cells
|Monday March 08, 2010 @05:06AM
|Lessons of a $618,616 Death
|Saturday March 06, 2010 @11:06PM
|Lessons of a $618,616 Death
|Thursday March 04, 2010 @06:57AM
|Common Herbicide Causes a Sex Change In Frogs
|Sunday February 07, 2010 @02:52AM
|Studies Find Harm From Cellular and Wi-Fi Signals
|Wednesday February 03, 2010 @03:35AM
|Spray-On Liquid Glass
|Sunday January 10, 2010 @04:26AM
|Wireless Power Group Sees Standard Within 6 Months
|Thursday January 07, 2010 @10:51PM
|Cellphone Radiation May Protect Brain From Alzheimers
|Wednesday December 16, 2009 @05:18PM
|Scientists crack 'entire genetic code' of cancer
|Friday December 11, 2009 @01:43PM
|Method To Repair Damaged Adult Nerves Discovered
|Friday December 04, 2009 @12:25PM
|Cell Phones Don't Increase Chances of Brain Cancer
|Friday November 27, 2009 @04:13PM
|Cancer Vaccine That Mimics Lymph Node
|Friday November 27, 2009 @12:16PM
|Cancer Vaccine That Mimics Lymph Node
|Saturday October 31, 2009 @02:59AM
|How Terahertz Waves Tear Apart DNA
|Wednesday October 28, 2009 @02:00PM
|The Best Medications For Your Genes
|Tuesday October 27, 2009 @04:51PM
|Discovery of "Cancer-Proof" Rodent Cells
|Tuesday October 27, 2009 @12:16PM
|Discovery of 'cancer-proof' rodent cells
|Thursday October 15, 2009 @01:44PM
|Electro-Scalpel "Sniffs Out" Tumors
|Wednesday October 14, 2009 @04:41PM
|Surgical Electro-Scalpel 'Sniffs Out' Tumors
|Saturday October 03, 2009 @08:58AM
|Sony Prototype Sends Electricity Through the Air
|Friday October 02, 2009 @09:46AM
|Common Diabetic Drug Fights Cancer Stem Cells
|Tuesday September 15, 2009 @03:57PM
|Stem Cell Transplant Cures HIV Infection
|Wednesday September 09, 2009 @07:04PM
|US Nuclear Power Industry Poised For a Comeback
|Tuesday September 01, 2009 @04:09PM
|Japan Plans $21B Space Power Plant
|Monday August 17, 2009 @09:24PM
|Wireless Power Consortium Pushes for "Qi" Standard
|Wednesday August 05, 2009 @05:52PM
|Sticky Tape Found To Emit Terahertz Radiation
|Tuesday July 28, 2009 @05:43AM
|New Treatment Trains Immune System To Kill Cancer
|Monday June 22, 2009 @03:55PM
|Intel Demos Wireless "Resonant" Recharging
|Friday May 08, 2009 @08:56PM
|60GHz Uber-WiFi Proposed By New WiGig Group
|Saturday May 02, 2009 @01:27PM
|Time To Cut the Ethernet Cable?
|Sunday April 19, 2009 @04:32PM
|Stem Cell Treatment To Cure the Most Common Cause of Blindness
|Monday March 16, 2009 @04:25PM
|Europe Is Testing 12.5 Gbps Wireless
|Friday January 23, 2009 @08:59PM
|First Human Embryonic Stem Cell Study Approved
|Thursday January 15, 2009 @12:33PM
|Steve Jobs Takes Leave of Absence From Apple
|Saturday January 10, 2009 @03:18PM
|Increasing Stem Cell Production For Faster Healing
|Tuesday January 06, 2009 @02:57AM
|Steve Jobs Issues Update On His Health
|Tuesday January 06, 2009 @02:16AM
|Tooth Regeneration Coming Soon
|Friday December 19, 2008 @10:55AM
|Wireless Power Consortium Pushes For Standard
|Thursday December 11, 2008 @10:26PM
|Pushing 800W of Wireless Power at 5 Meters
|Friday December 05, 2008 @04:48AM
|Prototype Scanner Detects Cancer In Under 1 Hour
|Tuesday November 25, 2008 @11:47PM
|Indonesians Want To Microchip AIDS Patients
|Thursday November 06, 2008 @12:19PM
|First Whole Cancer Genome Sequenced
|Tuesday October 28, 2008 @09:37AM
|Why Your Clock Radio Is All Abuzz About iPhones
|Thursday October 23, 2008 @07:35PM
|Researchers Developing Cancer-Fighting Beer
|Sunday October 05, 2008 @11:08AM
|Computer Detection Effective In Spotting Cancer
|Saturday October 04, 2008 @04:04AM
|Replacing Fiber With 10 Gigabit/Second Wireless
|Monday August 25, 2008 @10:59AM
|California Classes LED Component Gallium Arsenide a Carcinogen
|Monday July 28, 2008 @07:50PM
|$1,000 Spray Makes Gadgets Waterproof
|Monday June 30, 2008 @03:07AM
|Cancer Resistance Technique Moves To Human Trials
|Friday April 25, 2008 @11:02PM
|Focused Microwaves Could Enable Wireless Power Transfer
|Monday March 17, 2008 @06:43AM
|Harvard Scientists Aim To Stop Cancer In Its Tracks
|Tuesday March 04, 2008 @06:05AM
|Key Step In Programmed Cell Death Discovered
|Sunday January 13, 2008 @04:08PM
|Proposal for UK Prisoners to be Given RFID Implants
|Friday December 21, 2007 @08:47AM
|Stem Cell Lines Derived to Avoid Immune Rejection
|Tuesday November 20, 2007 @03:05PM
|Cannabis Compound Said To "Halt Cancer"
|Thursday November 15, 2007 @12:38AM
|The Nuclear Power Renaissance
|Sunday September 09, 2007 @05:50AM
|Implanted RFID Chips Linked To Cancer
|Thursday September 06, 2007 @03:51PM
|Detecting Cancer Without Drawing Blood
Beware of Programmers who carry screwdrivers. -- Leonard Brandwein


text:
iHerb Customer Reviews
Verified Purchase
雖然我沒有特別愛這一款,但一個禮拜還是泡上一回,換個口味!!! 但我朋友好愛這個口味~
Was this review helpful to you?
Great coffee alternative
Posted by iHerb Customer on Apr 26, 2013 | Verified Purchase
I have been drinking this instead of coffee in the mornings for years now and love that I can have a few cups and never get jittery or crash later in the day. I personally prepare it in my drip coffee and mix in a litte Teeccino (which you can also find here on iHerb) which balances out the taste and gives it even more body - it's an awesome combination!
Posted by iHerb Customer on Jun 02, 2015 | Verified Purchase
雖然我沒有特別愛這一款,但一個禮拜還是泡上一回,換個口味!!! 但我朋友好愛這個口味~
Posted by MikeMember on Oct 08, 2012 | Verified Purchase
I looks like coffee, but it doesn't taste like coffee. It's a delicious break from coffee and unwanted caffeine.
Best Coffee Alternative Ever!!
Posted by iHerb Customer on Feb 24, 2017 | Verified Purchase
iHerb sent this product quickly & at a good price. I'm super happy about it. What a great find! Ann Aiken
Excellent product
Posted by iHerb Customer on Dec 30, 2016 | Verified Purchase
My favorite tea product and very happy that you have it.
Posted by 53980jj on Jun 17, 2016 | Verified Purchase
和咖啡紅茶的提神振奮感不同,mate喝了神清氣爽,心情很放鬆卻又很有活力, 讓人ㄧ整天的好心情. 建議用2或3茶匙泡ㄧ杯,回沖第2,3次時可以用熱一點的水泡個10分鐘,會幾乎和剛泡第一杯時一樣濃.
Posted by iHerb Customer on Jun 01, 2016 | Verified Purchase
really it is good to me!! i will buy again
Good Coffee Replacement
Posted by iHerb Customer on Jan 29, 2012 | Verified Purchase
I've used this Yerba Mate to get myself down to one cup of coffee in the morning. It gives me energy without making me jittery. It doesn't taste like coffee, but has the same richness. I add a packet of Stevia and enjoy the taste.
Yerba Mate
Posted by iHerb Customer on Jan 09, 2013 | Verified Purchase
Need to add more chicory to the blend. That'll be nicer.
1-9 of 9 total


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The first video of DayZ Standalone has been released this week! It's nearly 15 minutes long and features the game's creator, Dean "Rocket" Hall, explaining what you're seeing. A good deal of the video deals with clothing, but the real good stuff comes at the tail-end where the the Dean Hall and production assistant Matt Lightfoot go into how loot spawning has changed! No word on when the standalone version of DayZ will be released, but they did say that the team at Bohemia Interactive is hard at work!
Rocket and Matt provide a quick overview of some new elements of the DayZ Standalone project. Includes the new engine support for clothing, the revised loot spawning mechanics, and some new areas on the map.
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Process Automation Systems: How Secure Is Secure Enough?
Where Do you Draw the Line in Applying Security to Your Systems?
Industrial control systems are the heart of manufacturing worldwide. Every sort of manufacturing process from semiconductors to oil and gas and in between uses an industrial control system. Some are relatively simple, such as a PLC controlling a work cell on a factory floor. Some are more complex, such as a DCS in a refinery. Others are extremely complex, such as a SCADA system at a mine with more than 100,000 I/O points.
Like enterprise computing, industrial control systems have traveled a path from standalone systems to the modern, highly interconnected world of Ethernet, the Internet and cloud-based computing.
But while enterprise computing and even home computing started confronting cyber attacks a decade ago, the industrial control systems lagged far behind. One of the main reasons is that there is a significant difference between the asset lifecycles in the enterprise computing and the industrial control system spaces. Enterprises see nothing unusual about replacing all their systems every two to three years, but industrial control systems are designed and operated to be replaced every 20 to 30 years, and some are kept going to the end of the useful life of the plant itself.
So, while enterprise IT has managed to keep up with cybersecurity, anti-virus and network defense by continually upgrading its systems, most industrial control systems have relied on what has been called by many cybersecurity researchers, "security by obscurity."
All of these industrial control systems share a common flaw. "They are all highly reliable, purpose-built and very efficient," says Patrick Miller, president and CEO of EnergySec in Portland, Ore., a not-for-profit educational institution devoted to improving security in the energy sector. "However, most platforms are not secure. They were never designed with security in mind."
Beginning in the early 1990s, enterprise computing systems and networks were quickly connected to other networks and the Internet. Industrial control systems didn't begin to be connected to even their own enterprise networks until a decade later, and in many cases, the connections were done inadvertently.
The media, both popular and technical, have been discussing severe vulnerabilities like the Stuxnet virus, supposedly built as a cyberweapon by the United States and Israel to attack process plants in Iran. Another severely problematic vulnerability is Aurora, which destroyed a piece of electric grid infrastructure.
Marco Ivaldi, senior security advisor from @mediaservice.net, an Italian security researcher and "hacker," says, "I think there is still a long way to go to reach a proper level of security in either the process industries or the electric utility space." Ivaldi went on to discuss several extremely dangerous vulnerabilities in commonly used industrial control system components from a variety of vendors.
In addition, in July, Siemens self-reported three vulnerabilities in WinCC and Simatic Step 7.
And so it continues.
Almost every government has taken steps to try to do something, anything, to improve the security posture of industrial control systems because they are part of the critical infrastructure of a modern economy. It remains to be seen if any of those steps have actually done so.
Are We Any More Secure This Year Than Last?
"This," says Eric Byres, CTO of the Tofino Security division of Belden Inc., "is a tough question, because what we have happening is an arms race between the good guys and the bad guys. Both the vendors and the end users are slowly becoming security aware and are starting to provide and deploy good security technologies and practices. Unfortunately, the bad guys are also becoming more aware of the opportunities to attack industrial systems—we can thank Stuxnet for that—and at the same time, the tools available for security attacks on ICS and SCADA systems are rapidly improving."
After interviewing more than a dozen industrial control system security professionals, including end users, security researchers, suppliers and experts in just about every industrial vertical, it is clear that the very best answer to the are-we-more-secure question is a resounding, "maybe, maybe not."
"So the answer to the question," Byres says, "is that many ICS and SCADA systems are more secure than they were last year, but the bad guys are better equipped."
John Cusimano, director of security solutions for exida and director of the Repository of Industrial Security Incidents (RISI), says, "Overall the security posture of most control systems is still fairly weak. It varies significantly by industry, though. Major oil and gas and chemical companies are actually doing fairly well."
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<p>As a retired entrerprise IT pro I liked this article very much. It shows security thinking 'the other way round', which is an enrichment even for persons not involved with ICT. </p>
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text:
Sore triceps nixes Lewis' bullpen session
Texas righty not concerned, but scheduled rehab start likely to be delayed
HOUSTON -- The Rangers are hoping pitcher Colby Lewis is experiencing just a minor setback in his recovery from flexor tendon surgery. Lewis pitched two innings in his first start on medical rehabilitation assignment Thursday night for Triple-A Round Rock and has developed some soreness in his right triceps muscle.
Lewis did not throw a scheduled bullpen session on Saturday, although he did play catch. He was supposed to make his second start on Tuesday against Tucson, but that is likely to get pushed back.
"It's not too dissimilar from what we see with a lot of guys in Spring Training," general manager Jon Daniels said. "My hope is that's all this is. We'll see."
Lewis, who underwent flexor tendon surgery on July 27, made two starts in extended spring training before beginning his 30-day medical rehabilitation assignment on Thursday against Las Vegas. He threw 41 pitches over two innings in the game, and another 12 in the bullpen afterward.
He is supposed to throw 60-65 pitches in his next start, although the Rangers don't know when that will be. Lewis doesn't expect to wait long.
"Not concerned, just arm getting back into throwing shape," Lewis told reporters by text message.
T.R. Sullivan is a reporter for MLB.com. Read his blog, Postcards from Elysian Fields, and follow him on Twitter @Sullivan_Ranger. This story was not subject to the approval of Major League Baseball or its clubs.


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Industrial Services Business ListingsIndustrial Supplies and Services for professionals including information about chemicals, amusement devices, commercial cleaning services, machines and machinery and many more.
An industry is the manufacturing of a good or service within a category. Although industry is a broad term for any kind of economic production, in economics and urban planning industry is a synonym for the secondary sector, which is a type of economic activity, involved in the manufacturing of raw materials into goods and products.
There are several branches of technology and engineering specialised for industrial application. This includes mathematical models, patented inventions and craft skills.


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A CARER who helped identify a gang of fraudsters has been given an award.
Wendy Sonley cares for an elderly Parkinson's sufferer in the Malton area, and in October 2012 discovered he had repeatedly made payments totalling £250,000 in eight years to an organised crime group posing as property repair tradesmen.
She alerted North Yorkshire Police, and a Trading Standards investigation - Operation Opal - subsequently found similar victims in York, Harrogate and Bridlington had been defrauded out of tens of thousands of pounds by the gang.
Mrs Sonley received a Hero Award at the Trading Standards Institute's (TSI) Conference in Harrogate this week, and won praise from County Councillor Chris Metcalfe, executive member for Trading Standards.
Coun Metcalfe said: "We are deeply grateful to Wendy for her vigilance and her courage in alerting officers to this terrible crime against a vulnerable and elderly member of our community.
"She is an example to all of us of the role we can play in the fight against doorstep crime. Members of the public must not under-estimate the vital role they can play in reporting such offending and doorstep callers to us immediately. Offenders need to be aware that we are utterly committed to bringing them to justice and using all available tools to target their behaviour."
North Yorkshire County Council Trading Standards said the fraud - which saw over-priced, shoddy and unnecessary property repairs carried out - was the worst example of repeat victimisation it had ever encountered.
The men, Monty David Croke, 46, of Field Drive, Pickering; his two sons, Monty Croke Jr, 26, and Billy Croke, 23, both of Thistle Hill Travellers Site, Knareborough; and James Paul Coverdale, 35, of Ings Garth, Pickering; pleaded guilty to conspiring to defraud householders in relation to shoddy, over-priced and unnecessary property repairs.
In February 2014, Monty David Croke was jailed for five years; Monty Croke Jnr for two and a half years, Billy Croke for 12 months and James Paul Coverdale for 15 months, suspended for two years. In May, the Court of Appeal increased the sentences for the two main offenders to seven and a half years and four years.


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HOLLYWOOD actor Mark Beltzman, who has appeared in Seinfeld and Curb Your Enthusiasm, held workshops with budding Trowbridge actors last week as part of a new arts project.
Mr Beltzman, 52, held classes in 'improv' at Trowbridge Town Hall and at The Arc Theatre.
Improv is a form of unscripted performance, which involves the skills of listening and co-operation; Mr Beltzman was a founding member of Improv Olympic, in Chicago, during the 1980s.
He said: "I had a lovely time and the town hall was a great teaching space. There was a really good standard at the workshops."
Mr Beltzman has now returned to London and will be giving more classes before returning to America on February 25 in time to take part in the New York Improv Festival in March.
He said: "It was a pleasure to work with the kids over here and I would love to come back to the UK in the future.
"I teach, I act in movies and I'm also a comedian and musician so I really enjoy having variety in my life."
The workshops kick-started a new project between Trowbridge Arts and BA14 Culture. The latter has received around £120,000 in funding from bodies including Arts Council England, Wiltshire Council and Trowbridge Town Council.
Tracy Sullivan, director of Trowbridge Arts, said: "We are over the moon that Trowbridge has been successful in a bid made to the arts council to support the delivery of professional performance, workshops and visual arts, and we're thrilled to welcome Mark to inspire people of all ages and abilities at the very beginning of this two year project."
As part of their plans, the groups want to introduce a new audience to arts in the town and offer more to the one that already exists.
To celebrate the start of the project, Trowbridge Arts is planning to hold a launch event.
Anyone who would like to host workshops, performances and exhibitions is welcome to get in touch with the organisation.
For more information about the project, email firstname.lastname@example.com or call Tracy on 07540 938936.


text:
Nine Stars Sensor Recycle Unit - Stainless Steel - 18.5 Gallons
by Nine Stars | Item #: 9555 | Model #: DZT-70-11R |
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About this item$9 standard shipping
The future is now with Nine Stars auto opening recycle unit.
Nine Stars sensor trashcans automatically open when in range and automatically close for you when out of range. Included is a ring liner which holds the trash bag up and conceals the trash bag while inside the trash can. With the divided base this can offers one side for recyclables and one side for trash. It performs 10,000 opening and closings of the lid before needing to change the batteries, and has a 1 year limited manufacturer's warranty on the mechanism of the lid only. Operates with hands free / foot free operation to help reduce cross contamination.
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- 18.5 gallon / 70 liter stainless steel sensor recycle unit
- Hands free operation
- Lid automatically opens and closes for you when in range
- Ring liner holds trash bag up and conceals trash bag inside trash can
- 10,000 openings and closings before changing batteries
- Finger print resistant stainless steel
- Operates on 4 "D" batteries (not included)
- Non skid base
- Half moon design
- Divided base one side for trash one side for recyclables
Assembled Country
Assembled Size
21.3" x 13.0" x 26.2"
Component Country


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