text:
Trail, B.C. – TELUS will invest $700,000 in Trail in 2012 to further expand and enhance its wireless and wireline networks.
"TELUS' $700,000 investment will enhance our world-class wireless network and improve Internet speeds for businesses and households right here in Trail," said Steve Jenkins, TELUS general manager of Customer Solutions Delivery for the community. "TELUS is committed to making investments in infrastructure and technology to better serve our customers and communities. We are deeply grateful for the hard work and outstanding commitment of our nearly 20 local team members and retirees and for the support of our customers."
This significant investment is part of $3 billion in infrastructure upgrades being made across British Columbia through 2014 and builds upon the $26 billion TELUS has already invested in operations and technology throughout the province over the last 10 years.
TELUS' commitment also extends to supporting local charities and community organisations.
"As important as our infrastructure investments are to our success, our commitment to local community organisations is near and dear to our hearts. TELUS believes deeply in the symbiotic relationship between the success of business and the welfare of our communities," continued Jenkins. "We embrace a simple philosophy – we give where we live – and we take great pride in the social outcomes we are helping to realize. Since 2000, our TELUS family of 25,000 employees and retirees in B.C. has donated over $100 million dollars and, more importantly, volunteered 2.4 million hours, with our hearts and our hands, to community and charitable organisations. Additionally, the TELUS team will contribute a further $10 million dollars to local, grassroots community projects in 2012."
TELUS' $700,000 investment in 2012 will:
• Further expand and enhance its wireless and wireline networks in Trail.
• Bring advanced wireless and wireline broadband to nearby rural communities. TELUS has already started this work in the Southern Interior – where the company is investing an average of $650,000 per community to bring broadband service to local residents in Boswell, Appledale, Elko, Blackpool, Jaffray, Christina Lake, Lilttle Shuswap Lake, Upper Nicola, Thrums, Trout Lake, Neskonlith and Siska this year.
The capital investment disclosed in this release is consistent with TELUS' overall capital expenditure guidance for 2012.
About TELUS
TELUS (TSX: T, T.A; NYSE: TU) is a leading national telecommunications company in Canada, with $10.4 billion of annual revenue and 12.7 million customer connections including 7.3 million wireless subscribers, 3.6 million wireline network access lines and 1.3 million Internet subscribers and more than 500,000 TELUS TV customers. Led since 2000 by President and CEO, Darren Entwistle, TELUS provides a wide range of communications products and services including wireless, data, Internet protocol (IP), voice, television, entertainment and video.
In support of our philosophy to give where we live, TELUS, our team members and retirees have contributed more than $260 million to charitable and not-for-profit organisations and volunteered 4.2 million hours of service to local communities since 2000. Eleven TELUS Community Boards across Canada lead TELUS' local philanthropic initiatives. TELUS was honoured to be named the most outstanding philanthropic corporation globally for 2010 by the Association of Fundraising Professionals, becoming the first Canadian company to receive this prestigious international recognition.
For more information about TELUS, please visit telus.com.
Forward looking statement:
This news release contains statements about expected future events of TELUS that are forward-looking. By their nature, forward-looking statements require the Company to make assumptions and predictions and are subject to inherent risks and uncertainties. There is significant risk that the forward-looking statements will not prove to be accurate. Readers are cautioned not to place undue reliance on forward-looking statements as a number of factors could cause actual future events to differ materially from that expressed in the forward-looking statements. Except as required by law, TELUS disclaims any intention or obligation to update or revise forward-looking statements.
For more information, please contact:
Shawn Hall
TELUS Media Relations
(604) 619-7913
B-roll of TELUS infrastructure projects in B.C. can be downloaded from the following FTP site:
Username: 12-079
Password: t3lu5


text:
If you are a Microsoft® Outlook® user, you probably have it open all the time.
Now you can have a fully-featured, powerful Twitter client at your fingertips without having to open any other applications. TwInbox seamlessly integrates Twitter into Outlook.
It is a perfect Twitter client for any Outlook user, from a Twitter newbie to a business professional.
Follow @TechHit on Twitter to receive update notifications.
Why did we build TwInbox? Because Twitter is fun and we build Outlook products for a living. So we thought why not throw them together and see what happens. What do you think? TwInbox is still a very young product. We would love to hear your questions, comments, suggestions, praises, rants... We'd like to hear from you!
Microsoft, Outlook and the Office logo are trademarks or registered trademarks of Microsoft Corporation in the United States and/or other countries.
Questions? Call us
1 415-354-9711

subset: commoncrawl


text:
Welcome to the Brady's Michigan Sharpshooters Homepage!
Brady's Michigan Sharpshooters, based in Northern Virginia and Maryland is a unit of Civil War reenactors dedicated to introducing people to the fun and history of Civil War reenacting. We have some additional uniforms and equipment for use to anyone interested in taking the field and discovering the taste of battle. After your first battle we do encourage you to begin to purchase your own uniform if you are interested in continuing. See our Company Quartermaster page for more information about unit uniform requirements. If you would like to enlist or would just like more information about our unit and this exciting hobby, please visit our Frequently Asked Questions page or e-mail our Recruiting Staff.
Brady's History
Brady's Sharpshooters (officially Michigan's First Company of Sharpshooters), was directly authorized by the War Department in late summer 1861, and saw action right through to the end of the war, from Yorktown, through Chancellorsville, Gettysburg (where the men fought as skirmishers in defense of Little Round Top), Grant's drive on Richmond, to the surrender at Appomattox. In fact, with the exception of First Bull Run, the men of Brady's Sharpshooters were present for virtually every significant engagement of the Army of the Potomac, in addition to reinforcing General John Pope's Army of Virginia for the Second Battle of Bull Run.
The company was named in honor of frontier army general, Hugh Brady, whose Brady Guards militia included in the 1840s one Kiniston S. Dygert. In 1861, Captain Dygert, considered one of the best marksmen in the state, was given the commission to organize an independent company of sharpshooters. Dygert's recruitment poster outlined the strict qualifications for members of the company: " No man will be accepted or mustered into service who cannot, when firing at rest at a distance of 40 rods (220 yards), put ten consecutive shots in a target of an average space not to exceed five inches from the center of the bull's eye to the center of the ball."
Although issued standard military rifles, many of the volunteers brought with them their personal customized target rifles, often equipped with telescopic sights, which were used in local shooting competitions. The special mission and origin of these sharpshooters helps to explain the strong esprit de corps of the unit, and why, throughout its service, no draftees were ever included; all of the Brady's Sharpshooters were volunteers, and though casualty rates were high, there was only one desertion in the field.
Historical Information
Brady's Historical Company Roster by Wayne Abernathy
Period Photos of Original Members of Brady's Sharpshooters
Brady's Original Recruiting Poster
A Guide to the Arms of Brady's Sharpshooters by Wayne Abernathy
Excerpts from the Official Records of the Civil War and Dyer's Compendium regarding Brady's Sharpshooters
School of the Company by Josh Mordin
Table of Pay from the 1861 U.S. Army Regulations
|Reenacting Information
|Reenacting Resources
|Recruiting Frequently Asked Questions
|Civil War Links
|Safety and Authenticity
|Where to find scopes?
|Company Quartermaster
|Photo Gallery - Updated Oct 2009
Company Staff
|Mike Schaffner
Officer Commanding
Administrative Chairman
Brady's Sharpshooters at Gettysburg Remembrance Day Parade
Photograph by R.J. Szabo, November 2000
2014 Schedule of Events (Tentative)
|Unit POC
|February 8
|Company Administrative Meeting
Ft Teller, MD
|Pvts Andy and John


text:
The circadian rhythm explains why you feel creatively sharp in the morning, have trouble focusing in the late afternoon, and start yawning as the sun goes down. It's a built-in part of our bodies, although we all experience it at different times, and that's going to affect your family's game-playing routine.
Before grabbing the kids at 8:47 p.m. in hope of slipping in a quick round of the family's favorite strategy game, take a moment for a mood check.
Start with yourself. Are you ready to be patient and calm if one of the kids takes a long time to make a move in the game? Can you endure a run of bad luck without being snarky? Do you have enough energy to smile and keep the game moving forward?
What about your significant other, if he or she plans to be part of the game as well? What's the reading there?
Finally - and most importantly - check the kids. Your kids are, well, kids, so they're still learning how to deal with their unique rhythms.
As the adult, it's your responsibility to suck it up a little bit and make some magic happen for your kids, even if you don't feel 100 percent (or even 60-70 percent). That means you need to help them proactively by using your elite parenting skills.
Next, think about the time. Is it a school night or a weekend? Were the kids particularly active during the day or do they have energy left? Do they usually lose concentration after a particular hour?
When my kids were in their tweens and teens, we could play pretty much any kind of game if we started by 7 p.m. If we didn't get organized until 8 p.m., then we needed something with light strategy and fast play.
Of course, I didn't always remember my own guidelines, which led to some memorably bad evenings. We'd get 45 minutes into a game, but then the kids couldn't focus (or, worse, one could but the other couldn't) and I found myself dangerously short on patience. It was a bad combination all the way around.
If you see that happening to your family, just pause the game and come back to it the next day. You can say something like this: "I think we're too tired to make this fun right now, and I really want to have fun with you. How about pausing for now and picking it up again tomorrow evening?"
As a parent, your kids look to you for guidance and help. They know they're tired, but sometimes they don't want to give up. Giving them permission to feel what they feel instead of pressing on like a soldier slogging through the snow is important. You're giving them space to be themselves, and you're respecting them as people.
That may seem like a small thing right now, but it's bigger than you think. Really.


text:
Sign into our member site to view your information online.Forget your username or password? Not registered? Register here
fluocinolone (generic name)
It is used to treat skin problems of the scalp that may cause itching and swelling
(floo oh SIN oh lone)
Table of Contents
Top Learning Centers(Recursos en Español)
What is this medicine?FLUOCINOLONE (floo oh SIN oh lone) is a corticosteroid. It is used to treat skin problems of the scalp that may cause itching and swelling.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
How should I use this medicine?This medicine is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Shake well before using. Apply the shampoo to the scalp and work into a lather. Leave on the scalp for about 5 minutes unless your doctor or health care professional tells you differently. Then, rinse your hair and scalp thoroughly to remove the shampoo. Do not use your medicine more often than directed or for a longer period of time than ordered by your doctor or health care professional. To do so may increase the chance of absorption through the skin and the chance of side effects. Do not bandage or cover the treated scalp area unless directed to do so by your doctor or health care professional. Do not get the shampoo in your eyes. If you do, rinse it out with plenty of cool tap water.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What may interact with this medicine?Interactions are not expected. Do not use any other scalp products without telling your doctor or health care professional.
What should I watch for while using this medicine?Tell your doctor or health care professional if your symptoms do not get better within one week. Tell your doctor or health care professional if you are exposed to anyone with measles or chickenpox, or if you develop sores or blisters that do not heal properly.
What side effects may I notice from receiving this medicine?Side effects that you should report to your doctor or health care professional as soon as possible:
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Where should I keep my medicine?Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from heat and direct light. Do not freeze. Throw away any remaining shampoo after three months.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


text:
For the entire month of May 2010, Footnote is offering free and unfettered access to its Historic Newspapers collection!
Check out your ancestors in the archives of hundreds of newspapers and you'll find vital information about events such as weddings, funerals and more!
I enjoy using Footnote's interface which lets me "clip" just the article I need and save it as a jpg file.
Start Your Free Trial with Footnote.com
© 2010, copyright Thomas MacEntee


text:
We get an early look at the Rick Owens Spring/Summer 2010 sneaker line-up. The designer presents two high top sneakers, both coming in premium leathers with some nice details, that are overall very subtle and only pop up at a closer look. As usual the footwear has its gothic feel, just like we are used to see from Rick Owens. The sneakers will be released February 2010 at Oki-Ni.
More views of the Rick Owens Spring/Summer 2010 Sneakers follow after the jump.


text:
Athletes on the U.S fencing team are getting up at dawn for long days of practice and sightseeing.
BY: Marshal Davis
For the last three days, Team USA Fencing has been taking a 6:30 a.m. bus to train at the Wingate Institute, Israel's national sports complex in Netanya. As our athletes are still catching up from jet lag while running all over this beautiful country, waking up this early is grueling. However, the fencers are taking it in stride, for the most part. After all, our team has some of the top fencers in the nation, including two 2013 national champions, NCAA All Americans and fencers high on the National Points list.
Practice has been going well and the team has also had opportunities to gel during cultural tours and dinners. The athletes are forming bonds and friendships that will last a lifetime. It's fantastic to witness older, more experienced fencers taking the younger athletes under their wings and serving as quality role models.
Since arriving in Israel, we've been fortunate to visit Jaffa, Tel Aviv, Bell Beach in Herzliya, the Yad La-Shiryon memorial, archaeological sites at Bet Guvrin-Maresha National Park, Jerusalem's Old City and Western Wall, the City of David and the Temple Mount. The USA delegations also gathered for a huge barbecue at Kfar Maccabiah.
We're currently on a bus from Kibbutz Shefayim, where we are staying, to the Dead Sea. From there, our group will head to Masada and end the day with dinner in a Bedouin tent.
Signing off from the road to the Dead Sea,
Marshal Davis
Outside of coaching the U.S. Fencing team at Maccabiah, Marshal Davis works as an attorney at Davis Law and coaches at Swarthmore College and Liberty Fencing Club in Warrington.


text:
Table of Contents
This industry data report package offers the most up-to-date market data on the actual market situation, trends, and future outlook for unwrought nickel in different Eastern European countries. The package includes unwrought nickel country reports from the following countries:
Armenia, Bulgaria, Czech Republic, Estonia, Greece, Hungary, Lithuania, Macedonia, Poland, Romania, Russia, Slovakia, Slovenia, Turkey, Ukraine
The reports include historic market data from 2007 to 2013 and forecasts until 2018 which makes the reports an invaluable resource for industry executives, marketing, sales and product managers, analysts, and other people looking for key industry data in readily accessible and clearly presented tables and graphs.
The latest market data for this research include:
- Overall unwrought nickel market size, 2007-2018
- Unwrought nickel market size by product segment, 2007-2018
- Growth rates of the overall unwrought nickel market and different product segments, 2007-2018
- Shares of different product segments of the overall unwrought nickel market, 2007, 2013 and 2018
- Market Potential Rates of the overall unwrought nickel market and different product segments
The product segments discussed in the data reports include:
Alloyed unwrought nickel
Not alloyed unwrought nickel
The reports help answering the following questions:
- What is the current size of the unwrought nickel market in different Eastern European countries?
- How is the unwrought nickel market divided into different product segments?
- How are the overall market and different product segments growing?
- How is the market predicted to develop in the future?
- What is the market potential compared to other countries?
Among the key reasons to purchase include the following:
- Gain an outlook of the historic development, current market situation, trends, and future outlook of the unwrought nickel market in different Eastern European countries to 2018
- Track industry trends and identify market opportunities
- Plan and develop marketing, market-entry, market expansion, and other business strategies by identifying the key market trends and prospects
- Save time and money with the readily accessible key market data included in the report. The market data is clearly presented and can be easily incorporated into presentations, internal reports, etc.
Get Industry Insights. Simply.
The nickel alloys market is projected to reach USD 14.68 billion by 2022 The nickel alloys market is estimated at USD 12.14 billion in 2017 and is projected to reach USD 14.68 billion by 2022, at a CAGR ...
The Nickel Alloys market is poised to grow at a CAGR of around 4.8% over the next decade to reach approximately $17.82 billion by 2025. Some of the prominent trends that the market is witnessing include ...
Global primary nickel output in 2016 fell 1.5% to 1.934 million tons. In 2017, as China's nickel pig iron project in Indonesia reaches design capacity gradually, nickel metal supply is expected to hit ...
Mining And Quar...
United States
Non-Ferrous Met...
United States
North Korea
Mining And Quar...
Reportlinker.com © Copyright 2017. All rights reserved.


text:
Kingsmead Cromarty Super "Sable"
- WOW - Wool Owner's Warranty
- Suitable for Heavy Domestic wear
- 4 and 5 mertre width
- 80% Wool, 20% Polypropylene
- Delivery Charges
- £29.50 per order
- Delivery Time
- 7-10 working days
offer now!
Product characteristics: Kingsmead Cromarty Super "Sable"
|Loop Pile
|Width Available
|4m, 5m
|Pile Material
|80% Wool, 20% Polypropylene
Product features
The luxurious Kingsmead Cromarty is a premium carpet from Kingsmead's illustrious Wool Twist Collection. This luxury carpet is available in 3 weights: Super, Elite, and Luxury. The high quality of the Kingsmead Cromarty carpets comes from being crafted from an 80/20 wool synthetic twist carpet fibre. This combination of extremely durable wool fibres with synthetic fibres, gives this blended carpet fibre an extraordinary amount of durability and resilience. While this carpet is known for its exceptional durability, it is extremely comfortable underfoot and has uncompromising softness. The incredibly soft Kingsmead Cromarty is suitable for heavy domestic use, making it perfect for many rooms in your home. The Kingsmead Cromarty is available in 9 classic colours that are sure to complement the interior of your home. This luxurious carpet line is a worthwhile investment for your home, and comes backed by the WOW- Wool Owner's Warranty Programme. This programme helps maintain your carpet, ensuring it looks great for many years to come. The Kingsmead Cromarty is availabe in 4 and 5 metre widths, making it easy to get a precise fit. This added precision minimizes waste, saving you time and money when fitting. If you are looking for a comfortable, yet stylish and durable carpet collection with options for any budget, then the Kingsmead Cromarty carpet collection is the place to look.


text: A blonde, a brunette, and a redhead all work at the same office for a female boss who always goes home early. "Hey, girls," says the brunette one day, "let's go home early tomorrow. She'll never know." So the next day, they all leave right after the boss does. The brunette gets some extra gardening done, the redhead goes to a bar, and the blonde goes home to find her husband having sex with the female boss. She quietly sneaks out of the house and vows to return home at her normal time the next day. In the morning, the brunette says: "That was fun, we should do it again sometime." "No way," says the blonde. "I almost got caught."


text:
Tired, worn and dated are words many would use to describe the Dunblane Hydro, owned by Hilton Hotels. Due for a refit in late 2009, the hotel is, indeed, badly in need of refurbishment in the communal areas.
The Balmoral restaurant, with the discoloured carpeting and dated decor, serves a staple diet of food which appear to be mass produced for ease of service, rather than any skilful culinary expectation.
Staff were generally friendly and approachable. The cleaners and room servants all stopped to wish you the day's greetings. when you squeezed past them in the narrow corridors outside your bedroom.
The rooms are large with king-size beds and cable TV though you wouldn't expect anything less from a Hilton.
For time-out, try the health spa which is free for residents and provides ample opportunity to unwind from the hours you spent that day venturing the nearby lochs and fells.
All in all, a satisfying stay at the Dunblane Hilton though regular Hilton-goers may be diappointed with the dated feel that this hotel has.
The Dunblane Hydro Hotel is a 4 star hotel, situated in the Perthshire countryside overlooking the historic city of Dunblane. Unfortunately Dunblane is perhaps best known now for the 1996 massacre of 16 young school children and their teacher in Dunblane Primary School, but the history of the town dated back to the around the late 6th century.
The hotel itself is situated on the top of a hill, surrounded by 10 acres of grounds, overlooking the historic town. The building was first opened as the Dunblane Hydropathic Establishment in 1878 to capitalise on the medicinal value of the local spring water. The original hotel contained a number of different types of baths, including Turkish, Russian, vapour, plunge, wave, electric and electro-magnetic baths. At one end of the main corridor was a large drawing room; while at the other end of the corridor was the dining room. The kitchen was on an upper floor, with food being lowered to the dining room by a service lift.
The Hydropathic Establishment did not prove as popular as expected and lasted only a few years. Since then, the hotel has gone through a number of changes, including being a Stakis hotel and a Hilton hotel. I believe that the hotel is rejoining the Hilton brand next year, being a Doubletree by Hilton brand.
Outside the hotel has plenty of parking spaces, including disabled spaces at the main entrance. The entrance to the hotel has a revolving door, with about 10 stairs leading up to the reception area, although there is a small lift that goes to the reception, but this isn't clearly signposted.
The reception is large but poorly staffed at times. The reception staff were friendly and efficient.
The original drawing room is now the Balmoral Restaurant, where delicious meals are served at breakfast, lunch and dinnertime. There is a wide variety of food available at the breakfast buffet, from a full English breakfast, to cereal, toast and fruit. The cooked breakfasts were not in the least bit greasy, and very tasty and fresh tasting.
The dinner menu also has a wide variety of meals available, from fillet steak, to salmon and vegetarian meals. A three course meal costs £22.95 per person, if not included in your room deal.
The original dining room is now a large open space, perfect for meetings and receptions. At the time of my visit, this space was not being used, and had a number of large comfy chairs situated around, and a large log fire burning bright.
Along the main corridor is a coffee shop and cocktail lounge, with a function suite beside the reception area. I believe that the hotel has regular entertainment at weekends, being a jazz band on the Friday night and a céilidh band on the Saturday night.
So, onto the bedroom. As it was a special occasion we upgraded to an Executive Suite. This was a larger room, consisting of a lounge, dining room, bathroom, bedroom with en suite and a dressing room. The suite was immaculate and was in great condition, and appeared to have been recently upgraded.
There was a TV in both the lounge and the bedroom, and the room included an iron and ironing board, and tea making facilities including tea, coffee, hot chocolate, biscuits and crisps. The room also came with a flower bouquet and chocolates.
For a pampering treat, the hotel has an indoor leisure centre just beside the main hotel, with a small pool, Jacuzzi, sauna and steam room, and for the more energetic, a gym. There are also a number of treatment rooms offering aromatherapy, reflexology, facials etc. I didn't make use of the treatment rooms, so can't review them, but the changing rooms were clean and spacious, and towels were provided at reception.
The pool was kept at a good temperature, and the sauna was very warm. The steam room was lovely, with a menthol scent. Outside the sauna and steam room were a number of showers.
The hotel has obviously recently been majorly upgraded, but there are a few areas that still need upgrading, mainly staircases and some corridors. The leisure centre could also do with some work, as despite it being clean, it does look a bit dated.
I especially liked the fact that all the hotel staff seem to be from the local area, which gave the hotel a nice Scottish, homely feel.
This is an expensive hotel to stay at, our room cost about £150 a night including dinner on both nights, and this was a special offer. Drinks within the hotel were also expensive, but if you're looking for somewhere to go for a relaxing weekend, I'd strongly recommend this hotel.
Who could resist staying at this famous and majestic hotel, stunningly situated in over 10 acres of glorious landscaped grounds, on a hill overlooking Dunblane and the surrounding Perthshire countryside? Dunblane is one of Britains smallest cities, as it has a Cathedral, well worth a visit, but sadly Dunblane is remembered for the massacre that happened on my birthday in 1996. A day I wont forget. It was the reason I had celebrated a birthday that I was here though! A time to pamper myself, relax and enjoy retirement.
Easily reached by train from Edinburgh or Glasgow or by good road links we used TOMTOM and he guided as safely to the curved driveway, giving us time to look at the magnificent building as we approached, taking in the scenery on the way. There was plenty of parking, some for disabled too at the front of the hotel, but as this was full we drove on further and parked, noticing even more parking available and a newer block which had been built, which was separate from the hotel. It was a beautiful day and my companion and I trundled our cases enjoying the view, as it was a sunny day we didnt mind, if it had been wet or snowy, not so enjoyable.
*Our Arrival*
No red carpet for us, but it was very new and smart! But the revolving door, wasnt revolving! It took quite a bit of pushing and the space wasnt very big once you had a case inside with you! Certainly the following day it was working again. We were faced with a flight of stairs, as no porters rushed to assist us, we had to carry our own cases! Remember we were here to be pampered!
Reception was very swish, large and spacious but only one member of staff was on duty, after queuing, we were informed our room wasnt ready, as we were early. We had booked through an offer in a local newspaper through Classic Britain Hotel Consortium, it clearly said check in time after 3.00pm. We were informed check in is after 4.00! But that we could stay until 12.00 instead of 11.00am! Perhaps we would like to leave our cases in a room along the corridor and have a cup of tea. We did this, (although it was an unlocked room and anyone could wander in and remove our cases) after discovering the ladies cloakroom, which was very large and had individual towels more the size of a flannel, but lovely to dry your hands on. No paper towels here, although they needed more soap dispensers for the number of wash basins.
The layout was easy to see on this first floor, the Balmoral dining room was at one end, more about this later, and then a small lounge area called the Oak Room. The first night we enjoyed our coffee here, but it was in use for business meetings the second night. The ladies toilets, as mentioned earlier and a help desk, this was being set up at the time, but there was a selection of leaflets available for tourists. Dunblane is in a great area for visiting tourist attractions, especially in Stirling, Callender, Doune, Blair Drummond to name but a few. The main reception desk, which was opposite the stairs still had a queue! There were glass show cases with jewellery and other gifts which were on sale, and we noticed a lift, which we could have used when we entered but there was no sign directing us by the door! There was a small coffee bar and on the opposite side of the corridor was the Cocktail Bar. We sat in the comfortable chairs near a window, but couldnt enjoy the view, as the windows were too high! This was the only place we saw that was in need of refurbishment, we had been slightly worried as someone said the hotel was run down, the lining in the curtains was ripped and could have been tucked from view with a little more care, but it looked as if a great deal of work had been done already.
A pot of tea for two was ridiculously over priced I think it was £5.90! My friend did get a jug of hot water from them later so we managed 2 cups each! We did explore further along the corridor and there was a corridor leading to Conference rooms, a small lift to enable wheelchairs users to go down a level, the Gents which we didnt peep into even for review purposes! and the Stewart Lounge, which on the morning we left, was being used for a meeting. There were stairs cases to the upper levels at both ends of the corridor. There are 4 floors in the hotel.
*The Bedroom*
We had paid a bargain offer price, so didnt expect a luxury room, and were pleased it was in the main hotel rather than the extension block. When we did get our key cards we followed the instructions and went up in the lift to the next floor. And here the trail began we walked along the quite narrow corridor and up several stairs, then turned and walked away from the front of the hotel, down a corridor, down more stairs and eventually we found our room. I realised we were not going to have a view, but hadnt expected it to be frosted glass on the window! OK, stand on chair and try and look out the top of window, not a lot to see apart from a modern metal type of roof and more bedroom windows, so that was a waste of time!
Back to the room, it was basic, it was small, but it was adequate and it was clean and the bathroom was spotless. So do you want to know what there was in the room?
Two single beds, which were very comfortable, there was a white cover on the quilt and a small over blanket in a rather old fashioned brown tweedy/tartan mixture. But the room was warm and the bedding more than enough for March. Two pillows, and an extra gold coloured cushion. The wardrobe was quite old fashioned, double-doored and housed an ironing board and iron, if you felt the need to press your clothes. There were lamps, a television which had good reception, and films could be paid for if you fancied watching an adult movie! The case rack, doubled as a large two drawer unit, again old fashioned dark wood, but nevertheless it was wood, not a modern chipped laminate, as so many hotels now favour. Under the television was the kettle and tea and coffee making necessities. There was just one packet of biscuits with 2 chocolate brownies. Between the beds was a bedside table and telephone and in the corner by the window a dressing table, with wall mirror, and two hair driers. Now dont get excited, as we did! The one didnt work! In the table drawer was some writing paper and envelopes, and bag for laundry if needed. There was a menu if you wanted to order room service and some information on the area. Plus a welcome letter with some basic information and a note at the bottom reminding people that there is a ban on smoking since March 2006 within the hotel and that there is a designated smoking area at the rear entrance. In Scotland we all accept the ban now, but it is necessary to inform people from England or abroad of the rules. A new and comfortable cream leather chair was in front of the dressing table and another leather chair with arms completed the furniture. It did say there was dial up connection for Internet connection, but I hadnt taken the laptop as this was a pamper break.
Oh! I nearly forgot! Left in the one large drawer was a clean pair of jeans, top and sweater! Not my size! Presumably someone had packed and left these to put on to travel and then hadnt changed, but points off to the person who had cleaned our room. The chambermaids from Victorian days were now men from Poland! Changed days.
Our room obviously wasnt suitable for disabled guests, but there are designated rooms.
*The Bathroom*
The bathroom was very spacious compared with the bedroom! There was a lovely modern bath with good powered shower overhead, a toilet and the wash basin was built into black marble, with plenty of room to put your toiletries. Lovely large white fluffy bath towels and hand towels, as you would expect, but and a large BUT, the toiletries were disappointing. Remember this is a Luxury hotel, there was one flannel OK so I dont often use a flannel and had my own, but one flannel in a twin room! There was one small bottle of shower gel and one small bottle of shampoo. Plus one shower cap, again this was a twin room and we were two ladies, and you dont normally share shower caps! Minor annoyances. But annoyances all the same.
The water was always hot, morning or night when we showered and the power level was fine, so no complaints there.
These made up for the minor room problems, and check in wait. We were advised to book for dinner this proved difficult as there was no-one in the dining room when we checked in and no-one answered the phone, when reception tried to do it for us! But the message must have been relayed as they were expecting us when we went down at 7.30pm. Very efficient staff, although very few were local. Polish, Indian and possibly German seemed to be the order of the day. Although there was a Scots accent the one morning in the form of a cheery lady, who seemed to be in charge in the dining room.
We choose our wine having already imbibed in our room we decided on a large glass rather than pay £19 - £20+ for a bottle! My chardonnay cost £5.65 for a 250ml. We choose our menu, were served with lovely warm rolls and didnt have long to wait, when our starters arrived.
Smoked duck breast on a bed of noodles with sesame oil. Absolutely delicious! For main course I had Trout on wilted spinach, with a white wine sauce, red cabbage (shaped in a circle), duchesse potato and some Mange tout. Again delicious. We were given a breathing space before, our waiter brought the dessert menu and although by then I was feeling quite full I managed to eat a light and refreshing Lemon tart with some meringue and crème fraiche. The menu outside the restaurant stated that dinner was £22.95. Not over priced for such a lovely meal, but ours was included in the deal.
Elizabeth Shaw mints accompanied the bill, and more came with the coffee!
A few hours later we were up and sampling breakfast! We were shown to a table and given instructions where we could find everything. I was used to staying in hotels that brought you toast and tea and coffee to the table, but here it was self service! We had to make our own toast and collect our coffee from a little urn. The coffee was fine, but I heard people saying the tea was a bit stewed! There was a flask if you needed hot water and a selection of teabags. There was a cold buffet with bowls of fruit and yogurt, cheeses, a selection of fruit juices, the usual cereals, bread, rolls, Danish pastries and a large hot buffet with the waiter cooking fried eggs as needed, so at least the yolk was how you like it! Not being a cooked breakfast fan, I enjoyed the fresh fruit, but decided to sample the bacon and potato scones. Both were lovely. Butter, spread and jams were on the table, as were milk and sugar.
Children were well looked after and high chairs available, I believe there was an earlier slot for children to eat too at night. The dining room was large and airy and looked as if it had been extended with a conservatory type building. This area was set up ready for lunch, presumably for one of the meetings that was in.
We decided to have a snack lunch from the Coffee bar, but had to order our drinks from the bar. We chose a Coke and I requested Appletise. The young girl, didnt understand, and couldnt find any, she then produced a carton of Apple juice and I said that was OK. But it ran out and she disappeared to get another carton, 5 minutes later she returned! In the meantime another guest returned to the bar, annoyed that she was still waiting for their drinks to be changed as they had been served with a sweet white wine instead of Dry! I feel sorry for foreign staff having to cope on their own, when they very obviously had language problems. The sandwiches arrived, and were delicious!
I did notice that there were a couple of hours in an evening when parents could leave their children and they would be cared for. There was no facility during the day that I noticed on the poster, but it did say there was baby-sitting. There was a small play area at the rear of the hotel near the Leisure centre and of course lots of grass where children could run around.
* The Triangle Leisure Club *
The main purpose of our visit, some pampering! We had a choice of 2 treatments included in our deal. Either a facial, a back, neck and shoulder massage or Aromatherapy.
Quoted from Dunblane Hydros website We have a dedicated, professional leisure team, two of whom are fully qualified gym instructors who will be delighted to design and help you with a fitness programme which suits your specific requirements.
It is advisable to book any spa treatments 2-3 weeks in advance of arrival.
When I received the confirmation booking form from Classic Britain, it said to contact and book the treatments, which I did. I was advised that the Aromatherapy wasnt available as the therapist was on holiday, and although we couldnt have our treatments at the same time, we could have 10.00 and 10.30 and 4.00 and 4.30. But unfortunately they couldnt book us in for more treatments as planned. Two weeks after doing this, a receptionist phoned from The Hydro to say there were no slots available for our treatments, but I explained I had already booked direct, so was pleased I had done so.
The day we arrived we checked out the centre, signed in received a large towel and went and tried out the pool, Jacuzzi, stream room and sauna. We looked into the gym and saw lots of people on running machines and exercising and decided we wanted pampering not hard work. A section of the pool was cordoned off for people to swim lengths, and later we watched some young people doing life saving techniques. There was a shower area beside the pool to use after the steam room and sauna, and some sun beds if you felt like relaxing. The steam room was very modern and nicely tiled with blue mosaic, it was mildly menthol and very hot, I could only stay there a short time, but my skin felt better for it. The sauna was a reasonable size, and had the usual egg timer on the wall. The changing room had about 36 lockers, for which you needed a £1 coin and 3 changing cubicles, one with a changing area for babies. Children under 3 had to wear special swim nappies which were on sale at the desk in reception.
There were only 2 showers, 2 toilets and wash basins. Shower gel was provided and some hand cream beside the washbasins. There was a spin drier and a couple of hairdryers.
In the reception area, swimsuits were on sale and some beauty products, there were tables and chairs were you could enjoy a drink and watch the swimmers. I believe snacks were available but we only had an instant coffee, which cost £1 for a large mug.
Sounds perfect? Yes, BUT! I was surprised to see a greasy looking tidemark on the Jacuzzi on the first day, but it looked cleaner the second day, perhaps they heard me remarking it needed some Cif cleaner! And remember I said, we were there for a bit of pampering. I was celebrating being 60 and my friend was 50 a couple of days before our break. On arrival for our facial we were told the therapist had phoned in sick. We explained that was our reason for going! The young lady was very nice and said they were trying to arrange another therapist. Perhaps we would like to use the facilities and check on the way out! Our faces dropped!
True to word, she managed to arrange another therapist. But, it meant we had to leave our comfy hotel and go down to Dunblane to a salon where one of us would have the 2 treatments originally booked and the other would have an hour long facial. We had mixed feelings, the instructions on how to get there were confused. A client told us we couldnt driver the way the receptionist was showing us on the map, as it was a one way street! Parking could be a problem etc. We had come to relax and be pampered now we were getting stress! But my friend managed to get reception to organise transport for us, and although it was only a short drive, it was not where we understood it to be from the instructions!
The salon therapists and staff were great (if you ever go to Dunblane Hydro and want some pampering try NEROLI!). We met another two ladies who had been fitted in, but only for facials, so they had missed out on their massages. This seemingly is quite a common occurrence. I certainly was disappointed that they had no back up therapists at the hotel, but glad we were fitted in, or the main reason for our break wouldnt have happened.
Because of this I cannot comment on the treatment rooms!
All good things come to an end, and we had to pay our bill! Reception was busy again, the two girls were kept busy. A bill was printed out, and as we both wanted to pay separately it was divided and new bills printed out, chip and pin facilities quickly made a dent in our credit cards, and we were ready to go on our way. The offer we went on through the paper and Classic Britain hotel consortium cost us £135 midweek for 2 nights per person, including dinner and 2 treatments. Drinks and lunch was extra.
Checking on the web site it normally costs about £109 per day per room for B&B plus treatments and plus dinner both nights which adds up to £204.90, so we did get a bargain.
I would think twice about returning if I wanted to be pampered. The meals were great, the room could have been better as there was no view. The staff, although friendly found the English language difficult. The leisure arrangements were the biggest disappointment, and so Im afraid this majestic looking hotel wasnt all it should have been.
Nevertheless I did enjoy my little break and we made up for any disappointment by some retail therapy on the way home!


text: What are you currently watching on Netflix? Post a link to what you are streaming and recommend! Currently catching up on a crime documentary series that I watched on cable a few yrs back: I Almost Got Away With It - If you have a stream account, Click HERE: And Check Out the Episodes Is Your Flix on the Hit List? (Adding hotlinks to the Titles In This List Log Onto Your NETFLIX Account to watch Instantly) Spoiler Others Are Watching 24 *Added Dec 3, 2013! 30 Rock Alice In Wonderland (*ORIGINAL*) Arrested Development ATM Behind Mansion Walls *BREAKING BAD* Buffy - Vampire Slayer Burn Notice Cat Run Derek Dollhouse Family Guy *Added Dec 2 2013! Farscape(episodes) Firefly (episodes) Frasier: Futurama Goats Headhunters House Of Cards How I Met Your Mother I almost Got Away With It It's Always Sunny in Philadelphia Kingdom Klown Law & Order Lillyhammer Merlin *NEW EPISODES 7/2013* Mythbusters Oddities Orange Is The New Black *NEW 7/2013* Person Of Interest Portlandia Reno 911 (6 Seasons) Saving Grace (Episodes) Scandal ( Jooseyyy ) Scenic Route (thriller!) Scrubs Solomon Kane (link will be added later) Star Trek Star Trek: The Next Generation: Supernatural (episodes) Swingers The Office (U.S.) The 4400 Trailer Park Boys Workaholics NEW SHOWS COMING TO NETFLIX 2017! Spoiler Arrested Development (Coming in May 2017) **RICO AND THE RESTLESS*** (Coming SOON)


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BMW 5 Series Carpet Floor Mats 528i 535i 550i xDrive (2014+) - Vento Beige Description
Designed specifically for the BMW 5 Series from 2014 onwards, these BMW floor mats will instantly spruce up your interior. The set of 4 mats are precision-cut with a special Velcro retention system to hold them in place and are made to match the carpet color of your BMW, resisting water and staining while adding cushioned comfort.
- Velour carpet matches vehicle interior carpet texture, preserving a factory appearance
- Unique 6.6 nylon fiber repels soil and stains to maintain a neat and clean interior appearance
- Meticulously crafted to wear well and retain a like-new appearance, even after repeated vacuuming
- Tighe-pile construction creates a smooth surface that helps keep soil from penetrating the fibers
- Densely woven heel pad offers a soft platform for heels; protects shoes from being scuffed
- BMW lettering on driver's heel pad
Additional Information
|Part No.


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CLERMONT - Each year Camp Crooked Creek plays host to unique activities for children who ordinarily do not receive such an opportunity.
If you currently subscribe or have subscribed in the past to the The Pioneer News, then simply find your account number on your mailing label and enter it below.
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Posted 7 years ago
(9 items)
Another house find, this appears to be a M Nimmo Moran Etching, which the first two photos are of the cover sheet, and the third photo is the etching. Just wondering if this is an original, it looks like it is, but any help or input would be nice. Thank you.


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ĀHAMILTON >> The Utica Zoomobile brought in some slimy, scaly friends Feb. 21 to teach kids at Colgate Bookstore the difference between frogs and toads as well as amphibians and reptiles. The kids were assured these toads wouldn't give them warts.
The Frog and Toad Program started out Thursday, Feb. 21 with stories. Children's Program Director Heather Elia read "Frog and Toad Adventures" as well as "999 Frogs wake up" and "Toads on Toast." After the reading, Education Assistant Cathleen Mallory and volunteers Cory McKimstry and Kendall Carmody brought in some animals from the zoomobile to show to the kids.
John the American toad, Veruca the African bullfrog, Ira the Burmese python and Terry the diamondback terrapin were all brought in to show the kids the differences between amphibians and reptiles.
"Amphibians spend half their live in water and half their life on land," said six year old Aoife Douglas who was happy to answer Mallory's questions.
"Amphibians have to stay wet in order to survive," Mallory said to the kids. "John has little bumps on his back that store water while Veruca has sticky skin to help trap water."
Mallory and her assistants let the kids touch each of the animals, but told them to careful and avoid their faces and only touch lightly so they don't hurt them. While the animals were being shown, Mallory told them more about the animals.
John was found at the Utica Zoo in the old bear enclosure where zoo staff rescued him. In addition to the sacks on his back that store water, John also has two venomous sacks that he discharges when he thinks he might be eaten.
Seven year old Christopher Markowski said he really liked getting to meet the amphibians and reptiles at the bookstore, and learned that frogs like to hop.
"I learned that some snakes aren't venomous," said eight year old Harry Rosbrook. "Toads keep water in sacks on their backs and they have venom that makes it so they don't taste very good."
Mallory said that the group shows animals often throughout the year and programs range from young kids to adults.
"With kids, we focus an easy things like visible differences and easy stuff," Mallory said. "When we teach adults though, we explain that some species are endangered or invasive."
While none of the animals they brought into the bookstore are on the endangered list, recent weather changes and diseases of significantly impacted frog and toad populations in other parts of the world. Mallory explained that Burmese pythons like Ira are considered an invasive species and are a nuisance in places like Florida.
The zoomobile visits the bookstore twice a year. The last time they were there, they showcased species that are native to New York State like the porcupine. Topics range from climate and ecosystem to simpler things like the starring animal in a children story.
Elia said that the next program at the Library will be a Dr. Suess presentation in honor of his 109th birthday on March 2 at 10 am.


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TEENAGER Dominic Marie, a striker, has signed for Skrill Premier play-offs contenders FC Halifax Town from Winsford United.
The front man, on target for Blues three times this season in the North West Counties League, has impressed manager Neil Aspin while training with the Shaymen over the past few weeks.
He will spend the remainder of the campaign on loan with Blues.
Marie, 18, makes the same switch as Lois Maynard last summer.
The versatile defender has been a regular in the starting line-up during Halifax's return to non-league's top tier, amassing more than 30 starts in league and cup.
Midfielder Jake Hibbs has joined Winsford on loan from Halifax as part of the arrangement.


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Category: baby name Giada
Though the season of justifiable stuffing our faces is finally officially past, that doesn't mean we have to stop thinking about food. So let's take this opportunity to sublimate by saluting some of the most famous foodies of the past and present. Of course, the Nameberry accent is on those with particularly noteworthy names—so, with apologies to Julia, Jamie, Jacques, Mario, Alice, Anthony, Daniel, Bobby and Gordon— here are our Top Chef choices.
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You Axed for It...
To commemorate both the upcoming television premiere of Axe Cop (July 21, 9:30pm, on Fox) as well as Mezco's Summer Exclusive Axe Cop Badge prop-replica, Mezco will be hosting a special signing by the Axe Cop creators at San Diego Comic-Con.
On Friday, July 21st, from 12noon-1pm, both writer, 8-year-old Malachai Nicolle, and artist Ethan Nicolle, will appear at Mezco's booth #3445 to sign Mezco's Summer Exclusive Axe Cop Badge prop-replica (pictured below). This will be their only scheduled autograph signing at SDCC.
Axe Cop was originally created when (then) 5 year old Malachai told his older brother, Ethan, the story of Axe Cop one day while playing. At the time, neither of the brothers ever imagined Axe Cop would grow into a cultural phenomenon comprised of a popular website, best selling graphic novels, a cartoon, and action figures.
The packaging for the badge was designed specifically for this autograph event and includes a spacious autograph area. The badge is available for $5 at the Mezco booth or for the same price online at mezcotoyz.com (online badge is not autographed).
There will also be a limited number of Wexter Plush and Avocado Soldier Plush available for purchase at the Mezco booth.
During the show, Mezco will also be revealing the line up for Axe Cop Series 2 action figures. Series 2 will include fan favorite characters:
- Baby Man
- Axe Cop in Cat Suit
- Candy Candy
- Axe Cop from President of the World Comic
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, AlterEgoComics.com, PlasmaInfusion.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


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A borrored coin is marked and placed under a handkerchief. Suddenly the coin vanishes. Magician then introduces a small wooden box that is securely locked with a small padlock. The spectator is given the key and asked to open the box. Inside is the marked coin! Comes with the box, lock and instructions. Use your favorite method to vanish the coin then reproduce it from the locked container.
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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Sarcoid effect on the eyes
Can Sarcoid change the eye color of a female?
Dear Sir/Madam- Sarcoidosis can cause inflammation in almost any part of the eye, including the nerves sending signals to and from the eye (optic neuritis), the back of the eye (posterior uveitis), the front of the eye (anterior uveitis) and the outer protective membrane of the eye (conjunctivitis).
Although the colored part of the eye (iris) is usually not directly affected by sarcoidosis, it is possible that inflammation in the anterior chamber of the eye (anterior uveitis) could change the appearance of the iris due to the presence of particles in the fluid in the anterior chamber of the eye causing a "cloudy" appearance.
If you have sarcoidosis involving the eyes, close monitoring by an ophthalmologist (eye doctor) is recommended to avoid serious complications, including vision loss and glaucoma.
Elliott D Crouser, MD
Associate Professor of Pulmonary, Allergy, Critical Care & Sleep Medicine
College of Medicine
The Ohio State University


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I received a sample of this product to facilitate my review. All opinions expressed are my own.0
Here at This Mama Loves Her Bargains, we are always on the lookout for cute, fun, creative AND environmentally friendly products. Well, we've got a great one for you today. Tili Bags. These things seem to be popping up everywhere, and for good reason. They're fantastic! I first saw these bags while I was perusing an issue of InStyle Magazine at the salon. The flashy colors instantly caught my eye.
Let me tell you a little bit more about Tili Bags:
1. These are plastic storage bags with zip top closures
2. They are made out of a thick plastic (much more durable than your typical plastic storage bag)
3. The bags come in 3 color schemes: Purple, Blue and Orange/Yellow. Each box of bags comes with 3 different patterns.
4. Each box contains 12 Tili Bags.
5. These bags can easily be washed and rinsed, so they can be used over and over again
Wow, where to begin. These bags are so versatile. They can be used for makeup, general organization, snacks and camp gear. Each bag has a section for labeling, making them the perfect camp solution. Not only will your child's belongings/snacks stand out from everyone else's, but you can label them and use them over and over again. Simply rinse them out at the end of the day and use again. I have used them on picnics and for packing swimming gear. They have proven to be very durable after multiple uses. I can easily recognize my items and nothing gets lost in the shuffle.
Tili bags are being sold on the largest summer camp supply company website in the country (as well as in select retailers in CA, WA, NM, CO, TN, GA, TX and FL)
Tili bags have recently been featured in several magazines:
*Redbook lists tili bags in its 50 products under $50.
*Rachael Ray picked tili bags as an everyday fave!!!
*Also seen in InStyle
If you are looking for a stylish and unique way to tote summer essentials and for organizing around the home, Tili Bags are the way to go. They come in fun, funky patterns and colors and can be used over and over again. We just love these bags and use they all over the house!
Tili Bags have become a camp and picnic essential in our house. My little ones just love picking out their own color and pattern for the day, and they feel extra special that they have their very own designer bag to take with them.
Follow Tili Bags on facebook for the latest on product information and promotions.
Tili Bags retail for $8.49 for the gallon sized bags and $7.49 for the quart sized bags. They can be purchased here online.
super cute! I like the fact you can use them over and over
Yay for cute reusable bags! And at a great price too!


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Our Wines
What's New
2010 Cicinis Collio DOC
Wine Spectator, 90 pts, September 2013
The Attems family winemaking lineage dates back nearly a millennium
. In 1106, records show that the Bishop of Salzburg gave them the estate for the purpose of cultivating vineyards and making wine.
After 900 years of wine production, Attems aligned with the renowned Marchesi de' Frescobaldi, one of Italy's most revered wine families
. Douglas Attems and the Frescobaldi family celebrate a legacy of friendship founded during their years as students at the University of Florence. Understanding that a wine's quality and personality reflect the land it comes from, they have pledged to further enhance the vines at Collio. Together they have committed to innovative vineyard development and to strategic participation in the global market.
The Attems vineyard's marl and sandstone soils known as "ponca" produce crisp and lively Pinot Grigios and Sauvignons.
In northeast Italy, bordered by the Alps to the north and the Adriatic Sea to the south, lies the Attems estate in Collio. This estate soil, a sandy, clay marl, is firm to the touch and rich in minerals and microelements. This soil produces beautiful food wines with the structure and acidity to deftly pair with a wide variety of foods.
Sip the wines of Attems and taste a millennium of winegrowing tradition.
Inside Attems
Cupra Ramato
The wines are remarkably expressive, displaying intense aromas and distinctive varietal characteristics, cleanly delineated and firmly structured.
Pinot Grigio
The appearance is that light, copper-tinged yellow-gold classic to the pinot grigio variety. Ripe tropical fruit adorns the nose, complemented ...
A luminous straw yellow, with subtle greenish highlights announces this wine. The nose is rich and dense, with lovely elderflower ...
This wine is well-fruited, and the classic minerally quality is in exceptional balance with the full body characteristic of the ...
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2012 Attems Sauvignon
JamesSuckling.com 90pts July 2013
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A Multi-center, Prospective, Randomized Study With PriMatrix and PriMatrix Ag for the Treatment of Venous Leg Ulcers
This study has been terminated.
(Site selection)
Integra LifeSciences Corporation
Information provided by (Responsible Party):
Integra LifeSciences Corporation
ClinicalTrials.gov Identifier:
First received: June 4, 2012
Last updated: August 7, 2017
Last verified: August 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
To evaluate the effectiveness of PriMatrix, PriMatrix Ag, and Standard of Care in the treatment of venous leg ulcers (VLUs).
|Venous Stasis Ulcer
|Device: PriMatrix Device: PriMatrix Ag Procedure: moist wound therapy
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Multi-center, Prospective, Randomized Study With PriMatrix Dermal Repair Scaffold, PriMatrix Ag Antimicrobial Dermal Repair Scaffold, and Standard of Care for the Treatment of Venous Leg Ulcers
Resource links provided by NLM:
MedlinePlus related topics: Leg Injuries and DisordersU.S. FDA Resources
Further study details as provided by Integra LifeSciences Corporation:
Primary Outcome Measures:
- Percent of VLUs healed by week 12 post-randomization [ Time Frame: 12 weeks ]
Secondary Outcome Measures:
- Cost of treatment [ Time Frame: 12 weeks ]
|Study Start Date:
|June 2011
|Study Completion Date:
|February 2017
|Primary Completion Date:
|February 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: PriMatrix
PriMatrix Dermal Repair Scaffold
Device: PriMatrix
fetal bovine dermal scaffoldProcedure: moist wound therapy
standard of care moist wound therapy
Experimental: PriMatrix Ag
PriMatrix Ag Antimicrobial Dermal Repair Scaffold
Device: PriMatrix Ag
fetal bovine dermal scaffold with AgProcedure: moist wound therapy
standard of care moist wound therapy
Active Comparator: Standard of Care
Standard of Care Moist Wound Therapy
Procedure: moist wound therapy
standard of care moist wound therapy
Detailed Description:
Healing percentages
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Men or women ≥ 18 years of age
- Ankle-brachial index (ABI) > 0.80
- Study wound 2-64 cm2 surface area
- Wound does not exhibit a greater than 50% reduction in surface area during the screening period
Exclusion Criteria:
- Suspected or confirmed signs/symptoms of wound infection
- Hypersensitivity to bovine collagen
- Body Mass Index (BMI) ≥ 45
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01612806
Please refer to this study by its ClinicalTrials.gov identifier: NCT01612806
|Puerto Rico
|Caribbean Clinical Trials
|Hato Rey, Puerto Rico, 00918
|Dr. Pila Metropolitan Hospital Wound Healing Center
|Ponce, Puerto Rico, 00717
|Doctors' Center Hospital of San Juan
|San Juan, Puerto Rico, 00918
|Wound and Ulcer Care Clinic of San Juan
|San Juan, Puerto Rico, 00918
|Wilma N. Vazquez Hospital
|Vega Baja, Puerto Rico, 00694
Sponsors and Collaborators
Integra LifeSciences Corporation
|Study Director:
|John Starinski, DPM
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Integra LifeSciences Corporation
|ClinicalTrials.gov Identifier:
|NCT01612806 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 4, 2012
|Last Updated:
|August 7, 2017
Additional relevant MeSH terms:
Leg Ulcer
Varicose Ulcer
Postphlebitic Syndrome
Postthrombotic Syndrome
Pathologic Processes
Skin Ulcer
Skin Diseases
Varicose Veins
Vascular Diseases
Cardiovascular Diseases
Peripheral Vascular Diseases
Venous Insufficiency
Venous Thrombosis
Embolism and Thrombosis
ClinicalTrials.gov processed this record on September 21, 2017


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Topic: Update on John
Hi everyone,
I'm so sad today. I weighed John again and he's down to 156 from 162 a week and a half ago.
We don't see his oncologist again until the 7th. He has a CT scan on the 6th.
He has his birthday the 17th. I really don't think he's going to survive through the month.
This morning at 6 am he got up and looked so sad I went to hold him in my arms and could feel every one of his ribs, and his collar bone. His tushy is gone. We had to get a memory foam mattress because he can't stand the pressure of the regular mattress on his bones and skin.
He's not sleeping through the night due to pain and he's having the same dream every night. He's trying to fill the pickup with all our stuff to move to Alabama and there's never enough time. I think he knows there's not any time left and it's absolutely breaking my heart. I tried to tell him that God might be sending the same dream to tell him to get everything in order since there might NOT be any time left. I don't know how I'm going to survive without him. I love him so much and I know he's going to Heaven but I want him with me.
What do I do for him? I want him to talk to a preacher, I think it will give him a sense of peace for what is coming. I want him to not be afraid about what is ahead of him but he doesn't want that. I wish I could take his fears and sense of uncertanty on myself but no matter who is there, we all have to walk that last step alone. Just pray for him, ask God to send his Angels to guide him home and pray for me ,that I am able to give him my strengh with a smile and a sense of peace for the coming trial ahead.
Thank you all for always being here for me. I will let you know when he is gone. I love each and every one of you like my own family and for your help I pray for a beautiful home on the other shore.


text:
What happens to Alex Smith now that Colin Kaepernick is the San Francisco 49ers' starting quarterback?
Well, there's certainly a scenario in which he stays with the Niners — especially if Kaepernick falters down the stretch. But there's a growing possibility that Smith — who is owed a $7.5 million bonus April 1 — will be looking for a new employer in the offseason.
And just to make things more interesting, what if offensive coordinator Greg Roman is shopping his services at the same time?
There are several teams that could use a head coach-QB package, including Kansas City and Arizona. The Chiefs would be the best fit considering Roman's affection for strong running games and Smith's steady-hand style.
But Arizona definitely would be the most compelling. After all, Smith would get the chance to prove to coach Jim Harbaugh — twice a season — that he made the wrong choice at quarterback. — Matt Barrows
AFC East
Buffalo Bills: Coaches made the right decision in naming C.J. Spiller the starting running back. Spiller's league-leading yards per carry of 6.7 is simply too good for coach Chan Gailey to ignore.
Fred Jackson, who has been splitting time with Spiller, is a perfect fit as a third-down back who can offer a change of pace. Spiller, though, has game-breaking potential, and Gailey has to find a way to get the ball in his hands at least 20 times per game. If that means playing Jackson and Spiller together, Gailey shouldn't oppose it.
The more the Bills can use their two best offensive weapons, the better it will be for the offense. — Jay Skurski
Miami Dolphins: Ryan Tannehill has seven touchdown passes, his passer rating is an unimpressive 72.3 and the 5-6 Dolphins probably aren't going to make the playoffs. But Tannehill took a big step forward in his development as a franchise quarterback last week, which should make Dolphins fans excited about his future.
Tannehill led Miami to 17 points in the fourth quarter in the comeback win over Seattle. It was his first fourth-quarter comeback victory ever, including college. If Tannehill can learn how to close out games, the Dolphins will become dangerous. — Ben Volin
New England Patriots: The team is about to cruise to its 10th AFC East title during the Bill Belichick era, but the real test lies ahead. When the Patriots return from Miami, they will begin to prepare for the first of back-to-back games against two of the NFL's best teams: Houston and San Francisco. Each opponent has a standout defense, and in recent years holding the Patriots to four touchdowns or fewer has generally been a formula for victory.
New England is 5-8 in games in which it scored 28 points or fewer since 2010, including Super Bowl XLVI. The team could all but wrap up the division Sunday, but there's hard work on the horizon. — Shalise Manza Young
New York Jets: Coach Rex Ryan is sticking with QB Mark Sanchez despite Sanchez's penchant for committing turnovers at the worst possible times. Sanchez likely will run a conservative game plan Sunday against offensively challenged Arizona, much like he did in the Jets' win over St. Louis — a game in which he was turnover-free.
The problem is that when Sanchez is asked to do more against stronger opposition, he is unable to do so — and he begins making mistakes. Counting playoff games, he has 64 NFL starts. But the light bulb has yet to go on, and it appears that it never will for him.
Sanchez was a fifth overall pick in 2009, and quarterbacks drafted that high are expected to be much more than game managers. That is all Sanchez is under the best of circumstances these days. — J.P. Pelzman
AFC North
Baltimore Ravens: If outside linebacker Paul Kruger continues to develop, the Ravens might have a good pass rush heading into the playoffs. Kruger has four sacks during the past three games and is giving the defense a threat opposite Terrell Suggs.
Coaches tried to convert Kruger into an every-down player earlier this season, but they had so much depth on the outside that they decided to use Kruger just in pass-rushing situations. Since making that move, Kruger has been keeping constant pressure on quarterbacks.
Earlier in his career, Kruger was just a speed rusher. Now he has good lateral movement and works well with his hands. — Mike Preston
Cincinnati Bengals: After back-to-back 100-yard games from BenJarvus Green-Ellis, the running game could be in for tough sledding on Sunday against a Chargers defense that is tied for fifth against the run.
With San Diego's secondary expected to focus coverage on A.J. Green, this could be a game where other members of the receiving unit step up. Fifth-round pick Marvin Jones looked like he would make a contribution before a Week 7 knee injury. With Mohamed Sanu possibly out for the season after breaking a foot in practice, Jones could get another chance Sunday. — Joe Reedy
Cleveland Browns: It's less important for the 3-8 Browns to steal a few more wins than it is to hone elements for 2013. Eric Mangini's four-game win streak in 2009 brought a final record of 5-11 and arguably hurt more than it helped. Mangini was retained for another season before being fired, and the franchise lost a year of potential progress under a new coaching staff.
Owner Jimmy Haslam should demand the rest of 2012 be focused on components for the future. Running back Trent Richardson is being used too much. There's no sense in further beating up a running back who can be a star when the games count at the start of next season. — Steve Doerschuk
Pittsburgh Steelers: Pro Bowl center Maurkice Pouncey at left guard? There's a good chance that will happen Sunday for the rematch against the Ravens. And that might not be the only move for an offensive line that has lost two right tackles to injuries.
With left guard Willie Colon out and his status unsure for Sunday's game, Pouncey lined at left guard in practice and will play there if Colon is unable to go. Pouncey would be replaced at center by Doug Legursky.
That's not all. Rookie Kelvin Beachum is expected to make his first start at right tackle for Mike Adams (ankle), but he could be bumped if the coaches decide to move right guard Ramon Foster to right tackle and insert David DeCastro at right guard. DeCastro has been activated from the designated to return/injured list.
All the shuffling might not be a good thing for Charlie Batch. — Gerry Dulac
AFC South
Houston Texans: Sunday's game at Tennessee will be their third in a row against a team with a losing record. If the defense continues to play badly until early in the fourth quarter of games, the Texans are going to fool around and lose. If the defense plays the way it's capable, the Texans will improve to 11-1 and clinch a playoff berth. They can't continue to tempt fate after overtime wins over losing teams the past two weeks.
The Texans must obliterate the Titans the way they did in Week 4 at Reliant Stadium, a 38-14 whipping, and last season at LP Field, 41-7. Teams with designs of winning the Super Bowl don't make a habit out of playing down to the competition as the Texans have done the past two weeks. — John McClain
Indianapolis Colts: GM Ryan Grigson turned over every rock and explored every option while piecing together his secondary. We'll see Sunday in Detroit if it was enough.
The Lions' pitch-and-catch combo of Matthew Stafford and Calvin Johnson is one of the league's most effective. On the surface, the Colts' collection of corners doesn't measure up.
Vontae Davis probably could hold his own if he hadn't missed the past month with a sprained left knee. He could return to the starting lineup Sunday but figures to be rusty and might need an occasional blow after missing so much time. The secondary isn't going to stop Johnson, but it must keep him from going off. — Mike Chappell
Jacksonville Jaguars: It's rare that an accomplished pass rusher becomes available at a relatively bargain price this late in the season, which explains why the Jaguars jumped at the chance to claim former Eagles defensive end Jason Babin.
Babin will cost the Jags only $1.64 million in salary the rest of this season, and the team has the option to pick up his $4.625 million cap number in 2013. It can cut Babin at any time without being on the hook for more money, so it's a low-risk move.
The Jaguars are tied for the league's worst pass rush (13 sacks), so they couldn't pass on a quarterback hunter who has 36 sacks since 2010. Babin could start Sunday at Buffalo. — Gene Frenette
Tennessee Titans: After coach Mike Munchak fired offensive coordinator Chris Palmer earlier this week, a question immediately surfaced: Is defensive coordinator Jerry Gray next?
Not right now. But Gray is likely coaching for his job in the final five games. The Titans are 4-7, and Gray's defense has been a big part of the problem. The Titans are 29th in total defense and 31st in points allowed. In seven of the 11 games, the Titans allowed at least 30 points.
Gray's defense is filled with youngsters, especially at linebacker. But an experienced secondary has been getting lit up all season. Gray must find answers down the stretch. — Jim Wyatt
AFC West
Denver Broncos: Peyton Manning and his receivers should rack up yardage Sunday against Tampa Bay's defense, which is last against the pass. But whether the Broncos extend their win streak to seven will depend on whether they can avoid mistakes that remain a stubborn issue during their surge.
The Buccaneers are third in the league with 16 interceptions, and Manning threw four picks in the past four games, helping extend the Broncos' streak of consecutive games with a turnover to 18 (including playoffs). — Andrew Mason
Kansas City Chiefs: It's not as big a need as quarterback, but the Chiefs must add a fast wide receiver in the offseason. Opponents are pressing their receivers without fear of getting beat deep.
The offense has 17 pass plays of 20 yards or longer in their past nine games, and many of those have been catch-and-run plays. In comparison, their opponents have 31 of those plays. The lack of big plays is a big reason the Chiefs are last in the league in scoring.
The Chiefs might get improvement from younger receivers like Jonathan Baldwin and Devon Wylie, but they shouldn't count on it. — Adam Teicher
Oakland Raiders: Team officials are taking a hard stand on middle linebacker Rolando McClain — they gave him a two-game suspension Friday — in light of a recent incident that compelled coach Dennis Allen to banish McClain from practice on Wednesday and Thursday.
This was Allen's chance to show he is in control of the team and won't be intimidated by any situation. Standing up to McClain was something former coach Hue Jackson failed to do last season. Allen might lose an underperforming player, but he will gain plenty of respect from his players and fans. — Steve Corkran
San Diego Chargers: It's now or never for the Chargers. A stretch of six losses in seven games has all but deep-sixed their season. Sunday at home against the Bengals (6-5) is a must-win game if the team is to have any hope of salvaging the year.
At 4-7, San Diego is two games back of forcing a wild-card tiebreaker. It can close the gap to as narrow as one with a win and a Steelers loss. The Chargers face Pittsburgh next week. If the Chargers are to get their season back on track, they'll have to do so without two defensive starters. Safety Atari Bigby (groin) is out for the season, and inside linebacker Donald Butler (groin) isn't expected to play. — Michael Gehlken
NFC East
Dallas Cowboys: Quarterback Tony Romo will likely claim the team record for touchdown passes Sunday against the Eagles. He enters the game tied with Troy Aikman at 165.
Romo will likely own all Cowboys passing records before he is done. But none of it will matter if he doesn't have any playoff success. Aikman was part of three Super Bowl winners; Romo has won one playoff game. If he doesn't get on a roll and help the Cowboys finish strong in 2012, it will be another lost season despite the stats he is putting up. — Clarence Hill
New York Giants: With No. 2 back Andre Brown (leg) out for the season, it is incumbent on top back Ahmad Bradshaw to have a strong closing run.
Bradshaw has not had the season he envisioned for himself, as injuries have limited him to 733 rushing yards and five touchdowns. Still, he is considered one of the toughest and most competitive players on the roster and has not been overworked. He usually only practices once a week to save wear and tear on his feet, and he insists he feels strong and fairly fresh for the stretch run. — Paul Schwartz
Philadelphia Eagles: Two guys who should feel on the hot seat right now are defensive tackle Cullen Jenkins and cornerback Nnamdi Asomugha. Those two, along with Jason Babin, were the three marquee free agents signed after the lockout in 2011 to get the Eagles over the Super Bowl hump. The team has instead gone 11-16 since and recently cut Babin.
Asomugha hasn't come close to fulfilling the monster contract he signed, and Jenkins' play has fallen off. Each could be deemed expendable if the front office desires to send another message, which could happen if the Eagles are embarrassed on national TV against Dallas. — Geoff Mosher
Washington Redskins: The defense is plagued by recurring issues, and a two-game winning streak hasn't changed anything. The Redskins still surrender big plays, which is how Dallas climbed back into the game from a 25-point deficit. And they still don't generate enough pressure. They held Philadelphia to six points two games ago, but that's the only time all season they has held a team below 21.
If the Redskins want to keep playing meaningful games in December, as they will Monday night against the Giants, their defense must continue to cause turnovers. They will struggle to stop teams any other way. — John Keim
NFC North
Chicago Bears: For years — maybe even decades — the Bears have struggled to get a wide receiver and a quarterback who could make the offense more diversified and less predictable.
And talk about ironies, now that they finally have that quarterback and that receiver, they are trying to figure out how they can be more diversified because everyone knows they're going to throw to Brandon Marshall.
Marshall leads the team with 81 receptions. Earl Bennett — the wide receiver with the second-most catches — has 22. — Gene Chamberlain
Detroit Lions: Jeff Backus has taken plenty of criticism in his 12-year career, some deserved. He played on losing teams for 10 seasons and has had difficult years at left tackle.
Now in the twilight of his career, it's time to pay the perennially underappreciated Backus respect. He started 186 consecutive games before a hamstring injury knocked him out last week. Backus could return Sunday against the Colts, but his biggest contribution this season has been behind the scenes getting rookie Riley Reiff ready to one day replace him. Backus is a consummate professional. — Dave Birkett
Green Bay Packers: It might be time to make another change in the offensive line. The coaches moved left guard T.J. Lang to right tackle, but it isn't working. Lang is a gamer and has plenty of talent, but his best position is guard. He should be playing at left guard, so that center Jeff Saturday can be protected by two big guards, Lang and Josh Sitton.
At right tackle, the best choice might be rookie Don Barclay, an undrafted free agent who made the team based on potential. He's probably not physically ready, but at this point they would only have to give him help instead of having to worry about giving Lang, Saturday and left guard Evan Dietrich-Smith help. The Packers might as well try it out because what they're doing now isn't working. — Tom Silverstein
Minnesota Vikings: Percy Harvin's lingering ankle sprain should be remembered well into the offseason just in case there's any hesitation by the Vikings to make anything but receiver their No. 1 priority for an upgrade.
Harvin has missed the past two games and was looking doubtful for a third consecutive week. Without him, the Vikings have no passing threat outside of tight end Kyle Rudolph. And even with Harvin, the Vikings have no dependable vertical threat. Jerome Simpson was supposed to help in that area, but his disappointing 13-catch season reached its lowest point when he dropped three passes in the loss to the Bears.
The receiving corps is so bland that the team could purge its roster of every receiver except Harvin and be just as good with replacement players. — Mark Craig
NFC South
Atlanta Falcons: The team might have exorcised one of its evil demons — the Saints — but the jury remains out. Thursday's uneven game against New Orleans will not likely win over fence-setters.
The Falcons jumped out big but couldn't blow out the Saints. The running game flashed momentarily and then disappeared. The passing game was effective for a while, but then went cold.
The really good teams perform at high levels for extended periods. The Falcons haven't put together any great games. They play great for a quarter and a half, lose their momentum and end up cobbling together enough plays to win. That formula is successful in the regular season but must be rectified if the Falcons expect to finally make noise in the playoffs. — D. Orlando Ledbetter
Carolina Panthers: Even if the team matches last season's 6-10 record, it likely won't be enough to save coach Ron Rivera's job.
Owner Jerry Richardson, with help from consultant Ernie Accorsi, is seeking a new general manager after Richardson fired Marty Hurney in October. At the time of Hurney's dismissal, Richardson told Rivera the team had to be "trending upward" for Rivera to return. Winning four of the final six games would be a good finish. Winning all six is probably the only way Rivera gets a third year.
And with a new GM, even that's no guarantee. — Joe Person
New Orleans Saints: The Saints won't throw in the towel on the 2012 season just yet — not with the mathematical hope of reaching the playoffs at 9-7. But they recognize that they blew a huge opportunity with Thursday's error-filled 23-13 loss at Atlanta.
Nobody was harder on himself than quarterback Drew Brees, who threw a career-high five interceptions. Obviously no one is concerned about Brees being a detriment from this point forward. But he has admittedly battled the tendency to press and try to do too much during dire circumstances this season. And that was especially the case over the past two games. — Mike Triplett
Tampa Bay Buccaneers: With all due respect to running back Doug Martin, weakside linebacker Lavonte David has been the Bucs' best rookie. David took over the play-calling duties, but that has not slowed him or kept him from making impact plays. He leads the Bucs in tackles and tackles for loss and has been solid in coverage.
David already looks like the best linebacker prospect the team has had since Derrick Brooks, and he hasn't found his comfort zone. Martin has made a big impact and will get his share of accolades, but David has been the more consistent playmaker. — Roy Cummings
NFC West
Arizona Cardinals: Coaches hoped veteran Todd Heap would provide a receiving threat at tight end — something that had been missing for years — when the team signed him before the 2011 season. But it's Heap who has been missing for most of the past two seasons. He's played just 12 games over two years because of injuries: a hamstring a year ago and a knee this season.
Heap is healthy now, but he was inactive last week and it's hard to see him getting much time the rest of the way. Rob Housler, a second-year player, has passed him. At 32, Heap could be at the end of his career. — Kent Somers
St. Louis Rams: It has been a season of ups and downs, of progress sprinkled with inconsistency. And now, after ending a five-game winless streak with a 31-17 victory at Arizona, the Rams get another crack at the mighty 49ers.
Three weeks ago in Candlestick Park, the Rams outplayed the 49ers but squandered a 14-0 lead in what ended up as a 24-24 tie. Still unbeaten in the NFC West at 3-0-1, the Rams get another crack to topple the 49ers at home. A victory Sunday would represent significant progress for coach Jeff Fisher's rookie-littered roster. — Jim Thomas
Seattle Seahawks: Defensive end Red Bryant is the anchor of the run defense, and because he has been bothered by a sore foot the past month, the Seahawks have lost their footing against the run.
The team gave up 62.8 yards rushing per game in September, 107 in October and 172 in November. Bryant had not practiced this week and is a big question mark for Sunday's game at Chicago. If he doesn't play, Alan Branch will move from tackle to end. Coaches must find a way to improve the run defense, which has gone from being a strength to a liability. — Danny O'Neil


text:
A Pharmacokinetic Study to Assess Nevirapine [Viramune] Levels in HIV Infected Patients With Impaired Hepatic Functions
This study has been completed.
Boehringer Ingelheim
Information provided by:
Boehringer Ingelheim
ClinicalTrials.gov Identifier:
First received: September 2, 2005
Last updated: November 4, 2013
Last verified: November 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The objective of this study was to evaluate the steady-state clearance of nevirapine among HIV-1 positive patients with hepatic fibrosis, and to examine whether the degree of hepatic impairment influences clearance.
|HIV Infections Hepatic Insufficiency
|Drug: nevirapine
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Pharmacokinetic Study to Assess Nevirapine Levels in HIV-infected Patients With Impaired Hepatic Function
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: NevirapineU.S. FDA Resources
Further study details as provided by Boehringer Ingelheim:
Primary Outcome Measures:
- The primary endpoints are the degree of hepatic impairment, steady state nevirapine clearance, and the increase in estimated clearance when trough is supplemented by plasma levels measured one, two and four hours after nevirapine administration
Secondary Outcome Measures:
- Plasma levels of nevirapine metabolites of all patients and Child-Pugh scores among patients with cirrhosis.
|Study Start Date:
|May 2004
|Primary Completion Date:
|June 2006 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Male or female subjects >=18 years of age with HIV-1 infection and chronic liver disease as reflected by a documented biopsy with hepatic fibrosis present.
a. Participants must be receiving nevirapine 200 mg twice daily as part of a stable ARV regimen for a minimum of 6 weeks prior to trough level sample collection.
b. Participants receiving nevirapine 400 mg once daily as part of a stable ARV regimen for a minimum of 6 weeks, who are willing to switch to nevirapi0 mg twice daily for a minimum of 14 days prior to trough collection.
- Participants must have uoxylin and Eosin (H and E) stained slide and one trichrome stained pathology slide available at the time of enrollment. There is no time restriction on liver biopsy slides that pathologically confirm the presence of cirrhosis. The presence of cirrhosis must be documented on the liver biopsy report.
- Current (within the past 4 weeks) HIV antiviral therapy with other NNRTI's.
Concurrent use (within the past 7 days) of any of the following:
- Systemic azole antifungal agents (fluconazole, itraconazole, ketoconazole, etc.)
- Clarithromycin
- Rifampin
- St John's Wort
- Inability to provide a blood sample.
- Patients who have evidence for hepatic or other encephalopathy above Grade 1
- Patients with renal failure who require dialysis.
- Pregnant and/or breast feeding women..
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00144248
Please refer to this study by its ClinicalTrials.gov identifier: NCT00144248
|United States, California
|Boehringer Ingelheim Investigational Site
|Bakersfield, California, United States
|Boehringer Ingelheim Investigational Site
|San Francisco, California, United States
|California Pacific Medical Center
|San Francisco, California, United States
|United States, New York
|Albany Medical College, MC 142
|Albany, New York, United States
|United States, Rhode Island
|Boehringer Ingelheim Investigational Site
|Providence, Rhode Island, United States
|Hopital de l'Hotel Dieu
|Lyon cedex 02, France
|Hopital Pitie Salpetriere
|Paris, France
|Hospital Clinico y Provincial de Barcelona - HIV
|Barcelona, Spain
Sponsors and Collaborators
Boehringer Ingelheim
|Study Chair:
|Boehringer Ingelheim Study Coordinator
|Boehringer Ingelheim
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00144248 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 2, 2005
|Last Updated:
|November 4, 2013
Additional relevant MeSH terms:
HIV Infections
Hepatic Insufficiency
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Liver Diseases
Digestive System Diseases
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
Cytochrome P-450 CYP3A Inducers
Cytochrome P-450 Enzyme Inducers
ClinicalTrials.gov processed this record on September 21, 2017