text:
ONE of a gang of thieves who raided a family's home while they were at a wedding and took a £3,000 haul, has been locked up for 17 months.
Mohammed Razaq was on a suspended jail term for house burglary with intent to steal at the time.
His three accomplices Adam Khan, Mohammed Ziyadd and Ismael Khan, all aged 20, had never been in trouble before and kept their freedom.
Burnley Crown Court had been told how the defendants stole six gold bracelets, worth between £2,500 and £3,000, and £400 cash from the targeted premises in Elm Street, last October 12.
Police found them nearby on a canal bank 20 minutes later. One of them was in possession of a pair of socks while another had decorating masks. The defendants made no comment when questioned.
Razaq, of Colne Road, Adam Khan, of Castle Street, Ismael Khan, of Peart Street and Ziyadd, of March Street, all Burnley, had earlier admitted burglary. Khan, Khan and Ziyadd each received eight months in prison, suspended for 18 months, with 150 hours unpaid work.
Stephen Parker, prosecuting, said the victims and their two children had gone to a wedding in Bradford just before lunchtime.
An hour later, a neighbour saw four men come out of the back of the house. He shouted to them and the four ran off. He phoned police, gave a description of the men and the direction they had made off in. Police found them on the canal bank. None of the jewellery or money was recovered.
Mr Parker said when questioned, no admissions were made by any of the accused and for the most part they made no comment. The canal bank was searched and the only items found, in some undergrowth, were a set of keys taken from the property.
The hearing was told Razaq, who has nine offences on his record, received 12 months in custody, suspended for 18 months last year, after being found hiding in the cupboard at a house he was burgling.
Sentencing, Recorder John Bromley-Davenport, QC, said the victims had returned to find their property defiled. He told the defendants: "It was a mean and very unpleasant offence."


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Societal Dynamics and Fragility: Engaging Societies in Responding to Fragile Situationsby Kanishka Balasuriya Michelle Rebosio Ghazia Aslam Alys Willman Alexandre Marc
Today's world is changing at breakneck speed, shaking the very foundations of many societies. Increased mobility through massive urbanization and migration allows people unprecedented access to different cultures and ideas; advanced technologies speed the pace of human interaction; the globalization of communication offers new forms of social relationships that may directly contradict traditional norms for behavior. These changes create tremendous stresses on relationships in societies - affecting the way youth interact with their elders, the way women and men relate to each other, how urban migrants and refugees relate to their new environments, and so on. The impacts of these changes are felt acutely in 'fragile' situations, where groups and institutions struggle to adapt to the stresses of rapid social change. In the worst cases, where fragility has given way to open violence - people are more than twice as likely to be malnourished, more than three times as likely to be unable to send their children to school, twice as likely to see their children die before age five, and more than twice as likely to lack clean water. In addition to these domestic challenges, the costs of fragility often spill over to neighboring regions in the form of trafficking in illegal goods and persons, corruption, and violence. 'Societal Dynamics and Fragility' frames a fresh approach to these challenges, by focusing on improving relationships across groups and institutions in society. Drawing on case studies from Yemen, Central African Republic, Haiti, Liberia and Aceh (Indonesia), the book provides a framework for understanding and healing the social divides that often get in the way of building capable institutions and exiting from fragility.
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text: Videos uploaded to youtube without permission. Just let me know if anything is wrong and I will attempt to remedy the issue. To Blake specifically, let me know if you want things changed or if you want the videos taken down. I believe you have the ability to send me an email, so do that for the quickest response.


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Happy Customers for our Deep Cleaning Packages services
Powai 29-Sep-15
Nilesh was very patient and dedicated to his tasks, so was vijay a yes mam master !!!!! had Nilesh been a quick thinker the job would hv got done much much faster and in half the time.it took way to long to pill the fridge out which he did in a jiffy with other Helper besides vijay. thank you task bob
Powai 18-Sep-16
The team of two who did the tasks were fantastic gentlemen. They were slightly unwell but performed the cleaning jobs really well. I recommend Taskbob to every working woman who does not have the bandwidth to deal with through cleaning of certain areas of the house. Really excellent services.
Powai 24-Oct-16
Just one word ... Fabulous Service.. i had opted for window cleaning... Mr Santosh Naik and his colleague cleaned every nook and corner of windows... Making it look as good as new... Special Thanks to Taskbob team as well for arranging cleaning team despite of shortage in Diwali time...
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Guys did an excellent job cleaning my 2 upholstery chairs for 300 Rs. They arrived on time . Also were very honest and advised appropriately to not do cleaning for other 2 chaise chairs as they are made of similar but not upholstered washable material. I will use them regularly.
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Week of Kitchen Renovations: Storage and Organization
Our kitchen is small. Not as small as some, but definitely small. We have spent some time thinking about storage and organization such that we can maximize the square footage that we do have. Here are a couple things we've done to help utilize our space in the best way possible.
One thing that I like to do is use plastic or wicker baskets to store similar things together. In this cabinet above the sink, we have a basket of salad fixins and other random things like our kitchen torch, one with various packages of food (salmon, popcorn, jello), and one with cupcake liners. Yes, I can fill a whole basket with just cupcake liners. The fourth basket is just a collection of random bags of stuff that have been opened. This helps to keep things organized and allows you to use the full height of a shelf.
Another thing we use are these cabinet shelves. I got them at Container Store and they provide a great solution for stacking our plates and bowls. The other one is used to hold the cutting boards suspended over the strainer. The strainer also holds all of my measuring cups and spoons.
While I have a reusable lunch bag, Hubby takes his every day in a plastic grocery bag. Although with our reusable grocery bags, we're hoping that we won't have many plastic bags in the house soon enough. Inevitably, we are on the way home from work and stop at the store and have no reusable bags in the car, so we bring a few home every once and a while. This bag holder fits perfectly on the inside of the cabinet door so it's convenient and keeps the pile of bags under control.
We really wanted to keep as much off the counters as possible. An easy organizational tool is the paper towel holder. This one is a one-handed version. So you can pull off a paper towel and tear it with just one hand.
One of the only things that is allowed on the counter is this fun red colander. It's from TJMaxx. It holds produce that is kept at room temperature as well as some random things like post it notes and a pen.
One of the last things we added was the pot rack. I love that it helped to empty the majority of our big cabinet next to the stove. Since we have really tall ceilings, it is pretty high up. Hubby and I can both reach the pots hanging there, but someone much shorter than 5'8″ might have an issue. Hubby installed it centered over the windows in the kitchen.
A couple other smalls things we added include the tilt out drawer for a sponge by the sink. It's just nice to have a place for the sponge.
We also grabbed a couple of these stainless steel over the door hooks. They're great for holding a hand towel or an oven mit with a hook on it. We have one on this cabinet and one on the cabinet by the sink.
Last, I wanted to show my baking cabinet. A lot of people ask about this, so I figured I'd show it. Even though we only have two full sized cabinets on top, Hubby agreed to let me have one of the full sized cabinets to myself. As you can see I have a lot crammed into my cabinet. I like to keep that bottom shelf clean because it's the one I use most. As for the pink plastic baskets – one holds decorating items (piping bags/tips, food coloring etc), and the other holds cookie mix-ins (nuts and a variety of chocolate chips).
If anyone else has any kitchen organization tips, I would love to hear them!
Check out my Week of Kitchen Renovations here.
18 Responses to "Week of Kitchen Renovations: Storage and Organization"
Love those cabinet shelves! They look like a great space saver. I'll have to look into those.
You have so many great solutions!! I'm RUNNING to Bed Bath and Beyond for the plastic bag holder–ours are just free under the sink!!
Anne – it really is great and not to $$ either!
I'm pretty sure you've talked about them before but can you please tell us where you got those neat spice bottles for your sugars? I LOVE them!!!
Shadow – They are part of Pottery Barn's Daily System. The post coming tomorrow will actually go through how we made the shelf and include a link to the spice jars themselves.
the spice jars are so cool!! Can't wait to see more about them 🙂 I love how vibrant all the colors are!
Great organizing! I'm always trying to figure out how I'm going to fit all my stuff in my kitchen. Thanks for the tips! BTW love those spice jars…so cute!
I'll add my admiration of the spice jars as well – what a great way to keep them dry and organized while adding color to your kitchen!
Thanks for the info about the spice jars! They're actually $10 off right now too, so you get 15 jars for $19!!!
…I might have bought two sets… 🙂
Can't wait to see how you guys set up your shelf.
Great ideas! I also love the plastic bag holder among other items. Looking forward to the post on the spice containers.
Hopefully Hubby doesn't hear the price went down so much. He about had a heart attack when I told him I was spending $120 on spice jars!
How is the towel made so it can hung by a loop?
I love love loooove what you've done with your kitchen. It's so functional and looks fantastic. I'm definitely stealing some of your ideas and incorporating them into my kitchen. Thanks!
Use tiered cosmetic cases!
They're absolutely great. You can compartmentalize your things easily everything stays together. =)
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FRANKFORT, Ky. - Remember to boat safely as temperatures climb and traffic on Kentucky's waterways increases around the July 4 holiday season.
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If you want Excel to treat certain types of numbers as text, you can use the text format instead of a number format. For example, If you are using credit card numbers, or other number codes that contain 16 digits or more, you must use a text format. That's because Excel has a maximum of 15 digits of precision and will round any numbers that follow the 15th digit down to zero, which probably isn't what you want to happen.
It's easy to tell at a glance if a number is formatted as text, because it will be left-aligned instead of right-aligned in the cell.
Select the cell or range of cells that contains the numbers that you want to format as text.
How to select a cell or a range
To select
Do this
A single cell
Click the cell, or press the arrow keys to move to the cell.
A range of cells
Click the first cell in the range, and then drag to the last cell, or hold down SHIFT while you press the arrow keys to extend the selection.
You can also select the first cell in the range, and then press F8 to extend the selection by using the arrow keys. To stop extending the selection, press F8 again.
A large range of cells
Click the first cell in the range, and then hold down SHIFT while you click the last cell in the range. You can scroll to make the last cell visible.
All cells on a worksheet
Click the Select All button.
To select the entire worksheet, you can also press CTRL+A.
Note: If the worksheet contains data, CTRL+A selects the current region. Pressing CTRL+A a second time selects the entire worksheet.
Nonadjacent cells or cell ranges
Select the first cell or range of cells, and then hold down CTRL while you select the other cells or ranges.
You can also select the first cell or range of cells, and then press SHIFT+F8 to add another nonadjacent cell or range to the selection. To stop adding cells or ranges to the selection, press SHIFT+F8 again.
Note: You cannot cancel the selection of a cell or range of cells in a nonadjacent selection without canceling the entire selection.
An entire row or column
Click the row or column heading.
1. Row heading
2. Column heading
You can also select cells in a row or column by selecting the first cell and then pressing CTRL+SHIFT+ARROW key (RIGHT ARROW or LEFT ARROW for rows, UP ARROW or DOWN ARROW for columns).
Note: If the row or column contains data, CTRL+SHIFT+ARROW key selects the row or column to the last used cell. Pressing CTRL+SHIFT+ARROW key a second time selects the entire row or column.
Adjacent rows or columns
Drag across the row or column headings. Or select the first row or column; then hold down SHIFT while you select the last row or column.
Nonadjacent rows or columns
Click the column or row heading of the first row or column in your selection; then hold down CTRL while you click the column or row headings of other rows or columns that you want to add to the selection.
The first or last cell in a row or column
Select a cell in the row or column, and then press CTRL+ARROW key (RIGHT ARROW or LEFT ARROW for rows, UP ARROW or DOWN ARROW for columns).
The first or last cell on a worksheet or in a Microsoft Office Excel table
Press CTRL+HOME to select the first cell on the worksheet or in an Excel list.
Press CTRL+END to select the last cell on the worksheet or in an Excel list that contains data or formatting.
Cells to the last used cell on the worksheet (lower-right corner)
Select the first cell, and then press CTRL+SHIFT+END to extend the selection of cells to the last used cell on the worksheet (lower-right corner).
Cells to the beginning of the worksheet
Select the first cell, and then press CTRL+SHIFT+HOME to extend the selection of cells to the beginning of the worksheet.
More or fewer cells than the active selection
Hold down SHIFT while you click the last cell that you want to include in the new selection. The rectangular range between the active cell and the cell that you click becomes the new selection.
Tip: To cancel a selection of cells, click any cell on the worksheet.
Tip: You can also select empty cells, and then enter numbers after you format the cells as text. Those numbers will be formatted as text.
On the Home tab, in the Number group, click the arrow next to the Number Format box, and then click Text.
Note: If you don't see the Text option, use the scroll bar to scroll to the end of the list.
To use decimal places in numbers that are stored as text, you may need to include the decimal points when you type the numbers.
When you enter a number that begins with a zero—for example, a product code—Excel will delete the zero by default. If this is not what you want, you can create a custom number format that forces Excel to retain the leading zero. For example, if you're typing or pasting ten-digit product codes in a worksheet, Excel will change numbers like 0784367998 to 784367998. In this case, you could create a custom number format consisting of the code 0000000000, which forces Excel to display all ten digits of the product code, including the leading zero. For more information about this issue, see Create or delete a custom number format and Keep leading zeros in number codes.
Occasionally, numbers might be formatted and stored in cells as text, which later can cause problems with calculations or produce confusing sort orders. This sometimes happens when you import or copy numbers from a database or other data source. In this scenario, you must convert the numbers stored as text back to numbers. For more information, see Convert numbers stored as text to numbers.
You can also use the TEXT function to convert a number to text in a specific number format. For examples of this technique, see Keep leading zeros in number codes. For information about using the TEXT function, see TEXT function.


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Category: frilly names
Romantic names for girls – loosely defined as creative and elaborate names that suggest an earlier era and a Latinate emotionality – have become more fashionable in recent years. As we grow more comfortable with the notion of equality for girls, we may also become confident enough to give our daughters elaborately feminine names rather than having to make our point with androgynous, modern monikers like Blair or Blake.
Of course, not every romantic name is a feminist statement. These names may just feel fresh again after decades of sleeker, more straightforward girls' names like Mary and Betty, Karen and Lisa. Even Jennifer and Ashley pale in the face of these flagrantly feminine names.
The rise of Isabella and Sophia to the Top 10 means that Romantic Names are now mainstream. Some choices further off the beaten track:


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Keep the brain sharp as you age with phosphatidylserine ("PS" for short) supplements. PS is a natural phospholipid compound that the body can make on its own. However, age or deficiencies in B vitamins or essential fatty acids can prevent the body from producing enough PS. PS has been shown to promote memory and cognitive function as well as support mood health. It does this through its role in neurotransmitter function and by maintaining structural integrity of brain cell membranes. Most PS supplements are made from vegetarian sources, namely soy lecithin. Swanson Ultra Phosphatidylserine features three soy-based formulas plus a soy-free formula made from sunflowers.
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My marathon is this Sunday, May 5th. Forecast is sunny with a high of 70 degrees, little to no wind. Race starts at 7:30 am and the final 10k is along a lakefront. I'm just a bit concerned that it will be a warm day and if that would adversely affect my performance?
Is 70 Degrees as a High a Concern?
The day's high, while somewhat telling, isn't really relevant. The high isn't usually reached until mid-afternoon. Look at the hourly forecast. I don't know your pace, but with a 7:30am start, you're probably finishing sometime around noon or earlier. Depending on how quickly it heats up, you may not see temps higher than mid 60s. Still less than ideal in my book, but not catastrophic. At those temps, I would be more concerned about high humidity.
What race?
Lakes tend to be pretty cold in early May and bigger ones can influence the temperatures nearby so that is also in your favor.
I agree, look more at the hourly forecasts and don't be too concerned about the afternoon high.
BillO - it the Mississauga Marathon which is located just west of Toronto, Ontario. I think you're right about the lake being a plus - it's Lake Ontario so HUGE.
A fellow southwestern Ontarian here! I think the weather will be almost perfect at 7:30 a.m if the high is 21ish. A little warm by the finish maybe, but it probably won't be your main focus by then. ; )
edan - are you running Mississauga?
dkgg - well that sounds much more promising than what I've been looking at! I hope you're right LOL!!
Dew point would be more of a concern to me. Mid-60's is getting to where I would be affected by the temp - if the humidity were also up that'd be a big factor.
I agree with NC Ken, Dew points will tell you more.
It's going to be a great day for a half. The more important factor will be dressing right for the race. There's going to be hundreds of people there wearing their running room jackets! Don't be one of them. You can wear an old sweatshirt to the start or the classic garbage bag look to stay warm. But once the race starts strip down and if you're a bit cold at the start that's perfect!
This is a strange thread to be reading from Florida. When I saw the title, I thought, "Heck yes, a high of only 70' would be a concern. That would mean it could be in the 50s (or lower) when I run in the morning - too cold!"
This is a strange thread to be reading from Florida. When I saw the title, I thought, "Heck yes, a high of only 70' would be a concern. That would mean it could be in the 50s (or lower) when I run in the morning - too cold!"


text: Firestone Racing Welcomed By EPA As National Partner For Environmental Priorities At Chicago Auto Show February 16, 2009 12:00 AM On behalf of the Firestone Racing Program, Al Speyer, Executive Director of Firestone Racing and Greer Tidwell, Director of Environmental Management will accept recognition as a partner in the Environmental Protection Agency's National Partnership for Environmental Priorities (NPEP). The NPEP highlights environmental leadership through voluntary reduction of priority and hazardous chemicals such as lead. During 2008, Firestone Racing permanently replaced the use of all lead wheel weights with non-toxic composite wheel weights and became a charter member of the National Lead Free Wheel Weight Initiative. Although the number of race cars may be small compared to the thousands of vehicles serviced at Firestone Complete Auto Care™, Tires Plus™, ExpertTire™ or Wheel Works™ service centers, which also chose to voluntarily install non-toxic steel wheel weights, proving the switch can be done on the racetrack is an important highlight of the Lead-Free Wheel Weight Initiative. WHO: Janet Haff, Environmental Protection Agency Al Speyer, Executive Director, Firestone Racing Greer Tidwell, Director Environmental Management, Bridgestone Americas Tire Operations WHAT: Plaque presentation and photo opportunity WHEN: Wednesday, February 18, 2009 2:00 p.m. WHERE: Bridgestone Americas, Inc. Exhibit (Booth NH3) Chicago Auto Show, McCormick Center, Chicago, Illinois Back to News


text:
Roenicke would like more looks at Davis
GLENDALE, Ariz. -- Brewers spring phenom Khris Davis continued to soak up the Cactus League action Sunday, making a start as the designated hitter and taking advantage of left fielder Ryan Braun's absence from the lineup as he recoves from his participation in the World Baseball Classic.
"It's a breath of fresh air," Davis said of the attention he's commanding this spring. "I have to appreciate it while it lasts."
The 25-year-old, ranked as the Brewers' No. 16 prospect by MLB.com, has forced himself into the roster conversation, and manager Ron Roenicke wants to see as much as possible of Davis before Braun returns to the lineup midweek.
"When Brauny gets back in there, it's going to limit [Davis'] playing time, but I'd like to maybe give him some pinch-hit at-bats in some of these games and see how he looks there," Roenicke said. "If it worked out to where he was on the club, that's the role he'd be in, not starting, probably."
Davis was slated to start the season at Triple-A, where he played 32 games last season after starting the season at Double-A, and the organization would typically want to ensure regular playing time for him, but it could be tough to resist a right-handed bat with power off the bench.
"Bench player is a tough role, but it doesn't scare me," Davis said. "I've done it before. I did it in college. I didn't start my sophomore year, and I came off the bench for some pinch-hits and had good success. So I've got confidence in that area."
Owen Perkins is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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The Greater Chiefland Area Chamber of Commerce will close nominations for 2013 Citizen of the Year Wednesday, Feb. 5. The honoree will be presented with an award at the Chamber's annual banquet Feb. 25.
Nominations can be mailed to the Chiefland Chamber at P.O. Box 1397, Chiefland, Fl, 32644, emailed to firstname.lastname@example.com, faxed to 352-493-0282 or dropped off at the Chamber office, located at 23 S.E. 2nd Ave., in Chiefland. The office hours are from 10 a.m. to 2 p.m. Monday through Friday.
For more information, call the Chamber at 352-493-1849.
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text:
Validation of Two New Questionnaires for Dupuytren's Disease
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2015 by Robert Hotchkiss, Hospital for Special Surgery, New York.
Recruitment status was: Active, not recruiting
Recruitment status was: Active, not recruiting
Robert Hotchkiss
Auxilium Pharmaceuticals, Inc.
Information provided by (Responsible Party):
Robert Hotchkiss, Hospital for Special Surgery, New York
ClinicalTrials.gov Identifier:
First received: October 3, 2011
Last updated: April 1, 2015
Last verified: April 2015
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
A study to validate two newly developed questionnaires for Dupuytren's Disease. The objective is to develop a patient specific outcomes tool for Dupuytren's Disease. While there are standard and validated questionnaire instruments used to measure health related quality of life and function, they do not address patient specific issues. The investigators will also pilot a treatment/disease specific satisfaction questionnaire for Xiaflex use for Dupuytren's Disease.
|Dupuytren's Disease
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|A Prospective Study to Validate Two New Patient Reported Outcome Measures for Dupuytren's Disease in Patients Treated With XIAFLEX
Resource links provided by NLM:
Genetics Home Reference related topics: Dupuytren contractureU.S. FDA Resources
Further study details as provided by Robert Hotchkiss, Hospital for Special Surgery, New York:
Primary Outcome Measures:
- QuickDASH (Disability of the Arm, Shoulder, and Hand) [ Time Frame: 30 day follow up ]
|Estimated Enrollment:
|Study Start Date:
|February 2011
|Estimated Study Completion Date:
|December 2015
|Estimated Primary Completion Date:
|December 2015 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|35 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
Patients receiving treatment with XIAFLEX for Dupuytren's Disease
Inclusion Criteria:
- Subject has a diagnosis of Dupuytren's Disease in at least one finger
- Patients will be 35 years of age or older
- Patients will be able to read, speak, and understand English
- Patients will be able to provide voluntary written consent to participate
Exclusion Criteria:
- Female patients who are nursing or pregnant, or plan to become pregnant during the treatment phase.
- Patient has a chronic muscular, neurological or neuromuscular disorder that affects the hands.
- Patient has a known allergy to collagenase or any other excipient of XIAFLEX.
- Patient has received any collagenase treatments before the first dose of XIAFLEX.
- Any history of or current medical condition which in the investigator's opinion would make the subject unsuitable for enrollment in the study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01446432
Please refer to this study by its ClinicalTrials.gov identifier: NCT01446432
|United States, New York
|Hospital For Special Surgery
|New York, New York, United States, 10021
Sponsors and Collaborators
Robert Hotchkiss
Auxilium Pharmaceuticals, Inc.
|Principal Investigator:
|Robert N Hotchkiss, MD
|Hosptial for Special Surgery
More Information
Keywords provided by Robert Hotchkiss, Hospital for Special Surgery, New York:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Robert Hotchkiss, MD, Hospital for Special Surgery, New York
|ClinicalTrials.gov Identifier:
|NCT01446432 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 3, 2011
|Last Updated:
|April 1, 2015
Keywords provided by Robert Hotchkiss, Hospital for Special Surgery, New York:
Dupuytren's Contracture
Additional relevant MeSH terms:
Dupuytren Contracture
Muscular Diseases
Musculoskeletal Diseases
Connective Tissue Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating Cholangiocarcinoma
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|Drug: CT scan
|Early Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Intervention Model Description:
Single arm study, with dose adjustment.Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|The Role of Gadoxetate Enhanced Spectral Dual-Energy CT in Evaluating Hilar Cholangiocarcinoma
- Number of Subjects Where Hilar Cholangiocarcinomas Could be Visualized Using Gadoxetate Disodium Enhanced Dual Energy CT [ Time Frame: 24 hrs ]CT scans were assessed for tumor visualization after use of Gadoxetate disodium
|Study Start Date:
|August 2012
|Study Completion Date:
|January 2014
|Primary Completion Date:
|January 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: CT imaging
Patients will undergo a standard of care Gadoxetate (Eovist) MRI for cholangiocarcinoma. Patients will then be immediately placed on the CT scanner. Patients will undergo a dual energy CT of the abdomen with no additional contrast.
Drug: CT scan
Gadoxetate (Eovist) enhanced dual energy CT
Other Name: Dual Energy CT
Detailed Description:
The purpose of this project is to evaluate the role of gadoxetate (Eovist) enhanced dual-energy CT in better evaluating perihilar cholangiocarcinoma, by exploiting the combination of the physiologic behavior of gadoxetate in liver tissue combined with the advantageous mass attenuation coefficient of Gadolinium achievable through dual energy technique. This combination of unique CT imaging sensitivity, high resolution and differential enhancement potentially allows improved visualization and detection of tumor relative to enhancing surrounding hepatic parenchyma and ductal anatomy in the hepatobiliary phase, due to the biliary excretion of the agent.
Cholangiocarcinoma is a hepatic adenocarcinoma that arises from the bile duct epithelium and is the second most prevalent liver cancer after hepatocellular carcinoma. The hilar intrahepatic variety of cholangiocarcinoma can present as an infiltrative, exophytic, or polypoid lesion. Most extra-hepatic cholangiocarcinomas are infiltrative, causing a focal stricture of the bile duct and result in proximal biliary ductal dilatation.
While magnetic resonance (MR) cholangiography is diagnostic in the majority of patients with malignant hilar strictures, evaluation is limited by spatial resolution and in some patients, the inability to have an MRI scan. Standard Multi Detector CT (MDCT) using iodinated contrast agents, on the other hand, is limited in evaluation of cholangiocarcinomas, due to the lack of consistent enhancement of the tumor with iodinated contrast.
Single-source, Dual-Energy (SSDE) Spectral MDCT utilizes a single fast switching x-ray beam source to acquire near simultaneous data sets at two different photon energies during a single acquisition. Data is acquired at 80 kilovolt peak (kVp) and 140 kVp with image reconstruction achievable as a selectable monochromatic presentation over a range of 40 - 140 kiloelectron volt (keV), typically 70-78 keV for diagnostic image presentation. At lower tube voltage, the frequency of photoelectric interactions increases exponentially and is strongly dependent on the atomic number. Therefore, for substances with higher atomic number, such as iodine and gadolinium the increased frequency of photoelectric and k-edge interactions at low tube voltage substantially increases CT attenuation, thus improving contrast. Gadolinium is further unique with k-edge attenuation at approximately 53 keV, within the available monochromatic reconstruction range, thus allowing for significant greater detectability. Additional material decomposition technique allows for unique material presentation and analysis such as gadolinium/ water pair analysis with high spatial resolution.
Dual-Energy technology is limited by the types of contrast agents currently available, all based on Iodine. Gadoxetate (Eovist) is a relatively new Gadolinium based MRI contrast agent that is capable of producing not only standard appearing MRI images in the hepatic arterial and portal venous phases, but also provides an opportunity to better visualize the bile ducts and liver parenchyma as it is excreted by the liver into the biliary system during the hepatobiliary phase.
This pilot project aims to address a long-term pitfall in the imaging of cholangiocarcinomas, by providing higher resolution delineation of these often infiltrative tumors on single-source, Dual-Energy Spectral MDCT, capitalizing on improved spatial resolution achievable with MDCT compared to MRI and at the same time producing a non-invasive CT cholangiogram to aid in accurate diagnosis and treatment planning of cholangiocarcinoma, particularly, the hilar variety.
|Ages Eligible for Study:
|19 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Subjects will be adult (age 19 or older) with suspected cholangiocarcinoma of the liver.
- Subject must be able to provide a written informed consent.
- Subject will be scheduled for gadoxetate contrast enhanced MRI scan of the liver (obtained as part of usual clinical practice).
Exclusion Criteria:
- Standard MRI safety screening criteria will be employed, and subject will be excluded if any contraindications to undergo MRI are met.
- Subjects with metallic biliary stents or multiple peripancreatic surgical clips on abdominal MDCT will be excluded.
- Subjects on hemodialysis or with glomerular filtration rate (GFR) less than 30 will be excluded.
- Subjects will not be excluded on the basis of gender, race, ethnicity, or religion.
- Subject may not be pregnant or lactating.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01673802
|United States, Alabama
|University of Alabama at Birmingham
|Birmingham, Alabama, United States, 35294
|Principal Investigator:
|John V Thomas, MD
|University of Alabama at Birmingham
|Responsible Party:
|John V. Thomas, Associate Professor, University of Alabama at Birmingham
|ClinicalTrials.gov Identifier:
|NCT01673802 History of Changes
|Other Study ID Numbers:
117354 ( Other Identifier: FDA )
|Study First Received:
|August 13, 2012
|Results First Received:
|May 20, 2014
|Last Updated:
|April 12, 2017
Keywords provided by John V. Thomas, University of Alabama at Birmingham:
Additional relevant MeSH terms:
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
ClinicalTrials.gov processed this record on September 21, 2017


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On September 14th, 2017, we published revised versions of our Privacy Policy, Terms of Service and Website Use Policy and published a Cookie Policy. Your continued use of Lynda.com means you agree to these revised documents, so please take a few minutes to read and understand them.
By Sean Adams | Tuesday, October 6, 2015
A new artisan butcher shop opened in my neighborhood last week. Further down the block is a bespoke one-of-a-kind gift shop. Clearly, there's a return to the handmade and authentic over mass-produced goods.
As I show in my new Lynda.com course on the Foundations of Graphic Design, the Arts and Crafts movement grew out of the same sensibilities: the rejection of cheap machine-made products and elevation of craft and design with the handmade, unique materials and pride of workmanship.
Charles Sumner Greene and Henry Mather Greene were two of the most influential adopters of the Arts and Crafts style in the early 20th century.
I'll show you how their iconic Greene and Greene California bungalows represent the apex of the nation's Arts and Crafts movement.
By Julian Velard | Saturday, October 3, 2015
I wrote my first song when I was 15 years old. It was an ode to Pee Wee Herman called, "Pee Wee, Why Can't You See Me?"
Sadly there's no recorded evidence of my nascent masterpiece, but I remember it being in traditional verse/chorus form with an eight-bar bridge.
As a sophomore in high school, I knew nothing about song form, let alone bars or beats. It was just what sounded right to me. I spent the majority of my teenage years immersed in the music of the '60s and '70s; while everyone else was wearing plaid and listening to Pearl Jam, my Discman had Elton John's Tumbleweed Connection and Stevie Wonder's Songs in the Key of Life on repeat.
By Starshine Roshell | Thursday, October 1, 2015
Leadership coach Fred Kofman has a way of making profound, game-changing concepts sound so simple that you wonder why you didn't think of them yourself.
"I'm just reminding people of what they already know," says Kofman, who's worked with execs from Google to Microsoft to GM. "That's why they feel at home with the ideas—like with an old friend."
Author of the book Conscious Business and vice president of LinkedIn, he shares his world-class listening, negotiation and relationship-building tips in the new Lynda.com course Fred Kofman on Managing Conflict.
With a PhD in economics from UC Berkeley and a Teacher of the Year award from MIT, Kofman helps organizations incorporate honesty, integrity and respect into their business decisions and corporate cultures.
Here he tells us about the two biggest mistakes he sees businesspeople make—and the time he struggled to follow his own advice …
By Jeff Carlson | Tuesday, September 29, 2015
How many times have you heard someone say they need Photoshop to edit photos? Perhaps because it was first, or because talented artists have done amazing things with it over the years, Adobe Photoshop has become synonymous in many people's minds with manipulating digital photos.
And yet, Photoshop is one of the biggest iceberg applications out there: Most people, even many experts, use only a small percentage of what Photoshop CC 2015 (the latest version) is capable of.
That's why Adobe also sells Photoshop Elements, which has just been updated to version 14. Originally designed as a "Photoshop Lite," Elements is now nearly as capable as its older sibling, especially for most general-purpose photo editing.
By Lauren Nilsson | Tuesday, September 29, 2015
Islamic artwork is often based on complex geometry: shapes and lines that align precisely.
While it's not strictly representative, this geometry invokes stars, plants, planets, and other elements of the natural world. It's breathtaking to behold in person at sites like the Alhambra, a Moorish palace—and the imagery inspires designers around the world.
A Tunisian stained glass window inspired the Islamic design featured in this week's free episode of Deke's Techniques.
Deke uses a picture of the window as a template in Illustrator, but if you follow along with his instructions, you can re-create the pattern on your own, from scratch.
By Fred Kofman | Tuesday, September 29, 2015
It is precisely when listening is most important … that you want to listen the least.
In my brand new Lynda.com course Managing Conflict, I show you how to approach personal and professional conflicts in a way that helps both sides find a satisfying resolution.
But the first step toward resolving any conflict is listening.
By Larry Crane | Friday, September 25, 2015
From starting my first band 30 years ago to running a professional studio since 1997, I've spent a lot of days in recording studios. And I've learned that artists in the studio need a lot of support.
A great engineer or producer is always anticipating clients' needs and helping to keep them productive. Sometimes you even need to think like a detective or archaeologist to find answers to difficult problems.
That's what I did for one rock group that "lost" an important drum track for the album they'd recorded. With the recording tricks I share in my video series Music Production Secrets, I was able to help them—and produce a great, usable mix.
It just took a little studio magic …
By Robbie Carman | Friday, September 25, 2015
Monitors, monitors, monitors. They help you catch things you might not ordinarily see with the naked eye.
There are a multitude of monitors out there ranging from small field monitors to 4K monitors to computer displays. Which one is right for you?
This week on Video Gear Weekly, Rich and I show you a few of the latest possibilities to help you figure out which monitor could benefit your workflow.
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text: |The information we provide is for a guide only, please always consult a financial advice group. This is a list of Financial Advisors in 9x5Ss13f. You will also be able to find Loans in 9x5Ss13f and 9x5Ss13f loans as well as 9x5Ss13f Financial Consultants 9x5Ss13f. Most of the firms listed below can offer Secured Loans in 9x5Ss13f, Unsecured Loans in 9x5Ss13f, Cash Loans in 9x5Ss13f and even car loans in 9x5Ss13f.


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What is portfolio insurance
Invariably, when the subject of the Crash of 1987 is discussed, something called portfolio insurance is mentioned in association with the decline. To this day few investors are familiar with what it is, and most only have a vague notion that it had something to do with exacerbating the steep fall that occurred in the index averages almost a decade ago. Portfolio insurance was a risk management weapon forged in the raging furnace of market decline, but when tested in battle it quickly revealed a critical flaw.
The concept of portfolio insurance, indeed the name itself, reflects the ardent wishes of its creators for a utopian investment vehicle capable of minimizing the pain of investment loss. The idea was simple, all one would have to do was pay something akin to an insurance premium, and investment downside could be forever limited. Unfortunately, as so often occurs in the realm of human affairs, reality served an unwilling partner.
The inspiration for portfolio insurance oddly enough came from an academic setting. In September 1976, Hayne Leland, a young finance professor at Berkeley, consumed with worry over his familys finances had a midnight brainstorm. He approached a colleague, Mark Rubinstein, the following morning and the pair became so enamored of their ideas that they decided to form a company to market their new product called portfolio insurance. However, it wasnt until a full two years later that the duo had ironed out all the kinks in their trading strategy, and with the help of professional marketer and portfolio theorist John OBrien they scored their first client in 1980.
From inauspicious beginnings came a virtual tidal wave of demand for the groups product, as well as a whole host of competitors offering similar investment insurance. In fact, by 1987 approximately $60 billion in equity assets were covered by different varieties of portfolio insurance, the majority of which was on behalf of conservative pension funds.
The initial concept underlying Lelands creation was to replicate the performance of a put option in what was referred to as a dynamically programmed system, where a client was automatically shifted out of a position (via computer) when it began to fall, increasing the clients cash as long as the stock fell and insuring that a predetermined amount was all that the client could lose.
Heres how it worked: Say you bought 100 shares of Replicants R Us at $100 a share, and simultaneously bought a put -- the option but not the obligation to sell Replicants stock to someone else at a stated price over a specified period of time -- with an exercise price of $90. In this way, no matter how low Replicants R Us shares dropped due to malfunctioning replicants killing humans, you couldnt lose more than $10 on each share. In this example the floor was set at $90, and by the time the stock reached this price in the market, your portfolio would be 100% in cash. The distance then, between the starting point and the floor, was like a deductible on a normal insurance policy -- the $10 per share being the amount that you as a policyholder would have to cover. So if the market fell, the portfolio would slowly liquidate some positions, but still hold some stock. If the market rose, the portfolio would be buying, but still hold some cash. The slight degree of underperformance, in both directions, that results serves as the premium for the insurance.
Today, in a period when program trading is routine, this particular scheme looks a little archaic. However, at the time, the mechanics of running an operation in which hundreds of simultaneous buy and
sell orders needed to be executed for just one portfolio were understandably complicated as well as costly. In addition, active portfolio managers bristled at being second-guessed by "some computer. The saving grace for human and computer alike came in the form of futures contracts on the S&P 500, made available in 1983. These contracts allowed investors to buy or sell a proxy for the overall market, that is, an index of 500 leading companies in leading industries.
Under the guise of portfolio insurance, the futures transaction in this instance was an agreement to sell the intangible commodity of 500 stocks in the index at a specified date and a prearranged price. Portfolio managers would hedge their stock portfolios by selling index futures. Instead of buying and selling hundreds of stocks and options, the S&P index futures promised an effective, inexpensive, and greatly simplified form of portfolio insurance. They functioned almost exactly like the put scenario described previously, with one crucial difference that left the promise unfulfilled.
The owner of the futures contract makes a cash settlement based upon the variation in the index between the signing of the contract and its maturity. Every day investors are required to fork over cash to the exchange (which represents the other side of the transaction, as opposed to an individual or firm) to keep the contracts fully collateralized. The actual construction of the futures contract was not the problem in 1987, it was the selling of shares in the stock portfolio in order to make the hedge worthwhile.
Recall the put scenario. This option was "put" to the seller at the exercise price of $90. Again, that means however low Replicants R Us shares dropped in the market, the seller of the Replicants put is legally bound to buy the shares at $90 if the owner of the option puts the stock. That was the insurance -- Relicants R Us stock could fall to $30, but the seller was obligated to buy at $90! However, with the stock index future, it could be sold and the money could be collected, but in order to make it all worthwhile the stocks in the portfolio had to be sold to prevent the loss.
The crucial difference boiled down to the fact that the market was not obligated to purchase any of that portfolio stock at the price that the portfolio manager wanted. Those who used index futures as a hedge assumed that the necessary liquidity would be available from the market. It wasn't. The truth is, during the crash most "insured" portfolios did better than those that were "uninsured," but the selling of the portfolio stock took place at prices far lower than anticipated. For example, instead of locking in a price at $90 for Replicants R Us shares, those that insured their portfolios with index futures would have undoubtedly received a price below $90 because the buyers were just not there during the waves of selling that occurred.
On the weekend before the crash, an enormous overhang of sell orders had built up, for in the previous week the Dow Jones Industrial Average had fallen 250 points, or about 10% (with half of the drop on Friday). During all this, managers of "insured" portfolios were selling index futures and dumping their portfolio stock. On Monday all the programmed sales kicked in, the market dropped 100 point by noon, another 200 points in the ensuing two hours, and 300 points in the final hour. As Peter Bernstein notes in Against the Gods: The Remarkable Story of Risk. "The cost of portfolio insurance in that feverish market turned out to be much higher than paper calculations predicted."Source: www.fool.com
Category: Insurance
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I'm officially back from my longest hiatus to date. The family's doing great and I was able to write a few posts and work on some projects that I'd been meaning to get to. Thanks again to the guest bloggers that supplied some great posts from Europe, Australia, the West Coast, Midwest, & East Coast of the U.S. While I was out: Author Aric Davis, Ashley from Theme Park News Direct, Austin from Theme Park Syndicate, Jake from Coasterdom & Nick from Theme Park Tourist did an excellent job keeping the blog afloat. I genuinely enjoyed reading their posts and I'm lucky to have their work to share. You may be seeing a post here or there from these fine writers in the future, but I'm officially back in action full-time.
4 Years of Blogging- New Additions, New Site, New Features & A Notable Removal
Last April The Coaster Critic's Blog turned four! After more than 600 posts, nearly 4,800 comments & over 350,000 visitors from all over the globe, I'm happy to say that the blog is still going strong. In fact, a new feature that's been in the works for a while will be launched later this week. I'm excited to get your feedback. Aside from the new feature, there's also a whole new domain on the horizon. The new site will really just compliment something I'm already doing and it's not another large project like Theme Park Syndicate. Also, it's not entirely theme park related. It'll make more sense when I've officially announced it (probably in the next few weeks).
During my hiatus I did some rehab on the blog. I've updated the roller coaster reviews page by adding sorting to the tables and adding the guests reviews, and I've made a notable removal. More on the removal later this week.
This will be a slow year for coaster trips, but there's a chance that I'll make it back to Kings Dominion. Perhaps fittingly, I'll be returning to my home park where it all started to ride my 200th roller coaster and Intimidator 305. I may also get to check out Family Kingdom thanks to another family trip to Myrtle Beach. Sadly, Freestyle Music Park won't be open, but a ride credit on the fun-looking woodie, Swamp Fox, will lessen the sting.


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Prescription drug abuse takes deadly toll in W.Va.
here. See a related story, "Preventing prescription drug overdoses: Where West Virginia stands," here. For more stories in this series click here. This is the first in a four-part series examining prescription drug abuse in West Virginia.ST. MARYS, W.Va. -- By the time he was in his 20s, Nick Bills had gone through so many medical procedures, he swore he could do brain surgery.When he started abusing prescription drugs, he thought he could handle it.On a July night in 2009, the 26-year-old pulled his pickup into the parking lot of a St. Marys bar. There, he squeezed the clear gel out of a fentanyl patch, mixed it with water, and injected it into his 6'2" frame.He died there that night.In a sense, he didn't die alone. Prescription drug overdoses now kill hundreds of West Virginians every year:
In 2008, the latest year for which data is available, 390 West Virginians died from accidental overdoses involving prescription drugs, according to the state Health Statistics Center. In 2001, 91 West Virginians died this way. West Virginia has the nation's highest rate of drug deaths. Between 2001 and 2008, more than nine out of 10 of those deaths involved prescription drugs. Drug overdoses now kill more West Virginians each year than car accidents do. It's the leading cause of accidental deaths in the state. Between 2001 and 2008, the statewide death rate of overdoses involving prescription drugs more than quadrupled, from 5.1 deaths per 100,000 residents to 21.5.Many people still don't realize how dangerous it is to abuse prescription drugs, said the state's chief medical examiner, Dr. James Kaplan."They need to know that it is like playing Russian roulette," he said.'I didn't expect this'
"This is Nick in a nutshell," said his mother, Vivian, picking up a photo of a family reunion. "Nick and the old men telling stories at the Bills reunion. He was so interested in all their stories."She always worried about her son. He had abused alcohol for years."Every night, I expected a call of some kind, that he was in trouble," she said. "I didn't expect this."A week before he died, Nick told his mother he wanted to go to rehab. She assumed he wanted help for his alcohol problem. She wishes she had taken him right away.His problems had started early. When he was about 9, he found a gas can his brother had for the lawn mower. He found a lighter, too. The fire burned 20 percent of his body."His personality changed with that extreme pain," his mother said.She remembers Nick wrapped in gauze at the hospital. He looked like a little mummy.After the fire, his happy-go-lucky demeanor disappeared. He struggled in school.Doctors ordered Nick to wear pressure garments - tight, uncomfortable things to stop his scar tissue from puffing up. As a child, he peeled them from his limbs and threw them in the weeds on the way to school. His parents never found them.He had nightmares of being burned, his mother later learned. Something else haunted him, too: A deep sense of inadequacy."Stupid, fat and ugly." That's how he thought of himself.She was relieved when he found a career he loved after high school. He became a union ironworker.Around age 20, Nick suffered another accident. One night, as he rode as a passenger with his arm hanging out of the window, the driver whipped past a pole that was close to the roadway. Nick shattered his elbow.His career as an ironworker ended. He could only lift a few pounds, a gallon of milk at the most. He had to sleep in a recliner. He wore special Velcro shirts to accommodate the metal rods inserted into his injured arm.Although in great pain, he didn't need all of the drugs doctors prescribed him, said Logan Bloomer, Nick's ex-girlfriend and the mother of his 3-year-old daughter, Addison. He amassed a collection of pain pills that covered the top of the refrigerator at his sister's house, where he was staying."[Doctors] just kept giving him more when, to begin with, he wasn't taking a lot," Bloomer said, "so it just kind of backed up."Friends wanted the pills. He was happy to share. "It made him feel important," said Bloomer, who was no longer dating Nick when he died. "It made him feel needed." Research shows that nearly two-thirds of West Virginians who misuse pain relievers get them from friends or relatives for free.As time went on, Nick developed a taste for them himself. He didn't want to give them away.'A sense of urgency' Last year, National Drug Control Policy Director Gil Kerlikowske called prescription abuse "our nation's fastest-growing drug problem."Nationwide, deaths from drug overdoses more than doubled between 1999 and 2007, according to the federal Centers for Disease Control and Prevention, with opiate painkillers fueling the increase. These drugs, which include fentanyl and oxycodone, act on the central nervous system.The problem hit West Virginia hard and early, said Dr. Rolly Sullivan, a psychiatry professor and director of addiction services at the West Virginia University School of Medicine.In the 1990s, "I was so completely overwhelmed with patients hooked on prescription drugs that I thought it was just a completely hopeless case," he said.During that period, there was a movement to treat pain more aggressively.OxyContin became available in 1996. The drug was heavily marketed to doctors who were "underprepared to judge the risk of addiction," Sullivan said.Today, he sees all kinds of people struggling with painkiller addictions. His patients include a lawyer and a woman living in a homeless shelter.Experts don't know exactly why the problem is so bad here, but they point to several factors.Prescription drugs are abundant in West Virginia medicine cabinets. Residents of the state filled nearly 19 prescriptions per capita in 2009, the most in the nation, according to the Kaiser Family Foundation. The national average was 12.Many West Virginians work in industries where they get hurt, like coal mining.Help for addiction is hard to find, Sullivan said. "There's been pathetically inadequate treatment options," he said. "The state has been really slow to finance any."Then, there is the lasting misperception that prescription drugs are safer than illegal drugs."There's a huge level of ignorance behind this because [people] don't know about the drugs," said Mike O'Neil, pharmacy professor at the University of Charleston and an expert on drug diversion. People abuse many types of prescription drugs: Painkillers, tranquilizers, stimulants and sedatives.Opiate painkillers cause so many overdose deaths because of the way the body develops tolerance to them, O'Neil said."Over time - and usually fairly quickly - we actually develop tolerance to the sedative effects of these drugs," O'Neil said, "and we develop tolerance to the euphoric or buzz effects."The body, though, doesn't develop tolerance to opiates' respiratory-depression effects -- the way they make the lungs breathe shallower and slower. As an addict takes more opiates to get the same feeling, the drugs can make them stop breathing.Mixing drugs with each other or with alcohol also can be deadly, he said.Injecting, snorting or smoking a drug increases the likelihood of addiction, O'Neil said. The drugs reach the brain faster and at higher concentrations because they bypass the digestive system."It also overloads other organ systems," he said, "like the heart or respiratory systems."Some states have made fighting prescription drug overdoses a top priority. In Utah, for instance, legislators in 2007 passed a law creating a program aimed at reducing deaths by prescription drugs by 15 percent.The state researched overdose deaths to determine which factors made some Utahans more likely to die from prescription drugs. A statewide media campaign educated people on the dangers of prescription drug abuse. Utah also created clinical guidelines for practitioners prescribing opiate pain medications.In 2008, Utah saw a nearly 13 percent decrease in prescription-drug overdose deaths from the previous year.In Ohio, then-Gov. Ted Strickland signed an executive order last year creating a state Prescription Drug Abuse Task Force. In October, the task force released a final report of 20 recommendations related to areas like treatment, law enforcement, and public health.West Virginia House of Delegates Health and Human Resources Chairman Don Perdue said he wants to see the Mountain State take similar steps."Unless we develop a sense of urgency about this problem, we will not do anything that's effective," the Wayne County Democrat said. "It's not penetrating the consciousness of the public in the way that it should."'He wanted to get better'Nick Bills' family doesn't know where he got the fentanyl patch that killed him. At the time, he had a prescription only for Vicodin, Bloomer said.But prescription drugs are easy to find, said Bloomer, who is recovering from painkiller abuse.When she and Nick abused drugs together, they had a friend with cancer who sold his OxyContin pills and fentanyl, a drug 80 times stronger than morphine. They knew people who worked for a company that collected unused drugs from nursing homes and rehabilitation centers. Instead of disposing of them like they were supposed to, they sold them.When Nick's arm healed enough for him to work again, he found a new job as a heavy-equipment operator, running cranes and bulldozers.Bloomer snuck him pills while he was working. At eight months pregnant, she stopped in a gas station daily to buy a piece of pizza. She dug her fingers through the crust, stuffed pills inside and dropped off the pizza at his job site.One day, the two went driving around. By that time, Bloomer said, they couldn't get high any more. They wanted to not feel sick from withdrawal.They looked for "old people's cars" like Cadillacs in the driveways, Bloomer said. They stopped at the houses and pretended to be lost. She asked to use the bathroom and scoured the medicine cabinets."I can remember going home, and we didn't get anything," she said. "We had to crawl back home, and we were so ashamed. And that's when we would look at each other like, 'This is sad, this is serious.'"Bills can't imagine her son doing that."He would do anything for anyone," Bills said. "Any favor was not asking too much. He just was loveable - that other side, I didn't see."Nick did his best to hide his addiction, Bloomer said, especially from his family."He wanted to get better," she said, "but he was too afraid for people to find out that he was sick."He had always been a private person."Drinking brought him out of that shell," Bloomer said, "and so did pills. I think it was his way of being the person that he wanted to be."Last month, Bills spent her second Christmas without Nick."It's almost harder as time passes on," she said.The numbness is wearing off.She thinks of him when she sees birds or stars. He always noticed those things.Some days, when she drives over the mountain above her home, she sees brilliant pink and red clouds. Nick loved it there. When she hits a certain point along the road, she feels like she's in the sky.Coming Monday in The Charleston Gazette: Doctors grapple with treating real pain vs. supplying pill seekers.This series was conceived and produced as a project for The California Endowment Health Journalism Fellowships, a program of the USC Annenberg School for Communication & Journalism.Reach Alison Knezevich at email@example.com or 304-348-1240. What are the most abused prescription drugs in W.Va.?1. OxyContin, Percocet2. Vicodin3. Xanax4. Methadone5. MorphineSource: W.Va. Prescription Drug Abuse Quitline Need help finding treatment for substance abuse?| W.Va. Prescription Drug Abuse Quitline:Call 1-866-WV-QUITT or visit www.wvrxabuse.org| Federal Substance Abuse and Mental Health Services Administration:Call 1-800-662-HELP or visit www.samhsa.gov/treatment
Preventing prescription drug overdoses: Where W.Va. stands
Keeping King�s dream aliveSeveral events set for weeklong celebration


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Here's a pretty new plug-in for the new Universal Audio UAD-2! It seems to have all the right stuff too: self-oscillation, drive control, stereo tonal shifting, good modulation options and yay a wet/dry knob. No need for me to blab too much about what it can do because there is a great video overview here:
If UA were able to conceive a Moog product, what would it be? The answer is revealed in the soon-to-be-released Moog Multimode Filter, which delivers the first truly analog-sounding VCF (Voltage Controlled Filter) digital emulation made for mixing, performing, creating, or destroying. How can we claim this? The devil is in the details …Created in conjunction with the foremost pioneers in synthesis, the Moog Multimode Filter is a virtual tabletop filter set that combines the best of Bob Moog's classic designs with select features from his final Voyager instrument. It is an amalgam of the best new and classic Moog designs, with a few innovations thrown in! – www.uaudio.com
If you want to stay native I like the Fabfilter Volcano 2 and Timeless combo.


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THERE'S a whole lot of song and dance happening at KidzWish's Shell Cove home.
For the past three years, the children's charity has run The KidzWish Music and Dance Program for Special Children.
Now, an injection of funds will result in the expansion of the already popular program.
KidzWish was founded in 2004 by Chris Beaven to provide support, love and laughter to sick, disabled and disadvantaged children.
About 15 children take part in the program's fun-filled activities each week.
The newly expanded music and dance program, funded by the Oak Flats Community Bank and Shellharbour branch of Bendigo Bank, is now under way. The branches have donated $45,000 towards the program.
The donation will enable KidzWish to make improvements to the current program, which helps to improve children's health and motor skills through social interactions.
Last Wednesday afternoon, KidzWish commenced the revamped weekly program, featuring more structured lessons and reaching more special children in the Illawarra.
The funds bought more equipment and employed a program co-ordinator and two casual staff.
Mrs Beaven said the children really responded to the musical sounds.
"Music seems to be the thing that really sets them on fire," she said. "They like the sounds of things and the comradeship."
She said it was important that parents and siblings also attended, so the children didn't feel they were on their own.
Mrs Beaven said they hoped to further expand the program to a school in the area in 2013.
The Bendigo Bank was alerted to the program by KidzWish ambassador and Oak Flats branch customer Max Lukmann.
"They look after the disadvantaged and disabled kids within our community," Shellharbour branch manager Steve Wiaczek said.
"They do so well in our community, and that's part of our ethos, to look after the Shellharbour community."
The Community Bank model means the public's banking business generates income which is distributed back into the community. The two branches have donated more than $350,000 in the past year to charities and community organisations, and $1.4 million during the past 10 years.


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Fueled by a street hustlers mentality, West Philadelphian rapper Tone Trump has turned the mantra "Let's Win!" into a motivational reference point that symbolizes his accomplishments, as well as what he hopes to achieve before he lays the microphone down. After years of working the mixtape circuit, no bigger triumph could have come than this past May, when Tone signed alongside Young Jeezy and his CTE (Corporate Thugz Entertainment) label. However, despite this celebratory event, Tone Trump solemnly stated to HipHopDX, "it's time to work for a real reason to celebrate."
In a recent conversation with DXnext, Tone Trump explained what it takes to find success within Hip Hop, how a single collaboration with Jeezy forged a new path for his career, and what he has in store for his latest mixtape The New Fresh Prince. Trump also described the direction of CTE World's compilation album It's The World, which he believes will be Jeezy's ring ceremony, ala LeBron James.
Respect Over Everything: "Honestly the most important thing that I've learned is treating people the way you want to be treated. Relationships are so important, and I believe if you show respect you get respect. Everybody that's doing their thing is gonna respect you if you're doing your thing. And one thing in my travels that I've realized is that the internet is so powerful. A lot of people forget those three 'W's' stand for World Wide Web. When we put things on the Internet, sites like HipHopDX, the whole world is seeing it. I realize I'm affecting people, so I want to project who I am and where I'm from in the right way.
I'm honored that I've had to chance to work with people that I used to have their posters on my wall, and now I'm doing music with them. It means a lot to me, and you can't do that if you aren't being respectful and creating great relationships. I'm a fan first, so I salute everybody that's doing it right now and those who did it in the past. I'm glad to just be doing my thing, and just moving with respect, dignity and integrity."
Brand Hustle: "Not only am I doing a clothing line but I'm also doing a movie that was shot in the rough streets of Flint, Michigan. It's a movie called Hard Six, and I'm co-starring in it. It just got picked up by Sony [Films], so I'm excited about that. I'm also writing a book that will be coming out around the time that school is back in session. So that'll just tell you that I came in this game as a hustler, and that's what I am more so than anything. My hustle is very versatile.
The clothing line, definitely check LetsWinKlothing.com. Forty days after starting my clothing line I got my first deal and major order with Sheik Shoes. I was in 40 malls around the country, mostly on the West Coast like Los Angeles, Las Vegas and Houston. Branding is everything to me. Everybody that I looked up to growing up did more than just music. All the dudes that got staying power did way more than just music. So you gotta follow the leaders, the ones that did it bigger than ever, and that's what I'm doing. From Will Smith to Jay-Z to 50 Cent to Young Jeezy, they did it in a way that's unmatched. I'm following their lead, and I'm excited about it."
Linking With Young Jeezy On "Afghan": I initially put 'Afghan' out as a solo record and Jeezy heard it. Someone from CTE [Records] hit me and was like, 'Yo, send it to Jeezy with an open space, Snow's gonna do a verse.' I didn't even know that was going to happen, and it winded up being something that took my career to a whole other level. The 'Afghan' record was big for me. It got me on the road, it got me on major radio. A lot of people don't realize, he did that verse for me in the midst of finishing up Thug Motivation 103 and radio promo running and touring. So for someone in the middle of all that who is a multi-platinum artist to take the time to do that for an unsigned artist, that's unheard of in this business. He didn't charge me nothing, and there was no politics. He just loved the record and had love for me, and real recognize real. That record helped change my life, as well as changed my tax bracket. I'm grateful to Snowman and the whole CTE camp for that."
Signing With Jeezy And CTE: "I definitely feel like it was meant to be. After I did 'Afghan' I had a couple offers on the table, but I reached out to Snowman out of loyalty and I said, 'I know what this record did for me. You're the main reason I'm in this position. So before I make my decision, I definitely want to involve y'all and see what's up.' And his team basically said, be patient and we're gonna make something happen, we're gonna work it out. They stuck by their word, I stuck by mine, loyalty breeds loyalty, and we got the deal done.
Honestly man, I'm on such a high with everything that I haven't gotten the chance to even sit down for it to hit me. Working with him is a dream come true. I tell people all the time in interviews, Jeezy was one of my favorite artists before we ever met or before he even knew who I was. Now being in the studio with him and working constantly and traveling with him, I'm still in awe. I'm working with the big homie, and he's bringing me around a lot of other successful artists in a short time already. I've done work with some big dogs and partied with some big dogs, and forging new relationships with other superstars. I'm forever grateful, and like I said I'm on a high right now. I've been so busy I haven't had the time to sit back. I got a lot of work to do. I want to make a bunch of money and make Jeezy and the whole CTE look like geniuses for doing this deal with me."
Still, The Journey's Just Begun: "What happens is, literally the moment Jeezy sent out the tweet welcoming me to the CTE family, everything changed. People's demands changed, my email got blown up, my phone was getting blown up, and people started expecting more from me. Friends think you got a billion dollars, family think you got a billion dollars. I got a lot of friends incarcerated, and they calling me wanting me to work miracles overnight. And with anything it takes patience. I'm hoping people understand that; a lot of people don't. I got a lot of work to do. I did a lot of work to get to this position to do even more work. That's how I look at it. It ain't no time to celebrate, it's time to work for a real reason to celebrate. I'm trying to bring a plaque back to Philly, and I can't do that by just running around being happy because I got signed. I got a lot of work to do."
On His Upcoming Mixtape, The New Fresh Prince: "I've worked mainly with my super engineer/producer Mike Jerz, who produced a bulk of the music. As far as other producers, I've been working with Warren G, Dame Grease and Lil Lody, who did like six joints on [Thug Motivation: 103]. Also Cardiak, who's on fire in the streets right now, as well as White Mike from Jersey who's been grinding. Of course Aone, who did 'Afghan.' I got Philly's own DJ Damage, one of our upcoming deejays hosting with the legend DJ Kay Slay, who's been important in my career. Shout out to Kay Slay. And it's being mixed by DJ Aktive, who's from West Philly. He's one of the best deejays in the world, everybody know about DJ Aktive.
As far as features, I kept it really close to my family. Obviously Jeezy and the whole CTE is pretty much on there. Beanie Sigel, Young Chris, Cashis, [N.O.R.E.], Mistah F.A.B., I-Know Brasco, and I got Young Savage on there who's a superstar in the making. And a super duper singer I'm excited about from Philly named Selina Carrera, she did a couple tracks as well. July 31st, I'm gonna let the music talk. I'm really proud of this project."
On CTE World Compilation Album: "All I can tell you about that is we're gonna bring something to the game that's been missing. We're definitely gonna have fun and stunt too, but we're bringing something that everybody can love, from the streets to the ladies, clubs, jails, suburbs, it's just worldly music. I feel like this is gonna be Jeezy getting his ring now. He did everything in the industry, kind of like LeBron James, and now he's putting us on, like we're his Miami Heat. Now he's getting his ring and showing he knows how to break artists and pick talent. He picked a bunch of underdogs from the streets that got real stories and real struggles, and with this album we gonna tell it. We got a ton of features, obviously I can't get into that, but everybody y'all love is gonna be on there, and it's gonna be a classic. We're also doing the It's The World movie too. It's been a dream come true working on this project. It's The World album is definitely gonna raise the bar, and it's gonna put us in that rank with all these other great camps that are putting out great music. I salute them all, but it's about to be our time."
First Single For It's The World?: "I remember when the story broke about ['Ridin'] being a single, but I'm gonna be real with you man; we've done about 15 records in the last two weeks, so the first single may still be up in the air. We was just in the studio with Ryan Leslie not too long ago, I don't even know if I'm supposed to say that. That's a HipHopDX exclusive, but we had Ryan in the studio and we made some powerful music. So if I had any say on what the first single is I'm rooting for that one 'cause I definitely wanna talk to the ladies. I can't even reconfirm if 'Ridin' is gonna be the single, but we got some great music and it's gonna start coming out soon as well as visuals."
On His Debut Album: "I feel like your first album is a document of your whole life. I've been working on that before I even signed to CTE and I'll continue to work on that. I'm saving a lot of records, even some from The New Fresh Prince that I let Jeezy hear and we've put those to the side. I wanna drop like six more mixtapes and six DVDs to strengthen my name up, and then come 2013 in the summertime, God willing, I'll be ready to drop my classic."
Leaving A Legacy: "I want to be remembered as someone who was genuine, somebody who went through the struggle and was able to see success. I really want to be somebody who gave back and put other artists on from my city, and created opportunities for people coming home from jail. I want to be somebody that was bigger than the music. There's a lot of people who hold legacies, like you look at Dr. Dre or Jay-Z, they can go years without putting out music but their names and brand remain. I just want Philadelphia to be proud, I want West Philly to be proud, and most importantly my mother and my children and my family. If I do what I'm supposed to do and stick to my plan, I believe it's doable."


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FRáNçOIS & THE ATLAS MOUNTAINS
Dividing a vinyl record between a Sea Side and River Side betrays an obvious feeling for all things liquid. On his last album, 'Plaine inondable' (2009), Fránçois sung "Be Water," a delicious and watery song backed up by a secret Basque choir. As frank as the smile given by Jean-Pierre Léaud at the very end of '400 Hundred Blows' when he arrives at the sea for the first time, Fránçois' music confronts reality and the elements which surround it lightly.
Being the first Domino French signing, Fránçois and The Atlas Mountains are ready to spread their wings over indie pop's vast international landscape. Open and extremely sensitive, these twelve songs display graceful and surprising arrangements, with their watercolour-like melodies.
With vivid looks and a slender body, Fránçois builds up castles in Saintonge with Moroccan mountains, British phlegm and sturdy friendships. After seven years of passionate gigs and road trips across Europe, Fránçois & The Atlas Mountains convey a magnetic presence on stage. A deep sense of lightness and sincerity sets in as voices, keyboards and African percussion blend in an instant pop.
An open collective, Fránçois and The Atlas Mountains has become over the years, a four-piece band. Besides Fránçois who gives the band its name and soul, Amaury Ranger embodies its vibrating body thanks to the sheer intensity of his percussive skills. A Charente activist in his own right, he's also the leader of the exuberant and promising Uncle Jellyfish. A new recruit, Scottish Gerard Black made a name for himself playing with Bill Wells and Findo Gask before joining forces with the band and leading an underground dolce vita in Bordeaux. Another Bordeaux stalwart, Pierre aka Petit Fantôme is a local musical treasure, be it under his own name, or along with The Crane Angels or Monsieur Botibol.
A mix of Italian and Bristolian, 'E volo love' stands as a superb palindrome of a love supreme flying away. These twelve songs convey a strong sense of longing and an emergency of feeling, slowly calming down once these tracks settle with subtlety in our minds and individual memories. Written between Bristol, Bordeaux and Saintes and weathered on the road and polished in Dakar they reflect a strong bond between the band's members and their relatives.
Out of the blue but into the wild, "Azrou" conveys some laid back nostalgia with its sturdy bass line and its inventive percussive work. Gazing at the countryside, "Cherchant des ponts" invites Françoiz Breut for an elegant duo with feathery drums. More urbane, "City Kiss" reminds one of The Field Mice and The Pastels heyday, watercolour bands of an intimate pop expression. Liquid, "Edge of Town" mixes African percussions with some kaleidoscopic vocals. As watery but slightly more nervous, "Piscine" is an old song, about lost afternoons spent in small town public swimming pools. Dreamy as it can be, "Bail éternel" uses Guy Debord's famous palindrome : "In Girum Imus Nocte Et Consumimur Igni" ("we spin ourselves around, through the night and we consume ourselves with fire"). This outstanding track is also a homage to writer Yann Apery's 'Diabolicus in Musica'.
More physical and less spiritual, "Muddy Heart" and "Strong Pair of Solid Arms" with their vintage keyboards display the sheer energy one can feel watching a Fránçois and the Atlas Mountains performance. Love is always the drug, as evidenced by "Slow Love" and "Do You Want To Dance?," which go deep through the hits and misses of a romantic relationship, a genuine green ray of light, the coveted light reflected in the eyes of your beloved one.
Recorded live in an old wooden dance hall of Saintonge, the backbone of these tracks stresses the instinctive nature of the recording. A sensitive mix, courtesy of Jean-Paul Romann (Tinariwen…), adds a true sense of intimacy and closeness with the listener. Airy and unruly, these chansons run down green hills, diving into an Atlantic horizon, bare foot in the grass, a big and sincere smile across one's face, eyes lost in the sunset. - Florent Mazzoleni, Bordeaux spring 2011
- Francois & The Atlas Mountains announce new album Solide Mirage, released 3rd March 2017
- Francois & The Atlas Mountains announce UK tour as special guest to Public Service Broadcasting in November
- Francois & The Atlas Mountains to play David Byrne's Meltdown Festival
- Francois & The Atlas Mountains share video for new single Fancy Foresight, out November 24th
- FRÀNÇOIS & THE ATLAS MOUNTAINS Announce New Live Dates
- Francois and The Atlas Mountains announce Franz Ferdinand support show at Somerset House
- Francois and The Atlas Mountains share The Way To The Forest video
- Frànçois & The Atlas Mountains launches brand new Piano Ombre App
This band is a collaboration with Fránçois & the Atlas Mountains / Slow Club.


text: If the Shu fits, throw it By Doug Smock October 1, 2012 Story Share Courtesy photo Marshall's Tommy Shuler heads down the field after one of his 19 receptions vs. Purdue Saturday. HUNTINGTON - Tommy Shuler's Marshall teammates knew he was getting more than a few receptions last weekend at Purdue, because that's what Shuler does.From his slot receiver position, the 5-foot-8, 187-pound sophomore from Miami runs crisp routes, hides in seams and looks for the ball from former high school teammate Rakeem Cato. Cato knows where Shuler is, and where to put the ball so only Shuler gets it.That formula worked with outrageous frequency in the Thundering Herd's 51-41 loss to the Boilermakers - 19 times for 200 yards. That was more than enough for Shuler to be named Monday as Conference USA's offensive player of the week."It seemed like every other play he was catching the ball and going for some yardage," said MU defensive end Jeremiah Taylor. "It was crazy to see him catch that much. I guess they were on [Aaron Dobson] a lot, so Tommy was the next available guy and Cato sure did go for him."I was in the training room, and I was looking at the stats, and I saw Tommy had 19 catches for 200 yards. I was like, 'Whoa!' I was looking up and asking everybody, 'Tommy really had 200 yards?' That was impressive."Even Cato, the man who threw those passes to Shuler and 26 more to other receivers, couldn't believe the count."I didn't know it was 19 catches until I got on the bus," Cato said. "I looked at my phone, ESPN [app], and looked at my phone and it said 19 catches. I'm like, 'I know I didn't throw 19 balls [to Shuler].' I don't know where that came from."He did a good job moving the chains if I needed someone to go to on third down. He's always being open, so I just took advantage of it."Those 19 catches tied the Conference USA record held by Houston's James Cleveland (2009 vs. East Carolina), and blew away the MU record of 15. Shuler had 13 in the first half and caught his 16th on the fifth play of the fourth quarter. He recorded the Herd's first 200-yard game in a decade.Suddenly, Shuler has shot into the NCAA receiving rankings. His 51 catches lead the country, and he is third in receptions per game (10.2). The top two are gentlemen Herd fans might know - Tavon Austin (12.0) and Stedman Bailey (10.25) of West Virginia. Shuler's 534 yards averages to 10.68 per game, 12th in the nation. Shuler would stack up nicely in one stat the NCAA does not compile - number of first downs picked up. Of Shuler's 51 catches, 28 have gone for first downs. He has accounted for 18 percent of the Herd's first downs, and he has contributed to solid third- and fourth-down conversion rates - 54 percent and 70 percent, respectively.And remember, he's not getting all the snaps in the Herd's rapid-fire offense. In fact, he generally goes to the sidelines when the Herd gets deep in the red zone - MU tight ends have caught eight of the team's 16 touchdown passes.But Shuler's dependability plays a big role in getting the Herd down the field."I just go out and study film, study where they're having their weak spot," he said. "I just go out there and play pitch-and-catch with Cato. He finds the open spot and we just continue to find each other."nn Herd tight end Gator Hoskins also won an award Monday, the national tight end of the week by the College Football Performance Awards.Hoskins caught four passes for 42 yards, but three went for touchdowns. He became the first Herd player since 2003 (Josh Davis) to catch three TDs in a game.His six TD catches this season is tied for fourth nationally.Reach Doug Smock at 304-348-5130 or email@example.com slot receiver Tommy Shuler's performances this season, with receptions, yards, touchdowns and first downs:Opponent Rec Yds TD FD West Virginia 5 47 1 2Western Carolina 6 79 0 2Ohio 13 121 0 8Rice 8 87 0 5Purdue 19 200 0 11Total 51 534 1 28 Story Share Story Share Trending Now 1 Facebook founder visits Cabin Creek Health Systems 2 WVU hopes to get injured defenders back for TCU 3 Teen pleads guilty to voluntary manslaughter in Oakes Field shooting 4 Congressional opioid investigation targets drug wholesaler Miami-Luken 5 Huggins, WVU tap South Florida hoops talent Texas will tone down the tempo vs. WVU Previous Story Roundup: 10 Herd hoops games on TV Next Story