text:
'); var yuipath = 'clientscript/yui'; var yuicombopath = ''; var remoteyui = false; } else // Load Rest of YUI remotely (where possible) { var yuipath = 'http://yui.yahooapis.com/2.9.0/build'; var yuicombopath = 'http://yui.yahooapis.com/combo'; var remoteyui = true; if (!yuicombopath) { document.write('
"They want to be famous. We want to be champions. They want to be rappers and backup dancers. We want to play football." - T.J. Ward, Denver Broncos
What is this perception based on?
"Freedom is nothing else but a chance to be better." - Albert Camus
"Appreciation is a wonderful thing. It makes what is excellent in others belong to us as well." - Voltaire
"Everyone's values are defined by what they will tolerate when it is done to others." - William Greider
Granger showed the Pacers loyalty. Return the favor. Period.
If he decides he'd like more money elsewhere, where the Pacers just can't afford him. Fine. But let him make that decision. It's just the right thing to do.
You're taking this loyalty thing way too far.
I'd rather they do the right basketball thing, whatever that is. It's a business, not a charity.
And like Pacers4ever said I'm glad you are not the GM doing business with your heart is not good business.
@WhatTheFFacts: Studies show that sarcasm enhances the ability of the human mind to solve complex problems!
follow me @TruenoPanda - lets talk Pacers!
Actually that kind of basketball was pretty beneficial for him, he became an all star because the clown let him do whatever he wanted to do, the clown did not care about him jacking up shots and not playing D.
@WhatTheFFacts: Studies show that sarcasm enhances the ability of the human mind to solve complex problems!
There is certainly a business reason for reducing salary, so sadly Granger might have to go.
But trade him to reduce the risk of Granger being a cancer in he locker room? That has to be one of the most ridiculous statements I've ever seen posted here on the forum. Or, did you simply not watch games and follow the team during the past season?
I think what I've found so far with Bird is that you can take him for his word. I think I'll stick with him on that unless he proves otherwise. He said he's not trading Danny and wants to keep this core together. It's the right thing to do and the best basketball move to make considering what a healthy Danny Granger brings to this team versus what his trade value is right now.
I doubt that he's being shopped by the team but with his absence while the team is succeeding Granger's risk of being traded is the highest this year. But I hope he's not traded simply because I think he can still contribute and this coming season is one of the best chances to win a championship.
And in terms of loyalty and business, I think there's a double standard here. If he's a superstar fans want him to be loyal and they'll diss him when he leaves or tries to but when he's just an average to above-average player fans either don't care if he's gone because of business perspective or they'll be the ones pushing him to be gone even if he's loyal and truly loves to play for the team. Not really favoring one side but let's just be consistent with our stand. If at some point one of our young stars decided to leave or ask a trade and join other teams, I hope I won't hear those "less emotionally attached" guys to bash them for having "no loyalty" to the franchise, because players too think of their profession and business, not just franchises and fans.
I'm tempted to sticky this thread for use later this year or better yet next year.
I'm not even mad or upset because all I'm doing is sitting back watching some of you twist in the wind getting all hopeful that Danny will be a Timberwolf, Pelican, Bobcat or whatever other team.
From the Danny fan club perspective when Bird came back this became an almost no lose situation for us. Why? Simple even we will admit that right now he has little to no trade value and the team is not going to take back salary, even young talented salary knowing that they have to pay Paul & Lance soon. So they aren't going to move him now.
But what about if he plays well enough to be moved by the trade deadline, you might ask. The only chance this happens at all is as follows, if Danny is doing well but the team is struggling. That's it, that's your only hope and frankly if your hoping for that then I question your loyalty to the Pacers. But conversely if he plays well enough to be traded and the team is doing well, he won't be traded. They are not going to break up a good thing.
If for whatever reason he is unhealthy again this year I would not put it past Danny to retire. But even if he doesn't the team will ride out his expiring contract.
Danny Granger will be a Pacer for the 2013-14 season.
So whether you like or whether you don't like it, learn to love it because its the best thing going today.
Not a lot to hate when we know he won't be back next year anyways, in other words enjoy him while he is here because he is not going to be here that long.
Last edited by vnzla81; 07-03-2013 at 12:23 AM.
@WhatTheFFacts: Studies show that sarcasm enhances the ability of the human mind to solve complex problems!
Also what I love the most is, even though you hate it, you know I'm right. Danny is here one more year and in that year all that I want out of life (well other than a Pacers title) is for him to score 252 points and pass Jermaine O'Neal on the all time scoring leader board for the Pacers. If things work out right he should end up 3rd all time this year and sadly (for me anyway) that is where it will end, but hey that's still pretty good company.
By the way I'm starting to question the loyalty of some around here hoping that the Pacers keep a player that is making 14mil and don't do anything to move him just because they love and have a mancrush on this player, they rather see the Pacers fail and watch this player on the bench than to use that money in something that could help the Pacers win a championship.
Shame on some of you that hope the Pacers retain him even if he is sitting on the bench.
@WhatTheFFacts: Studies show that sarcasm enhances the ability of the human mind to solve complex problems!
It won't be the first time somebody does that to me, it looks like I'm the only around here that is held accountable.
@WhatTheFFacts: Studies show that sarcasm enhances the ability of the human mind to solve complex problems!
But Granger has taken less and less shots each year with Vogel. He has said that this is Paul George's team now.
I didn't heard Wells podcast but everything that I've read so far indicates that he has no problem being the second / third fiddle.
Tonight, all flags must burn, in place of steeples.
Autonomy must return into the hands of the people.
That's what I want to happen with Granger as well. Win a championship first and trade him later
Tonight, all flags must burn, in place of steeples.
Autonomy must return into the hands of the people.
Tonight, all flags must burn, in place of steeples.
Autonomy must return into the hands of the people.
Danny is unmovable until he returns from injury. No team is going to give out assets for a player that is a current question mark.
So, moving now would be an extremely stupid basketball decision because it would guarantee that we would be getting low-balled.
We need to wait until Granger returns from injury and shows that he's capable of being at least 80% of the player that he was.
If he does that then he also happens to be the perfect fit for our team since what our team lacked this season was Danny's specialty, 3 point shooting.
At this point, it's probably stupid on my part to try to reason with you regarding Granger but seriously. Do you not see that a healthy Danny would be amazing for this team as it would guarantee us scoring off the bench? Are you blind? Is your hate for Danny so big that you won't be happy if win a title just because Danny will be there as well?
I mean, seriously..
Tonight, all flags must burn, in place of steeples.
Autonomy must return into the hands of the people.


text:
Hello Belci Bye Kitty Long-sleeve T-Shirt
Product Color:
Product information
The Long-sleeve T-Shirt Hello Belci Bye Kitty is the long sleeve version of the popular favorite t-shape. It provides comfort and control over most weathers and can also be worn underneath a t-shirt or a shirt for extra protection.
Put Hello Belci Bye Kitty on the finest combed jersey which feels soothing against your skin. Shoulder-to-shoulder taping guarantees long life and a good fit. Belci Long-sleeve T-Shirt is available in 10 different color options. Heather Grey: 80% Peruvian Cotton 20% Polyester, Remaining Colors: 100% Cotton.
Sku: LW1WH0000008781818180445BLRE00000

subset: commoncrawl


text:
Auctioneer earns repeat trip to world championships
EUGENE, Ore. - Even when the Eugene Livestock Auction Center is empty, his voice can fill the room.
Jake Cheechov recently qualified for his second World Livestock Auctioneer Championship. He finished 16th in the world championships in 2009.
While the words can sound like a blur, auctioneering is not just random babbling with a few numbers thrown in.
"In your auction chant, you want to use what you have and what you want to communicate effectively to your audience," Cheechov said, "where the bid is at and where you want the bid to go."
He has to keep the flow going, and the rhythm of the cadence is more important than speed.
"When you're on, it feels good," he said. "It's an amazing feeling when everything sort of comes together.
"It takes years to get to the point where you have a lot of rhythm."
Cheechov's auctioneering started as a senior class project in high school. Then it was off to college.
"As it turned out, the major that I'd chosen in college was a lot tougher than I had envisioned," he said, "so I started working auctions."
Now with the live auction business in decline, competitions like the world championships are vital.
"To be able to return again this year is just, is truly good for the industry," he said, "and good for me."


text:
Ron Howard Photo 349x450
Ron Howard
Ronald William "Ron" Howard (born March 1, 1954) is an American actor, director and producer. He made film appearances such as in American Graffiti in 1973 and while starring in Happy Days he also made The Shootist in 1976, as well as making his directorial debut with the 1977 comedy film Grand Theft Auto. He left Happy Days in 1980 to focus on directing, and has since gone on to direct several films, including the Oscar winning Cocoon, Apollo 13, Frost/Nixon, A Beautiful Mind and How the Grinch Stole Christmas. In 2003, he was awarded the National Medal of Arts.
Recent news
Selena Gomez Needs Help to Find Australian Boyfriend
Halle Berry is Fine after Divorce
Gwen Stefani Opens Up about Life before her Divorce
Subscribe to our weekly celebrity newsletter and receive the week's trending celebrity photos and wallpapers.


text:
Geez, Whatll They Do For An Encore?
So how much horsepower does it have? he asked, eyes wide and eager. Three hundred and ninety, we replied. Wow! And that Michigan tag. Are you from Michigan? I just got here from Ohio.
No, we live here. The cars straight out of SVTit belongs to Ford, we grimaced, as his face slowly jelled with incomprehension. Thus it went with the young salesperson at a large Ford retail store.
Reaction was pretty much the same all over. This Sonic Blue king of Cobras got barely a glance from anyone on the road. To them, it was just another Mustang with big tires, the millionth in a sea of Mustangs. And thats not a bad thing, either. An edgy car like this needs anonymity for obvious reasons. Even the cop we whizzed past at 15 over the limit made like it wasnt there. Well, fie on them and chalk one up for the stealth club. A few minutes later we were wailing the wee out of the Cobra, taking 30-mph turns on the snake-like Ortega Highway at nearly twice that speed.
Like all Mustangs since the first one, the Cobra does not attempt to dazzle you on the inside. Its composed, straightforward, and the controls are easy to access and operate. Everything is right where it should be, a patented arrangement that can be accessed in utter darkness with complete accuracy.
Besides the usual engine monitors, the Cobra supplies you with a half-dollar-sized boost gauge for the first time since the turbo four-cylinders of the 80s, but its so like the other meters that it basically goes unnoticed, especially when youre whipping the engine good. The blower spools up so fast you havent the time or the inclination to see where the needles going because youre too busy watching the one on the tachometer bend ferociously to the right.
The Cobras articulated seats feature an extra-firm bottom, lumbar support, and grippy, adjustable thigh bolsters. These seats are leagues better than, say, the GTs of the late 90s, and we see no reason you wouldnt be comfortable in them for days at a time. Adjust the tilt steering column to fit, crank up the Mach 460 audio to suit your mood, and go trolling for mincemeat.
Aside from the black-on-white instrument faces, the only flash in the cockpit is the perforated brushed-metal finish plates that accent the foot pedals and the shift-pattern marker on the end of the stick. The Cobras cozy cockpit is honest and understated, fits the driver well, and works to potential without a frill or geegaw to compromise its mission.
Ride & Handling
The closest thing to the Cobra in Ford terms is the limited-production 2000 Cobra R, which is not something youd want as your main source of transportation. While the R handles like the race car that it is and is a cool operator on a smooth-track surface, it does a pretty good job of beating you up on public roads. Its noted for a distinct lack of ride compliance and will shake your guts and make the shoulder harness bite. The Cobra makes a tad more power than the R but is dialed for the street rather than the racetrack so its Bilstein ride is a bit gentler (a relative term here) than say the Hotchkis/Tokico suspension in the HOT ROD 97 Mustang.
In short, the chassis is tuned for high-rate handling as well as straight line bashing, and this largess is due in large part to the independent rear suspension. Changes to the IRS include revised rates for the bushings, mounts, and springs. A new tubular crossbrace is attached to the differential housing and is designed to stabilize the assembly under hard acceleration (high-rpm clutch dumping, flat shifts, other fun), and revised suspension geometry improves roll steer. Though the 600-lb-in springs all around sound hellish for the street, the car rides like it has half that rate going on beneath, due mainly to its relatively high mass. The Cobra Coupe weighs nearly 3,700 pounds, and the heavier, more complex rear suspension and the iron cylinder block account for at least 200 of them.
All that bulk evaporates when you thread the Mustang into a blind curve. Body roll is minimal, and those big, expensive, and exceptional Goodyear F1s dont even whimper. The transitions, in turn, are very smooth and very linear. You just gun the snot out of the engine on the straight parts, apply the big Brembos in the last few seconds, and steer the car through without drama. To keep the lawyers happy, that neutral attitude ultimately descends to mild understeer.
The steering maintains just the right amount of resistance and is weighted nicely to the dynamics of the chassis. To obtain this sensation, the SVT team put in a low-lash intermediate shaft and a higher rate steering-gear bushing that improves feel by reducing the play in the system. On the highway, those F1s are extremely quiet and all you really hear is the whine of the supercharger. The ride quality is very acceptable for the moment with no harsh inputs, and it tempers our favorite head-bumping freeway humps well within reason. In all, the chassis lends amazing control over smooth surfaces, and it wont disturb your kidneys over rough ones.
To complement the 70hp-stronger engine and heavier curb weight of the new Cobra, SVT employed vented discs in the rear as well. The 11.65-inch rears and calipers incorporating a revised pad material balance the Brembo rotors and PBR dual-piston calipers up front. The pedal is easily modulated, and the pressure required is minimal. Pedal feel is excellent and its height is relative to that of the throttle, thus enabling easy and fluid heel-and-toe action, which returns the smoothness necessary for consistency. We couldnt make them fade after repeated haul downs from 60 mph or on the constant short-straights and switchbacks of the fabled Ortega. The Goodyears have grown by a bunch of millimeters, too, with the 275-section tires in place of the previous 245s. To accommodate them, the 17-inch wheels are wider by an inch.
The throttle is what gives us goose bumpsalways has, always will. Before we get into the wheelspin stuff, lets look at the way the supercharged engine performs its daily duties. A couple of times we spaced it and left the stop sign while the tranny was still in Third gear. With minimal throttle and an 8.5:1 compression ratio, the engine simply grunted off with barely a protest from the clutch or transmission. It will lug around at 1,500 rpm in Sixth if need be and the tranny wont snatch or clank. Though probably the result of a too many hard, missed shifts (our car had 4,000 journalist miles on it), the shifter often had a time finding Third gear, especially when it was downshifted.
From the very beginning, the lack of low-end torque has hampered the four-valve engine. Put it in perspective then. Its working with 280 ci, not 350, and four small valves instead of two large ones, so it takes a little time for the power to ramp up. And thats one solid reason why people put superchargers on them, especially the Roots-type that develops maximum boost way down in the rpm range. This combo on the Cobra motor is pure dynamite. The low-end response is enhanced thusly, and by the time youre on the far side of Third, be ready for a rush so real that youll soon be finding out just how efficient those Brembo brakes really are.
The power comes on more like a missile launch than a prison break. Its smooth, linear, sophisticated, and quite unlike that of the naturally aspirated Chevrolet LS6, and it represents a successful combination of low-end blower torque and high-end four-valve breathing. As such, the upper and lower halves of the intake manifold are opened up for increased airflow to the heads and the cams were ground with torque in mind. Even the heads are modified to move more air and increase the low-end without sacrificing peak horsepower. Adjunct to this, the Cobras 2.25-inch tailpipes help to keep it within the noise regulation bogey and provide some backpressure necessary to produce that needed low-end torque. But you can lay odds that the aftermarket exhaust companies will spasm to be the first out with 2.50-inch after-cat pipes and claim 20 extra horsepower or so.
As for hard data, we proved the Cobras rear-wheel power on Superior Automotives chassis dynamometer and found 369.5 hp at 6,200 rpm and 362.2 lb-ft of torque at 4,000 rpm. With the G-Tech, we clocked 0-60 in 4.8 seconds and 60-0 in rather disappointing 134 feet. On the long course, the Cobra pounded out a best of 12.93 at 114.50 mph! In this, the most refined Mustang chassis in history, 80 mph feels like 60, the car will reach nearly 100 in Third gear, and the blower whine is something that you hear in your dreams.
What It Is
Take a good long look at this Mustang for it is the last and strongest of its breed. The next generation, due as an 04½ model, will adopt a shortened Lincoln LS platform and incorporate variations (variable cam timing and so on) of the current powerplants. Perhaps the performance-oriented Mustang will then move from its present niche to inhabit one more sophisticated and thus more expensive to produce and to own. Among its salient points, a solid rear axle (the IRS will appears a couple of years later) and (gulp) an engine controller that will be extremely difficult to crack.
For the time being, the current Cobra is a lot more fun than you should be allowed to have sitting down. And when the BS begins, you lift that fresh-air-inducted hood and watch the troops go snap, crackle, and pop.


text:
Posted 7 years ago
(1 item)
I have just aquired this flag pennant I found in a old house that was abandoned. I think its pretty cool but am interested what the value might be. Its pretty faded but the graphic are in excellent shape. From the back side it used to be a dark navy blue felt but the front has faded towards a light purplish grey. I can't find information on the internet about it but maybe I'n not entering the correct information.If anyone can add some input on its value or history it would be very much appreciated!
Please email firstname.lastname@example.com if you can help


text:
The Denver Outlaws will host a summer lacrosse camp that will run July 1st-3rd at Denver South High School, the team announced on Thursday.
Instructors will include Outlaws attackman Chris Bocklet, defenseman Matt Bocklet and other players to be announced at a later time.
Chris Bocklet currently leads Major League Lacrosse with 15 goals and Matt Bocklet, who is a two-time MLL All-Star, is tops among all non-faceoff men with 25 ground balls. Chris is the offensive coordinator for Wheat Ridge High School, which just earned the 2013 Colorado High School Class 4A State Title, and Matt is the head coach of the varsity lacrosse team at Highlands Ranch High School.
The camp will run from 9 a.m. – 12 p.m. each day and is open to boys from 6-9th grade at a cost of $150.
Each day of the camp will feature other Outlaws players and coaches with prize giveaways and autographs available. There will be plenty of scrimmaging and game-like situations to sharpen skills. The cost of the clinic includes an Outlaws pinnie and a ticket to an Outlaws home game. Campers are required to provide their own lacrosse equipment as well as water and snacks.
For more information and to register, visit


text:
Posted 7 years ago
(1 item)
I got this pack in the effects of an uncle who died 15 yrs ago I thought they were just a regular pack of old vintage playing cards and was about to flog them.
On closer inspection I noticed that they were imperfectly cut, not immediately obvious or distracting and I thought this may have been normal for the time.
However I'm now wondering if this is a "trick" deck because as you'll see from one of the photos I (non magician) discovered that by tapping the deck I can get a card to just edge out of the deck......and it just so happens to be the Ace of Spades!
So how can I TELL if they are a trick deck, or if its a just coincidence from a badly cut deck....and if my uncle was a card sharp!


text:
Police: Man gave Oreg. high school girls illegal tattoos
SPRINGFIELD, Ore. - A man faces charges he gave tattoos to high school girls in violation of Oregon law.
Eugene Police arrested Brett Allen Breding, 20, of Crow on 8 counts of tattooing without a license and 8 counts of reckless endangerment.
Breding does not possess a state license to tattoo, said police spokeswoman Jenna McCulley. The reckless endangerment charges stem from the risk of spreading infection via illegal tattooing, McCulley said.
It is also illegal in Oregon for anyone under 18 to get a tattoo.
So far, police have identified 8 girls under 18 who allegedly got tattoos from Breding. Police suspect there may be other people who got tattoos from Breding. She asked anyone who got a tattoo from Breding to call (541) 913-9671.
McCulley said police had heard Breding was giving tattoos to minors as far back as September 2011 but couldn't find any victims.
About a month ago, a Thurston High School parent told police in Springfeidl that Breding had given her daughter a tattoo.
Eugene Police got involved after the investigation led police to private homes in Eugene where the tattoos were done, McCulley said.


text:
|Energy RC50 Reference Connoisseur Series Tower Loudspeaker - BLACK ASH
|No reviews have been added.
|Related Conversations
|There are no related topics.
No members have owned this product.
Energy RC50 Reference Connoisseur Series Tower Loudspeaker - BLACK ASH
Description: If you live for your music, movies or games, the RC-50 is your speaker. These towers deliver massive sound and a great look that works anywhere you put 'em. Rocking out or winding down, the RC-50 makes great audio come alive. Rosenut finish on a high-gloss black base matches audio, gaming and video systems Deep bass from two 6.5-inch Ribbed Elliptical Surround woofers Bone-chilling highs from aluminum dome tweeter help you hear details you never noticed Ideal for medium-to-large size rooms where you want plenty of power and volumeThe lowdown: Like the flagship RC-70, The RC-50 is a world-class performer, no matter what you listen to. And, they're as cool to look at as they are to hear, with two finishes-rosenut and black ash, all on a gloss black base-and in a cabinet that looks cool anywhere. Pop the grille and what you see is Pure Energy: from the crystal-clear 1-inch dome tweeter to the 6.5-inch KevlarTM woofers, there's enough power to slam you back in your chair. Ribbed Elliptical Surround technology cuts distortion, so all you hear is audio the way it was meant to sound.Technology: Bragging rights: The Reference Connoisseur RC-50 features classic Energy design: Flat On-Axis Frequency Response with Wide Bandwidth: Speakers should reproduce the entire audio range in a uniform manner. By ensuring that no one frequency dominates any other, Energy ensures that every note is the way it was intended to be-and the sound as natural as possible. Wide and Constant Dispersion:


text:
And in the Feel Good News Dept ...............
Louisville's Kevin Ware played Wednesday in his first game since suffering a gruesome broken leg 220 days ago against Duke.
Ware entered the exhibition contest against Pikeville at the Yum! Center to a standing ovation. He made his first shot, a 3-pointer, and finished with six points and four rebounds in 10 minutes.


text:
Dodds has been with Virgin Media since March 2009, and became executive director of brand and marketing communications in June 2011.
The CMO position was created with Gilbert's arrival in January 2011, during which time he has helped integrate the company by establishing its customer marketing organisation, which brings together commercial strategy, customer insight and experience and brand and advertising.
Under this new structure, Virgin Media's marketing team has been active throughout the past year, with high-profile campaigns starring Usain Bolt, David Tennant, Mo Farah, Stephen Fry and Sir Richard Branson.
Andrew Barron, chief operating officer at Virgin Media, said: "I'm delighted Jeff is our new chief marketing officer. Jeff has delivered some of our very best campaigns and genuinely outstanding advertising.
"Orchestrating high-profile work and sponsorships such as Virgin Media's V Festival, 'Britain's Got Talent' and Virgin Media Shorts, Jeff has ensured we're always front of mind and makes our customers and staff proud to be with Virgin Media. I look forward to his continued creativity and leadership."
Before joining Virgin Media, Dodds was director of brand and marketing for Callaway Golf and, prior to that, he spent five years at Honda.Follow @DurraniMix


text:
Trying to lock down a bag for my spring tournaments. I'm going to try and get by on just these ten discs and not change it around for at least a month. I can throw my solfs about 400' and my mids get out to 320' pretty easily.
2x 170 Soft Wizards - Putters
170 Eclipse Ion - Understable Putter
170 ESP Zone - Overstable Putter/Mid
174 CE QMS - Understable Mid
177 FT KC Glow Roc - Stable Mid
159 FT 12x Firebird - Overstable Driver
164 1.1 SOLF - Understable Driver
166 1.1 SOLF - Stable Driver
170 S Scorpius - Overstable Driver
These discs all ride in an Innova Standard bag that has been Plasti-dipped and equipped with Quadshocks. I really like how light it carries and how it leaves me feeling less drained at the end of long golf days.


text:
Lenders in Gatesville, NC
Find a Local Lender - Mortgage Lenders, Hard Money Lenders & More in Gatesville
Choosing the right Gatesville lender isn't always an easy choice to make. That's why we provide consumers with a comprehensive search directory of lenders in Gatesville , including mortgage lenders, hard money lenders, auto lenders and more. We simplify the process by putting all of your lending options all in one place. Get started now - browse the detailed listings below to learn more about lenders in Gatesville, NC.
We're sorry, there are currently no listings for this city. Please click here to search again.


text:
Storm Team 27: Showers will taper off this evening
The latest weather forecast for Youngstown, Ohio and surrounding areas.
The latest weather forecast for Youngstown, Ohio and surrounding areas.
Lordstown plant manager Steve Notar Donato said the new Cruze should be available in the spring of 2016.
A Jackson County couple is in mourning and a trash collector is out of a job.
The Los Angeles Times says Selleck grows avocados at the ranch.
Police said Wednesday they were investigating video that appears to show Ariana Grande licking doughnuts at a shop in Southern California.
They didn't speak for 15 years. But thanks to a viral video a Sarasota homeless man reconnected with his son.
Impacted workers will receive a severance package, according to a release.
The Coyotes begin the league slate on October 3 when they welcome Youngstown State.
The office was made aware of the photos on Wednesday.
The latest weather forecast for Youngstown, Ohio and surrounding areas.
A creek in New Sewickley Township went over its banks. The water surrounded several homes and flooded a road.
More than 50 years after South Carolina raised a Confederate flag at its Statehouse, lawmakers are getting ready to remove the rebel banner.
When crews arrived, the house was engulfed in flames.
Murphy came through with a two-run double with one out in the eighth inning to send Cleveland to a win over the Astros.
Pittsburgh completed its 10th series sweep of the season, which ties a club record.
Paramount called the plan one that "could potentially redefine home digital distribution."
In the weeks following the accident, Budd underwent multiple surgeries, including a lengthy procedure to replace a section of her skull.
Creating those standards is the job of the Ohio Collaborative Community-Police Advisory Board, which met for the first time Wednesday.
Those attorneys also represent Michael Hoyt, a man charged with threatening to kill Republican House Speaker John Boehner.
Fair Districts for Ohio formally launched its campaign Wednesday with support from a who's who of Statehouse interest groups on right and le…
The latest weather forecast for Youngstown, Ohio and surrounding areas.
Bentley Lenhoff died early Wednesday morning following a brief battle with cancer.
Important Notice About Our Privacy Policy: We have modified our Privacy Policy to update and clarify our data collection, use, and disclosure practices.
By using this site, you agree to the updated Privacy Policy and Terms of Use


text:
Don't leave your pet at home when you go biking - take her along in this comfortable, shaded basket. Authentic rattan design travel basket features a removable sunshade, combined with breathable construction, to keep pets cool and comfortable. Lambswool liner cradles pets in comfort and is easily removed for washing. An adjustable safety leash keeps pets secure while riding.
This dog bicycle basket features a unique bracket system, so it's easy to take the basket on and off a bicycle in seconds with just one hand. Three-way adjustability on the bracket allows for a good fit on any bicycle, without interfering with brake cables. Holds pets up to 13 lbs. Inside dimensions of basket are 15" x 11" x 9.5" high; basket weighs 4 lbs. Brown wicker.
Downloadable Tagalong Wicker Bicycle Basket Assembly Instruction PDF. Requires Adobe Acrobat Reader 4.0 or later - get it here for free)


text:
What's the difference between a Holstein and a Longhorn?
According to Chevrolet's latest Silverado commercial, the answer is "nothing."
"A man and his truck and a broken fence. And a lost calf. And the heart to search for as long as it takes. And the truck that lets him search for as long as it takes," the commercial's narration says in the 30-second clip.
Click the video player above to see the commercial or here to see it on YouTube.
The storyline features a hardworking rancher who, while checking his herd of Longhorn cattle in the midst of a rainstorm, finds a calf missing. With the help of his 2014 Chevy Silverado, the rancher finds his calf – a Holstein calf.
This storyline may tug at the heartstrings of the general public, but farmers and ranchers will likely see it differently. A quick look on the truck's YouTube and Facebook pages shows that farmers and ranchers aren't letting Chevy off the hook.
"Yep, that is a Holstein. Silly Chevy," one Chevy fan commented on its YouTube page.
"Chevy I have nothing against your trucks but this is pretty sad. You show Longhorn cows and then a Holstein (aka dairy breed) calf. The idea is inspiring and as a rancher I have spent many times looking for a lost calf and salute those who do this for a living but you could have done just a little homework to give this some reality and make this not look like a failed attempt to answer the Dodge "And God made a Farmer" commercial which had some reality issues of its own," another person commented.
The commercial is only the latest in a series by Chevy to feature rural America. However, as rancher Ryan Goodman wrote in a blog post, the first of Chevrolet's ads fails to have the "emotional, pull-at-the-heart-strings response" as Dodge Ram's "So God Made a Farmer" Super Bowl commercial.
Dodge Ram's now-iconic commercial not only declared 2013 the "year of the farmer;" it also pledged to donate to the National FFA Organization for every view for its advertisement. It took less than a week to reach 10 million views, earning the FFA a $1 million donation.
Other pro-agriculture car commercials include the Toyota Tundra and Ford F-150.


text:
Could the worst drought in 50 years finally be showing signs of weakness? Thanks to a burst of rain and snow in many Crop Belt states, the drought is finally showing some signs of improvement.
Currently, 51 percent of the Lower 48 is in moderate or worse drought, and though it may be far-fetched to applaud half of the country still in the grips of drought, it is still welcomed progress. According to the latest Drought Monitor report released Thursday morning, the last time 51 percent of the nation reported moderate to exceptional drought was in June 2012.
Improvement or, in some cases, shifting drought conditions, were noted in states most affected by the drought:
- Kansas: Rain over the weekend wasn't a drought buster, but as a result of the welcomed moisture, 65 percent of the Sunflower State is now in extreme or worse drought. This is down considerably from last week's report of 70 percent. The biggest story in the state is that moderate drought as returned to eastern portions of the state – moderate drought, one of the lowest levels reported by the National Climate Center, was last reported here in July.
- Nebraska: The Cornhusker State has been blanketed by dark hues of red and maroon on the Drought Monitor report since early fall, but February's impressive snowfall totals helped move drought conditions slightly lower. More moisture last week has helped to push drought conditions slightly lower. Extreme drought conditions in the state dropped by less than 1 percentage point to 76 percent.
- South Dakota: Of all the states, South Dakota has reported the biggest shift in conditions. Exceptional drought dropped by 10 percentage points to 20 percent, and as a result, extreme drought conditions, one level of intensity lower, increased by 13 percentage points to 47 percent.
- Oklahoma: The Sooner State is split nearly in half by drought conditions. Overall, 57 percent of Oklahoma is in extreme or worse drought, down from 62 percent last week. However, the western half of the state is bearing most of the extreme and exceptional drought. The eastern portion is dominated by moderate to severe drought instead.
See how your state is doing here.
So while the drought is far from ending, it is shifting in the right direction. March has come in as a lion for many key agricultural states, and producers can only hope that the wetter weather pattern will keep up.
According to Bloomberg, AccuWeather senior Meteorologist Paul Pastelok suggests that the wetter weather may stick around for awhile and aid with upcoming crop planting.
"The weather pattern is more favorable than last year, when warm, dry weather from March to August wilted crops," Pastelok said in a telephone interview. "We expect ample moisture during most of the growing season from southern Texas to New York."
Pastelok also warned that there will likely be a few hot and dry periods in June and July for parts of the Plains, including Nebraska, Kansas, Colorado, South Dakota and parts of Iowa and Minnesota.


text:
I have lots of javascript alerts throughout my site, I need to style them up using a jquery dialog. Can anyone please tell me how I can setup a default dialog and populate it with the alert text?
A typical alert looks like this:
window.alert("text here");
My current dialog looks like this:
autoOpen: false,
width: 400,
modal: true,
closeOnEscape: true,
buttons: {
"Log Out Now": function () {
window.location.href = o.logoutUrl;
"Stay Connected": function () {
Can I set the defaults such as width and close on escape so I don't have to keep adding them for each instance, there are literally hundreds.
Many thanks in advance
Hi there,
Are you asking if it is possible to change the behaviour of window.alert(), so that it opens in your jQuery dialogue instead of the browser's native alert box?
Hey Pullo,I think it's gone viral that SPF is the place to get widgets! :lol:
But in truth, I think he may be looking for this: http://jqueryui.com/dialog/#modal-message
Hey myty,
Sure has.We've just got to work out how to monetize it and we're made
I thing something like jQuery UI Dialog is the way to go, but I understood the question to be that he has a load of alerts (hundreds) and he is looking for a way to have them appear in jQuery modal by just flicking a switch.
As far as I know the only way to convert them is by hand (or with a scripting language if you have access to the source files).
Anyway, maybe I misunderstood the question, so pray enlighten us Sir mattastic.
You can always assign a new function to window.alert in order to override the one built in.
Getting the code to pause at that point and not run the following code straight away is more difficult. I worked out a way to altomate the rewrite of the script where all of the code is executed sequentially but loops makes it far more complicated.
See http://www.felgall.com/jstip113.htm for more info on replacing alert() with your own custom code.
So you could do something like this:
window.alert = function(message){
I hadn't thought of that.Thanks, Felgall!
You could but you shouldn't. I don't recommend this at all.
Because of that, there is no protective mechanism for Array, or Function. One could replace these constructor functions and completely change the way JavaScript works.
However, when it comes to replacing existing objects and properties, the rule is... don't. Especially when it comes to the native part. Namespaces and modules should be on your mind, not replacing or extending the native objects.
Fair enough.Would there be an acceptable way to go about this then, presuming that the OP wanted to hijack the window.alert function?
No hijacking, I'm afraid.
Well, if the OP would hijack windows.alert, and a third party library it uses would also hijack the windows.alert, and another third party library it uses would also hijack the windows.alert, the site functionality soon starts to resemble a black hole where no one can tell for sure what happens inside.
Anyway, until the OP points the site, for me it's not clear what its intentions are.
Given that window.alert(), window.confirm(), and window.prompt() now serve no purpose whatever in JavaScript the only danger in overriding them is as you say if multiple scripts were to override them.
By overriding them LAST in the JavaScript you attach to the page you can ensure that your particular choice of how they are overridden would take precedence.
No library should be using any of these long dead calls so the only time you'd have the sort of problem you are suggesting is if you are using an antiquated library - but they would be unlikely to be trying to override any of these obsolete methods because when the antiquated library was written the method wasn't obsolete.
Given that no modern library would use any of these, it should be reasonably safe to override them for your own use.
The situation would be entirely different if the discussion was about JavaScript built in methods that are still used. The argument you put forward for not overriding built in methods definitely applies to all of the ones that JavaScript still uses.
The only reason that overriding alert() can be considered is that it is long obsolete. The last browser to require its use in live scripts was Netscape 4 and now that all browsers have a built in debugger it is no longer needed for debugging - so there is no longer any circumstances where it should be used - unless you override it with your own replacement.
As the OP demonstrates, alert is pretty much alive and kicking, not the road kill you make it to be.
Relying on things like being the LAST to override a method is a Las Vegas table scheme, not real programming.
Precisely because of the modern state of affairs in JavaScript, one should not even consider this hijacking technique.
alert() was replaced by console.log() and the built in debugger last year when Firefox finally added a built in debugger (as all the other browsers already had one).
You seem to have a theory but I'm not so sure it holds out in the real world.
The Microsoft IE11 team seem to have missed the memo about alert: http://msdn.microsoft.com/en-us/library/hh924508%28v=vs.94%29.aspx
Interestingly enough, they are right in using window.alert instead of just alert, as a sign that they respect native JavaScript and expect others to do too. Meaning don't hijack it, create your own.
And apparently so did the MDN folks: https://developer.mozilla.org/en-US/docs/Web/JavaScript/Introduction_to_Object-Oriented_JavaScript
Two highly representative sources, and in sections with advanced topics.
And I'm 100% sure the "Hello World!" starter program in JavaScript it's still alert("Hello World!").
You keep coming back to alert as a debugging method. It's not, at least not recently, not with IE8 Developer Tools, or Firebug, or DragonFly, and certainly not now, with Chrome DevTools or Brackets.
You keep coming back to Netscape 4. I believe that this is a big big stretch. You should just drop it. The web and JavaScript world too have moved way beyond this.
The only reason that those commands haven't been flagged as obsolete in the JavaScript standards is that they have never been a part of the standard in the first place. You can't remove commands from the standard without adding them first.
No - that's what it was 10 years ago as the replacement for document.write('Hello World');
Now the Hello World starter program for JavaScript uses innerHTML instead as the following two tutorials show.
Mixing up bad practice (innerHTML for adding content) with seriously unreliable sources (I mean, you're attempting to trump my Microsoft and Mozilla with your w3schools! COME ON!) is really not helping your argument.
Especially when your own w3schools is using alert for Hello World!http://www.w3schools.com/js/js_functions.asp
Security considerationsIt is not uncommon to see innerHTML used to insert text in a web page. This comes with a security risk.
However, there are ways to execute JavaScript without using <script> elements, so there is still a security risk whenever you use innerHTML to set strings over which you have no control.
For that reason, it is recommended you not use innerHTML when inserting plain text; instead, use node.textContent. This doesn't interpret the passed content as HTML, but instead inserts it as raw text.
Security Warning: Improper handling of the innerHTML property can enable script-injection attacks. When accepting text from an untrusted source (such as the query string of a URL), use createTextNode to convert the HTML to text, and append the element to the document using appendChild. Refer to the Examples section below for more information.
alert is a toy everybody agrees and understands. Reason enough to not hijack it. Which is the point from which I got sidetracked with code politics nonsense and debugging techniques misdirections.
W3 Schools is still in the process of replacing antiquated pages such as that one. The page I linked to is the very first script they offer and is one that they have updated. I only linked to that to show that even really antiquated sites such as w3schools are getting rid of their alert() pages now.
I'll trump the Microsoft and Mozilla sites with the ECMAScript standards site - which does not acknowledge that JavaScript has ever had an alert() command. Since that site is THE standards for JavaScript it is the final word - http://www.ecma-international.org/ecma-262/5.1/ - try searching the standards for alert() and you will not find a single reference to such a command ever existing.
Even this recent SitePoint article about "Promises" has example code using alert() http://www.sitepoint.com/overview-javascript-promises/I think in part it''s because old habits die hard and part because it's being used during development.That is, it's still a "quick and dirty" way to see what's going on with the code without needing to open up a console.
As far as trying to style alert() for production use I wouldn't bother, there are much nicer alternatives available.
You seem a bit confused about the specs role.
A search for console in the ECMAScript standard also returns nothing. This is not because console is regarded as obsolete or because it has passed its days as a useful tool.
In the ECMASCript specs, in The Global Object section, it says:http://www.ecma-international.org/ecma-262/5.1/#sec-15.1
In addition to the properties defined in this specification the global object may have additional host defined properties.
Both alert and console fit in this category. This is to say that the ECMAScript specs accepts alert or console existence, and, even more importantly, the ECMAScript specs will NEVER decide about alert or console or any of the like, for that matter.
There is no normative committee watching over alert and deciding it's obsolete.
The only one declaring alert dead, for all intents and purposes, is you. This may be true for you, but it doesn't make it so for the rest of the world.
The only thing that changed is the programmer perception. Which should include, for you too, following best practices and NEVER hijack existing properties and object, but instead, create your own, in your own namespace and module.
Given this their use for anything other than debugging or in examples is now impossible as you can't control when these additional checkboxes will be displayed. This means that they are dead as far as using them in live web pages is concerned
As most people want control over how the dialogs they display to their visitors look they cannot use alert() confirm() or prompt() for this purpose anyway as there is no way that the person coding the page can get rid of the checkbox for turning off their JavaScript. Building your own alternatives where you have complete control over how the dialog looks is relatively easy.
Use of these dialogs in debugging scripts or as placeholders in example code is still possible but better alternatives now exist such as using console.log which doesn't leave messy debugging dialogs in your live script if you miss removing one before making the script live.
They may not be totally dead in testing and example code but they are dead in so far as live web pages are concerned - at least they are if you want the code after the alert to run and not have the person visiting your page make use of the checkbox in the alert to turn off JavaScript for the rest of the page.
Personally I prefer not to see left over debugging statements and so have turned them off in my browser. As they can be easily turned off in all modern browsers there's no guarantee that they will be seen at all by your visitors - another reason to not use them.
The OP was asking about how to style their alert calls to look the way they want. The only way to do that is to either replace the call with custom code or to override that method with your own custom one. Given that different browsers display alerts etc differently from other browsers there's no reason in this instance why overriding it to use your own custom appearance is unreasonable. The alert call will still be displaying a dialog - just one that looks how you want it to look rather than the dozens of different ways that it will display normally depending on the browser that is being used. It isn't like all the browsers have the same code in their built in alert function - only by overriding it can you get all the browsers to behave the same way when it is called.
You are a little off here. When the alerts have a high repeating rate, ONLY THEN is the user presented with that option. This is to prevent infinite alert loops which would block the browser.
Yes, you will control the appearance. But replicating the scripts execution stopping the native alert features, that's a thing you yourself have not solved in your replacement you linked to, a few posts up.
No one uses alert to debug these days, or even reasonable distant times, it's a toy tool, it always has been.
No, that's precisely the reason for not hijacking the alert. As any native can be easily hijacked, there's no guarantee that your replacement will take precedence and will be seen at all by your visitors as you intended - another reason not to hijack them.
Hijacking natives also spells out questionable intents from the web site.
And that overriding would make it for a half ass job which would cost any real developer its job. Do it properly, learn to do it properly, or step aside. That's my opinion.
You seem to be going around in circles with this. I'm going to stop here.


text:
PSP Wallpapers | PS3 Wallpapers
This is a Cloud Rolling In wallpaper. This Cloud Rolling In background can be used for your PS3 or other widescreen devices including a computer as long as the resolution matches. You can find several other widescreen wallpapers in our large selection of PS3 wallpapers, possibly including other Cloud Rolling In wallpapers and backgrounds.Short Link for PSP/PS3 Browser: http://www.psxextreme.com/s/1445
| Wheat Up Close Wallpaper | Trees of Ice Wallpaper |
Use this picture on your site or blog!


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
Santa Claus and local fire departments have a very close bond. Many fire departments, such as Zoneton and Shepherdsville, will take Santa Claus around the neighborhoods atop their trucks.
If you currently subscribe or have subscribed in the past to the The Pioneer News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning The Pioneer News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
THE Birdseye Sports Evesham Sunday Football League Division Four promotion race is gathering pace.
Third-placed Ambassador remain title favourites after a 5-2 victory at Harvington with goals from Booth (3), Sears and Reading.
The success moved the Evesham side within five points of the leaders with three games in hand.
Leaders Stratford United suffered a shock 1-0 defeat at Stour Excelsior Reserves, who scored through Grace.
Second-placed Sun Inn recorded a comfortable 6-1 win at Vale Wanderers with goals from Ed Major (3), Parry, Davies and Comfort. Hunter replied.
Pebworth won 5-3 at Bengeworth with Rose (2), Wilkes, Williams and Turner on target, while Jelfs (2) and Mather netted at the other end.
Tewkesbury Town Reserves won 9-4 at Ambi Allsports.
Fairfield moved four points clear at the top of Division Three with a 3-0 win at Elmley Castle. Corr, Cother and McCall scored.
Inkberrow recorded a five-goal win over Anchor Harriers with L Sheen (2), K Sheen, Brant and Johnson.
In Division Two, doubles from Dean Cox and Lee Tustin helped Offenham Rovers overcome Evesham United Harriers 5-2.
Bredon took the local honours 3-2 against Alderton with their goals coming from Twine, Diamond and Gibbs. Charlton grabbed a brace in reply.
While their nearest rivals were involved in cup matches, Pinvin United continue to head Division One.
A strong second-half secured the points against Evesham WMC in a 5-2 victory as Mark Bellamy led the way with a hat-trick alongside goals from Izod and Shepherd. The Workies responded through Ford and Iorns.
Bear recorded a five-goal win over Mickleton Rangers with Staley (2), Smith-Daniel, Davis and Cooke scoring.
Bretforton Old Boys and Eckington moved into the last eight of the Evesham Hospital Junior Cup with 3-2 and 3-0 wins over Redditch United and Broadway United respectively.
Honeybourne Gate Inn moved into the semi-finals with a 5-1 victory at Defford/Besford United.
Tewkesbury Town lost to Kidderminster League side Ocean Designs 5-2.
In the Minor Cup, WMK and AC Olympia progressed with 5-3 and 2-0 wins at Alcester Town and Fortis respectively.
Tesco United lost out 4-1 at Washford Lions and, in a quarter-final tie, Stour Excelsior won 4-2 at Cidermill.


text:
October is a time of changing leaves, Halloween, and cozy sweaters, but it also signifies a time when people come together to raise awareness and support research for finding a cure. Hundreds of beauty companies have released Breast Cancer Awareness Month items this year, including the nail polish industry. Here, see five brands who have gone above and beyond in the lacquer category, and what they have to offer for 2011.
Source: Flickr User Miss a Liss


text:
Jets Maybin, Coples fined for hits on Andrew Luck
Posted by Michael David Smith on October 19, 2012, 5:16 PM EDT
Getty Images
The Jets put a beating on Colts quarterback Andrew Luck on Sunday. In two cases, they put too much of a beating on him.
Jets defensive end Quinton Coples was fined $10,000 for grabbing and twisting Lucks facemask, while outside linebacker Aaron Maybin was fined $7,875 for elbowing Luck after Luck had already been knocked to the ground.
Coples cost himself a sack with his penalty: He took Luck down for a loss of 14 yards, but the 15-yard penalty wiped out the play and gave the Colts a net gain of one yard.
Maybin cost teammate Antonio Cromartie a touchdown with his penalty: Maybins hit on Luck came as Cromartie was returning an interception for a touchdown, and although Cromartie didnt lose the pick because the foul came after the interception, the return was nullified.


text:
Finding Her Future Path
Since becoming a post-bac intern at central Florida's Archbold Biological Station, AU alumna Stevia Morawski '12 has handled eastern indigo snakes during a research project, gone frogging and birding with other interns, and helped with prescribed burns to protect the scrub environment.
The environmental studies program graduate, who has interned at the 8,840-acre research station and reserve since July, works 20 hours a week in the plant ecology lab, tracking such data as the population dynamics of rare and endemic plants. The other half of her time she spends on a personal project.
For that project, Morawski is studying mycorrhizal fungi in scrub ecosystems, relatively delicate ecosystems often threatened by development.
The U.S. Department of Agriculture describes mycorrhizal fungi as mutualists—fungi found on plants' roots, they extract carbon from the plant while helping to make phosphorous soluble and to deliver the plant soil nutrients and, possibly, water.
For Morawski, who came to Archbold to help figure out which direction she wants to pursue as a researcher, the experience has been rewarding.
"I literally googled post-bac ecology research and that was the first thing that came up," she says, describing how she found the Archbold Biological Station. "I wanted to be able to do research with just a bachelor's degree, which is kind of difficult to do. I wanted to help figure out whether I wanted a master's or a PhD and in what field. I thought this would be great exposure, and it has been."
The Archbold Biological Station was established as a not-for-profit research institution dedicated to researching the plants, animals, and environment of the Lake Wales Ridge area. The station has several kinds of habitats and, since its founding in 1941, researchers have identified on the property 21 species of amphibians, 27 fishes (there's a 90-acre lake), 44 mammals, 48 reptiles, 208 birds, and 593 vascular plants.
There are also more than 6,000 kinds of insects and other invertebrates, and it is home to 117 species of ants, the widest-known diversity of ants on a single North American site.
One factor in her winning an internship at the research station, Morawski is certain, is her work at American University. As a student in Professor Kiho Kim's environmental issues seminar, she coauthored a paper with Kim that was recently published in the Journal of Hunger & Environmental Nutrition. The paper gave the first hard evidence that eliminating serving trays from the university's main dining hall substantially reduced food waste and energy use.
That's an extraordinary accomplishment for any student, particularly an undergraduate.
The paper, which has generated a good deal of buzz online, showed that after surveying 360 diners over six days in February through March 2009, removing trays from the dining hall reduced food waste by 32 percent and dish use by 27 percent.
Soon after the class finished its study, AU removed most trays from its main dining hall. The Tenley campus dining hall later followed suit.
"Kiho was my academic mentor," Morawski says. "I think he was trying to give me opportunities to learn how to write a paper that was intended for publication in a journal . . . He wanted me to calculate the carbon footprint of how much energy would be saved by removing the trays from TDR (Terrace Dining Room)."
Those calculations didn't make the final draft, but Morawski was also tasked with examining trends with tray use and the research conducted by schools that had gone trayless.
"I found very few studies, actually, that have a good experimental design," she recalls. "There had been a lot of schools that were going trayless because there were claims out there that it saved food and reduced food waste, but there was not much actual scientific evidence."
So has coming to Archbold brought Morawski any closer to deciding her future direction as a researcher?
Being at Archbold "has confirmed to me that I do want to work in something that involves plant science," Morawski says. "Also, it has proven to me that I can't have an office job. I just hate being inside all day. Working outside has been the best thing that's happened to me. I love my job so much."


text:
Fair warning: If you're looking for Homer's Digest, this post may not be for you. Meanwhile, here are my key thoughts for the post-ASG stretch of the season.
This could also pay homage to another of my infamous thread titles, as This Team Is Built to Play Miami in the Playoffs.
When we drafted Paul George, I was looking forward to the day we could trade one of our two SFs for a shooting guard that can create his own shot off the dribble. Granger's injury now has me looking forward to just seeing how much better we'll be with both of our wings on the court, taking pressure off each other. Paul George has shown tremendous growth. His next challenge is to show that its not just because he's in the role of "best wing on the team" and that he can keep it up with the team at full strength. I think the next step could be challenge for him to as assertive on a team at full strength vs. stepping up on a depleted team. I think he'll get through this challenge, but with growing pains along the way. Probably more growing pains than PD overall is expecting.
I thought Paul George's ASG appearance was impressive, but I think for different reasons than the rest of you. I now know exactly where I want Paul George when Hill and West run a pick and roll at crunch time. I want him on the weakside baseline for (1) spacing and (b) he's deadly there in a catch-and-shoot when the ball is reversed. I still think the play MUST start in Hill's hands as a Hill & West pick and roll is the offensive option in which all five guys are threats to make the last shot and must be played straight up defensively. And I still don't want him in a position where he has to put the ball on the floor.
I'll go one step further, although I think I saw this somewhere else on the web yesterday. Paul George's performance was the best Pacers' performance in an ASG over the past 25 years. While Paul's offense is still primarily as a catch-and-shoot guy, he brought defense and wing rebounding to the second quarter of an NBA all-star game. That's a rare accomplishment.
I'm looking forward to Lance with the second unit, becasue the second unit needs a go-to guy. A little concerned, though, that he'll act like Dhantay Jones with the second unit and hog the ball. He's really cut down on his, "what in the world is he thinking?" kind of mistakes. He's played well within in the team structure. We'll know soon if Lance is better as the fifth option with the starters or as the go-to guy with the bench. Either way, he's made so much progress that we could have two most-improved candidates right now.
Was debating with a Bulls fan over the weekend... he said Miami would walk away with the East this year. I said, "No, they can't beat us." West and Hibbert together mean that Bosh is worthless, and while some of us (okay, maybe just me) may not have ever been believers in Bosh, they don't really have a better alternative. We are a matchup problem for them. Clearly our best hope is to chase down the #1 seed, but is that realistic? I don't know. I know Miami would rather play NYK than us.
Hibbert's contract gets too much attention on here. There are two common and popular fallacies that keep appearing - (a) that there is a statistic that measures the "presence" of a post player and that (ii) compensation of an NBA center is tied to some metric or statistic. I know his FG% has been awful this year, but I can't imagine this team leading the Central Division right now with somebody else playing C, at both ends of the court. I hope over the second half of the year he rediscovers his shooting touch and crushes this silly conversation.
And lastly, what this team really needs is Chuck Person.
And I could use more confidence against a team like the Knicks, because I'm worried that we won't get to take our best shot at Miami if we end up in the 2/3 bracket against New York.
There you go. Fire away.


text:
Topic: Are we on the right track?
I must say that I am so very glad I found this site for my wife. It's been an incredible source of information, communication, and compassion.
I still don't know the terminology well so forgive me if I state something incorrectly. We are in our first phase of treatment for ICC (multiple tumors in liver plus lymph nodes). By phase, I mean we are now in the second of the three chemo (Gem/Cis) cycles prescribed. Each cycle being 2 weeks on and one week off.
Overall, I feel my wife is doing OK with the chemo regimen. She started cycle 2 yesterday and today is doing well. Biggest issues; fatigue and then nausea but both under control.
My question/concern is her abdomen is still very distended. At our meeting last week with our Onc, we asked about it. We did not get any actionable response. Her blood work has shown great improvement in all indicators. Her bilirubin level has dropped to 1.0 (from a high of 5). But she is so very extended and cannot function normally. We don't know if this is all tumor related (she does have large tumors) or something else which could be corrected.
Is this what we should expect at this point or should I be pushing for further tests? I feel like something positive is happening, but it is not reflected in my wife's current quality of life. She is not able to do much, yet feels better now than she did a few weeks ago when pain was the major issue.
Thanks for your assistance.
Carl (and Lynn - my wife)


text:
The Tampa Bay Rays are staying put—both in the Tampa-St. Petersburg area and in Tropicana Field.
With 14 years remaining on the lease agreement between the Rays and Tropicana Field in St. Pete, the Rays are staying put in the dome until 2027.
Rays owner Stuart Sternberg is content with that, knowing that building a new stadium is a long process.
"It's far, but it's not that far because I can't in 2026 snap my fingers and all of a sudden have a place to play," Sternberg told FOX Sports' Jon Paul Morosi. "The groundwork needs to be done, starting very soon. You've got to figure out the proper location, whether it's 10 yards from where we're playing or 30 miles. Then you have to figure out if it's feasible. Then you have to go through the approvals and everything else. Even if you have a location, just to get that OK'd takes years. Then it takes years to actually build the thing. At some point in the next few years, we've got to have it figured out."
MORE: Blue Jays take 11th straight
The Rays are on pace for a sixth consecutive wining season, but they have the lowest average attendance in the American League with 17,909 fans per game.
Sternberg quickly shot down a question about the prospects of his team leaving the area. As part of his response, he made reference to Montreal, which lost the Expos after the 2004 season to Washington, D.C. Sternberg predicted that a major league team would eventually relocate to Quebec, but it wouldn't be his.
"In the next five years, no. In the next 20, yes," Sternberg said. "I thought about it as a great baseball market. But this is probably three, four years ago. I was asked and pressed about it. I said I could think of seven (viable) places (for relocation). But I'm not looking. I just want to explore my back yard."


text:
Try after try fails to help elderly vet with Section 8 problems
BAKERSFIELD, Calif. (KBAK/KBFX) Volunteers are again trying to solve a local veteran's housing problem so he can stay in his apartment. The Korean War vet relies on Section 8 assistance with this rent, but for the second time the stove in the unit may not pass a required inspection.
The plight of 82-year-old Bill Quigley got a lot of attention after Eyewitness News highlighted his problem. He served as an Air Force cook, and he didn't mind that the gas stove in his Bakersfield apartment only had three working burners. But, that didn't pass the inspection for Section 8. And if the unit doesn't pass a re-inspection, Quigley would be forced to move in order to keep his rental assistance.
"I don't know what to do, I cry half the night," Quigley told Eyewitness News at the end of May. That's when viewers started calling with offers of help.
One of those was Chris Stille, he's a supervisor with a major utility. On May 27, Stille came out to the apartment and tried to fix the gas range, but one burner was so badly damaged it could not be repaired. Officials with the Housing Authority of Kern County have told Eyewitness News each appliance must function as designed in order to pass Section 8 inspection.
After the original stove couldn't be fixed, last week the landlord put a replacement stove in Quigley's apartment. But it also had problems. One burner doesn't light up properly.
On Tuesday, Stille again volunteered his personal time and came out to fix that range. He checked it all over, but it also couldn't be repaired. One burner only worked intermittently.
"It comes on sometimes, and other times it's not," Stille explained. Also, with the burners on the left side, the turn-on knob for the front lights up the back burner -- and vice versa. "Something's been crossed over in the way this is operating. I have a feeling that somebody lifted the top, which damages the appliance," he said.
Stille had to tell Quigley this second stove probably won't pass the Section 8 inspection.
The veteran has lived in the small, one-bedroom unit for fourteen years. He doesn't want to move, and doubts he can afford the cost of a deposit and first- and last-month's rent for a different apartment.
But, other offers to provide him with a new stove have come in, and Quigley's ready to consider that. "I'd like to have another stove," the vet said. "If I'm going to fail (the inspection), they may give me another 30 days, but what's the sense in that?" He thinks the landlord doesn't care.
But, volunteers are lining up to help Quigley, and Eyewitness News will contact those folks and also call the Housing Authority again to see what the best course of action will be.
Stille put in over an hour trying to fix the first stove, and was more than happy to try again with the replacement. He has no doubt it's important to help this veteran.
"This man, he did so much for the country," Stille said. "Really it's the least I can do. He's just such a nice man."


text:
Graduate Careers
Our renowned reputation, high admissions standards and alumni network combine to give you a significant edge in the job market.
More than 90 percent of our graduates are routinely placed by graduation. You will join other Mines graduates who are valued innovators and leaders in their fields and continue the school's long tradition of making meaningful contributions to society through discovery, research and application.
Career Services at Mines offers students an abundance of resources: career counseling, tips on resume writing, practice interviews, placement into competitive internships and co-ops, and — of course — full-time placement upon graduation. They can also help you find a part-time job on campus.
Learn more at the Mines Career Center.
If you would like to visit campus please click here: Visit Mines
Learn more about the Admissions Process
Colorado School of Mines
engineering the way
Graduate School
Student Center E140
Golden, Colorado USA 80401-1887
(303) 273-3247
(800) 446-9488 x3247


text:
Library seeks entries for story/poem contest
October 9, 2012
Douglas County Public Library is accepting submissions for a story/poetry writing contest.
Sixth- through 12th-graders may submit a story or poem about their best Halloween experience. Stories must be between 500 and 2,500 words and must be submitted by Oct. 13. Entries may be emailed to firstname.lastname@example.com. or delivered to the library at 233 Warrior Way in Zephyr Cove, Nev., or the branch at 1625 Library Lane in Minden, Nev.
The winner will be announced during Teen Read Week, the week of Oct. 15, and will receive a Halloween pumpkin filled with candy.
The Teen Read Week writing contest is sponsored by the Friends of Douglas County Public Library. Some entries may be posted online.


text:
I am thrilled with all the new enhancements in Ableton Live 8. Two other NAMM 2009 announcements having me scratching my head a bit though. Max for Live and Motu Volta are two new products that have a large buzz around them in the blogo-twittersphere. Max for Live is an extended version of Ableton that will allow you to create your own instruments and effects. It uses a flow diagram, object and element metaphor as it's interface. Motu Volta is software that turns MOTU and RME audio interfaces into highly editable CV (control voltage) interface.
The question I keep asking myself is, "Will these new tools help me make better songs?". Since I already own Ableton Live, a Motu interface and several vintage analog synths with CV there is no doubt my curiosity will lead me to my credit card.
Volta First Look from Matthew Davidson on Vimeo.
What excites me about Max for Live more than programming my own devices will be the devices other people come up with. I own a Kenton Pro-2000 CV to MIDI interface but because digital audio recording is so easy these day I rarely use it. I just record my old synths as audio and manipulate them after the fact. As much as Volta intrigues me I fear it may put an unnecessary software layer between my hands and hardware knobs.
I know Max and Volta are completely different beasts but I think you get my point here right? I guess there is a time for right brain knob twisting and song writing and a time for left brain analytical sound design.
What do you think?


text:
Implemented a system for sending product brochures to customers of a mattress manufacturer on an immediate basis after they show interest in the product.
Jessica G., Intelligent Assistant
Las Vegas, NV
Manage the entire front-end of a prominent regional shuttle company client including answering questions, providing route information, scheduling reservations.
Cathi L., Intelligent Assistant
Cherry Creek, CO
Identified a gap in customer services for a retail client and proactively created a solution to allow them to better serve their clients needs.
Anne J., Intelligent Assistant
Red Bank, NJ
Deposited important cheques to a bank in Toronto for a client while they were working remotely in the Bahamas.
Jessica D., Intelligent Assistant
Toronto, HBC
Manage all customer service for an Industrial Gas Detection Appliance Distributor including updating clients on orders & order status, tracking information, and more.
Ashley J., Intelligent Assistant
Schaumburg, IL
Contacted several people on behalf of our Financial Planner client to invite them to a special seminar. This saved our client time and helped them to gain more business.
Kimberly M., Intelligent Assistant
El Paso, TX
A client's presentation materials hadn't yet arrived 1 hour before an important meeting. We printed, made copies and put together packets of replacement materials.
Kitshara W., Intelligent Assistant
Alexandria, VA
Organized and managed a Job Fair for a new business. Greeted potential hires and handed out applications on our client's behalf.
Kelsey C., Intelligent Assistant
South Surrey BC
Helped a client capture several new sales for their new heart device by answering all callers questions accurately and connecting them with a salesperson during the call.
Elizabeth S., Intelligent Assistant
San Diego, CA
Hired a demolition crew to destroy and remove a building for a Real Estate Investor and coordinated all the related contracts and fee payments.
Laura M., Intelligent Assistant
Denver Lodo, CO
Your business is ready to take off. All you need is a launch pad that is more professional than the corner coffee shop. So consider a traditional full-time office, shared, or part-time, flexible office and staff without the overhead. You'll have a private, fully furnished office with phones, internet service, conference rooms and a locked mail box. Our receptionist is your receptionist -always ready to handle your calls, schedule your appointments, and almost anything else you need. No more missed important calls, amateurish cell phone answering or business calls going straight to voicemail. And it all comes with a professional address worthy of your vision. There's no stopping you now.
Image is critical in your business. So even though you still work out of your home office, your ambitions are bigger. You need an address to match. Something professional, prestigious. A place where you can meet with clients, receive packages and have someone answer the phone who doesn't refer to you as Dad or Mom. Your hours are your own, so you'll want secure access that lets you come and go as you please 24 hours a day. And mail forwarding when you don't feel like going in to your office. All at a price that remembers you're a freelancer, even if you are an ambitious one.
You don't wait for clients to come to you - you go get them. You're out there, solving their problems every day. Paying for an office you're rarely in doesn't make sense. But it sure would be nice to have access to a fully furnished and equipped executive office when you need one and wherever you go. Especially when you need to make a presentation. And that's what we give you - a private office in every one of our North American locations. You get 24 hour access with all the amenities. Executive furnishing, phone and internet service, white boards and flat screens, conference rooms and even a kitchen. All available on an ala carte hourly, daily or weekly basis. Whatever fits your changing schedule and business needs.
Your docket is always full. So you rarely have time to sit in an office. Your clients only call when they need you, and that could happen at any time. You could be in your car, at home or in a place where a phone is off limits. Voice mail isn't going to help your prospects and clients. They want a real person to answer the phone - and a highly trained, professional one at that. Our receptionists answer, screen and transfer your calls to any number you want. Our Intelligent Assistants can do intakes, confirm meetings and schedule your appointments. All from an office that looks incredibly buttoned up, on those occasions when you actually need one.


text:
COUPLES looking to tie the knot could be in luck this weekend when a free wedding will be up for grabs at Priory Hall's open day.
Dudley Council is offering one betrothed couple the chance to win a wedding, worth £320, at the popular venue through a free prize draw.
To win, couples must pop their names in a box at the event, which will be held at the grade II listed registration office tomorrow (Saturday) from 10am to 4pm.
Dudley Mayor, Councillor Alan Finch, will reveal the winners at 3pm.
If the winning couple has already booked their big day at the venue, the fee will be waived.
Those that haven't booked will receive the free wedding.
The winning couple will only be required to pay the statutory notice fee of £35 each.
Councillor Gaye Partridge, cabinet member for human resources, law and governance, said: "Our wedding open day attracts couples from across the borough eager to visit our beautiful Priory Hall venue, pick up tips and get inspiration for their big day."
Information on ceremony cars, wedding cakes, balloons, photographers, bridal wear, suit hire, flowers and much more will be on offer from the various exhibitors at the event.
Bargain hunters can also purchase once-worn designer and off-the-peg bride, bridesmaid, mother of the bride and page boy clothes.
For more information, call 01384 815373.


text:
Appetite during Treatment
Do you have any tips for helping my husband improve his appetite while on treatment?
Tracy Lautenbach MSW, LCSW, Oncology Social Worker at Penn Medicine, responds:
To promote appetite it is important to create and follow a meal schedule with small, frequent meals/snacks every 2-3 hours. Treat your food like medicine and do not skip meals as you would not skip your medicine; to help get in the meals, have easy to grab foods available. High calorie beverages such as Ensure, Boost, Carnation Instant Breakfast, chocolate milk, and milkshakes can provide additional calories. Appetite and oral intake can be improved by good side effect management so it is important to discuss your side effects with your care team so that the management can be adequate. Also, if your appetite removes poor for a prolonged period it is important to discuss with care team for consideration of appetite stimulant medication.
This question and answer was part of the OncoLink Brown Bag Chat Series. View the entire Head and Neck Cancer Q&A Webchat transcript.


text:
We're Sorry... The page you are looking for cannot be found or is no longer available.
Please click here to go to the home page, or wait as you are automatically redirected.
To learn more about us and the areas we service, please click here, or feel free to contact us. Our customer service Help Desk would be happy to answer any questions that you might have.


text:
Drew Patterson '06 has spent his fast-paced entrepreneurial career on the move. The 37-year-old travel industry veteran was part of the founding team of Kayak, a metasearch leader for flights and hotels in the United States that was bought by Priceline in 2013 for $1.8 billion, and cofounder of the luxury travel flash sales site Jetsetter before he founded Checkmate, an app that allows travelers to check into hotels on their smartphones. Last year Patterson became CEO of Room 77, a hotel search site launched in 2011. The startup, which he joined following its acquisition of Checkmate, has already raised more than $40 million from industry giants like Expedia and Concur that support early-stage innovators in the field. Patterson recently talked with about what it takes to launch, grow, and lead successful startups — and why Wyoming is his favorite vacation spot in the world.
You've worked at tech travel startups since they came on the scene. What attracted you to this niche area?
After college I followed a friend to Starwood Hotels and Resorts amidst the 1999–2000 Internet bubble. At the time, there was lots of interest in how technology was going to change travel and hotels, including selling hotel rooms online. While there, I got to know Steve Hafner, who cofounded Orbitz. He reached out with a plan for a travel search engine and asked me to be part of the team. I thought he was a smart guy with a good idea. That's what led me to Kayak, which was an amazing journey. It was an incredibly dynamic, talented group of people. In our own limited domain, we changed the world and brought something new to the market.
After five years at Kayak, I got to know the investors behind Gilt Groupe. We started talking about flash sales and Gilt's impact on fashion. This was in the midst of the recession, so hotels needed help generating demand. Also, it seemed clear that travel sites needed some personality. Travel e-mails and merchandising were functional but bland lists of deals and prices. I believe travel can be an emotional category — and a travel service should reflect that. That was the genesis of Jetsetter.
How is your newest company, Room 77, different from other hotel metasearch sites?
Room 77's hotel search engine stands out by being more comprehensive and more relevant than other search sites. We include more sources of data — for example, we're the only site to include prices directly from tens of thousands of hotels — and, as a result, we find lower prices.
Also, we start with the perspective that the hotel search problem has not been solved. Selecting a hotel is a subjective and personal decision. It's challenging to identify what the right place is for any given trip. Search engines need to have more intelligence to answer this question. At Room 77, we anticipate what the traveler seeks and ask questions that let us make the right recommendation. If you search for New York City hotels on Room 77, for example, we'll ask whether you want to stay near Lincoln Center or other geographic points of interest, or if there are certain types of hotels you're looking for.
Then we have the Checkmate product, which allows travelers to check into a hotel through their phone in advance of their arrival. So, like with an airline, you can complete the check-in process and start a dialogue with the hotel before you arrive. Our users know what time their rooms will be ready before they leave home, and when they arrive, there is a separate line that enables them to skip the wait at the front desk. Hotels also get better information about their guests' needs and are able to merchandise room upgrades and other services.
It feels like the time is right for this kind of experience at a hotel. Already, thousands of hotel guests every day are using our service, and we are getting great reviews from both travelers and hotels.
What's your advice for entrepreneurs launching companies and for those who are joining startups?
Go out and do it. You can spend a lot of time debating strategy and how you might go to market. Momentum solves a lot of problems, so find ways to generate and sustain progress. Your initial product will not be everything you want to bring to market; it may not even be your long-term business model. But if you can generate a positive trajectory, you can start to get buy-in and support, and that makes other opportunities possible. To get a venture off the ground, you really just have to start.
What did you learn at Kayak and Jetsetter that helped prepare you for your current role?
Ultimately the consumer is right. The consumer always wins. If you can come up with ways to create real passion, real delight on the part of the consumer, things will work out. Paul English, the other cofounder of Kayak, is a really thoughtful, visionary guy. He would always say that it's not enough that consumers come away from the Kayak experience saying, 'oh, that was great.' It's got to be like, 'oh, that was so fucking awesome. I'm going to go out and tell 10 of my friends right now.' That's the level that you have to be playing for.
If you can make that happen, good things will come. When your product experience makes a consumer's life better in a real way, then your marketing takes care of itself. Strategic relationships, partnerships, all those things will start to take care of themselves if you solve a consumer problem in a very profound way. But that's a very difficult task.
What's most important to keep in mind when pitching an idea to an investor?
The most important requirement is that you and your investors are aligned: that your goals and their goals are in sync. Inevitably, at some point, the business will face challenges; that's the nature of starting a venture. What's important is not the exciting moment when you cash a funding check but rather when you just lost an account — and now what? An entrepreneur needs to feel like his investor is a partner. Investor/entrepreneur alignment means having a common understanding of the timeline and risks associated with the project. For example, if an investor is late in their fund cycle, there may be pressure to reap profits and sell so the fund can improve its return. You don't want a situation like that to force an outcome in the business.
What's the downside to being an entrepreneur?
It's clearly stressful. Things may work out; they may not. It's a roller coaster. The highs are higher, but the lows are lower. Managing your own emotional balance, especially when you are emotionally connected to the business, is a challenge.
But one of the payoffs is that when you work from a small base, small changes feel really significant. At first no one knows who you are. Then it feels really good when one person knows about you. The sixth person feels even better. You have the sense of watching an idea come to life.
Bringing something new to market is always threatening and disruptive to the status quo. It always gets resisted at the onset. What's exciting is to go through that phase of reticence, then acknowledgment and acquiescence, then being embraced—where the market goes from, "this is a stupid idea, it'll never work," to at least, "well, we'll look into it," to "oh, yes, that seemed like the right idea all along. We were behind it from the beginning." To be a change agent is quite satisfying.
How did your background at Columbia prepare you to launch and grow companies?
Columbia helped formalize skills, frameworks, and thought processes that I didn't appreciate or have before. I took a number of classes around entrepreneurship and finance in the MBA program. I was working at Kayak when I was at Columbia. It was valuable to do a bunch of stuff during the day that was very practical, very hands-on in a real business, and then have the time to be in a more academic setting and step back to think about the structure and framework to put it all together. I felt like it was a great connection between what went on in the classroom and what would happen in the marketplace.
What's a favorite place you've traveled?
I had a great trip with some friends to the World Cup in Germany. I also took a trip once to Brazil and Argentina. But my favorite place is Jackson Hole, WY. That's where my wife and I got married. It's spectacular. The views and mountains are incredible. The people are great — completely unpretentious; everyone's really friendly.
Do you have any tips for travelers?
I think the best travel experiences are where you're able to connect with locals in some way and have a real sense of flavor. If you have some connection to the people in the place you're going, it always makes a difference. My wife and I typically travel with friends and try to take friends' recommendations and advice. After college, I went backpacking through Europe for three months and visited friends who were working in a number of different cities there. Just spending a couple days with someone who actually lives there makes it such a different experience.


text:
Belinostat in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Adult Primary Hepatocellular Carcinoma Advanced Adult Primary Liver Cancer Localized Unresectable Adult Primary Liver Cancer Recurrent Adult Primary Liver Cancer
|Drug: belinostat
|Phase 1 Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase I/II Study of PXD101 in Patients With Unresectable Hepatocellular Carcinoma With Pharmacokinetic and Pharmacodynamic Evaluation
- Dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of belinostat in patients with inoperable HCC (Phase I) [ Time Frame: Course 1 ]DLT is defined as any grade 4 hematological toxicity and any grade 3 or 4 non hematological toxicity during cycle 1, excluding alopecia. Specifically, grade 3 nausea, vomiting, or diarrhea that does not respond to therapy is considered dose-limiting. Also, delays in treatment greater than 2 weeks are also dose-limiting. MTD is defined as the dose below which >= 2 of 3 or >= 2 of 6 patients experience DLT. Graded using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0.
- Tumor response in patients with inoperable HCC using belinostat (Phase II) [ Time Frame: Every 2 courses (approximately 6 weeks) ]Evaluated in this study using the new international criteria proposed by the Response Evaluation Criteria in Solid Tumors (RECIST) Committee. The 95% confidence intervals should be provided.
|Study Start Date:
|May 2006
|Primary Completion Date:
|August 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment (enzyme inhibitor therapy)
Patients receive belinostat IV over 30 minutes on days 1-5. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity.
Drug: belinostat
Given IV
Other Name: PXD101
Detailed Description:
I. Determine the dose-limiting toxicity (DLT) and establish the maximum tolerated dose (MTD) of PXD101 (belinostat) in patients with unresectable hepatocellular carcinoma (HCC). (Phase I) II. Assess the pharmacokinetic profiles of PXD101 in these patients. (Phase I) III. Assess tumor response in patients treated with this drug. (Phase II)
OUTLINE: This is a multicenter, dose-escalation phase I study followed by a phase II study.
PHASE I: Patients receive belinostat intravenously (IV) over 30 minutes on days 1-5. Courses repeat every 3 weeks in the absence of disease progression or unacceptable toxicity. Cohorts of 3-6 patients receive escalating doses of belinostat until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
PHASE II: Patients receive belinostat (as in phase I) at the MTD determined in phase I.
After completion of study therapy, patients are followed for up to 8 weeks.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Histologically or cytologically confirmed hepatocellular carcinoma that is not amenable to curative resection
- Measurable disease, defined as ≥ 1 lesion that can be accurately measured in ≥ 1 dimension (longest diameter to be recorded) as ≥ 20 mm with conventional techniques OR as ≥ 10 mm with MRI or spiral CT scan
- No known brain metastases
- No clinical ascites or encephalopathy
- Life expectancy > 12 weeks
- ECOG performance status (PS) 0-2 or Karnofsky PS 60-100%
- WBC ≥ 3,000/mm³
- Absolute neutrophil count ≥ 1,500/mm³
- Platelet count ≥ 100,000/mm³
- Bilirubin ≤ 1.7 mg/dL
- Albumin ≥ 2.8 mg/dL
- ALT ≤ 5.0 times upper limit of normal (ULN)
- Alkaline phosphatase ≤ 6 times ULN
- Prothrombin time ≤ 4 sec above ULN
- Creatinine ≤ 1.6 mg/dL
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients use effective contraception
- No Child's-Pugh's grading Class C hepatic impairment
- No history of allergic reaction attributed to compounds of similar chemical or biologic composition to PXD101
No marked baseline prolongation of QT/QTc interval, including the following:
- Repeated demonstration of a QTc interval > 500 msec
- Long QT Syndrome
- No ongoing or active infection
No significant cardiovascular disease, including any of the following:
- Unstable angina pectoris
- Uncontrolled hypertension
- Congestive heart failure related to primary cardiac disease
- Condition requiring anti-arrhythmic therapy
- Ischemic or severe valvular heart disease
- Myocardial infarction within the past 6 months
- No psychiatric illness or social situation that would preclude study compliance
- No other uncontrolled illness
- More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C) and recovered
- More than 4 weeks since prior radiotherapy and recovered
- At least 2 weeks since prior valproic acid
- No concurrent combination antiretroviral therapy for HIV-positive patients
- No concurrent participation in another investigational study
- No other concurrent investigational agents
- No other concurrent anticancer therapy
No concurrent use of any of the following:
- Disopyramide
- Dofetilide
- Ibutilide
- Procainamide
- Quinidine
- Sotalol
- Bepridil
- Amiodarone
- Arsenic trioxide
- Cisapride
- Calcium channel blockers (e.g., lidoflazine)
- Clarithromycin
- Erythromycin
- Halofantrine
- Pentamidine
- Sparfloxacin
- Domperidone
- Droperidol
- Chlorpromazine
- Haloperidol
- Mesoridazine
- Thioridazine
- Pimozide
- Methadone
Please refer to this study by its ClinicalTrials.gov identifier: NCT00321594
|United States, Wisconsin
|University of Wisconsin Hospital and Clinics
|Madison, Wisconsin, United States, 53792
|Cancer Therapeutics Research Group
|Singapore, Singapore, 119074
|Principal Investigator:
|Winnie Yeo
|Chinese University of Hong Kong-Prince of Wales Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00321594 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
N01CM62205 ( U.S. NIH Grant/Contract )
CDR0000463519 ( Registry Identifier: PDQ (Physician Data Query) )
|Study First Received:
|May 2, 2006
|Last Updated:
|January 30, 2013
Additional relevant MeSH terms:
Liver Neoplasms
Carcinoma, Hepatocellular
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Liver Diseases
Antineoplastic Agents
Histone Deacetylase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017