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Newent Community School has a new Principal, but she is no stranger at the school.
Mrs Kirsten Harrison has been appointed, with immediate effect, after leading the school out of special measures as its headteacher .
Mrs Harrison took the school out of "Special Measures" within a year, - with the school once more being judged by Ofsted as "Good" in all Ofsted areas, by January 2014.
Following the Ofsted judgement, the governors undertook a national recruitment campaign to appoint the best person to continue taking the school forward.
Mrs Harrison was successful against strong competition from other current Headteachers and Deputy Headteachers for the permanent appointment as the best person to lead the School from "Good" to "Outstanding".
The Ofsted report praised the Headteacher, Kirsten Harrison, as "instrumental" in the school's rapid improvement, citing her "attention to detail and determination that nothing but the best is acceptable for the students in the school" as key to improving the quality of teaching and achievement at the school.
The new Principal recruitment consisted of a rigorous two day selection process which involved interviews with students, staff and governors, lesson observations, data analysis and a presentation.
On her appointment Mrs Harrison said that she was "delighted to be given the opportunity to lead the school into the future ".
"It is a privilege to continue working with such a dedicated staff and such an excellent group of young people," she said.


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subset: commoncrawl


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WITTON Albion supporters will attempt this weekend to break a record set two years ago by World Cup-winning goalkeeper Iker Casillas.
Succeed or fail, they also plan to make a charity donation at the same time.
Organiser Mark Robinson has challenged fellow fans to attempt to beat a benchmark set by Real Madrid's number one for the most goals punted into the net from a pitch's halfway line during 60 seconds.
The Spain shot-stopper managed 11 when he tried in Beijing, China, back in July 2011.
"We wanted to do something we could tailor to a charity event," said Robinson.
"The club has been working hard to interact better with the community around it, so this seemed like a logical progression and something we hope generates a bit of interest.
"Attempting to break a world record wasn't a determining factor, rather it was something we spotted when having a look at the Guinness World Records website.
"This seemed like something we could have fun with."
The challenge, set for tomorrow, Saturday, when Witton host Whitby Town in the Evo-Stik Northern Premier League, is open to anybody.
Robinson has four Albion fans signed up already.
Each person pays £5 to take part, committing also to raising a minimum of £30 in sponsorship for this year's Sports Relief.
The club is offering a signed shirt as an incentive to better Casillas' attempt.
Barclays have agreed to match the sum raised for charity to double the final total.
The challenge coincides with the latest edition of the club's popular Families for a Fiver offer.
Up to two adults, accompanied by an unlimited number of children under the age of 15, can watch the hosts' Premier Division encounter, which kicks off at 3pm.
Witton's under 11s, confirmed last month as champions in the Mid Cheshire Youth League's Division Two after avoiding defeat in 11 matches, will be guests of the club for the afternoon.


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The Royal Ramble: Top Ten Wrestlers To Never Win The WWE Championship!
by, 10-28-2012 at 09:16 PM (10463 Views)
FOLLOW ME @The_RoyalRamble on TWITTER! Awesome announcement coming on my next blog!
In the world of the WWE, you can accomplish many things. For some, getting a spot on the show is an accomplishment. But, you're main accomplishment in the WWE should be winning the big one and that's the WWE or World Heavyweight Championship. In this day and age in the WWE, the people that deserve the title have a better chance of winning than years ago. There are numerous wrestlers that should have won the title at least once, these are my top ten. I will put the name of the wrestler and put the year that should have won next to them. Some may agree with the list and of course, some won't. If you guys want, in the comment box, put your top ten list. Let's start the Ramble!
10. Goldust - 1996
If Goldust was to ever win the WWE Championship in the year 1996 would have been that year. The bizarre one was on top of his game in this year and was one of the top heels of the company at that time. In this year, he won the Intercontinental title, defended it against several of top stars at the time, and had a great feud with Roddy Piper leading up to WrestleMania 12. As his push was looking to get bigger, it remained at the same spot. He remained as top mid-card heel for several years but never got the main event push that he deserved.
9. Rick Rude - 1990
Rick Rude was one these guys that you love to hate. He was so brash and arrogant, but he had the talent to back it up. At SummerSlam 1990, Rude wrestled the Ultimate Warrior in a Steel Cage match for the WWE Championship. In my eyes, Rude should have won the match and title. His contract was up just two months later and that maybe one of the factors to why he didn't win.
8. Razor Ramon - 1992/1996
Razor Ramon was becoming one of the biggest stars that the WWE had in the early 90s. He was a multiple time IC champion and had one of the greatest WrestleMania matches of all time! He showed that he can be a heel or a face and no matter which one he was, he was very good in doing it! The first time he could have won was when he was a heel in 1992 when he was in a feud with Bret Hart and the second was when he was gaining more popularity as a face in 1996. Razor probably would have became the champion if he didn't get suspended for drug use in 1996. After his suspension he really never got back to where was and ultimately ended in him joining WCW.
7. British Bulldog - 1992
Davey Boy Smith, the British Bulldog looked to be the next big thing in the WWE after his classic of a match with Bret Hart at SummerSlam in 1992. As he continued to get pushed, at the end of the year he was caught getting a steroid from England which ultimately ended his run in WWE for the time being and killed any chance of him winning the big one!
6. Paul Orndorff - 1987
"Mr. Wonderful" Paul Orndorff showed that he could be a great champion for the company as a heel. He was in the main event of the first WrestleMania and was one of the best rivals to Hulk Hogan in the late 80s. But it was in 1987 when Orndorff should have became the WWE Champion. He feuded with Hogan for about half of a year and one was one of the most popular feuds for the Hulkster. In that half of a year, Orndorff should have if not once but twice! Orndorff seriously injured his arm during a weightlifting incident and after the feud with Hogan, he wasn't around for that much longer and semi-retired in 1988.
5. Dusty Rhodes - 1990
Dusty Rhodes is one of the greatest stars of all time but to never see him hold the WWE Championship is just sad. He wasn't in the WWE for long but when he was he was the polka-dotted "common man." Some felt this as an insult to him but Rhodes made the best of it and become a huge fan favorite and had a great rivalry with the "Macho Man" Randy Savage. He could have used for title picture in 1990 but never was. In January 1991, he worked the Royal Rumble and then left the WWE and ended his full-time wrestling career.
4. Billy Gunn - 1999
He was an ass man, no doubt about that. Bad Ass Billy Gunn deserved a way better WWE run than he got. He was apart of one of the best tag-teams the WWE has ever seen, the New Age Outlaws. In 1999 the duo split and it looked like the WWE was going to give the run Billy Gunn deserved. Gunn won the King of the Ring and had several big matches that looked as if he was on his way to the top. But his push came to a halt and was put back together with Road Dogg. After this happened, his career never really got back to the momentum he had built up in the year of 1999. He proved in his matches, that he could have been considered a great. He had great mic skills and ring ability. Today in the WWE, I think he could be used very well if he considered taking one more run and shot at it. Maybe team him with Ziggler or feud with him. Billy Gunn will always go down in my eyes one of the most underrated talents of all time.
3. Owen Hart - 1994
In the year 1994, Owen and Bret Hart had one of the greatest rivalries of all time and at SummerSlam 1994 the two wrestled for the title in a Steel Cage. Owen should have really went over in this match. If he would have won, we could have gotten to see him wrestle Bret a few more times. Every time these two got in the ring together it was magic! Owen deserved the title almost more than anyone else in the company. After this year was over, Owen pretty much stayed in as a mid-carder for the rest of his career and never really got back into the main event scene like in 1994.
2. Mr. Perfect - 1992/1993
Mr. Perfect returned to the ring in 1992 as a face for the first time in his career and immediately became a fan favorite. He was getting a very big push and had several big feuds with Ric Flair, Lex Luger, and Shawn Michaels. When he looked to be continued to be pushed he retired due to back injuries. He would return to the ring years later but never got back to the main event scene.
1. Rowdy Roddy Piper - 1985/1986
If there was anyone who deserved to be the champion more, it would be Roddy Piper! The Hot Rod was biggest heel for a few years and in my eyes if it wasn't for him, WrestleMania would have never been so successful! Everyone watched it because they wanted to see Piper get his ass kicked by Hogan! If there wasn't that rivalry, who knows where the WWE would be today. Piper deserved to win the title from Hogan but never did. He remained one of the most popular wrestlers of all time but was still never given the chance to hold the gold!
Thank you for reading, I hope you all enjoyed it. Any ideas for next blog? Send it to me on TWITTER (@The_RoyalRamble) or in the comment box. Thank you guys! On my next blog I will announce my awesome announcement....It's been a long time coming!


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Posted 6 years ago
(1 item)
I can't tell for sure weather it says 1969 or 1989. I found this from a tenet that left it in my apartment, after they ran off with three months rent they owed me. If it's worth something it would be great, at least I would get something from it. Any help would be great THANKS!!!!


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Here is a guest post from Jeremy Cook.
Why not check these out?
- Dual boot Windows 8 and Ubuntu
- The Linux Reviews page
- The Raspberry PI page
- Hey Raspberry Pi, where is my cat?
- How to buy a laptop with Linux already on it
- Get Linux on DVD
Click here to buy the eBook "From Windows To Ubuntu"


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What are some activities a beginner could do to learn horse riding is a sport? I have a friend who doubts that horse riding is hard work. I have a pony she could ride safely and she is also not too tall or heavy. She has never been on a horse which would explain a lot of her statements. On a side note, she will definitely wear a helmet. Also, the pony is only trained to be ridden in English if that affects anyone's plans.
easy dinner ideas ~ diabetic recipes ~ healthy easy recipes


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Case, Keeper...These brain teasers rely on your ability to recognize groups of common attributes. For each of these puzzles you'll need to figure out why the words or letters are grouped as they are. Sometimes you will be asked to pick the odd-one-out or to place a new word into the correct group.
The following words have a similar characteristic. Can you tell me what that is, apart from the fact that they are all nouns?
1. Case
2. Keeper
3. Maker
4. Plate
5. Seller
6. Mark
7. Store
AnswerBy adding the noun "book" in front of them you form a new noun.
1. Bookcase
2. Bookkeeper
3. Bookmaker
4. Bookplate
5. Bookseller
6. Bookmark
7. Bookstore
What Next?
See another brain teaser just like this one...
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A BURNLEY high school has scooped a prestigious award for being a bully-free zone.
Students at Sir John Thursby Community College have achieved the Lancashire Anti-Bullying Charter, and also been named as a Unicef 'Rights Respecting School'.
The school is thought to be just one of a handful in the North West to have achieved the global accolade from Unicef.
To gain both local and global recognition, students wrote an anti-bullying charter, which is displayed around school. An email address has also been set up to help any student having problems. A video for parents, and carers, has also been developed for the school website.
The school then carried out a survery of Year 9 pupils who said there was no bullying among them, or their friends. They also said if anything happened, they were confident about who they should go to, and that it would be resolved.
Assistant headteacher Helen Campbell, who organised the scheme, said they wanted to show how friendly their school was.
She said: "We are a school where everyone gets on well together, and we wanted to show that.
"We've never have had an issue with bullying, but that's no reason to not work hard to make sure all our children are safe.
"We are proud of the way students of all nationalities, disabilities, and abilities, of any race, colour and creed work together."
Headteacher David Burton said: "We are delighted that our students' great attitudes have been recognised. In March, Ofsted told us our behaviour is good and students feel safe, students show a positive attitude to their lessons, and disruptions are rare.
"Ofsted also said our students are polite and respectful to adults, so we want to keep raising standards so every student becomes a great citizen."


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U.S. Energy Stocks Stumble
Shares of U.S. oil and gas producers corrected on Tuesday.
Shares of the Select Sector SPDR ETF (XLE) fell 2%.
Energy stocks have rallied along with the price of oil on fear about violence in Iraq. But Tuesdays moves may have had more to do with profit taking and less to do with fundamentals. Energy commodity prices were a mixed bag Tuesday, with the biggest move in natural gas futures: they jumped 8 cents, or nearly 2%, to $4.84 per million British thermal units.
The price for U.S. benchmark West Texas Intermediate oil was down slightly to $106 per barrel Tuesday, while futures on international Brent prices rose slightly to $114.42.
Fears about Iraq oil output may be easing with Iraq's southern ports producing despite insurgent fighting, though output from Iraq's largest refinery may be slowing, writes energy analyst Phil Flynn. Traders have also been focused on Russia's use of force in Ukraine; a cease-fire would bring hope of more long-term natural gas contracts with Europe.
Among significant moves in energy stocks, the biggest decliner was Pioneer Natural Resources (PXD), down nearly 5%, followed by Nabors Industries (NBR). Down more than 3%: Halliburton (HAL), Chesapeake Energy (CHK), Anadarko Petroleum (APC), Baker Hughes (BHI), Diamond Offshore (DO) and Occidental Petroleum (OXY).
Cabot Oil & Gas (COG) fell 3.5%. Morgan Stanley downgraded the stock to Equal Weight and lowered its price target to $38. Analysts Drew Venker, Evan Calio and Benedict Amoo write:
"We see significant upside by 2016 as infrastructure issues are resolved. However, due to the uncertainty of Cabot's gas differentials and growth outlook near term, we believe investors will remain on the sidelines until major infrastructure expansions are just over the horizon (slated for fourth quarter 2015 startup). We are downgrading to Equal-weight and lowering our price target to reflect wider gas differentials long term, in line with the bearish scenario we expect to be priced in."


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jason_kraft Bakemark in OH, the closest distributor called and "Jeff" their rep was going to email me details and an application-that was six weeks ago. I called him back a month ago and the phone is no longer in service and their website/fax is not working.
I just checked the phone number for the Cincinnati BakeMark, (513) 870-0880, and it seems to be working. It's possible the rep you were talking to left the company (or was fired for not getting back to potential customers).
FYI, I did not need to establish an account or fill out any applications at my local BakeMark since I was picking up the item and paying cash.
Wedding cake bakers are not their target market. Their market is the mom who wants to make a cake or cupcakes for her family.
They adjusted their size because they had no choice. It was the right move for their company. They still want that market of the casual family baker and in order for her to put that box mix in her cart, the price needed to be competitive and stay affordable.
With rising food prices, comanies have balanced raising prices with lower volume. This is not going to change.
Look my problem is that the cake is not baking properly, I understand who their target is but I promise you if a "regular" mom buys this new mix and takes it home thinking she is going to make some cupcakes for her kids, she too will be standing the kitchen crying at the mess! The difference is she is going to think she did something wrong or think she can't even make a simple box of cupcakes for her family. ave no problem with the smaller size I have a problem with the fact that it is not baking properly! They need to go back to the drawing board on this one!
throwingsugar, these sizes have been out for awhile now. I have seen the threads for months. Others are not reporting failed cakes. They are sharing new recipes and amounts for the doctored cakes that they use in their business or hobby.
When I post, I do not address one post unless I single it out like above. My post was an observation on the economics of the time and the company's choice in changes that were a necessity.
The Pillsbury switch is brand new. So new that most stores in my area still have stock of the old sizes. While the Betty Crocker reformulation did not seem to affect quality, the Pillsbury reformulation certainly has.
Has anyone ever tried the cake mix from Country Kitchen? They have white, yellow and chocolate 18 oz cake mixes. I used to live near their store, but now I have to order online from them and don't want to place an order just for cake mix.
In response to a letter I sent regarding the newly reformulated cake mixes that were introduced in July, the Smuckers® company, owners of Pillsbury®, has responded and invited me to meet with their marketing and research and development teams in October. While the company knew that many bakeries buy their wholesale bulk cake mix for volume production work, they were surprised to learn that so many small home businesses and bakeries used the 18.25 oz. boxed cake mixes for their cakes. They assumed that grocery store sales reflected household consumers, and the outpouring of unhappy responses they received from business owners regarding the new product was unexpected. In an effort to give them a more accurate picture of how we use cake mixes in our cake decorating businesses, Id appreciate your feedback in the following questionnaire if youd like to participate. Feel free to sign your name or reply anonymously, and thanks so much for your response!
Sincerely, Dianne Rockwell
I've invited you to fill out the form Cake Mix Survey. To fill it out, visit:
Now, if someone could get Duncan Hines to be concerned about their inferior, reformulated mix I would be a happy baker. They seem to be clueless!
Thanks for your help.
As mentioned in another thread, cake mixes marketed at professional customers are another option. For example, you can be sure that the size and formulation of Pillsbury's Gold Medal 5# cake mixes will never change since so many professional bakeries rely on them.
Where can you buy Pillsbury Gold Medal 5# cake mixes?
AThe last two cakes I baked using Pillsabury cake mix were so flat I was embarrassed to serve them. I'm not a novice, I've been baking cakes using their mixes for 55 years and this is the first time I've ever had a problem. Believe me, the moms and grandmas out here are just as proud of the cakes they make as a professional baker. We are the professional bakers for our families. What's more important than that? How do I remedy this 'flat cake' situation?
You can buy it at Amazon. com. I just purchased some but have not tried it yet. The box does not have directions for smaller cakes so the proportions will need to be figured out before I can use it.
I have been experimenting with different brands due to the same problem. This is a solution I found at another site but I have not made it yet because I have not been able to locate Duncan Hines French vanilla cake mix. Last night I was able to order it from a website so once I receive it I will try it.
"I had to bake a double recipe of WASC last night. This is what I did different with excellent results. I used DH French Vanilla (is my favorite and it is still 18.25) I purchased two 3.4 oz of vanilla puding mix and added 2 tablespoon of 'extra' all purpose flour, I only use buttermilk (for my liquid) the rest of ingredients as the WASC calls for. I got perfect leveled cakes, beautiful color and NO HOLES>>> yeeeh.
Now, I usually do the DH French Vanilla, and when I did WASC (as indicated) I was getting those holes (and this is the one flavor that is still 18.25) so that means the mixes have been altered or reformulated even if the size is the same."
i am weighing it out seems to work for me with my wedding cakes.
ABake mark is a complete PITA to get a hold of. It took 5 days for them to get back with me, after I found a fax machine..(thought I was going to have to invent the time machine before I could fax it back) . Their ordering system and customer service is from 1985. They will email you a PDF application, which you have to print, fill out and fax back :eyeroll: Then, 5 days later, you get a phone call from some weirdo who you then have to call to place your order. No online ordering, and no price list!!! I got a 35 page PDF full of consonants jumbled together... No descriptions, pictures or prices. Several of the items I was wondering about are discontinued, while several items he told me about are new and haven't been added. They "may add them next year" , until then, you have to just ask for it by name.... Then, I drive up there, tell them my sales rep called in an order, and tell them who I am. I wait 15 minutes for them to get the pricing and print out an invoice, then wait 20 minutes for them to pull it, and after I WRITE A CHECK!!! or give them cash NO CREDIT OR DEBIT!!! then I can drive around back and wait another 10-15 minutes so they can put it in my van. There have been many times I am up there for well over an hour.
They have commercial DH mixes in white, yellow and chocolate, and also trans fat free. The white is white and fluffy and soft, and insubstantial. you add your own eggs, water and oil. The chocolate is dense and dry, and reddish.
The pillsbury white is soft and slightly chemically and vaguely yellow, you just add water and oil, eggs are in it. The chocolate is softer and fluffier and a rich hershey brown.
The DH is about $75 a 50lb bag. Pillsbury is about $65 a 50 lb bag. Prices fluctuate because these are "commodities" :eyeroll:
I have resigned myself to buying both chocolate and white in both brands. Mixing them together gets my customers what they are used to. For my white, I use 3lbs DH, and .5 lbs pillsbury, all egg white. For yellow, I use Pillsbury and DH, and use yolks for the eggs. For my apple spice, I use Pillsbury and a DH spice cake from the store. For pumpkin, I use Pillsbury and DH white with a DH spice..:. I have a chart I made to break down the ingredients into half, 1, 2, and 3.5 LB batches, and posted it on my fridge in my mixing area. Yes, it is a PITA!!!! I would kiss the Pilsbury people right on the mouth if they would go back to their regular mixes, or make it available in a 50 pound bag! ( I have very fresh breath, and am a good kisser;-D lol! )
Their domino powdered sugar is LUMPY!!! And must be sifted. I threw away a pound of lumps after I sifted them all out.
They have a brand of cake mix in the $58 range that tastes like how semen smells... I do not recommend it!! Blarg!!!
AI realize that DH has reduced theirs just as Pilsbury has, but I had to quit using Pilsbury all together. They would look great when I brought them out of the oven, then I'd come back, after cooling, to remove them from the pans and they had collapsed! DH doesn't do this for me. I used only Pilsbury for years!!! I contacted them and told them my problems, and that I was going to quit using their mixes. In a nut shell, they didn't care! So I now use only DH. The dark chocolate fudge tastes so much better than Pilsbury anyway :)
They may not care now but when they realize they have lost millions of dollars from lack of cake sales they may care later. I will never buy any cake boxes again!!! I have started to make mine from scratch only.
I don't see where the recipes posted have been adjusted to account for this size change. I am fearful of trying any of the recipes that are older than this change for fear they won't work properly.
I just found this thread when I went to the internet to see if anyone else was having trouble with Pillsbury since the change in the size of the cake mix. I own a bakery and have forever used 9 boxes of the 18.25 oz size of Pillsbury to mix a batch in my 20 quart hobart. But you guys are correct in saying that something has changed as well about the formula of the mix. I am still struggling to come up with something halfway presentable to the patrons of my business. I am having to add cake flour, sugar and baking powder and it has to be mixed very thoroughly and carefully by my bakers to come to any point acceptable by me. This takes much more time and effort as well as expense and it is still not as good as using the cake mix alone as it was before all the changes were made.
As far as the huge 50# bag that I can get from Bake Mark. This one has changed as well. It used to be a very good one in the 50 # bag, but this one has changed in that it is very, very salty. The rise is good on it, but it tastes like you are eating salty bread.
I have a cakecentral account or membership, but I don't come here often, so if anyone finds out anything that will get us back closer to the old cake mix, please let me know. I will be checking in a little more. Glad I found this thread!
They have white and devil's food cake mix at TBK, The Baker's Kitchen. Haven't tried either, but the white has great reviews; the other only has 1 review. You can order 2.5 pounds or a 25 pound bucket. I'm going to order some of each to try it out.
I haven't been taking much lately but had a granddaughters birthday this past weekend. Lots of problems with Pillsbury. I have used it in the WASC for years. My first came and cupcakes fell, re -baked the cake using two nails in 7" pan and adjusted the time. Came out better. Did 5 Dozen Cupcakes and thought everything was Okay They Tasted Awful. First Time People Didnt Eat My Cake So Embarrassed don't know what to do now. Any suggestions?
We all suffer embarrassment when something goes wrong. Sorry you had such a bad time. All I can suggest is use Betty Crocker mix. That's what I have used 99.9% of the time.


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Some examples of Confederate tributes around the South
Tributes to the Confederacy and the Jim Crow era that have existed still abound in the Deep South and beyond more than a century after the e…
Tributes to the Confederacy and the Jim Crow era that have existed still abound in the Deep South and beyond more than a century after the e…
When it comes to canine stars, like their human counterparts, sometimes it's all about the look.
"Ted 2" asks a question that we never needed, or particularly wanted, to know the answer to:
The nation's oldest and largest flag manufacturer has decided to stop making and selling the Confederate flag.
Trying to close in on two murderers who escaped from a maximum-security prison more than two weeks ago.
Sheriff's deputies in North Carolina had little trouble identifying a break-in suspect whose wallet and ID were left at the scene.
Will join leaders of other state universities in refusing to keep a raise recently approved by the Board of Regents.
Investigators are trying to determine why the driver of a pickup truck drove into the dugout at a baseball diamond in a Wichita suburb.
Police have identified a 38-year-old Hutchinson woman whose body was found in a creek bed.
A motorcyclist has died after colliding with a Missouri highway maintenance truck in Kansas City.
Sentenced to nearly two years in prison for being a felon in possession of a firearm.
A Kansas Highway Patrol trooper reached his 10,000th Twitter follower with a noteworthy addition.
Actor William Shatner is scheduled to pass through Wichita this week on a trip to raise money for the American Legion.
A ruling that overturned six convictions against a former Kansas doctor and his wife whose pain clinic is linked to 68 overdose deaths.
A long-running "border war" that saw both states using economic incentives to persuade businesses to move.
Organizers say they will be creating a human, peaceful barrier between the protesters and the families.
Protesters from several southern states have demanded politicians move to remove Confederate symbols from state grounds.
Police say they discovered a cache of weapons inside the home of the man they think is responsible for Monday's backyard explosion.
The report says Gray's death could not be ruled an accident and is instead a homicide because officers didn't follow safety procedures "thro…
It was 16 hours after Roof allegedly killed nine people.
Almost 30 law enforcement officers spent Wednesday morning searching for a man thought to be the subject of a police chase.
Tracking some more hot and humid weather before severe weather moves in tonight.
The Kansas average is $2.63 per gallon, 17 cents lower than the national average and 93 cents lower than last year at this time.


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Kitties!Science brain teasers require understanding of the physical or biological world and the laws that govern it.
A female purebred white cat and a male purebred black cat had a litter of 12 kittens. Out of the 12 kittens, all but 3 were black. How many female kittens were there?
HintBlack fur is a dominate allele
x= recessive: white
X= dominant: black
A purebred, female, white cat would have the alleles xx for fur color (white). A purebred, male, black cat would have the alleles YX (black).
The possible allele combinations for offspring are as follows (set up a Punnett Square)
Every female kitten would be black, with a recessive allele for white fur. Every male kitten would be white. There are 9 black kittens, so that means there are 9 female kittens.
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- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
Some people have used Facebook to broadcast things they are thankful for each day in the month of November. My wife is one of those people.
I'm not one of those people, but I have thought a lot about things for which I'm thankful during each day that my wife posted something.
What better place to list those things than on a public website, preserved for who-knows-how-long?
OK, here goes, in no particular order:
- My daughter, in general.
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So i wanted to try something pretty hard just to see if could do it. It didnt come out PERFECT. but darn good for never doing something like this before. Give it a look .
The Mess Up
Moderators: Timko, Fritz, Solty, Booter, Blake_T, Frank Delicious
AciDBatH666 wrote:actually, when that happened to one of my discs, i put contact paper all over the disc with lots of cracks and crevices in it and redyed it, and it gave it a marble floor look.
sleepy wrote:I sleepy, do hereby commit to use the Comet as my main midrange disc for a period of no less than one (1) year; commencing 11/24/09 and ending (if I so choose) on 11/24/10.
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History Told: The Father of Justice AND Dredd...
2000 AD is best known for its wild stories from the future, but with Judge Dredd: Origins, the comic publisher takes a rare look into the past... Judge Dredd's past, that is. Hitting bookstores today, March 19th, Judge Dredd: Origins takes readers all the back to January 9th, 1999 to witness the birth of Eustace Fargo, aka the Father of Justice, aka Judge Dredd's clone dad! From America's last President to the start of the Great Atom War, readers are taken on quite a turbulent journey through the history of Judge Dredd's future world. What's even better is that this entertaining blast into the past is all told within the context of a larger story, one that has Dredd seeking out the possible remains of Eustace Fargo himself.
Most 2000 AD Judge Dredd titles are a collection of stories by different writers and artists, albeit usually with a shared theme. Judge Dredd: Origins is unique in that it is entirely one continuous story primarily written and drawn by Judge Dredd's creators John Wagner and Carlos Ezquerra, respectively. Kev Walker does lend his awesome art to the introduction called "The Connection" (Progs 1500-1504), but it is "Origins" (Progs 1505-1519, 1529-1535) that encompasses 90% of the book. The streamlined result equals one of the most cohesive Dredd titles I've read; the action, story and art all packing a greater purpose from start to finish. And what a better team to tell such a crucial part of Judge Dredd's history than the creators of Judge Dredd themselves?
Admittedly, I tend to prefer my sci-fi void of broad backgrounds and explainations. Look what explaining "The Force" did for Star Wars... some things are best left to the imagination. Judge Dredd: Origins, however, delivers just the right amount of back story without stepping on your toes. Sure you'll finish reading knowing how the Judges came to be, but heck if you'll truly know the man behind the mask - the ever enigmatic Judge Dredd. It's that air of mystery - and the fact that anything goes - that keeps me coming back to Judge Dredd and his world. Pick up Judge Dredd: Origins and see how it all came it be...
Judge Dredd: Origins is priced at $19.99 (US) $22.99 (Canada). Grab your copy wherever the Galaxies Greatest Comic is sold.
Review by Jeff Saylor
Review Sample Courtesy of 2000 AD
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An Activist Battle Brews
In case you missed it on New Year's Day, activist investor Robert Chapman of Chapman Capital took a major shot across the bow of investor Bill Ackman: He announced that 35% of his fund's assets had been committed to a long position in Herbalife (HLF).
It's activist against activist....405 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
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Video: Lindsey Vonn Crash
Lindsey Vonn has already been released from a hospital after a crash at the 2013 FIS Alpine Ski World Championships in Schladming, Austria, according to the U.S. ski team. She was airlifted by helicopter to the hospital from the side of the mountain. Team medical director Kyle Wilkens says Vonn suffered two torn ligaments in her right knee, as well as a lateral tibial plateau fracture. She is expected to miss the rest of this season but her team expects her back for the 2013-14 season and the 2014 Sochi Olympics.
Universal Sports has provided video of the dramatic crash. Warning: The video's visuals are fairly tame, but the audio of Vonn's calls for help after the injury may not be for the squeamish.


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Most people have experienced feeling too tired to prepare a meal, or the comfortable convenience of fast food options. For many people with multiple sclerosis (MS), fatigue can be a persistent issue that leaves them feeling without a choice.
However, a little planning can make preparing healthy, fatigue-fighting meals possible. A small amount of preparation every week can go a long way in saving you time and energy and allow you to eat healthfully all week long. Start by sitting down each week and make a meal plan.
Here are some nutritious, easily prepared food ideas to consider to putting on your shopping list:


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Business News of Tuesday, 27 November 2012
Source: Abdul Karim Naatogmah
What appears to be the over-politicization of Cocobod's scholarship scheme for needy but brilliant children of the nation's cocoa farmers and staff of Cocobod has incurred their wrath.
Speaking on grounds of anonymity at this year's Copal-Day celebration at Agona-Swedru, the poor and angry cocoa farmers thoughtfully revealed that government functionaries have since 2009 hijacked the scheme.
"Since the change of government in 2009, the Cocobod scholarship scheme which used to support our poor children has been hijacked by Ministers and District chief Executives who are not part of our group," they complained.
They stressed, "Due to the politicization of the scheme, it has now become selective and what is even worrying is that we have to travel long distances to send our applications to the Cocobod head office in Accra."
They described the negative impact of the situation as unbearable saying, "Already we are poor and the situation has compelled most of our children to stop schooling because we cannot afford to pay their fees."
They have therefore resolved to vote massively for the New Patriotic Party (NPP) in this year's elections to get their children back to school courtesy Nana Addo Danquah Akufo Addo's flagship free SHS campaign promise.
"We are going out in our numbers to vote massively for Nana Akufo on December 7 to enable him implement his free SHS concept to enable our children have good education."
Backing the poor cocoa farmers standpoint, majority of Cocobod staff in an interview confirmed the scheme's politicization and therefore declared their unflinching support for Nana Addo's free SHS campaign promise.
They maintained that, "We are in full support of the free SHS concept and we consider it as something that will lessen our financial burden on catering for our children's education."
"Cocobod has since 2009 neglected its corporate and social responsibilities like provision of portable drinking water, school infrastructure and upgrading feeder roads in cocoa growing communities," they disclosed.
They further alleged that Cocobod's resources have been diverted into financing the ruling NDC campaign activities.
The Cocobod staff also chastised government for deceiving them at the Copal-Day event that a special bonus package awaited them which has not been delivered. "Whiles government staff are enjoying the Single-Spine Salary Structure, we the Cocobod staff who lay the golden eggs have been left out even though government announced a bonus package for us and cocoa farmers at the Copal-day durbar grounds."
Authorities at Cocobod have remained tight lipped on this matter at the time of going to bed.


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(Grilled Chicken with Lemon, Capers, and Oregano was updated with better photos and step-by-step instructions, June 2013.)
Grilled Zucchini or Grilled Mushrooms on the side?
Grilled Chicken with Lemon, Capers, and Oregano (Makes 4 servings, recipe adapted from 2001 Chicken Recipes.)
4 boneless-skinless chicken breasts, trimmed
Marinade Ingredients:
1/4 cup olive oil
2 T fresh squeezed lemon juice
1 tsp. dried oregano, crushed
1 tsp. garlic puree (or crushed fresh garlic)
1/2 T caper juice
2 T finely chopped capers (or use less if you're not wild about capers)
fresh ground black pepper to taste
(You might want to read how to make juicy and perfect grilled chicken breasts before you make this.)
Use a chef's knife to finely chop capers. Crush the oregano with a rolling pin or meat mallet. Mix together olive oil, lemon juice, oregano, garlic puree, caper juice, chopped capers, and black pepper. (You could also put all the marinade ingredients in a blender and process them rather than chopping the capers and crushing the oregano.)
Lay chicken flat in a large Ziploc bag and pour marinade over. Let chicken marinate in the refrigerator, preferably 4-6 hours or longer.
Spray the grill grates with non-stick spray, then preheat gas or charcoal grill to medium-high. (You can only hold your hand there for a few seconds at that temperature.) Lay the chicken pieces at an angle to the grill grates and cook for 3-4 minutes without moving. Then lift the edge of one piece of chicken to see if grill marks are as dark as you'd like them. When they look good, rotate the chicken to the opposite angle and cook 3-4 minutes more on the first side.
When you have good grill marks, turn chicken to the opposite side and cook 2-3 minutes more (or longer for very thick chicken breasts.) Chicken is done when it feels firm (but not hard) to the touch when you press down on it with your finger. Don't overcook. Serve hot.
This chicken could also be cooked in a stove-top grill pan with ridges or a George Foreman Grill with good results.
South Beach Suggestions:
Find More Recipes Like This One:
Nutritional Information?
More Delicious Dinners with Chicken:
(Recipes from other blogs not always low-carb or South Beach Diet friendly; check ingredients.)
Slow Cooker Chicken Recipes Photo Index Page ~ Slow Cooker from Scratch
Pan-Grilled Chicken with Green Olive, Caper, and Lemon Relish ~ Kalyn's Kitchen
Healthy Baked Mustard Lime Chicken ~ Elana's Pantry
(Want even more recipes? I find these recipes from other blogs using Food Blog Search.)
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Earlier this month, Mrs. Constance Ashford Wright contacted me and asked if Oglethorpe would be interested in a donation of a historic Broadwood piano that had belonged to her late husband, Tate Wright, Jr. Though Mrs. Wright has no direct connection to Oglethorpe, she indicated that her grandfather had provided to Dr. Thornwell Jacobs the property upon which the campus is located. This family is the "Ashford" of nearby Ashford-Dunwoody Road.
Both Dr. Brent Runnels, our affiliate artist in piano, and I were immediately intrigued and excited to see and hear the instrument. John Broadwood & Sons of London has been a maker of fine harpsichords and pianos for almost 300 years, and is one of the most prestigious companies for such in the world. The instruments have been enjoyed by musicians such as Mozart, Haydn, Chopin, Beethoven and Liszt. The company's use of metal string plates and a bolted iron frame provided more structural strength to the piano, along with additional power and volume—just one of the "firsts" credited to the Broadwood company that moved the evolution of the piano forward. The company holds the Royal Warrant as manufacturer of pianos to Queen Elizabeth II.
As soon as we saw and played the instrument, we knew we had a significant and historic find for Oglethorpe. Though out-of-tune, its action (keyboard mechanism) was in exceptionally good shape and its soundboard gave fleeting glimpses of its original, glorious tone. The entire piano with its exquisite rosewood case was in remarkably good condition. Handwritten mechanical notes on the bottom gives the impression that the piano was built around 1870 and perhaps earlier.
On Friday, May 18, the piano was moved from Mrs. Wright's home to the east wing of the Weltner Library's main floor. It is playable even as it is and we welcome those who wish to try it, as long as it does not disturb any library patrons. It is hoped that, in time, we may be able to rebuild the instrument so that its full, original, glorious sound may still be heard.
Next time you have a chance, stop by the Weltner Library to see this piece of history!
Dr. W. Irwin Ray is Director of Musical Activities at Oglethorpe University.


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Downloadable Exo Terra Turtle Filter FX 200 Instruction Manual PDF.
Please click on "More Information" for Turtle Filter FX 200 filter media maintenance guide.


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Five Of A KindRiddles are little poems or phrases that pose a question that needs answering. Riddles frequently rhyme, but this is not a requirement.
The first is needed to make quotes you see,
And it often sticks up when it's time for noon tea.
The second's biggest distinction is found
Bearing the symbol of love that is bound.
The third should be biggest but that can depend,
Never standing alone or it may offend.
The fourth is oft used when making a selection
Or if you should need a gun for protection.
The fifth is the fattest and oddest by far,
And can sometimes be found in a wrestling war.
What are they?
HintA hint would just be handing it to you.
AnswerThe digits of the hand! (The order on the poem is pinky, ring finger, middle finger, index or pointer finger, and thumb)
The pinky hits the quotation mark key on the keyboard when typing, and people often raise their pinky off the cup when drinking tea. The ring finger bears a wedding band when married. The middle finger is an obscene gesture when standing alone. You point with the index finger to make a selection, or use it to pull the trigger on a gun. The thumb can be used for thumb wrestling.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this riddle, keep track of
which ones you have seen, and even make your own.
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Mark Ellis wrote:When Discraft first allowed me to make a batch of custom gripstamps...
That's new information. If the PDGA inspected and ruled, then I have no issue and that's not quite what I was discussing.
Mark Ellis wrote:PDGA rules are often criticized for being incomplete and not fully addressing issues. Our aged grandfather (Ball Golf) has VOLUMES of rules and hordes of officials to enforce them.
I don't think that's accurate. Every sport that's been around for awhile and is several levels above "beer pong" has lengthy rules books. Golf's is no longer or than the NFL's, NHL's, MLB's, etc. And even a PGA Tour event with 156 player fields only has two or three actual rules officials. Walking officials are often assigned (and only sometimes used) during some majors as a convenience and pace of play.
Mark Ellis wrote:Our rules fit in a small pamphlet we can easily carry with us and we are mostly self-officiated. Our rules try (and usually succeed) in being simple and clear. They don't cover every conceivable situation but create principles which can be fairly applied when odd occurrences pop up. We could "lawyer up" our rules if we choose. How many things in life improve with more lawyers involved?
Oh brother. The PDGA rules will likely become increasingly complex as the sport continues to grow. There will be a desire for those "situations" to be covered.
Mark Ellis wrote:All these methods can make a disc more under or overstable but otherwise doesn't change the flight characteristics in any useful way.
That's an opinion. Clearly the flight characteristics of the discs were changed. And for the record I don't have any problem whatsoever with someone modifying a disc. Heck, you can bend it in your hands as part of your pre-shot routine to affect the flight of the disc. That kind of modification doesn't matter, but it's against the rules as they're written.
The rules simply say "Players may not make post-production modifications of discs which alter their original flight characteristics." Bending a disc as part of your pre-shot routine doesn't gall me, but a strict interpretation of the rule says that even THAT would be illegal. It doesn't take a strict reading of those rules to see how boiling and doing other things that noticeably change the shape of the disc would be illegal "post-production modifications which alter their original flight characteristics."
This is especially important given the rule for 2013 where a disc whose legality is questioned is unavailable to that player until a TD makes a ruling. In my opinion you can't put THAT rule in place while having sloppy, loosely defined rules on what makes a disc legal or illegal.
Now, I'm perfectly willing to believe that disc golf is filled with people that simply look the other way in a "we all do it" kinda fashion. Though I personally prefer to adhere to the rules very strictly myself in the sports I play, the one time I've ever called someone on a rules violation in my years of competitive golf was actually pre-emptive to prevent him from getting a penalty. I've looked the other way on the few rules infractions (all in match play - in stroke play I have the obligation to protect the field) I've seen, often because I was winning already and I found it sad that someone would feel the need to cheat at a game.
Mark Ellis wrote:PDGA Technical Standard testing is purposely low tech, easy and inexpensive. Ball Golf scoffs at this. Fine, let it scoff. My driver costs under $20.
I don't believe that it's "purposely" low tech. I think it's "low tech" simply because there's no money in disc golf. There's simply not enough money (and thus not enough demand from pros and consumers) to enforce tighter standards, but the key phrase there is "enforce," not "standards." The standards are written. They're out there. It's just impractical to have a scale at every tournament, and customers and pros aren't requiring manufacturers to adhere to strict standards, because everyone just looks the other way.
Mark Ellis wrote:You might have the concept somewhat off. Discs, per se, are not approved. Molds are approved. So any disc made from an approved mold is also approved.
I understand the distinction. An approved mold can still result in an illegal disc, specifically if post-production modifications are made. Hot stamping is not part of the mold, nor is a disc that's overweight but made from a legal mold. A disc with a hole punched in it, a disc with detectable thickness stickers applied, a disc that's been cut, overly sanded, had its "original flight characteristics altered," etc. are all illegal discs.
Mark Ellis wrote:As far as hotstamping goes it does not change the weight, stiffness or rim configuration of a disc. The danger of doing a poor job with a grip stamp is that the disc can become warped or the flight plate could be burned through. Neither of these mistakes gives any advantage in terms of flight characteristics and just means the poor disc is doomed to the regrind box.
Mark, the rules do not say "give an advantage" (which is subjective anyway - a disc that becomes more understable after some procedure might not suit you but may be just what someone else wants). They say "alter their original flight characteristics."


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Topic: Hello, I am new to the site
I am a friend of someone who just found out that he has this cancer. He just went through the biopsy, now off to the races. I spend at least 4 days a week with this friend and his wife. They have become like the family
I am totally upset by this news. If you have any advice for me I welcome it. I have been researching this online and this is how I found your group. Thanks for any help you may pass my way.


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Editor's note: Last in a series on bovine lung immunology.
Boosting lung defenses can include things like low-stress handling and timely use of respiratory vaccines. Dozens of vaccines are available for use in cattle but you can't get "immunity in a bottle" without strategic timing and proper management.
If the viral infections are the first ones to start compromising the innate defenses, then clearly immunity to the viruses can play a very important role in minimizing the risk of fatal respiratory infections, says Philip Griebel, DVM, PhD, Vaccine and Infectious Disease Organization, University of Saskatchewan. "Vaccines are not a magic bullet, but what they're doing is raising the threshold of disease susceptibility. They will increase the threshold for an effective challenge dose. Animals need to be exposed to a greater amount of virus for a greater period of time to overcome immune defenses, before the virus starts to impact lung defenses." Vaccines can also decrease virus transmission within a group, so they can individually raise the threshold of disease susceptibility for individual animals as well as enhance herd immunity by decreasing the efficiency of virus transmission.
Breck Hunsaker, DVM, PhD, Livestock Consulting Services and Horton Research Center, Wellington, Colo., says there is broad support and use of viral vaccines by feedyard managers; however, some feedyards might rely too much on them, based on reported research that questions vaccine efficacy. "Some of our feedyard managers want to vaccinate and revaccinate and revaccinate, if you let them, with viral vaccines. You have to remind them that timing of administration is critical."
But vaccines alone can't do it, and can be overwhelmed. Feedlot vaccination includes onset of immunity, magnitude of response, and duration of immune protection. Vaccines have to be delivered strategically relative to the risk period. "Inducing an immune response isn't sufficient," Griebel states. "We have to think about the idea of protective immunity. If we vaccinate on arrival, is that too late? It will depend on the exposure. There is now evidence that some of the modified-live viral vaccines can induce protective immunity within five days. But the effectiveness of this vaccination will depend on where those calves are in that infection cycle. We need to think about vaccines very strategically, relative to risk period."
Timing of killed vaccines
Research confirms that bacterial vaccines can also prevent fatal respiratory infections, Griebel says." If you look at vaccines for Mannheimia, and the bacterial leukotoxins, it is clear that these vaccines prevent fatal pneumonia. The bacteria causes lung inflammation and abscessation which severely compromises respiratory function. This lung damage can be sufficient to cause animals to die because there isn't effective oxygen exchange. Again, bacterial vaccines can raise that threshold of disease susceptibility."
A killed vaccine, because it has limited antigen load, often requires double immunization to induce an immune response which is protective, Griebel explains. "The standard immunization protocol for most killed vaccines is a two-shot regimen. So the single shot on entry won't achieve that protective level, whereas the modified-live viral vaccines amplify the amount of antigen and has all the danger signals, supplied by adjuvants in killed vaccines. This enables modified-live vaccines to induce protective immunity much more quickly."
Kip Lukasiewicz, Sandhills Cattle Consultants, Inc., Ainsworth, Neb., believes the time and place to most effectively use bacterins such as Mannheimia, Pasteurella and Histophilus vaccines is on the ranch two to three weeks prior to weaning. "There's a lot to be said for the timeliness of when it's given," he says. "On the ranch, we recommend Histophilus, Pasteurella and others while the calves are still on the cows and their stress level is very low. They have ample opportunity to acquire a good immune response at that time."
Lukasiewicz says his experience with Histophilus breaks in a couple of yards over the last few years with myocardial lesions and heart failures was controlled by cleaning pens better and better pen management since Histophilus is shed through feces, urine, nasal secretions, etc. "This year we haven't had one Histophilus case out of that yard, whereas last year I already had about 14."
Hunsaker believes because those are killed agents, the timing is much more critical with a bacterin, with a killed agent, than it is with a modified-live antigen. He says there has also been some work done on looking at interference between modified-live vaccine and some Pasteurella/Mannheimia bacterins. "We talk about immune response like it's an antibody response and I don't think those two terms are really interchangeable," he says. "Immunity is really protection, but if we were to use a modified-live at branding and a Pasteurella or a bacterin pre-weaning, would that timing be more suitable for what we're trying to achieve? When both are given at the same time — if there truly is interference clinically between those two antigens — then maybe we're not doing ourselves any favor by giving them both."
Griebel explains that work done by Richard Harland indicated that if vaccines are given in two different sites, such as opposite sides of the neck, there isn't interference. "You can give them at the same time and not have interference. I think it's important that people know that they can give both vaccinations if they are at separate sites." Griebel notes that this work was done with a modified-live IBR/PI3 only.
The ability to neutralize leukotoxins and endotoxins are critical for success when using bacterins, adds D. Scott McVey, DVM, PhD, Veterinary Diagnostic Center, University of Nebraska. That's where we've seen improvement over the last 20 years, like the improvement with the Mannheimia bacterin/toxoids. They're much better than they used to be. Beyond that, antibodies to many different somatic factors that potentially enhance clearance are important. There are a lot of disclaimers and caveats. We've already talked about the weaknesses of bacterial challenge models. We take normal animals and, for experimental purposes, put a ton of bacteria down in the respiratory tract, and then look at usually what counts for registration of a vaccine — comparative lung lesion scores in vaccinates and non-vaccinates. Antibody titers and serologic responses don't often correlate all that well to that protective response."
But even under the best of circumstances, what you see is a reduction of 50% to 80% in the lung lesion scores, McVey says. "It's not sterilizing immunity and it is generally not very effective. On the other hand, most immune responses, under optimal circumstances to viral vaccines — BHV1, BVD — are pretty good. You can knock down shedding and viremia to almost zero."
If you compromise the timing of the administration strategically, if you compromise the immune system, it's not surprising that cattle get overwhelmed with the bacterial infections, McVey says. "We have much better vaccines than they used to be. There is a real research opportunity to define clinically relevant challenge model systems for Histophilus somnus."
Immunology and treatment
Treatment of bovine respiratory disease hits a feedlot hard economically in drug cost, labor, and performance and mortality of cattle. Sometimes treatment is a guessing game when it's unknown which pathogens are to blame, and the wrong treatment can be of further detriment to the animal.
Griebel explains that for Mannheimia infections, for example, recruitment of neutrophils is a death sentence, because they can activate a massive inflammatory response causing the destruction of lung tissue. "As a clinical veterinarian, you may not know what's in that lung. If you knew that it was Mannheimia, then an anti-inflammatory may be absolutely critical. But if there is a Pasteurella multocida infection and it's being contained by neutrophils, then treating with a corticosteroid may cause the Pasteurella multocida to spread through the lung. We're dealing with a multi-factorial disease in terms of etiology and many of these therapeutic interventions may be very good for one bacterial infection and may make the disease much worse for another one. We just don't have the diagnostic tools to know what's down in that lung."
And even the right drugs won't restore the lung to its original state. "Some people buying and using antimicrobial therapies think they are making the lung all new again, that it restores normal function, but it doesn't," Hunsaker says. "That's a tough concept to get across. Once irreversible damage hasbeen done, we just want to minimize that. You may get sudden death of an animal that was treated three months ago. That lung probably supported a 400- or a 500-pound carcass, but it doesn't support an 800-pound carcass and that's frustrating for the managers because they've spent money on therapy."
MICs and sensitivity testing
For antibiotics to be effective, it is necessary to maintain a minimum inhibitory concentration. "We must consider the pharmacokinetics of antibiotic therapy," Griebel states. "I think the failures in lung delivery are often about timing of treatment. When bacteria in the lung enter log-phase growth, we're fighting a losing battle." If we treat too early and our minimum inhibitory concentration has dropped, or if we come in too late and the extent of lung damage has reached a point where antibiotics can't enter the site of infection, then their efficacy is compromised.
And if you're too early, Hunsaker adds, you may disrupt or interfere with the commensal population to the extent that you allow an opportunity for pathogens to invade.
What frustrates Lukasiewicz are MIC and sensitivity levels of antibiotics. "You can have in vitro MICs that indicate resistance, but then you use the antibiotic in vivo and the anti-biotic works," he says. "It's resistant in the Petri dish, but it's working in the animal. So is it the animal's ability to metabolize that antibiotic and get it to the area that needs to be addressed?"
Chase answers that by saying there has been work with some antibiotics that shows that macrophages will concentrate some of these drugs. "You just can't use in vitro testing alone. In vitro testing can be very misleading."
McVey notes that with sensitivity testing, it very much depends on bug-drug interactions. "I find those kinds of measurements more useful in an epidemiological sense as opposed to a therapeutic sense."
"The whole concept of sensitivity testing and using that as more than just one piece of information is contrary to what we're talking about in this multi-factorial setting," Hunsaker adds. "We have a number of things going on and now we've isolated one bug in a lab environment in a Petri dish or a blood agar plate and then making an assessment of that bug in that environment versus the multi-factorial environment of the lung. It is tough to make that leap accurately."
Another issue is actually getting the antibiotics to the bacteria. "Various bacteria are very good at creating barriers," Griebel says. "We've talked about how Pasteurella multocida can create an abscess, and if there's no blood flow, then there's no antibiotic delivery."
Post-treatment care
With the antibiotics available, Lukasiewicz says that some people may have the impression if they use an antibiotic that lasts seven to 10 days, they can ignore that animal for seven to 10 days. "It goes back to post-treatment care and animal husbandry, observing those animals on a daily basis," he says. "Sometimes you need to recognize that you might have to bring them back in the following day and re-drench them or provide an anti-inflammatory — not necessarily giving them another antibiotic, but giving them something to help them out and feel better."
Some people think every animal in the population is the same and they'll all respond, but they're all in a different place on that morbidity curve or in the incubation phase," adds Hunsaker. "To consider they all ought to be treated the same is probably misleading."
Antimicrobials may reduce the number of bacteria, but the animal has to heal itself. Post-treatment care is probably the most important — clean water, a clean pen, adequate feed, and a palatable feed source. Lukasiewicz believes the best medicine of all is free-choice prairie hay. "You want your hospital to be clean. Sometimes they have a better chance of surviving by going back to their home pen instead of staying in the hospital." Lukasiewicz only wants to leave extremely ill or special-needs cattle in the hospital pen if he can.
But sometimes hospital cattle get ignored, and Lukasiewicz reminds that they need special attention. "We shouldn't forget the individual animal. If you or I go into a hospital, they're not going to let us lie in bed and forget about us. Ask the animal to get up and move around. Ask the cowboys or cowgirls to have compassion. Provide a palatable ration. Having hot and cold rations in the hospital is extremely important. Some yards just use leftovers for the hospital. That's called laziness, not management. If you're going to have a hospital system, then you'd better manage it. If you have cattle on a cold ration and you give them a ration number five, it's like giving them a chocolate bar. I don't recall going to the hospital and getting a chocolate bar. It upsets the digestive tract. And then we take them back to the pen and they fall back a ration causing inconsistencies."
If cattle are to stay in the hospital pen versus going back to the home pen, Hunsaker cautions that it takes excellent hospital pen management. "I see hospital pen management as being an afterthought because it's not a profit center," he says. "The things the cattle have to deal with there are changes in ration, metabolic challenges, re-socialization, and then you've basically created a miniature version of a sale-barn environment. We have cattle in the hospital from multiple sources and we bring them in to get them better, but what we really do is create fomites and it becomes an overwhelming challenge."
Overcrowding of hospital pens on feedlots is a common problem. "Why would you put a sick animal in a pen designed for 10 and then place 50 sick animals in it?" Lukasiewicz asks. He would rather see them back in their home pen with their peers. "Cattle are extremely social animals. They have behavior patterns throughout the day. There's social licking where they groom each other. They have their little cliques. That social component is really huge."
Generally, hospital pens require more pen space and more bunk space to be more conducive to healing. "Typically, they put a hay ring in the hospital and they put cattle that weigh 800 pounds in with cattle that weigh 300 pounds," notes Hunsaker. "They put lame cattle in with the respiratory cases and it's just not an environment conducive to healing. It's like a place to get them out of sight and out of mind."
"People are becoming very sensitive to how we treat animals," Lukasiewicz adds. "With labor issues as they are, trying to reduce our level of illness is a major obstacle. If we utilize some low-stress techniques in our daily routine, we may find that we spend less time pulling and treating sick cattle and spend more time creating a positive environment for those animals."
Where do NSAIDs fit in?
Non-steroidal anti-inflammatories (NSAIDs) are sometimes used in supportive care for feedlot respiratory disease. "I think the issue of supportive therapy is critical," says Philip Griebel, DVM, PhD. "Antibiotics are buying calves time, but in the end, it's the host's defenses that must clear the infection. If we're not supporting those defenses, the immune functions, then the antibiotic will run its course and bacteria will survive. All we've done is delayed the problem and maybe reduced the magnitude of it. Unless there are proper supportive therapies to bring in the immune defenses to clear the infection, then the problem won't resolve."
Breck Hunsaker, DVM, PhD, adds that work has been done to show that NSAIDs do modulate neutrophilic infiltration. "We talked about the benefits and maybe more important the deleterious effects of those neutrophils. If we can tip the scale in favor of pulmonary macrophages and gamma-delta T-cells to modulate that neutrophilic response, maybe there's an opportunity to enhance the healing process."
Unfortunately it gets back to the redundancy of the inflammatory pathways, notes Chris Chase, DVM, PhD. "We know that non-steroidals affect certain areas, and that's good. There's an upside in terms of knocking down some of those inflammatory pathways. They are very specific, versus steroids, which are not very specific. You can choose the pathway where it's involved, so from a strategic standpoint, there are some advantages."
NSAIDs aren't the only answer for pain relief, adds Kip Lukasiewicz, DVM. "We have the non-steroidals that provide some pain support, but for how long? Sometimes just getting them to get up and move around and loosening up the joints is better pain control. If you have knee surgery, they have you moving that knee within an hour or two after surgery. Getting those animals up and asking them to move around the pens works."
D. Scott McVey, DVM, PhD, agrees. "I think there probably are some yet-to-be-understood factors in using that type of therapy," he says. "A lot of it probably is timing. It's a tool we don't know enough about."
"If we choose pain relief, as veterinarians we need to be aware that we rely very much on clinical symptoms because we can't talk to the animals," cautions Griebel. "If we mask the clinical signs, that may leave us in a very difficult situation when evaluating animals' response to therapy."
This information is from a Bovine Veterinarian roundtable sponsored by Intervet/Schering-Plough, moderated by Jessica Laurin, DVM.


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Video Linux Voice is a New Magazine for Linux Users — On Paper (Video) 72
Graham Morrison, who is one of four people behind the shiny-new Linux Voice magazine, which is printed on (gasp) paper. Yes, paper, even though it's 2014 and a lot of people believe the idea of publishing a physical newspaper or magazine is dead. But, Graham says, when you have a tight community (like Linux users and developers) you have an opportunity to make a successful magazine for that community. This is a crowdfunded venture, through Indiegogo, where they hoped to raise £90,000 -- but ended up with £127,603, which is approximately $214,288 as of this video's publishing date. So they have a little capital to work with. Also note: these are not publishing neophytes. All four of the main people behind Linux Voice used to work on the well-regarded Linux Format magazine. Graham says they're getting subscribers and newsstand sales at a healthy rate, so they're happily optimistic about their magazine's future. (Here's an alternate video link)


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They came out of a commercial break on the Tuesday night edition of "Fox Sports Live," and co-hosts Dan O'Toole and Jay Onrait were sporting one of those looks as if they were about to deal with a very serious topic, but had nothing really of value to bring to the conversation.
"This is Fox Sports Live, and yes, we do have a lot of stuff on the screens," O'Toole said.
"Soon you won't be able to see us at all," continued Onrait, shifting in his chair and squinting his eyes – and, in some ways, giving the viewers something to hope for.
"And then we can finally do this show wearing nothing but a pair of Donovan McNabb's multicolored socks. Until then, let's take a trip around the National Football League."
But seriously …
About that seizure-inducing screen, with that fluorescent graphic box on the right mentioning something about Yasiel Puig's favorite food, a scroll across the bottom delivering some UFC results in two very long sentences that no one can possibly read before it disappears, and more graphics underneath the anchors giving us their Twitter handles, because for all we know, they're tweeting under the desk where we can't see their hands.
Plus, there's a promo for another show on the bottom right corner, which could have been better used if a local ophthalmologist bought the space as an advertisement for his business.
Is this the Bloomberg News stock report, or is there actually a Dodgers-Marlins score buried in there somewhere?
It's probably not polite to begin thrashing and bashing away at something that's just up and running after a few days – that's true whether it's a Fontana food truck, Tarzana tanning salon or Glendora gentleman's club.
But in a way, Fox seems to have forced us into doing this. Almost as forced as most of the scripted ad-lib jokes that the anchors, panelists and hosts are trying to pass off as party favors.
Do us a favor already: Stop trying so hard.
Some of the early reviews should be telling.
One from Slate: "Everything on FS1 is acceptable without being remarkable."
Another from the Hollywood Reporter: "Welcome to the crowded field, Fox Sports 1. You blend in well."
And this from the actual Bloomberg Business News: "Fox Sports 1 will rise or fall according to the games on the field and not the games in the studio."
They obviously haven't been watching as much as we have forced ourselves to do in a "Clockwork Orange" fashion that simply isn't healthy, even if you try to supplement the experience with some of Erin Andrews' prescribed probiotics and energy boost drinks.
The honeymoon period isn't over for us with FS1 and FS2, the latter of which we haven't even located on the menu yet but we have been told will offer up as its main event this weekend some women's pro soccer league playoffs.
Honestly, our first impressions are clouded a bit by hearing the voice in our head of a former employee who told us recently the way he saw this whole thing playing out based on the company's recycling of ideas, talent and second-tier live events: Same garbage, different bags.
Not all of it is trashy, though. Something, perhaps, can be composted. Check with your local waste management provider.
Our immediate checklist of do's and dont's if you must watch from here on out until college football begins:
• "Crowd Goes Wild" could have a longer run than "The Magic Hour," if only because the network can't bring itself to carry out the euthanasia process (legal in California?) because it has invested too much in the start-up fees.
Here seems to be the premise: Four panelists try to teach Regis Philbin each day about what's cool in sports. And the 81-year-old is just content with looking into the camera, shrugging and cracking a smile, then looking off camera to see if Gelman is there to bail him out.
Georgie Thompson is no Kelly Ripa, but close enough with a British accent that could be supplemented with a closed-caption translation. Michael Kosta could badly use a joke writer, or continue to write his own bad jokes. Jason Gay appears to be a character from an old "Kids In The Hall" sketch. And Trevor Pryce might just eat them all up for lunch if the mood strikes.
• Katie Nolan? OK, Katie Nolan. Text me when you're finished.
• If has-been Terrell Owens, a guest on Tuesday's version of "CGW," is trying to work his way onto the "Fox Football Daily" show, he won't be knocking Randy Moss of his crossing pattern any time soon.
• "FFD" has not mentioned Tim Tebow yet, as far as we know. Bless you, Jay Glazer. And it's OK to talk now, Brian Urlacher, especially if you think someday you could sub in for Howie Long on the "NFL on Fox" set.
• Mike Tyson can't be on every show, every day. But they could try. And it still wouldn't be compelling, no matter how many times he curses or promotes his latest project.
• Charissa Thompson could try to be on every show, every day, by herself. Not saying a word. Just sitting there. Like a greeter at Red Robin. And we'd be fine with that.
• Gabe Kapler should leave immediately to the MLB Network and replace Harold Reynolds.
• O'Toole and Onrait are the Not-Ready-For-Prime-Time players who should be smart enough to realize they could carry this thing if they don't get carried away with themselves.
• Can't say we've seen anything remarkable with the Fox soccer studio show, other than Eric Wynalda continues to be enamored with the cadence of his voice.
And just so you know, ESPN folks in Bristol, Conn., have been watching, and even commenting, on what they see so far.
ESPN is in the middle of hosting a media junket, giving access to how they attempt to do things. The most profound response came from ESPN president John Skipper, when asked why FS1 is only charging 23 cents a subscriber (for now) while ESPN manages to get in excess of $5 per sub per month:
"I'm happy for them. In 35 years they may find that compound increases are quite profound."
That's assuming quite a bit at this juncture. Check back with us after 35 days.
A remote way of gauging the media's high- and low-level marks of the week:
Too bad Maria "Sugarpova" Sharapova has exited the U.S. Open already because of an injury. She could help sell ESPN Films' final installment of its espnW "Nine for IX" series called "Branded." The way the ESPN marketing department is framing this one: "Sports are supposed to be the ultimate level playing field, but in the media and on Madison Avenue, sometimes looks matters more than accomplishments." Co-directors Heidi Ewing and Rachel Grady have framed this examination of double standards (often reinforced by ESPN's own daily debate shows) by interviewing such former athletes as Lisa Leslie, Laila Ali, Brandi Chastain, Mary Lou Retton and Gabby Reece, plus current track star Lolo Jones and soccer vixen Hope Solo. The doc debuts Tuesday at 5 p.m. on ESPN.
The NFL's contract with the coveted "NFL Sunday Ticket" doesn't end with DirecTV until after the 2014 season – marking a 20-year run since the two have paired up for this all-encompassing pay-package for out-of-market games. Since DirecTV pays a reported $1 billion a year for its exclusivity, there is talk the dish company has no intentions of paying any more in renewed rights fees (thought to be in the $1.5 billion range), meaning it could finally agree to share it with a cable partner. Or, if the league gets a little daring, perhaps Google and its YouTube live streaming assets could be brought into the mix. Do a Google search on reports that NFL commissioner Roger Goodell and his team had dropped by the company's headquarters, and you'll see the league would only admit that officials "meet often with innovative leaders in Silicon Valley and around the world. We are constantly looking for ways to make our game better on the field, in the stadium and for fans. We are not commenting on any specifics of the meetings."
During Tuesday's Dodger telecast from Miami on KCAL-Channel 9, play-by-play man Eric Collins brought up the anniversary of the day in 1974 when Davey Lopes "had arguably the best offensive day in L.A. Dodger history" – a team-record 15 total bases, coming from three homers, a double and a single against the Cubs at Wrigley Field. The argument arrived quickly. A half hour later, Collins said he wanted "to clean up something" about that Lopes note, crediting someone named Pamela Wilson (presumably a viewer who somehow got the word to the broadcast) for "pointing out" that once upon a time, Shawn Green broke Lopes' team record with 19 total bases. Actually, Green set a major-league record, the result of a major-league tying four home runs to go with a double and single in a win at Milwaukee in 2002. "How did we forget that?" Collins asked, presumably dragging in partner, Steve Lyons, who also seemed to be guilty of cluelessness. "In our haste to praise Davey Lopes, we forgot Shawn Green. Thank you, Pamela, for keeping me on my toes." In our haste to be critical of this Dodger broadcast team, we also pray silently that they are not involved in the new Dodger-owned channel coming in 2014.
firstname.lastname@example.com twitter.com/tomhoffarth


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Efficacy and Safety of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Duodenal Ulcer
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: September 16, 2011
Last updated: August 19, 2013
Last verified: August 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to determine the efficacy of TAK-438, once daily (QD), compared to lansoprazole in patients with duodenal ulcer.
|Duodenal Ulcer
|Drug: TAK-438 Drug: Placebo Drug: Lansoprazole
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Phase 3, Randomized, Double Blind, Double-Dummy, Multicenter, Parallel Group Comparison Study to on Efficacy and Safety of Oral Once-Daily Administration of TAK-438 20 mg Comparing With AG-1749 in Patients With Duodenal Ulcer
Resource links provided by NLM:
Drug Information available for: Lansoprazole DexlansoprazoleU.S. FDA Resources
Further study details as provided by Takeda:
Primary Outcome Measures:
- Endoscopic Healing Rate of Duodenal Ulcer Over 6 Weeks [ Time Frame: 6 weeks ]Endoscopic healing rate : Rate of participants who have endoscopically confirmed all of the white coatings disappeared.
Secondary Outcome Measures:
- Endoscopic healing Rates of Duodenal Ulcer on Endoscopy over 4 weeks [ Time Frame: 4 weeks ]
- Endoscopic healing Rates of Gastric Ulcer on Endoscopy at week 2 [ Time Frame: 2 weeks ]
- Change from Baseline in the Incidence of Gastrointestinal Symptoms Associated with Duodenal Ulcer [ Time Frame: Baseline and 6 weeks ]
|Study Start Date:
|October 2011
|Study Completion Date:
|February 2013
|Primary Completion Date:
|February 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: TAK-438 20 mg QD
Drug: TAK-438
TAK-438 20 mg, tablets, orally, once daily for up to 6 weeks.Drug: Placebo
Lansoprazole placebo-matching capsules, orally, once daily for up to 6 weeks.
|Active Comparator: Lansoprazole 30 mg QD
Drug: Lansoprazole
Lansoprazole 30 mg, capsules, orally, once daily for up to 6 weeks.
Other Name: AG-1749Drug: Placebo
TAK-438 placebo-matching tablets, orally, once daily for up to 6 weeks.
|Ages Eligible for Study:
|20 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Participants must have endoscopically confirmed duodenal ulcers (mucosal defect with white coating) .At least one ulcer with white coating of 5 mm or larger in size should be observed at baseline (Visit 1).
- Outpatient (including short inpatient for examination and others)
Exclusion Criteria:
- Participants with a gastric ulcer which is suspected to be malignant on endoscopy at baseline (Visit 1)
- Participants with an Acute Duodenal Mucosal Lesion (ADML) on endoscopy at baseline (Visit 1)
- Participants with a linear ulcer (including scarring) on endoscopy at baseline (Visit 1)
- Participants with a postoperative ulcer (e.g., Ulcer after EMR/ESD) on endoscopy at baseline (Visit 1)
- Participants with a gastric ulcer on endoscopy at baseline (Visit 1)
- Participants with an ulcer for which medical treatment is not indicated (e.g.,perforation, pyloric stenosis, duodenal stenosis, large hemorrhage)
- Participants who have received endoscopic hemostasis for gastric ulcer within 30 days prior to baseline (Visit 1)
- Participants with a previous or current history of Zollinger-Ellison syndrome, or other gastric acid hypersecretion disorders
- Participants who have received or who are scheduled to undergo surgery which affects gastric acid secretion (e.g., resection of upper gastrointestinal tract, vagotomy)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01452724
Show 64 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01452724
Show 64 Study Locations
Sponsors and Collaborators
|Study Director:
|Senior Manager
More Information
Keywords provided by Takeda:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01452724 History of Changes
|Other Study ID Numbers:
U1111-1123-8648 ( Registry Identifier: WHO )
JapicCTI-111608 ( Registry Identifier: JapicCTI )
|Study First Received:
|September 16, 2011
|Last Updated:
|August 19, 2013
Keywords provided by Takeda:
Drug Therapy
Additional relevant MeSH terms:
Duodenal Ulcer
Pathologic Processes
Peptic Ulcer
Duodenal Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Stomach Diseases
Anti-Ulcer Agents
Gastrointestinal Agents
Proton Pump Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017