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<img src="http://openwetware.org/

Fig 8. Fluorescence measurements to study lock function

Fig 8. Fluorescence measurements to study lock function

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- Lock and Key
- Experimental Methods
- Challenges Faced
The Search for Locks and Keys
After designing our DNA origami box, we started looking for a suitable "lock and key" system. With a suitable lock and key, we would be able to open a closed origami box, as shown in Fig. 1.

Fig. 1 When the lock and key interact, the origami box opens.
For our purposes, we adapted the lock and key system based on the specific binding of PDGF (Platelet Derived Growth Factor) to an aptamer strand. Such a system has been successfully used for a similar application (Douglas et al., Science 17 Feb 2012, Vol 335: 831-834). Aptamers are artificial specific oligonucleotides, DNA or RNA, with the ability to bind to non-nucleic acid target molecules, such as peptides, proteins, drugs, organic and inorganic molecules or even whole cells, with high affinity and specificity (Mairal et al., Anal Bioanal Chem 2008, 390: 989–1007). PDGF is one of the numerous proteins regulating cell growth and division. It is considered a potent activator for the cell types essential for tissue repair and wound healing (GF. Pierce et al., Biochem Apr 1991, 45 (4): 319-26). In our system, we used a PDGF-specific aptamer based locking system, as described by Douglas et al. Each lock is essentially composed of two complementary oligonuleotidic strands - an aptamer strand specific to PDGF and a strand complementary to it.
Aptamer strand:
Aptamer locking strand:

When Human PDGF-BB interacts with such a hybrid, it associates with the aptamer strand and the two strands of the lock dissociate. In other words, the complementary
strand is displaced by PDGF because it has a higher affinity to the aptamer (Kd = 0.129±0.011 nM) (Green et al., Biochemistry 1996, 35: 14413-14424). To enhance the efficiency of the system, the aptamer locking strand is designed to
be partially complementary to the aptamer strand. Such a design with shorter complementary sequences (24 bp) combined with a stretch of 16 mismatches between the two strands, increases the rate of interaction between the aptamer and PDGF.
However, the lock is still stable enough when the Origami box is closed. The locks were hence designed as described in Fig. 2(a). The two
strands of the lock are attached to the the origami box by means of origami attachment sequences, complementary to the origami scaffold.

In order to see how efficiently this lock and key system works we had to come up with an assay to characterize its functioning. To actualize this,
Black Hole Quencher (BHQ) labeled aptamer strands and Cyanine 3 (Cy3) labeled aptamer locking strands were used to form the lock. In principle, when the DNA origami box is closed,
the fluorescence of the Cy3 fluorophore is quenched due to its proximity to the BHQ (Fig. 2 (a)). In the presence of PDGF, When the box is open, the distance between the
BHQ and Cy3 is large enough to observe a strong Cy3 fluorescence (Fig. 2 (c)). Consequently, opening of the structure can be detected by an increase in the Cy3 fluorescence signal.

Fig. 2 Lock Sequences.

Spectrophotometric Measurements

 In all our experiments, the lock is a hybrid of the complete aptamer strand and the complete aptamer locking strand. These strands will heneceforth be refered to as the aptamer strand and the aptamer locking strand respectively. Unless otherwise specified, the mention of a "lock" refers to a hydrid of the complete aptamer and aptamer locking strands, labeled with BHQ and Cy3 respectively. Whenever, labeled strands were used, the aptamer strand was labeled with BHQ and the aptamer locking strand was labeled with Cy3 All the samples were prepared as described under (Lab Book -> Protocols).

 The legend below (Fig. 3) shows all the components mentioned here.

To begin with, the experiments for characterization of the lock were performed independent of the origami. In these experiments, the aptamer strand of the lock was not labeled with BHQ.
Only the aptamer locking strand was labeled with Cy3.

We performed experiments to obtain an optimal fluorophore (Cy3) labeled lock concentration with an optimal signal-to-noise ratio. In all such measurements,
samples containing the fluorophore were excited at 510 nm and emission was recorded at 564 nm, using a spectrophotometer. Fluorescence was measured for 1 nM, 10 nM and 100 nM Cy3 labeled lock concentrations. It was observed that the intensity of fluorescence increased linearly with the increase in Cy3 concentration (Fig. 4). A 10 nM Cy3 labeled lock concentration proved optimal, based on the fluorescence spectra obtained.

Solutions with 10 nM lock concentrations were measured for fluorescence. A control experiment was also designed, in which the aptamer strand of the lock hybrid was unlabeled. In such a control, since the Cy3 fluorescence from the fluorophore on the aptamer locking strand, does not get quenched, a high fluorescence was obtained. In comparison, the lock hybrid with both labels, showed a considerably lower fluorescence signal (Fig. 5). Hence, it was clear that the closed state of the lock is clearly discernible.

We now had the lock and had to work on opening it with its key. Samples of the lock were incubated with PDGF for 24 Hrs [1]. PDGF was always used in a 10 times excess concentration than that of the lock. Control experiments were also designed. The negative control, consisted of the lock. Hence, very minimal signal would be expected with such a control. The positive control sample had the lock with only the aptamer locking strand labeled. In such a control, since the BHQ is absent, a high fluorescence signal would be expected. After repeated trials of such experiments, no significant increase in fluorescence intensity was observed in the presence of PDGF (Fig. 6).

 Since, the use of PDGF to open the lock did not seem to work, the question remained; why did the PDGF key not open the aptamer lock?

- What would you do if you cannot open a lock with your key?

- You would probably try another key!

That is exactly what we did. We used two oligonucleotidic single strands, with sequences complementary to the aptamer strand and the aptamer locking strand, which we call blockers (Fig. 7). Blocker 1 and blocker 2 are complementary to the aptamer strand and the aptamer locking strand respectively. One may consider blockers as better keys because their interaction with the lock is guaranteed due to their sequence complementarity.

Fig. 7 Blocker sequences can open the lock.

Experiments were hence also designed, including the blockers. The following samples were prepared, to serve as the experiments and the controls.

- Lock
- Lock - aptamer strand without BHQ, aptamer locking strand with Cy3
- Lock - aptamer strand without BHQ, aptamer locking strand with Cy3; with PDGF
- Lock; with PDGF
- Lock; with blocker 1
- Lock; with blocker 2
- Lock; with both blockers, blocker1:blocker2 = 10:1
- Lock; with both blockers, blocker2:blocker1 = 10:1
- Lock; with both blockers, blocker1:blocker2 = 10:1, sample annealed before incubation
- Lock; with both blockers, blocker2:blocker1 = 10:1, sample annealed before incubation

PDGF was always used in a 10 times excess concentration than that of the lock. All the samples were incubated at room temperature for 24 Hrs. The results of this experiment are presented in Fig. 8.

 From the results obtained, it was observed hat the blockers work better than PDGF at opening the lock hybrid. Blocker 1 was found to be more efficient than blocker 2 as expected, since Blocker 1 is complementary to the aptamer strand over a longer length than Blocker 2 to the aptamer locking strand.
Gel Shift Assays

Our lock and key system was adapted from previously published results [1], the only variable being that both the aptamer strand and the aptamer locking strand were labeled. Hence, when our spectrophotometric measurements did not give us affirmative results, our first concern was whether the presence of the fluorophores was causing steric hinderences that prevented the key from binding to the lock. To clarify this concern, we ran a gel shift experiment (Fig. 8). The samples for each lane of the gel are as described below.

- Lock
- Lock; PDGF
- Aptamer strand with BHQ
- Aptamer strand with BHQ; with PDGF
- Aptamer locking strand with Cy3
- Ladder
- Lock - aptamer strand without BHQ, aptamer locking strand without Cy3
- Lock - aptamer strand without BHQ, aptamer locking strand without Cy3; PDGF
- Aptamer strand without BHQ
- Aptamer strand without BHQ; PDGF

All the samples were prepared as described in (reference link). All samples were incubated at room temperature for 24 hours, before being run on the gel. A 20 bp DNA ladder was used. A shift was clearly observed everytime PDGF was present with the aptamer strand or the lock hybrid. More importantly, it was observed that labeling the strands did not affect the binding of PDGF to the aptamer.

As the next step, to reaffirm the specificity of PDGF to the aptamer strand, another gel experiment was run. The gel is shown in Fig. 9. The samples for each lane of the gel are as described below.

- Aptamer locking strand with Cy3; PDGF
- Aptamer locking strand with Cy3
- Aptamer locking strand
- Aptamer strand with BHQ
- Aptamer strand
- Lock
- Lock - aptamer strand without BHQ, aptamer locking strand with Cy3
- Lock - aptamer strand without BHQ, aptamer locking strand with Cy3; with PDGF
- Aptamer strand without BHQ, incubated with PDGF. Aptamer Locking strand with Cy3 added after incubation period.
- Ladder
- Lock; PDGF
- Unspecific ds-DNA, one strand labeled with Cy3
- Unspecific short ds-DNA, one strand labeled with Cy3; PDGF
- Lock,aptamer strand without BHQ, aptamer locking strand with Cy3; blocker 1 and blocker 2

All the samples were prepared as described in (reference link). All samples were incubated at room temperature for 24 hours, before being run on the gel. A 20 bp DNA ladder was used. The gel was scanned in a gel scanner for the presence of bands rich in Cy3. A Cy3 band is seen in every lane that has DNA labeled with Cy3. In all the wells with PDGF – 2,9, 10,12 and 14, binding is observed, because Cy3 is observed in the wells. In well 9, no separate Cy3 band is observed except in the well. This suggests that the two strands of the lock hybrid do not separate when PDGF binds to the aptamer. In lanes 2 and10, a separate Cy3 band is observed, way below. This is easily explained for well 10, because, in this sample, the aptamer and PDGF were incubated for 24 hours and the complementary Cy3 labeled strand was added later. Ideally in lane 2, we should have seen just the Cy3 band in the gel with no Cy3 remanants in the well, since we expect PDGF to bind specifically only with the aptamer strand. This is however not the case. Similarly, in lane 14, we would expect just the Cy3 band in the gel with no Cy3 remanants in the well. However, we again notice unspecific binding here. These observations suggest that PDGF do not specifically bind only to the aptamer. However, in the last lane with the blockers, we observe to faint bands. One of these bands corresponds to the single stranded complementary strand. The other band corresponds to the complementary strand-blocker2 hybrid. This suggests that when the blockers are used, the lock does open.

To confer specificity to the opening of our DNA Origami Box, we wanted to use an aptamer based lock and key system. The specificity of aptamer-protein binding reactions, opens up numerous possibilities for using the system in biological scenarios. Our lock and key mechanism was adapted from previously established results. However, the system did not work as well as expected. It was hard to ascertain that the lock was definitely open. Multiple spectroscopic measurements were run with different parametric conditions and different lock and key concentrations. The end result was however, not successful. To rule out the possibility of hinderances in aptamer-protein binding due to the presence of the fluorophores, gel shift assays were run. It was seen that the presence of the fluorophores did not show results different from when fluorophores were present. To confirm the specificity of PDGF to the aptamer, gel shift assays were run. It was observed that PDGF bound to the unspecific sequences too. Overall, the system did not perform as expected. However, the use of blockers
to open the lock was our temporary fix to the problem.


text:
Minnesota Bundles Up for Twins Home Opener [PHOTOS]
Minnesota Twins fans didn't mind the cold too much. They were at Target Field Monday for the earliest — and maybe the chilliest — Home Opener in club history. Alas, the Twins lost the opener, 4-2 to the Detroit Tigers.
(Photos: Joe Bielawa for Townsquare Media-St. Cloud)

subset: commoncrawl


text:
"Declare His Glory" - An Evening of Worship and Celebration
Hattiesburg, Miss., January 29, 2013 - The Winters School of Music presents "Declare His Glory," an evening of worship and celebration at 7 p.m. on Monday, February 11, 2013, in Smith Auditorium, Thomas Fine Arts Center. The program features the choirs and orchestras of William Carey University, First Baptist Church McComb, and Midway Baptist Church. Admission is free. For more information, call 601-318-6175.
Event Date:
Monday, February 11, 2013 - 7:00am


text:
Yost: Melvin doing 'phenomenal job' as A's skipper
OAKLAND -- Entering Friday night's series opener, there was a bit of symmetry between the opposing managers. Both Royals skipper Ned Yost and A's manager Bob Melvin had racked up 786 career managerial wins over their 11 respective seasons on the bench.
"He's doing a phenomenal job," Yost said of Melvin. "[Twins manager] Ron Gardenhire and I were talking last night and he asked me where we were going. I said, 'Well, we've got to go to Oakland.' He's like, 'Oh man. I hate playing those guys. They never make a mistake. Everything they do is right.' They're just a tough, tough team. [Melvin] probably won't take a lot of credit for that, but he deserves a lot of credit."
The Royals will be the first team to face the A's since they rocked the baseball world on Thursday by sending slugger Yoenis Cespedes to Boston in exchange for ace Jon Lester and outfielder Jonny Gomes in a Trade Deadline deal. Lester is scheduled to make his A's debut against Jason Vargas and Royals on Saturday.
Even though many expect Oakland's league-leading offense to drop off without Cespedes' bat in the lineup, Yost said the A's are poised to make some noise in October.
"Look, with that pitching staff that they've got, you can afford to lose offense," Yost said. "That's what playoff teams are built on -- dynamite staffs, dynamite bullpen."
Alex Espinoza is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Brought to you by the creator of the popular Ultra Voice Changer app
Lenovo Vibe Z smartphone was launched in November 2013. The phone comes with a 5.50-inch touchscreen display with a resolution of 1080 pixels by 1920 pixels at a PPI of 401 pixels per inch.
The Lenovo Vibe Z is powered by 2.2GHz quad-core Qualcomm Snapdragon 800 processor and it comes with 2GB of RAM. The phone packs 16GB of internal storage cannot be expanded. As far as the cameras are concerned, the Lenovo Vibe Z packs a 13-megapixel primary camera on the rear and a 5-megapixel front shooter for selfies.
The Lenovo Vibe Z runs Android 4.3 and is powered by a 3000mAh non removable battery. It measures 149.10 x 77.00 x 7.90 (height x width x thickness) and weigh 145.20 grams.
The Lenovo Vibe Z is a single SIM (GSM) smartphone that accepts a Micro-SIM. Connectivity options include Wi-Fi, GPS, Bluetooth, FM, 3G and 4G. Sensors on the phone include Compass Magnetometer, Proximity sensor, Accelerometer and Ambient light sensor.
How to download Ultra Ringtone Morpher form Lenovo Vibe Z?
- Check the Android version to verify compatibility of Ultra Ringtone Morpher with Lenovo Vibe Z.
Find Android version: go to "Settings" - "About the phone" - "Android version". Make sure Ultra Ringtone Morpher is compatible with Lenovo Vibe Z.
- Click the download button to download Ultra Ringtone Morpher in Lenovo Vibe Z.
- Once the download and installation are complete, find Ultra Ringtone Morpher in your home screen and tap the icon to open it.
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text:
Note: This item is more than 12 years old. Please take the publication date into consideration for any date references.
Print – Plain Text – Permalink
News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
March 14, 2005
Texas Hunting Accidents Drop to Record Low
AUSTIN, Texas – A new report shows Texas hunting accidents in 2004 decreased to the lowest amount since statistical records began in 1966. The number of people injured in hunting accidents in Texas decreased from 44 in 2003 to 29 in 2004, although fatalities increased from two to four during the same period.
More important than the annual dips and peaks, however, is the long-term trend.
"Overall, we've cut accident rates by more than half since the 1960s and 70s," said Steve Hall, Texas Parks and Wildlife Department education branch chief, and author of the latest Texas hunting accident report. Hall attributes part of the steady decrease to mandatory hunter education that began in 1988.
Hall said the significant factors behind most hunting accidents have not changed much in recent years. He believes wearing blaze orange would avoid many accidents. Law violations are common in accident scenarios, including many violations for "failure to take a hunter education course." (Any hunter born on or after Sept. 2, 1971 must pass the course to legally hunt in Texas.)
The primary reason for Texas hunting accidents remains swinging on game outside a safe zone of fire. This happens when a person points a firearm at another hunter while following a moving target, such as a flying game bird. Hunter education teaches people to set up safe zones of fire where a gun can be safely pointed whether the target is moving or stationary.
Careless firearm handling remains another primary factor in many accidents.
"Careless handling incidents almost always involve three factors: pointing a loaded firearm muzzle at yourself or someone else with the safety off and with your finger inside the trigger guard," Hall explained. Hunter education courses teach ways to safely handle firearms, including how to carry them in the field and pass them from one person to another.
Some statistics seem to defy stereotypical expectations. Most accidents do not happen under the influence of alcohol or drugs. Most of the people involved had more than 10 years of hunting experience. Most were in light to open cover with clear visibility in good weather.
Other findings verify what might be expected. Most people involved did not attend a hunter education course or wear any type of hunter orange clothing. Most accidents violated a cardinal rule of hunter safety, were situated in or around a vehicle or stand, and occurred toward dusk and involved fatigue as a factor.
Dove hunting had close to twice the number of accidents (11) as the next highest accident category for 2004, deer hunting (6). This is because hunting birds on the wing involves the greatest risk of swinging on game outside the safe zone of fire.
Last year was the first in which hunters in Texas could purchase a deferral, which postpones the requirement to take hunter education for up to one year.
"We did this to allow more adults to try hunting," Hall said. "You still must be accompanied by a person who has completed hunter education or is exempt. The idea is to encourage hunter recruitment with experienced mentors."
Texas has a national reputation for making access to hunter education convenient and plentiful with more than 4,400 courses offered across the state and at least one in all 254 counties each year. The summer months when school lets out are an ideal time for new hunters to take the course.
Texans have several options available for fulfilling hunter education requirements, including the traditional classroom environment, a home study course and an online course. Texas certifies about 33,000 students annually.
The hunter education course is a minimum 10-hour class that teaches hunting safety, modern and primitive sporting arms, wildlife conservation, outdoor skills and responsibility. When the course is completed, the certification card is good for life and is honored by all states, Mexico, and all Canadian provinces that require hunter education. Proof of certification, which includes the card or the hunter education certification number printed on the hunting license, must be carried at all times while hunting.
Hunters ages 12-16 must either pass the course or be accompanied by a person who is at least 17 or older licensed to hunt in Texas who has had hunter education or is exempt. Hunters younger than age 12 may take the course but they will not be certified and must be accompanied by a person licensed to hunt in Texas who is at least age 17 or older who has had hunter education or is exempt. Accompanied means within normal voice control and preferably within arm's length.
Hunters can purchase a license before becoming certified, but they must carry proof of certification while hunting.
More information about hunter education as well as the schedule of course offerings are available at local TPWD offices, by calling TPWD at (800) 792-1112 ext. 4999.
On the Net:
- http://tpwd.texas.gov/edu/hunted/
- http://tpwd.texas.gov/publications/wildlife_habitat/education/2004_hunting_accidents.pdf
- http://tpwd.texas.gov/edu/hunted/archives.phtml
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text: +-------------------------------------------------------------------------+ | TPWD News Release 20060104b | +-------------------------------------------------------------------------+ | This page contains only plain text, no HTML formatting codes. | | It is not designed for display in a browser but for copying | | and editing in whatever software you use to lay out pages. | | To copy the text into an editing program: | | --Display this page in your browser. | | --Select all. | | --Copy. | | --Paste in a document in your editing program. | | If you have any suggestions for improving these pages, send | | an e-mail to firstname.lastname@example.com and mention Plain Text Pages. | +-------------------------------------------------------------------------+ [ Note: This item is more than 11 years old. Please take the publication date into consideration for any date references. ] [ Media Contact: TPWD News, email@example.com, 512-389-8030 ] Jan. 4, 2006 Lonestar Aquafarms Donates Red Drum for Stocking in Lakes Braunig, Calaveras and Fairfield John Turner, General Partner/Manager of Lonestar Aquafarms, Ltd., a red fish farm outside Palacios in Jackson County, is donating about 30,000 red drum to the Texas Parks and Wildlife Department (TPWD) again this year. The three quarter pound fish, worth between $30,000 and $50,000, will be stocked today in three power plant lakes for recreational fishing. The lakes scheduled to receive the fish are Lake Fairfield outside Fairfield in East Texas, Lake Braunig and Lake Calaveras outside San Antonio. "This donation is very important to TPWD because red drum, a saltwater species, does not reproduce naturally in these freshwater systems and the fishery is maintained only through stocking," said Brian Van Zee, of TPWD Inland Fisheries Division in Waco. "In addition, the donated fish are larger than what is normally stocked so we expect a high rate of survival from these stockings, which could mean better red drum fishing at these lakes in the future." For more information contact John Turner at Lonestar Aquafarms, Ltd. by email at firstname.lastname@example.com or by phone at (361) 972-3240. Lonestar Aquafarms is located at 1014 Jackson County Rd. 477 near Palacios. -30-


text:
Relentless Conference
The Relentless Conference will feature spiritual music and speakers, including Brian Orme and Michael Leyde. Visit www.relentlessgeneration.com or call 801-505-9248 for information.
When • Saturday, Feb. 23, 9 a.m.
Relentless Conference
The Relentless Conference will feature spiritual music and speakers, including Brian Orme and Michael Leyde. Visit www.relentlessgeneration.com or call 801-505-9248 for information.
When • Saturday, Feb. 23, 9 a.m.
Where • Christian Life Center, 2352 E. Highway 193, Layton
Tickets • $45; visit bit.ly/14qNxGI
Interfaith Month Event Hindu Fire Sacrifice Ceremony
Visit the Hindu Temple for a Fire Sacrifice Ceremony as part of Interfaith Month. Visit www.interfaithroundtable.org for information.
When • Saturday, Feb. 23, 11:30 a.m.-1:30 p.m.
Where • India Cultural Center, 1142 W. South Jordan Parkway, South Jordan
Tickets • Free
African Methodist Episcopal Church Founder's Day
African Methodist Episcopal Church will celebrate its founder's day. Choirs, clergy and congregations from Hill Top Methodist Church Choir, Trinity AME Community Church Choir, Calvary Baptist Church, Ebenezer Church of God in Christ and Embry Chapel AME Church will attend.
When • Sunday, Feb. 24, 3:30 p.m.
Where • Trinity AME Church, 239 E. 600 South, Salt Lake City
Tickets • Free
Purim Festival
Chabad Lubavitch of Utah will celebrate the Jewish festival of Purim, which commemorates the salvation of the Jewish people in ancient Persia. Purim observances include a reading of the megillah and a Purim feast. Visit www.jewishutah.com/templates/articlecco_cdo/aid/2131820/jewish/Purimania.htm for information.
When • Saturday, Feb. 23 at 7 p.m., Sunday, Feb. 24, 5 p.m.
Where • Chabad Lubavitch of Utah, 1760 S. 1100 East, Salt Lake City
Interfaith Month Event A Climate for Change
Utah Interfaith Power & Light will hold an open discussion about real solutions to climate change. There will be presentations by the Rev. Charles Robinson, Pastor Jeffrey Louden, and Park City Mayor Dana Williams, which will be followed by a group discussion. Visit www.interfaithroundtable.org for information.
When • Tuesday, Feb. 26, 7-8 p.m.
Where • St. Luke's Episcopal Church, 4595 N. Silver Springs Drive, Park City
Tickets • Free
Gordon B. Hinckley Endowment for British Studies Julia Lupton
Julia Lupton, a specialist in medieval and renaissance literature, will present her "Five Things in Romeo and Juliet" as part of the Gordon B. Hinckley Lecture in British Studies.
When • Wednesday, Feb. 27, 2 p.m.
Where • University of Utah Fine Arts Auditorium, 410 Campus Center Drive, Salt Lake City
Tickets • Free
First Baptist Church Outreach
First Baptist Church will hold its Outreach meeting for those questioning Mormonism. The Outreach Committee will show the series on Transitions: The Mormon Migration from Religion to Relationship.
When • Saturday, March 2, 9 a.m.-noon
Where • First Baptist Church of Provo, 1144 W. Columbia Lane, Provo
Tickets • Free
Interfaith Month Event A Family Promise
Youths from all faith traditions are invited to participate in this service project to benefit the homeless guest families of the Family Promise interfaith shelter. RSVP at email@example.com for information.
When • Saturday, March 2, 10 a.m.-noon
Where • Family Promise Salt Lake Day Center, 814 W. 800 South, Salt Lake City
Tickets • Free


text:
The pirate site plans to ignore the lawsuits from Elsevier and the American Chemical Society.
Top 7 in Ecology
December 6, 2011|
A snapshot of the most highly ranked articles in ecology, from Faculty of 1000
December 6, 2011|
A snapshot of the most highly ranked articles in ecology, from Faculty of 1000
December 5, 2011|
A traditional drug to treat insomnia shows surprising promise in awaking minimally conscious patients.
December 2, 2011|
Poet Katherine Larson explores the intersection of art and science through the lyrical works "Metamorphosis" and "Crypsis and Mimicry."
December 2, 2011|
The Dutch Psychologist who's made headlines recently for a massive case of scientific fraud has a Science paper retracted.
December 1, 2011
Meet some of the people featured in the November/December 2011 issue of The Scientist.
December 1, 2011|
US salaries are starting to recover after last year's survey recorded the first-ever drop.
December 1, 2011|
A poet finds artistic inspiration in her work as a scientist and new perceptions in the lines and linkages of her art.
December 1, 2011|
Genomicist Mark Stoeckle and three high school students have taken do-it-yourself science to a new level.
December 1, 2011|
The story of a group of high school students who, with the help of a Rockefeller University researcher, conducted and published studies on the biological provenance of sushi and teas from around New York City.
November 30, 2011|
A new public science project asks people at home to match whale songs in hopes of better understanding their language.


text:
DETROIT - Bowling alleys are great fun for the entire family. Whether you're looking to join a Detroit league, watch the latest game, partake in some karaoke or find some after-school activities for children, there are plenty of bowling alleys in the Detroit area to choose from.
Voters choose what they believe are the best Detroit bowling alleys in this year's Vote 4 The Best contest.
VOTE 4 THE BEST: 2012 winners of best bowling alleys in Detroit
Woodland Lanes
Celebrating over 35 years of business in Livonia is Woodland Lanes, which tops the list of best bowling alleys across Metro Detroit.
Woodland Lanes says it is Livonia's only family owned and operated bowling center. They offer 32 lanes, two remodeled lounges, bumper bowling, birthday party celebrations and more.
For more information and directions to Woodland Lanes, click here.
5 Star Lanes
Located in Sterling Heights, 5-Star Lanes says it offers a clean, comfortable, smoke-free and family friendly atmosphere for all to enjoy. With 50 bowling lanes, remodeled luxury tables and 37" scoring monitors, 5-Star Lanes also offers a pro shop for professional bowlers.
"They are very friendly and accommodating," said Grace. "The lanes are very well kept up."
Click here to learn how to get to 5-Star Lanes.
Wonderland Lanes
Wonderland Lanes in Walled Lake.
Wonderland Lanes says it is available for a variety of events, including private birthday parties to larger corporate events. The bowling alley also provides Glow Bowling, catered buffets, live entertainment and hosts profitable fundraisers for several charities.
They go above and beyond to make everyone feel welcome," said Holly on our contest page. "Very friendly environment, great prices, overall best place to hang out."
You can find directions and more information about Wonderland Lanes by clicking here.
Curious to see which other bowling alleys in Detroit made the list? Click here to learn more.
Copyright 2012 by ClickOnDetroit.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Off-season. What's an off-season? I hardly remember what a true off-season is anymore because I race nearly year round. I can tell you, though, that I am anxiously looking forward to a few weeks off in February between the end of 'cross season and the beginning of road racing.
Although in recent years I haven't had a true "off-seasons", I can tell you from past experience that the off-season is a time for reflection, a time to look back on the triumphs and disappointments from the past season. What went right/wrong in training? Were you happy with your race results? Could your nutrition have been handled better? Did you make the best out of every outcome – good or bad? What changes need to be made to make the coming season even better? Now is the time to consider all that went right and wrong in every facet of your cycling "life" to help prepare for a more successful 2012.
As you mull over 2011 and plan for 2012, think about how, when, where you're going to give yourself some down time, too. Put the bike away for a few weeks. Walk. Hike. Run. Ski. Hit the gym. Do yoga or try pilates for the first time. Do all the things that you don't get a chance to do during the season when all focus is on the bike.
In the days when I did have an off-season, I spent quite a bit of time in the gym working on my core and overall body strength and stability with Cross Fit. Unless a person is working on muscle imbalances or has a very specific focus, I believe that no cyclist needs to use a single static machine to build strength, power or endurance. Cycling is dynamic. Sure we are stationary on the saddle, but we are always in motion. It's the coordination of muscles between the upper body, back and legs that power our movement on the bike, so why single out just one muscle? In one shot Cross Fit-type exercises incorporate almost every major muscle group into each different exercise, which improves stability, strength, power and endurance across multiple joints, not just a single muscle.
Don't just toss your training program out the door. Eat the cookies you usually vehemently shake your head at in fear of gaining an extra pound. Have two (or three) beers instead of just one. Enjoy a Thanksgiving feast without guilt. Cut yourself some slack…for a little while anyway. Let your body recover from the strict limitations and stress that it deals with for five, six, seven months out of the year.
After a few weeks or so of unregimented "training", slowly work yourself back into a casual training schedule. Don't jump into intensity right away. Ride slow, long miles. Continue to mix in other activities as well. Reconsider drinking that third beer or eating that fourth cookie. As the weeks and months tick by, tighten the focus on your training and nutrition so when you line up for the first race of the year you are as best prepared as possible. That doesn't mean you should be at your fittest, because few people need to be flying in March, but you should be on target to reach your 2012 goals.
If you want to bring out your wild and crazy side, try cyclocross. My only warning is that it is addictive. I know from experience. It's why I haven't had an off-season in several years. But, it's also why in December when it's cold and dreary outside I am happy to be on my bike. I can race instead of train and have a lot of fun doing it. Plus, I like getting muddy. Maybe you will, too.


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Cards honor the '64 champs
Mon, 26 May 2014 21:46:25 GMT —
The St. Louis Cardinals have honored Bob Gibson and other members of their 1964 team that beat the New York Yankees in the World Series.
There was a ceremony at Busch Stadium on Monday before the Cardinals hosted the Yankees in the opener of an interleague series. More than a dozen members of that championship team were on hand.
Gibson threw the ceremonial first pitch from halfway between the plate and the mound. Longtime catcher Tim McCarver was on the receiving end.
Gibson was the winning pitcher in Game 7 of the 1964 World Series. Gibson, outfielder Lou Brock and Red Schoendienst, a coach on that team, are in the Hall of Fame.


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Diane Cooke discovers some wonderful things on sale at a shop run by taxidermy enthusiast Norman Wright
TAG antlers, stuffed crows and baby pigs in jars are big business in Accrington.
Strange as it may sound, natural history artefacts are very de rigeur among interior design enthusiasts. It seems antlers and stuffed deer heads are the art forms to decorate one's sitting room walls these days, according to style bible Marie Claire, which has twice featured unusual specimens from Weird and Wonderful on the town's Whalley Street.
The shop is celebrating its first birthday and its founder Norman Wright, 23, from Clitheroe, is planning to register the shop as a natural history museum.
Norman has transformed the dilapidated old building using skills he acquired whilst studying for a 3D design new practice course at Loughborough University which taught him everything from blacksmithing to carpentry.
His interest in all things...erm...dead stems from his visits to museums and castles as a child with his grandma. "I've always had an affinity with old things. "Taxidermy is an art form which is really gaining in popularity. Some see it as preserving life. It's a very skilled job."
Norman started collecting things in his bedroom and his interest progressed into an online store. His customers range from barristers to six-year-old boys with a fascination for fossils.
A set of antlers can cost anything from £25 to £700 and Norman is keen to make it clear that all his products are ethically-sourced without impacting on the environment. "We don't go out shooting deer at weekends. They come mainly from Scottish wildlife reserves and country home estates and are the result of a culling operation."
Likewise the taxidermy crows, magpies and other animals are the result of pest control or roadkill.
But Norman can't quite get to grips with the trend for baby pigs preserved in jars of formalin: "They come from farms or vets and may have been still born. But girls love them and want them for their rooms."
And at a cost of £50 to £100 some would say that's plain freaky.
His osteology collection includes human bones, skulls and skeletons. Some are finds from archaeological excavations others are ex-medical school specimens. "They use plastic ones these days because they're easier to come by and cheaper."
Tropical butterflies, particularly large and colourful ones from Africa or Madagascar literally fly out of the shop and online. At around £28 each, Norman sells out every week.
"I can also source rarer antiques, a giraffe skull, for example," says our intrepid explorer.
"When I was at college I just wanted to paint pretty pictures, but I followed my feet and it brought me here. Accrington is an unusual place for such a shop, but the town could do with more entrepreneurs."
The large retail space is shared with the North West Barber Co. Haircutting and taxidermy – now that is Weird and Wonderful.


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NEW YORK ( TheStreet) -- Investors who are looking for a recovery play may have an excellent opportunity to scoop up shares of Bank of America ( BAC) on the cheap, as the " Fiscal Cliff" drama continues in Washington. As nearly all of our readers know by now, the federal tax cuts extended by President Obama as part of a deal with Republicans in Congress in August 2011 will expire at the end of the year, without a new deal. Along with the tax increases, the Budget Control Act of 2011 requires a large cut in federal spending, in an effort to reduce the annual federal budget deficit by $1.2 trillion over 10 years. Many economists believe that "falling off the fiscal cliff" at this stage of a slow economic recovery would cause the U.S. economy to slip back into recession. Guggenheim Securities analyst Marty Mosby on Monday said in a "Tactical Trading Sell" report that Bank of America "is one of the leading candidates for a significant correction if the pressure on the U.S. economy from the Fiscal Cliffs begins to build." Mosby actually rates Bank of America a "Buy," with a $12 price target, which would represent 21% upside, however, the rating and the target have 12-month outlooks, while Mosby believes "BAC could trade below $8 over the next three months if it becomes apparent that the U.S. economy is about to be pushed over several of the upcoming Fiscal Cliffs." The analyst's short-term trading range for the next three months for Bank of America is from $7 to $8 a share, "based on a 60% price to current tangible book value multiple. BAC currently trades at 73% of current tangible book value." Mosby said that "the risks to this tactical trading call are twofold: Washington politicians work together to craft the 'Grand Bargain,' avoiding the upcoming Fiscal Cliffs, or the economy builds up enough momentum to absorb the unfavorable impacts of higher taxes and spending cuts and still keep growing."
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Manage your account and access personalized content.
Access your cloud dashboard, manage orders, and more.
Oracle Insight uses a proven methodology which is flexible and customized to individual company objectives. Most engagements consists of four steps: Industry Perspective, Discovery, Solution Design, and Solution Presentation
Given the plethora of acquisitions made by Oracle, we want to help you understand how these new capabilities have helped others in your industry. Oracle facilities an in-depth discussion with your executives about industry trends, best practices, vision, strategy, and challenges and roadblocks.
Leveraging established industry frameworks and robust intellectual property, we assess your current business processes and identify the capabilities required to achieve your corporate strategy. We will compare you to industry benchmarks and identify both the qualitative and the quantitative benefits from enabling those capabilities.
The Oracle Insight team will come to a customer's site, and, through a series of discussions, determine which capabilities the customer needs to have within its enterprise to achieve its strategic goals. Then, the team will connect those capabilities with the best solutions for that particular customer. As part of the process, the team reviews software configurations and installations, and recommends methods to help get the most value from the software.
Oracle recommends best practice processes and supporting technology, including a time-to-benefit analysis and implementation plan.
The Insight team works with you to create an executive presentation including supporting information, business benefits, and value drivers, to help you build consensus among colleagues and executive management or secure funding from your board.


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Flavored chewable wormer eliminates and controls roundworms, hookworms, and tapeworms in dogs. Broad-spectrum wormer uses two active ingredients: Pyrantel Pamoate and Praziquantel. You can feed these palatable tablets by hand, or if your dog does not eat it voluntarily, hide it in a small amount of food or in a treat. Each package contains 12 pork liver flavored tablets. Recommended for dogs and puppies 12 weeks of age and older.
Wormer treats and prevents:
Large Dogs (greater than 25 lbs.)
Please click on "More Information" for use information.


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Granted, but the definition of "fun" is provided by a buddhist monk.
I wish I had grades good enough for medical school
Granted, but while in medical school you party too hard and pass out on lab bench, the next morning the class thinks you're a cadaver and begin to practice on you. If you wake up early enough you'll only be missing 1 kidney, if not... good thing you spent so much time studying.
I wish for a cataclysmic event, like a super volcano or a meteor hitting the earth, that will kill half the planet's population.
Granted, but for the first (and only) time in the history of the Earth, everyone in every country actually puts the stupid crap aside and works together, diverting the meteor, rescuing mankind, and ushering in a new era of peace. After killing the guy who wished the meteor up in the first place.
I wish I wasn't so full - this dinner is delicious and I want to finish it!
[22:14] <+Lia> And why is Ruken molesting trees?
[22:14] <@Rukentuts> Because they give me wood.
[22:14] <+Lia> ...
[22:14] <+Lia> worst pun ever
[22:15] * Rukentuts boughs.
Granted! You puked uncontrollably over your dinner. Now you're all hungry again, but your delicious dinner is ruined
I wish I have a delicious dinner.
Granted. it's now covered with your blood, sweat, and tears!
I wish I was a kerjilzilitilion.
Granted, except I don't know what that is so I get it horribly wrong and you come out as a human with an eating disorder
I wish my cup of tea would make itself properly and then bring itself to my desk where it waits for me to drink it.
Granted. But your cup of tea do all that so quietly, you don't notice it's there until it has gone cold
I wish for a cake with no calories.
Granted, but the only way for it to have no calories is for it be invisible.
I wish I notice my cup of tea is here before its gone cold.
Granted, but it's green tea, and not proper herbal tea, or even that silly black tea.
I wish I had an endless glass of warm herbal tea.
Granted, but due to the fact that your glass of tea is endless and you can't seem to help yourself, you consume the tea till you pop like a balloon.
I wish I could get better sleep and had more than 3 hours of decent energy in a day.
Granted, but it's been sitting in your car for a week. Your experience with this week-old coffee is so bad that you never wish to drink coffee again.
I wish my friends and I could skip to the front of lines at theme parks.
Granted, but that means you work at the theme parks, you're at the front of the line but can never ride them.
I wish I could find a decent employee amongst the 12 interviews I have today.
Er... wut? Maybe I just haven't had enough coffee, but I'm having a hard time with that. I think I'm going to go with a generic "Granted, but you get hit by a bus full of trucks immediately afterward and are splattered across the pavement like Wile E Coyote on his worst day"
I wish I knew what Ridesdel wished for
[22:14] <+Lia> And why is Ruken molesting trees?
[22:14] <@Rukentuts> Because they give me wood.
[22:14] <+Lia> ...
[22:14] <+Lia> worst pun ever
[22:15] * Rukentuts boughs.
Granted, you are now a pregnant female.
I wish my guild raided as well as koreans.
Granted - they are all replaced by Koreans, and they kick you for not speaking the language and/or being up to their level of skill.
I wish I knew how knowing what Ridesdel wished for got me pregnant!
[22:14] <+Lia> And why is Ruken molesting trees?
[22:14] <@Rukentuts> Because they give me wood.
[22:14] <+Lia> ...
[22:14] <+Lia> worst pun ever
[22:15] * Rukentuts boughs.
Currently only reading the Funny Pictures Megathread because the rest of the forums is filled with piss, whiners and pissed whiners.


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Retail sales show slow growth in August, says Commerce and NRF
August retail sales showed growth at a time when consumers are still being cautious with discretionary spending, according to data from the United States Department of Commerce and the National Retail Federation.
August retail sales showed growth at a time when consumers are still being cautious with discretionary spending, according to data from the United States Department of Commerce and the National Retail Federation.
Commerce reported that August retail sales at $406.7 billion were up 0.9 percent compared to July and up 4.7 percent annually. This represents the largest monthly gain in six months, according to Commerce data. Total sales for the June through August period were up 4.0 percent annually.
The NRF reported that August retail sales, which exclude autos, gas stations, and restaurants, were up 0.2 percent on a seasonally-adjusted basis from July and up 3.8 percent on an unadjusted basis annually.
"While retailers continue to witness sustained sales growth, consumers remain cautious about their discretionary expenditures," NRF Chief Economist Jack Kleinhenz said in a statement. "Consumers have carried much of the growth during the economic recovery, despite high food and gas costs. Though the economy isn't backsliding, growth continues to be a sore point."
On top of flattish economic growth, the possibility of an East and Gulf Coast ports strike, due to an ongoing stalemate between the International Longshoremen Association and the United States Maritime Alliance over a new labor contract remains a possibility, with a September 30 deadline looming. The NRF and other concerns have stated that should a strike occur it could throw a wrench in supply chain and logistics planning for retailers with holiday shopping season quickly approaching.
There are other concerns, too, on the economic front in the form of high unemployment, slowing manufacturing growth, lower consumer confidence, and low housing prices, among others.
Earlier this week, UPS CEO Scott Davis said the nation's economy is being held back by its debt load and the uncertainty of fiscal policy and called on leaders in Washington, D.C., to prepare a bipartisan debt reduction plan by January.
As LM has reported, retail sales largely show slow and incremental growth, while continued growth is needed over a longer period, as consumer spending accounts for roughly 70 percent of U.S. economic activity. And while retail growth is relatively slow still, signals remain intact that the economy is showing some signs of recovery, with consumer confidence on the upswing to a large degree declines in gasoline prices over the last two months.
The continuing trend of slight or flat sequential retail sales increases remains largely intact due to fairly even retail spending at a time when retailers remain cautious on the inventory planning side and postponing commitments until the until the economic outlook becomes clearer, while they are risking stock outages by having very lean inventories.
Charles W. "Chuck" Clowdis, Jr., Managing Director-Transportation Advisory Services, at IHS Global Insight, explained that depending upon which indicators you follow, this year's Back-to-School Season was less robust than expected.
"If school clothing and supplies purchases were down, there would still have to be other commodities that slowed in August," he said. "With unemployment still hovering over 8 percent and real unemployment well in to the double digits, workers appear to be paying-down their debt and attempting to save more. We hope cautious optimism is emerging…even in a very small, albeit, positive direction."
About the AuthorJeff Berman, Group News Editor Jeff Berman is Group News Editor for Logistics Management, Modern Materials Handling, and Supply Chain Management Review. Jeff works and lives in Cape Elizabeth, Maine, where he covers all aspects of the supply chain, logistics, freight transportation, and materials handling sectors on a daily basis. Contact Jeff Berman
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Article TopicsDepartment of Commerce · National Retail Federation · Retail · Retail Sales ·
Improving 3PL Management: Glanbia Adds Muscle to Logistics Why Retail Supply Chain Transformations Fail - and how to get it right View More From this Issue


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TROWBRIDGE snooker star Stephen Lee is determined to press ahead with his revitalised career after the shadow of match-fixing allegations against him was lifted this week.
Lee, 37, learned he will not face criminal proceedings over the allegations made in 2010, for which he was arrested by West Midlands Police as part of an investigation into suspicious betting patterns.
The inquiry was conducted jointly by the police and the Gambling Commission but a World Professional Billiards and Snooker Association (WPBSA) statement this week confirmed that no charges were being brought against the Wiltshire man.
Lee, who was only made aware of the announcement by the sport's governing body while in Hong Kong while on his way home after a series of tournaments in China on Tuesday, told the Wiltshire Times he would be taking legal advice over his options in the wake of the announcement.
But having seen his career head on a significant upwards curve in the last 12 months – he was ranked sixth in the latest world standings – the Trowbridge player is focussing on making the headlines with his fine form on the baize.
"It's been great news and I'd just like to say it's been a tough couple of years,'' he said.
"Back then, I was in a bad place. I'm glad rather than relieved because I hadn't done anything. It's all happened a bit quickly (this week), but I've had good support from people and I'm looking forward now.''
Lee was the form player in the latter half of last season, winning his first ranking title in six years when he clinched the PTC Grand Finals in Ireland in March.
And he added another prize to his collection last week when he won the second Asian Players Tour Championship event in China, briefly returning home on Wednesday before he jetted out to the Gdynia Open title in Poland, where he was facing world number 26 Andrew Higginson in today's first round.
He added: "Sport is about how strong your mind is – if you are feeling good mentally you can do well.
"It was nice to win in China – it makes a long trip worthwhile.
"I'm feeling OK and enjoying it.''


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PEORIA, Ariz. -- The Padres are down to 36 players afterreassigning shortstop Manny Alexander, catcher Luke Carlin andthird baseman Royce Huffman to minor-league camp on Sunday.
General manager Kevin Towers expects all three to start theseason at Triple-A Portland.
Now comes the tough part, said Towers, as the Padres prepare to make their final cuts. Not counting pitcher Shawn Estes and catcher Todd Greene -- who are expected to start the year on the disabled list -- nine more cuts remain.
"You start getting down to the last week and get to guys who feel they have a legitimate chance of making the club," Towers said.
Two players with an inside track are relievers Mike Thompson and Doug Brocail.
Both Towers and manager Bud Black have been singing Thompson'spraises. Brocail, who is guaranteed $500,000, has a 2.89 ERA in theCactus League.
Black and Towers also said they expect to see reliever Heath Bell on the 25-man roster.
That leaves Kevin Cameron, Justin Germano, and Andrew Brown vying for the seventh bullpen spot. Towers also said the final bench spot will either go to Todd Walker, Paul McAnulty or Oscar Robles.
Walker, who is hitting .225 this spring, will earn $3.95 million this season, but only would be owed $987,500 if the team cuts him before March 28.
Normally, Walker would be a valuable trade piece, but he is likely harder to move because of his high salary and an abundance of left-handed hitters on the market.
McAnulty, who has been slowed by a knee injury, is a good outfield option and is hitting .353. Robles, who is hitting .281, would give the team another infielder.
"We have a good idea of the nucleus of our team," Towers said. "We have good options for the last spot."
Bochy returns to Peoria
Former Padres manager Bruce Bochy was given a warm welcome inhis return to Peoria Stadium on Sunday. The new manager of the San Francisco Giants received a standing ovation from Padres fans as hewalked into the stadium before the game.
"No, no (it's not strange)," Bochy said of facing the Padres. "It's behind us. I have great memories there and have tremendous respect for those players I had, but I've moved on and am happy wearing this uniform."
After the game, Bochy left for Melbourne, Fla., to attend thefuneral of his mother Melrose Bochy, 78, who died Friday after a10-year battle with Alzheimer's disease.
Towers all right
Towers was in some pain but good spirits after a foul ball hit his face during Saturday's game in Maryvale, Ariz. The ball got through the netting behind home plate and hit Towers, who was turned sideways.
He had a CT scan at Arrowhead Hospital in Glendale, Ariz., and was treated for a slight concussion, fractured nose and chipped teeth before being released.
Considering what could have happened, Towers felt lucky to only have a fat lip.
"I'll take that any day," Towers said. "All I saw was blood. I never saw it coming. It was quick. … the first 30 seconds wondering where you were at or what happened."
Et cetera
OF Mike Cameron was removed as a precaution after a single inthe second inning of the Padres' 10-7 win over the Giants at PeoriaStadium. Manager Bud Black said Cameron "felt a little tightness inthe back of his knee." … RHP Chris Young threw 103 pitches in aminor-league game. Young threw 5 2/3 innings, allowing four earnedruns on four hits and four walks … SS Khalil Greene hit his fifthhome run of the spring against the Giants. 1B Adrian Gonzalez alsohomered. The Padres lead all of baseball this spring with 38homers.


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- Versa-Handle System - Are you bottom fishing or trolling? Are you looking for power or speed? Penn's Versa-Handle System allows the angler to choose how long the handle should be in less than a minute; tools are included with each reel. Assemble the reel in the long position for more power; assemble in the short position for more speed, your choice.
- Line Capacity Rings eliminate the question of how much line you have left when fighting a fish. The three lines on the spool flange let you know when you have 1/3rd, 2/3rd, or a full spool of line. Also if you respool often these lines give you a benchmark for backing your superlines with monofilament which will help eliminate wasted time and line.
- Switchblade Harness Lugs give you all the benefits of traditional lugs without the risk of grabbing loose line and potentially breaking off fish. When the lugs are not in use they remain flush with the reel frame, when you need them they easily pop up with the tip of your finger. The other benefit of the proprietary Switchblade harness lugs is basic ergonomics. Let�s face it, harness lugs can be uncomfortable when you are palming the reel on the cast or retrieve. If you don�t plan to use the lugs then stow them in the down position and you have one of the most ergonomic reels on the market. Included on 50 & 60 sizes only.
Penn SQL30LD Squall Lever Drag Reel
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Football: Shortwood United and Yate Town share the spoils
11:27am Wednesday 22nd January 2014
By Rob Iles
11:27am Wednesday 22nd January 2014
By Rob Iles
YATE Town survived a late Shortwood United onslaught to earn a good point at a soggy Meadowbank on Tuesday night.
Shortwood increased the pressure in the final 25 minutes as they looked to stretch their winning run to seven games, but the Bluebells have now only lost once in their last eight games after defending heroically at times in the heavy rain.
The closest Shortwood came to a winner came in the 65th minute when Jake Parrott's free kick was headed against the underside of the bar by fellow substitute Kevin Slack and Sam Avery could not bundle the ball in, allowing Mitch Tippins to clear off the line.
Adam Mann, making his final appearance for Shortwood before moving to Conference North side Gloucester City, was determined to sign off in style and looked likely to score three minutes later when he showed a great turn of pace to surge through the middle of the Yate defence, but goalkeeper Martin Horsell saved well with his legs after racing off his line.
Mann was never far away from the action, getting booked for a late challenge on Joe Chandler before making space for a shot from the edge of the box, which Horsell managed to get his body behind after seeing it late.
In five minutes of stoppage time, a combination of Tippins and Horsell somehow kept out Avery's header following Slack's long throw, Duncan Culley shot into the side netting on the turn and Tippins came to the rescue again when he blocked James Coates' header on the line after a dangerous Mann corner.
While Shortwood finished strongly, Yate arguably shaded the first hour and were unfortunate to find goalkeeper Tom King in fine form.
After Shortwood failed to clear a corner properly in the 13th minute, Joe Chandler picked up the ball on the left hand side of the box and King had to be alert to tip his curling shot away from the top corner.
Shortwood then almost caught Yate on the break one minute later as Mann skipped past Tippins down the left and his cross was prodded wide by Ross Langworthy under pressure.
Ross Staley's corner looked like it might go all the way in until King clawed it away from goal and the ex-Bristol Rovers went close again with a deliberately audacious attempt from 35 yards that flew inches over the bar.
A delicious through ball by Nick Hancock with the outside of his boot presented Langworthy with a great chance at the other end but the striker had more time than he thought, chesting down before getting off a quick shot with his left foot that went harmlessly wide.
Yate made a bright start to the second half and when King failed to get much distance on his goal kick, Jake Cox headed the ball into the path of Lewis Haldane, who hit a fierce first-time shot with his left foot that required the goalkeeper to be at full stretch to tip over.
Cox then cut in and had a well-struck 30-yard effort pushed away by King, while Staley fired wide from similar range.
Shortwood United: King, Avery, Brown, Thomas, Coates (c), Richards, Hancock (Parrott, 53), Price (Slack, 63), Langworthy (Culley, 79), Mann, Cant. Subs not used: Sykes, Herbert.
Yate Town: Horsell, Cox, Tippins, Chandler, Harrison, Abraham, Harmer, Bryant (c), Clifford, Haldane (Jackson, 69), Staley (Kamara, 69). Subs not used: Meaker, Dunn, Cousins.
Ref: Steve Oakey.
Att: 99.
Star men: Adam Mann (Shortwood), Mitch Tippins (Yate).
Shortwood visit Bridgwater Town on Saturday, while Yate Town are at home to bottom side Fleet Town.
© Copyright 2001-2017 Newsquest Media Group


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Get your free credit score
What's a good credit score?
By Jean Chatzky
Get your free credit score
If you're thinking about buying a house or a car, your credit score is a very important number.
The interest rate you'll pay for the money you borrow will be determined, in large part, by this three-digit number that's generated from the information in your credit report.
Most lenders have carved-in-stone rules about handing out the best terms, and those rules almost always place a major emphasis on your credit score. If their best rates are offered to borrowers with a score of 700 or higher and yours is a 698, those two points could cost you thousands of dollars.
According to MyFICO.com, the consumer website of popular scoring model FICO, the interest rate difference between those two scores is about one-third of a percentage point.
CHECK YOUR CREDIT SCORE: Monitor your credit score and learn how to build your credit at myBankrate.
On a $165,000 30-year fixed-rate mortgage, that difference could cost you more than $13,378 in interest charges, assuming a 4.5 percent interest rate with a 700 credit score and a 4.875 percent rate on a 698 score. Fall below a 660 and the rate goes up even more, if you can even get approved for a mortgage at all.
Keep in mind that these are averages. Most lenders today practice tiered pricing, with interest rates rising as scores go down. Each lender chooses its own "break points" between tiers. Lender A may bump up the interest rate if a score falls below 700, while Lender B doesn't charge higher rates until the score is 690 or below. So if you stick with one lender, and that lender's break point is 700, raising your score from 698 to 701 can be vital.
Boost your credit score by consolidating debt into a personal loan - Find the Lowest Personal Loan Rates
This underscores the importance of not only doing all you can to improve your score, but shopping thoroughly when looking for a mortgage. From the perspective of a mortgage broker, who can choose among a sea of many lenders, there are no sharp break points. Consumers should do what a good broker does -- look for a lender that offers the best rate for a specific score.
But that's jumping ahead of ourselves. First things first: You can take steps to improve your credit score. The number of variables that play into an individual score make it impossible to say that one particular action will increase a given score by a certain number of points. But there are some good guidelines.
"The key to having the best FICO score possible is following three rules," says Jeffrey Scott, spokesman for FICO. "Pay all your bills on time, every time, keep your credit card balances low and only open new credit when you need it."
That's good advice, to be sure, but these actions take a long time. What if you're house hunting and you just need a few extra points to bump you over the line to the great rates?
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Kasturba Medical College (KMC) was the first college in the private sector to be established and ranks among the top ten medical colleges in the country today. Kasturba Medical College (KMC), Manipal was established on June 30, 1953.KMC is recognized by the Medical Council of India, General Medical Council of Great Britain, the Malaysian Medical Council and Australian Medical Council.
Bachelor of Medicine & Bachelor of Surgery (MBBS)
Offered at KMC, Manipal and Mangalore Campuses
Doctor of Medicine (MD)/Doctor of Surgery (MS)/
PG Medical Diploma
|Manipal Campus
|Mangalore Campus
|MD Anaesthesiology
|MD Anatomy
|MD Biochemistry
|MD Community Medicine
|MD Dermatology
|MD Forensic Medicine
|MD General Medicine
|MD Hospital Administration
|MD Microbiology
|MD Paediatrics
|MD Pathology
|MD Pharmacology
|MD Physiology
|MD Psychiatry
|MD Radio-diagnosis
|MD Radio-therapy
|MS General Surgery
|MS Obstetrics & Gynaecology
|MS Opthalmology
|MS Orthopaedics Surgery
|MS Otorhinolaryngology
|PG Diploma Anaesthesiology
|PG Diploma Child Health
|PG Diploma Clinical Pathology
|PG Diploma Dermatology
|PG Diploma Obstetrics & Gynaecology
|PG Diploma Opthalmology
|PG Diploma Orthopaedics
|PG Diploma Otorhinolaryngology
|PG Diploma Psychiatry
|PG Diploma Radio-diagnosis
|Manipal Campus
|Mangalore Campus
|MSC Medical Anatomy
|MSC Medical Biochemistry
|MSC Medical Microbiology
|MSC Medical Pharmacology
|MSC Medical Physiology
|MSC Clinical Embryology
|MSC Yoga Therapy
Offered at KMC, Manipal Campus
Offered at KMC, Manipal Campus
Offered at KMC, Manipal Campus
DM Cardiology
DM Neurology
Offered at KMC, Manipal Campus
MCh Cardiothoracic Surgery
MCh Neuro Surgery
MCh Paediatric Surgery
MCh Urology
The Health Sciences Library is one of the best libraries in Asia which provides services like E- Learning Centre , Reference Service, Current Awareness Service, Audio-Video Viewing, Internet Access Wi-Fi, DELNET Online..and many more
There are fully equipped laboratories attached to all the departments of KMC which helps the students to develop psychomotor skills which are very essential for the effective practice of medicine.
The Medical Simulation Centre of Manipal University is first of its kind in a private Indian University; it is a new concept in the field of medical education to provide learning by close to realistic clinical experiences.
The anatomy museum at KMC, Manipal is one of the best museums in Asia. It has more than 1000 odd dissected specimens of the human body- adult, foetus and other animals.
KMC is involved in research in different fields of medical sciences. The faculties as well as students are involved into such research activities.
|Journals and Publications
|Seminars / Workshops
|Books Published
|Research Projects
|Clinical Trials
The college definitely is more than an academic abode. The myriad of guest lectures, clinical exposure and extracurricular activities makes for one of the best curriculums in the country. With amazing infrastructure and a dedicated faculty, KMC Manipal has stood beyond my expectations. This is where lives are nurtured.
Sutirtha Ray,
7th Sem
KMC is a melting pot of diverse cultures and filled with rich learning experiences. It is a place to healthy place to blossom academically, professionally and socially.
Dr Steve Serrao,
1996 batch


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Happy Women T-Shirts are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Happy Women T-Shirt for a special occasion, give a Printed Happy Women T-Shirt as a present or need to represent with a funny Happy Tee during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Happy Women T-Shirt for you! Even if it turns out you can't find the right Happy Tshirt with the perfect design for your mother, father or children; Idakoos offers all of its men's women's and children's Happy Tshirts as Custom Happy Women T-Shirts. Personalize any Happy Women T-Shirt the way you want to ensure the perfect gift.
Showing 1 - 24 of 68 Women T-Shirts


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New Statue of the Half-Life Hero...
Gaming Heads presents their latest licensed Valve video game statue: Gordon Freeman, the hero of the Half-Life series. Measuring approximately 20 inches tall, including the base (1/4 scale), Gordon comes in both a standard edition with his trademark crowbar ($319.99 and limited to 1000 pieces) and an exclusive edition packing an additional switch out weapon, the MP-7 ($339.99 and limited to 500 pieces). Both versions feature Gordon gripping Bugbait in his right hand.
Cast in high quality poly-stone, the statue is hand finished and hand painted to exacting standards. Pre-orders just went live at gamingheads.com.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


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Eurostars Lex4
C/ Buenos Aires 49-51, L'Hospitalet De Llobregat, 08902
Price FromView Rooms
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About the hotel
Located on the edge of Barcelona, but very near important business and commercial areas of the city, this is a smart and stylish hotel with great access to the airport. The Eurostars Lex is located just outside the centre of Barcelona, but you can get to the heart of the city in 10 minutes by public transport. From this hotel you can explore the pretty Montjüic area of the city, where you can visit the 1992 Olympic site and top museums – MNAC and the Fundacio Tapies.
At the end of a long day's business or tourism in the city, you can relax with a drink in the onsite bar. Eurostars Lex's rooms boast trendy, contemporary decor. They are equipped with a desk, where you can do some work in the evening.
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- Disabled Facilities, Air conditioning in rooms, 24 Hour Reception, Cots available, Smoking allowed in bedrooms, Safety Deposit Box, Hairdryer in each room, Minibar in each room, Telephone In Each Room, Limited Hours Room Service, Limited room service for hot food, Concierge, Laundry/Valet Service, Wake Up Call Available, Lift to all floors
- Leisure
- Gymnasium, [Channels] News, [Channels] Foreign (European), [Channels] Foreign (Other), [Channels] Music
- In Room Entertainment
- TV, Satellite TV
- Parking
- Car Parking Available Offsite
- Accessibility
- Disabled Access Public Areas, Disabled Access Bedrooms, Disabled toilets on ground floor, Wheelchair Access, Wheelchair Access To Reception, Wheelchair Access To Restaurant, Wheelchair Access To Bar, Wheelchair Access To Conference Rooms
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October 28, 2003
Made possible by the generous support of the
Bill & Melinda Gates Foundation.
Lucille Atkin, Director of Margaret Sanger Center International/ Vice President of International Programs, Planned Parenthood of New York City
Nirmal Bista, Director-General of Family Planning Association of Nepal
Kati Marton, journalist, human rights advocate, Board Chair, International Women's Health Coalition
Moderator: Adrienne Germain, President of International Women's Health Coalition
Sheila Platt: Good evening and welcome everyone. I am Sheila Platt. I am a member of the Asia Society and also a social worker and my work in the Philippines and in Pakistan and particularly in Zambia, among other countries, has for many years involved refugees and displaced persons. I saw the beginning of the HIV/AIDS pandemic while living in Zambia in the early 1980s and I have been very aware ever since of the dreadful effect that is happening in Zambia and elsewhere to women's and girls' health and human rights.
The Asia Society is very pleased tonight to host a timely and important program, Securing Women's and Girls' Health in South Asia: Challenges for Global Policy. The panelists will discuss the critical challenges that lie ahead in securing reproductive health rights for women and girls in South Asia. They will in particular look at the impact of HIV/AIDS on women and girls in the region and consider strategies to address the growing crisis. They will argue that women must be at the heart of health policy debates, both in the US and abroad. It is my privilege to introduce tonight's distinguished panelists.
At the far side we have Adrienne Germain, president of the International Women's Health Coalition. Then there is Kati Marton. She is an award-winning journalist, a human rights advocate and the new board chair of the International Women's Health Coalition. Congratulations, Kati. Then we have Dr. Nirmal Bista, Director-General of Family planning Association of Nepal. And finally we have Dr. Lucille Atkin, Director of the Margaret Sanger Center International and also vice president of international programs, Planned Parenthood of New York. You have more information about the speakers in the program.
Tonight's program is part of the Asia Society's Asian Social Issues Program, known as ASIP around here. It is a public education initiative that looks at the critical social challenges and emerging strategies to address them in Asia in general. For the last four years ASIP has played an important convening role to discuss issues in human rights, including women's and children's rights, poverty, the environment, conflict, among others. We are also pleased to acknowledge the support of Bill and Melinda Gates, who through their foundation have funded a new initiative, AIDS in Asia. And tonight's event is part of this new initiative.
For those of you who may be new or who are coming here for the first time to the Asia Society, welcome. And let me take this opportunity to extend the invitation to join us through our various levels of membership and there are membership brochures outside in the lobby. Without further ado, let me turn to our panel and I would ask you to please welcome Adrienne Germain.
Adrienne Germain: Welcome to all of you and thank you for coming to discuss this terribly vital and important topic.
I visited India for the first time thirty years ago, in 1973. Indian colleagues of many backgrounds introduced me to women in isolated rural areas and in sprawling cities. Since then I have returned often to India, Pakistan and Bangladesh, usually focusing on the health opportunities and rights of girls and women. I have always ended my visits optimistic, due to the steadily growing strength of South Asian women leaders and organizations. I have always felt buoyed by increasing awareness of the central importance of improving women's lives, securing their human rights and moving toward gender equality across the subcontinent.
Last week I returned from a two-week stay in India that took me from villages in southern Rajasthan to the red light district of Calcutta and to India's Silicone Valley, Bangalore. I met with NGO leaders and staff, business men and women, government officials and donors. I talked with teenage boys and girls in Delhi's so-called resettlement areas and with young women living with HIV/AIDS. This time, for the first time in thirty years, I came home with a sense of desperation.
In the early 1980s when the first HIV/AIDS cases were identified in the US and Africa, I was living in Bangladesh. As the resident representative of the Ford Foundation, I funded the first ever research in the subcontinent on sexually transmitted diseases. I knew deeply and firsthand the circumstances that girls and women across South Asia faced, circumstances that would make them especially vulnerable to HIV. I had learned from South Asian women and girls themselves about child brides, about sexual coercion and violence, about sex discrimination and education and employment and about the failure of national programs to promote condoms or require men to respect women's rights. I knew and worked with many South Asian colleagues who wanted their countries to address these problems in their own way. I also knew that these countries needed to close the gender gaps that foster HIV/AIDS before it could gain a foothold. And I said so. But back then no one with power listened.
Twenty years later, South Asia is on the brink of an unprecedented catastrophe. Large populations and inadequate national policies and programs mean that the number of people infected and affected by HIV/AIDS in South Asia could dwarf anything we have yet seen, even in sub-Saharan Africa. India alone has an estimated 4.5 million people living with HIV/AIDS, the second largest number of such people in any one country. Some experts with whom I am inclined to agree actually estimate that the number of people living with HIV/AIDS in India is more likely to be close to 10 million and already 40% of these are female, most of them girls and young women. As elsewhere, young people in South Asia are disproportionately at risk, especially girls and young women. Well over one quarter of all the adolescents, the 10 to 19 year olds, in the entire world, live in South Asia. How they learn, what they learn and what they do about sex will substantially determine the course of their lives, their country's progress and survival and the course of the HIV/AIDS epidemic.
In India, HIV/AIDS has already spread to the general population, even to the isolated villages of Rajasthan that I visited two weeks ago. Across India and the entire subcontinent, the epidemic is driven by poverty, drought and other conditions that force men to migrate in search of work. Away from home, they have sex with women in brothels or along the truck routes or on construction sites. They return home to infect their wives and their babies. Other girls and women are at risk from sexual violence or child marriage to older men or unsafe health services and predominantly, ignorance. Most people in South Asia with HIV/AIDS do not know that they have it.
Unless we improve the status and opportunities of girls and women in South Asia and protect their human rights, there is no hope of controlling HIV/AIDS. We know what to do. Advocates, activists, practitioners for women's health and rights, inside and outside governments and across South Asia have worked for 30 years to identify effective strategies and interventions. What is needed now is massive mobilization of both government and civil society to end discrimination against girls and women and abuses of their human rights. Two of our panelists tonight will reflect on what is feasible in India and Nepal.
What about the international community, all of us here? And the global health policy makers and donors? What are we going to do and how well will we help South Asia meet these challenges. Sad to say, for me, right now the glass is half empty, not half full. Global actors are mobilizing to support interventions in South Asia like those used in Africa and the United States early in the epidemic, promoting condom use by sex workers and their clients, protecting blood supplies and working with the gay community and IV drug users. More recently, they have also begun to fund HIV counseling, testing and treatment. These are all critically important.


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Four Jolly MenRiddles are little poems or phrases that pose a question that needs answering. Riddles frequently rhyme, but this is not a requirement.
Four jolly men sat down to play,
and played all night till break of day.
They played for gold and not for fun,
with separate scores for every one.
Yet when they came to square accounts,
they all had made quite fair amounts!
Can you the paradox explain?
If no one lost, how could all gain?
HintThe answer is in `what` they were playing.
AnswerThe four men were all fiddlers in a German band and were each paid $5 at the end of the night. Most readers assume they were playing cards, but that is not stated.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
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text:
Read more: http://www.miamiherald.com/2010/03/1...#ixzz0idaAA2RN'The U' sequel on UM rebirth
Get Adobe Flash player
University of Miami coach Jimmy Johnson is carried off the field by players celebrating their national championship victory over Oklahoma, Thursday, Jan. 1, 1988 at the Orange Bowl in Miami.
University of Miami coach Jimmy Johnson is carried off the field by players celebrating their national championship victory over Oklahoma, Thursday, Jan. 1, 1988 at the Orange Bowl in Miami.
* Photo
By BARRY JACKSON
ESPN's documentary on the University of Miami football program was such a hit that the creators have begun working on a sequel.
Director Billy Corben said the new film, It's All About the U, will focus on Hurricanes football between 1992 and 2002. The first movie, called The U, primarily focused on the 1980s, through 1991.
Interviews with former Canes are being lined up for the first three weeks of April. ``Then we'll edit it the rest of the year'' while juggling nonsports projects, Corben said. He would love for the sequel to air on ESPN but hasn't discussed it with the network. Corben likely will have other options if ESPN passes.
The idea of doing a sequel ``started as a lark,'' Corben said. ``[Former UM cornerback] Mike Rumph twittered after the first movie, `What about the U-2?' A few weeks ago, we said, `Why don't we just do it?'''
Corben said the sequel ``will cover the Pell Grant scandal and the program's downfall and give Butch Davis his due for rebuilding the program. Butch did something extraordinary that deserves to be acknowledged.''
The film will spend considerable time on the 2001 team -- put together by Davis and coached by Larry Coker -- ``which is considered one of the best teams of all time,'' Corben said. ``It all comes down to what Alonzo Highsmith said at the end of the first movie about the program's success: If they had accomplished all of this at a major football university like Alabama, the school would have built monuments.
``This sequel will be the monument to the 2001 team even if the university is not as enthusiastic to memorialize their accomplishments.''
Corben also will reflect on the 2002 team that lost the Fiesta Bowl (and the national championship) to Ohio State after a highly questionable pass-interference call against UM.
``We have Larry Coker talking about that,'' Corben said. ``We didn't use any of Coker's interview in the first movie.''
Corben said UM declined to cooperate with the first film but ``I hope they will be more reasonable this time around.'' He said he wants to interview only two people currently employed by the university -- former athletic director Paul Dee (who teaches at UM) and strength and conditioning coach Andreu Swasey.
The U was ESPN's highest-rated documentary ever, with a 1.8 rating and 2.3 million viewers on its first airing. By comparison, other documentaries in ESPN's ``30 for 30'' series averaged below a 1.0 rating. ESPN said it will release a DVD of The U -- with about 30 minutes of deleted scenes -- on Amazon.com, but it isn't available yet.
ESPN's upcoming documentaries include one on Ricky Williams (April 27, 8 p.m.), Allen Iverson (April 13, 8 p.m.), Rotisserie baseball (April 20, 8 p.m.). An ABC documentary at 4 p.m. April 3 will be on Loyola Marymount under Paul Westhead.


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Scientific Name: Dermochelys coriacea
Description: Unlike other sea turtles, the bony shell of the leatherback is not visible. Instead, it is covered by a leathery layer of black or brown skin, hence their name. The shell has seven ridges running from front to back.
Size: Leatherbacks are the largest of the extant (living) turtle species. They grow to over two meters in length and can weigh up to 2000 pounds.
Diet: Jellyfish make up the biggest portion of their diet, but they also eat seaweed, fish, crustaceans, and other marine invertebrates. Leatherbacks have downward pointing spines in their throat, which allows jellyfish to be swallowed, but prevents them from coming back up.
Typical Lifespan: Leatherbacks reach maturity at approximately 13 to 14 years. Their average lifespan is unknown, but it's thought to be at least 30 years.
Habitat: Leatherbacks spend most of their lives at sea and sometimes look for prey in coastal waters. The females come on land to lay eggs.
Range: Leatherbacks are found in tropical and temperate marine waters all over the world. This means they live off of both the east and west U.S. coasts and also in Puerto Rico, the Virgin Islands, and Hawaii.
Life History and Reproduction: Adult leatherbacks have few natural predators, but their eggs and newborns are preyed upon by many animals including birds, raccoons, and crabs. Female leatherbacks return to the same nesting beach to lay their eggs. Temperature determines the gender of the offspring—if it's warm in the nest, females will be born. Likewise, if temperatures are cooler, males develop. Once the eggs hatch, they're on their own—the baby sea turtles must make it into the water and learn to fend for themselves without any care from their parents.
Fun Fact: Leatherbacks have been documented diving to over 1200 meters! By contrast, scuba divers typically descend to only about 30 meters. Additionally, the Pacific leatherback is the fastest aquatic reptile and can reach speeds of 22 miles per hour!
Conservation Status: Federally listed as endangered. Their biggest threats all stem from mankind. Clutches of eggs are often illegally poached, and the offspring that do hatch sometimes become attracted to beach resort lighting and crawl away from the sea instead of towards it. Adults are victims of poaching, entanglement in fishing gear, and they sometimes ingest plastic marine litter.
University of Michigan Animal Diversity Web
The IUCN Red List of Threatened Species
North Florida Ecological Services Office
A program that enlists the help of local volunteers is reversing the leatherback sea turtle decline in the Caribbean and serving as a model for other areas


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Posted 6 years ago
(1 item)
This is a Lord Elgin Watch, on the face it say's Lord Elgin and Quartz below it. On the back of the watch it say's Elgin LBM12ED. Wondering if anyone knows anything about the watch or maybe even possible the estimated value of it.


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Philanthropy plays an essential role in the growth and development of the Virginia-Maryland College of Veterinary Medicine. By helping us to advance our strategic priorities and fulfill our mission of training veterinarians, your gifts also benefit pet owners, industry, and society at large.
Development Goals
Our top development goals are:
Translational Medicine Building
Translational medicine involves "translating" and accelerating laboratory findings into new ways to prevent, diagnose, and treat conditions in patients. A new Translational Medicine Building will bring together interdisciplinary faculty teams from three academic colleges—Veterinary Medicine, Science, and Agriculture and Life Sciences—to turn biomedical innovations into practical, clinical applications.
The Translational Medicine Building will house an expansion of our Veterinary Teaching Hospital. This growth will accommodate more clinical trials aimed at finding better methods of disease prevention, diagnosis, and treatment. Close proximity to our Teaching Hospital will allow the use of animal models of disease and advance a comparative health sciences approach to improving human and animal health. Other areas of the building will be dedicated to laboratories and will be shared between the three academic colleges. The total project cost is estimated to be $55 million, of which $6.2 million must be privately raised by the veterinary college.
Endowed Faculty Chairs
The college is fortunate to have faculty of such renown that they are constantly being courted by other institutions. It is our goal to provide both the prestige and the additional support to ensure that our brightest and best remain here.
Equine Medical Center
The Equine Medical Center in Leesburg was founded in 1984 and is a world-class facility serving equine clients in the mid-Atlantic region. While the EMC has kept pace with the acquisition of state-of-the-art biomedical equipment, the hospital facility itself is in need of attention and has not had a major renovation since opening. In 2014, the 30th anniversary of its founding will kick off a campaign to refresh the entire facility.
DVM Student Support
The cost of higher education has gone up dramatically over the years. To ensure that our students are not handicapped with unreasonable debt, our scholarship support is crucial. Currently we award $700,000 to $1 million each year in student support. We increased our class size by 25 percent in 2012, and we need to similarly increase our ability to support our students.
Experiential Learning
Our mission is to continue to offer the best curriculum and experiences to make our students competitive upon graduation. Our Community Practice service was established in 2007 to provide more hands-on, preventive health care experience. We now have an opportunity to partner with the Humane Society of D.C. to provide even more real-life, hands-on experience for our students in a busy urban setting. Funds are being raised to help house students who opt to embrace this opportunity.


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Online social coding game that tracks skill level and performance
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Evolution Hoax
Dagbladet Information, published in Copenhagen and with a daily readership of around 110,000, carried an article on 12 February, 2009, titled "Congratulations Darwin, You Are a Liar." The report described Harun Yahya"s anti-Darwinist activities as follows:
The world is today celebrating Darwin's 200th birthday. Impressive celebrations are taking place in some countries, but this 150-YEAR-OLD THEORY IS THE SUBJECT OF MOCKERY AND TOTALLY REJECTED IN OTHERS ...
The Muslim and anti-Darwinist Adnan Oktar has now stepped up his activities. In particular, he is the individual behind the darwinism-watch.com web site that never fails to examine any of the reports concerning Darwin that have recently been appearing in the media on an intensive basis.
Today, when these 200th anniversary celebrations are taking place, the TURKISH ADNAN OKTAR HAS RECENTLY CHALLENGED THE WORLD'S SCIENTISTS TO PRODUCE EVIDENCE PROVING DARWIN'S THEORY. In a statement to The Guardian newspaper he said, "I will give 10 trillion Turkish lira if they can do this."As one of the world's best-known anti-Darwinists he has earned an enormous success with his statements and newly published books. His chez d'oeuvre is the giant 7 kg and 786 page Atlas of Creation. The book contains pictures of fossils and maintains that man never underwent any physical evolution and is the same now as he was 100 million years ago.


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The final NCAA self-study report on the University of Colorado at Boulder athletics program will be available for public review at several campus locations beginning Jan. 21.
The report is the result of a comprehensive study of CU-Boulder athletics by the campus's NCAA Certification Committee and is part of a 21-month certification process.
Public comment on the report is encouraged, said Jean Kim, vice chancellor for student affairs and head of the review process. The goal of the procedure is to ensure CU-Boulder's fundamental commitment to integrity in intercollegiate athletics.
The CU-Boulder NCAA Certification Committee consists of more than 40 students, parents, faculty, staff and administrators. Members served on several committees including four primary groups dealing with rules compliance, academic integrity, fiscal integrity and commitment to equity.
The committee's final report will be available for review at Norlin Library, the information desk of the University Memorial Center, the Office of Student Affairs in room 307 of Regent Hall and the Office of Student Services in the Dal Ward Athletic Center. Each site will receive about eight copies.
The report also will be posted on the University of Colorado at Boulder web site at http://www.colorado.edu.
Copies of the report also will be sent to the Boulder Faculty Assembly, Staff Council, University of Colorado Student Union, the Board of Regent's Athletics Committee and the offices of the chancellor and CU president for distribution as needed.
All comments on the report must be received by Feb. 28.
An outside NCAA peer review committee is scheduled to visit campus April 1 through April 4. The certification process is scheduled for completion in September.
Every college or university with an NCAA Division I athletic program must conduct a self-study at least once every five years. The NCAA certification process was piloted at CU-Boulder in 1991.
In addition to evaluating the strengths and weaknesses of the athletics program, the committee is charged with drafting plans for improving any weaknesses.
Anyone wishing to comment on the final self-study report should call Kim at (303) 492-8476 or write her at Campus Box 31, Boulder, CO 80309-0031, or contact Rich Cardillo at (303) 492-1718 or Campus Box 372.