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San Francisco, CA
Ablexis' AlivaMab™ Mouse technology, a world-class transgenic mouse platform, is being developed to provide the foundation for the efficient discovery and development of the next wave of human therapeutic antibodies to treat human diseases. Ablexis will commercialize the AlivaMab™ Mouse platform through creative partnering strategies.
Accelerator Corp
New York, NY
Accelerator New York is a leading life science investment vehicle supporting emerging biotechnology research. Accelerator will infuse strategic venture capital, entrepreneurial leadership, and critical product development capabilities into the New York City life science cluster. Accelerator NY is located at the Alexandria Center for Life Science in the heart of Manhattan's East Side Medical Corridor.
Vancouver, Canada
Aquinox is developing novel small molecule therapeutics for the treatment of cancer and inflammatory disease. Aquinox's scientific founders discovered a unique biochemical enzyme called SH2-containing inositol 5'-phosphatase (known as SHIP), which can be harnessed in the treatment of disorders such as multiple myeloma, leukemia, lymphoma, inflammation, allergy and autoimmune diseases. The lead candidate, AQX-1125, is being tested in Phase 2a studies of airway inflammation.
London, UK
Autifony is developing novel medicines to treat hearing disorders. The company was spun-out from GSK in 2011. Phase 1 studies are underway with the company's lead program, AUT00063, which is a novel pharmaceutical that targets auditory processing in the brain.
Palo Alto, CA
Aviir is developing cutting-edge, convenient molecular diagnostic tests enabling accurate diagnosis and prognosis of cardiovascular disease. The company's proprietary technology applies a deep understanding of disease marker proteins and advanced biostatistics to build prognostic profiles for atherosclerosis and is also aiming to develop a prognostic test for insulin resistance in the future.
Burlingame, CA
Biodesy is a life science instrumentation company that has developed a unique and highly sensitive means of detecting conformational change in proteins and other biological molecules. The technology can be used to measure functional activation in a protein upon binding drugs or ligands, in real time and without the need for a crystal structure.
La Jolla, CA
Celladon is focused on developing molecular therapies for cardiovascular diseases. Their first product is designed to target the key enzyme deficiency in advanced heart failure which regulates calcium cycling and contractility in heart muscle cells.
Clovis Oncology
Boulder, CO
Clovis Oncology is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents. Clovis intends to target development programs at specific subsets of cancer populations, and will simultaneously develop diagnostic tools that direct a compound in development to the population that is most likely to benefit from its use.
Boston, MA
Cydan is an orphan drug accelerator that identifies and de-risks programs with therapeutic and commercial potential. Cydan focuses on selecting promising assets with well understood biology and proof-of-concept data in animal models from academia, industry and other sources. Data generated during a rigorous de-risking process will enable formation of stand alone companies and strategic partnerships.
CytomX Therapeutics
South San Francisco, CA
CytomX Therapeutics is developing Probody™ therapeutics for the treatment of cancer. Probodies are masked antibodies that remain inert in healthy tissue but are activated specifically in the disease microenvironment. The Probody approach is designed to blunt systemic toxicities associated with antibodies and expand the therapeutic window of these drugs, unlocking new therapeutic targets. The Company is initially focused in the discovery and development of new immunotherapy and antibody drug conjugate therapies to treat major unmet medical needs in oncology.
Epic Sciences
La Jolla, CA
Epic Sciences is focused on developing novel diagnostics to improve and personalize the treatment and management of cancer. Epic was founded on a powerful platform to identify and characterize rare cells, including circulating tumor cells (CTCs).
Flexion Therapeutics
Woburn, MA
Flexion Therapeutics discovers and develops innovative therapeutics for musculo-skeletal disease. The company is currently advancing a portfolio of best-in-class candidates that have the potential to treat mild, moderate and severe forms of osteoarthritis. The independent company was founded by Mike Clayman and Neil Bodick, both deeply knowledgeable drug developers, who previously created Eli Lilly's Chorus division.
G-Con Manufacturing
Bryan, TX
G-Con designs and manufactures "PODs", portable, self-contained cGMP facility modules that offer a cost-effective and flexible alternative to large, highly capitalized pharmaceutical manufacturing facilities with fixed equipment and limited flexibility.
HD Biosciences
Shanghai, China
HD Biosciences (HDB) is a Shanghai China based clinical research organization (CRO) that provides drug discovery contract research services, with an emphasis on high value biology screening. The company has developed comprehensive technology platforms and expertise around drug discovery assays, assay development, high throughput drug screening, and hit-to-lead biology. HD Biosciences customers include Pfizer and several other large pharmaceutical companies.
Lebanon, NH
M2S is a pioneer and leader in imaging and data management technology. They were the first to develop and market 3-D imaging technology to vascular surgeons. Their Preview product is still the market leader in this field. In 2006, the company expanded into providing core lab services for clinical trials and customized data registries for physicians, hospitals, medical centers, and clinical researchers.
Utrecht, The Netherlands
Merus is building a pipeline of innovative human bispecific antibodies (Biclonics™) and single cell-derived combinations of antibodies (Oligoclonics®) for cancer therapy. Using a common antibody light chain (cLC) and CH3 dimerization technology, these full length IgG antibodies can be robustly produced at high yields from a clonal manufacturing cell line using standard approaches. Novel fully human cLC antibodies are produced following immunization in Merus' transgenic MeMo mouse.
Mersana Therapeutics
Cambridge, MA
Mersana is developing a portfolio of next-generation antibody-drug conjugates (ADCs) with superior properties not found with other ADC technologies.
MIRNA Therapeutics
Austin, TX
MIRNA is harnessing the power of tumor suppressor microRNAs to kill cancer cells by regaining control over multiple oncogenic pathways. Tumor suppressor miRNAs represent a new paradigm in cancer therapy. MIRNA's pipeline has broad utility in the treatment of solid and hematologic cancers.
MISSION Therapeutics
Cambridge, UK
MISSION is a drug discovery company focused on elucidating and targeting the ubiquitin pathway to treat cancer and other diseases. The company is developing small molecule drugs that target deubiquitinylating enzymes (DUBs) involved in the DNA damage response (DDR), which tumor cells rely upon for driving cell growth.
NeuMoDx Molecular
Ann Arbor, MI
NeuMoDx is developing a next generation testing platform for the in vitro molecular diagnostic (MDx) market. The product vision is to create a walk-away bench-top system that combines sensitivity, high speed (time to first result and throughput), low cost, and random access, in an "open" architecture that can support both IVDs and Lab Developed Tests (LDTs).
Malvern, PA
Focused on developing non-invasive therapies for psychiatric and neurological disorders using MRI-strength magnetic field pulses, Neuronetics is the first company to have a non-systemic and non-invasive depression treatment cleared by the FDA for patients who have not benefited from prior antidepressant treatment. Neuronetics is the leader in the development of NeuroStar TMS Therapy (transcranial magnetic stimulation), a non-invasive form of neuromodulation.
Gaithersburg, MD
NexImmune is developing novel immuno-therapeutics based on the proprietary Artificial IMmune (AIMTM) technology. The AIM technology has been designed to orchestrate specific immune system responses in a highly controllable and reproducible way independent of the healthiness or abundance of the patient's natural antigen presenting cells (APC). NexImmune is applying the AIM technology to the development of immuno-therapies for a variety of cancers and other diseases.
Nimbus Therapeutics
Cambridge, MA
Nimbus harnesses the power of computational chemistry to design breakthroughs for the treatment of substantial and underserved human diseases. The company's focus on metabolic diseases, cancer and immune-inflammatory disorders is driven by its selection of well validated targets that have proven intractable to the approaches taken by others in the pharmaceutical and biotechnology industry. Using its unique approach and technological capabilities, Nimbus is rapidly progressing highly selective and potent small molecules through discovery and development. The company's advanced programs include ACC, IRAK4, and Tyk2.
South San Francisco, CA
Nodality, Inc. is an emerging biotechnology company focused on patient-specific classification of disease. Nodality's technology profiles signaling networks in single cells by multiparametric phospho-flow cytometry. The technology can address many aspects of drug development with a primary focus on acute myeloblastic leukemia (AML) and chronic lymphocytic leukemia (CLL).
Haifa, Israel
Therapeutic oncology device that delivers Tumor Treating Fields (TTFields) to tumor sites through the skin. The TTfields are low intensity, alternating electric fields that cause physical disruption of dividing (cancerous) cells, but leave normal cells largely unaffected. The company's lead program in brain cancer (GBM) is has received US regulatory approval. Additional studies are also planned in other major cancer indications.
Quartet Medicine
Cambridge, MA
Quartet is an early-stage biopharmaceutical company developing drugs against a novel pain target, Tetrahydrobiopterin (BH4), an essential co-factor in the production of certain neurotransmitters.
Rhythm Pharmaceuticals
Boston, MA
Rhythm is a biopharmaceutical company developing peptide therapeutics that address unmet needs in metabolic diseases: RM-493, a small-peptide melanocortin-4 receptor (MC4R) agonist, for the treatment of obesity and diabetes; and RM-131, a small-peptide ghrelin agonist, for the treatment of diabetic gastroparesis and other gastrointestinal functional disorders.
Malvern, PA
TetraLogic is a biopharmaceutical company developing novel, targeted drugs to treat cancer. The company's Smac-mimetic candidates regulate the apoptosis (programmed cell death) pathway by unblocking the pathway to kill cancer cells.
Gaithersburg, MD
Vtesse, Inc. is a rare disease company dedicated to developing drugs for patients suffering from diseases that are underserved. The first spin-out company from Cydan Development, Inc., an orphan-drug accelerator that identifies and de-risks programs with therapeutic and commercial potential, Vtesse is working collaboratively with the NIH to advance clinical study of VTS-270 for NPC, and to conduct pre-clinical discovery and development of other novel drugs for NPC and other LSDs.
Canterbury, UK
Ziarco is a clinical stage biotechnology company developing innovative therapeutics targeting inflammatory skin diseases. The company's lead compounds are ZPL-389, an oral histamine H4 receptor antagonist entering Phase 2 studies for atopic dermatitis and ZPL-521, a cPLA-2 inhibitor being advanced for psoriasis.
Former Portfolio Companies
Aureon Laboratories Out of business
Yonkers, NY
Aureon uses systems pathology to develop predictive clinical tests for cancer care, as well as to enable bio-pharmaceutical research and development. Their technology predicts individual clinical outcomes by interrogating and analyzing tissue, to provide the first comprehensive and fully integrated view of the disease process — a systems pathology view. In 2008, Aureon successfully launched their Px+ prostate biopsy test, which has already seen very rapid uptake in the market.
Avid Radiopharmaceuticals Acquired by Eli Lilly
Philadelphia, PA
Avid Radiopharmaceuticals, Inc. is a product-focused molecular imaging company that is a pioneer in developing radiopharmaceuticals for imaging disease pathology. The company's beta-amyloid imaging agent for Alzheimer's disease is in Phase III development. The Avid team is also developing novel agents targeted to image pathology in dementia with Lewy bodies, Parkinson's disease, and has recently started a research project in diabetes mellitus.
DVS Sciences
Toronto, Canada
DVS Sciences Inc. is an analytical equipment and reagents development company that produces and markets the CyTOF® , a high throughput mass cytometer for individual cell analysis based on a novel elemental mass-spectrometry detection technology, and the MAXPAR® system of novel reagents related to massively multi-parametric assays.
Entelos Restart following bankruptcy
Foster City, CA
Entelos develops computer-based disease-simulation models, called PhysioLabs, that enable in-silico drug discovery and development. Each PhysioLab platform provides a framework for integrating data (e.g., genomic, proteomic, physiologic, environmental) in the context of a disease or therapeutic area, focusing on understanding and determining clinical responses to potential treatment. Using a PhysioLab platform, scientists create virtual patients and simulate experiments and clinical trials in silico that could take months or years to do in the laboratory or clinic.
Evolution Benefits Acquired by Genstar Capital
Avon, CT
Evolution Benefits (EB) offers innovative, integrated products for the employee benefits market. Their Benny™ prepaid benefits card acts as a comprehensive tool for managing the front and back-end functions involved in executing employee benefit programs, including flexible spending accounts, health reimbursement accounts, health savings accounts, and qualified transportation accounts. EB's products make benefits programs easier for consumers to use, while at the same time reduce administrative burden to benefit managers. Note: Acquired by Genstar Capital
Genomic Health
Redwood City, CA
Genomic Health is focused on the development and commercialization of genomic-based clinical diagnostic tests for cancer that allow physicians and patients to make individualized treatment decisions. In early 2004, they launched their first test under the brand name Oncotype DX® for early stage breast cancer patients. Note: IPO in 2005
HandyLab Acquired by Becton Dickinson
Ann Arbor, MI
HandyLab develops and manufactures small, low-cost nucleic acid and protein-based analysis systems based on its patented and proprietary microfluidic, miniaturized real time PCR, and nucleic acid extraction technologies. The company's lead product, Jaguar, combines rapid nucleic acid sample preparation with microfluidic PCR for nucleic acid detection. Note: Acquired by Becton Dickinson
NeuroTherapeutics Pharma Out of business
Chicago, IL
NeuroTherapeutics Pharma, Inc. (NTP) is a biopharmaceutical company focused on developing therapies for diseases associated with central nervous system hyper-excitability. The company is working with novel mechanisms that will generate first-in-class therapeutics, thereby changing the standard of care for patients suffering from epilepsy, neuropathic and acute pain, and other disorders of the nervous system.
superDimension Acquired by Covidien
Minneapolis, MN
superDimension has developed the inReachT system in answer to one of the most critical needs in the field of pulmonology: minimally invasive access to peripheral lung locations. The inReachT system enables accurate and minimally invasive navigation anywhere in the lungs in real time and on a 3D CT roadmap, increasing both the success rate and applicability of diagnostic bronchoscopy.
Supplyscape Merged with Tracelink
Woburn, MA
Provider of pharmaceutical supply chain security solutions to pharmaceutical companies and their trading partners seeking to enhance product integrity and supply chain efficiency. The company has developed technology to track and store the movement of drugs throughout the pharmaceutical supply chain using radio frequency identification to protect the drug supply from counterfeiters. Note: Company acquired


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The English Department has two functions. First, it serves the general-education curriculum of the college by providing instruction in reading, writing, research, analysis, and argumentation in its composition courses and by shaping students' informed thought through the study of literature. Second, in its major and minor programs, the Department continues to stress skills in reading, writing, and thinking while expanding the study of literature to provide students a thorough historical and cultural context that deepens their knowledge of the literary canon.
The English Department strives to:
- provide students a foundation in literature and writing as components of the liberal arts;
- assist students with thinking analytically, communicating effectively, and discriminating among ethical, moral, and spiritual values;
- foster the discovery, development, and critical appraisal of knowledge;
- provide programs based upon research and scholarship which will equip motivated students with knowledge, skills, experiences, and competencies needed to do advanced academic work in English and related fields, or to serve as a basis for professional schools and related vocations;
- encourage a community of personal, caring, and mutually respectful relationships between faculty and students, recognizing the dignity and worth of each individual;
- foster integrity, tolerance, understanding, and appreciation of conflicting points of view;
- enable students and faculty to broaden their awareness of cultural diversity both in this nation and among the nations of this world;
- enhance the social and intellectual development of students through Department-sponsored extra-curricular activities and organizations.

subset: commoncrawl


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MIAMI -- After the four-day All-Star break, manager Bruce Bochy had plenty of updates during his pre-game media session. They weren't positive.
Matt Cain was wearing a sleeve on his right arm and Bochy said the right-hander's "elbow has been cranky at times going back to spring training." Cain was the No. 2 starter in the first half, but will take the ball fifth in the second half. Bochy said Cain threw Thursday and felt fine.
"Right now, he's scheduled to go (Tuesday in Philadelphia)," Bochy said. "He should be good to go."
Cain has had a sore arm before and has bone chips in the elbow that Bochy said can sometimes move around a bit. Cain was also wearing the thin sleeve last Sunday, the day Bochy revealed his revamped rotation. Asked Friday if anything was bothering him, Cain said he was fine.
"I'm feeling like I'm feeling," he said.
There are concerns with the lineup, too. Marco Scutaro was out of the starting lineup because of a stiff neck. The injury is new and not related to Scutaro's bad back. Scutaro has been in the lineup just once in four games since being activated last Friday, but Bochy expected to have him available as a pinch-hitter for the series opener with the Miami Marlins.
The Giants don't expect to have Angel Pagan back for a while. Pagan still is not swinging a bat, Bochy said, and is only running and doing other conditioning work at the team's facility in Scottsdale. Pagan is still recovering from an epidural in his lower back and is unlikely to play anytime this month.
There was one bit of good news Friday: Pitching coach Dave Righetti was released from the hospital after an overnight stay in Las Vegas. The team flight to Miami had to be diverted Thursday morning because Righetti was feeling vertigo-like symptoms. The Giants stopped in Las Vegas for 45 minutes and Righetti was taken for tests. Because he is unable to fly, Righetti will miss the entire road trip.


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Psychologist Jerome Bruner said it best: "No educational reform can get off the ground without an adult actively and honestly participating—a teacher willing and prepared to give and share aid, to comfort and to scaffold...You can't teacher-proof a curriculum any more than you can parent-proof a family."
In other words, when the bell rings and the classroom door closes, it's all about the teacher. Unless she's motivated and supported, even the best reform ideas are going to flop.
Read SFPS teacher Eric LeMasters' recent column in the Santa Fe New Mexican to see how motivated and supported he's feeling these days. He's in no space to embrace new ideas from the incoming superintendent, and if you talk to other teachers, you'll find he's not alone.
Which means the best way—the only way—to change Santa Fe's schools is to change the way we treat our teachers.
Don't look to our leaders on this one. Obama's $1 billion dollar "incentivizing" program and Gov. Susana Martinez' proposed teacher evaluation system—protested by hundreds last week—are just the latest in the trend of carrot-and-stick policies that dole out rewards or punishments based on teacher "performance."
They're models from the corporate world, designed to train hedge fund managers and other money-makers, whose performances are easily assessed in dollars. But how does one evaluate the "performance" of a teacher sharing Shakespeare, or photosynthesis, with 14-year-olds? Does she lose points for the kid who falls in love with literature but freezes on the unit-end test? The kid who's struggling to decode words? The kid who needs a bad grade to piss off his parents?
By contrast, look at the way teachers are treated in Finland, education's hottest success story. Since the 1980s, Finnish teachers have been given proper training, good salaries, real autonomy in the classroom and support from social service and health workers for their students. Treating teachers well, Finland has grown a corps of collaborative, focused professionals who use the best techniques to help their students grow—even when measured on standardized tests.
Santa Fe could follow suit. We'd start by establishing a minimum salary of $50,000 for every teacher in the city. If the Legislature can't do it, then the city, or a motivated group of citizens, could. (By my rough estimates, it would cost us about $100 a year per person.)
But pay is not enough. We need to chip in to fund more support services for children and families, and more professional development like the Academy for the Love of Learning's Teacher Renewal Program. (Full disclosure: I'm on contract with the Academy.) Run in partnership with the district, the program brings teachers together to explore their craft, share experiences and remember why they went into teaching. To date, it's given more than 250 Santa Fe teachers a refuge against high-stakes testing and humiliating school "report cards," and a way to stay passionate and focused on learning.
2. Start a Slow School Movement.
The Slow Food movement is thousands of people strong in some 150 countries, raising awareness about how we treat our planet and bodies. Santa Fe is the perfect place to launch its education counterpart. Modern brain research, and the failure of No Child Left Behind, have proven that you can't pressure children into learning more, faster. A Slow School movement would celebrate and encourage teachers, parents and schools who give children the space, guidance and time to learn in reflective, open-ended and engaging ways.
3. Imagine the Possibilities.
Over the last year, I've visited successful schools that have no bells or classes; schools where kids spend half their week off-campus; schools with no set curriculum. Fifteen years ago, I would have dismissed them as outliers with little to offer mainstream public schools. But that was before 9-11 and the recession, before the consequences of global warming seemed so imminent. Major changes are coming, and if we're going to negotiate them with grace, we must open our minds and begin reimagining what—and how—we want our children to learn.
Seth Biderman is under contract with the Academy for the Love of Learning to research different learning models and further public conversation about what "school" could someday be in Santa Fe. Biderman is a graduate of SFPS and a former Santa Fe teacher and administrator.


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Check Emergency Supply Kits, Smoke Alarms This Weekend
Oct. 27, 2009
News Highlights
More Information
This Sunday, Nov. 1, marks the end of daylight saving time, when clocks will be set back one hour beginning at 2 a.m.
Public education by fire and rescue officials encourages residents to change smoke alarm batteries every six months. A good way to remember is to change the batteries when clocks are changed at the beginning and end of daylight saving time.
The Fairfax County Office of Emergency Management reminds residents to also use the end of daylight saving time to check and restock emergency supply kits in their home, office and cars.
"While residents are changing batteries in the smoke alarms in their home this weekend, we want them to remember to check their emergency supply kit to ensure that it is fully stocked and they are prepared for emergencies," says Dave McKernan, Fairfax County's emergency management coordinator. "Daylight saving time is a great time to think emergency preparedness."
For more information about emergency supply kits or the types of items that should be included, contact the Fairfax County Office of Emergency Management at 571-350-1000, TTY 711, or online, or visit www.makeaplan.org and www.ready.gov/america.
Contact: Merni Fitzgerald, Director, Office of Public Affairs
703-324-3189, TTY 711, Media Pager: 703-324-NEWS (6397)
To request this information in an alternate format, call 703-324-3187, TTY 711


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Photo Gallery - Listing ID A4122384
- Listing Price$5,999,000
- StatusActive
- Address415 L AMBIANCE DRIVE PH-C
- LONGBOAT KEY, Florida 34228-3908
- Bedrooms3
- Full Baths4
- Total Baths5
- Partial Baths1
- Square Feet4,711
Julie loves the Sarasota's Suncoast area and gets a lot of joy out of matching up home buyers with home sellers and creating a win-win situation for all involved.
ThinkSuncoast.com is your one-stop real estate resource for Sarasota and the surrounding areas. ThinkSuncoast.com Wants to Know What YOU Think! Leave your questions and/or comments below.
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Our objective, whether your surgery is cosmetic or reconstructive , is the customize the procedure to fit your needs. Our highly trained staff is dedicated to providing the latest in medical and surgical care with the primary goal: to make you feel better about yourself.
Wednesday 10:00 a.m. - 5:45 p.m. Friday 10:00 a.m. - 3:45 p.m.
Cosmetic Surgery all aspects, Breast Surgery, reconstructive surgery
Consultations are complimentary. Patients are usually evaluated on Wednesdays and Fridays.
Our Office surgical facility is certified by the AAAASF. Most of the common cosmetic procedures are performed in our certified facility. Our highly trained staff provides a conforting recovery with personal care.
- University of Michigan, B.S.
- Wayne State University, M.D.
- Mount Carmel Mercy Hospital-Internship, General Surgery
- Northshore University Hospital-Residency-General Surgery
- Nassau County Medical Center-Plastic Surgery Residency
- Detroit Receiving Hospital-Burn Fellowship (Wayne State Univ.)
- American Board of Plastic Surgery 1994
- American Board of General Surgery 1989
- American Society of Plastic Surgeons
- American Society of Plastic Surgery
- American Society of Aesthetic Plastic Surgery
- American College of Surgeons
- American Burn Association
- American Medical Association
- Oakland County Medical Society
- Naitonal Medical Association
- Beaumont Hospital, Royal Oak, MI
- Providence Hospital, Southfield, MI
- Detroit Medical Center Hospitals, Detroit, MI
- St. John Hospital, Detroit, MI


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Three Top Honors for County Web Site
Oct. 30, 2009
News Highlights
More Information
Fairfax County's public Web site, fairfaxcounty.gov, has been honored as one of the top county government sites in the nation. It was recognized by the Virginia Coalition for Open Government, the Center for Digital Government, and the Digital Counties Survey.
Freedom of Information Award
Fairfax County and the city of Alexandria share the Virginia Coalition for Open Government's Freedom of Information Award in the government category. Fairfax County was recognized for its efforts to engage the public in addressing the $650 million revenue shortfall for FY 2010. The county solicited public input online, by telephone and at community dialogue sessions to help identify solutions for closing the budget gap. There also was an extensive media campaign and outreach through social media platforms such as Facebook, Twitter and YouTube.
"This is exactly what we were striving for when we started our e-government program more than a decade ago," notes Deputy County Executive David J. Molchany. "We wanted to create a government without walls, doors or clocks and provide a way for residents and businesses to access our information and services 24 hours a day."
Best of the Web Award
The county earned top honors in the Center for Digital Government's 2009 Best of the Web awards. Fairfax County's site took first place in the county Web portal category. Best of the Web ranks the top U.S. state and local Web portals, recognizing advances in digital solutions and communication with the public, government communities and business. Fairfax County's Web site has now earned a Best of the Web award four times since 2003.
Digital Counties Survey
Recognizing best practices and counties with exemplary digital service to residents, the 2009 Digital Counties Survey selected Fairfax County as the fourth place winner in the 500,000 or more population category. This marks the fifth consecutive year the county has ranked in the survey's top five.
Contact: Merni Fitzgerald, Director, Office of Public Affairs
703-324-3189, TTY 711, Media Pager: 703-324-NEWS (6397)
To request this information in an alternate format, call 703-324-3187, TTY 711


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Marlborough residents looking to make new friends while enjoying a home cooked lunch can take advantage of a new drop-in scheme at Coombe End Court.
From 11am to 2pm on Mondays and Wednesdays, people can visit the care home and,for £5, have a two-course lunch served at 12.30pm.
Day centre co-ordinator Di Palmer said: "I think people get a bit lonely at home by themselves so they can come here and have a nice chat with people who use the day centre and others who have just come for lunch.
"They have a choice of two mains and two puddings and all they have to do is turn up at 11am and let us know they want lunch."
The drop-in days aim to show people the benefits of day centres and were officially launched by Claire Perry.


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Green brightens his future with solid spring
PHOENIX -- Grant Green is a Minor Leaguer who garners attention from fans as though he were a Major Leaguer.
That's because once upon a time, Green was considered to be the A's shortstop of the future. But four years have passed since he was taken in the first round out of the University of Southern California, and fans have been forced to temper any excitement surrounding his potential with patience.
The 25-year-old entered spring swimming in a deep, crowded infield pool, his chances of breaking camp with the team very slim. So despite the fact that he hit .409, with a good showing at his new home at second base, the decision to option him to Triple-A on Sunday wasn't much of a surprise.
Still, his performance was enough to convince a few in the front office that the talent is still there and that he very well may still have a future in Oakland once the crowded infield disperses.
"I think he's made terrific progress from what we saw last year, especially for a guy that's had to play multiple positions and get moved around," manager Bob Melvin said. "He didn't allow it to affect his at-bats. It was a really good showing for him this spring, and I think he's got the chance to get comfortable and be a real good second baseman."
Of Green's nine hits in camp, five went for extra bases. But hitting has never been the problem, as his .302 Minor League average would suggest. Defense has been the bigger question, and the A's have tried him at multiple positions in an effort to determine where he's best suited, including the outfield and third base.
They seem to have found the answer at second base. Of course, that's where the competition is fiercest these days. But even though he remains blocked, Green is staying put, it seems.
"He's a good enough athlete to probably play anywhere, and that probably works against him," Melvin said. "He's played in the outfield, was a shortstop coming out of school, now he's at second base. I'm sure he can play first. There's a lot of things he can do, but we feel he's going to be able to handle second base nicely."
Jane Lee is a reporter for MLB.com. Read her blog, Major Lee-ague, and follow her on Twitter @JaneMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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(If anyone is interested, you can see my whole set of House Renovations Photos on Flickr.)
Friday Night Photos: House Renovations v. 2.0
(If anyone is interested, you can see my whole set of House Renovations Photos on Flickr.)
Friday, November 14, 2008
oh, house renovations are so exciting! Thank goodness the inside is done already; you can hide inside and pretend the other work is finished! :DReplyDelete
You have quite a lot of work ahead, but it's going to look fantastic when it's all done. And you'll have your party porch back. :-)ReplyDelete
Thanks for photographing -- it's going to be such fun to watch the progress of this project, and to celebrate with you at its completion!ReplyDelete
you have such a sweet looking house. congratulations on going for some more updates! porch parties will be worth the noise you are enduring. how exciting!ReplyDelete
Fabulous to let us follow along on this! I really enjoy re-doing - appreciate the headaches during but the rewards are thrilling. Love the party porch!!ReplyDelete
Good lord, you have been busy. A wonder you can blog at all! i feel ya on the sickness -- i've been sick forever ... can't seem to get over it. But yes, the blog is alive :)ReplyDelete
Anita, it is fun isn't it? Not doing the kitchen though; I'm sure you remember it well.
Andrea, thanks. Cannot wait for the new porch, plus the back decks will be good for photos!
Lydia, that will definitely be a huge celebration!
Renee, thanks. It's a tiny house, but I do love it.
Tanna, I hope it doesn't get too boring, because I'm guessing this project will last a long time. Maybe I can sneak in a few photos of the inside of the house!
Vanessa, so happy to see your blog pop up in the feed reader! It's the Utah winter sickness I guess. I'm so tired of it, two weeks+ for me now. But I'm finally getting a little better.
Someday when I grow up, I want a house like yours. Lots of charm, not too big and renovated the way I want. I will bet it is loads of fun to plan out the colors and stuff. Jealous jealous me...ReplyDelete
Rookie Cookie, don't forget I've been teaching school for a looooooong time to get a house this good (and money for renovations.) And it's a tiny little house too.
It is definitely fun though. I love being able to make it just the way I want it!
Ohhh, that will be just beautiful. Not that it's not already. I love old houses. I'm just getting a new kitchen floor and I'm excited.........lol
I do miss having a porch though.
Wow, I love your house! It is so pretty! I love that style. I can't wait to see the renovation as it takes place. Looking forward to it.ReplyDelete
How fun (for us to see)! Can't wait to see the final "product". Love SLC!ReplyDelete
Wow you are so brave to start this big project just before the holidays and at the beginning of winter. Here's hoping they are all gone when you start to plant your gardens in the spring. Good luck. House is adorable and will be even better after all the work you are planning. Keep posting the photos. And I agree with a previous poster, where do you get all the time to do everything you do? Feel better.ReplyDelete
What an adorable house! Good luck with all of your renovations. I know what a pain it can be. I'm sure it will be so worth it! Can't wait to see the end result!ReplyDelete
LOOK FORWARD TO SEEING ALL THE RENOVATIONS. BY THE WAY I LOVE YOU BLOG I STARTED THE SOUTHBEACH DIET 3 MONTHS AGO AND YOU BLOG HAS HELPED ME ALOT. THANKS, TINA-ALABAMAReplyDelete
Such a cute house - its going to look fantastic once you finish the work outside!ReplyDelete
Wow! That's some serious work there, but so worth it. There's nothing like a welcoming porch!ReplyDelete
Thanks everyone. Believe me, I would have loved to get this started sooner, but you have to do it when the contractor can come! Hopefully it will be done without too many breaks for snow days.ReplyDelete
Your house looks just like I thought it would, or at least the renovations will make it look like I thought. Love the mountain sage and white -- yes, I did go look the color up! LOLReplyDelete
Kalyn, I love your house. Those Bungalows are my favorite style--so cool! Congrats on the new porch and siding. You'll feel like you have a new house.ReplyDelete
How do you find the time??? Teaching, blogging and a remodel too! I'm impressed...ReplyDelete
Kalyn, I love your house! Please show some pictures of the inside!ReplyDelete
Oh yes, I'll definitely show some photos of the inside at some point in this process. And for those who are wondering how I can do everything, it's actually kind of sad but I never have time to watch TV, read a book, or even go to the movies. This is why I MUST retire, so I have time to have some fun again.ReplyDelete
I love bungalow houses! It's the one thing I miss from the Midwest. We went to St. Petersburg last year and were so excited to see bungalows that DH and I just drove around looking at all the different houses! I can't wait to see the final result (and I enjoy watching the work in progress too).ReplyDelete
What fun, Kalyn! I can't wait to learn more.ReplyDelete
How exciting...really cute house.
will be about perfect when your done.
Thanks for the pictures.
Your house is so cute! I love that style of house. There's something very charming and cozy about it.ReplyDelete
Ooh! I can't wait to see it when it's all done. I bet it's going to look gorgeous!
I love remodeling...I'm a sucker for HGTV.
You live in a place called Sugarhouse? How *sweet* is that? I can't wait to see the improvements. How exciting!ReplyDelete
For anyone who's wondering, this part of town is called Sugarhouse because back in the late 1800's there was a sugar factory here. So it really is sweet! (BTW, the entire porch is now gone.)ReplyDelete
House renovations.... Yep, I can relate... As I sit here in an empty room while mon mari stains ceiling boards....
I love your house, now I want to see the inside.
Sorry I missed the big 3 celebration but without only internet cafes for 2 months it's been a challnge. I'm slowly dipping my toes back into the online world....
Oh Katie, no worries. I absolutely knew why you didn't participate. Nice to see you back!ReplyDelete
I'm so happy you're taking the time to comment on Kalyn's Kitchen! I love hearing from people who stop by, especially if you're sharing feedback or asking questions about a recipe I've posted here.
I've recently changed my comment settings so people can comment without signing in, but you will need to check the box to show you're a live person, and comments on older posts won't show up until I publish them. Thanks for understanding!
And if you really like the recipe, Pins, Shares, Tweets, and Yums are always appreciated!


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TUCSALOOSA _ Usually when the University of Alabama plays Arkansas in an early-season benchmark game of the Southeastern Conference's Western Division, most fans conjure up images of big linemen, hard hits and a day worthy of the words "pig suey."
That's usually. Saturday wasn't quite like that at Bryant-Denny Stadium, where the No. 3 Crimson Tide was clearly thinking showdown and able to back it.
While Arkansas had a Mallett named Ryan, Alabama essentially brought a sledgehammer to pound out a 35-7 victory.
"That was a good football team we played out there today, very good offensive team," Coach Nick Saban said. "I was really pleased with the defensive effort out there today. To hold those guys to seven points is really good and it was a team effort."
Although much was made of the 6-foot-7 sophomore quarterback and his cannon arm, which was thought to be the only way Arkansas could pull off the upset, the Crimson Tide (4-0 overall, 1-0 SEC) played as if it had been personally insulted.
Actually, in a way it had.
"We have a group of wide receivers and running backs who are as explosive as any group in the country, and we feel very strongly about that and their ability to make plays," said junior quarterback Greg McElroy, who completed 17 of 24 passes for 291 yards and three touchdowns without any interceptions. "I stood up at the end of our meeting last night after watching film and said, 'You know what, I'm sick and tired of hearing about how Arkansas has such an explosive offense. We can be those guys too.'
"It's one of those things, we went into the game with a chip on our shoulder and guys made plays."
So did the defense, which treated Mallett, a transfer from Michigan who was making his first SEC road start, as if he had a lot of nerve even showing up. From the first series, when sophomore end Marcell Dareus almost probably made his eyes bug out, the quarterback was on the move as the Razorbacks converted only two of 14 third-down opportunities. The final tally was three sacks, eight tackles for a loss and eight pressures, while he was 12-for-35 with one touchdown and an interception.
Overall, the Razorbacks averaged just 3.8 yards per play, while Alabama was more aggressive and explosive on both sides of the ball.
"That's what we're trying to make our identity, especially on defense, especially up front, to always be the more physical team, to out-physical whomever we play, so they don't ever want to come back and play us," said senior defensive end Lorenzo Washington, who blocked a punt. "Every day in practice, Tuesday, Wednesday, we put great emphasis on being physical in practice. Practice translates to games."
After a lackluster scoreless first quarter in which the Tide had three dropped passes, the offense finally started clicking in the second quarter when true freshman running back Trent Richardson turned what should have been a short loss into six points.
On second-and-5 at the Tide 48, Arkansas called a run-blitz which Richardson ran right into on the right side, but the true freshman broke tackles from linebacker Wendel Davis, safety Tramain Thomas, defensive end Adrian Davis and linebacker Jerry Franklin, found the sideline and just kept on going.
"That kicked things off for us," sophomore running back Mark Ingram said.
If that wasn't disheartening enough for the Razorbacks (1-2, 0-2), the Tide's next offensive play was the equivalent to dropping an emotional anvil. Alabama lined up, shifted to the wildcat formation, with McElroy wide alongside sophomore Julio Jones and then pulled back as of to avoid the play coming toward him.
However, it wasn't an end-around carry to junior Terry Grant as Arkansas believed, and instead of turning up field the receiver pitched the ball back to McElroy, who had Jones wide open downfield. Not only was the 50-yard score the sophomore's first reception since being sidelined by a bruised knee in the first half against Florida International, but snapped his 11-game touchdown drought.
"He was so wide open I was scared to death I was going to miss him," McElroy said.
Meanwhile, the Tide's defense remained unrelenting and unyielding, giving up 27 rushing yards and 101 passing in the first half. Although the Razorbacks had a small advantage in time of possession, their longest drive of 50 yards was aided by a fake punt and pass-interference penalty.
The Hogs' best offensive showing of the day came on their initial possession of the season half, when senior cornerback Javier Arenas, who had two sacks earlier, was picked up on a blitz which combined with blown coverage resulted in 25-yard gain to set up Greg Childs' 18-yard touchdown.
Only Alabama answered in a big way. On first-and-10 from the Alabama 20, sophomore Marquis Maze faked a cut-off route and when junior cornerback Rudell Crim bit the sophomore streaked down the sideline for an 80-yard score.
"I was just happy I made it, and it came at the right time," Maze said. "It blew the game open."
That was followed by Washington's punt block to set up a 14-yard touchdown reception by Ingram, and a 99-yard touchdown drive that made most of the fourth quarter irrelevant.
The only setbacks along the way were sophomore linebacker Dont'a Hightower likely being out for the season with a knee injury, and Arkansas' run-focused defense limiting the Tide to 134 yards on 41 carries.
"My message to the team was, 'If you haven't sold out to the team yet, what are you waiting for?' Saban said, later adding, "It was a great team win."


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Marlins announce early-season Saturday concerts
JUPITER, Fla. -- Willy Chirino, Fatman Scoop and Coolio featuring Biz Markie will perform at Marlins Park in the first three Saturday Spectacular postgame events in Miami.
After the respective games, fans can go to the West Plaza for the concerts, beginning with the Grammy Award winner Chirino on April 13 after the Marlins' contest against the Phillies.
Coolio and Biz Markie will perform April 27, and Fat Man Scoop will perform May 18.
All 13 Saturday home games this season will feature a pregame party on the West Plaza, with live music on the main stage, appearances from the Marlins and Office Depot Sea Creatures, interactive displays and other entertainment. Postgame events are included with the price of admission to the game on those days.
Joey Nowak is a reporter for MLB.com. Follow him on Twitter at @joeynowak.& This story was not subject to the approval of Major League Baseball or its clubs.


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'I don't pretend to understand all the ins and outs of the NHL collective bargaining agreement and the mechanics of a lockout. This time, if not the last, I tend to come down more on the side of the players than the owners … but then I've always tended more toward the rank-and-file than the people-sitting-in-the-big-office sorts. But at the same time, neither can I truly relate with people who are ultimately getting paid more money than I'll ever see … to play a game.'
You are here: Home / SabresBeat / Opportunities lost in NHL lockout


text: Oregon Wave Energy Trust http://hdl.handle.net/1957/15497 2017-09-09T15:00:38Z Market Analysis Report for the Pacific Marine Energy Center South Energy Test Site http://hdl.handle.net/1957/50926 Market Analysis Report for the Pacific Marine Energy Center South Energy Test Site Hassan, G.L. Garrad The objective of this study is to identify potential end-users of the test center and their needs. The findings will inform the infrastructure design and the services offered for the PMEC South Energy Test Site. 2013-12-09T00:00:00Z Incentivizing Ocean Energy: Renewable Energy Credit Certification Process http://hdl.handle.net/1957/50925 Incentivizing Ocean Energy: Renewable Energy Credit Certification Process Schay, Alex; Carbon Solutions Northwest, LLC The Incentivizing Ocean Energy project, completed July 2011 by Robert K. Harmon, studies methods of bridging the gap between the cost of ocean energy and the price it can command in the marketplace, especially for early-stage technologies. Robert K. Harmon details strategies to reduce the cost of ocean energy, gain political support, advocate for favorable treatment in regulatory markets and make the best use of voluntary markets. Methods include building alliances, focusing on grants, benefiting from tax incentives, preferential siting, working collaboratively with other sectors and more. This report is a go-to guide on how early-to-mid stage businesses will best profit from ocean energy devices in both the short and long term. Incentivizing Ocean Energy: Renewable Energy Credit Certification Process supplements the initial report with more current information and serves as a guide for businesses on how to attain ocean energy certification. 2012-11-01T00:00:00Z Winter Marine Bird Surveys February 16 - March 6 2012 http://hdl.handle.net/1957/50923 Winter Marine Bird Surveys February 16 - March 6 2012 Mills, Gregory Information on winter marine bird and mammal distributions in Oregon coastal waters has been identified as a data need for marine spatial planning of ocean energy development. As part of the annual marine mammal surveys of the critical habitat for Endangered Species Act (ESA)-listed Southern Resident Killer Whales (Orcinus orca), National Oceanic and Atmospheric Administration (NOAA) Fisheries mobilized a winter research survey during 16 February to 06 March 2012. To study marine birds. Partnership between NOAA Fisheries Northwest Fisheries Science Center (Conservation Biology and Fish Ecology divisions) and the Oregon Wave Energy Trust (OWET) allowed the principal investigator to place two contract seabird observers on board the Shimada for the entire survey. Deployment of seabird observers during this winter survey allowed quantitative information of marine bird species, abundance and behavior to be collected during all daylight hours when the ship was under way and weather conditions permitted. This report is meant to provide a concise data summary of methods, survey dates and locations, and basic information about bird species seen during the surveys. It is not a final analysis, nor have data been fully processed to provide absolute at-sea density estimates. Marine mammal observations and other ecosystem data collection were funded entirely by NOAA Fisheries; these data are in the custody of M. Bradley Hanson and Dawn Noren, who served as Chief Scientists for the 2012 research survey. 2012-03-01T00:00:00Z 2011-2013 Biennial Report http://hdl.handle.net/1957/50918 2011-2013 Biennial Report Oregon Wave Energy Trust Oregon Wave Energy Trust (OWET) is a nonprofit public-private partnership funded by the Oregon Innovation Council. Its mission is to support the responsible development of wave energy in Oregon. OWET emphasizes an inclusive, collaborative model to ensure that Oregon maintains its competitive advantage and maximizes the economic development potential of this emerging industry. Our work includes stakeholder outreach and education, policy development, environmental assessment, applied research and market development. 2013-01-01T00:00:00Z


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If the contract was "reasonable" by NBA standards, I might agree to extend Roy NOW. Big men of his calibur are so rare and he has improved every year. My fear is the market will dictate we "over pay" him
Plus some teams will throw a above average offer on the table just to make us pay more
Hill on the other hand, I agree with waiting, although I think we under esamate him here a little. Guy has a wining pedigree, playing under arguably the best coach in the game (Pop) is only 25 or something.
I could see him geting 4 years for 28M or so


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SJ Entrepreneur Challenge Round 2
SJ Angels
Wednesday, March 26, 2014 from 5:00 PM to 8:30 PM (PDT)
Event Details
Will we see the next Duraflame log or California Cooler tonight? Who will win cash and other prizes? Audience members will help the judges name the first and second place winners of the inaugral S.J. Challenge. Prizes totaling $10,000 in cash and $14,000 in professional services will be awarded to the best business ideas or inventions. Complimentary light appetizers will be served and a no-host bar will be available.
Please note, jeans are not permitted in the Stockton Golf and Country Club (location of event). We appreciate your willingness to comply with the Club's dress code.
You do not need a ticket for this event. Your reservation will be held in your name at the registration desk. Therefore, each reservation needs her/his own name!
When & Where
Stockton Golf & Country Club
3800 Country Club Boulevard
Wednesday, March 26, 2014 from 5:00 PM to 8:30 PM (PDT)
Add to my calendar


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Why is Santa a bit peeved in Jalmari Helander's "Rare Exports"? Um, hanging him from the ceiling will just about tick anyone off, apparently. Check out a clip from the imported horror flick "Rare Exports". You can read our review of the movie here.
On the eve of Christmas in northern Finland, an archeological dig unearths Santa Claus. This particular Santa, however, isn't the one you want coming to town. When most of the town's children go missing, Pietari and his father, a local hunter named Rauno, come into possession of the mythological being. Rauno's clan of hunters attempt to cash in on the opportunity by selling Santa back to the misguided leader of the multinational corporation sponsoring the dig. What ensues is nothing short of a wildly humorous nightmare — a fantastically bizzare polemic on modern day morality.
Starring Per Christian Ellefsen, Peeter Jakobi, Tommi Korpela, Jorma Tommila, Onni Tommila, Jonathan Hutchings and directed by Jalmari Helander.
The film is due out in limited release Stateside December 3, 2010.


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Victoria tourism in 2009 not surprisingly suffered from the recession, new USA passport requirements and the dollar exchange rate. Our spring was good but then July and August were significantly down.
Since this theoretically afforded us some spare time I took four partial days off to enjoy some aspects of tourism in Victoria. The highlight was three hours sailing in Victoria with two family members – do read about it. Here you see us on the bowsprit of the tall ship Thane. It was wonderful and something to do again next year.
The other days deserve a post apiece but should be mentioned briefly as further recommendations for your planning of a visit here.
A) Flying through the upper canopy of a forest may not appeal to everyone but ziplining is fabulous. Ten of us from Victoria hotels and bed and breakfasts went west towards Sooke for an exhilarating afternoon.
B) Down to earth, the other two trips were to local regional parks to enjoy superb hiking. Gowlland Tod and East Sooke parks both offer a variety of terrain with paths for a casual stroll through to a stiff climb. The hiking part of our website has to be developed so more will follow in the future. When here do ask for recommendations and we will suggest routes meeting your requirements.
Clearly we hope that Victoria tourism will bounce back in 2010. We will take a break for some of the winter and re-open before the Winter Olympics. We hope to see you next year!
Martin and Linda.


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Instrumental miking such as saxophone Miking of drums (toms, hi-hat) MS-stereophony with M 130 beyerdynamic is one of few microphone manufacturers world-wide that still produce ribbon microphones. A classic one is the M 160, a dynamic double ribbon microphone. Featuring a hypercardioid polar pattern with a noise attenuation of 25 dB at 110°, the M 160 is an outstanding microphone which is very effective for all types of remote and in-studio voice reproduction. In the recording studio, the M 160 is recommended for miking string instruments such as violins, violas, cellos and for pianos, saxophones as well as for hi-hat and toms. The non-glare black surface of the M 160 and its small dimensions allow the unobtrusive use in TV or film studios. In conjunction with the M 130 dynamic double ribbon microphone the M 160 is ideal for stereo recordings in MS technique. Features
beyerdynamic GmbH & Co. KGTheresienstr. 874072 Heilbronn - GermanyQuestions regarding Orders, Payment & DeliveryPhone: +49 7131 617-444Product AdvicePhone: +49 7131 617-440Contact us per e-mail:proaudio @beyerdynamic .com
www.bonedo.de 05/2016Title: Beyerdynamic M 160 ReviewAuthor: Nick Mavridis
Translated from the original German article
Considering (...) that this classic is the product of a world-renowned traditional company, makes a statement to the microphone particularly interesting: With a price of 500 Euro the transducer can be described as very reasonable, because for that amount you usually get only ribbon microphones from Far East or Russian production - English or American Ribbons with such quality characteristics are more expensive.
First of all, alternatives to the Beyerdynamic M 160 are rare or practically not existing. Only very few ribbon microphones supply another polar pattern than eight, in combination with a very small size and a good price there are simply none. And these are the advantages: You cannot or want always use a huge microphone. The M 160 does its job quite unpretentious and looks just banal, yes almost naively like a microphone. It always finds room under the snare and due to its low weight long boom arms are never critical. Its polar pattern is generally known to be helpful in representing more isolated sound sources, rear influences are present, but low enough so that they are not disturbing in some distance. The sound characteristic of the M 160 is not uniformly like an eight on the different directions of sound, but even with a moving signal it is not noticeably that strong.
Beyerdynamic's ribbon microphones are the most robust microphone of this design. The aluminium of the M 160 ribbons is rolled and becomes tear-resistant through this and the magnet consists of one casting which is to make the capsule durable as well.
The character of the microphone strongly resembles its sibling with the eight polar pattern. As the M 130 it sounds transparent, occupies signals with a very, very modest veil of dust, tames points and corners in the signal. Regarding its good nature and sound character, it counts to the more muted microphones among the ribbon microphones (...) especially when percussion is picked up. When speaking into it with a human voice, the level drop is noticeable, and of course, the microphone is also suitable for picking up a guitar amp. "
The Beyerdynamic M 160 is a ribbon microphone, which is very small and robust for this transducer / receiver type showing a restrained ribbon character - and at the same time it is not too expensive. The peculiarity lies in hypercardioid polar pattern which is unusual for a ribbon. This can be very useful on the one hand, such as when a high channel separation is required, but you have to take a certain sonic compromise. This was really excellently solved by Beyerdynamic, because with the M 160 they originated a microphone which really exists only once in this form.


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Celgosivir as a Treatment Against Dengue (CELADEN)
This study has been completed.
Singapore General Hospital
Duke-NUS Graduate Medical School
Information provided by (Responsible Party):
Singapore General Hospital
ClinicalTrials.gov Identifier:
First received: May 15, 2012
Last updated: November 28, 2013
Last verified: November 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This is a Randomized, Double-Blind, Placebo-Controlled, Phase 1b Clinical Study to Evaluate the Activity, Pharmacokinetics, Safety and Tolerability of Celgosivir in Adults with Confirmed Dengue Fever.
|Dengue Fever
|Drug: celgosivir Drug: placebo
|Phase 1 Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
|Official Title:
|Celgosivir Proof of Concept Trial for Treatment of Acute Dengue Fever
Resource links provided by NLM:
MedlinePlus related topics: Dengue Fever
Genetic and Rare Diseases Information Center resources: Dengue Fever Hemorrhagic Fever Viral Hemorrhagic FeverU.S. FDA Resources
Further study details as provided by Singapore General Hospital:
Primary Outcome Measures:
- Virological Log Reduction (Virological Endpoint) [ Time Frame: 4 days ]
- Fever Reduction (Clinical Endpoint) [ Time Frame: 4 days ]
Secondary Outcome Measures:
- Safety-Proportion of patients experiencing adverse events and serious adverse events [ Time Frame: 14 days ]The proportion of patients experiencing adverse events and serious adverse events
- Quantitative NS1 and NS1 clearance [ Time Frame: 14 days ]NS1 non-structural protein 1
- Hematology [ Time Frame: 14 days ]Leukocytes, platelets, hematocrit
- Pharmacokinetics - Clearance of drug (L/hr) [ Time Frame: 5 days ]Clearance of drug (L/hr)
|Study Start Date:
|July 2012
|Study Completion Date:
|July 2013
|Primary Completion Date:
|March 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Celgosivir
Drug: celgosivir
100 mg capsules, 400 mg loading dose 200 mg bid
Other Name: Bu-Cast
|Placebo Comparator: Placebo
Drug: placebo
Capsules of identical appearance containing starch
Detailed Description:
Patients with confirmed dengue fever who meet all inclusion and exclusion criteria will be enrolled and admitted to the Investigational Medicine Unit. Patients will be randomized 1:1 to celgosivir or placebo. Capsules of placebo or celgosivir will be administered for 5 days. While in hospital, daily clinical exams will be conducted, and blood samples will be collected for viral load, quantitative NS1, hematology, clinical chemistry, cytokine levels and pharmacokinetics (PK). Safety assessments will be conducted. At discharge on Study Day 5, patients will be asked to return on Study Days 7, 10, and 15 for blood sampling and safety assessments.
|Ages Eligible for Study:
|21 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Main Inclusion Criteria:
- Fever of ≥ 38°C of ≤ 48 hr duration.
At least two of the following criteria indicating probable dengue infection:
- Live or work in or recent travel to dengue endemic area
- Nausea and vomiting
- Presence of rash
- Aches and pains, including headache, or retro-orbital, muscle or joint pain
- Positive NS1 strip assay
Main Exclusion Criteria:
- Clinical signs and symptoms for severe dengue
- Patients with certain abnormal laboratory values
- History of presently active intestinal disorders
- Severe diarrhea
- Current usage of anticoagulant drugs
- Other clinically significant acute illness
- History of severe drug and/or food allergies
- Exposure to investigational agent within 30 days prior to study drug administration
- Clinically significant abnormal physical exam unrelated to dengue fever
- Pregnancy
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01619969
Please refer to this study by its ClinicalTrials.gov identifier: NCT01619969
|Singapore General Hospital
|Singapore, Singapore, 169608
Sponsors and Collaborators
Singapore General Hospital
Duke-NUS Graduate Medical School
|Study Director:
|Subhash Vasudevan, PhD
|Duke-NUS Graduate Medical School
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Low JG, Sung C, Wijaya L, Wei Y, Rathore APS, Watanabe S, Tan BH, Toh L, Chua LT, Hou Y, Chow A, Howe S, Chan WK, Tan KH, Chung JS, Cherng BP, Lye DC, Tambayah PA, Ng LC, Connolly J, Hibberd ML, Leo YS, Cheung YB, Ooi EE, Vasudevan SG. Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet Infect Dis. 2014 Aug;14(8):706-715. doi: 10.1016/S1473-3099(14)70730-3. Epub 2014 May 28.
|Responsible Party:
|Singapore General Hospital
|ClinicalTrials.gov Identifier:
|NCT01619969 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 15, 2012
|Last Updated:
|November 28, 2013
Additional relevant MeSH terms:
Body Temperature Changes
Signs and Symptoms
Arbovirus Infections
Virus Diseases
Flavivirus Infections
Flaviviridae Infections
RNA Virus Infections
Hemorrhagic Fevers, Viral
ClinicalTrials.gov processed this record on September 21, 2017


text:
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Size: X-Large #85585X Disney Minnie Mouse Classic Disguise Teen/Tween Child Costume
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Celebrate the crowning of royalty in style in this adorable Minnie Mouse child costume.
Our Minnie Mouse Tween/Teen child costume features a pink and white polka dot dress and matching ear headband.
Shoes NOT included.
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X-Large (14-16)
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Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
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- No Study Results Posted
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- How to Read a Study Record
Iron overload impaired growth in Thalassemia patients due to iron deposition in the endocrine glands, including the hypophysis and gonads. The issue of iron overload in Sickle Cell Anemia is recently studied more extensively and preliminary studies shows that endocrine damage is rarer in those patients.
Growth velocity was not systematically studied in patients with Iron Overload, even in thalassemia patients in spite several studies that assess the endocrine function in those patients. In Sickle Cell Patients this issue was not studied.
The purpose of this study is to assess the growth velocity in a cohort of Thalassemia Major and Intermedia patients and compare the results to another group of Sickle Cell patients, including Sickle cell thalassemia.
|Thalassemia Sickle Cell Disease
|Other: Medical Chart Summary
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:
|Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia
- Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia [ Time Frame: One year ]Analysis of Growth Velocity in Thalassemia and Sickle Cell Anemia and correlation with Iron Overload
|Study Start Date:
|January 2009
|Study Completion Date:
|December 2010
|Primary Completion Date:
|December 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Thalassemia Group
Patients suffering from Thalassemia Major and patients with Thalassemia Intermedia
Other: Medical Chart Summary
Summary of the Medical Files including annual growth velocity, endocrine function and iron overload status.
Sickle Cell Group
Patients with Sickle Cell Anemia and Sickle Cell Thalassemia
Other: Medical Chart Summary
Summary of the Medical Files including annual growth velocity, endocrine function and iron overload status.
Detailed Description:
Growth velocity, endocrine function and iron overload status will be studied in the patients that are in follow up at the Pediatric Hematology Unit, at the Ha'Emek Medical Center.
Patients who were lost from follow up or insufficient data about growth in the past will not included in the study.
|Ages Eligible for Study:
|5 Years to 45 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- All patients in follow up with available medical charts.
Exclusion Criteria:
- Patients lost from follow up or without enough data to calculate growth velocity or clinical and laboratory endocrine assessment or missing data about iron status.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00972231
|Pediatric Hematology Unit - Ha'Emek Medical Center
|Afula, Israel, 18101
|Principal Investigator:
|Ariel Koren, MD
|Pediatric Dpt B and Pediatric Hemaology Unit - Ha'Emek Medical Center - Afula - Israel
|Principal Investigator:
|Carina Levin, MD
|Pediatric Hematology Unit, Ha'Emek Medical Center, Afula, Israel
|Principal Investigator:
|Daniela Mathov, Student
|Pediatic Hematology Unit, Ha'Emek Medical Center, Afula, Israel
|Responsible Party:
|Dr Koren Ariel, Head of Pediatric Hematology Unit and Pediatric Dpt B, HaEmek Medical Center, Israel
|ClinicalTrials.gov Identifier:
|NCT00972231 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 3, 2009
|Last Updated:
|August 30, 2015
Keywords provided by Dr Koren Ariel, HaEmek Medical Center, Israel:
Thalassemia Major
Thalassemia Intermedia
Sickle Cell Anemia
Sickle Cell Thalassemia
Iron Overload
Growth Velocity
Additional relevant MeSH terms:
Anemia, Sickle Cell
Iron Overload
Hematologic Diseases
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Genetic Diseases, Inborn
Iron Metabolism Disorders
Metabolic Diseases
ClinicalTrials.gov processed this record on September 25, 2017


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VISITORS are banned from all Worcestershire hospitals following an outbreak of the winter diarrhoea and vomiting bug.
All visitors are being asked to avoid going to Worcestershire Royal Hospital, the Alexandra Hospital in Redditch and Kidderminster Hospital, NHS leaders confirmed today.
Helen Blanchard, chief nursing officer for Worcestershire Acute Hospitals NHS Trust said: "We understand people want to visit relatives in hospital but would like to remind visitors not to attend if they have any symptoms of norovirus infection such as diarrhoea and/or vomiting you are reminded to stay at home.
"There are increasing numbers of cases of diarrhoea and vomiting in the community, which is expected at this time of year. It can be very difficult to contain the spread of this extremely contagious illness but restricting visitors will have a significant impact and help prevent the spread of this illness which is unpleasant for most people but which can be a greater risk for people who are already ill."
Those with symptoms of norovirus infection such as diarrhoea and/or vomiting you are reminded to stay at home and to call a GP or NHS Direct rather than risking transmitting the infection further.
There is no specific treatment for norovirus apart from letting the illness run its course. Drinking plenty of fluids to prevent dehydration, washing hands thoroughly after using the toilet and avoiding food preparation for others until 48 hours after symptoms have subsided can help.
The latest figures from the Health Protection Agency (HPA) show there have been 3,538 laboratory confirmed cases of norovirus this season (from week 27 to week 50 2012).
The latest figures are 83 percent higher than the number of cases reported at this point last year when there were 1,934 cases.
During the two weeks up to December 23 there were 70 hospital outbreaks reported, compared to 61 in the previous fortnight, bringing the total of outbreaks for the season to 538.
The distribution of norovirus cases across the season varies significantly from year to year, but the number of cases has risen earlier than expected this year. It has not yet been determined why this has been the case, but it is a trend that has been seen across Europe and other parts of the world.


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I was wondering, does the first page has to be the home page?
For example I am designing a site where when you first load it, the main content you see are three boxes which you click on and they take you to other pages, a bit like navigation buttons, something like this wireframe:
Now ones you get deep in the website, you expect a home button to appear. I has thinking that the above design would be fantastic as the first page users see. But isn't it pointless for it to be the home page? As similar links offered in those three boxes would also be accessed from the top navigation
I have seen three boxes used in this way, but do you think having that as the homepage (people come back to) is pointless - or am I just wrong and a homepage like that is fine?
The short answer is no.
The more useful and comprehensive answer is : it should. For the sake of clarity lets call the "index." file ( which is the one that visitors WILL ALWAYS SEE FIRST) the landing page. It can be anything you want, but 9/10 is either a working page , portal to the site , about, or a "splash" about. In my experience it's about striking a balance between immediate functionality and branding potential (and is some cases advertising $$) The main issue with what you are proposing is... what if the user want to see the content that when saw when he first landed on your site? Instinctively most people will look click the site name/logo or look for a home button, but in what you are proposing this will take them to a "different" home page and not the one they arrived at... which is what they REALLY WANTED .. thus you will have a frustrated visitor. Not a good thing. If you are able to mitigate this.. then OK, but otherwise I would be seriously concerned.
Thanks, that makes sense. I had this idea at the back of my head for a long time, and it is nice to clarify it. Thanks?
Keep in mind that the page that you consider to be the "home page" or the "landing page" isn't necessarily the one that visitors will see first.
Visitors might arrive at your site by following an external link, or using a search engine, or typing a link given to them by a friend, etc. In all those cases, they are just as likely to arrive on an internal page as the home page. The important point is to make it as easy as possible for them to navigate to other pages from wherever they land. Unfortunately, your proposed design doesn't do that.
In addition, I'd argue that a good home page is one that gives an overview of what your site is all about. Your three-box design doesn't do that. "Case study", "services" and "contact" might well be the most important parts of the site, but they don't convey much when seen in isolation.
Visitors might arrive at your site by following an external link, or using a search engine, or typing a link given to them by a friend, etc. In all those cases, they are just as likely to arrive on an internal page as the home page. The important point is to make it as easy as possible for them to navigate to other pages from wherever they land. Unfortunately, your proposed design doesn't do that.
In addition, I'd argue that a good home page is one that gives an overview of what your site is all about. Your three-box design doesn't do that. "Case study", "services" and "contact" might well be the most important parts of the site, but they don't convey much when seen in isolation.
No, Its not a bad idea...
I agree wholeheartedly with Mike. Tho it's a MARKETING trend I have been seeing a lot lately, sell first, identify later. I assume this must have been the SEO guys ways of getting keywords on the landing page? but that's only conjecture.
Yes I was thinking that the first page should have more information, but from the content I got from the client, which is not enough right now. I thought that those three boxes are the only useful content to have in the homepage, as none of the content is worth having on the home page.
I thought of having some introductory content before the boxes. But really I will need to talk to the client if he has any content that we should show on the home page
The reason why I asked this question was precisely because I dont have any content for the homepage. I'll keep Mikes suggestion in mind and think whether we can add any more to the homepage.
Or I might do some research on how other sites deal with homepages where the three-boxes are present. - This was a question just for to check if I could have (essentially) two home pages. But that for this insite.
If nothing else, use the main landing page to give a clear introduction to what the site is about. It amazes me that SO many sites fail to do this. After the intro statement, you can have links to the most important content with snippets etc.
Remember that the client will most likely have a top level domain (clientsite.com) on cards and letterheads etc., so something useful needs to be presented on the main index page.
No , i don't think it is a good idea as every time it is not necessary that people will visit your site directly through search engines i.e google , they can land up to your websites through several other referrals sites . So , i won't give you advice to do so .
Is it a bad idea to have a different homepage and a different "first-page"
I remember in the days of Macromedia Flash, it was a somewhat popular to have a splash page, which took up the entire screen. It would traditionally contain the main links and advertising regions. Web designers confused the splash page with the homepage and clicking on their logo would return you to this animated page. Once you enter the website when you click on the logo you do not return to this splash page and not the homepage. Luckerly Wikipedia did not do the same mistake.
Furthermore links to this splash page internally seriously affected user experience; imagine every time you click on the logo to be directed to the heavy flash based introduction, a little annoying to say the least. Search engine optimization was also on the down as the homepage contained little to no text information about the company, instead it would contain an animated introduction created to draw existing users, but lacked in drawing in new users as it did not have the proper SEO principles to get noticed via the search engines.
Back to the original question and aiming at UX, what would the users expect when they go to your website, what would they expect to see?
The answer is your website in full, a splash page to select a country or language is acceptable, as many global websites take this approach, however, an introduction page to promote products is not going to work in your best interest, particularly as users went quick relevant information. If there is a very important notice you can easily have a pop-up appearing on your website on first load.
Your design looks good for a homepage and a first page, I would keep this as the homepage. Furthermore the home link should always be on the website, it should not appear only within deep links. This again affects user experience.
Everything has to make sense, otherwise you'd either annoy your user or loose them completely.
A particularly irritating thing about them was the redundant hyperlink saying "Click here to enter site". As if anyone would want to visit the splash screen without entering the site.
lol... -1 to user experience.
Can't imagine why anybody would want to go to a splash page, and for this reason the advertising there is really taken as an irritation rather than effective advertising, a little like the pop-up advertising, not sure on the effectiveness of those things, but I don't believe they would be very effective.
This makes my initial idea sound really stupid Now I think I just need to change the home page design. Maybe add more content before the tree boxes.
I really hope that when I meet with the client he is going to give me more content, and hopefully dont have to keep the homepage so ... pointless.
I guess it's up to you to make it clear that you can't go any further with the home page until he gives you the content. Tell him that you at least need something to start with. It doesn't have to be the final, polished copy, provided it is enough for you to make a start.
Having said that, have you got any content yet for the internal pages? Maybe you can distil some of that into a version for the home page - at least to be going on with.
Having said that, have you got any content yet for the internal pages? Maybe you can distil some of that into a version for the home page - at least to be going on with.
I have to agree wholeheardly with @Mikl; here. From experience some clients don't decide what goes on the homepage, in such cases I normally extract what's on the internal pages and put them on the homepage. I use a template, at times we have to work around client feedback, as in some cases this can be painfully slow!
I dont have any concrete content , but I am fully aware of the idea, and therefore I have enough to work on before meeting him.
He has just given me a site map of the pages he needs and few websites that are similar (in what they offer) to what his business is. So thats all I am working with at the moment
I have just started the design (a wordpress theme) so for now I can afford leaving the homepage as is and work on everything else.Because as it is only the beginning I have enough work to do. Though of course if I had the content before hand it be much easier to work with * I am sure that working the design around the content would be better than designing and the adding the content.
What I am thinking is that I leave the home page as it is. Even though it does not tell the audience what the site is about. At least it is starting to look good, and it has given me enough to work on with other pages. Then after meeting the client I can come back and change or add more content to the home page.
This is my first job with clients so I am new at what to expect from the client
I do agree with you. everyone want to go on informative page on a website when i face 'click here to enter site' page i feel so irritating i can say it is a bad idea to have different homepage and different first page.


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Kenny Dichter, founder of jet-card innovator Marquis Jet, is re-entering the private aviation market with the launch of Wheels Up, a new private members club. The new company is set to place an $800 million order for 105 Beechcraft King Air 350i twin turboprops, with deliveries of the eight-passenger aircraft due to begin in the fourth quarter of this year, running through 2018.
According to Dichter, the choice of the latest King Air model will "redefine the entry point" for private aviation service offered through a closed-fleet model. The company is also working with Beechcraft to develop customized versions of the 350i to include Wi-Fi connectivity in the cabin. Dichter said the King Air is an ideal choice, providing superior storage and range/payload compared with other aircraft.
"In partnership with Beechcraft, Wheels Up will offer the King Air 350i for the first time to consumers in a national fleet format," said Beechcraft CEO Bill Boisture. "When Kenny first informed us about his plans for Wheels Up we knew we wanted to be an anchor part of the program."
"Based on mission requirements and the need for a highly reliable platform, the King Air 350i is ideally suited to ensure the success of the business," continued Boisture. "This is a winning combination working with Kenny, who knows the front end and back end of this business. He has a feel for the experiences that his members desire, and he delivers."
Wheels Up intends to spread its fleet across seven or eight "regional clusters" in the U.S. and is in the final stages of selecting an operating partner from a short list of companies. Dichter told AIN that he is in advanced discussions with several closed-fleet jet operators with a view to a partnership that would allow its members to have access to larger, longer-range aircraft.
Dichter says he envisions a real 8,760-hour culture (referencing the number of hours in a year) for the private members club, and is also launching Wheels Down, a corresponding lifestyle concierge service arm to reach members when they aren't flying. Wheels Down members will have access to exclusive offerings such as special programs around major sporting events (for example, The Masters golf tournament and the Super Bowl), intimate concerts with top performers, culinary experiences with some of the world's top chefs, meet-and-greet opportunities with entertainers, politicians and business luminaries, among others.
Dichter predicts that within seven years Wheels Up will have a membership base of 10,000 to 15,000 individuals and corporations, flying an average of 20 to 30 hours annually. In the process, the new company anticipates that members will each spend between $100,000 and $125,000 per year, generating annual revenues of between $1 billion and $2 billion and logging at least 200,000 flight hours. The company just opened an 8,500-sq-ft headquarters in New York City's Times Square.
Dichter envisions that Wheels Up will be a "high-tech and high-touch" operation to cater to its members, modeled on the personalized service that he says became synonymous with Marquis Jet during his tenure with the company. Its services will be delivered through advanced IT infrastructure connecting with mobile devices. The new venture is developing several new applications so members can book flights, share flights and manage accounts online.
Dichter formed Marquis Jet in February 2001 when he and his team made a deal to remarket small packages of hours with Berkshire Hathaway's NetJets fractional ownership program. In November 2010, NetJets acquired Marquis Jet, which at the time had grown to include approximately 4,000 active cardholders. According to Dichter, the jet card concept revolutionized access to private aviation and he predicts that Wheels Up also will transform the marketplace.
"Twelve years on [from the launch of Marquis Jet] there is an ever-growing base of prospective customers who want the benefits of closed-fleet flying through an understandable and flexible product," concluded Dichter. "Wheels Up will seize this opportunity."
As of press time, Wheels Up had yet to publish detailed terms and conditions for the new membership program. Also still to be announced are details of what Dichter said will be a "prestigious" management team that "aims to transform the private aviation industry again."
Watch Kenny Dichter's interview about Wheels Up on CNBC this morning.
King Air 350i By the Numbers
Max cruise speed 313 kts
Max range with four pax 1,714 nm
Max operating altitude 35,000 ft
Takeoff field length (mtow) 3,300 ft
Landing field length (Mlw) 2,692 ft
Max payload 2,500 lb
Mtow 15,000 lb
Engines PT6A-60A, 1,050 shp each
Avionics Rockwell Collins Pro Line 21
Pax load, typical configuration Pilot + 9
Cabin length 19 ft 6 in
Cabin width 4 ft 6 in
Cabin height 4 ft 9 in
Baggage capacity 71.3 cu ft
George Bragg lll (not verified)
August 3, 2013 - 2:13pm
Dear Sir,
I would like to be at the start up of Wheels up. I am a retired pilot for FedEx which I started in the Falcon days.
Also, I have 3 deployments in Iraq and 7 deployments in Afghanistan in the
KA-350. I was a IP and a FCF IP with L-3 Communications with over 2,400 Hrs.
in country.
George Bragg lll
Gene Poore (not verified)
August 19, 2013 - 8:49am
Why buy a King Air 350 instead of a 200 because a 350 requires a type rating and often two pilots which makes a 350 less desirable in resale market to small companies or individuals who have a smaller pool of qualified free lance pilots to choose from which often requires the owner to pay $25,000 for a type rating for new part time pilots who often quit for a better full time pilot job?
Capt. Denis Murphy (not verified)
September 6, 2013 - 7:33am
Where can we email the CV for the upcoming pilot positions?
Kenny Bacheller (not verified)
September 10, 2013 - 5:42pm
Dear Mr. Dichter, When will your company start hiring for "Wheels UP". I flew you a couple of times when you and Mr. Santulli were still associated with "Netjets" I'm currently still at Netjets, but have an interest in "Wheels Up" Cheers Kenny Bacheller


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The city of Los Altos officials today (Nov. 19) announced dates for construction-related closures over a five-week span along First Street – including one already underway.
Construction at 400 Main St., 100 First St. – as well as the ongoing Safeway reconstruction project – will require temporary street or lane closures that will vary from one to five days, according to Los Altos Public Information Coordinator Erica Ray.
Ray noted that closures will occur no earlier than 7 a.m. and must end by 5 p.m. each day. She added that each project's specific closures within the daily timeframe could vary. Ray said the schedule (listed below) is subject to change due to poor weather and other factors.
400 Main St.
• Saturday, Nov. 23
• Monday, Nov. 25
• Tuesday, Dec. 10
Closure of the street will occur between State Street and Parking Plaza Central. Access to the Parking Plaza from Main Street will not be blocked.
100 First St. (condominium project)
• Monday, Dec. 2
• Wednesday, Dec. 11
• Tuesday, Dec. 17
Lane closures will be required in front of the project parcel. Flagmen will be present to enable through-traffic to proceed on the street.
Safeway project
• Street closure: Nov. 18-22
• Lane closure: Dec. 18-19
Street closure for this project is underway between State Street and Plaza North. Motorists will have access to Public Parking Plaza 7 from the W. Edith Avenue direction. In addition, the project will require a lane closure in the central portion of the Safeway parcel along First Street. According to the city, through traffic on First Street will be allowed during that time.
In addition, the city has also approved a three-hour street closure Tuesday, Dec. 3, at 235 First St. to allow retail store Land of Nod to move into its new location. According to Ray, the closure will occur in the early morning or evening hours in an effort to avoid conflicts with other construction traffic in the area.


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Dinner Quick: Pasta with Feta, Broccoli, and Sausage
We have a little formula in our kitchen for quick dinners. (Have you figured it out yet?)
That would be pasta, greens, meat, and cheese. All the food groups in one!
And this week we had a particularly good block of cheese: the local artisan goat cheese we've been spotlighting in recipes all this week. And if there's one thing we know about feta, it's that it goes awfully well with broccoli.
So we tossed together some steamed broccoli, the amazingly rich and complex feta, and some already cooked smoked sausage. Smoked sausage is one of our favorite ways to add just a little meat and flavor to our one-dish suppers.
Cook all that together, let it get a little crispy around the edges (like our recent pan-fried butternut squash pasta), and all the flavors come together quickly into a very easy, very fast one-dish meal.
(And yes, we may be preaching just a little, but that local feta really put it over the top.)
Pasta with Feta, Broccoli, and Sausage
1 pound penne pasta
1 small head broccoli
Olive oil
2 cloves garlic, minced
1/2 pound smoked sausage like kielbasa or andouille, sliced
4 ounces fresh feta, chopped or crumbled
Salt and pepper
Cook the penne pasta according to package directions. Drain and set aside. Meanwhile, cut the broccoli into small florets. Set aside the woody stalks for another use. Heat about 1/2 cup water in a large sauté pan over medium heat. Add the broccoli florets and cover. Steam for about 6 minutes, or until barely tender. Remove broccoli and discard any extra liquid.
Heat a little olive oil over medium heat in the sauté pan and cook the garlic until golden and fragrant - about 2 minutes. Add the sausage and cook, stirring frequently, until hot.
Turn up the heat to medium high and add the broccoli, pasta, and feta. Cook, stirring frequently, until all is hot and the edges of the pasta are starting to crisp up. (Note: Do in batches, if necessary.)
Taste and season with salt and pepper.
Related: Recipe: Penne with Acorn Squash and Pancetta
(Images: Faith Durand)


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Shipping Soon. New Production Photos...
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums. To buy action figures, take a look at BigBadToyStore.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.
The second series of Street Fighter X Tekken Minimates is fighting its way to stores now, featuring some of the biggest names in both franchises. Each mixed two-pack includes two Minimates, one from the Street Fighter universe and one from Tekken, each standing 2 inches tall with 14 points of articulation. Look for them in comic shops and specialty stores on January 2nd, and at Toys "R" Us soon afterwards, with exclusive characters at both locations. Check out the pics of the final product below.
Comic and specialty shops will get:
Ryu vs. Yoshimitsu
Abel vs. Kazuya
Hugo vs. Heihachi (exclusive)
Rolento vs. Kuma (exclusive)
Toys "R" Us and toysrus.com will receive:
Ryu vs. Yoshimitsu
Abel vs. Kazuya
Rufus vs. Julia (exclusive)
Chun Li vs. Hwoarang (exclusive)