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Beng Geok Wee; Ivy Buche
|Format: Hardcopy Black & White
|Also Available In:
|English PDF
|List Price: $7.46
|Source: ABCC at Nanyang Tech University
|Publication Date: Oct 23, 2008
|Product #: NTU015-HCB-ENG
|Discipline: Service Management
|Length: 22 p, English Hardcopy Black & White
By 2008,Aitken Spence Hotel Holdings PLC (ASHH), a leading Sri Lanka hotel group had established a reputation for operating iconic resorts, in particular, its resort at Kandalama in the central highlands region of the country. Heritance Kandalama, the resort, had evolved after a troubled beginning to gain international recognition for its social, ecological and environmental best practices. In large measure, this was due to the emergence of a set of people management practices that had evolved an organizational culture with values that supported these best practices and enabled the resort to survive, notwithstanding ongoing civil conflict in Sri Lanka. In 2007, ASHH launched a strategic drive into hotel management services in India. A major element of the group's brand equity was its core competency in sustainable and community-sensitive development, much of which it had acquired through the Heritance Kandalama resort experience. A key challenge for ASHH: Can the group's philosophy of sustainable development be successfully implemented in India's hospitality industry? How could ASHH use the Kandalama experience to manage hotels in the culturally and socially diverse towns and cities of India?
The case illustrates strategy formulation for expansion and diversification by leveraging on its value proposition of sustainable development as well as the Heritance brand. Key issues confronting Aitken Spence that could present challenges during implementation are also highlighted.
Branding; Diversification; Growth strategy; International business; Service management; Strategy; Sustainability


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2013 Ethnic Contender Membership, Gold Award Pin
CHOKING HAZARD -- Small parts.
Not for children under 3 yrs.
Your Comments!
What I like the most about Keepers is that it is a Biblically based program with sooooo many fun things to learn and do. My daughter had wanted to join girl scouts (mainly because some of her friends from church are girl scouts and she thought she was missing out) but I felt convicted not to allow that so I was thrilled to start Keepers instead!

subset: commoncrawl


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Hard Work Paying Off As Lafayette Little League Prepares For Junior League World Series (Audio)
The Lafayette Little League Junior All Stars (13-14 years old) is making a special trip this weekend, as they head to Detroit (area) for the Junior League World Series all next week. They've just come off of sweeping two Texas teams (Texas West and Texas East) in the Southwest Regional Tournament in Albuquerque, New Mexico, holding on in the championship game by beating Texas West 8-6.
The team is made up of 11 players: Tyler Miller, Cain Castille, Emile Lege, Miguel Reyes, Nick Fruge, Brandon Duhon, Matthew Delcambre, Max Jumonville, Mike Guidry, Colin Thibodeaux, and Ethan Hines. The coaches are Kevin Delcambre, Greg Guidy and Nick Fruge. Head Coach Delcambre visited with Brandon Comeaux on "Your Afternoon Drive Home" to talk about his team's ride to the Junior League World Series.
It's exciting. This is a rare thing. There's a lot of teams that start out and it's a hard road to get to the World Series…It's a special trip and we're going to make the most of it.
Head Coach Delcambre also praised his assistant coaches for the job they've done in helping this team accomplish this special feat. "All the coaches have been great," says Coach Delcambre. "They've put in a lot of hard work. We've put in a lot of practice, spent a lot of time on the practice field…We've been putting the work in and the coaches have done a great job at doing that."
Coach Delcambre says on Friday evening, after arriving in Detroit, the team had their first practice since they won the Southwest Regional earlier this week. This Lafayette Little League team has hit very well throughout state and regional tournament play. They have been able to get on base, and then once they get there, are very tough to stop on the base paths. "This is the fastest team I've ever coached," says Coach Delcambre. "We have a lot of speed…It puts a lot of pressure on the opponents when you have that kind of speed." Coach Delcambre then addressed how balanced the lineup is. "The whole lineup is doing a job hitting and every kid on this team is contributing, every one of them is playing a major role to getting us to where we are," says Coach Delcambre.
Five of these players have played in a Little League World Series before, representing Lafayette Little League in the 2011 Little League World Series (11-12 year olds). When you combine that with the talent of the other six players, the maturity in age of the team overall and learning from playing great teams last season, Coach Delcambre says they went in very confident this season. "Going in this year, we were confident because we were built the same way they (two Texas teams from last year) were," says Coach Delcambre. "We were an older team."
Lafayette opens tournament play Sunday at 4:30 p.m. vs the representative of US Central. The team will play three other pool play games, Monday at 10:00 am vs US East, Tuesday at 1:00 p.m. vs US Southeast and Wednesday at 7:00 p.m. vs US West. The top two teams in the US pool will advance to the US Championship Game on Friday night at 7:00 p.m. All games can be heard on Sportsradio ESPN 1420 AM and espn1420.com. James P. Bitterman will have the call.
These trips are very expensive. If you would like to help the LLL All Stars and their families with the costs of these trips, click HERE.
To listen to Coach Delcambre's interview, CLICK BELOW:


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Black, Padres prep for upcoming Interleague games
SAN DIEGO -- Beginning Friday, Padres manager Bud Black will be allowed to add an extra hitter to his lineup, with the team playing the first of five consecutive Interleague road games.
The Padres play three games against the Rays and two more against the Orioles, part of 10 Interleague road games this season that will allow for the team to use the designated hitter.
"It's an opportunity for us to get another bat in the lineup. We like our bats," Black said.
Last season, the Padres didn't get much production from their designated hitters -- .235 batting average with four hits in 17 at-bats with one home run and two RBIs.
Black said that you can expect to see outfielder Carlos Quentin get several starts as the designated hitter as it will allow the team to continue its plan to give Quentin and his surgically repaired right knee a rest from playing in the field.
"We have to manage this for six months," Black said of Quentin's knee.
By using the designated hitter, the Padres will lose one option from their stable of bench players, though Black isn't too concerned about being short-handed.
"The thing with an American League game, with the DH, that guy is pretty stable in there the whole game," he said. "The flexibility you need to have in an NL game, you need extra players and versatile players. The AL game is pretty straightforward."
The Padres play two Interleague road games in Seattle on May 27-28. The team will then play a three-game series in Boston, July 2-4.
Corey Brock is a reporter for MLB.com. Keep track of @FollowThePadres on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.


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frank & jan is a design company that first and foremost makes art. The design team ingests multitudes of pop culture imagery and fabricates its own graphics using familiar images in new ways. They are focused on capitalism, fame, minimalism, and consumption and find these themes in the various images they utilize to create their aesthetic. Once they have come up with the ideas necessary to make a streetwear line, they execute their brand of artwork flawlessly onto various articles of clothing. frank & jan clothes are just a canvas to showcase the designers' artwork and, fortunately, the artists are constantly inspired by the world around them.
No products match your selections. Try clearing your filters.


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Topic: Initial post
Hi. I came across your foundation website when I began my research into intrahepatic cholangiocarcenoma. My wife was just diagnosed with ICC. We have not started treatment yet but the course laid out for us is chemo (gemcitabine/cisplatin) and then radio-embolization.
As with many others posting, this was an absolute shock as she is very healthy, active and very health conscious. She always goes to doctors for care and for maintenance procedures.
We live in Eastern US and are planning to get consult visits at a few cancer centers, including Sloan and U. of Penn. Trying to set those up now.
We are also going to pursue clinical trials if she is a candidate.
Right now our heads are spinning. But we are preparing for battle and have a great support group of friends and family.


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Request More Information From Any of the Schools Below.
Programs Offered:
100% Online & No Standardized Testing
Regent University prepares students with the knowledge to excel and the faith to live with purpose.
Congratulations! Your interest in Independence University is an important first step toward changing your life. A career-focused degree is the key to a career with a potentially higher income, better benefits, and more satisfaction.


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Pay it OffLogic puzzles require you to think. You will have to be logical in your reasoning.
Using only three bills, and not using a $10 bill, how can you pay a person $35 that you owe?
HintThe three bills are two $20s and a $5 bill.
AnswerYou pay the person $40 using two $20 bills. Then the person pays you back $5, using a $5 bill. You paid $35, and three bills were used.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
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text: Pet Paint for Dogs is professional quality spray paint for dog fur. Safe for dogs, do not use on birds or reptiles. For dogs with a dark coat, spray a base coat of white, then spray on the desired color. For detailed work a stencil is recommended. Washes out with shampoo.


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Alumni Happy Hour featuring the UB deans as guest bartenders
- When:
- Location:
- Off Campus
- Description:
PLEASE NOTE: This event has been rescheduled for Wednesday, April 24 due to the forecasted winter weather advisories.
Visit www.ubalt.edu/alumnihappyhour for more information.
- Contact Name:
- Office of Alumni Relations
- Contact Email:
- email@example.com
- Contact Phone:
- 410.837.6131
If you need accommodations to participate in this event, please contact the person listed above at least 10 days prior to the event.


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NEWPORT County AFC manager Justin Edinburgh admits he has a tough decision to make ahead of today's clash with Lincoln City – whether to change a winning team.
New signing Mike Flynn is pushing hard for a starting place having overcome a bout of sickness and he played 20 minutes as a substitute in Tuesday's 4-0 hammering of Nuneaton Town.
But Edinburgh is reluctant to change a starting XI that has scored eight goals in two games and fired the Exiles to the top of the Blue Square Bet Premier.
"Everyone is fit now, apart from Alan Julian," said Edinburgh.
"Flynny has not had a full week of training yet but he's ready to go so I have a decision to make.
"But it would be very difficult to leave out anyone after the first two games because we've been excellent.
"That just shows you the strength of the squad now because people like Lee Minshull, Jake Harris and Ryan Charles are waiting for their chance and their time will come."
One man who doesn't have to worry about his place today is Jefferson Louis, who scored at Mansfield last week and against Nuneaton.
The 6ft 2ins striker was at Lincoln last season and was a key factor in the club's bid to avoid relegation under manager David Holdsworth.
Finances dictated the Imps could not keep hold of him in the summer and their loss has been County's gain.
The task of manacling him today falls to Lincoln defender Andrew Boyce, who scored in Tuesday's 2-1 defeat at Cambridge United.
The towering centre-back played alongside Louis when they were at Gainsborough together and he knows what his old teammate has in store.
"He is going to want to smash me up a bit, but I would not expect anything less from Jeff to be honest," he said.
"If he is on your team then he is brilliant to have because defenders hate playing against him because he is so physical.
"He is a very good player. He came to Lincoln and was magnificent but I am ready for him. I am sure there will be a lot of banter between us, but I am relishing the challenge."
The visitors are likely to have several familiar faces in their squad.
Defenders Paul Robson and Tom Miller and striker Rob Duffy could all feature against their former club.


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A winter warming spell continues Friday as Orange County wraps up the workweek, with inland highs again reaching for the 80-degree mark, the National Weather Service says.
But the warm, dry weather that has dominated much of the week, pushing several inland cities into the low 80s Thursday, must make room for thickening clouds through the weekend.
And colder weather could return by Thursday, possibly bringing rain along with it by this time next week.
It's the usual story of high- and low-pressure air. High pressure over the region has been driving the warming, but high clouds filtering in this weekend will be the work of a low-pressure system moving in from the southwest.
Stronger low pressure expected late next week is prompting predictions of a turn toward the cold.
For now, the postcard weather continues.
Monday looks mostly sunny and 75 to 80 inland, 65 to 70 on the coast.
Saturday through Thursday should be partly cloudy, and while temperatures retreat a little, we should stay mostly in the 70s through early next week.
Inland highs should be 76 Saturday, 74 to 79 Sunday, 72 to 77 Monday and 67 to 72 Tuesday.
On the coast it's 64 to 69 Saturday, 68 to 73 Sunday, 66 to 71 Monday and 62 to 67 Tuesday.
Wednesday still looks fairly mild – 63 to 68 inland, 61 on the coast – as low pressure approaches from the Gulf of Alaska.
Then Thursday's highs dip noticeably into the 59 to 64 range.
The long-range look suggests a chance for rain Friday and Saturday.
Despite recent rains, Orange County and the rest of Southern California remain well behind in rainfall.
Santa Ana saw 4.3 inches of rain from July 1 to Jan. 31, the Weather Service says, though the 30-year normal amount is 7.28.
Share your weather photos:
Send your recent, Orange County weather photos to email@example.com along with your name, home city, when and where the picture was taken and what it shows.
We publish many reader photos online and in print.
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Sewer Rates and Billing
Billing policies and sewer rates are established by the Board of Supervisors as prescribed by Article 10, Chapter 67.1 of the County Code. Rates and code language are reviewed annually by county staff as part of the county's annual strategic planning and budgeting process and revised as necessary. Following are specific billing practices:
Residential customers are billed for use of the sanitary sewer
system based on water consumption during the current billing period or
the preceding winter quarter billing period, whichever is lower. This
prevents residential customers from being charged for sewer use on
water used outdoors during the summer.
Residential customers who use the county's sanitary sewer system, but obtain water from a well, are charged based on the number of persons residing in the home.
Commercial customers are billed for sewer use based on their
actual water consumption. Some commercial customers use meters to
separately measure water that does not drain to the sanitary sewer
system, such as water used for irrigation or cooling systems. These
metering arrangements do not benefit residential customers, whose
winter quarter water consumption limits the amount of sewer usage
billed in the summer months.
Commercial customers who use the county's sanitary sewer system, but obtain water from a well, are charged based on the number of fixture units in the commercial building.
A Sewer Base Charge, for all customers, became effective with the billing period beginning July 1, 2009. The base fee is to partially recover fixed expenses for billing, wastewater collection, engineering, planning and administration.
Sewer service charges are billed and collected in quarterly combined water and sewer billings through three water billing agents. To establish a sewer billing account contact the appropriate water supplier:
- Fairfax Water, 703-698-5600, TTY 711
- City of Falls Church, 703-248-5071, TTY 711
- Town of Vienna, 703-255-6385, TTY 711
Contact the Wastewater Planning and Monitoring Division at 703-324-5015, TTY 711, with questions regarding sewer service charge rates and billing.


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Kiln Dried Solid Domestic Hardwoods
Authentic Amish Construction
Made in America
Our Amish 3-in-1 High Chair, shown here in Red Oak with Natural finish, is beautifully handcrafted by Amish craftsmen in Indiana, employing age-old practices. Our 3-in-1 High Chair is made entirely of kiln dried solid wood, grown & harvested responsibly within a 250 mile radius of our builder's workshop. With just one turn it goes from high chair to rocking horse & another turn and it becomes a writing desk. Safety belt included.
- Hand made in the USA
- Kiln dried solid hardwood
- Materials sourced domestically
- Veneer free
- Plywood free
- Particle board free
- Pressed wood free
- MDF (Medium Density Fiberboard) free
- Approximate dimensions: 13" x 19" x 32"
- Available in Standard and Wide (approximately 4" wider than Standard)
* Each item is custom made to order & may take 6-8 weeks to complete, plus packing/shipping time
* ETAs vary by season; please email us for current estimate
* Our products ship only in the contiguous USA
* Free Shipping is a curbside only service. It is not Inside Delivery
* Inside Delivery (room placement, assembly & debris removal) is available. Contact us for a quote if interested
* Items may vary slightly from images above
©2008-2017 Baby Eco Trends, LLC | Site Updated September 20, 2017 | info {at} BabyEcoTrends {dot} com


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Photo Flash: New Photos of Shattered Globe's MILL FIRE
Shattered Globe Theatre concludes its 22nd season with Sally Nemeth's searing drama MILL FIRE, directed by Producing Artistic Director Sandy Shinner, playing through June 7, 2014 at its new artistic home Theater Wit, 1229 W. Belmont Ave. in Chicago. Tickets for MILL FIRE are available at www.theaterwit.org, in person at the Theater Wit Box Office or by calling (773) 975-8150.
MILL FIRE will feature Shattered Globe Ensemble Members Rebecca Jordan (returning to Chicago after ten years), Kate LoConti, Drew Schad, Angie Shriner and Kevin Viol with Ken Bradley, Daria Harper, Darren Jones and Deanna Reed-Foster.
Sally Nemeth''s MILL FIRE takes audiences to Birmingham, Alabama, circa 1978. As the town struggles to mourn the loss of several factory workers in a mysterious accident, widow Marlene refuses both the pressure to grieve as convention dictates and the blood money offered by the mill''s owners. With an ever-shifting temporal landscape that shapes the story through flashback and memory, a Greek chorus of fellow widows, and emotionally charged familial subplots, MILL FIRE examines the many definitions of sorrow and the complexities of moving on.
"The characters of Mill Fire are classic Shattered Globe roles. They're passionate and complex people wrestling with ethical issues while their backs are up against the wall," comments director Sandy Shinner. "Mill Fire explores a community who fears their livelihood is about to slip away. Initially divided by blame and grief, they eventually summon the strength to come to a place of understanding, love and, finally, forgiveness."
The production team for MILL FIRE includes: Jeff Bauer (scenic design), Sarah Jo White (costume design), Charlie Cooper (lighting design), Christopher Kriz (sound design), Vivian Knouse (props design), Susan Gosdick (dialect coach), Kat Warner (production manager), Amanda Rozmiarek (technical director), Jeffrey Clark Stokes (stage manager) and Rosie Chevalier (producer).
Photos by Michael Brosilow
Kevin Viol, Daria Harper, Deanna Reed-Foster and Kate LoConti


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WXYZ reports that L'Anse Creuse High School in Harrison Township was evacuated after a man wearing camouflage and a black vest was seen entering and leaving the school around 6 a.m. Tuesday. The school is no long on lockdown.
WWJ reports the 21-year-old man is an ex-student and current airman at Selfridge Air National Guard Base. He was said to be at the school to talk to a school counselor about getting a letter of recommendation for a job. He was roaming the halls searching for the counselor when a custodian spotted him. He just got out of work, which is why he was wearing the uniform.
Fox 2 reports he was not armed, and the Macomb County Sheriff said it was bad judgement to wear the attire into the school.
The students at the school were evacuated to a nearby grocery store.�Graham Elementary and L'Anse Creuse Middle Central schools are closed for the day, but officials say this was because of a building problem not because of the man.


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Sleep Sayings Needlepoint Pillows
No longer available
- Overview
From early birds to night owls, our needlepoint pillows have got you covered.
- 7 x 15"
- Wool/cotton blend exterior with wool/cotton needlepoint embroidery.
- Embroidered by hand.
- Embroidery reads Lights Out, Early Bird or Bed Head.
- Reverses to solid white fabric.
- Polyester fill.
- Imported.
- Dimensions + Care
- Overall fabric is 74% wool, 23% cotton, 2% other fibers.
- Spot clean with a damp white cloth.
- Blot to remove excess water.
- Air dry.
- Shipping Info
This item will arrive in 3-5 business days. Please proceed to the Payment & Review page of Checkout for a precise delivery estimate.


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Note: This item is more than 11 years old. Please take the publication date into consideration for any date references.
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News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
Feb. 6, 2006
TPWD Game Warden Field Notes
The following are excerpts from recent Texas Parks and Wildlife Department law enforcement reports.
It was a net loss — On Jan. 26, game wardens from Starr County and McMullen County stopped a Mexican commercial fishing vessel on Falcon Lake. Two subjects were apprehended and approximately 2,000 feet of gill net were seized. A 17-foot boat and motor were also seized. The same day, game wardens from Zapata County and Jim Hogg County apprehended a Mexican commercial fishing vessel on the same lake. Two subjects were arrested and approximately 2,000 feet of gill net were seized. An 18-foot boat and motor also were seized.
Easier than fishing — On Jan. 24, the Midland office received several calls complaining about a woman with a dip net at Beal Park taking trout. A Midland County game warden headed to the community lake but did not locate the woman. Several witnesses who had seen the woman wrote down the plate number to the vehicle she was driving, and the game warden located the woman at her house where he observed her beheading and gutting fish. The woman had 14 fish in her possession, had no fishing license and used the dip net to capture the fish. She claimed that she did not know it was against the law to use a net, even though several witnesses said they told her it was illegal. She received a citation for taking fish with illegal methods.
Oh, y'all have game laws here? — On Jan. 22, Tarrant and Wise County game wardens teamed-up to patrol southern Wise County for waterfowl hunters. After hearing numerous shotgun blasts coming from a sandpit located about a half-mile from a county road, the wardens entered the property on foot, initiating contact with the hunters. Upon completion of the contact, the wardens found numerous violations including possession of lead shot, exceeding the daily bag limit of redhead duck, and exceeding the daily bag limit of duck. The hunters were found with a total of 17 ducks, five of which were redheads. Appropriate citations and restitution are pending.
And they apply to out-of-state hunters, too? — On Jan. 20, a Calhoun County game warden teamed-up with a United States Fish and Wildlife Service special agent and arrested six Delaware hunters involved in multiple waterfowl hunting violations near the Guadalupe Delta. The arrest resulted in 32 citations for taking geese in closed season, over the limit in ducks, possession of toxic shot shells, and no non-resident hunting licenses or waterfowl stamps. Criminal cases will be filed in the federal court. Restitution will be filed with the State Attorney General's Office for the birds.
Honestly, we're just bad shots — On Jan. 21, a Montgomery County game warden was working an area where he believed some hunters had been hunting roosting wood ducks. Sure enough, right at dusk the shots started. Dean apprehended two men for hunting after hours. The two men had two ducks. They said it was because they were not good shots, and they had probably killed most of the birds in the area on previous hunts. Cases are pending.
Just say "no parking" — A Lampasas County game warden located a vehicle parked alongside the roadway near the Lampasas River. Unable to locate the driver in the riverbed, the warden requested a deputy to stand-by while he attempted to find the driver, suspected of trespassing. The deputy happened to be a K9 officer and after the officers discussed the truck and location, both decided that the dog should make a trip around the vehicle. The K9 alerted on the vehicle, and Hill was able to locate the female driver trespassing on the adjacent property. After a search, 10 grams of methamphetamines, less than 2 ounces of marijuana, pipes, syringes, razor knives and other drug paraphernalia were found in the truck. The suspect was transported to Lampasas County Jail and second-degree felony charges are pending along with existing pending drug charges from Travis, Bell, and Bastrop counties.
Busy New Year's — On Jan. 1, at approximately 2:00 p.m., game wardens from Clay, Montague and Wise counties were requested to assist the Montague County Sheriff and area fire departments in an attempt to evacuate the public from area residences that were potentially in the path of a large prairie fire. With wind gusts up to 50 mph, the fire quickly spread from Clay County into western Montague County. By the next day, the fire had destroyed approximately 51 homes, and numerous barns, livestock, game animals and birds. Approximately 65,000 acres were destroyed.
Wake-up call — On Jan. 1, an Angelina County game warden filed charges on two local men for Class A hunting without landowner consent. The first suspect was found passed out in the road ditch on a farm road with his girlfriend. When the first suspect was awakened, he advised that his buddy and the buddy's girlfriend were stuck on a logging road. The buddy and his girlfriend were located, and they had two loaded shotguns with buckshot and a "plugged-in" spotlight.
That's a mighty big varmint — An Ellis County game warden was ending an investigation in Jan. that included hunting without consent when three pregnant cows were found dead on the landowner's property. Multiple interviews showed two subjects at the location the night the cows were found. The game warden interviewed both; they denied being on the property that night or killing the cows. The subjects did confess to hunting hog and varmints there the day after without permission. The game warden received warrants for both subjects; they were arrested and interviewed by sheriff's office investigators about the cows. The subjects denied killing the cows until they were told a vet had removed the heads of the cows with the bullets in them to match the gun the warden had recovered for evidence. Both suspects confessed and wrote statements that they were varmint hunting when they saw eyes shine in their spotlights and realized too late that what they had shot were not varmints. Both subjects paid restitution over $2,000 to the landowner, and misdemeanor criminal mischief charges and hunt without landowners consent charges were filed.
Owl catches woman — On Dec. 13, an Irion County game warden received an urgent call from the sheriff's office stating that they had received a 911 call from a woman requesting a game warden. The caller reported that she had stopped on the roadside to assist an injured owl, and the owl had attacked her and now had its talons impaled in her leg and would not turn loose. The game warden called the woman and instructed her to place a towel or cloth over the owl's head, try to remain calm and quiet and maybe the owl would release its hold. When the game warden arrived, he found the woman and her five children in the vehicle, but the owl had left the area. The grateful woman stated that she had done as instructed, the owl released its hold, and she kicked it into the ditch. The warden then advised her to get prompt medical attention for her wounds. The woman stated she would and that she would never touch another wild animal.
Freezer burn — On Dec. 17, a Bowie County game warden received a call from the Arkansas Game & Fish Commission that they had information on an illegal deer from their state that had been brought to Texas. The warden and an Arkansas warden located the residence and made contact with the owner. The owner stated his son had killed deer in Texas but not Arkansas. The father showed the officers two bucks in the freezer. They were whole, un-skinned and frozen solid since Thanksgiving. The father stated his son had killed one and his 5-year-old granddaughter killed the other around 8 a.m. on Nov. 24. The Texas warden checked for a hunting license through Houston communications, and it showed the son had bought a license Nov. 24 at 10:17 a.m. The Texas warden had the man contact his son. The son arrived and admitted to killing both deer and not tagging them. The son also stated that he had bought the license after the deer were killed. Citations were issued. The wardens had a hard time getting the deer out of the freezer because they were frozen together and to the freezer itself. After an hour of pouring hot water and also trying a water hose running on the deer, they still would not move. The son tied a chain around the deer being seized and tried pulling them out of the freezer with his vehicle, but no luck. That's when the homeowner got on his tractor, and with the use of the front-end loader, chain, both officers, and his son lifted the frozen deer out and into the bed of warden's patrol vehicle.
Tip: don't poach in front of the warden's house — On Dec. 11, a Shelby County game warden met a small pickup on a state highway just south of the warden's residence. There was nothing odd about the vehicle, but the warden continued to watch it in his rearview mirror. Shortly after it passed, the warden noticed the driver-side mirror appear to "light up." The warden quickly turned around and caught up to the vehicle, which now had a light out each window, one of which was shining into the warden's father-in-law's pasture. A .30-06 rifle, a 12-gauge shotgun and three lights were found in the vehicle. The suspect quickly admitted that he had been traveling the highway to get to work in the early morning hours and had repeatedly seen deer there and wanted to shoot one. Case pending.
What caliber arrow was that? — On Dec. 8, a call was received from a deer processor stating that a deer that had been taken the previous night needed to be inspected. The processor stated that he thought that the deer could have been taken illegally. Grayson County game wardens inspected the deer. A large hole in the back of the deer's head was observed. The wardens put a hold on the carcass and took the head to a local taxidermy shop where an autopsy was performed by an experienced wildlife surgeon. After several attempts, a large slug was removed from the deer's head. Grayson County is an archery-only county, making this an illegal kill. Upon interviewing the suspect, he admitted to killing the deer with a 12-gauge slug. The deer scored 161 5/8 Boone & Crockett. Case pending.
Wardens to the rescue — On Nov. 24, a Delta County game warden and a Hopkins County game warden rescued three duck hunters on Cooper Lake when their boat capsized. One of the hunters was disabled and was being held with only his head out of the water by the other two hunters. All hunters were rescued, along with the hunter's wheelchair. It was a day of Thanksgiving for all.
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(5.4.16 i)


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This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
Hyde Park Apartments4 Self rated
8 Craven Hill, London, W2 3DS
Price FromView Rooms
This hotel doesn't have any reviews yet.
About the hotel
Just 300 metres from Hyde Park, Hyde Park Apartments are a 5-minute walk from Lancaster Gate Underground Station. The cosy apartments feature stylish decor, modern kitchens and Wi-Fi access.
Hyde Park Apartments each have a luxury bathroom with a walk-in shower.
There is also a compact living area with a flat-screen TV, and a separate bedroom or open-plan sleeping area. With bare wooden floors and a contemporary design, the Hyde Park Apartments feature compact kitchens and dining areas. Full kitchenware is provided.
In the heart of prestigious Paddington, the apartments are a 15-minute walk from Notting Hill. Lively Oxford Street is a 20-minute walk, and Paddington Railway Station is just 500 metres away.
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U.S. corn futures are expected to open lower Wednesday on harvest pressure and questions about demand.
Chicago Board of Trade futures are called 3 cents to 5 cents lower. In overnight trade, corn for September delivery was down 2 3/4 cents to $7.06 1/2 per bushel while December corn, the most active contract, was down 4 1/2 cents to $7.18 1/2.
The market fell more than 3% Tuesday amid questions about demand and scattered reports that yields in some areas were better than expected. The retreat in prices, following a Monday government report that lowered corn demand projections, prompted more selling by traders worried the market would continue to slump, analysts said.
"It's kind of like a snowball that gets rolling down the hill," said Jason Britt, president of Central States Commodities.
Some farmers in parts of Iowa and Illinois have reported corn yields better than they expected, analysts said.
Such reports are "certainly a caution flag for the bulls," MF Global broker Joseph Vaclavik said in a report to clients.
"Many may be inclined to step aside until we know more about the crop," he added.
But Britt said such reports are scattered, and that even in those cases, farmers aren't "knocking it out of the ballpark" with their yields. Yields are still substandard, he said, just not as bad as some had expected. He added that these yield reports are based on early-planted corn, which likely has better yields. Much of this year's corn crop was planted later than normal.
Britt expects prices to open lower Wednesday, but thinks losses will be limited by an emerging frost threat in the far northwest corn belt. Forecasts are calling for a potential freeze in parts of Minnesota and the Dakotas Thursday morning.
Damage from a frost or freeze would have a bigger impact than usual, Britt said, noting that U.S. corn supplies are already projected to remain tight through next year.
But demand uncertainty looms over the market. The U.S. Department of Agriculture's Monday report lowered demand projections for ethanol, exports and feed, reaffirming concerns that buyers are less willing to by corn at prices approaching $8 per bushel.
Meanwhile, the harvest is picking up speed, which is adding more supplies to the pipeline and weighing on prices, traders said.


text:
In an Alzheimer's disease (AD) study, researchers measured signs of inflammation and blood levels of vitamin B12 in 271 adults, aged 65 to 79, who did not have dementia at the start of the study. After 17 years of follow-up, doctors found two strong links: as levels of the inflammatory protein homocysteine rose, so did chances of AD, and as vitamin B12 levels increased, chances of AD decreased.
Vitamin B deficiencies can cause high homocysteine levels. The scientists said that older adults are often low in vitamin B12 and suggested more study to confirm that vitamin B12 helps protect memory.


text:
A Health Economic Trial in Adult Patients Undergoing Open Colectomy MA402S23B302 (IMPROVE-Open)
This study has been terminated.
(Slow enrollment.)
Pacira Pharmaceuticals, Inc
Information provided by (Responsible Party):
Pacira Pharmaceuticals, Inc
ClinicalTrials.gov Identifier:
First received: October 24, 2011
Last updated: January 19, 2014
Last verified: January 2014
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Detailed Description:
This study is designed to compare the standard of care against EXPAREL (bupivacaine liposome extended-release injectable suspension) to determine if total opioid consumption is reduced when using EXPAREL, therefore possibly reducing total hospitalization costs.
|Bowel Obstruction
|Drug: IV morphine sulfate Drug: EXPAREL (bupivacaine liposome injectable suspension)
|Phase 4
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
|Official Title:
|A Pain Relief Trial Utilizing the Infiltration of a Multivesicular Liposome Formulation Of Bupivacaine, EXPAREL®: A Phase 4 Health Economic Trial in Adult Patients Undergoing Open Colectomy
Resource links provided by NLM:
U.S. FDA Resources
Further study details as provided by Pacira Pharmaceuticals, Inc:
Primary Outcome Measures:
- Total Opioid Burden [ Time Frame: Wound closure to time hospital discharge order written or Day 30, whichever is sooner ]Total opioid consumed (IV and PO) postsurgically until the hospital discharge order is written or through Day 30, whichever is sooner.
- Health Economic Benefits [ Time Frame: Wound closure to Day 30 ]
- Total cost of hospitalization until the time hospital discharge order is written or through Day 30, whichever is sooner.
- Length of stay (LOS), recorded in hours, defined as the time of completion of the wound closure until the hospital discharge order is written or through Day 30, whichever is sooner.
Secondary Outcome Measures:
- Incidence of Opioid-related Adverse Events and Patient Satisfaction With Postsurgical Analgesia. [ Time Frame: Wound closure to time hospital discharge order written or Day 30, whichever is sooner. ]
- Incidence of opioid-related adverse events defined as somnolence, respiratory depression, hypoventilation, hypoxia, dry mouth, nausea, vomiting, constipation, sedation, confusion, pruritus, urinary retention, and postoperative ileus.
- Responses to one question pertaining to patient satisfaction with postsurgical analgesia and four questions pertaining to postsurgical recovery following hospital discharge.
|Study Start Date:
|May 2012
|Study Completion Date:
|July 2012
|Primary Completion Date:
|July 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: IV morphine sulfate
morphine sulfate (or Sponsor-approved equivalent)
Drug: IV morphine sulfate
Patients in this group will receive IV morphine sulfate via patient-controlled analgesia (PCA) pump, as needed. The PCA pump will be set up postsurgically as soon as possible and prior to the patient leaving the post-anesthesia care unit (PACU) or immediately upon transfer to the floor if the stay in the PACU is less than 1 hour.
Other Name: morphine sulfate (or Sponsor-approved equivalent)
Experimental: EXPAREL
EXPAREL (bupivacaine liposome injectable suspension)
Drug: EXPAREL (bupivacaine liposome injectable suspension)
Patients in this group will receive 266 mg EXPAREL diluted with preservative free 0.9% normal saline to a total volume of 30 cc and administered via wound infiltration prior to wound closure. When not contraindicated, 30 mg IV ketorolac, a non-steroidal anti-inflammatory drug (NSAID), may be substituted per the site's standard of care.
All patients will be offered rescue analgesia, as needed.
Other Name: bupivacaine free base
Detailed Description:
This is a phase 4, prospective, sequential, open-label study designed to evaluate the efficacy, safety, and health economic benefits of intraoperative local wound infiltration with EXPAREL (bupivacaine liposome extended-release injectable suspension), compared with postsurgical administration of standardized intravenous (IV) morphine sulfate, for postsurgical analgesia in adult patients undergoing open colectomy with general anesthesia.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female, 18 years of age or older.
- Patients scheduled to undergo open segmental colectomy with planned primary anastamosis, as defined by cecectomy, right hemicolectomy, resection of transverse colon, left hemicolectomy, or sigmoidectomy.
- Ability to provide informed consent, adhere to study visit schedule, and complete all assessments.
Exclusion Criteria:
- Patients with a history of hypersensitivity or idiosyncratic reactions or intolerance to any local anesthetic, opioid, or propofol.
- Patients who abuse alcohol or other drug substance.
- Patients with severe hepatic impairment.
- Patients currently pregnant or who may become pregnant during the course of the study.
- Patients with any psychiatric, psychological, or other condition that the Investigator feels may make the patient an inappropriate candidate for this clinical study.
- Patients who have participated in a EXPAREL study within the last 30 days.
- Patients who have received an investigational drug within 30 days prior to study drug administration, or planned administration of another investigational product or procedure during the patient's participation in this study.
- Patients who undergo any concurrent surgical procedure during the ileostomy reversal surgery.
In addition, the patient will be ineligible if he/she meets the following criteria during surgery:
- Patients with unplanned multiple segmental resections or large intestine.
- Patients who have unplanned, temporary or permanent colostomies, ileostomies, or the like placed.
- Patients who receive intraoperative administration of opioids (other than fentanyl or analogs) or an other analgesic, local anesthetics, or anti-inflammatory agents.
- Patients who receive Entereg(R).
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01507233
Please refer to this study by its ClinicalTrials.gov identifier: NCT01507233
|United States, Florida
|University of Miami, Dept of Anesthesiology
|Miami, Florida, United States, 33136
Sponsors and Collaborators
Pacira Pharmaceuticals, Inc
|Principal Investigator:
|Keith Candiotti, M.D.
|University of Miami
More Information
Keywords provided by Pacira Pharmaceuticals, Inc:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Pacira Pharmaceuticals, Inc
|ClinicalTrials.gov Identifier:
|NCT01507233 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 24, 2011
|Results First Received:
|November 30, 2013
|Last Updated:
|January 19, 2014
Keywords provided by Pacira Pharmaceuticals, Inc:
open colectomy
Additional relevant MeSH terms:
Intestinal Obstruction
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Analgesics, Opioid
ClinicalTrials.gov processed this record on September 21, 2017


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George didn't make v1.0 of the re-draft and Thorpe had us snagging Xavier Henry.http://insider.espn.go.com/nba/insid...Rookies-110309
No. 7 pick: The Pistons select Paul George
No. 7 pick in December's redraft: Ed Davis
No. 7 pick in actual 2010 NBA draft: Greg Monroe
Monroe is no longer available here, but George looks like a real player and could have worked his way into being Tayshaun Prince's replacement. Evan Turner is also a consideration here, but I think George's upside is the key factor.
George should be a strong defensive presence in this league and also has the potential to be a top-two scorer on the team. He's a big upgrade in the "athlete" department as well, a sore point for the current Pistons roster.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Anxiety and Stress Disorders
Personally Reducing Medication
This is the second time that I am posting my question I have not found out the answer of previous question. My friend is suffering from depression and she has been on medication for 5 years. This is not biploar disorder but clinical depression. Instead of continuously using antidepressants (like Citalopram and Escitalopram) she rides out the bout of depression. Then the doctor either increases the dose of her medicine or he tells her to change her salt intake. Now she has decided that she will stop (by reducing the dose or tapering off slowly)taking the medicine no matter what. As she is so desperate. She used to say that she doesn`t want to take the medicine anymore. Has she developed the addiction to antidepressants? Will she have to take the antidepressants throughout her life? Do all depression patients take antidepressants through out their life? Is her decision is right as she also gained weight(while using escitolopram)?
Antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs) like celexa, lexapro, zoloft and prozac, as well as the other classes of antidepressants are NOT addictive. While there can be some brief withdrawal symptoms when they are suddenly stopped, when they are tapered off slowly this rarely occurs.
However, the term clinical depression encompasses a wide range of illness. Some people have one brief (and by brief, I mean 6 to 18 months) episode of depression, that with medication, counseling or both, resolves and does not return. Other people suffer a more prolonged or chronic course. Some people have many episodes of depression in their lives, with periods of months to years in between when they are fine. Other people have chronic depression that needs ongoing medication or counseling for years, if not indefinitely.
If you friend has not included counseling or therapy in her depression treatment, I would highly recommend it. It is also important that the diagnosis be correct. Many people with chronic depression may have more that one diagnosis -- a common situation is when drug and/or alcohol addiction occurs with the depression. If both problems are not treated, it is difficult for patients to improve. Clinical depression can occasionally be misdiagnosed -- it may be that the real problem is bipolar depression, or even a psychosis like schizophenia. These illnesses need different treatments.
Your friend may wish to consider getting a second opinion as to her problem. Good luck.
Nancy Elder, MD
Associate Professor
College of Medicine
University of Cincinnati


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Australian shares close at a 10-day high, helped by data showing China's manufacturing at a 13-month high as well as the declaration of a ceasefire on the Gaza strip.
5.37pm: That's all from us here at blog central, thanks for joining us on the ride, we'll be back tomorrow from 9.30am, we hope to see you then.
Click here for a full wrap of today's session.
5.25pm: David Jones chair Robert Savage will retire from the board at the end of this year, he announced late on Thursday afternoon, a day before the company's general meeting.
He will retire as chair and as a non-executive director effective December 31. He has been chair for nine years and a non-executive director for 13 years.
Peter Mason will become chair in the new year.
5.10pm: The market eased slightly from intraday levels that were about 1.3 per cent higher, which showed there were still enough negative economic issues to stop traders pushing prices further, says CMC Markets sales trader Ben Taylor:
- We did have quite a lot of optimism to start the day but there are still some pretty big issues we need to get through.
- The US fiscal cliff obviously is a consideration and the euro zone and IMF meetings going on need to be taken into account. I think the market is wary.
- Bond market yields ae heading up, suggesting financial market participants are pessimistic about the economy.
4.55pm: The Australian dollar received a lift against its US counterpart from encouraging Chinese manufacturing data, and scaled eight-month peaks against the yen on expectations of more policy action in Japan.
The Aussie rose to $US1.0390, from $US1.0363 in early trade and powered up to 85.78 yen, its strongest since early April, to last fetch 85.69.
The move higher was underpinned by an upbeat reading of China's manufacturing activity with HSBC's China flash Manufacturing PMI for November rising to a 13-month peak. The figure was seen as a further sign of economic recovery in the world's second-largest economy.
That, combined with renewed hopes of a Greek loan deal, helped sentiment and sent shares rallying across Asia.
4.33pm: Ausdrill has flagged poor December half earnings on the back of the downturn in the iron ore sector, coupled with flooding in Burkina Faso, which has interrupted drilling activities.
Earlier, it had said full year revenue would grow 15 per cent, although now it is estimating a 20 per cent rise even with the purchase of Best Tractor Parts.
There will also be $15 million of one-off costs which will hit earnings in the year. As a result, the shares were pushed to fresh two-year lows in late trading before closing flat at $2.45.
4.20pm: All the major sectors posted gains, Telecommunications added 1.8 per cent, consumer staples jumped 1.1 per cent and both materials and financials rose 0.9 per cent.
4.12pm: The market has closed stronger higher, the benchmark S&P/ASX200 jumped 43.6 points, or 1 per cent, to 4413.1, while the broader All Ords added 41.7 points, or 0.9 per cent, to 4432.4.
3.52pm: Former foreign minister Alexander Downer has joined Gina Rinehart's Roy Hill Holdings as an alternate director.
Documents lodged with ASIC show that Mr Downer was appointed on November 15 as an alternate director for one of Ms Rinehart's top lieutenants, Tad Watroba.
3.46pm: Telstra is continuing its stellar run of late, hitting new four year highs.
3.29pm: BusinessDay's Michael Pascoe says China's manufacturing is powering on despite the bad press:
Amid all the doomsday headlines generated by the China bears, Chinese industrial production has not faltered. As previously reported here, financial media and commentators have not understood the base effect of China's industrial production growth rate starting from such a high level and just continue to misreport it.
Fortunately, the markets' outlook has moved beyond the misunderstanding, now tending to focus on the broader story that China's economic growth bottomed at "only" 7.4 per cent in the September year. The HSBC flash PMI today printing at 50.4 adds to that story and the misreporting matters less.
In the footnotes to his speech to the Committee for the Economic Development of Australia on Tuesday night, RBA governor Glenn Stevens used his own example of how the greater size of China has made the concern about lower (but still amazingly high) growth rates a little silly.
Stevens put it this way: "In 2003, China's growth in real GDP of 10 per cent added 0.8 of a percentage point to global GDP. If China's growth in 2013 is 7 per cent, that will add a full percentage point to global GDP."
Click here for the full story.
3.13pm: Finance Minister Penny Wong insists the federal government is sticking to its budget surplus strategy despite figures suggesting it's falling short of the target.
Monthly financial statements for July and August released last Friday showed a budget deficit of $7.4 billion, compared an earlier expectation it would $7 billion by end August.
Senator Wong said on Thursday the monthly budget outcomes so far were consistent with the mid-year budget review released in October.
2.54pm: Silicon Valley remains the world's most attractive spot for technology start-ups with other locations around the world catching up, according to a recent report.
Silicon Valley-based start-ups raise, on average, a third more capital than those in other areas, the report, conducted by research firm start-up Genome and funded by Spanish group Telefonica, said.
Click here for the full story.
2.45pm: With the last hour of local trade fast approaching, here's what markets around the region are doing:
- Nikkei(Japan): +1.1%
- Shanghai: -0.5%
- Taiwan: +0.3%
- South Korea: +1%
- Singapore: +0.7%
- New Zealand: +0.6%
2.26pm: Bluescope Steel shares are sharply higher, enjoying strong buying on the back of an investor day on Wednesday focussing on its steel building unit, which prompted some analysts to slap a ''buy'' on the stock this morning.
Bluescope bought Butler in 2004, giving it a strong position in the prefabricated steel buildings market, which typically supplies production plants for global corporations.
In a note to clients this morning, Deutsche Bank said there is ''significant upside potential'' from the division, given the company outlined to analysts plans to double annual revenue to $3 billion by fiscal 2015, with a 5.5 per cent pretax profit margin.
Bluescope is the biggest winner on the ASX200 today, with shares up 10 per cent to 49½ cents.
By contrast fellow steelmaker Arrium is among the biggest losers on the ASX200, having dropped 1.4 per cent to 71 cents.
2.14pm: Coal traders in China have defaulted on at least three Australian thermal coal shipments in recent weeks, trade sources say, pressured by a dip in regional prices and high stocks in the world's top coal importer.
While analysts and traders said it was unlikely to signal the start of a wave of cancellations in deals, the defaults could put pressure on prices after signs of a revival earlier this month.
Australia's Newcastle spot thermal coal index has fallen as much as 30 per cent since the start of 2012 to a year-low of $81 a tonne, although prices have rebounded this week to about $84 largely in line with firmer oil prices.
"Prices might come off slightly but I don't think the defaults are going to prompt a sharp fall in domestic and regional prices like what happened in June," said a coal analyst, who asked not be named due to company policy on talking to the media.
1.52pm: BusinessDay's Colin Kruger has this to say about the unsuccessful push by some Woolworths investors to have the retailer place restrictions on the 12,000 pokie machines it controls:
The defeat was never in doubt ... but victory was probably never the intent of the investors. What they did achieve was to put Woolworth's board under its most intense examination to date to justify why Australia's largest supermarket operator needs to also be our largest owner and operator of poker machines. Whatever the board says in public, it is a damaging association for the company and a major distraction from its core business, according to one investor.
Read more here:
1.22pm: Shares in Australia's Lynas Corp soared 10 per cent after the Australian rare earths producer said it expected production to start at its long-delayed Malaysia processing plant within days.
Lynas said about 100 containers of rare earths concentrate had arrived at the Lynas Advanced Materials Plant in Kuantan and it planned to begin operations "over the coming days".
The plant has been mired in controversy, with repeated judicial challenges by locals and environmentalists worried about potential health risks.
Lynas shares rallied 10.3 per cent to 69.5 cents, but are still well below levels above $1.50 at the start of the year.
1.16pm: The Australian and New Zealand dollars scaled eight-month peaks against the yen on expectations of more policy action in Japan, while encouraging Chinese manufacturing data saw the Aussie reach a session high, as mentioned in that last post, of $US1.0401.
1.11pm: The Aussie dollar cheered the China PMI numbers. It was trading at $US1.038 just before the data was released and climbed to $US1.0401 just after.
12.59pm: More on the Chinese PMI data, which indicates that growth in the manufacturing sector is accelerating for the first time in 13 months.
''November's flash reading of HSBC manufacturing PMI bounced back to expansionary territory for the first time in 13 months, confirming that the economic recovery continues to gain momentum towards the year end," Qu Hongbin, chief China economist at index sponsor HSBC, said.
"However, it is still the early stage of recovery and global economic growth remains fragile. This calls for a continuation of policy easing to strengthen the recovery."
12.55pm: CommSec market analyst Juliana Roadley had been looking for good news from the Chinese data.
"At the moment, everything is looking rosie'' she'd dsaid, before the data was released.
''The banks are following the gains out of the US and the energy sector is getting a lift from the oil price. Even with the ceasefire, the oil price is still moving higher ... $US87.70 a barrel is a pretty good level compared to what it was a few days ago.''
12.50pm: BREAKING NEWS The Chinese PMI data is out and it's gone up to 50.4 from 49.5 after failing to hit 50 all year. The dollar has spiked on the news, rising to $US1.0398. It had hovered around the $US1.0380 mark for most of the morning.
12.43pm: Miguel Audencial, a sales trader at CMC Markets say the local market is doing well today - the SX200 index is up more than 50 points - thanks to good news on the Hamas/Israel conflict and hopes of deals on Greece and the US fiscal cliff.
Investors are also anticipating some good news from China later on, Mr Audencial said:
The all-important HSBC Flash Manufacturing PMI for China will be released later this afternoon. The index has failed to reach 50 so far this year. A figure in expansion territory has the potential to stretch the gains in the Australian equities market further today.
12.24pm: As well as the extraordinary general meeting on its pokies involvement, Woolworths has been holding its annual general meeting, where chief executive Grant O'Brien has told shareholders that the company is maintaining its expectations of a rise in annual net profit of 3 per cent to 6 per cent.
''I have been pleased with the start of the 2013 financial year and our guidance remains unchanged despite the instability of consumer confidence and some uncertainty in global financial markets,'' he told the company's annual general meeting in Adelaide.
Woolworths shares have performed well today, putting on 27 cents - 0.9 per cent - to $28.75.
12.15pm: Now for more from Myer boss Bernie Brookes who's been speaking at a business event in Sydney and has been talking up the benefits of a pre-Christmas interest rate cut.
He said Myer was expecting a flat to slightly positive Christmas, and an interest rate cut would give the department store ''a bit of a kick'' heading into the traditionally busy trading period. Mr Brookessaid he would "love to see a December rate cut":
We think the environment warrants a December rate cut and so we will keep our fingers crossed that the Reserve Bank decides to cut interest rates when the December announcement is made. If we can get a couple of interest rate decreases to try and kick start some of the economy and compensate for mining coming back, to me it is going to help retail trade in general and certainly going to help Myer.
Myer shares are up, along with the rest of the market today, rising 5 cents - 2.54 per cent - to $2.15.
12.02pm: Things can't be too bad over here if new workforce data from across the Tasman is to be believed.
According to Statistics NZ's International Travel and Migration Survey, released today, more than 10,000 manufacturing workers and more than 13,000 builders left New Zealand during the past three years.
New Zealand's Greens say most of them came here. Co-leader Russel Norman says: "If companies do look to hire, they are finding many of the skilled workers have left for Australia.''
11.50am: More on the breads and spreads supplier Goodman Fielder, which is holding its AGM in Sydney.
Managing director Chris Delaney said the company's business improvement program, Project Renaissance, was producing its targeted cost savings and operational efficiencies.
''We are right on time in delivering that $100 million, and we continue to be confident in our ability to deliver the full $100 million over the strategic plan,'' Mr Delaney told shareholders.
Shares in Goodman Fielder are up 2.6 per cent, at 59½ cents.
11.47am: The stock market might be up, but the dollar is lower after two days of decline. Reports are due out later that may show the global economy is struggling to recover, which is sapping demand for assets linked to growth.
The dollar has maintained a drop from yesterday against most of its major peers before the purchasing managers index that economists say will indicate the euro area's services and manufacturing industries shrank for a 10th month.
US figures next week are forecast to reveal a drop in demand for durable goods.
"We haven't really seen any stabilisation as far as the euro-zone economies go," said Mike Jones, a currency strategist at Bank of New Zealand.
"The PMI data will feed through to risk appetite and investor confidence, which is important for high-beta currencies" such as the dollar, he said.
In recent trade The dollar was at $1.0378 after dropping 0.4 per cent in the previous two days to $1.0369.
11.37am: An hour and a half into the day and the markets are still advancing, with the the All Ordinaries index is 45.2 points higher, or 1.0 per cent, to 4435.9, while the benchmark S&P/ASX200 is 48.1 points higher, or 1.1 per cent, to 4417.6.
Rochford Capital director Derek Mumford said Australian shares were being driven up by some positive news overseas.
"We are seeing a follow-through from the US equities markets, which were up last night on very low volume. There's also some positive sentiment as far as the Greek settlement goes," he said.
Mr Mumford said the market was also awaiting data from China on its manufacturing sector.
"Obviously there are a lot of things going on in Australia, but the bigger issues seem to be outside our borders in the US, China, Japan and Europe."
11.25am: It's hard to imagine too many sombreros being tossed skywards, but tequila makers are reportedly celebrating the news that Australia will ban imports of the drink that don't originate in Mexico.
The Tequila Regulatory Council of Mexico said that Australia joined Russia and Thailand in giving Mexico the protected designation of origin for the drink. Council director Ramon Gonzalez said the decision means that Australia will remove at least 10 "pseudo-tequilas" from the market in January.
"It is a big step to allow the industry to have a market totally free and clean of unfair competition in Australia," he said.
The council says 18 Mexican companies exported almost 825,000 litres of tequila to Australia last year.
11.20am: It's not a good time to be in the printing game, with more bad news coming today from the printing and publishing business PMP, which has annouunced it will close its Sydney plant that produces the White and Yellow Pages phone directories.
PMP today said its Chullora print plant in Sydney's west would close next June, because of falling demand for printed phone books.T
he majority of Chullora employees would likely be made redundant, the company said.
''The change in print volumes reflect changing consumer needs, which is an inevitable step in response to the realities of the digital marketplace,'' PMP chief executive Peter George said in a statement.
The redundancies are likely to cost the company about $11.5 million between June and October 2013.
PMP shares have leapt on the news - rising 5.6 per cent - 1 cent - to 19 cents.
11.14am: Stocks are also soaring in Tokyo, with the broad Topix index jumping 1.2 per cent. For the week, the gauge is set for gain a 5.3 per cent.
11.09am: The ASX200 is extending its early gains and is now up 1.1 per cent. All sectors are firing, with materials up 1.2 per cent, energy rising 1.5 per cent and financials gaining 0.9 per cent.
11.02am: Shares in Goodman Fielder are soaring after the food and ingredients company said it would review its dividend policy at the half year and was aiming to cut its cost base by $100 million by 2015.
Goodman shares rose to a high of 62.5 cents, up nearly 8 per cent, and last traded up 6.9 per cent.
10.48am: The retailers are higher with the general market:
- Myer: +1.43%
- Westfield: +0.43%
- DJs: +0.83%
- Harvey Norman: +0.55%
- Wesfarmers: +1.31%
10.40am: Here's the full story on the Woolies AGM.
10.36am: IG Markets strategist Stan Shamu said the Australian market had been nudging the 4400 mark for most of the week, after heavy falls in early November.
''That is now the key level to look out for in the near term, should the market manage to hold on to its early gains,'' he said. With no local economic data scheduled for release on Thursday, many investors would be watching manufacturing data out of China later in the day for some direction.
''Of course, if we get a strong reading, this would help support the notion that China has stabilised and lift risk assets in Asian trade,'' Mr Shamu said.
10.33am: Stocks are heading towards and 1 per cent gain in early trade. Both the All Ords and the ASX200 are 0.9 per cent higher and heading north. The ASX200 is now back above 4400, the first time since 13 November.
10.30am: Myer chief executive Bernie Brookes says the Click Frenzy online sales promotion was a big success.
Myer doubled its online sales during the Click Frenzy promotion, despite the website crashing due to a flood of users trying to log on, Mr Brookes said on Thursday.
''Sure the website crashed. It crashed on the night, but it worked bloody well yesterday (Wednesday) and it gave us some tremendous sales,'' Mr Brookes told an Australian Retailers Association breakfast in Sydney.
10.27am: The list of worst-performed companies on the ASX200 is a mixed bag:
- Ten: -1.67%
- Navitas: -1.57%
- Macquarie Atlas: -1.57%
- St Barbara: -1.17%
- Virgin: -1.09%
- Pacific Brands: -0.84%
10.25am: Billabong is leading the ASX200 higher in early trade - up 5.99 per cent. Here are the other early gainers:
- Boart Longyear: +5.46%
- Intrepid: +5%
- BlueScope: +4.89%
- Linc Energy: +4.58%
- Medusa Mining: +3.85%
- Goodman Fielder: +3.45%
10.18am: Looking now at how the sectors on the Asx200 are performing, all are higher:
- Energy: +1.30%
- Materials: +0.99%
- Industrials: +0.98%
- Consumer staples: +0.94%
- Info tech: +0.85%
- Telecoms: +0.7%
10.12am: The Australian share market has opened more than half a per cent higher. The benchmark S&P/ASX200 index was up 28.9 points, or 0.7 per cent, at 4398.4, while the broader All Ordinaries index was up 27.1 points, or 0.62 per cent, at 4417.8.
On the ASX 24, the December share price index futures contract was up 31 points at 4412, with 5310 contracts traded.
10.07am: Early take - local stocks 0.3 per cent higher as markets open.
10.02am: As well as Woolworths, other well-known companies holding AGMs today include Woolworths, Orica, AWE, Paladin, Goodman Fielder and Sonic Healthcare.
9.55am: News Corp Chairman and Chief Executive Officer Rupert Murdoch sold all of his nonvoting Class A shares in the company, retaining his voting stake.
Murdoch sold 418,631 shares on Nov. 20 for $US23.87 to $US24.01 each for a total of more than $US10 million, according to a filing to the Securities and Exchange Commission.
The sale was for estate-planning purposes, according to a person with direct knowledge of the situation who asked not to be named because the matter is sensitive.
Murdoch still holds the company's largest voting stake, with 40 per cent of Class B shares. That control makes it difficult to enact board changes that differ from his wishes. Prince Alwaleed bin Talal, a friend of the Murdoch family, owns an additional 7 per cent of voting shares.
9.51am: There is no local economic data of note out today, but at 12.45pm we get the HSBC flash manufacturing PMI for November. Wall Street is closed overnight tonight for the Thanksgiving holiday.
9.47am: Some analyst rating changes for this morning:
- Ramsay Healthcare raised to overweight at Morgan Stanley
- Cardno Ltd rated new hold at Deutsche Bank
- Programmed Maintenance cut to hold at Moelis & Company
- Insurance Australia Group cut to underperform at BofA-Merrill Lynch
- Virgin cut to underweight at Morgan Stanley
- Adelaide Brighton raised to overweight from neutral at JPMorgan
9.44am: Oil and gas company Santos expects its production to rise in 2013 as new projects come online. In a presentation to investors, the company repeated its forecast for production in calendar 2012 to be within a range of 51 million barrels of oil equivalent (mmboe) to 55 mmboe.
Chief financial officer Andrew Seaton said production in 2013 was expected to rise to a range of 53 mmboe to 57 mmboe. Production would be influenced by continued strong production from Santos' base business and the start-up of the Fletcher Finucane project off the coast of Western Australia in the second half of 2013, he said.
9.40am: More on the Woolworths pokies vote. Just 2.5 per cent of votes were in favour, with the remainder cast as open votes.The resolution sought to impose one dollar betting limits and revenue limits of $120 an hour per machine.
It would also have limited Woolworths to operating gaming machines for a maximum of 18 hours a day. The Woolworths board had urged shareholders to vote against the resolution.
''The debate today is around a motion that will apply only to Woolworths in isolation, without delivering a broader social benefit to the community who would continue to have access to unrestricted machines,'' chairman James Strong told the meeting before the vote.
9.38am: In breaking news, a majority of Woolworths shareholders have opposed a move to restrict the operation of poker machines by the supermarket giant.
More than 200 Woolworths shareholders, led by social activist group GetUp!, were seeking to impose limits on the more than 200,000 gaming machines operated by the retailer through its hotel business.
At an extraordinary general meeting in Adelaide on Thursday, more than 95 per cent of shareholders voted against GetUp!'s resolution.
9.36am: For a comprehensive look at this morning's business news, check today's need2know. Here are this morning's key market links:
- SPI futures are 25 points higher at 4406
- The $A is higher at $US1.0363
- In late trade in the US, the S&P500 was up 0.16% to 1389.99
- In Europe, the FTSE100 rose 0.07% to 5952.03
- China iron ore was flat at $US120.60 a metric tonne
- Gold fell $US1.70 to $US1728.20 an ounce
- WTI crude oil rose 42 cents to $US86.78 a barrel
- Reuters/Jefferies CRB index was flat at 296.51
9.34am: Good morning folks. Welcome to the Markets Live blog for Thursday.
This blog is not intended as investment advice
BusinessDay with agencies


text:
Thoughts about Breech Birth
by Jan Tritten
© 2013 Midwifery Today, Inc. All rights reserved.
[Editor's note: This article first appeared in Midwifery Today, Issue 106, Summer 2013.]
Midwifery Today is concerned with the need for midwives to reclaim breech, twin and VBAC births. It is important that midwives gain the skills, experience and knowledge necessary to safely assist these births. Most doctors have lost knowledge of vaginal breech birth by allowing their few skills to get rusty as they needlessly perform cesareans for breech babies. Some doctors are willing to go against the "standard of care" (or shall we call it "the standard lack of care"), but they are few and far between. Even when vaginal breech births were the norm instead of the exception, docs mainly used a medicalized approach to breech while neglecting some of the basic techniques, such as using physiology, position of the mother, and remaining hands-off and knowing when to be hands-on.
There are "better ways" when handling breech babies, but I do not have those skills or experience, so I am not qualified to attend breech birth. Breech births are not for beginners, so be sure to be mentored in breech and study it intensely before you provide care at a breech birth. (However, every midwife needs to know as much as possible for the occasional surprise breech.) As in vertex babies, many breeches can be butter births and just slide right out if you do not disturb the mother and thus protect the natural oxytocin flow. Complications are rare, but you must be ready for them as with any birth you take on. Having a complete understanding of normal and how to let it be and not disturb is as important as knowing what to do when something is needed—this is the art of midwifery.
Hands-on care is another skill Midwifery Today is concerned with teaching, and we do this in the magazine and at our conferences. We have begun substituting medicine (drugs and invasive procedures) with more effective and less invasive ways to help motherbaby. Let's not lose or fail to teach those hands-on, heart-on skills. Many doctors have not palpated babies in decades. Getting to know the mother and the baby is key to good care.
I have been to three very interesting hospital breech births that were greatly affected by the care provider.
Dr. A helped us with a breech birth, but his nervousness made his help dangerous. He unnecessarily applied forceps and caused a bloody and horrible mess. He was so scared he couldn't even ascertain that the baby was coming out fine on its own. He was visibly shaking and rushed with the forceps because the baby was coming so quickly.
Dr. B helped with a breech birth, and though he was very serious and performed an unnecessary episiotomy, it was a lovely birth otherwise.
Dr. C helped my partner and me with such enthusiasm that the mother and I still talk about her breech birth with joy as we recall the helpful doctor and his skill at that birth nearly 30 years ago. It was wonderful and how 90% or more of breech babies would come out if allowed to.
How do you as a midwife get ready for being able to do breech births? At Midwifery Today conferences we dedicate a full day and then some breakout classes and roundtables to breech birth. At conferences, you can bring your questions to our helpful and skilled teachers. You need to study everything you can on breech. Try to get as much experience as you can with as many different practitioners. Find a mentor—MT conferences are a good place to find one. Attend the yearly Heads Up! Breech Conference and continue to read this magazine!
My friend and colleague Cornelia Enning has done breeches only in water for the past 30+ years. She teaches us that breech is far safer in water. She has written about it in this issue. After spending time with her and taking her classes at our conferences, I agree. The main point is you have more time for everything, whether that is a prolapsed cord or a slower-descending baby. There is less pressure on the baby and the cord because of the water. The following anonymous story shows how water can be the perfect medium for providing safety in an otherwise unsafe situation (cord prolapse).
A gravida 2 para 1 in her mid-twenties, who had already successfully birthed her first baby in a cephalic presentation, came to the birth of her second child with the baby presenting breech. Fetal lie had been diagnosed by ultrasound, and the possibility of a footling descent was noted. When her water broke spontaneously, she entered the birth tub. Immediately after the breaking of her water and throughout the labour, the fetal heart tones were extremely reassuring.
Eventually the mother began pushing. A presenting part appeared at the introitus; upon assessment it was discovered to be the baby's umbilical cord pulsing visibly in the 130s and 140s. It remained stable for over thirty minutes. A sudden drop in fetal heart tones necessitated immediate delivery. After three minutes of continuous pushing, the baby was born. He was somewhat shocked at first, but his Apgar's were good.
Most midwives won't do footling breeches, but the midwife in the above story was very experienced in breech birth. If, as a midwife, you have experience with breech in water, please tell me your thoughts at email@example.com.
Toward better birth,
Jan Tritten
Jan Tritten is the founder and editor-in-chief of Midwifery Today magazine and a midwife who was in active practice from 1977 to 1989. She became a midwife in 1977 after the powerful homebirth of one of her daughters. Her mission is to make loving midwifery care the norm for birthing women and their babies throughout the world. Meet Jan at our conferences around the world! [ PHOTO BY ANDREA NOLL ]
Jan on Twitter: https://twitter.com/jantritten
Midwifery Today on Facebook: facebook.com/midwiferytoday
Jan on Facebook: facebook.com/JanTrittensBirthPage
International Alliance of Midwives on Facebook: facebook.com/IAMbirth
Birth Is a Human Rights Issue: facebook.com/birthisahumanrightsissue
Midwifery Education: Caring and Sharing: facebook.com/MidwiferyEducation
View upcoming Midwifery Today editorial themes.
Don't miss out on the great editorials in Midwifery Today. Subscribe today!


text:
New for 2014
The Buick Regal gets a refresh for the 2014 model year, with newly available all-wheel drive, and revisions to the turbocharged 2.0-liter I-4 that give non-GS models more power and make it more fuel efficient. New technology highlights include an eight-inch touchscreen IntelliLink infotainment system, and a host of new optional safety features such as full-speed-range adaptive cruise control.
Vehicle Overview
The Buick Regal is the automaker's midsize sedan that fits below the upscale LaCrosse and above the smaller Verano. It strives to balance sport and luxury, and even has a manual-transmission option.
The 2014 Buick Regal comes with a turbocharged I-4 or an engine-stop-start-equipped eAssist I-4. The standard and more popular engine is the 259-hp turbocharged 2.0-liter I-4 that makes 295 lb-ft of torque, which can be coupled to a six-speed automatic in front- or all-wheel drive form, or a six-speed manual in FWD guise. The numerous combinations net an EPA-estimated range of 19-21/27-31 mpg city/highway, with the typical penalty for AWD over FWD. The eAssist engine is a 182-hp 2.4-liter I-4 that makes 172 lb-ft of torque, assisted by an electric motor that helps improve efficiency by allowing the engine to shut off at a stop and smoothly start again. The 2014 Regal eAssist can only be had with the six-speed automatic and FWD, which is good for an EPA-estimated 25/36 mpg.
The 2014 Buick Regal received a five-star overall safety rating from the NHTSA (out of a possible five stars), and in IIHS testing earned a rating of good in the four categories in which it has been tested (the highest-available rating is good). The Regal also features a number of radar and camera based safety features, highlights include: collision mitigation braking that can stop the car in certain crash-imminent situations and full-speed-range adaptive cruise control.
What We Think
The new AWD system has an electronic differential in the center which can send up to 90 percent of the power to the rear wheels, where the rear differential can then send the power to the wheel with the most grip. The system is on-demand, and only activates when needed. In a 2014 review of a Buick Regal GS AWD we noted that, "the 2014 Regal GS handled admirably and exhibited no noticeable torque steer. At the same time, the turbocharged 2.0-liter engine suffered from enough turbo lag for us to notice some compromise in throttle modulation, which is pretty important when you're sliding across the ice toward a snow bank." Regarding the competition we said, "If Buick really wants to make cars that rival luxury-trimmed models of the Audi A4 and BMW 3 Series, it has a ways to go."
You'll Like
- Available all-wheel drive
- Safe, sporty, and well-appointed
- Available six-speed manual
You Won't Like
- Turbo-lag
- Need more than just a lower price to entice people to switch to the Buick
- eAssist model doesn't match with sporting image
Key Competitors
- Audi A4
- Acura TSX
- Volvo S60
- Lexus IS 250
- Infiniti Q50


text:
Pharmacokinetic and in Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency
This study has been completed.
University of Oxford
Information provided by (Responsible Party):
University of Oxford
ClinicalTrials.gov Identifier:
First received: August 1, 2012
Last updated: November 2, 2015
Last verified: November 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The emergence of partial artemisinin resistance in Plasmodium falciparum on the Cambodia-Thai border and more recently on the Myanmar-Thai border jeopardizes the renewed global efforts of control and elimination of malaria. Containment of this severe threat requires reduction of transmission of the resistant phenotype by adding gametocytocidal drugs to the treatment of falciparum malaria. Mathematical models also predict that transmission blocking will be required if the goal of malaria elimination is to be achieved. The only drug currently available with strong gametocytocidal properties against the more mature gametocytes is primaquine. However, the oxidative properties of primaquine readily causes acute haemolysis in glucose 6 phosphate dehydrogenase (G6PD) deficiency, the degree of which appears to be inversely related to G6PD enzyme activity. Because of these safety concerns, primaquine is not widely deployed in treatment regimens for falciparum malaria, even in areas with documented artemisinin resistance. Methylene blue, which does not exert its action through an oxidative mechanism, is a promising alternative as a gametocytocidal adjuvant to artemisinin combination therapies (ACTs). Paul Ehrlich discovered methylene blue as the first synthetic drug ever to treat malaria. In contrast with primaquine, the thiazine dye methylene blue asserts its properties as an oxidizing agent only at very high doses, whereas at pharmacologic doses it has reducing agent properties and is for this reason used as a medication for the treatment of methemoglobinemia. A recent laboratory study identified methylene blue as a potent inhibitor of gametocyte development across all stages, almost fully abolishing P. falciparum transmission to mosquitoes at concentrations readily achievable in humans. In addition, a recent clinical study in 180 children with uncomplicated falciparum malaria in Burkina Faso showed that, compared to artesunate-amodiaquine alone, addition of the cheap drug methylene blue to either artesunate or amodiaquine importantly reduced gametocyte carrier rates measured at days 3, 7, and 14 of follow-up. This effect was seen both in patients with and without P. falciparum gametocytaemia at baseline. The current series of studies will investigate further methylene blue as a potential gametocytocidal drug in the treatment of uncomplicated falciparum malaria.
|G6PD Normal G6PD Deficient Healthy
|Drug: Regimens (Primaquine, Methylene blue)
|Phase 1
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Open Label Randomized Controlled Trial Pharmacokinetic and Vitro Transmission Blocking Activities Study of Primaquine Compare to Methylene Blue in Healthy Volunteer Both G6PD Normal and G6PD Deficiency
Resource links provided by NLM:
Genetics Home Reference related topics: glucose-6-phosphate dehydrogenase deficiency
MedlinePlus related topics: G6PD Deficiency
Drug Information available for: Methylene blue Primaquine phosphate Primaquine
Genetic and Rare Diseases Information Center resources: Glucose-6-phosphate Dehydrogenase DeficiencyU.S. FDA Resources
Further study details as provided by University of Oxford:
Primary Outcome Measures:
- Pharmacokinetic profile of Primaquine [ Time Frame: 7 days ]Maximum concentration (Cmax), Area under the concentration curve (AUC 0-24), Elimination rate constant (PRQ-λz), and Elimination half life (t1/2) for primaquine when given standard dose in G6PD normal and G6PD deficiency
- Pharmacokinetic profile of Carboxyprimaquine [ Time Frame: 7 days ]Maximum concentration (Cmax), area under the concentration curve (AUC 0-24), elimination rate constant (PRQ-λz), and elimination half life (t1/2) for carboxyprimaquine (primaquine metabolite) when given standard dose in G6PD normal and G6PD deficiency
- Pharmacokinetic profile of Methylene blue [ Time Frame: 7 days ]Maximum concentration(Cmax), area under the concentration curve (AUC 0-24) elimination rate constant (MB-λz), and elimination half life (t1/2) for methylene blue when given standard dose in G6PD normal and G6PD deficiency
- Oocysts production in mosquitoes [ Time Frame: 7 days ]Reduction of oocysts production in mosquitoes fed with gametocytes which were exposed to methylene blue and primaquine
- Methaemoglobin, Hematocrit and Hemoglobin levels [ Time Frame: 7 days ]Methaemoglobin, hematocrit and hemoglobin level when given primaquine and methylene blue in G6PD normal and G6PD deficiency
Secondary Outcome Measures:
- Safety of Primaquine and Methylene Blue [ Time Frame: 1 month ]Safety and tolerability parameters, including adverse events, clinical laboratory, and vital signs assessments
|Study Start Date:
|July 2013
|Study Completion Date:
|October 2014
|Primary Completion Date:
|October 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: G6PD Normal
Subjects will be given either primaquine, 45 mg single dose or methylene blue, 600 mg single dose with a washout period of 7 days then followed by either methylene blue, 600 mg single dose or primaquine, 45 mg single dose.
Drug: Regimens (Primaquine, Methylene blue)
Primaquine 45 mg single dose Or Methylene Blue 600 mg single dose followed by Methylene Blue 600 mg single dose or Primaquine 45 mg single dose.
Experimental: G6PD deficiency
Subjects will be given either primaquine, 45 mg single dose or methylene blue, 600 mg single dose with a washout period of 7 days then followed by either methylene blue, 600 mg single dose or primaquine, 45 mg single dose.
Drug: Regimens (Primaquine, Methylene blue)
Primaquine 45 mg single dose Or Methylene Blue 600 mg single dose followed by Methylene Blue 600 mg single dose or Primaquine 45 mg single dose.
|Ages Eligible for Study:
|18 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
For G6PD normal group, healthy males and females as judged by a physician with no abnormality identified on a medical evaluation including medical history and physical examination with laboratory diagnosis of G6PD normal.
For G6PD deficient group, healthy males with laboratory diagnosis of G6PD deficiency grade 3 with enzyme activity 10-60%.
- Subjects aged between 18 years to 60 years.
- Subjects who have Hb ≥ 11 mg/dl.
A female is eligible to enter and participate in this study if she is:
- of non-childbearing potential including pre-menopausal females with documented (medical report verification) hysterectomy or double oophorectomy
- or postmenopausal defined as 12 months of spontaneous amenorrhea or 6 months of spontaneous amenorrhea with serum follicle stimulating hormone levels >40 mIU/mL or 6 weeks postsurgical bilateral oophorectomy with or without hysterectomy
- or of childbearing potential, has a negative serum pregnancy test at screening and urine pregnancy test prior to start the study drug in each period, and abstain from sexual intercourse or agrees to using effective contraceptive methods (e.g., intrauterine device, hormonal contraceptive drug, tubal ligation or female barrier method with spermicide) during the study until completion of the follow-up procedures.
- Read, comprehend, and write at a sufficient level to complete study-related materials.
- Provide a signed and dated written informed consent prior to study participation.
- Normal electrocardiogram (ECG) with QTc < 450 msec.
- Willingness and ability to comply with the study protocol for the duration of the trial.
Exclusion Criteria:
- Females who are pregnant, trying to get pregnant, or are lactating.
- A positive pre-study hepatitis B surface antigen, positive hepatitis C antibody, or positive human immunodeficiency virus-1 (HIV-1) antibody result at screening.
- Subjects with a personal history of hypertension, cardiac disease, symptomatic or asymptomatic arrhythmias, syncopal episodes, or additional risk factors for torsades de points (heart failure, hypokalemia).
- Subjects with a family history of sudden cardiac death.
- A creatinine clearance <70 mL/min as determined by Cockcroft-Gault equation: CLcr (mL/min) = (140 - age) * Wt / (72 * Scr) (multiply answer by 0.85 for females) Where age is in years, weight (wt) is in kg, and serum creatinine (Scr) is in units of mg/dL [Cockcroft, 1976].
- History of alcohol or substance abuse or dependence within 6 months of the study: History of regular alcohol consumption averaging >7 drinks/wk for women or >14 drinks/wk for men. One drink is equivalent to 12 g alcohol = 5 oz (150 mL) of wine or 12 oz (360 mL) of beer or 1.5 oz (45 mL) of 80 proof distilled spirits within 6 months of screening.
- Use of prescription or non-prescription drugs except paracetamol at doses of up to 2 grams/day, including vitamins, herbal and dietary supplements (including St. John's Wort) within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose of study medication until the completion of the follow-up procedure, unless in the opinion of investigator, the medication will not interfere with the study procedures or compromise subject safety.
- The subject has participated in a clinical trial and has received a drug or a new chemical entity within 30 days or 5 half lives, or twice the duration of the biological effect of any drug (whichever is longer) prior to the first dose of study medication.
- The subject is unwilling to abstain from ingesting alcohol within 48 hours prior to the first dose of study medication until collection of the final pharmacokinetic sample during each regimen.
- The subject is unwilling to abstain from the ingestion of grapefruit containing products for 72 hours prior to the start of dosing until collection of the final pharmacokinetic sample during each period.
- Subjects who have donated blood to the extent that participation in the study would result in more than 300 mL blood donated within a 30-day period. Note: This does not include plasma donation.
- Subjects who have a history of allergy to the study drug or drugs of this class, or a history of drug or other allergy that, in the opinion of the investigator, contraindicates participation in the trial. In addition, if heparin is used during pharmacokinetic sampling, subjects with a history of sensitivity to heparin or heparin-induced thrombocytopenia should not be enrolled.
- Those who, in the opinion of the investigator, have a risk of non-compliance with study procedures.
- AST or ALT >1.5 upper limit of normal (ULN).
- Subjects with history of renal disease, hepatic disease, and/or cholecystectomy.
- Abnormal methaemoglobin level.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01668433
Please refer to this study by its ClinicalTrials.gov identifier: NCT01668433
|Hospital for Tropical Diseases
|Bangkok, Thailand, 10400
Sponsors and Collaborators
University of Oxford
More Information
Keywords provided by University of Oxford:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
|Responsible Party:
|University of Oxford
|ClinicalTrials.gov Identifier:
|NCT01668433 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 1, 2012
|Last Updated:
|November 2, 2015
Keywords provided by University of Oxford:
Methylene blue
Additional relevant MeSH terms:
Glucosephosphate Dehydrogenase Deficiency
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn
Carbohydrate Metabolism, Inborn Errors
Metabolism, Inborn Errors
Metabolic Diseases
Methylene Blue
Antiprotozoal Agents
Antiparasitic Agents
Anti-Infective Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 25, 2017


text:
Guess the object
Keep them guessing with 20 questions. Kids will have a great time making up an object or choosing an object from their surrounds to keep their opponents puzzled all trip long! From fruit to flies, everyone can have fun with this great family game!
Number of players:
One person starts the game and thinks of something which falls under the category of animal, insect, or fruit.
That person discloses ONLY the category their chosen object falls into.
The players then take turns asking questions which can be answered with a YES or NO.
For instance, if the category is an insect a player might ask "Can it fly?" or "Is it poisonous?"
Up to 20 questions can be asked.
If the players have not guessed the answer in 20 questions, each player gets a last chance to make a guess at the object.
Afterwards, a new player starts with their chosen category.
Find more great play ideas:
- Play ideas for fun
- Games to play with babies
- Learning games
- Birthday party games
- Games to play outside
- Science experiments to do in the kitchen
Find more ideas for toddlers
- Eat, sleep and play ideas for toddlers
- Nursery rhyme lyrics
- Kids' songs and lullaby lyrics
- Games, crafts and activities for 2-year-olds
- How-to make your own toys videos
- 20 fun toddler activities and games
- Toddler play
- Best recipes for toddlers
- Solving toddler tantrums
- Craft ideas for 1-2 year olds
- Craft ideas for 2-3 year olds
- Craft ideas for 2-3 year olds


text:
I wish I would have found this Novel High Heel Lady Shoe Shaped Telephone sooner to add to my Christmas Gift Ideas for Shoe Lovers List as it is definitely affordable at only $17.59 with Free Worldwide Shipping from FocalPrice. Sure, I know land-line telephones are becoming a thing of the past, but I think this would look super cool in my office as a conversation piece even if I didn't use it to actually talk on! Plus it would match my Red Shoe Tape Dispenser! Early Valentine's Day gift idea for myself?!
One thought on "Red High Heel Shoe Telephone"
Maybe it's just me, but that looks like a relic from the 1980's.


text:
KOMONO offers a smart collection on unisex watches, perfect for the shifting trends within today's men's streetwear scene. The brand designs for a demographic it calls "Komonists." The Komonoist is someone who strives for a higher state of consciousness and style, and reaches for a getaway from the monotony of daily routines—a place where he can inject color into a grey world. The KOMONO watch collection strives to create a world of retro-futuristic jewelry and accessories that ignite the spirit and tickle the senses.
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