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Home > Health & Wellness > Health Library > Childhood Brain Stem Glioma Treatment (PDQ®): Treatment - Patient Information [NCI]
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.
Childhood brain stem glioma is a disease in which benign (noncancer) or malignant (cancer) cells form in the tissues of the brain stem.
Gliomas are tumors formed from glial cells. Glial cells in the brain hold nerve cells in place, bring food and oxygen to them, and help protect them from disease, such as infection.
The brain stem is the part of the brain connected to the spinal cord. It is in the lowest part of the brain, just above the back of the neck. The brain stem is the part of the brain that controls breathing, heart rate, and the nerves and muscles used in seeing, hearing, walking, talking, and eating. Most childhood brain stem gliomas are pontine gliomas, which form in a part of the brain stem called the pons.
Anatomy of the brain showing the cerebrum, ventricles (with cerebrospinal fluid shown in blue), cerebellum, brain stem (pons and medulla), and other parts of the brain.
Brain tumors are the third most common type of cancer in children.
This summary refers to the treatment of primary brain tumors (tumors that begin in the brain). Treatment for metastatic brain tumors, which are tumors formed by cancer cells that begin in other parts of the body and spread to the brain, is not discussed in this summary.
Brain tumors can occur in both children and adults; however, treatment for children may be different than treatment for adults. See the following PDQ treatment summaries for more information:
Brain tumors may be benign (not cancer) or malignant (cancer).
Benign brain tumors grow and press on nearby areas of the brain. They rarely spread into other tissues. Malignant brain tumors are likely to grow quickly and spread into other brain tissue. When a tumor grows into or presses on an area of the brain, it may stop that part of the brain from working the way it should. Both benign and malignant brain tumors can cause signs and symptoms and need treatment.
There are two types of brain stem gliomas in children.
Childhood brain stem glioma is either a diffuse intrinsic pontine glioma (DIPG) or a focal or low-grade glioma.
The cause of most childhood brain tumors is unknown.
Anything that increases your risk of getting a disease is called a risk factor. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer. Talk with your child's doctor if you think your child may be at risk. Possible risk factors for brain stem glioma include:
The signs and symptoms of brain stem glioma are not the same in every child.
Signs and symptoms depend on the following:
Some tumors do not cause signs or symptoms. Signs and symptoms may be caused by childhood brain stem gliomas or by other conditions. Check with your child's doctor if your child has any of the following:
Tests that examine the brain are used to detect (find) childhood brain stem glioma.
The following tests and procedures may be used:
A biopsy may be done to diagnose certain types of brain stem glioma.
If the MRI scan looks like the tumor is a DIPG, a biopsy is usually not done and the tumor is not removed.
If the MRI scan looks like a focal or low-grade brain stem glioma, a biopsy may be done. A part of the skull is removed and a needle is used to remove a sample of the brain tissue. Sometimes, the needle is guided by a computer. A pathologist views the tissue under a microscope to look for cancer cells. If cancer cells are found, the doctor will remove as much tumor as safely possible during the same surgery.
Craniotomy: An opening is made in the skull and a piece of the skull is removed to show part of the brain.
The following test may be done on the tissue that was removed:
Certain factors affect prognosis (chance of recovery) and treatment options.
The prognosis and treatment options depend on:
The plan for cancer treatment depends on whether the tumor is in one area of the brain or has spread all through the brain.
Staging is the process used to find out how much cancer there is and if cancer has spread. It is important to know the stage in order to plan treatment.
There is no standard staging system for childhood brain stem glioma. Treatment is based on the following:
These brain stem gliomas usually do not spread outside the brain stem.
A focal or low-grade brain stem glioma may recur many years after first being treated. The tumor may come back in the brain or in other parts of the central nervous system. Before cancer treatment is given, imaging tests, a biopsy, or surgery may be done to make sure there is cancer and find out how much cancer there is.
There are different types of treatment for children with brain stem glioma.
Different types of treatment are available for children with brain stem glioma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.
Because cancer in children is rare, taking part in a clinical trial should be considered. Some clinical trials are open only to patients who have not started treatment.
Children with brain stem glioma should have their treatment planned by a team of health care providers who are experts in treating childhood brain tumors.
Treatment will be overseen by a pediatric oncologist, a doctor who specializes in treating children with cancer. The pediatric oncologist works with other pediatric health care providers who are experts in treating children with brain tumors and who specialize in certain areas of medicine. These may include the following specialists:
Childhood brain stem gliomas may cause signs or symptoms that begin before the cancer is diagnosed and continue for months or years.
Childhood brain stem gliomas may cause signs or symptoms that continue for months or years. Signs or symptoms caused by the tumor may begin before diagnosis. Signs or symptoms caused by treatment may begin during or right after treatment.
Some cancer treatments cause side effects months or years after treatment has ended.
These are called late effects. Late effects may include the following:
Some late effects may be treated or controlled. It is important to talk with your child's doctors about the effects cancer treatment can have on your child. (See the PDQ summary on Late Effects of Treatment for Childhood Cancer for more information).
Six types of standard treatment are used:
Surgery may be used to diagnose and treat childhood brain stem glioma as discussed in the General Information section of this summary.
Radiation therapy
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer.
Radiation therapy to the brain can affect growth and development in young children. Conformal radiation therapy is a type of radiation therapy that uses a computer to make a 3-dimensional (3-D) picture of the tumor and shapes the radiation beams to fit the tumor. This allows a high dose of radiation to reach the tumor and causes less damage to normal tissue around the tumor.
The way the radiation therapy is given depends on the type of the cancer being treated. External radiation therapy is used to treat DIPG. External and/or internal radiation therapy may be used to treat focal or low-grade brain stem gliomas.
Several months after radiation therapy to the brain, imaging tests may show changes to the brain tissue. These changes may be caused by the radiation therapy or may mean the tumor is growing. It is important to be sure the tumor is growing before any more treatment is given.
Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly in the cerebrospinal fluid, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type of the cancer being treated.
Because radiation therapy to the brain can affect growth and brain development in young children, clinical trials are studying ways of using chemotherapy to delay or reduce the need for radiation therapy.
Cerebrospinal fluid diversion
Cerebrospinal fluid diversion is a method used to drain fluid that has built up in the brain. A shunt (long, thin tube) is placed in a ventricle (fluid-filled space) of the brain and threaded under the skin to another part of the body, usually the abdomen. The shunt carries extra fluid away from the brain so it may be absorbed elsewhere in the body.Cerebrospinal fluid (CSF) diversion. Extra CSF is removed from a ventricle in the brain through a shunt (tube) and is emptied into the abdomen. A valve controls the flow of CSF.
Observation is closely monitoring a patient's condition without giving any treatment until signs or symptoms appear or change.
Targeted therapy
Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells.
Some focal or low-grade brain stem gliomas that cannot be removed by surgery may be treated with BRAF kinase inhibitor therapy. BRAF kinase inhibitors block the BRAF protein. BRAF proteins help control cell growth and may be mutated (changed) in some types of brain stem glioma. Blocking mutated BRAF kinase proteins may help keep cancer cells from growing.
New types of treatment are being tested in clinical trials.
Information about clinical trials is available from the NCI Web site.
Patients may want to think about taking part in a clinical trial.
For some patients, taking part in a clinical trial may be the best treatment choice. Clinical trials are part of the cancer research process. Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment.
Many of today's standard treatments for cancer are based on earlier clinical trials. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment.
Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward.
Patients can enter clinical trials before, during, or after starting their cancer treatment.
Some clinical trials only include patients who have not yet received treatment. Other trials test treatments for patients whose cancer has not gotten better. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment.
Clinical trials are taking place in many parts of the country. See the Treatment Options section that follows for links to current treatment clinical trials. These have been retrieved from NCI's listing of clinical trials.
Follow-up tests may be needed.
Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Some tests will be repeated in order to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your child's condition has changed or if the cancer has recurred (come back). These tests are sometimes called follow-up tests or check-ups.
If the results of imaging tests done after treatment show a mass in the brain, a biopsy may be done to find out if it is made up of dead tumor cells or if new cancer cells are growing. In children who are expected to live a long time, regular MRIs may be done to see if the cancer has come back.
Newly Diagnosed Childhood Brain Stem Glioma
Newly diagnosed childhood brain stem glioma is a tumor for which no treatment has been given. The child may have received drugs or treatment to relieve signs or symptoms caused by the tumor.
Standard treatment of diffuse intrinsic pontine glioma (DIPG) may include the following:
Standard treatment of focal or low-grade glioma may include the following:
Treatment of brain stem glioma in children with neurofibromatosis type 1 may be observation. The tumors are slow-growing in these children and may not need specific treatment for years.
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with untreated childhood brain stem glioma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.
Recurrent Childhood Brain Stem Glioma
Treatment of recurrent diffuse intrinsic pontine glioma is usually palliative therapy, to relieve symptoms and improve the child's quality of life. The child may also be treated in a clinical trial of a new treatment.
Treatment of recurrent focal or low-grade childhood brain stem glioma may include the following:
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent childhood brain stem glioma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your child's doctor about clinical trials that may be right for your child. General information about clinical trials is available from the NCI Web site.
For more information about childhood brain tumors, see the following:
For more childhood cancer information and other general cancer resources, see the following:
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Editorial changes were made to this summary.
About PDQ
Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine. Most summaries come in two versions. The health professional versions have detailed information written in technical language. The patient versions are written in easy-to-understand, nontechnical language. Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish.
PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government's center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.
Purpose of This Summary
This PDQ cancer information summary has current information about the treatment of childhood brain stem glioma. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.
Reviewers and Updates
Editorial Boards write the PDQ cancer information summaries and keep them up to date. These Boards are made up of experts in cancer treatment and other specialties related to cancer. The summaries are reviewed regularly and changes are made when there is new information. The date on each summary ("Date Last Modified") is the date of the most recent change.
The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Pediatric Treatment Editorial Board.
Clinical Trial Information
A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another. Trials are based on past studies and what has been learned in the laboratory. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.
Clinical trials are listed in PDQ and can be found online at NCI's Web site. Many cancer doctors who take part in clinical trials are also listed in PDQ. For more information, call the Cancer Information Service 1-800-4-CANCER (1-800-422-6237).
Permission to Use This Summary
PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as "NCI's PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary]."
The best way to cite this PDQ summary is:
National Cancer Institute: PDQ® Childhood Brain Stem Glioma Treatment. Bethesda, MD: National Cancer Institute. Date last modified <MM/DD/YYYY>. Available at: http://www.cancer.gov/types/brain/patient/child-glioma-treatment-pdq. Accessed <MM/DD/YYYY>.
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The information in these summaries should not be used to make decisions about insurance reimbursement. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page.
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For more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.
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Last Revised: 2015-05-13
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In reply to Ajay Brar's post on Tue 10 Jan 2012 :
I am not sure if Kickstarter.com is open to those outside the United States yet, but I raised $11,000+ for my documentary.
Thu 12 Jan 2012
In reply to Ajay Brar's post on Tue 10 Jan 2012 :
I am not sure if Kickstarter.com is open to those outside the United States yet, but I raised $11,000+ for my documentary.
Thu 12 Jan 2012
SUBJECT: BEST STUDENT FILM, DOC SHORT, and DISABILITY FILM FESTS/COMPETITIONS
Hello Mentors,
I've just completed my first of several short film as part of Stanford University's MFA in Documentary Film program. The film is solid, about 5 min, and focuses on disability but in an unexpected way.
I had a bad (and expensive) experience applying to festivals with a short I directed as an undergrad. Can someone suggest (or direct me to some posts about) some of the better film festivals or competitions for student films and films about disability? I have a fear of blowing a lot of money applying to festivals out of my league or that don't really have much value as a networking event.
Sun 15 Jan 2012
In reply to Oggi Tomic's post on Tue 10 Jan 2012 :
Thanks Oggi. I've been trying to avoid crowdfunding but looks like that will be the way to go.
Sun 15 Jan 2012
In reply to Reid B. Kimball's post on Thu 12 Jan 2012 :
Kickstarter is only for US residents. There is a crowdfunding thing here in Oz too, I've just been avoiding it and trying for production houses and broadcasters.
Wed 18 Jan 2012
Hi all, I'm currently trying to raise funding for a documentary about a network of controversial adolescent drug abuse programs that I was a member of for five years. We just released a pitch trailer and launched an IndieGoGo campaign.
I would love to get some feedback from professionals on what we are doing right and what we could be doing better. This is my first time trying to do something like this and I could use all the help you can offer.
The trailer and IndieGoGo page are here. http://www.indiegogo.com/thegroup
Not asking for donations here, just looking for feedback. Thanks in advance.
Thu 19 Jan 2012
Hi Jacob,
This looks like a really interesting story, especially since you have the inside scoop.
I am wondering if you have any other footage besides the talking heads and pictures. Are there scenes you can shoot? Or can you come up with some creative B-Roll that relates to the feelings that everyone is talking about? I know you are just beginning with telling your story, but I think it is always good to think in these terms. Best of luck!
Thu 19 Jan 2012
Hi Jill,
Thanks for checking it out.
Right now, we have about 13 hours worth of video footage that was shot by members of The Group and more coming. We didn't use any in the trailer because we are still working out the legalities of using it, but we intend to use some of it in the film.
As for B-roll, we plan to get footage of our interview subjects in their daily lives, plus just shooting anything interesting that comes up when we are on location.
Thu 19 Jan 2012
Subject looks compelling so far. I have heard of extreme drug programs (like the right wing christian ones that periodically get shut down by a state gov and then pop up elsewhere under a different name) but this is the first I heard about one totally run by kids. Lots of parallels though in terms of the brainwashing, peer pressure and torture lite techniques. Was there money involved? Anyone profiting?
Fri 20 Jan 2012
In reply to Jill Woodward's post on Fri 20 Jan 2012 :
Hi Jill. There is definitely a profit being made. My family, for example, which is a working-class family, spent around $70,000 in the five years that I was involved. The money is from treatment programs (in-patient and out-patient). They convince parents that without the treatment their child will literally die.
We were very limited in what we could go into with the teaser trailer, but we plan to explore the whole history of the organization in the final film.
The entire operation was founded by one man who is a convicted-felony, former heroin addict and self-professed murderer. There has been a lot written about the organization going back to the 1970s. Here's a link to a little background information, if you're curious.
Thanks for checking it out. If you have any advice, I sure could use it.
Fri 20 Jan 2012
sounds very similar to Kids of Bergen County, where my friend was incarcerated, it changed names and moved around a lot to avoid regulation. From your trailer I almost thought it was the kids organizing themselves, but it sounds very much like there is an adult orchestrating and profiting. Good luck!
Fri 20 Jan 2012
In reply to Jill Woodward's post on Fri 20 Jan 2012 :
It's very similar to the Kids of Bergen County and the Straight program.
Fri 20 Jan 2012
Jacob, nice job on your first film so far, but I do see a couple areas to work on.
Sound quality is inconsistent, some sounded echo-y while others sounded high quality but too soft and quiet, I'm hard of hearing. I like to make sure the sound is loud but not too loud. People can always turn their sound down, but I had maxed the sound on my sys and headphone and still had a hard time hearing a lot of what was said.
Also, be more conscious of where your key lights are falling on the interview subject's face and which direction they are looking in. In one scene, in the bedroom, the key light was behind the person, not in front. So, we see most of their face being dark with the back side of the face lit. Other scenes the subject is to one side of the frame (rule of thirds) but is looking towards the short side, not the long side.
I've made all these mistakes myself. It's a challenge to keep all this conscious when you are trying to setup equipment and think about the interview questions, etc.
Sun 22 Jan 2012
In reply to Reid B. Kimball's post on Sat 21 Jan 2012 :
Reid, thanks for the feedback. We had a lot of difficulties with light in one of the interviews. We were using natural light and had issues with the sun moving behind clouds and also getting dark early. We tried out best to fix it with some color correction, but there was only so much we could do.
Hopefully, if we are able to raise the money, we will be able to budget for lights and have much more control over the finished product.
As for the sound, I confess I don't know much about it, but I did notice that it jumps around from interview to interview.
Thanks for all the feedback. I really appreciate it.
Thu 26 Jan 2012
I'm purchasing E&O for my first doc deal. I have no idea of what this should cost. I have a quote for a 10K deduct on a 1M/3M policy for 3 years for $5500. Is this in the range of what you guys have paid?
This doc is pretty safe – no digging up dirt, no famous people, not based on other works, etc, – it has a happy and positive message. I know that doesn't really mean much in today's world.
Fri 27 Jan 2012
It means right around $5500 for 3 years. A pretty accurate quote.
Sun 29 Jan 2012
I recently paddled the 740-mile Northern Forest Canoe Trail and took video along the way. I conducted interviews, got action footage, scenic shots, etc. The one thing I didn't do was get location releases. My footage was filmed on public waterways, public streets and a few private campgrounds. Will this be a problem if I try to distribute the film or show it publicly. Which locations would require release? It's my understanding that the footage on public lakes, rivers and streams, I'd be allowed to use. What's the consequence of not having a location release and then showing the film?
Sat 4 Feb 2012
Hello, I just joined D-Word. I have a question. Does anyone know of footage of Nice, France in the mid- to late-1920s? Also, footage of the Ottoman Empire in the early 1920s? I am looking for these to incorporate into a planned documentary on the life of the Ottoman Royalty when they went into exile. I can be reached at arvindach[at]gmail[dot]com. Thanks in advance. This looks like a very supportive community, judging from the answers to various questions asked by others.
Sun 19 Feb 2012
Hello All: Can anyone recommend a good, inexpensive video stabilizer for my Canon t3i? I've been looking at the Dot Line DL-0370 Hands-free Video Stabilizer but don't know anyone who has one. Thanks!
Mon 20 Feb 2012
Lillian, you'll find this and a lot more in this article from Chris Jones, 'The Perfect Guerilla Film Makers Camera Kit For Under £1k':
Hope this helps,
Yacine Helali
Mon 20 Feb 2012
Thank you very much Yacine!
Lillian Baulding
Tue 21 Feb 2012
In reply to Arv Acharya's post on Sun 5 Feb 2012 :
i was just watching the bbc doc the first world war. lots of stuff from the ottoman empire – might want to see their sources and see what else you can dig up.
the episode is jihad – its also on youtube
Tue 28 Feb 2012
Hi Everyone,
I'm in a very similar situation to Mike above. I recently filmed a short doc about a small-time rock band in the UK, the first half of which was filmed in a rehearsal studio that they frequently use. I phoned the managers of the studio prior to filming and they said that they were happy for me to film there and take shots of their building.
However, during the first day of shooting there, they refused to sign a location release. They said that they were still very happy for me to film there and that I could film what I wanted and do what I liked with the final film. They didn't want to sign anything however, as they felt this would, potentially, leave them exposed to me later using the footage in a way that was damaging to them. I've spoken to them a couple of times since filming, as have the band, but they're sticking to this line. Apparently bands film at their studio quite frequently and this is the stance they take in all cases. I'm a stickler for crossing t's and dotting i's legally, so am not comfortable accepting verbal consent alone.
I'm planning on putting the film up on Youtube and Vimeo. I have no current plans to send it to festivals or secure broadcast distribution. Is this lack of a written location release something I should be worried about? My specific questions are:
Could the studio hypothetically take legal action simply because I have filmed on their premises, or would they need to show that I have damaged their reputation in doing so etc?
Would it be possible for me to put the video online and ask them to sign a release form just for that edit of that film (ie so that I'm covered, but they are also reassured that I can't then go and re-edit the rushes into something damaging to them).
I am in the UK and the doc was filmed here. I have signed releases for the other locations, all identifiable contributors and all the band's music.
Any thoughts would be hugely appreciated – this issue's held the film up for too long! Thanks a lot!
Tue 28 Feb 2012
Personally I'd put it on the web and forget about it. Secondly, I think it's only broadcasters that require such extensive paperwork, not even festivals, generally. However, hypothetically any studio or any person could take legal action at any time for any reason whatsoever.
Tue 28 Feb 2012
Edited Tue 28 Feb 2012 by Doug Block
If it were me, I wouldn't worry about it a bit, Damien. But if it's keeping you up at night, you might want to get something informal with them via an email, even if it's just to explain their rationale as to why they don't want to sign a formal release. At least it's something where they state it's ok for you to film. But it's very unlikely they'll now turn around and sue.
Tue 28 Feb 2012
Thanks a lot Jill and Doug, I really appreciate your thoughts.
I doubt this makes a difference, but I forgot to mention that I did not include the studio's name anywhere (eg interviews, on-screen text or shots of signage). It would be recognisable only to those who are already familiar with it.
That's very useful info (and good to know) about festivals Jill, thank you.
Thanks a lot for that suggestion Doug. I'm planning to email each contributor/location individually as soon as the film is uploaded with a link and message of thanks for their help. With the studio I thought I'd add a note saying that I appreciate their desire to look after their reputation and invite them to watch the film and let me know immediately if they have any objections. If they do not have any then at least I can move forward with evidence that I've taken reasonable steps to consider and account for their interests even without a signed release.
Thanks again both!


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And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
This rectangular soap is made with all natural clear glycerin soap base. Organic rose petals have been gently sprinked on the back. Soap is scented with fresh cut grass, fresh cut rose, cedar wood, and magnolia. Bar weighs 6 oz. and can be used all at once or cut in half for a smaller bar.
This product ships from the maker within 7 days, via USPS
Unused and unopened items may be returned within 14 days


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fluorouracil topical (generic name)
Efudex (brand name)
It is used on the skin to treat skin cancer and skin conditions that could become cancer
(flure oh YOOR a sil)
Table of Contents
Top Learning Centers(Recursos en Español)
What is this medicine?FLUOROURACIL, 5-FU (flure oh YOOR a sil) is a chemotherapy agent. It is used on the skin to treat skin cancer and skin conditions that could become cancer.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
How should I use this medicine?This medicine is only for use on the skin. Follow the directions on the prescription label. Wash hands before and after use. Wash affected area and gently pat dry. To apply this medicine use a cotton-tipped applicator, or use gloves if applying with fingertips. If applied with unprotected fingertips, it is very important to wash your hands well after you apply this medicine. Avoid applying to the eyes, nose, or mouth. Apply enough medicine to cover the affected area. You can cover the area with a light gauze dressing, but do not use tight or air-tight dressings. Finish the full course prescribed by your doctor or health care professional, even if you think your condition is better. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, only use that dose. Do not apply extra doses. Contact your doctor or health care professional if you miss more than one dose.
What may interact with this medicine?Interactions are not expected. Do not use any other skin products without telling your doctor or health care professional.
What should I watch for while using this medicine?Visit your doctor or health care professional for checks on your progress. You will need to use this medicine for 2 to 6 weeks. This may be longer depending on the condition being treated. You may not see full healing for another 1 to 2 months after you stop using the medicine.
Treated areas of skin can look unsightly during and for several weeks after treatment with this medicine.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
What side effects may I notice from receiving this medicine?Side effects that you should report to your doctor or health care professional as soon as possible:
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Where should I keep my medicine?Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Keep container tightly closed. Throw away any unused medicine after the expiration date.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


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The 10 Most Amazing Exercises From 'The Mighty Marvel Strength And Fitness Book'
In the 22 years that I've been reading comics, I've built up a collection with some pretty weird stuff in it: A pristine copy of "Godzilla vs. Barkley" (in which Godzilla rises from the ocean to do battle on the court with a 300 foot-tall Sir Charles), a copy of "Rock Reflections of a Super-Hero," even the two comics about Prince that Dwayne McDuffie wrote back in the early '90s. But of all the weird ephemera I've got laying around, this is one of my favorite pieces:
The Mighty Marvel Strength and Fitness Book!
Released in 1976 by writer Ann Picardo and artist Joe Giella, the "Strength and Fitness Book" was an attempt to whip the ever-widening youth of America into shape by illustrating simple exercises as performed by everyone's favorite Marvel heroes. The end result wasn't just an exercise manual, and it's every bit as strange as you'd expect from something called the "Mighty Marvel Strength and Fitness Book," which is why I've gathered up my ten favorite pages!


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In Memory of Walter Martin (1928-1989): The Original Bible Answer Man, Part 2 (of 3)
In Memory of Walter Martin (1928-1989): The Original Bible Answer Man, Part 3 (of 3)
Have you ever had a Jehovah's Witness knock at your door? Perhaps it's just me, but they always seem to come to my house at the most inconvenient times.
The first story I ever heard about Walter Martin involved turning the tables on the Jehovah's Witnesses. The story is that Martin, a native of New York City, went to the headquarters of the Watchtower Bible and Tract Society located in Brooklyn. He knocked on their front door and began witnessing to them about the Jesus Christ of historic Christianity. What's good for the goose is good for the gander. Martin had what my Jewish friends call "chutzpah." I had the distinct privilege of working with and for him at the countercult organization he founded, Christian Research Institute, in the late 1980s.
In light of the 20th anniversary of Martin's death (June 26), I'd like to share six things I learned from his example as a gifted and accomplished Christian apologist. These lessons have been enormously helpful in my own trek through the challenging Christian apologetics enterprise.
1. Rhetorical Eloquence
Like one of his favorite politicians, President Ronald Reagan, Martin was a great communicator. He mastered the media venues of radio and television in order to convey the Christian message with clarity, intelligence, and force. Martin was one of the finest public speakers I have ever heard. Amazingly, he could speak extemporaneously and nevertheless speak in complete, grammatically correct sentences. He was always a very hard act to follow.
While few can match Martin's gift and skill of rhetorical eloquence, his example challenged me to concentrate on speaking in a clear, concise, cogent, and compelling manner. I call this the "four C's of communication." I encourage would-be apologists to work at sharpening their rhetorical skills. As Martin proved, eloquent speaking is a powerful vehicle in persuading people of the truth of the gospel.
2. Courage Under Fire
Courage is the classic virtue I admire most. That's probably why I greatly admire noble warriors. Courage is a rare trait both in the Christian church and outside of it. But Martin exhibited a great deal of courage in his apologetics ministry. He wasn't afraid to take a tough stand on a controversial issue and live with the repercussions.
Some people vigorously criticized Martin when he asserted that Seventh-day Adventism and Roman Catholicism shouldn't be categorized as non-Christian cults. For the record, Martin did not give either church body a clean bill of theological health and criticized both belief systems. Martin did his homework and was willing to absorb criticism from all sides.
As one of his research assistants, I adopted and defended Martin's views on Adventism and Catholicism. Accordingly, some of Martin's critics also publicly criticized my positions. While it's never easy for a Christian apologist to enter into the arena and take the heat, aspiring apologists need to know that facing criticism comes with the apologetic territory.
Though he has a different temperament and labors in a different part of the apologetic vineyard, Hugh Ross exhibits Martin-like courage in defending old-Earth creationism. Yet Martin himself affirmed old-Earth creationism long before it gained popular support.
In part two of this article I will discuss two more apologetic lessons that I learned from my former boss and apologetics mentor, Walter Ralston Martin.
For more information about Martin's books and taped lectures, see Walter Martin's Religious InfoNet.
|Part 1 | Part 2 | Part 3


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My name is Kat. I love smiles, life, and sparkles. My best friend is Beverly, check her out on here as Babee. She's my other General
Mon, Dec 27, 2010 at 2:01 PM
Happy Holidays!
I haven't been on in a few days, but I wanted to wish everyone Happy Holidays! We got a ton of snow here so if you live anywhere near Delaware, especially in Jersey and New York I hear, be very careful! On another note, what did everyone get? My boyfriend gave me my Pink 4 Friday lipstick, I was soooo hype. He also gave me a gorgeous necklace, and Metalocalypse season 1 to go with my season 2...


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Leading into the 20th century, human sexuality was a thing of taboo—for the word "sex" to be uttered aloud was uncouth, and a woman showing more than a bare ankle was instantly dubbed a harlot.
Thankfully, as shown by SFR's current special issue, things have changed a tad since then.
Some sex historians might argue that we have the modern concept of the pin-up—tantalizing and suggestive sexy lasses of the day—to thank for that. Armed with more hairspray and polka-dotted garb than that found at one of my chola cousin's cookouts, the Bettie Pages and Betty Grables of the day reclaimed their God-given sensuality and gave many a GI company something else to think about during WWII.
Taking a page from their book—or, in this case, Varga-illustrated mag—artists Carrie Tafoya and Ungelbah Dávila joined forces for a pin-up-tastic multimedia exhibition that opens this Friday at Eggman & Walrus.
Dubbed Pinup-ology, the exhibit features over 40 original photographs and live rockabilly performances courtesy of The Shadow Men and Mr. Right and the Leftovers.
"We wanted to do things differently for our opening," Dávila tells SFR. "It's going to be more than your standard wine and cheese thing."
Also at hand, live pin-up models are set to work the room in vintage and original designs by Tafoya, providing the evening's "eye candy."
"We sought to create an overall mid-century ambience," Davila says.
Though flirty and fun, some of the images in the show, like "At Arms," (pictured) have a deeper meaning.
"I had the vision of a psychedelic '60s war protest picture," Dávila, who snapped the shot, says. Later, she would find out that the model pictured is an Operation Iraqi Freedom vet, which added another layer of depth to the image.
For Dávila, pin-ups and rockabilly are a way of life, so much so that in 2010 she created a publication called La Loca. She hopes that this exhibit brings the lifestyle to a broader audience.
"I really enjoy the wholesomeness of it," she says. "It was the last time [that] females were being flirtatious and coy without being extreme or pornographic…it's empowering!"
6-11 pm Friday, Feb. 8 Eggman &Walrus Art Emporium
130 W Palace Ave., 660-00


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|Snow White vs Evil Queen? Who is the Fairest of them All?
The new film, "Snow White and the Huntsman" hitting theaters now, certainly gives a new meaning to the fairy tale.
Have you seen the movie? Talk about taking the Snow White tale to new heights.
Soap Tweets
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Edward Klimczak, Director of Talent Acquisition at Masimo Corporation says the current candidate pool is very rich. "In a down economy with the national unemployment rate hovering around 10%, there are many people looking for job opportunities at stable, growing companies like Masimo," he says.
Of course, Klimczak says this means that recruiters have to look through a lot more resumes than usual to find the skill sets they're looking for—"making it increasingly important that a candidate's resume specifically addresses the skills required by the job as listed on the position description," he says.
Masimo is one of the few companies that actively recruiting at the moment. The medical device company is slated to add 100 new positions to a third building in Irvine, California. Most of the openings will be focused on field sales representatives and engineering positions at all levels. But, there will also be openings in regulatory, clinical research, quality and a few other corporate areas.
In such a tight job market, it helps to know what sort of questions the recruiters are asking. When interviewing, Klimczak says his top 5 interview questions when recruiting a candidate are the following:
1. What do you know about the company and why do you want to work for it?
2. What are you looking for in your next career move?
3. Tell me about one of your most challenging career obstacles, what steps you took to meet the obstacle, and what was the outcome?
4. What are your greatest takeaways from your previous employers?
5. Why do you want to leave your current/previous employer?
But, the answer to these questions is not all Klimczak is looking for. What he is truly looking for is a glimpse into candidates' professional motivations, career aspirations, how they approach their job, and what they have learned from past experiences.
In particular, "I want to understand why they are looking to make a move and their motivation for wanting to join Masimo," he says, "is it for a salary increase, career advancement, a change of pace or environment, or because they envision being part of something new and different?" he questions.
Klimczak also wants to get a sense of a candidates' work ethic, the level of passion they have for what they do, and in what settings they feel they work best. "More often than not, it is how they say or frame their answers versus just the content of their answers that matters most," Klimczak says.
According to Klimczak, what a candidate says tells him if they are articulate, have well organized thoughts, can convey their answers in a clear, concise manner, and how they approach and overcome obstacles. "How they respond tells me how passionate they are about what they do and the job they are applying for," he says.
Interestingly, when the answers don't flow naturally or address the specific question asked, Klimczak says it can seem as if the candidate has been coached or is reading from a script. Also, he says if a candidate's answers are "too canned" or "executed flawlessly," it can give the impression that they are staged.
Klimczak typically designs his interview questions based on the requirements of the position, department, the personality of the team or group, and corporate culture. "Based on the candidate's resume and what I know of them, I design additional questions that speak to their learning ability, leadership ability, and the skills and successes they bring to the position now and into the future," he says.
If you are currently unemployed, Klimczak says to treat your job search as if it were your full-time job. "Pull out all the stops and take it seriously," he says, "have a professional, upbeat telephone greeting on your cell and home numbers, and get your resume out to as many people as you can."
He encourages candidates to talk to as many recruiters as possible, tap into your network of colleagues and friends, post your updated resume on job boards. He also says to consider being open to relocating if necessary. "This is no time to be shy, pick-up the phone and start dialing," he says, "But, above all else, stay positive!"
Klimczak's best advice for a recruiter is to network and seek out. "First, utilize your own internal network and resources," he says, "our recruiting team is comprised of seasoned professionals with many years of experience, so we bounce ideas, approaches, and sourcing techniques off each other all the time."
Next, he says to seek out input, feedback, best practices, and information from external networks and resources, such as industry colleagues and employers. "The goal is always to attract top talent, which means keeping your recruitment feelers out there and your finger on the pulse of the industry," he says.
As many know first-hand, recruiting has been very limited over the course of the last year across the life-science industries. Georgia Key Smith, Director of Human Resources at Watson Pharmaceuticals, Inc. (JOBS) in Corona, Calif. says last year was very slow on the recruitment front, but there presently several key openings within the company.
Like Klimczak, Smith says the candidate pool is also pretty rich at the present time. "However, we have to weed through an awful lot of unqualified applicants," she says, "there's such unemployment, that people will apply for anything whether they are qualifies or not."
She suspects the reason is so people get their foot in the door, but she says it just makes a lot of work for recruitment. For any one job, she says it's not atypical to get 300 applicants. "I've not quite seen it like this before," she says.
As for the interview process, Smith says a candidates' knowledge, preparedness, and on target, or lack of, response is very critical in the process. By knowledge, she is expecting them to know something about the role, a bit about the company, and demonstrate expertise in the role in question.
One of the pit-falls she says recruiters need to avoid is judging a candidate in the first few minutes of an in-person interview. She says it's easy for less-skilled recruiters to be swayed by personal appearance. "It's something you have to really guard against," she says.
As for advice to candidates, she says to "be prepared, be through, know your stuff, be verbally skillful, and be able to communicate effectively."
Using common sense is also important during the interview. One of her top questions to candidates is why he or she is applying for a specific position.
Unbelievably, she says she often gets replies that have to do with the company being closer to home. "A director-level candidate said that to me not that long ago," she laughs. She has heard similar responses from more than one candidate in the past.
While actual recruitment strategies don't vary too much depending on the size of the company, Salvador Rivera, Director of Human Resources at Amyris Biotechnologies, Inc. says often the recruitment process is different for start-up companies compared to larger companies.
"At start-ups, there are fewer resources, recruiting budgets are smaller, and the employment proposition is a bit different from a large pharma that has all the mature bells and whistles," he says.
From a wealth creation prospective, Rivera says large pharma companies often offer perks such as matching 401K plans, employee stock programs, and even pension plans at some of the European based companies.
At a start-up like Amyris, Rivera says an employment proposition is centered on a candidates' ability to work in a fast-pace environment. "We're doing something for the first time—that creates an unprecedented opportunity to make a quick impact in the work that we're doing," he says, "at larger companies, it's a bit more difficult to get traction on the impact you want to make on the company."
Amyris is currently very stable with its employee count and all the job functions and are at capacity. "That doesn't mean that we won't be recruiting for replacement positions and some new positions as a result of some business and scientific activity, namely the receipt of a federal grant recently," Rivera says.
The funding has prompted human resources to look for individuals who can manage the grant, including accountants and administrators, and people that may be needed in the scientific and technology groups as a result of the grant work the start-up will be doing.
For Rivera, the top question to candidates is finding out what they are looking to gain from their next position. He says it's important to know this to ensure the company can meet those expectations, and to make sure the position is a proper match in terms of what the candidate is seeking.
His other top questions are geared to making sure a candidate will be compatible with life at a start-up company. "It's a faster pace, there's much more need for innovation, autonomy, self-motivation and direction," he says, "and teasing out whether a candidate is not only compactable with those characteristics but it willing to engage in what needs to be done is essential," he says.
Rivera says past-performance is always the best predictor for future performance, and so the design of his interview questions usually fit that framework.
As for advice to recruiters or hiring managers, Rivera says it's important to spend more time up front defining the role. This means going beyond the job description and involves defining the success factors for the position that's open.
He also says it's important to have an organized approach to the interview rather than open-ended conversation. He says a lot of scientists and engineers are systematic in their work and he encourages them to bring this methodology to the recruitment arena.
"Designate specific roles to the interview team members so they don't repeat conversations," he says, "that way everyone brings consistent information that can be assembled together to make the best selection possible."
Read the Career Insider online newsletter January 28, 2010.
Sign-up for the free weekly subscription to the Career Insider.


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Medications for Chronic HIV: Education and Collaboration (MedCHEC)
This study is ongoing, but not recruiting participants.
Boston University
National Institute of Mental Health (NIMH)
VA Office of Research and Development
VA Boston Healthcare System
VA Greater Los Angeles Healthcare System
San Diego State University
Tufts University
Information provided by (Responsible Party):
Allen L. Gifford, Boston University
ClinicalTrials.gov Identifier:
First received: December 19, 2009
Last updated: March 29, 2017
Last verified: March 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This study will examine whether a computerized, self-administered assessment of patient medication adherence and health behaviors, plus support for adherence, improves the ability of clinicians to identify adherence problems and leads to better adherence.
|HIV Infections Acquired Immunodeficiency Syndrome Medication Adherence
|Behavioral: MedCHEC Tablet Computer & Adherence Care
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
|Official Title:
|Implementing Computerized Clinical Assessment of HIV Patient Adherence
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDSU.S. FDA Resources
Further study details as provided by Allen L. Gifford, Boston University:
Primary Outcome Measures:
- Patient adherence to HIV medications, as measured by MEMS data, and by self-report questionnaires. [ Time Frame: 1 year ]
|Estimated Enrollment:
|Actual Study Start Date:
|December 2009
|Estimated Study Completion Date:
|December 2017
|Primary Completion Date:
|June 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: MedCHEC Tablet Computer & Adherence Care
Patients assigned to the intervention answer questions about their medication, medication-taking behavior and risks for non-adherence on the MedCHEC tablet touch-screen computer, which generates provider and patient reports. Patients may be referred to an Adherence Care Manager on the basis of the reports. In addition, patients will receive standard information about adherence.
Behavioral: MedCHEC Tablet Computer & Adherence Care
Patients answer questions about their medication, medication-taking behavior and risks for non-adherence on the MedCHEC tablet touch-screen computer, which generates patient and provider reports. Patients may be referred to an Adherence Care Manager on the basis of the reports.
Other Names:
No Intervention: Adherence Information Only
Patients assigned to the active comparator arm will receive standard information about adherence.
Detailed Description:
Antiretroviral medications are highly effective in controlling HIV, if patients adhere to the regimen. However, HIV medication adherence problems are very common, and evidence is clear that providers have great difficulty 'diagnosing' poor adherence accurately. If healthcare providers can identify patients with adherence problems, they can intervene to help patients overcome these problems and take their medications as prescribed, which can improve symptoms and quality and length of life. Both clinicians and HIV positive patients will be recruited to this study. Before each clinic visit, patients randomized to the intervention will be asked to answer questions about their medications, medication-taking behavior, and risk-factors for non-adherence on MedCHEC, a tablet touch-screen computer that generates provider and patient reports. We will give these reports to the provider and patient to assist with the clinical visit. Based on the MedCHEC-generated report, the patient may be referred to an Adherence Care Manager (ACM). The ACM will assist the patient in overcoming adherence barriers by telephone and in-clinic counseling. The study will evaluate the effects of this system on adherence and clinical care using both quantitative methods (randomized controlled trials of effects on adherence and providers' adherence estimates), and qualitative methods.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Over 18 years of age
- Confirmed HIV-positive
- On or newly starting antiretroviral medication for HIV
- Under treatment at one of the study sites
- Available by telephone
Exclusion Criteria:
- Clinically diagnosed by provider with significant cognitive impairment, or Mini-Mental Status Exam score less than or equal to 22
- Inability to read English
- Inability or refusal to use MedCHEC touch-screen computer
- Inability or refusal to use any form of electronic drug monitoring device (MEMS)
- Never available by telephone
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01038076
Please refer to this study by its ClinicalTrials.gov identifier: NCT01038076
|United States, California
|VA Greater Los Angeles
|Los Angeles, California, United States, 90073
|United States, Massachusetts
|VA Boston
|Boston, Massachusetts, United States, 02030
|Boston Medical Center
|Boston, Massachusetts, United States, 02118
Sponsors and Collaborators
Boston University
National Institute of Mental Health (NIMH)
VA Office of Research and Development
VA Boston Healthcare System
VA Greater Los Angeles Healthcare System
San Diego State University
Tufts University
|Principal Investigator:
|Allen L Gifford, M.D.
|Boston University School of Public Health and School of Medicine
More Information
Keywords provided by Allen L. Gifford, Boston University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
|Responsible Party:
|Allen L. Gifford, Professor of Public Health and Medicine, Boston University
|ClinicalTrials.gov Identifier:
|NCT01038076 History of Changes
|Other Study ID Numbers:
R01MH076911-02 ( U.S. NIH Grant/Contract )
|Study First Received:
|December 19, 2009
|Last Updated:
|March 29, 2017
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Keywords provided by Allen L. Gifford, Boston University:
Complementary Therapies
Adherence Care Manager
Additional relevant MeSH terms:
HIV Infections
Immunologic Deficiency Syndromes
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immune System Diseases
Slow Virus Diseases
ClinicalTrials.gov processed this record on September 25, 2017


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This week Paul Coyle takes a look at the recent court decision of $11.4 million to be rewarded to Truck America by the City of Hillview.
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FOREST Green boss David Hockaday has distanced himself from the vacant manager's job at Swindon Town.
He is one of the favourites to take over at his former club after Paolo Di Canio resigned earlier this week, but insists he has no intention of leaving Rovers.
"I haven't been approached. I'm employed by Forest Green Rovers and I love my job," he said.
"I've got the best chairman in the world and a job to do at Forest Green. I am very happy at the club.
"I'm Forest Green through and through. If ever my chairman wants me to leave then that's a different matter but until such time I'm happy here.
"I've got a great group of lads here and we're building something special."
Hockaday, 55, represented Swindon more than 300 times over the course of a long and distinguished career in Wiltshire, during which he won promotion with the Robins from the old Division Four in 1985/86 and Division Three the following year.
His stock is understandably high after guiding Rovers to fourth in the Blue Square Premier table, just five points behind leaders Wrexham.
Although Hockaday's odds have drifted slightly, with Paul Buckle emerging as the hot favourite after resigning manager of Conference rivals Luton Town on Tuesday, he is still as short as 5/1 to become the next Swindon manager with Bet Victor. Di Canio's former assistant Fabrizio Piccareta was in charge for the 3-1 win over Tranmere that lifted Swindon to the top of League One on Tuesday night, but has since left the club.


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On an average day, the United States Postal Service® handles enough mail to circle the globe three times. Just imagine how much more they handle during the busiest time of year—the holiday season. From packages to holiday cards and letters, there's a mind-boggling amount of mail that goes through the system. But with that much volume, a small portion of mail may get lost or not arrive in time. Is there anything you can do to make sure your mail doesn't get lost in the shuffle?
Tips for Holiday Mail
For starters, use printed labels. They're easier to read than handwriting. Include the complete ZIP Code with the address on every package or letter you send. If you've got a large mailing, pre-sort your outgoing mail by ZIP Code. And make sure you get it done early, so you can beat the holiday rush.
You can also create a nice presentation of your mailing with a label that sets the tone. Whether it's formal and professional, or warm and friendly, use labels to help recipients form an impression of what they received.
Go from Mailing List to Labels in No Time
Creating your own printed labels is easy. Start by downloading the Avery Wizard for Microsoft® Office for free. With the Avery Wizard and Avery Labels, you can create address labels from your mailing list in no time. The Avery Wizard gives you simple step-by-step instructions so you can do a mail merge, format, customize and print your labels in a snap. You can launch the Wizard from wherever you keep your mailing list, whether it's Microsoft® Word, Excel®, Outlook® or Access®. If you don't have a spreadsheet with all of your names and addresses, you can start with our pre-formatted files for Microsoft® Excel or other database programs.
Customized Labels Made Easy
Avery Wizard has a host of features to help you design and customize your labels. You can insert, move and resize company logos or other graphics. Change the font type, color or size. You've got the flexibility to be as creative as you want to be. You can even add a company logo to your mailing label.
This year, spend just a little extra time creating mailing labels that easy to read, customized and ready for the Post Office™. Use the free Avery Wizard download and Avery Labels and get your holiday mailings off to the right start.


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FutureThe advantage of our system is that large quantity of substances can be released at the desired timing and place.
Utilizing our system, we can note the effective treatment for cancer. Controlling the timing and place would prevent the side effects by anti-cancer agent, and releasing large amount of drug by a small quantity of triggers offers the effective treatment for cancer.
Moreover, focusing on the chain reaction, our system can be applied to long-lasting batteries for molecular engines. If some fuel for molecular engines (such as ATP) is packed inside the liposome, and the liposome is combined with some molecular motors (such as motor proteins), the fuel can be constantly supplied to the molecular motor by only one time initiation of the reaction.
The molecular motor would lead to molecular engines, and in the end, sophisticated molecular robots. Our system would make it possible to achieve molecular robots moving without continuous fuel supply from the outside.
Fig1.Attack to a cancer cell
Fig2.Molecular engine


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Open A11y Conference Call: Agenda for 2009/06/16
IMPORTANT NOTICE TO PARTICIPANTS: Our previous teleconference numbers and passcodes are no longer valid! Teleconference services for the Open A11y Work Group are now provided by rednote.net. Three options for dialing in are described in the Logistics section, below. No passcode is required (at least, for now). If you have any trouble callling in, remember that the
#a11y channel will be open on irc.a11y.org (channel #a11y) during the teleconference, so you can always ask for help via IRC.
Announcing the 16 June 2009 meeting of the Open Accessibility (A11y) Workgroup. The meeting begins promptly at 1500h UTC; you can find your time zone using the Fixed Time Clock. Please RSVP, as it will help us start the meeting without unnecessary delay. Information about meeting logistics, including dial-in and IRC information, follows the agenda.
- Welcome and Agenda Review
- Review of: minutes from the 9 June 2009 Open A11y call
- Old Business
- D-Bus Port Progress and Issues
- SIG Updates (conditional)
- Website Updates (conditional)
- New Business
- Identify items for the 23 June 2009 teleconference
- Adjourn
Meeting Logistics
- Tuesday, June 16, 2009 at 15:00 UTC
- find your time zone using the Fixed Time Clock
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#a11ychannel will be open on
#a11y) during the teleconference.
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Three Ways to Dial in to the Open A11y Conference Call
There are three options for dialing in to Open A11y calls; Note that '''No''' passcode is required (at least, for now)
- Direct worldwide access using any SIP client:
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2119*984(that is: 2, 1, 1, 9, star, 9, 8, 4)
- the complete ITAD Directory, as well as more information about ITAD and TRIP is also available from IANA
- Note: that your ITAD installation may require an ITAD access service code;
- Example: At MIT first dial
2119*984(that is: 2, 1, 1, 9, star, 9, 8, 4)
- Example: At MIT first dial
- Free of charge in many localities worldwide via SIP Broker's PSTN to SIP gateway service as follows:
- Find a local telephone number from sipbroker's list;
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- At the SIP Broker prompt enter:
*8390 2119(that's star, 8, 3, 9, 0, 2, 1, 1, 9)


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After you pick the day you want to be married and secure the church, temple or place for the ceremony and reception, the next thing you want to get right on is your caterer. We often get booked over a year in advance for weddings, so please call your company as soon as you can.
What do you want to look for in a caterer? Someone who treats you and your day with respect and seriousness, and who gets back to you promptly. You want a person with knowledge and calmness. You will want to have a tasting to work out the idiosyncrasies of the menu.
I immediately cross a person or company off my list who treats me as if they are doing me a favor or if they have too standard of a package. You know the feeling, and you should just move right on to the next person on your list if you get a bad vibe.
You will want one of the higher-ups to be there that night, overseeing the servers. I have worked at several weddings, serving beautiful desserts, where the catering company had servers who were drinking in the back, smoking at every chance they could get or had several slackers.
At one event, even the person in charge was the first to pop a beer as they were setting the table up. This is absolutely unacceptable behavior for any event, let alone a wedding.
On another note, this is not the norm, and most vendors want to give you the night of your life. Work with your caterer and planner and build up trust. When a caterer tells you that you need so many servers, this is not a place to skimp. The food, the celebration for your guests, is tantamount. You want great servers and the correct number.
You also need one good bartender for every 90-100 people. A great bartender is going to run approximately $20 per hour in Fort Wayne. Not all bartenders are created equal, so that should be one of the first people you secure. Word of mouth is the best, or word of your caterer or wedding planner.
Next, get your band or DJ, if you are having music.
Get your cake maker. A cake is generally priced by the slice and can run from $3 to $8 a slice, depending on if you want fillings and how fancy it is. It is a trend to make a "dummy" cake for presentation. This is a fake cake decorated to the nines. Then another cake is made for cutting for the guests, often less fancy.
I am not sure why this trend is happening, so please email me if you do. I was told because the smaller cake is easier for the servers to cut and serve. I personally do not like this trend, and the cake maker I recommend does not do this. It seems like an added expense.
A groom's cake is fun, but this is where you could cut if you are being frugal.
Some great places to start for ideas are: Martha Stewart (of course!); Pinterest; the book "Colin Cowie Wedding Chic" as well as his website, www.eastonevents.com; Sylvia Weinstock's website, www.sylviaweinstock.com/index_fl4.html; wedding magazines; and a whole slew of websites.
Do not watch "Bridezillas" (on WE tv) and fill your head with that nonsense! I recently read an article in the Wall Street Journal where a reader was sent a horrible note from a bride and groom because they thought her gift was too "cheap."
Remember, while most guests will give you a wedding gift, it is a gift, not an obligation. Some things will be exactly what you want, some will be homemade, some might be re-purposed and some might be a "whhhhhhat?" but all are gifts and deserving of your heartfelt thanks.
I know you have great manners and will write thank-you notes to everyone. Please handwrite them and absolutely do not email them. If a lot of your guests are co-workers, don't hand them their thank-you notes or put them in their work mailbox. That is uber tacky. A gift is deserving of a stamp and a thank-you note received in the mail. You have a year, technically, but the sooner, the better. It looks more caring, and you don't want that chore looming over your head for 12 months.
Please email The News-Sentinel with any questions about this fun and stressful time in your life, and I'll get back to you. Have a wonderful wedding and enjoy your festivities surrounding it.
Let the people you hired handle the stress, and you just relax as much as possible and take this time in. Be thankful, be grateful and have fun!
Laura Wilson, owner of La Dolce Vita in Roanoke, is a Le Cordon Bleu-trained chef. She answers questions in The News-Sentinel every other Tuesday. Have a question for Laura? Submit it to email@example.com or call 461-8284. We'll pass on questions to Laura. This column is the personal opinion of the writer and does not necessarily reflect the views or opinion of The News-Sentinel.


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The Weekly Health Quiz: Migraines, Drinking and Belly Fat
September 22, 2017,
Chinese restaurant syndrome is a collection of symptoms that some people have after eating Chinese food. A food additive called monosodium glutamate (MSG) has been blamed, but it has not been proven to be the substance that causes this condition.
Hot dog headache; Glutamate-induced asthma; MSG (monosodium glutamate) syndrome
In 1968, reports of a series of serious reactions to Chinese food were first described. MSG was felt to be the cause of these symptoms. Since then, many studies have failed to show a connection between MSG and the symptoms that some people describe after eating Chinese food.
For this reason, MSG continues to be used in some meals. However, it is possible that some people are particularly sensitive to food additives, and MSG is chemically similar to one of the brain's most important chemicals, glutamate.
Chinese restaurant syndrome is usually diagnosed based on the symptoms. The health care provider may ask the following questions as well:
The following signs may also be used to aid in diagnosis:
Treatment depends on the symptoms. Most, such as headache or flushing, need no treatment.
Life-threatening symptoms require immediate medical attention. They may be similar to any other severe allergic reaction and include:
Most people recover from mild cases of Chinese restaurant syndrome without treatment and with no lasting problems.
People who have had life-threatening reactions need to be extremely cautious about what they eat and should always carry medication prescribed by their doctor for emergency treatment.
If you experience any symptoms such as shortness of breath, heart palpitations, chest pain, or swelling of the lips or throat, go to the nearest emergency room immediately.
Bush RK, Taylor SL. Adverse reactions to food and drug additives. In: Adkinson NF Jr, ed. Middleton's Allergy: Principles and Practice . 7th ed. Philadelphia, Pa: Mosby Elsevier; 2008:chap 66.


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Aug. 23, 2004
Olympian To Train Texas Teachers in Archery for Schools
AUSTIN, Texas — Texas teachers will have an opportunity to learn from one of the world's elite archers, former Olympic gold medalist Rod White, and pass those skills on to their students as part of a new National Archery in Schools program.
Texas Parks and Wildlife Department is seeking interested participants to be the first National Archery in Schools program instructors and teachers trained in Texas. The pilot workshop will be held in Austin, Sept. 14-16 at Ojeda Junior High School, next to the department's headquarters complex at McKinney Falls State Park.
The program, targeting middle and high school students, is a skills-based archery program emphasizing life-long opportunities. Started in Kentucky, and in only its third year, the program is now in 32 states and growing.
National and regional competitions have been held recognizing top schools and individuals but the program is geared toward teaching youngsters skills that involve discipline, focus, precision and fundamentals — like any sport.
"What's great about archery," according to Roy Grimes, the national director who helped developed the program, "is that everyone can participate and excel at the sport. Those inclined to go on and compete can do so; those that simply want to have fun can be involved, too."
Two levels of instruction will be presented during the three-day workshop. Advanced training will be offered during the first two days of the workshop for participants familiar with archery fundamentals, range setup and coaching techniques is designed for those who want to train teachers statewide in the program. The third day will focus on basic level training specifically for teachers wanting to use the program within their school curricula — primarily physical education, agriculture science and outdoor education courses.
As a popular Olympic sport, archery has enjoyed a renewed interest, especially among school children. "The program is really taking off and it shows that youngsters have an interest in archery as an integral sport taught in gym classes across the United States," said White. "Everyone can compete, everyone can be successful, and everyone can have fun learning how to shoot with bow and arrow."
The archery course can be set up in a school gymnasium in a safe, easy fashion, and the equipment is available at reduced rates to teachers. TPWD is providing loaner sets to the first 10 pilot schools. Other schools that come on board will be able to purchase the basic sets at the reduced rates directly from the manufacturers sponsoring the program at the national level.
Grimes summarized, "Educators love the program because it engages a large percentage of the student body in the educational process — early data demonstrate that attendance, behavior and self-esteem are improved through this program."
The maximum number of participants for both training units is 20, and reservations will be taken on a first-come-first-served basis. Those who do not get into this pilot opportunity will be placed on a list for future training workshops to be conducted throughout Texas.
There is no cost for this pilot program except for lodging and some meals. TPWD is covering the cost of the instruction, materials and lunches, sponsored by the Texas Hunter Education Instructor's Association.
Free lodging is available upon request, but is farther away from the hotels located a few minutes from the school.
If you would like to be included, please call Steve Hall, education director, Texas Parks and Wildlife Department at (512) 389-4568 or e-mail him at email@example.com. The program is part of the state's hunter and bowhunter education efforts; programs that are supported from the sales of archery equipment through the U.S. Fish and Wildlife Service's "Federal Assistance in Wildlife Restoration" efforts.
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Petition Launches for GWAR to Perform at 2015 NFL Super Bowl Halftime Show
Finally there's a petition we can all get behind. Regardless of political ideology, socioeconomic status, race or religion, we can all agree that GWAR deserves to perform at the 2015 NFL Super Bowl Halftime Show.
GWAR and the NFL share the exact same target audience. Chest-pounding, beer-drinking, hot wing-devouring dudes with pot bellies don't want to have their buzz dimmed by poppy garbage during halftime of the Super Bowl. The Black Eyed Peas stunk the place up in 2011, Madonna didn't fare much better in 2012 and Beyonce filled up time at this year's halftime show. Bruno Mars has been revealed as the 2014 Super Bowl halftime show performer, and in response, rock and metal fans rolled their eyes for the fourth consecutive year. We need a kick-ass metal band to shake the Earth during halftime at the Super Bowl, and GWAR is the perfect band to invade that stage.
A petition has been launched via Change.org with the goal of delivering everybody's favorite intergalactic alien scum to the 50-yard line of Super Bowl XLIX. "The time for GWAR to address the nation is NOW," begins the petition. "GWAR's relationship with American football is one of the strongest in music. Why should articles like "Bruno Mars Announced For Super Bowl Halftime Show, Gwar Waits Until Next Year (Again)" be a joke? Front man Dave Brockie writes a football collumn for Metal Sucks.com called "Necessary Roughness" even the "The Dan Patrick Show" has an Oderous mask on display. It's even been suggested by Sports Illustrated that GWAR should become mascots. Every year people complain about who the halftime show is, now we are telling you who we want: WE WANT GWAR!"
Join the good fight by heading over to Change.org and committing your name to the cause … NOW!


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Aug. 24, 2007
1st Alamo Extravaganza "Celebration of Choices" Sept. 15 in San Antonio
SAN ANTONIO — Turning Point, San Antonio Parks and Recreation Department, Texas Parks and Wildlife Department, Texas Wildlife Association and other partners will host the 1st Alamo Extravaganza "Celebration of Choices" Sep. 15 in San Antonio, providing a setting for people with disabilities to experience fishing, climbing, shooting, kayaking and many other outdoor activities.
The event takes place 9 a.m.-4 p.m., Sat., Sept. 15 at Woodlawn Lake, 1103 Cincinnati Street.
Activities will include Archery, Scuba, Bowling, Handcycles, Bass Fishing, Climbing Wall, Kayaking, Catfish Tank, Sailing, Air Rifles, Fly Fishing, Fencing, Laser Shot, Remote Control Cars, Golf, Casting, Disc Golf, Academy Camping Area, Rugby Demo, Tennis, Horseback Riding, Petting Zoo and Face Painting.
The City of San Antonio Parks and Recreation Department is hosting the event. Texas Parks and Wildlife Department is arranging archery activities, air rifles, fly fishing, catfish stocking and other assistance. The Texas Wildlife Association is also a major event sponsor.
Event visitors have a chance to win thousands of dollars in outdoor equipment. For every activity visitors participate in, they will receive a ticket for a drawing to give away prizes.
Turning Point was founded in 1979 by Michael "Shorty" Powers. After an injury at age 17 left Shorty without the use of his legs he began looking for opportunities to become involved in the outdoor recreational activities that he had always loved. He found no organized activities that were available to people who had major mobility impairments. Not willing to give up his love of fishing, kayaking, scuba diving and hunting, Shorty established Turning Point to assure that outdoor activities were readily available to people with many types of physical challenges.
Turning Point is a 501(c) 3 nonprofit organization designed to teach people with mobility impairments the skills necessary to fully enjoy the outdoors, and to provide free or low cost activities. Turning Point provides the encouragement and support needed for people who have major physical challenges in life to fully participate in the adventure of living.
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(5.4.16 i)


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Whiskey T-Shirts are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Whiskey T-Shirt for a special occasion, give a Printed Whiskey T-Shirt as a present or need to represent with a funny Whiskey Tee during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Whiskey T-Shirt for you! Even if it turns out you can't find the right Whiskey Tshirt with the perfect design for your mother, father or children; Idakoos offers all of its men's women's and children's Whiskey Tshirts as Custom Whiskey T-Shirts. Personalize any Whiskey T-Shirt the way you want to ensure the perfect gift.
Showing 1 - 24 of 48 T-Shirt


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