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|This book has doubled the weight of my carry-on luggage home
Sunday, 2 October 2011
The Most Essential Beer Book You Can Buy (apart from any of mine of course)
19 comments:
- Steve Lamond said...
I've got it on pre-order! Looking forward to it.
- 2 October 2011 at 18:07
- Rudgie73 said...
That's the Xmas list sorted then
- 2 October 2011 at 18:10
- Carsmile Steve said...
I am buying it for myself BEFORE Christmas so I can tell everyone I have it so I don't end up with three copies (or the Three Sheets To The Wind problem as I like to refer to it...)
- 2 October 2011 at 18:51
- Birkonian said...
£21.00 and free delivery on Amazon. You'd think I'd at least get a free copy from them for this plug (Chance would be a fine thing by the way).
- 2 October 2011 at 19:25
- realale said...
I have also pre-ordered this a month ago on Amazon UK. Waiting for 1st of Nov
- 2 October 2011 at 20:27
- Adrian Tierney-Jones said...
Birkonian — contributors don't get free copies, unless of course you made it to Denver and wore a big jumper (only joking Pete)
- 2 October 2011 at 21:10
- Cooking Lager said...
£21?? Do you know how much cheap lager you can buy for £21?
- 3 October 2011 at 11:51
Courage's Imperial Russian Stout is back! Kudos to Wells Young and everyone associated with this for making it happen. By far one of the most important brewing events to happen in recent years IMO.
- 3 October 2011 at 15:21
- Leigh said...
(adds to xmas list...)
- 3 October 2011 at 18:55
- Tyson said...
A good read, indeed. But, judging from the questions already raised over some entries, a second, revised, edition is already needed.
- 12 October 2011 at 15:15
I find it interesting that you complained about Stella getting the history of Cider incorrect in a marketing compaign, but you don't seem to have any issue with this book getting the history of British brewing wrong (http://zythophile.wordpress.com/2011/10/19/the-oxford-companion-to-beer-a-dreadful-disaster/#comment-27379). A marketing compaign I hold in less regard then a book, especially a book you consider "the most essential beer book you can buy".
- 22 October 2011 at 03:35
- Niall said...
As above. I'm gonna side with Martyn Cornell on this one. He researches extensively, cites his sources and is the most rigorous writer about UK beer that I've encountered. I haven't read the Companion, but based on the snippets quoted on other sites, I'm dubious about the historical content.
- 22 October 2011 at 23:34
- Pete Brown said...
If there are errors - there are bound to be! - help correct them by all means. But the online massacre of this book honestly makes me want to dissociate myself from beer writing. The glee and venom with which people jump on mistakes here and there, and use them to devalue the entire enterprise, is at odds with everything that attracted me to write about beer in the first place. As someone who has actually got a copy of the book, I stand by my claim that it's an essential purchase. There will be a second edition. Garrett is welcoming corrections for that - from people who can offer them in a civilised manner.
Oh, and Dave - my objection to the Stella cider ad was nothing to do with them getting the history of cider wrong - I don't think I even mentioned that - it was that the campaign patronises people.
I can see and completely understand that a book on beer may be of more interest to you personally than an advertising campaign. But the Stella cider ad will be seen by many more people, and will have a much bigger effect in society, and that's why I think it's more of a priority to write about.
- 24 October 2011 at 11:13
I loved the section of the real ales, my favourite ones.
Real Ale Record Book by Adrian Tierney-Jones is that kind of book i suggest you guys to buy. the second one would be about Belgian beers
- 25 October 2011 at 10:50
- Niall said...
I see you've edited your original response - indeed, you've tempered it significantly, so I'll refrain from replying to it, beyond calling attention to that.
It's specious to characterize a reader's stated preference for cited research in a text that outlines the history of given beer styles - or the history of anything, for that matter - to received narratives that we all can agree on as a gleeful hatchet job from the sidelines, with no aim but the denigration of others' hard work, surely the lowest of possible motives.
I'm sure I'll buy the book sometime and eventually repay the contributors for their presumptive Labor of Love With No Commercial Benefits. But I stand by my original assertion that, based on what I've read, the historical content is dubious.
I stand by my other assertions, too - including that I haven't read it (in its entirety). But I suppose I could try to elide that one.
- 28 October 2011 at 03:18
- Niall said...
"Respect and irreverence," no less, Mr. Brown.
- 28 October 2011 at 03:19
- The Beer Wrangler said...
Although this is a much needed work with much to applaud, a work from OUP should be open to academic peer review. The historical entries should have been reviewed and academically referenced, (as Pete's excellent book on IPA was).
I hope the falling out between Garrett Oliver (a man i greatly respect) and Martyn Cornell will not mean that a second edition will not have Martyn's contribution on his areas of expertise. Alternatively, perhaps Pete would volunteer to write those entries which have come under criticism on British beer styles/history and keep to his great standard of historical research and referencing?
- 7 November 2011 at 22:27
- Pete Brown said...
BW, very fair points - bout the book was peer reviewed, very carefully
- 8 November 2011 at 09:10
- Steve Berke said...
I enjoyed reading your work. I'll come back for more
Keep up the good work :) from TheStillery, a stuart bar in Florida
- 8 November 2016 at 01:16


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from the linked article, this says it all:
"Worldwide media tablet shipments"
shipments != sales
Apple's iPad share of the fondleslab market slipped slightly in the last quarter from 61.5 per cent to 54.6 per cent. But with the demand for tablets booming and Apple selling 15.4 million units in the last quarter of 2011, it's unlikely anyone will shed tears over these results in Cupertino. The 2011 Q4 stats from IDC show a …
from the linked article, this says it all:
"Worldwide media tablet shipments"
shipments != sales
It's a result we all know is coming though, right? Apple's sales, though still growing meteorically, aren't going to keep up with such a rapidly expanding market — especially now Amazon have jumped in.
The interesting thing is going to be whether Amazon's fork of Android ends up deviating so far from the original that it becomes a different market segment again.
Apple doesn't seem to be planning to lose on the iPad.
The iPad 2 is still around for a reason, you can already get a refurb 16Gb unit for $349 and Best Buy was even selling it new for $369 last week.
Want to bet we'll see further reductions along the year? Between a $199 Kindle Fire and a $299 larger and generally nicer iPad what will people pick?
The Kindle Fire is still only on sale in the US, despite the rumours. The iPad is available almost anywhere in the world.
When the Kindle Fire market share stagnates in the US can it really grow much more?
Apple stated the iPad2 would sell for $399. Yet, you "categorically" made your comparison between a $199 Kindle and a $299 "iPad 2".
Please, see the book on the edge of your desk? It's called "reality". Apple hasn't read it yet, so you're not allowed to, either.
They've not finished milking the market for their margins, so would rather sell less than accept $100/less per item. They need that! With only $100,000,000,000 in the bank ($100 billion), and a stock value making them the most valuable in history, they cannot possibly afford to sell iPads for less than $200/profit/each. Kindle, potentially losing $10/each... "does not compute".
Maybe some folks heard a new iPad was coming and waited until this quarter. Context is everything.
I have just ordered mine, delivery April 5th. Yes I did wait to see what the 'new' one was all about.
However, this is not an upgrade purchase.
Exactly what I was thinking. The iPad3 rumors have been swirling for quite a while, and more people have gotten more savvy about Apple's product cycle as time goes on.
For all of you that you dont know, the new iPad 3 or iPad HD is already out
Even with a reduced market share, Apple still has the high end pretty much to itself.
I wonder if the board of Apple ever play Scrooge McDuck and go and swim through oceans of dollar bills in their vaults?
It's an interesting point - much like the smartphone market, it's very likely Apple won't give a flying fig about 'market share' as long as they carry on making a ton of money. They have an ecosystem which is probably big enough now to be self-sustaining for a decade, so while they may make lots of noise about 'killing Android', the reality is they're pretty much insulated from whatever Google might do by an enormously thick layer of money.
I'm surprised ElReg falls so easy for the click bait, as the poster above states and none the less in the very first line of the report.....shipments into sales channels.
I am certain Apple's share is falling, it has to eventually, but let's compare oranges to oranges here.
It's a bit of a stretch to call anything from Kindle an Android Tablet in the truest sense, Android derived certainly. It's been said many times before that you can't really compare a Kindle to an iPad as they're focusing on different markets
We'll have to wait and see what happens in the next couple of quarters. The cheaper iPad2 could swing things quite differently
the winner is....
Sales increased. Market share slipped.
Thus the folly of relying on percentages without understanding the underlying data is shown.
Once Apple has their user base and vendors locked in those cheap apps and 30% subscriptions will start to increase. As a corporation they have to make more money this year then the last one or people start getting fired. This will be done by increasing percentages taken from content providers more than likely.
Their shareholders will also be revolting soon to get a dividend on their stored cash.
In fact I see quite a few parallels to the Roman Empire. Rome was the biggest and baddest power on the planet at one point. Only Apple does not have an equivalent to Hadrian's wall and the barbarians are gathering. That $589 stock price will not last and when it bursts their customers will pay the price. I for one will fiddle while it burns.
You do realise you're categorising Android users as a Barbarian Horde, right?
>Only Apple does not have an equivalent to Hadrian's wall and the barbarians are gathering.
Errr... you're aware that Hadrian's wall was only relevant in the context of the ass-end of the boonies of the Roman empire, right? At the height of Roman power.
The barbarians you are thinking of came several hundred years later, about a thousand miles away and by that time the Romans were kinda gone anyway from Britain anyway and couldna hae cared less about Scotland.
But don't let that get in the way of your entertaining us ;-)
Bullshit research is bullshit.
I'm sure Apple aren't going to complain about having the highest marketshare but ultimately they'd prefer to trade marketshare for margin rather than cutting the cost of their products to compete with their competitors.
Look at the iPhone for example, Apple has been quite happy to let Android overtake the iPhone but they're making money hand over fist due to the high profit margin whereas Android sales are based on high volume rather than high profit margin. Same thing with the Mac too.
Yeah. You are right. Just this morning, as Tim Cook was sipping his breakfast coffee, he was thinking how awesome it would be to give up another 5-10% market share to Android. Not only that, he also decided to drop all the lawsuits against Android manufacturers. Because he realized that you were right: market share doesn't count.
I mean come on now, does what you're saying make any sense to you?
There's not enough information presented in this article to draw any sort of conclusion. Did Apple sell more or fewer units than last quarter? Did the market size change from last quarter to this quarter? Without knowing the trends and the sizes, one can't say anything significant about Apple's future. Perhaps they've sold 10% more units in a market that has increased in size by 50%. Does this spell doom for Apple? I don't think so!
Show us some real information to support the sensationalist headlines.
The reason Apple will continue to dominate is their business model. No matter how good Android is, most Android tablets need to make all the profit on the sale of the device, the most obvious exception is the Kindle Fire where Amazon have an ongoing revenue stream. Samsung et al, do not.
Windows 8 could change that, if M$ get it right, but Android? Where's the money?
the thing that always gets me is how much the picture changes when you stop comparing iOS to android, and start looking at iPads vs Samsung galaxy tabs, motorola zooms, asus transformers, HTC fliers etc etc
Every sale of an iOS tablet device, is an iPad. Every sale of an android device, is one of any of dozens of different devices, and I think this is what Apple knows. They may have a (slightly) dwindling share of the slablet /software/ market, but their position in the hardware market still seems to be pretty strong.
So, Microsoft has spent billions creating a tablet OS, porting to ARM, rewriting Office and seeding bunches of app vendors to port their star products to Windows and IDC predicts they won't be able to even hit 1% market share in three years?
The Samsung series 7 slate is really a publicly released prototype, and yet, with Windows 8 installed, it is by far far more capable and useful than all the other tablets out there. No half assed, half baked apps, it us genuinely a full computer that also has an app mode for when you're out and about.
But maybe that is a good point. Maybe Windows tablets shouldn't be in the same category as iPad and Android as unlike those two, they're useful for something.

subset: commoncrawl


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Nowitzki's return offers Dallas a glimmer of postseason hope
By Rob Mahoney
Although the Mavericks have known success and failures aplenty over the last decade-plus, this season has managed to put all that has transpired in Dallas over that span into the proper context. Even at their lowest, the Mavs were persistently relevant; they ended a Finals series in heartbreak and a dream regular season in embarrassment, but Dirk Nowitzki's growth and the creativity of the front office allowed Dallas to rally year after year to retain playoff form. In some seasons the Mavs were contenders and in others they were merely present, but through it all they were there in the postseason, waiting for the right moment or the right move to put them over the top.
That moment finally came in 2011, but Dallas' title-winning explosion has been followed by a dreary decline into silence. Roster upheaval has given the illusion of progress at times, but no move has been made without a leery eye to the team's finances. NBA franchises should be consistently aware of their financial outlook as it relates to the salary cap and the luxury tax, but all of the Mavs' moves since their first-ever championship have come within the restraints of their own cap-related goals. Mark Cuban and Donnie Nelson saw the catharsis of the title as a chance at a proper rebirth, with visions of Dwight Howard, Chris Paul, or Deron Williams in Mavericks blue. Hindsight isn't kind to the way that gambit played out, but Cuban and Nelson nevertheless chose to risk their team's league-wide significance for the sake of chasing Dallas' next superstar. The result, even after two offseasons of clever moves and value signings, is what you see before you today: a 13-20 Maverick team that's still and soundless, rendered into a pure state of incapability by the months-long absence of Nowitzki.
Dallas is 25th in the league in net rating, which is essentially a representation of margin of victory (or in the Mavs' case, defeat) adjusted for pace. They rank 23rd on offense and 25th on defense, leaving them no sanctuary on either side of the ball. Their strong start has been upended by weeks of misery, to the point that ESPN's Hollinger Playoff Odds calculates that Dallas has just a 0.7 percent chance to even make the postseason cut. Even for a team that has resigned itself to a season of stopgaps on one-year deals, that kind of projection is pretty brutal -- and, if I may say, a bit unfair when viewed absent of the greater potential for improvement.
No one can dispute the Mavs' misery, but it seems that some of the Dallas-related gloom coursing through NBA circles is reliant on all things remaining constant. Without Nowitzki, the Mavs are a bad team. We knew this going in, and knew that a .500 record through Dirk's recovery would represent a huge achievement. But now that Nowitzki is starting to vaguely resemble his former self (he had his best offensive game thus far against the Heat on Wednesday), why wouldn't we expect Dallas to improve dramatically? The Mavs have always been constructed in a way that works outward from Nowitzki, and they rely on him to score points, draw defenders and space the floor. He creates driving lanes and open jumpers for his teammates just by lingering in the right spots, and yet many act as if Dallas' fate has been sealed by the terrible play of a terrible, Nowitzki-less team.
Things will improve, as will that 0.7 percent mark. That isn't to say that Dallas will ultimately make the playoffs (keep in mind that I pegged the Mavs as one of the teams most likely to miss the cut), but to rule them out entirely with Nowitzki only now returning to form seems to fundamentally misunderstand just how important Dirk is to this (and every) Mavericks team.
Production is the mark of a star player, but Nowitzki's structural significance is far greater than the 20-something efficient points he contributes on a nightly basis. Many of Dallas' sets are designed around the threat that Nowitzki creates, and it often uses him as either a decoy or screen-setter to create hesitation on the part of the defense. It was no coincidence that Tyson Chandler regularly had open lanes to roll to the rim, that J.J. Barea's man never recovered off of Dirk in time to prevent dribble penetration, or that Jason Terry was able to use a single screen and a few dribbles to create a good look at a pull-up jumper. Even when Nowitzki wasn't directly contributing to a score, he was always somewhere along the edge of the broadcast view, pulling in a defender or two with the threat of his jumper. Defenses fear Nowitzki, and have little respect for Shawn Marion, Chris Kaman, or Elton Brand from the same range. All are theoretically capable of making some of the same mid-range shots, but none can do so under the same pressure, nor provide the same relief for the rest of the offense.
Replacing Nowitzki's scoring was an issue for Dallas, but a less pressing one than managing the structural void. This is nothing new; replacing Nowitzki's impact when he is absent is something that Dallas has wrestled with for years -- a fact that has only served to exaggerate his on-court import. Without Dirk on the floor this season, the Mavs are outscored by 3.5 points per 100 possessions, which is, as mentioned above, pretty crummy. But the same effect holds true for pretty much every Mavericks team for which such data is available -- including that vaunted 2010-11 squad that won a championship on the basis of its adaptability and depth. During that season, Dallas famously lost seven of nine while Nowitzki sat with injury, and the same basic struggles translated to every minute in which Nowitzki wasn't on the floor. Dallas was outscored by 4.9 points per 100 possessions whenever Nowitzki sat that season, mirroring the struggles Dallas is experiencing this year. Shot creation will always be an issue for this Dirk-dependent outfit whenever he's out of the lineup, regardless of whether his running mates are Jasons Kidd and Terry or Darren Collison and O.J. Mayo.
Speaking of that pair, no two individual Mavericks stand to gain more than those productively inconsistent guards. Both have the potential to fill key roles for a good offensive team, but are clearly reliant on high-level talent to help disguise some of their more pronounced weaknesses. Ball security has been a recurring problem for Dallas all season, and neither Collison nor Mayo have been particularly judicious in their work off the dribble. That's made it difficult for both players to access the most helpful facets of their respective games (speed and sweet shooting), and entire Mavericks' possessions are often wasted due to the guards' utterly flappable ball-handling. Nowitzki won't run night clinics to work on Collison's and Mayo's ball skills, but his addition to the pick-and-roll will help to pacify defenders who had otherwise ignored Brand, Kaman and Brandan Wright to rush the ball. There's a reason why offensive functions are nominally clustered as a "system" -- everything is related, and removing Nowitzki from the equation drastically alters the nature of a given possession.
Dallas has been so strapped for scoring that Rick Carlisle could scantly afford to play Elton Brand -- Dallas' top defensive big by far -- for heavy minutes. Age and injury began taxing Brand years ago, but the last two seasons have been particularly brutal in terms of his plummeting scoring output. Such is the case when a mid-range specialist finally sees his most potent offensive skill leave him. Brand still converts his intermediate looks at roughly a 39-percent clip, but that percentage is a far cry from the first-rate marks that once made him a 20-point scorer. His manageable 15.6 points per 36 minutes last season has slipped to just 11.2 points over that same interval this year, and in Nowitzki's absence it made some sense for Carlisle to limit Brand's playing time (21 minutes per game) in order to bank on Kaman's interior scoring and a variety of small-ball, pace-pushing lineups.
Yet with Dirk back, the need to run so small becomes less glaring, and Brand becomes an altogether more useful player. Brand doesn't have the height or speed that empower most of the top interior defenders, but he brings an Andrew Bogut-style savvy to his defensive positioning that allows him to get the most out of his limited athletic resources. His dance through the paint is really more of a plod, but he hits all the right steps along the way -- the hedge, the recovery and the challenge are all executed in step and in time. All that's left to find is a more suitable dance partner, and Kaman can't quite keep up. Nowitzki himself may only be solid on that end when playing at his best, but his overall offensive influence should allow Carlisle to use Brand more frequently, giving Dallas the most balanced frontcourt pairing possible and a shot at redeeming one of the league's most porous defenses.
Even in an optimal unraveling of all of these strategic lines, Dallas is still set to be a rotten rebounding team and no better than average on either end of the court. But two-way mediocrity may well be enough in a Western Conference field that's good but hardly perfect. There's no question that the West's playoff race is down to standing room only, but Dallas is still only four games back of the eighth seed after a tough stretch of schedule and the absence of an absolutely crucial player. They'll need to make up ground quickly, but there are plenty of weaknesses to exploit in the playoff-contending teams overhead. Portland has enjoyed a particularly friendly slate thus far and awaits the fallout from having one of the worst benches in the entire league. Minnesota has been fun to watch all season, but the reintegration of Kevin Love hasn't quite gone as expected, and the Wolves have been splitting games all season. Utah is just 3-7 over its last 10 games, hardly more promising than the 2-8 record that Dallas has returned over that same stretch.
Those factors alone don't get the Mavs back into the postseason picture, especially when Dallas needs to get the best of four higher-ranked teams from this point forward in order to keep their 12-year playoff streak alive. But ultimately, Nowitzki gives Dallas a chance. He isn't yet close to the height of his powers (it was just a few games ago that he was shying away from late-game possessions, and Dirk's defense thus far has been horrid), but the Mavs will improve incrementally as he retraces his steps. And that gives Dallas a chance to extend its historic streak and grasp at a relevance that it ultimately forfeited two summers ago.Statistical support for this post provided by NBA.com.


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Topic: Side Effects of Gem/Cis
I'm just wondering if anyone has had the side effects I've had with Gem/cis. I've had 6 treatments then took a three week break and went to Florida. I have my 7th treatment tomorrow. Florida trip was very difficult for me. It was cold in Florida and my stomach swelled so bad that I practically stopped eating for comfort. I was drained five days before I left for Florida but the fluid came back quickly. I got drained again yesterday, 1/28 and the doctor is planning on putting a drain in where I can drain myself as the fluid builds up. That should be planned within the next two weeks.
I've discovered that air travel is not good for me - maybe travel at all is out. That's a bit depressing but at least I tried it.
My biggest side effect is the swelling of my feet and legs. My legs swell all the way up to my thighs. The swelling is so bad that clothes don't fit me. My legs are so tight I can barely bend at the knees. I am doing lymphedema therapy and they're talking about wrapping my legs to help with the swelling. I go for that appt tomorrow prior to my chemo treatment.
The good news is that my CT scan on 1/7 showed 10% shrinkage of my tumors so I guess the Gem/Cis is working. But yesterday I had blood work before the stomach drainage and some of my liver levels went up so I'm worried about that. My bilirubin is still within normal range but it went from 0.4 to 0.6. Makes me think the tumors are growing. Also, my alkaline phosphatase went from the 400's to the 800's so that's scary. I have a metal stent in the bile duct in my
liver since May 2013 and so far it has worked great.
Just wondering if anyone else has the feet/leg swelling issue with this chemo? And also if fluid build up in the stomach is worse because of the chemo or totally from my disease? I'm getting tired of treatment and am starting to think about stopping everything and see what happens. I had hoped the trip to Florida would have strengthened me but it actually exhausted me.
Any advice would be appreciated. Also, if anyone has the drain for fluid and can tell me how they handle it, I would appreciate it.
Peace to all.
Love & Hugs,


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Don't bet the house on the advance of an Internet sales tax measure. In fact, don't bet on the House, either.
The Senate-approved measure aimed at helping states capture an estimated $23 billion in annual sales taxes from Internet and other transactions is facing a steep challenge in the House of Representatives.
The Senate vote in favor of the Marketplace Fairness Act was by a margin of 69 to 27.
Boehner not a fan
House Speaker John Boehner is expressing caution. In an interview with Bloomberg TV, Boehner was asked whether he would support a measure enabling states to collect sales taxes on out-of-state "remote" sales. "Probably not," Boehner answered. As a basis of his skepticism, the Ohio Republican said the patchwork of sales tax rates across the country would be too difficult for businesses to manage. In reaction, the leading retail industry trade group remains optimistic. "The process in the House will provide an opportunity to address any outstanding concerns. We look forward to that debate in the House," said Stephen Schatz, spokesman with the National Retail Federation.
Giving it a hearing
The House Judiciary Committee plans to begin looking into the matter. The panel led by Rep. Bob Goodlatte, R-Va., has not yet scheduled a hearing. Supporters look to remedy 1992 Supreme Court ruling Quill Corp. v. North Dakota. The court held that a business must have a physical presence in a particular state if required to collect sales taxes from customers in that state. The justices also held open the possibility that Congress could seek to provide a solution through legislation, which is what supporters of the bill were hoping to do.
Most retailers like it
While Boehner's concern involves feared challenges collecting the taxes, retailers support the legislation. The Retail Federation complains the status quo favors online retailers at the expense of their brick-and-mortar competitors. Retailers are also concerned about the modern phenomenon of "showrooming," where someone checks out an item in a store and then orders it from an online retailer. Retailers with less than $1 million in annual sales would be exempt from the legislation.
Amazon.com supports the legislation as well, saying that the $1 million exemption covers 99 percent of online sellers.
Overstock.com wants another fix
Jonathan Johnson, a senior executive with Overstock.com, said his company is "opposed to the specific legislation, but we're not necessarily opposed to the concept." Johnson added, "We think a federal solution to the patchwork of varying state laws about remote seller tax collection would be a good thing."
He says that, as hearings are held in the House, "the flaws of the bill will come out and could be fixed."
EBay's bid
Pioneering online auction site eBay is waving a red flag. It has sought to increase the exemption to sellers with $10 million or less in annual sales or 50 or fewer employees. Brian Bieron, senior director of global public policy for eBay Inc., said, "We believe small businesses should be protected from any new national-scale tax collection scheme." Asked about the claim that all but 1 percent of online sellers would be exempt, Bieron said, "That's like lumping in all the garage sales in America." eBay's seller base includes everyone from so-called casual sellers to large retailers like Toys R Us and Dick's Sporting Goods.
At Overstock, Johnson said if eBay's solution of exempting larger sellers were allowed, that could encourage the existing patchwork, creating even bigger potential headaches for smaller operators.
Usual anti-tax crowd
While the legislation proposed seeks to collect taxes already levied, well-known forces opposing new taxes are aligned against these bills as well. Those include the conservative Heritage Foundation and Americans for Tax Reform, founded by Grover Norquist. While some supporters of the legislation are invoking the notion of states' rights, that may not be enough to overcome the "no new taxes" mantra.
Follow me on Twitter @hamrickisms.


text:
An Observational Study of Cholesterol in Coronary Arteries (COLOR)
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: January 27, 2009
Last updated: June 8, 2017
Last verified: June 2017
|Tracking Information
|First Received Date ICMJE
|January 27, 2009
|Last Updated Date
|June 8, 2017
|Actual Start Date ICMJE
|February 2009
|Primary Completion Date
|February 2016 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Identify associations of LCP with angiographic or symptomatic presentation of coronary artery disease in a catheterization laboratory population [ Time Frame: after completion of the study - during data analysis ]
|Original Primary Outcome Measures ICMJE
|Not Provided
|Change History
|Complete list of historical versions of study NCT00831116 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Identification of associations that LCP or the Lipid Core Burden Index (LCBI) may have with atherosclerosis appearance, progression, regression, and/or cardiac event [ Time Frame: Upto 2 years post procedure(baseline) ]
|Original Secondary Outcome Measures ICMJE
|Not Provided
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|An Observational Study of Cholesterol in Coronary Arteries
|Official Title ICMJE
|Chemometric Observation of Lipid Core Plaques of Interest in Native Coronary Arteries Registry
|Brief Summary
|In April 2008, a coronary catheter based imaging system, LipiScan, was cleared by the FDA for use in detecting lipid core containing containing plaques of interest (LCP). These plaques are rich in cholesterol. The way that cholesterol and other lipids deposit with the coronary artery is unique to each patient. This study is an organized attempt to observe the LCP and the variety of ways that it presents in patients as detected by this recently approved device. This information will be used for physician training and to observe the behavior of the LCP in response to no therapy and currently approved therapies. The purpose of this project is further medical knowledge of the LCP and its treatment.
|Detailed Description
|Not Provided
|Study Type ICMJE
|Study Design ICMJE
|Observational Model: Cohort
Time Perspective: Prospective
|Target Follow-Up Duration
|Not Provided
|Not Provided
|Sampling Method
|Non-Probability Sample
|Study Population
|Subjects will be recruited from those presenting or referred to the cardiac catheterization laboratory for elective cardiac catheterization.
|Condition ICMJE
|Intervention ICMJE
|Device: Intravascular Near Infrared Spectroscopy
Intravascular imaging with a catheter based spectroscopy system.
Other Name: LipiScan Coronary Imaging System
|Study Groups/Cohorts
Subjects who have at least one native coronary artery imaged with the LipiScan CIS.
Intervention: Device: Intravascular Near Infrared Spectroscopy
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Enrollment ICMJE
|Completion Date
|April 2017
|Primary Completion Date
|February 2016 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Study Sponsor ICMJE
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|PRS Account
|Verification Date
|June 2017
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
Skip to content
Key resources
Aboriginal Drug and Alcohol Council (SA)
Aboriginal Drug and Alcohol Council (SA)
This flipchart has been developed to explain to people who may be thinking about getting pregnant, or who are pregnant, about the dangers of drinking alcohol when pregnant and the risks of fetal alcohol spectrum disorder (FASD). It has been designed especially for Aboriginal drug and alcohol workers and Health Workers and their clients.
Topics included in the flipchart include:
Australian Indigenous HealthInfoNet abstract
This resource would be useful to use in a one-on-one consultation with clients.
Aboriginal Drug and Alcohol Council (SA)
155 Holbrooks Road
Underdale SA 5032
Ph: (08) 8351 9031
Fax: (08) 8352 4546
Report broken link


text:
I got my 4s long after it was released but recall that getting my iP4 was a bit rough via apple.com. I ended up using AT&T's website. I recall also though that those who ordered via apple.com got there's delivered the day before everyone else.
Now I'm confuddled. I'll try apple first, AT&T if that fails. No one in my house sleeps tonight until I have an iP5!
I'm not willing to take that chance, lol.
I've been checking the website every hour just in case. Got to wait till 3 am!
Does the Apple store accept debit cards or only credit cards? And can you order multiple iphones?
Never a good idea to use debit card on the interwebz.
^^^ waits for credit card to be maxed out with phones and other junk lol
Do you think verizon's site will still have them available at 5:30-6 am? I'd prefer to wake up 30 minutes before I normally do than 3 hours
What if your trying to switch carriers? Can you order for the carrier your tryin to switch too or do you have to stay with the original carrier? I'm on Att and trying to switch to Verizon.
Am I in the minority waiting for reviews and a jailbreak on iOS 6?


text:
Sign into our member site to view your information online.Forget your username or password? Not registered? Register here
amiloride (generic name)
Midamor (brand name)
It helps you make more urine and to lose excess water from your body
(a MIL oh ride)
Table of Contents
Top Learning Centers(Recursos en Español)
What is this medicine?AMILORIDE (a MIL oh ride) is a diuretic. It helps you make more urine and to lose excess water from your body. This medicine is used in combination with other medicines to treat high blood pressure or congestive heart failure.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
How should I use this medicine?Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take with food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
What should I watch for while using this medicine?Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor what your blood pressure should be, and when you should contact them.
You may need to be on a special diet while taking this medicine. Ask your doctor. Also, ask how many glasses of fluid you need to drink a day. You must not get dehydrated.
You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.
What side effects may I notice from receiving this medicine?Side effects that you should report to your doctor or health care professional as soon as possible:
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Where should I keep my medicine?Keep out of the reach of children.
Store at room temperature below 30 degrees C (86 degrees F). Protect from moisture, freezing and excessive heat. Throw away any unused medicine after the expiration date.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


text:
THERE'S a new law force on the mean streets of Witney.
Town ranger Jim Casson will be reporting problem issues like graffiti, litter and drugs.
The Witney town councillor even carries a police radio to summon the law.
Mr Casson, 59, who lives on Witney High Street, has been in the role for more than five weeks. He said: "On Sunday morning at Witney Lakes I went down and it looked like there had been one of those raves.
"There were beer bottles everywhere and little metal cannisters, which someone later explained to me were for taking gas.
"I wondered why there were so many balloons around."
Mr Casson formerly managed a corporate guest house on Oxford's Banbury Road for scientific publisher Elsevier.
He said of his new role: "It's something I'm very much enjoying so far."
- Our top stories:


text:
Such a Deal!Math brain teasers require computations to solve.
A man received an ad in the mail that promised to double his money. For every dollar he sent in, the ad guaranteed to return double his money minus a $24 service charge. He thought that was a pretty good deal, so he sent in his money. In the return mail he received double his money less the $24 service charge. He returned the money he had made and again it was doubled less the service charge. But, when he sent in the money a third time, he was charged the $24 service fee, but received no money back. How much money did the man lose?
HintWork backwards.
AnswerHe lost $21. Work backwards. If his last payment was doubled, less $24, it must have been $12. Payment two must have been $18, and payment one $21.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
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text:
In KC, Romeo is out, Pioli stays.
At the Dumpster Fire known as the Jet's, Tannenbaun is gone and Rex stays?
Adam Schefter @AdamSchefter
Jets announced they fired GM Mike Tannenbaun and are keeping HC Rex Ryan.
The House has been cleaned in Cleveland; bye bye Weeden:
Adam Schefter @AdamSchefter
Browns general manager Tom Heckert and head coach Pat Shurmur have been fired.
Arizona next?
Adam Schefter @AdamSchefter
Cardinals coach Ken Whisenhunt is scheduled to meet Monday with team president Michael Bidwill.


text:
A Backdoor Play on the Herbalife Story
Pretty much everyone has heard both sides of the Herbalife (HLF) story by now. Massive short selling preceded one of the most orchestrated and documented attacks on corporate legitimacy in market history.
Herbalife shares had been stellar performers until last March when they peaked at $73. The stock collapsed to $24.24 recently before rebounding to close at $39.16 on Thursday. A Cayman Island headquarters and about 80% non-U.S. sales certainly make the reported figures suspect....276 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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text:
This summer, 37 New York-based fashion designers embarked on a fashion journey when they were selected to participate in Design Entrepreneurs NYC, a free "mini-mba" program that was developed by FIT and the NYCEDC and now in its second year.
Their curriculum was intensive and comprehensive. Designers were required to take three weekend seminar classes that focused on everything from marketing, operations and financials from industry professionals. Designer Richard Chai spoke to the group about his fashion track and the realities he faced in the business while growing his brand. They also had access to FIT resources and could take additional courses such as Excel for fashion designers, costing, social media and presentation tips.
The program paired each designer with a mentor to help them work through their business plan and support them along the way.
It culminated with a showcase and pitch night where 16 pre-seleceted designers had the opportunity to present their business plans to a panel of senior executives to get feedback and share their strategy for growth. The group was narrowed down to four brands including: Kai D, a Brooklyn-based menswear label and Kallio, a sustainable childrenswear company. At the end of the evening, Becca McCharen of Chromat, an architecturally inspired swimwear line which also creates caged pieces that have been worn by Beyonce, Nicki Minaj and Madonna was awarded with a check for $25,000, a contribution given by G-III Apparel Group.
Vasumathi Soundararajan, an FIT alumni and the Chief Underwearist of a menswear label called Ken Wroy, which is an anagram of New York received the second-place prize of $10,000 also from G-IIII.


text:
Burnley youngster Cameron Dummigan has signed his first professional contract at Turf Moor penning a two-year deal.
The right back was on target for the Clarets in their 3-2 Under 21 Premier League Cup semi final defeat to Manchester City on Tuesday night.
The Northern Ireland under 19 international, 17, has been a key player in the Clarets' development squad this season.
Burnley boss Sean Dyche said: "We are delighted to sign Cameron on a first senior deal.
"He is one of a number of young players on their career pathway and we look forward to working with him over the coming years."
The deal is subject to FA clearance.


text:
The U.S. Department of Agriculture has re-imposed employment restrictions on Celso Paganini after the dismissal of a suit Paganini filed in the U.S. District Court for the Southern District of New York.
The case was dismissed in December 2012.
The USDA previously found Paganini responsibly connected after Paganini Produce LLC failed to pay an $83,290 award to a California receiver, a violation of the Perishable Agricultural Commodities Act.
Paganini Foods LLC, Swedesboro, N.J., and Celso Paganini are now restricted from operating in the produce industry.


text: Michael Muhney's (Adam, Y&R) Internet remarks have raised the ire of his soapster dad, Eric Braeden (Victor). While Genoa City was mourning Victor's presumed demise, Muhney tweeted: "The fact that basically every resident of Genoa City believes Victor is dead for the 148th time is insulting to the actors & the audience." In response, Braeden huffed back via Twitter: "4 an actor who has been on Y&R a mere 3yrs to suggest the present storyline involving a 30yr veteran is "insulting" is delusional arrogance."


text:
Kitzhaber appoints new head of Ore. National Guard
SALEM, Ore. (AP) Gov. John Kitzhaber has appointed a new head of the Oregon National Guard.
Kitzhaber said Wednesday that Brigadier General Daniel Hokanson we be the next adjutant general.
Hokanson is a 1986 graduate from the U.S. Military Academy and served on active duty before joining the Oregon National Guard. He has served in Iraq and Afghanistan and commanded nearly 100 air-rescue and firefighting missions throughout the Pacific Northwest.
Hokanson is currently the director of strategic plans and policy for the National Guard Bureau at the Pentagon.


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If you will be in the vicinity of the White House or the National Geographic museum this summer, you may want to take a walk over to Farragut Square Park. This park is manicured and kept clean by DC's parks and recreation staff throughout the year. During the week you will find Washingtonians sitting on a bench during their lunch breaks enjoying the sunshine or chatting with a colleague. Saturday mornings Batala drumming troupe practices for their upcoming performances, and this is so much fun to watch. The highlight of the summer in this area are the free summer concerts held from June to July on Wednesdays from 5:30pm to 7:30pm. The music is always rhythmic and fun. I urge you to enjoy the district as the locals do!
Farragut Square is serviced by both the Farragut North Metro station (red line) and the Farragut West metro station (blue and orange line). There are also several bus routes with stops adjacent to the park. Please visit metro's website for travel options.
Alexis, Innkeeper
American Guest House Bed and Breakfast
Washington DC Bed and Breakfast accommodations. We are centrally located, 10 minutes walk to DuPont Circle metro/subway, 1 mile north west of White House.


text:
NEW loan winger Steve de Ridder says Wanderers belong at the highest level alongside his parent club Southampton – not at the wrong end of the Championship where they currently lie.
The Belgium international made his debut from the bench at Watford on Saturday, just 36 hours after sealing a one-month deal at the Reebok.
And while he knew about the club before his switch north, the 25-year-old admits he was not fully appreciative of the facilities and set-up at Wanderers.
He admits his surprise at the Whites' current position at the wrong end of the second tier.
De Ridder said: "My first impression is unbelievable. I can't believe this club is in the Championship because it's quite huge.
"I know, because I come from a Premier League club and this set-up is unbelievable. This club belongs at the highest level. I watch the football news as well, so I know about Bolton.
"A few of the lads at Southampton have told me about Chris Eagles, so I knew what kind of qualities a few of the lads have.
"When I knew I was coming to Bolton I read up on a few.
"I am surprised, definitely, with the position but, to be fair, it's not unusual to see clubs like Wolves and Birmingham around us in the table. It is hard because it is a different type of football from the Premier League in the Championship.
"I hope we can start adapting."
De Ridder's brief cameo at Watford will, he hopes, be the first of several outings back at a level he enjoyed success at last season.
While he only has seven Saints appearances to his name this campaign, he played in 37 matches last season as Southampton secured promotion as Championship runners-up.
He wants to get back playing regualrly and believes a club like Wanderers can give him that opportunity.
He said: "When I am here I just want to make the best of it. I am not thinking about Southampton.
"I want to perform here and the rest will come.
"I did make a few appearances at the end down there, I was doing well, and I think I had come on in five out of the last six games.
"I know what level it is and I will try to be important here and not think about the rest.
"Obviously games are what I want, but also wins and trying to be a part of the club to get us a bit higher in the table.
"It was good to play some minutes (at Watford) and make my debut, but obviously the result did not go our way, so it's off to next week."
De Ridder's switch late on deadline day took many Wanderers fans by surprise but the former Belgium youth international said he knew of the interest and was keen to make the move.
He added: "It was quite last minute, to be fair.
"I knew Dougie Freedman was after me for a long time but Southampton didn't let me go for a while.
"In the end, I pushed it a bit because I needed more minutes.
"It was 10pm on deadline day when it all went through, so I am a happy man to be here.
"There were a few options but once Bolton became involved, I wanted to come here."


text:
China is on its way up, way up.
There "are unmistakable warning signs," writes John Hickman in Foreign Policy, "that China may surpass the United States and Russia to become the world's preeminent spacefaring power."
The U.S. shuttle program ended in 2011. But China is planning to launch a "space lab" in 2015 and have its own space station by 2020, the same year that the International Space Station is set to be scrapped.
An excerpt from the print edition of This Just In for Aug. 6, 2013. This Just In appears in the A-section of the Tribune-Review on Tuesday and Friday.


text:
If you want to skip the photos below and watch a video instead, here is a video of how to make this recipe. See more recipe videos on My You Tube Channel.
We made this in the Crock-Pot Casserole Crock Slow Cooker which was really perfect for this recipe, but any oval-shaped large slow cooker will work.
4 lb. orange-fleshed sweet potatoes (4 large or 5 medium sweet potatoes, often called yams or sweet yams in U.S. stores)
2-3 T olive oil, divided
non-stick spray for crockpot
1 T sweet potato spice mix, divided (see below)
fresh ground black pepper to taste
sea salt to taste (I used a sea salt grinder)
2-3 T butter to add to the top of the sweet potatoes (optional, use more or less to taste)
Sweet Potato Spice Mix:
(Grind the herbs together with a mortar and pestle or spice grinder, then mix in the salt.)
2 T ground coriander
1 T ground fennel
1 T dried oregano
1 T Aleppo Pepper (or use a smaller amount of cayenne pepper)
2 T kosher salt
Spray inside of slow cooker with non-stick spray or olive oil. Put sweet potatoes in crockpot, spreading them out in a single layer as much as you can, and dot ing with a little butter if desired. Cook on high, stirring a couple of times and pouring off any water that accumulates under the lid.
Sweet potatoes are done when they're completely softened and fragrant, about 3 hours. Mash slightly if desired, and season to taste with fresh ground black pepper and sea salt. At this point you can brown the sweet potatoes a little in a pre-heated 450F/220C oven for 15-20 minutes. We did think that gave good results, but it's totally optional. Serve hot, dotted with a little more butter if desired.
Make Ahead Tips:
Sweet potatoes can be cut and mixed with olive oil and seasoning earlier in the day. Cooked sweet potatoes could be kept in the crockpot on low or warm for a few hours if needed.
Low-Carb Diet / Low-Glycemic Diet / South Beach Diet Suggestions:
Find More Recipes Like This One:
Nutritional Information?
More Holiday-Worthy and Healthy Recipes for Sweet Potatoes:
Sweet Potato Gratin with Goat Cheese and Parmesan ~ Kalyn's Kitchen
Lentil and Goat Cheese Stuffed Sweet Potatoes ~ A Couple Cooks
Roasted Sweet Potatoes and Mushrooms with Thyme ~ Kalyn's Kitchen
Coconut-Spiced Sweet Potato Casserole ~ Jeanette's Healthy Living
Sweet Potato Appetizer Bites with Feta and Green Onion ~ Kalyn's Kitchen


text:
A 22-year-man has died in a car crash near Liddington.
The incident happened at 23.17pm last night.
The man, who was with four other men all in their early 20s, was driving a black Renault Clio along the B4192. They were travelling towards towards Swindon from the Aldbourne direction.
The driver, who was from Swindon, and a rear passenger were trapped in the vehicle and had to be freed. Breceived serious injures and were taken to Great Western Hospital by ambulance.
A short time later the driver died from his injuries.
The seriously injured passenger was later taken to Frenchay Hospital, in Bristol. The other occupants of the car managed to get out and other suffered relatively minor injuries.
Friends of the occupants were also travelling on the road at the same time in a silver Vauxhall Vectra.
The 27-year-old driver of this vehicle was arrested on suspicion of causing death by dangerous driving, but has been released on police bail without charge.
Officers would like to speak to anyone who was travelling on the road at this time and may have seen either of the vehicles.
Call PC Kevin Fry on 101 extension 7203111 or Sgt Barrie Card on 101 extension 7203113.
Alternatively you can email email@example.com, firstname.lastname@example.com or call Crimestoppers on 0800 555 111.


text:
ASCO Annual Meeting
June 3, 2013
Women with higher-risk, early-stage breast cancer who received weekly chemotherapy with paclitaxel (Taxol) after surgery as part of a clinical trial lived for the same amount of time without the cancer returning as those who received higher doses of the same drug every two weeks (known as dose-dense therapy). However, the researchers found that the women who received chemotherapy every week experienced fewer and less serious treatment-related side effects.
Chemotherapy is the use of drugs to kill cancer cells, which work by stopping the cancer cells' ability to grow and divide. Drugs like paclitaxel are often given after surgery for breast cancer to kill any cancer cells that may remain in the body. Paclitaxel is usually given to patients either weekly or every two weeks, at a higher dose. Although doctors currently use both treatment schedules, this is the first time researchers have looked at whether they have different results for patients.
To answer this question, more than 2,700 women with node-positive (cancer was found in the lymph nodes at diagnosis) or high-risk node-negative breast cancer that could be removed surgically first received treatment with one of three different schedules of two common chemotherapies, doxorubicin (Adriamycin) and cyclophosphamide (Neosar), and then received either a standard dose of paclitaxel every week for 12 weeks (12 treatments) or a higher dose every two weeks for 12 weeks (six treatments).
The researchers observed that the cancer in 82% of the women who received weekly chemotherapy and 81% of women who received chemotherapy every two weeks had not returned within five years. However, the women who received treatment every two weeks experienced more allergic reactions and greater muscle and bone pain compared with those who received treatment every week. Receiving treatment every two weeks also caused more neurologic toxicity, a common side effect involving numbness, tingling, and pain in the fingers and toes. This side effect potentially could be lessened or reduced by giving only four treatments as is the current practice rather than the six treatments that were given as part of this study.
What this means for patients
"Our results suggest that either treatment plan will have a good effect, but the weekly schedule seems to result in better quality of life for patients, causing less muscle and bone pain and allergic reactions," said lead study author G. Thomas Budd, MD, a medical oncologist at the Cleveland Clinic in Ohio. "The findings provide assurance that women can choose the lower-dose therapy without sacrificing their chances of survival." After a diagnosis of cancer, patients and their families must make a number of decisions about cancer treatment, some of which are more difficult than others. Take time to learn about your treatment options and be sure to ask questions about anything that is unclear.
Questions to Ask Your Doctor
- What type of chemotherapy do you recommend? Why?
- How often will I need to have treatment? For how long?
- How will the treatment be given?
- How will chemotherapy affect my daily life? Will I be able to work, exercise, and perform my usual activities?
- What are the potential side effects of this treatment? What can be done to prevent or manage these side effects?
For More Information


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text:
A Compassionate Use Study of Tenofovir Disoproxil Fumarate as Treatment for HIV Infection
This study has been completed.
Gilead Sciences
Information provided by:
NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov Identifier:
First received: January 24, 2000
Last updated: June 23, 2005
Last verified: May 2000
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This study allows patients who need a new anti-HIV treatment to take tenofovir disoproxil fumarate (tenofovir DF), an experimental drug. This study also looks at any side effects the drug causes.
|HIV Infections
|Drug: Tenofovir disoproxil fumarate
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|An Open-Label, Multicenter, Compassionate Access Study of the Safety of Tenofovir Disoproxil Fumarate Administered in Combination With Other Antiretroviral Agents for the Treatment of HIV-1 Infected Patients
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Formic acid Tenofovir Tenofovir Disoproxil FumarateU.S. FDA Resources
Further study details as provided by NIH AIDS Clinical Trials Information Service:
|Estimated Enrollment:
|Study Start Date:
|December 1999
HIV-1-infected patients who are currently receiving stable antiretroviral therapy add tenofovir DF to their regimen. Study participation lasts for approximately 48 weeks. Interested patients should contact their physicians.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
You may be eligible for this study if you:
- Are HIV-positive.
- Have a viral load greater than or equal to 10,000 copies/ml.
- Have a CD4 count less than or equal to 50 cells/mm3, or have a CD4 count greater than 50 and no more than 200 cells/mm3 with an opportunistic (AIDS-related) infection within 90 days of study entry. (Patients with a CD4 count above 200 cells/mm3 may be considered depending on drug supply.)
- Are at least 18 years old.
- Agree to use barrier methods of birth control (such as condoms) while on the study and for 30 days afterward.
- Have a life expectancy of at least one year.
Exclusion Criteria
You will not be eligible for this study if you:
- Have a history of a serious kidney or bone disease.
- Have severe nausea, vomiting, or trouble taking medications by mouth.
- Are pregnant or breast-feeding.
- Abuse alcohol or other substances that your doctor thinks would interfere with taking this medicine.
- Are taking any medicines that interfere with kidney functions.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002453
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002453
|United States, California
|Tenofovir Coordinating Center
|Foster City, California, United States, 94404
Sponsors and Collaborators
Gilead Sciences
More Information
Keywords provided by NIH AIDS Clinical Trials Information Service:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00002453 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 24, 2000
|Last Updated:
|June 23, 2005
Keywords provided by NIH AIDS Clinical Trials Information Service:
Drug Therapy, Combination
Disease Progression
Anti-HIV Agents
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
ClinicalTrials.gov processed this record on September 21, 2017


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Please check Product Description and images before purchase.
Mens Poste Walton Black Snake Chukka Boot Size 8
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Ex display. This item is the last pair we have in stock at present. However we may list this style again in future dependant on store and online returns.
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- Shop Soiled
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We have provided an image of the exact shoe you are purchasing (if there is more than one defect we have provided an image of each) and a brief description of the defect. Please take this into account when purchasing.
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text:
Glorious sunshine brought families to annual Amberley Cow Hunt
1:10pm Monday 5th May 2014
By Sarah Yates
1:10pm Monday 5th May 2014
By Sarah Yates
GLORIOUS sunshine brought crowds to hunt down dozens of colourful cows around Amberley at the weekend to help raise funds for livestock in Africa and the school.
Families of Amberley decorated 33 weird and wonderful cows as the bank holiday weekend saw the return of Amberley Parochial School's annual Cow Hunt, celebrating the forthcoming arrival of the real ones.
The wooden cows were dotted around the village, Minchinhampton Common and the surrounding parish as families arrived to start the hunt, on both Saturday and Sunday afternoon.
Over 1,000 maps were sold with a turnout of around 3,500 people to the picturesque village.
Visitor's made sure the vintage tea tent worked flat out selling homemade cake and teas all weekend.
Face painting and other activities were underway alongside a Cow Hunt quiz.
Quiz sheets and trail maps were sold and funds raised will go to help the school buy outside play equipment, as well as Send a Cow which provides livestock for families in Africa.
Deborah Kakoz, chair of the cow hunt committee said: "We were over the moon to have another sunny weekend for our Cow Hunt and so thrilled with the amount of local support and folk enjoying the trail and the teas.
"It was a huge team effort and great fun."
The real cows will be released back onto Rodborough and Minchinhampton Commons later this month.
© Copyright 2001-2017 Newsquest Media Group


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WFUV's The Big Broadcast Turns 40, 1/6
On Sunday, January 6 between 8 PM-12 midnight The Big Broadcast celebrates forty years on WFUV (90.7 FM/wfuv.org). Host Rich Conaty will mark the occasion by airing excerpts of an historic interview with Connie Boswell of the Boswell Sisters which hasn't been heard since 1974.
The Big Broadcast was born almost by accident. On Sunday, December 31, 1972, the last of the three "official" hosts of WFUV's In the Mood failed to arrive by 11 PM, leaving an eighteen year old Fordham freshman in charge of the one hour program. "When nobody showed up the next week," says Rich Conaty, "I renamed the show The Big Broadcast and locked the door to the studio, in case any of those guys tried to get back in!"
The focus of the program, 1920s and 30s pop and jazz, hasn't changed since the 1970s, but it has expanded to four hours, drawing from a growing library of 40,000 CDs, LPs and original 78 RPM recordings.
"We're enormously proud of Rich," said WFUV General Manager Chuck Singleton. "His encyclopedic knowledge of that musical era - and his unbridled enthusiasm for it - have earned him of all ages, from senior citizens to young hipsters."
Throughout its 40th Anniversary year, The Big Broadcast will also revisit conversations with such music makers as Cotton Club star Cab Calloway and "The Street Singer," Arthur Tracy, both of whom appeared in the 1932 film, The Big Broadcast, "Star Dust" lyricist Mitchell Parish, and Edward Eliscu, who wrote the words to the 1929 song, "Great Day," which has closed The Big Broadcast for 2050+ Sundays.
Although the original artists have gone, The Big Broadcast has been enriched recently by visits from Wall Street Journal columnist, Will Friedwald, band leader Vince Giordano, who appears on HBO's Boardwalk Empire, and Michael Feinstein, who included Conaty in his PBS series, Michael Feinstein's American Songbook.


text: Interest high for speech on economy By George Hohmann September 22, 2012 Story Share CHARLESTON, W.Va. -- Jeffrey Lacker's scheduled visit to Charleston in November promises to be especially newsy.Lacker is president of the Federal Reserve Bank of Richmond, which serves most of West Virginia plus the District of Columbia, Maryland, North and South Carolina and Virginia. He is scheduled to present the outlook for the U.S. economy at this year's West Virginia Economic Outlook Conference, Nov. 15 at the Charleston Civic Center.Two factors make Lacker's views on the economy especially notable:This year he is a voting member of the 12-member Federal Open Market Committee, the committee within the Federal Reserve System that sets monetary policy by making decisions about interest rates and the U.S. money supply.Lacker has become the committee's lone dissenter.The latest example of this came Sept. 13. The FOMC, faced with ongoing high unemployment and a sluggish economy, voted to buy $40 billion of mortgage-backed securities every month until the job market improves. The committee didn't set a limit on how much would be bought or the duration of the purchases. The committee did say it would keep short-term interest rates low through mid-2015. The vote was 11-1."I dissented because I opposed additional asset purchases at this time," Lacker said in a Sept. 15 prepared statement. "Further monetary stimulus now is unlikely to result in a discernible improvement in growth, but if it does, it's also likely to cause an unwanted increase in inflation."Lacker went on to say that improvement in labor market conditions "appears to have been held back by real impediments that are beyond the capacity of monetary policy to offset. In such circumstances, further monetary stimulus runs the risk of raising inflation in a way that threatens the stability of inflation expectations."In a speech Sept. 17, Lacker said impediments include the decline in the housing market and the shift in economic activity away from residential construction and related supply industries."The collapse in housing construction was a huge blow to our economy, and it will take a substantial amount of time for us to recover by shifting labor, capital and spending toward other growth opportunities," he said.He also cited political gridlock "that has delayed remedies to our unsustainable federal fiscal path" and created "paralyzing uncertainty." The gridlock "appears to have seriously dampened investments and hiring for the new business ventures that typically would take up the economic slack caused by one sector's decline," he said.In addition, Lacker said he dissented because he disagrees with the open-ended time period of the Fed's planned purchases and the decision to buy more mortgage-backed securities. Such purchases "distort investment allocations and raise interest rates for other borrowers," he said. "Channeling the flow of credit to particular economic sectors is an inappropriate role for the Federal Reserve." Lacker wrapped up his Sept. 17 speech by saying he has the utmost respect for his colleagues on the FOMC and he hopes they're correct that the additional stimulus won't raise the risk of destabilizing inflation.Reach George Hohmann at firstname.lastname@example.com or 304-348-4836. Story Share Story Share Trending Now 1 Police seek car driven by woman found dead in Kanawha River 2 Teen pleads guilty to involuntary manslaughter in Oakes Field shooting 3 Facebook founder visits Cabin Creek Health Systems 4 Man allegedly cuts father in Rand over argument about a sandwich 5 Toyota announces new $115 million project for WV plant Cracking codes for court Previous Story The making of a dwarf (photo) Next Story


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This week's MCV is now available to view online – and it features Disney vs Activision as the battle for video game toys begins.
We also analyse the challenges faced by HMV, THQ and Play.com and run our exclusive 2012 retail charts.
We've listed the contents in full below.
Download our iPad app now, which includes access to the last two years of MCV back issues.
You can also read the magazine in your browser. Click here to subscribe or click here to access this week's individual issue.
Individual issues cost £1.99. You can subscribe for three months (iPad only - £19.99), six months (£34.99) or 1 year (£64.99).
In this week's issue:
- Toys go to war as Disney takes on Skylanders
- DETAILED: HMV's two year battle for survival
- All the charts, publisher rankings and best selling consoles of 2012
- UK accessories market grows 12% in 2012
- We analyse the spate of Android games consoles
- Microsoft's new cloud studio and what it says about the future of Xbox
- We discuss what went wrong at online retailer Play.com
- OPINION: THQ's risk taking ought to be applauded not condemned
- Plus! Previews of Aliens Colonial Marines and Scribblenauts, another interview with a member of GAME's staff plus our new-look Off The Record.