text:
- Description
- View Full Specifications
- Year:
- 2008
- Length:
- 49'
- Engine/Fuel Type:
- Twin / diesel
- Located In:
- St. Maarten/St. Martin
- Hull Material:
- Fiberglass
- 38346-2634131
- Current Price:
This Privilege 495 truly lives up to the definition of a "bristol" yacht. It is absolutely in pristine condition. The owners sail this yacht in the Antilles and have a dedicated full-time caretaker to look after the boat when it is back in its home port. All systems are maintained at precise manufacturer intervals and the hull gelcoats, brightwork, engine rooms, interior, dinghy are polished and "manicured" year round.
This is the sought-after owner version with a large king-size bed in the forward "beam-to-beam" cabin and two guest cabins aft. The galley is up and includes dishwasher and ice maker. The interior is fitted in a light beechwood veneer that is finished to a high gloss. This was the last 495 built at the Privilege yard. It is the culmination of years of refinement and upgrades on this model. The owner, who has owned other bluewater cats, monohulls and powerboats specified the boat to meet the challenges of the rigorous Caribbean conditions.
The yacht has seen limited use and registers just under 1000 hours on the engines. All comfort amenities are aboard: large ONAN generator, full air conditioning, watermaker, dishwasher. The deck is layed out for short-handed sailing with electric primary winches and electric genoa furler. The hard-top bimini facilitates mainsail access and handling.
A superb yacht, one of the finest we have ever seen. Please contact Alexis de Boucaud to arrange a viewing with our broker in Saint Martin.
Contact - Alexis de Boucaud
The Multihull Company Florida Office
Located at the Ft. Lauderdale Marine Center
250 SE 2nd St. #1530
Ft. Lauderdale, FL 33315
Phone: 484-744-2740
E-Mail: email@example.com
Please contact Alexis de Boucaud
350 2nd Street#1530
at 484-744-2740 Fax: +1 954 200 6150
Additional Specs, Equipment and Information:
Builder: Privilege
Designer: Mark Lombard
LOA: 49 ft 1 in
Beam: 24 ft 1 in
LWL: 46 ft 1 in
Minimum Draft: 4 ft 4 in
Displacement: 11300 kgs
Total Power: 55 HP
Engine 1:
Engine Brand: Volvo
Engine/Fuel Type: Diesel
Location: Starboard
Engine Hours: 1000
Drive Type: Sail drive
Engine 2:
Engine Brand: Volvo
Engine Type: Inboard
Engine/Fuel Type: Diesel
Location: Port
Engine Hours: 1000
Drive Type: Sail drive
Engine Power: 55 HP
Fresh Water Tanks: (570 Liters)
Fuel Tanks: (680 Liters)
Number of cabins: 3
Number of heads: 3
Three double cabin owner Prestige version with galley-up:
- Master stateroom forward with king-size bed accessible from both hulls and ensuite master bathroom including electric toilet, wash basin and large walk-in shower
- 2 guest cabins aft in each hull with queen-sized beds and en-suite bathrooms with shower, wash basin and toilet
- 1 single crew berth, stbd hallway
- Interior in beechwood veneers, glossy varnished
- Marine plywood floors with "teak and holly" stripes
- Curtains and blinds troughout
- Mosquito screens
- L-shaped Alcantara covered seating for 8 pax with large dining table
- Huge storage under salon seating
- Special sliding cabinet for dishes
- Sliding bar unit
- Lounge area
- Courtesy lights throughout the boat
- Full air conditioning: CLIMMA 4 x 16,000 BTU compressors
- Wine cellar
- Galley up on port side
- Double stainless steell sink
- 3 burner stove
- Oven
- Microwave
- Ice maker
- Built-in waste bin
- 51 gl / 12V stainless steel refrigerator with foam insulation
- 14.5 gl / 12V stainless steel freezer with foam insulation
Sails and rig
- INCIDENCES full-batten mainsail, Hydranet cloth, 860 sqft, 2008
- INCIDENCES genoa, 565 sqft, 2008
- INCIDENCES gennaker, 807 sqft, 2008
- MARECHAL mast, 64'8 white-lacquered light alloy, with 8/9 rigging
- HARKEN ball-bearing-mounted mainsail luff slides
- 1 pair of spreaders with leather protectors
- 1 set of navigation lights, anchor light, deck spot
- 1 mechanical windvane
- 3 steps on mast
- 23' white-lacquered aluminum boom
- Lazy jacks and lazy bag
Deck Equipment
- Electric windlass with up and down foot switches
Primary anchor: 44 lb DELTA with 246' of chain
Secondary anchor: 44 lb BRITANNY with 82' of chain & 164' grapnel line
Spare FORTRESS anchor with chain and rode
Mooring bridle
Emergency tiller
Stainless steel plate anchor chain protection
- Stainless steel mooring cleat
- 2 x electric primary winches for genoa/gennaker sheets and main halyard on coach roof
- Electric winch on port coach roof for genoa furling line
- Manuel winch for mainsail traveler
- Winch handles & handle box
- Cockpit covered by a rigid hard-top bimini with 4 lights and sliding hatch
- Custom cockpit cushions
- Bimini curtains for all sides with windows
- GRP cockpit table with banquette seat; spare teak cockpit table
- Mainsheet track with car, 2 end-stops & blocks
- Jammers for mainsail car line/mainsheet tackle
- Genoa tracks with cars, blocks, end-stops, and jammers on coach roof
- Gennaker deck fittings with bow sprit and PROFURL furling drum
- PROFURL Genoa furler
- Helm console, with engine controls, instrument panel & compass, windlass remote control and double helm
- Leather-covered aluminium steering wheel
- White lacquered aluminum davits
- Gas cylinder locker
- Numerous lockers under seating for rope, emergency anchor and miscellaneous equipment
- 3 deep cockpit lockers containing liferaft, divign gear and misc.
- Large sail locker forward with deck hatch
- Forepeak lockers with deck hatches
- Trampolines and s/steel bow pulpits with teak seat and navigation lights
- Bow fitting with double fairlead
- 3 row Lifelines
- Openings in guardrail on port and starboard sides.
- Handrails on coach roof
- S/steel anti-chafing plates for warps
RAYMARINE E80 chartplotter
RAYMARINE multifunction display
RAYMARINE 240 VHF base and second station units
1 x RD424 4KW HD radar radome scanner
Remote control Smartcontroller fo autopilot
Connection for laptop
AIS pack with antenna MAT129 and connection serie E
4 charts XL RAYMARINE (Caribbean)
Entertainment unit : AM/FM radio receiver / CD MP3 player with 2 speakers in saloon and cockpit
- RAYMARINE E125 tactile chartplotter
- RAYMARINE ST 60 repeaters: speed/log, depth, wind
- Autopilot RAYMARINE ST7001 with gyro S3G
Electrical Equipment
- 220V AC, 12V DC electricla circuits
- ONAN 7.5 KVA, 220V generator
- MASTERVOLT 100 A charger and 12V DC - 220V AC invertor
- VICTRON isolating Transformer 3600 W 125/230
- Galvanic Isolator 50/60 A
- 30A SUNSAVER Solar Regulator
- 220V AC shore power chord
- DESSALATOR 100l/hour watermaker; operates on 220V and 12V
- 14 foot AB alu-RIB dinghy and 15 HP YAMAHA outboard, new March 2013
- WINSLOW liferaft, 6 pax
- Full safety equipment
The Company offers the details of this vessel in good faith but cannot guarantee or warrant the accuracy of this information nor warrant the condition of the vessel. A buyer should instruct his agents, or his surveyors, to investigate such details as the buyer desires validated. This vessel is offered subject to prior sale, price change, or withdrawal without notice.
Visit Website


text:
Spruce Up the Sight Word: Can
Sight words can be hard for beginning readers to learn, but this little printable is sure to help them along the way. Coloring and decorating the word "can" helps kids engage the word in a hands-on way so it's sure to stick in their memory. Place her finished word art on the refrigerator where she'll see it everyday, and she'll have it learned without even trying!
Check out the entire series for more sight word decorating.

subset: commoncrawl


text: Millions of years in the making, tanzanite gemstones are relatively new to the gemstone-loving world. They were discovered in 1967 in Tanzania and instantly prized for their mesmerizing hues and color-changing effect. Tanzanite gems are deeply rich in color. When treated with heat and cut, tanzanite displays two colors: sapphire blue and deep purple. These colors alternate depending on the viewing angle and lighting conditions. Tanzanite is December's birthstone, making tanzanite jewelry an amazing way to celebrate a December birthday.


text:
'…Milbury hasn't shown much haste to bring the former Buffalo Sabres coach in. Bartlett hopes Milbury will consider Nolan over the usual names that are churned out for coaching vacancies. "You can't find the next Scotty Bowman," Bartlett said, "if you keep going back to the same old boy network." The concern for Nolan isn't his ability to coach. It's his detachment from the NHL since he left the Sabres in 1997.'
You are here: Home / SabresBeat / Islanders Still Looking But Nolan's Out of View


text:
'Creature of habit' Headley back in rhythm
SAN DIEGO -- For Chase Headley, baseball has always been a rhythm game.
The Padres third baseman is at his best when he's in the lineup every night, fulfilling his daily routine and getting as many reps as possible in the cages.
So, it's not surprising that Headley struggled a bit coming off a fractured left thumb tip that held him out of action for the final two weeks of Spring Training and the first two weeks of the regular season. When that rhythm returned, Headley quickly reverted back to his 2012 form.
"You have your select few natural guys who wake up out of bed and can come put the barrel on the baseball each and every day without thinking about it," Headley said. "Unfortunately, I'm not one of those guys. It takes me some time, it takes me some repetition to get me where I want to be. But hopefully once I get there, I can sustain it."
Headley has hit in 10 straight games entering Monday, marking the fifth time in his career he has posted a double-digit hitting streak. He has raised his average from .160 all the way to .286 during that time.
"That's why you get Spring Training -- so you can have some at-bats going into the season," Headley said. "Unfortunately, I had mine cut short. I missed four weeks, so I was basically starting over at square one."
Headley sustained the injury March 17 during Spring Training, and returned exactly one month later. From there, he had four hits in his first 25 at-bats, but has since hit .368 with five doubles, two homers and six RBIs during the hitting streak.
"Most players are creatures of habit," Padres manager Bud Black said. "There's structure to their day and there's structure to their daily routine. Chase is one of those guys."
AJ Cassavell is a reporter for MLB.com. Follow him on Twitter @ajcassavell. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Who said exercise has to make you all sweaty and stinky? Not me! In fact, I'm thinking today's steal, the Fiskars Squeeze and Lever Punches, might just become the next hot fitness trend. Let's face it, we busy ladies like to multitask! So why not combine crafting with strength training, even if it is just those forearms getting an itty-bitty workout? Your projects will also be transformed into something sleek and sexy with one of these amazing punches, so it's a total win!
I had so much fun working with the punches today that I couldn't settle on one particular sketch design. However, I don't want to leave you all longing so I created this week's sketch based off my favorite card this week.
I love how easily the banner squeeze punch works. It's honestly kind of like slicing through room temperature butter! So much for building those muscles, but hoorah for building cute cards!
Of course the banners were calling to be used again...
...and again!
Then I made a couple of cards using the Jenni Bowlin Grandma's Doily punch. It works great to create a window border.
Or to add a simple splash.
Gotta love a card that packs a punch! :)
The cards that have been popping up on our Facebook page this week have been amazing! I particularly loved this card by Charissa Miller.
Just in case you didn't know we love to give away free scrappy swag to those of you that participate in our Monday Card Madness sketches.
If you'd like to enter to win our September Monday Card Madness swag package:
- Create any or all of the weekly Monday Card Madness sketches.
- Post the card to our Facebook fan page, or any other online location.
- Leave a comment on one of the Monday Card Madness blog posts with a link to your card no later than 11:59 pm, MST on Friday, September 28th.
Have fun creating cards this week!


text:
PONTE VEDRA BEACH, Fla. - A fishing boat that the Coast Guard believed sank in the Gulf of Mexico in December washed onto Ponte Vedra Beach on Sunday.
Two fishermen were rescued from a life raft hours after they abandoned the "Lucky Dog," which began taking on water more than 170 miles off the coast of Madeira Beach -- south of St. Petersburg -- on Dec. 28.
The 33-foot boat was presumed lost. Its owner, Curly Egan, told a Fort Myers television station at the time, "It ain't lucky. ... Damn thing tried to kill me."
But the boat apparently also had more life in it.
SLIDESHOW: 'Lucky Dog' now grounded on PVB
Ponte Vedra Beach homeowner Pam Harrington, who reported the boat was grounded on the beach behind her home. The boat apparently was carried by the loop current around the tip of Florida to the East Coast, where it washed ashore overnight.
"If boats could talk, it would probably have an interesting story," Harrington said.
Ponte Vedra Beach resident Chuck Herklotz said he's seen wreckage on the beach before, but nothing this big.
"I don't know whether it's going to go back out again or come in closer with the next high tide, but it looks like it's sunk where it is right now."
The Coast Guard says the boat's captain is responsible for removing the boat from the beach.
"Everyone is just curious as to where it came from, and how it got here," Harrington said. "But more importantly, how's it going to leave."
The Coast Guard said it has removed the fuel from the boat and has contacted the owner, who was surprised to hear the vessel had washed up on the East Coast. The Coast Guard said the owner seemed responsive to salvage the vessel.
Copyright 2012 by News4Jax.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
CHICO — Erik Lyon is clearly a believer that if at first you don't succeed, try again, and has launched his second campaign to win a seat on the Chico Unified School District board of trustees.
In 2010 Lyon entered the race for the board with a "slate" of two other candidates, deeply disturbed about what they felt were errors on the part of the existing board when it came to dealing with a serious budget crisis.
This time he is running on his own and with a dramatically changed opinion of the performance of the board.
In a meeting with the Chico Enterprise-Record editorial board, Lyon said the current board did a "fantastic job" with the budget, but there are other problems he believes need to be addressed.
He alleged there are kids having sex on school campuses, and there are gangs and violence issues parents would find alarming.
Lyon said there needs to be severe consequences for anybody engaging in these kinds of behavior.
While he says he sees the problem, Lyon doesn't claim to have the answers.
"I don't have any really great solutions on the top of my head. I have really tried to avoid coming up with a lot of lofty solutions."
He said he tried to offer solutions the last time he ran and it "kind of came back on me."
Lyon explained his primary motivation for running for the school board are his three daughters, one is already in Chico schools, a toddler and a newborn.
He said people should vote for him because he'll work as hard as he can for his daughters.
He said he is running as an average community member and rejects any hint he has special deep knowledge about the nuts and bolts of what the problems might be or how to repair them.
"This time I admit it. I'm ignorant."
"I can't know what is going on" until he is on the board, he explained.
He described what he will need to know is like an iceberg, with only a small percentage of the information visible on the surface.
Lyon said his daughter provided him one bit of information he will be taking to the board.
He said when his oldest daughter began school she was excited about the prospect of eating hot lunches in the cafeteria. Lyon said that changed when she tasted the food. He said his daughter claims the school food tastes so bad she refuses to eat it.
Lyon, who is a licensed chid and family counselor, claimed that makes him worry about students who depend on school breakfasts and lunches for two-thirds of their daily meals. He said he wonders if those kids go through the day hungry because they won't eat the school meals.
At the same time he said, "I love the Chico school district. We have a really stellar school district here. The community is fabulous and the schools are fabulous."
Staff writer Roger H. Aylworth can be reached at 896-7762, email@example.com, or on Twitter @RogerAylworth.


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text:
BOYNTON BEACH, Fla. - Police have made an arrest after a local movie theater was forced to evacuate because of a bomb threat.
Boynton Beach Police evacuated movie-goers and workers from the Cinemark Theaters on North Congress Ave. on Sunday night after a clerk said she received a hand-written note that there was a bomb in the business.
During the investigation, theater clerk Chrislaine Jean Louis, 17, told police an unknown man had given her a movie ticket receipt with the threat on the back of the receipt.
Detectives said the threat read exactly: "I have a bomb and 5 gun on me plan 1) kill everyone and me."
Police emptied the theater but could not find any threat.
They then reviewed theater surveillance tapes to see if they could find the man the clerk was talking about. They found no one matching his description.
Detectives then re-interviewed Jean Louis and said she confessed to writing the note.
She was arrested and charged with making a threat to discharge a destructive device. Jean Louis was then taken to the Palm Beach County Juvenile Assessment Center.
No motive for the threat was revealed.
Copyright 2012 by Post Newsweek. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
LEESBURG, Fla. - Police have arrested a 51-year-old Leesburg man who they say downloaded the largest collection of child pornography ever found in Florida.
John Shearen, who investigators are calling the "most notorious child porn downloader they've taken into custody," was arrested around 9 a.m. Thursday and charged with 15 counts of possession of child pornography and 15 counts of distribution of child pornography.
When investigators searched Shearen's Wild Harbor Lane apartment, they discovered he had downloaded up to 1 million images and full-length videos of child porn on multiple computers and mass media storage devices, investigators said.
Shearen admitted to his crimes, police say, and other charges may be pending. He was booked into Lake County Jail on a no-bond status.
At his first court appearance, which was held Friday morning, Shearen appeared antsy and was shaking while keeping his head down.
A judge, who maintained the no-bond status, appointed a public defender to represent Shearen, who will be prosecuted by the State Attorney 5th Judicial Circuit.
Watch Local 6 for more on this story.
Copyright 2013 by ClickOrlando.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Friday January 7, 2005 10:07 pm
Holographic Storage
Posted by Categories: PC / Laptop
Does the sound of a 1.6TB (yes, that's terabyte) drive excite you? Me too. Inphase Technologies has developed a method of storing data called Holographic Storage. In essence, this method allows data to be stored on the entire depth of the disk, rather than just the surface. The drives are slated to be released in 2006 in sizes ranging from 200GB to 1.6TB.
Read More | Web Pro News
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text:
Celebrating his 50th Grand Prix race at the Circuit de Barcelona-Cataluñya, for the Spanish Grand Prix, Lotus F1® Team driver, Romain Grosjean claimed vital first season points which had previously eluded the Lotus F1® Team. A superb, yet taut qualifying saw the Frenchman begin from P5, the highest grand prix start of the season, whereas stablemate Pastor Maldonado kept his head up, disappointed at having to start from the back of the pack in P22, thanks to a run-off in Q1.
During the 66-laps of the race however, both drivers delivered for the team. Romain held onto his P5 slot for as long as possible keeping his adversaries in his rear view. Power unit issues mid-race however meant he slipped from P5 but still maintained a top ten position to finally take the flag in P8. Pastor on the other hand was consistently climbing but unfortunately got slapped early on with a 5-second stop/go penalty. Never-the-less he recovered quickly to advance some 7 places, coming home in P15.
Romain Grosjean P8 E22-03: "It's been a tough battle for us to get points this season and that was certainly one of the hardest races I've contested in a long time. I did everything I could to drive around the power unit issues, which really made things difficult when battling the other cars. It's good for all the crew at the track and at Enstone to finally get a reward for all their hard work. There are still a lot of areas where we can improve and certainly the car wasn't as quick today as it was yesterday, with the different track conditions as well as the other issue. It's Mothers' Day in Switzerland so this one's for my mum!"
Pastor Maldonado P15 E22-01: "We made a step forward in terms of pace with the car this weekend, it was much more competitive than 15th but the lack of top speed meant we weren't able to attack even if we had a quicker car than others around us. We need to keep working on that and to be faster on the straights. Today's result is a bit disappointing but my race had been already compromised by starting at the back the grid. At least we saw the chequered flag and collected more data for the team to keep on developing the car."
Frederico Gastaldi, Deputy Team Principal: "We are very pleased for the team and for Romain to have scored our first points today. It's certainly been a long road to get to this place. It's not all a sweet taste as we were expecting to have finished further up the grid. We had some issues with the power unit again so we need to keep working with Renault Sport F1 to ensure we can keep fighting for as many points as possible. We have two days of testing coming up and our target is to carry on making improvements in performance and reliability."
Now as we continue into the European leg of the season, the team prepare for the following round of the competition that takes place in Monaco on the 25th May 2014.


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Thanks for the well wishes guys. Here's to hoping.....
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Thanks for the well wishes guys. Here's to hoping.....
Sometimes it even happens to us too.
My wife (a writer) was told 3 weeks ago that her division of publications was bought out by another publishing company and she would be laid off.
The catch was that the new company would be back the next day to begin talking to them about their ideas and the potential for working in their company.
Turned out she was re-hired by the new company at the same salary, much better benefits, double the vacation days, was given the option to work at home in a home office they would furnish (desk, computer, phone line, fax, etc.) which was surprising since we figured she would have to quit if she wouldn't move to the California-based publisher.
So she was laid off, got 2 weeks severance, vacation pay, started working for the new company right away, at home, and it's a better and more famous publisher with way better perks and benefits.
Getting laid off was her lucky day, it turned out.
Hope it works out half as well for your wife.
It's rare. Yesterday I had a solid poop. That was good.
Thanks PT. I'm confident she'll find something pretty quick, although now they are talking like there's a slight possibility that they could reorganize her into another department thats safe....So who knows. Guess we'll take it day by day.
Kind of like how Twes is supposed to take his meds but never does?
lol, yeah sorta like that.....
I'd rather be in a treestand right now.
Just so you know.
You could both come crashing down.
I hate it when that happens.
The weather is absolutely perfect....wish I had somewhere to go flyfishing.
Ever notice how friendly folks are at a shootin' range??.
Old pickup, weld in some seats in back, deep sea fishing tackle, a cooler with a case, get some buddies, head to the 'burbs, and you're dog-fishin', brother.
But then, I'm a dorkfish.
Ever notice how friendly folks are at a shootin' range??.
Humpf...nobody around. Must explain why the trees are bent over like there's a hurricane.
Ever notice how friendly folks are at a shootin' range??.
I wish I was in a tree.
I will be tomorrow.
There are just so many things going on this time of year.
Why do all the good things in life have to happen all at once in the fall?
Weather . . . deer hunting . . . duck/goose hunting . . . college football . . . NFL football . . . the anniversary of my birth . . . leaves turning colors.
That's just off the top of my head. You'd think they'd spread it out some. Jeez.
It's like there is nothing, nothing , nothing nothing..EVERYTHING... next thing you know you are spit out in February not knowing what hit you.
Which is fine as long as I have deer at the taxidermist from the season. Last years should be done soon.
Have a great weekend.
Last edited by Twes; 10-03-2008 at 04:22 PM.
Yep you just nailed it. February sucks.
Good luck in the tree this weekend. We demand pictures if you succeed.
I haven't been seeing the quality deer this year that I saw last here here at home but there is a 9 pointer I'd like to kill even if he doesn't score.
I'd like to have 2 at the taxidermist from the Wisconsin and Kansas hunts but we'll see what happens.
I'll post a pic of last years Iowa buck if I can figure out how to do it.
So - anybody get one?
The poster formerly known as Rimfire
OK...who do I mooch the summer sausage and brats off of?
Santa knows if you lie.
Ever notice how friendly folks are at a shootin' range??.
I didn't see much. Unless you count legions of boone and crocket mosquitos.
Early season you hunt food sources. I think deer hit my beans in the middle of the night.
Sitting hours in a treestand I have a lot of time to think.
Most of us have one of these truck/car key auto lock/unlock buttons with some sort of panic button for the alarm.
I hate these things because I set it off accidently just having it in my pocket.
Why couldn't there be a sliding panel that covers the panic button so it can't be accidently pressed but easily opened so that one can shut the alarm off if need be.
Pretty simple but I think that's a great idea. I'd even spend money for an aftermarket case that I could snap around Fords case that would allow me this funtionality. There's a free idea.
watch it.....Ford may steal the idea. NO NO NO!! NO free ideas...make em PAY!!
According to the movie they offered the inventor of intermittent wipers $30M...yours should be worth at least 500K.
Ever notice how friendly folks are at a shootin' range??.
An incompetent bank agent is doing his upmost to screw my deal.
He will never again see one of my clients.
Ever notice how friendly folks are at a shootin' range??.
I was told to come here and seek life advice from the "experts."
I would have posted sooner, but it was hard for me to figure out how to compose a post without a number in it.


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Started this discussion. Last reply by Tom DelConte Jun 13, 2014. 3 Replies 0 Likes
Hello everyone! I'm looking for a window company, preferably in the SE, that has been really successful in the EE market. One of our partner contractors is looking to shadow people outside of their…Continue
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Scientists project global warming will bring more uncertainty, potentially causing both more extremely dry periods and more heavy rainfall events. These extreme weather events will exacerbate the problems we face with water management and protection in the U.S.
Despite the relative rarity of droughts in the second half of the 20th century, historic records show that regular droughts are more typical for the Southeast. Global warming suggests more is yet to come--continued climate changes will potentially cause both more extremely dry periods and more heavy rainfall events. And, sea level rise could contaminate critical underground freshwater reserves.
More Variable and Uncertain Water Supply: Global Warming's Wake-Up Call for the Southeastern United States
The Southeast should take the following actions to plan for increasing variability in water supply:
Rapidly expanding population, irrigation and power generation have increased water demands.


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Please help me out with any info you might know about this basket. It measures about 7" tall and it feels very old. I received this basket along with all the other I have posted from my father's estate. Thanks a bunch and all comments are appreciated!


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Investors, business leaders, corporate relocation services and Colorado farmers rely on Richard Wobbekind to give them accurate economic forecasts each December. This year, BankOne and the University of Colorado at Boulder College of Business and Administration are formally thanking him.
Wobbekind, director of the Business Research Division at the College of Business and Administration at the University of Colorado at Boulder, is the recipient of the 1997 BankOne Colorado Corporation Faculty Community Service Award.
One full-time faculty member from each CU campus who provides exceptional educational, humanitarian, civic or other service in his or her community is presented with a $2,500 award. Wobbekind will be honored by colleagues and business leaders at a reception on June 10 at the College of Business.
Wobbekind is responsible for the annual Colorado Economic Outlook forum. He relies on the expertise of more than 75 business, government and educational leaders when making employment and economic forecasts. Wobbekind presents his findings to a large public audience in Denver each December and also hosts forums around the state.


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Preposterous Proportions
Which ONE of the following statements is FALSE?
a) Half of FIVE is FOUR.
b) A third of TWENTY is EIGHT.
c) A quarter of NINE is ONE.
d) A fifth of SIXTY-FOUR is NINE.
Fill in the blank below to make the following statement TRUE, consistent with the approach/pattern above (i.e. the common sense answer of "FOUR" is incorrect):
A third of TWELVE is __________.
HintThis doesn't work with the equivalent numbers: 5, 20, 9, and 64, nor with 12 for the bonus.
Answerb) A third of TWENTY is EIGHT.
What makes the other statements true is that, in each case, the ("is") number stated as being the given proportion of the object ("of") number is referring to the Roman numeral(s) that is/are contained within the object number.
Changing the "extra" characters to lowercase letters for the purpose of clarity, we have:
a) "fIVe" ==> Consists of 4 characters, 2 or "half" of which are "IV" = the Roman numerals for "FOUR".
c) "nIne" ==> Consists of 4 characters, 1 or "a quarter" of which is "I" = the Roman numeral for "ONE".
d) "sIXty-four" ==> Consists of 10 characters, 2 or "a fifth" of which is "IX" = the Roman numerals for "NINE".
Statement b) is false because in no way do "VIII" = the Roman numerals for "EIGHT" make up "a third" of "TWENTY" which consists of 6 characters.
And for the bonus, the answer is:
A third of TWELVE is FIFTY-FIVE.
"tweLVe" ==> Consists of 6 characters, 2 or "a third" of which are "LV" = the Roman numerals for "FIFTY-FIVE" ((L=50) + (V=5) = 55).
What Next?
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The R-C Morning Report for Feb. 13
February 14, 2014
The restaurant and health inspections return to The R-C starting with Friday's edition. Carson City has taken over the inspections from the state and will be sending them to us regularly. Our plan is to publish them on page 5 with other news of record.
The Partnership for Community Resources is having its general meeting at 8 a.m. today at its offices on 1517 Church St. in Gardnerville. For more information call 782-8611 or visti their web page at http://partnership-resource.org
The Douglas County Historical Society is hosting Dr. Gene Hattori tonight at the Carson Valley Museum & Cultural Center. Hattori is the curator of Anthropology at the Nevada State Museum and will be talking about the petroglyphs at Winnemucca Lake. The lecture starts at 7 p.m. and is $3 for nonmembers.
A high wind watch returns to Western Nevada on Saturday. In the meantime expect somewhat cloudy skies with a chance of rain in the morning. High could get up into the 60s, with southwest winds 10-15 mph.


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Use of Labeled Glucose to Study Lymphocyte Replication and Survival in HIV-Infected Patients
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- Disclaimer
- How to Read a Study Record
This study will examine how quickly white blood cells called CD4 lymphocytes replicate (divide) and how long they live in both HIV-infected and non-infected people by measuring how quickly the genetic material (DNA) of cells is replicated. To do this, participants will receive infusions of glucose, a non-radioactive form of a type of sugar. Cells normally use glucose to make various products needed for cell growth and replication, including cell DNA. Measuring how much glucose cells incorporate into their DNA can provide important information about cell replication. This rate of incorporation will be examined and compared in HIV-infected people and in healthy, normal volunteers.
HIV-infected patients and non-infected healthy volunteers 18 years of age and older may be eligible for this study. Candidates will be screened with a medical history, physical examination, chest X-ray, electrocardiogram (EKG) and blood tests.
Participants will be given a continuous infusion of glucose at a dose of up to 60 grams (about 2 ounces) per day for up to 5 days. The glucose will be delivered through a catheter (thin plastic tube) placed in an arm vein. Blood samples will be collected as often as daily in the first week following the infusion and then from twice a week to once a month for up to 4 years. Alternatively, patients may undergo leukapheresis a procedure for collecting quantities of lymphocytes up to 10 times during the first month after the infusion, and possibly later as well, but no more often than once every 2 weeks. For this procedure, whole blood is collected through a needle in an arm vein. The blood circulates through a machine that separates it into its components. The white cells are removed and the rest of the blood is returned to the body either through the same needle or through a second needle in the other arm. Participants may be asked to receive up to four glucose infusions. There will be at least a 2-week interval between infusions. Participants who have more than three leukapheresis procedures within 3 weeks will have at least 6 weeks between infusions.
Participants will be followed periodically in the outpatient clinic for evaluation and tests.
This study may provide a better understanding of how HIV causes disease and progressive weakening of the immune system and how therapies affect immunity.
|HIV Infection Immunologic Deficiency Syndrome
|Study Type:
|Study Design:
|Time Perspective: Prospective
|Official Title:
|Studies of Lymphocyte Kinetics Using Stable Isotopes
|Estimated Enrollment:
|Study Start Date:
|September 18, 1997
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
18 years or older.
Able to provide informed consent and willing to comply with study requirements and clinic policies.
Negative urine pregnancy test (for women of childbearing potential).
Hemoglobin greater than 10 mg/dl.
Adequate venous access in the arms for blood drawing and 5 day infusions, and lymphapheresis
Willingness to allow stored samples to be used for future studies of HIV infection and/or immunological function, and willingness to have HLA typing performed. (For previously enrolled patients, patients would be requested, but not required, to provide permission to use stored samples in the future, and to permit HLA testing
Documented HIV infection (ELISA/Western blot positive or, for acute seroconverters, PCR positive).
Negative ELISA/Western blot.
Diabetes mellitus requiring drug therapy.
Active substance abuse or prior history of substance abuse which may interfere with protocol compliance.
Psychiatric illness or disturbance which, in the assessment of the protocol team, may affect patient safety or compliance.
Significant underlying cardiac, pulmonary, renal, gastrointestinal, rheumatologic or CNS disease as detectable on routine history, physical exam, or screening laboratory studies. Patients would be excluded if they had an acute or chronic underlying medical problem that in the judgment of the principal investigator could be exacerbated by participating in the protocol or that would make it difficult for them to comply with the protocol requirements.
Pregnancy or breast-feeding.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001651
|Contact: Cheryl L. Chairez
|(301) 496-3840
|Contact: Joseph A Kovacs, M.D.
|(301) 496-9907
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 email@example.com
|Principal Investigator:
|Joseph A Kovacs, M.D.
|National Institutes of Health Clinical Center (CC)
Additional Information:
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|NCT00001651 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 3, 1999
|Last Updated:
|July 13, 2017
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ):
CD4 Cells
Additional relevant MeSH terms:
HIV Infections
Immunologic Deficiency Syndromes
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Immune System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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BRAVE 'soles' are being invited to walk across broken glass to raise cash for Blackburn Youth Zone's Teen Leaders appeal The £6million Youth Zone, in Jubilee Street, hopes 100 people will walk over 15 feet of broken glass in a stunt also known as 'ice walking'.
Organisers lay out hundreds of broken and sterilised bottles which participants then walk across. Money raised will go towards the Teen Leaders appeal, run in partnership with the Lancashire Telegraph.
We want to raise £60,000 to help train 100 young leaders who will earn vital qualifications while also improving the local community. Events manager at the Youth Zone, Laura Jones, has urged people to get involved.
She said: "Without the success of events such as the glasswalk, we would not be able to invest in keeping our vital services afloat. By taking part in this event, people will be contributing to ensuring that our young people can play a pivotal role in a brighter future for our area.
"We'd be delighted to welcome spectators to come and support the glasswalkers and are looking forward to as many people as possible being in the crowd to cheer on the brave souls."
The glasswalk, on March 5, has been organised by Firewalk UK. Owner Scott Bell said: "We are really looking forward to hosting the event at Blackburn Youth Zone. The idea of walking on razor-sharp broken glass is very scary to most people.
"However, once they understand the principles behind it, they relax with the knowledge that we have taken thousands of people across the broken glass all without an injury."
A training session will take place prior to the glass walk, which is open to anybody over the age of 16. A £30 registration fee will secure a place, and a minimum sponsorship target of £100 must also be pledged.
To register, or find out more, call Laura Jones on 01254 292000, or email laura.jones@ blackburnyz.org.


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Did anyone bet money on the playoffs? I won $100 this year.
We made brackets of the playoff teams and made a point system for each round. I had the Eagles and Patriots in the Super Bowl. The other people involved in the bet both had the Colts winning it all.


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Olivia L. McLean Appointed Office of Emergency Management Coordinator
June 30, 2008
News Highlights
- Olivia L. McLean was formerly the director of emergency and security management for the South Florida Water Management District in West Palm Beach, Fla.
McLean's start date is Aug. 25.
More Information
The Fairfax County Board of Supervisors appointed Olivia L. McLean as coordinator of the Office of Emergency Management (OEM). She will begin her new position on Aug. 25.
Since 1993, McLean has been the director of emergency and security management for the South Florida Water Management District in West Palm Beach, Fla. In that capacity, she led the agency's preparedness response and recovery to all emergencies and disasters through interdepartmental response teams.
Prior to that position, McLean served as the director of the Department of Administration and Risk Management for the City of Boynton Beach, Fla., from 1987-1993; as the assistant to the city manager for the City of LaPorte, Texas, from 1984-1986; and as the special assistant to the mayor in the City of Pasedena, Texas, from 1982-1984.
McLean is a certified emergency manager, which is the highest professional certification offered by the International Emergency Management Association. She is a graduate of the University of Southern Mississippi and holds a master's degree in public administration from the University of Houston Clear Lake and a certificate in leadership in crisis from Harvard University.
McLean will receive an annual salary of $131,000.
OEM provides emergency mitigation, preparedness, response and recovery services to the residents of Fairfax County by writing the Emergency Operations Plan, managing the county's Emergency Operations Center and 24/7 Watch Center, and by coordinating post-disaster recovery activities. OEM also provides emergency planning in such areas as special needs, continuity of operations and emergency operations.
Fairfax County Office of Public Affairs
12000 Government Center Parkway, Suite 551
Fairfax, VA 22035-0065
Contact: Merni Fitzgerald, Director of Public Affairs
703-324-3187, TTY 711, Fax 703-324-2010
Media Pager: 703-324-NEWS (6397)
Fairfax County is committed to
nondiscrimination on the basis of disability in all county programs,
services and activities. To request this information in an alternate
format, call the Office of Public Affairs at 703-324-3187, TTY 711.


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Adam Scott warmed up for the defence of his Masters title in stunning fashion with a course record-equalling 62 in the first round of the Arnold Palmer Invitational on Thursday.
Scott carded two eagles, seven birdies and one bogey at Bay Hill to claim the lead on 10 under par, matching the course record shared by Andy Bean (1981) and fellow Australian Greg Norman (1984).
"Obviously I'm really thrilled with the start," said world number two Scott, who is closing in on Tiger Woods at the top of the rankings. "It's maybe a little surprising. I don't know where it came from, but the putter certainly got hot."
Scott is making his first appearance at Bay Hill since 2009. He missed the cut in his last two starts and his only top-10 finish in six previous appearances came in 2004, when he tied for third.
"I just had a few frustrating years here and left it off the schedule," Scott told reporters after his round. "Coming back fresh was obviously a good thing. But I like the changes they've made since the time I have not been here and today was just one of those days where the hole was a bit like a bucket."
Scott revealed he had been suffering from flu-like symptoms for the past two days, but felt that might have been a positive rather than a negative.
"I went out there just trying to get the ball around," he added. "I've played a lot like this and sometimes it works in your favour because you have lower expectations."
Scott cannot overhaul the absent Woods - the defending champion pulled out on Tuesday with ongoing back problems - in the rankings with a victory on Sunday, but would claim top spot before the year's first major if both players did not compete again ahead of Augusta.
Scott started on the 10th and birdied his opening hole before picking up another shot on the par-five 12th after getting up and down from a greenside bunker.
He then holed from 25ft on the 14th and from a similar distance off the green on the next, before continuing his hot putting steak by making an eagle from 35ft on the par-five 16th.
The solitary bogey came from an errant approach to the 18th, but the 33-year-old bounced back quickly with a birdie from close range on the third and another eagle from 20ft on the fourth.
Further birdies on the sixth and seventh meant matching front and back nines of 31 and left Scott three ahead of Japan's Ryo Ishikawa and American John Merrick, with Spain's Gonzalo Fernandez-Castano, who also covered the back nine in 31, on six under.
England's Paul Casey and Welshman Jamie Donaldson were a shot further back on five under, with Ian Poulter and Graeme McDowell four under and European number one Henrik Stenson three under.
US Open champion Justin Rose and WGC-Cadillac Championship winner Patrick Reed, playing alongside Scott, shot 71 and 69 respectively, but Scott's predecessor as Masters champion, Bubba Watson, withdrew after an opening 83 - which contained an 11 on the par-five sixth - citing allergy problems.
English amateur Matthew Fitzpatrick returned a highly creditable 71, the 19-year-old from Sheffield carding three birdies and two bogeys.
"I felt quite composed, I didn't get down or get too upbeat," said Fitzpatrick, who claimed the silver medal as leading amateur in the Open Championship at Muirfield last year and then won the US Amateur title at Brookline.
That victory means Fitzpatrick has exemptions into three of the four majors in 2014 - the Masters, US Open and Open - as long as he remains an amateur. In January, he withdrew from Northwestern University to pursue a full-time amateur golf career.


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HOUSTON—You have to think that, after the bizarre three-minute press conference held by the NBA's players association here at the Hilton downtown, the members of that association are all too aware that their former leader, Billy Hunter, is not going down without a fight.
After union president Derek Fisher delivered his decidedly brief speech, he folded up his notes and walked away, without taking questions—most likely because he knew that the more anyone says on the situation that the NBPA is in, the more fodder they'll give Hunter should the whole mess wind up in the courts.
Hunter was voted out—unanimously—of his post as the union's executive director, a job he held for more than 16 years. He leaves amid scandal, as an internal investigation found that Hunter engaged in rampant nepotism, used union funds to prop up bad investments and, as the last straw, pushed through a contract for himself without going through proper channels. He is the subject of investigations by the New York State and U.S. attorneys general, as well as the Labor Department.
"No threats, no lies, no distractions will stop us from serving our membership," Fisher said. "We do not doubt that this process will possibly continue in an ugly way."
Hunter released a statement after his dismissal was announced, suggesting that he would be taking legal action.
"My legal team and I will begin carefully reviewing the actions taken and statements made against me in the meeting room in my absence," Hunter said. "I look forward to gathering the evidence showing how certain individuals made sure the outcome was pre-ordained."
Hunter obviously has a case. The internal investigation found no criminal wrongdoing by Hunter, only that he systematically put his own interests ahead of those of the players. Though his contract might be shady, it is legal. But when it came time for the players to vote on Hunter's case Saturday afternoon, Hunter was told he would be barred from the room.
That's why this thing isn't ending. Hunter should have been given a chance to defend himself in front of the group he has represented.
It was reported that Fisher, among others, worried that Hunter might talk his way into keeping his job, as though the players in the room were so misinformed and small-minded, they would not see past his bluster and look at the facts of the investigation when it came time to vote on him.
That is insulting to the union members, as if they could not be trusted to vote against giving millions to a charlatan selling them magic beans. Every player in the room knew Hunter's time was up, but by not letting him address the crowd first, the union leaves itself open for Hunter to sue.
Anyone who has watched Hunter during his tenure as the union chief knows that, now that the bridge has been burned, he won't hesitate to go after those who deposed him in court, no matter what dirt might have to be made public.
In fact, making dirt public might be his best weapon at this point.
During the last collective-bargaining negotiations, during which the rift between Hunter and Fisher became a chasm, word was leaked that Fisher was poised to sell out the union by accepting a bad deal for the players, in hopes that he would curry enough favor to get a front-office job when he retired.
It doesn't take a whole lot of dot-connecting to trace that story back to Hunter. Should a case hit the courts, expect more of the same.
Hunter's other most significant adversaries, the league's most prominent agents, could be dragged into the mess of a court case, too.
Arn Tellem, whose firm represents dozens of players, has been the most vocal and public critic of Hunter in recent years, but every major agent has maneuvered behind the scenes for Hunter's removal from office. If Hunter has dirt on any of them he could very well use it—and remember, agent vs. agent squabbles go through the union, so it is very likely he has dirt to share if he so chooses.
All in all, there were some positives to take out of the day for the NBPA. One of the strongest voices in the meeting was that of LeBron James, the league's biggest star. There was, top to bottom, a sense that players in the room needed to be more involved in their union, and give the job to someone on whom they will keep regular tabs, someone won't deal in the shadows the way Hunter did, someone who won't create and hide behind internal strife as a means of self-protection.
"We will no longer be divided, misled and misinformed," Fisher said. "This is our union. We're taking it back."
Unfortunately, though, they won't be taking it back without a fight.
"I do not consider today's vote the end," Hunter said, "only a different beginning."


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First it was Wayne Selden, then Noah Vonleh. Shortly after Vonleh, Andrew Wiggins followed.
Now, another high profile player from the class of 2014 will most likely be making his way to the class of 2013.
On Monday afternoon, word started to leak out that class of 2014 five-star center Dakari Johnson from Montverde (Fla.) Academy would make the move up to the class of 2013. By Monday night, several sources had confirmed that the 6-foot-10 Johnson would indeed be making the switch and that it would be confirmed by a press release from Montverde sometime within the next few days.
A true back-to-the-basket post man with sure hands and soft touch, Johnson will enter the class of 2013 ranked as the No. 13 player in the land. He is comfortable establishing position on either the right or the left block, never seems to be in a rush and is a very strong rebounder and positional defender.
Given that Johnson sat out his sophomore season at Montverde due to transfer rules after following head coach Kevin Boyle from Elizabeth (N.J.) St. Patrick, this puts him in a much different situation than some of the others.
For one, it means he'll enter college having only played two years of high school. Secondly, most who "moved up" a year such as Alex Murphy, Andre Dawkins, Andre Drummond, Nerlens Noel, Selden and Vonleh have simply elected to enter college with their original graduating class instead of taking a prep school year.
In the case of Johnson -- who just turned 17 last month -- he'll truly be skipping a year of high school after putting himself in a position to do so academically.
Despite the fact that he'll enter college with only two years of high school experience, there will be no shortage of interest in Johnson. He's been the recipient of outstanding coaching at the high school level under Boyle and frankly, he's ready physically and from a skill standpoint.
Among those expected to be involved are Florida, Kansas, Georgia, Georgetown, Kentucky, Louisville, Ohio State and pretty much every major program looking for a big man.
Bottom line, the already strong class of 2013 continues to benefit from an influx of 2014 talent, while the class of 2014 continues to suffer at the top due to the migrations of Johnson, Wiggins, Vonleh and Selden to 2013.
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Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Diabetes Complications Fatty Liver
|Drug: exenatide
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Effects Of Exenatide (Byetta®) On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Non-Alcoholic Fatty Liver Disease
- Reduction in Serum ALT From Baseline to 24 Weeks of Exenatide Therapy [ Time Frame: 24 weeks ]
- Changes in Components of Liver Histology at Baseline and Week 24 Including Steatosis, Inflammation and Fibrosis [ Time Frame: 24 weeks ]
Steatosis was grades on a scale of 0 (< 5%); 1 (5%- 33%); 2 (> 33% - 66%); and 3 (> 66%).
Inflammation was graded on a scale of 0 (No foci); 1 (< 2 foci per 200 X field); 2 (2-4 foci per 200 X field); and 3 (>4 foci per 200 X field) Fibrosis was graded on a scale of 0 (None); 1 (Mild periportal or perisinusoidal); 2 (Moderate periportal or perisinusoidal); 3 (Bridging fibrosis); and 4 (cirrhosis)
- Safety of Exenatide in Patients With NAFLD and Type 2 Diabetes [ Time Frame: 24 weeks ]
|Study Start Date:
|October 2007
|Study Completion Date:
|February 2010
|Primary Completion Date:
|July 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Exenatide
exenatide 5 µg BID s.c. daily for 28 days, followed by 10 µg BID s.c. daily from day 29 to week 24
Drug: exenatide
Subjects meeting the inclusion criteria will be treated with exenatide 5 µg BID s.c. for 3-7 days, followed by 10 µg BID s.c. daily to week 24
Other Name: BYETTA
Detailed Description:
Preliminary evidence suggests that exenatide (Byetta®) may have several beneficial direct and indirect effects on NAFLD and liver lipid metabolism. Ad hoc analysis of phase III studies has shown that exenatide treatment is associated with improvement and normalization of alanine aminotransferase (ALT), a marker of liver injury, and that this effect is most pronounced in those with the greatest weight loss. In addition, treatment of leptin deficient ob/ob mice with exenatide reduced weight, liver lipid content, serum ALT and liver lipid peroxidation. Additional evidence suggests that the effects of exenatide on the liver are not simply a result of weight loss, but rather due to direct effects on the liver. Hepatocytes express GLP-1 receptors that are responsive to both GLP-1 and exenatide. Furthermore, exenatide treatment of ob/ob mice or isolated hepatocytes reduces mRNA for stearoyl-CoA desaturase-1 (SCD-1) and SREBP-1c, which would be expected to reduce DNL.
Based upon this data, we hypothesize that exenatide treatment of diabetic patients with NAFLD and NASH will reduce liver injury through multiple mechanisms including weight reduction associated with exenatide, improved lipid metabolism by decreased expression of hepatic genes involved in DNL and reduction of adipokines and cytokines associated with severe NASH. This study is aimed to address the potential safety and efficacy of exenatide in the treatment of NAFLD and test these hypotheses.
This will be an open label, single-arm, non-comparative trial of 20 patients with type 2 diabetes and NAFLD treated with exenatide for 6 months with the following specific aims to be assessed:
Determine the safety and efficacy of 24 weeks of exenatide treatment in diabetic patients with Non-Alcoholic Fatty Liver Disease (NAFLD) Efficacy will be measured by changes in serum ALT (primary endpoint) and liver histology.
Characterize the effects of exenatide on serum levels of adipokines and inflammatory cytokines including adiponectin, leptin and TNF- in NAFLD patients.
Compare the hepatic expression of SCD1, SREBP-1c and PPAR- mRNA in NAFLD patients pre- and post-treatment with exenatide.
Establish the effects of exenatide on post-prandial lipid metabolism.
Determine the effects of exenatide on liver fibrosis in NAFLD.
|Ages Eligible for Study:
|18 Years to 70 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age >18 years, < 70 years, inclusive
- Type 2 diabetes on stable doses of sulfonylurea and/or metformin
- Body mass index > 35 kg/m2
- Presumed diagnosis of NAFLD based upon
- an ALT > 1.5 times the upper limit of reference range,
- no evidence of other causes of liver disease and
- ultrasound findings compatible with fatty liver
Exclusion Criteria:
- Clinical signs of cirrhosis as evidenced by any of the following
- spider angiomata,
- splenomegaly,
- ascites
- jaundice
- encephalopathy
- Platelet count < 100,000/ml
- Serum albumin < 3.0 g/dL
- Other liver disease including chronic viral hepatitis (B or C), alcohol abuse, hemochromatosis, alpha-1 antitrypsin deficiency, autoimmune hepatitis, Wilson's disease, primary sclerosing cholangitis or primary biliary cirrhosis.
- Current use of > 20 g of alcohol per day or unwillingness to avoid alcohol during the course of the study
- Treatment with a thiazolidinedione or exenatide within 6 months of enrolling in the study
- AST or ALT > 10 times the upper limit of normal
- Treatment with any investigational drug within 4 weeks of enrollment
- Pre-menopausal, fertile women unwilling to use contraceptives during the study period.
- Pregnancy or lactation
- Initiation or change in dose of hypolipidemic drugs (statins, niacin, cholestyramine are allowed) within 6 months of enrollment
- Use of anticoagulation, bleeding disorders or other contraindications to liver biopsy
Please refer to this study by its ClinicalTrials.gov identifier: NCT00529204
|United States, California
|University of California Davis Medical Center
|Sacramento, California, United States, 95817
|Principal Investigator:
|Christopher L Bowlus, MD
|University of California, Davis
|Principal Investigator:
|Lars Berglund, MD, PhD
|University of California, Davis
Additional Information:
|Responsible Party:
|University of California, Davis
|ClinicalTrials.gov Identifier:
|NCT00529204 History of Changes
|Other Study ID Numbers:
H80-MC-X006 ( Other Identifier: UC Davis )
|Study First Received:
|September 12, 2007
|Results First Received:
|December 8, 2014
|Last Updated:
|May 25, 2017
Keywords provided by University of California, Davis:
Fatty Liver
Nonalcoholic fatty liver disease
Additional relevant MeSH terms:
Liver Diseases
Fatty Liver
Non-alcoholic Fatty Liver Disease
Diabetes Complications
Digestive System Diseases
Diabetes Mellitus
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
ClinicalTrials.gov processed this record on September 21, 2017


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LA discussing Kershaw, Hanley deals; Tanaka on radar
LOS ANGELES -- Dodgers general manager Ned Colletti said he continues to have discussions with representatives for Clayton Kershaw and Hanley Ramirez regarding contract extensions, while also checking in on coveted Japanese right-hander Masahiro Tanaka.
Kershaw is eligible for salary arbitration for the final time. The two-time National League Cy Young Award winner reportedly balked at a $300 million lifetime contract that had strings attached, but Colletti said he has no indication that Kershaw doesn't want to remain with the Dodgers.
"We've had conversations for a while, and we'll see where they lead," Colletti said on Wednesday. "It's our desire to sign him here for a very long time."
Ramirez is under contract through 2014. Colletti said he's talked in general terms with Ramirez's agent, Adam Katz.
As for Tanaka, Colletti said he's had a couple of conversations with the pitcher's agent, Casey Close. Major League clubs have until Jan. 24 to sign Tanaka.
"They're in a feeling-out process," Colletti said. "They're trying to learn a lot about different cities, different markets, different teams, how teams are constructed, how teams are going forward. It's a big decision for the player, too. So we've had those types of conversations, and we'll continue and see how it goes."
The Dodgers are also in the market for an infielder. Colletti said he's looking for someone who can play second base and "give us versatility and a little more presence, somebody that can contribute sometimes on an everyday basis and sometimes off the bench."
Austin Laymance is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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StartUpHire is the place to find Engineering jobs in and near Hong Kong. Review the list of Engineering Hong Kong career opportunities to the left. These Engineering jobs represent some of the most rewarding careers available.
You can refine your job search for Engineering career opportunities in Hong Kong by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options.
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Your run style is as unique as you are. Use our shoe finder to find your match.
Our sports bras are designed to move with you comfortably, regardless of shape or size.
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John Pinette brings his stand-up comedy to the Ulster Performing Arts Center, 602 Broadway, Kingston, tonight starting at 8.
When describing his own stand-up, Pinette says, "I talk about my life; it is the funniest thing I can think of." His current comedy special "Still Hungry" debuted on Comedy Central in July and was released on DVD in August. The food-obsessed, storytelling Pinette, delivers smart, original, Bill Cosby-influenced observations on everyday life.
"Still Hungry" is a follow-up to his successful "I'm Starvin'!" and "Show Me the Buffet" CDs and DVDs.
Pinette is no rookie to the stage. For the past 16 years, he has been in entertainment in one way or another. Once he realized he could use his knack to make people laugh and turn it into a career, he left his job as an accountant and began touring comedy clubs around the country.
Pinette caught his big break when he was asked to tour with Frank Sinatra. He's since become a regular guest on "The Tonight Show" and "The View." Most recently, he moved from the theatrical stage and to stand-up after wrapping up his starring role as 'Edna Turnblad' in the winning Broadway musical "Hairspray." His acting credits include portraying a car-jack victim in the final episode of "Seinfeld."
Tickets are $37.50. Tickets are available at the UPAC box office or by calling (845) 339-6088. They can also be obtained at the Bardavon Box Office, 35 Market St., Poughkeepsie, or by calling (845) 473-2072, Tickets are also available by calling TicketMaster at (800) 745-3000 or by going to www.ticketmaster.com.


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When St. Louis Cardinals manager Mike Matheny says collision plays at the plate should be outlawed, baseball should listen.
Matheny is a retired catcher whose career ended prematurely because of post-concussion symptoms. Now in his second season as a manager, Matheny only recently changed his thinking about plays at the plate.
"I love that play, so this is hard for me to say," Matheny told reporters Tuesday, according to the St. Louis Post-Dispatch. "I don't see the sense of it. I do believe that this game will get to the point where there will no longer be a collision at the plate. And I am 100 percent in support of that."
— PHOTOS: Bang-bang plays at the plate; must-see collisions
Matheny has shared his changed view with former manager Tony La Russa, who now works for the commissioner, and other baseball officials. Matheny plans to meet with Joe Torre later in spring training. As executive vice president of baseball operations, Torre would be in position to oversee a change.
"If something is going to make the game safer and not affect the way the game is played, I'm certainly all for it," Torre told The San Francisco Chronicle. "I really haven't heard that thing that would make us change."
Matheny's idea for change is simple: Treat the plate like any other base. No more charging head-on into a defenseless catcher standing at the plate.
"It's a tag play," Matheny told reporters. "You get in position to make a tag like a third baseman. No one is going to (level) a third baseman. I'd love to hear the rebuttal. What I personally witnessed is enough to change my mind. It took me a little longer to get to the realization of risk we're putting these guys in."
Matheny says he had to "eat some crow" when he told La Russa, a proponent of outlawing collisions, about his changed stance. Matheny says a stepped-up awareness of concussions in the NFL and other sports also has helped him change his perspective.
"That sport doesn't have the option. We have an option," Matheny said.
Though baseball could make such a change quickly, this likely is another issue that will remain under study for some time.
San Francisco Giants manager Bruce Bochy, another former catcher, is one who has been calling for change since Buster Posey's season-ending broken left leg in a home-plate collision in 2011. So far, though, Bochy has made little progress.
Getting others such as Matheny behind a change could speed up the process. Let's hope so.


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Securing Your OPC Classic Control System
Independent Techniques for Ensuring Strong Security in Your System
OPC Classic is a software interface technology used to facilitate the transfer of data between different industrial control systems. It is widely used to interconnect Human Machine Interface (HMI) workstations, data historians and other hosts on the control network with enterprise databases, Enterprise Resource Planning (ERP) systems and other business-oriented software. Unfortunately, securely deploying OPC Classic has proven to be a challenge.
This article describes two independent techniques for ensuring strong security in systems using OPC Classic technology. This first creates zone-based defenses using OPC-aware firewalls. The second takes advantages of improvement in the Windows operating system to managing OPC accounts and permissions. Both security techniques are available and proven for use in today's control systems.
OPC Classic – The World's Leading Industrial Integration Standard
Formerly known as OLE for Process Control, (where OLE stood for Object Linking and Embedding), OPC Classic was developed in 1996 in response to a demand for standard methods to allow different control systems to interface with each other. Today it has grown to be the world's leading technology for integrating different automation products.
No single industrial communications standard has achieved the widespread acceptance across so many different verticals, industries and equipment manufacturers as OPC Classic. It is used to interconnect an amazing variety of industrial and business systems, ranging from Human Machine Interface (HMI) workstations, Safety Instrumented Systems (SIS) and Distributed Control Systems (DCS) on the plant floor, to enterprise databases, ERP systems and other business-oriented software in the corporate world.
The reason for OPC's wide spread popularity has been simple – it is the only truly universal interface for communicating with diverse industrial devices and applications, regardless of manufacturer, software or protocols used in the control system. Before OPC Classic was developed, developers had to create specific communications drivers for each control system they wished to connect with. For example, one HMI vendor developed over 200 drivers for different DCS and PLC systems in the pre-OPC days. Now they focus their efforts on a single optimized OPC driver for their product, which then communicates to other OPC servers designed and sold by the manufacturers of the other control products.
For the end user, a significant advantage of using OPC is not having to directly deal with the control device's internal architecture. In other words, integration teams can work with named items (or groups of items) across multiple product lines, instead of dealing with raw register locations (e.g. 40020 or N7:2) and data types (e.g. 32-bit integer or IEEE floating point). This allows for an easier job when adding or changing control systems, such as when migrating from a proprietary protocol to an Ethernet-based protocol.
Most engineers soon found using OPC saved significant time during configuration, as compared to using traditional communications technologies. The result of all this is that it is rare to find an industrial facility today that isn't using OPC for some portion of its system integration strategy.
What is OPC Classic Anyway?
The term "OPC Classic" refers to all OPC standards prior to the new OPC-Unified Architecture (OPC-UA) standard. This includes the most popular specifications such as OPC Data Access (OPC DA), OPC Alarms and Events (OPC A&E) and OPC Historical Data Access (OPC HDA).
What sets OPC Classic apart from the emerging OPC-UA standards is that OPC Classic is based on Microsoft's Distributed Component Object Model (DCOM) technology. DCOM in turn, is the culmination of a number of other technologies including Component Object Model (COM) and Object Linking and Embedding (OLE). All these technologies use a network protocol called Remote Procedure Call (RPC) to connect over a typical Ethernet/TCPIP industrial network.
One of the important things to understand about OPC is it is an Application Programming Interface (API) and not an "on the wire" protocol. Instead the underlying DCOM and RPC technologies are the real "protocols". OPC is at a higher level of abstraction than true communications protocols such as Ethernet, TCP/IP or RPC.
All OPC technology is based on a client/server architecture where computers run software that makes them either a client or a server (or both in some cases). The OPC server is a software application that gathers information from a device (such as PLC, DCS or SCADA controller) using that device's native protocols (such as Modbus or PROFIBUS). The server then provides access to this data via COM objects and method calls, allowing multiple OPC clients to indirectly read and write to the field device via the OPC server.
An OPC client is an application that accesses the data held by OPC servers. An HMI package may contain an OPC client that allows it to access data provided by an OPC server application resident on another computer. The HMI package could also act as an OPC server, allowing other OPC clients to access the data it has aggregated either directly from field controllers or from other OPC servers.
To illustrate this client-server architecture, imagine a simple system with three basic components designed for controlling the water level in a tank:
• A Modbus-capable PLC performing the actual control functions
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NCAR is a crossroads for scientific interaction and collaboration. We work closely with universities, environmental research and assessment programs, government laboratories, and other international and national research institutions to define grand challenge problems in the atmospheric, solar, and related sciences; and we collaborate with these partners to organize and support communities of leading experts in sustained, long-term projects that address such problems. We maintain strong ties to innovative researchers and other centers of excellence, nationally and internationally, and include our partners in decision making and direction setting for our institution. Successful implementation of this plan depends on close and ongoing engagement with a wide variety of scientific partners.
NCAR is also a venue for the interaction of science and society. Our partnerships and interactions with decision makers in business and industry; nongovernmental organizations; and local, national, and international governmental bodies and agencies are steadily increasing. We consider policy questions and societal issues as we develop research plans. We investigate decision making processes and develop decision-support mechanisms to help ensure efficient and effective applications of science to societal needs. We embrace both research and operational goals in model development. We reach out to diverse groups interested in the atmospheric and Earth system sciences, conduct our work in an open and transparent manner, and proactively inform the public about our programs and results. We see active engagement with stakeholders who can use and benefit from our work as a fundamental responsibility.


text:
Dip-Buyers Are Spooked
The market is oversold. There's strong sentiment and housing numbers. Fed chief Ben Bernanke has indicated a willingness to continue printing money. Despite all this, there's limited buying interest and the market is hardly bouncing.
It's clear that yesterday's ugly selloff and poor close spooked the dip-buyers. They are afraid of being caught in a failed bounce like Friday and Monday morning, so they are standing aside until someone else shows a willingness to jump in....109 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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text: Collection Thomas Mason® for J.Crew embellished top Item E9247 Size: All sizes are US sizes. Size Charts Quantity: 1 2 3 4 5 6 7 8 9 Prices do not include taxes. Add to Bag Wishlist Add to Bag Add To Wishlist share: size & fit Body length: 26 1/2". Product Details A summer-ready top crafted in Italian cotton from Thomas Mason, one of Europe's oldest and most legendary mills that's been weaving some of the best shirting since 1796 (when George Washington was alive!). We love the embellished bib, featuring meticulously applied jewels and stones for a quirky J.Crew twist. Italian cotton. Dry clean. Import. Select stores. Item E9247.


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The SimplyVibe V4-94P Bluetooth Table Speaker Stand is ideal for watching movies, playing games or typing emails. The stand allows you to easily adjust the position vertically or horizontally by simply tilting it forward or backward. When the speakers are paired to your tablet, you enjoy a much fuller and richer sound than the built-in tablet speakers. The long-lasting battery life means you can take this anywhere wirelessly.
Supports AUX Line In: 3mm input Output power rms: 3W x 2
Speaker impedance: 4 ohm x 2
Frequency response: 120Hz-13KHz
Speaker size: φ45MM x 2
Charging: DC 5V
Comes with: Color box, User manual, AUX cable, Interchangeable rubber clips, Charging cable
|In Depth
|Technical Details
The SimplyVibe Tablet Speaker Stand allows both horizontal and vertical viewing positions
Bluetooth speakers significantly amplifies the built-in iPad or Galaxy Tab speakers
Fits 10" iPad or Samsung Galaxy Tab (includes interchangeable rubber clips)
Built-in rechargeable batteries can last up to 12 hours of continuos play time
Output power: 3 Watts, Impedance: 4 Ohms, Battery: 1500mAh


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Oregon State baseball Media Day
CORVALLIS, Ore. - The message was clear at Oregon State baseball Media Day, this season is all about getting to Omaha.
The Beavers will enter the season ranked No. 6 by Baseball America, the highest ranking of any Pac-12 team.
With several key players returning, Oregon State has great expectations, but head coach Pat Casey wants his team to prove it on the field.
"I always say what they used to run around the minor league ball parks, prospect is suspect that you don't expect," said Casey, who is returning for his 19th season as Oregon State's head coach. "I don't for any reason see why we cant be a good baseball team."
The Beavers are coming off a 40-20 season in 2012, but their postseason run was cut short when they lost a 10-inning elimination game against LSU in the Regional Round.
"As soon as that last pitch was thrown at LSU, I think we've been real hungry to get back out there," said Ben Wetzler. "We didn't like the feeling that we had there."
Wetzler is expected to be the number one pitcher in the Oregon State rotation after he went 8-2 with a 3.10 ERA in 2012.
Click on the video tab above to watch Pat Casey preview the Beavers season.


text:
Don't miss out on a lower price on this hotel
Get an overview of this hotel4-star Cape Town hotel in Fresnaye, near Cape Town Stadium
Popular property highlights
Located in Fresnaye, this hotel is 0.7 mi (1.1 km) from Sea Point Swimming Pool and within 3 mi (5 km) of Cape Town Stadium and Two Oceans Aquarium. Greenmarket Square and Cape Town International Convention Centre are also within 3 mi (5 km).
Hotel Features
This hotel features a restaurant, an outdoor pool, and a fitness center. Free full breakfast is provided, as well as free WiFi in public areas, free self parking, and a free manager's reception. Additionally, a bar/lounge, a poolside bar, and a coffee shop/café are onsite.
Room Amenities
All 36 rooms have plasma TVs with satellite channels and feature kitchens with refrigerators, stovetops, and microwaves. Guests will also find free WiFi, Select Comfort beds, and dining areas.
Guest Highlights
- Spotless guestrooms
- Good location
- Beach
- Breakfast
- Pool
- Convenient parking
- Helpful staff
The Hyde All-Suite Hotel
Hotel Amenities
Hotel Amenities
The Hyde All-Suite Hotel features an outdoor pool and a fitness center. The hotel offers a restaurant and a coffee shop/café. Guests can unwind with a drink at one of the hotel's bars, which include a poolside bar and a bar/lounge. Guests can enjoy a complimentary breakfast each morning as well as a complimentary manager's reception. Public areas are equipped with complimentary wired and wireless Internet access.
Business-related amenities at this 4-star property consist of a 24-hour business center and meeting rooms. Event facilities measuring 861 square feet (80 square meters) include a conference center. This business-friendly hotel also offers a rooftop terrace, tour/ticket assistance, and multilingual staff. For a surcharge, the property provides a roundtrip airport shuttle (available 24 hours) and an area shuttle. Onsite self parking is complimentary. The property may provide extended parking privileges to guests after check-out (surcharge).
- 24-hour front desk
- Babysitting or childcare (surcharge)
- Airport transportation (surcharge)
- Total number of rooms - 36
- Number of floors - 6
- Babysitting or childcare
- Bar/lounge
- Coffee/tea in common areas
- Coffee shop or café
- Free newspapers in lobby
- Free breakfast
- Concierge services
- Conference space
- Elevator/lift
- Fitness facilities
- Tours/ticket assistance
- Free WiFi
- Free wired Internet
- Pool umbrellas
- Area shuttle (surcharge)
- Dry cleaning/laundry service
- Rooftop terrace
- Luggage storage
- Restaurant
- Garden
- Laundry facilities
- Meeting rooms 2
- Multilingual staff
- Poolside bar
- Porter/bellhop
- Safe-deposit box at front desk
- Train station pickup (surcharge)
- Pool sun loungers
- Free long-term parking
- Conference space size (meters) - 80
- Free reception
- 24-hour business center
- Conference space size (feet) - 861
- Free self parking
- Conference center
- Year Built 2008
- Number of buildings/towers - 1
- Outdoor pool
- Television in common areas
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Free Wi-Fi
- Kitchen
- Laundry facilities
- Babysitting or childcare (surcharge)
- In-room childcare (surcharge)
- Separate dining area
- Full-sized refrigerator/freezer
- Microwave
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi , Free wired Internet
Free long-term parking, Free self parking
Room Amenities
- Premium bedding
- Separate sitting area
- Air conditioning
- Free newspaper
- Access via exterior corridors
- Phone
- Minibar
- Coffee/tea maker
- Kitchen
- Microwave
- Daily housekeeping
- Turndown service
- Private bathroom
- Bathrobes
- Free toiletries
- Hair dryer
- In-room massage available
- Shower only
- In-room childcare (surcharge)
- In-room safe
- Iron/ironing board (on request)
- Portable fan
- Cookware, dishware, and utensils
- Blackout drapes/curtains
- Separate dining area
- Full-sized refrigerator/freezer
- Stovetop
- Satellite TV service
- Free WiFi
- Down comforter
- Sleep Number by Select Comfort mattress
- Plasma TV
- Heating
Where to Eat
A complimentary full breakfast is served each morning between 7 AM and 10:30 AM. An additional breakfast (subject to charges) is served daily. A complimentary manager's reception is offered each day.
H13 - This family restaurant serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar. A children's menu is available. Happy hour is offered. Open daily.
Nearby Things to Do
Recreational amenities at the hotel include an outdoor pool and a fitness center.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Windsurfing nearby
- Kayaking nearby
- Sailing nearby
- Surfing/boogie boarding nearby
- Bicycle rentals nearby
- Scooter/moped rentals nearby
- Hiking/biking trails nearby
- Mountain biking nearby
- Skydiving nearby
- Parasailing nearby
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- In-room accessibility
Hotel Policies
Check-in time starts at 2 PM
Check-in time ends at 5:30 AM
Special check-in instructions:
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! One child 3 years old or younger stays free when using existing bedding.
- Rollaway/extra beds are available for ZAR 400 per night.
- Cribs (infant beds) are available for ZAR 100 per night.
- Pets not allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
- Deposit: ZAR 200.00 per night
Optional extras
- Airport shuttle fee: ZAR 400 per room (one way)
- Late check-out fee: ZAR 100
- Crib (infant bed) fee: ZAR 100 per night
- Rollaway bed fee: ZAR 400 per night
Hotel Name
- Hyde All-Suite
- Hyde All-Suite Cape Town
- Hyde All-Suite Hotel
- Hyde All-Suite Hotel Cape Town
- The Hyde All Hotel Sea Point
- The Hyde All-Suite Hotel Cape Town, South Africa
- The Hyde All Suite Hotel
We should mention
This property offers transfers from the airport (surcharges may apply). Guests must contact the property with arrival details before travel, using the contact information on the booking confirmation. One child 3 years old or younger stays free when occupying the parent or guardian's room, using existing bedding. Only registered guests are allowed in the guestrooms.
National Rating
Quality Graded by the Tourism Grading Council of South Africa (TGCSA) – South Africa's official quality assurance organization.


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SEATTLE (AP) -- George Kottaras and Brett Anderson are making the most of their second chances, keeping the surprising Oakland Athletics in the playoff chase.
Kottaras homered for the second straight game and Anderson won his fourth straight start since recovering from Tommy John surgery as they helped the A's beat the Seattle Mariners 6-1 Saturday night.
Anderson (4-0), who had surgery on his left elbow 14 months ago, allowed one unearned run and six hits while striking out four in six innings. He lowered his ERA to 0.69. He has 19 strikeouts in his four starts.
''I think it's been more than we could ever expect,'' A's manager Bob Melvin said of Anderson's recovery. ''To sit here and say he's 4-0 at this point coming off that is pretty terrific.''
Kottaras, acquired July 29 in a trade with Milwaukee, has had an offensive revival with the A's. He has had 16 RBI in his 13 games with Oakland - 13 in the last five games. With the Brewers, he drove in just 12 runs in 58 games.
With the score tied 1-1, Yoenis Cespedes opened Oakland's fourth with a double into the left-field corner. With one out, he stole third on a 1-0 pitch to Stephen Drew, who followed with a RBI single against the drawn-in infield. The ball just tipped off the glove of second baseman Dustin Ackley.
Kottaras then hit a 1-1 slider from Hisashi Iwakuma (6-4) for a two-run, line shot into the right-field seats to make it 4-1. It was his fifth home run of the season, and came one day after he had a three-run shot in the same inning Friday during the A's 6-1 victory. It was the first time he hit a home run in back-to-back games.
''He's been pretty amazing,'' Melvin said. ''You look at his average (.222) then you look at his home run numbers and RBIs. It seems like every home run he has hit for us has been a big home run. And tonight's home run really had the same affect as last night's home run.''
Both home runs gave the needed room for the A's starters to work. He hit his three-run home run Friday off Felix Hernandez. He hit his two-run shot off Iwakuma, who was 5-1 with a 1.57 ERA in his last seven starts. He was 3-1 with a 2.05 ERA in five August starts.
''Iwakuma has been pitching lights out,'' Melvin said. ''He's been giving up two runs or less just about every game so he's been on a roll. For us to score some runs early again off of him was pretty impressive as it was off Felix.''
Iwakuma, who worked 3 2-3 innings, allowing four earned runs and six hits, said through an interpreter that the slider Kottaras hit ''was kind of a cookie, kind of easy to get a home run. I need to concentrate on that pitch.''
Coco Crisp had a run-scoring double after Kottaras' homer that gave Oakland a 5-1 lead.
The A's kept pace in the AL West with the Texas Rangers, who beat Tampa Bay 4-2. Oakland trails the Rangers by 4 1/2 games and are in a virtual tie with the Yankees and Orioles atop the wild-card race.
''Oh, he looked pretty good to me,'' Mariners manager Eric Wedge said of Anderson's effort. ''He did a good job with his fastball. He has a lot of confidence with that breaking ball he throws. He controlled the tempo of the game.''
Seattle finished 0 for 7 with runners in scoring position.
''I always hold myself to a high standard. You have to in this game, otherwise the game's going to beat you up,'' Anderson said. ''Today was my most grinding start so far. It seemed like it was first and second one out every inning.
Anderson and Kottaras have had significant roles in helping the A's win 17 of their last 22 games. Their 78 wins are also four more than all of last season.
''Definitely getting more frequent at-bats helps,'' Kottaras said. ''I just taking advantage of mistakes that are tossed up there.
''I think I've gelled pretty good with the guys and doing what I can to help and have a good time.''
The A's forced Iwakuma to throw 25 pitches in the first inning and scored a run without a hit.
Crisp opened with an eight-pitch walk. He was forced at second on Josh Reddick's grounder. Cespedes followed with a two-out, one-hopper past third baseman Kyle Seager and into the left-field corner. It was ruled a two-base error, scoring Reddick.
The Mariners tied it in the second. Michael Saunders bounced a one-out double over the center-field wall. Miguel Olivo reached when shortstop Drew booted his ground ball, advancing Saunders to third. He then scored on Trayvon Robinson's force-out.
Cespedes added a sacrifice fly in the ninth.
NOTES: A's RHP Brandon McCarthy, hit in the head by a line drive Wednesday, is showing good progress after his surgery to reduce brain swelling. ''I'd give him one more day (until he's out of the woods),'' trainer Nick Paparesta said. ''I think with any head injury you need to be cautious ... but the progress has been great and we're all very excited about it.'' A's manager Bob Melvin, who gathered the team together before the game for a medical update, said, ''It puts a smile on your face.'' ... Reddick's single in the ninth snapped an 0-for-18 slump. ... Wedge said rookie RHP Erasmo Ramirez, a September callup, will start Tuesday at Toronto. Hector Noesi also will be worked into the rotation. ''We just want to take a look at them again,'' Wedge said. ''It's a chance to watch them a little longer.'' ... Mariners LH reliever Oliver Perez has not allowed a run in his last 18 appearances (13.1 innings), or since July 8. That's tied for the seventh-longest streak in club history.