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Project Governance
The University of Alaska system is wide spread across Alaska with 3 separate accredited institutions and over a dozen rural campuses. The IT network infrastructure at UA connects the multiple campuses to the internet, instructional technologies, voice and data services, and administrative computing. UA is regularly pursuing advancements to optimize the IT performance connecting the campuses, faculty, and students. To accommodate the large volume and high capital costs of UA's major IT related initiatives and endeavors, a governance structure was created as a planning and reporting framework. The IT governance structure is made up of the Information Technology Executive Council (ITEC), The CIO Management Team (CMT), and the Portfolio Management Team (PMT – currently inactive).
The Information Technology Executive Council (ITEC) provides direction and a strategic framework for IT projects. The goal of ITEC is to foster development, continuously monitor, and evaluate all of the major UA technology endeavors. ITEC serves as the executive body for UA IT departments and is responsible for funding and prioritizing projects.
The CIO Management Team (CMT) defines UA IT policies, standards, and communications. The CMT serves as the planning body for UA IT by working to ensure that technology initiatives are in line with the business needs of the University.
Other governing bodies such as the Student Services Council, the Statewide Academic Council, and the Business Council may also have input on specific projects.
Diagram of the IT Decision Tree for Small Projects within the UA System
UA ITEC Decision Tree for Small Projects


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Alltech New Mexico Announces Eric Hibbard as Regional Sales Manager
[LEXINGTON, Ky.] – Global animal health and nutrition company Alltech is proud to appoint Eric Hibbard as the new sales manager for Alltech New Mexico.
Hibbard was raised on a family dairy near Gilbert, Ariz., and following high school, Hibbard attended Central Arizona College on a baseball scholarship. Graduating in 2009 with a bachelor's degree in agriculture economics and business management, Hibbard worked at the University of Arizona Dairy Extension Department and, in 2011, joined Alltech as the territory sales representative for Arizona and Southern California. Hibbard specializes in calf management and heat stress and has completed courses from the Southern Great Plains Dairy Consortium in Clovis, N.M.
"Coming from a farming background myself, I value strong relationships with peers in the industry because, at the end of the day, we all have to bring value to our operations and we're all in the business together. I'm looking forward to meeting the farms in the area and servicing them with Alltech's holistic support approach including a wide of technologies and on-farm services," Hibbard said.
Alltech's New Mexico office located in Clovis, services the territories of New Mexico, Texas, Colorado, Kansas, Oklahoma and Louisiana.

subset: commoncrawl


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Developed for the high fuel cost environments of northern Europe, the Biasi B-10 boiler has proven to be a fuel efficient and reliable heating option. These same great boilers are now available here in North America. With an innovative three pass heat exchanger design, the Biasi B-10 boiler can save up to 40% over older single pass style models. With a high quality GG20 heat exchanger, and certifications from the ASME and UL, you can be sure the B-10 will be a safe, long lasting heating solution for your home.
Product Features
3 Pass Heat Exchanger
A 3-pass boiler design is the most efficient way to get the maximum amount of heat from the fuel. There is three times as much interior surface area compared to a single pass boiler which in return, leads to being more fuel efficient.
This boiler is made out of GG20 cast-iron to ensure longevity of your boiler. This cast-iron also has superior heat retention which helps get the most out of your fuel.
Big Things Come in Small Packages
Biasi engineers pride themselves on how compact their boilers are. With it's small compact size and low water content, the B-10 boiler can fit just about anywhere you would like.
Product Includes


text:
scenes from the weekend
I hope you all enjoyed your weekends. Here's a bit of ours.
We bought Israel a new toy, I enjoy buying things for him way more than me!
I sequined vintage sweater I found at a thrift store with the tags still on.
A little update on Israel, he's starting to get some hair, yay!
Remnant of a little project and my new Lotta Jansdotter tote.
Other Stories
4 comments:
This comment has been removed by a blog administrator.ReplyDelete
I love the idea of how different the toy is from that beautiful vintage sweater and yet also how they are so perfectly paired as a reflection of your interests as well as weekend. Pretty neat. :)ReplyDelete
your son looks like a little baby bird with that adorable fuzz on his head. so cute.ReplyDelete
How adorable is your little one :)ReplyDelete
thank you for your comments!
if you have any questions please email me via the 'contact' link.


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Source distribution as a zip file
Source distribution as a tar.gz file
awspylib is a python based library to interact with amazon web services. Currently, it only supports amazon's Simple Storage Service (S3).
awspylib has been developed and tested with python2.5.1 on both Windows XP and Ubuntu 7.1 (Gusty Gibbons). It has also been tested with am EC3 ubuntu7.1 image.
The main use case focus for the development of awspylib has been more "back end" focused. The current implementation of the interface to S3 is really focused on allowing the backup and synchronization of a local file system to S3.
The goal is to next integrate awspylib with PyiNotify to create a low cost, lightweight way to back up changes to local file systems on a EC2 image to S3 and to automatically restore these changes on the restart of an EC2 instance
Included with the library is a CLI based tool (s3_cli.py)


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found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am up to date with shots.
Ruby, a Waleska Quarterhorse was adopted! Here's how you can benefit by looking at adoption as an option to buying a Quarterhorse for sale in Waleska, or seeking a Quarterhorse from a breeder in Waleska.


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F1 Fanatic - F1
Tagged: Sky, Sky F1, Virgin Media, Virgin Media F1
This topic contains 30 replies, has 21 voices, and was last updated by Matthew 5 years, 7 months ago.
According to Virgin Media, they will have Sky's F1 channel this year:
"The channel will be added to the complete Sky Sports package available through Virgin Media, alongside Sky Sports 1, Sky Sports 2, Sky Sports 3 and Sky Sports 4. Subscribers to this package will have the channel added automatically at launch. Sky Sports News is separately included in all pay TV tiers."
Can anyone who knows about Virgin Media work out how much it will cost?
£22.50 per month for the full Sky Sports package assuming you don't already have it – so £270 for a year.
on top of whatever package you're already using, sky sports collection is £22.50 extra a month with M+, L and XL packages, and £28.00 with the M packaged, plus another £7 on top for HD.
Source: http://shop.virginmedia.com/digital-tv/channels/sky-sports.html
Too much for lots of sky sports chanels I wont watch. I long for the day they offer a racing package, and not bundle it in with the football channels.
I won't be paying that thank you! I think I'll just move over to sky once my contract is up.
Until then I'll watch F1 via Sky Go on my folks sky account.
Edit: Infact, anyone else disappointed with the offer – email firstname.lastname@example.com with your opinions. I have.
I'm already with Virgin Media for my Broadband, so somthing like this would be the only way I'd be getting the F1 this year, instead of having to sign up with Sky direct.
But it's still too much money for very little content that I will hardly ever watch.
If sky themselves aren't carrying it as a separate channel, why do you expect virgin to?
Cheapest way to get Sky F1 is:
M+ Tv pack £12.50pm + Sky sports pack £22.50pm = £35.00pm.
So £4.75 more expensive than it is on Sky plus the Virgin will be carrying the SD channel, not the HD channel.
Also that is with the V-HD box so no recording tv like Sky+
Personally I think its a bit of a poor deal, but it is the one I was expecting.
Yup, unfortunately Sky holds all the cards – it's a very poor deal they're offering Virgin Media customers.
Just seen on the VM twitter. someone queried that with Virginmedia that they'd be paying more with them for the SD channel than I would the hd channel with Sky & they replied
"No HD content on Sky for us but you can watch half the races in HD on BBC1"
Wow telling customers to pay £22.50 for the Sky pack, only then to say watch half the races on the Beeb.
That's left me speechless
Again, if sky aren't offering them the HD channel, then virgins can't. Help that.
Actually the cheapest way to get SKY F1 is just
Or another cheap way is £15 a month on the xbox with Sky Go which you can also watch on your laptop
Never said it was Virgin's fault.
Just said it was a poor deal and having the audacity to suggest we should watch half the races on the Beeb while subscribing to the Sky F1 channel was a major kick in the teeth.
At least Virgin seems to be doing what they can to stay in touch with the viewers, even though its no super deal for them or their viewers. It shows how Steve Rider is right in what he says about that deal in this interview (from about 6:42 in its about the BBC/Sky deal – he certainly is not buying the line the BBC had no choice) – might be slightly off topic, but its a great interview.
It's a terrible deal.
Sorry but one hour of Race action (as confirmed in Ben Edwards interview) is appalling.
It's not enough, you cannot tell a good story with approx 2 thirds – half the race.
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Tulsa's G.J. Kinne Is Third C-USA QB Named to Manning Award Watch List
Sunday, August 1, 2010
For the first time in his four years at Tulsa, head coach Todd Graham returns his starting quarterback, the talented G.J. Kinne (official bio), who led the Golden Hurricane in rushing and passing as a sophomore. Kinne, who transferred to Tulsa from Texas, was a midseason addition to the Manning Watch List last year. The Manning Award, sponsored by the Allstate Sugar Bowl, is releasing the Watch List one player per day through its official Facebook and Twitter pages. The award has honored the top quarterback in the nation for the past six years.
Manning Award Watch List (Final)
2010-11 Manning Award Watch List Photo Gallery


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The City Different is the same as hundreds of other American cities and towns in this respect at least: It has had a long, flickering flirtation with the idea of a French bistro. Nobody knows what a bistro really is anymore, maybe not even the French themselves, but here in the States, its minimal requirements would seem to be the word "bistro" in its name; an espresso machine, working or merely ornamental; a basketful of thickly sliced bread; French fries; and at least one variety of French wine (poster of the Eiffel Tower optional).
Nobody now living can recall how many local restaurants have fulfilled these requirements—dozens, surely.
And now Santa Fe has its newest iteration—but this one promises to be different. Bouche, the creation of well-known local chef Charles Dale, is set to open on Tuesday, Feb. 26 in the West Alameda space formerly occupied by Aqua Santa.
"We have all of these [requirements]," Dale says cheerfully, "except the Eiffel Tower."
French-born and raised, Dale has his own set of essentials, gathered through the years when he apprenticed in kitchens in Lyons (perhaps the bistro capital of France), Paris and New York's pricey Le Cirque. To refresh his memory of how things should be done, he took two research trips to Paris last year, dining at such classics as L'Ami Louis as well as some of the newer versions.
"A bistro must be small," Dale says, "intimate in feeling. People should be tightly seated; the atmosphere should be slightly raucous. After all, these places are meant to be fun." This is good news to those of us here who have endured the sepulchral hush of some of Santa Fe's starchier establishments.
Atmospherics aside, Dale believes an authentic bistro must offer the following items—if not always, then with some consistency: roasted chicken, escargot, steak tartare, confit of duck, steak-frites and some form of foie gras. In a nod to changing tastes, he will also offer at lest one vegetarian entrée. These will form the core of his menu, and will complement nightly blackboard specials like coq au vin and what he calls "bistro cuts," such as sweetbreads and calf's liver.
As for the bread and wine, Dale has been fortunate enough to retain the services of Aqua Santa's baker, whose crusty, flavorful bread clients will happily recall. He's also assembled a wine list of French and American bottles that aspires to be "the best value in town, but not necessarily the cheapest," along with a good selection of wines by the glass.
During the summer, diners can enjoy a completely redone patio, as well as some menu changes that reflect both the season and Dale's Provençal background. To judge from the sample menu I saw, you probably couldn't expect to get the full Bouche experience for less than $100 for two, sans wine.
Dale knows the Santa Fe gastro scene well from his years at Terra at Rancho Encantado, so he's aware of the history regarding our flirtation with French-style restaurants.
"My goal here," he says, "is to create a kind of microcosm within the wider community, so that when you walk into Bouche, you feel you're walking into a Parisian bistro, minus the French accents. Of course, one has to remember that this is a tourist destination as well as a town with its own traditions. When people dine out here, they expect New Mexico-style food. But this is the kind of challenge I love."
451 W Alameda St., 982-6297
Opens on Tuesday, Feb. 26


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IBM Certified System Administrator - Connections 4.0
Job Role Description / Target Audience
This intermediate level certification is intended for system administrators who plan for and perform the installation, configuration and day-to-day tasks associated with ensuring the smooth and efficient operation of an IBM Connections 4.0 environment. This includes tasks associated with:
- Architecture
- Installation and Migration
- Security
- General Administration
- Configuration and Customization
- Integration
- Troubleshooting
This administrator is generally self-sufficient and is able to perform most of the tasks involved in the role with limited assistance from peers, product documentation and vendor support services.
Recommended Prerequisite Skills
Prerequisite skills required:
- A working knowledge of IBM WebSphere Application Server, including but not limited to: the Integrated Solutions Console and WSAdmin commands.
- An understanding of the relationships between IBM Connections 4.0, WebSphere Application Server, IBM Tivoli Directory Integrator, and LDAP.
- A working knowledge of database software and architecture.
- A basic understanding of how Connections 4.0 may integrate with other products (e.g., IBM Lotus Sametime, IBM Lotus Notes, IBM Lotus Domino, IBM WebSphere Portal).
- A working knowledge of security protocols, including but not limited to securing web applications with SSL.
This certification requires 1 test(s).
Test(s) required:
Click on the link(s) below to see test details, test objectives, suggested training and sample tests.
Member Site
Not sure what the Member site is? Find out the benefits of being a certified professional.
Premium Certification
Show off your Certification!


text:
Major Responsibilities:
You will be consulting some of Check Point's largest customers about product integration. You will provide training and implementation of Check Point's High-End products in complex networking environments. The work will consist of visits to customer locations, where you will be required to quickly understand the deployed topology, and perform the work per the customers needs. As you become more familiar with the product, there may be opportunities to provide training to customers as well. 50% travel.
Desired Background & Experience:
--5-7 years experience with IP based networks, network design, and security products.
--Experience with several different operating systems: Windows 9x/2000/XP, Unix- based.
--Extensive troubleshooting experience required.
--Experience with Check Point products preferred.
--Strong VSX, Provider-1, and XBM experience needed.
--Strong TCP/IP understanding and knowledge of debugging Check Point products.
--Customer oriented and post-sales experience with direct face to face service. Experience with providing training is an advantage.
--Must be able to do 50% travel.
|United States, PA
United States
|Web Site:
|486 Totten Pond Road
Waltham, MA 02451
United States


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Li, Z.Q., Zhang, S., Ma, Y., Luo, J.Y., Wang, C.Y., Lv, L.M., Dong, S.L. and Cui, J.J.
Notes: RNA was isolated from adult C. pallens (insect) tissues using the SV Total RNA Isolation System prior to cDNA library construction and sequencing on the Illumina HiSeq™ platform. To validate NGS sequence alignment, end-to-end PCR was performed. PCR products were purified using the Wizard® SV Gel and PCR Clean-Up System prior to cloning into a T vector. To verify the identified differentially expressed genes, quantitative real-time PCR (RT-qPCR) was used. Total RNA was extracted and cDNAs synthesized using the Reverse Transcription System prior to qPCR. (4560)
Expand Full Notes »
SV Total RNA Isolation Start-Up Kit, 110V Electrical (250 preps, manifold and free vacuum pump)
SV Total RNA Isolation Start-Up Kit, 220V Electrical (250 preps, manifold and free vacuum pump)
SV Total RNA Isolation Start-Up Kit, 100V Electrical (250 preps, manifold and free vacuum pump)
Reverse Transcription System
Wizard® SV Gel and PCR Clean-Up System
Expand Products »
Farkas, T., Fey, B., Keller, G., Martella, V. and Egyed, L.
Notes: Mice RNA samples were converted to cDNA using an oligo-dT primer with the Reverse Transcription System, ethanol precipitated, vacuum dried and transferred to another lab. There they were reconstituted in 20μl of molecular biology grade water.
Detection of caliciviruses in the wild mice samples was attempted using generic calicivirus primers targeting sequences encoding conserved amino acid motifs in the RNA-dependent RNA polymerase (RdRp) region of ORF1. Two microliters of cDNA was used in 25μl PCR reactions using the GoTaq® Green Master Mix. Laboratory mouse RNA samples were tested only with MNV-specific primers in the AccessQuick™ RT-PCR System using 2μl RNA as template.
PCR products were cloned into pGEM-T® Vector and sequenced using M13 forward and reverse primers on an ABI PRISM® 3730 DNA Analyzer. (4330)
AccessQuick™ RT-PCR System
pGEM®-T Vector System I
pGEM®-T Vector System II
GoTaq® Green Master Mix
Ruhlmann, J.M., Kram, B.W. and Carter C.J.
Notes: The authors used microarray analysis to identify genes that are differentially expressed in nectaries of Arabidopsis and may be involved in nectar synthesis and secretion. One of these genes was cell wall invertase 4 (cwinv4). The authors generated two Arabidopsis cwinv4 mutant lines to study gene function and used GoTaq® Green Master Mix to confirm the mutant genotype. Expression patterns of cwinv4 in wildtype Arabidopsis and an ortholog from Brassica rapa were examined in various tissues by RT-PCR. The reverse transcription step was performed using the Reverse Transcription System and 0.1µg of RNA. (4093)
Sal, M.S., Li, C., Motalab, M.A., Shibata, S., Aizawa, S. and Charon, N.W.
Notes: The authors investigated gene transcription within periplasmic flagella of Borrelia burgdorferi, which are composed of a basal body, hook and filament, to determine if hook formation influences flagellin gene expression. They used insertion mutagenesis to construct strains with mutated versions of the hook structural gene flgE that were disrupted by a kanamycin-resistance cassette. The flgE gene and antibiotic-resistance cassette were amplified by PCR and cloned into the pGEM®-T Vector. To assess the effect of flgE disruption on the transcription of filament proteins FlaA and FlaB, quantitative RT-PCR was performed; enolase was used as an internal control. Negative controls without the reverse transcriptase were included for each sample. (3885)
pGEM®-T Easy Vector System I
Staniszewska, I., Sariyer, I.K., Lecht, S., Brown, M.C., Walsh, E.M., Tuszynski, G.P., Safak, M., Lazarovici, P. and Marcinkiewicz, C.
Notes: The authors investigated the ability of α9β1 integrin to act as a neurotrophin receptor and affect cell signaling pathways. As part of the study, RT-PCR was used to detect the presence of other neurotrophin receptors in their model cell line, SW480. Reverse transcription was performed using the Reverse Transcription System and 1µg of total RNA isolated using the SV Total RNA Isolation System. The resulting cDNA (5µg) was amplified for 35 cycles (β-actin as a control) or 40 cycles (TrkA and p75NTR) using GoTaq® Green Master Mix. RT-PCR results were confirmed by Western blot analysis. (3884)
SV Total RNA Isolation System
Leseberg, C.H., Eissler, C.L., Wang, X., Johns, M.A., Duvall, M.R. and Mao, L.
Notes: The authors characterized the network of protein-protein interactions for 22 MADS-domain proteins in tomato using yeast two-hybrid and three-hybrid assays. To construct bait and prey proteins, total RNA from various tissues was reverse transcribed using the Reverse Transcription System, then amplified using PCR primers containing restriction enzyme sites for cloning into the bait and prey vectors. (3886)
Vergnano, A.M., Ferrini, F., Salio, C., Lossi, L., Baratta, M. and Merighi, A.
Notes: The authors investigated the expression pattern of type 1a growth hormone secretagogue receptor (type 1a GHSR), a receptor for ghrelin. In situ RT-PCR was performed on paraformaldehyde-fixed, paraffin-embedded mouse spinal cord tissue. Prior to in situ RT-PCR, tissue sections were treated with proteinase K and triethanolamine, then dewaxed. Reverse transcription was performed using the Reverse Transcription System and oligo (dT)15 primers; followed by amplification using the PCR Master Mix in the presence of 11-digoxygenin-dUTP (1mM). Amplification products were detected using an anti-digoxygenin, alkaline phosphatase-conjugated goat antibody and nitro blue tetrazolium/5-bromo-3-indolylphosphate-p-toluidine salt (NBT/BCIP). (3968)
PCR Master Mix
O'Reilly, K.C., Trent, S., Bailey, S.J. and Lane, M.A.
Notes: The authors examined the regulatory effect of 13-cis-retanoic acid (13-cis-RA) on genes that encode proteins involved in serotonergic neurotransmission in the RN46A-B14 cell line, which was derived from rat embryonic raphe nuclei. Northern blot analysis was performed to quantitate mRNA levels of these genes in 13-cis-RA-treated and untreated cells. cDNA templates for generating Northern blot probes were synthesized by reverse transcription using the Reverse Transcription System followed by PCR. The Reverse Transcription System was also used in RT-PCR to check for the expression of retinoic acid and retinoid X receptors (RAR and RXR, respectively) in RN46A-B14 cells. Briefly, 1µg of total RNA was treated with DNase, reverse transcribed using oligo (dT) primers, then amplified by PCR using RARα, RARβ, RXRα, RXRβ/γ primers. (3790)
Wu, D., Ren, Z., Pae, M., Guo, W., Cui, X., Merrill, A.H. and Meydani, S.N.
Notes: The authors examined the role of ceramide and NF-κB in age-related adipose tissue inflammation in mice. Levels of inflammation-associated molecules, IL-1β, IL-6, TNF-α, COX-2 and peroxisome proliferator-activated receptor (PPAR)-γ mRNA, were quantified by quantitive PCR (qPCR). RNA was isolated from adipose tissues, and first-strand cDNA was synthesized using the Reverse Transcription System prior to qPCR. mRNA levels were also quantified in peritoneal macrophages grown in the presence of young adipocyte-conditioned medium and old adipocyte-conditioned medium. Viability of the primary adipocytes used in these experiments was confirmed using the CellTiter 96® AQueous One Solution Cell Proliferation Assay and CytoTox 96® Non-Radioactive Cytotoxicity Assay. (3777)
CellTiter 96® AQueous One Solution Cell Proliferation Assay
CytoTox 96® Non-Radioactive Cytotoxicity Assay
Curtis, C.D., Likhite, V.S., McLeod, I.X., Yates, J.R. and Nardulli, A.M.
Notes: Tumor metastasis suppressor nonmetastatic protein 23 homologue 1 (NM23-H1) interacts with estrogen receptor α (ERα) and influences ERα-mediated gene expression. The authors knocked down NM23-H1 expression using RNA interference in estrogen-treated or untreated MC-7 human breast cancer cells and determined the effect on transcription of estrogen-responsive genes, including progesterone receptor, Bcl-2, cathepsin D and cyclin D1. Levels of these mRNAs were measured in the presence of NM23-H1 or control small interfering RNAs using quantitative RT-PCR. Total RNA was treated with RQ1 RNase-Free DNase to remove contaminating DNA, and cDNA was synthesized using the Reverse Transcription System. The resulting cDNA was subjected to quantitative PCR using SYBR® Green dye. (3789)
Basgupta, P., Kinkade, R., Joshi, B., DeCook, C., Haura, E. and Chellappan, S.
Notes: RT-PCR was performed to map the subtypes of nicotinic acetylcholine receptors on A549 cells. cDNA was synthesized using the Reverse Transcription System. Northern blotting to assess XIAP and survivin expression was performed, and probes were labeled using the Prime-A-Gene® Labeling System. Apoptosis was assessed in nicotine-stimulated cells using a DeadEnd™ TUNEL Assay. (3382)
DeadEnd™ Colorimetric TUNEL System
DeadEnd™ Fluorometric TUNEL System
Prime-a-Gene® Labeling System
Holzscheiter, L., Biermann, J.C., Kotzsch, M., Prezas P., Farthmann, J., Baretton, G., Luther, T., Tjan-Heijnen, V.C.G., Taliere, M., Schmitt, M., Sweep, F.C.G.J., Span, P.N. and Magdolen, V.
Notes: Few reliable prognostic markers have been developed for breast cancer. Human tissue kallikreins (hKs) are serine proteases with diverse functions. Fifteen human tissue kallikrein genes (KLK) have been identified. Several human tissue kallikreins have been associated with malignancies, such as hK3 (prostate-specific antigen) and prostate cancer. hK7 has been linked to a significantly poorer prognosis for ovarian and breast cancer, indicating that it may serve as a marker for these diseases. However, previous analyses of KLK7 expression were non-selective studies of all KLK7 mRNA forms. The authors developed a quantitative reverse-transcription-PCR (QPCR) assay, using the Reverse Transcription System on RNA, then developed a highly sensitive QPCR assay, to determine whether a more specific analysis of full-length KLK7 mRNA might lead to similar results as those from previous studies on the multiple KLK7 mRNA forms, with the ultimate goal of determining whether KLK7 could serve as a marker for breast cancer. (3615)
Yang, Y.M., Huang, D.Y., Liu, G.F., Zhong, J.C., Du, K., Li, Y.F. and Song. X.H.
Notes: The ability of the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to upregulate cytochrome P450 CYP1A1 levels in mouse liver was examined. Total mouse liver RNA was reverse transcribed using the Reverse Transcription System, and the resulting CYP1A1 cDNA was quantitated using real-time PCR. CYP1A1 protein levels were quantitated by Western blot using an anti-CYP1A1 antibody, the Anti-Rabbit IgG (Fc), Alkaline Phosphatase Conjugate secondary antibody and the Western Blue® Stabilized Substrate for Alkaline Phosphatase. (3443)
Anti-Rabbit IgG (Fc), AP Conjugate
Western Blue® Stabilized Substrate for Alkaline Phosphatase
van de Bovenkamp, M., Groothuis, G.M.M., Draaisma, A.L., Merema, M.T., Bezuijen, J.I., van Gils, M.J., Meijer, D.K.F., Friedman, S.L. and Olinga, P.
Notes: Rat liver slices were used to study hepatic stellate cell (HSC) activation and fibrogenesis. The expression of markers of HSC activation and fibrogenesis were analyzed by real-time PCR. To quantitate mRNA levels, total rat liver RNA was reverse transcribed using the Reverse Transcription System, then amplified in the presence of SYBR® Green. (3430)
McGough, N.N., He, D.Y., Logrip, M.L., Jeanblanc, J., Phamluong, K., Luong, K., Kharazia, V., Janak, P.H. and Ron D.
Notes: The authors examine the role of brain-derived neurotrophic factor (BDNF) in alcohol addition. RNA was isolated from primary rat hippocampal neurons cultured in the absence or presence of ethanol. The RNA was reverse transcribed using the Reverse Transcription System, and BDNF and GPDH RNAs were quantitated by fluorescent real-time PCR. BDNF and nerve growth factor (NGF) protein levels were monitored using the BNDF and NGF Emax® ImmunoAssay Systems. (3441)
BDNF Emax® ImmunoAssay System
Cannady, E.A., Dyer, C.A., Christian, P.J., Sipes, I.G. and Hoyer, P.B.
Notes: These authors characterized cytochrome P450 expression in mouse ovaries treated with the ovotoxin 4-vinylcyclohexene. Total mouse ovary RNA was reverse transcribed using the Reverse Transcription System and random primers, followed by quantitative PCR using primers specific for CYP2E1, 2A and 2B. (3442)
Ekström, P.A.R., Mayer, U., Panjwani, A., Pountney, D., Pizzey, J. and Tonge, D.A.
Notes: RNA was extracted from condition-lesioned and unoperated mouse thoracic dorsal root ganglion neurons, and cDNA was generated using Reverse Transcription System. Additionally, RNA was prepared from cut and unoperated mouse sciatic nerve samples using the SV Total RNA Isolation System. (2662)
Lee, J.M., Shih, A.Y., Murphy, T.H., and Johnson, J.A.
Notes: NF-E2-related factor-2 (NRF2) upregulates transcription of antioxidant response element (ARE)-driven genes. The authors examined the sensitivity of Nrf-2–/– primary mouse neurons to oxidative stress-induced apoptosis using the mitochondrial toxins 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPP+) and rotenone. Primary cultures were >090% neurons, as judged by immunostaining with the Anti-βIII Tubulin mAb and other neuron-specific antibodies. Neuronal cytotoxicity in the presence of MPP+ and rotenone was monitored using the CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay and TUNEL assays. The level of expression of the antioxidant-responsive gene quinone oxidoreductase was measured by mRNA quantitation using RT-PCR, enzyme activity assays and immunocytochemistry. The Reverse Transcription System was used to synthesize cDNA for subsequent amplification by PCR. (3570)
Anti-βIII Tubulin mAb
CellTiter 96® AQueous Non-Radioactive Cell Proliferation Assay
Entin, I., Plotnikov, A., Korenstein, R., Keisari, Y.
Notes: Reverse transcription and PCR was performed on total RNA isolated from spleens of treated mice to determine the effect of treatment on cytokine mRNA expression using the Reverse Transcription System. (2718)
Mahotka, C., Liebmann, J., Wenzel, M., Suschek, C.V., Schmitt, M., Gabbert, H.E., Gerharz, C.D.
Notes: Promega reverse transcription buffer, AMV reverse transcriptase, and RNAsin® RNAse inhibitor were used in reverse transcription reactions of total RNA from HepG2 heptatoma cells. PCR products were cloned into the pGEMT vector. (2613)
AMV Reverse Transcriptase
AMV Reverse Transcriptase (HC)
Reverse Transcription 10X Buffer
RNasin® Ribonuclease Inhibitor
Serafini, B., Columba-Cabezas, S., Di Rosa, F. and Aloisi, F.
Notes: Total RNA was isolated from the CNS, spleen and small intestine of mice with preclinical, acute, remission and relapse EAE with the SV Total RNA Isolation System. The isolated RNA was used to analyze gene expression in each stage using the Reverse Transcriptase System and Taq DNA Polymerase in two step RT-PCR. (2163)
Zhang, J., Ma, B., Marshak-Rothstein, A., Fine, A.
Notes: The Reverse Transcriptase System was used for two step RT-PCR. (0092)
Guo, S., Rena, G., Cichy, S., He, X., Cohen, P., Unterman, T.
Notes: The pALTER®-MAX Vector was used to create mutations causing three separate amino acid substitutions on the FKHR cDNA. The Reverse Transcriptase System was used for RT-PCR. (1088)
pALTER®-MAX Vector
Leiter, H., Mucha, J., Staudacher, E., Grimm, R., Glössl, J. and Altmann, F.
Notes: Total RNA was isolated from 3-day-old mung bean hypocotyls using the SV Total RNA Isolation System. RT for RT-PCR was performed with the Reverse Transcription System. (0825)
Manning, B. M. , Quane, K. A. , Ording, H. , Urwyler, A. , Tegazzin, V. , Lehane, M. , O'Halloran, J. , Hartung, E. , Giblin, L. M. , Lynch, P. J. , Vaughan, P. , Censier, K. , Bendixen, D. , Comi, G. , Heytens, L. , Monsieurs, K. , Fagerlund, T. , Wolz, W. , Heffron, J. J. , Muller, C. R. , McCarthy, T. V.
Notes: First-strand cDNA was synthesized by use of the Reverse Transcription System and random primers. (0728)


text:
And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
The You're Da Bomb note card comes complete with a mushroom cloud and a heart.
Size: A2, 4.25" x 5.5"
Directions: Write, address, stamp, and mail!
This product ships from the maker within 14 days, via USPS
If you're not happy with this item for any reason, you may return it for a full refund within 14 days.


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Friday facts: The Affordable Care Act and young Americans
Two years ago this month, President Obama signed the Affordable Care Act into law—a major reform that has already made health insurance accessible to millions of Americans. This week's Friday Facts takes a look at how the Affordable Care Act has helped give more young adults access to the coverage they need.
Here's more on how the President's health care law is making a difference for young people:
14.1 million: Children who received expanded coverage of preventive services, like well-child visits and flu shots, under the Affordable Care Act in 2011
Up to 17 million: Children with pre-existing conditions who cannot be denied health insurance. Before the Affordable Care Act, insurance companies could deny coverage to kids with medical conditions


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Comedian Amy Phillips Does a Dead-On Vicki Gunvalson From 'RHOC' [VIDEO]
The 'Real Housewives' franchise on Bravo TV is my guilty pleasure. I know it's terrible, I know it's fake, but I just can't help it. I love them. Well, here comedian Amy Phillips impersonates Vicki Gunvalson from 'The Real Housewives of Orange County' to a "T!"


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Ethan Hawke and Julie Delpy in Richard Linklater's Before Midnight
Sundance Film Festival 2013 Predictions
Although the Sundance Film Festival won't take place for another two months, you can expect to hear the first selections for the 2013 festival within the next couple of weeks. In anticipation of this announcement, IONCinema has made a few guesses as to what might be included. This past year, as with many other years, some of the most talked-about films of the year such as Beasts of the Southern Wild and recently released The Comedy made their debuts at the legendary indie-centric festival in Park City, Utah. Among their predictions are Ain't Them Bodies Saints, David Lowery's directorial debut starring Casey Affleck, and Richard Linklater's much-anticipated Before Midnight.
Sharon Lockhart at The Jewish Museum
The Jewish Museum recently unveiled an exhibit from the mind of Los Angeles-based artist Sharon Lockhart, who blends her own photography and films with the work of Israeli dance composer and textile artist Noa Eshkol. The centerpiece of the exhibit is Five Dances and Nine Wall Carpets by Noa Eshkol, which is described as a "large-scale film installation that features a selection of Eshkol's dances, performed with nine of her textile works." The Film Society of Lincoln Center will partner with The Jewish Museum in January for the 22nd annual Jewish Film Festival.
Paul Thomas Anderson's The Master
Steadicam in the Films of Paul Thomas Anderson
The British Film Institute's website has a treat for all film fans: a fascinating video essay on the use of mobile camerawork throughout Paul Thomas Anderson's films. In closely analyzing Anderson's work, Kevin B. Lee unlocks patterns and stylistic evolutions over the course of his career. Beginning with Hard Eight, Lee evidences Anderson's growing distance from the flashy, self-reflexive style of his earlier work to his much more restrained films of recent years. A must-read/see!
The Eye of the Tiger
Along with its use of 3D cinematography, NYFF50 Opening Night Selection Life of Pi pushed the boundaries of cinema with its use of computer-generated imagery, or CGI. In a recently published article, Mekado Murphy of The New York Times dug into the overwhelmingly complex process of digitally creating a tiger that would be in almost every scene of Ang Lee's stunning new film. Hundreds of artists were assigned to work on the tiger, with specific groups meant to take on certain layers of the tiger. As Murphy writes, they "started with the skeleton, which they used to control basic movements… then added muscle, skin and fur." The article is accompanied by a slideshow tracking the tiger's digital creation.


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SAN JOSE — Police continue their search for suspects in the deadly daylight downtown shooting of a 22-year-old San Jose man, which may have stemmed from an earlier clash at nearby St. James Park.
Police and relatives confirmed that Ramon Garcia, 22, was the victim of the Saturday afternoon attack. A surveillance camera near North Fourth and East Julian streets recorded the shooting that occurred about 1 p.m.
In the video, Garcia is being chased by an unidentified man into the parking lot behind Tico's Tacos restaurant, and the assailant appears to fire a gun at him before running away. Moments later, another man, riding a bicycle, rolls up to the wounded victim and appears to also shoot at him.
However, investigators are only confirming the first instance of gunfire, which was marked by a clearly visible muzzle flash in the footage.
"The visual evidence doesn't seem to confirm (the second)," said Officer Albert Morales, a police spokesman. "Everything points to one person and one person only. We don't see two shooters."
Garcia was taken to the Regional Medical Center, where he was pronounced dead. Relatives said he was the father of five children and was expecting a sixth.
Police say Garcia had gotten into an argument at nearby St. James Park before he was shot.
"There was an altercation prior to the shooting that started at the park. We're still trying to confirm how many people there were," Morales said.
He added that there was not enough evidence to say whether the shooting was gang related.
The death marked the city's 33rd homicide of the year. San Jose is on pace to surpass last year's homicide tally of 46, which was a two-decade high.
Anyone with information about the case can contact San Jose homicide detectives at 408-277-5283 or leave a tip with Silicon Valley Crime Stoppers at 408-947-STOP (7867) or with svcrimestoppers.org.
Contact Robert Salonga at 408-920-5002. Follow him at Twitter.com/robertsalonga.


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Draper BARONET 84IN X 84IN AV HIGH CONTRAST G (129069)Item#: 40170833 | Model#: 129069
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Filter Forge is – by quite a margin – the most powerful plug-in we've looked at here. That's because it's a tool for creating plug-ins, both generative texture-creation tools and effect filters.
Neil Bennett
Digital Arts
Get a personal discount on
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"I'm thinking Filter Forge should come with a warning: 'This Product could be Habit Forming'."
Nancy Schober
"Incredibly powerful texture engine."
Albert Kiefer


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Movie Figure Shows Off The Newest Spidey Suit...
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, RedfordFilms.com, Toynk.com, PastGenerationToys.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.
Hot Toys reveals their latest 1:6th scale action figure: Spider-Man from the upcoming Marvel motion picture The Amazing Spider-Man. The film-accurate Spider-Man collectible is specially crafted based on the image of Andrew Garfield as Spider-Man/ Peter Parker in the movie, highlighting a newly developed head sculpt, highly detailed costume and accessories.
The 1:6th scale Spider-Man action figure - slated for release 4th Quarter 2012 - features:
- Authentic and detailed fully realized likeness of Andrew Garfield as Spider-Man/ Peter Parker in the movie
- Two (2) heads, including head sculpt of Peter Parker and Spider-Man
- TrueType body with 30 points of articulation
- Five (5) pairs of interchangeable palms with silvery cobweb pattern including:
. One (1) pair of relaxed palms
. One (1) pair of fists
. One (1) pair of palms for cobweb shooting
. One (1) pair of palms for cobweb swinging
. One (1) pair of palms for climbing
Costume :
- One (1) red- and blue-color Spider-Man suit embossed with black cobweb pattern with dark blue spider icon on chest
- One (1) pair of red-color boots embossed with black cobweb pattern
- Four (4) long narrow strips of cobweb including:
. Two (2) for imitating the flying scene
. Two (2) of cobweb shooting
- Figurine stand with Spider-Man nameplate and the movie logo
- Head Sculpted by Im Jung Hyuk
- Head Painted by JC.Hong
- Head Art Directed by Kim Kyung Ah
- Costume Designed by Hai Lim
** Prototype shown is not final, pending licensor approval


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By Varietal
Intro: This burger was inspired by my love for the traditional field greens salad with fruits and nuts. In my opinion, the only thing missing was a juicy burger and toasted roll.
My husband and I enjoy grilling burgers often and were tired of the same old thing. In an attempt to "spice up" our dinner time I began to experiment with various meats and ingredients.
This burger is designed after the classic Ceasar salad. The burger contains, and is topped with ceasar dressing.
Hello, my name is Billy. I'm 27 years old.
It may look like a lot of ingredients are in this burger, but many of the ingredients are duplicates that tie together all the flavors of this burger.
This tasty burger is inspired by a crisp and flavorful French autumn salad I still crave from my time as an exchange student in high school.
I love Brie. I love hamburgers. I saw the contest advertised in Sunset Magazine and knew I wanted to do a burger incorporating Brie.
As Americans discover the regional food craze, I can't get much closer to home than my kitchen and herb gardens. Both gardens are directly off my kitchen, accessible through French doors.
i had a turkey burger from a local restaurant with roasted red peppers on it. it was delicious.
Caesar Cardini, an Italian immigrant, created the Caesar Salad on July 4, 1924.
A local restaurant serves the most amazing grilled chicken spiedini. I thought a ground chicken version would lend itself very well as a burger. I think you will agree, it's delicious.
I had an appetizer with similar ingredients and thought it would make a terrific burger!
I developed this recipe from a dinner entree and side dish. I love the combination of it all.
i have been working on a chicken burger with some zing...not from habaneros but via thai/indian spices..so thru experimenting with varying amounts of certain ingredients i have found our family win


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68S — By Alan Harper —
September 2004
It's Hip to be Square
Azimut re-enters the express market with a strikingly different 68-footer.
Okay, let's talk about those windows first—the square ones in the topsides. They're real, and they work: You can actually see out of them. They're clever, too, because while the area of each panel is relatively small, arranging them in a tight three-by-three rectangle actually fools the eye into seeing them as one big picture window with a view. They make quite an impression. Looking out from the owner's amidships stateroom, you feel you're part of the seascape.
They also create an utterly distinctive external signature for the Azimut 68S, and for this builder that was almost more important than giving the owner a nice view. Azimut, after all, doesn't want you to forget that it was the one to come up with the idea of topside windows in the first place, in its 68 Plus flying-bridge cruiser a few years ago. Far from being flattered that virtually every other boatbuilder in the world now has its own variation on this excellent theme, the Italian yard is actually rather miffed at being copied. So the square windows in the 68S are a challenge: Copy these, if you dare.
Of course, this may not be the most tactful moment to consider the design relationship between those flat, eye-shape wheelhouse side windows and the curved windshield (a stylistic theme pioneered by Pershing) or the 68S's clever electro-hydraulic bathing platform, which slides down into the water (like the Sealine S48's), or even the circular "beam me up" shower stalls, which are now used by nearly everyone but were originally thought up by Ferretti. Instead, let's look at some of the other great ideas to be found in this boat. There are lots of them.
Take the sunroof, for example. The 68S may be technically a hardtop, but you wouldn't necessarily know it, because an enormous area of roof slides away to open up some 65 square feet of sky—an effect that has been achieved by simply dividing the sliding section into folding panels that stack, accordion-style, and tuck in neatly behind that spaceship radar arch.
Then there are the high-tech flourishes that Azimut prides itself on, particularly the maneuvering and mooring technology. Computer-controlled joysticks that interface thrusters with main engines have been around for a few years now, but to find such a system in a boat this size, even as an option, is still a rarity. And that's not all: There are two acoustic mooring sensors mounted on both the swim platform and the taffrail to cope with different heights of seawall, giving the helmsman an audible proximity warning when mooring stern-to. Then there are the automatic engine room vent flaps in the hull sides that pop open when the revs exceed 1200 rpm for more than 20 seconds. When it comes to gizmos, this boat is loaded.
And in a way, she has to be. This 68S is Azimut's first new express in more than 20 years. Although a dominant force in flying-bridge motoryachts, the company nevertheless knew it would be regarded as a newcomer in the competitive sport-yacht sector and realized it had to produce something dramatic: a boat that would not only perform and function properly but also command attention.
So there are clever new ideas in the accommodation layout, too, one of which hits you as soon as you step aboard. The galley is down on the lower deck, on the starboard side, but separated from the main companionway and central corridor by a longitudinal bulkhead and open to the sky along much of its length. You could criticize it for size, but it definitely works.
Next page > Part 2: Azimut's designers were able to start the 68S with a clean sheet of paper. > Page 1, 2, 3, 4, 5
This article originally appeared in the August 2004 issue of Power & Motoryacht magazine.


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Cup of CoffeeScience brain teasers require understanding of the physical or biological world and the laws that govern it.
You are served a hot cup of coffee and room-temperature cream at a restaurant. You want to wait a few minutes before you drink the coffee, and you want it to be as hot as possible when you drink it. Should you pour the cream in the coffee:
a) Immediately
b) Just before you drink it
c) It doesn't matter
( "don't add any cream" is not an option)
AnswerThe driving force for heat transfer is temperature difference. The coffee by itself is very hot and will therefore cool down at a fast rate. Then once the cream is added the temperature will drop even more. If the cream is added immediately, then the temperature will drop initially but will then drop at a slower rate since the coffee with cream is cooler than the coffee alone and therefore the driving force for heat transfer is less.
As an added bonus, adding the cream will increase the mass of the contents of the cup. A larger mass takes longer to cool down than a smaller one at the same temperature.
Therefore, the cream should be added immediately.
What Next?
See another brain teaser just like this one...
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"Brimming with ideas and a fascinating read."
–STEVEN PINKER, Johnstone Professor of Psychology, Harvard University
"Likely the most important contribution to the concept of ancestral health since The Paleolithic Prescription."
–ROBB WOLF, bestselling author of The Paleo Solution
"The new common sense."
–MARK SISSON, author of The Primal Blueprint and publisher of MarksDailyApple.com
"The definitive guide to going paleo."
–JOSHUA NEWMAN, founder of CrossFit NYC
"Read this book as a hardcover, e-book, or stone tablet, but read it."
–A.J. JACOBS, Editor at large at Esquire magazine
"Insightful and inspirational...a masterpiece."
–ERWAN LE CORRE, founder of MovNat
"Biohackers willlove it."
–PATRICK VLASKOVITS, founder of PaleoHacks.com and NYT bestselling author
"A first glimpse of a new and better world."
–SETH ROBERTS, Emeritus Professor of Psychology, UC Berkeley
"Splendid...essential reading."
–BAREFOOT TED MCDONALD, ultrarunner and founder of Luna Sandals
"Deeply radical and utterly sensible."
–EMILY DEANS, M.D., Harvard Medical School
Buy Now
Posted by John on April 21st, 2012 | 6 Comments
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Thanks to Malice for the link.
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John Durant is author of The Paleo Manifesto and founder of Wild Ventures. He has been featured in the New York Times, The New Yorker, NPR, and interviewed on Colbert.
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As far as food goes, the Whisman area of North Mountain View is no Castro Street, and certainly no Google. There's nothing cool about it. Roger's attracts a multicultural clientele of soldiers from Moffett Field, scruffy tech workers from nearby office parks, elderly and very young neighbors. Strollers and walkers are easy to maneuver around the fleet of outdoor tables, shaded by umbrellas or overhangs. Indoor seats are not uncomfortable.
Open from the crack of dawn to just before dinner, Roger's serves up quality, value and an all-around pleasant experience. People who work there evidently care about they're doing.
At a busy lunch hour, all the counter staff were friendly and efficient. My companion asked about water, because the dispenser was empty, and within minutes it was replaced.
Breakfast starts at 5 a.m. on weekdays, 6 a.m. on weekends, and goes all day. If you want breakfast just before dinner, this is the place to go. The one tricky thing is that there's a separate line, marked by a small sign: "Please order bagel, croissant sandwich, omelette here." A cheese omelet is $5.50, blueberry pancakes are $6.25.
Instead of microwaving, which turns bread products to mush, at Roger's they toast sandwiches to order. A breakfast croissant is hot and flaky, with crispy edges. And cheap: scrambled egg, avocado and the melted cheese of your choice on a house-baked croissant: $3.95.
Rolls and breads are baked daily, as are the donuts ($1 each, $10 a dozen) at Roger's Deli & Donuts. Tracy Lam inherited the name from the previous owner back in 1995. A menu still lists sandwiches as Roger's Favorites, whoever Roger was.
The homemade meatball sandwich on an asiago roll ($6.20) was bland but generous. More of the fresh tomato sauce would have done the trick. Regulars ordered lots of tuna, turkey, Reuben and salami sandwiches. Build your own submarine sandwich on rolls ranging from Dutch crunch to poppy seed to sourdough, plus seven choices of cheese.
Vegetarians find lots of options, including a garden burger and a veggie sandwich.
As with the rest of the menu, drinks are large, varied, and reasonably priced. A 12-ounce fountain soda is 89 cents. Roger's also has espresso drinks, Thai iced tea and iced coffee, and a huge cold case of juices and other beverages.
Does Roger's do everything well? Maybe not everything. But the food is fresh, and the place is run by a real person, not a marketing plan. It's been working well, going on 19 years.
Roger's Deli & Donuts
295 E. Middlefield Road, Mountain View
Hours: 5 a.m.-6 p.m. Mon.-Fri.; 5 a.m.-5 p.m. Sat.; 6 a.m.-4 p.m. Sun.
Reservations: no
Credit cards: yes
Parking: adjacent lot
Alcohol: no
Highchairs: yes
Outdoor dining: yes
Party and banquet facilities: no
Catering: yes
Takeout: yes
Noise level: fine
Bathroom cleanliness: fair


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Tempe police: Elimination of frat row has caused problems, violencePosted: Updated:
Missing ASU student Jack Culolias was in the process of joining a fraternity when he disappeared. Although it has not been confirmed whether his disappearance is connected to the fraternity, it is just one of several recent incidents that have some questioning whether Greek life at ASU is out of control.
This is the first full semester since the fraternity houses on campus have been eliminated. What was known as "fraternity row" has been leveled. So fraternities are taking over huge houses and apartment complexes in Tempe neighborhoods, and that has taxed police resources, has residents complaining and has been proving dangerous to the students.
An apartment complex east of ASU's campus has been taken over by the Delta Kappa Epsilon fraternity, and it was there at 4 a.m. the Sunday before Thanksgiving that one of its members was attacked.
"It was a very violent attack on that individual," said Tempe Assistant Police Chief Angel Carbajal.
Surveillance cameras captured it all. In it, you can see 15 to 20 guys approach three DKE members. Two of the three targeted ran, leaving Lyle Blumears.
According to the police report, Blumears suffered a broken jaw, concussion and split lip requiring stitches. After the initial attack, a couple of suspects pinned Blumears against the wall while at least four others let loose.
"We've made two arrests, and the investigation is continuing at this point," Carbajal said.
Police arrested Nicholas Haffner and Jon Kuespert and identified them and their friends as current or former members of Tau Kappa Epsilon - a rival fraternity that occupies the complex right next to the DKE's.
"We've seen an increase in calls for service related to fraternities in our neighborhoods," Carbajal said.
Police records show Tempe police responded to known fraternity addresses more than 150 times since August. Many say the demolition of frat houses on campus pushed the problems associated with fraternities into the neighborhoods.
"We've received a lot more complaints from residents than we have in the past, we've received a lot more complaints from our officers than we have in the past in terms of dealing with that issue," Carbajal said.
This is a hot topic in Tempe right now; it is being discussed by the mayor, council, police and ASU officials.
Delta Kappa Epsilon sent a statement saying:
"Recently unknown individuals vandalized the property where a number of our members live and also assaulted a member of our fraternity. The majority of our fraternity members were out of town at a retreat in Northern Arizona at the time except for a few members who had work or school obligations. Members of Delta Kappa Epsilon have been cooperating with Arizona State University and Tempe police to solve this matter in a timely fashion. Surveillance footage, statements from members and other assistance has been provided to officials freely during the investigation. We have the utmost confidence in the ASU judicial process and civil legal system. It is our hope that the ongoing investigations will be completed quickly and that the perpetrators will be brought to justice. Inter-fraternal violence has no part in the Greek system at ASU or anywhere, and DKE has always strived to be a leader in taking steps to improve the sense of harmony and community among our Greek organizations, efforts which we will continue to pursue. We appreciate all the support that the fraternity and our injured member has received since the incident."
"Separately, DKE wishes to extend our sincere best wishes to the family of our inter-fraternal Brother Jack Culolias. The Brothers of DKE hope and pray for his safe return, and we offer any help to the family that they might need."
Arizona State University sent a statement saying:
"Arizona State University is strongly committed to a thriving and robust Greek system. We believe that a campus residential component is important to the success of our fraternities and sororities, as well as the individual student members. The recently eliminated houses on Alpha Drive were in severe disrepair - e.g. buildings not up to code - and were not only terrible learning environments but threatened the health and safety of the small number of students who resided there. ASU has 54 Greek organizations that include 4,000 students, and it should be noted that only a fraction of each resided on Alpha Drive. The university has always offered fraternities and sororities the opportunity to live on campus and many do live in residence halls, including 12 sororities that comprise Aldelphi Commons. These chapters are healthy and thriving. We are currently engaging students in planning for a new on-campus residential component for all chapters, including those that are currently on campus and those that have chosen to live off campus. The Greek community, including alumni, have been supportive of the plan. While still in the planning phase, the Greek community will include living, meeting and social gathering spaces for the chapters. We envision chapter suites that will comprise a new Greek residential complex."
"The university does act on off-campus student misbehavior and students are subject to the Student Code of Conduct."
"ASU works closely with the City of Tempe on many issues, including those involving our students. We strive to seek a positive resolution on these issues. The ASU Police Department works in conjunction with the Tempe Police Department on many joint endeavors, including any fraternity complaints."
Delta Kappa Epsilon (DKE) has never lived on Alpha Drive. Tau Kappa Epsilon
(TKE) has not lived on Alpha Drive since the 2005-06 academic year.
Additionally, we have no records indicating that these two organizations have a history of any negative behavior between them. After the incident was reported, both chapters were placed on interim suspension and the incident is currently under investigation. No information has been given to suggest this incident was racially motivated."
Copyright 2012 CBS 5 (Meredith Corporation). All rights reserved.


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Our pick of the week's science and technology stories include Facebook and Google's new search, a new look at Stephen Hawking and how to protect workers from the rise of robots.
Facebook's bold, compelling and scary engine of discovery: The inside story of Graph Search
Steven Levy | Wired | 15 January 2013
As the title suggests, this is an in-depth look at the story behind Facebook's much-anticipated search product. "A transformative product gets you to do more of something that you wouldn't think to do on your own. Thanks to Graph Search, people will almost certainly use Facebook in entirely new ways. it expands Facebook's core mission – not just obsessively connecting users with people they already know, but becoming a vehicle of discovery".
How to protect workers from the rise of robots
Noah Smith | Atlantic | 14 January 2013
The coming of intelligent robots will change the historic relationship between labour and capital in a way that previous technologies did not. Value of labour will collapse. How best to distribute income and wealth fairly? By making all of us entrepreneurs – so we all have our own robots.
The Panasonic Toughpad press conference
Grant Howitt | Look Robot | 14 January 2013
Writing degree zero. What it feels like to cover a tech industry press conference when you don't actually know anything about the tech industry, and in any case you have a hangover. As for the product: "It is a tablet computer you can drop underwater from a height and have that not be a problem".
The searchers
Nicholas Carr | Rough Type | 13 January 2013
Short reflection on Google's "personalised" search. "In its new design, Google's search engine gives us information that fits the behaviour, needs and biases we have displayed in the past. It reinforces the existing state of the self rather than challenging it. It subverts the act of searching"
Has the ideas machine broken down?
Anonymous | Economist | 11 January 2013
This modern age is great at producing incrementally jazzier gadgets. But we've lost the vision, the appetite for fundamental technological progress. Revolutions in transport, health science, even kitchen gadgetry all took place before 1970. Since then we've done the internet and that's all.
The placebo phenomenon
Cara Feinberg | Harvard Magazine | 10 January 2013
Profile of Ted Kaptchuk, researcher into placebos and their effects. His findings: People respond positively to placebos even when they know that the placebos are placebos; and, the effect is dose-dependent. More medicine makes you feel better even when it's fake medicine.
On Stephen Hawking, Vader, and being more machine than human
Helene Mialet | Wired | 8 January 2013
When we celebrate Hawking, who and what are we really celebrating: the man, the mind, or the machines? "Hawking isn't just issuing remote commands and expressed desires, his entire body and even his entire identity have become the property of a collective human-machine network. He is what I call a distributed centred-subject: a brain in a vat, living through the world outside the vat".
The Dunbar Number, From the guru of social networks
Drake Bennett | Business Week | 10 January 2013
Profile of Robin Dunbar, deviser of the much-debated Dunbar Number, which holds that for most human activities – forming tribes, making friends, sending Christmas cards, using Facebook – the largest manageable in-group is 150 people. He argues it's a function of brain size. The smaller the brain, the smaller the number.
For more articles worth reading, visit The Browser. If you would like to comment on this article or anything else you have seen on Future, head over to our Facebook page or message us on Twitter.


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Android Users - Coming Soon! - Migrating from aCar 4.8 to 5.0
Real Name: A D Joined: September 2011
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SmartPhone m.fuelly.com
You can save a bookmark on your smartphone.
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by tommyz
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© 2017 Fuelly.com - All Rights Reserved. Sep 20, 2017 6:18 AM CDT
A simple & effecive way to track fuel consumption
Easy to understand the real cost of your vehicle


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Adamina Canvas Tote Bags are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Adamina Canvas Tote Bag for a special occasion, give a Adamina Tote Bag as a present or need to represent with a funny Custom Adamina Bag during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Adamina Canvas Tote Bag for you! Even if it turns out you can't find the right Custom Adamina Bag with the perfect design for your mother, father or children (or friends!); Idakoos offers all of its Adamina Canvas Tote Bags as Custom Adamina Tote Bags. Personalize any Adamina Canvas Tote Bag the way you want to ensure the perfect gift.
Showing 1 - 24 of 73 Canvas Tote Bag


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Cardinal Health is the global leader in providing outsourced pharmaceutical development services, drug delivery technologies, contract manufacturing, packaging and product commercialization services, serving the worldwide pharmaceutical and biotechnology industries. With proven expertise and a long history of innovation, Cardinal Health helps its customers accelerate their development process, streamline their supply chain, and extend the life of their products. Cardinal Health also offers the broadest range of dose form development and manufacturing options in the industry--from traditional and proprietary oral forms to sterile products, from inhaled forms to topicals.
Development:Cardinal Health offers a range of services, such as pre-clinical support, API development, analytical services, drug delivery development, clinical manufacturing and packaging services. We have expertise in inhalation development, and can offer innovative cell-line development using our proprietary GPEx™ technology.Consulting:We provide a wide range of scientific and regulatory consulting services required to obtain marketing approval for drugs, biologics and medical devices in the U.S., Canadian, Asian and European markets.Drug Delivery:Cardinal Health holds more than 1,500 patents and patent applications for drug delivery systems. Our drug delivery technologies include soft gelatin capsules, Zydis® fast dissolve dosage form; EnCirc®, EnVel®, and EnSolv® for oral modified release products; lyophilization; inhaled technologies (MDI, DPI, nasal sprays); and topical Microsponge® for timed release and DelPouch® for unit dosing.Manufacturing:We provide manufacturing for nearly every dose form on the market today. Along with our proprietary dose forms, we also manufacture traditional oral dose forms (tablets, capsules,liquids), sterile dose forms (lyophilization, fill/finish manufacture in vials, ampoules, prefilled syringes, and our innovative "Blow/Fill/Seal" aseptic technology), and topical and inhaled forms. We also produce biologics for pre-clinical and clinical studies, and both clinical and commercial radiopharmaceuticals. We can also help improve yields in commercial biologics production using our proprietary GPEx® technology.Packaging:Cardinal Health helps pharmaceutical and biotech companies build strong brand franchises by designing unique packaging solutions that create shelf presence and improve patient compliance. From cartons to promotional materials to printed inserts and labels, we offer expertise and attention to detail.
Toll Free Numbers
North America: 1-866-720-3148
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E-Mail: firstname.lastname@example.com
Web site: www.cardinal.com/pts
Last Updated: 06-22-2006


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Still finalizing your New Year's resolution? You're not alone. Besides, chances are good that you will break your resolution shortly after you decide on one. But there will be some success stories, both individually and collectively.
Along those lines, here is a suggested 2013 resolution for each MLB team (listed in the order of finish from last season—with the exception of the Houston Astros, who go from last place in the NL Central to last place in the AL West):
New York Yankees: To lock Mariano Rivera in the bullpen during batting practice.
Baltimore Orioles: To force every game into extra innings.
Tampa Bay Rays: To allow well-read manager Joe Maddon to pencil in treasured literary phrases in newcomer Yunel Escobar's eye black.
Toronto Blue Jays: To hire a personal trainer for every player on the 40-man roster, as injuries might be the biggest threat to their first postseason appearance in 20 years.
Boston Red Sox: To expand the clubhouse ban on beer to include Groucho Marx disguises.
Good riddance, 2012: Bad year for Valentine, others in MLB
Detroit Tigers: To start Avisail Garcia at third base just once, just to see if anyone would notice.
Chicago White Sox: To do whatever is necessary to ease the concerns of fans who aren't sold on replacing the notorious A.J. Pierzynski with a player whose last name is Flowers.
Kansas City Royals: To avoid another season-killing 0-10 start at home, even if it means using James Shields on short rest in April.
Cleveland Indians: To invest in plenty of pie tins, in hopes that newcomer Nick Swisher will have ample opportunities to use them.
Minnesota Twins: To put an immediate halt to their ill-conceived strategy of trading every center fielder in their organization (see: Denard Span, Ben Revere).
Oakland Athletics: To seek help (ideally in the form of a trading partner) for their addiction to hoarding center fielders.
Texas Rangers: To somehow convince their fans that the past three months actually were part of a horrible dream. (Hey, it worked on that "Dallas" show).
Los Angeles Angels: To secretly instruct Mike Trout and Peter Bourjos to catch every ball hit to the outfield.
Seattle Mariners: To continue to express their appreciation that the Astros are now division rivals.
Houston Astros: To apologize again for prematurely revealing their new uniforms and logo online, as well as leaking the fact that they will finish last in the division.
Washington Nationals: To announce during Day 1 of spring training that Stephen Strasburg is on a 200-inning minimum.
Atlanta Braves: To extend the infield dirt all the way to the warning track, as the umpires already believe that to be the case.
Philadelphia Phillies: To replace the jersey numbers of Domonic Brown and Darin Ruf with question marks, at the overwhelming request of the fan base.
New York Mets: To teach Johan Santana to throw a knuckleball.
Miami Marlins: To post all of Logan Morrison's tweets (@LoMoMarlins) on the video board during games, as they are exponentially more entertaining than the on-field product will be.
Cincinnati Reds: To bring in the center field wall 50 feet if the Shin-Soo Choo experiment gets off to a rocky start.
St. Louis Cardinals: To continue to maintain a shroud of secrecy as to the location of the plant where they manufacture all of those 100-mph-throwing relievers.
Milwaukee Brewers: To allow Nats racing mascot Teddy to try to extend his newfound success in the Presidents Race to the Sausage Race (but only if it has no bearing on the playoff race).
Pittsburgh Pirates: To acquire a legitimate bat prior to the trading deadline, ending their two-season string of second-half fades and their two-decade string of sub-.500 seasons. Seriously.
Chicago Cubs: To continually preach patience during the rebuild, then throw $52 million at a career sub-.500 starting pitcher. Oh wait, they actually are ahead of schedule.
San Francisco Giants: To gently inform fans that Marco Scutaro will not bat .500 with 50 walkoff hits during the regular season.
Los Angeles Dodgers: To resist the urge to acquire every opposing player in the division, thus ensuring their first NL West title since 2009.
Arizona Diamondbacks: To put Justin Upton on the trading block, then claim he likely will remain with the club. And then repeat the process infinitely, as has been the case the past couple years.
San Diego Padres: To sign Chase Headley to an extension, ending speculation that he will be traded and proving that the new ownership group is committed to winning. Seriously.
Colorado Rockies: To experiment with the idea of a nine-man rotation in which each starter throws one inning per day, every day.


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WASHINGTON — A group representing the nation's pharmacy benefit managers said Health and Human Services secretary Kathleen Sebelius should continue encouraging state Medicaid programs to explore affordable pharmacy solutions despite opposition from the independent drug store lobby.
The Pharmaceutical Care Management Association said the current "old-school, fee-for-service" approach used by state Medicaid programs "exposes state governments to political pressure from the independent drug store lobby to set artificially high payment levels," arguing that the focus is on profits instead of patients.
"Medicaid can no longer afford to spend more on pharmacy benefits than Medicare and commercial payers. States should have the flexibility to use the tools other programs use to reduce costs," said PCMA president and CEO Mark Merritt. "State Medicaid programs can no longer afford to pay pharmacies double or triple what other programs pay."
The statement from the PCMA followed a document released last week by Sebelius, who urged all 50 state governors to find ways to cut costs through various approaches.


text: At BJJ Sports we aim to make the Jiu Jitsu Gi buying process simple and informative. Check out our Jiu Jitsu Gi Buyer's Guide for help on choosing your BJJ Gi. We carry a variety of different colors and weaves - anything from ultra light gis to heavy double weave gis. If you are looking for No-Gi Jiu Jitsu gear, check out our Fight Wear section for Fight Shorts and Rash Guards.


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Buyer's Guide: Real-Deal Mad Men Vintage
Threads from the early sixties abound — you just have to know where to look.By Ashley Hoffman
Threads from the early sixties abound — you just have to know where to look.By Ashley Hoffman
HGTV Is a Never-ending Fantasy Loop. Look Deeper, and It Gets Pretty Ugly.
Jennifer Lawrence Sounds Like a Horrible Person to Be Stuck on a Plane With
The Story Behind the Greatest Internet Recipe Comment of All Time
Kirsten Dunst Accidentally Got Stoned Out of Her Mind on Some 'Strong Sh*t' While Filming Her New Movie
John Kelly Suffers Through Donald Trump's U.N. Speech
How Does the New It Movie Deal With Stephen King's Orgy Scene?
This Stanford Professor Has a Theory on Why 2017 Is Filled With Jerks
Every Emma Stone Performance, Ranked
Senate Republicans Are Abdicating Their Governing Responsibility
How the Laura Palmer House's Actual Homeowner Ended Up in Twin Peaks: The Return's Final Scene


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Posted 7 years ago
(1 item)
I got this pen today at an estate sale and am trying to identify it and figure out how much it is worth. At the sale there was a lot of World War II items. I'm thinking it might be an officers pen from World War II, I am not sure. On the pen it says " 1/20 10kt Cross Made In USA" There is one diamond between two red rubys on the gold plate attached to the pen and there is also some type of bird above them.


text: Hi, I'm new and this is my 1st post. I was diagnosed with SLE about a year ago and have been on plaquenil and prednisone tapers. Now rhumatologist wants me to try Methotrexate since my joint pain has worsened. With reluctance I will try it. I'm sure like others, I hope for something to happen positively...like remission! Any comments about the "start up" side effects and on-going use of this med would be beneficial to hear.


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Test Overview
A brain natriuretic peptide (BNP) test measures the amount of the BNP hormone in your blood. BNP is made by your heart and shows how well your heart is working. Normally, only a low amount of BNP is found in your blood. But if your heart has to work harder than usual over a long period of time, such as from heart failure, the heart releases more BNP, increasing the blood level of BNP. The BNP level may drop when treatment for heart failure is working.
Why It Is Done
The brain natriuretic peptide (BNP) test is used to:
- Check for heart failure. A doctor may think you have heart failure if you are having problems such as trouble breathing and swelling (edema) in the arms or legs.
- Find out how severe heart failure is.
- Check the response to treatment for heart failure.
How To Prepare
You may be asked to not eat or drink anything except water for 8 to 12 hours before having a BNP test.
Your doctor may tell you to stop taking certain heart medicines before this test. Follow your doctor's instructions exactly.
Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results will mean. To help you understand the importance of this test, fill out the medical test information form(What is a PDF document?).
How It Is Done
The health professional drawing your blood will:
- Wrap an elastic band around your upper arm to stop the flow of blood. This makes the veins below the band larger so it is easier to put a needle into the vein.
- Clean the needle site with alcohol.
- Put the needle into the vein. More than one needle stick may be needed.
- Attach a tube to the needle to fill it with blood.
- Remove the band from your arm when enough blood is collected.
- Apply a gauze pad or cotton ball over the needle site as the needle is removed.
- Apply pressure to the site and then a bandage.
How It Feels
You may feel nothing at all from the needle puncture, or you may feel a brief sting or pinch as the needle goes through the skin. Some people feel a stinging pain while the needle is in the vein. But many people do not feel any pain (or have only minor discomfort) once the needle is positioned in the vein. The amount of pain you feel depends on the skill of the health professional drawing the blood, the condition of your veins, and your sensitivity to pain.
There is very little risk of complications from having blood drawn from a vein.
- You may develop a small bruise at the puncture site. You can reduce the risk of bruising by keeping pressure on the site for several minutes after the needle is withdrawn.
- In rare cases, the vein may become inflamed after the blood sample is taken. This condition is called phlebitis and is usually treated with a warm compress applied several times daily.
- Continued bleeding can be a problem for people with bleeding disorders. Aspirin, warfarin (Coumadin), and other blood-thinning medicines can also make bleeding more likely. If you have bleeding or clotting problems, or if you take blood-thinning medicines, tell your health professional before your blood is drawn.
A brain natriuretic peptide (BNP) test measures the amount of the BNP hormone in the blood.
Normal BNP values are higher in women than in men. BNP values normally increase with age but may stay within a normal range unless heart failure is present.
The normal values listed here-called a reference range-are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what's normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.
Your doctor will evaluate your results based on your age and gender. In general, normal values for BNP are less than 100 picograms per milliliter (pg/mL) or less than 100 nanograms per liter (ng/L).1
The amount of a related substance, called N-terminal pro brain-natriuretic peptide (NT-proBNP), may be measured instead of BNP. The results from the NT-proBNP test are different than those from the BNP test but provide similar information. Normal values for NT-proBNP are less than 400 pg/mL or less than 400 ng/L.1
High values
A high value of BNP in the blood:
- Means an increased amount of fluid or high pressure inside the heart.
- May be used to help determine the severity of heart failure.
- May mean a higher chance of death in people with heart failure.
- May show early heart failure in people on kidney dialysis.
What Affects the Test
Reasons you may not be able to have the test or why the results may not be helpful include:
- Having lung disease, such as emphysema or chronic obstructive pulmonary disease (COPD).
- Having kidney disease, kidney dialysis, or a heart attack.
What To Think About
- The BNP level may get lower if treatment for heart failure is working. But the BNP level may stay above the normal BNP level even when a heart failure treatment is working well. Your doctor will use your physical exam and other tests, along with your BNP level, to make sure your treatment is working.
Fischbach F, Dunning MB III (2015). A Manual of Laboratory and Diagnostic Tests, 9th ed. Philadelphia: Wolters Kluwer Health.
Other Works Consulted
Chernecky CC, Berger BJ (2013). Laboratory Tests and Diagnostic Procedures, 6th ed. St. Louis: Saunders.
Fischbach F, Dunning MB III (2015). A Manual of Laboratory and Diagnostic Tests, 9th ed. Philadelphia: Wolters Kluwer Health.
Pagana KD, Pagana TJ (2010). Mosby's Manual of Diagnostic and Laboratory Tests, 4th ed. St. Louis: Mosby Elsevier.
Wilson Tang WH, et al. (2007). National Academy of Clinical Biochemistry laboratory medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. Circulation, 116(5): e99-e109.
Yancy CW, et al. (2013). 2013 ACCF/AHA Guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology, 62(16): e147-e239.
ByHealthwise Staff
Primary Medical ReviewerE. Gregory Thompson, MD - Internal Medicine
Specialist Medical ReviewerStephen Fort, MD, MRCP, FRCPC - Interventional Cardiology
Current as ofAugust 7, 2015


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HOUSTON - Deputies need help identifying and finding two men who robbed a cellphone store in the Cloverleaf area.
Harris County sheriff's deputies said two men armed with a handgun walked into a store in the 13300 block of Woodforest Boulevard about 8:30 p.m. on Oct. 12.
One of the robbers walked up to the counter while the second one held the store's front door open, investigators said.
The first robber told an employee to fill a bag with money and other valuables, detectives said.
The first robber was described as Hispanic, 20 to 25 years old, 5 feet 8 inches to 5 feet 10 inches tall and 200 to 220 pounds with short black hair. He was last seen wearing a white T-shirt, blue jean shorts and a black scarf around his head and neck.
The second robber was described as Hispanic, 20 to 25 years old, 5 feet 6 inches to 5 feet 7 inches tall and 160 to 170 pounds. He was last seen wearing a gray T-shirt and red athletic shorts.
Deputies said the men got away in a tan Chevrolet Suburban.
Anyone with information is asked to call Crime Stoppers at 713-222-TIPS.
Copyright 2012 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Tuesday, September 26, 2017
Senior Health
Lack of Diagnosis for 72 year old
For 3 months my mother, 72, has been feeling faint and having night sweats. This has escalated in the last month to include severe upper body (torso, arms) pain, so intense it has caused her to faint. The pain worsens at night but does not ever go away without painkillers. She is currently in hospital undergoing tests but doctors have ruled out polymyalgia as she didn`t respond to steroid treatment. I`ve noticed that in the last week she has developed large hemetomas on her arms where they have extracted blood. Thsi didn`t occur until recently. She also has many pinprick sized blood marks on her lower legs. She has lost considerable weight, at least a dress size. Other points to note are that she visited South Africa (Cape Town) for two weeks 4 months ago. She had a cough about a month ago but that has gone away. There was no bloody mucous from the cough. The hospital is conducting tests very slowly and I`m concerned that they think as long as the pain in under control then they have as much time as needed to diagnose. Any advice on what tests to ask for would be appreciated.
On the basis of information given I am unable to give an opinion on this 72 yr old with multiple symptoms without proper examination and knowing the findings on blood tests and imaging (thoracic spine/chest and brain MRI) etc.
It seems she is in good hand being hospitalized and investigated. I am not sure about the cause of upper body pain if she has not responded to steroids, skin rash appears to be a bleeding (hematological) problem or a dermatological! It is unclear if there is a relationship to travel to South Africa and if any disease was acquired there via vectors or personal contact.
Arvind Modawal, MD, MPH, MRCGP
Professor of Family & Community Medicine, Geriatrics and Palliative Care
College of Medicine
University of Cincinnati


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A Phase 3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Primary Progressive or Relapse-free Secondary Progressive Multiple Sclerosis
This study is currently recruiting participants.
Verified April 2017 by AB Science
AB Science
Information provided by (Responsible Party):
AB Science
ClinicalTrials.gov Identifier:
First received: September 12, 2011
Last updated: April 20, 2017
Last verified: April 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to compare the safety and efficacy of masitinib 6 mg/kg/day versus placebo in the treatment of patients with primary progressive multiple sclerosis or relapse-free secondary progressive multiple sclerosis.
|Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Relapse Free
|Drug: masitinib Drug: placebo
|Phase 2 Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A 96 Week, Prospective, Multicentre, Randomized, Double-blind, Placebo-controlled, 2 Parallel-groups, Phase 3 Study to Compare Efficacy and Safety of Masitinib 4.5 mg/kg/Day Versus Placebo in the Treatment of Patients With Primary Progressive or Relapse-free Secondary Progressive Multiple Sclerosis
Resource links provided by NLM:
Genetics Home Reference related topics: multiple sclerosis
MedlinePlus related topics: Multiple SclerosisU.S. FDA Resources
Further study details as provided by AB Science:
Primary Outcome Measures:
- EDSS [ Time Frame: week 96 ]
Secondary Outcome Measures:
- Multiple Sclerosis Quality of Life 54 items (MSQOL-54) [ Time Frame: week 96 ]
- Multiple Sclerosis Functional Composite (MSFC) [ Time Frame: week 96 ]
|Estimated Enrollment:
|Study Start Date:
|August 2011
|Estimated Study Completion Date:
|July 2019
|Estimated Primary Completion Date:
|January 2019 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: masitinib
masitinib 4.5 mg/kg/day
Drug: masitinib
6 mg/kg/day
|Placebo Comparator: placebo
Drug: placebo
masitinib matching placebo
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patient suffering from either primary progressive or secondary progressive multiple sclerosis without relapse within 2 years before inclusion according to the revised McDonald's criteria
- Patient with EDSS score of [2.0 to 6.0] inclusive at baseline
- Patient who had an EDSS score progression ≥ 1 point confirmed by a second evaluation carried out at least 6 months apart, within 2 years before inclusion
Exclusion Criteria:
- Patient suffering from a disease other than MS that would better explain the patient's neurological clinical signs and symptoms and/or MRI lesions
- Patient in who MRI examination and injection of gadolinium contrast agents should not be used
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01433497
Please refer to this study by its ClinicalTrials.gov identifier: NCT01433497
|Contact: Patrick Vermersch, MD, PhD
|Hospital de la Santa Creu i Sant Pau
|Barcelona, Spain, 08041
Sponsors and Collaborators
AB Science
More Information
Keywords provided by AB Science:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|AB Science
|ClinicalTrials.gov Identifier:
|NCT01433497 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 12, 2011
|Last Updated:
|April 20, 2017
Keywords provided by AB Science:
multiple sclerosis
primary progressive
secondary progressive
Additional relevant MeSH terms:
Multiple Sclerosis
Multiple Sclerosis, Chronic Progressive
Neoplasm Metastasis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Neoplastic Processes
Disease Attributes
ClinicalTrials.gov processed this record on September 21, 2017