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RSL scores twice in 2nd half, wins
SANDY, Utah -- Defense proved to be a perfect solution for Real Salt Lake's problems.
There were no early goals or shaky early possessions like last week's loss to the Los Angeles Galaxy. Instead, Salt Lake experienced steady improvement over 90 minutes and it added up to a positive result.
Luis Gil ended a scoring drought with a header just minutes into the second half and Javier Morales also had a goal to lead Salt Lake to a 2-0 victory over the Vancouver Whitecaps on Saturday night.
Salt Lake (4-4-2) played without its top three forwards as Alvaro Saborio, Robbie Findley and Olmes Garcia all were sidelined because of injuries. It forced head coach Jason Kreis to use his ninth different starting lineup this season.
The Whitecaps (2-4-3) extended their MLS winless streak to seven games. Vancouver has not won since a 2-1 home victory over Columbus on March 9. The Whitecaps have given up at least two goals in five of those seven contests
"You got to play through the whole game," Vancouver coach Martin Renne said. "The second half wasn't good enough."
Neither team generated much offense before halftime. Salt Lake managed just two shots on goal while Vancouver did not have a shot.
Kreis admitted his team struggled out of the gate trying to find a rhythm in its passing game. After halftime, though, he thought Salt Lake made increasingly better tactical choices.
"I felt like we got better and better and better as the game went on and I have to feel good about it," Kreis said. "That's what we want. We want a team that is capable of improving during a match and calm enough to do so."
Salt Lake got on the scoreboard on Gil's goal in the 47th minute. Nick Rimando set the scoring play in motion with a booming goal kick, and Plata corralled the deep ball on the right flank and sent a cross into Gil, who simply lunged forward and headed the ball into the net.
The Whitecaps nearly tied it in the 61st minute when Corey Hertzog challenged Rimando and flicked the ball past his feet. The ball puttered along the goal line before Nat Borchers charged after it and cleared it off the line to preserve the lead.
Morales made it 2-0 in the 71st minute as he tapped a running right footer inside the left post. Plata also set up this goal, sending a short cross to Morales in the center of the box after Sebastian Velasquez fed the ball ahead to him.
The Whitecaps really never threatened to cut into the lead because Rimando rarely faced any dangerous attack situations. Salt Lake controlled possession and made his 102nd MLS career shutout one of the easiest he has had so far.
"When I don't have to make a lot of saves, it's my best game," Rimando said. "That means we're organized. That means the defense is intact and the whole team is playing defense."
Rennie said his team needs to do a little soul searching after yet another road loss. He feels like Vancouver needs to make the loss a turning point and go in a positive direction.
"Players who do very well at home are letting us down away from home," Rennie said. "I can't put my finger on why, but they really need to look at themselves and ask if they are giving enough to the club. The club does everything for them."
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Hanson throws simulated game, nearing return
KANSAS CITY -- Right-hander Tommy Hanson threw a five-inning, 75-pitch simulated game on Saturday in Arizona and appears to be on the verge of rejoining the Angels' staff.
"He had a good workout," manager Mike Scioscia said. "He'll be evaluated to make sure, but he should be another guy we're folding into the rotation this week if everything comes out all right."
Hanson was 2-1 with a 3.86 ERA in five starts prior to his stint on the restricted list.
Robert Falkoff is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.

subset: commoncrawl


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8 years


text: Home Gallery Print (image) G.Q. Evil Instincts - Mark Strong (print) G.Q.: Evil Instincts - Mark Strong (print) Bad guys do chores too. Published on Jun 01, 2012 Editor's Pick For GQ, director/photographer Nadav Kander turns his camera on celebrities including Benicio del Toro, Malcolm McDowell, and Ron Perlman, in a series of short films depicting them performing activities which appear deeply menacing but turn out to be nothing more sinister than doing household chores. The project began as a series of stills, entitled 'Bad Guys', commissioned by GQ to be photographed by Kander. This presented an opportunity to shoot accompanying short films, which will appear on the iPad edition of GQ's June issue. They mark the commercial motion film debut for Kander, whose previous work includes portraits of Barack Obama and David Lynch, and were edited by JD Smyth of Final Cut. The stills appear in the June print edition as well as the iPad version. Rate this Ad You must be registered to rate the ad. Please Login or Register Now About CreditsDateJun 01, 2012Client:G.Q.Photographer:Nadav KanderDirector:Nadav KanderEditorial Company:Final CutEditor:JD SmythPresident:Stephanie AptEP:Lauren BleiweissProducer:Viet-An NguyenAsst Editor:Spencer CampbellColorist:Pearly LeungVFX/Online:Cecil HookerGraphic Design:Phil BrooksSound Design/Mix:T. Teressa TateSound/Music Company:Barking OwlSound/Music:Michael AnastasiSound/Music Producer:Kelly BayettEP:Lisa MehlingProduction Company:Chelsea Pictures CategoryWeb Film Latest Creativity News on Ad Age Rihanna's Fenty Line is a Wake-Up Call for the Retail Industry Yanagisawa Joins Blink, Sibling Rivalry Signs Margetson Your Wednesday Wake-Up Call: Amazon's Email Glitch, Bob Evans' Sale and Other News to Know Today Related work G.Q.: Evil Instincts - Malcolm McDowell (print) G.Q.: Evil Instincts - Jack Gleeson G.Q.: Evil Instincts - John Hawkes (print)


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Saracens wing Chris Ashton has been recalled to England's side for the final Test in New Zealand on Saturday.
Ashton came off the bench to score in last weekend's defeat to the All Blacks and has been rewarded with his first international start of the season.
Sarries forward Billy Vunipola is also brought back into Stuart Lancaster's team for the match in Hamilton.
Owen Farrell misses the game after suffering a knee injury.


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Curling Shoe Maintenance
Are my curling shoes ready for the season?
Here at Goldline, customers often come into the store with their curling shoes in hand, wanting to know if they should be buying new shoes. Here is an overview of the discussion I will typically have with the customer.
First and foremost, fit is the most important thing that you need in a curling shoe. It doesn't matter how much money you originally spent on the shoe and whether the shoe is in pristine condition with fine unscathed leather. If it doesn't fit properly, you probably shouldn't be wearing it. If the shoe is tight and/or uncomfortably rubbing your toes/ankle, or causing blisters, or if the shoe is so loose that your foot is not secure in it, it is likely time to consider investing in a new pair.
Customers are often worried about scratches on the surface of the Teflon slider. It is inevitable that the slider will get marks in it, as there are bound to be minute pieces of debris on the ice which your shoe will slide over in the course of delivering a rock. But Teflon is an extremely hard and durable material and it is rare that the scratches are so deep that it impairs one's sliding ability. I do occasionally see shoes with very thin Teflon sliders where a piece of the Teflon has actually broken off, typically as a result of the shoe being used to move or stop rocks that are in motion. You don't want to slide on the shoe in this case; new shoes or a slider replacement is in order in this situation.
Now, although it is not technically part of the shoe, the anti-slider that covers the slider on your shoe also merits inspection on a regular basis. I believe that as a minimum, you should be replacing the anti-slider at least once per season, at the start of the season. You need to inspect not only the outer surface; just as important is to inspect the inside of the anti-slider which will also deteriorate over time.
The final step is to assess the overall appearance of the shoe. Leather is durable but if you use your feet to move rocks around, your shoe is going to deteriorate quickly. Use your broom to move the rocks! The outer shell of the shoe was not built to withstand regular contact with 42-pound slabs of granite.
It is also very normal for the toe of the dragging foot to become scuffed. You can put a small piece of clear sliding tape over the toe to minimize this. Many people put a "toe coat" on the dragging foot; this is a thin layer of epoxy that protects the toe. But be warned: not only does the toe coat provide protection, it also reduces the amount of drag provided by the trailing leg, so much so that the trailing leg may have a tendency to fishtail. Be sure to get out and get some practice time when you get a toe coat for the first time.
Curling shoes: they're an investment and with care, they can serve you well for many years.


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Clippers get
TJ Ford 2 yr, 16.50M
Sergio Rodriguez 1 yr, 1.58M
Trailblazers get
Baron Davis 4 yrs, 53.75M
Pacers get
Travis Outlaw 1 yr, 3.60M
Steve Blake 1 yr, 4.00M
Pacers get salary relief in the form of two good players.
Clippers get HUGE salary relief.
Blazers get the top tier PG they are looking for.
My only concern with this deal is that it will make things much more difficult for Portland to sign all of their young studs. They might sacrifice a few players in trading for BDiddy.


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POTTER VALLEY -- Kelsey Pearl scored 15 points and LaShaye Taylor contributed 14 more on Friday night as the Upper Lake Cougars built a big halftime lead en route to beating the Potter Valley Bearcats 52-28 in the season opener for both of these varsity girls' basketball teams at Potter Valley.
"I was wondering how we'll replace Kat's scoring this season, but I think we're a deeper team," Upper Lake coach Mike Smith said of his 2012-13 squad.
Kat Edmonds, who graduated in June, averaged a Lake County-best 16.7 points a game for the Cougars a year ago, but no one else on the squad averaged more than 7.1.
Upper Lake (1-0) built a 28-9 halftime lead and outscored Potter Valley in every quarter.
"Monica Diaz controlled the tempo of the game," Smith said of his junior point guard who had five assists and two points. "I thought she played great."
Robin Martin had eight points for the Cougars, who are a mix of veterans and young players.
Upper Lake also won the JV game 36-16 behind 19 points from Autumn Martinez.


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|You think I look good in this bikini? Just wait until you see my nude photos inside the site. You will see how good my body really is. I have a lot to show and I love to show it. The men seem to like me too.
|I love being young and being blessed with the gifts I've been given and I'm glad I can share them with all my fans. Who knows what else is coming or what I'm going to do, but you will be sure to find out


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Southern California High Tech Event Calendar
|View By:
|View By:
|Clean and Green Energy Forum
|Date: December 03, 2012
|Location:Dana Point
|Clean and Green Energy Forum. With rising costs of oil and natural gas, we find ourselves in a global movement focusing on a need for cleaner and more efficient energy options. Opal Event's Clean and Green Energy Forum: Investing for a Renewable Future will bring together experts from throughout the country to discuss the most important topics in cleantech and greentech. Keynote: T. Boone Pickens, Founder & CEO, BP CAPITAL MANAGEMENT. See http://www.opalevents.org/p/81/clean-and-green-investment-forum/
|More information: http://www.opalevents.org/p/81/clean-and-green-investment-forum/
|Download to Calendar


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A seizure is abnormal electrical activity in the brain. When 2 or more seizures occur, it is considered a seizure disorder, also known as epilepsy. While there are many different types of seizures, the main categories are:
Generalized Seizure
Copyright © Nucleus Medical Media, Inc.
Seizure disorder is caused by abnormal brain function. It is often difficult to identify the exact cause, but some factors that may play a role include:
Factors that may increase your child's chance of seizure disorder include:
Symptoms can vary depending on the type of seizure disorder. These may include:
You will be asked about your child's symptoms and medical history. A physical exam will be done.
Tests may include:
Imaging tests evaluate the brain and surrounding structures. These may include:
Your brain may be tested. This can be done with:
You will work with the doctor to choose a treatment plan that is right for your child. Treatments options include:
There are many different kinds of medications to treat seizure disorder. The exact medication will be based on the specific type of seizures and symptoms your child has. Anti-epileptic medications are a common option. In some cases, anti-epileptic medications may be used in combination.
If medication does not work or the side effects are too severe, your child may need surgery. Surgery involves the removal of the area of the brain that starts the seizure. Surgery is only an option if your child has localized areas of the brain involved.
With VNS, a device is implanted in the chest to give electrical stimulation to the vagus nerve. This nerve runs from the brain to beyond the stomach. Stimulation can prevent or decrease the frequency of seizures. Medication may still be needed.
A ketogenic diet is a strict diet. It is high in fat and low in carbohydrates and proteins. It keeps the body's chemical balance in a state of ketosis. Ketosis decreases the frequency of seizures. If you would like your child to start this diet, talk to the doctor. Since your child needs proper nutrients, you will need to work with a dietitian.
Your child's doctor may ask you to keep note of what was happening when your child had a seizure. This may help identify and make plans to avoid seizure triggers. These triggers can vary from child to child but some examples include:
Help your child to decrease the chance of a seizure by:
Other things to consider:
There are no known ways to prevent every type of seizure disorder. You can take steps to prevent your child from brain injuries or conditions that could lead to seizures:
Epilepsy Foundation
National Institute of Neurological Disorders and Stroke
Center for Epilepsy and Seizure Education
Epilepsy Ontario
Epilepsy. American Association of Neurological Surgeons website. Available at: http://www.aans.org/Patient%20Information/Conditions%20and%20Treatments/Epilepsy.aspx. Accessed September 15, 2015.
Growing up with epilepsy: activities, safety, and first aid. Massachusetts General Hospital website. Available at: http://www2.massgeneral.org/childhoodepilepsy/overview/index.htm. Updated November 20, 2006. Accessed September 15, 2015.
Living with epilepsy. Patient UK website. Available at: http://www.patient.co.uk/showdoc/23068986. Updated June 5, 2015. Accessed September 15, 2015.
Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008 May 2. [Epub ahead of print]
Seizure in children. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T550165/Seizure-in-children. Updated April 11, 2016. Accessed September 15, 2016.
Seizures. Boston Children's Hospital. Available at: http://www.childrenshospital.org/health-topics/conditions/seizures. Updated 2010. Accessed September 15, 2015.
5/6/2011 DynaMed Plus Systematic Literature Surveillance http://www.dynamed.com/topics/dmp~AN~T550165/Seizure-in-children: Quet F, Guerchet M, Pion SD, Ngoungou EB, Nicoletti A, Preux PM. Meta-analysis of the association between cysticercosis and epilepsy in Africa. Epilepsia. 2010 ;51(5):830-837.
Last reviewed September 2016 by Kari Kassir, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © 2012 EBSCO Publishing All rights reserved.
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Feed costs are expected to moderate this year — at least compared to the sky-high figures encountered last year — but it is still vitally important to get the most out of every ounce of feed.
New technologies are available to help producers accomplish this. These technologies really get in there and analyze the feeding value of corn silage and other ingredients — and also spot inconsistencies, such as when a farm begins feeding from a new bunker of corn silage.
"On paper your ration might say a certain percentage of starch is available to the cow. But in reality it might be a completely different percentage," says Jeff Harris, nutritionist with EPL Feeds in central Washington.
There are a number of traditional lab tests that help. But new technologies take it one step further.
Crude protein analysis on forages and key ingredients has been the normal approach by nutritionists over the years. Fiber measurements, particularly ADF and NDF, provide guidance on intake and digestibility. And, starch values are obtained on corn silage to enhance strategies to maximize energy intake, while also avoiding potential "starch overload."
However, these approaches overlook the impact of the digestibility of key crude nutrients, points out David Weakley, director of dairy forage research for Calibrate Technologies.
"For example, higher dietary starch levels can be both safe and desirable if ruminal digestibility of one or more starch sources is low," Weakley says. "Moreover, high-forage diets can produce very high levels of milk production, despite their lower energy density, if their ruminal NDF digestibility is high, allowing for greater dry matter intake, particularly with higher-producing cows. Therefore, knowing the ruminal digestibility of key nutrients can offer the opportunity to recommend an assortment of diets to meet current economic and ingredient inventory conditions," he adds.
Here are a couple of case studies that illustrate this concept in action:
Case 1
The following case was handled by Barry Dye, senior dairy consultant with Purina Animal Nutrition, LLC.
A North Carolina mixed breed herd — part Jersey, part Holstein and part Jersey-Holstein cross — expanded from approximately 300 cows in the milking herd to 840.
Even though the expansion involved a new free-stall barn, the owners felt that given the size of the holding pen and other potential bottlenecks, it was best to switch from three-times-a-day milking to 2X.
The switch from 3X to 2X occurred in November 2012. Anytime a switch like that occurs, the farm risks losing some milk production — and, in this case, it wasn't the outcome the owners wanted. They felt there was still untapped milk production potential in the herd, despite the switch to 2X milking.
So, they challenged nutritional consultant Barry Dye to look at the rations and see if there were some opportunities. Is there more milk in these cows? they asked.
Dye reviewed the rations and they looked OK on paper. Dry matter intake didn't appear to be a problem, either.
It would require closer inspection.
Dye turned to a forage diagnostic system known as Calibrate. And, the first set of results certainly got his attention. The rumen undegradable NDF score — a measure of undegraded NDF mass in the rumen — was higher than 100 in a couple of the key feeding groups.
That told him two things:
• Dry matter intake may be limited by undegraded feed/rumen fill.
• More degradable starch is needed in the diet.
"When that score is greater than 100," it indicates that "if we increase the NDF digestibility or decrease the amount of NDF in the diet, there is a likelihood we can increase dry matter intakes," Dye says.
More and more evidence came in. Another component of the Calibrate test turned up rumen degradable starch scores that were lower than Dye wanted to see.
Since the farm was already targeting its better forage to the high-producing cows, there wasn't a lot of opportunity to feed more digestible NDF from the current feed supply. So, Dye cut back some of the forage, which lowered the amount of NDF in the diets.
It's worked out pretty neat, because some of room that was left in the diet gave us more room to increase the amount of fine-ground corn we were feeding, and that let us raise our ruminally degraded starch scores," he said.
There was an immediate response. Within a three-week period, the herd average moved from 62 pounds of milk per day to 68. Even with 6 extra pounds of milk, the components remained constant — butterfat at 4.1 percent and protein at 3.15 percent.
Meanwhile, the farm owners "have been extremely satisfied," Dye says.
And, it turned out that the owners' intuition was right — the cows did have more milk in them that needed to be utilized.
Bottom-line: Calibrate gave Dye a powerful tool to dig deeper and peer into what was going on in the feed and the rumen
Case 2
Editor's note: The following case was handled by Wade Steen, dairy nutritionist in Roswell, N.M.
It was baffling: Two herds identical in many ways, owned by the same person, but different in how they handled the introduction of dried distillers grains into the ration.
Each of the herds was 2,500 cows, located in southeast New Mexico.
The herd managers and nutritionist tried including a moderate amount of dried distillers grains — 4.5 pounds on a dry-matter basis — into the ration.
In one herd, the butterfat remained constant following the inclusion of DDGs. But, in the other herd, butterfat dropped dramatically from 3.2 percent to 2.7 percent. This was puzzling, since both herds had the same rations, the same forage base — even the same feed mixer and feed truck.
Intuitively, most people would focus on the DDGs. But, could it be something with the grain? Or starch levels?
Nutritionist Wade Steen already had a good baseline to work from. For four months, he had been testing out a new forage diagnostic system known as Calibrate from Forage Genetics International.
"Calibrate not only allows me to monitor starch level in the ration, but gives me an accurate, predictable estimate of how degradable that starch is in the rumen," Steen says.
"I knew where the starch levels were (and they did not change following inclusion of DDGs), so I knew it wasn't starch," he adds.
He also knew that his forage and digestible NDF levels were adequate.
Digestibility of the forage is a difficult thing to stay on top of since the degradability of corn silage can change during the course of year, even among silage stored in the same pit or bunker silo. But Calibrate allowed Steen to monitor this before and after inclusion of the DDGs.
So, with those other things out of the way, Steen was quickly able to move on to the next rule-out, which was polyunsaturated fatty acid (PUFAs) from the distillers grains. In this case, one of the herds apparently did not react to the introduction of PUFAs as favorably as the other herd. Once the DDGs were removed, the herd's butterfat came back up within a matter of three to four days. Within 10 days, butterfat was 3.2 percent, which was normal. Herds in New Mexico are generally around 3.2 percent butterfat for much of the year, Steen says.
Sidebar: 'It's an unbelievable tool'
Fermentrics, a new diagnostic test that measures the digestion rates of feed samples, is generating buzz in the industry.
"I think it's such a valuable tool for the dairy industry, I've been trying to get nutritionists and producers to understand its practical utility," says Bill Mahanna, global nutritional sciences manager at DuPont Pioneer.
With Fermentrics, an individual feed or TMR sample is placed in a closed vessel with rumen fluid to measure fermentation gas production. The automated system produces 5,000 data points over the 48-hour incubation. Sophisticated curve-peeling software is used to separate the gas curves into a "fast pool" and a "slow pool." While not completely homogeneous, the fast pool consists mostly of starch and the slow pool consists mostly of fiber. This gives a more accurate picture of digestion kinetics than traditional methods that may only use one or two time points.
Mahanna likens it to charting a runner's progress in a long-distance race. If the runner's progress is charted only once — say, at the end of six miles — it gives an indication of his speed.
"What would be a better indicator of his running ability would be to measure his time for each and every mile," he says. "And, in a way, that is kind of what Fermentrics is — it's allowing us to measure continuously over the whole fermentation to see the rates of digestion at various time points."
From the data, a graph is developed from which the carbohydrate digestion rate values are calculated. These values can be used in sophisticated ration-balancing programs rather than relying on book values populating the feed libraries.
The Fermentrics methodology also allows for direct measurement of microbial biomass production, or "how many rumen bugs grow on the sample." This is a powerful metric that can be used to compare feedstuffs or TMR samples. The Fermentrics report also includes an innovative new approach to measuring soluble protein, which many nutritionists believe provides a more realistic value than the traditional borate-buffer soluble protein method used by most laboratories.
The possible applications of Fermentrics are endless.
• Troubleshooting forage quality. For instance, a nutritionist can order separate analyses of the TMR and the corn silage. If the corn silage comes back high in microbial biomass production and digestion rate, but the TMR is not so good, then it's something else in the TMR besides corn silage — typically, the legume/grass forages? that's holding things back.
• Formulating rations. With Fermentrics, you can run an analysis ahead of time and get a good idea of whether the new ration will work. "Theoretically, you could use Fermentrics to put together a couple of different scenarios for rations," Mahanna says. That might be cheaper over the long run "than trying to wait for the cows to tell us (how a ration is doing)," he adds.
• Benchmarking successful rations. One opportunity often overlooked by nutritionists is sampling the forages or TMR when cows are performing well, and using this as a benchmark to work toward when production falters.
The price of Fermentrics (including all of the traditional analysis values) is $145 for a TMR and $125 for individual ingredients or forages. Mahanna calls it "a very reasonable price for all of the information that is measured by this innovative methodology."
"It's an unbelievable tool," he adds.
Dairyland Labs in Arcadia, Wis., offers Fermentrics in cooperation with
RFS Technologies from Ottawa, Canada.


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Odds OdditiesProbability puzzles require you to weigh all the possibilities and pick the most likely outcome.
You roll a die 24 times, and the results are as follows:
[1] 6 times
[2] 4 times
[3] 5 times
[4] 3 times
[5] 6 times
[6] 0 times
What are the odds of the twenty fifth die being a six?
(probability 1/6)
Dice have no memory, so previous rolls have no bearing on future rolls.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
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You are here:
NIAMS Labs Core Facilities
Updated January 5, 2013
The Office of Science and Technology (OST) is responsible for NIAMS Labs core facilities. It provides and develops new technologies, advises the Scientific Director, Lab and Branch Chiefs, and other key officials on science and technology. OST initiates collaborative, cooperative and service activities that facilitate the conduct of science and coordinates the core technological facilities of the Intramural Research Program.
We strive to provide you with the best possible and most up-to-date instrumentation, and to guide and train you to take advantage of our instruments and technologies so you can get the most out of your experiments.


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Stuttgart – Defending champion Maria Sharapova survived a first-round scare at the Porsche Grand Prix by defeating Lucie Safarova 7-6(5), 6-7(5), 7-6(2) on Tuesday.
The sixth-seeded Sharapova needed three hours, 24 minutes for her 100th clay victory, three days after her 27th birthday.
Sharapova, who is bidding to win the tournament for the third time in a row, next faces fellow Russian Anastasia Pavlyuchenkova, who defeated Latvian qualifier Diana Marcinkevica 6-3, 6-2.
Jelena Jankovic, the no 5 seed, saved four match points to come back and claim a 2-6, 7-6 (8), 6-3 win over German lucky loser Mona Barthel.
No 8 seed Sara Errani recovered from a double break down in the second set to defeat Klara Koukalova of the Czech Republic 6-3, 6-4 for the Italian's first win in five visits to Stuttgart.
Also on Tuesday, Svetlana Kuznetsova beat Italian qualifier Gioia Barbieri 6-2, 6-3 and another Russian, Alisa Kleybanova, defeated Croatia's Ajla Tomljanovic 6-2, 6-4.
Spain's Carla Suarez Navarro defeated Russia's Ekaterina
Makarova 6-0, 6-4 and Roberta Vinci had a 6-3, 6-2 win over Annika Beck, ensuring the 20-year-old qualifier was the first German knocked out of the tournament. – Sapa-AP


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VIDEO: Jessica Chastain, Dan Stevens Chat THE HEIRESS on GMA
On this morning's 'Good Morning America' on ABC, Jessica Chastain and Dan Stevens discussed the excitement surrounding their first Broadway play, The Heiress. GMA host Lara Spencer asked Stevens about the real reasons behind his character's courting of the young heiress. "We like to keep 'em guessing,' joked the actor. "That's the fun of this play." Chastain spoke of her vast theater experiences sharing, "I've actually done more plays than film, which will probably be a surprise to people." Check out their appearance below!
The Heiress stars Academy Award nominee Jessica Chastain as Catherine Sloper, Academy Award nominee and Emmy Award winner David Strathairn as Dr. Austin Sloper, the leading man of "Downton Abbey" Dan Stevens as Morris Townsend and Tony Award winner Judith Ivey as Lavinia Penniman. Written by Ruth & Augustus Goetz, The Heiress is directed by two-time Tony Award nominated playwright and director Moisés Kaufman.
The Heiress is produced by Paula Wagner, Roy Furman, Stephanie P. McClelland, Luigi Caiola/Rose Caiola, Jim Herbert, Ted Liebowitz, Stacey Mindich, Jill Furman, Ricardo Hornos, Jon B. Platt, Eric Schmidt, Margo Lion/Rachel Weinstein and Jujamcyn Theaters.
Dan Stevens is appearing with the support of Actors' Equity Association. The Producers gratefully acknowledge Actors' Equity Association for its assistance of this production.
The Heiress is the story of Catherine Sloper (Chastain), the shy and sheltered daughter of a prominent New Yorker. Caught between the demands of an emotionally distant father (Strathairn) and the attentions of a passionate young suitor (Stevens), Catherine must navigate the terrain of love and regret, desire and duty, a chance for happiness and the burden of fortune…as only an heiress can.
Tickets for The Heiress are available by visiting Telecharge.com, calling (212) 239-6200 and at the box office of the Walter Kerr Theatre (219 W. 48th St. NYC). Ticket prices range from $50.00-$135.00. Group bookings are being accepted. Please visit www.telecharge.com/groups or call Telecharge Group Sales at 800-432-7780.


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Getting Ready for Summer Organizer Class 2011
I'm so excited to be welcoming our new class of summer organizers.
By the time applications closed last week, thousands of people had applied. Staff in every state are reaching out to people, carrying out interviews and making offers to applicants to join the program this summer.
Justin Wilkins, Tennessee State Director, has been talking to folks all week.
The most exciting thing for me about these summer organizer interviews is talking with so many applicants across the state who have watched two years of incredible progress, seen ups and [downs]—and now with our future at stake, are willing to sacrifice so much this summer to build this movement again.
Don't worry if you applied and haven't heard from us yet—we'll be in touch over the coming days.
The program officially kicks off the weekend of June 4th and 5th with an intensive training session for all the summer organizers in each state. It will be a whirlwind look at key organizing tactics and tools, including how to hold one-on-one conversations, how to organize a phone bank, and learning the story of the campaign—everything they'll need to know to be a great summer organizer.
This year's class is shaping up to be an awesome group. Folks are young and old, coming from all walks of life. I'm really looking forward to seeing what they achieve.
If you're not part of the summer organizer program, there are lots of other ways you can be part of the campaign. Find out how you can get involved in your community.
We'll be checking in with some of the summer organizers in the coming weeks and sharing their stories here on the site. Make sure to check back to find out how organizers like Taylor and Char are getting on.


text:
Efficacy of Albuterol in the Treatment of Congenital Myasthenic Syndromes
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Congenital Myasthenic Syndrome
|Drug: Albuterol
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Efficacy of Albuterol in the Treatment of Congenital Myasthenic Syndromes
- Name: Efficacy of albuterol in the treatment of congenital myasthenic syndromes [ Time Frame: 3 years ]The primary outcome measures pertain to evaluating the improvement in the patient's strength
|Study Start Date:
|September 2010
|Study Completion Date:
|August 2013
|Primary Completion Date:
|August 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Albuterol
4 mg twice daily by mouth for adults. The dose for children 6 to 12 years is 2 mg two or three times daily; the dose for children 2 to 6 years is 0.1 mg/kg/day (maximum 2 mg) three times daily.
Drug: Albuterol
4 mg twice daily by mouth for adults. The dose for children 6 to 12 years is 2 mg two or three times daily; the dose for children 2 to 6 years is 0.1 mg/kg/day (maximum 2 mg) three times daily.
Other Name: Ventolin
Detailed Description:
The aim of the proposal is to evaluate the effects of albuterol, an adrenergic agonist, in the treatment of congenital myasthenic syndromes (CMS). Over the past 2 decades I found that some CMS patients refractory to or worsened by cholinergic agonists, namely those suffering from defects in acetylcholinesterase (AChE) or Dok-7, respond to ephedrine, a medication used for over half-a-century in the treatment of autoimmune myasthenia gravis. After ephedrine became unavailable, I treated the same type of patients with albuterol in doses ranging from 4 mg daily to twice daily for adults; the dose for children 6 to 12 years is 2 mg two or three times daily; the dose for children 2 to 6 years is 0.1 mg/kg/day (maximum 2 mg) three times daily. Evaluation of the effects of the medications are based on the Table shown below.
Mayo Clinic no:
Date of this report: (dd/mm/yyyy):
Before taking Albuterol ER On Albuterol (date of this report)
- Current daily dose of albuterol:
Dates when started (d/m/year) Daily dose Distance in feet walked without stopping to rest Number of steps climbed without stopping to rest Difficult to sit up from lying on back* Difficult to rise from sitting* Difficult to speak or swallow* Shortness of breath on exertion* Shortness of breath at night* Weakness of arm or hand muscles * Weakness of leg or foot muscles*
*Rate as mild, moderate, severe Describe below any additional changes in your condition such as arm elevation time, number of deep knee bends before having to stop, or in activities of daily living relevant to the effects of the treatment. Also indicate any unwanted side effects of the medication. Continue on other side or separate page if necessary. Return this questionnaire to Dr. Andrew Engel (email:email@example.com) ,after treatment with albuterol for 1 month and then monthly thereafter, or mail to Dr. Andrew Engel, Department of Neurology, Mayo Clinic, Rochester, MN 55905.
|Ages Eligible for Study:
|2 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of congenital myasthenic syndrome substantiated by typical clinical history, seronegativity to AChR and MuSK, and evidence of a decremental EMG response.
Exclusion Criteria:
- Uncontrolled hypertension, arrhythmias, or other significant cardiac disease.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01203592
|United States, Minnesota
|Mayo Clinic
|Rochester, Minnesota, United States, 55905
|Principal Investigator:
|Andrew G Engel, MD
|Mayo Clinic
|Responsible Party:
|Andrew Engel, PI, Mayo Clinic
|ClinicalTrials.gov Identifier:
|NCT01203592 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 15, 2010
|Last Updated:
|December 31, 2015
Keywords provided by Andrew Engel, Mayo Clinic:
Congenital myasthenic syndrome
Neuromuscular transmission
Additional relevant MeSH terms:
Lambert-Eaton Myasthenic Syndrome
Myasthenic Syndromes, Congenital
Paraneoplastic Syndromes, Nervous System
Paraneoplastic Syndromes
Pathologic Processes
Nervous System Neoplasms
Neoplasms by Site
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Neurodegenerative Diseases
Neuromuscular Junction Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases
Genetic Diseases, Inborn
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Tocolytic Agents
Reproductive Control Agents
Adrenergic beta-2 Receptor Agonists
Adrenergic beta-Agonists
Adrenergic Agonists
ClinicalTrials.gov processed this record on September 25, 2017


text:
I told my family I don't want anything for Christmas this year.
I lied.
What I said: Because of financial considerations (no money), no one had to buy me anything. And I meant it. Besides, my garage is about to burst with stuff. Not only do I have stuff from a family of five (mine), but I have additional stuff from a couple of other people who have moved to smaller quarters this past year. Sometimes I think, "If only there were a way to make the garage disappear (flamethrower) without harming the rest of the house."
Or someone could buy me an extra garage.
But all this doesn't mean I couldn't use Christmas gifts. I remember making homemade gift certificates as a kid — you know, "Good for one car wash," "Good for one leaf-raking," "Good for one snowmobile oil change," stuff like that. Generally, the adults never collected and thought it was cute. Best of all, I didn't have to spend any of the money I saved up for bi-weekly 96-ounce Slurpees and Hefty bag-size sacks of Doritos. Clearly, dental hygiene was important to me when I was 11.
More than a promise
I would welcome my kids doing the same thing (giving me homemade gift certificates, not eating 74 pounds of Doritos in one sitting). And I would think it was cute. And it would save them money. But unlike other adults, I would totally collect. Just because a kid is cute doesn't mean they shouldn't have to pay up.
Yeah, a gift certificate for washing the dog is fine. But what I really want is one promising that the giver will catch the cat and jam her into her crate the next time she has to go to the vet. I had to do that last time, and I ended up needing more medical care than the cat did.
I certainly would appreciate a written promise to clean the fish tank upon demand. But what I really want is one saying that the giver will dig me a large pond in the yard for the water-based reptiles I'll ask for on my birthday.
A gift certificate for one bathroom cleaning would be fine. But I would really prefer a written promise from all my kids that, for one year, no one will announce what they're about to do when they enter my bathroom. Seriously, do you think that only little boys do that? Girls are just as bad, only the laughter is higher-pitched.
Vacuuming the carpet and sweeping the kitchen are great. But how about, instead, the kids give me a certificate promising that they will stay quiet for an entire afternoon and let me read. Or, better yet, go to a friend's house for 12 hours and let me have a day with my wife. I love my kids and all, but sometimes I get up in the morning and wonder who that strange woman in my bathroom is.
It's important for modern parents (as opposed to those who are here via time travel) to try to share interests with their kids, which I try to do, even though they are girls and I don't understand them. So maybe for Christmas, they could learn the nuances of NFL football or memorize dialogue from "Caddyshack."
Offering to wash my car is wonderful. But how about learning to fix it? I actually floated this one by one of my girls, who looked at me straight-faced and said, "Good luck with that. You should have had a boy."
Wait until she brings home a boy someday, and I don't let her leave with him until he fixes my car.
Contact Tony Hicks at firstname.lastname@example.com, Facebook.com/bayareanewsgroup.tonyhicks or Twitter.com/insertfoot.