text:
Kuroda to start Sunday against Rays
BALTIMORE -- The Yankees announced an edit to their pitching rotation on Wednesday, slotting Hiroki Kuroda in to face the Rays on Sunday at Tropicana Field.
Kuroda had initially been skipped altogether after Tuesday's rainout against the Orioles, with Chris Capuano listed to make Sunday's start. Capuano will now start Monday against the Astros.
Manager Joe Girardi explained that this will still give extra rest to Kuroda, who last pitched on Aug. 10 against the Indians in New York.
"We're trying to stay proactive so he doesn't fatigue down the stretch here," Girardi said.
Kuroda is 7-8 with a 4.03 ERA in 24 starts this season and tired down the stretch last year, when he was 0-6 with a 6.56 ERA in his final eight starts. He said that an extra day here or there could make a difference for him.
"It's really hard to rest during the course of the season," Kuroda said through an interpreter. "When I'm in the season, it's hard to feel rested. I'm glad that the team or the manager was considerate about giving me a rest."
Kuroda, 39, said that he has made one small concession to last season's August and September tailspin; he has decreased the number of pitches in his side sessions between starts by about 10 pitches, hoping to save those bullets for games.
Girardi said that the Yankees' decision to give Kuroda some extra time is more of a preventative measure than based upon signs of wearing down.
"I think it's really based on what happened last year," Girardi said. "I know his last start wasn't great, but the starts before that have been really good. Like I said, we're trying to stay proactive, we've talked about it. I've been asked about it 1,000 times. So we're trying to be proactive."
Bryan Hoch is a reporter for MLB.com. Follow him on Twitter @bryanhoch and read his MLBlog, Bombers Beat. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Garcia still feeling pain in forearm
VIERA, Fla. -- Right-hander Christian Garcia said he still feels pain in his right forearm and will give it a rest for another week. He has not participated in baseball activities since mid-February.
While he is being shut down, Garcia is doing ultrasound and heating the forearm.
"There is nothing you can do. It's more rest than anything," Garcia said. "We are taking it day by day. I want to feel zero pain and then go from there."
When Garcia is ready to pitch, manager Davey Johnson indicated he would still like to see Garcia as a starter.

subset: commoncrawl


text:
A Study to Compare Two Anti-HIV Drug Combinations
This study has been completed.
Hoffmann-La Roche
Information provided by:
NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov Identifier:
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: January 2001
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to compare 2 anti-HIV drug combinations.
|HIV Infections
|Drug: Ritonavir Drug: Efavirenz Drug: Saquinavir
|Phase 3
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|An Open Label, Randomized, Multicenter Study to Evaluate Fortovase (Saquinavir) SGC QD, Norvir (Ritonavir) QD Plus Two NRTIs Vs Sustiva (Efavirenz) QD Plus Two NRTIs in HIV Infected Patients
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Saquinavir Saquinavir mesylate Efavirenz RitonavirU.S. FDA Resources
Further study details as provided by NIH AIDS Clinical Trials Information Service:
|Estimated Enrollment:
|Study Start Date:
|October 1999
Patients are stratified by HIV RNA: 5,000-75,000 vs greater than 75,000 copies/ml by Amplicor assay. Patients are randomized to two arms. Arm A receives SQV plus RTV plus two NRTIs. Arm B receives EFV plus two NRTIs. Patients must take their dose at approximately the same time every day. Patients have the option of taking daily dose in AM or PM. Patients are evaluated for changes in plasma HIV RNA levels and CD4/CD8 counts and for adverse experiences and laboratory determinations. Evaluations are made every 4-8 weeks until Week 48. Patients continuing beyond Week 48 who reach Weeks 60, 72, 84, and common study closure, will be seen at those weeks.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Patients may be eligible for this study if they:
- Are HIV-positive.
- Have a viral load of at least 5,000 copies/ml and a CD4 cell count of at least 75 cells/mm3.
- Are at least 18.
- Are able to complete the study.
Exclusion Criteria
Patients will not be eligible for this study if they:
- Have taken any anti-HIV medications for more than 2 weeks.
- Are pregnant or breast-feeding.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002447
Show 26 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002447
Show 26 Study Locations
Sponsors and Collaborators
Hoffmann-La Roche
|Principal Investigator:
|JSG Montaner
|Study Chair:
|Ann Collier
|Study Chair:
|Danielle Rouleau
|Study Chair:
|Michael Saag
|Study Chair:
|Paul Volberding
|Study Chair:
|Sharon Walmsley
|Study Chair:
|Nicholas Bellos
|Study Chair:
|Alfred Burnside
|Study Chair:
|Stephen Follansbee
|Study Chair:
|Joseph Gathe
|Study Chair:
|Bruce Hathaway
|Study Chair:
|Margaret Hoffman-Terry
|Study Chair:
|Jazila Mantis
|Study Chair:
|Joseph Masci
|Study Chair:
|Mahmoud Mustafa
|Study Chair:
|John Schrank
|Study Chair:
|Malte Schutz
|Study Chair:
|Leon Smith
More Information
Keywords provided by NIH AIDS Clinical Trials Information Service:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00002447 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 2, 1999
|Last Updated:
|June 23, 2005
Keywords provided by NIH AIDS Clinical Trials Information Service:
Drug Therapy, Combination
HIV Protease Inhibitors
Dosage Forms
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 Enzyme Inducers
Cytochrome P-450 CYP3A Inducers
ClinicalTrials.gov processed this record on September 21, 2017


text:
In a recent issue of the Georgia Dairyfax, Lane O. Ely, professor emeritus, University of Georgia, discusses five areas to focus on in 2013:
- Use your resources wisely. If you have adequate supplies of forage, maximize their use in the ration. Know the quality of your forage and designate higher-quality forages to cows in the first half of lactation.
- Balance rations and feed for production. "One of the biggest mistakes that producers make is feeding for 80 pounds of milk but only getting 60 pounds of milk," Ely says. "This is not only inefficient but contributes to a poor cash flow."
- Milk cows that contribute. "With cull cow prices where they are today, low-producing cows that are not covering their feed cost need to be sold or dried off if they are close to calving. An extra 30 days in the dry lot may be cheaper than 30 days on the lactating ration," Ely says.
- Harvest nutrients in your forage.
- Spend money to help you make money. "In tight economic times, people often quit paying for testing and records by either dropping programs or not having people record data. An old saying, 'If you can't measure it, you can't manage it,' could also be 'If you don't measure it, you can't manage it.'"
For more details, read "Hoping for a Better Next Year," on page 4 in the October, November, December 2012 issue of the Georgia Dairyfax.


text:
Art prints & frames, handmade in England since 1982
Maurits Cornelis Escher (1898 - 1972) was a skilled draughtsman, book illustrator, tapestry designer and muralist, best-known for his prints that reflect his fascination with order, symmetry and spatial logic - including his so-called Impossible Constructions.
During his lifetime he made 448 lithographs, woodcuts and wood engravings, and over 2000 drawings and sketches. He played with architecture, perspective and impossible spaces, and his keen observation of the world around us and the expression of his own fantasies continues to fascinate millions of people all over the world.


text: Manchin wants MTV's 'Buckwild' axed By Staff, wire reports December 7, 2012 Story Share CHARLESTON, W.Va. -- Sen. Joe Manchin, D-W.Va., wants MTV to cancel the Kanawha County-based reality show "Buckwild" that's set to air early next year.Manchin's office said Friday that he sent a letter to the president of the network saying the show profits off "poor decisions of our youth."The senator also said the show, scheduled to begin airing Jan. 3, plays to ugly, inaccurate stereotypes about the people of West Virginia.The network ordered 12 episodes of the show last fall, and a trailer shows the cast drinking and swearing, four-wheeling and fighting, even filling a dump truck with water and using it as a swimming pool. It was shot in Sissonville and Charleston.An MTV spokeswoman said Friday that the network had no comment.However, Entertainment Weekly talked to 'Buckwild' producer John Stevens, who said the show "celebrates the youths in a very positive way." Viewers, he told the magazine, will "watch the show and wish they could be them."It's not like looking at a train wreck," Stevens told Entertainment Weekly. "That's not what it is. That's the part I'm really excited about. There is a certain coolness to it. It's different than a lot of the stuff that has been produced. I think it's going to get people talking and it might change people's perspectives. These kids are totally wild and carefree. It will be very refreshing to the MTV audience."Manchin is not alone in his concern for how the show might portray West Virginia. When the trailer was released late last month, Charleston Convention and Visitor's Bureau President and CEO Alisa Bailey told the Gazette-Mail it was "just most unfortunate." The West Virginia Film Office, which can offer tax credits of up to 31 percent to film and TV productions in the state, denied the credits over concerns about negative portrayals of state residents.Bailey had said these kinds of reality shows tend to sensationalize and exaggerate, and she hopes people watching "Buckwild" at home will not view it as how West Virginians really live.Stevens told Entertainment Weekly that the show's appeal "comes from the fact these teenagers are free from technology and the pull of social media."Melissa Whitman, a resident of Beechwood Drive in South Charleston, told the Gazette-Mail this week that several scenes for "Buckwild" were shot last spring in and around a yellow house just across the street.For a reality show, a lot of the filming looked faked, she said, adding that she watched the cast and crew reshoot and tweak scenes."Of course it was made up," she said. "All of this was coaxed, coerced, scripted or whatever." The show will fill the timeslot that had been held by "Jersey Shore." Story Share Story Share Trending Now 1 Deer in 8 WV counties found dead from EHD 2 New company planning $73M synthetic fuel plant in Greenbrier County 3 WVU law professor announces run for Congress 4 Morgantown coal operator Laurita indicted in alleged campaign finance scheme 5 Vietnam veteran builds prosthetics in war zones U.S. Supreme Court to take up same-sex marriage cases Previous Story Clarksburg man gets big check from state treasurer Next Story


text:
Lea Michele has the look of love! The Glee star recently stepped out wearing beau Cory Monteith's name around her neck on a dainty gold nameplate. She certainly isn't the first star to sport "boyfriend jewelry"—Jennifer Aniston and Jessica Biel have also worked their famous Justin's names into precious bling—which made us wonder: Would you wear your beau's name on a necklace? Tell us in the poll below!
If you answered yes, shop our favorite boyfriend jewelry here!
• Cory Talks Love and Lea at the SAGs
• Jess and Justin Hit Up London Fashion Week
• Selena's Justin Bieber Ring (Tear!)


text:
ST. PETERSBURG — An injury to Ben Zobrist will force the Rays to shuffle their roster plans, and further changes may be coming as a verdict on Rocco Baldelli's status nears.
Zobrist, making an impressive transition to super utility man, fractured the tip of his left thumb and will be out about a month, making Andy Cannizaro the apparent frontrunner to be the backup shortstop on the opening day roster.
Whether Baldelli is on that roster is a much larger question, and Rays executive vice president Andrew Friedman said Monday there may be clarity soon: "I would anticipate by the middle of the week to have more of an update to really try to make heads of this."
What that could mean is this: Baldelli's status is no longer a day-to-day proposition — either he says he feels well enough to start playing again, or, seemingly more likely, he doesn't and the Rays start making plans to at least open the season without him.
"The point's coming pretty soon where we're going to need to get him out on the field and get a clear sense of what we can expect in April and beyond," Friedman said. "We're not there yet — we still have 18 days of spring training left to figure these things out — but it's fast approaching."
Baldelli has not played since last Tuesday due to unspecified issues with muscles in his legs, and the Rays agreed to give him until today to see how he felt and reassess. Friedman said it was not "impossible" Baldelli could at least DH in a game this week but was not "probable," either.
From what Baldelli said earlier Monday, it didn't sound like he would be playing anytime soon.
"As far as a timeline, I don't have a timeline," he told the Bradenton Herald. "I'm trying to get to the point where my body feels good and I can go out there and not have to worry about it. I've been having trouble getting to that point, so that's the reason for the extended time off."
But he may be running out of time, as the Rays need to see him in action soon to know what to expect in April. "I think the only way all of us, including Rocco, can get a good feel for that is if we can get him on the field and see how he does and how he feels and kind of get him back into a fairly regular routine of playing," Friedman said.
If Baldelli is unavailable, and Cliff Floyd is used primarily as a DH, the Rays may be in the market for another outfielder to share rightfield with Jonny Gomes and create needed depth, either via trade or by signing a free agent (Kenny Lofton? Barry Bonds?). They are also considering three in-camp candidates: John Rodriguez, Justin Ruggiano and Jon Weber.
"Just like any position on the field, we're lining up different options and different scenarios and different ways we can go," Friedman said, "but it's difficult to be proactive on it right now."
The Rays had big plans for Zobrist, who sustained a hairline fracture of his left thumb while sliding in Sunday's game. Cannizaro, who has played in 13 big-league games, is the likely replacement since none of the other projected infielders (Willy Aybar, Joel Guzman, Akinori Iwamura) can back up shortstop Jason Bartlett. They could also consider prospect Reid Brignac.
Marc Topkin can be reached at firstname.lastname@example.com.


text:
So, I go back out to the field this AM and did some standstill work masterbeato's instructional video. After a few rounds of tries, I amazed myself--I was able to throw a few 375' throws with no run up!
All I did differently was 1) Tried my hardest to keep the disc close to my chest; 2) Keep my weight waaaaay forward over my plant foot; 3) Focus on hip acceleration in the first part and then arm accel later (must do a better job in this); 4) Grip strength. Those four things transformed my throw with a run up from 340' to one without it to 375' with the same disc!
Just amazing that small things like this can make such a large difference. Now all I have to do is keep practicing...


text:
The oremus Bible Browser is, and always has been, offered free of any charge. If you would like to make a contribution to costs then donations of Amazon gift vouchers are a convenient method. These can be purchased online at Amazon UK for delivery by email to email@example.com
Please use amazon.co.uk when buying vouchers; if you use amazon.com then it costs $12.50 to ship each and every book purchased.
At version 2.2.6 (June 2010) we have made a few minor changes to the formatting of the oremus Bible Browser when displayed on iOS devices (such as the iPhone and iPod touch) as well as on other mobile devices. These changes should make it significantly simpler and easier to use the oremus Bible Browser on such devices. Further improvements are also planned. Whilst it is not possible to implement the oBB as an iOS 'app', both for practical and copyright reasons, we do intend to provide an optimized web version for this platform.
In normal usage the oremus Bible Browser does not use cookies at all. However, if you choose to customize the default settings of the oBB (through the Set preferences button, then your choices will be saved in a cookie that is saved to your computer and is read whenever you visit the oBB. The cookie only stores information about your default preferences and is not used to track your usage of the site, and no information is passed to third parties. Third party cookies are not used at all.
Version 2.2 has a new feature which allows you to dynamically toggle the display of verse and chapter numbers, footnote markers, and section headings after you have displayed a bible passage rather than having to decide in advance. These buttons will not remove these text elements if the text is copied from some web browsers into, say, a text editor. To do this click the 'Remove hidden text' button after clicking the required checkboxes, before copying text to the clipboard.
The dynamic toggling of footnotes, verse numbers etc continues to be troublesome in some web browsers when copying and pasting to some word processors. Version 2.2.5 provides a checkbox which when ticked means that any 'hidden' text (as determined by the other hide/show checkboxes) is never written when displaying the specified passage(s). This may make it easier to copy and paste text from the oremus Bible Browser; but the consequence is that the dynamic toggle buttons do not work in this case.
We will be adding more new features in the coming months. Please do write to us at the following address with suggestions for enhancements.
Simon Kershaw <firstname.lastname@example.com>
2 March 2008
v 2.2.7
10 February 2011


text:
Happy New Year? Why, 85-year-old Ann Tompkins is just happy with a new knee.
There's nothing like a festive occasion to bring out the storytelling of Vallejo's "mature" population, especially when it's the annual joyous "Noon Year's Eve Celebration" at the Florence Douglas Senior Center.
About 150 gathered Friday for a Chinese food buffet as center director Vickie Conrad led the New Year's countdown with Larry Critchfield on vocals and Darryl Edwards on keyboard for "Auld Lang Syne."
The tradition began about 15 years ago, said Conrad, "and they love it. You don't have to be out at midnight. You can have a little champagne and you don't have to worry about driving in the dark."
Because the center is typically closed on weekends, New Year's Eve and New Year's Day, the "Noon Year" fun started a little early this time around. And nobody seemed to mind.
"It's fun being with the people here, just enjoying their company," said volunteer Gordon Triembert, promising to continue volunteering in 2013 "because it helps other people which helps us."
Edwards said New Year's -- or any day -- should be a day to honor the seniors.
"I think they're especially special and that we definitely need to bring in every day with our elderly," Edwards said. "Think about where they have come from, the contributions they have made over the years and have paved the way for a lot of us for a better America, better Vallejo and a better world. Give back to them. It's the least we can do to celebrate."
Volunteer server Morgan Diaz said it was fun seeing the seniors happy "and enjoying their time here. They really like champagne."
One other volunteering some time, Mandy Flowers, 70, said the early New Year's is good for the local seniors.
"If they love it, I do too," Flowers said. "I'm thankful to be around a good group of people."
Though Flowers "just likes to be around family and friends" on New Year's Eve, those younger days were a different story.
Not that Flowers remembers.
"I was too wild," she said, grinning. "They were fun."
Shirley Moore has attended years of the early New Year's at the senior center, calling it a "beautiful" gathering.
As for any special memories of New Year's past, Moore said a trip to the MGM Grand in Reno sparks fond times.
"When my husband was alive, we used to go out and party," Moore said.
And New Year's growing up in Kansas?
"I don't remember," Moore said. "That's too many years ago."
Beyond a new knee, Tompkins can't wait for 2013 because "3" is her lucky number.
As for the real New Year's Eve, she'll probably hang around and play cards with friends and do the "New York New Year's" by celebrating at 9 p.m. Monday.
Critchfield, 65, is used to staying up late New Year's, having worked restaurants and clubs many years "watching other people having fun."
Now it's his turn. Surrounded by women Friday, he couldn't wait for the next dance.
"I love it. They're the majority. I got the odds," Critchfield said.


text:
Website of the Day: Giftah
Did you get any gift cards for Christmas that you have no intentions of using? It's OK, you're not stuck with them and you won't have to force yourself to "find something you like." Why, because there's a new site called Giftah that makes it easy for US and Canadian residents to trade or sell their unwanted and unused gift cards. I found this site on Lifehacker, and was skeptical at first, but then soon realized it's actually a nifty site. If you are looking for a bargain, there's some gift cards that are marked down as much as 50 percent from the actual price (usually cards with expiry dates). I'm just wondering what the success rate has been on these transactions so far?
To learn how to post your favorite websites to our Website of the Day group,
I know that this long list looks scary, but trust me, once you get the hang of it, it'll be a snap the second time around.
- First of all, join the Website of the Day group.
- Click the pink "Share" menu on the top left side of the page.
- Choose "Blog" and "Regular Post."
- Give your story a "Title."
- Fill in the "Body" with a link to your favorite website and the reasons why you love it.
- Click "Next."
- Choose the audience for your story to "Website of the Day" in the dropdown menu.
- Add keyword(s) (for example mine for this photo was "Website of the Day").
- Change channel to "Technology and Gadgets."
- Fill in tag field with relevant tags.
- Click "I'm done" to submit content.
So join the Website of the Day group and share information about all your favorite sites! Yours just might end up on the geeksugar homepage!


text:
SAN FRANCISCO — Josh Donaldson drove in a pair of runs with a double and a triple and Josh Reddick hit a two-run homer Thursday night to lead the A's to a 4-0 victory over the Giants in the first game of the Bay Bridge Series at AT&T Park.
Left-hander Scott Kazmir pitched 5 1/3 innings of shutout ball for Oakland, allowing just two hits and three walks. He struck out four. Four A's pitchers limited the Giants to just four hits.
Donaldson drove home Oakland's first run in the third with a double into the corner against San Francisco starter Tim Hudson. In the fifth, after Eric Sogard singled and was sacrificed to second, Donaldson hit a sinking liner to left that got by a diving Michael Morse for a triple.
In the sixth, Hudson surrendered a one-out single to Yoenis Cespedes, who went 2 for 4 with a double, and Reddick followed with a shot into the right field seats. In the bottom half of the inning, Reddick also made a great running catch of a Pablo Sandoval blast at the fence in right-center field.
Hudson pitched six innings and allowed six hits, one walk and struck out six in his first AT&T outing in a Giants uniform. Morse, meanwhile, went 1 for 3 and also dropped a lazy fly ball on his first left field chance for an error.


text:
Categories: Magazines » Other Magazines
UNCUT - September 2012
English | 132 pages | HQ PDF | 137.00 Mb
UNCUT is the UK's most authoritative music and film magazine and every month celebrates the great legends, icons and maverick talents of rock and movies in one brilliant package that embraces both old and new, cult and classic. It is essential reading for anyone with a passion for music and film - and every month there's a free CD.
UNCUT - September 2012 (HQ PDF)
Free 300 GB with Full DSL-Broadband Speed!
Download Rapidgator.net
Download Letitbit.net


text:
Its absolutely fair because after the fact there is nothing more than could happen to decide the outcome. The last shot is the last shot. You are letting perfect be the enemy of good. Its not a perfect solution and it doesn't aim to be, it only ensures that the final shot in a close game is fair for both teams.This quote is hidden because you are ignoring this member. Show Quote
Your point here is entirely irrelevant because the league already scrutinizes certain calls in the game via official review inside 2 minutes. This is just expanding on that. The league has already confirmed that calls in the final 2 minutes are important enough to review in certain situations. The last shot should be one of those. It protects the integrity of the game.


text:
The car was invented to get commuters directly from point A to point B, which made life easier but destroyed the once-thriving tourism industry of point C. Visit all points on the map with this Groupon.
Choose from Four Options
- $39 for a Silver detailing package, which includes a full interior detail (an $89 value)
- $69 for a Bronze detailing package, which includes an exterior wash and a three-step buff and polish (a $139 value)
- $87 for a Gold basic detailing package, which includes an interior cleaning and an exterior wash and wax with tire and rim scrub (a $174 value)
- $99 for a Platinum detailing package, which includes a full interior and exterior detail (a $249 value)
All options include a complimentary Scotchgard service and carpet dye for stains.
Top Gun Auto Detail
Attention to detail has two meanings at Top Gun Auto Detail. It describes both the shop's staff and the praise cars receive after being cleaned so meticulously. During interior detailing services, technicians tidy dashboards, consoles, steering wheels, and trunks. Armed with products by 3M and Malco, they shampoo upholstery and condition leather and vinyl, making it as soft and smooth as a kitten playing a soprano saxophone. Exterior services range from washing and hand waxing to headlight restoration and light bodywork.


text:
A new parent wants to know how to avoid spoiling her baby. Advice blogger Miriam Steinberg-Egeth offers her opinion.
Dear Miriam,
All the parenting books say that you can't spoil a baby before he or she is three months old. My baby is three months old today. What parenting traps should I avoid so that I don't start spoiling her now?
Spoiler Alert
Dear Spoiler,
I could consult a bunch of parenting books in order to respond to your question, but those are just the resources that got you in this situation in the first place. Plus, I have a newborn sleeping against my leg on the couch and a 2-year-old just barely asleep at her crib, so I risk waking these babes if I get up to do some research. Spoiled, you say? One parent's spoiled is another one's typical Tuesday night. Also, I don't have any parenting books.
After that intro, I'm sure my advice is really going to count for a lot here, so I'll continue. My understanding of that three month cut off is that it stems from the idea that, typically, babies are big enough at three months to be able to go longer stretches of time without eating. Once a baby can go longer without eating, the thinking goes, you don't have to respond every time he wakes up at night. If you don't have to respond to every cry at night, then you also don't have to respond immediately during the day. If you don't respond immediately during the day either, your baby will learn to be more self-sufficient. If your baby is more self-sufficient, he won't rely on you as desperately for comfort and entertainment. If he isn't entirely reliant on you for comfort/entertainment, then your baby won't end up spoiled. Dayenu.
I have no idea if any of this is true, and my husband and I haven't been compelled to test the theory. Our two-year-old loves us and needs us and knows we're there for her. When we can't immediately pick her up or attend to her, we explain why (I have to turn on the oven, and it's not safe for you to be near it; it's 4:00 a.m., and that's too early to get up; or, more recently, the baby needs to eat now, but I'll play with you when he's done.) We set boundaries, particularly around safety, but when we can attend to her, we do. She's only two, and "spoiled" to me really connotes a five-year-old in the grocery store begging for and receiving candy. Fortunately, we're not in that territory yet, and we don't forsee succumbing to that type of demand.
The older a kid gets, the more you can reason with her, but a three-month-old, or even a six- or nine-month-old doesn't understand why you're not responding, just that you're not. I already see that sometimes my newborn is going to cry for longer periods of time before immediately being picked up, but it feels different to me when it's out of circumstance/necessity rather than to make a point or stave off some amorphous "spoilage." All that being said, as with basically anything about parenting, I think you have to do what works for you. If you are a competant and caring parent, your child will be safe and loved, and the incremental decisions that drive parents nuts in the moment don't matter so much in the big picture. As for more tangible tips, I do agree with the parenting advice that suggests putting your baby down while drowsy rather than asleep (the baby, not you), and I think some sleep training is necessary if you ever want to sleep through the night again, but it doesn't have to involve "ferberizing," and it certainly doesn't have to be at three months old. Yes, those two pieces of advice are about sleep, because that's actually the only thing that matters.
If you want to find a source that confirms or denies essentially anything you want confirmed or denied and you're not happy with your current set of parenting books, try google. Whatever you're doing, someone else has tried it lots of people have opinions on it. Then again, I've also heard that you shouldn't trust anything you read online.
Be well,


text:
Product Summary
ZebraCare Depot standard back-to-factory agreements cover all the labor and parts required to keep your printers operating at the high performance levels you have come to expect from your Zebra products. All Zebra equipment returned for service under this agreement will receive a complete preventative maintenance procedure and will be returned to you at no additional cost.
General Information
|Product Type
|Manufacturer Part Number
|Manufacturer Website Address
|Service Name
|Zebra Technologies Corporation
|Brand Name
Service Information
|Product Supported
Zebra MZ220 Printer
|Service Details
|Service Duration
|1 Year
|Service Main Type
|Service Sub Type
|Service Characteristic
|Parts & Labor
|Service Response Time
|5 Day
This product is shipped only within Canada and Warranty valid for Canada only.
Computer Valley makes every effort to provide accurate specifications, descriptions, images and price on all products that are found on www.computervalley.ca
However for complete and updated descriptions, compatibilities, specifications and actual photo we recommend our clients to consult with manufacturer's websites or simply call us for proper clarifications. Computer Valley is not responsible and will not accept returns for items purchased that are not compatible with your system. Please ensure that you have verified compatibility and actual photo with your system by visiting the manufacturer's web site prior to purchase or give us a call to make sure what you are purchasing.
For more information, visit our Shipping and Return policy.
Computer Valley wants to provide you with the best and fastest possible service. We try to ship in stock orders placed before 2:00pm EST the same day. For in stock orders placed after 2:00pm EST they are usually shipped the next business day. However there are always exceptions. Please contact us prior to placing your order if you need your purchase by a certain date.
We ship by UPS, FEDEX, USPS, CANADA POST , PUROLATOR and LOOMIS from the nearest locations possible based on stock in hand.
Please note: Computer Valley reserves the rights to accept and cancel any order at anytime due to pricing error or any other reason. An email will be sent as a confirmation of the order status.
|Read Reviews Write Review


text: This news item expired on Thursday, January 31, 2013 so the information below could be outdated or incorrect. Don't miss the video link at the bottom of the page! Lawns: Use this time to get the mower into the shop for a tune up and sharpening. You should be able to take a break from the lawn the rest of the month. Ornamentals: This is a good time to do selective pruning on shade trees. Make a clean cut at the branch collar. See Trees, Flush Cuts and Wound Dressings. Cut back ornamental grasses, as well as liriope and mondo grass, before spring growth begins. Inspect house plants for insect infestations such as spider mites, scales and whiteflies. Fruits: Plant fruit trees, grape vines and brambles. Prune grape vines and highbush blueberries. Videos on pruning are available for loan from the Extension office. Just call 255-5522. It is best not to prune fruit trees until March, especially peaches. Vegetables: Start your garden plan on paper as you browse the garden catalogs. This will help prevent ordering more than you have room to plant. After checking your seed inventory, make a list and place seed orders for things you may not be able to find locally. When the soil dries out enough to work, go ahead and prepare a spot for the late February planting of peas and kale. If you are maintaining winter vegetables in a greenhouse or under plastic tunnels, remember that venting on sunny days will be important to prevent over-heating. Other: Clean out bird houses and put up new ones. Bluebirds and some other songbirds start scouting for spring nest boxes in February. Use deicing salt sparingly. Sweep excess salt off the pavement as soon as it has dried. Some newer salt products are less damaging to plants, but still need to be used with care. For more information, view BCTV's January Garden Chores video with host Linda Blue, or call Buncombe County Cooperative Extension at 255-5522.


text:
A GWENT MP launched a stinging attack on his own Conservative-led coalition over what he describes as "incompetence of the highest levels of government".
David Davies, who represents the Monmouth constituency, accused his own party of being out of touch with the electorate and said the Prime Minister David Cameron needs to listen more if the Tories were to recover losses suffered in the local elections.
In a letter to the Argus, the Tory backbencher apologised to those who felt they had been let them down - a factor which he says has seen some voters, including his own mother Kath, turn to the UK Independence Party instead.
He said loyal Conservative voters expected certain things from the party such as a balanced budget and a tough stance on immigration and crime.
But he believes issues including the government's failure to overcome human rights laws to deport extremist Islamic clerics like Abu Qatada, have been sidelined for talks over proposed changes to gay marriage laws and House of Lords reform.
Instead Mr Davies wants to see a reduced spend on foreign aid while taxes here are going up and cuts are being made to police forces.
He also wants a referendum on Britain's membership of the European Union and the European Court of Human Rights and believes a cabinet reshuffle is needed. He said: "The British Government needs to look after Britain first.
"David Cameron needs to change his tact very rapidly other wise he's not going to be in position for very long. "I am sure he realises his supporters are not happy with what's going on."
"If I sound like I'm being critical I am. I have been a been loyal for the last couple of years, although I have voted against the government on certain things like the EU referendum question, but there comes a point when it is becoming more difficult to remain so loyal."
His comments came on the day the Queen makes her speech to parliament outlining the government's plans for the coming parliamentary year.
EDITORIAL COMMENT: Is Cameron on thin ice?
MONMOUTH MP David Davies is not known for hiding his light under a bushel.
It should come as no surprise the Conservative backbencher has forthright views about the difficulties that have enveloped the coalition government in recent weeks.
But it is significant Mr Davies feels compelled to write to this newspaper to apologise to his constituents for what he calls "incompetence at the highest levels of government".
Mr Davies says he has been loyal to David Cameron but "it is becoming more difficult to remain so loyal".
If other Tory backbenchers share Mr Davies' views then the prime minister could be in real trouble.
There is little doubt many Tory MPs are growing uneasy with the coalition, believing the Liberal Democrats are holding them back from being a 'proper' Conservative government.
The only way of changing that situation, of course, is to go back to the country.
And there are clearly some Tory MPs, like Mr Davies, who doubt whether Mr Cameron is the man to lead them into the next election.
The Conservatives are renowned for ruthlessly dispatching leaders they believe to be election liabilities.
Margaret Thatcher was axed after 11 years in Downing Street; Ian Duncan Smith got the boot before he had the chance to fight an election.
Is Mr Cameron next on the list for the men in grey suits?


text:
Effect of Distal Needling on Knee Pain Using Acupuncture Techniques
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2012 by Elad Davidson, Hadassah Medical Organization.
Recruitment status was: Not yet recruiting
Recruitment status was: Not yet recruiting
Hadassah Medical Organization
Information provided by (Responsible Party):
Elad Davidson, Hadassah Medical Organization
ClinicalTrials.gov Identifier:
First received: June 3, 2012
Last updated: June 5, 2012
Last verified: May 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to test if specific therapeutic benefits of acupuncture are mostly attributable to contextual and psychosocial factors, such as patients' beliefs and expectations.The investigators propose using the 2 acupuncture methods, which refrains from inserting needles in the affected area, in order to evaluate the short-term and long-term efficacy of acupuncture in a clinical setting compared with placebo and compared with invasive needling that does not adhere to "correct" acupuncture rules.
|Patellar Tendonitis Complete Tear, Knee, Anterior Cruciate Ligament
|Device: Pain relief by Acupuncture needle at non-specific site Device: Acupuncture needle
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
|Official Title:
|Comparison of Different Acupuncture Methods on Knee Pain
Resource links provided by NLM:
MedlinePlus related topics: AcupunctureU.S. FDA Resources
Further study details as provided by Elad Davidson, Hadassah Medical Organization:
Primary Outcome Measures:
- Effect of Distal Needling on Knee Pain Using Acupuncture Techniques [ Time Frame: 2 years ]
Effect of Distal Needling on Knee Pain Using 4 different Acupuncture Techniques by:
- Pain measurement by Visual Analogue Scale (VAS)
- Range of motion (ROM)
|Estimated Enrollment:
|Study Start Date:
|June 2012
|Estimated Study Completion Date:
|June 2015
|Estimated Primary Completion Date:
|June 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Active Comparator: deep needle non-site specific
|Device: Pain relief by Acupuncture needle at non-specific site
|Active Comparator: contralateral elbow to the knee pain
|Device: Acupuncture needle
|Active Comparator: Energy of Living Systems Needling
|Device: Acupuncture needle
|Placebo Comparator: Sham acupuncture
|Device: Acupuncture needle
Detailed Description:
The main novel features of this study:
- First aim to assess the effect of distal needling on knee pain
- Second aim to directly compare two acupuncture techniques, placebo, needling at "wrong" places and "correct" needling for knee pain
Advantages of the study compared to published data:
- Distal needling - enables assessment of range of motion (ROM) and pain level during needling.
- Both acupuncture systems rely on minimal questioning, which simplifies the patient-practitioner interactions.
- Exploratory studies in the clinic of DP show that it is possible to distinguish between "correct" and "incorrect" needling, at least in the short term. Long term effects have not been assessed yet.
|Ages Eligible for Study:
|18 Years to 85 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Adult patients (> 18 years old), suffering chronic stable pain score >40 mm on 100 mm VAS of the knee due to patellar tendonitis.
- Patients have had X-rays or other tests confirming they are not candidates for surgery nor are scheduled for steroid injections or hyaluronic acid injections within 8 weeks from the beginning of the study.
- Adult patients (> 18 years old), two weeks after ACL reconstruction surgery (with or without meniscal involvement), with pain score >40 mm on 100 mm VAS of the knee (all patients at this stage have significant ROM limitation).
Exclusion Criteria:
- Patient refusal
- Soldiers
- Pregnancy
- Morbid obesity
- Diabetes
- Peripheral vascular disease
- Lower limb neurological deficit (such as multiple sclerosis, nerve palsy), other serious co-morbidity (including severe back pain or hip pain)
- A history of prolonged or current steroid use
- Received hyaluronic acid injections within the previous 3 months
- Have needle phobia or allergy to sticking plaster.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01612663
Please refer to this study by its ClinicalTrials.gov identifier: NCT01612663
|Contact: Hadas Lemberg, PhD
|00 972 2 6777572
|Hadassah Medical Organization
|Not yet recruiting
|Jerusalem, Please select, Israel, 91120
|Contact: Hadas Lemberg, PHD 972 507874098 firstname.lastname@example.com
|Contact: Elyad Davidson, MD 972 507874098 email@example.com
|Principal Investigator: Adi Friedman, MD
|Hadassah Medical Organization
|Not yet recruiting
|Jerusalem, Please select, Israel, 91120
|Contact: Adi Friedman, MD 972 507874778
Sponsors and Collaborators
Hadassah Medical Organization
|Principal Investigator:
|Elyad Davidson, MD
|Hadassah Medical Organization
More Information
Keywords provided by Elad Davidson, Hadassah Medical Organization:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Elad Davidson, PI Head Pain Unit, Hadassah Medical Organization
|ClinicalTrials.gov Identifier:
|NCT01612663 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 3, 2012
|Last Updated:
|June 5, 2012
Keywords provided by Elad Davidson, Hadassah Medical Organization:
Knee pain
Sham acupuncture
Additional relevant MeSH terms:
Muscular Diseases
Musculoskeletal Diseases
Tendon Injuries
Wounds and Injuries
ClinicalTrials.gov processed this record on September 21, 2017


text:
select a format
Recent Viewed Reports
Why Ken Reasearch?
This is with regards to your report on India PVC pipes and fitting market outlook industry outlook to 2019. This is a very well written report and accept my compliments on the same.... ... "Mohit Mittal, Consultant, KPMG Advisory Services"
I am pleased to see the very useful and productive information in the report..Very well structured great presentation reflect professionalism in your research studies.... "Mustafa Masood, Financial Analyst , Coldwell Banker Riyadh"
While we still are studying and analysing your reports about Vietnam & Thailand, we would like to convey to your research team that they have done a very good job in compiling so much of information together. We hope to see more of such well researched reports. All the best & keep it up. ... "Prashant Bhagwat,General Manager, Mahindra"
We would like to appreciate Ken Research for their great efforts and wonderful support in providing the Market Intelligence Report for ITPC. The information, statistics and research are well understandable and very clear to the point. We are happy with Ken research for their good client service, on-time delivery of the report and as said the report itself. Thank you Ken research for bringing the valuable output for us. We would be looking forward to have more research with you in the near future. Wish you a success in your business!... "Jestin Mathew, Indonesian Trade Promotion Center"
The Report was very interesting and useful for me... "Marketing Manager, Western Union Business Solutions"
Executive Summary
Orient Pharma Co Ltd (Oripharm) is a pharmaceutical company that manufactures and distributes drugs for various therapeutic areas. The company develops drugs for anti-psychotics, Alzheimer's disease, psychostimulants and Parkinson's disease. Its drug delivery technologies comprise multi stages controlled release technology, trans dermal patches, oral disintegrating tablets, sustained release technology and microgranules. Oripharm offers clinical research and regulatory affairs services. The company also provides advices on clinical study strategies and health authorities' requirements. It partners with research and development oriented companies from the European union, Taiwan, the US and Japan. Oripharm is headquartered in Taipei, Taiwan.
This comprehensive SWOT profile of Orient Pharma Co Ltd provides you an in-depth strategic analysis of the company's businesses and operations. The profile has been compiled by GlobalData to bring to you a clear and an unbiased view of the company's key strengths and weaknesses and the potential opportunities and threats. The profile helps you formulate strategies that augment your business by enabling you to understand your partners, customers and competitors better.
This company report forms part of GlobalData's 'Profile on Demand' service, covering over 50,000 of the world's leading companies. Once purchased, GlobalData's highly qualified team of company analysts will comprehensively research and author a full financial and strategic analysis of Orient Pharma Co Ltd including a detailed SWOT analysis, and deliver this direct to you in pdf format within two business days. (excluding weekends).
The profile contains critical company information including*,
Business description-A detailed description of the company's operations and business divisions.
Corporate strategy-Analyst's summarization of the company's business strategy.
SWOT Analysis-A detailed analysis of the company's strengths, weakness, opportunities and threats.
Company history-Progression of key events associated with the company.
Major products and services-A list of major products, services and brands of the company.
Key competitors-A list of key competitors to the company.
Key employees-A list of the key executives of the company.
Executive biographies-A brief summary of the executives' employment history.
Key operational heads-A list of personnel heading key departments/functions.
Important locations and subsidiaries-A list and contact details of key locations and subsidiaries of the company.
Key manufacturing facilities-A list of key manufacturing facilities of the company.
Detailed financial ratios for the past five years-The latest financial ratios derived from the annual financial statements published by the company with 5 years history.
Interim ratios for the last five interim periods-The latest financial ratios derived from the quarterly/semi-annual financial statements published by the company for 5 interims history.
Note*: Some sections may be missing if data is unavailable for the company.
Key benefits of buying this profile include,
You get detailed information about the company and its operations to identify potential customers and suppliers.
The profile analyzes the company's business structure, operations, major products and services, prospects, locations and subsidiaries, key executives and their biographies and key competitors.
Understand and respond to your competitors' business structure and strategies, and capitalize on their weaknesses. Stay up to date on the major developments affecting the company.
The company's core strengths and weaknesses and areas of development or decline are analyzed and presented in the profile objectively. Recent developments in the company covered in the profile help you track important events.
Equip yourself with information that enables you to sharpen your strategies and transform your operations profitably.
Opportunities that the company can explore and exploit are sized up and its growth potential assessed in the profile. Competitive and/or technological threats are highlighted.
Scout for potential investments and acquisition targets, with detailed insight into the companies' strategic, financial and operational performance.
Financial ratio presented for major public companies in the profile include the revenue trends, profitability, growth, margins and returns, liquidity and leverage, financial position and efficiency ratios.
Gain key insights into the company for academic or business research.
Key elements such as SWOT analysis, corporate strategy and financial ratios and charts are incorporated in the profile to assist your academic or business research needs.
Contact Us:
Ken Research
Ankur Gupta, Head Marketing & Communications
ankur [@] kenresearch.com
Table of Contents
Section 1-About the Company
Orient Pharma Co Ltd-Key Information
Orient Pharma Co Ltd-Overview
Orient Pharma Co Ltd-Key Employees
Orient Pharma Co Ltd-Key Employee Biographies
Orient Pharma Co Ltd-Key Operational Heads
Orient Pharma Co Ltd-Major Products and Services
Orient Pharma Co Ltd-History
Orient Pharma Co Ltd-Company Statement
Orient Pharma Co Ltd-Locations And Subsidiaries
Orient Pharma Co Ltd-Key Manufacturing facilities
Head Office
Other Locations & Subsidiaries
Section 2-Company Analysis
Orient Pharma Co Ltd-Business Description
Orient Pharma Co Ltd-Corporate Strategy
Orient Pharma Co Ltd-SWOT Analysis
SWOT Analysis-Overview
Orient Pharma Co Ltd-Strengths
Orient Pharma Co Ltd-Weaknesses
Orient Pharma Co Ltd-Opportunities
Orient Pharma Co Ltd-Threats
Orient Pharma Co Ltd-Key Competitors
Section 3-Company Financial Performance Charts
Orient Pharma Co Ltd-Financial Ratios
Financial Ratios-Capital Market Ratios
Financial Ratios-Annual Ratios
Financial Ratios-Interim Ratios
Financial Ratios-Ratio Charts
Section 4-Appendix
Ratio Definitions
About GlobalData
Contact Us
Note*: Some sections may be missing if data is unavailable for the company
List of Figures
Orient Pharma Co Ltd, Performance Chart
Orient Pharma Co Ltd, Ratio Charts
List of Tables
Orient Pharma Co Ltd, Key Information
Orient Pharma Co Ltd, Key Ratios
Orient Pharma Co Ltd, Share Data
Orient Pharma Co Ltd, Major Products and Services
Orient Pharma Co Ltd, History
Orient Pharma Co Ltd, Key Employees
Orient Pharma Co Ltd, Key Employee Biographies
Orient Pharma Co Ltd, Key Operational Heads
Orient Pharma Co Ltd, Other Locations
Orient Pharma Co Ltd, Subsidiaries
Orient Pharma Co Ltd, Key Manufacturing facilities
Orient Pharma Co Ltd, Key Competitors
Orient Pharma Co Ltd, SWOT Analysis
Orient Pharma Co Ltd, Ratios based on current share price
Orient Pharma Co Ltd, Annual Ratios
Orient Pharma Co Ltd, Interim Ratios
Currency Codes
Capital Market Ratios
Equity Ratios
Profitability Ratios
Cost Ratios
Liquidity Ratios
Leverage Ratios
Efficiency Ratios
Single User License:
Site License:
Corporate User License:
Orient Pharma Co Ltd, SWOT analysis, SWOT, Strengths, Weaknesses, Opportunities, Threats, Corporate Strategy, Key Ratios, Share Data, Performance, Financial Performance, Overview, Business Description, Major Product, Brands, History, Key Employees, Key Operational Heads, Strategy, Key Competitors, Company Statement, Capital Market Ratios, Financial Ratios, Annual Ratios, Interim Ratios, Ratio Charts
Company Brochure


text:
Get an overview of this hotelCasual tropical playground is a family friendly resort.
Popular property highlights
On beach in Old Town
This attractive resort is set among the quaint buildings of Key West's Old Town and features a large private beach. The resort is within walking distance of Duval Street and Southernmost Point.
Pool and beach service
The Reach, A Waldorf Astoria Resort, has a fitness center, an array of water sports, a cafe, and concierge service at the pool and beach, including delivery of fresh fruit and cooling towels.
Furnished balconies
Guestrooms provide balconies with views of the city or ocean. Amenities include wet bars, flat-screen TVs, in-room safes, and MP3 docks. Wireless and wired high-speed Internet are available.
Guest Highlights
- Good location
- Beach
- Pool
- Helpful staff
- Clean guestrooms
- Parking wasn't ideal
The Reach, A Waldorf Astoria Resort
Hotel Amenities
Hotel Amenities
Facilities at The Reach, A Waldorf Astoria Resort, include a private beach, access to a neighboring property's pool, a cafe, a 24-hour fitness center, and on-site rental of bicycles, Jet Skis, sail boats, kayaks, and snorkeling gear. Other activities available nearby include parasailing; excursions for fishing, snorkeling, and scuba diving; and sunset catamaran trips. Pool-side concierge services are included in the resort fee.
The property offers a ballroom, 24-hour business center, and multiple meeting rooms with 4,700 square feet of space. Event catering is available.
- 24-hour front desk
- Babysitting or childcare (surcharge)
- ATM/banking
- Valet parking (surcharge)
- Number of floors - 5
- Bar/lounge
- Breakfast available (surcharge)
- Coffee shop or café
- Free newspapers in lobby
- Elevator/lift
- Concierge services
- Conference space
- 24-hour fitness facilities
- Dry cleaning/laundry service
- Express check-out
- Gift shops or newsstand
- Pool umbrellas
- Tours/ticket assistance
- WiFi (surcharge)
- Limo or Town Car service available
- Meeting rooms 4
- Multilingual staff
- Total number of rooms - 150
- Garden
- Poolside bar
- Porter/bellhop
- Luggage storage
- On private beach
- Restaurant
- 24-hour business center
- Conference space size (feet) - 4706
- Conference space size (meters) - 437
- Number of meeting rooms - 5
- Pool sun loungers
- Shopping on site
- Number of buildings/towers - 1
- Outdoor pool
- Wedding services
Available in all rooms: Free WiFi
Available in some public areas: WiFi (surcharge)
Valet parking (surcharge)
Room Amenities
- Premium TV channels
- Furnished balcony
- In-room climate control (air conditioning)
- Air conditioning
- Ceiling fan
- Phone
- Free bottled water
- Daily housekeeping
- Designer toiletries
- Private bathroom
- Bathrobes
- Free toiletries
- Hair dryer
- Iron/ironing board
- In-room safe
- Cable TV service
- Refrigerator
- Flat-panel TV
- Free WiFi
- Room service (limited hours)
- Connecting/adjoining rooms available
- Free cribs/infant beds
- Espresso maker
Where to Eat
Spencer's By The Sea - Spencer's original innovative menu, is complimented by an extensive wine and cocktail list.
Room service is available.
Nearby Things to Do
The hotel offers direct access to a private, sandy beach and use of a neighboring property's pool. Jet Skis, sailboats, kayaks, paddle boats, "ocean bikes," snorkel gear, scooters, and bicycles are available for rent. Parasailing is available on the beach. From the resort's pier, guests can take snorkeling and scuba-diving excursions, go deep-sea or flats fishing, and sail aboard a catamaran at sunset.
The recreational activities listed below are available either on site or near the hotel; fees may apply.
- Golfing nearby
- Snorkeling nearby
- Surfing/boogie boarding nearby
- Kayaking nearby
- Sailing nearby
- Water skiing nearby
- Personal motorized watercraft on site
- Windsurfing nearby
- Scooter/moped rentals nearby
- Bicycle rentals nearby
- Parasailing nearby
- Skydiving nearby
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- In-room accessibility
- Accessible bathroom
- Roll-in shower
Hotel Policies
Check-in time ends at midnight
Minimum check-in age is 21
Check-in time starts at 4 PM
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Children 18 years old and younger stay free when using existing bedding.
- Rollaway/extra beds are not available.
- Free cribs (infant beds)!
- Pets allowed for an extra charge of USD 75 per accommodation, per night
- Dogs only
- 2 per room (up to 25 lb)
- Specific rooms only
- Pet-friendly rooms can be requested by contacting the property at the number on the booking confirmation
You need to know
Extra-person charges may apply and vary depending on property policy.
- Resort fee: USD 35.00 per accommodation, per night
- Pool access
- Spa access
- Beach access
- Beach loungers
- Beach towels
- Health club access
- Partner property beach club access
- Partner property pool access
- Partner property access
- Nearby fitness center access
- Business center/computer access
- Internet access
- Newspaper
- Phone calls
- Faxes
- In-room safe
- In-room coffee
- In-room bottled water
- Housekeeping
- Additional inclusions
Optional extras
- Breakfast fee: between USD 25 and USD 35 per person (approximately)
- Valet parking fee: USD 35.0 per day (in/out privileges)
- Pet fee: USD 75 per accommodation, per night
- Late check-out fee: USD 50
Hotel Name
- Reach Waldorf Astoria
- Reach Waldorf Astoria Key West
- Reach Waldorf Astoria Resort
- Reach Waldorf Astoria Resort Key West
- The Reach, a Waldorf Astoria Hotel Key West
- Reach Resort Key West
- Waldorf Astoria Key West
We should mention
Children 18 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation. This property allows pets in specific rooms only (surcharges apply and can be found in the Fees section). Guests can request one of these rooms by contacting the property directly, using the contact information on the booking confirmation.
Best of Waldorf Promotion
Book a stay in a "Best of Waldorf" rate plan category and receive the following:
- One $50 USD hotel credit per night, per room


text:
anon. Raider Helmet
Stripped down capabilities and skate inspired function
The men's anon. Raider helmet features Endura-Shell construction for long-lasting durability and strength. The skate-inspired design is multi-season certified in North America and Europe, and incorporates passive ventilation to keep goggles clear and maintain a balanced temperature all day long. The goggle clip is removable for warm weather activities, and the classic fleece on the liner and removable ear pads offers optimal warmth and quick-drying comfort.
- Weight: 595g
- Standard Fit System
Simple Fit
Simple Fit
All Anon helmets feature easily removable ear pads and liners making every model easily convertible for riders who want to run a beanie and goggle under their lid for that skate-inspired, ultra-low-profile look without sacrificing comfort.
Endura-Shell Construction
Endura-Shell Construction
Endura- shell two-piece construction features an injection-molded ABS exterior for long-lasting durability and ding-resistant strength. Built for season after season of knock-around wear and tear, this is the pinnacle in reliable protection.
- Multi-Season Certified in North America & Europe
- ASTM 2040 / CE 1077B / CE 1078:2012 +A1:2012 / CPSC Certified
Passive Ventilation
Passive Ventilation
Passive ventilation channels integrated into the helmet draw fresh air in the front and pulls moisture out the back. These built-in channels help to keep goggles clear and aid in maintaining a balanced and comfortable climate all day long.
- Removable Goggle Clip
Classic Fleece on Liner and Ear Pads
Classic Fleece on Liner and Ear Pads
Designed for optimal warmth and comfort.
- Audio Accessory Compatible
anon. Warranty
anon. Warranty
All Anon products are backed by a one-year warranty from date of purchase. Anon helmets are also backed by a two-year crash replacement policy. Our W48 Warranty Program ensures that should you have a problem, we'll have your claim repaired or replaced and on its way back to you within two business days of receiving it.


text:
Scientists are beginning to unravel the mechanisms behind the therapeutic effects of psychedelic drugs.
How to Make Eyeball Stew
March 1, 2012|
Editor's choice in developmental biology
March 1, 2012|
Editor's choice in developmental biology
March 1, 2012|
With an eye to understanding animal regeneration, Alejandro Sánchez Alvarado has turned a freshwater planarian into a model system to watch.
February 22, 2012|
For the first time researchers have demonstrated the molecular tango that gives rise to repeating patterns in developing animal embryos.
February 9, 2012|
Imaging cell cytoskeletons during early embryonic development leads researchers to uncover a new regulator of cell shape
January 9, 2012|
Brain imaging and gene analyses in twins reveal that white matter integrity is linked to an iron homeostasis gene.
January 1, 2012|
Assistant Professor, Department of Anatomy and Cell Biology, University of Western Ontario. Age: 34
December 1, 2011|
After 6 months in orbit, Caenorhabditis elegans return to Earth—alive and well.
December 1, 2011|
Researchers find that newts are capable of regenerating body parts well into old age.
December 1, 2011|
Full Professor and Senior Research Group Leader, German Center for Neurodegenerative Diseases. Age: 42
December 1, 2011|
Cut off a newt's tail or a leg, or remove a lens from its eye, and it grows back. However, whether newts can continue to do this throughout their lives, or lose the ability as they get older, has remained a mystery.


text:
Updated from 6:05 p.m. ET to include additional commentary on earnings season from Wells Fargo and latest after-hours prices. NEW YORK ( TheStreet) -- Undaunted by all the negative commentary floating around ahead of the third-quarter reporting season? You're not alone. Birinyi Associates pointed out Tuesday that earnings pessimism is nothing new and argued investors have been well-served in the past by blocking out the noise. "While earnings may be a 'bump in the road' for some companies, with correlation at the lowest level since April, there are still opportunities for stocks to outperform going into the end of the year and the overall negative view of upcoming earnings has not been a convincing reason to exit the market over the past two years," the firm said. For example, Birinyi noted there was similar talk ahead of the second-quarter reporting season, and when the smoke cleared, 67% of S&P 500 companies beat expectations, a tad better than the 66% quarterly average seen since 2000. What's more, the S&P 500 rallied to end the calendar third quarter up nearly 6% though Ben Bernanke had a lot to do with that. Birinyi also looked ahead to better expectations for future periods, saying "strategists are still calling for 10.2% earnings growth in 4Q12, 5.5% in FY12 and 10.7% in FY13." All fair points though the year-over-year decline in earnings expected for the third quarter shouldn't just be brushed aside. After all, it's the first backpedaling in profits since the financial crisis and every day seems to bring fresh evidence that weak business conditions in Europe and the relative slowdown of growth in China are being felt stateside. In addition, those bullish forecasts for the fourth quarter, fiscal 2012 and fiscal 2013 may be a lot less rosy after companies finish issuing guidance this time around. There's an argument to be made that the low expectations may be something of a good bad sign for stocks, making it easier for companies to outperform, but let's not forget that declining profits are still declining profits. True believers in equities can take some comfort in the fact that this recent rally isn't the product of excitement about earnings; it comes courtesy your friendly neighborhood Federal Reserve and its promise of maximum accommodation. What's more, valuations for stocks are reasonable by historical standards so while an earnings-inspired rally may not be in offing, a severe pullback also seems like a reach, barring a turn for the worse in Europe or the United States falling off the fiscal cliff. Scott Wren, senior equity strategist at Wells Fargo, is another market watcher that thinks the gloom and doom rhetoric about this earnings season is overdone. "Another earnings reporting season is upon us and the media is out in force warning that the results will likely be disappointing; as if this is novel news the market needs to digest," he said in emailed commentary late Tuesday. "The fact of the matter is most equity strategists have been looking for third quarter earnings to be poor for some time. Despite reports to the contrary, market participants are generally not 'on edge' and 'fearful' about what companies will be saying over the next few weeks. The market, in our opinion, is prepared to a large extent for the overall bad earnings comparisons that are about to be reported."
- Log In
- Newsletters
Access insights and guidance from our Wall Street pros. Find the product that's right for you.
- Action Alerts PLUS
- Daily Swing Trade
- Income Seeker
- Quant Ratings
- Real Money
- Real Money Pro
- Stocks Under $10
- Top Stocks
- Trifecta Stocks
- Real Money Pro Portfolio
- Chairman's Club
- Compare All


text:
found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am housetrained, up to date with shots, good with kids, good with dogs, and good with cats.
If you are interested in meeting and thinking about adoption, please visit our website, http//www.wagginghearts.org, and submit a completed adoption application. Due to the high volume of applications we receive we are only able to process fully completed applications. All applications are processed in the order that they are received. On our website you will also find our adoption process and fees. Since we are a foster based rescue we are unable to set up meet and greets until a completed application is on file and has been approved.
Wagging Hearts is a foster-based, non-profit rescue organization.
Hazel, a Hainesville Collie/Terrier (Unknown Type, Medium) dog was adopted! Here's how you can benefit by looking at adoption as an option to buying a Collie/Terrier (Unknown Type, Medium) for sale in Hainesville, or seeking a Collie/Terrier (Unknown Type, Medium) dog from a breeder in Hainesville.


text:
I have been unable to locate a sahga where I live in NH, I am going to take refuge later this week and have a question. Can I do this alone or do I need someone ordained to guide me?
Peace and happiness,
Return to "General Theravāda discussion"
Users browsing this forum: Bing [Bot] and 18 guests


text:
Are you looking for a subtle way to show off your business? Customize any of our unique travel accessories for employees and customers to take on their next trip! These items are perfect for sporting your logo in hotels, airports, and different cities. ePromos' travel bottles are TSA-approved to gain your brand exposure before boarding. What's more, practical items like neck pillows and travel wallets will upgrade users' in-flight experience. Team up with ePromos, and our corporate gifts will elevate your company's visibility throughout all corners of the world.
Promotional travel kit packed with six bottles for packaging your favorite shampoo, soap and lotions.
Never struggle with filling travel bottles again with the Go Gear Imprinted Travel Bottle.
Never waste a drop of your favorite lotions, soaps, and shampoos with the Go Gear Imprinted Travel Bottle.
A three-piece promotional travel kit that includes a TSA--compliant travel pouch packed with an eye mask and earplugs for great sleep during travel.
Don't waste a drop of your favorite lotions or soaps with the Go Gear Imprinted Travel Bottle.
This promotional toiletry kit is a TSA approved carry on so you can bring your shampoos and company logo with you on the plane.


text:
Judge, United States District Court for the Central District of California
On July 26, 2007, Judge Otis Wright, II '80 was inducted as a judge of the United States District Court for the Central District of California. One of five nominees selected by President George Bush for the federal bench in January, the U.S. Senate confirmed him to the court in March with enthusiastic bipartisan approval.
Several prominent members of the federal bench were on hand to praise Judge Wright, including: the Hon. Alicemarie H. Stotler, Chief Judge of the U.S. District Court for the Central District of California, the Hon. Mary M. Schroeder, Chief Circuit Judge, U.S. Court of Appeals for the Ninth Circuit, the Hon. Charles S. Vogel (Ret.), Former Administrative Presiding Justice of the California Court of Appeal, 2nd Appellate District and former President of the California State Bar, and Patrick M. Kelly, Esq., Regional Managing Partner of Wilson Elser (where Judge Wright was a litigator for more than 20 years) and former President of the Los Angeles County Bar Association.
Serving the Central District, Judge Wright hears cases from Los Angeles, Orange, Riverside, San Bernardino, Ventura, Santa Barbara, and San Luis Obispo counties. He continues Southwestern's legacy of distinguished public servants and is the fourth alumnus to serve on the United States District Court in recent years. The other Southwestern alumni who have worked in this capacity are Ronald S. Lew '71, Gordon Thompson, Jr. '56 (Southern District), and Robert S. Bardwil '79 (Eastern District).
A devoted and distinguished alumnus, Judge Wright always makes time for Southwestern, serving on the law school's Board of Trustees since 2002 and speaking at Black Law Student Association (BLSA) events. "I have a great fondness for the school," Judge Wright said. "I think it taught me well. All three of my law clerks and all but one of my externs are from Southwestern."
After several months on the federal bench - he officially began serving in April, 2007 - Judge Wright continues to impress his clerks, who regard him as a mentor. "I could just gush over this guy endlessly," said Haitham Kahwaji, a 2007 Southwestern graduate. "I'm absolutely amazed by him. He doesn't waste time, but he's very patient and kind. He commands respect, but he has an informal air about him, doesn't stand on formality like most other judges."
Josh Post, who graduated Southwestern in 2006, is also serving in a two-year clerkship for Judge Wright. "He's very quick, which not only comes from his years of experience in the legal field, but it's also something you can't learn, a unique common sense," Post said. "He has street smarts about him but almost in a legal sense."
Judge Wright began his legal career as a Deputy Attorney General in the Criminal Appeals Section of the California Department of Justice. During his three years in the office, he handled more than 200 appeals before the state's Court of Appeal and the Supreme Court. He went on to join the international law firm of Wilson, Elser, Moskowitz, Edelman & Dicker, specialists in all matters related to insurance, where he became a partner and was a civil litigator for more than 20 years.
"In 22 years with the firm I encountered attorneys of all different personality types, which I was later to learn would come in handy," Judge Wright said. "I learned to withhold judgment until I had heard all sides of the story."
During that time, he was also a volunteer attorney with the HIV AIDS Legal Services Alliance (HALSA), handling housing and employment discrimination cases as well as preparing wills for the terminally ill. In November 2005, Governor Arnold Schwarzenegger appointed Judge Wright to the Superior Court where he was assigned to the Substance Abuse Court.
Originally from Tuskegee, Alabama, Judge Wright earned his B.S. degree from California State University, Los Angeles in 1976 and his J.D. from Southwestern in 1980. Before attending college, Judge Wright served as a sergeant in the U.S. Marine Corps, a place he said best prepared him to take law school seriously because it was there that he was "indoctrinated in the concept that failure is not an option." He then spent 11 years as a deputy sheriff in Los Angeles where he worked while attending undergraduate and law schools.To learn more about Judge Wright, read his Q & A
with Southwestern.


text:
PINEVILLE, Mo. (AP) -- A suspect wanted in three states was captured in southwest Missouri after a chase that authorities allege included two car thefts, ramming a sheriff's car and robbing a store.
The 46-year-old man from Pineville, Mo., is wanted in South Carolina, Ohio and Louisiana for charges including burglary, assault and theft of weapons.
He is jailed in McDonald County awaiting charges after a wild chase that began Tuesday near Noel when he refused to pull over for a traffic stop on Missouri 59, The Joplin Globe reported (http://bit.ly/N7KIYb ).
Authorities say the car was found abandoned at a home south of the Shady Beach Campground, where a pickup truck was reported stolen. When the pickup was seen headed to Oklahoma, McDonald County Sheriff Mike Hall drove into that state and saw the truck at a convenience store on Highway 10. The suspect fled with Hall chasing, eventually ending up at a dead end on a gravel road. Authorities say the suspect turned around and rammed the sheriff's car, sending it off the road. Two deputies fired at the truck's wheels but it kept going.
A short time later, a report came in of a robbery at The Smoke Shop on Route O on the Missouri side of the state line. Authorities allege the man, armed with a handgun, demanded money, barricaded the store clerk in a bathroom and left with the clerk's car.
Missouri State Highway Patrol troopers then saw the car and chased it into Southwest City, where the suspect was arrested without resistance while he hid behind a house.
He is being held at the McDonald County Jail on a charge of tampering with a motor vehicle. The state patrol said charges of robbery, armed criminal action and unlawful possession of a firearm, and various traffic violations also were being sought.
Authorities said the man is wanted in South Carolina on charges of forgery, burglary and theft of weapons; in Ohio on a probation violation in drug and assault cases; and in Louisiana on charges of burglary and theft of weapons.
Information from: The Joplin (Mo.) Globe, http://www.joplinglobe.com


text:
Note: This item is more than three years old. Please take the publication date into consideration for any date references.
Print – Plain Text – Permalink
News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
Jan. 9, 2014
Texas State History Museum to Host Battleship TEXAS Exhibit
AUSTIN – The Texas Parks and Wildlife Department exhibit, "The Last of the Dreadnought Battleships," will open on Feb. 1 at the Bob Bullock Texas State History Museum and run through April 13. The exhibit pays homage to the Battleship TEXAS, which was commissioned 100 years ago.
The exhibit, which will highlight the history of the Battleship TEXAS in service to the United States Navy through World War II, will showcase 60 artifacts of the only surviving U.S. Navy vessel to have seen action in both world wars. Artifacts on view will include select pieces from the silver service presented to the battleship by the people of Texas, historical photographs and personal items from men who served aboard the TEXAS. A special listening station shares crewmember memories of service aboard the TEXAS during World War II.
The exhibit will be located in the Third Floor Rotunda Gallery of the Bob Bullock State History Museum, 1800 Congress Ave. Hours are 9 a.m. to 6 p.m. Monday through Saturday, and noon to 6 p.m. on Sunday. The museum will host special High Noon Talks on the Battleship TEXAS on the first Wednesday of February, March and April.
The mini-exhibit is a cooperative effort of the Bullock Museum and TPWD's Curatorial Services, Exhibit Shop and Battleship TEXAS State Historic Site.
In 1948, the decommissioned TEXAS became the first battleship memorial museum in the U.S. and today is anchored in the Houston Ship Channel in LaPorte. TPWD took over management of the historic ship in 1983.
In the early 20th century, fleets of armored attack warships guaranteed command of the seas. To keep up, the U.S. Navy replaced the 1892 Battleship TEXAS with a larger all-big-gun "super-dreadnought" version commissioned on March 12, 1914.
A little over 1000 men lived aboard TEXAS when commissioned; the number increased to over 1,800 during WWII. Texas's long history includes being the first U.S. Navy vessel to house a permanently assigned contingent of US Marines, the first US battleship to mount anti-aircraft guns, the first to control gunfire with directors and range-keepers (analog forerunners of today's computers), the first to launch an aircraft from a catapult, and one of the first to use radar equipment in the US Navy.
The U.S. Navy transferred TEXAS to the State of Texas in 1948, and for over 65 years, the ship has been open as a public memorial at the San Jacinto Battleground State Historic Site, 3523 Independence Parkway South, LaPorte, Texas. Because of the Battleship's age, key structural areas are in need of repair. TPWD is currently making critical vessel repairs to the ship's "skeleton" so that the ship remains strong enough to hold herself up.
If you would like to find out more about volunteer opportunities or how you can support the TEXAS, visit the ship at the TPWD's Battleship TEXAS State Historic Site or online at www.texasstateparks.gov.
A Battleship TEXAS fundraiser – a music festival headlined by Texas singer-songwriter Robert Earl Keen — will be held Saturday, March 15, at San Jacinto Battleground State Historic Site.
Publication — Permission is granted to publish, in whole or in part, any news releases on this page.
Print — A print-friendly version of the news release shows only the release with font sizes set to the browser default.
Plain Text — Plain text versions of TPWD news releases are provided for copying and pasting into editing software.
To copy text into an editing software:
- Click a Plain Text link to display the plain text page in your browser.
- Select all.
- Copy.
- Paste in a document in your editing program.
Permalink — This is a direct link to the news release, omitting the navigation context from the URI.
English/Spanish — News releases posted in both English and Spanish have one of these links.
If you have any suggestions for improving these pages, send an e-mail to firstname.lastname@example.com and mention Plain Text Pages.
(5.4.16 i)


text:
LEDBURY people will be able to comment on two quite distinct designs for a possible lift into the Market House, the town's iconic building.
There will be a comments' book underneath the Market House, during the consultation process; and displays concerning the Ledbury Places scheme.
The Ledbury Places steering group, under the chairmanship of Alex Clive, is set to meet today, Friday June 13, and give a collective nod to a consultation process that will install two rather different mock-up lifts into the listed building.
One mock-up will be a square lift, and the other will be tubular; but they will not be installed at the same time.
If all goes to plan, one will be in place one week, beginning the end of June, and the other will then be installed for a further week, once the first one has been removed.
Originally, Ledbury Places, which hopes to make the Market House a hub for tourism in the town centre, as Ledbury's jewel in the crown, wanted a mock-up lift in place for Ledbury's Community Day, on June 7.
But Mr Clive said that delays were caused by sorting out the insurance, and the group is also seeking the go-ahead for the mock-up from Herefordshire Council's conservation officer.
"The officer has been sent details of how the mock-up lifts will be fixed to what, after all, is a listed building," Mr Clive explained.
The Market House does not have disabled access, and anyone wishing to attend a town council meeting has to tackle a wooden Victorian staircase.
Because of the disabled access issues, wedding ceremonies ceased at the Market House a decade ago.
The building is raised on oak pillars, and the space beneath, where the lift will go, is currently used for the twice-weekly charter market and also community events, such a brass-band performances.
Ledbury Town Council's long-standing policy is to switch venues to the committee room in the town council offices, if disabled access is ever required for a meeting.
Mr Clive does not think that is really acceptable.
He said: "I think it seems to be the wrong attitude. What sort of a community are we, if have a disabled person shouting up from below?"
Without a lift and disabled access, Mr Clive sees the future use of the Market House as a community building as being limited; but not all agree with the idea of a lift.
Former town mayor, Dr Kay Swinburne, now MEP for Wales, wrote recently to town clerk Karen Mitchell and said she was "appalled" that the lift proposal had re-surfaced, a decade since the idea was rejected, after public protest.
Dr Swinburne believes the Market House as an ancient building could be exempt from disabled access laws, but the alteration of its fabric, by installing a lift, could leave the town council open to a legal challenge, because it is listed.
Dendrochronology testing indicates the Market House was erected using "green oak" in 1617.


text:
A Pilot, Open-Label, Phase II, Randomized Study to Determine the Effects of Viracept on the Outcome of Cutaneous and Mucosal KS in AIDS Patients With CD4 <= 500 Cells/mm3
This study has been completed.
Agouron Pharmaceuticals
Information provided by:
NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov Identifier:
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: May 1999
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
To determine the effect of Viracept in combination with modified antiretroviral therapy on the outcome of cutaneous and mucosal Kaposi's Sarcoma (KS).
|Sarcoma, Kaposi HIV Infections
|Drug: Nelfinavir mesylate
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:
|A Pilot, Open-Label, Phase II, Randomized Study to Determine the Effects of Viracept on the Outcome of Cutaneous and Mucosal KS in AIDS Patients With CD4 <= 500 Cells/mm3
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS Kaposi's Sarcoma Soft Tissue Sarcoma
Drug Information available for: Nelfinavir Nelfinavir MesylateU.S. FDA Resources
Further study details as provided by NIH AIDS Clinical Trials Information Service:
|Estimated Enrollment:
This is an open-label, randomized, pilot, Phase II study of the safety and efficacy of Viracept in combination with modified antiretroviral therapy as treatment in patients with cutaneous and mucosal KS. Patients will be randomized to modify (add or switch or initiate) their current antiretroviral therapy and will add Viracept or remain on their current background antiretroviral therapy for a 2 month period. Initially 20 patients will be randomized in a 2:1 ratio (i.e., 14 Viracept, 6 control) for a 2 month period. Response to therapy will be evaluated at the end of the 2 month control phase. At this point, patients who were initially assigned to the control arm will continue on open label Viracept for an additional 10 month period.
|Ages Eligible for Study:
|13 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Patients must have:
- HIV-positivity.
- Diagnosed KS proven by biopsy.
- Patients must not opt for immediate topical, systemic or radiation treatment.
- At least 4 cutaneous lesions not treated within the previous 4 weeks.
- Life expectancy > 6 months.
- Signed, informed consent from parent or legal guardian for those patients < 18 years of age.
Exclusion Criteria
Co-existing Condition:
Patients with the following conditions and symptoms are excluded:
- Neoplastic disease (excluding KS) requiring systemic cytotoxic or radiation therapy or who have had these therapies within 1 month of baseline and have not completely recovered from the effects of these therapies.
- Unstable or severe intercurrent medical conditions, including but not limited to, significant symptomatic visceral KS.
- Clinically significant malabsorption syndrome.
- Renal insufficiency.
Patients with any of the following prior conditions are excluded:
Significant Fever (> 101 degrees F (38 degrees C) for >= 7 days) and/or diarrhea (> 6 loose stools/day for >= 7 days) within one month of baseline.
1. Immediate topical or systemic treatment for KS lesions.
- Use of Retinoid class drugs, either topically or systemically, or beta-carotene compounds or Vitamin A doses of more than 15,000 IU (5,000 mcg) per day concurrently.
Immediate radiation treatment.
1. Treatment of KS lesions with intra-lesional chemotherapy within 4 weeks of entry.
- History of > 2 weeks of prior therapy with Indinavir or Ritonavir.
- Use of Retinoid class drugs, either topically or systemically, or beta-carotene compounds or Vitamin A doses of more than 15,000 IU (5,000 mcg) per day within 4 weeks of entry.
Treatment of KS lesions with radiation within 4 weeks of entry. Active substance abusers; urine drug tests may be performed if drug abuse is suspected.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002185
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002185
|United States, California
|LAC and USC Med Ctr / School of Medicine
|Los Angeles, California, United States, 90033
|Univ of California / UCI Med Ctr
|Orange, California, United States, 92868
|UCSD Treatment Ctr
|San Diego, California, United States, 92103
|Santa Clara Valley Med Ctr
|San Jose, California, United States, 951282699
|Harbor - UCLA Med Ctr - Box 449
|Torrance, California, United States, 90509
Sponsors and Collaborators
Agouron Pharmaceuticals
More Information
Keywords provided by NIH AIDS Clinical Trials Information Service:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00002185 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 2, 1999
|Last Updated:
|June 23, 2005
Keywords provided by NIH AIDS Clinical Trials Information Service:
Skin Neoplasms
AIDS-Related Opportunistic Infections
Sarcoma, Kaposi
Drug Therapy, Combination
HIV Protease Inhibitors
Mucous Membrane
Anti-HIV Agents
Additional relevant MeSH terms:
HIV Infections
Sarcoma, Kaposi
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Herpesviridae Infections
DNA Virus Infections
Neoplasms, Vascular Tissue
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
The two nicest pieces from the Levi's x Porter collaboration this season have been released this week – a shoulder bag and a messenger bag, both coming in a mix of canvas and leather. Both pieces have lots of nice details, while keeping an overall clean and classic look. The bags are now available from e-Levi.
More images of the new Levi's Porter Bags follow after the jump.


text:
A MAN died of heart failure just three days after medics at Basildon Hospital stopped his angina pills despite protests from his family.
Relatives of Alan Hayes, 72, now want his death investigated as part of the probe into the hospital, which is among five hospitals with the highest death rates in the country.
Mr Hayes, 72, died three days after staff stopped him taking beta blockers and statins which had controlled a long-term angina problem.
The Hayes family said they were even reassured in a morning phone call to the hospital that Alan was "fine" despite him already having suffered the heart attack.
Just hours later he was dead.
His son, David Hayes, 43, from Wilson Close, Stanford-le-Hope, said: "I welcome any outside inquiry that will get to the truth of how care like this has been allowed.
We thought about complaining at the time, but were still grieving and thought what good would it do.
Now that we know we are not alone we want this properly investigated in the inquiry."
The family say the drugs had kept Alan's heart problem under control and he had never had a heart attack before the one in hospital which killed him.
Alan was admitted on Friday, March 9 last year due to concerns about weight loss believed to have been caused by under eating due to the painful side effects of rheumatoid arthritis medication.
David said: "He was referred by the doctor in Orsett to Basildon and put on a drip, but they stopped all his medication.
Because he had angina we said he should not just come off the beta blockers and statins like that, but they were not concerned at all and said they needed to assess him for any other illnesses, so we just trusted them."
The family called each morning to check on him and visited during the day.
Daughter Michelle Fogg, 37, said: "On Monday morning we called and were told he was fine.
When we went in to visit at 12pm he had a mask on his face and it was then they told us he had a heart attack in the night.
We believe that this only happened because they stopped his angina pills." She said a patient in the next bed said Alan had complained through the night of chest pains, but nothing was done.
Alan was then moved to the Elizabeth Fry ward where he was left for more than three hours without a drip because they were awaiting his medical notes.
Mr Hayes added: "A doctor eventually came and tried to tell us right in front of dad that he was dying.
We asked him to tell us out of his earshot as it would panic him, but by the time we got back to the bed he was dead." A hospital spokeswoman said: "The hospital strives to provide all of its patients with high quality safe care.
"We would encourage the family of Mr Hayes to contact the trust so we can investigate their concerns in full and establish whether there were any issues with their father's treatment."


text:
NEWPORT Gwent Dragons' potential hooker crisis looks to have been averted with the region hopeful both Steve Jones and Hugh Gustafson will be fit for Saturday's Munster showdown.
The pair picked up injuries in last weekend's bitterly disappointing 16-5 big derby defeat to fierce rivals Cardiff Blues at Rodney Parade.
Jones left the field with a calf injury after 52 minutes to be replaced by converted hooker Gustafson, the former loosehead prop then going on to hurt his ankle.
Their injuries had raised the spectre of the Dragons being down to just one fit hooker in Sam Parry. But the initial prognosis is understood to be good and the duo were yesterday in contention for the weekend's away clash at Limerick's famous Thomond Park.
A further assessment of their fitness is being carried out today.
Another boost for the Dragons is that the forecast for centre Andy Tuilagi is similar after he hurt his calf in the loss to the Blues four days ago.
The Samoa international didn't return to the field after the interval but had an excellent first 40 minutes, causing panic in the visitors' defence with his direct running.
If he is passed fit, his experience will be invaluable in Saturday night's cauldron.
Meanwhile, the news about the other four Dragons on the casualty list is not quite so good.
South Africa international wing Tonderai Chavhanga is still not match fit but was back in contract training on Monday after he hurt his knee in the 31-12 defeat to the Ospreys in Swansea back in May.
Last season's Argus player of the year Robert Sidoli will also not be in contention for Munster, the 33-year-old 2005 Grand Slam-winning second row is still recovering from a calf injury.
And ongoing injuries to scrum halves Wayne Evans (back) and Joe Bedford (shoulder) mean that promising young No 9 Jonathan Evans is set for more vital big match experience against the 2006 and 2008 Heineken Cup champions.
After Saturday's defeat and the previous weekend's 45-25 setback against Leinster in Dublin, to go with their 37-6 opening day victory over Zebre, the Dragons have a tough task ahead of them this weekend.
Munster have started the season well with a 23-18 away win at Edinburgh and a 19-6 home victory over Benetton Treviso before being pipped 20-19 against Ulster at Ravenhill on Friday night to sit fourth in the PRO12.
The Dragons have only won once away at Munster in their history, that was a 16-6 victory at Limerick under coach Mike Ruddock during their inaugural season of 2004.
The only survivor from that victory still playing with the Dragons is 35-year-old hooker Jones who played in a team that included South Africa stars Percy Montgomery and Bobby Skinstad.


text:
Topic: Bile Duct Cancer Walk, Montain View, California
On Saturday I met up with the folks at the annual Bile Duct Cancer Walk, in Mountain, View, California.
Danny Cmiel, then a 4th grader initiated the idea of a bile duct cancer walk for a school project. It has grown tremendously with upcoming consecutive walks in numerous US locations. Well done, Denny, you are an inspiration. Denny graciously allowed me to take his picture which I hope to be able to post. (Of course, I need Rick