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For a brief time last year, I found myself in the bridal industry niche for women planning their second weddings, a group Miss Manners calls "older" brides. It's unclear when one falls into that "older" bride group, but on its last cover, the now-defunct Bride Again magazine featured a woman who couldn't have been more than 35.
I've been around longer than that, but until I headed for the altar, I just thought I was "wiser."
Because the divorce rate is now approximately 50 percent, according to the National Center for Health Statistics, one would think that encore brides would have a real presence. However, most of them must be getting married quietly or in a chapel in Reno.
When I first tied the knot many moons ago, getting married was highly unfashionable. We did it anyway, in a large outdoor party at someone's house where guests danced the night away to music from a friend's rock 'n' roll band. My mother was not amused. She had probably hoped that I would "act my age."
Times have changed since the 1970s, so I decided to consult Miss Manners, aka Judith Martin, and other bridal experts. Most brides think the second wedding is the only one that counts, according to Martin, so they often decide to do it right, with an "event."
From Miss Manners, I learned that the older bride wears a suit and hat and holds an appropriately subdued afternoon ceremony with punch and cake.
Like many baby boomers, however, I was not used to acting my age to that extent. I was used to celebrating milestones in a big way. Well, as big as limited finances would allow, considering we were nearing retirement age with the ensuing prospect of fixed incomes.
Several obstacles soon presented themselves. There was the color of my gown – and yes, I was determined to wear one, not a frothy, frilly number, but something that alluded to my experience, in a veiled way.
After my future mother-in-law congratulated me on landing the grand prize – her smart and talented son – she surprised me by saying, "Of course, you can't wear white." There aren't too many black bridal gowns on the market, and actually, I had rather envisioned myself in white.
This idea that you cannot wear white is apparently commonplace but nonetheless misguided. Martin explains on page 409 of her "Miss Manners' Guide to Excruciatingly Correct Behavior" (W.W. Norton & Company, 2005) that the white-equals-innocence concept started with Queen Victoria.
However, Martin takes offense, stating pithily that the idea that white packaging advertises untouched goods always strikes her as "vulgar as it is unlikely." Wish I had thought of that.
Because the bride makes a grand entrance, I did need to consider how to package myself. I called Priscilla of Boston on Santana Row and asked Summer about dresses for older brides.
There's no separate section, but the store stocks dresses that are "a little more conservative, that cover up more, if that's what you mean." She noted that these encore bride dresses were "plainer, for second weddings."
It's true that encore brides have different couture needs. I spend time at the gym, but not that much time, so camouflage ranks high on my list of sartorial requirements. Baring my arms, shoulders or even my neck for professional photographs makes me blanch, not blush. So I thought we could drop by Priscilla's to look at the dresses.
Next, we had to book a venue to nail down a date. We decided on marrying in a winery, a suitably Northern California idea that would underscore our sophistication, or so we thought.
I booked several appointments with winery social directors to get the grand tour. This is when I began to feel, well, foolish, not unlike the older man who chases after women half his age.
The appointments before and after mine seemed to be taken by gaggles of giggling teenagers, though they couldn't have been that young. They had to have reached the age of majority.
A quizzical look would appear in the über-polished wedding event director's eyes.
"Is this for you?" he or she would say in a tactful tone.
If you look at the magazines lined up at the local Borders bookstore, you will see dozens of bridal magazines, most featuring young blond women in strapless sweetheart gowns. None of them appears to have weathered a few years.
I asked the public relations director at a recent Santa Clara bridal fair if there were any magazines or booths for the mature bride, and she said, no, though there was one for grooms.
They just have to wear tuxedos, so why do they need their own magazines?


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Dear Friends
have any of you made a traditional Swedish princess cake? Rose has supplied recipes for all of the ingredients for it: genoise, pastry cream, soaking syrup. I'm a little intimidated by the Marzipan layer over a whipped cream dome. On the blogs out there, some bakers have noted that the marzipan just collapses into the whipped cream.
What have been your experiences with this type of cake?

subset: commoncrawl


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A police community support officer has been injured while helping police officers detain a suspected shoplifter on The Strand in Torquay.
At 11.45am on Monday 26 November, during an arrest in connection with Operation Action, the suspect also received an injury to his head. Both were taken to Torbay Hospital by ambulance.
The arrested man, aged 30, was from Stockton. Perfume was recovered at scene.
Operation Action is a high profile anti-shoplifting initiative, run by local police in the run up to Christmas.


text: OverviewBack to top Good Earth Teas - Matcha Maker Green Tea Orange - 18 Tea Bags Formerly Super Green Tea Matcha Sencha & Orange Item# :75646UPC# :027018099246 Brand:Good Earth Teas Size/Form:18 Tea Bags Ship Weight:0.20 Servings:18 Dosage:1 Tea Bag(s) Flavor:Orange Good Earth Teas - Matcha Maker Green Tea Orange - 18 Tea Bags Good Earth Teas Matcha Maker Green Tea Orange is smooth and clean. Good Earth Teas Matcha Maker Green Tea Orange has a juicy orange flavor. It's hard to improve on green tea, but Good Earth has tried. Good Earth blends Premium green tea, antioxidant rich matcha and sencha teas from Japan to give you 70% more antioxidants than your standard green tea. Good Earth Super Green Tea has 162mg avg. antioxidants per serving vs. Good Earth's standard green tea with 108mg avg. antioxidants per serving. Accented with the hints of juicy Californian oranges the result is a green tea that Good Earth thinks is, well...super. Enjoy hot or iced. A Natural Source of Antioxidants Rich All Natural Flavor Individually Wrapped For Freshness Good Earth teas are simply about taste. Good Earth's aim was to create a range of organic teas that didn't compromise on flavor. Good Earth selected only premium natural ingredients, grown without the use of artificial pesticides or herbicides. Good Earth thinks the result is a range of richer, more flavorful teas that are good for you and good for the earth. Good For The EarthGood Earth is reducing the environmental impact of their products by removing the plastic over wrap from some of their tea boxes and the boxes are now sealed with 2 small labels. Good Earth uses less materials and the packs are easier to open - what's not to like? This doesn't affect the freshness and safety of Good Earth products as all Good Earth tea bags are individually enveloped for freshness. All Good Earth cartons are produced from 100% recycled board and are printed with soy based inks. Even the tea tags are recycled. Finally, Good Earth is committed to protecting the environment by continuing their support for American Forests, helping to plant another 20,000 trees this year to fight global warming.Good Earth HistoryGood Earth's headquarter facility has been in Santa Cruz, California since it was founded in 1972. One of the first American herbal companies during the early 1970's and responsible for introducing Ginseng Tea to the US health and specialty markets. In the late 1970's it began to develop the trademark teas for the Good Earth Restaurants and launched Good Earth Teas in tea bag form to the California grocery market in 1988. From the Santa Cruz headquarters, Good Earth's staff manages all of the procurement, inventory, blending, packaging, sales and marketing of their signature tea products. Good Earth is one of the leading specialty tea brands in the United States today and was acquired by Tetley US Holdings Limited in October 2005. Tea HistoryTea is the second most consumed beverage in the world after water. Oriental lore tells us that a distinguished Chinese philosopher first smelled this wondrous aroma when tea leaves fell from the sky into his pot of boiling water. Thus was born the legacy of tea that has endured for centuries. From China to England, from India to America, tea has acquired a vast multitude of followers, leaving its mark on every civilization. Each day, over one and a half billion cups of tea are consumed on the planet. Perhaps no other beverage has been the object of such sanctification and ceremony: in China tea was idealized by poets and codified by tea masters; all the beauty of the Japanese way of life is embodied in its tea ceremony. In Britain "tea time" has dominated daily schedules for centuries. In the New World, the Boston Tea Party sparked off a series of events that changed the course of history. About Teamade entirely of herbs, flowers or bark are more accurately called infusions or tisanes. How tea leaves are processed determines how they're classified. Black tea is made from leaves that have been "fermented", or oxidized, over heat. Oolong is only partly fermented. Green tea, which is steamed, is not fermented. Researchers keep amassing evidence that tea - especially green tea, the kind that contains the most antioxidants - have many health benefits. Premium quality specialty teas are increasing in popularity. Indications are that specialty teas will grow even more rapidly over the next five to ten years. Good Earth's Partnership with American ForestFounded in 1875 by a small group of environmentally conscious citizens, American Forests is the nation's foremost nonprofit conservation organization. From these historic roots, this remarkable organization has carried into the 21st century with the Global ReLeaf 2 campaign, an extension of their 1988 initiative which has been responsible for planting more than 25 million trees in over 500 projects throughout the U.S. and internationally. The re-launch, in response to the ever-growing problems brought on by rising global temperatures, carries the ambitious goal to see 100 million trees planted by the year 2020, a goal that can only be attained through the support of communities, businesses, and individuals. By helping American Forests to restore and protect the life-giving ecosystems of forests, we can help prevent the loss of more trees and improve the quality of life for generations to come. Good Earth's Contribution to the CauseDonations from Good Earth will plant over 40,000 trees through the American Forest's projects. The American Forests logo/link will be placed on 7M Good Earth boxes over a period of 1 year. Planting these trees will remove 6,667 tons of CO2 from the atmosphere over a 50 year span - the equivalent of removing 900 automobiles from our highways! Good Earth is Proud to Support the Work of Original T-Bag Designs"The donations that Original T-Bag Designs receives at the Good Earth Tea Bag Drive will provide a boost to the South African artists," said Jodee Hetzer, U.S. representative for Original T-Bag Designs. "The artists painstakingly hand-paint every tea bag so each one becomes a real work of art. The work enables them to provide better lives for their families and beauty for the world – all from recycled tea bags." "Good Earth is excited to be supporting the work of Original T-Bag Designs," said Roberto Avila, Senior Brand Manager, Good Earth. "We hope that those who enjoy our great-tasting variety of richer tasting teas will be inspired to help the artists of Original T-Bag Designs by donating their brewed tea bags at the events." About Original T-Bag DesignsThe story of Original T-Bag Designs began in 1996 when Jill Heyes moved to South Africa from England. Seeing the poverty in the local informal settlement of Imazamo Yethu, Jill wanted to help. She began teaching some local women crafts. Although they unsuccessfully attempted to sell paper mache and potato printing products, they did not give up. In 2000, Original T-Bag Designs was formed when the artists were able to create artwork from used, brewed tea bags. The original group of artists have become skilled and talented at their craft. T-Bags Designs now employs 15 permanent staff and a number of additional part-time employees. In addition, 10 people with disabilities from within the community are employed to assist with sanding products. The Original T-Bag Designs workshop is a tourist destination, and their products are available for purchase at the workshop, at Cape Town's Waterfront Market, i


text: Kids' Star Wars™ doodles book Item E7364 Color: STAR WARS BOOK Size: ONE SIZE All sizes are US sizes. ONE SIZE Size Charts Quantity: 1 2 3 4 5 6 7 8 9 Prices do not include taxes. Add to Bag Wishlist Add to Bag Add To Wishlist share: size & fit Product Details This cool, kid-friendly coloring book that features all their favorite Star Wars characters is bleep, bloop, blop, bleep, boop (translation: out of this world). Import. Item E7364.


text:
Hellickson endures rough second rehab start
HOUSTON -- Rays starter Jeremy Hellickson threw his second rehab start on Thrursday for Triple-A Durham, as he continues to work his way back after offseason arthroscopic elbow surgery.
Hellickson's start didn't go exactly as planned, however, as he gave up four runs and six hits in 2 1/3 innings. He threw 35 strikes and 20 balls as the Bulls lost 4-0. He was slated to throw 60 pitches and four innings.
"I guess he got beat up a little bit," manager Joe Maddon said. "Otherwise, the results weren't there but that doesn't really matter right now."
Hellickson threw one previous rehab start at Class A Advanced Charlotte, in which he threw three scoreless innings.
He was 12-10 with a 5.17 ERA for the Rays in 2013.
Mike Vernon is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


text:
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Brewer at the Legislature: Mob rule
North Platte Seventh-day Adventist Church to discuss liberty, life of Constantine the Great
More opinion
Robertson and Delsing re-elected chair, vice chair of NWB
Goat Expo set first October weekend
More Ag News
Nebraska lawmakers advanced a bill Tuesday aimed at improving the quality of child care centers and changing the eligibility of families receiving assistance to use those centers.
It would create quality criteria for child care centers in Nebraska, would make information on the quality of certain centers available for parents, and provide accountability for the state dollars spent on those centers.
Beginning July 2014, all centers that received more than $500,000 in state aid in the 2011-2012 fiscal year would participate in a rating and improvement system.
By 2015, centers that received more than $250,000 in state assistance will be required to participate.
I want a system where every parent, no matter of their income, can know what quality is, see how their center stacks up, and to know that their child has good, quality care, Campbell said.
Some senators expressed concern about how the bill would affect smaller counties that have fewer options for child care centers. If a center did not fulfill every standard of quality, parents may have nowhere else to send their children.
Campbell said that, because only centers that receive a certain amount of money are required to participate in the quality system, smaller counties will not have to worry as much about participation but could voluntarily participate.
However, she added that some centers would be affected all across the state.
Sen. Danielle Conrad of Lincoln proposed an amendment (AM 1173) that would change which families are eligible for federal child care assistance program, and the amendment was adopted on a 26-0 vote.
Under current practice, families who are at 120 percent of the federal poverty level, such as families of three with an income of about $23,000, are eligible for assistance.
Under the amendment, families who are at 125 percent of the federal poverty level would be eligible for assistance in the 2013-2014 fiscal year.
The eligibility would change to families who are at 130 percent of the federal poverty level in the 2014-2015 fiscal year.
I think its critical that we keep access and quality, when it comes to early childhood education and child care, intertwined as it should be, Conrad said. My amendment would help to raise our standard.
She added that her amendment rewards Nebraskans for working by giving their children a safe place to go while the parents are at work.
Conrad said that in 2002, families at 185 percent of the poverty level were eligible, and this amendment was an attempt to get closer to that original allowance.
In 2002, the Legislature reduced the eligibility level for assistance to 120 percent of the poverty level for budget reasons.
Sen. Dave Bloomfield of Hoskins questioned, however, if the Legislature had been too generous in 2002 with that level of eligibility, which could explain why the eligibility experienced such a drastic change with the budgetary cuts that year.
Many senators stressed the need for quality childhood care because it is a crucial time for development.
When children do not receive a quality early childhood education, they can be one or two years behind their peers, Campbell said. She added that the achievement gaps seen in college are the same achievement gaps seen from students entering kindergarten.
Sen. John Harms of Scottsbluff added that teachers are assessed based on student performance when those students are coming to school already behind what is expected.
Sen. Heath Mello of Omaha said that, with the change in the school state aid funding, approximately $8 million would be made available, which is the projected cost of the change in eligibility and quality of child care.
Sen. Bill Kintner of Papillion said, however, that the extra money belongs to the taxpayers.
Give them back their money, he said.
Flatrock Publishing, Inc.
1300 E 4th St., Suite F
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|Jeffrey Crowley
|Written by Jennifer Nodwell
|Monday, 23 August 2010 04:21
One of Omar Travis Osborne's direct ancestors, his great-great-great-great-grandfather, is Jeffrey Crowley. Jeffrey Crowley was born 29 March 1702, in Kinwarton, Warwickshire, England. No one knows for certain (yet) who his father was. Some researchers believe he is the illegitimate son of Jeffrey Hopkins and a hired girl, Agnes Crowley. Others believe he is the son of Samuel Crowley, who was the estranged son of Ambrose Crowley II of Stourbridge, England. This Samuel ran away and went to sea, and his half-brother is the famous Sir Ambrose Crowley III. Sir Ambrose mentions his half brother having had a bad time at sea which distressed their father. Neither possibility of parentage can (as of yet) be firmly established.
Either way, our Jeffrey Crowley first appears in Orange County, Virginia when he sues James Stodsgill for land that he sold in 1730 or 1731. He was married to Effie at this time and has probably had his first child. Jeffrey and Effie are mentioned in several court cases in Orange County, seemingly stemming from this first case over the land deal. Not much is known of Effie, except that she died some time between 1755 and 1757, at which time Jeffrey had remarried to a Mrs. Martha Edwards, the widow of Thomas Edwards. Jeffrey Crowley died in Halifax County, Virginia in 1761.
Jeffrey and Effie had at least four children: John, Benjamin, Mary, and Samuel. Benjamin was born around 1739 in Orange County, Virginia and married Sarah Strong. In 1755 in Bedford County, Benjamin's asignee, James Tilley, received a wolf's head bounty for 50 pounds of tobacco. Later, in 1758, he was paid for 23 days of service in the Halifax County Militia. Benjamin and his family moved through Pittsylvania County, Virginia, and finally settled in Oglethorpe County, Georgia, where he died around 1817.
The name of Jeffrey's first wife is on a deed dated September 1755, in Bedford County, in which Effie and Jeffrey sold 200 acres in Bedford to William Callaway. The Crowley-Callaway relationship extended back to 1735 in Orange County. From Jeffrey's will and inventory, we learn he was a gentleman who wore stockings and had a great coat and this coat was valued at more than his bull. He was a breeder of fine horses used for racing. He said one mare was "running at Thomas Callaway's and another was running at Leatherwood [Leatherwood Creek in Henry County]." It is also believed that Jeffrey owned a peach orchard on the James River back in 1738 and most likely owned a distillery to make peach brandy. His associate, Col. William Callaway owned a store and sold brandy.
In the codicil to his will, Jeffrey said that he wished the remainder of his property to be divided among his four children. He named only two, being Benjamin and Samuel Crowley. But over the years, other family historians have determined the identity of the two who were not named. One was Mary who married Randolph Gibson named in Jeffrey's will, and the other is assumed to be the eldest son, John Crowley. By the laws of progenitor, often the first son was not named in wills, as it was understood he would inherit the family homestead. The will is not conclusive evidence that Jeffrey had only four children.
The following are excerpts from "The Genealogy of the Crowley's," by Paul R. Crowley, and up-dated by Sue and Harold Crowley.
Jeffry Crowley, his wife Martha and at least one child, Benjamin, came to Virginia in the Great North Ireland Protestant Migration, beginning in 1728. It is thought they arrived about 1734 or 35, as his name appears on records in Orange Co in 1735.
Jeffry was of Protestant Faith, a Hardshell Baptist. The rest of Ireland was Catholic, and were not welcomed in America until about 20 years later, when the great Catholic Migration for America began.
It is not known whether Jeffry was born in England or in Ireland. His father, John, was born in Herts Co., England. John's 8 or 9 boys seemed to have come to Va. from Ireland.
History of the migration states that the people took passage so fast there were almost no records kept of those leaving for America. There were no family or Port of Embarkation records kept, and in America, there were no Port of Entry records kept. So, it is not known who or how many came at that time.
Ben and Sam owned land on Little Sandy River, near that of their father on Little Otter River. Their lands were in Pittsylvania Co. Ben occupied his until he sold out in 1783 to go to Georgia.
Old Sam and his wife Elizabeth sold out in 1773, probably expecting Sam to be called into the Virginia Rangers. He was called up for service, as the Indians, encouraged by the British, were on the war path. General Andrew Lewis led his Virginia Rangers against the Shawnees under their brave leader, Chief Cornstalk, in the Battle of Point Pleasant on the Ohio River in Western Va. and defeated them in a hard fought battle. This was October 10, 1774. Many were killed on both sides, including Old Sam and the General's brother, Charles. The next day a Treaty of Peace was signed.
Will of Jeffrey Crowley
1761 Oct 17 - HALIFAX CO, Va - Will Bk O:137 Will of JEFFREY CROWLEY written: CODICIL: 17 Oct 1761; Proved: 18 Feb 1762"
In the name of God, Amen... I, JEFFREY CROWLEY of the Parish of Antrim in the County of Halifax, planter BEING VERY SICK & WEAK IN BODY, but of perfect mind & memory, thanks be given unto God therefore calling unto mind the mortality of my body & knowing that it is appointed for all men to die, do make & ordain this my last will & Testament that is to say, principally & first of all I give & commend my soul unto the hands of God that gave it & for my body I commend it to the earth to be buried in a Christian like & decent manner at the discretion of my Executors nothing doubting but at the general resurrection I shall receive the same again by the mighty power of God and as touching such worldly estate wherewith it hath pleased God to bless me in this life I give devise & dispose of the same in the following manner & form: #1 - It is my will & I do order that all my just debts & funeral charges be paid & satisfied. #2 - I give unto my dearly beloved wife, MARTHA [2nd], one NEGRO FELLOW NAMED PETER with all my stock of cattle & hogs & household goods & my work horse & a YOUNG BAY MARE & moveables during her life. #3 - I do give to my well beloved CHILDREN after her decease, all my estate to be divided among them & their heirs & assigns forever. #4 - I give to my well beloved SON, BENJAMIN CROWLEY, ONE GRAY MARE RUNNING AT THOMAS CALLAWAYS & to my SON, SAMUEL CROWLEY ONE BAY MARE NOW IN HIS POSSESSION & A COLT that came of the gray mare 2 years old next spring & to RANDOLPH GIBSON, a BAY MARE that I had of Joseph Austin & HORSE COLT THAT RUNS AT LEATHERWOOD [Creek in now Henry Co] & some debts that is due to me in BEDFORD COUNTY & a HORSE THAT RAN AWAY INTO AUGUSTA [Co, Va] if he can get him & a bond of 46 shillings on William Walker & same in COLO. WILLIAM CALLAWAYS HANDS & same in JAMES TILLEYS HANDS. And to BENJAMIN and SAMUEL CROWLEY 10 lbs, 11 shillings & 6 pence that DANIEL DUNN owed me & to John Heale a BAY YEARLING MARE COLT that I had of him. And I do hereby utterly disallow, revoke & disannul all & every other former testament wills legacies & executors by me in any way before this time. Ratifying & confirming this & no other to be my last will & testament in witness whereof I have hereunto set my hand & seal the day & year above written.. /s/ JEFFREY (o) CROWLEY [his mark, a circle containing a cross]. Signed, sealed, published, pronounced & declared by said Jeffrey Crowley as his last will & Testament. Witnessed by GEORGE BRITTAIN, JOHN (X)
JONES, JOHN HARRIS Codicil written same day (p.138): I Jeffrey Crowley of Antrim Parish, Virginia on this 17 of Oct make this my codicil: It is my desire that after my wife's decease that the NEGRO FELLOW PETER be given between my TWO SONS, BENJAMIN CROWLEY & SAMUEL CROWLEY and the other part to be DIVIDED BETWEEN MY FOUR (4) CHILDREN EQUALLY & if either of them can pay the other his part of the NEGRO [Peter] to keep him & if not to sell him to the highest bidder & divide the money equally & a red cow with her horns sawed off to RANDOLPH GIBSON & a heifer that came of a cow named Chanak to my son BENJAMIN & another of the same age to SAMUEL CROWLEY. /s/ JEFFREY (JC) CROWLEY.
1762 Feb 18 - Halifax Co, VaAt a Court held for Halifax Co, the last will was proved by the witnesses & the testator having appointed no Executor of his last will, certificate was granted to MARTHA HIS WIDOW who obtained letters of Admr. and THOMAS EDWARDS & WILLIAM WRIGHT became her securities.
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|Last Updated on Tuesday, 24 August 2010 22:19


text:
Investigation of the Impact of Noninvasive Prenatal Testing for Fetal Aneuploidy on Utilization of Prenatal Diagnostic Procedures and Pregnant Women's Views
This study has been completed.
Verinata Health, Inc.
Information provided by (Responsible Party):
Verinata Health, Inc.
ClinicalTrials.gov Identifier:
First received: October 15, 2012
Last updated: September 24, 2014
Last verified: September 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is a prospective, single-institution observational study to be conducted at 4 clinics within the Southern California Permanente Medical Group. Pregnant women who present for prenatal genetic counseling at the designated clinics and who meet study eligibility criteria will be offered the option of the verifi® prenatal test by a trained, licensed and certified genetic counselor (GC) . Women who elect the verifi® prenatal test will have a blood sample drawn by peripheral venipuncture that will be sent to the Verinata Health CAP-accredited clinical laboratory (Redwood City, CA). Results will be reported to the ordering health care provider by the laboratory within 8-10 business days and will be shared with the subject by their provider. Subject care and decision-making following NIPT result will be clinically managed by the provider with his/her subject and is not dictated by the study protocol. All eligible women who provide informed consent, whether they elect or decline NIPT will be asked to complete a short questionnaire on their views of prenatal testing. The uptake of invasive prenatal procedures (CVS and/or amniocentesis) by the total prospective cohort will be collected through review of electronic medical records (EMR). A historical cohort with matched demographic and pre-test indications to the prospective cohort will be identified from the EMR for comparison in the primary analysis.
|High Risk Pregnancy
|Study Type:
|Study Design:
|Observational Model: Case Control
Time Perspective: Prospective
Further study details as provided by Verinata Health, Inc.:
Primary Outcome Measures:
- Invasive prenatal procedures rate measure by the occurance of chorionic villus sampling (CVS) and/or amniocentesis [ Time Frame: Enrolled women will be evaluated on or before Gestational Age: Wk 28 ]The primary objective of this study is to compare the rate of uptake of invasive prenatal procedures (chorionic villus sampling (CVS) or amniocentesis) between a prospectively enrolled cohort of pregnant women at high-risk for fetal aneuploidy who are offered noninvasive prenatal testing (NIPT; verifi® prenatal test) and a historical cohort matched for demographics and pre-test risk indications. The prospective group will include both those who accept NIPT and those who decline NIPT, but are willing to consent and complete a brief questionnaire.
Secondary Outcome Measures:
- Preferences of pregnant women on prenatal testing by completion of preference questionnaire. [ Time Frame: Evaluated at time of enrollment ]The secondary objective is to collect views/preferences of pregnant women on prenatal testing for fetal chromosomal abnormalities and compare results of eligible women who accept versus those who decline NIPT during the enrollment period.
|Study Start Date:
|November 2012
|Study Completion Date:
|October 2013
|Primary Completion Date:
|September 2013 (Final data collection date for primary outcome measure)
|Enrolled subjects
|Historic control
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Study Population
The study population is comprised of pregnant women at least 18 years of age, who meet the inclusion criteria but none of the exclusion criteria described below. Women who present for prenatal genetic counseling at one of the designated study clinics will be recruited.
Inclusion Criteria
- Age 18 years or older at enrollment
- Clinically confirmed singleton pregnancy
- Gestational age between 10 weeks, 0 days and 20 weeks, 0 days
- Referred for prenatal genetic counseling due to increased risk for fetal aneuploidy (advanced maternal age (AMA ≥ 35 years at delivery, high-risk prenatal screen result, abnormal fetal ultrasound finding consistent with fetal aneuploidy, and/or history of prior affected pregnancy for fetal aneuploidy)
- Pregnancy records accessible and available for data collection (e.g., results from screening, ultrasound examinations, invasive prenatal procedures if performed, and infant hospital discharge exam)
- Able to provide consent for participation using language-appropriate forms
Exclusion Criteria
- Invasive prenatal procedure (amniocentesis or CVS) already performed
- History of demised or vanished co-twin (spontaneous or following in vitro fertilization)
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01708746
Please refer to this study by its ClinicalTrials.gov identifier: NCT01708746
|United States, California
|Southern California Kaiser Permanente Medical Group
|Baldwin Park, California, United States, 91706
|Southern California Kaiser Permanente Medical Group
|Los Angeles, California, United States, 90027
|Southern California Kaiser Permanente Medical Group
|Panorama City, California, United States, 94102
|Southern California Kaiser Permanente Medical Center
|Woodland Hills, California, United States, 91367
Sponsors and Collaborators
Verinata Health, Inc.
|Principal Investigator:
|George E Tiller, MD, PhD
|Kaiser Permanente, Dept Genetics
More Information
ClinicalTrials.gov processed this record on September 21, 2017
Bianchi DW, Platt LD, Goldberg JD, Abuhamad AZ, Sehnert AJ, Rava RP; MatErnal BLood IS Source to Accurately diagnose fetal aneuploidy (MELISSA) Study Group. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol. 2012 May;119(5):890-901. doi: 10.1097/AOG.0b013e31824fb482. Erratum in: Obstet Gynecol. 2012 Oct;120(4):957.
|Responsible Party:
|Verinata Health, Inc.
|ClinicalTrials.gov Identifier:
|NCT01708746 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 15, 2012
|Last Updated:
|September 24, 2014
ClinicalTrials.gov processed this record on September 21, 2017


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The book goes on sale today at Barnes & Noble bookstores, The History Center, Amazon.com, www.arcadiapublishing.com and other retailers.
The book contains 227 images from "real photo" postcards — those which feature a real photograph on the front rather than a drawing or other image.
With the images, Harter tried to present a well-rounded view of the city in the first half of the 20th century, from its parks, hotels and government buildings to disasters, local landmarks and street scenes.
"Sadly, tons of stuff had to be left out," said Harter, 62, who began collecting vintage Fort Wayne postcards in 1976 and now owns about 3,000 of them.
For the book, he also had access to another 500 cards in the collections of five other area postcard collectors, who are known as deltiologists.
"The beauty of it is, it really shows how Fort Wayne wanted to be depicted," said John Beatty, a reference librarian at the Allen County Public Library's Genealogy Center.
Along with preserving images of a broad cross-section of the community, Harter's postcards also show what people thought was important at the time, added Beatty, who helped Harter with occasional research questions and also reviewed the book's postcard photo captions for accuracy.
People can see many more of Harter's postcards beginning Nov. 1 via a link on the Allen County Public Library's Allen County Community Album Web page, www.acpl.lib.in.us/database/index/acpl_digital_library.html.
He and his wife, Pat, donated 2,200 of his postcards to the library in 2007, where the cards will be an asset to genealogists and others researching Fort Wayne history. Harter, who is retired from a career in sales and marketing of consumer goods, recently completed digitizing and cataloging 775 of the donated cards to make them ready for online viewing.
Harter has been a Fort Wayne history buff since his early 20s.
"I am one of those people who always liked to look back," he said. "Looking back helps you understand the present."
Since donating his collection to the library, Harter already has picked up another 800 Fort Wayne postcards, buying them at collector postcard sales and auctions, from dealers, and through the Internet.
"It's a fun hobby to have, and I feel I am giving something back to the community by pulling them all together and making them available," he said. "And, it's a hobby that doesn't take much space," he added, grinning.
He hadn't thought of sharing his postcards in book form until his conversation in early summer 2012 with Joel Hyde, owner of Every Other Book, 3208 Crescent Ave.
Along with asking about Fort Wayne history books, he asked if Hyde ever received any old postcards. A puzzled Hyde said no, so Harter explained he had been collecting vintage Fort Wayne postcards for more than 35 years and had nearly 3,000 different postcards.
"That's a book," Hyde said.
After some thought, Harter contacted Arcadia Publishing to see if they would be interested. He knew the publisher had a history book series featuring vintage postcards. He also owns a couple of Fort Wayne history books other local authors have published through the company.
After getting the OK from Arcadia, Harter started work on his book in summer 2012 and completed it by May 1 of this year.
Much of the work involved research to provide brief captions about the buildings or scenes depicted in the postcards used in the book. He had help from staff at the library, History Center and area historic preservation consultant Craig Leonard of Bluffton.
Along with providing facts in the captions, Harter tried to include interesting nuggets of information whenever possible.
"The other thing that was fun about writing it is I knew there would be 'Aha!' moments for people who took the time to read it," he said.
More Information
Postcards photo contestIf you could put Fort Wayne on a postcard, what view would you choose? No matter whether the view is of new or old, we want to see your postcard view of Fort Wayne!
We will pick two winners, who will receive a copy of local author Randy Harter's new book, "Fort Wayne," which chronicles Fort Wayne history from about 1900 to the 1950s as depicted in vintage postcards.
To enter, send your photo on Twitter to @newssentinel with the hashtag #postcardfw and a short description, or email the photo as a high-resolution, JPG image to firstname.lastname@example.com (please put Postcard Contest in the subject line, and include your name and phone number).
The contest begins today. Entry deadline is 5 p.m. Nov. 4. You must be a resident of northeast Indiana and age 13 or older to enter. By participating in the contest, you accept The News-Sentinel's Terms of Use and Privacy Policy.
The winners will be selected based on photo quality and composition. We will publish the winning photos the week of Nov. 4-9 and put others in an online photo gallery for viewing.
For questions, call 461-8347.


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A MAN has been found dead in a home in Dursley after a number of emergency vehicles responded to a 999 call.
Police and several ambulances arrived at the property on Long Street on Saturday, June 28 at around 2pm and found a 44-year-old man unconscious and not breathing.
A South Western Ambulance Service spokeswoman said: "We sent a paramedic in a rapid response vehicle and two ambulances but unfortunately the patient was confirmed deceased at the scene."
A Gloucestershire police spokesman added that the coroner had been informed and they were currently investigating the death, which was being treated as non-suspicious.
Gloucestershire Coroners said formal identification had not yet taken place and were expecting to meet with the bereaved family members on Thursday.


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"Nigel's rich experience in identifying, structuring and negotiating complex, worldwide product licensing transactions, as well as his business leadership skills, will serve Aptalis well," said Mr. Fraher. "His leadership and experience in business development and marketing will enable the expansion of our technology partnerships while providing pharmaceutical companies with the drug delivery solutions they need to advance and protect product portfolios," added Mr. Fraher.
About Aptalis Pharmaceutical Technologies
Aptalis Pharmaceutical Technologies offers a broad portfolio of oral drug delivery technology platforms: Customized Drug Release, Bioavailability Enhancement, and Taste Masking for ODT's (orally disintegrating tablets) and other dosage forms. Together, these technology platforms combined with best in class R&D, formulation development and manufacturing capabilities enable Aptalis Pharmaceutical Technologies to produce customized drug formulation solutions for partners across a range of dosage forms and therapies with high patient acceptability. Aptalis Pharmaceutical Technologies develops and manufactures products, both for itself and for partners, as well as support the drug development process for the Aptalis Pharma pipeline and portfolio of products. For more information about Aptalis Pharmaceutical Technologies, visit www.AptalisPharmaTech.com
About Aptalis
Aptalis Pharma Inc. is a privately held, leading specialty pharmaceutical company providing innovative, effective therapies for unmet medical needs including cystic fibrosis and gastrointestinal disorders. Aptalis has manufacturing and commercial operations in the United States, the European Union and Canada, and its products include ZENPEP®, CANASA®, CARAFATE®, PYLERA®, RECTIV®, VIOKACE™, ULTRESA™, LACTEOL®, DELURSAN®, PANZYTRAT®, and SALOFALK®. Aptalis also formulates and clinically develops enhanced pharmaceutical and biopharmaceutical products for itself and others using its proprietary technology platforms including bioavailability enhancement of poorly soluble drugs, custom release profiles, and taste-masking/orally disintegrating tablet (ODT) formulations. For more information, visit www.aptalispharma.com.
Media Contact:
Erin O'Brien, Director of Marketing
Aptalis Pharmaceutical Technologies
908-927-9600, Ext. 4084


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After waiting many years for the news, it is finally announced that Roger Waters The Wall Live DVD will be getting screened at the Toronto International Film Festival from 6th September 2014.
The movie of the Wall Live shows, which were performed from September 2010 to September 2013, will no doubt have lots of footage from the concerts and other materials that have been filmed recently by Roger Waters – like his visit to his father's grave in Italy that featured a film crew.
As more information becomes available it shall be posted on this website and probably more in depth on our sister website Neptune Pink Floyd.
Check out our latest story on the Roger Waters Live Film DVD.
Once the DVD and probably Blu-Ray are released, expect a full review and updated about the contents of the new Wall Live DVD/film. I imagine there will be all kinds of goodies on there for us fans to enjoy, with not much being released over the last few years, and most of it being repackaged materials, it is nice to get something fresh, new and exciting!


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Return to article: MSU engineering students win second place at construction estimating competition
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text:
And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
No need to get lengthy with motivational rhetoric and inspirational quotes. Say it short and sweet with this letterpress print. The sturdy piece is simply printed with "Heck Yes." And that's all there is to it.
- Printed with black foil stamp
- Archival-quality, reclaimed cotton paper
- Measures 8" x 10"
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** This item may have additional shipping charges applied at checkout.
If you're not happy with this item for any reason, you may return it for a full refund within 14 days.


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McDonald's burgers losing their allure
McDonald's has reported its first monthly drop in global sales in almost a decade as diners turn their backs on the golden arches in favour of its price-conscious competitors.
The fast-food giant reported a 1.8 per cent slump in sales during October, the first monthly decline since March 2003, sending its shares to a year low and presenting big challenges to its new CEO.
McDonald's is likely to answer the challenge with stepped-up promotions in response to resurgent rivals such as Burger King, Wendy's and Taco Bell, analysts said.
Those chains have re-done their menus and beefed up "value" offerings to compete with McDonald's popular Dollar Menu.
McDonald's is in many ways a victim of its own success said analysts, who for now are giving a pass to new CEO Don Thompson. Thompson took the helm at the world's biggest hamburger chain on July 1.
McDonald's for years has set the bar for growth by outpacing rivals and turning in strong sales despite modest consumer spending around the world.
The seller of Big Macs and Chicken McNuggets last month signalled an October sales decline because of the weak global economy, which has spurred intense competition in response to diners' diminishing appetite for spending money on restaurant food.
"This has nothing to do with Don being in charge. It's just a matter of bad timing and bad luck. They'll get through it," Edward Jones analyst Jack Russo said.
He predicted that McDonald's would respond with more promotions this month, but he also said superstorm Sandy, which hit the US Northeast at the end of October, was likely to weigh on November sales.
October sales at McDonald's restaurants fell 2.2 per cent in both the United States and Europe, but dropped 2.4 per cent in the Asia-Pacific region, Middle East and Africa.
With more than 34,000 locations around the world, McDonald's has far more purchasing and advertising muscle than many rivals, analysts said.
Still, it will be difficult for McDonald's to post higher same-restaurant sales for November and December because last year's results were so strong, analysts said.
McDonald's shares touched a 52-week low of US$85.64 on Thursday. They were down 1.2 per cent at US$85.79 in Friday trading on the New York Stock Exchange.
October sales at McDonald's restaurants open at least 13 months fell 2.2 per cent in both the United States and Europe, and dropped 2.4 per cent in the Asia/Pacific, Middle East and Africa (APMEA) region.
While the sales declines were expected, they were steeper than Wall Street estimated in the United States and Europe.
McDonald's US market share losses "seem to have accelerated in recent months," Jefferies & Co analyst Andy Barish said in a note to clients.
Many US restaurant companies, including investor favorite Chipotle Mexican Grill and McDonald's, have reported cooling demand as diners get more frugal.
Just a few weeks ago, McDonald's posted its worst quarterly restaurant sales growth performance in nine years.
Those results come as Wendy's, the second-largest US hamburger chain, leaps weak year-ago results with help from a turnaround effort that includes re-doing both its menu and restaurants.
On Thursday, that chain reported a 2.7 per cent increase in third-quarter sales at established company-operated restaurants in the United States.
Wendy's stock jumped 5.8 per cent to US$4.51.


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I can attest to its popularity, as I have spent many Friday or Saturday nights there waiting with others in the lobby for a table. A word of warning: It can be chilly there.
When we went on Wednesday, seating wasn't a problem. We were ushered into the bar side, which is dimly lit and cozy, with many photographs of former patrons on the wall.
Just about every time we go to Nine Mile, we see neighbors or friends. Wednesday was no exception. Our friends were there to pick up a to-go meal, so they sat at our table while they waited.
A sign in the bar says Nine Mile is the oldest bar in Indiana, established in 1837. According to Nine Mile's website, it got its name because that's the distance between the tavern and the Allen County Courthouse.
It does feel like a roadhouse, as it's kind of out in the middle of nowhere. Its lighted sign is a welcome beacon on a dark, cold night.
The menu is varied and should satisfy the meat-and-potato lover, those who prefer fish or seafood, and the health-conscious who gravitate toward salads.
My companion and I started with appetizers. I ordered something I'd never tried — fried pickle spears with a Cajun-ranch-horseradish sauce. Five large, crispy, hot, breaded pickle spears were delivered to my table with a slightly sweet and tangy dip. Salty, sour, delicious, they made me pucker up. I could only eat two.
My companion ordered an appetizer of battered, deep-fried chicken gizzards. He polished off about two-thirds of the plate and said they were lightly battered and seasoned, not greasy, and tender. The barbecue sauce complemented them well, he said, and, when he warmed the leftovers in the microwave, they were almost as good as when they were first served.
As for me, I would not touch a gizzard with a 10-foot pole.
Wednesdays are Mexican night at Nine Mile, so I ordered the chicken enchiladas, which came with rice and beans. The enchiladas were filled with spicy chunks of chicken and topped with sour cream, black olive slices and diced tomato. The rice was slightly spicy and a nice accompaniment to the enchiladas.
My companion ordered a dinner that came with two sides. One of his choices was a favorite of his — Nine Mile's spinach salad, made with fresh spinach, crumbled bacon and crumbled boiled egg, and served with Nine Mile's own sweet oil-based dressing.
His entr�e was an 8-ounce sirloin, which he said was "just a sirloin" — cooked medium, as he requested, and fairly tender. It was accompanied by Nine Mile's buffalo chips, which are thinly sliced ridged potatoes coated in Buffalo sauce or seasoning and deep-fried. They aren't too spicy, but retain the flavoring from the seasonings.
Based on past experience, I also can recommend the fried fish at Nine Mile and my favorite entr�e, grilled shrimp stuffed with crab meat. The shrimp are small, but buttery and rich.
When Carol went to Nine Mile 10 years ago, she marveled at its "retro-ness" — in particular, the thick slice of Texas toast Nine Mile serves with most entrees.
In those 10 years, some things have changed at Nine Mile, including a major interior remodeling a few years ago. But I'm happy to say much is still the same, from the friendly wait staff to the chicken gizzards to the Texas toast.
Not everything's perfect there — service suffers a little when it's very busy. Recently on a cold night, I sat at a table closest to the lobby, where I could feel a draft of cold air every time somebody went in or out the door. I kept my winter coat on during the meal.
Overall — well, when a place has been in business since 1837, it's safe to say they do most things right.
Every other Tuesday, Cindy Larson describes a one-time dining experience at an area restaurant. The News-Sentinel pays for meals. This column is the personal opinion of the writer and does not necessarily reflect the views or opinion of The News-Sentinel. You can reach her at 461-8284 or firstname.lastname@example.com. To read other columns, go to www.news-sentinel.com/ section/LARSON.
More Information
Nine Mile RestaurantWhere: 13398 U.S. 27 S.
Hours: 6 a.m.-11 p.m. Monday-Thursday; 6 a.m.-midnight Friday-Saturday; and 11 a.m.-9 p.m. Sunday
Phone: 639-8112
Alcohol served? Yes
Credit cards accepted? Yes
Website: www.ninemilerestaurant.com
Menu sampler:
•Homemade onion rings, $5.99
•Fried pickle spears with sauce, $4.99
•Chicken gizzards with sauce, $5.99
•Spinach salad, $3.19 or $6.99 for large
•Chicken Caesar salad, $7.99
•Grilled chicken and BLT salad, $8.99
•Prime rib with two sides, $16.99
•Two pork chops with two sides, $9.99
•Baby back ribs with two sides, full rack $18.99; half rack $11.59
•"Mess of lake perch" fried with two sides, $12.99
•Beer-battered cod with two sides, 4 piece, $13.49; 3 piece, $11.59; 2 piece, $9.49
•Grilled shrimp stuffed with crab meat with two sides, $10.59
•Nine Mile burger with grilled onions and Swiss cheese on a Kaiser roll, $7.29
•Nine Mile club sub, $7.99
•Grilled chicken club sandwich on a Kaiser roll, $7.29
•Hot ham and Swiss sub, $7.59
•Italian roast beef sub, $7.99
•Two-item pizza, 10-inch, $7.59; 12-inch, $10.29


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After seeing the show on Broadway almost four years ago, Purple Rose Theatre's Artistic Director, Guy Sanville, wanted to bring "33 Variations" to his theater home.
Sanville wasn't crazy about the Broadway production starring the legendary Jane Fonda because of its "overproduced" elements such as numerous slides and projections, but he loved the story by Mois�s Kaufman.
As the show's director, Sanville decided to make the Purple Rose rendition of the show much simpler and let the story speak for itself.
"It's a collage almost. It's bare bones with very few props and set pieces," said Sanville. "It's simply elegant and beautiful -- a simple, lyrical legato."
FYI: Previews for "33 Variations" begin Thursday, March 28, and run through April 4. Showtimes are 8 p.m. Thursday, March 28 and Friday March 29; with a 3 p.m. matinee at and evening performance at 8 p.m. Saturday, March 30; 3 and 8 p.m. Wednesday, April 3; and at 8 p.m. Thursday, April 4, with low-priced tickets available. The show opens on April 5 and runs through June 1. Showtimes are at 3 and 8 p.m. Wednesday; 8 p.m. Thursday and Friday; at 3 and 8 p.m. Saturday and 2 p.m. Sunday. Tickets are $22 to $42. Visit www.purplerosetheatre.org or call 734-433-7673.
The plot explores Katherine Brandt's journey as a musicologist to understand Ludwig van Beethoven's obsession with a simple waltz as his deafness grows, while also coping with her progressing ALS and the state of her relationship with her daughter.
Jumping from Beethoven's time to the present, the play often requires actors to inhabit the same space as Beethoven and the present-day characters' storylines intertwine.
The Beethoven element of the show caused Sanville to examine his relationship with the composer's music during the preparation and rehearsal for the show.
"I realized what a slobbering Neanderthal I really am," the director joked. "My musical taste is very eclectic. But, I wasn't a huge fan of Beethoven until I began to really listen to the variation and journey of Beethoven's 'Ninth Symphony', for example. It is remarkable that he created some of his best stuff after he was deaf."
"He changed music forever and I know it sounds clich�, and the word gets overused, but he was truly a genius," Sanville continued.
Sanville's approach to "33 Variations" as the director was to stay true to Kaufman's text and�allow the�the physical context of the show to�complement the words.
"Directors look for a way to inform the physical context with the text -- this show is very text driven," said Sanville. "There is a certain rhythm and pulse and I try to live those moments as simply and truthfully as possible."
"I try to tell the story and not impose a certain idea or concept because everything we need is right there in the script," he added.
While everything needed to direct a show might lie within the text of the script, the opportunity to interpret something new and react on personal level is always there as well. �And Sanville has learned that embracing a concept or feedback off stage is part of the process.
"When someone gives me a note or suggestion that makes me mad, I've learned that is the one that I need to take," he said.
The director has plenty of expertise around him from which to receive suggestions at the professional, Chelsea, Mich.-based theater founded in 1991 by actor and native Jeff Daniels.
Beethoven's genius and Katherine's life journey blended with Sanville's passion and the expertise of the staff at Purple Rose Theatre make "33 Variations" a destination for frequent theater goers or those who want to experience it for the first time.
"The show is a celebration of life. It's a simple story, beautifully told and accessible to anyone who chooses to come see it," said Sanville. "It is emotionally fulfilling -- after our first read-through, I wasn't even expecting to have the reaction I had. I want whatever I see to take my breath away and this show does that."
David Bendena of Chelsea, Daniel C. Britt of Hamilton, Ohio, Lauren Knox of Macomb, Richard McWilliams of Dayton, Ohio, Michelle Mountain of Grass Lake, Michael Brian Ogden of Berkley and Rhiannon Ragland of Flint perform in the production.
Samantha White is a Detroit-based freelance writer. Contact her at firstname.lastname@example.com.


text: Cena wins this year, decider at mania 30. It just makes Sense I just wish they would make one a fucking heel it's boring the shit out if me. I mean it's the most pessimistic I have ever gone into a mania as regards to the quality of the show. We know Cena will win but make him do it as a heel (save the 'Cena will never turn heel' responses I understand this but if they are building Ryback to be the face of the company and merchandise seller then why not, grow some balls). Or even better let rock go heel for it I fucking love rock as heel.


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Study of Doxil in the Treatment of Patients With Refractory Idiopathic Thrombocytopenic Purpura
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2005 by Hematology and Oncology Specialists.
Recruitment status was: Recruiting
Recruitment status was: Recruiting
Hematology and Oncology Specialists
Information provided by:
Hematology and Oncology Specialists
ClinicalTrials.gov Identifier:
First received: April 11, 2005
Last updated: June 23, 2005
Last verified: April 2005
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This study is designed to evaluate the efficacy and safety of single agent Doxil in the treatment of patients with refractory ITP (Idiopathic Thrombocytopenic Purpura).
|Autoimmune Thrombocytopenic Purpura
|Drug: Doxil
|Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Phase II Study of Doxil in the Treatment of Patients With Refractory Idiopathic Thrombocytopenic Purpura
Resource links provided by NLM:
Drug Information available for: Doxorubicin Doxorubicin hydrochloride
Genetic and Rare Diseases Information Center resources: Immune Thrombocytopenia Idiopathic Thrombocytopenic PurpuraU.S. FDA Resources
Further study details as provided by Hematology and Oncology Specialists:
Primary Outcome Measures:
- the primary outcome would be a platelet response, with a return of platelet count to normal
|Estimated Enrollment:
|Study Start Date:
|September 2001
|Estimated Study Completion Date:
|April 2005
Eligible patients will receive Doxil 20 mg/m2 IV over 1 hour every 2 weeks. Treatment will be continued for 1 course beyond return of the platelet count to normal with a maximum of 18 courses.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Thrombocytopenia with bone marrow findings showing normal or increased numbers of megakaryocytes.
- Failure to respond to initial treatment with steroids, IV immune globulin, splenectomy and post splenectomy steroids.
- Platelet count of 30,000 or less.
- Performance status score of 2 or less.
- Adequate organ function: *bilirubin< 2; *AST < 3 times normal; *creatinine < 2.
- No prior treatment with anthracycline or chemically related drugs.
Exclusion Criteria:
- Pregnant or lactating women.
- Presence of a malignancy other than basal cell carcinoma of the skin.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00107913
Please refer to this study by its ClinicalTrials.gov identifier: NCT00107913
|United States, Louisiana
|Hematology and Oncology Specialists
|Metairie, Louisiana, United States, 70006
|Contact: Mary Ann Ostroske, RN 504-894-7115 ext 221 email@example.com
|Contact: Avri Haggerty, MT 504-883-2968 email@example.com
|Principal Investigator: Thomas M Cosgriff, MD
Sponsors and Collaborators
Hematology and Oncology Specialists
|Principal Investigator:
|Thomas M Cosgriff, MD
|Hematology and Oncology Specialists
More Information
Keywords provided by Hematology and Oncology Specialists:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00107913 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 11, 2005
|Last Updated:
|June 23, 2005
Keywords provided by Hematology and Oncology Specialists:
Immune Thrombocytopenic Purpura
Additional relevant MeSH terms:
Purpura, Thrombocytopenic
Purpura, Thrombocytopenic, Idiopathic
Blood Coagulation Disorders
Hematologic Diseases
Pathologic Processes
Skin Manifestations
Signs and Symptoms
Thrombotic Microangiopathies
Blood Platelet Disorders
Immune System Diseases
Hemorrhagic Disorders
Autoimmune Diseases
Liposomal doxorubicin
Antibiotics, Antineoplastic
Antineoplastic Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017


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« Back to Schedule |
Print Camp Details
| Download Camp Waiver Form
Ages 14-18
Location: Cougar Field-Houston, TX
Saturday, August 3, 2013 to Sunday, August 4, 2013
Starts: 9:00am / Ends: 4:00pm
Camp Cost: $225.00
The Summer Showcase Camp is the perfect setting to improve your skills and showcase your game to college coaches and professional scouts.
Created specifically for high school players, campers will display their skills in a Pro Style workout, defensive showcase and batting practice. Campers will also be given the perfect opportunity to display their abilities to live games for the camp staff.
Camp personnel will include UH baseball staff along with other college coaches and professional scouts. This camp is designed for the player who is serious about taking their game to the next level and who desires "exposure" to college coaches.
Cougar Baseball Camps are designed to help improve the performance of baseball players of all ages and skill levels. Campers will receive instruction from some of the top coaches in the country who care about the betterment of each individual player. Cougar Baseball Camps are dedicated to the development and growth of all campers who attend.
Check in will start 45 minutes before camp on Monday. Each camper will need to have his medical release filled out and signed before they will be allowed to participate in the camp. Lunch for the full day camps will be available for purchase each morning at the front of the stadium.
Our camps range in ages and we have a program to fit your needs. If you do not see a date that works for you at this time please check back to the site as we add new sessions often.
Here at the University of Houston be will be using beautiful Cougar Field for drills and games throughout the camps along with Yeoman Indoor Facility and the UH Batting cages down the LF line. Camp will be held rain or shine.
What to bring
All campers will need to bring their own glove, bat, helmet, batting gloves, baseball hat, turf/tennis shoes (cleats are optional), and catchers equipment (if needed for camp). Please make sure the campers name is clearly printed on all pieces of equipment that he brings to camp. All other equipment will be provided.
Please make sure you sign up using an email account that you frequently check as this will be how I get information about the camps to you. Having the proper email account will help to eliminate any miscommunication.
Per NCAA rules all camps and clinics held by the University of Houston are open to everyone, enrollment is only limited based on age, grade level or number restrictions be each camp.
Please make sure that you know the drop off and pick up times for your camp. Check in will start 45 minutes prior to the beginning of each camp on Monday's only. All campers will receive a t-shirt at sign in the first day of camp.
Waiver & Medical Release Form will be attached to your e-mail confirmation. It is also available in this camp listing.
Please print fill out, sign and deliver this form to the registration check in on the first day of camp. You will be unable to attend camp without this form.
Download Waiver Form
Cougar Field
3100 Cullen Blvd
Houston, TX 77204
Parking for Cougar Baseball camp can be found across the street (Cullen) in the lot behind the RF wall, this parking is free.
There will be UH merchandise (hats, shorts, DVD's) for sale each day of camp, the table will be set up in the mornings at drop off, lunch and again at the end of the day for pick up.
What if I have to cancel a camp? We do not offer refunds on canceled campers, just a future camp credit if you decide to cancel, but we do have what is called "Cancellation Protection". We offer basic Cancellation Protection to allow participants some peace of mind in case plans change. This allows us to keep our prices low and provide the best service possible. Due at the time of registration, Cancellation Protection entitles you to a full refund of camp fees should you cancel your registration more than 14 days prior to the start of an overnight camp, and 7 days prior to the start of a day camp. If you cancel within 14 or 7 days of the start of your session, we will give you a camp credit for all money paid. The credit is valid for three years from camp date at any of our camps. Credit with insurance is transferable to family members or friends, and good toward a future camp.
Full time trainer on duty throughout completion of camp.
Please email any questions to email@example.com or call 302-584-7926
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LIVERMORE — Sometimes, you can go home again.
For U.S. Navy veteran Mathew St. Denis and his wife, Leah, that moment came Friday when their family was officially presented with a newly refurbished home in Livermore from Habitat for Humanity East Bay/Silicon Valley.
Both Mathew — who served in the Navy until 2007 — and Leah grew up in Livermore, but the rising cost of housing had forced them to rent a home in Tracy. Soon, rather than making the long commute every day, Mathew will be able to ride his bike to his job at a local cable company.
"The biggest reason why it's so unbelievable is because it's Livermore," he said. "It's coming back home essentially. It's really big for us."
The St. Denises signed their purchase contract and disclosure forms after a dedication ceremony in the backyard of their new home and are scheduled to move in after escrow closes in mid-September, just in time for the birth of their fourth child.
Leah St. Denis said she had given up hope that their family could ever afford to move back to her hometown, until they saw a call for veteran families to apply for the first-time homeownership opportunity in January. Through the program, the house required no down payment, just 250 hours of "sweat equity."
"We just kept meeting all the qualifications," she said. "I think I'll believe it when the moving truck finally pulls up. It's just too good to be true."
Work on the nearly 60-year-old, formerly dilapidated house on Andrews Street was done over nine months with the help of about 300 volunteers from Sandia/California National Lab in Livermore, Dow Chemical in Pittsburg, the local faith-based community, neighbors, and various local businesses. Altogether, volunteers contributed at total of 2,300 hours to the project; even Congressman Eric Swalwell, D-Dublin, and Livermore Mayor John Marchand pitched in gutting the house.
"This was the community coming together to serve those who served our nation," Marchand said. "This house was a blight on the neighborhood. We were able to acquire it and turn it around so a young family can move in. … To see the transformation is just incredible."
Friday's dedication drew about 100 volunteers, Habitat for Humanity representatives, city leaders and community members who had helped with the rebuild. The St. Denis family was presented with a hammer to symbolize the volunteers' work, along with a Bible, an American flag and an oversized key to the home.
Habitat for Humanity bought the house for $375,000 as a foreclosure; the city of Livermore helped select the site and contributed money for the purchase from an affordable housing trust fund. At the time of its purchase, it was abandoned, dilapidated, and had issues with squatters and code violations.
Janice Jensen, president and CEO of Habitat for Humanity East Bay/Silicon Valley, said the house was "one of the worst I've ever seen."
"This home was in such rough shape when we got it," Jensen said. "To say it was the dog on the block is a disservice to dogs."
According to Jensen, the neighborhood, the finished product and the family who received it were all a perfect fit for the group's mission.
"This is a community effort, and to me, that's what Habitat for Humanity is all about," she said.
The St. Denises' home is one of 50 the local Habitat for Humanity chapter plans to build, renovate, or repair this year, and one of the first for the group under the Veterans Build homeownership program, a national program targeting veterans and their families.
The nonprofit is on track to serve 10 local veteran households with home repairs this year and one to two veteran households through homeownership, including renovations and new home construction, according to spokeswoman Erin Spaulding.
Contact Jeremy Thomas at 925-847-2184. Follow him at Twitter.com/jet_bang.
Habitat for Humanity East Bay/Silicon Valley provides home repairs and homeownership opportunities to low-income families and to veterans through the national Veterans Build program. The organization is currently taking applications for a rehabilitated home on Ruth Way in Livermore, with veteran applicants preferred. Veterans can call Meghan Shea for more information at (510) 803-3313. To volunteer with Habitat for Humanity, visit www.habitatebsv.org or call 866-450-4432.


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I read a great story this morning on Apple's Hot News RSS feed. Since I'm in a train geek + Apple geek family, to see the two geeky pleasures combine to make train travel easier was like, well, chocolate and peanut butter combining to make Reese's cups!
This article has been reproduced in a new format and may be missing content or contain faulty links. Contact firstname.lastname@example.com to report an issue.
By the end of this summer, Amtrak will have fully transitioned to a digital ticket scanning capability. Amtrak conductors will use Apple iPhone bar code scanners to read passengers' tickets and manage their manifests. These iPhones will be replacing the decades-old tradition of manually punching train tickets. Perhaps you've seen some of your train conductors using the scanners already.
This upgrade will also help conductors more easily manage available seating on a train and will help Amtrak's central processing better manage last minute schedule changes, disabled passengers, and statuses of train maintenance.
Most of me is exclaiming, "It's about time!!!" Think about how far airlines have come with bar-code scanning of boarding passes. I can now fly Delta airlines with only the barcode on my email ticket confirmation out of some airports. I think that's awesome and will save so many trees. Amtrak is headed in that direction, particularly with their still-evolving mobile app for iOS devices and their mobile site for other smartphone platforms.
Yet, there's a part of me that will miss the tradition of manually hole-punching train tickets. For those who have seen the film version of The Polar Express and those scenes of the Conductor whimsically punching words into the tickets, I can say I have experienced train travel with similarly skilled conductors who will punch words and pictures into my and my kids' tickets. Part of the fun of traveling on the Long Island Rail Road was seeing what shaped hole-punch the conductors had on that day. Crescent moon? Heart? Triangle? Star?
Read more about the Amtrak transition to digital rail passenger management at the New York Times.Go Back to Top. Skip To: Start of Article.


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Clarity in Diamonds ~ One of the Four C's
Four attributes determine the price of a diamond: Clarity, Color, Cut, and Carat. The famous Four C's. One of the first things most people learn about diamonds is that not all diamonds are created equal. In fact, every diamond is unique. Diamonds come in many sizes, shapes, colors, and with various internal characteristics.
Internal Features
Few things in nature are absolutely perfect. This is as true of diamonds as anything else. Diamonds have internal features called inclusions, and surface irregularities called blemishes. Together, they're called clarity characteristics. Clarity is the relative absence of inclusions and blemishes.
Among other things, blemishes include scratches and nicks on a diamond's surface. Inclusions are generally on the inside, and some might break the surface of the stone. Sometimes, tiny diamond or other mineral crystals are trapped inside a diamond when it forms. Depending on where they're located, they might remain after the stone has been cut and polished, and they can affect a diamond's appearance.
Diamond Terms
Diamond professionals use a set of terms that originally included very very slightly imperfect, very slightly imperfect, slightly imperfect, and included. These terms were shortened to the initials VVS, VS, SI, and I. The abbreviations are now accepted throughout the international diamond community.
Eye Clean
As a consumer don't judge a diamond totally on it's specifications. It should be what a jeweler calls "eye clean", which means what the naked eye can see, with plenty of sparkle. It shouldn't be cloudy or have visible inclusions. And any inclusions at the center of the stone should be avoided! Is there an inclusion on the side that could be covered with a prong? Your jeweler can help with these decisions.
Clarity is one of the factors that proves bigger is not necessarily better in a diamond. A clean, sparkly 1/2 carat stone is much more appealing than a 3/4 carat stone that's cloudy…
Find Your Perfect Diamond
Pyramid's professional Jewelers, David and Don Herrington, have years of experience helping customers find the perfect diamonds for rings, pendants and earrings. They can help you find the perfect stone for your taste, fashion and budget. Contact us today to get started! Email Us Here or give us a call at 207-667-3321


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Our goal is to ensure that every customer, and every implementation of our products is successful. That's why we provide multiple support options, to give your organization the right level of support, at the right place, when you need it.
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Ira Ryan, stoic and plain and obsessed with just putting his head down and working, is the prototypical Midwesterner. He has a penchant for tough conditions, overcoming hardships and persevering in the face of adversity. He loves bad weather, long distances and challenging road surfaces as though he lives and rides in fear of comfort and complacency.
Ira started building bikes four years ago after apprenticing with Sacha White of Vanilla Bicycles. Ira's workshop is in the basement of a bike shop five miles north of Portland in a neighborhood called St. Johns.
How did you get here? What led to Ira Ryan Cycles?
I've worked in restaurants, washing dishes and prepping food. I've been a carpenter. I helped start Magpie Messenger Service, a Portland, Oregon courier collective. I've been working on bikes since I was 17, on my own bikes, as a shop mechanic, and now as part of Ira Ryan Cycles.
What is epic, or what does it mean to you? What makes that experience?
Epic is a 20-mile ride in the rain with three flats and lots of mud. Sometimes it's rain, gravel, climbing, or cookies and coffee in the middle of nowhere. Really it's as much about your state of mind as where you are and what you are doing. The rider makes the experience and the bike is just the ultimate accessory.
I grew-up riding 21-pound steel race machines, bikes you could ride hard and put away wet. After a race, we'd throw them into the back of a truck, not worried about paint or our carbon bars breaking. In the last 20 years it's seems like bikes and riders both are little less hard. The heroic hard-man mythology, the Euros' and their spring classics, continue to motivate me, though I think it's being diluted by plastic bits and flammable parts. I like down-tube shifters, lugged steel and riding without a helmet, but that's just me. If a carbon bike works for you, grab your 10-speed ride and let's go suffer some cobbles together.
What inspired you to build? What does the craft mean to you?
Riding a bike up one side of mountain and down the other on a bike that I made with my own two hands—using nothing but simple tools, fire and metal tubes—is my greatest achievement. I love that my craft hasn't changed much in generations. What I'm doing and the way I'm doing it, is the same way my grandfather, had he made bikes, would have done things. That feels good. It feels solid. I think the best tool in the shop is the builder's hands. I think relying too heavily on technology to support your design and technique is risky. Quality is elusive, everywhere you look and in so many aspects of our daily lives, and I think independent bicycle frame builders are doing something small to change that.
What are a few of your greatest experiences on a bike?
Rolling into the darkness on never ending rolling hills and back roads covered in gravel with 180-miles down and another 130 to go. Having just dropped the main field, in the lead now and on target to win the first Trans Iowa, or Tranny. Riding with my friend Ricky up Lolo Pass in the spring to find gravel and ice on the descent into Hood River. It was our first time riding all the way there from Portland. We stopped in Hood River to eat McDonalds before turning around and motor pacing 18-wheelers and traffic on I-84 the whole way home, just barely beating sunset. I think it was 130-miles total. A group ride in Iowa with a tornado behind us, pace lining at 43mph with a killer, literally, fucking tailwind chasing us the whole way. Riding 750-miles from San Francisco to Portland in four days, sleeping in a ditch four hours a night, as part of a Raid Race. Hell, even riding Saltzman the other day is a favorite.
For more information visit: www.iraryancycles.com
Continental Bike


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its not victor cruz.
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its not victor cruz.
Counting down the days untill DJ Augustin's contract expires.
#colts owner Jim Irsay to media at owners' meetings:"it's not (Victor) Cruz, no". So that's one name to cross off the list.— Mike Chappell (@mchappell51) March 17, 2013
And if it costs us our No. 1??
Ever notice how friendly folks are at a shootin' range??.
cruz was the only way we were losing a 1st
Why so SERIOUS
Not going to get too excited about this at all. My prediction at some point will be Heyward-Bey is the new Colt. Hope everyone can point a laugh at my guess when all is said and done.
You know how hippos are made out to be sweet and silly, like big cows, but are actually extremely dangerous and can kill you with stunning brutality? The Pacers are the NBA's hippos....Matt Moore CBS Sports....
Yeah judging how happy and excited Jim was for some signings earlier, I wouldn't be surprised at all if it was some serviceable WR. Not that I will have a problem, if he turns out to be really good. All I'm saying is that it probably won't be a big name as some expect.
I'm thinking its Maclin
I thought he quit his job....as an FBI agent.
PS:Sorry but had to.
I would love if the Bears signed him and let Hester go. I know that won't happen we are pretty cap strapped.
They said no Cruz and Hayward Bey
What's your source for "they said no Hayward Bey"?
I know we have a tweet that says "No Cruz".
I've always sorta suspected the target was Fitzgerald.
There are two types of quarterbacks in the league: Those whom over time, the league figures out ... and those who figure out the league.
I don't see how the Cards could afford to trade Fitzgerald. Here's an article that says trading him would create $15 million in dead money. And I don't think that includes the $10 million option bonus that was due last Friday (per Rotoworld).
Last edited by Strummer; 03-18-2013 at 04:48 PM. Reason: last becomes that
IS JMV saying that the "deal" is dead or did I misunderstand what he said?
Ever notice how friendly folks are at a shootin' range??.
According to this guy is Desean Jackson
Jackson is too similar to Hilton for me to believe that
Don't ask Marvin Harrison what he did during the bye week. "Batman never told where the Bat Cave is," he explained.
I'd take either Macklin or Jackson for the right price.
There are two types of quarterbacks in the league: Those whom over time, the league figures out ... and those who figure out the league.
Maclin. No thanks to DeSean.
Honestly, I'd rather just draft a WR. Take a chance on Justin Hunter. Trade down to get him.
Then move up in the 3rd to get Barret Jones, if he's still around.
First time in a long time, I've been happy with the team that was constructed, and now they struggle. I blame the coach.
I'm starting to wonder if this particular deal is dead and the Hassleback signing will be the final addition to the team before the draft.
i think the deal is probably dead!!!
If it's a trade then I think it's probably dead.
If it's a free agency signing then I think the Colts have probably submitted their final offer and are waiting for the player to make a decision.
If it's a RFA signing then the player may be afraid his old team will match. So he might be waiting for them to spend some more money on other players to make matching less likely.
Irsay needs to STFU. Don't get fans all in a tizzy to have the deal go all fizzly.
First time in a long time, I've been happy with the team that was constructed, and now they struggle. I blame the coach.
Is my memory getting bad or at some point in the last few days did someone say/tweet something about "waiting for the price to come down"?
If so, that makes me wonder if the deal is (was?) one that was contingent upon a long term deal being signed like the Percy Harvin deal between the Vikes and Hawks? Maybe the Colts and Team X have (had?) already agreed on the compensation picks and the hang up is (was?) working out a long term deal with the mystery receiver?


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This page is about the slang term ill
Meaning: good, excellent
For example:
- The new Neo album is ill, man!
- Corrie's new jacket is ill. Where can I get one?
This usage is fairly obscure U.S. teen slang and it's not widely known or understood in the larger community.
Variety: This is typically used in American English but may be used in other varieties of English too.
Quick Quiz:
I heard some kids saying the new Batman movie was ill. This means they think it's
This entry is in the following categories:
Contributor: Matt Errey


text: Whether you're the bride-to-be, wedding guest, or bridesmaid, Gilt's newly launched wedding boutique pretty much has you covered in every style category. The bridal destination currently houses a glamorous array of designer gowns and accessories — from the likes Marchesa, Reem Acra, and Badgley Mischka, to name a few — marked up to 75 percent off. Meanwhile, the wedding party is supplied with chic dressing options for women and men, and for the guests, there's a ton of pretty pieces to choose from too. With prices this ridiculously discounted, sizes are limited, so we suggest you act fast. Click on for our top picks from Gilt's wedding event, and then get shopping!


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What's on your to-do list today? If you're like most dairy farmers, the list includes a healthy dose of tasks geared toward making milk, feeding and breeding cows, equipment repairs and the like. But don't forget to include items that contribute to knowledge about your business and the outside factors that impact it. You still need to manage the day-to-day duties on your dairy; those items are critically important. But honing your business skills has become vitally important, as well.
Results of a research project conducted in Pennsylvania several years ago indicated that owners of profitable dairy businesses had better-quality records and spent more hours per week managing their businesses than owners of unprofitable dairy businesses. Therefore, if you are not acting as the chief executive of your business, you should be, especially given the current state of the industry.
Here's why you need to change your management focus from tasks to knowledge.
Executive mind-set
With many farm businesses now multi-million dollar operations, and the operating risk in agriculture increasing, farmers need to spend more time on the managerial and financial sides of their business, notes Mike Boehlje, agricultural economist at Purdue University. You've got to be thinking about things like profitability, capital structure and debt service, size and growth, risk and financial documentation and creating value for your shareholders (who are usually family members).
Your skills and talents need to match the needs of your business. This means you need to approach the size and growth of your business from more than just a capital position, he adds. "You also have to worry about your managerial skill set," he notes. "You have to continually focus on the right way to grow, as well as make sure the resource base is there to grow successfully."
Strategy vs. tactics
If you plan to be a long-term player in the dairy business, you must think in terms of the organizational focus of your business, or in other words, the drivers of your daily and long-term decision-making.
All decisions are not created equally, but all must be carefully analyzed, maintains Brad Hilty, Penn State Dairy Alliance information management specialist. These are the to-do list items than stretch your management skills and get you headed on the path of a business executive.
For example, good managers know whether a decision is tactical or strategic in nature.
Strategic decisions are those that focus on doing the right things for your business to achieve long-term goals like improving profitability, improving cash flow or building a retirement fund, he explains. There are different levels of strategic decisions, but all are focused on doing the right things. Decisions of this nature include expansion plans, whether to hire a custom operator or even the implementation of a synchronized breeding program.
Tactical decisions, on the other hand, are more about doing things right than doing the right things. These are usually daily or frequent decisions, like ration changes or forage harvest timing.
Therefore, while tactical decisions are essential to your business, you also need to focus on your strategic decisions because that's where you take your skills from tasks to knowledge.
The well-known economist and business-management expert, Peter Drucker, realized the emerging importance of knowledge in business and society decades ago. Drucker noted that "the emerging reality of the 21st century will be that those businesses which are organized around knowledge, rather than tasks, will have the opportunity to create wealth."
Continuous improvement
There is no silver bullet, but business success is achieved through continuous improvement that keeps the best performers ahead of the pack, says Matthew Oesch, associate business consultant at Lookout Ridge Consulting.
"Our experience has shown that a key trait of excellence is the courage to confront brutal facts and change course if necessary," he says. "Comparatively, less-than-spectacular performance often results from failing to acknowledge changing market circumstances or internal business weaknesses. The key is being a student of your industry and your business, and be willing to adjust when exposed to new information."
Think about what drives the daily and long-term decisions of your business in that context. "Is the driver tasks or knowledge?" Hilty asks. "If it is the former, perhaps it is time to change. Knowledge is the premier input of your dair business. If you come to that realization, you just might have an opportunity to create wealth."
3 profitability drivers
One of your main goals when assuming a business-like attitude is to make sure you're meeting profitability objectives.
That means you need a good understanding of the three drivers of profitability:
- Margins — how much revenues exceed cost. Keep track of margin per hundredweight of milk, for example.
- Asset utilization — also known as asset turnover, this is the number or sales per dollar of assets you generate.
- Financing — determine your cost for borrowed money. Can you repay loans and other debts based on your profit margin, market volatility and interest rates?
You can be profitable according to your tax return or according to your income statement, but unless you're generating enough income and revenue to reward yourself for the resource contributions that you are making to the business, you may not have created value, says Mike Boehlje, agricultural economist at Purdue University.
"You've got to get paid for your time; you've got to get paid for your intellectual and managerial capacity, and you've got to get paid for your money, as well," he says. "And it's only after you take those expenses into account that you have really figured out whether you have created value."
Information management insight
So, how do you acquire the best information possible to gain the knowledge needed to move your business forward?
According to Brad Hilty, Penn State Dairy Alliance information management specialist, acquiring information involves a six-step process which includes data collection, organization, processing, integration, reporting and utilization.
Each of these steps builds upon the previous ones to advance the transformation of data to information. If the system is compromised at any level, the information obtained is useless.


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Cincinnati Reds lefthander Aroldis Chapman will remain in his closer role this season, the team's website reports.
Following a report by The Cincinnati Enquirer on Thursday that the team soon would make that news official, Reds manager Dusty Baker and general manager Walt Jocketty both publicly denied that a decision about Chapman's role had been made.
Now it has.
"It was like last year," general manager Walt Jocketty told The Cincinnati Enquirer. "It was what gave us the best opportunity to win as an organization this year. The rotation as it was, we had four guys who pitched 200 innings. We have another guy who is capable of pitching 200 innings. That's a very strong rotation."
Chapman, signed to a six-year, $30.25 million contract before the 2010 season, was given a trial run as a starter this spring after making all 137 of his major league appearances as a reliever.
WITRADO: Reds err by keeping Chapman as closer
In his first season as closer last season, Chapman had a 1.51 ERA, saved 38 games and struck out 122 batters in 71 2/3 innings.
With Chapman staying in the bullpen, righthander Mike Leake will remain the team's fifth starter and reliever Jonathan Broxton will shift to a setup role. Broxton signed a three-year, $21 million contract this past offseason, presumably to serve as closer.