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A scene from Peter Emanuel Goldman's Echoes of Silence; click here, or on the image above, to see an excerpt from the film.
I have a new essay, "On The Value of 'Worthless' Endeavor," in the latest issue of College Hill Review.
Here are the opening paragraphs: "In the 1960s, working in New York, I was part of a group of filmmakers who created films out of almost nothing at all; outdated raw stock, ancient cameras that barely functioned, often borrowed for a few days from someone else, a few lights, the barest outline of a script, and "financing" that consisted of donated labor both in front of and behind the camera. Nobody had any money; we lived in cheap apartments that cost as little as $100 a month, worked a variety of odd jobs to keep the wolf from the door, and plowed nearly everything we made back into films; films that had no market, no commercial value, and were so resolutely personal that it seemed that no one, outside of a small circle of friends, could ever possibly find them of value, worth or interest.
Sync-sound filmmaking equipment, only recently invented at that point, was beyond our financial range; so, like the early silent filmmakers, we were forced back to the primacy of the image, and we created films of deeply romantic intent using a few costumes, borrowed props, and the barest of sets. Another defining characteristic of these films was their calculated sloppiness, since we were dealing with second-, third- and fourth-rate equipment and film that was often of deeply uncertain origin; even then, it was all we could afford. So we would use every possible frame of what we shot, down to the last bit of leader streaked material at the end of the roll, in a desperate attempt to capture every last bit of our vision on film."


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Cigars Ease the Tension for the Big Dogs on Chicago's Futures Exchanges
(continued from page 4)
A few doors down from the Board of Trade (CBOT), Tom Baldwin has his eyes glued to the screen of a video monitor that keeps track of T-bond prices. "The market's crashing," he says at 9 a.m. as small rectangles of cathode-ray green flash at him, indicating that the market is making a big move. "It's dropped a point and a half in a minute. That's a lot. That would be the equivalent of the Dow dropping a hundred points in five minutes. That would be huge. A million dollars. [Greenspan] must have been very bearish," Baldwin adds, not knowing or much caring what the Fed chairman specifically said. Baldwin, like most pit traders, really cares only how the market is moving. "Wow. It's going straight down."
Lucien Thomas Baldwin III, who goes by the acronym "BAL" that he wears on the badge pinned to his purple trading jacket, occupies the top rung on the volatile, high-stress ladder of trading in the Treasury-bond pit of the CBOT. He became the biggest in the world by withstanding the slings and arrows of outrageous fortunes being made or lost in seconds. Not that there is an official ranking of this kind of thing, but Baldwin's exposure on any given day is in the neighborhood of $5 million. Fellow traders call Baldwin "The King."
"Right now, I don't have a position [in the market]. I'm sort of glad I'm not there," Baldwin says, unconvincingly for a man who started with $20,000 in 1982 and has been known to trade as many as 60,000 contracts a day with a total face value of $6 billion. "When there's a big move like this where it just goes one way for a long run, somewhere in there you're gonna be on the other side of the order, but if it keeps going like this, you lose money."
Baldwin knows all this from personal experience. "I've made $2 million in a day, but I've lost $5 million in a day," Baldwin says. Five million dollars. Lost. One day.
On March 17, 1989, Baldwin, at the age of 41, started trading early. Here's how the Chicago Tribune later reported what happened:
The time: early morning, about 7:25 a.m. Within minutes, the government will release the latest producer price index figures, statistics that can send bond prices rollicking. Baldwin is bullish and has been buying T-bonds since the market opened at 7:20, believing bond prices are about to soar. The news hits. Nearly 500 bond traders and brokers erupt in a maelstrom of shouting and waving. Buying and selling. By now Baldwin has purchased a whopping 6,000 T-bond contracts. His market position is the equivalent of the annual budget of a Third World country. He controls a staggering $600 million worth of T-bonds. The market turns. And tanks. And keeps on tanking. Baldwin has guessed incorrectly. He furiously begins to reverse himself, closing out his positions. One after another. All 6,000 of them. By 7:45 it is over. The dust settles. Baldwin studies his trading card. He has lost $5 million without blinking.
Now worth "multimillions"--true to trader form, he won't tell how much money he has--Baldwin is able to look back at that day with little emotion. "The market went down, straight down for two points and there was no out. It was instantaneous and never came back," Baldwin now explains quite matter-of-factly, adding that most people view what he does as gambling. "Then you start over." Or you smoke a cigar.
"One afternoon Tom comes into the back office," recalls Joe Howe, the owner of Jack Schwartz Importers, a cigar store across the street from the CBOT. "He's kinda quiet and sits down here and lights a cigar and we're talking a little. He asks me if he can use the phone to check on his trades. He calls and then sits down again and says, 'Well, when I came in I was down $800,000. Now I'm down only $200,000.' This was in about five minutes."
Fortunately for the traders who live and die by these riotous changes in fortune, the area around the three big futures exchanges that trade in Chicago has spawned a mini-industry that invites traders to relieve their stress. In the CBOT is Rubovits, a cigar store. Across the street from the CBOT is the Mercy Hospital Stress Analysis Program. But Jack Schwartz, next door to that, is the preferred sanctuary for many of the traders. Part of the reason is the interminable lighthearted abuse to which every customer is treated upon entering. The shop also boasts the "coldest [soda] pop in town" and free matches. But probably the biggest thing the smoke shop has to offer traders is a level of understanding that comes from having been there.
The manager of Jack Schwartz is Billy O'Hara. For 17 years, O'Hara, now 41, traded on the Chicago Board of Options Exchange. He left about two years ago and began working at the cigar store, a move that allowed him to stay close to his friends.
"I tripped over the trading business when I was 20 years old and was involved with it for about 19 years working for a brokerage house and trading for myself and learning the business," O'Hara says as he explains why he got out. "It's riskier today than it's ever been. If I'm 28 years old and I lose all my money, it's not gonna change my life at all. You know, I'm still eating pizza five nights a week. I don't have kids at 28! At 40 years old I have responsibilities and just don't want to take that risk anymore of waking up one day being a couple of hundred thousand dollars poorer [when you haven't taken] what you think is a lot of risk. And it happens," insists O'Hara, whose biggest loss was $80,000. "I saw people who lost all their money when they were 50 years old." O'Hara, who has three young children, adds, "You know, to just have a kid in college, I don't know if I could say to him, 'You have to come home. I just don't have the money to do it anymore.'"
On a day like that Wednesday in February, the traders appreciate the way they're treated. One walks by the store, looks in and shakes his head. He doesn't want to talk about it. On bad days, traders might get a Coke or a new cigar on the house.
"When it's a bad day, our job is to feel it and know we can't cross that line that you normally can cross with a person," O'Hara says. "We would never make fun of the day they had. We want them to come in the back room and we've had people come in here that just need to sit. 'Come on back here and we'll close the door.' We had a guy in here who worked across the street for 45 years as a member and he came back here and broke down. And the phones are ringing and he's crying and we're crying for him. You should have seen the place. It was like an encounter session. What's important now is this guy, because he's a friend of ours. Just got to the time where he decided he's had enough. He couldn't make it home so he came here."
Don't misunderstand, O'Hara says, things are not always so sad.
"What we like to provide is a friendship and a haven for people to come in and celebrate with us," O'Hara says. "I would say we sell more cigars for celebrating than we do on a bad day. [The traders] will just keep on walking on a bad day. They're down, they're sulking, and we understand that and we still say 'Hi' to them when they go by, but we won't make fun of them."
In his short career, Tom Baldwin has not given many people much cause to make fun of him. He has turned the profits from the pit into something of a conglomerate, even though he became a trader to avoid corporate life. In 1989, the Baldwin Development Co., along with ING Bank of the Netherlands and Chevron Oil Co., bought the historic Rookery building, built in 1888, on LaSalle Street, and renovated it. Baldwin Asset Management Co. manages the Rookery and other properties. MC Baldwin Financial operates managed futures funds. Baldwin has his own jet, which he uses mainly to get to and from his country house on Michigan's Upper Peninsula. He spent 70 days there last year.
The 50-room house, along with 19 other buildings, oversees 3.5 miles of lakefront along the shores of Lake Superior on 5,000 acres of wildlife sanctuary. The whole complex is a national landmark. Oh yeah, the house is made out of logs and has a price tag of $12 million. The first owner of the house was a successful American who came up with such quaint notions as branch banking and who helped create a little enterprise called General Motors. Buying the house led to Baldwin being the "other" bidder for the JFK humidor in last year's Jacqueline Kennedy Onassis auction at Sotheby's.
"The house was built in 1919 by a guy named Lewis Kauffman. I have his humidor from that era, so I really like humidors and I really was a fan of John F. Kennedy," says Baldwin, who bid in the auction from Chicago with the express intent of buying the humidor, a gift from comedian Milton Berle for JFK's inauguration. "So I kind of went with [the attitude] 'I didn't care what it cost.' I kinda, sort of thought it would cost about $150,000 because I'd heard Milton Berle was going to pay up to a hundred. So I thought, 'Well, screw him. If he thinks he's gonna buy it for a hundred, he's gonna have to pay a whole lot higher than that,'" Baldwin says with a laugh. He only told Joe Howe that he was going to bid six figures for the JFK humidor. Neither Howe nor Baldwin thought anyone else would bid that high. Of course, Marvin Shanken, the publisher of Cigar Aficionado, bid higher, and higher, and higher. Baldwin shakes his head. "And, you know, $510,000 is where I dropped out. So I was disappointed."
Howe calculates he could have saved one of the two final bidders a significant amount of money. "I'm pretty sure I'm the only one who knew that Tom was going to bid for the humidor," Howe says while tasting five different cigars downstairs at Chicago's Havana Café Cubano. "If I had known that Marvin was going to go that high, I would have put together a conference call with Tom to work out a compromise and maybe they would have given me a commission."
Baldwin began smoking cigars more than two decades ago, after getting his MBA in agribusiness from Santa Clara University. "I used to work in a meat-packing plant, and the general manager and I used to smoke cigars together," Baldwin remembers. "So back then is when I actually started smoking cigars. Usually the biggest one I could find."
Though he wasn't smoking drugstore cigars back then, his taste has improved since. "I don't really smoke the same ones," Baldwin says. "Gloria Cubanas, Davidoffs. I started out smoking Pleiades, then Davidoffs and then Gloria Cubanas and then Cuban cigars, sort of the current fad." The cigars are stored in one of four humidors, one of which, an old Dunhill box full of Cuban La Gloria Cubana Medaille d'Or No. 2s, sits on the credenza in his office.
By 10:30 a.m. on the day of the Greenspan comments, Baldwin has left his office and is in the pit. He just couldn't stay away from the action. Everyone else knows he is there, too. In his chosen field, Tom Baldwin is so successful that other traders honored Baldwin with the creation of a hand signal at the CBOT. The Wall Street Journal described the move as "clerks...furiously brushing their hair back with one hand--pit pantomime for 'bald.' " Baldwin loves it, the trading in particular. The signal comes in handy when Baldwin is trading and others want to follow his moves. "Shadow trading" is what such a maneuver is called.
"Here we go, Baldwin!" shouts trader Steve Horowich.
"Baldwin's a big buyer at 18," interprets Paul Johnson, a broker, after flashing a series of hand signals with Horowich. "I think he bought a thousand." That's 1,000 contracts. At $100,000 per contract, that's $100 million.
Baldwin's presence brings new fervor to the pit. He appears to be picking his spots and many of the traders seem to be looking at him. Baldwin's arms go up, tilted slightly forward, hands cupped downward, inviting others to trade. Suddenly, he spots an opportunity. Baldwin's arms flail, fingers gyrating while signaling, and then the right hand jabs forward with the forefinger pointing across the pit to the trader with whom he has just done the deal. Baldwin quickly records the transaction on a trading card and, without turning, reaches over his right shoulder and hands the card to a clerk. He is calm, his eyes already scanning the pit for the next, um, victim.
While Baldwin is scanning, Jerry Zawaski, a veteran trader, stands outside the pit. He is talking to different people, trying to gauge what's going on. Zawaski is well known to friends around the CBOT as "Zee-Wa," from his badge with the legend "ZWA." The system of using these acronyms--never more than three letters--is vital to tracking the split-second trades Zawaski makes with up to 600 other traders in the T-bond pit. The acronyms, the loud, colorful jackets and the seemingly chaotic process of using hand signals to indicate how many of what commodity a trader wants to buy or sell are all part of what the exchanges call the "open outcry" system.
Standing above the new $182 million, 60,000-square-foot trading floor of the CBOT, the open outcry system looks like a hallucination of oversized peanut M&Ms all fighting to get inside already too-crowded bowls. ZWA has not started trading yet, and some days he simply won't.
Jerry Zawaski was raised in a large family without much money on Chicago's South Side. Now he uses two-dollar bills with his signature on them as a calling card. He tells people the deuce will bring them luck. At 45 years old, Zawaski has more money than he ever thought he would.
"I'm rich," Zawaski says in about as precise a response as he cares to give with respect to where 16 years as a full-time trader of U.S. Treasury bonds has put him and his family on America's socioeconomic ladder. "You never talk about the money and how much is made," Zawaski explains about the trading culture, while on the last throes of a Davidoff Aniversario and driving what he calls his "big-ass black Mercedes," glove compartment stocked with "power snacks" optional. "If someone tells you how much they make, just cut it in half," he adds. "The kitchen in my house," Zawaski will admit somewhat incredulously, "is bigger than the bedroom I shared with five brothers when I was growing up."
The custom-built 6,400-square-foot home on the North Shore is where Zawaski heads after every working day in the trading pit at the Chicago Board of Trade--after taking a few detours.
"Hi, guys," Zawaski says to the attendants as he pulls into the parking lot of Sportsman's Park, a racetrack about 20 minutes away from the Board of Trade. Zawaski knows them by name. He visits the track about twice a week after a couple of hours on the trading floor.
"I go have lunch and then I usually try to be home by 3:30 every day," he says. "That's when the kids come home from school. It's a great lifestyle." Still, Zawaski says that Karen, his wife of 10 years, expects more of his time at home. "We have fights about it sometimes," he admits.
"My neighborhood in Wilmette is right near Northwestern [University]. Our neighborhood is populated with all these MBAs from Northwestern. They leave at six in the morning and come home at six at night," Zawaski says, building up to the argument he uses with his wife. "I go, 'Hey, you want me to go get a job where I'm going 12 hours a day and then hit the couch because I'm so exhausted?' That's my retort, which isn't too much. It doesn't fly." He laughs.
The trade-off (isn't there always a trade-off?) for the big cars, the million-dollar-plus net worth and being able to see the kids grow up is stress. We're not talking about "I'm-an-hour-late-for-the-big-meeting" kind of stress. What Zawaski and his colleagues go through every day is the kind of stress that comes from putting everything you own and have worked for on the line. If you win, you get the big house in Wilmette, you play 50 rounds of golf every summer, and you take vacations at the Ocean Club on Paradise Island where you bet an average of $576 on each hand of black-jack and see Kevin Costner having breakfast with Sean Connery. If you lose, you are out what most people would consider a year's salary. Or worse.
"For every winner there's a loser. All these clichés work. But down there they're not clichés," Zawaski says about the trading pits, adding that fear is a constant on each of Chicago's three exchanges. "I saw one guy about a year ago, froze on some order. Lost about a million dollars. A million bucks, just like that." He snaps his fingers. "He froze. He froze for an hour. Once he missed [the trade] he realized, 'I'm in shit. I'm in trouble.'"
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Study of Adefovir Dipivoxil for Korean Patients With Chronic Hepatitis B(CHB) Who Have Completed ADF 103814
- Full Text View
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- Study Results
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|Hepatitis B, Chronic Chronic Hepatitis B
|Drug: adefovir dipivoxil 10mg
|Phase 4
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase IV, Open Label, Single Arm, Multicenter, Extension Study of Adefovir Dipivoxil for Korean Patients With Chronic Hepatitis B(CHB) Who Have Completed ADF 103814
- Hepatitis B Virus (HBV) DNA (log10 Copies/mL) Change From Baseline at Week 156 of Adefovir Therapy [ Time Frame: Baseline, Week 156 ]HBV DNA was tested with Roche Cobas Amplicor HBV monitor test, Lower Limit of Detection 300 copies/mL) after 3 years (156 weeks: Weeks 1-52 in Study ADF103814; Weeks 53-156 in Study 108005) of adefovir therapy). Change from baseline was calculated as the Week 156 value minus the Baseline value. Baseline is defined as the first day of study ADF103814, of which Study 108005 is an extension.
- Number of Participants Achieving ALT Normalization at Week 104 & 156 [ Time Frame: Week 104, Week 156 ]Alanine aminotransferase (ALT) normalization is defined as a value <= upper limit of normal (ULN) range based on the set of subjects with ALT>ULN at baseline. The normal range for ALT is 0-40 Units/Liter.
- Number of Participants Achieving Virological Response at Week 104 & 156 [ Time Frame: Week 104, Week 156 ]Virological response is defined as HBV DNA level<300 copies/ml
- HBV DNA Levels at Each Collection Time Point From Baseline Through Week 156 [ Time Frame: Baseline, Weeks 68, 80, 92, 104, 120, 132, 144, 156 ]Serum HBV DNA. Baseline is defined as the first day of study ADF103814, of which Study 108005 is an extension.
- Number of Participants With HBeAg Loss, HBeAg Seroconversion, HBsAg Loss and HBsAg Seroconversion at Week 104 & 156 [ Time Frame: Week 104 and 156 ]Hepatitis B e antigen (HBeAg) loss, HBeAg seroconversion (defined as HBeAg negative and hepatitis B e antibody [HBeAb] positive), hepatitis B surface antigen (HBsAg) loss and HBsAg seroconversion (defined as HBsAg negative and hepatitis B surface antibody [HBsAb] positive). HBeAg and HBsAg seroconversion are defined as the loss (becoming negative) of HBeAg and the concurrent appearance of antibodies against HBeAg and the loss of HBsAg and the concurrent appearance of antibodies against HBsAg, respectively.
- Safety Assessment: Number of Participants With a Serious Adverse Event and an Adverse Event [ Time Frame: Treatment Phase (Weeks 53-156) ]The number of participants with a serious adverse event and an adverse event is reported. Refer to the adverse event section for details.
|Study Start Date:
|July 2006
|Study Completion Date:
|April 2008
|Primary Completion Date:
|April 2008 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Subject has completed ADF103814 and continues with adefovir dipivoxil treatment via prescription without interruption prior enrolment in this extension study.
Availability and willingness of subject to provide written informed consent.
Exclusion Criteria:
Use of immunosuppressive therapy requiring use of more than 5mg of prednisolone(or equivalent) per day, immunomodulatory therapy (including interferon or thymosin) or systemic cytotoxic agents during the study.
Previous or current lamivudine or antiviral therapy Clinical signs of decompensated liver disease as indicated by the protocol Inadequate haematological function defined by the protocol - Documented evidence of active liver disease due to other causes Hepatocellular carcinoma as evidenced by the protocol Any serious or active medical or psychiatric illnesses other than hepatitis B which, in the opinion of the investigator, would interfere with patient treatment, assessment or compliance with the protocol. This would include any uncontrolled clinically significant renal, cardiac, pulmonary, vascular, neurogenic, digestive, metabolic (diabetes, thyroid disorders, adrenal disease), immunodeficiency disorders or cancer.
Active alcohol or drug abuse or history of alcohol or drug abuse considered by the investigator to be sufficient to hinder compliance with treatment, participation in the study or interpretation of results.
Planned for liver transplantation Therapy with nephrotoxic drugs or competitors of renal excretion can be expected during the course of the study.
History of hypersensitivity to nucleoside and/or nucleotide analogues. Inability to comply with study requirements as determined by the study investigator.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00403585
|Korea, Republic of
|GSK Investigational Site
|Seoul, Korea, Republic of, 137-701
|Study Director:
|GSK Clinical Trials, M.D., Ph.D
|ClinicalTrials.gov Identifier:
|NCT00403585 History of Changes
|Other Study ID Numbers:
update with ADF103814
|Study First Received:
|November 23, 2006
|Results First Received:
|April 24, 2009
|Last Updated:
|November 24, 2010
Keywords provided by GlaxoSmithKline:
Adefovir Dipivoxil(Hepsera)
Chronic Hepatitis B (CHB)
Additional relevant MeSH terms:
Hepatitis A
Hepatitis, Chronic
Hepatitis B
Hepatitis B, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Hepadnaviridae Infections
DNA Virus Infections
Adefovir dipivoxil
Antiviral Agents
Anti-Infective Agents
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
ClinicalTrials.gov processed this record on September 20, 2017


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Clinical and Genetic Studies of VACTERL Association
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- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study will explore the medical problems in patients with VACTERL association and identify gene changes that might be responsible for them. VACTERL association can affect many parts of the body, including the bones of the spine, the heart, the lower intestinal tract, the connection between the trachea and esophagus, the kidneys and the arms. Information from this study may lead to a better understanding of the disease and improved treatment and genetic counseling.
Patients with VACTERL association and their parents and siblings may be eligible for this study.
Patients are admitted to the NIH Clinical Center for evaluation over 3 to 4 days that may include the following procedures:
- Physical examination, medical history, electrocardiogram (EKG), blood and urine tests
- Eye examination
- Imaging studies (echocardiogram, x-rays and ultrasound tests)
- Other specialized tests or consultations as indicated
- Optional medical photographs of the face and other body parts that may be involved in VACTERL association for publication in scientific texts or for teaching purposes
- Optional return visit after 2 years for repeat testing and to look for changes over time
Parents of patients have the following procedures:
- Physical examination, medical history, blood tests and x-rays, if needed
- Specialty consultations as indicated
- Optional medical photographs of the face and other body parts that may be involved in VACTERL association for publication in scientific texts or for teaching purposes
- Questionnaires about their child s medical history, growth, behavior and development, therapy and medication
Siblings of patients have the following procedures:
- Physical examination, medical history and blood tests
|Congenital Abnormalities Birth Defects Congenital Defects
|Study Type:
|Study Design:
|Time Perspective: Other
|Official Title:
|Clinical and Genetic Studies of VACTERL Association
|Study Start Date:
|September 29, 2008
|Estimated Study Completion Date:
|June 29, 2017
|Ages Eligible for Study:
|up to 100 Years (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
(A) For affected individuals, determination of clinical criteria for inclusion will be determined by prior medical record review before participation. Inclusion criteria may be met in 1 of 3 ways:
- At least 3 features of VACTERL association in an index case OR
- Two features of VACTERL association in an index case plus at least 1 feature of VACTERL association in a relative OR
- At least 2 features of VACTERL association in an index case plus at least 1 other anomaly.
(B) First degree relatives (parents and/or siblings of affected individuals) of patients with VACTERL association are also eligible to participate in portions of the protocol even if they have no features of VACTERL association.
- Anyone unwilling to provide informed consent (for themselves as adults, or on behalf of their children as minors, or on behalf of an adult who is unable to provide consent for themselves) or assent.
- Cases that are clearly not in the spectrum of VACTERL association or related to our direct research interests (e.g. referred VACTERL cases that are felt to be related to other syndromes, such as Feingold syndrome, Townes-Brocks syndrome, or Pallister-Hall syndrome, would not be included). In such instances, we would attempt to make referrals to a more appropriate investigator.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00766571
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Maximilian Muenke, M.D.
|National Human Genome Research Institute (NHGRI)
|Responsible Party:
|National Human Genome Research Institute (NHGRI)
|ClinicalTrials.gov Identifier:
|NCT00766571 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 3, 2008
|Last Updated:
|June 30, 2017
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Human Genome Research Institute (NHGRI) ):
VACTERL Association
VATER Association
Multiple Congenital Anomalies
Congenital Defects
Birth Defects
Congenital Abnormalities
Additional relevant MeSH terms:
Congenital Abnormalities
Heart Defects, Congenital
Limb Deformities, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Musculoskeletal Abnormalities
Musculoskeletal Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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SHEPHERDSVILLE - With a record turnout expected, election officials are preparing for the largest day at the polls in Bullitt County history.
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This game was classified by the community with the following category scores - Violence=0/3, Sex=0/3, Mature Content=0/3. This is a classic seek and find word search game, with more than a 10.000 words to create a random game with dimensions 10x10 to 20x20 and 10 types of letters, you never play the same game twice.
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Watch Primetime, It Won't Stop & More New Videos [Newtube]
Don't Get "Paranoid", the NewTube "Hop Is Back" and "It Won't Stop"! You know we can "Never Surrender" to the forces that would prevent us from bringing you the hottest music videos of the week on demand and in "Primetime"! New visuals from Sevyn Streeter, DJ Khaled, Janelle Monae, Hopsin & Ty Dolla inside.


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Sonorasaurus is another DJ App. There's going to be a lot of them and the idea really makes sense on the iPad. It should be interesting to see how long it's going to take before they are common place in clubs. This one is getting good reviews. You can grab it here for $12.99: click here (iTunes link)
"Two standalone decks each with a dedicated effects module offering reverb, flange, distortion, tremelo, echo and high pass. Beat-highlighted waveforms to further fascilitate beatmatching. BPM Tapper for easy BPM calculation. Pitch controls for adjusting the playback speed of your tunes and a dynamic jog area for getting your beatmatching just right . A crossfader and volume controls for mixing your songs together to any degree you choose. EQs and Gains for fine tuning the volume, low, mid and high frequency ranges. Split audio mode for headphone cueing (requires a Y adapter). A built in HTTP upload interface for adding songs to your mixing library." – sonorasaurus.com
For more info: sonorasaurus.com


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Long Term Open Label Study in Narcolepsy With BF2.649 (Pitolisant) (HARMONYIII)
This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: June 21, 2011
Last updated: January 30, 2017
Last verified: January 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
This is a multicentric International Phase III,Long term open label study(12 months)assessing the long-term safety and efficacy of BF2.649 (Pitolisant)in the treatment of Excessive Daytime Sleepiness (EDS) in narcoleptic patients with or without cataplexy.
|Narcolepsy Cataplexy
|Drug: BF2.649
|Phase 3
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|An Open-label Naturalistic Pragmatic Study to Assess the Long Term Safety of BF2.649 (Pitolisant) in the Treatment of Excessive Daytime Sleepiness (EDS) in Narcolepsy (12 Months Follow-up, Followed by a Prolonged Follow up)
Resource links provided by NLM:
Genetics Home Reference related topics: narcolepsyU.S. FDA Resources
Further study details as provided by Bioprojet:
Primary Outcome Measures:
- Incidence of Treatment Emergent Adverse Event (TEAE) [ Time Frame: 12 months ]Number of Treatment Emergent Adverse Event (TEAE)
Secondary Outcome Measures:
- efficacy on EDS as measured by ESS ( Epworth Sleepiness Scale) [ Time Frame: 12 months ]change from baseline of the score of Epworth Sleepiness Scale score (ESS) and calculation of the rate of responders defined as a reduction of 3 points of the ESS score from baseline or the normalization of the ESS score at 10 or below
|Study Start Date:
|May 2011
|Study Completion Date:
|September 2016
|Primary Completion Date:
|October 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: BF2.649
Drug: BF2.649
5,10,20,or 40 mg per day, in a once daily scheme
Other Name: Pitolisant
Detailed Description:
In narcoleptic patients, results obtained in the previous studies showed that BF2.649 reduced significantly the diurnal somnolence compared to placebo confirming its wakening effect against EDS and demonstrating its anti-cataplectic effect when administrated on an individual titration scheme established on basis of individual benefit/tolerance ratio.This long-term safety pragmatic study will provide information about long-term treatment of BF2.649, and also allow patients who satisfy of BF2.649 treatment in previous or on-going studies of Bioprojet continuing to benefit this product.This is an open-label, naturalistic pragmatic, prospective longitudinal uncontrolled, multi-centre international trial assessing the safety and effect of long-term therapy of BF2.649 in treatment of excessive daytime sleepiness in narcolepsy, on 12-month follow-up.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Males or females, aged 18 years old and over.
- Patients with a diagnosis of narcolepsy according to the International Classification of Sleep Disorders (ICSD-2) criteria.
- Patients should have complained of EDS with an ESS score at least 12 (historical assessment).
- Patients having previously participated in and completed a Bioprojet narcolepsy study assessing BF2.649 efficacy (P05-03, P06-06, P07-03 HARMONY I or P07-07 HARMONY II, P09-15 HARMONY I bis) or narcoleptic patients complaining with EDS which in the opinion of the investigator would not be able to participate in a double blind study against placebo but who could benefit from testing a new therapy such as the BF2.649 in an open label study.
or patient receiving BF2.649(Pitolisant) under condition of"ATU nominative" according to the French law (called named temporary authorization of use approved by the Afssaps) for Excessive Daytime Sleepiness associated with narcolepsy.
Exclusion Criteria:
- Patients who have discontinued study treatment during the previous studies due to adverse events related to BF2.649.
- Patients with an untreated sleep apnoea syndrome or who have any other cause of daytime sleepiness
- Patients working in an occupation requiring variable shift work or routine night shifts.
- Psychiatric and neurological disorders, other than narcolepsy/cataplexy, or other problem that in the investigator's opinion would preclude the patient's participation and completion of this trial or comprise reliable representation of subjective symptoms.
- Current or recent (within one year) history of a substance abuse or dependence disorder including alcohol abuse as defined in DSM-IV.
- Other active clinically significant illness, including unstable cardiovascular, or neoplasic pathology which could interfere with the study conduct or counter-indicate the study treatments or place the patient at risk during the trial or compromise the study participation.
- Known history of long QTc syndrome, syncope or arrhythmia or any significant serious abnormality of the ECG (e.g. recent myocardial infarction), or QTc interval strictly higher than 450 ms (electrocardiogram Bazett's corrected QT interval
- Severe Hepatic Impairment or with Severe Renal Impairment, or with any other significant abnormality in the physical examination or clinical laboratory results.
- Known hypersensitivity to the tested treatment including active substance and excipients.
- Participation in an other study - in the 30 days prior to the entry in this study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01399606
Please refer to this study by its ClinicalTrials.gov identifier: NCT01399606
|CHU Montpellier
|Montpellier, France, 34000
Sponsors and Collaborators
|Study Director:
|Kati Gutierrez, PharmD
More Information
Keywords provided by Bioprojet:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01399606 History of Changes
|Other Study ID Numbers:
2010-023804-28 ( EudraCT Number )
|Study First Received:
|June 21, 2011
|Last Updated:
|January 30, 2017
Keywords provided by Bioprojet:
Excessive Daytime Sleepiness (EDS)
Additional relevant MeSH terms:
Disorders of Excessive Somnolence
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases
Mental Disorders
ClinicalTrials.gov processed this record on September 21, 2017


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The training was held at the Sheffield offices of Slater & Gordon Lawyers, the sponsors of the Road Justice campaign. Slater & Gordon operate CTC's legal advice phoneline [2]. The Slater & Gordon Road Traffic Incident team attended the first half of the day's training and were on hand to answer any legal questions.
Information about the goals of the campaign and why this campaign is so desperately needed was given in a presentation by Rhia Weston, the Road Justice coordinator.
Training content
An important element of the local campaigner's role is to attend court hearings of drivers who have injured or killed cyclists, to report back to CTC on the outcome of these hearings, and to notify journalists of upcoming hearings. Campaigners were instructed on court etiquette, on how to gather information on impending court cases and were given advice on writing effective press releases for journalists.
Road Justice campaigners who have attended court hearings in the past have been interviewed for local television and radio to speak of the campaign's goals and their response to court outcomes. Campaigners learnt tips for being interviewed for television and radio and had the opportunity to put those tips into practice by doing pre-recorded interviews.
The training was given by Etholle George, a TV presenter with the BBC in the Eastern Region who has over 20 years' experience of working in media and Steve Feeney, who is a professional cameraman with considerable TV experience. Advice on being interviewed for radio was given by CTC's press officer, Laura Raymond, who worked as a journalist and news reader in local radio for 20 years prior to joining CTC.
The CTC training day lucidly explained the aims and strategy of the Road Justice campaign. It then put us in the hands of legal and media professionals who trained us in a friendly, non-threatening and supportive atmosphere in how best to get our message across and build support for our demands. Thanks for a very professionally organised, informative, inspiring and confidence-building training day."
Julia Podziewska, Road Justice local campaigner
The role of local campaigners
The role of the Road Justice local campaigner is to:
- Liaise with local representatives of the police, prosecution services and courts;
- Raise local road safety concerns with decision makers and local media;
- Raise the campaign profile by engaging with local media;
- Track local stories of injustice;
- Attend court cases of drivers who have injured and killed cyclists.
To become a Road Justice local campaigner, please fill out this short form [3].
The Road Justice campaign
The aim of the campaign is to make the roads safer for cyclists and all other road users by making the justice system take a tougher approach to bad driving. The campaign is urging the police to combat bad driving by enforcing road traffic law and thoroughly investigating all collisions resulting in serious injury and death. Currently, there is a petition running on the campaign website calling for improvements to roads policing. Please add your name [4] to the petition, if you haven't already done so.
The campaign also wants the police and prosecution services to make charging and prosecution decisions appropriate to the severity of an offence and, in particular, not to downgrade 'dangerous driving' to 'careless driving'. We want the judiciary to use their power to impose tougher sentences for driving offences and to favour long-term driving bans. The campaign also wants the whole of the justice system to provide victims of road crashes and bereaved families with adequate support and information. Visit the Road Justice website [5] to find out more.


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Amanda Bynes is back. And she may be of the undead.
The troubled actress was spotted about 1:45 a.m. Friday morning, alone, at New York hotspot SL, sources told E! News.
"She was alone, definitely like ... walking into people, she looked just zoned out of her mind and randomly dancing with some guy," said the eyewitness.
Did she chomp on him? That would explain a lot.
"We were, like, 'Can we get a picture of you? You're Amanda Bynes?'" said the source. "And she said, 'No, I'm not and I don't want my picture taken.'"
The weird part was that she said it in Romanian.
Bynes supposedly continued to walk around before leaving with some people she had just met.
Sensible. She obviously needed to feed the rest of the pack.
"We wanted to go to Avenue after SL, so we walked there," the source said. "On our walk, we saw her again with those people, just stumbling. I felt so bad for her. I've never seen anyone like that, zoned out. So we walked into Avenue and I just saw her walk into (popular hangout) Artichoke. She just sat in a booth by herself and that was the end of that."


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Just a few days ago, I realized that I needed a new fitness goal, which seems almost paradoxical to me. I weigh 320lbs and after moving to Phoenix in March, decided to start walking/sprinting so I wouldn't get murdered at E3 when I needed to haul myself between the two ends of the massive convention center.
I used to work retail and when my car broke down, I would walk 20 miles a day in the Colorado heat. After that, I landed in a call center job and became sedentary for the next 2.5 years, wiping away all of my strength. I have never been a runner; I was always just fine with long - distance walks.
Fast forward past the call center job and I tackle E3 and don't die. I feel good about it, but I'm not in the effortless all - day walk shape I used to be. Tonight, I did a 30 minute walk and made it 1.3 miles and felt okay.
So I decided to look into marathons. I grabbed Whitsett's Non-Runner marathon training book, which is basically 5k2m with a few pages for c25k. I've been reading testimonials online and some people's couches are a bit different than mine, so it's been hard to read into training programs. People who call themselves couch potatoes can somehow run 2 miles before fatiguing. Yeah, whatever.
Anyway, this is getting long, I want to train for a marathon and get myself into the shape I've wanted to be in. The Phoenix Marathon happens on March 2, which is just over 7 months away. Could I pull it off or am I being too ambitious? I'd hate to spend the rest of the year training and then only do a half - marathon. There's no shame in that, but in the months following, running in Phoenix in any kind of sunlight becomes intolerable and I know my physical activity will slow way down.


text:
I have been maintaining a fork of wbond's Sublime Tortoise here: github.com/atwright147/sublime_tortoise
I'm not a Python dev, so I don't really understand the code. I have been pulling in pull requests and adding fixes from the issues tab.
Tortoise seems to have died again, since I updated TortoiseGit to 220.127.116.11. I there a way to get some errors out of the Sublime Tortoise package so that I can see what is going on and hopefully try to fix it (I suspect it is just a paths issue but can't even begin to figure it out until I can see some debugging data).


text:
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A CAR crashed into the side of a bungalow in Benfleet on Wednesday evening.
Police were called out to the scene in Thundersley Park Road near the junction with Bread and Cheese Hill just after 7pm after receiving reports a black Ford Fiesta had flipped upside down and careered into the derelict building.
Firefighters from Rayleigh Weir fire station were also called to the scene to help retrieve the vehicle and make the property safe with the help of a structural engineer.
At present it has not been confirmed whether anyone was injured or taken to hospital as a result of the crash.


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Topic: Worried in Wisconsin
Hi. My name is Jean and I was recently diagnosed with cc. The doctors told me I had a small hemangioma on my liver 2 years ago and there was nothing to worry about.....many people have them. A few months ago, I noticed a sight discomfort under my right rib cage. I went back to my local doctor and was told that the hemangioma had grown from 3 cm to 8 cm. They gave me 3 CT exams, an ultrasound and did not want to do a biopsy because hemangiomas are clusters of blood and they were afraid it would burst. They wanted me to have an MRI. I am very clostrophobic so I took my test results from the local hospital and went to the university hospital in Wisconsin, where I saw a liver specialist. He viewed my scans and said he would be "very surprised if it was cancer" and even thought I had some sort of parasite from Mexico.....that test came back negative, so he scheduled a CT. During the CT, the tech told me she sees cancer all day every day and that this was not cancer. I was relieved. Two weeks later I got a call that they wanted to biopsy the mass. Ok, no big deal, right? Even the biopsy doctor stated outright that he did not feel it was cancer. Well a week or so later I got the news....cancer. They told me over the phone that the mass was so huge they did not feel surgery was an option....possibly a liver transplant. I was devastated. I am 43, non smoker, occasional drinker with small kids at home and NO family history of any type of cancer!
A couple days later the lead surgeon from the transplant team at university hospital called me to tell me the team had reviewed my file and I was indeed a candidate for the surgery, which was scheduled for 3 days later. After 4 hours under the knife, the pathology report came back that the cancer was contained to the liver, with no lymphatic involvement, no vascular tissue involvement, nothing. The tumor was completely removed with a 1 cm border around it as well as 70% of my liver, which I am told should be regenerated by now (5 weeks later). I am supposed to feel "lucky" as I do not have to have chemo or radiation, just come back every 3 months for CT exams for follow up....however, I am terrified. I know nothing about this cancer or any other for that matter. I find myself very depressed and constantly wondering ....did they really get it all....how long do I have...will it come back.....etc.
In reading some of the other stories posted here , I do realize that things could be worse, but I am really scared. Has anyone else had this type of news?......


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For more than two decades, the National Wildlife Federation's Tribal Program has worked with tribes to bring wild bison back to their lands and cultures and restore this iconic American species to its rightful home on the prairies.
In November 2016, the Eastern Shoshone Tribe and the National Wildlife Federation welcomed buffalo back to the Wind River Reservation in Wyoming after an absence of over 130 years.
Our Vision - Over 1,000 buffalo on hundreds of thousands of acres on the Wind River Reservation.
Our Plan - and how you can help make it happen.
To learn more, contact the National Wildlife Federation's Tribal Program.
In 2012, the Fort Peck Tribes, the National Wildlife Federation, and conservation partners succeeded in convincing the state of Montana to transfer more than 60 bison back to tribal lands. On March 19. 2012, after more than a century away, wild bison were returned to roam the Great Plains in Montana.
In November 2014, we took another significant stride by restoring an additional 134 Yellowstone bison to the Fort Peck Reservation.
Tribal people have a deep historical, cultural, traditional, and spiritual connection to bison that stretches back thousands of years. The National Wildlife Federation and the Tribes share a common vision of establishing herds of genetically pure wild bison across the West and restoring Native Americans' cultural connection to bison. And you can help make that vision a reality.
Help National Wildlife Federation continue to protect Yellowstone's historic bison herds >>
In 1997, the National Wildlife Federation signed a memorandum of understanding with the Intertribal Bison Cooperative, the first ever conservation agreement between an environmental organization and an inter-tribal group, to advocate for the return of wild bison to Tribal lands.
The political opposition to the return of the bison seemed insurmountable, as bison were seen as a threat to domestic livestock. Overcoming these challenges is a significant conservation milestone and opens the door to moving wild bison onto other large landscapes.
By bringing bison back to these reservations, we are revitalizing a landscape, habitat, and a diversity of wildlife, while also re-establishing Native Americans' cultural and historic connections to wildlife and the land.
Watch the bison run free on tribal lands
NWF's Garrit Voggesser talks about the disappearance of bison from tribal lands
Assiniboine Cultural Leader Larry Wetsit talks about the importance of bison to tribes
Steve Torbit talks about how the return of bison could impact the ecosystem


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Twins pitcher Brad Radke may have played the last game of his 12-year career, and it was a disappointment. Throwing with a badly injured shoulder, Radke allowed five hits and four runs, three of them earned.
"I feel bad. I gave up four runs. I let the team down a little bit," said Radke. "But it just wasn't meant to be."
After the game, Radke said a comeback is unlikely, but he seemed not quite ready to call it a career.
"Who knows? I might wake up tomorrow feeling different. But we'll see," said Radke. "I'll just make a decision here soon, and we'll go from there."
Radke said he felt good on the mound, considering the jumble of ripped tissue and cracked bone that passes for a shoulder. And A's manager Ken Macha said the velocity of Radke's pitches looked normal.
Macha said the A's Milton Bradley and Eric Chavez, who blasted early home runs, just did a good job of battling Radke.
"Coming into this game, some of our hitters had some pretty good numbers against him. And Milton was one of them. Boy, that ball Milton hit really jumped out of here," said Macha. "Normally, on an overcast day like today, it doesn't fly that well. Still, he kept the team in the game. It was 4-2. So I think he pitched well enough to keep his team in the game."
Solo homers by Torii Hunter and Justin Morneau didnt help the Twins, who gave up four unearned runs in the disastrous 7th inning. Overall, Twins hitters went one-for-19 with runners in scoring position during the series, and played uncharacteristically sloppy defense.
"We picked a bad time to have some bad ballgames," said Twins Manager Ron Gardenhire. "We didn't catch the ball. We missed a lot of opportunites to drive in runs during this whole series. The Oakland A's won this series. They played good baseall. They made all the plays, they hit the ball, they came up with the big at-bats. They won this series."
Why didn't the Twins play good ball against Oakland? After all, they staged a remarkable comeback to win the Central Division on the last day -- after a slow start to the season.
"I don't know know if it was the whole thing about being in the playoffs, people not being able to play their own game or whatnot, but we just didn't play well," said shortstop Jason Bartlett. "This is probably the worst three games we played siince I got called up."
Gardenhire credited the A's with playing great ball -- much better than when these teams last met in the playoffs in 2002, when the Twins won in five games. Gardenhire said the sting of this playoff sweep will soon wear off.
"There's a lot of not-too-happy guys in the clubhouse that have worked very, very hard to get here. It's a little disappointing for us right now. But after we sit back and reflect on this thing, it's been one heck of a year for our baseball team," Gardenhire said. "Just because we had a bad series here doesn't take away from what we accomplished. It's just disappointing, because we thought we could carry this thing on a little farther."
Twins fan Cory Henrickson -- originally of St. Cloud but now living in Oakland -- waited outside the ballpark after the game, hoping for a glimpse of her favorite player, Bartlett. She carried a sign that read "Bartlett is a Hotlett." Despite a bad end to the year, she was in good spirits.
"It was sad, but it was still fun to come out and see the energy in Oakland and see the team out there," Henrickson said. "We had a good time."
Henrickson says she's crossing her fingers that the Twins will make it deeper into the post-season in 2007.


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DAWN wrote:What is the specific of Dhammakay teachings that is cryticising? Or it's not a teachings but behaviour?
If this is an offtopic, please delete it.
Dhammakaya Movement of Thailand
Basing itself on the Pali suttas and meditative experience, it teaches that the Dhammakaya is the eternal Buddha within all beings. The dhammakaya (dharmakaya) is nirvana, and nirvana is equated with the true Self (as opposed to the non-Self):
The Buddha discovered that nirvana is atta [the Self], this movement teaches.
Or it's not a teachings but behaviour?
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|Trad, 3 pitches, 200'
|YDS: 5.10- French: 6a Ewbanks: 18 UIAA: VI+ ZA: 18 British: E1 5a [details]
|J&J Urioste, B Bradley, M Ward, 7/'80
|Page Views:
|Submitted By:
|Tony B on Feb 20, 2004
|RAIN AND WET ROCK The sandstone in Red Rocks is fragile and is very easily damaged when it is wet. MORE INFO >>>
|Comments on The Gobbler
|Add Comment
|Show which comments —
Comments displayed oldest to newest — Skip Ahead to the Most Recent Dated Oct 31, 2014
By david goldstein
Mar 11, 2004
|Good variety, P2 is a nice change of pace from the typical Black Velvet slab crimping. I've done this climb twice and both times found P2's crux move desperate -- much harder than the 5.9 guidebook rating; a purple (0) Alien size piece comes in handy at this spot (just above the bolt). Also watch out for the rope getting stuck in the finger sized slot after the P2 crux -- I had to rap down from the belay to free it.
By Max Schon
Mar 16, 2004
rating: 5.10a 6a 18 VI+ 18 E1 5a
|Dito on the rope getting stuck in the groove on pitch 2. I'd been warned about it, so I managed to keep it out, but it could easily get stuck. I watched a guy have to downclimb the slot to free his rope. It didn't look bad, but still not any fun.
By JKVawter
May 30, 2004
|Rope stuck on pitch 2? Check. I belayed on the ledge at the base of the 5.9 face, cutting pitch 2 in half, and lowered/downclimbed to free the rope. We continued up pitch 4 of DWT: the crack. This is a rope graveyard, many strands of aging rope in the back, and we nearly lost ours. If you want to continue, best advice is not to rap the crack. Keep going (do pitch 5 of DWT) and use the rap route well left of the crack.
By Eric and Lucie
From: Boulder, CO
Oct 26, 2004
|Just climbed the route yesterday. We had done the first 2 pitches a few years ago and really enjoyed them: lots of variety! About the third pitch: I thought there is no way that pitch is 5.9. We've climbed extensively on this wall (POD twice, YBR twice, DOWT twice) and this pitch has one move which I think is at least as hard as anything on POD for example: around the next to last bolt (I think), all the positive crimps disappear and you have to do this really thin, slabby move... I'd say about 10b/c. I wonder if flakes may have broken off: there were several white patches in that section. Anybody knows?Great route in any case. Highly recommended.
By Guy H.
From: Fort Collins CO
Oct 29, 2006
I was gobbled twice on this one. I had to rap and free the rope the first time, and my partner had to ascend the rope the second time. Is there any good beta on plugging the finger crack? I was thinking a pink tricam in the crack might prevent the rope from getting stuck.
This is a fun line to finish the day. Just bring two ropes to rap from the P2 anchors.
By David Stowe
Nov 15, 2007
I had done plenty of climbing in Black Velvet over the past few years but never got around to getting on the Gobbler. I was very pleasanly supprised by the tremendous overall qualtiy of the the route and great variety that each pitch had to offer. I had heard/read that the first pitch was slick/polished and it looked it from the groud. In fact you really can't see much of the first pitch until you are actually on it. Really fun and interesting moves following the natural features on the pitch and there was nothing slick about it. There was some smearing, but after climbing most of the time in the Gunks, smearing on sandstone is a pleasure and there is plenty of friction. The second pitch offered completely different challenges with great gear. I agree that the crux was the move accross into the chimney. My fingers were also too big to fit into the corner crack below the bolt, so I resorted to pinching small features on the right arete/face to move up and into the chimney. The third pitch was fun vertical wall climbing. I thought this pitch was a little more interesting and of a little better quality than anything on Price of Darkness. Wound of climbing this pitch with a big smile as it was nothing like the runout commiting climbing that a few people had told me about. I agree that the top of the pitch was the crux and is in the 10b/c range.
this is a route I will definitely do again as it is superb and only takes a short time.
By susan peplow
From: Joshua Tree
Nov 19, 2007
rating: 5.10 6b 20 VII- 19 E2 5b
Good route to get on while waiting for the lines to clean to the left. Beware of crashing into other parties using the anchor on top of the 3rd pitch which shares with DofWT.
If you the 3rd pitch belay is occupied (extremely likely) consider clipping in a few draws and lowering down to the 2nd pitch belay using a TR scenario for your partner who can clean it when they get there. Perhaps that's a better solution than sharing the ledge with 2 or 3 other people.
1/2 can easily be linked. Crux of the route IMO is getting into the slot. Very tricky.
P3 - typical face climbing on a featured varnished face.
You can rap station to station using a single 70' rope if you prefer to not trail a line.
By John Hegyes
From: Las Vegas, NV
May 7, 2008
rating: 5.10b 6a+ 19 VII- 19 E2 5b
|The third pitch is not 5.9!
By Andy Laakmann
Site Landlord
From: Bend, OR
Oct 12, 2009
rating: 5.10- 6a 18 VI+ 18 E1 5a
|Linked Gobbler into the Yellow Brick Road and then DoWT. From the ledge atop the Gobbler (top of P3 of DoWT), we did the "reverse traverse" and built an anchor where DoWT and Yellow Brick Road diverge. Anchor was one bomber bolt, bomber small nut, and some other not-so-bomber pieces. Then the two pitches up YBR and then two pitches of DoWT. It was fun and something different, and a nice option when you want to continue up and there is a party in your way on DoWT.
By brucelacroix
From: Carson City, NV.
Jun 5, 2010
rating: 5.10a/b 6a+ 19 VI+ 19 E2 5b
|The 3rd pitch felt like 5.10 to me. Maybe some holds have broken off?
By Sherri Lewis
From: Sequim, WA
May 4, 2012
Excellent moves and rock quality on this one. After the crux move on P2, my partner short-slung a finger-size cam off to the left(in the start of the chimney) which kept her rope from feeding into the gobbler crack as she moved upward.
Also, as you start up P3, be aware that there is an .11d route which branches off to the right after the second bolt. (My topo mistakenly had a line curving to the right for Gobbler and after a move or two in that direction it was clear I was not on a .10a.) Your bolts for Gobbler go pretty much straight up from the belay and straddle a thin crack system. The bolts for the .11d off to the right are painted a darker color than the shiny Gobbler bolts.
From the top of P3, we did a single rope rap(with a 60m) to the top of P2, then a double rope rappel took us over the roof and back to our packs. No issues with stuck ropes stuck in the chimney that way.
By -robin-
Oct 21, 2012
rating: 5.10- 6a 18 VI+ 18 E1 5a
|First two pitches are great, linked with a 70m! Its an excellent long pitch if you have the rope, I quite recommend it. Off the 2 pitch anchor did 18 Year Mcallen instead, head right up the well bolted face, good pitch with a short punchy crux.
By Patrick Mulligan
Sep 13, 2013
rating: 5.10a 6a 18 VI+ 18 E1 5a
|The moves from the crack to the slot on pitch 2 are well protected, but stout.
By Arch Richardson
Oct 31, 2014
rating: 5.10b/c 6b 20 VII 20 E2 5b
Route description is a sandbag and should be updated someday. My take:
P1: Positive but continuous 10a edges after scramble to first bolt. Pendulum falls for leader possible between clips.
P2: Moderate crack leads to a 10a move into an 8+ chimney. Crux is well protected and it is possible to pull thru on gear.
P3: 10b/c smeary crux move near the top of a continuous and exciting 10a face. Well protected with bolts and cams but it is not possible to pull thru on gear. Not "5.9" and there are few "big holds".


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In my mind, the Pacers have a few pieces in place that will still be around once we're a very good team again.
I think that Rush, Granger, and Hibbert can all start for a good team. I think that Dunleavy and Jack can be primary bench players on a good team.
As we look forward, the two big holes are PG and PF. What kinds of players do we need to look for to play in those positions? That's the question that interests me. I'll take a stab at it.
PG: This is the easier of the two. It's the exact type of PG that most people on this board want: A pass-first PG who plays solid defense and doesn't turn the ball over. A guy like Jose Calderon would be a great fit. Unfortunately, very few of these PG's exist. The most important aspects are defense and low TO's. I think that Danny will continue to get better at creating for others. This is also something that seems to come pretty naturally to Rush when he's playing well. We don't need the future PG to be an extremely creative player. A mistake-free good defender with an outside shot would be sufficient. In other words, a PG version of Bruce Bowen or Shane Battier.
PF: This is a much harder question to answer. Many people on this board point to Dale Davis as the ideal PF, but is he really the right guy to play next to Roy? The PF & C relationship is important, because when it doesn't work out, it can really derail a team. Davis and Smits worked well together because Smits was very good offensively and Davis was a great rebounder and defender. Brad Miller and JO was also a tandem that worked well together.
Hibbert is an interesting player to think about pairing with someone. He does a number of things pretty well. He can operate offensively both in the low and high post. He's got a pretty decent jump shot. He does fairly well on the pick and roll. Defensively he does well against bigger, more physical offensive players, but struggles against smaller, quicker guys. It looks like he'll develop into a good shot-blocker, especially from the weak side. I don't think he'll ever be a great rebounder, and I don't see him making a lot of hustle plays. According to 82games.com, he's been more effective this year paired with Murphy than with Foster.
In thinking about a player, I think we need to get a more talented guy at PF than we do at PG. First and foremost, our PF of the future needs to be able to do two things: rebound and guard perimeter-oriented PF's. Even though Rush and Granger both rebound well for their positions, Hibbert's sub-standard rebounding will always be a problem unless we have a stud rebounder at PF. Our PF is also going to have to be able to guard guys like Rashard Lewis and Antawn Jamison. Murphy's killing us this year with his inability to guard those guys. It's forcing us to go small.
If we can find a guy who can get 10+ rebounds and guard small PF's, what else should they be able to do? I'm stumped on this a bit. I'd like this guy to be an above-average athlete who can make up for Roy's slowness. A guy who's active on the offensive boards and a good finisher would be more important than a guy having a particular offensive skill set (3-pt shooter, low-post scorer, etc.). A Dennis Rodman type would be nice.
I'd love to hear others thoughts on this. Also, if there's any players available via trade or draft that people think would fit-in nicely.


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Our intrepid team from Bob's Red Mill embarks early tomorrow morning for Scotland. We had our last state-side practice this morning and made our dish in record time. Matt is feeling pretty confident and our team is ready to get on the road (er, plane).
I'll be posting updates and photos from our trip here on our blog, on our Facebook page and on Twitter. Cheer us on and watch to see if we can bring home the Golden Spurtle one more time!
P.S. In case you missed it, check out Bob's Savory Oat Fritters to see what we're taking as our specialty dish.


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|Paige Rawl
Rawl made the best of her situation. She became the youngest certified HIV/AIDS educator through the American Red Cross and then began educating teens and adults around the country by sharing her story. She was even spotlighted by POZ in 2011 for her efforts.
She still travels nationwide talking to Americans everywhere about her story. But she is also preparing for her freshman year of college—and for her chance to be on the upcoming October cover of Seventeen.
Rawl is one of the finalists in the magazine's 2013 Pretty Amazing Contest. Seventeen is giving one of the finalists a chance to tell her story in the magazine and win a $10,000 scholarship. We asked Rawl about the contest and her goals for the future.
How have things changed in your life now that you're going to college?
I am a lot clearer about where I want to go in the future. I definitely know that speaking and educating is a key part of my life. I am experiencing life in my own way now and becoming more independent.
Why did you decide to enter the Seventeen contest?
I heard about it from a friend and then read about it. I thought I would be a good fit because I decided to take a hard situation and turn it into something good. I was encouraged by other kids and teens I mentor.
I did this for them because they keep me going and I know that me speaking out about this will educate people, rid the stigma and encourage the kids I mentor to speak out about the virus.
What would you do with the scholarship money?
I am definitely going to use this money for college and to go out there and travel and speak some more. Because I want to work in a lab in the future, I have to go to school for at least six to eight years, so this will definitely help me.
Are you ready for the potential media attention?
My story has been around in and out of the media since I was in the eighth grade. I had all through high school to get used to my story being out there in different places, so this is something I have learned to build up to.
I have actually gotten a lot of support from my friends, the people in my town and the HIV community. I think that having that support behind me has really helped me through this process.
What's the response been so far to your being a finalist?
I've gotten messages from people in the U.K., Italy, Australia, and even a message in Spanish. All have been encouraging. This is definitely helping me get my story out there.
I am also getting messages from kids in middle school, just saying they are proud of what I'm doing. I hope this shows that I can do things just as much as a normal person. I hope it shows people that you don't have to be afraid of someone with HIV.
What are your plans for the next few years?
I will be majoring in molecular biology at Ball State University [in Indiana]. I want to become an HIV/AIDS medicine researcher.
I'm really excited to start college and will be doing an academic early start, so I will be moving into my dorm on my birthday and meeting my teachers before classes start.
I also have a memoir that I am working on. I have been working on it since April 2012—it's been a very long process.
To read the 2011 POZ magazine profile on Rawl and other HIV-positive young people, click here.


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This star rating is the opinion of the property owner only. A Self-Rated hotel has not been assessed by the AA or Visit Britain, whose official star ratings we use across LateRooms.com.
Garryvoe Hotel4 Self rated
Ballycotton Bay Castlemartyr, Garryvoe, Co.Cork
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About the hotel
Garryvoe Hotel in situated in East Cork directly overlooking beautiful Ballycotton Bay and Garryvoe Strand, taking in spectacular views of 5 km of one of Ireland?s finest beaches. Garryvoe Hotel is just 30 minutes drive from Cork City and Cork International Airport, we offer the perfect location, with scenic walks, sailing, windsurfing and many local attractions close by. Our guest bedrooms are of contemporary design with dramatic sea views.
At Garryvoe Hotel, our aim is to greet guests at least twice, first when they discover us and second when they return for more. Wireless Broadband throughout the entire hotel.
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Frandsen joins Nats, excited for opportunity
PORT ST. LUCIE, Fla. -- Over the past five days, Kevin Frandsen has felt a whole range of emotions.
The veteran utility man, outrighted off the Phillies' 40-man roster on Sunday, forfeited a guaranteed $900,000 contract by opting for free agency, then signed with the Nationals on Wednesday, reportedly for the same amount, plus incentives. He joined his new teammates on Thursday for their final Grapefruit League game against the Mets.
"Ultimately, it went from shock on Sunday to sick to my stomach on Monday, then Tuesday being really confident what I was about to do," said Frandsen, who came off the bench to go 1-for-2 with a double.
Frandsen spent the past three years in the Phillies' organization and much of the past two as a versatile backup infielder and pinch-hitter with the big league club. He figures to fill the same role with the Nats. The 31-year-old can play first, second and third base, is a career .289/.343/.435 hitter against left-handed pitching and last year led the Majors with 14 pinch-hits, although his overall offensive numbers slipped.
Frandsen said he enjoyed his time with Philadelphia and that the coaching staff, especially manager Ryne Sandberg, "meant the world" to him and his family. But this was a business decision, on both ends.
"They made their decision, thought I was roster flexibility, and I didn't feel that way," he said. "I have a lot more pride in myself, I feel like."
Frandsen called it a "leap of faith" to opt for free agency but considers himself a winning big league player and thought he could get that opportunity elsewhere. Although he's barely had a chance to meet his new teammates, he's excited for what the Nats might be able to accomplish.
"I'm jealous of all my buddies in San Francisco that have two rings now," said Frandsen, who was drafted by the Giants and spent time with them from 2006-09. "I want my hands to be a little heavier."
Andrew Simon is a reporter for MLB.com. Follow him on Twitter @AndrewSimonMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Ear, Nose, and Throat Disorders
Swollen Nostril, Upper Lip and Cheek Bone
A couple days ago the area around my left nostril was a little tender and slightly swollen. I thought it was the beginning of one of those deep, painful zits that happen from time to time. The next morning I woke to find my upper lip was swollen just mainly on the left side and felt as if I had a roll of cotton shoved under my lip...the area around my notril was more painful. I couldn`t blow my nose, open my mouth to eat, or smile without it hurting. I thought I was having an allergic reaction to something, maybe even a bug/spider bite (even though I could see any redness or bite marks) and started taking some benedryll which seemed to help a little as the day went on. This morning it was 3 times worse. Upper lip was massively swollen, and the swelling had spread up my cheek bone to the bag under my left eye...my sinuses were tender (not painful, just tender). Again I took benedryll and it`s helped some. I want to know what causes this and how long it will last and how I may be able to get rid of it. I`m breathing through my nose quite well, better than normal actually for it being allergy season...there`s no mucus either, no runny nose...nothing. Normally I`m very miserable this time of year, but that`s not the case here. Could you please help me?
Thank you for visiting NetWellness. On this site, NetWellness experts try to answer general questions about health. Only a health professional performing a thorough clinical exam is able to evaluate your symptoms. However, NetWellness may have some general information available that you can access through our search feature. Feel free to write back if you still have questions or need an explanation.
NetWellness Staff


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A summer promotion offers a Disney resort vacation for four to consumers who visit the Chiquita Brands International Facebook page and enter the "Summer to Remember" sweepstakes.
Consumers can also text "ChiquitaFun" to 66937 for a chance to win the Disney vacation, which is being promoted via Chiquita Bites fruit snacks. The sweepstakes runs through June 30.
Chiquita, which just relocated its headquarters to Charlotte, N.C., has complete retail promotion kits available. The kits include point-of-sale materials and are supported by a nationwide digital advertising campaign, according to a news release from the company.
In addition to entry forms for the Disney trip, the "ChiquitaSnacking" page on Facebook offers games and downloadable Disney coloring pages.
Chiquita Bites and other Chiquita products are available at Walt Disney World Resort and theme parks as part of both companies' campaigns to encourage healthy snacking. Chiquita Bites products include apple slices and pineapple spears that are pre-washed and ready to eat.


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The Graffiti Run - The Colorful 5-K!
Sun 09/01/2013
5-K, Recreational/Fun Walk/Run
5000 Participants
Online Entry Available
|Sun 09/01/2013
|Recreational/Fun Walk/Run (5-K)
What is the Graffiti Run ? The Graffiti Run will be the most colorful day of your life. Bold statement, we know (especially if you lived through the 70?s or ever owned a hyper-color t-shirt), but just hear us out. First off, we use the term ?run? loosely here at the Graffiti Run. Our 5-K course is more about having a blast with friends and family than it is about busting out four-minute miles. So feel free to run, walk, dance, crawl, roll, piggy-back ride, or summersault your way through the color madness. Secondly, the no-six-pack-required course means the Graffiti Run is for EVERYONE (unless you hate color or smiling, then you are not invited). You will see green grand-parents next to pink college students. Yellow marathon runners alongside blue children. Orange moms next to purple unicorns*. We only have two rules: you must get absolutely drenched in color and have an amazing time. So don?t miss out on the most color filled day of your life at our next Graffiti Run!
- Name:adam lippert
- Email:
- Phone:281-550-7111
- Address:NOLA, LA
NOLA, Louisiana 70094


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A TEENAGER is to walk the Pennine Way to raise money for the Airedale Hospital Emergency Department Appeal.
Tom Crossley, 15, aims to complete the 268-mile route – linking Derbyshire and the Scottish Borders – over three weeks this summer.
He will be accompanied during different parts of the challenge by his mum, Airedale Hospital A&E consultant Dr Meg Crossley, and his grandfather John Asher.
Tom will be training with Mr Asher this Sunday (June 15), Father's Day.
Dr Crossley said: "Tom and dad have been planning to do some training walks for a while and as I'm working on Father's Day, it's a good opportunity for the two of them to go out together.
"They have been enjoying walks together since Tom was little.
"My dad and I will be going along to support Tom on part of his journey this summer."
Dr Crossley is urging others to don their walking boots in support of the appeal.
"We are asking anyone who is interested in walking to consider getting involved in fundraising for the appeal by taking part in – or organising – their own sponsored walk," she said.
Visit justgiving.com/airedalehospitalemergencydepartmentappeal to donate to the appeal.


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A GARDENER was caught with a £1,200 stash of cannabis after he and friends clubbed together to buy drugs for a festival, a court heard.
Daniel Westwell, 22, was arrested after police stopped a van on Burnley Road, Accrington and smelt cannabis.
They found a black plastic bag under the front passenger seat of the vehicle, containing bags of cannabis, weighing a total of 175 grams.
Cash totalling £500 was also discovered, but Westwell said that was money from his business.
The defendant told officers about 15 people had chipped in to buy the drug.
At Burnley Crown Court, Westwell, of Hodder Street, Accrington, admitted possessing cannabis with intent to supply on June 15.
The defendant was given a community order, with 120 hours' unpaid work and must pay a £60 victim surcharge and £200 costs.
Sentencing, Judge Ian Leeming, QC, told Westwell: "You say, and it's accepted, that you clubbed together with friends to buy some cannabis."


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Monitor, analyze, and improve data integrity with SAP Information Steward software. Combine data profiling and metadata management tools for continuous insight into the quality of enterprise information to optimize processes, and enhance operational, analytical, and data governance initiatives.
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Maximize the potential of the digital information framework with the SAP Extended Enterprise Content Management application by OpenText. Manage document and records, information retrieval, and collaboration. Connect e-mails, presentation slides, documents, and other unstructured content to core business processes.
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Mail: Southern statues symbolize suppession
Mail: Thanks for helping Aiden
More opinion
Fall: Good time to spray musk thistle in rosette stage
Robertson and Delsing re-elected chair, vice chair of NWB
More Ag News
The big spurs on the edge of the lawn of First National Bank in North Platte have a big aim -- to carry dozens of small, profound messages to the Cattlemens Ball.
The ribbon-covered "serenity spurs" will then be moved to the Cattlemens Ball at the Hanging H Ranch between Sutherland and Paxton shortly before the ball begins June 7.
The hosts of the Cattlemen's Ball are Ralph and Beverly Holzfaster of Paxton and Neal Hansen of Sutherland.
The Ball is a weekend of displays of western art and culture, games, social activities, concerts and dances, with the emphasis on beef as an integral part of a healthy diet.
The Ball also raises money for cancer research at the University of Nebraska, lots of money, netting millions of dollars for the cause. Individuals, businesses, social and civic groups all pitch in.
Tickets are $75. Plus, there are donations, raffles and auctions.
The totals are impressive. The 2011 Ball raised just shy of $1.5 million.
Since the first Ball was held in Nebraska in 1997, more than $7 million has been raised.
Artist Shannon Hansen, who has tried his hand at metal sculptures in recent years, was approached about making something that would enhance the Ball.
I was thinking about a Western theme, he said, adding that he "mostly wanted to do something monumental.
Hansen has pretty good grasp of the West. He grew up in Ogallala. He was in 4H and showed horses. He roped calves in high school rodeo.
Today, he is the welding program chairman for Southeast Community College at Milford and he creates works of art on the side, a blue-collar artist.
The son of the late Jim and Dee Hansen who owned Kingsley Lodge at Lake McConaughy and Georgie Oorlog of Lincoln, Hansen studied at Peru State College, Western Nebraska Technical College at Sidney and Southeast Community College at Milford.
He holds a bachelor of technology degree, and associate degrees in industrial welding and non-destructive testing.
He has taught college for 14 years.
The serenity spurs were sponsored by Blue Cross and Blue Shield of Nebraska and former State Sen. and Big Springs resident Jack Mills, who serves on the Blue Cross and Blue Shield board of directors.
Money for the sculpture was derived through BCBS Board of Directors Contributions Program.
Hansen said people in Lincoln didnt always know what to think of the spurs as he made them, which took him about 45 days.
He considered it a teaching opportunity.
Its important for them to realize what they are, he said.
He said the spurs are a natural fit in most of Nebraska, and were deliberately created to be viewed from every direction.
Its important that the audience interacts (with art), he said. The sculpture encourages you to walk around it to look at it from all sides, so its more likely to involve a person and evoke a response.
The spurs have the natural rusty appearance of metal that is exposed to the elements. That surface was preferred for practical as well as artistic reasons. For art, rust represents the history and earthiness of cowboys. In practice, the spurs will be picked up and moved many times as they travel to Cattlemens Balls for years to come, so paint would get scuffed, scratched and chipped anyway.
To take part
A person need not attend the Cattlemen's Ball to take part in the Serenity Spurs ribbons project, said Kimberley Kaschke of First National Bank.
The Serenity Spurs provide our community the opportunity to get involved with the cause in a meaningful way, she said.
Although the Cattlemen's Ball raises money in support of cancer research at the University of Nebraska, part of the money that is raised stays in the immediate area to support health care-related causes.
We encourage the community to visit the Spurs while they are on display, Kaschke said. Reserving a ribbon not only honors the courage shown by a loved one touched by cancer, but also goes to support cancer research right here in Nebraska.
To commission a memorial ribbon for the big spurs, contact First National Bank at 308-532-1000.
Hansen on technique
"Most sculptures start from sketches, which are uploaded to CAD modeling software, altered and then fabricated," Hansen said on the Modern Arts Midtown of Omaha website. "I work with carbon steel, stainless steel and aluminum. Surface finishes include grinding, sanding, anodizing natural rust patinas and acrylic urethane painting."
I had the skills and knowledge to build sculpture before I developed a keen interest in art and sculpture, he said. I have used my technical training to express myself and explore the sculptural possibilities that compel me to make these forms. I embrace the creative process the act of making and seeing and leave the meaning to the viewer.
First published in the May 22 print edition of the North Platte Bulletin.
Flatrock Publishing, Inc.
1300 E 4th St., Suite F
North Platte, NE 69101


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Protein has traditionally been the most expensive ingredient in the diet of lactating dairy cows. Doing the best job possible of utilizing protein in the diet can not only save money, but improve feed efficiency and help to decrease nitrogen excretion, says Tamilee Nennich, Purdue Extension dairy specialist.
Milk urea nitrogen (MUN) values are a quick and easy way to measure protein and nitrogen utilization in dairy cows. Nennich discusses this subject in the latest Purdue Dairy Digest podcast.
To download episode #104 "Milk urea nitrogen," click here.
Source: Purdue Dairy Digest


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The J. R. Simplot Company is announcing a new line of products called Simplot ONE, for Optimal Nutrient Efficiency.
Optimal – provide premium products that deliver superior solutions for our customers.
Nutrient – develop advanced nutrient delivery systems based on science and technology.
Efficiency – respect resources and the environment by promoting the principles of 4R Nutrient Stewardship.
Simplot ONE products are a premium line of fertilizers, coatings and potentially other technologies geared toward the advancement of plant nutrition. The cornerstone to the Simplot ONE brand will be a commitment to its defining principles: providing economically viable solutions to our customers, continual advancement of technologies, respect for resources and the environment.
"Using the best products to produce the best results for our customers has always been our goal," said John Malinowski, vice president of business development and marketing for Simplot AgriBusiness. "In introducing this new line of products, Simplot AgriBusiness is able to uniquely provide real results in the field. It truly blends our focus on science and technology with innovative options."
It also shows the Simplot dedication to sustainably growing our business. This line of products enables Simplot to really enhance the mission of "Bringing Earth's Resources to Life." Garrett Lofto, president of Simplot's AgriBusiness, adds, "There is a tough road ahead of us all in feeding the world. We take this challenge seriously by looking for innovative solutions both in products and the way these products are used. The Simplot ONE way of doing this will provide us with better options we need to meet and exceed demands of the future."