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May 10, 2013
Dissecting the Draft
Due Diligence
With our first-round targets broken out into three tiers, per our last installment of the Dissecting the Draft series, we are ready to start breaking down our decision-making tree, starting with Tier One. As a recap, here is where our tiers currently stand for our first pick in the draft (seventh overall), in each case in alphabetical order:
Tier One
Tier Two
Tier Three
Moving forward, we'll start pieces in this series off with a recap of our tiers as they currently stand, which will include ranking by preference as we approach draft day. Additionally, we'll eventually have full reports on all of these candidates linked in the summary section.
Planning for the Unlikely
The majority of the heavy prep work will center on Tier Two candidates, as we more fully examine below and in our next two pieces. Still, it is incumbent on decision-makers to ensure that due diligence is performed on all potential selections, and particularly with regards to talents whose availability at slot would be considered a windfall. Our Tier One list spans just three players, and our slot is seven players in. Minimal prep work leading up to the draft will afford us the luxury of not scrambling to make alternative plans should one of these players drop to us unexpectedly.
Anticipating Ripples: Three Options
The largest ripples in later draft selections will come when the Tier One player dropping to us will require a significantly higher bonus than is currently allotted to our draft slot. For this reason, it is of the utmost importance to have as firm an understanding as possible as to what if will take (ballpark) to ink your Tier One players should they fall to you. While it is unrealistic (and technically against draft rules) to expect to obtain specific bonus amounts from would-be draftees, we need to have some idea as to whether selecting the player will require an additional $500,000, $1 million, or more than our current slot allows.
If a player falls into this category, the optimal approach to managing ripples further down the draft is two parts. First, the late single-digit rounds should be utilized to bank extra money (generally by selecting players that will be willing to sign for nominal amounts, so as to free up as much of their slot allotment as possible). In certain instances, it may be necessary to select a third- or fourth-round player one round early in order to save some additional money there. Obviously, this will take its toll on the strength of your draft class as a whole, making the quality of your scouting and player valuation even more important.
Finally, you will want a back-up plan or three, preferably starting in the 11th round, so that should you fail to sign your first-rounder, the money you have otherwise saved can be put toward something of value. As a reminder, if you fail to sign your first-round pick, you do not have access to that allotted money. Rather, we would be spending the money saved in other rounds on our "back-up plans."
The second Tier One ripple comes when the Tier One player dropping to us will require slightly higher bonus money than is currently allotted to our draft slot. As you might expect, these ripples are smaller than those in the scenario above, and can generally be limited to two or three of your final picks in the top ten rounds being utilized to free up cash (signing a player for a nominal amount in order to repurpose their slot allotment). This strategy should also be paired with at least one significant back-up plan post round ten, and still leaves room, generally, for one more aggressive play in the top five rounds, so long as you are willing to leverage your lower single-digit-round picks to continue to free up additional money. Again, the quality of your player evaluations is key, as you will need to excel in finding value while targeting players generally expected to come off the board later than you select them.
The third and final category of ripples is caused by selection of a Tier One candidate that could reasonably be expected to sign for around what our slot allotment affords us. This will only happen if the Tier One candidate is someone you have rated more highly than the teams picking ahead of you (such that the player and his advisor have an industry valuation set somewhere around your slot amount), or if the player simply has no interest in continuing scholastic ball and is dead set on turning pro. In either case, this is the ideal situation, where we are able to land one of our preferred picks without having to sacrifice flexibility in actions later in the draft. So, what sort of ripples do we expect to run through our draft if our Tier One candidates are available to us?
Setting Our Options and Expectations
Appel is a senior sign turning 21 this July, and he should generally be interested in signing for top-ten money. More importantly, he has enjoyed a highly productive senior year and has positioned himself to come off the board high enough that offered money should not be an issue. His leverage in negotiations will stem from the fact that the draft is fairly light on elite talent; Appel represents one of just a few players that would generally be able to demand top three overall money in a given draft class. That said, he is ready to start his pro career from a developmental standpoint and could be in the majors late this year or, more likely, early next year. There is little reason to put off the start to his career at this point, so we would view him as either a moderate ripple or light ripple risk—meaning were he to fall to us for some reason, I would expect we can sign him for around slot allotment or without going significantly over our slot allotment.
As a junior, Gray has a little more leverage than does Appel in that he has another year of eligibility at Oklahoma. Additionally, as is the case with Appel, Gray is one of a very small group of players that should almost universally be considered the elite of the draft class. The organization's leverage will come from Gray's limited track record and the fact that he should have a strong incentive to start his career now, as make the bigs as early as next summer, while holding out and re-entering the draft would likely push back his debut to late 2014 at the earliest. Finally, it's worth noting that while a lot can change between now and next June, the 2014 class looks to be deeper up top, meaning Gray could have stiffer competition for the top couple spots in the draft class. As is the case with Appel, Gray should be viewed as a moderate ripple or light ripple risk, notwithstanding any changes in his profile between now and draft day.
Frazier has the most leverage of our Tier One triumvirate, based on his alternative options to signing (namely, heading to college—be it through honoring his commitment to Georgia or enrolling in a junior college and re-entering the draft next year). There is room for significant improvement in his signing bonus if Frazier can head to school and emerge as a candidate for first overall come June 2016, but by starting his pro career now, he would give himself the chance to be breaking into the majors that June, rather than waiting to start his minor-league career.
There are also some questions organizations could have relating to his profile type—namely, his lack of physical projection and the fact some teams may question whether he is a center fielder or corner outfielder, long-term. All factors considered, and notwithstanding actual bonus figures that may be leaked at a later date, Frazier should be viewed as a moderate ripple risk, with a fair chance at signing at slot allotment.
Ranking Our Options and Game Planning
1. Jonathan Gray – 58/65 (2014)
The two arms provide us with the highest "overall future potential," or OFP, as well as the shortest developmental investment required. Those benefits, however, come with the additional risk of injury inherent with arms, as opposed to position players. Further, because Frazier is further from fully baked, he stands a better chance of outdistancing his OFP (likewise carrying a greater risk of failure due to his further proximity from major-league readiness).
With OFP as our strongest factor, we next look at the comparative ripples these selections would have on the rest of our picks. As noted above, all three selections figure to have moderate to negligible risk of requiring heavy adjustments later in the draft, making this aspect of our analysis essentially a wash. Further simplifying the matter is the fact that our Tier One only runs three players deep, while our slot will see six players selected before our pick.
Appel and Gray are the clear top arms in the class and, barring injury, are a lock to be off the board given the other options available to the six teams drafting ahead. Further strengthening their cause is the fact that both measure up well with $4 million-plus arms selected in recent drafts, making it unlikely that teams in the top four picks would pass on them. In short, asking price isn't going to push them down the board to seventh overall.
Frazier has a fair shot of being available when our slot rolls over. Some organizations will shy away from Frazier due to their preference to select high school players with more physical projection in their game, swing-and-miss concerns (which would limit the utility of his big-time power tool), and some may not be sold on him as a center fielder. He grades out for us as a top-five guy due to adjusted OFP, which takes into account some intangibles that bump up the overall profile, but by straight tool evaluation, he could be closer to a top-15 talent. Generally speaking, Frazier could come off the board anywhere in the top half of the first round, all things equal, which is an ideal spot for us so long as he is intent on signing and starting his career. He is our best opportunity to grab a Tier One talent, and the only such talent on our board that seems like a possibility to drop to us at seventh overall.
In other situations, we might consider certain other outside variables, including how our first-round pick might pair with the likely available talents in the second and third rounds, as well as organization specific needs, when looking to differentiate between three similarly valued players. Were we selecting first overall, we would be forced to delve deeper into the Appel/Gray comparison (and perhaps we'll take a look at this in any event as a one-off draft piece later this month), but considering the chances of us having the opportunity to draft either is just a hair over nil, we will not invest that time and effort at this point. We will simply opt for the slightly higher upside of Gray over the slightly higher probability of Appel, so as to add structure to our Tier. But essentially we have a 1a and 1b in Gray and Appel, with Frazier rounding out Tier One:
1. Jonathan Gray
Looking Ahead
Thanks, as always, for checking in. I look forward to digging into Tier Two with you next time around.
Nick J. Faleris is a practicing structured finance attorney and Sports Industry team member in the Milwaukee office of Foley & Lardner LLP. The views he expresses in Baseball Prospectus are his own, and not necessarily those of the law firm.
Nick J. Faleris is an author of Baseball Prospectus. Follow @NickJFaleris
4 comments have been left for this article.
BP Comment Quick Links
Nick, Jim Callis' mock has Frazier going at #7. If he's there do you definitely take him even if he requires more than slot?
May 10, 2013 07:56 AM
Nick Faleris
BP staff
Barring any substantive changes in Frazier's stock, or details relating to the money his looking for, Frazier would be my selection in that scenario provided Gray and Appel are off the board (a near certainty).
May 10, 2013 08:45 AM
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Professor Dawne-Marie Dunbar has spent many hours in the simulation labs working with nursing students this past month. Fundamentals 100 students and Medical Surgical Nursing 201 students have been very positive about their experiences. Comments like those listed below highlight the value of learning in the simulation labs:
"Great job! What a blast.! :-)"
"This was a wonderdul learning experience. I completely enjoyed everything and realize the value of Sim. :-)"
"Today was a awesome learning experience!"
Cindy Tack's SSW 639 class, Social Work Practice in Medicine and Health, had opportunities to hone their skills during three experiences in the simulation labs. Cindy's social work colleagues proved to be excellent actors as they played roles designed to challenge and engage. As students encountered issues related to end of life, homelessness and difficult family dynamics, they were able to practice their assessment skills, tolerate intense and raw emotions and respond to presenting needs .
Cindy Tack, our Social Work simulation pioneer, represented the UNE School of Social Work at the Council on Social Work Education's Annual Meeting in Portland, Oregon. Her topic was about the use of simulation in social work, titled Making it Real: Using clinical simulation to strengthen practice skills. As part of her presentation participants were able to view a movie (Simulation in Social Work Education) that Cindy developed in collaboration with Cynthia, who filmed and edited the production.
Dental Hygienists participated in a November Continuing Professional Education course entitled, Nitrous Oxide for the Dental Hygienist. The participants came to the simulation labs as a capstone to their course. They were able to practice what they learned in the didactic portion of their course and dealt with real issues that they might encounter in the dental clinic.
This month Ryan continued his orientation to the simulation world. He met with Eric Stehle, Vice President of Sales at Educational Management Solutions (EMS) to learn about their web based management system. He also traveled to Sarasota, Florida for training on the METI systems (Medical Education Technologies, Inc).
Ryan wasn't the only traveler this month. Our pediatric simulator, Hal, traveled around the corner to MMC's Hannaford Center for Safety, Innovation and Simulation. He was in the care of Todd Dadaleares, Chief Simulation Specialist, and was needed to help out with Emergency and Anesthesia resident training. MMC has ordered their own Hal but it hadn't arrived in time for these simulation sessions. We are always happy to help our simulation neighbors.

subset: commoncrawl


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Aviation Industry Corp. of China (Avic) is working on a "China New Generation Business Jet" (CNGBJ), the company revealed today at Airshow China 2012. A scale model of this new design is on display at the manufacturer's exhibit booth at the six-day airshow, which opened today at the airport of Zhuhai, Guangdong province in Southern China.
According to Avic, the CNGBJ is "a high-end large business jet with long range, a large cabin and high cruise speed." The aircraft, which currently exists only in scale model form, will have "full-digital fly-by-wire, highly integrated avionics and new-generation propulsion systems." Avic further claims that the CNGBJ's performance will exceed that of the Western business jets flying today. Estimated first flight and certification dates are not yet known.
"It can easily achieve a transcontinental flight and can meet the requirements of all kinds of business flights under complicated environmental conditions. The spacious and comfortable cabin allows you to enjoy the extraordinary air travels," the company said. The airplane will have a "fashionable, spacious and comfortable cabin, and global IM entertainment system, providing unparalleled office and leisure enjoyment," as well as "high dispatch rate, low operating costs, green low-carbon emission and [be more] cost-effective than same-level products."
Sergio (not verified)
November 14, 2012 - 2:10pm
And will be able to bend steel in its bare hands! Seems the Chinese are using marketing textbooks from the 50's: exaggerate enough and some moron might believe you!
The Chinese high-tech industries are today 20 years behind the West with little chance of catching up in the next 20 years. A green aviation product when their factories belch smoke and spew poison into the rivers? Seems their emphasized programs are way off target. Make the country livable for the population and then work on making a me-too showpiece.
Bruce (not verified)
November 14, 2012 - 4:41pm
I can do one better: here I have a scale model of the Starship Enterprise that will blow the doors off this jet. Warp drive: almost ten times the speed of light! Only needs refueling every 10 years! Travel to Mars in just a few minutes! Photon torpedoes and force fields for defense! Replicators on board instantly make almost anything you need (3D printers are so 2012)! Transporters let you move instantly anywhere when in orbit around a planet! Note: estimated first flight and certification dates are not yet known.
yea right (not verified)
November 14, 2012 - 7:03pm
What a load of crap. They haven't even been able to get that home grown plane flying even after copying the whole thing from the west.


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I posted this in a reply to the RATS board and thought some of you may be interested:
Roby was drafted by the Titans along with two other WR's in the 2005 draft. Of all those, he was a favorite of the Titans GM Reese (now on ESPN). His rookie season he ran ONE, yes, ONE bad route, and McNair refused to throw ONE ball his way again. But he did start just about every game and he and Pac Man Jones were probably the best 1-2 kick off return combo in the NFL. Each, I believe, averaged more than 27 yards a return.
2006 season comes and the Titans hire Chow as the offensive coordinator. Chow's offense was so vanilla that it did not exploit Roby's talents-speed, quick cuts, and good hands. He was not active for the first four games (or three) until the Colts game at Indy. He was on the KICK OFF team and throughout the season was a big reason the Titans went on the winning streak that they did. He played spottingly at WR and contributed on the kick off team making many tackles-surprising for his size but not surprising because of his speed getting down the field after the kick. He made a great catch against the Colts near the end of the first half of the game (was reviewed and upheld to be a good catch) that set up a 20 yard TD pass to Drew Bennett at the end of the first half (Tennessee went on to win the game on a 60-yard field goal). Also, Roby made the key block on a 40 yard TD run by Vince Young in OT in the Titans win at Houston. Here is the link to the play (note how none of the play-by-play guys make a single comment about the block-only how great the run was):
2007 season comes and surprise, Chow's offense is just as vanilla as before. He had a great camp and made catches like one you can see on youtube:
http://www.youtube.com/watch?v=0vRYaQAEnVo .
If you also remember during the pre-season, Vince Young went after a DB who cheap shotted a WR after a pass in a shoulder pads only drill. That WR was Courtney Roby. Here is the youtube link:
Already not a favorite of Chow, he was a favorite of departed GM Reese. Note "departed GM Reese". Without having an offense that highlighted ANY of his skills, an Offensive Coordinator that didn't fit his scheme, a new GM that did not draft him, Roby was the odd man out on a Titans receiving corps that was the pride of the USFL, er, CFL, er, I mean NFL.
He was then signed to a two-year (non-guaranteed) contract by the Bengals and was a member of the Bengals for four practices and one game (home game vs. the Steelers-he was active but did not participate in that game).
Courtney had a tryout with the Colts during the week that they activated Aromoshadou (sic?), when the Colts decided that week 13 (or some time around then) was not the time to try to get a new receiver up to speed with the Colts complicated offense though they were very impressed with Roby's workout. They were impressed enough to sign him to a two-year contract that included a signing bonus, amount of signing bonus I do not know.
Roby has been plagued by offenses that did not fit his style of play going all the way back to his middle school days at Eastwood Middle School where he was a quarterback for two years in a run-and-shoot offense that focused on the run, rather than the pass. He then had two unproductive years at a floundering Lawrence North program and transferred to North Central High School for his Junior and Senior Seasons where he was a standout wide receiver. Ironically, his top wide receiver in middle school, Eric Hooks, became the quarterback of North Central, while Roby became the #1 receiver that Hooks was with Eastwood Middle School. Hooks, incidently, just completed his career with Saint Francis College in Ft. Wayne that included two trips to the NAIA National Championship Football game.
Roby was (maybe still is) IU Football's #1 receiver of all-time statistically. This with two seasons while playing with such QB greats as Matt LoVecchio, and I'm sure some other guys. Recruited by then Coach Cam Cameron to IU, Roby is the cousin of former IU Basketball great Landon Turner (Tech), his uncle is former IU Football great wide receiver Rob Turner (Chatart), and another cousin is, arguably, the second best punter of all-time Reggie Roby (Iowa, Miami Dolphins, Washington Redskins). Going into the 2005 NFL Draft Courtney had the second best 40 time at the combine (4.34).
He is perfect for the Colts offense and I am confident that he is already working hard to make sure he is a productive member of the 2008 Indianapolis Colts. I, personally, am hopeful that he gets an opportunity to return kicks (and punts), maybe is on the kickoff team (because that part of the Colts really had a tough time this year with kick off coverage), and gets into the rotation at Wide Receiver with Wayne and Harrison. He is a strong slot receiver-played a similar position in high school, some at IU, but I foresee him more as a WR rather than a slot in the Colts offense. Hope this gives some of you some understanding of the talent that Roby possesses. Right now, I'd put him at #4 in the receiver depth chart. This does not include TE's, of course, though the Colts do sometimes use Clark and Utech (mostly Clark) in the slot position.


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Hi, I'd love several fertilized eggs as I've a hen gone "broody" and thot this could be a good way to increase my little flock. Please msg. or call me (249-4445) with the availability and price. Thank you! Hope to see everyone at the Coop Tour this weekend!
Views: 166
Eric, Thank you so much for your kind offer of fertilized eggs! And yes, I most definitely do want to meet you on Friday and pick them up.
How much are your pullets? I have 4 ladies, but 2 stopped laying 3 months ago, and now 1 is sitting on the nest all day. So, this seemed a perfect opportunity to add to the flock. Thank you again for this!
I tried your # twice and it said the no. was chg'd. So here is mine: 249-4445. Please call so we can meet. I am a massage therapist and I do have 3 appts. that day. So...no to be difficult, but here are my open times: before 9:30. between 11:30 and 12:30, between 2:30 and 3:30,then after 5:30. I do live near Eubank and I40 and if I have time, I'll meet you anywhere you need. Just let me know where/when you want.
Thank you again!
Hi, I saw your post and thought I'd let you know that the same thing happened to me -- one of my 3 hens went broody, and one of the others stopped laying because of it. I discovered that Wilbur's Farm (south of Belen) sells fertile eggs by the breed, but it's been almost two weeks and I still have not heard from them about when they will be available. I also found out that Quality Baits on Isleta Blvd (ABQ) will have one-day old Orpington chicks this Friday (18th). I researched putting chicks under broody hens and apparently, it can be done successfully just so the chicks aren't too old (1-2 days). I wanted Orpingtons in particular so I may go with this option if Wilbur's doesn't come through with my eggs sooner than later.
Good luck either way!
Thank you, Laura! I appreciate the info. I am familiar w/Quality Baits and will call them if Eric's eggs don't hatch. This is exciting and fun for me!
I like Orpingtons also - my one current layer is a beautiful buff/orange colored one I call Flan.
Take good care,
Good Morning! So happy to hear from you! I look forward to talking and meeting you - and taking care of adorable new chicks!
Be well,
Here are a couple pics of the rooster and hens
Thank you for the fun pics. I am curious about the yellow 'blinders' some of the hens have - is that to keep them from pecking other hens? Was it difficult to put them on? I do have one hen that gets aggressive and I put her in a separate pen area.
Looking forward to getting chick eggs tomorrow. Thank you again.
Hi, thanks for inquiring - I was planning on letting you know what happens...however, as of now, day 22, no eggs have hatched...sigh.
I have 6 under Peepers and 6 in a homemade incubator. (with light, water, etc.. did a search on how)
I am getting concerned about Peepers, she has been sitting on the nest for almost 4 weeks (as she went broody first, then I thot of putting eggs under her). Do you have any suggestions? She gets up about once a day and eats, and I keep water near her at the nest.
Well, maybe later today ... I hope!
Happy weekend to you both!


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Photo By: Town Crier File Photo
Los Altos High's Brian Yeager finished third in the boys triple jump at the recent Golden West Invitational at UC Berkeley.
Five track and field athletes from local schools placed eighth or better in an event at the 54th annual Golden West Invitational, held June 9 at UC Berkeley's Edwards Stadium.
Los Altos High's Brian Yeager, who just completed his sophomore year, took third in the boys triple jump with an effort of 42 feet, 3 inches.
Older brother Danny Yeager, who graduated from Los Altos last month, finished fifth in the boys 300-meter hurdles with a time of 39.78 seconds.
Willem Van Eck, who graduated alongside Yeager, clocked an 11.44 in the boys 100 dash to place eighth.
St. Francis High grad Cody Bickham, entering his sophomore year at Cal, finished fourth in the men's discus throw. Competing on his home turf, Bickham unleashed a throw of 164-6.
For the girls, St. Francis' Micha Auzenne placed fourth in the 100 hurdles with a time of 14.31. Auzenne graduated from St. Francis in May.
For more information on the meet, visit goldenwestinvitational.org.


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Pepe Aguilar Tickets
Pepe Aguilar wass born in San Antonio, Texas, a sun-baked nirvana for those who love to bask in the hot peppers, cantinas, and fiery sunsets of America's latin fringe. Aguilar is of Mexican decent and a master of a musical form known as ranchera, which is believed to have originated in the State of Jalisco, and has close ties to mariachi music. He is the son of Mexican entertainment stars Antonio Aguilar and Flor Silvestre. Agular's creative roots are both authentic and pure; his father is a singer and an actor, who took his family to Puerto Rico for several years, back when he was struggling to make it in showbusiness. This proved to be fertile ground, and certanly helped the family bolster their latin awareness, and merge their Mexican culture with that of the beautiful island in the sea. Aguilar made his singing debut in 1973 in front of a large crowd at Madison Square Garden. He remembers being scared by the crowd and he admits to actually crying when confronted with the adoring throng. Eventually, he became part of his father's act, and found solid singing feet as a young man.
Aguilar was a member of a teenage rock band called "Equs", but they did not last as a unit. Experience in the band led to Aguilar making his first CD, and his early influences he cites as Pink Floyd, The Who, and other giants of that era. Aguilar's 1990 album saw him debut in style, and Pepe Aguilar con tambora ("Pepe Aguilar with a Conga") made more than a few exotic ripples in Mexico and Latin America. He released several more CDs into the 1990s, and even tried his hand at the production side of things, his early showbusiness backgroud helping him to feel comfortable with all aspects of the recording and performing process. Aguilar started two record labels and produced songs for Lupita D'Alessio, Lupe Pineda, and Julieta Venegas, plus many more artists.
In 1998, Aguilar released Por mujeres como tu ("Because of Women Like You"). The record hit two million copies worldwide and was on the Billboard hits list for fifty-two straight weeks, bringing a fresh glow to what was already a momentous rise to stardom. As the millennium turned, Pepe gathered pace, and began releasing more work, including the 2000 hit album, Por una mujer bonita ("Because of a Beautiful Woman"), for which he was given a Latin Grammy award. He now has a total nine Grammy nominations, as well as nominations for other awards in various musical spheres.
Aguilar has also served as a catalyst for the enhancement of latino culture and visibility of that culture on the world stage. He was the first Mexican regional music singer to perform at the Hollywood Bowl. On September 15, 2003, Mexican Independence Day, Aguilar was given the symbolic keys to the city of Los Angeles. An estimated number of 20,000 people watched the ceremony.
He joined the Sony label in mid-2004 and continued making new albums. No soy de nadie ("I Don't Belong to Anyone") was released later on that year, and again the fans were treated to a blistering array of traditional Mexican sounds which conjured gorgeous images of that mysterious and triumphant nation. Aguilar recently sang the Mexican national anthem before the sensational Floyd Mayweather-Oscar De La Hoya fight, proving his childhood fear of large crowds is most certainly over.
Pepe Aguilar tickets are on the move again, and anybody who appreciates an excellent and sumptuous evening of solid authentic latin sounds will make sure to grab one. Seats at Pepe Aguilar concerts tend to be occupied by people who live life, who dance to the rhythms and sing when they are happy and when they are sad, and there is no song like a Mexican song, when it comes to living life. Be one of the lucky ones who see this amazing performer at work, and bring a hankerchief, for you will be moved to tears by the power and virtuousity of this latin entertainer.Buy Pepe Aguilar tickets and enjoy the concert of a lifetime. A live performance by Pepe Aguilar is a celebration of music, no matter if the venue is an intimate club or a packed stadium. In addition, all tickets are guaranteed, and are typically 10 to 20 percent cheaper than the competition.


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Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network (VCAT)
This study has been completed.
Agency for Healthcare Research and Quality (AHRQ)
Information provided by:
Agency for Healthcare Research and Quality (AHRQ)
ClinicalTrials.gov Identifier:
First received: July 17, 2007
Last updated: January 7, 2014
Last verified: September 2007
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
Many women present in primary care with vaginal complaints. The best way of managing these complaints is unclear. This trial will test two different methods of managing patients with vaginal complaints. This is a pilot trial.
|Drug: Terazol or oral fluconazole for candidal vaginitis Drug: Metronidazole or Clindamycin for Bacterial Vaginosis Drug: Flagyl for definitively diagnosed vaginal trichomoniasis Other: Empiric Management
|Early Phase 1
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Management of Vaginal Complaints: A Pilot Study Within a Practice-Based Research Network
Resource links provided by NLM:
MedlinePlus related topics: VaginitisU.S. FDA Resources
Further study details as provided by Agency for Healthcare Research and Quality (AHRQ):
Primary Outcome Measures:
- Self-reported improvement in symptoms [ Time Frame: within 2 weeks ]
Secondary Outcome Measures:
- Adverse reactions to treatment. [ Time Frame: within two weeks ]
- Incidence of STD's [ Time Frame: at time of presentation ]
- Vaginal Complaints Scale [ Time Frame: within 2 weeks ]
|Study Start Date:
|February 2007
|Study Completion Date:
|February 2008
|Primary Completion Date:
|February 2008 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Intervention
Patients primarily with itching or irritation are treated for candidal vaginitis. Patients primarily with vaginal odor are treated for bacterial vaginosis. Patients who did not fit either of the previous groups are treated for both candidal vaginitis and bacterial vaginosis.
Drug: Terazol or oral fluconazole for candidal vaginitis
Intravaginal terazol qhs x 5 nights; oral fluconazole 150 mg po x 1Drug: Metronidazole or Clindamycin for Bacterial Vaginosis
Metronidazole 500 mg bid x 5 days; Intravaginal metronidazole bid x 5 days; intravaginal clindamycin
Other Names:Drug: Flagyl for definitively diagnosed vaginal trichomoniasis
Metronidazole 2 gms po x 1
Other Name: FlagylOther: Empiric Management
In this arm of the study women are treated for vaginal complaints purely on the basis of their symptoms.
Other Names:
Active Comparator: Control
Patient are examined and a wet mount is prepared. If a definitive diagnosis is made patient is treated for the condition diagnosed. If no diagnosis is made the clinician has the option of either foregoing treatment (watchful waiting) or following the protocol in the experimental group
Drug: Terazol or oral fluconazole for candidal vaginitis
Intravaginal terazol qhs x 5 nights; oral fluconazole 150 mg po x 1Drug: Metronidazole or Clindamycin for Bacterial Vaginosis
Metronidazole 500 mg bid x 5 days; Intravaginal metronidazole bid x 5 days; intravaginal clindamycin
Other Names:Drug: Flagyl for definitively diagnosed vaginal trichomoniasis
Metronidazole 2 gms po x 1
Other Name: Flagyl
Detailed Description:
Setting: The study will be carried out at two sites within the New York City Research and Improvement Network (NYC RING) an urban Practice Based Research Network comprising 21 clinical sites. Problem: Vaginal symptoms are the most common reason for outpatient gynecological consultation, yet the management of these symptoms is not well grounded in evidence from primary care. Purpose: To prepare for a randomized clinical trial (RCT) to test whether the current standard of care for evaluating vaginal symptoms (which involves looking for specific pathogens) produces better clinical outcomes than a simpler approach, which treats patients based on their symptoms. Methods: 55 premenopausal non-pregnant adult women presenting with vaginal complaints will be randomized into two groups. Women in Group A will be managed on the basis of presenting complaint without physical examination or office laboratory work. Women in Group B will receive a physical examination and office evaluation looking for trichomonads, candida and bacterial vaginosis. They will be managed according to the clinical and office laboratory findings. Patients will be contacted by phone two weeks after consultation to assess symptom resolution, adverse reaction to drugs, satisfaction with care and treatment experiences. Patients will be screened for infection with gonorrhea and chlamydia using a urine antigen test and for trichomoniasis using vaginal culture. Patients whose tests demonstrate trichomoniasis, chlamydia or gonorrhea or who remain symptomatic at the two-week follow-up call will be re-evaluated promptly. Outcomes: AIM 1: Feasibility: The pilot will assess 1) ability to recruit and retain patients, 2) acceptability of study protocols to subjects and 3) prevalence and detection of important sexually transmitted diseases (STD's). AIM 2: Initial evidence of effectiveness: The pilot will provide data on key planned RCT outcome measurements including 1) treatment success rates (allowing estimation of future sample size), 2) need for reconsultation 3) adverse reactions, 4) medication usage and 5) patient satisfaction. Benefit to public health: This pilot study will lead to a RCT of the management of vaginal complaints in primary care. This RCT may support current practice, reinforcing the need for physical exam and laboratory testing in all patients. On the other hand, the trial may support a more limited approach that avoids a pelvic examination. This could result in substantial savings of health care dollars with equivalent clinical outcomes.
|Ages Eligible for Study:
|18 Years to 52 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Eligible patients will be premenopausal, non-pregnant women presenting with a chief complaint of vaginal itch, malodor, discharge, pain, irritation or rash. We will accept patient history of being pre-menopausal as valid.
Exclusion Criteria:
- We will exclude women over 45 who have undergone hysterectomy. We will exclude patients who cannot be reached by phone for follow-up interviews. We will exclude pregnant women because of concerns that the diagnosis and treatment of bacterial vaginosis plays a role in pre-term labor prevention.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00503542
Please refer to this study by its ClinicalTrials.gov identifier: NCT00503542
|United States, New York
|Family Health Center
|Bronx, New York, United States, 10458
Sponsors and Collaborators
Agency for Healthcare Research and Quality (AHRQ)
|Principal Investigator:
|Matthew R. Anderson, MD, MSc
|Montefiore Medical Center
More Information
Keywords provided by Agency for Healthcare Research and Quality (AHRQ):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Matthew R. Anderson, MD, Montefiore Medical Center
|ClinicalTrials.gov Identifier:
|NCT00503542 History of Changes
|Other Study ID Numbers:
1R03HS016050-01 ( U.S. AHRQ Grant/Contract )
|Study First Received:
|July 17, 2007
|Last Updated:
|January 7, 2014
Keywords provided by Agency for Healthcare Research and Quality (AHRQ):
Bacterial Vaginosis
Vaginal trichomoniasis
Vulvovaginal candidiasis
Additional relevant MeSH terms:
Vaginal Diseases
Genital Diseases, Female
Clindamycin palmitate
Clindamycin phosphate
Anti-Infective Agents
Antiprotozoal Agents
Antiparasitic Agents
Anti-Bacterial Agents
Protein Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antifungal Agents
14-alpha Demethylase Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Steroid Synthesis Inhibitors
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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I was all set to write you a long post about the proposed USDA guidelines for 2010 when we got a visit from our friends Tim and Judy Cebulla. You may remember Tim as our Myrtle spurtle maker from Wood I Kid You? Well, what they brought by for Matt is far more fun for a Friday than the USDA guidelines (we'll get to those next week).
Tim and his wife, Judy, stopped by our mill today to drop off a surprise for Matt (our world champion)—a beautiful, hand-crafted doll. Judy sells her dolls, along with other hand-crafted items through her store front Threads of Magique on Etsy.com.
We can't get over how much the doll resembles Matt, chef coat and all! It kind of reminds us of the dolls from Coraline, but we're going to put that out of mind and focus on the awesomeness of this little guy. Good luck charm for the 2010 competition? Check!


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BWW Interviews: Anthony Rapp on Love, Loss and WITHOUT YOU
Anthony Rapp is perhaps best known for originating the role of 'Mark' in the Tony Award Winning Musical RENT, a show that focuses on a group of friends suffering through the perils of homelessness, disease, drug addiction, grief, loss and love. Anthony dedicated many years of his life to the music of RENT in one way or another, and in 2006 he wrote a bestselling book titled 'Without You: A Memoir of Love, Loss and the Musical RENT.' The poignant novel examines Anthony's life both before and after RENT, but uses the show's powerful themes to explore some of the more difficult events he experienced, including the death of his mother from cancer and the death of RENT author Jonathan Larson on the eve before opening night.
About a year after sharing his story with the world, Anthony began the process of turning the some three hundred and fifty paged book into a theatrical experience. The resulting show is 'Without You' and has just landed on stage in Toronto after very successful runs in Edinburgh and London's Menier Chocolate Factory. BWW caught up with Anthony to talk about the process of turning his book into a show, what life is like after you lose people you love, and why 'Original Cast Member of RENT' will always be the lead line in his obituary:
Congratulations on the success of Without You! When did you first decide to write the book?
I was encouraged and asked to consider writing it by a publisher. I said yes immediately not really knowing how I was going to do it, or how hard it was going to be. It ended up being the hardest thing I've ever done creatively speaking.
Writing 'Without You' took place over a number of years, with long periods of time where I wasn't writing much at all. And then near the end it all came out in a gush. I had tried so many things over the years, scheduling time to write, making goals or not making goals, but there really wasn't any rhyme or reason to it. It was like a marinade, it was ready when it was ready.
How did you decide to turn it into a show?
The book came out in February of '06 and in the summer of '07 a young producer asked me if I had ever thought about turning it into a show. I didn't even know where to begin so I contacted a good friend of mine and asked what he thought. He did me the great service of helping take the 300+ pages and condense it to around 100 pages. I didn't know where to begin chopping it up and had no objectivity whatsoever.
Once it was condensed I began to see how the show could possibly take shape. We did a reading which was open to the public and I invited people I really trusted like my brother Adam and Michael Greif - people I knew wouldn't bullshit me. I honestly didn't know if it could work as a theatrical event because it's a very different animal, but the response was so positive and every person encouraged me unequivocally to keep going.
What was harder, the book or the show?
The book. No question, it's not even remotely close. I think writing is very lonely, and not just in the 'I feel alone' sense but in the sense that it's a lonely process. As an actor there is a lot of collaboration and having those other minds and hearts helps shape your work. When I was writing Without You I would share some of the material with other people, but it was much harder to get clarity and just go for it. It was a very solitary experience.
You mention in your book how you felt very similar to the character of Mark in your real life - did writing this book help you come out of your shell?
I'm not sure it was a question of coming out of my shell, I don't think I was ever shy. What I meant when I said that was that I often struggled with talking about emotional stuff and I didn't find it very accessible. I was afraid of those types of conversations and feelings more than I am now. When I was writing the book I was never afraid to share, and there was even a certain amount of liberation to the whole experience.
I think the only thing I was afraid of was that I know I have a lot of younger fans and there are some darker moments in the book that I was concerned they might not completely understand. For instance, I once read someone on a message board say in reference to my book that 'beating up your boyfriend doesn't make you cool'. I knew that, I didn't include that because I was bragging or glorifying what I did. I put that material in to show that sometimes we can do horrible things, and have awful things happen and we can still heal, make amends and forgive. So sometimes I'm afraid of misunderstandings, but overall I think people have embraced and understood the material.
The subject matter is very heavy, how do you handle addressing the death of Jonathan Larson and your Mom in your show every single night?
The fact of my Mom's death or Jonathan's death are facts of my life. They're things that I have to live with every day whether I'm on stage or not. There are days where I feel the sadness more keenly and there are days where I just feel fondness, love and gratitude. Sadness over the loss of someone is commensurate with the love that you had for them. Because of that, I'm not afraid of the sadness, it is part of what it means to be alive. Losing people is part of loving people, and I think it's incredibly rare to go through life and never lose anyone.
There are certainly moments where it is heavier than others but I weather that storm, move through it and come out on the other side. It's nothing to be afraid of and doing the show never really feels 'heavy'. It feels intense and rigorous but I feel like it's alive and the people in it are alive to me for those eighty minutes. It brings them to life when I tell their story and I evoke them when I share their voice and their words. I feel close to them and the audience response is enriching and gratifying.
Do you think that the losses you experienced made you more driven? Did it ever make you acutely aware of how short life is and make you want to make sure you accomplish certain things?
Not really, I've always been a very driven person. For me RENT was in many ways the culmination of everything I've worked for my entire life. That's not to say I haven't done other things that I'm very proud of, but I feel like in a way everything after RENT has just been gravy. If I were to die right now, or even twenty years from now, I feel like the lead line of my obituary is likely always going to be 'Member of the Original Cast of RENT'. It will probably go down as the most notable thing in my life.
And does that make you happy?
Sure. It was a once in a lifetime opportunity. The original cast members of A Chorus Line have gone on to other things but I imagine people will always remember them for that show. I don't think people think of Gilmore Girls when they think of Kelly Bishop - they remember her for being a Tony Award Winner for A Chorus Line. It had a huge cultural impact and was transformative and RENT was as well.
So in that sense the losses I experienced in my life never made me feel like I had to write this book before I died, I feel like almost anything that happens to me from this point onward is just a great thing I get to do. I'm sure other amazing things will happen in my life, but if I died tomorrow I would die happy.
How about regrets? Do you purposely try and live the message of 'forget regret'?
Absolutely. I try hard not to have any regrets. My life is pretty hectic in terms of travel and work and when I'm in these periods where I'm working a lot it can be hard. When I got RENT it was the first time in my adult life where my world became really crazy, and it filtered out people who were more casual acquaintances than true friends. Even now with this path that I've chosen there are certain sacrifices in terms of the amount of time I can spend with my core group of friends, but they understand. The life we live in this business is very different from most human beings in so many ways. I understand that more and more the older I get - the landscape of the world that I live in is very different from 'average'. And sure I've made mistakes and I've hurt people and I've screwed up, but I don't think I have any real heavy regrets.
As you get to have all these amazing experiences in your life, do you ever have a niggling feeling of sadness when you think about things your Mom would have loved to experience?
Sure. I think about her a lot when I travel. She didn't express a lot of regrets before she died but one thing was that she wished she had traveled more. So in those situations I think of her, and certainly around the holidays. She loved cities and she loved to walk, and most of the places I go are great walking cities.
I remember on the first anniversary of her death I was in London doing RENT and that day was in many ways harder than the day that she died. I think that's true for a lot of people who lose someone, because you become acutely aware of how much life has carried on in their absence. Plus it was hard because she wasn't there and I know she would have loved it.
We were also starting to become adult friends, and starting to talk more and become closer. I'm sad that we didn't get to continue that and I think we would have been able to become even more open had she not passed away.
She was with you in Toronto when you filmed Adventures in Babysitting. Now that you're back in the city do you have specific memories of her time here?
She loved it in Toronto. She loved to walk and this is a great city for that so she explored a lot. I didn't have a lot of free time when I was here but I do remember going to those big record stores on Yonge Street and hanging out in arcades at night playing Super Mario Brothers.
For people who don't know the musical RENT or anything about Jonathan Larson or your book, what would you say to encourage them to come and see the show?
When I go to the theatre what I want to experience is heart, soul and truth. I want to feel like life is being reflected back at me. That I can find a mirror of human experience on stage. I feel like my show is that, so if that's something that someone goes to the theatre for than I think they will enjoy my show.
Musicals often don't do that, they're more focused on the glitz and the entertainment value. I think my show is entertaining, but we use music to help tell a story in a way that many musicals don't. I think we are successful in doing that in an effective, moving and meaningful way. I met a couple in Boston when we workshopped there and they had never heard of RENT, didn't know that Jonathan had died and they were very taken with the whole show. They were interested and engaged in the entire story, not just the parts they assumed they could relate to. I think that's encouraging.
When and Where?
Without You
The Panasonic Theatre
On now until January 6th
Tickets are $25 to $79 and can be purchased in person at the box office, by phone at 416-872-1212 or online at www.mirvish.com
Without You is the second show in the Off-Mirvish Season. For more details please visit their website here
There are a limited number of $20 rush tickets available in person at the box office two hours prior to the show.
Related Articles
From This Author Kelly Cameron


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Another Veterans Day has come and gone. It was the seventh since I first watched my son go to war.
At our house, we had put up a new flag to honor those who have served our country in past wars and to pay tribute to those still serving today at home and overseas. The pain of war felt sharper on that day than it does on other days.On the evening news programs, images of President Obama placing flowers at the Tomb of the Unknowns and walking through Section 60 at Arlington National Cemetery brought tears to my eyes. I wonder how many viewers felt the sadness.
For so many today, military service has no part in their lives. Veterans Day is just another vacation day, and the conflicts in Iraq and Afghanistan do not impact their families.
This cannot be said for the South Bay Blue Star Moms who chose to spend their day marching in the Veterans Day parade in San Jose. They have sons and daughters who are serving in the Army, Marine Corps, Navy, Air Force and Coast Guard. The lucky moms are thankful that their children are stationed outside of a war zone.
They stand by, and sometimes hold up, those other moms whose children are deployed on the other side of the world in harm's way 24 hours a day, seven days a week.
I am so very thankful that my son returned home safe and sound after both of his tours to Iraq. I have two friends who are Gold Star moms. Their sons came home in flag-draped coffins. Hoping that their sons' service to our country will not be forgotten, my friends host yearly memorial celebrations to honor their children.
I will never forget Ken or Travis. I think of them, and I remember the Marines killed in two CH-46 Sea Knight helicopter crashes in Iraq at the same time my son was there in 2003.
These memories leave an ache in my heart that never quite goes away. I can only imagine the pain that the Gold Star Moms feel.
As of Veterans Day in 2009, our country had lost 4,362 service men and women in Iraq and another 918 in Afghanistan. I grieve for the fallen and their families.
Each year, I hope for an end to the wars in the Middle East. I want all of the children of Blue Star Moms to come home. I do not want to go to any more memorial services.
But as long as the conflicts do persist, I offer my plea to those without a military connection.
In this time of Thanksgiving, please take time to reflect on the sacrifices being made daily by our soldiers, marines, sailors, airmen, Coast Guard members and especially their families.
Be thankful for our volunteer service men and women who are willing to put their lives on the line to protect the freedoms that belong to all of us.
Diane Ducey is a Mountain View resident. For nine years, her son was a CH-46 helicopter pilot in the Marine Corps. "My memories of his being in a war zone never go away," she said.


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Believe In People Mug
No longer available
- Overview
Wise words deliver an encouraging message with every sip of coffee or tea.
- 4.75" wide x 3.75" deep x 4" high
- Made of ceramic and detailed with an inspirational decal.
- Dimensions + Care
- Dishwasher safe.
- Shipping Info
This item will arrive in 3-5 business days. Please proceed to the Payment & Review page of Checkout for a precise delivery estimate.
- Final Sale
Final-sale items, identified by a price ending in $0.99, cannot be returned. Once placed, your order for any final sale items cannot be canceled.


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- In response to: Faulconer, Aguirre had late tax issues
I have for years applauded the U-T Watchdog series. However, I draw the line at non stories being reported there as important need-to-know news.
To me it is not news that a mayoral candidate paid a $104 penalty for making two very small supplemental property tax payments late. Neither is it news that once upon a time, four years ago, another candidate was once tardy in paying a regular property tax payment.
This totally irrelevant story, masquerading as hard news, is a sophistic disservice to U-T readers by being prejudicial while reporting on insignificant events. These minor penalties for even more minor transgressions are, to me, too trivial to report as news no matter who the offender was.
Jerry Hermes
San Carlos


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Constituent Services
Frequently Asked Questions about the New Mexico Public Education Department
Address & Directions for the NM Public Education Department's Main Building
The Public Education Department's main building is located at 300 Don Gaspar Avenue in Santa Fe between Alameda St. & Paseo De Peralta. Our building sits on the corner of De Vargas St. & Don Gaspar across from the Capitol North Bldg. Don Gaspar is one way and you must access it by taking an east/west street such as De Vargas, Alameda, Water or San Francisco Streets. Metered parking surrounds our building and the rate is 25 cents per 15-minute interval. The parking meters accept quarters, dimes and nickels. There is also free parking in the Capitol Parking Garage on the corner of West Manhattan Avenue & Galisteo Street that has space for public parking. Parking is currently free in this garage west of the Capitol. The entrance to the garage is off Galisteo.
Here is a Google map of our main location (click the picture):
Adequate Yearly Progress (AYP)
After School
Employment Opportunities
GED Transcripts
Home School Applications
Instructional Hours
Private Schools
Retirement Benefits
School Records
State Agency Information
Student Testing
Vendor Questions


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Mi-San Acres O Lust-ET, exhibited by David Riley of Williamsfield, Ohio wins the International Milking Shorthorn Show at the 2012 World Dairy Expo and the $1,000 Udder Comfort Grand Champion Cash Award. Lust was the Intermediate Champion Female as well as the winner of the Senior-Three-Year-Old Cow class. She is familiar to the colored shavings as she took home the Grand Champion award of the International Milking Shorthorn Junior Show at the 2011 World Dairy Expo. The Reserve Grand Champion of the Show was the Senior Champion Female, Five-Year-Old class winner Halpins Reyfene, exhibited by Halpin Farms of Kempton, Ill.
Premier Breeder was awarded to Innisfail of Orland, Calif. Halpin Farms of Kempton, Ill. was named Premier Exhibitor of the show for the second year in a row. Kuszmar Alfairs Othello was once again named Premier Sire.
Judge Steve White from New Castle, Ind. and Associate Judge Ken Empey from Dorchester, Ontario placed 196 cattle at the International Milking Shorthorn Show.


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- Overview
- Specs
- Reviews
Castelli Sorpasso Bib TightsCastelli has put all their best technologies into these exceptional cycling bib tights. Progetto X2 chamois, Giro++ straps and a mix of fabrics, including Thermoflex Core Due. The Sorpasso is lighter, warmer, drier. Now you're ready to put in those long base rides all winter long.
- Rosso Corsa label indicates Castelli's very best product
- Thermoflex Core Due fabric uses a hollow-core polyester inner layer to trap warm air while wicking moisture to the outer nylon/Lycra layer, where it quickly evaporates. Offers better warmth and wicking than traditional fabrics with a 20% weight savings. Plus, it rejects water, keeping your tights feeling dry even when wet.
- Thermoflex fabric with a fleecy inside traps warm air next-to-skin while its high stretch offers a streamlined fit
- Giro++ bib straps stay in place when in the cycling position
- 14-panel design easily moves with you, offers a streamlined fit and provides perfect compression for those hardworking muscles
- Soft and stretchy Progetto X2 chamois adapts to the shape of your body and uses variable thickness padding for long ride comfort
- Metallic ankle zippers with reflective tape for easy-on, easy-off convenience and visibility
- Giro++ grippers integrate well with shoe covers and keep these bib tights in place without constricting blood flow
Castelli Sorpasso Bib Tights
- video:
- 1F6AmmT2X7c
- chamois:
- Progetto X2
- drawstring:
- No
- fabric:
- Thermoflex/Thermoflex Core Due
- inseam:
- panels:
- 14
- rating:
- 4
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Basketball is anchored in very simple rules—you have to get the ball into the hoop, you can't walk while holding the ball, and you can only dunk the ball while leaping over fire. Learn more about this great game with this Groupon.
Choose Between Two Options
- $19 for a Naismith Memorial Basketball Hall of Fame visit for two (up to a $38 value)
- $35 for a visit for four (up to a $76 value)<p>
Naismith Memorial Basketball Hall of Fame
Celebrating more than 100 years of basketball history, the halls and exhibits of the Naismith Memorial Basketball Hall of Fame honor the players, coaches, referees, and others who helped the game grow to an internationally beloved sport. There are shrines dedicated to more than 300 Hall of Famers, and the 40,000-square-foot basketball megaplex also houses more than 70 interactive exhibits with audio and video components, limited-run tributes to standout teams and players, and special events. The Hall of Fame provides an outlet for freshly inspired visitors to emulate the giants of the sport: a full-size center court, where they can practice alley-oops and half-court slam dunks or attend clinics taught by players and coaches. On the way back to the car, many guests pause for a photograph next to the towering silver sphere that punctuates the buildings' exterior.
Named for James A. Naismith, the inventor of the sport, the Hall of Fame stands just "a midrange jump shot" from the site of the original game. Played on December 21, 1891, the first contest tallied a final score of one basket to zero, prompting Dr. Naismith to remove the bee's nests from the backboards.


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2015 Nissan Versa Press Kit
2015 Nissan Versa Note adds new SR and SL trim levels – continues to offer energetic styling, 40 mpg fuel efficiency and smart technology
- 2015 Versa Note now available in five trim levels: S, S Plus, SV, SR and SL
- All models features smart packaging and ample cargo space
- Available advanced features include class-exclusive* Around View® Monitor, along with NissanConnectSM with Navigation and Mobile Apps, Hands-Free Text Messaging Assistant, RearView Monitor and Divide–N-Hide® Adjustable Floor (adjustable rear load floor)
- 40 mpg highway/ 31 mpg city/35 mpg combined fuel economy (Xtronic-equipped models)
Following a highly successful debut as a 2014 model, the Nissan Versa Note enters its second year of production with a number of significant enhancements – led by the addition of new Versa Note SR and Versa Note SL trim levels. There are now a total of five models: S, S Plus, SV, SR and SL.
The new 2015 Versa Note SR offers a number of unique exterior and interior treatments, including sporty front and rear fascias and grille, dark headlight surrounds, fog lights, rear spoiler, suede seats and 16-inch sport aluminum-alloy wheels. The 2015 Versa Note SL features a range of special equipment, including NissanConnectSM with Mobile Apps, 5.0-inch color display, RearView Monitor, heated front seats, Divide-N-Hide® Adjustable Floor and 16-inch aluminum-alloy wheels.
In addition, the Versa Note S model receives new standard features such as Bluetooth® Hands-free Phone System. Versa Note's optional equipment packages also offer new or revised content for 2015.
The companion vehicle to the popular Versa sedan, Versa Note celebrates the unique qualities of its 5-door hatchback design. It shares its advanced platform and drivetrain with the Versa sedan, yet Versa Note has its own distinctive look and feel inside and out. Every 2015 Versa Note is equipped with an advanced 1.6-liter DOHC 4-cylinder engine with dual fuel injection and Twin CVTC (Continuously Variable Timing Control). The Versa Note S features a 5-speed manual transmission, while the S Plus, SV, SR and SL models are equipped with a standard next-generation Nissan Xtronic transmission.
A Bold Exterior Look – Open, Aero and
Nissan Versa Note's sculpted, modern styling is designed to accomplish two things: provide efficient aerodynamics to help enhance fuel economy and to stand out from the crowd of entry-level competitors. Its dramatic shape and proportions provide an energetic look that reflects the active lives of its target buyers. Along with its steeply sloped front windshield and deeply sculpted doors, Versa Note features a dramatic character line called the "squash line." Inspired by the international sport of squash, the line follows the trajectory of a squash ball hitting a wall, bouncing on the court floor and returning to the player. This "rebound path" projects the dynamic energy of Versa Note in both look and driving feel.
Attention to aerodynamic detail helps Versa Note achieve a coefficient of drag of 0.298 (Xtronic-equipped models) – a nine percent decrease over the previous generation Versa hatchback's 0.31 Cd. The large front spoiler combines with a "kick up" roof shape and low aero-drag floor structure (including front and rear tire deflectors, rear suspension beam mounted flush with floor and fuel tank deflectors) to direct airflow over, under and around the body.
Xtronic transmission-equipped Versa Note models include Nissan's first-ever Active Grille Shutter, which limits the amount of air entering the engine compartment, reducing drag force by 0.01. The Active Grille Shutter is generally closed at speeds above 20 miles per hour.
The iconic front grille and large multi-reflector headlights are paired with Note's "boomerang" rear taillights, which are similar to those found on the Nissan 370Z and Nissan JUKE. The special "vented" taillight design includes special outlets and lip to help guide air away from the body for reduced air turbulence and improved rear lamp visibility in bad weather. Fog lights and heated sideview mirrors are also available.
The new Versa Note SR model features unique SR front and rear fascias and grille, dark headlight treatment, body-color side sills, rear spoiler, sideview mirrors with integrated turn signals – providing a more sporty appearance. In addition, all models feature a new "Euro" design side rearview mirror shape for 2015.
Versa Note's dynamic design also takes full advantage of use of Nissan's global "V" platform. It features a long 102.4-inch wheelbase helping maximize interior roominess, while six-inch shorter front and rear overhangs than the previous Versa hatchback help provide a sporty stance and parking maneuverability.
The 2015 Versa Note is offered in eight exterior colors: Metallic Blue, Red Brick, Brilliant Silver, Magnetic Gray, Super Black, Aspen White and two colors – Metallic Peacock and MorningSky Blue – that that are designed to create an active, energetic presence and a clean, eco-friendly image respectively.
Roomy Interior, Segment-First Technology
The roomy interior is also a perfect match for the stylish Versa Note exterior. The five-passenger Versa Note cabin provides a spacious total interior volume of 112.9 cubic feet and ample cargo space of 18.8 cubic feet. Cargo area liftover height has been reduced by 1.7 inches (over previous generation Versa hatchback) for easier loading and unloading of heavy or bulky objects. The interior also offers front headroom of 40.8 inches and rear legroom of 38.3 inches – making Versa Note both kid friendly and adult comfortable.
Interior versatility is further enhanced through use of an available Divide-N-Hide® Adjustable Floor. With the standard 60/40-split fold-down rear seat folded down, a large flat cargo area is created. With the rear seats folded down, the Divide-N-Hide® system creates a flat cargo area.
Lifting up the cargo floor board reveals a hidden area underneath to keep valuables out of sight. When more space is needed for carrying taller or bulkier items, lowering the floor board creates a deeper cargo well. The floor board is designed to stay in the vehicle yet is easily removed if desired. It's a simple solution to balance the need for a flat load floor or maximum cargo capacity or security.
The long list of refined interior features starts with the standard cloth seating, 4-way adjustable front bucket seats (S, S Plus) or 6-way seats (SV), Fine Vision instrumentation, AM/FM/CD/Aux-in audio system with 4 speakers, 12-volt power outlet, front door pockets with bottle holders, dual front and rear cupholders, front seatback pockets and many more amenities.
Heated front seats with upgraded seat cloth and stitching are also available, along with leather-wrapped steering wheel, chrome/silver accents, USB input with iPod® control and steering wheel-mounted audio and Bluetooth® controls. The new Versa Note SR includes sporty suede seat accents and a 370Z-style steering wheel. Two interior colors are offered: Charcoal and Wheat Stone.
Among the 2015 Versa Note's unexpected and affordable technology is the class-exclusive* availability of Nissan's advanced Around View® Monitor. The system utilizes four small superwide-angle cameras mounted on the front, side and rear of the vehicle to provide a virtual 360° view of objects around the vehicle, with selectable split-screen close-ups of the front, rear and curb views, helping the driver maneuver the car into tight spots. The Around View® Monitor is offered as part of the SL Tech Package.
Also available as part of the SL Tech Package is the advanced NissanConnectSM with Navigation and Mobile Apps with SiriusXM Traffic and SiriusXM Travel Link™ (SiriusXM subscription required, sold separately), Enhanced Voice Recognition for navigation and audio and a 5.8-inch color touch-screen display. The NissanConnectSM with Navigation System also provides warnings for curves, speed limit information and an eco route setting.
The Hands-Free Text Messaging Assistant – which is also available with the NissanConnectSM with Mobile Apps as part of the SV and SR Convenience Packages – allows drivers to receive and respond to text messages without touching their cell phones. With a touch of a button messages can be read to the driver and answered with pre-loaded responses via voice recognition.
Other available Versa Note technology includes Nissan Intelligent Key® with Push Button Ignition, RearView Monitor and SiriusXM Satellite Radio (SiriusXM subscription required, sold separately) and standard Bluetooth® Hands-free Phone System.
The Right Combination of Power and MPG
With entry-level buyers looking for value not just in the initial purchase price but also in day-to-day operation, the 2015 Versa Note is designed to provide the perfect combination of fuel economy and performance.
Anchoring the front-wheel drive Versa Note is a 1.6-liter HR16DE 4-cylinder engine rated at 109 horsepower @ 6,000 rpm and 107 lb-ft of torque @ 4,400 rpm. The engine includes a range of cutting-edge technologies, including a dual fuel injector system that allows a wider injection of fuel (versus traditional single injector systems), with the smaller nozzles delivering a spray approximately 57 percent finer than the previous generation single injector design's particle size to help achieve more complete combustion.
The compact, lightweight engine also utilizes a Twin Continuously Variable Timing Control (CVTC) system mounted on intake and exhaust ports (versus conventional CVTC systems, which are mounted only on the intake port), similar to the system used on the flagship Nissan Maxima. Using a CVTC on the outlet port increases thermal efficiency, decreases inhalation resistance and offers an approximate four percent improvement in fuel efficiency (over the previous engine design).
Versa Note is offered with a choice of two transmissions – a 5-speed manual transmission (S model only) or a next-generation Xtronic transmission. The Xtronic transmission allows continuous change of the transmission gear ratio by connecting the two pulleys with a metallic belt and changing their diameter by using hydraulic pressure.
Aiding efficiency is an integrated auxiliary gearbox using planetary gearing. The Xtronic features a transmission ratio of 7.3:1, broader than those of typical 7-speed automatic transmissions. A transmission oil warmer transfers engine coolant heat to the transmission oil, helping reduce transmission friction during cold starts, increasing short trip fuel economy.
In addition to the advanced engine and transmission designs, excellent everyday drivability is provided by an independent strut front suspension with stabilizer bar, torsion beam rear axle with integrated stabilizer bar, and electric power steering. Braking is provided by standard power-assisted front disc/rear drum brakes with standard Anti-lock Braking System (ABS) with Electronic Brake force Distribution (EBD) and Brake Assist.
The 2015 Versa Note rides on standard 15-inch steel wheels with full wheel covers and 185/65HR15 all-season tires, while 16-inch aluminum-alloy wheels with 195/55HR16 all-season tires are standard with the SR and SL grades. Low rolling resistance tires are standard on all models.
Standard safety and security systems include the Nissan Advanced Air Bag System (AABS) (includes dual-stage front supplemental air bags), front seat-mounted side-impact supplemental air bags, roof-mounted curtain side-impact supplemental air bags, Vehicle Dynamic Control (VDC), Traction Control System (TCS) and Tire Pressure Monitoring System (TPMS) with available Easy-Fill Tire Alert.
A Range of Five Well-Equipped Grade Levels
The refined 2015 Versa Note is offered S, S Plus, SV and new SR and SL grade levels. In addition to the long list of standard features found on the Versa Note S with manual transmission, the Versa Note S Plus adds Xtronic transmission, transmission position indicator and Active Grille Shutter.
Versa Note SV models include power windows with one-touch down feature, power door locks with speed-sensing auto-lock, Remote Keyless Entry, cruise control, leather-wrapped steering wheel, chrome and silver interior accents, Piano Black C-cluster surround, new 3-dial Fine Vision Meter design, multi-function trip computer with outside temperature display, map light with key-linked illuminated entry system, driver's seat armrest, upgraded seat cloth and stitching, driver's seat lifter, USB input with iPod® control and more.
The new Versa Note SR adds the previously mentioned unique sporty exterior treatments, suede seat accents, variable intermittent front wipers, rear seat armrest with cupholders, SR badge, 16-inch aluminum-alloy wheels and more.
The new Versa Note SL includes NissanConnectSM with Mobile Apps, 5.0-inch color display, Streaming audio via Bluetooth®, Hands-free Text Messaging Assistant, SiriusXM Satellite Radio (SiriusXM subscription required, sold separately), RearView Monitor, center console with rear cupholders, heated front seats, Nissan Intelligent Key® with Push Button Ignition, Divide-N-Hide® Adjustable Floor Easy Fill Tire Alert, 16-inch aluminum-alloy wheels and SL badge.
Three equipment optional packages are offered: SV Convenience Package, SR Convenience Package and SL Tech Package.
The SV Convenience Package includes NissanConnectSM with Mobile Apps, 5.0-inch color display, Streaming audio via Bluetooth®, Hands-free Text Messaging Assistant, SiriusXM Satellite Radio (SiriusXM subscription required, sold separately), RearView Monitor, rear seat armrest with cupholders and Divide-N-Hide® Adjustable Floor.
The SR Convenience Package includes NissanConnectSM with Mobile Apps, 5.0-inch color display, Streaming audio via Bluetooth®, Hands-free Text Messaging Assistant, SiriusXM Satellite Radio (SiriusXM subscription required, sold separately), RearView Monitor and Divide-N-Hide® Adjustable Floor
The SL Tech Package includes NissanConnectSM with Navigation and Mobile Apps with 5.8-inch color touch-screen display, Enhanced Nissan Voice Recognition for audio and navigation, SiriusXM Traffic and SiriusXM Travel Link™ (fuel prices, weather, movie listings and stock info) (SiriusXM subscription required, sold separately), Around View® Monitor and heated sideview mirrors.
The 2015 Versa Note is assembled by Nissan Mexicana SA de CV in Aguascalientes, Mexico.
# # #
* AutoPacific segmentation. MY15 Versa Note v. 2014 Economy Compact Class, 5 passenger vehicles, excluding electrics and hybrids.


text:
Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma
Recruitment status was: Active, not recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Adult Alveolar Soft-part Sarcoma Adult Angiosarcoma Adult Epithelioid Sarcoma Adult Extraskeletal Chondrosarcoma Adult Extraskeletal Osteosarcoma Adult Fibrosarcoma Adult Leiomyosarcoma Adult Liposarcoma Adult Malignant Fibrous Histiocytoma Adult Malignant Hemangiopericytoma Adult Malignant Mesenchymoma Adult Neurofibrosarcoma Adult Synovial Sarcoma Childhood Alveolar Soft-part Sarcoma Childhood Angiosarcoma Childhood Epithelioid Sarcoma Childhood Fibrosarcoma Childhood Leiomyosarcoma Childhood Liposarcoma Childhood Malignant Mesenchymoma Childhood Neurofibrosarcoma Childhood Synovial Sarcoma Dermatofibrosarcoma Protuberans Metastatic Childhood Soft Tissue Sarcoma Nonmetastatic Childhood Soft Tissue Sarcoma Stage I Adult Soft Tissue Sarcoma Stage II Adult Soft Tissue Sarcoma Stage III Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma
|Drug: doxorubicin hydrochloride Other: clinical observation Procedure: therapeutic conventional surgery Radiation: 3-dimensional conformal radiation therapy Drug: ifosfamide
|Phase 3
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Risk-Based Treatment for Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) in Patients Under 30 Years of Age
- Long-term survival for low-risk patients [ Time Frame: Up to 5 years ]A monitoring boundary located in some sense halfway between the O'Brien-Fleming and Pocock group sequential boundaries to monitor against the expected experience will be used. A procedure adapted from Woolson will be used.
- Event-free and overall survival for patients in the intermediate risk group [ Time Frame: Up to 5 years ]Because the planned therapy for these patients (ifosfamide/doxorubicin chemotherapy and radiotherapy) is presently considered a standard of care, no formal monitoring of event-free or overall survival of these patients is planned.
- Local failure rate [ Time Frame: Up to 5 years follow up ]The method of Woolson103 to assess evidence for an unacceptable isolated local failure rate will be used. Evaluation of the isolated local failure rate will take place after 15, 30, and 45 isolated local failures are observed using monitoring p-values of 0.023, 0.052, and 0.070.
- Toxicity of neoadjuvant chemoradiotherapy [ Time Frame: Until week 13 ]A monitoring boundary located halfway between the O'Brien-Fleming and Pocock group sequential boundaries and a spending function approach will be used for interim monitoring of toxicity.
|Study Start Date:
|February 2007
|Estimated Primary Completion Date:
|September 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Group 1 (Observation or radiotherapy)
Patients with low-grade tumor with either negative or positive microscopic margins or high-grade tumor ≤ 5 cm (in maximum diameter) with negative microscopic margins are assigned to regimen A. Patients with high-grade tumor ≤ 5 cm (in maximum diameter) with positive microscopic margins are assigned to regimen B.
REGIMEN A (observation only): Patients undergo observation only.
REGIMEN B (adjuvant radiotherapy): Beginning between 6-42 days after surgical resection, patients undergo a total of 31 fractions of adjuvant radiotherapy.
Other: clinical observation
Patients undergo observation
Other Name: observationProcedure: therapeutic conventional surgery
Patients undergo surgeryRadiation: 3-dimensional conformal radiation therapy
Patients undergo radiotherapy
Other Names:
Experimental: Group 2 (chemotherapy, radiotherapy, surgery)
REGIMEN C (adjuvant chemoradiotherapy): Patients receive ifosfamide IV; doxorubicin hydrochloride IV; beginning in week 4, patients also undergo a total of 31 fractions of radiotherapy.
REGIMEN D (neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy with or without radiotherapy): Neoadjuvant chemoradiotherapy and surgery: Patients receive ifosfamide IV; doxorubicin hydrochloride IV. Beginning in week 4, patients also undergo a total of 31 fractions of radiotherapy. Patients undergo surgical resection in week 13.
Adjuvant chemotherapy with or without radiotherapy: Patients receive ifosfamide IV and doxorubicin IV. Beginning in week 16, some patients undergo a total of 6 fractions of adjuvant radiotherapy and some patients undergo a total of 11 fractions of adjuvant radiotherapy. Patients achieving total gross resection with negative microscopic margins do not receive adjuvant radiotherapy
Drug: doxorubicin hydrochloride
Given IV
Other Names:Procedure: therapeutic conventional surgery
Patients undergo surgeryRadiation: 3-dimensional conformal radiation therapy
Patients undergo radiotherapy
Other Names:Drug: ifosfamide
Given IV
Other Names:
Experimental: Group 3 (observation, chemotherapy, radiotherapy, surgery)
(High risk [metastatic, resected, incompletely resected, or unresected disease]): Patients with low-grade, all-sites resected tumor with either negative or positive microscopic margins are assigned to receive treatment as in group 1 regimen A. Patients with high-grade, grossly resected primary tumor, with metastases are assigned to receive treatment as in group 2 regimen C. Patients with unresected, high-grade metastatic tumor are assigned to receive treatment as in group 2 regimen D.
Drug: doxorubicin hydrochloride
Given IV
Other Names:Other: clinical observation
Patients undergo observation
Other Name: observationProcedure: therapeutic conventional surgery
Patients undergo surgeryRadiation: 3-dimensional conformal radiation therapy
Patients undergo radiotherapy
Other Names:Drug: ifosfamide
Given IV
Other Names:
Show Detailed Description
|Ages Eligible for Study:
|up to 29 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Newly diagnosed non-rhabdomyosarcoma soft tissue sarcoma (STS), confirmed by central pathology review via concurrent enrollment on protocol COG-D9902
- Metastatic or non metastatic disease
Meets 1 of the following criteria:
Intermediate (i.e., rarely metastasizing) or malignant STS, including any of the following:
Adipocytic tumor, including liposarcoma of any of the following histology subtypes:
- Dedifferentiated
- Myxoid
- Round cell
- Pleomorphic type
- Mixed-type
- Not otherwise specified (NOS)
Fibroblastic/myofibroblastic tumors, including any of the following:
- Solitary fibrous tumor
- Hemangiopericytoma
- Low-grade myofibroblastic sarcoma
- Myxoinflammatory fibroblastic sarcoma
- Adult fibrosarcoma*
- Myxofibrosarcoma
- Low-grade fibromyxoid sarcoma or hyalinizing spindle-cell tumor
- Sclerosing epithelioid fibrosarcoma
So-called fibrohistiocytic tumors, including any of the following:
- Plexiform fibrohistiocytic tumor
- Giant cell tumor of soft tissues
- Pleomorphic malignant fibrous histiocytoma (MFH)/undifferentiated pleomorphic sarcoma
- Giant cell MFH/undifferentiated pleomorphic sarcoma with giant cells
- Inflammatory MFH/undifferentiated pleomorphic sarcoma with prominent inflammation
- Smooth muscle tumor (leiomyosarcoma)
- Pericytic [perivascular] tumor (malignant glomus tumor or glomangiosarcoma)
- Vascular tumor, including angiosarcoma
Chondro-osseous tumors of any of the following types:
- Mesenchymal chondrosarcoma
- Extraskeletal osteosarcoma
Tumors of uncertain differentiation, including any of the following:
- Angiomatoid fibrous histiocytoma
- Ossifying fibromyxoid tumor
- Myoepithelioma/parachordoma
- Synovial sarcoma
- Epithelioid sarcoma
- Alveolar soft-part sarcoma
- Clear cell sarcoma of soft tissue
- Extraskeletal myxoid chondrosarcoma ("chordoid type")
- Malignant mesenchymoma
- Neoplasms with perivascular epithelioid cell differentiation (PEComa)
- Clear cell myomelanocytic tumor
- Intimal sarcoma
- Malignant peripheral nerve sheath tumor
Dermatofibrosarcoma protuberans meeting both of the following criteria:
- Non metastatic disease
- Tumor must be grossly resected prior to study enrollment
- Embryonal sarcoma of the liver
- Unclassified STS that is too undifferentiated to be placed in a specific pathologic category (undifferentiated STS or STS NOS)
Gross resection of the primary tumor ≤ 42 days prior to enrollment required except if any of the following circumstances apply:
- Non metastatic high-grade tumor > 5 cm in maximal diameter and gross or microscopic residual tumor is anticipated after resection
- Tumor of either high- or- low-grade that cannot be grossly excised without unacceptable morbidity
High-grade tumor with metastases
- Patients with metastatic low-grade tumor whose disease is amenable to gross resection at all sites must undergo gross resection of all sites prior to study entry
- Patients with a tumor recurrence after a gross total resection are not eligible
- Tumors arising in bone are not eligible
Patients with epithelioid sarcoma, clear cell sarcoma, or clinical or radiologic evidence of regional lymph node enlargement must undergo sentinel lymph node biopsies or lymph node sampling to confirm the status of regional lymph nodes* NOTE: *Except in cases where the study radiologist reviews the imaging and indicates that a biopsy is not needed to confirm that the patient has lymph node involvement.
- If lymph node biopsies are positive for tumor (or the lymph nodes are classified as positive by the study radiologist), formal lymph node dissection must be done at the time of definitive surgery(prior to study entry for patients assigned to study regimen C)
- Patients with metastatic disease must undergo a biopsy to confirm the presence of metastatic tumor if all metastases are < 1 cm in maximal diameter (except in cases where the study radiologist reviews the imaging and indicated that a biopsy is not needed to confirm that the patient has metastatic disease)
- Lansky performance status (PS) 50-100% (for patients ≤ 16 years of age) OR Karnofsky PS 50-100% (for patients > 16 years of age)
- Life expectancy ≥ 3 months
- Absolute neutrophil count ≥ 1,000/mm³*
- Platelet count ≥ 100,000/mm³*
Creatinine clearance or radioisotope glomerular filtration rate ≥ 70 mL/min (≥ 40 mL/min for infants < 1 year of age)* or serum creatinine based on age and/or gender as follows:
- 0.4 mg/dL (1 month to < 6 months of age)
- 0.5 mg/dL (6 months to < 1 year of age)
- 0.6 mg/dL (1 year to < 2 years of age)
- 0.8 mg/dL (2 years to < 6 years of age)
- 1.0 mg/dL (6 years to < 10 years of age)
- 1.2 mg/dL (10 years to < 13 years of age)
- 1.5 mg/dL (male) or 1.4 mg/dL (female) (13 years to < 16 years of age)
- 1.7 mg/dL (male) or 1.4 mg/dL (female) (≥ 16 years of age)
- Patients with urinary tract obstruction by tumor must meet the renal function criteria listed above AND must have unimpeded urinary flow established via decompression of the obstructed portion of the urinary tract
- Bilirubin ≤ 1.5 times upper limit of normal (ULN)*
- Shortening fraction ≥ 27% by echocardiogram* OR ejection fraction ≥ 50% by radionuclide angiogram*
Not pregnant or nursing (patients undergoing radiotherapy and/or chemotherapy)
- No nursing for ≥ 1 month after completion of study treatment in study regimens C or D
- Fertile patients must use effective contraception during and for ≥ 1 month after completion of study treatment
- Negative pregnancy test
- No evidence of dyspnea at rest*
- No exercise intolerance*
- Resting pulse oximetry reading > 94% on room air (for patients with respiratory symptoms)*
- Prior treatment for cancer allowed provided the patient meet the prior therapy requirements
- No prior anthracycline (e.g., doxorubicin or daunorubicin) or ifosfamide chemotherapy for patients enrolled on arm C or arm D
- No prior radiotherapy to tumor-involved sites
Please refer to this study by its ClinicalTrials.gov identifier: NCT00346164
Show 187 Study Locations
|Principal Investigator:
|Sheri Spunt, MD
|Children's Oncology Group
|Responsible Party:
|Children's Oncology Group
|ClinicalTrials.gov Identifier:
|NCT00346164 History of Changes
|Other Study ID Numbers:
NCI-2009-00426 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
COG-ARST0332 ( Other Identifier: Children's Oncology Group )
CDR0000483702 ( Other Identifier: Clinical Trials.gov )
U10CA098543 ( U.S. NIH Grant/Contract )
|Study First Received:
|June 28, 2006
|Last Updated:
|September 8, 2014
Additional relevant MeSH terms:
Sarcoma, Synovial
Sarcoma, Alveolar Soft Part
Histiocytoma, Benign Fibrous
Histiocytoma, Malignant Fibrous
Liver Neoplasms
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue
Neoplasms, Muscle Tissue
Neoplasms, Adipose Tissue
Neoplasms, Vascular Tissue
Neoplasms, Fibrous Tissue
Neoplasms, Complex and Mixed
Digestive System Neoplasms
Neoplasms by Site
ClinicalTrials.gov processed this record on September 21, 2017


text:
If you want to make a purchase while in Boston, there is select merchandise at the Market Stalls on the second floor of the Boston Design Center. Our booth at the Design Center has models, blueprints, paintings, lighting and other home decor and antiques for sale.
$ 375.00
$ 199.00
Early table lamp made from ship's block and tackle. Originally from Anthony's Pier 4 of Boston. Block is varnished, rope in good condition. Mounted to a round wooden base with...
$ 395.00
Size: 10 1/2" (with handle) x 7" x 6 1/2" (depth)Finish: Copper & Oxidized copperPeriod: 1920s (approximately)Manufacturer: Perko (Perkins Marine, Brooklyn USA)Polish: MatteLens: Fresnel, one marine blue, one red Detail:...
Sold Out
Size: 12" x 7" Finish: Brass Period: Early to Mid 19th Century Manufacturer: Perko (Perkins Marine, Brooklyn, NY, USA) Polish: Glossy Lens: Fresnel, one colored red, one green. Detail: -...
$ 495.00
Early Brass cabin lantern with glass globe, vented top and bottom, protective bars, carry handle and oil burner. 16 1/2" tall w/ handle.


text:
The Humboldt County Sheriff's Office seized hundreds of pounds of marijuana Friday during a follow-up investigation of a Eureka man arrested on Thursday.
Around 3 p.m. Friday, sheriff's deputies served a search warrant on Sabertooth Road on Titlow Hill, and discovered 93 growing marijuana plants ranging from 5 to 6 feet tall and several hundred pounds of dried marijuana, according to a press release.
Deputies contacted the property owner and his girlfriend, and released them for logistical reasons with the intent of seeking charges against them in the future, according to a press release.
After locating information about an address on Broken Wagon Lane, Westhaven, deputies served a search warrant on that address and found $21,000 and additional dried marijuana, according to a press release.
The investigation began on Thursday when deputies stopped a truck for a traffic violation around 7 p.m. and smelled marijuana around the vehicle, according to a press release. A search of the truck revealed about 10 pounds of processed marijuana and about $5,000 in cash.
Deputies arrested Eureka resident Linvell Williamson, 37, on suspicion of transporting and possessing marijuana for sale. He was booked into the Humboldt County jail on $25,000 bail, the release said.
A search warrant for Williamson's residence on the 3400 block of Donna Drive in Eureka was obtained. Deputies located 72 pounds of processed marijuana and about $4,000 cash.


text:
good luck dize
good luck dize
I'll take that kitten off your hands (i wish). Anyway, gl everyone!
Hello Kitty Island Adventure
I want it *.*
<3 Kitten <3
I can has kitteh, plz?
Here kitty kitty! I wants you right meow!
Come to mehhhh KittehhhhH! I will give you a nice and cosy home Lots of kitty love!
he a cinder kitten
I'm here hoping to win that pretty Kitten to match my burning feral RP druid
I extended the deadline until I closed the thread since I was a little late.
Winners have been PMed, please check your PMs!


text:
MALT Shovel A hosted leaders Cobblestones A in Division A of the Bridgwater Town Skittles League and, following a spare from Matt Gorvin, posted an opening hand of 61.
The visitors, without a spare, failed to beat the opening hand by a single pin but a Kevin Heritage spare in the second hand gave the team a 63. Shovel appeared to be struggling until a final man on spare from Steve Britton pulled a further seven to lead by eight.
Cobblestones showed why they are leaders over the following four hands, achieving a 15- pin swing, to enter the final hand seven up despite two 17 floppers from Darren Jeffreys of the Shovel.
The Malt Shovel's final hand of 76 set a target of 70 to win, which, without early spares, eluded the Cobblestones, who lost by six in a very evenly matched game.
In Division B, British Flag A crossed the town to play at the New Foresters, against the A team. A mighty 81 set the standard from the outset, netting the home side 13 pins, despite a 16 flopper from Keith Lott.
A better hand from the visitors in the second reduced the lead to two, before another winning hand switched the lead to the Flag and left the Foresters trailing.
Both teams struggled in the fourth hand, before another 80 hand saw the lead yet again switch. The penultimate hand went to the visitors as they hit an 80 of their own and leapt into the lead by 11.
Steve Bull's final hand 17 flopper set a target of 66 to win for the Flag. An early spare from Darren Kitch just wasn't big enough and the game ended a well-deserved draw.
Division C leaders West India A travelled to face the struggling Sydenham Centre A side. Sydenham started well with an opening spare from Phill Rowlands, followed by another mid-way through the hand by Mark Duddridge.
West India lost 18 on the opening hand and another 13 in the second after Sydenham hit two floppers and a spare to chalk up an 82.
West India showed grit and won the next four hands to leave Sydenham's impressive lead in tatters.
The final hand needed to be special if Sydenham were to claim the points needed to help extricate themselves from the relegation zone. The hand didn't disappoint, with two spares giving a target of 86 to win.
West India started perfectly with a spare from Sean Haysham, followed by a further spare from third player on Dean Henderson, however a triple of fives ruined the chances and Sydenham won by 19.
White Hart A visited the Bird in Hand to play their B team in Division D. Bird chalked up a 55 as an opening hand and started building their lead, another six pins were added in the second hand after a spare from Darren Selway led the home team to a score of 61.
The home side lost heavily in the fourth hand after White Hart's spares from Josh Harper and Phil Weller gave the visitors a game topping 76 to reduce the lead to three and another three pins lost in the sixth hand left the visitors only two behind.
Bird were not going down without a fight and posted a winning score of 75, within White Hart's range, but despite a good spare from Tom Harper the score proved elusive as they lost by six


text:
Burton ABS Vario 17L Cover
Our lightest and leanest backcountry pack built to pair seamlessly with the large ABS Vario Airbag Base Unit for industry-leading avalanche safety.
Setting the standard in backcountry performance and safety, the ABS Vario 17L Cover combines premier functionality with the leading avalanche airbag system. At a single pull of the handle, the ABS Vario base unit [sold separately] deploys twin airbags to help prevent or reduce depth of burial during an avalanche. Simply zip the pack cover onto the large ABS Vario Base Unit airbag for a seamless package that stores all your backcountry safety gear in a compact, lightweight design. Check out the 23L Pack version for a larger, more fully featured option that's ideal for longer, more gear-intensive missions.
- Compatible with Large ABS Avalanche Vario Base Unit [Sold Separately]
- Vertical Board Carry and Pack Compression System and Snowshoe Compatibility
- External Pole Storage with Ice Axe Loops
- Easy Access Internal Shovel and Probe Storage Pocket
- Goggle / Accessory Pocket
- Hydration Compatible
- Lifetime Warranty