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Tenofovir Disoproxil Fumarate to Treat Pediatric HIV
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- No Study Results Posted
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- How to Read a Study Record
This study will test the safety, side effects and antiviral activity of different doses of tenofovir DF in children and adolescents with human immunodeficiency virus (HIV) infection. Tenofovir DF belongs to a group of drugs called nucleotide analog reverse transcriptase inhibitors. These drugs prevent the virus from replicating (making more copies of itself).
HIV becomes resistant to many drugs used to fight the virus and these drugs become ineffective. In laboratory tests, tenofovir DF has remained effective against HIV longer than other anti-HIV medicines, and when resistance does develop, the virus may still be sensitive to other drugs.
HIV-infected children between the ages of 4 and 18 years who weigh at least 10 kg (22 pounds) may be eligible for this study. They must be able to receive antiretroviral therapy and have completed at least two previous antiretroviral courses of treatment without benefit.
Upon entering the study, participants will have physical, eye and neuropsychiatric examinations, blood tests, including tests to determine what anti-HIV drugs the patient is resistant to, an echocardiogram (echo), electrocardiogram (EKG), chest X-ray, head CT scan, skin tests, and special tests to examine the bones. These physical exams and tests will be repeated throughout the study to determine changes in health.
Participants will continue their current anti-HIV therapy for 2 weeks and then stop all medicines for a 1-week 'washout' period. After the washout period, patients will begin taking tenofovir DF. For the first 2 days on the drug, a small blood sample (1/2 teaspoon) will be collected 11 times over a 48-hour period through. A heparin lock (a tube kept in place in a vein) may be put in place to avoid multiple needle sticks. Blood samples will be collected for another 4 days to measure how well tenofovir DF alone works against HIV before other drugs are added to the treatment regimen. After these first 6 days, at least two other anti-HIV drugs will be added. They will be selected based on the results of the earlier blood tests for resistance and on the child's medication history.
After 3 days of combination therapy, patients will continue therapy on an outpatient basis. They will be seen in the clinic every 4 weeks at the start of the study and then every 12 weeks for physical exams, lab tests and other procedures as needed. The study will last approximately 48 weeks. Patients who benefit from therapy may be able to continue to receive tenofovir DF from the drug company sponsor or as part of another study, or the protocol for this study may be amended to lengthen the treatment period.
|HIV Infection
|Drug: Tenofovir DF
|Phase 1
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|A Phase I Study of Tenofovir Disoproxil Fumarate (PMPA Prodrug), A Novel Nucleotide Analog Reverse Transcriptase Inhibitor in Children With HIV Infection
|Estimated Enrollment:
|Study Start Date:
|October 2001
|Estimated Study Completion Date:
|September 2005
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
HIV-infected children between the ages of 4 years and less than 18 years.
BSA greater than or equal to 0.50 (m(2))
An indication for treatment with antiretrovirals as defined by the 2001 Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection (one of the following):
Clinical symptoms associated with HIV infection (i.e., clinical categories A, B, or C);
Evidence of immune suppression indicated by CD4 T-lymphocyte count or percentage (i.e., immune category 2 or 3);
High or increasing HIV RNA copy number;
Rapidly declining CD4 T-lymphocyte number or percentage to values approaching those indicative of moderate immune suppression (i.e., immune category 2).
Children failing at least their second antiretroviral regimen as defined by the 2001 Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection (http://www.hivatis.org/) (one of the following):
Less than a 10-fold decrease from baseline viral load in patients on a HAART regimen (combination regimen that includes a PI and/or NNRTI) after 8-12 weeks of therapy;
Less than a 5-fold decrease in viral load from baseline in patients on non-HAART regimen (e.g., dual NRTI combinations);
Viral load not suppressed to undetectable levels after 4-6 months of antiretroviral therapy;
Repeated detection of HIV RNA in patients who initially responded to antiretroviral therapy with undetectable levels;
An increase in viral load of greater than 3-fold;
Change in immunologic classification;
For children in immunologic category 3, a decline of five percentiles or more in CD4 cell percentage;
A greater than 30% decline in absolute CD4 cell count;
Progressive neurodevelopmental deterioration;
Disease progression;
Intolerant to or showing evidence of toxicity from other antiretroviral treatments.
HIV RNA greater than or equal to 10,000 copies/mL within the past 3 months (may be from outside institution);
Ability to swallow tablets.
Sexually active patients must be willing to use a medically acceptable form of birth control, which includes abstinence, while they are being treated on this study.
Hematologic function: Total WBC greater than 1,500/mm(3), Absolute Neutrophil Count greater than 750/mm(3), hemoglobin greater 8.0 gm/dL and platelet count greater than 75,000/mm(3) at study entry.
Hepatic function: Liver transaminases must be less than or equal 3.0 times the upper limit of normal; lipase less than 1.5 times the upper limit of normal; Creatinine phosphokinase (CPK) less than 2.5 times the upper limit of normal.
Renal function: patients must have an age-adjusted normal serum creatinine OR a creatinine clearance greater than or equal to 70 mL/min/1.73.
Informed Consent: All patients or one of their parents or legal guardians (if the patient is less than 18 years old) must sign the study informed consent to document their understanding of the investigational nature and the risks of the study before any protocol-related studies are performed.
Therapeutic regimens including:
- Nephrotoxic agents: aminoglycoside antibiotics, IV amphotericin B, cidofovir, cisplatin, foscarnet, IV pentamidine, oral and IV vancomycin, oral and IV ganciclovir;
- Immunomodulating agents (within 30 days of entry), other than GCSF, erythropoeitin, corticosteroids, IVIG, or anti-D;
- Treatment with chemotherapeutic agents (including hydroxyurea) or radiation therapy within the past 6 weeks; or
- Current use, or use within the last 28 days, of any investigational agent.
Clinically significant, unrelated systemic illness (serious infections or significant cardiac, pulmonary, hepatic or other organ dysfunction) which in the judgment of the Principal Investigator or Chairperson would compromise the patient's ability to tolerate this therapy or is likely to interfere with the study procedures or results
Weight less than 10 kg
Pregnant or breast feeding females will be excluded from this trial. Women of childbearing potential must be willing to agree to avoid becoming pregnant while on study and for 4 months afterwards.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00024986
|United States, Maryland
|National Cancer Institute (NCI)
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00024986 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 10, 2001
|Last Updated:
|March 3, 2008
Keywords provided by National Institutes of Health Clinical Center (CC):
Genotypic Resistance
Phenotypic Resistance
Immune Reconstitution
Bone Density
Pediatric HIV Infection
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
Reverse Transcriptase Inhibitors
Antiviral Agents
Anti-Infective Agents
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Anti-HIV Agents
ClinicalTrials.gov processed this record on September 21, 2017


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AT&T Boosts Wi-Fi and Mobile Network Coverage at the University of California, Berkeley
University of California, Berkeley AT&T Wi-Fi and Distributed Antenna Systems Provide Additional Wireless Capacity at UC Berkeley Campus
Berkeley, California, November 06, 2013
Students and faculty at the University of California, Berkeley now have access to improved AT&T Wi-Fi and mobile coverage across campus, including student residence halls, academic and administrative buildings.
The new Wi-Fi service allows on-campus wireless users to:
- Surf the web on smartphones and tablets, even in the hallway waiting for class to start
- Enjoy enhanced coverage on the campus-wide Air-Bears Wi-Fi system
- Easily connect smartphones and tablets without using their monthly data plans
"The University of California, Berkeley is a leader when it comes to integrating mobile technology to enhance the student experience," said Chris Roy, AT&T Vice President - Government and Education. "AT&T is excited to enhance the mobile experience for students, faculty and alumni when they are on the UC Berkeley campus."
The expanded Wi-Fi service will benefit the entire UC Berkeley community including visitors.
"Learning doesn't happen in one place, it happens everywhere," said Michael Green, UC Berkeley's Director of Telecommunications. "As a result of the expanded coverage, students will now have information at their fingertips across campus, enabling them to share ideas and resources with one another immediately."
To provide additional mobile capacity on campus, AT&T has installed a new Distributed Antenna System (DAS) as part of its three-year Velocity IP initiative. DAS uses antennas that are tuned to precisely match the area of a building where boosted service is needed. This technology improves call reliability, increases data traffic capacity and enables more consistent network access on campus. The DAS system will give students and faculty mobile connections when using their smartphones and tablets at Griffiths Hall and Etcheverry Hall.
"We have a long history of supporting higher education as well as providing services and products to help colleges and universities improve productivity both in and out of the classroom. Projects range from support of STEM scholarship programs and science/math focused summer camps for at-risk youth to hands-on technology labs and elite robotics competitions at the nation's leading universities - with nearly $87 million given to support STEM initiatives since 1995," said Terry Stenzel, AT&T Vice-President and General Manager of Northern California and Northern Nevada.
AT&T has also enhanced the customer experience at Memorial Stadium by deploying COWs (Cellular on Wheels). These mobile cell sites include a cellular tower and electronic radio receivers to help boost network capacity and performance. Football fans will enjoy better wireless coverage throughout the stadium on game days.
"Students no longer have to run to the rooftop to make a call," said Skyler Rojas, UC Berkeley's Co-Chair of the Student Technology Council. "Thanks to the network investment in our campus, we are now able to connect no matter what we are doing – whether that is cheering on the Cal Bears at Memorial Stadium or studying for finals at Griffiths Hall."
AT&T's Outstanding Network
AT&T has the nation's fastest and most reliable 4G LTE network according to independent third-party data.1 And AT&T's network performance continues to be validated by independent third-party testing:
- Our 4G LTE service was recognized as having faster average download and upload speeds than any of our competitors in PCWorld/TechHive's most recent 20-market speed tests – the second consecutive year that AT&T has ranked 1st overall. PCWorld/TechHive also ranked AT&T's as the fastest combination of 3G and 4G services in the 20 cities it tested.2
- And AT&T was named America's fastest 4G LTE network in PC Magazine's 2013 Fastest Mobile Networks 30-market study – and also swept the top rankings in all six U.S. regions from coast to coast: Northeast, Southeast, North-Central, South-Central, Northwest and Southwest.3
In addition, RootMetrics® has awarded AT&T for strongest overall call, text, and data performance in multiple markets in the most recent 2013 testing.4

subset: commoncrawl


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INDIANAPOLIS—Robert Griffin III reaffirmed Sunday that he will be one of the fastest quarterbacks in NFL history.
Griffin was unofficially timed at 4.38 seconds on his second attempt in the 40-yard dash Sunday at the Combine, after doing 4.41 seconds in his first attempt. Later in the day, officials announced his time as 4.41.
Scouts already knew Griffin was a speedster. He was one of the country's top hurdlers at Baylor before turning his attention strictly to football. However, Griffin's speed will bring a different dynamic to the quarterback position for any team that drafts him.
It's another dimension that gives Griffin at least a puncher's chance to be the No. 1 pick in the draft, if the Colts are keeping an open mind whether to chose Griffin or Andrew Luck.
Neither Griffin nor Luck will throw Sunday, but Griffin has made a splash at the Combine with his personality and physical talent. Griffin is likely making quarterback-needy teams like the Browns and Redskins think even harder about trading up to get him.
Janoris Jenkins tries to convince teams he's changed
Andrew Luck matches Cam Newton's 40 time
Impressive Kirk Cousins could enter first-round discussion
Michael Floyd helps draft status with 40 time
Virginia Tech's Danny Coale near perfect in route running
Case Keenum turns in disappointing throwing performance


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What a Difference a Month Makes
DKW; November 14, 2008
Yes and no. Spoken like a true economist. Let's review the recent history. U.S. GDP was revised going back six quarters and second quarter 2008 preliminary numbers were released at the end of August. In the revision, fourth quarter 2007 was marked down to a negative 0.2% (first negative quarter in six years). Second quarter 2008 registered a positive 3.3%. The jump in second quarter GDP is attributed to the stimulus package rebate checks, narrower trade deficit, and higher exports. Exports contributed the vast bulk of the growth. Real exports of goods and services increased 13.2% in the second quarter.
Jobs numbers are falling at a measured pace and unemployment rates are rising along with unemployment insurance claims, although not at the sharp rates usually associated with a bona fide recession. Industrial production and the manufacturers and non-manufacturers indexes are wandering back and forth around neutral. Financial and credit markets are still staring into the headlights. The housing market is still in the doldrums. Real residential fixed investment decreased 15.7% in the second quarter, housing inventories are at eleven months (5 months is desired), sales are down, and prices are at best slightly positive in some locales.
So what should we expect in the next few quarters? Let take each item going from back to front. The prospects for the housing market remain bleak. Not only are houses not selling, they continue to fall in price, further sapping incentive to honor mortgage commitments and pinching the cash flows that support the downstream investment bets. Mortgage credit standards have tightened, shutting out some prospective buyers. The Treasury takeover of Fannie Mae and Freddie Mac will do little besides shove another several billion dollars of liquidity into the market, hoping to buy enough time for the housing/mortgage/credit markets to work out of the funk. More financial institutions will be scavenging for white knights to rescue them from bankruptcy or total liquidation. Some won't make it.
The bulk of U.S. goods and services have been supported by foreign demand. First-half 2008 U.S. exports were up 18% versus year-ago. Wisconsin exports were up almost 14%, led by machinery, electrical machinery, and medical devices. With the European economies weakening and the dollar strengthening, exports are likely to diminish, eliminating one of the two remaining legs supporting a wobbly economic stool. Lower export production will displace more workers. Unemployment claims and rates should continue to rise. Continued unemployment insurance claims have ratcheted up to 2003 levels, the most recent highs coming out of the last recession. Wisconsin's unadjusted unemployment rate for August was a curiously low 4.7 percent.
The remaining leg of the economic stool is consumer spending. The stimulus package checks gave a shot in the arm to consumer budgets. However, higher gasoline and food prices absorbed much of the cash flow. Noteworthy is the spending patterns following the stimulus checks. Discounters benefited (Walmart and Costco). Electronics sales increased (computers and big screen TVs). There were some savings and debt reduction as well. The stimulus checks have now come and gone as have retailers' spirits, who yet dream of a plum holiday sales burst even though consumers have less home equity to tap and shaky job expectations to supply much seasonal shopping cheer.
GDP expectations for the next four quarters are not glowing. Projections are for a slow third quarter, slower fourth and first quarters, with hope for some growth in the second quarter of 2009. However, if the housing market hasn't bottomed out by then (housing is subtracting a percentage point from GDP; if housing would just stop falling, GDP would get a boost), and the credit markets aren't showing any light at the end of the tunnel, the economic lethargy could be protracted.
Inflation, running at nearly 5%, is expected to tame, although gasoline and food prices are not expected to drop substantially. The trick with inflation is that even if oil and food prices stay at high levels for a prolonged period, the high but constant prices no longer push inflation rates up. The higher costs do, however, impact consumer budgets and spending patterns. Still, if the inflation numbers drop, the Fed may lower interest rates to try to jump start the economy. As of this writing, the Fed decided to leave fed funds rates unchanged at 2 percent.
So, more of the same, yes and no.
Written by Dennis Winters, Chief Economist and OEA Administrator. September, 2008.


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Topic: New Member - sister in law, only 40 with cc
Hello All
My sister in law was recently diagnosed with terminal metastatic cc with turmour in the intrahepatic artery. The last 6 weeks have been a whirlwind and I am seeking advice from people who understand the symptoms to enable the family to better support her. I am in the UK.
She has just completed #2 Chemo (Gem/Cispl) and appears to be doing Ok so far. I would welcome advice/info from anybody who combined strict diet/ hemp oil with chemo treatment. I believe both science and alternative medicine have a role to play.
She had a drain last week for ascites and I wonder how often this is likely to occur? I have so many questions but don't want to ramble. I'm grateful this site exists - thank you all.


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Did you know Isaac saw Washington in the woods yesterday? The general was all alone, kneeling on the ground, his sword on one side and his cocked hat on the other. Isaac said he was crying out to the Almighty, beseeching him for divine aid. Isaac said he had never heard such a prayer from the lips of man. I, too, plead with the Lord to show his mercy, for the soldiers' anguish follows me like a shadow. How can I eat my soup when these wretched souls have nothing but fire-cakes and water? How can I sleep when there's such affliction at our door-step? Even in my dreams I see their wasted remains, huddled 'round a smoky fire, nearly naked without even a blanket to ward off the chill.
Oh, dear husband, I pray your patience for I feel your reproach each day when I go to visit them. You know I don't mean to bring discord into our home, but tis so cold outside… Have you ever asked yourself what cursed cause drove them to this valley of death? Could you imagine embracing a death of misery and starvation, forsaking the children and me for the idea of "liberty"?
For weeks I've had a lump in my throat each time I swallow my tea, knowing that just beyond the hill, one by one, the Continentals are perishing. It's pitiful, and if you must know the truth, I'm shocked at your disregard for their plight. They're abandoned, even by their own Congress, without so much as an axe to cut wood for their fires. Many are younger than our John. I wouldn't blame them for running away, but still, they stay and wait…
Yesterday a soldier wept and called me an angel of the Lord when I delivered a crust of bread and a few potatoes. As I walked home I wondered, does my charity help or only prolong their agony? I do not know, but of this I am certain: I am my brother's keeper, and in their filthy rags, they are someone's father, husband or son!
These boots? You know very well who they belonged to — my father. They've lain in the trunk for years. I know a young man who will lose both feet without them. I'm asking you once more to reconsider, for I swear, if you won't take them to him, I will!
Disown me. Put me aside if you must. But I say to you something of extraordinary importance is happening in these frozen fields of Valley Forge and our future is intertwined with the soldiers!
Wait! Wait! Before you turn away from me — today I spoke with a boy no older than 16 who lay dying. I couldn't hold back my tears as I held his hand and prayed over his gaunt body. As I said goodbye, he pulled a letter from his pocket and begged me to have it delivered. When I got home, I opened the letter to see what he had written. Please, open your heart, my husband. Listen to his words:
Dear Mother,
My letter comes with a heart full of fond remembrance. I look forward to the day I return home to help you carry the load, but for now, it is my duty to guard the flame of liberty. Always remember me to Abigail and my sisters, and do not fret, Mother, for we are living off the fat of the land.
Your dearest Son, Jacob.


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I'm trying to use an FAQ style method for initialing hiding then revealing answers to common questions.
A similar example can be seen on:Support | Springpad under the section Common Questions.
The problem is that when an item is revealed, by switching the elements style from "display:none" to "display:block", the screen reader will not read it.
Does anyone know if it is possible to use this UI device in an accessible way?
Many thanks!
Some screen readers will read something that has changed state, but many older ones won't, because they don't know they must update their buffer.
buffered screen readers, when they load the page, make a local copy (a buffer) which the user then interacts with.
In any case, without Javascript there is only one set of thingies on the right side. That is a mistake. The best method is to show ALL the information by default and let your menu on the left skip to the relevant information using the urlhash (like #common).
When users have Javascript, let Javascript do the hiding, instead of defaulting with CSS. Javascript hides and unhides the relevant areas.
And finally you can avoid the block/none problem by using another method of hiding non-relevant information from sighted users.One is to absolutely position the content offscreen. This "counts" as being on the screen as far as a screen reader is concerned, meaning that content will get loaded into the buffer. So instead of onclick making the section go from "none" to "block", you would instead change its "left" or "left-margin" property (usually I have Javascript add or remove a class which is pre-defined in CSS with these margins).

content...

Javascript, onload:
On the Orca mailing list I once heard people complaining about a web site where they would click but nothing would happen.
Turns out the site had h2's with onclick events (so the screen readers thought these were clickable things and read them out as links in this case, but they weren't links and could not be selected via keyboard) that were supposed to take divs underneath who were display: none by default and change them to display: block. A expansion script using either overflow or absolute positioning would have been much better (also using something natively clickable like an anchor would have also helped, and the content should not have been hidden also from those who don't have the Javascript to show it).
Of course, there had better be a really really good reason to hide stuff from people. Are you really increasing usability?You can always try the typical FAQ format.
Heh, love the way the targeted numbers get bigger. Very nice.
Heh, love the way the targeted numbers get bigger.
Not in IE.
But of course.
Works fine in Internet Explorer 9.
I was going to make much the same comment. I had to have a snoop at your CSS to see what you used and I've never seen :target used anywhere before, that I know of.
Places It's Tempting To Use Display: None; But Don't
You want to hide something on a page, so:
.hide {
display: none;
But wait! By applying that class to an element you've immediately made that content "inaccessible" by screen readers. You've probably known this forever, but still the poison apple sneaks into our code once in a while.
I don't want to re-hash all the specifics. Your best bet is to read "Now You See Me" by Aaron Gustafson on A List Apart to get an understanding of this if you don't already.
One way to encourage yourself to do the right thing is by creating more appropriate class names. Your regular hide class should position the content off screen, which still leaves it screen reader accessible:
.hide {
position: absolute !important;
top: -9999px !important;
left: -9999px !important;
I use !important here because if you've gone to the trouble to add a "hide" class to something, you probably mean it and don't want to think too hard about if the specificity value is strong enough. And if you know that you need to display: none something, the class should help you understand it:
.remember-this-will-NOT-be-read {
display: none !important;
OK you got it. Easy peasy when you're totally in control of class names and all you do is apply and remove them. But things get a little tricker with JS libraries that apply their own CSS. For instance in jQuery, after you .slideUp(), you'll have a display: none in the inline CSS to deal with. Yes, screen readers run JavaScript and yes, that's still a problem.
Again Aaron Gustafson has us covered there, who suggests applying the accessible class name after the sliding is done and then removing the display: none by sliding it the other direction.
var $button = $('#myButton'),
$text = $('#myText'),
visible = true;
$button.click(function() {
if (visible) {
$text.slideUp('fast',function() {
} else {
$text.slideUp(0,function() {
visible = !visible;
Original article is posted by ChrisCoyier : http://css-tricks.com/places-its-tempting-to-use-display-none-but-dont/
I have nothing to add to this thread. Just wanted to mention that I really like that FAQ look that Stomme posted. =p
Actually, I lied.
To elaborate on the overflow:hidden method. This would be an especially handy method for this implementation. If you wanted to do an effect (like a slideDown), you can easily do that by leaving it overflow:hidden and increasing it's height (the basic approach jQuery uses). The absolute positioned one can do it as well, but the "logic" behind it is a bit weird to me (you have to make it small, then move it back, then make it grow, etc).
Just be careful if you use things like jQuery's slideUp, because it sets display: none to the element at the end, so you'd want to remove that when it was done.
To me it's a sign of bad CSS, except later you mention jQuery and often (unfortunately) the common use patterns for jQuery and many of the plugins people use add in inline CSS, which can only be overridden with !important. Still, I hate it. My user stylesheet needs !important to override bad author stylesheets.Also, unless Window-Eyes fixed their bug (maybe they did, this was like version 5 or something), don't use top: -9999px. Left will do.
I used to use em's for off-screen, like left: -9999em. This was very very bad for Opera and Konqueror. Konq would wrap around to the right. Opera did something else, I forgot. Doing the same for top: -9999em made Opera cut the page short. Turns out Opera has a pixel limit on widths and heights, something like 32000px (found by Erik J). So now it's -999em, or if it needs to come onscreen on :focus I noticed em's didn't work at all with keyboard so back to -9999px I went. Sigh.
How about we go to jQuery.com with pitchforks and torches and demand an end to the display: none junk?
It wouldn't be a bad idea. I want to get my team to stop using display: none as well, so I've been thinking of downsides or special cases when it is required or when a large negative margin wouldn't work, but I can't really think of anything. It seems pretty easy to just drop it in place, then flip back to position: static when you need to move it back.
Sometimes having it positioned doesn't work in a setup, I suppose... but then I'd fall back to overflow then...


text:
A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Drug: Saracatinib Drug: Placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Cross-over, Phase II.5 Study of Saracatinib (AZD0530), a Selective Src Kinase Inhibitor, In Patients With Recurrent Osteosarcoma Localized to the Lung
- To determine the progression free survival rate among patients treated with Saracatinib and placebo. [ Time Frame: Evaluation for recurrence/progression will be made every 3 months for the 1st year, then every 6 months up to 2 years, then every year up to 5 years after starting treatment. ]
|Estimated Enrollment:
|Study Start Date:
|March 2009
|Estimated Study Completion Date:
|May 2017
|Estimated Primary Completion Date:
|May 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Active Comparator: 1
Drug: Saracatinib
Oral Agent
|Placebo Comparator: 2
Drug: Placebo
Oral Agent
Detailed Description:
Further details provided by SARC (Sarcoma Alliance for Research through Collaboration):
After complete surgical removal of their cancer, patients will be randomly assigned to receive either Saracatinib or placebo (a sugar pill) throughout the study. Patients will take Saracatinib (or placebo) once daily by mouth for a total of 364 days. The duration of treatment is divided into 13 cycles, 28 days each cycle with no breaks in between.
Patients will be seen for interim medical history, physical exam and laboratory studies prior to each cycle. To monitor for recurrence of tumor, patients will undergo thoracic CT scans at 3-4 weeks, 6-8 weeks, at 3 months, at 6 months, at 9 months, at 12 months, then every 6 months up to 2 years, and then every year up to 5 years after starting treatment. An electrocardiogram (ECG) will be taken at 3 months, and a bone scan will be performed at 12 months.
Patients who recur in the lung while on-study and who are thought to be amenable to complete surgical resection will be able to find out if they were receiving placebo or saracatinib. Those patients who were receiving placebo may then have the option of undergoing surgical resection. If fully resected of all recurrent disease,they will be given the option of receiving oral therapy with saracatinib. Saracatinib will be administered as a once daily, oral dose of 175 mg, for a 28-day cycle, with no breaks between cycles. The duration of treatment with saracatinib will be thirteen 28-day cycles (364 days total). If complete resection of all lung nodules is not achieved, the patient will be removed from the study.
Patients who recur in locations other than the lung while on-study will be taken off study at that time.
Blood and tumor samples for research purposes will be collected at the time the tumor is removed.
After completing all 13 cycles, patients will be followed for approximately every 3 months until 2 years from starting treatment, then approximately every 6 months until 4 years from starting treatment, and once at year 5.
|Ages Eligible for Study:
|15 Years to 74 Years (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patient had recurrence of osteosarcoma, localized to the lungs, had complete surgical removal of all lung nodules are eligible for enrollment.
- Patient with suspected recurrence of osteosarcoma but who has not had surgery is eligible for enrollment but will not be randomized to receive study medication until deemed fully eligible following surgical removal of all lung nodules.
- Patient had histological confirmed diagnosis of osteosarcoma of the recurrent sample.
- Patient had recurrence of osteosarcoma in the lung following standard therapy including: adriamycin, cisplatin, ifosfamide and methotrexate.
- Patient is ≥ 15 and < 75 years of age.
- Weight ≥ 34 kg.
- ECOG performance score of 0-2.
- Adequate bone marrow function.
- Adequate renal function.
- Adequate hepatic function.
- Adequate cardiac function.
- Women of childbearing potential must have had a negative pregnancy test (urine or serum) ≤ 7 days prior to enrollment, and willingness to use an acceptable method of contraception during participation in the study and for 3 months after the last dose.
- Randomization must occur ≤ 6 weeks after complete surgical resection.
- Patient or legal guardian has signed informed consent.
Exclusion Criteria:
- Presence of metastatic disease in other locations in addition to the lung.
- Disruption of the lung pleura by tumor.
- Paget's disease.
- Patient currently using, or has previously used CYP3A4 inducers or inhibitors within 2 to 14 days prior to the initiation of oral therapy.
- Known hypersensitivity to other Src/Abl non-receptor kinase inhibitors.
- Evidence of interstitial lung disease.
- Any concurrent condition which in the investigator's opinion makes it undesirable for the patient to participate in the trial or which would jeopardize compliance with the protocol.
- Myocardial infarction within one year prior to study entry.
- Bleeding diathesis, resulting in symptomatic bleeding.
- Patient is pregnant or nursing/breast-feeding.
- Patient received chemotherapy, biological or investigational agent ≤ 28 days prior to enrollment.
- Patient experiencing unresolved toxicity ≥ CTCAE grade 2 (except alopecia) from previous agents.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00752206
|United States, Alabama
|University of Alabama
|Birmingham, Alabama, United States, 35233
|United States, California
|Children's Hospital Los Angeles
|Los Angeles, California, United States, 90027
|USC/Norris Comprehensive Cancer Center and Hospital
|Los Angeles, California, United States, 90089
|UCLA/Mattel's Children's Hospital
|Los Angeles, California, United States, 90095
|Stanford University
|Palo Alto, California, United States, 94304
|San Francisco, California, United States, 94143
|Sarcoma Oncology Center
|Santa Monica, California, United States, 90403
|United States, Florida
|University of Florida
|Gainesville, Florida, United States, 32610
|University of Miami
|Miami, Florida, United States
|United States, Indiana
|Indiana University
|Indianapolis, Indiana, United States, 46202
|United States, Iowa
|University of Iowa Hospitals and Clinics
|Iowa City, Iowa, United States, 52242
|United States, Maryland
|Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
|Baltimore, Maryland, United States, 21231
|National Cancer Institute
|Bethesda, Maryland, United States, 20892
|United States, Massachusetts
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02115
|United States, Michigan
|University of Michigan
|Ann Arbor, Michigan, United States, 48106
|United States, Ohio
|Cincinnati Children's Hospital Medical Center
|Cincinnati, Ohio, United States, 45229
|United States, Tennessee
|St. Jude Children's Research Hospital
|Memphis, Tennessee, United States, 38105
|United States, Washington
|Seattle Cancer Care Alliance/University of Washington Medical Center
|Seattle, Washington, United States, 98109
|Principal Investigator:
|Kristin Baird, MD
|National Cancer Institute - Pediatric Oncology Branch
Additional Information:
|Responsible Party:
|Sarcoma Alliance for Research through Collaboration
|ClinicalTrials.gov Identifier:
|NCT00752206 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|September 11, 2008
|Last Updated:
|March 20, 2017
Keywords provided by Sarcoma Alliance for Research through Collaboration:
to the Lung
Additional relevant MeSH terms:
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Antineoplastic Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017


text:
Started this discussion. Last reply by Jim Tetterton Aug 7, 2012. 13 Replies 0 Likes
I have a passion for old cars (primarily pre-1972 Chevys, Corvettes, and Jeeps) and have bought and sold a few cars per year over the past 15 years. I find myself almost "addicted" to searching for…Continue
Tags: distraction, purpose, christ, passion, cars
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Very little work has gone on along the Highway 101 bypass route around Willits this past week; newly arriving birds have held center stage.
For unknown reasons, CalTrans delayed the start of the tree and vegetation removal until after the birds began to arrive. The protection of migratory bird nesting sites is not a new or specialized requirement designed specifically for the Willits bypass project.
CalTrans was well aware it needed to remove or cut down vegetation from the bypass work area before the migratory birds began to arrive. CalTrans has known for decades that starting the removal in the dead of winter is optimal.
By failing to act in a timely manner, it is CalTrans, not protestors, that has placed the timely start of the bypass project in jeopardy. The monitoring by the protestors did call attention to possible nesting activity so the appropriate agency, in this instance the Department of Fish and Wildlife could step in. CalTrans also had the responsibility to monitor and act in defense of the nesting birds.
CalTrans believes it has received approval from the Department of Fish and Wildlife on its revised process or protocol for spotting and monitoring nesting bird activity along the construction corridor, according to CalTrans spokesman Phil Frisbie. According to Naomi Wagner of Earth First!, Frisbie told her CalTrans expected to return to the job site Thursday to conduct these new surveys.
What the new survey protocols are, and how they differ from the earlier biological survey protocols, was not available at press time.
The presence of any bird nest along the construction corridor will require CalTrans to mark the offending nest location and to cordon the area off to prevent disturbance until the young birds have hatched and flown away.
Wagner is concerned CalTrans biologists may not be sufficiently diligent to prevent a disruption of the nesting activity, and promises concerned citizens will be monitoring the situation


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Fowler's walk-off ensures comeback isn't wasted
Rockies take Dodgers to extras again, winning this time in 10
DENVER -- Just when Saturday afternoon's matchup with the Dodgers looked like a familiar tale of comeback followed by heartbreak for the Rockies, Dexter Fowler made sure it would not be a repeat of Friday night.
Fowler roped a walk-off, 10th-inning single inside the first-base line to easily score Yorvit Torrealba and give the Rockies a redemptive 7-6 victory at Coors Field. Two catchers -- Torrealba and pinch-hitter Wilin Rosario -- singled to set up Fowler's winning hit on a curveball high in the zone off Dodgers reliever Matt Guerrier (1-2).
The victory ended a three-game slide and kept the Rockies from falling to .500 for the first time since April 2, their second game of the season. Colorado has dropped six of its past nine.
"I was really worried," left fielder Carlos Gonzalez said. "Every time it seems like we come back, but it's been tough for us to get the big hit, and really excited to see Dexter getting the big hit, and most important, getting the 'W.'"
Before Fowler stepped to the plate, Rosario extended the inning when he hit a soft grounder and raced down the first-base line to barely beat out a throw from Dodgers shortstop Nick Punto. With two out already, it kept the rally alive and saved the Rockies from going to the 11th.
"It's a hustle play right there, extended the inning," Rockies manager Walt Weiss said. "You don't see [Rosario] getting a lot of infield hits, but he actually runs pretty well for a catcher. He got out of the box well, and that's a huge play."
But the rally never would have been possible without two outstanding defensive plays from Gonzalez, who finished 2-for-5 with a two-run homer.
In the third, a single to left from Jerry Hairston scored Scott Van Syke and gave the Dodgers a 3-0 lead. When Mark Ellis tried to score from second, Gonzalez gunned him down with a spot-on throw to Torrealba, who quickly controlled the ball and tagged Ellis as he slid into home plate. Los Angeles did not score again in that inning.
In the fourth, Gonzalez sprinted toward shallow left-center field and laid out to snag a Punto pop-up, allowing Rockies starter Jhoulys Chacin to escape with a 1-2-3 inning.
"I always try to help my pitchers," Gonzalez said. "It seems like little things, but at the end of the game, that's a big difference. I saved a run and possibly another rally when I made the diving catch."
Fowler's walk-off made a winner of Matt Belisle (3-2), who pitched a scoreless 10th. With closer Rafael Betancourt headed for the 15-day disabled list Sunday, Rex Brothers pitched a scoreless ninth ahead of Belisle.
It was set up by a two-run Michael Cuddyer homer in the seventh that knotted the score at 6 and ultimately forced extra innings for the second time in as many games, answering the Dodgers' two-run sixth.
Colorado first re-claimed a lead in the fifth inning, when Gonzalez lifted the first pitch he saw into the first row of the left-field seats to put the Rockies ahead, 4-3. Gonzalez's 14th homer of the season came with Fowler on base after the center fielder hit an RBI single, scoring Torreabla.
"It was definitely a good game," Cuddyer said. "It was a game that we needed to win, not because our season would have ended if we'd lost, but we needed to get our minds in a good place. A win like that hopefully will be able to do that and give us some momentum going into tomorrow."
Gonzalez's two-run homer interrupted an effective outing from Dodgers starter Zack Greinke, who gave up four earned runs, three walks and struck out three in 5 1/3 innings.
"I haven't pitched well a whole lot this year," said Greinke, who had surgery on a fractured left collarbone in April. "I expected to do better the first couple of outings than I have. I've got to make the adjustments and pitch better."
Chacin's toughest out came from a surprising bat -- that of Dodgers' catcher Tim Federowicz. Federowicz entered the game hitting .136, but sent a hanging Chacin slider over the left-field wall in the third. It was the first home run of his 23-game career.
Federowicz then dropped a double into a gap in left-center to drive in two more runs in the sixth and erase the Rockies' brief lead. The two previous batters, Skip Schumaker and Punto, sprayed the ball into the outfield for singles, and Federowicz wasted no time picking up his second and third RBIs of the year.
Lefty Josh Outman took over for Chacin in the seventh and quickly recorded two outs before Weiss replaced him with right-hander Edgmer Escalona. Escalona surrendered a double to the first batter he faced, Hairston. Four pitches later, a Schumaker single to center scored Hairston and handed the Dodgers a 6-4 lead.
Productive fifth and seventh innings for Colorado ended the offensive frustration that plagued the Rockies through much of the week. Cuddyer and Todd Helton reached base with consecutive singles in the second before third baseman Nolan Arenado doubled into the right-field corner for Colorado's first run.
Ian McCue is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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General News of Thursday, 22 November 2012
Source: myjoyonline
The Presidential Candidate of the opposition New Patriotic Party, Nana Akufo-Addo has mounted arguably the most robust defence yet of his free senior high school promise.
Answering a question on how to use the country's oil resources for the benefit of the people, Nana Akufo-Addo said his commitment to the free SHS policy was not about winning the December elections but about preparing the country's next generation.
"Clearly the most equitable manner in which our nation and our people would benefit from the oil revenue is to ensure that they are used on the two most critical aspects of our national life – our education and our health care," he said.
"If at the time the oil resources run out...," Nana Akufo-Addo explained, "we have a transformed Ghanaian population – educated – which has access to good healthcare, we now have the basis to sustain the development of our nation; not for one year, not for two years but for generations to come."


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South Dakota's Senate Bill 55 passed the Senate Education Committee on a 4-3 vote on January 24, 2017, despite the opposition of the state's educational communities, according to the Sioux Falls Argus-Leader (January 24, 2017).
Indiana's Senate Resolution 17, introduced and referred to the Senate Committee on Education and Career Development as of January 23, 2017, would, if adopted, ostensibly urge the state department of education "to reinforce support of teachers who choose to teach a diverse curriculum." But the teaching of evolution is the specific target of the bill.
A draft of a new national curriculum in Turkey omits evolution, according to soL international (January 15, 2017).
Senate Bill 393 (PDF), styled the Oklahoma Science Education Act, is the latest antievolution bill in the Sooner State.
National Center for Science Education, Inc.
1904 Franklin Street, Suite 600
Oakland, CA 94612
fax: 510-788-7971
For Reporters | Store | Events


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The poster "pacertom" since this forum began (and before!). I changed my name here to "Slick Pinkham" in honor of the imaginary player That Bobby "Slick" Leonard picked late in the 1971 ABA draft (true story!).
Lots of good ones. The Packers is brilliant, but the Chiefs is probably funniest.
Well, Mike Shanahan looks about right in the Redskins logo.
Good stuff.
Why do the things that we treasure most, slip away in time
Till to the music we grow deaf, to God's beauty blind
Why do the things that connect us slowly pull us apart?
Till we fall away in our own darkness, a stranger to our own hearts
And life itself, rushing over me
Life itself, the wind in black elms,
Life itself in your heart and in your eyes, I can't make it without you
Colts one is so true.
Vikings one is pretty funny.
haha very clever. Definitely some good ones there
I love the colts one!
Larry Bird and Ryan Grigson- wasting the talents of Paul George and Andrew Luck


text:
Options and Accessories (View All)
Marketing Information
Tripp Lite EZ-series SU16KRTG 16,000VA / 16kVA / 14,400 watt online, double-conversion UPS system offers complete power protection for critical server, network and telecommunications equipment in a 12U rack/tower configuration. This system delivers complete N+1 redundancy when used at loads up to 8kVA, and non-redundant operation at loads between 8 and 16kVA. Fault-tolerant auto-bypass prevents unexpected service interruptions during UPS overload or internal fault conditions. Included parallel PDU with manual bypass switching enables hot-swappable replacement of all major UPS system components in both N+1 and combined operating modes. Enhanced availability, fault tolerance and simple hot-swap replacement options make this UPS ideal for advanced networking applications in data centers, computer rooms, network closets and rugged industrial locations.
General Information
|Product Type
|Dual Conversion Online UPS
|Manufacturer Part Number
|Manufacturer Website Address
|Tripp Lite
|Product Model
|Product Name
|SmartOnline EZ SU16KRTG 16kVA Tower/Rack Mountable UPS
|Product Line
|Product Series
|Brand Name
|Tripp Lite
Technical Information
|DB-9 RS-232 Serial
|Plug/Connector Type
Battery Information
|Backup/Run Time
|0.09 Hour 14.40 kW Full Load
|0.23 Hour 7.20 kW Half Load
|Battery Recharge Time
|<8 Hour
|User Replaceable Hot-swappable
|Network Management
|SNMP Manageable Included
Power Description
|Input Voltage
|Output Voltage
|200 V AC Nominal
|208 V AC Nominal
|220 V AC Nominal
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|Load Capacity
|16 kVA/14.40 kW
|Input Voltage Range
|200 V AC Nominal
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Physical Characteristics
|5.1" Height x 17.5" Width x 25.8" Depth
|Weight (Approximate)
|43.00 lb
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|12U Tower/Rack Mountable
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|2 Year
This product is shipped only within Canada and Warranty valid for Canada only.
Computer Valley makes every effort to provide accurate specifications, descriptions, images and price on all products that are found on www.computervalley.ca
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This is a list of locality names and populated place names in the state of Victoria, Australia, outside the Melbourne metropolitan area. It is organised by region from the south-west of the state to the east and, for convenience, is sectioned by Local Government Area (LGA).
Localities are bounded areas as recognised by the Registrar of Geographic Names acting under the Geographic Place Names Act (1998), although boundaries are the responsibility of each council. Many localities overlap LGA boundaries, some being partly within three LGAs, but are listed here once under the LGA in which the major population centre or area occurs. Detailed maps showing locality boundaries within a LGA are available on the Land Victoria website.
Research Tips


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Sir Dave Brailsford has stepped down as British Cycling performance director to concentrate full-time on his role as Team Sky principal, the national governing body has confirmed.
Brailsford has led Britain's cyclists to an unprecedented period of success, with eight gold medals at the Beijing and London Olympics and has arguably been more influential than any other person in turning cycling into a mainstream sport in this country.
The 50-year-old Welshman also established Team Sky, winning the Tour de France through Sir Bradley Wiggins in 2012 and Chris Froome in 2013.
"This is a big step but it is the right decision for the team and for me," Brailsford said.
"Since London 2012, we have worked hard on succession planning and that has meant we've got to a point where I can move on, knowing the team will go from strength to strength."
The decision was made following an internal review.
Shane Sutton, Brailsford's right-hand man in more than a decade of success and previously performance manager, has been named technical director, while Andy Harrison will continue as programmes director.
A new role of head of performance support will be created.
As well as Brailsford, Professor Steve Peters will leave British Cycling, stepping down as the team's psychiatrist.
Peters now works with a range of other individuals and teams and will work with England's footballers ahead of the World Cup in Brazil this summer.
Brailsford added: "I'll still be available to Ian, Shane and Andy for support if they need it and my role at Team Sky will mean we'll still work closely and support the aims of British Cycling.
"I'd like to thank all the great staff who I've worked with and of course the amazing athletes who ultimately deserve all the credit for their success.
"I have some extraordinary memories - not just from Olympic Games and World Championships, but also just day to day seeing cycling go from a fringe activity to a mainstream sport.
"I've always said that, more than any of the medals, the transformation of cycling in Britain is the single thing I'm most proud of having helped achieve."
The success of Team Sky has effectively forced Brailsford's hand as he has determined that the two jobs have become too big for one man to combine.
This is gearing up to be another big year for Team Sky with the Tour de France starting in Yorkshire and the Giro d'Italia in Belfast.
The team is also opening a new performance centre in the south of France which would have pulled Brailsford away from British Cycling's Manchester base.
Brailsford, who considered his future with British Cycling after the London Olympics before deciding to stay on, has missed two successive Track World Championships due to Team Sky commitments, including February's event in Cali, Colombia where a disappointing performance prompted a fresh review of team operations.
Brailsford joined British Cycling in 1998 and took over as performance director when Peter Keen left in 2003.
His focus on mental preparation and the exploitation of "marginal gains" revolutionised the culture of the sport and led to a glittering array of honours.
Brailsford was knighted after the London Games.
Brailsford and Peters played leading roles in the review and were confident the structures they put in place have left the organisation in a position to continue to go from strength to strength.
British Cycling chief executive Ian Drake said: "I want to thank Sir Dave Brailsford for his enormous contribution to British Cycling - the organisation he leaves behind is transformed from the one we both joined in 1998.
"In that time the Great Britain cycling team has not only set the standard by which British sporting success is judged but also inspired millions of people to get active through cycling.
"The sport of cycling in this country has travelled a long way in the last few years but the best is yet to come."
Peters was influential in the long and successful careers of Olympic champions including Sir Chris Hoy and Victoria Pendleton. He will help implement a new support system before he departs.
"It has been an amazing 10 or so years and I consider myself fortunate to have been part of a team which has achieved such great things," Peters said.
"However, I think the time is right for a change and I look forward to seeing the team prosper."
Sutton paid tribute to Brailsford, acknowledging his friend's contribution.
Sutton said: "He leaves a big hole but we have a fantastic system in place from playground to club to podium with a great team throughout the organisation and I am very confident looking ahead to Rio.
"Andy and I know we can always pick up the phone to Sir Dave but in the meantime we are looking forward to getting on with the business of winning medals and working with an exciting generation of talented British cyclists."


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First it was Elmo, the lovable Sesame Street character. We learned the person who has voiced the cuddly red monster for all these years, 52-year-old Kevin Clash, resigned in November after repeated accusations that he had sex with underage boys.
This week we learned that the voice of Charles Shulz's character Charlie Brown, 56-year-old Peter Robbins, was charged with stalking and threatening his former girlfriend and a plastic surgeon who gave her a breast enhancement. Robbins pleaded not guilty Wednesday in San Diego Superior Court to two counts of stalking and 10 counts of making criminal threats.
Robbins was just 9 years old back in the 1960s when he was cast as the hapless blockhead for the TV specials "A Charlie Brown Christmas," "It's The Great Pumpkin, Charlie Brown" and "A Boy Named Charlie Brown."
While I didn't find any sordid stories in the backgrounds of other voice actors, it was interesting to find out who were the real people behind other characters.
Kermit the Frog, of course, was voiced by Muppets creator Jim Henson, who died in 1990. Steve Whitmire took over as "Kermie" from there. Henson's Sesame Street character Big Bird has been voiced by Carroll Spinney since 1969, but Spinney is aging, so others, including Matt Vogel in 1998, have been groomed for the part.
TV cartoon sensation Homer Simpson plus "The Simpsons" characters Grampa Simpson, Krusty the Clown, Barney Gumble, Groundskeeper Willie and Mayor Quimby are all voiced by Dan Castellaneta. Troublemaker Bart Simpson is brought to life by Nancy Cartwright.
Going way back to the early days of cartoons, did you know that Walt Disney himself was the voice of Mickey Mouse from 1928-1947? He even did Minnie Mouse in 1928. Of course, Mickey's been around a long time, and Jimmy MacDonald did his voice from 1947-1977, Wayne Allwine from 1977-2009 and Bret Iwan from 2009 to the present.
Paramount's Popeye character was voiced by Jack Mercer, and Mae Questel was the voice of Olive Oyl as well as Betty Boop.
The Hanna-Barbera cartoons of the 1960s featured Daws Butler as Yogi Bear, Quick Draw McGraw, Snagglepuss and Huckleberry Hound. He even filled in as Barney Rubble on "The Flintstones" while voice actor Mel Blanc was recovering from a serious traffic accident.
Blanc's resume was endless as the voice of Warner Brothers characters such as Bugs Bunny, Daffy Duck, Porky Pig, Tweety Bird, Sylvester the Cat, Yosemite Sam and Foghorn Leghorn. Later Blanc did Barney Rubble and Mr. Spacely in "The Jetsons" for Hanna-Barbera.
Blanc died in 1989, the epitome of beloved voice actors — and with no police record.


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Braintree's game gets frozen out
7:48pm Thursday 17th January 2013
By Simon Spurgeon
7:48pm Thursday 17th January 2013
By Simon Spurgeon
Braintree Town have confirmed that Friday's Blue Square Bet Premier fixture against Grimsby Town has been postponed due to snow and frost on the Amlin Stadium pitch.
Following a pitch inspection on Thursday evening, Iron chairman Lee Harding posted on the club's fans' internet messageboard to confirm that the game would not go ahead.
A heavy blanket of snow still on the playing surface along with sub-zero temperatures and further snowfall forecast in the lead-up to the game meant the game had to be postponed.
It means Braintree's next scheduled fixture will be their league game at Dartford on Tuesday.
© Copyright 2001-2017 Newsquest Media Group


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3 results
Springtime has sprung upon us. Well maybe it's just about to start or it has long gone but either way these springy ideas are a breath of fresh air all year round. Whether barbequing, sunbathing or looking to grow something unusual in your garden we have plenty of garden and home gift ideas to freshen up your domestic space.


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Finance for Non-Financial Managers
This event occurred in the past
Date and Time
- Friday, March 30, 2012 from 7:30 a.m. to 5:00 p.m.
Mother Rosalie Hill Hall, Room 102
- Buffet-style breakfast served from 7:15 a.m. – 8 a.m.
- Lunch held from 12 p.m. – 1 p.m.
- Program held from 8 a.m. – 5 p.m.
A reasonable understanding of finance could expand your career opportunities and enhance your value to an organization. This one-day program is designed for non-financial managers in any functional area within any industry. Your participation will allow you to master some tools of finance that will be immediately useful to you. It will also serve to build an appreciation for the financial impact of your business decisions and achievements.
- Learn why you need financial statements
- Learn how they impact your job and to your future resources
- Understand the structure and purpose of the three main financial statements filed by US companies
- Be able to assess the basic financial health of a company by conducting simple ratio analyses
- Be aware of current issues in financial reporting
- Learn easy techniques of valuation using Excel (bringing your laptop is highly encouraged)
Annalisa Barrett is a full-time lecturer in the Finance Department at the University of San Diego's School of Business Administration. She teaches graduate courses in Corporate Governance and undergraduate courses in Financial Management, Financial Statement Analysis and Personal Finance. She was formerly vice president and senior research associate with The Corporate Library. She led the firm's research related to board and governance practices. She has been quoted in numerous periodicals, including USA Today, Compliance Week, American Banker and the San Diego Business Transcript and her research has been featured on the front page of the Wall Street Journal. Barrett has an MBA, with distinction, from the University of Michigan Business School. She is a member of the Board of Directors of the Corporate Directors Forum and Volunteers of America Southwest.
Shreesh Deshpande has been a member of the finance faculty at the University of San Diego since 1988. He is the Area Chair of Finance in the School of Business at USD. His primary interest is Corporate Finance and he teaches in the undergraduate, MBA and executive programs. He has been recognized for outstanding teaching and service by graduate students, undergraduate students and alumni. He has served on the Board of the San Diego chapter of the Financial Executives International. He has published refereed articles in the areas of corporate finance, international finance and derivatives and was a recipient of competitive external research grants. Dr. Deshpande has an undergraduate degree in Mechanical Engineering and an MBA. He earned his PhD from Penn State.
The event fee is $345 per participant. Students, alumni and groups of three or more from the same organization are eligible for a $50/person discount.
Please contact email@example.com to obtain the discount code. Go to http://F4NFM.kintera.org/ to register.
Please contact Gina Fascilla at firstname.lastname@example.com or (619) 260 4807 if you have any questions.
Post Contact
Gina Fascilla
(619) 260-4807


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Brand Names: Cardizem, Cardizem CD, Cardizem LA, Cartia XT, Dilacor XR, Dilt-CD, Diltia XT, Diltiazem Hydrochloride CD, Diltiazem Hydrochloride SR, Diltiazem Hydrochloride XR, Diltiazem Hydrochloride XT, Dilt-XR, Diltzac, Taztia XT, Tiazac
Generic Name: diltiazem (Pronunciation: dil TYE a zem)
- What is diltiazem (Cardizem LA)?
- What are the possible side effects of diltiazem?
- What is the most important information I should know about diltiazem?
- What should I discuss with my healthcare provider before taking diltiazem?
- How should I take diltiazem?
- What happens if I miss a dose?
- What happens if I overdose?
- What should I avoid while taking diltiazem?
- What other drugs will affect diltiazem?
- Where can I get more information?
What is diltiazem (Cardizem LA)?
Diltiazem is in a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels.
Diltiazem is used to treat hypertension (high blood pressure), angina (chest pain), and certain heart rhythm disorders.
Diltiazem may also be used for purposes not listed in this medication guide.
What are the possible side effects of diltiazem?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
- a red, blistering skin rash;
- swelling in your hands or feet;
- trouble breathing;
- slow heartbeats;
- dizziness, fainting, fast or pounding heartbeat;
- upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
- severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious side effects may include:
- headache;
- dizziness, weakness, tired feeling;
- upset stomach, nausea;
- sore throat, cough, stuffy nose; or
- flushing (warmth, redness, or tingly feeling).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Read the Cardizem LA (diltiazem) Side Effects Center for a complete guide to possible side effects
What is the most important information I should know about diltiazem?
Do not use this medication if you have certain heart conditions such as "sick sinus syndrome" or "AV block" (unless you have a pacemaker), low blood pressure, or if you have recently had a heart attack.
Before taking diltiazem, tell your doctor if you have kidney disease, liver disease, or congestive heart failure.
Diltiazem may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Do not stop taking this medication without first talking to your doctor. If you stop taking diltiazem suddenly, your condition may become worse.
Diltiazem may be only part of a complete program of treatment that also includes diet, exercise, and other medications. Follow your diet, medication, and exercise routines very closely.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms.
What should I discuss with my healthcare provider before taking diltiazem?
You should not use this medication if you are allergic to diltiazem, or if you have:
- certain heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
- low blood pressure; or
- if you have recently had a heart attack.
To make sure you can safely take diltiazem, tell your doctor if you have any of these other conditions:
- kidney disease;
- liver disease;
- congestive heart failure; or
- if you are also taking clonidine (Catapres).
FDA pregnancy category C. It is not known whether diltiazem will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Diltiazem can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take diltiazem?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
Take diltiazem with a full glass of water.
Do not crush, chew, break, or open an extended-release tablet or capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.
If you have trouble swallowing a diltiazem capsule whole, ask your doctor or pharmacist if it is safe for you to open the capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.
Use diltiazem regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Do not stop taking this medication without first talking to your doctor. If you stop taking diltiazem suddenly, your condition may become worse.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Diltiazem may be only part of a complete program of treatment that also includes diet, exercise, and other medications. Follow your diet, medication, and exercise routines very closely.
To be sure this medicine is helping your condition and is not causing harmful effects, your blood pressure will need to be checked often. Your liver and kidney function may also need to be tested. Visit your doctor regularly.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diltiazem can be fatal.
Overdose symptoms may include slow heartbeat, weakness, chest pain, shortness of breath, feeling light-headed, or fainting.
What should I avoid while taking diltiazem?
Diltiazem may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid drinking alcohol while taking diltiazem.
Grapefruit and grapefruit juice may interact with diltiazem and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Avoid exposure to sunlight or tanning beds. Diltiazem can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
What other drugs will affect diltiazem?
Tell your doctor about all other medicines you use, especially:
- amiodarone (Cordarone, Pacerone);
- buspirone (BuSpar);
- carbamazepine (Carbatrol, Tegretol);
- cimetidine (Tagamet);
- cyclosporine (Gengraf, Neoral, Sandimmune);
- digoxin (digitalis, Lanoxin, Lanoxicaps);
- quinidine (Quin-G);
- rifampin (Rifadin, Rimactane, Rifater);
- an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);
- antifungal medication such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend);
- a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
- cholesterol medications such as atorvastatin (Lipitor, Caduet), fluvastatin (Lescol), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin);
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), or ritonavir (Norvir, Kaletra); or
- a sedative such as midazolam (Versed) or triazolam (Halcion).
This list is not complete and other drugs may interact with diltiazem. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about diltiazem.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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Your use of the content provided in this service indicates that you have read,understood and agree to the End-User License Agreement,which can be accessed by clicking on this link.


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I have been following the Blake style minimalist less overstabloe disc program. I am very happy with this program, as in a short period of time I have learned that throwing long and straight is mostly about the throw aad not the disc.
I have a stack of Pro Cyclones and few D Cyclones. Their flight vary very consistently by weight. Heavier discs are mosre stable lighter, less so (the exeption being the "more overtable" POS Cyclone2 I have in X plastic that flips over faster than Paris Hilton) . The Cyclone flies generally about the same even when warped and pretty beat, and I have only thrown one away that I bought from the used bin). The disc has to be totally beat, and I mean totally beat not to fly pretty much normally.
One thing I have noticed is that the D-Cyclone is noticably slower than the old "Cyclone plastic" Cyclones, and those "Cylcone plastic" discs are slower than than my first run Cyclone. While the furst run Cyclone is noticably longer (by about 30' on average) the D Cyclone is just as long as the Pro EVEN THOUGH IT FLIES SIGNIFICANTLY SLOWER.
In an effort to find a faster, longer Cyclone, I bought 3 DX Eagles. The main concern being the rim width. I have a grip that works very well with all of my discs (Cyclone, Roc, Aviar, Cheetah) and I HATED the fact that my grip had to change once you gradualted to an Orc or Wraith. I HATE THIS!!! "Old style" discs have no wing, and mostly bead, and the rim fits into the crook of my index finger just great, so I went to the store and found a disc with a cyclone like bead tha fit my grip.
The Eagle is good disc and is very "fast", even compared to a Wraith (I think). The glide (for me) is very Wraith like, in fact. One point of fact is that DX plastic "glides", period, and there is no need for a huge wing to get the glide, like you need from CE plastic. The flight of the Eagle is very Cyclone like (small hyser flip, almost no fade) but is much less forgiving than a Cyclone. The Eagle is significantly more forgiving than a Wraith, Orc, etc. Nose angle is so critical on these discs for max D.
I have my longest field throw to date with my 172 Eagle, which was 480 feet. It was all in the glide, not the snap BTW.
Glide is everything, the disc must FLY to go far IMHO. Everyone is so enamored with speed, but the it is the glide that ALWAYS gets the big D for me. Speed is just easier to throw 350' (hence the overwhelming popularity of fast discs). After that most people need glide. Also, are people willing to throw these discs against each other in a field and truly see the difference? I doubt it, or they might be wondering why they would sacrifice pinpoint accuracy for 3-5 steps in distance (and most likely only at certain wind angles)...
...I have a buddy that can tomahawk a CE Orc 300', and it never "flies" (in the true flying disc sense) at all. I "fly" my Aviar 300'. In a real sense, maybe not as effective overall, but I do not see throwing overhand as improving any other aspect of the flying disc arsenal. In other words, try tomahawking a 150' tight tunnel shot.
Yesterday I bought two DX Teebirds. The disc appears to be a refined Eagle, and has almost ZERO fade. It appears to be even a bit more forgiving than the Eagle, but I am not will to say that yet. It actually flies like a fast Roc (although not nearly as forgiving as a Roc) and the glide is dead straight. If the wind is not blowing in excess it will go right where you point it (like a Roc), and is very long with a reasonably good snap.
This brings me to my question, if the wind is blowing what would be a good disc for headwinds, with a short wing (small bead), in DX type plastic (it does not necessarily be Innova)? Is the XS overstable enought to be a headwind disc?


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Family life doesn't always go according to plan. Agony aunt Suzie Hayman talks about her new book - Teach Yourself How To Have A Happy Family Life - which guides mums and dads through all manner of challenges, from establishing routines with babies and tots, to coping with teenage conflicts.
By Lisa Salmon
Happiness may be the greatest gift that we possess, but in the hectic whirl of modern family life, it's often a lost treasure.
Parents get so wrapped up in the trials and tribulations of bringing up kids, from the slog of sleepless nights with a newborn to the challenges of teenage conflict, that the pursuit of happiness can become a forgotten luxury.
But happiness should be at the core of family life, argues agony aunt Suzie Hayman, whose belief in the power of being happy appears to be shared by Prime Minister David Cameron, who created a national 'happiness index' which published its first results in July.
Hayman, a trustee of the parenting charity Family Lives, has written the book Teach Yourself How To Have A Happy Family Life in a bid to help get families back on the road to happiness.
She says that for many families who are just 'getting by', low-grade conflict or stress is seen as normal.
"But both are not just uncomfortable," she warns, "they are destructive and painful and ultimately extremely damaging."
Indeed, she points out that many of the ills in today's society, such as anti-social behaviour, vandalism and crime, stem from unhappy childhoods, and certainly a report by Unicef last year concluded that British children are among the least happy in the developed world, because of a lack of contact with their parents and too much emphasis on material gain.
Hayman hopes her book will help combat this unhappiness both by encouraging more family time together, and tackling the many flashpoints in family life, right from starting off as a new couple to living with grandparents, with a view to steering towards a happy ending.
She stresses that certain ground rules are needed in a happy family, such as routine, children doing chores, boundaries and rules, but points out that once they're in place "it's like having a safety belt and you're then free".
She adds: "It's not marching in step, it's using parenting skills that lead to people communicating and feeling they can talk to each other, having time together and prioritising the important aspects of family life."
She champions routines not just for obvious situations such as bedtimes and before school, but for when parents want kids to do as they've asked without it ending in conflict.
To avoid meal times rows, for example, she says before starting cooking a parent should make eye contact with their child, touch them and say their name rather than shouting from the other room. Then tell them when the food will be ready and ask them to repeat what has been said.
Check with them every five minutes with a countdown, repeating the eye contact, etc. When you say the meal's ready, descriptively praise them if they come straight away, telling them exactly why you're pleased with them.
If they don't come after you've given them a hug and said how hungry they must be, go and eat and ignore them, and don't be drawn into an argument. Be upbeat and calm, and Hayman says the chances are the child will join you - at which point, you still descriptively praise them.
"It feels clumsy and artificial and awkward at first," she warns.
"After a few repetitions and successes, you'll see how useful this way of doing things is."
Clearly, this isn't happy-clappy preaching, but down-to-earth, sensible advice that steers away from family conflict - although Hayman stresses that it all takes time and effort, and concedes that every so often parents will 'lose it', forget about being the parent they want to be and shout, snap and be impatient and unfair.
But she says this is unlikely to scar children for life, as long as the loss of control is a one-off and you're doing your best.
It's important to get the balance right between guiding children firmly and listening to their needs, wishes and opinions, she says, and the teaching and communication strategies needed are often - but definitely not always - the same whether the child's an infant or a teenager.
With teenagers she suggests regular family discussions to help deal with disagreements, shared family meals, and no electronic media in bedrooms.
She suggests 'idea storming', where parents and teenagers give themselves a time limit to write down their own solutions to a specific problem. After time's up, discuss the ideas without criticising them.
Hayman says "a gem of a solution" can often be found in this way, and it makes the whole family feel involved and much more likely to try to make the solution work.
"I get so many letters from parents asking about discipline and how to solve conflict, and I tell them that the premise they should be starting from is, 'How can we be happy?'
"I don't think that's a wishy-washy, trivial concept. If people are happy, so much flows from it - you're a more effective partner, parent and worker, your children behave better and do what you want them to."
She stresses that giving children what they ask for - be that chocolate, an iPad or a late night - doesn't make them happy, as often what they really want is their parents' attention and proof of love.
"I think the best present parents could give their children this Christmas is either just time, or a board game that they can all play together as a family."
She adds: "A happy family does have plenty of chaos and people running around screaming - with laughter.
"I know people have a lot on their plates because life is so busy, but if you make an effort to try to improve life, within days you'll find things are so much easier. Putting in that initial effort pays off in saved time, saved wear-and-tear, saved conflict and saved angst.
"You won't believe the difference - it's transformational."
:: Teach Yourself How To Have A Happy Family Life by Suzie Hayman is published by Hodder Education, priced £10.99. Available now.
Ask the expert
Q: "My 10-year-old son wants to cycle to school, about a mile away in a residential area, but I'm worried that it's too dangerous. Am I being too cautious?"
A: Julie Townsend, deputy chief executive of Brake, the road safety charity, says: "It's brilliant your child wants to cycle; it's fun, healthy, and environmentally friendly.
"But we understand your concerns about safety. Many communities are plagued by fast traffic, with few facilities for cyclists.
"To help you decide, work out if there's a safe route. Check out if there are off-road or separate cycle paths, or if not, very quiet streets with little traffic and low speeds.
"If he needs to cross busier roads or junctions, tell him to get off his bike and use pavements and crossings, and be confident he will.
"Try cycling the route yourself, and with him the first times, to make sure it's safe.
"If you decide the route is safe, ensure he wears reflective, high-visibility gear and a properly fitting, quality helmet. His bike should be well maintained, with lights for dull weather, although it's safest for him not to ride in the dark until he's older, with more experience.
"If the route to school isn't safe, you can still help your son start enjoying cycling and building experience. Cycling training is great for helping kids understand how to keep as safe as possible - ask the school or council about it. You could also offer to take him for bike rides on local off-road routes or on holiday: a great way to enjoy cycling together.
"Finally, if your neighbourhood isn't blessed with safe routes and low speeds, start a campaign with other parents and your son's school."
:: Road Safety Week is November 19-25. For advice on campaigning for 20mph limits and other measures for safe walking and cycling, visit www.go20.org (from November 19).
Warm and dry
Splash About Apres Splash All In One
This thick cotton towelling all-in-one, which contains bamboo charcoal to help block the spread of infections, will keep baby warm and dry after a bath. Suitable from birth to 18 months, £19.99, available from www.splashabout.com
Baby Boum Hooded Bath Towel and Wash Mitt
This large hooded double-lined baby towel and matching bath mitt are made from a cotton-rich super soft terry fabric. Available from www.amazon.co.uk, £16.71.
Coochi Coocoose Baby Bathing Apron/Towel
Soft cotton adjustable towel that mum or dad wears like an apron as they bathe baby, leaving hands free and clothes dry, before lifting baby out of the water and wrapping baby in the hooded towel. Available from www.babyandmore.co.uk, £24.99.


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TORONADO will spearhead yet another powerful Glorious Goodwood team for Wiltshire trainer Richard Hannon in the Qipco Sussex Stakes as his stablemate Olympic Glory heads to France once again.
The Queen Anne Stakes winner collected his first Group One when getting the better of his old adversary Dawn Approach in last season's renewal, and is set to clash with the leading three-year-old Kingman on July 30.
Lockinge winner Olympic Glory, last seen finishing fourth to Cirrus Des Aigles in the Prix d'Ispahan, will be attempting to go one place better than his narrow second to Moonlight Cloud in the 2013 Prix Jacques Le Marois.
There has been a change of order at the Hannon establishment in Collingbourne Ducis, which was bathed in sunshine this morning.
While son Richard is now in charge, Hannon snr was overseeing work duties with the licence holder away in France.
"Toronado will run in the Sussex, all being well," he said.
"He's had his problems with his wind, but he's as good a horse as we've ever had here. He's definitely on a par with (2010 winner) Canford Cliffs."
Kingman reversed placings from the 2000 Guineas with Hannon's Night Of Thunder when a resounding winner of the St James's Palace Stakes and John Gosden's colt is currently the odds-on favourite for the Sussex.
Hannon snr said: "I'm not sure (Kingman) will like the track. But if he goes there right and everything's well, he'll take a lot of beating.
"I'd like Toronado to stay in training next year, but the boss (owner Sheikh Joaan) has his stud in France and he might want him to go off there. It hasn't been discussed.
"Olympic Glory will follow the ground, he likes a bit of cut, and he'll probably go for the Jacques le Marois."
Aside from a stack of two-year-olds, Hannon has last year's leading juvenile Toormore in contention for Glorious Goodwood.
The winner of the Craven Stakes must show a bit more following defeats in the Guineas and St James's Palace and is now set to drop back to seven furlongs.
"He ran a bit flat in the Guineas, I thought he was a bit dull in his coat, but he looks all right now," said Hannon.
"He'll run in the Lennox Stakes, he'll have no problems dropping back."
Night Of Thunder himself was most recently seen tackling a mile and a quarter for the first time in the Coral-Eclipse, but beat only one home.
"I thought he didn't get the trip, but it was a stupid race and those at the front got away with it," said Hannon.
"We went all over him after Sandown, he had a bone scan, his scope was good. The Prix du Moulin's what they're talking about now."
The five-day Glorious Goodwood meeting is now just two weeks away and clerk of the course Seamus Buckley said: "If it was today, I'd be calling it good to firm. We'll just keep it going, but we're where we want to be at the moment."


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I have found that if somebody posts a link as part of a post, and you click on it, it is vital you don't close the link down by clicking on the X-button (white x on red) in the top right-hand corner of the screen.
This will also close the whole "Dhamma Wheel" website down, and you'll have to come back in.
To come out of the link, hit the back-arrow, top left of your screen.


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I really like this section of the web page and was wondering how often you update it and HOW you update it? Do you take a poll somewhere that I'm missing?
Just wondering because I'm waiting to see some reviews on the Gateway Inferno and the Whitler from Snap. I would think the Inferno, at least, could be up for an award (at least by what I've been hearing so far).


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Great NE Reading row currently rented at $695. Tenant pays all utilities. Awesome rental or would make great starter home. City code compliant. Can also be purchased as part of an investment package, "1001 Main St", located in MLS under both commercial and multi unit categories.
Listing Area: Reading City (10201)
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