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We called it "thesis investing," and I hated it. That's right, when I ran my hedge fund, I always heard these big think-people on air and in print and at meetings talking about top-down economics and then shoe-horning stocks into their views from the top down.
Frankly, it rarely worked, and more importantly, when it went awry, it produced spectacular losses for anyone who attempted it.
Right now, you are seeing the residue of thesis-investing playing out on your screens. The thesis in play had been the hobbling of the U.S. consumer. The litany of woes the consumer is facing -- higher payroll taxes, higher gasoline payments, relentless dysfunctional behavior in Washington sure to lead to a job-cutting sequester, even delayed tax refunds from the IRS said to total more than $30 billion -- all add up to what should have been tremendously disappointing earnings for the retailers.
When you think about it, the thesis makes so much sense and was so easily applied because the earnings season for retail came right after we were certain that every consumer should have been blown by what are endlessly referred to as headwinds. How could the retailers duck these profoundly damaging concerns to their pocketbooks?
So these thesis investors put on short after short to profit from the certain decline. They shorted the ETFs. They shorted the department stores. They shorted the discounters and the dollar stores. And they shorted the big housing derivative retailers.
The result? A squeeze up of pretty remarkable proportions, as the facts didn't fit their story, and the shorts were forced to cover.
Think about it. Wal-Mart (WMT) started things off with a much better than expected quarterly report, and while some tried to seize on the outlook, which was muted -- the "some" most likely influenced by the shorts spreading the bad word -- the stock went higher and then has refused to come in.
Then we got Home Depot (HD) and Macy's (M), two disparate but powerful nationwide retailers that both reported amazing earnings and signaled not only that was there no spending weakness but that spending might be accelerating. That was certainly the takeaway from Home Depot.
Today it's the dollar stores. When we last left them in the previous reporting period, it was a total debacle, sloppy sales and terrible outlooks with lots of chatter about declining gross margins, the kiss of death.
Whoops, Dollar Tree (DLTR) reported a beautiful number, and while guidance wasn't blown away, it did report a dramatic increase in gross margins. Talk about not fitting the thesis, this was an extraordinary reversal and the exact opposite of what the bears thought they would hear, and believe me, they were lying in wait for these firms.
To make matters worse, the restaurants wouldn't comply with the thesis either, as DineEquity (DIN), also known as IHOP and Applebee's, Cracker Barrel (CBRL), Jack in the Box (JACK) and Darden Restaurants (DRI) all either reported a terrific story or said things are getting better.
Now, of course, not every company is executing well enough to take advantage of what I can only call consumer strength. Target (TGT) and Lowe's (LOW) got beaten by the other guys, and if there were headwinds, they were headwinds coming from the front doors of their stores.
But even they managed to recover, because, again, the shorts had no game here.
Yep, the facts just refused to comply. The consumer refused to read the headlines or listen to the news or realize how poor she had become. She simply accelerated her spending at the exact time she was supposed to be curtailing it. As we would say on the desk: a good short spoiled.


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Staffing and contact information for the Barbourville Independent school district
NOTE: To send e-mail to district staff, the e-mail addresses are typically defined as firstname.lastname@example.com. For example: The e-mail address for an employee named Daniel Boone would be email@example.com. The e-mail address for an employee named George Washington would be email@example.com.

subset: commoncrawl


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Content on this page requires a newer version of Adobe Flash Player.
Welcome to Denver, Colorado and the most comprehensive real estate website for the Colorado Front Range! If you are searching for Denver area homes or Denver real estate you've come to the best place! If you need an experienced team and expert help with real estate you've also come to the right place! The Richards Group together with their hand-picked Keller Williams Real Estate Family members, home builders and strategic partners make a dynamic team that stands out among the masses as consummate professionals with keen business instincts and an innate ability for skillful negotiating.
This website features maps and statistics, abundant photography, tips on gardening and cooking at our altitude, school information, focus on shopping and entertainment activities, things to do in our beautiful natural surroundings, and, of course, complete information about real estate, condominiums and land for sale in the area.
We can assist you with properties for sale in Arvada, Aurora, Boulder, Brighton, Broomfield, Castle Pines North, Castle Rock, Centennial, Cherry Hills Village, Colorado Springs, Commerce City, Conifer, Elizabeth, Englewood, Erie, Evergreen, Foxfield, Franktown, Golden, Greenwood Village, Highlands Ranch, Kiowa, Lafayette, Lakewood, Larkspur, Littleton, Lone Tree, Louisville, Morrison, Northglenn, Parker, Sedalia, Superior, Thornton, Westminster, Wheat Ridge within Arapahoe County, Adams County, Boulder County, Broomfield County, Denver County, Elbert County, El Paso County, Douglas County, Jefferson County, Colorado.
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Slavery: Not a Thing of the Past
On Tuesday night March 29th, after the preview of Coram Boy, there will be a special talkback that will focus on international slavery, the meaning and monitoring or Free Trade, and what we can do to help eliminate the gruesome human cost of making a buck.
Slavery: Not a Thing of the Past
Coram Boy accurately depicts the merciless exploitation of children and slave labor—inhumane conditions that existed long ago and far away. We would like to believe that they no longer exist, but in actual fact there have never before in history been more slaves, internationally and in 90 cities of the Unites States. And never before has the price of a human life been lower; while a slave cost roughly the equivalent in today's currency of $40,000 during the Civil War era, today a slave costs under $100, and sometimes far less. No wonder Kevin Bales, the founder of Free the Slaves, calls them "Disposable People." Many of the products we purchase – including, to name just a few, chocolate, coffee, sneakers, computers and rugs--rely on slave labor.
On Tuesday night March 29, after the preview of Coram Boy, there will be a special talkback that will focus on international slavery, the meaning and monitoring or Free Trade, and what we can do to help eliminate the gruesome human cost of making a buck.
Please join us for this important discussion, and join the interdisciplinary IC movement to address slavery through individual, community and global action.
Attendance is free and all are welcome. You need not attend the show, but we hope you will!
Guest speakers:
Chirag Desai is Treasurer for 10,000 Villages, a national movement to support humane working conditions and living wages by selling artisan goods at fair prices. Desai runs a software development company, but invests much of his time in the development of a shelter for human trafficking victims. His activism began with his consciousness of social justice in his native Ethiopia.
Jessica Leuchtenburgis, a Junior at IC, is President of the IC chapter of Free the Slaves, the revolutionary international organization begun by Kevin Bales and his landmark research into global slavery. She has been an abolitionist since the age of 11.
The discussion will be moderated by dramaturg and activist Dr. Susan Jonas from the Theatre Arts program. Presented with Much Ado About Outreach. Please contact email@example.com with any questions.
Originally published in Intercom: Slavery: Not a Thing of the Past.


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Indiana receives: Gerald Wallace and Jamal Crawford
Portland receives: Dahntay Jones and two 1st round picks
Portland saves some money this year and next while bringing in 2 1st rounders and possibly AJ Price if he sweetened the deal, although I'd like to hang on to him.
The possibilites are endless with that rotation... Hill, Crawford, George, Wallace, Hibbert. Collison, George, Granger, Wallace, Hibbert. Crawford, Hill, George, West, Hibbert.
We may be over the cap next year even if Crawford opts out, but we'd still be able to re-sign Hill and Hibbert and remain under the luxury tax I think. The following off-season, West and Wallace expire and Granger has 1 year left. That leaves a ton of flexibility.
This year? We can beat MIA and CHI in a 7 game series


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Southern California may be poised for some sprinkles this week, but don't reach for the umbrellas yet, weather forecasters said Monday.
A storm drifting down from Northern California is expected to bring a slight chance of rain as early as tonight with a 50-percent chance by Thursday, the National Weather Service said.
"There's shower possibilities – first fall rain," said Weather Specialist Bonnie Bartling. "We're generally talking across the region 0.1 inch, or up to .5 inch if there's a thunderstorm.
"Have (an umbrella) handy in the car trunk. Or use it as a walking stick."
Clouds will likely begin to blanket the region on Tuesday, ushering in colder-than-normal highs into the low-to-mid 70s, with lows around 55.
"It's going to be quite a change," said James Thomas, a meteorologist with the National Weather Service.
The San Fernando Valley that baked in 100-plus degree heat last week, could see rain showers by Thursday, along with a slight chance of thunderstorms.
Long Beach reached 97 degrees Oct. 1, but the mercury could drop to 68 degrees later this week. And Torrance, which climbed to 90 degrees Oct. 2, is expected to be 66 degrees.
Local mountains, too, could see a dose of snow.
About 1 to 3 inches of snow is possible on the peaks of the San Gabriel Mountains on Thursday, according to the National Weather Service.
The San Bernardino Mountains may receive several inches of snow in the higher elevations Thursday.
It's not enough to open ski resorts, but resort officials say even a light dusting will put skiing on people's minds.
"I think it will be enough to get people excited about the upcoming season," said Kim Hermon, spokeswoman for Mountain High ski resort in Wrightwood.
Warming is expected Friday through Sunday as the low-pressure system moves east.
Los Angeles has experienced a somewhat dry rainy season, with .01 inches downtown since July 1. Normal rainfall to date is .41 inches. By this time last year, L.A. had 1.15 inches.
Some are calling this year's rainy season "La Nada," based on a relatively neutral average Pacific Ocean temperature that can determine wet El Niño or dry La Niña winters.
The average rainfall for downtown is 15.14 inches. But forecasters say California either swings wet or dry, with La Nada bringing a near-record wet 37.25 inches in 2004-05 and a record dry 3.21 inches in 2006-07.
"Since early spring and summer, the National Weather Service was touting an El Niño – with a greater chance of rain for Southern California. But recently, El Niño took a belly flop," said Southern California climate guru Bill Patzert, climatologist for the Jet Propulsion Laboratory in La Cañada-Flintridge.
"So right now it looks like what I call La Nada – neither a wet El Niño nor a dry La Niña, he said. "So the rainfall this winter is up in the air – it could go either way."


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Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease
This study has been terminated.
(The study terminated early due to slow accrual.)
Dana-Farber Cancer Institute
Brigham and Women's Hospital
Boston Children's Hospital
Merck Sharp & Dohme Corp.
Information provided by (Responsible Party):
Maureen Okam, MD, MPH, Dana-Farber Cancer Institute
ClinicalTrials.gov Identifier:
First received: October 20, 2009
Last updated: June 21, 2017
Last verified: June 2017
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Detailed Description:
Sickle Cell Disease (SCD) is a hereditary anemia that causes the red blood cells to change their shape from a round and doughnut-like shape to a half-moon/crescent, or sickled shape. People who have SCD have a different type of hemoglobin (protein that carries oxygen). This different type of hemoglobin makes the red blood cells change into a crescent shape under certain conditions. Sickle-shaped cells are a problem because they often get stuck in the blood vessels blocking the flow of blood and can cause inflammation and injury to important areas of the body. All babies are born with hemoglobin called fetal hemoglobin (HbF). Soon after birth, HbF production slows down and another hemoglobin called adult hemoglobin (HbA) is made. Clinical studies have shown that increasing the amount of HbF in the blood may prevent sickling of the red blood cells. Vorinostat has been used in the treatment of cancers and in other research studies and information from those suggests that it may help treat SCD by increasing the amount of HbF in the blood. The purpose of this research study is to determine the effectiveness and safety of vorinostat when used to treat SCD.
|Sickle Cell Disease Sickle Cell Anemia
|Drug: vorinostat
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase II Pharmacodynamic Investigation of the Efficacy of Vorinostat to Induce Fetal Hemoglobin in Adults With Severe Sickle Cell Disease Who Have Not Benefitted From Prior Therapy
Resource links provided by NLM:
Genetics Home Reference related topics: sickle cell disease
MedlinePlus related topics: Sickle Cell Anemia
Drug Information available for: VorinostatU.S. FDA Resources
Further study details as provided by Maureen Okam, MD, MPH, Dana-Farber Cancer Institute:
Primary Outcome Measures:
- Percent Fetal Hemoglobin (HbF%) Induction Success Rate [ Time Frame: HbF% was measured at baseline and weekly on treatment. Median duration of treatment was 3 months. ]Success will be defined by comparing the maximum HbF% on study drug to the HbF% at baseline. An absolute increase in HbF% of 4% of more, or an increase to 100% or more of baseline in patients with HbF under 4% at baseline will be considered a success. HbF% induction success rate is calculated as the count of successes divided by the count of patients in the analysis population.
Secondary Outcome Measures:
- F-Cell Percentage Level [ Time Frame: Measured at baseline and end of treatment, up to 16 weeks. ]F-cell percentage levels were estimated based on established methods.
- γ-globin to β-globin Ratio [ Time Frame: Measured at baseline and end of treatment, up to 16 weeks. ]Levels of peripheral blood γ-globin to β-globin messenger RNA were estimated based on established methods. The ratio of γ-globin to β-globin was then calculated.
|Study Start Date:
|October 2009
|Study Completion Date:
|October 2014
|Primary Completion Date:
|October 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Vorinostat
Patients received vorinostat in a pulsed fashion, once a day for 3 consecutive days every week to a maximum dose of 400 mg per dose (1200 mg/wk), for 12 to 16 weeks at the maximum dose. The first 3 patients were enrolled in an intrapatient dose escalation schedule of 100 mg/d, then 200 mg/d, each for 3 consecutive days a week for 4 weeks, and then 400 mg/d, 3 consecutive days per week for 16 weeks. The last 2 patients were enrolled to receive 400 mg/d, 3 consecutive days per week for 12 weeks, without an initial dose escalation.
Drug: vorinostat
Other Name: SAHA
Detailed Description:
- To determine the efficacy of vorinostat (suberoylanilide hydroxamic acid, SAHA), when administered orally, in a pulsed fashion, once-a-day for 3 consecutive days every week, in inducing a 4% absolute increase or a 100% increase in fetal hemoglobin percent levels (HbF%) in subjects with severe sickle cell disease who have failed prior therapy.
- To characterize the safety and tolerability.
- To assess the effect of vorinostat on F-cell levels.
- To determine the changes in y-globin, B-globin and E-globin RNA levels during treatment with vorinostat.
- To describe the dose-response characteristics of vorinostat in inducing fetal hemoglobin in sickle cell disease.
- To determine the extent and duration of global histone acetylation with intermittent vorinostat dosing.
- To correlate the status of polymorphisms near the BCL11A, c-myb, and HBB gene loci, all of which are associated with levels of fetal hemoglobin, to assess for an association of polymorphism status with therapeutic response to vorinostat.
- To evaluate red blood cell rheology before and after treatment with vorinostat.
This was a single stage design to evaluate induction of HbF on treatment with target enrollment of 15 patients. A 25% success rate was considered evidence of activity in this patient population while 5% success rate deemed ineffective. If at least 3 patients achieved success, the treatment would be considered promising. With 15 eligible patients, the probability of observing this was 0.76 assuming a true rate of 25% and 0.04 assuming a true rate of 5%.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diagnosis of sickle cell disease
- Clinically significant disease defined as at least 1 painful episode per year averaged over the previous 3 years or a history of priapism, stroke, acute chest syndrome, avascular necrosis, multi-organ failure or the need for chronic narcotic medications for pain from sickle cell disease
- Must have failed a previous attempt at treatment with hydroxyurea defined as the inability to achieve a significant absolute increase in % fetal hemoglobin or the inability to tolerate hydroxyurea treatment due to severe side effects such as but not limited to myelosuppression, gastrointestinal symptoms, edema or hepatic enzyme elevations or have contraindications to hydroxyurea
- 18 years of age or older
- Hematologic laboratory values as outlined in the protocol
- Non-hematologic laboratory values as outlined in the protocol
- Must agree not to donate blood or other bodily fluid while taking the study drug and for 28 days thereafter
- Women of child-bearing potential (WCBP) must have a negative serum pregnancy test 72 hours or less prior to starting treatment
- Women of child-bearing potential and men must agree to use 2 forms of adequate contraception prior to study entry and for the duration of study participation
Exclusion Criteria:
- Subjects with hemoglobin SC or SB+ thalassemia
- Subjects on chronic transfusion program
- Subjects who have received RBC transfusions cannot have >15% adult hemoglobin
- Known positive status for HIV, active hepatitis B or hepatitis C
- Pregnant or breast feeding women
- Individuals with a history of malignancy are ineligible except for the following circumstances. Individuals with a history of malignancy are eligible if they have been disease-free for at least 5 years and are deemed by the investigator to be at low risk for recurrence of that malignancy. Individuals with the following cancer are eligible if diagnosed and adequately treated within the past 5 years: cervical or breast cancer in situ, and basal cell or squamous cell carcinoma of the skin
- Subjects with a history of thrombosis or other reason (other than sickle cell disease) for enhanced thrombotic risk
- Subjects with unresolved infections
- Severe or uncontrolled medical conditions that could compromise study participation
- Subjects on fetal hemoglobin inducing agents
- Subjects on any other experimental treatment within 90 days of the first dose of study drug or who have not recovered from the side effects of such therapy
- Known allergic reaction to a histone deacetylase inhibitor
- Subjects who have received valproic acid for treatment of epilepsy within 30 days of enrollment
- Subjects who have received any HDAC inhibitors other than valproic acid
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01000155
Please refer to this study by its ClinicalTrials.gov identifier: NCT01000155
|United States, Massachusetts
|Brigham and Women's Hospital
|Boston, Massachusetts, United States, 02115
|Children's Hospital Boston
|Boston, Massachusetts, United States, 02115
|Dana-Farber Cancer Institute
|Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
Dana-Farber Cancer Institute
Brigham and Women's Hospital
Boston Children's Hospital
Merck Sharp & Dohme Corp.
|Principal Investigator:
|Maureen Okam, MD, MPH
|Brigham and Women's Hospital
More Information
Additional Information:
Keywords provided by Maureen Okam, MD, MPH, Dana-Farber Cancer Institute:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 19, 2017
Additional Information:
|Responsible Party:
|Maureen Okam, MD, MPH, Associate Physician, Dana-Farber Cancer Institute
|ClinicalTrials.gov Identifier:
|NCT01000155 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 20, 2009
|Results First Received:
|September 9, 2015
|Last Updated:
|June 21, 2017
Keywords provided by Maureen Okam, MD, MPH, Dana-Farber Cancer Institute:
fetal hemoglobin
HDAC inhibitor
Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn
Antineoplastic Agents
Histone Deacetylase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 19, 2017


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"Points don't win game," the junior swingman said. "It's your defensive effort. When you're active on defense, that's what propels winning."
The No. 7 Hoosiers (17-2 overall, 5-1 in the Big Ten) seek all the propelling they can get as they brace for their season's most grueling stretch.
On Sunday they host Big Ten leader Michigan State (17-3, 6-1), which is ranked No. 13. On Wednesday they travel to rival Purdue (10-9, 3-3), which pushed No. 2 Michigan hard in a Thursday night defeat. On Feb. 2 they host the Wolverines (18-1, 5-1), who are a win at Illinois away from moving to No. 1. The stretch concludes with a road swing to Illinois (15-5, 2-4) and to No. 14 Ohio State (14-4, 4-2).
The key, Sheehey said, is defense.
"When you play defense, when you talk on defense, when you have that complete defensive effort, you won't lose," he said. "And if you do lose, you tip your hat and say, 'next game.' I don't think we did that in our two losses. That's what we're working for."
The results are obvious. Indiana is, in every way, better defensively than last year.
It leads the Big Ten in field goal defense, at 37.9 percent. Last year it was sixth at 44.5 percent.
It is second in three-point defense (28.8 percent) and turnovers forced (13.3). Last year it was seventh in three-point defense (35.5 percent) and 11th in turnovers forced (11.0).
Most importantly, it is fourth in points allowed (61.5) compared to 10th last year (69.6).
"You try to take away some guys' strengths," Sheehey said. "Some guys like to shoot with their left hand, some with their right. When you watch a lot of film, which is what our team does, you find the tendencies of certain players."
IU's defense is driven by championship necessity. Last year the Hoosiers ranked No. 64 in defensive efficiency and lost a Sweet Sixteen track meet to Kentucky. All four Final Four teams ranked in the top 10 in that category.
Yes, coach Tom Crean noticed, which is why he pushes for at least three straight defensive stops. More often than not this season, he gets it.
"It's basketball science," Sheehey said. "If you get a stop, it leads to baskets on the other end."
In other words, defense fuels offense, a theme heard long and often around Cook Hall.
"I think these guys are really understanding that they'll go as far as their defense and their rebounding takes them," Crean said.
That will be especially true against a rugged Michigan State team rounding into physical form behind 6-10 Adreian Payne, 6-9 Derrick Nix and 6-6 Branden Dawson.
Crean is starting to taper, in the short term at least, to ensure his players are fresh for this stretch. He had just a walk-through last Monday and "the shortest practice of the year" (just over an hour) on Tuesday.
"We've got a long, hard stretch coming up," he said. "Every game is going to be an absolute battle. (We wanted) to make sure that we had really good energy and build it over the long haul."
IU's two-game winning streak, Crean added, provides much needed momentum.
"You want to be on a one-game winning streak constantly. Our guys do an excellent job of looking at each game. They've never played with the intention of the next game being on their minds other than the game that they're in.
"Sometimes when you're older and sometimes when you have a lot of expectations on you and you play in a league like this, you can look at the schedule and loose sight. Those teams get beat.
"You can't get too high or too low. You've got to take each game for what it is. If you spend too much time celebrating one or too much time dreading the result of another, you can get in a slide in a hurry in this league. You can't let that happen.
"Our guys have done a great job. The entire focus will be on their improvement and preparing for Michigan State."
More Information
Up nextTipoff: Michigan State at Indiana, 1 p.m. Sunday
Online: For more on Indiana athletics, follow Pete DiPrimio via Twitter at pdiprimio.


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Plans for parking lot, landscaping also submitted
Ukiah Daily Journal
The Ukiah Planning Commission today will consider a plan submitted by Pacific Outfitters for the store's landscaping and outdoor sales events.
According to the staff report prepared for tonight's meeting, Brad Smith of the store at 955 N. State St. is requesting approval of a "final plan" for landscaping and parking, and a permit for outside sales and special events.
The Use Permit approved in 2001 for the site prohibited "outside display, storage or sales of items," but Smith is requesting the following be allowed:
? Daily outside display of canoes and kayaks to be located on the north side of the parking lot within one parking space
? Customer appreciation events in a portion of the parking lot two times per year
? Manufacturer's equipment demonstrations to be located in a portion of the parking lot four to six times a year
? Parking lot sales in a portion of the parking lot twice a year
For the commission's consideration, Planning Department staff drafted conditions of approval for the outdoor sales which include:
? The days and hours of the outdoor sales should be the same as the hours of operation for the store
? No more than one parking space shall be used for outdoor sales and display, and none of the items shall "encroach into landscaping, drive aisles, back-up space or other parking spaces."
? For the special events, factory demonstrations, parking lot sales and customer appreciation days can't be held more than six times a year or more than once a month, and only one special event can be held at one time.
? All the items "shall be removed from the parking area and located indoors overnight," and "overnight storage is prohibited."
The parking and landscaping plan submitted by Smith includes:
? 13 parking spaces with two planter islands at the front of the building;
? Six parking spaces at the rear of the building with no planter islands;
? Eleven shared parking spaces with planter islands at the end of the north parking row and two planter islands between the parking stalls;
? Seven shared parking spaces with planter islands at the end of the south parking row and one planter island between parking stalls.
The landscaping plan shows one tree, an Ornamental Pear, in each planter with no groundcover or shrubs planned.
Staff notes that the Ornamental Pear is not on the city's Master Tree List, and the commission "has the discretion to approve an alternate tree species."
Staff also notes that the redwood chips planned for the planters do not fulfill the requirement that "50 percent of the landscaping be live plantings" and added a condition that shrubs and ground cover be planted in the planters.
The meeting begins tonight at 6 p.m. in the council chambers at 300 Seminary Ave.


text:
Topi, an innovative mobile solution that optimizes networking at conferences, meetings, and other special events, has announced its support to advance the conservation mission of the African Wildlife Foundation (AWF), an international conservation organization headquartered in Kenya.
Hong Kong lawmaker Dr. Hon Elizabeth Quat JP has come to Kenya to help build bridges between China and Africa as part of her campaign to stop the buying of ivory and end the killing of elephants. The trip was organized in partnership with WildAid, Save the Elephants, the African Wildlife Foundation, the Northern Rangelands Trust and Stop Ivory.
Children, conservationists, and local celebrities joined the African Wildlife Foundation and WildlifeDirect on Saturday to celebrate world's largest land mammal ahead of World Elephant Day
Prominent New Zealand businessmen and philanthropists, Dr Gareth Morgan and Sir Stephen Tindall, have teamed up with international supermodel and Patron to Born Free Foundation Rachel Hunter, and the Executive Director of SPCA Auckland, Bob Kerridge, to formally urge the New Zealand Government to consider a complete ban on all ivory trading and to crush the Crown's confiscated ivory stockpile.
Funded by African Wildlife Foundation's mission-based investment company, African Wildlife Capital, Limalimo Lodge is scheduled to open in fall of 2015 and bring benefits to area's wildlife and people


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Focused almost exclusively on Task Force titles with occasional reviews of games from other companies. Later issues are packed with articles on the Starfire and Starfleet Battles game systems.


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Catalog Number: HKM77RSPHHM | Model Number: 17120 | Caliber: .416 Ruger
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Birth Situation Room
Welcome to the "Birth Situation Room," where we gather reports of birth practices around the world. Please take a moment to read the Global Midwifery Council's Mission Statement.
The goal for keeping this resource is to make positive change in birth around the world for motherbaby and society. If you have knowledge of how midwifery or birth are doing in any country or region of a country anywhere in the world please write a letter, report or article for Midwifery Today magazine and the Birth Situation Room.
Map of Earth by NASA's Earth Observatory
How to Use the Birth Situation Room• Select a country from the right with this GMC logo to view reports available from that country:
Highlighted Report
Update on Birth in Hungary
Between 1990 and 2011 existing homebirth practices were alegal. The recent homebirth regulations were introduced in April 2011 and posed a big challenge to midwives to qualify for the necessary licences to attend homebirths. The first licensed midwifery service provider was finally set up in March 2012. Of course many more practicing midwives would need to receive licences if their services are to cover most of the country.
Meanwhile the issue of criminalization—a heritage from those 20 years when homebirth was unregulated—remains a real and constant threat. The internationally famous case of Dr. Ágnes Geréb is a scandalous example of how the judiciary system in Hungary has been unable to follow modern developments in midwifery services. In particular the fact nowadays it is professional boards of midwives who investigate midwifery led birth incidents and not police and criminal prosecution services.
In December, 2010 the European Court of Human Rights passed a judgment in favor of a Hungarian mother declaring that women have their right to choose the place of birth and that it is a safe and private environment for the mother and child.
On May 31 – June 1, in The Hague there will be an international conference based on this decision since it is now an important precedent case for many countries just as the outcome of the Dr. Geréb case will be a major precedent case for the Central and East European region and possibly beyond on this highly contentious issue of the criminalization of midwives.
— Gabriella Nagy
Hungarian Civil Liberties Union Press Release: Victory in Strasbourg for the cause of home birth! (Ternovsky Judgment) (opens a PDF)


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Mail: Southern statues symbolize suppession
Mail: Thanks for helping Aiden
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Fall: Good time to spray musk thistle in rosette stage
Robertson and Delsing re-elected chair, vice chair of NWB
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If you could peel back the layer of the future of North Platte, you might see an international Rail Town attraction under construction, much of it built out of shipping containers, a blue-collar art form that is appearing around the world.
Operating on the promise of a $500,000 matching grant, Rail Town organizer Dave Harrold says it is time to make a vision of Rail Town USA a reality.
The goal is to build a Rail Town attraction along the south side of Interstate-80, between the two North Platte interchanges.
Harrold said North Platte should focus on its railroad heritage and build an attraction that will be noticed by I-80 travelers, who will drive into town to take a good look. He said the success of Rail Fest has proven that people will come from around the world to see the worlds biggest train yard and the area.
As many as 2.4 million travelers pass by North Platte in a year, according to a lengthy feasibility study put together by developer Barry Howard.
Howard has designed impressive projects, including the Rock and Roll Hall of Fame in Cleveland. He also knows trains, as shown by his design of the California Railroad Museum in Sacramento.
Harrold, the ever-enthusiastic railroad fan who built Rail Fest into a consistent major attraction, contacted Howard. Intrigued, Howard came to North Platte a year ago at his own expense to see the possibilities.
Howard saw advantages in developing an attractive theme for North Platte to capture the interest of visitors and entertain them.
Under Howards plan, the Buffalo Bills Scouts Rest Ranch, the Golden Spike, Cody Park, the Wild West Arena and the Lincoln County Museum would all accentuate their railroad features.
Among his concepts:
Scouts Rest Ranch - 19th century rail coach, observation car and caboose, showing the trains that carried settlers and their supplies, and Buffalo Bills Wild West Show.
Downtown - Elevated scale model train operating in a Railroad Square. And, the real trains that travel along Front St. on their way to and from Bailey Yard become a show that never ends for rail fans.
Cody Park kids train rides and a permanent Rail Fest showgrounds, along with the current display in the southeast corner.
Golden Spike a WWII Canteen replica and a Railroad museum.
Much is conceptual but would be logical outgrowths and boost the entire area, Harrold said, even nearby villages
This would help the entire area, he said. For instance, we routinely recommend rail fans take pictures on pedestrian overpasses in Sutherland and Brady. Those are the greatest places in the world, where trains pass by, literally, just a few feet beneath your feet.
Harrold said if North Platte doesnt pursue the opportunity, other towns will, pointing to railroad attractions in Cheyenne and Grand Island.
Those places are not asleep, he said. They will develop, and they are.
North Platte already has something they dont -- the worlds biggest railroad yard.
We need to get going, he said.
Container attraction
The attraction would be built out of shipping containers rectangular steel crates that are used to carry merchandise and supplies around the world.
The jumbo Lego-like containers are being converted to buildings with astonishing results. Architects have adapted them for high-rise apartment blocks in Melbourne, designer penthouse additions in Manhattan and coffee shops in Vancouver.
In Britain, Travelodge used steel containers in two different sizes to create a hotel with 120 rooms and a bar/cafe. The containers were prepared ahead of time in China with plasterboard walls, wiring and plumbing, then were simply bolted together on site. All that was left to install were windows, decoration and furnishings, the company said.
According to preliminary designs, a Rail Town container structure would not be a hotel, but would be home to many things, including an international bazaar of the merchandise shipped through Bailey Yard.
The first installment of Rail Town could be about 700-feet long and about 50 feet wide. At that scale, it could also link to a national center for container art and architecture, in addition to a rail attraction, Harrold said.
In the feasibility study, Howard said the shipping container represents a stunning variety of goods and materials originated from virtually every corner of the globe on newly composed trains heading east and west from the Yard to pass through myriad towns and cities here and abroad, connecting North Platte to all parts of the nation and the world.
The grant is a matching amount and wont be awarded unless $1 million is raised from other sources, Harrold said. He has been talking to potential investors in several states, most recently in Colorado.
This report was first published in the May 8 print edition of the North Platte Bulletin.
Other talkbacks
A less detailed report of this possible attraction, without photos, was posted online May 7 and garnered these talkbacks:
If you take an in-depth look at the Original Town proposal, you will find that it appeals to much, much more than just rail buffs. Yes, rail buffs are part of the demographics, but there are also environmental/green building buffs, art buffs (one of the most frequently heard comments at Rail Fest is admiration for the incredible talent of graffiti artists - these shipping containers will provide ready made - and legal - canvases for their art), architecture buffs, plus those who will simply be captivated by something so unique and conveniently located right off of I-80. The advantage the proposed location has over the Archway is its location BETWEEN two exits only a mile apart. It will be super convenient to exit and return via Halligan Drive to check it out. Unlike the Archway where eastbound the next exit is 9 miles down the road (soon to be rectified), and westbound its over a mile of backtracking. And don't forget that the entire plan calls for a complete mixed-use entertainment development with shopping, dining and entertainment venues. Something North Platte desperately needs. I concur with horseygirl - you go Dave!
-10 Posted by justanopinion - 5/9/2013 12:48:27 PM
Just ask the Archway how being put up next to, or in that case over, the interstate worked out for them. I don't disagree that this town needs something to draw in the tourists. But like the Golden Spike it will appeal to a certain demographic instead of an overall draw. I get that North Platte is proud of it's railroad heritage, but if they want to capitolize on as many tourist dollars as possible it may be time to think about something other than Bailey Yard for a change.
+14 Posted by bigtroubleinlittlenp - 5/9/2013 11:24:55 AM
justmeagain - Have you ever seen a bucket of crabs? In the likely even that you haven't, I'll tell you what happens when one of them begins to find a way to crawl out. As soon as the others realize that one of their own is about to escape to freedom, they reach up with their claws and pull the poor soul back into the bucket with them. Your attitude reminds me of that.
I think this project is a great idea and is an idea whose time has come. Not only will it be along the interstate where it will be seen and easily accessed, it will be a unique attraction that will not only entice people to stop if they are just driving by, it will become a destination.
You go, Dave!
-8 Posted by horseygirl - 5/9/2013 7:26:24 AM
PB, I know containers can be made for good uses, but they are NOT a tourist attraction. They actually are a big waste of money, you do realize thousands of shipping containers get shipped here and never leave? We do not make enough exports to return a fraction of the numbers that arrive. My point was that attempting to make a tourist attraction out of them is a waste of money just like the earlier attempt ole Dave tried to get down by the old depot area. Once the generations die off the trains and the ability to draw interest will also fall. It is just not that interesting to the next generation.
+11 Posted by justmeagain - 5/8/2013 9:47:35 PM
Privatize the profits and publicize the losses. J&J6PK gets slammed again. Bing returned 581mm hits not a new or creative idea. LOL!
+11 Posted by dragracer - 5/8/2013 6:48:08 PM
@ justme agian I disagree completely, a great source of ready made structural material that can EASILY be converted into many things. While I cannot comment on the whole idea using shipping containers as buildings is awesome and cost effective. I have looked into for my own personal use and I believe it is a GREAT idea! Google shipping container homes and buildings and you will be surprised!
-5 Posted by PB - 5/8/2013 5:41:08 AM
shipping containers? Really, someone is grasping at straws. This would be a waste of money.
+2 Posted by justmeagain - 5/7/2013 6:14:37 PM
Flatrock Publishing, Inc.
1300 E 4th St., Suite F
North Platte, NE 69101


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The three well-signposted Elisabeth Paths are pilgrim routes suitable for walking and cycling that retrace the steps taken by St. Elisabeth in medieval times. They start in Frankfurt, Eisenach and Cologne and all have the same destination: St. Elisabeth's Church in Marburg.
St. Elisabeth of Thuringia (1207-1231), to whom a number of miracles have been attributed and who is considered the epitome of charitable work, is one of the most famous saints in the German-speaking world. The Elisabeth Paths, which cover a distance of more than 500km, aim to revive the Christian tradition of following ecumenical pilgrimage routes to St. Elisabeth's Church in Marburg, a town on the Lahn river that first attracted pilgrims in the Middle Ages. The paths use both existing footpaths and newly created trails with a spiritual focus. Today, St. Elisabeth's Church in Marburg remains a vibrant meeting place and houses numerous works of art as well as Elisabeth's empty tomb. A number of stories about St. Elisabeth are still told to this day, particularly in Thuringia, Hessen and Hungary, including the rose miracle. Because of the widespread attestation to miracles, Marburg became a major place of pilgrimage, turning it into a rich and important town. The Elisabeth bower at Creuzburg Castle in western Thuringia, where Elisabeth liked to stay, is open to the public. Landgravine Elisabeth of Thuringia died in 1231 at the age of 24. Soon after, in 1235, she was made a saint owing to her extraordinary altruism. The Elisabeth Paths are spiritual trails where the soul can also wander. Visitors who do not wish to follow the routes alone can join one of the group walks offered at various times during the year.
Kaksi hyödyllistä näppäinyhdistelmää selaimen tekstikoon muuttamiseksi:
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Lisäohjeita saat selaimen valmistajalta napsauttamalla kuvaketta:


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Several days ago, THREEA announced they would cooperate with Japanese Master, Kow Yokoyama for a new series to celebrate 30th anniversary of Maschinen Krieger」. The first product Ma.K. KROTE has met with us. Careful fans may find this robot appeared in a HongKong show in May of this year.
This figure will open for sale on 30th this month.


text: In the aftermath of his epic battle with Piccolo, Goku embarks on an electrifying quest to rescue his fallen friends from the realm of the dead. His perilous journey will take him to the heights of Korin Tower - and beyond - as he searches for Kami, a mystical being with the power to resurrect Shenron and restore the magic of the seven Dragon Balls! But even if Goku succeeds in raising the dead, theres no guarantee hell live long enough to enjoy a reunion with his slain comrades. The World Martial Arts tournament is just around the corner, and an eerily familiar foe known only as Junior wants to teach Goku the true meaning of pain! To survive the tournament and finally earn the title of Worlds Greatest Martial Artist, Goku must train his mind as well as his body in order to complete his amazing transformation from a bushy-tailed boy into a man to be reckoned with! Contains episodes 123-153. Spoken Languages: English, Japanese, English subtitles.Check stock and price


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EPA calls Alcosan's $2 billion sewer system proposal deficientJanuary 31, 2014 11:32 PM
The U.S. Environmental Protection Agency said the region's proposed $2 billion wet weather sewer system improvement plan is deficient and doesn't comply with water quality goals set in a 2008 federal consent order.
But some local officials and community leaders see the EPA ruling, announced late Friday afternoon, as a golden opportunity to add green infrastructure components such as grass roofs, rain gardens, tree planting, rain barrels and bioswales.
The EPA didn't formally disapprove of the plan in the decision, but said it will meet with the Allegheny County Sanitary Authority about the proposal's deficiencies.
According a one-page letter to Alcosan from Jon Capacasa, EPA's water protection division director, the plan, which was years in development, "does not demonstrate that full implementation will result in compliance with all of the requirements of the Consent Decree" by the 2026 deadline.
The letter ended by stating the Department of Justice will contact Alcosan soon with a proposal about how the problems with the plan will be resolved.
Arletta Williams, Alcosan executive director, said she is reviewing the letter and looking forward to further discussions with the Department of Justice and EPA.
"We will take a look at this with the attorneys next week, but right now we're in a holding pattern," Ms. Williams said. "They've given us something to look at and now I am anxiously anticipating our meeting with Justice."
Alcosan submitted a wet weather control plan to EPA a year ago that proposed to capture and treat 79 percent of the region's combined sewer overflows, using only so-called "gray infrastructure" fixes, including construction of bigger collector pipes and three massive underground stormwater storage tunnels that would hold wet-weather flows until they can be pumped through a much-expanded Alcosan treatment facility.
A more extensive $3.6 billion plan proposal would have captured more than 90 percent of that overflow, but was judged too costly for Alcosan's ratepayers, which include the city of Pittsburgh and 83 other municipalities.
According to a written statement issued by David Sternberg, an EPA spokesman, the state Department of Environmental Protection and the Allegheny County Health Department also participated in the plan review and agreed with the noncompliance determination.
Discussions involving the federal, state and local agencies have focused on a "phased approach" to implement the terms of the 2008 federal court-approved consent decree, the statement said.
The statement also said, "EPA does not expect this to delay Alcosan from implementing measures that will ultimately lead to achieving the required water quality goals in its service area."
Alcosan and the municipalities must pursue a "sustainable approach" to achieving water quality improvement goals, the statement said, "including regionalization and a municipal flow reduction program, including green infrastructure where appropriate."
Ms. Williams said Pittsburgh Mayor Bill Peduto, county Executive Rich Fitzgerald and the Alcosan board all support using green infrastructure in the plan.
"We're moving in that direction, and have been moving in that direction," she said.
Earlier this week, Ms. Williams, Mr. Peduto and Mr. Fitzgerald were in Washington, D.C., to discuss the proposed plan with the county's congressional delegation in the office of U.S. Rep. Mike Doyle, D-Forest Hills.
Mr. Peduto said there was agreement that the plan needed more green infrastructure and that the EPA should be lobbied to give Alcosan an extension to improve on its current plan. There were also concerns raised about the affordability of the plan.
Mr. Peduto said he has plans to meet with EPA officials.
"The plan that we submitted is not the plan that we are pursuing," he said. "The plan that we are pursuing is a new plan."
The EPA decision not to approve the plan presents "a big opportunity to look at large scale inclusion of green infrastructure," said Barney Oursler, executive director of Pittsburgh United, a coalition of 13 environmental, union, community and faith organizations that has pushed for green infrastructure in the Alcosan plan.
"I think we have a wide open door now to rethink the whole plan," Mr. Oursler said. "EPA is saying we really need to go back to the drawing board."
He said the Pittsburgh Water and Sewer Authority also has a chance to lead an "integrated approach" to stormwater reduction and treatment that will meet future stormwater quality standards.
Mr. Fitzgerald said the EPA's letter gives Alcosan and its stakeholders an opportunity to pursue green infrastructure, and he's "hopefully optimistic" that that and source reduction get folded into a revised plan.
Don Hopey: email@example.com or 412-263-1983. Kaitlynn Riely and Moriah Balingit contributed. First Published January 31, 2014 5:39 PM


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(2 of 2 customers found this review helpful)
Beautiful Picture
By Susan
from New York
I didn't realize the picture had a built in border that was part of the picture size, so when I had it matted, the overall picture was smaller than I expected.
Bottom Line Yes, I would recommend this to a friend
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Needs a mat with the frame to look good
By CintiBonnie
from Cincinnati, OH
The girl has a very pretty face. However, I'm not too crazy about the print overall. I think that the primary reason is that I'm viewing it too close. It's right by my sink so rather than get a general sense of it, I see every detail. Would have looked much better if I'd added a mat and placed it at a further distance.
Lovely picture
By betsy
from Essex
One of my favourite paintings, so easy to choose the right frame for the picture. Came very quickly and already to hang on the wall
Love the picture!
By Vicwal
from Saline, MI
Details are blurred due to enlargement size. Colors match the colors in the room.Subject matter very appealing to me.I would buy a smaller version to get more clarity of the picture.
Love the picture, excellent
By Patti
from Roselle, Il
My son is an artist and loved this picture, he has pinned it oon his sealing to replicate this beautiful picture
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Growing pains part of the process for Bogaerts, Bradley
BOSTON -- Considering how much praise they've received for their poise, it's easy to forget that Xander Bogaerts is 21 years old and Jackie Bradley Jr. just turned 24. Neither player is perfect, and they've both made some fundamental errors in recent games.
Bogaerts got thrown out trying to steal third in a critical spot in Monday's 7-6 loss to the Orioles and Bradley missed the cutoff man on a throw to the plate.
"I think there's a certain expectancy that some of that might take place," said manager John Farrell, "but what we do with it and how we respond to it is most important. That requires more individual conversation, and that took place yesterday as well as today."
The only way Bogaerts and Bradley are going to learn how to respond to every situation is to go through them.
"You're taking guys that are gaining experience at the Major League level, which is going to be different than any Minor League setting that they've ever been involved in," said Farrell. "The talent is there, the work ethic is there. And yet we've got to ride the ebb and flow a little bit, because of the inexperience, which is fully expected on our part."
Playing two rookies at key positions in the middle of the diamond can be a challenge, but one the Red Sox are fully confident they can work through.
"You're talking about the two positions on the field with respect to outfield or infield that are going to see the most action," said Farrell. "As their learning curve is fairly steep at this point, you may see some things that a veteran player isn't going to show you. That's part of the game and that's part of a young player becoming an everyday big leaguer."
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. Quinn Roberts is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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White Sands, a professional hair care manufacturer rated as one of Hollywood's most requested product lines, is proud to announce their Spring Marcel Curling Iron ($110.00 USD) as the recipient of Best Curling Iron for Essence Magazine's 2011 Beauty Awards!
These innovative and now award-winning curling irons are one of the first in the beauty industry to fuse the Marcel and Spring Load curling iron methods into ONE tool. Utilize the professionalism of a Marcel curling iron to create beautiful waves or switch to the direct control of a Spring Load without the need for multiple irons.
Available in 3 sizes (1″, 1.25″, & 1.33″), this light weight Professional Titanium Iron is the secret to achieve beautifully designed and polished curls. Maintain total styling control with a smart tool providing an instant and even heat with a Digital LED Temperature Setting ranging from 122 – 410°F. As the smoothest surface available for tools, tresses will effortlessly glide over the Titanium barrel for styling free of unwanted tugging, snags, or breakage. This cutting edge material produces the iron's even heat distribution, emitting negative ions to create soft, silky hair.
What I think: This is a great curling iron! I tried the 1.25″ size and it gave me big curls that I brushed out into soft waves — very pretty. I used it on my 6-year-old daughter and created fun barrel curls. She looked so cute! And it was so easy to use. I love that the barrel can rotate, which made it easy when I switched hands and directions of curl, the rotating barrel made the transition easy. It also heated extremely quickly, which is important for curling children's hair — they do not want to wait a long time!
This curling iron is available at fine salons & www.whitesandsproducts.com.


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After all the time and money spent on the recent campaign, we wind up with pretty much the same thing we had ahead of the election. It seems like that energy and money could have been better spent. Now we have to hope that pretty much the same cast of characters doesn't have the same result. Who will blink? Hopefully for the country both sides will or we'll all go over the cliff together with both sides pointing fingers at each other all the way to the bottom.
Already, we are hearing the President and House Speaker claim the same goal but with different approaches. We've heard that before and it didn't work. Neither side can claim any moral high ground in this debate nor any real mandate.
Instead, both sides have failed to lead and left us with huge problems that must be addressed. The election basically gave them another chance to do what they should have done in the first place. Now we wait to see who will lead with action instead of with words.
It looks like the Republican party needs to rethink their approach if they want to win back the White House in the future. They obviously need a candidate who can appeal to a wider portion of the population. Maintaining the conservative base isn't enough to win anymore. Actually, both parties will be challenged to do that in 2016.
Rural America, we have a problem. Once again the map shows a lot of red with some blue spots. Of course, those blue spots are where most of the people are and that's what wins elections. It gets harder each election to feel like a vote in rural America has much impact on the final outcome.
I think our public servants could have done a greater public service by using the money spent on the recent campaign for education, nutrition, debt relief or a number of other areas of need. That would be real change.


text: Well we are looking at now 20 consecutive games without a day off vs the Reds and overall against some very good teams. We get the Nationals for 3 to start if off, but don't see Strausburg...but then we play the Braves, Mets, Yanks, Rockies and Pirates before the month comes to an end. Over those 20 games we have 10 at home, but also will spend 5, yes 5 days in NYC playing 2 vs. the Mets then 3 at NEW Yankee stadium. Come June first where do you see this team being?


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ORLANDO, Fla. Researchers presenting Tuesday at the American Heart Association annual meeting in Orlando, Fla., said that a vaccine could forestall the need to take drugs every day.
"It was a small dose, and the trial was done in a conservative way, but there was not only safety and tolerability—we also had efficacy with blood pressure," said study author Dr. Juerg Nussberger, a professor of medicine at University Hospital of the Canton of Vaud in Lausanne, Switzerland. Nussberger also has an interest in Cytos Biotechnology, which produces the vaccine.
American Heart Association president Dr. Daniel Jones said that there are great benefits to the vaccine, including lack of compliance issues and much more.
Almost one in three Americans suffers from high blood pressure, which increases the risk of stroke, heart disease, heart failure and kidney failure. Part of the problem, researchers said, may be the nuisance for patients following complex medication regimens. Simplicity, researchers noted, produced more benefits.
"The problem is that lifelong, they have to take a pill a day," Nussberger said. "If you can give them a shot, they go home and … later they come back. It would be a good thing."
This new vaccine, known as CYT006-AngQb, works by reducing angiotensin II, a molecule that constricts blood vessels and raises blood pressure. Several existing medications target the same molecule, including ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin receptor blockers).
For this trial, 72 volunteers with mild to moderate high blood pressure were injected with 100 or 300 micrograms (ug) of the vaccine or a placebo at zero, four and 12 weeks from the start of the trial. Volunteers included 65 men and seven women, average age 51.5 years.
After 14 weeks, systolic blood pressure (the top number in a reading) in the high-dose group was reduced by 5.6 mm Hg and diastolic blood pressure (the bottom number) fell by 2.8 mm Hg.
Additionally, the vaccine seemed to diminish the typical blood pressure surge that occurs between 5 a.m. and 8 a.m., which is the time frame when the body is most at risk to a heart attack, stroke, heart and kidney failures, the research pointed out.
Meanwhile, the vaccine also produced a slight increase in renin levels. Renin is an enzyme that is thought to cause inflammation and may play a role in kidney failure.
The vaccine needs further testing, presenters of the data said, to determine if the body has the ability to raise blood pressure if and when needed.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Pharmacy and Medications
Sunscreen SPF
Hi there, what is the highest SPF of sunscreen available today? Is it possible to make a sunscreen with as high SPF as we wish or is there any limitation?
SPF levels describe the amount of UVB protection offered by a sunscreen. Studies have shown that an SPF of 15 blocks 93% of UVB rays, an SPF of 30 blocks nearly 97%, and an SPF of 50 blocks about 98% of UVB rays.
Going much above 50 does not significantly increase the amount of protection. However, since virtually no one applies enough sunscreen, (you should apply a shot glass full at every application) the higher the SPF, the more likely you will get some protection from burning.
There are some companies that offer sunscreens of an SPF of 75 or 90, but how much more protection they provide is controversial. For that reason there is a cap of 50+ for SPFs in Europe and Australia. A proposal for the FDA to do the same in the US is on the table. Since we now know that in addition to being responsible for causing wrinkling, UVA rays found in sunlight also contribute to skin cancer development. That makes it very important that in addition to using an appropriate SPF for your type of skin and activity, you make sure your sunscreen also lists UVA protection.
Tatiana M Oberyszyn, PhD
Associate Professor of Pathology
Associate Professor of Molecular Virology, Immunology & Medical Genetics
College of Medicine
The Ohio State University


text:
OmniActive Health Technologies addresses complex challenges for customers in the dietary supplement, food and beverage space using technology-driven, sustainable solutions with application support within a global regulatory framework. Whether looking for a new ingredient to add to a finished product, or an ingredient solution to enhance an existing ingredient, you will find unmatched innovation at OmniActive.
OmniActive leverages international R&D strengths to deploy an array of state-of-the-art manufacturing technologies in extraction, purification, isolation and delivery of nutritional actives. The company's manufacturing operations are located at multiple sites in India and are cGMP and HACCP system compliant.
OmniActive Health Technologies offers the following products and/or services:
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Vandy's kick was wide right.... Are we sure this wasn't Ray Finkel?
"Nobody wants to play against Tyler Hansbrough NO BODY!" ~ Frank Vogel
"And David put his hand in the bag and took out a stone and slung it. And it struck the Philistine on the head and he fell to the ground. Amen. "


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- Doctors
- Québec
- Montréal
- Family Doctors
- Dr. Navya Mysore
You may also like
Dr. Lise Massé
Ratings for Dr. Navya Mysore
Dr Mysore is my gynecologist. She is a very patient doctor, she carefully listened to me when I was crying in her office when I got bad news about my health, she asked me to come back the week after just to check-up on my mental health... she took the time to answer all my questions. Very professional.
Dr. Mysore is an amazing doctor. She is very intelligent. My husband and I are both patients of hers and we are very pleased with her. She is mature beyond her years.
Dr. Mysore is a wonderful doctor. She is kind, patient, and non-judgmental. She has very strong listening skills and makes you feel welcome in her office. She is also very thorough. She follows up on all blood tests, pap smears, etc. and will send you to a specialist if there is a problem that is not within her skill set. She is the best doctor I have had in 34 years.
Dr. Mysore was very understanding, took her time to listen to what was wrong and directed me to the specialists that were needed. I felt comfortable and at ease when discussing some issues that other medical personnel made light of. Both my children started seeing her and are extremely happy with her care and many friends and family have also praised her dedication and caring attitude towards them.
My children and I have been fortunate enough to have Dr. Mysore as our family doctor for over two years. No matter what problems we come to her with, be it one child's behavioural issues or another's ear infections and broken bones, Dr. Mysore always gives the same high standard of care and her 'bedside manner' is second to none. Having had some medical problems of my own during the past few years, I am so grateful for such a caring and sympathetic doctor who has always been available and who always takes the time to listen and give sound advice, both medically and personally.
Dr Mysore is the best doctor I have had in my 35 years. She is friendly and makes patients feel comfortable, allows us to ask questions and voice concerns no matter how serious or silly. She is knowledgeable and helpful EVERY time i see her. I always feel 100 times better after I leave her office. She is also amazing with my daughter who is 4 years old. I really like that she is that she is thorough and never overlooks potential health issues (refers for bloodwork, testing, xrays..). She is also available by email for emergencies (with a young child, this is amazing and has saved me unnecessary trips to the ER!). Another aspect that i appreciate is her wide range of treatment ideas - not just medications, but knows the importance of healthy eating and exercise, and work-life balance…She is caring and takes the time to discuss, listen, answer questions. I never feel rushed. She is truly an asset to Quebec's medical system! Thanks Dr Mysore! I am SO grateful to have you as my Dr!
Dr.Mysore is amazing she is caring and very smart and punctual. i had some concerns and she answered all my questions and made me feel much better, i walked out of her office feeling 100 times better than when i got there. i reccomended her to my family and friends aswell they will b seeing her soon. Thanks Dr.Mysore.
met with Dr. Mysore in June, and was disappointed with my visit, pab test is about all she was willing to do, didn't really listen to my problems, and never returned a call after my mammogram was completed, oh and $20.00 transport fee ? or if I wanted expedited for $100.00 I would like to think if there was a serious health problem they wouldn't delay in contacting me. I do not recommend this doctor at all !
As her patient I had good experience with Dr. Mysore. She is very caring and easy to talk to. She answered all my questions. She took extraordinary care in conducting physical exam.She has good knowledge and has lot of patience. Very effective doctor. I am really happy to be her patient.
All she can do - take a Pap test. Does not listen or see the obvious. She is not professional. I went to another doctor and she did see the problem even without my words.
Dr. Navya Mysore's Credentials
Facility Affiliations
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Dr. Lise Massé
Top Family Doctors / G.P.s
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My problem is that i have still much anger in my mind.'
How can I change my perception to see that it wasnt his choice to misstreet me?
All beings willl have suffer equally eventually.
That is because I ve been victim for fysical violent actions I know that I ve done my best but how do to that the other persons have tried their best? My anger is on universurse also because;
another questions
person a always talk a lot and have reach the same stage as one that doesnt speak much, is that possible? This is all i can ask about now
I hope to get rid of my anger on universe, is it possible that it takes a hole life to reach almoust totally right perception for one and 40 years for another one?
If its wrong to talk a lot empty talk, cant this person that talk alot understand that he or she isnt almoust to anyones benefit or understand that he or she has done mistake and wants to practice another way thats benefiting other much better? I know that i have done my best cant he or she feel like he or she has done something very wrong and also comes to the conclution of the other way to practice?
How will I know its just a mistake he or she felt that he or she have done while not practice with biggenerating of benefits by he or she´s practice?
How much benefit must my and others practice generate for reach the goal?


text: Collects Daken Dark Wolverine (2010) # 20-23 and What If Wolverine Father (2010 Marvel) #1. Written by Rob Williams. Art by Alessandro Vitti, Matteo Buffagni, Andrea Mutti, Riley Rossmo, Paco Diaz and Greg Tocchini. Cover Art by Giuseppe Camuncoli. The Kingpin of L.A. is revealed at last, as Daken and FBI agent Donna Kiel reach the shocking end of their quest. But with the Heat drug ravaging Daken's mind and body, his outlook on life has been shaken up, and his priorities have changed. With his old business concluded, and suffering through the final stages of his terminal disease, Daken sets out to complete the one goal that has always eluded him: to get revenge on the man he hates most in the world - his father, Wolverine. And if the whole Marvel Universe has to bleed for that to happen, then that's just fine. Hardcover, 112 pages, full color. Cover price $19.99.


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Nakajima becoming more and more comfortable
PHOENIX -- Twice Hiro Nakajima stepped to the plate with runners in scoring position on Sunday, twice getting an opportunity in a key situation to show his employers, his teammates and his fans that, yes, his offensive game is improving.
But by day's end, the infielder was hitless in three at-bats, his spring average down to .194. Still, he stood by his locker with a smile after exiting the game and said that his at-bats are indeed getting better, even though he had nothing to show for it.
"I didn't really feel pressure," Nakajima said through his interpreter. "The first at-bat, there were two outs with second and third, and of course there was the internal thought to get them in, but I feel like my swing, making contact, it's getting better.
"I was able to swing the bat without so much thought process going through my mind. With more practice, my feeling is just starting to get there. It's not a concrete thing, but more of a feeling."
Nakajima's struggles to adapt to the big league game have been well documented, and manager Bob Melvin believes they'll only lessen with more experience.
"It's been a tough time for him," Melvin said, "and whether it's part of being with a new team, the whole culture shock, being in a new league, all these things can play into it, and each guy takes it at his own speed, and there's something to be said of getting acclimated. He's probably not there yet."
This process doesn't happen overnight, and the A's are sensitive to that. Nakajima's teammates are also understanding of the many challenges facing him.
"I think it's tough for him," agreed Eric Sogard, Nakajima's double-play partner on Sunday. "He's starting to get a little more comfortable out there, and I think you'll see him continuing to get more comfortable. He'll do his thing."
Whether that will be by April 1, though, is unclear, and the A's will have to decide if he's ready for regular-season play by then or if they're better off plugging Jed Lowrie into the Opening Day lineup at shortstop.
Ask Nakajima if he'll have reached that necessary comfort level by then, and he doesn't hesitate.
"Yes," he said. "I definitely think so."
Jane Lee is a reporter for MLB.com. Read her blog, Major Lee-ague, and follow her on Twitter @JaneMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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Mr. Needleman stated, "For the purpose of emphasizing the core essence of what Aptuit represents to clients, we examined the many ways that we could concisely express just what we stand for. We want our clients to know that it is our uncommon expertise that gives them the assurance of exceptional results."
Mr. Needleman explained that there's a real point of difference between Aptuit and other CROs; namely, that Aptuit combines all the capabilities of a CRO with the efficiency of an integrated, large pharma R&D engine. "From drug discovery to drug development, our services coalesce to provide an integrated, collaborative response to advancing the success of our client's molecule. Our responsiveness includes access as needed to the expertise of a vast number of scientists at our key locations around the world. These scientists have had experience in working with emerging biotechs as well as large pharmaceutical companies and many of them have worked within a large pharma environment for a substantial number of years. Significantly, they have expertise across a range of therapeutic areas, the same areas of discovery and development that challenge our clients."
Mr. Needleman stressed that when Aptuit teams of multidisciplinary, expert scientists collaborate in integrated efforts from a single Aptuit site, or coordinate their knowledge among several sites, successful results are predictable.
"What's not predictable in any project are the unexpected findings that may surface that threaten to forestall or interfere with the process. It is at these junctures that clients experience Aptuit's 'uncommon expertise' at its fullest since we operate in a spirit of openness and transparency. Our goal is to ensure that clients are never in the dark about what's happening and what the impact may be, which we can mitigate because we employ a flexible strategy. Aptuit clients are aware of what's going on – under the leadership of project management and through our overriding culture of service that goes above and beyond. They experience what we do to identify obstacles early on; they see firsthand how our commitment to straightforward and honest communications is a major part of ensuring exceptional results," concluded Mr. Needleman.
For more information, please contact Maria Garvey, Delfino Marketing at 914-747-1400 or firstname.lastname@example.com.
Aptuit LLC provides the most complete set of integrated early to mid-phase development services in the pharmaceutical industry. Drug Design & Discovery, Preclinical Biosciences, API Development and Manufacture, Solid State Chemistry, Sterile Fill Finish & Formulation Development, Oral Dosage Form Development & Manufacture, Clinical Sciences, Consulting and Aptuit INDiGOÒ (a program that accelerates drug development) are offered as stand alone or integrated services. Fully integrated drug discovery & development services are available from a single site at The Aptuit Center for Drug Discovery & Development in Verona, Italy. The company maintains five global facilities with approximately 800 employees in Europe and the United States, and has a strategic relationship with Laurus Labs in India. Aptuit LLC is partnered with Welsh, Carson, Anderson & Stowe, one of the world's leading private equity investors.
For more information about Aptuit, visit www.aptuit.com


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We are accredited by the Association of Avian Rescue Organizations (AARO) and licensed by the Illinois Department of Agriculture, Bureau of Animal Welfare to provide for adoptions. We are also a member of the Society of Animal Welfare Administrators.
Thank You!
Your message has been sent to a Refuge for Saving the Wildlife, Incorporated.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


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Large capacity widemouth tool organizer with rubber base keeps tools organized and dry. Widemouth tool bag features 52 pockets; 38 exterior, 14 interior and an adjustable internal divider. The molded rubber base provides a solid foundation and moisture protection. Easily handle heavy loads with the bio-curved padded shoulder strap and carry handle. Includes an outside tape loop and strapping for level or long tools and a detachable cell phone holder, parts organizer, a pouch for small supplies and a caribiner. Ballistic poly construction holds up in tough conditions. Measures 18-1/2"Lx11-1/2"Wx15"H. Imported.


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SU-students and Campus-Wide Conflict: Bridging the Divide Through the Use of Theatre as a Community Forum
Natalie Goodnow
Faculty Sponsor: Dr. Sergio Costola
What are the differences between a debate and a dialogue? What are the differences between communicating through email as opposed to communicating in person? What repercussions do the answers to these questions have on Southwestern students? Do our "email wars" help to build a sense of community, or are they destructive? What happens when the topic of conversation shifts from global and national events to ones that have occurred on our own campus? What kind of power do our words have to harm other people? Do we wield that power responsibly?
These are the kinds of questions that su-students: email wars asks. su-students: email wars is a play that consists of imaginative dramatizations and interpretations of the heated debates that took place on the su-students email listserv during the Fall 2005 semester. It will be performed on April 4 and 5, 2006, followed by a facilitated dialogue session and community forum which will allow Southwestern students the opportunity to discuss, in person, the issues addressed in the performance.
The dramatizations of the emails have been collectively created by a company of over twenty Southwestern students. In addition to creatively addressing the need for healthy communication about difficult issues, the project also offers these students the opportunity to explore alternative models of collaboration and leadership in theatre-making.
Thus far, our discussions of these issues in our rehearsals have yielded some of the most honest, difficult, but healthy conversations that I have ever had the privilege of being a part of in all my life. I look forward to sharing these experiences with our audiences.


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De La Torre to get his chance in big leagues
BOSTON -- The recent injuries to Boston's bullpen have created an opportunity for Jose De La Torre, who had his contract selected from Triple-A Pawtucket for Thursday's game against the Twins.
De La Torre was acquired from the Indians on July 24, 2012 in a trade for Brent Lillibridge.
This is the first time the 27-year-old De La Torre has been on a Major League roster.
"I wasn't expecting it, but I'm just real excited at being here and happy I got the opportunity," De La Torre said.
He pitched for Team Puerto Rico in the World Baseball Classic in March.
"I think it opened some eyes. I think it helped me pitching on a bigger stage and doing what I did. I think it helped me a lot," De La Torre said.
How will De La Torre be used by manager John Farrell?
"Low leverage innings right now," said Farrell. "He's been stretched out to a couple of innings while at Pawtucket. Very good breaking ball that he showed us in Spring Training. He's got the ability to get an above average fastball at times. So we'll pick our spots for him. I'm not going to say he's just a strict matchup guy. We needed the arm, obviously, in the bullpen."
De La Torre posted a 1.56 ERA in 17 1/3 innings for Pawtucket, holding opposing hitters to a .089 batting average (5-for-56). He allowed only one knock over his last 11 2/3 frames.
Ian Browne is a reporter for MLB.com. Read his blog, Brownie Points, and follow him on Twitter @IanMBrowne. This story was not subject to the approval of Major League Baseball or its clubs.


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Staff at Airedale Hospital have won national and international recognition for the quality of their work.
Nurse Jane Pearce has been awarded a certificate from the Multiple Sclerosis Nurses International Certification Board, while Nona Toothill, Airedale's urology specialist, has been shortlisted for a national nursing award.
Mrs Pearce, 50, has gained her certificate after passing a stringent examination for all nurses worldwide who provide MS care.
Only nine people each year sit the exam, which is part-funded by the International Organisation of MS Nurses and the UK Multiple Sclerosis Specialist Nurses Association.
Mrs Pearce, who has been an MS specialist nurse for eight years and lives in Haworth, said: "This highly valued qualification has allowed me to improve my practice, increase my knowledge and encouraged me to develop both personally and professional expertise in my field, which will ultimately benefit my patients."
Mrs Toothill, 45, from Cowling, is one of three people in the country competing for the Urology Nurse of the Year category of the British Journal of Nursing Awards 2014. She will take part in an awards ceremony in London on March 21.
She works with staff in nursing and residential homes and supports urologists in their clinics where patients with prostate problems are assessed and offered help.
Mrs Toothill said: "I'm delighted to be shortlisted, especially as we were told there was a lot of competition.
"My role is quite challenging. We do our best to support urology patients, offer an efficient and friendly service and help make life as easy as possible for both them and their families."


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Posted 7 years ago
(2 items)
trying to get a value on this. Story I have gotten was it came from the original levi outlet in houston texas. I have searched the internet and have not found a register that looks like this one so I have not been able to get an idea of what it is worth. Thanks


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Dr. Oliver Wendell Holmes
Dr. Oliver Wendell Holmes
Phillips Academy
Oliver Wendell Holmes was a member of the Class of 1825 sent to school here by his father Abiel, a trustee of the Academy from 1809 through 1837. Holmes went on to become a physician, professor, author and inventor. He was also the father of Oliver Wendell Holmes, Jr. the Supreme Court Justice and Civil War veteran. Holmes went in search of his son after hearing he had been wounded through the neck at Keedysville. His essay "My Hunt after the Captain" relates the experience. It was the third wound the young Holmes had received during the war and the most serious.
Phillips Academy -- Alumni and Alumnae
Holmes, Oliver Wendell 1809-1894
Citation :
"Dr. Oliver Wendell Holmes ," in NOBLE Digital Heritage, Item #15497, http://heritage.noblenet.org/items/show/15497 (accessed September 20, 2017).


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HAMPSHIRE and Isle of Wight Air Ambulance bosses are appealing to the public not to throw out unwanted Christmas gifts.
The charity is welcoming people's unwanted clothing, shoes or textiles to help raise much needed cash to keep the two counties flying medics in the air.
Cash from recycled textiles is the charity's second large resource of income.
Bosses are now urging people with unwanted festive decorated jumpers and socks to bag them up and dump them in one of the charity's yellow textile bins at Romsey Bus Station and at Lockerley and East Dean War Memorial Hall and other sites across Hampshire.
Any other unwanted or discarded clothing is also welcome says the charity adding that even worn out shoes can go in the textile banks.
Hampshire and Isle of Wight Air Ambulance chief executive John Perry said: "The majority of the textile donations we receive at this time of year have come from wardrobe clear-outs. With clothing banks at recycling sites across our region, there are plenty of places for people to take last season's garments and put them to a worthwhile cause."
The charity operates its textile banks in conjunction with Bag It Up Ltd and a full list of recycling bank sites can be found at biugroup.co.uk.


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View: City council agenda
UPLAND – City Manager Stephen Dunn has been authorized to evaluate potential cuts and revenue increases to address the city's dwindling fiscal condition.
Council members on Monday – with the exception of Councilman Gino Filippi – gave Dunn the ability to move forward on a list of long-term recommendations to help restore reserves and free up money in the general fund.
"I have to say, these are just recommendations. There's nothing here I'm saying I absolutely want to do," Dunn said. "I want to dig into what is driving those expenses and see if there's a way of doing something different that could save ourselves some money."
Dunn said he will begin to bring his final recommendations back to council members in January.
"I would start doing that the first part of January 2013, only because in the last week or so, since we met on Nov. 7, there has been some movement with labor and I'd like to see where that goes," he said.
Dunn presented the recommendations to council members at a Nov. 7 special meeting.
The council had asked Dunn to return with more information on long-term recommendations, but agreed to short-term suggestions that include making $229,000 in cuts and transferring $250,000 from the gas-tax fund if necessary.
The city's reserves have fallen from a projected $4.2 million to $932,000.
The Animal Services, Self-Insurance and General Capital Improvements funds are operating with a $5.3 million deficit to the city's General Fund.
The city also needs $3 million to restore their reserves to 10 percent of their expenditures.
There are areas of the budget that are under funded or not funded such as vehicle replacement, post-employment benefits, street repairs, sidewalk repairs and alley repairs.
City officials are asking employees to pay their portion of their pension and other concessions.
Filippi voted against the recommendations because he wants consistency on the amount of savings needed, which is a minimum of $2 million.
"I was under the understanding that if the employees came together cumulatively we'd be close to our target, which the target I understand is $2 million and the employees coming together on their benefits would be close to $1.6 million," Filippi said.
"Then, (Monday) he shared with me that he really needs $4 million, so I just want consistency. I want as much consistency in the numbers as I can get before I feel confident about voting a certain way."
The long-term recommendations include exploring alternative ways to provide various city services.
They include:
Other long-term recommendations are:
Upland City Manager Stephen Dunn will look into several revenue options to help the city's finances.
They include:
Dunn and city staff will also look into creating one-time revenue to be used toward the reserves by selling property, which could result in an additional $350,000, or selling cell tower leases to gain $1.7 million, but will result in the loss of $150,000.
Reach Sandra via email, call her at 909-483-8555, or find her on Twitter @UplandNow .


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A couple of drunk idiots in the UK picked a fight with a couple of cross-dressers.
There's one thing they didn't know, though: The two men dressed in drag were also professional cage fighters. From the video, it looks like 3 men wandering around, picking a fight with some people... Later, they see the cross-dressers, and 2 of the 3 men try to get in their faces. The cross-dressing man, one of 'em, it looks like he just dropped 'em both with one punch each. Then they stumbled off. The two attackers were later arrested by police.
Article and video is here:
http://www.asylum.co.uk/2009/10/07/thug ... -fighters/