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Obama's Motives
When Caroline Randall Williams practically begs Barack Obama to speak out on the state of American politics, she speaks for millions of distraught Democrats. "We need your voice," she writes in an op-ed for the New York Times. "There is not a saner, more trustworthy opinion that many of us would rather hear."
Williams confesses to a sense of "panic," and Donald Trump's penchant for divisive racial agitation surely hasn't helped ease her sense of dread. But by her own admission, her nervous condition is a result of less sober and rational voices on the left sucking up all the oxygen. Her anxiety peaked, she reveals, when people like Alan Dershowitz and Maxine Waters warned her that a constitutional crisis is just around the corner.
The young author and columnist, whose moving appeal to the former president resonated with many apprehensive Democrats, will soon get her wish. Barack Obama will not languish in the shadows in his post presidency. Indeed, he cannot afford to, but not because of an acute civic crisis looming forever just over the horizon. He has an image to rehabilitate.
The 44th President left his party in tatters. Over 1,000 Democratic lawmakers lost their seats to Republicans between 2009 and 2017. We're all familiar with the timeline of events. The House fell in 2010; the Senate in 2014. Democrats entered 2009 with 31 governorships. Today, they're reduced to just 15. Half the Union is governed entirely by the Republican Party. But it's at the legislative level where the damage to the Democratic brand becomes most obvious. In 2009, 62 of 99 legislative chambers were dominated by Democrats. Today, Democrats control just 31 state-level chambers.
This was Barack Obama's chief regret, although he did not say so precisely. The decimation of the Democratic "farm team," from which the youngest and hungriest candidates for federal office are drawn, has handicapped the party. In the autumn of 2016, Obama sought to address this dubious legacy by getting right down to the state level. He toured the country endorsing 150 legislative candidates and campaigning on their behalf. The result? The Democratic Party's decline continued largely unabated. In the end, Obama's near total repudiation is self-evident in the image of his successor.
Does Williams know that Barack Obama is as much to blame as Donald Trump for her trauma? She is beset by the voices of doom and panic, in part, because hundreds of center-left Democrats who are less prone to apocalyptic rhetoric find themselves in the private sector today. She hungers for a more reasonable set of Democrats who might reassure her that the system of checks and balances that prevent a demagogic figure from doing irreparable damage to the republic are working (which they are). Obama might be keen to play that role, but he would be doing his fellow Democrats yet another disservice.
All Donald Trump wants for Christmas is a foil onto whom he can project his frustrations that would also unite the GOP behind him. Congressional Democrats are weak and factious. Political media is disliked by Republicans, but they are an unsatisfying opponent ("media" won't be on the ballot next November). Congressional Republicans maintain their individual constituencies, even if they are mistrusted by the Republican base in the aggregate. And Donald Trump seems disinclined to rally the country against a real foreign adversary.
Barack Obama plans to remerge into the national political scene along with Hillary Clinton, but both plan to do so with as much delicacy as possible, insofar as they can thread that needle, if only to avoid giving Trump what he wants. No matter how they make their move, Donald Trump will exploit their reappearance onto the political scene and reenergize the largely dispirited core GOP coalition.
Williams's fear is honest, and her plea is heartfelt. That's why she deserves to hear the unpleasant truth: Barack Obama is as accountable for her anxiety as anyone. The former president's resurfacing this fall is as likely to exacerbate those symptoms as it is to alleviate them. Given that fact, it's worth pondering whether Obama really is hitting the trail this fall entirely out of an abiding sense of moral and civic obligation. That's surely part of what motivates the former president, but it's not the only thing.
Obama's Motives
Must-Reads from Magazine
Trump Tries a New Tack on the Peace Process
The definition of sanity.
President Donald Trump's address to the UN last week received considerable attention for what he actually said. No less interesting, however, is what he didn't say. The speech contained zero mention of the Palestinians, zero mention of their conflict with Israel, and zero mention of the peace process Trump has been trying to revive.
This omission isn't unprecedented, but it is unusual; most U.S. presidents have included the Israeli-Palestinian issue in their annual UN addresses. And it seems especially surprising for a president who has repeatedly declared Israeli-Palestinian peace to be one of his major foreign policy goals.
Yet the omission is perfectly consistent with Trump's approach to the peace process to date, which has differed markedly from that of all his predecessors in one crucial regard: He appears to be trying to apply serious pressure to the Palestinians rather than only to Israel.
Take, for instance, his administration's consistent refusal to say that the goal of the peace process is a two-state solution. Since efforts to achieve a two-state solution have repeatedly failed for almost 25 years now, it makes obvious sense for anyone who's serious about trying to solve the conflict to at least consider whether this is really the most workable option. But even if, as seems likely, the administration actually does believe in the two-state solution, refusing to publicly commit to it serves an important purpose.
That's because insisting that the end goal be a Palestinian state is a major concession to the Palestinians—something that has unfortunately been forgotten over the last quarter century. After all, throughout Israel's first 45 years of existence, there was almost wall-to-wall consensus among Israelis that a Palestinian state would endanger their country. Even the 1993 Oslo Accord included no mention of Palestinian statehood, and the man who signed it, Prime Minister Yitzhak Rabin, asserted in his final address to the Knesset in 1995 that he envisioned a "Palestinian entity . . . which is less than a state."
Yet to date, this significant concession to the Palestinians has never been accompanied by a corresponding Palestinian concession to Israel. Though the Palestinians insist on a Palestinian nation-state, they still refuse to accept a Jewish nation-state alongside it. Instead, they demand that millions of descendants of Palestinian refugees be allowed to relocate to Israel, turning it into a binational state.
Nor has this major concession to the Palestinians been accompanied by a corresponding international concession to Israel. The European Union, for instance, repeatedly makes very specific demands of Israel, insisting that it accept a Palestinian state based on the 1967 lines and Jerusalem as the capital of two states. But the EU has never demanded that the Palestinians accept a Jewish state or give up their idea of relocating millions of Palestinians to Israel. Instead, it merely calls for an unspecified "just, fair, agreed and realistic solution" to the Palestinian refugee problem, which the Palestinians–who view flooding Israel with millions of Palestinians as the only "just" solution–can easily interpret as support for their position.
In short, until Trump came along, the Palestinians won this major concession for free. Now, by refusing to declare a two-state solution as his goal, he has essentially told the Palestinians, for the first time in the history of the peace process, that every concession they previously pocketed is reversible unless and until they actually sign a deal. In other words, for the first time in the history of the peace process, he has told the Palestinians they have something to lose by intransigence. And if they want to reinstate America's commitment to a Palestinian state, they will have to give something in exchange.
The same goes for Trump's refusal even to mention the Palestinians in his UN speech. When former Secretary of State John Kerry repeatedly insisted that the Palestinian-Israeli conflict is the world's most important foreign policy problem (a message routinely echoed by European diplomats), that gave the Palestinians tremendous leverage. Since they have always been the more intransigent side, the easiest path for any broker to follow is to simply support more and more Palestinian demands without requiring any substantive Palestinian concessions in return and then try to pressure Israel into agreeing. Thus, if world leaders are desperate to resolve the conflict, they will naturally tend to take that easy path in the hope of producing quick "achievements," which is, in fact, what has happened over the last two decades. The result is that the Palestinians have concluded they can keep getting more simply by continuing to say no.
In his UN speech, Trump sent the opposite message: There are a lot of important foreign policy issues, like North Korea and Iran, and the Palestinian issue is so trivial by comparison that it doesn't even merit a mention. In other words, though Trump would like to broker a peace deal, it isn't necessary for America's own interests. And therefore, it's only worth investing time and effort in it if Palestinians and Israelis are both actually ready to deal, which means the Palestinians will have to be ready to finally make some concessions.
There are ample grounds for skepticism about whether Trump's approach will work; based on the accumulated evidence of the last quarter century, I consider it far more likely that the Palestinians simply aren't interested in signing a deal on any terms. Nevertheless, there is a plausible alternative theory. Perhaps Palestinians keep saying no simply because doing so has proven effective in securing more concessions. And if that's the case, then reversing this perverse set of incentives by telling them they stand to lose from intransigence rather than gain by it could actually be effective.
Whether he succeeds or fails, Trump deserves credit for trying something new. Given the failure of his predecessors to achieve peace, only State Department bureaucrats could imagine that doing the same thing one more time would somehow produce different results.
Trump is Pavlov and We Are The Dogs
Podcast: Trump starts a fight, but will he win it?
The first COMMENTARY podcast of the week finds us (me, Abe Greenwald, and Noah Rothman) discussing the weekend of knee-taking and Trump-tweeting about patriotism and the NFL and blah blah blah while North Korea threatens hydrogen bomb-testing and Puerto Rico reverts to a state of nature. And we enjoy the decline and fall of Valerie Plame. Give a listen.
Don't forget to subscribe to our podcast on iTunes.
Donald Trump, Cultural Wrecking Ball
What is he winning exactly?
Conservative political analysts seem so wrapped up in the matter of whether or not Donald Trump can, no one has given much thought to whether he should.
The latest national scandal, which will surely be as fleeting as its myriad predecessors, was whipped up by the president on a whim while he fed off the adoration of his fans at an Alabama political rally over the weekend. "Wouldn't you love to see one of the NFL owners when somebody disrespects the flag to say get that sonofabitch off the field?" the president boomed. The crowd roared, Trump absorbed the positive feedback, and the nation's opinion makers on the right and the left responded to the president's goading with Pavlovian predictability. Trump so enjoyed the quivering of the raw nerve he touched that he spent the following morning attacking a variety of African-American professional athletes and disinviting them to the White House on, ostensibly, patriotic grounds.
What urgent controversy was the president addressing? Former San Francisco 49ers quarterback Colin Kaepernick, who became the subject of national scrutiny when he opted to protest police violence targeting African-Americans by kneeling for the national anthem, hasn't played in the National Football League this year. He became a free agent when his contract elapsed in March, and another team did not sign him.
Isolated episodes of questionable police violence against African-Americans persist, like the tragic 2016 murder of Philando Castile—a case in which moral justice, as opposed to the purely procedural variety, has proven elusive. So, too, do contentions that some police departments are eager to cover that violence up, like the three Chicago officers indicated for conspiring to hide evidence related to the fatal 2014 shooting of Laquan McDonald. But were there mass Black Lives Matter protests paralyzing American urban centers when the president made his remarks, as there had been in years past? No.
The president decided to ignite a controversy, and the nation's culturally conservative commentators—even those sympathetic to claims that justice is routinely denied blacks in over-policed portions of the country—proceeded to deem Trump the winner of this manufactured kerfuffle. National Review's Rich Lowry noted that Trump's antipathy toward Kaepernick and those in professional sports who sympathize with his tactics called his agitation indicative of a "gut-level political savvy." The Resurgent's Erick Erickson agreed: "Donald Trump Did Not Start This. But He Will Finish It. And He Will Win."
As a purely dispassionate political analysis, these assertions have undeniable merit. The majority of the country does not see the American flag or the national anthem of the United States as symbols of oppression, and a majority in 2016 did not sympathize with those who "take the knee." They might think that African-Americans, in particular, have a legitimate claim to make against the state, but see the broad brush with which some protesters tar the country as unfair to a nation that has sacrificed much to secure freedom and egalitarianism for both its citizens and the whole of mankind. And perhaps white Americans who resent these protesters see Trump as a medium through which they can communicate this point of view to a cultural media establishment that rejects it in its entirety and with overwhelming, righteous passion.
But is Trump winning anything beyond a likely short-lived reprieve from a focus on the fact that he has yet to secure a legislative achievement that will outlast his presidency? No. He has, instead, expertly torn asunder existing fissures in the country, exploiting them for his own temporary political gain. Is Trump as the avatar of true patriotism, self-sacrifice, and national healing toward a racial consensus? Is he going to truly advance the goals of his so-called "silent majority?" Or is he going to increase tensions? Has he brought the nation together, or did he simply embitter white Americans and alienate their black counterparts? Is this leadership? Is it conservative? The right once knew the answers to these questions, but it took a Democrat to make them see it.
To call Trump's crusade or the campaign of kneeling for the Star Spangled Banner a culture war annoys activists on both sides. For the kneelers, they are protesting state-sponsored bloodletting; their cause is existential. For those who stand, the very definition of their nation is at stake, and the security it provides them and their families with it. But no one so protested when it was Barack Obama serving on the front lines of what most agreed was a culture war.
In 2014, along with making a point of only calling on women during a press conference and executing a variety of legally dubious (and doomed) executive actions on immigration, Obama indulged his liberal critics by finally speaking out more boldly on the issue of race in popular media venues like Black Entertainment Television. Following the 2014 killing of Eric Garner by New York City police in a chokehold after he tried to sell loosie cigarettes, the president went out of his way to endorse the actions of professional athletes who were disgusted by the injustice.
"You know, I think LeBron [James] did the right thing," Barack Obama told People Magazine regarding the NBA star's decision to wear a t-shirt bearing Garner's last reported words: "I can't breathe." Obama compared James to the icons of led the fight for civil rights. "We forget the role that Muhammad Ali, Arthur Ashe, and Bill Russell played in raising consciousness," he insisted. "I'd like to see more athletes do that—not just around this issue, but around a range of issues."
Anti-Trump activists who are deservedly incensed by Trump's behavior will claim that there is no comparison between these two assertions, but that's how precedents work. Those who inherit them build upon them in ways that are not always optimal or prudent. That's why presidents should be cautious about setting them. Barack Obama spoke more eloquently and with greater delicacy on the issue of race than Trump is capable of or interested in mimicking, but the 44th President did not heal divisions with these comments. There was no legislative remedy available to Obama to address the issue of excessive local policing targeting minorities. Because such behavior violates existing laws, it is a matter only of enforcement. That's why Obama's supporters demanded only that the president speak his mind on race and discrimination, and were largely satisfied when he did.
Culture wars beget a response because they almost never end—not totally. It's too much to expect those who cheered on Obama's decision to wade into contentious cultural matters to engage in any introspection, but conservatives should be expected to recall the admonitions they once issued not all that long ago. The president's words matter a great deal, and he should be supremely careful about deploying them. They can and often do yield more harm than good.
London Is Closed to Competition
Competition is a scary thing.
Soon after last summer's U.K. vote to leave the European Union, London Mayor Sadiq Khan launched a publicity campaign to reassure investors that his city would remain a dynamic, global hub after Brexit. "London Is Open" was the slogan, and it was supposed to "show the world that London remains entrepreneurial, international and full of creativity and possibility."
So much for that. Friday's decision by the city's transport regulator not to renew Uber's license suggests that Khan's London is closed to competition and in thrall to local special interests.
The regulator, Transport for London, said the decision was based on Uber's alleged lack of corporate responsibility in a variety of areas, particularly public safety. Yet there is no Uber-driven safety crisis in London. If Uber has made missteps, as any company might, putting 40,000 drivers out of work and inconveniencing 3.5 million London riders is a terrible way to respond.
Public safety is a pretext. The Uber ban comes after years of lobbying–and strikes and bullying–by the city's black-taxi cartel. Before Uber came along, the industry's high barriers to entry shielded black taxis from competition. It takes tens of thousands of pounds to buy a black cab and years to acquire "the knowledge"–drivers' vaunted ability to memorize and instantly recall the best way to any destination.
The advent of GPS and ride-sharing meant that having the knowledge wasn't all that special. Rather than try to outcompete Uber by offering better prices and service, the black taxis continued to charge outrageously overpriced fares. And they sought to defeat ride-sharing politically. Now they have succeeded. The losers are riders who used ride-sharing for fast, reliable, and accountable service.
The first black taxi I ever took, in 2014, took me from Heathrow Airport to Euston, in central London. It cost nearly £100 (or $170 at the time). That taught me early on to rely on my Uber app, and since then I have taken hundreds of rides. Defenders of the ban point to pre-booked minicab services and the like that often cost less or about the same as Uber. Yet none of those services offer the speed, ease, and pickup accuracy that Uber does. Black taxis don't routinely serve many low-income neighborhoods, moreover, whereas Uber works wherever people have smartphones.
If you leave a personal item in a black cab and pay cash, there is no way to recover it. With Uber and similar apps, you can immediately track down your driver, and he will usually return the item to you within hours. As for safety and sexual assault: Rachel Cunliffe pointed out in the Spectator that Uber is the far safer option for female riders, who don't have to trawl the streets looking for taxis. Every ride and every driver is tracked.
The Uber ban is the triumph of protectionism over innovation and clientelism over consumer choice. London is not open.
The Case for Kurdistan
A boon to America, the region, and the world.
The Kurds have been a people without a state for centuries. Monday's independence referendum in northern Iraq's Kurdish zone is an important step toward rectifying this historic injustice, and I believe the U.S. is making a grave mistake by opposing the vote.
The Trump administration announced its displeasure in a September 15 statement, noting that the referendum "is distracting from the effort to defeat ISIS and stabilize the liberated areas." It added: "Holding the referendum in disputed areas is particularly provocative and destabilizing." The Kurdistan Regional Government (KRG), the White House said, should work out its differences with Baghdad through dialogue.
Not now, go away, in other words. The statement reflected the sort of rigid adherence to Washington dogma that too often prevents America from seizing the opportunities presented by the tectonic shifts in the Middle East. The Trump administration failed even to nod at Kurdish aspirations, or offer an alternative timeline if the current moment is too inconvenient. This was an unnecessary slap when there are compelling moral and strategic reasons for creating a Kurdish state in northern Iraq sooner than later.
The Kurds got by far the worst treatment during the decades of Baathist rule in Iraq. Saddam Hussein ethnically cleansed tens of thousands of them in the 1970s. Then, in the closing days of the Iran-Iraq War, he set out to destroy the Kurdish community. The regime fired chemical weapons at Kurdish civilians, summarily executed men and boys, and sent entire villages to concentration camps.
President George H.W. Bush's decision to impose a no-fly zone in 1991 granted Iraqi Kurds protection against Saddam's depredations and a measure of autonomy. The Kurds used the opening, and the one provided by the 2003 invasion, to develop institutions of self-government. Iraqi Kurds constitute a coherent nation. They stand out in a region full of non-nation-states in various stages of disintegration. Kurds speak a common language, albeit with regional variations. Most are Sunni Muslims, though there are Christians and even a very few Jews among them, as well. They have deep historical ties to their territory. Their culture sets them apart, visibly, from their neighbors. They have distinct national institutions. And they already enjoy quasi-state recognition in the corridors of power in Europe, the Middle East, and beyond.
Iraqi Kurds, moreover, share what Douglas Feith has described as the key subjective factor in nationhood: a "type of fellow feeling" that is "an extension of the affection people tend to have for their family members." Whatever their tribal differences—and these are real—Kurds living in Erbil or Dohuk today look upon other Kurds, not Iraqis, as their true compatriots. The bonds of Kurdish sympathy are much stronger and more enduring than those of Iraqi nationalism, if the latter means much at all.
Taken together, these factors mean that Iraqi Kurds are ripe for statehood. The Arabs have 22 states, and the Turks, Iranians, and Jews each have one—so why shouldn't the Kurds enjoy statehood? There is no good answer to this question.
Then, too, Iraqi Kurdistan is vibrant and free. In Erbil today, within an hour's drive from what used to be the second capital of the ISIS "caliphate," you can enjoy a beer, surf a largely unrestricted Internet, and criticize the government without having to fear death squads. You won't hear chants of "Death to America" or "Death to Israel" on the streets. There is corruption in the Kurdistan Regional Government, to be sure, and a degree of political nepotism that would make Jared Kushner and Ivanka Trump blush. But by regional standards, KRG governance is more than acceptable.
An independent Kurdistan, moreover, will bear strategic fruit for the U.S. It could serve as a counterweight, however small, to Iranian hegemony. KRG leaders have taken a moderate, pragmatic line with all of their neighbors. That is wise policy, given the region's size and strength relative to the likes of Iran and Turkey. Even so, the introduction of a new, fully sovereign Kurdish actor would interrupt Tehran's so-called Shiite crescent stretching from Sanaa to Beirut. Today Iraq is trapped in the crescent. An independent Kurdistan wouldn't be. It would irk the mullahs still more if this new state turned out to be a democratic success story. Conversely, by blocking Kurdish aspirations, the U.S. is putting itself in the same camp as Iran.
Most important, friendship should mean something. Iraqi Kurdish forces fought valiantly alongside the U.S.-led anti-ISIS coalition. When the jihadist army seemed invincible, it was Kurdish fighters who stopped its march across Iraq (and Syria). As Kurdish intelligence chief Masrour Barzani told me in 2015, "In this entire area the Kurds are probably the most pro-American people that you can find. Forever we will be thankful for the U.S. support since the day of toppling Saddam's regime."
If Washington keeps neglecting and mistreating friends, America's credit rating in the region will suffer irreparable harm. Responsible, pro-American populations, like the Iraqi Kurds, deserve American support.


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Citrulline in Severe Sepsis
This study has been completed.
Vanderbilt University
National Institutes of Health (NIH)
Information provided by (Responsible Party):
Todd Rice, Vanderbilt University
ClinicalTrials.gov Identifier:
First received: November 11, 2011
Last updated: June 2, 2017
Last verified: June 2017
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This is a randomized, double-blind, placebo-controlled, phase 2 study to evaluate biochemical, clinical, and safety effects of 2 doses of intravenous L-citrulline compared to placebo in patients with severe sepsis at risk for or with acute lung injury. The hypothesis is that intravenous L-citrulline will decreased the development or progression of acute lung injury in patients with severe sepsis compared to placebo.
|Severe Sepsis Acute Lung Injury
|Drug: High Dose Citrulline Drug: Placebo Drug: Low Dose Citrulline
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Prevention
|Official Title:
|Prospective, Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Intravenous Citrulline to Prevent or Mitigate Acute Lung Injury in Patients With Severe Sepsis
Resource links provided by NLM:
MedlinePlus related topics: Sepsis
Genetic and Rare Diseases Information Center resources: Acute Respiratory Distress Syndrome Respiratory Distress Syndrome, InfantU.S. FDA Resources
Further study details as provided by Todd Rice, Vanderbilt University:
Primary Outcome Measures:
- Vasopressor Dependency Index [ Time Frame: day 4 ]Worst Value of Index measuring blood pressure hourly through study infusion (day 4). Vasopressor index is mean arterial blood pressure divided by catecholamine index (the catecholamine index is a dimensionless variable calculated as (dopamine dose × 1) + (dobutamine dose × 1) + (adrenaline dose × 10) + (noradrenaline × 100) + (phenylephrine dose × 100), where all doses are expressed in ug/kg/min). (Higher is better)
|Study Start Date:
|August 2012
|Study Completion Date:
|March 2016
|Primary Completion Date:
|March 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Low Dose Citrulline
Low Dose Citrulline
Drug: Low Dose Citrulline
Initial intravenous bolus of 10mg/kg (to a maximum of 1500mg) L-citrulline over 10 minutes. Immediately after the initial bolus, a continuous intravenous infusion of L-citrulline at 4.5mg/kg (max 350mg) per hour will be administered through a dedicated intravenous line or port of a multilumen catheter for 4 days.
Placebo Comparator: Placebo
Placebo IV infusion
Drug: Placebo
D5W IV fluids at isovolumetric rate (about 15ml/hr)
Active Comparator: High Dose Citrulline
High Dose Citrulline
Drug: High Dose Citrulline
Initial intravenous bolus of 20mg/kg (to a maximum of 1500mg) L-citrulline over 10 minutes. Immediately after the initial bolus, a continuous intravenous infusion of L-citrulline at 9mg/kg (max 700mg) per hour will be administered through a dedicated intravenous line or port of a multilumen catheter for 4 days
|Ages Eligible for Study:
|13 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Severe Sepsis
Exclusion Criteria:
- No Consent
- Malignant or other irreversible condition
- Moribund and not expected to survive 48 hours
- End Stage Liver Disease
- Enrolled in another IND study
- Pregnant or breast feeding female
- Age<13 years old
- Allergy to citrulline or arginine
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01474863
Please refer to this study by its ClinicalTrials.gov identifier: NCT01474863
|United States, Tennessee
|Vanderbilt University
|Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Vanderbilt University
National Institutes of Health (NIH)
|Principal Investigator:
|Todd Rice, MD
|Vanderbilt University Medical Center
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Todd Rice, Assistant Professor of Medicine, Vanderbilt University
|ClinicalTrials.gov Identifier:
|NCT01474863 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 11, 2011
|Results First Received:
|March 22, 2017
|Last Updated:
|June 2, 2017
Additional relevant MeSH terms:
Lung Injury
Acute Lung Injury
Respiratory Distress Syndrome, Adult
Systemic Inflammatory Response Syndrome
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Thoracic Injuries
Wounds and Injuries
Respiration Disorders
ClinicalTrials.gov processed this record on September 21, 2017

subset: commoncrawl


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Choose to fly with hand baggage only or pick a price that includes a 23kg checked baggage allowance and free seat selection 24 hours before you fly - both options include complimentary on-board drinks and snacks.
Wenn Sie einen British Airways Flug günstiger finden, erstatten wir Ihnen die Preisdifferenz.
Niedrigpreisfinder und niedrige Anzahlungen.
Wenn Sie mit British Airways fliegen, genießen Sie preisgekrönten Service und ein ausgezeichnetes Preis-Leistungs-Verhältnis und müssen keine versteckten Zusatzgebühren fürchten.
Choose to fly with hand baggage only or pick a price that includes a 23kg checked baggage allowance and free seat selection 24 hours before you fly - both options include complimentary on-board drinks and snacks.
The variety of things to do in Brussels will make your holiday unforgettable. Whatever your duration on holiday type, you'll be pleasantly surprised by the fascinating culture, extraordinary gastronomy and world-famous beers.
Get more from your getaway by booking one of our carefully selected experiences – it's easy to tick off Brussels top attractions on a hop-on hop-off tour. Explore further afield on a Bruges express tour from Brussels or at your own pace with our great value car hire, in partnership with Avis. Admire the splendid Art Nouveau architecture and make the most of the city's free parks, museums and landmarks by day. Then enjoy incredible fine dining and embrace the bustling pub scene by night.
Shopping in Brussels needn't be dedicated solely to fashion, alongside the large Woluwe shopping centre you'll find colourful markets and divine chocolate shops. Pick up Ghent's traditional mustard at heritage listed Tierenteyn-Verlent or satisfy every sense with a trip to Gare du Midi Market – try Moroccan crȇpes with cheese, honey and vegetables, washed down with a mint tea.
Situated in the heart of the city, Grand-Place is considered one of the most beautiful medieval squares in Europe with its ornate buildings that date back to the 17th century. Learn about the Art Nouveau movement at the Horta Museum or be captivated by the hidden treasures of the Museum of Natural Sciences.
Head to Bar Choc, a chocoholics heaven that serves over 44 different kinds of hot and cold chocolate drinks. Enjoy authentic bistro cuisine at Au Stekerlapatte. Or embrace the unique gastronomic experience at Gin Fish. In the absence of printed menus, diners congregate around the open kitchen to watch the chef prepare dishes from the days freshest market ingredients.
Start your Belgium beer experience near the Gran-Palace at La Mort Subite – dare you try their homemade concoction 'Sudden Death'? Hotsy Totsy is a great place for live music – where the rear room doubles as a gallery space for local artists. While Café Belga is ideal for variety, with a DJ on Friday nights and jazz on a Sunday.
Discover Brussels, the gourmet city, by night on this fantastic three hour walking tour. Belgians are reputed to dine out more than any other people in the world and on this guided gastronomic tour you'll find out why. Stop at several restaurants known for their fabulous dishes and sample locally produced Geneva gin and wine. Visit Brussels' tastiest restaurants, sample Belgian specialties and learn about the city's history and culinary traditions. A great trip for food and history lovers.
Upon arrival in Bruges you will visit the Lake of Love, Minnewater and the Beguinage, convent. Afterwards, join a walking tour and discover Our Lady's Church, with the Madonna statue by Michelangelo, the Market Square with the Belfry and the Town Hall Square, with the Chapel of the Holy Blood. During the trip to Bruges a recorded commentary will help you discover the history of Flanders, Ghent and Bruges. For weekend tours only, you can choose to include an optional boat tour along the canals.
Discover why Belgium is so famous for its mouth-watering beers on this Brussels beer-tasting tour. No country in the world boasts a brewing tradition as rich and diverse as Belgium's and this tour is the perfect way to visit some of the finest breweries, learn about the country's beer heritage and taste great beers. This beer tasting experience visits some of Brussels' oldest and most popular cafes where you can taste a selection of eight beers and also enjoy some fine Belgian cheese and frites.
See the best of Brussels on an easy and convenient hop-on hop-off sightseeing tour. The perfect do-it-yourself sightseeing tour in Brussels, the hop-on hop-off tour allows you to see Brussels's top attractions at your own pace, aboard a comfortable open-top double-decker bus with pre-recorded multi-lingual commentary. With 21 hop-on hop-off stops conveniently located around the city on two different routes, you can stop at all the major attractions, including the European Parliament, Grand Place and the iconic Atomium.
The miniature model park of Mini Europe allows you to sample the charms specific to each European country. An adventure you'll experience nowhere else. More than 350 sites and monuments have been reconstructed down to the finest details. Absorb the ambiance of some of the most beautiful cities of the old continent. The unmistakable chimes of Big Ben welcome you to the heart of London. While the gondolas and mandolins serenade you with the charms of Venice.


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With a name like Snoop Dogg, I don't know why I was so shocked to learn how many dogs he has in his household! Although he doesn't count any cats in his furry fam, it seems he got word of this feline that got fitted with a gold grill. Seemingly different from the cat dentures I heard about last week, the procedure cannot only replace missing teeth, but cap existing ones. In order to show his love for all those dogs, they'll each be fitted for grills sometime this month. Rumor has it he's getting a discount for being the first celeb to go all out with this process . . . and who knows who'll come next! Now, as much as I love Snoop, it's a little twisted, doncha think? Find out more (scary) deets when you
HAPPY APRIL FOOLS' DAY! Although this cat did get gold teeth, it was to protect the abnormally protruding ones he had at first. But I wasn't joking about the number of dogs in Snoop's fam, see him introduce them in this clip below.


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Topic: Introduction
My name is Andrew Morrow and I was told in August this year that I have cholangiocarcinoma or bile duct cancer (it's much easier to say and spell!) I was taken into hospial as I had really bad stomach pains and I turned jaundice, at this time the Doc's thought I have gall stones. After ultrasounds and MRI scans thay could not find any stones, so as I was still yellow and in pain they decided to do an ercp and put a stint in the bile duct. During the ERCP they took cell samples and they turned out to be cancer. I was they handed over to a Mr Diamond in the Mater hospital in Belfast and he carried out a Whipples procedure. My cancer had spread through the bile duct and into 1 lymph node, Mr Diamond removed 11 nodes so only 1 was infected. Thankfully the tumor was at the very bottom of the bile duct and my liver is clean. I had the op on the 2nd October and I have recovered very well. I spend less than 2 weeks in hospital. I then was sent to the Cancer centre in Belfast City Hospital were I was told the tumor was completly removed and the docters have every confidence that I will be fine. Its all down to time now to make sure it does not come back, I had very clear margins so God willing I will make a full recovery. I have been offered Chemo to mop up any lose cells and this is due to Start in the 4th December 2006, they are giving me 5FU.
I don't know too much about this illness except that its very rare, and information that I have read says that recovery is rare but I have every confidence that this cancer will not 'get' me as God has been with me every step of the way, infact because of my cancer I turned to God and committed my life to him, he has carried me every step of they way.
God Bless


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Castro unsure about ban on home-plate collisions
KISSIMMEE, Fla. -- Astros catcher Jason Castro isn't so sure he's ready for baseball to ban home-plate collisions -- a belief made public this week by Cardinals manager Mike Matheny.
"It's part of the game," said Castro, who can see both sides of the argument. "I've been hit a few times. It's a dangerous part of the sport. I think, either way, there needs to be kind of a decision one way or the other. … There would have to be a complete ban or leave it the way it is.
"If they try to change the rules and in the heat of the moment trying to remember what's allowed, what's not allowed, those kinds of things, that's what really can get guys hurt when there's in-between thinking."
Castro was bowled over in a nasty collision at the plate last year with Milwaukee's Mat Gamel, who lowered his shoulder and plowed into Castro. He held onto the ball and stayed in the game.
"It's not something you ever really think about until it happens," Castro said. "It's over so fast. Even when I got hit last year in Milwaukee, the rest of the game I wasn't thinking about it after that. There have been guys who have suffered bad injuries, and I can see why people would be pushing for a rule change, because you don't want to see guys hurt. I definitely understand that side of the argument."


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Study on Tolerability of Levodopa/Carbidopa in Children With Angelman Syndrome
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
This study is designed to determine the highest dose of levodopa/carbidopa that can be tolerated without any serious side effects by children with Angelman syndrome.
It has been hypothesized that levodopa may lead to an improvement in the neurodevelopment and abnormal movements (e.g. tremors) in children with Angelman syndrome.
Data from this study will be used to design a phase II trial to determine the efficacy of levodopa in treating children with Angelman syndrome.
|Angelman Syndrome
|Drug: Levodopa/Carbidopa (4:1)
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Dose-escalation Tolerability Study of Levodopa/Carbidopa in Angelman Syndrome
- Maximum Dose of Levodopa/Carbidopa That Can be Tolerated (Without Any Dose Limiting Toxicity) by at Least 3 Subjects. [ Time Frame: 1 week ]
|Study Start Date:
|January 2009
|Study Completion Date:
|June 2010
|Primary Completion Date:
|June 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Levodopa/Carbidopa
Other Names:
Sinemet L-dopa
Dosages are based on levodopa.
Each cohort of 3 subjects will be placed on an increasing dose of levodopa (2, 5, 10, and 15 mg/kg/day) for 1 week, provided subjects in the preceding cohort tolerated the lower dose.
Levodopa/Carbidopa is a combined formulation that will be dispensed as capsules. It should be taken 3 times a day.
Drug: Levodopa/Carbidopa (4:1)
Dosages are based on levodopa.
Each cohort of 3 subjects will be placed on an increasing dose of levodopa (2, 5, 10, and 15 mg/kg/day) for 1 week, provided subjects in the preceding cohort tolerated the lower dose.
Levodopa/Carbidopa is a combined formulation that will be dispensed as capsules. It should be taken 3 times a day.
Other Names:
Detailed Description:
Levodopa is a prodrug that "delivers" dopamine to the brain. It is usually given with carbidopa, a peripheral decarboxylase inhibitor, to increase the bioavailability of levodopa. Animal studies have suggested that levodopa can reverse the excess phosphorylation of some enzymes involved in synaptic and neuronal function, including calcium/calmodulin-dependent kinase type 2 (CaMKII).
Recently, it was shown that excess phosphorylation of CaMKII may be responsible for some of the neurological deficits seen in Angelman syndrome. Therefore, it is hypothesized that levodopa may lead to an improvement in the neurodevelopment and abnormal movements (e.g. tremors) in children with Angelman syndrome.
Although many children have used levodopa for a variety of medical conditions over the last 30 years, it has not been approved by the Food and Drug Administration (FDA) for use in children, and it has not been formally studied in children with Angelman syndrome, so we do not know what dose of levodopa is most appropriate for children with Angelman syndrome.
Therefore, the purpose of this study is to find out the highest dose of levodopa that children with Angelman syndrome can tolerate without any serious side effects.
Once we know the dose of levodopa that can be tolerated by children with Angelman syndrome, we will conduct a larger follow-up study to find out whether levodopa will lead to an improvement in their development and tremor.
|Ages Eligible for Study:
|4 Years to 12 Years (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Angelman syndrome, confirmed by molecular testing
- Must be willing to come for research visit on 2 days, exactly 1 week apart
Exclusion Criteria:
- On levodopa, carbidopa, or any dopamine agonists in the 2 weeks prior to participation
- Other medical conditions that may be associated with developmental or cognitive delays
- More than 2 clinical seizures per month
- Used monoamine oxidase (MAO) inhibitors within the last 2 weeks
- Used phenytoin within the last 2 weeks
- Used phenothiazines, butyrophenones, and thioxanthenes within last 2 weeks
- Hypersensitive to levodopa or carbidopa
- Cardiovascular disease or instability
- Respiratory diseases, including asthma, emphysema, chronic cough, and shortness of breath
- Liver disease
- Stomach or intestinal ulcers
- Kidney disease
- Hematological problems, including anemia, leucopenia, and thrombocytopenia
- Used investigational drugs/interventions within the past three months
Please refer to this study by its ClinicalTrials.gov identifier: NCT00829439
|United States, Massachusetts
|Children's Hospital Boston
|Boston, Massachusetts, United States, 02115
|Principal Investigator:
|Wen-Hann Tan, BMBS
|Boston Children's Hospital
|Responsible Party:
|Wen-Hann Tan, Attending Physician in Genetics, Boston Children's Hospital
|ClinicalTrials.gov Identifier:
|NCT00829439 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 26, 2009
|Results First Received:
|August 5, 2016
|Last Updated:
|September 29, 2016
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Keywords provided by Wen-Hann Tan, Boston Children's Hospital:
Angelman syndrome
Additional relevant MeSH terms:
Angelman Syndrome
Pathologic Processes
Movement Disorders
Central Nervous System Diseases
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Carbidopa, levodopa drug combination
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Aromatic Amino Acid Decarboxylase Inhibitors
Enzyme Inhibitors
Adjuvants, Immunologic
Immunologic Factors
Dopamine Agonists
ClinicalTrials.gov processed this record on September 21, 2017


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AN ANNUAL award which has promoted the teaching of traditional trades and skills in Cornwall and the Isles of Scilly has been revamped for 2013.
The Duke of Cornwall's Award will now be for farm business diversification and will be presented at the Royal Cornwall Show in June.
The award will be made to the farm business that is adjudged to have most successfully diversified its enterprise and the organisers are now seeking nominations.
There have been seven recipients of the award in its previous form - from a thatcher to a shipwright and from Cornish hedging to baking. Now farmers running businesses from the land or buildings on their farm are in the spotlight.
Young people and their employment are still very much part of the award, but it was felt that the criteria should be widened to reflect the need for innovation and diversification in the rural economy.
The judging panel will be looking at a wide variety of issues, including commercial viability and sustainability, creativity, contribution to the local economy, employment opportunities (in particular for young people) and community benefit.
B&B and holiday cottage enterprises are not eligible for this award.
Entries are invited from all sizes of business. An application form is available from firstname.lastname@example.com or by phoning 01208 812183.
Anyone can make a nomination (not for themselves), as long as the nominee is aware of it.
The award carries with it a perpetual trophy (to be held for the year) and a signed certificate plus a cash prize of £1,000 from His Royal Highness the Duke of Cornwall.
Closing date for applications is 1st March, 2013.
Christopher Riddle is secretary of the Royal Cornwall Agricultural Association, which administers the award.
He said: "There is no doubt that the award in its previous form has been widely welcomed by all its recipients and that it has helped to raise widespread awareness of the importance of traditional skills and trades to today's economy.
"This is still recognised in the revamped award, which His Royal Highness feels is now more suitably matched to the needs of those farm-based enterprises which are investing in local people and produce and which are finding markets both close to home and further afield."


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10mm Retro-Mark - Orange (sheet of 400)
Price: £45.00
Product Code: 30210
- An inexpensive range of retro-reflective targets available in four different colours.
- These targets work with most EDMs and are ideal for monitoring work where you have to leave targets in position over long periods.
- A single target will give a measuring range in excess of 100m with mm accuracy and an angle of intersection of up to 60 degrees.
- Greater distances can be achieved by using multiples of 5 and 9 targets which are easily attached with the self-adhesive backing.
- Sheet of 400.


text: Vines & Vittles: Greenbrier's wine list impresses By John Brown September 3, 2011 Story Share CHARLESTON, W.Va. -- If you are a wine and food fanatic (and you wouldn't be reading these words otherwise), you've got to love what Jim Justice has done in breathing new life into The Greenbrier resort. Let's face it, the grand old lady was slipping before he stepped up and rescued this venerable and historic resort.By renovating the rooms and public places, constructing a very tasteful casino and developing a world-class golf tournament, Justice is working tirelessly to upgrade the resort with the goal of achieving five-star status.With all due respect to these achievements, I am particularly impressed with the efforts to elevate the wine program and cuisine at The Greenbrier. In addition to the elegant Main Dining Room, Draper's and Sam Snead's at the Golf Club, the resort has added In-Fusion (a pan-Asian restaurant), The Forum (Italian) and Prime 44 West Steakhouse, named after basketball great and state native Jerry West.I've had the pleasure of dining at all of the establishments mentioned, and I can tell you that particular attention is being paid to making sure that the wine lists are specifically tailored to the menus of the various restaurants.Should that come as a surprise? Well, the range of complex dishes prepared at the various dining venues is stunning, and it would be so much more manageable to keep just one well-rounded list and use it for each different restaurant.But not at The Greenbrier. Through coordination and consultation among food and beverage president Jeremy Critchfield, executive chef Richard Rosendale and director of wine Heath Porter, the resort is able to tailor each restaurant's menu with wines that match and enhance the culinary focus. And since the menus are regularly evolving, the wines are constantly changing.So, if you have not visited the resort recently, you should treat yourself and that special other person in your life to a little R&R at The Greenbrier. In fact, the resort is offering a few wine-oriented events this fall that should tickle your palate:Trefethen Vineyards Janet Trefethen, of the Napa Valley winery of the same name, will be at The Greenbrier on Sept. 9 and 10. Trefethen Vineyards has been winning international acclaim since the 1970s and features some of the most elegant cabernet sauvignon made in Napa. In fact, the winery provides the cabernet for Prime 44, the Jerry West signature label.Trefethen is the matriarch of this family winery and will lead guests in a tasting from 5 to 6 p.m. Sept. 9 ($50 per person). At 6:30 p.m. on Sept. 10, Trefethen will join Jerry West and other guests in a special wine dinner at Prime 44 ($250 per person).Talley VineyardsBrian Talley, of Talley Vineyards, will be at the resort on Oct. 6 and 7 for a tasting and grand wine dinner. Talley Vineyards is located in the Arroyo Grande Valley, just south of San Luis Obispo in the heart of California's Central Coast wine region. The winery focuses on chardonnay and pinot noir.At 4:40 p.m. Oct. 7, Talley will lead a tasting featuring six wines, including many single-vineyard wines and older vintages ($40 per person). At 6:30 p.m. Oct. 7, join Talley and other guests for a special five-course dinner with six matching wines ($150 per person).Qupe VineyardsBob Lindquist, winemaker of Qupe Vineyards in California's Santa Maria Valley (just north of Santa Barbara), will showcase his wines at 5 p.m. Oct. 28 at 5 p.m. ($50). Lindquist and Qupe focus on Rhone Valley varietals such as marsanne, viognier, grenache and syrah. Qupe is considered among the finest syrah producers in the U.S. The tastings and dinners are open to the public. Reservations are required and may be made by calling 800-543-4858. Story Share Story Share Trending Now 1 Plans for all-ages venue rise in old bakery building 2 City of Milton tries to revive Morris Memorial property 3 Longtime WV SUPCO clerk leaving for federal court 4 Man arrested after explosion in Kanawha City dumpster 5 Mitch Vingle: WVU's Lyons watching bombshell merger news Healthy Bites: Well-balanced squash relish is addictive Previous Story 'Project Runway' finalist to host Town Center style-off Next Story


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I tried to submit a review and got really strange error, is there something wrong with the review system?
Here is my review of the Spider Monkey bag:
My Review:
I first heard about Gorilla Boy bags here on DGR and it soon became clear that these were the bags for me. Since I can't find a reason to carry more than a dozen discs, the Spider Monkey was the one I chose.
It can hold ~10-12 discs in the main compartment, two putters in the putter pocket (tight fit and ,if need be, you can use the back pocket for another disc. So this little bag holds upto ~15 discs.
The main compartment has a PVC frame that acts as both a "disc keeper" and a stabilizer so your bag doesn't flop over when you set it down. This is really nice touch not seen in many small bags these days.
The bag has a mesh pocket on one end, large enough for a folded up poncho. On the other end is a zipper pocket thats great for holding your cell phone, keys or some about the size about 4 inches by 8 inches in size. There is a putter pocket on the front side and is big enough to hold two of most putters. Atteched to the front of the putter pocket is a mini pocket with the Gorilla Boy logo on it.
There are hook-ups on the bag for should straps and a clasp for an umbrella or towel or even to hang a second watter bottle.
The tip lid of the bag is half zippered and have velcro. The top zips up to seal the main compartment and flap extends from where the zipper end down to cover the putter and mini pockets. The flap is great for wet weather play as it keep water off your discs and putters.
The Spider Monkey seems be a bit lighter than even the Revo mini bag, so it saves on your shoulder. The bag also looks great, in my opinion the nicest looking bag there is. It comes in several colors though I had mine mad in camo.
All Gorilla Boy bags are handmade and darn near bullet proof: Sturdy. The seams are all double stitched for extra strength and all the clasps and hardware are plenty strong.
A golf bag may not directly improve your game, but the Spider Monkey has made it easier for me to carry my discs in comfort. By carrying a lighter more well constructed bag, I feel like I have improved my game.


text: these are great aviators from Tom Ford. The only reason I would give a 4 is the cost, but these were gifted to me so I didn't have any gripes with them. They aren't too dark so that it hinders your vision (my mom steals them because she hates black lenses). Overall great aviators


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StartUpHire is the place to find Mobile jobs in and near palo alto. Review the list of Mobile palo alto career opportunities to the left. These Mobile jobs represent some of the most rewarding careers available.
You can refine your job search for Mobile career opportunities in palo alto by adding a job title, company name, or keyword to the search box above … or click the "Advanced Search" link for more options.
Don't see the employment opportunity you're looking for? Check back soon for more Mobile jobs in palo alto, or sign up for an email alert (link below) to receive periodic updates on new Mobile jobs in palo alto, CA.
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text:
Fewer Dollars Spent Bad News for Nabors Industries, Superior Energy
Cowen was feeling pretty good about the oil services sector until it surveyed exploration & production firms and found that its original spending estimates were off. Way off. Like a Blaine Gabbert pass.
As a result, the knives have come out. Cowen's analysts downgraded six stocks--Baker Hughes (BHI), Cameron International (CAM), Nabors Industries (NBR), CGG (CGG), Superior Energy Services (SPN) and Helmerich & Payne (HP)--and cut their estimates on even more. Its analysts explain why:
Our Original E&P Spending Survey published today estimated just 4% growth globally in E&P spend in 2014. Given our estimates were based upon an 8% gain in 2014 and a similar increase in 2015, we are lowering our estimates for many of the stocks we cover.
As the market digests a slower growth outlook for 2014, we think consensus earnings estimates will come down. It will be difficult for the oil service and drilling stocks to perform well given this scenario. Thus, we are lowering our opinion on six of the stocks we cover.
Our investment opinion on six stocks is being reduced to Market Perform from Outperform given our reduced industry growth estimates for 2014 and 2015, our lower earnings estimates and valuation.
And wouldn't you know it--five of the six stocks have fallen today. Superior Energy has dropped 2% to $25 at 2:31 p.m., while Nabors Industries has dropped 2% to $16,62, Baker Hughes has decline 1.5% to $52.58, CGG is off 0.8% at $16.49 and Cameron International has ticked down 0.1% to $58.51. Helmerich & Payne has gained 1.6% to $83.27.


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Testing Tools at a Conference Week in Zurich
July 21, 2011 | Posted by Microsoft Research Blog
The beautiful interior of the Eidgenössische Technische Hochschule's (ETH, the Swiss Federal Institute of Technology) main building in Zurich is always abuzz with conferences at the end of June, including TOOLS—and this year was no exception. Now in its forty-ninth iteration, TOOLS was a week-long event that brought together four major conferences, eight workshops, and a tutorial on the subject of programming languages, models, components, and proofs.
ETH is a world-famous institute for science and technology; it has produced 21 Nobel Prize winners since its inception in 1855—with seven since 1975—a top score among European universities. Perhaps ETH is more widely known as the place where Albert Einstein began his studies. The chair of Software Engineering is held by Bertrand Meyer, who started the TOOLS Conference Series in 1989 with conferences held in different continents: TOOLS Europe, TOOLS USA, TOOLS Pacific, and TOOLS China. Eight people from Microsoft were right at the center of the event this year.
With program committees spread across the world, holding a program committee meeting to discuss the selection of the papers for the conference is a challenge—but one that TOOLS has always met. This year, I had the honor of serving as program co-chair of one of the conferences, and Ethan Jackson was program co-chair of another. The collected papers from TOOLS are available as a volume entitled Objects, Components, Models, Patterns in the prestigious Lecture Notes in Computer Science series, published by Springer.
The program committee meeting for 2011 was held in Zurich in March with 16 members present and 16 listening in from various regions ranging from India to the United States' west coast. With very careful planning, papers were scheduled for discussion according to the time zone in their reviewers' regions. Thus, Aditya Nori from Microsoft Research India was brought in first, and Nikolai Tillmann from Microsoft Research Redmond, Washington, had to rise very early to discuss his papers at the end of the meeting.
Other Microsoft researchers who participated in the conference week included Yuri Gurevich, the conference co-chair of TAP (Tests and Proofs), and program committee members of the various conferences: Nikolaj Bjorner, Clemens Syzperski, Margus Veanes, and Madhu Sudan. (I should note that Nikolaj Bjorner and his team are well known for having popularized the use of testers through RiSE4fun, which enables the tools to be run in browsers.)
Patrice Godefroid presented the keynote address for one of the conferences: TAP 2011. He discussed his work with the SAGE tool for white-box testing technology. Test generation has recently become the largest application of SMT solvers as measured by computational usage. Satisfiability Modulo Theories (SMT) are concerned with checking the satisfiability of logical formulas over one or more theories. At Microsoft, the Z3 SMT solver has solved more than 2 billion constraints in the past two years as a sub-component of SAGE, the first white-box fuzzer. Fuzz testing is an effective technique for finding security vulnerabilities in software. Traditionally, fuzz-testing tools apply random mutations to well-formed inputs of a program and test the resulting values.
Patrice Godefroid – Automated Whitebox Fuzz Testing with SAGE
Since 2009, SAGE has been running non-stop on more than 100 (on average) machines, automatically "fuzzing" hundreds of applications in a dedicated lab that is owned by the Windows security test team. In the process, SAGE found many new expensive security vulnerabilities (which were missed by black box testing and static program analysis).
—Judith Bishop, Director of Computer Science, Microsoft Research Connections
Learn More


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Best Smartphones for Christmas
Stay connected to loved ones with a new smartphone this Christmas. Check out our list of the best smartphones for Christmas to help you find the perfect gift.
This case is perfect especially for so cheap. If there was one problem I had with it it would be the fact that the actual screen needs more protection....
ITEM#: 14736991This is an Insten black hard/ purple skin hybrid case for Apple and iPhone 4/ 4S. Protect your cell phone against bumps and scratches with this accessory set.
|Supported Device
|iPhone 4, iPhone 4S
|Model Number
|Country of Origin
The color is cute, like the photo. However, when I received it, it had a huge rip at the top. You can tell that whomever packaged it definitely knew the rip was there.Read More
It was a decent product for the priceRead More
This case is perfect especially for so cheap. If there was one problem I had with it it would be the fact that the actual screen needs more protection.Read More
If you want the great quality you will have to spend the money on an Otterbox case.Read More
I received the product and right away noticed how cheaply made it was. Part of it was torn and was not the best made product made. I will never buy again. I hope that all the products sold on this site are not like this, but i do know I will not buy again here.Read More
The description is misleading.....it says it's a hard case but it's a flimsy, rubber case. I do like the color, but the quality stinks.Read More
Stay connected to loved ones with a new smartphone this Christmas. Check out our list of the best smartphones for Christmas to help you find the perfect gift.
From rugged and waterproof outdoor speakers to wireless speaker sets for quality indoor surround sound, Bluetooth speakers are a must-have for the music lovers, partygoers, and outdoor enthusiasts on your list. Check out these top trends to get started on your Christmas 2016 shopping.
In the hurry and flurry of Christmas Day, don't overlook the gifts found in Christmas stockings. Stocking stuffers are usually smaller and less expensive than what you put under the tree, but they're a thoughtful and ideal way to celebrate the personality or interests of those on your list. Peruse our options and you'll be ready to grant the holiday wishes of the special people in your life.
Forget the flowers and chocolate, and treat the man in your life to an extra special gift this Valentine's Day. Finding the perfect gift is sometimes difficult, but remember that you can't go wrong with a thoughtful, personal, and romantic present during this holiday devoted to all things love. If you're looking to give your significant other a truly memorable Valentine's Day gift, here are a few suggestions.
Extended Warranty Buying Guide from Overstock.com. Our guides provide customers with information about extended warranties.
Our standard shipping method is ground shipping. We also offer expedited shipping for most items. Your final
shipping cost and estimated delivery timeframe will be available at checkout.
Standard shipping details
Expedited shipping details
The items must arrive at our warehouse within 30 days of purchase. You must return items in their original condition to qualify for a full refund. We will issue a partial refund of up to 70 percent if returned items have been opened, used, or returned late. More Details
For your protection, all orders are screened for security purposes. If your order is selected for review, our Loss Prevention Team may contact you by phone or email. There may be a two business day delay to process your order.
** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.
INSTEN Black Hard Plastic/ Purple Skin Hybrid Phone Case Cover for Apple iPhone 4/ 4S
Today $4.49


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At the end of a shaded trail, will you choose the sauna or the hot spring?
Linger in the pure, steam-fired broth of this first-flush green tea thinking clear, peaceful thoughts. Like watching mist rise off a thermal spring, hidden behind a wooded glen and only accessible by trampoline.
Green Tea
The liquor of a green tea is typically a green or yellow colour, and flavours range from toasty, grassy (pan-fired teas) to fresh and streamed greens (steamed teas) with mild astringency.
Did You Know?
Tazo® China Green Tips is made from a tea known as Mao Feng, which in Chinese translates loosely as "hair tip" — an apt description of the twisted and rolled dry leaf.
For Best Brewing
- Bring fresh, filtered water to a boil at 175F (80c) and allow to cool slightly.
- Pour 8 fl oz (236 ml) of water over the filterbag in your cup.
- Let it steep for 3 minutes. Wait patiently for perfection.
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Topic: FEVERS and CHILLS
My brother n law has 2 cycles of chemo gencytoben and oxyplation. We worry about his consistent fevers. He had a 7 day course of antibiotics and still has fevers, bed sweating and chills. We worry about his metal stents but he shows no signs of blockage. Any suggestion? Are fevers typical????


text:
Reviews, reviews, reviews...
FreakScore is a weighted average of all aggregated professional and user review scores.
Read more
This product has a FreakScore of 4.2
out of 10 based on 456 scores.
Canon's PowerShot A560 is a follow up of the model A550; both
Read more
Best Price at Amazon


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Rays owner Sternberg won't rush any moves
While many think club will be sellers, that could change
NEW YORK -- Rays principal owner Stu Sternberg attended Tuesday night's Rays-Yankees game at Yankee Stadium. And his message was clear: He hasn't given up on the season.
That sentiment is significant given the fact the July 31 non-waiver Trade Deadline is looming and Rays left-hander David Price is the most coveted name rumored to be on the trade block.
However, the Rays are playing better lately, giving the impression that their 2014 season still has a pulse. At the very least, Sternberg made it sound like waiting until July 31 to make any drastic moves would be the prudent move.
"My M.O., and this, if nothing else, filters down through the organization, and everybody knows it about us just by our actions, I'll wait as long as I need to make a decision," Sternberg said. "If it will give us a clearer picture on what's ahead of us."
Sternberg brought up the 2011 season, when speculation suggested the Rays would be sellers at the Trade Deadline and they were not.
"People had a full expectation for the month of July that we were going to do some relatively dramatic things at the end of the month with some players, both for money purposes and what not, and none of that happened," Sternberg said. "We made some decisions then.
"A lot will depend on how the team is playing, what's happening around us. What other teams are looking to do to improve or even something we can do to improve. We could go the other way in a couple of weeks and say, 'What are we missing?'"
While Sternberg didn't sound like a seller on Tuesday, he did not sound at a loss for understanding the importance of any decision the Rays make at this point.
"Part of the opportunity we have for success is David's performance," Sternberg said. "He's been doing a great job and getting things done. I think most importantly we all look back to the semi-miracle of what happened in 2011, and time can be made up. But you have to have confidence in your team.
"And I think the players are clearly focused on one game at a time. We really are taking it a day and a week at a time to see where we stand. Obviously we'd have some decisions to make at some point in time, potentially. Make decisions not to do something, make decisions to do something. I want to emphasize when you don't do something, that's a decision in itself. So we're always evaluating and making decisions."
Bill Chastain is a reporter for MLB.com. Jake Kring-Schreifels is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Hazelwood coalmine fires could have been ignited by falling embers from nearby fires: hearing
A ''camp fire'' near Morwell has been blamed for causing a bushfire which authorities suspect could have spotted into the Hazelwood open cut coalmine, contributing to a fire which burnt for 45 days, shrouding the town of 14,000 in smoke and coal ash.
The inquiry was told that a fire investigator concluded that a camp fire ignited the Hernes Oak fire on February 7, two days before the coalmine fire ignited. The fire, to the west of Morwell, was deemed a major threat to lives and property on the town's western side and is the second blamed on human activity linked to the mine fire.
The other nearby fire, which police believe was lit by an arsonist alongside the Strzelecki Highway at Driffield on Sunday, February 9, has also been blamed for sending falling embers into the coalmine.
On a dramatic first day of the Hazelwood Mine Fire Inquiry, Fire Services Commissioner Craig Lapsley told the hearing that it was possible that both fires spotted into the coalmine, based on the large convection columns each fire caused and how they behaved.
While the inquiry was told that a fire investigator found that a ''camp fire'' ignited the Hernes Oak fire, Mr Lapsley added that the fire could also be considered ''suspicious''.
Mr Lapsley, the first witness, also confirmed parts of the mine did not have extensive sprinklers or water pipes to tackle fire. Asked what impact a comprehensive network of pipes and pumps would have had in combating fire, he said: ''A more sophisticated network means you get water onto coal in a quicker way, which would suggest that you've got a better chance of suppression.''
In other developments the inquiry was told:
■ There are about 100 small fires in the Hazelwood coalmine each year, usually in the working part of the mine.
■ Extra aircraft requested for the Latrobe Valley by first light on the fire's first day (February 9) did not come until mid-to-late morning.
■ There was about an eight-hour gap between the first reports of a coalmine fire and the CFA formally assuming control of the fire effort.
■ 950 fires were reported across Victoria in a 24-hour period spanning February 8 and 9.
Mr Lapsley said he sent the chiefs of the CFA and MFB to inspect the coalmine fire on Monday February 10 and considered it the most significant fire burning in the state at the time.
He also strongly defended the level of aircraft resources sent to Gippsland in a period described as the worst conditions since Black Saturday, saying 14 firefighting aircraft out of 54 were in Gippsland. ''Do your percentages about where we've got it, there's a reasonable cut of the fleet in Gippsland.''
Counsel assisting the inquiry Melinda Richards told the hearing there had been ''several significant fires at the Hazelwood mine since it was privatised'', including in 2005, 2006, 2008 and 2012. The fires during the past decade ''were all ignited from sources inside the mine'', she said.
And she said the Latrobe Valley was ''located in a notoriously bushfire-prone region. There are fires in the area every summer, sometimes catastrophic. Five years ago, on Black Saturday in 2009, the Churchill fire claimed 11 lives, injured 35 others and destroyed 145 houses,'' she said.
Staff of mine owner and operator GDF SUEZ will appear as witnesses at the inquiry on Tuesday.
Darren is a rural affairs reporter for The Age.
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PICUM » News » PICUM News » Access to Justice: A Reality for Undocumented…
Access to Justice: A Reality for Undocumented Women in the EU? Lunchtime event in the EP
Launch of PICUM's seminal report "Violence Against Undocumented Women in Europe - Protecting Rights and Ensuring Justice" at a lunchtime event in the European Parliament on Thursday, 21st June, 12:30 - 14:00 .
A Reality for Undocumented Women in the EU?
THURSDAY, 21st JUNE, 12:30 - 14:00
PHS 01C051 (behind Menuhin space)
This roundtable, hosted by the Chair of the Committee on Women's Rights and Gender Equality (FEMM), Mr Mikael Gustafsson (MEP), will highlight the lack of access to justice and services for undocumented women experiencing violence in the EU. Because of their immigration status, they are turned away from women's shelters and risk arrest or deportation if they contact police. By not addressing this situation, Europe is fostering a culture of impunity for violence against women and endangering its founding values of equality and non-discrimination.
PICUM's report offers the first exploration of women whose status prevents them accessing support, shelter and justice in the EU. It presents a comprehensive overview of the legislative, financial, and practical measures that exist in various member states to ensure equal access to justice and services. To highlight the realities on the ground, PICUM will screen an excerpt from its forthcoming webdocumentary.
We sincerely hope that you join us to show your support for their right to a life free from violence, discrimination and impunity.
A sandwich lunch and refreshments will be served and we will be disseminating hard copies of the report (in English, French & Spanish)
Click here to see the poster of the event.


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While someone gets it online, the Cliff Notes version of Pelton's article: per the numbers so far this year... yes, they are the best defense of all time.
When it comes to defense, the Indiana Pacers have been outliers this season. Plotting the NBA's defensive ratings so far requires stretching the axis to include the Pacers, who have allowed just 93.5 points per 100 possessions in a league in which the average team allows 105.9.
Only one other team, the San Antonio Spurs (98.8), allows opponents less than a point per possession, and the difference between Indiana and the third-place Chicago Bulls (100.9) is larger than the gap between the Bulls and the team ranked 23rd (New Orleans Pelicans, 108.1).
As early as it is, such dominance requires us to consider whether the 16-1 Pacers might have the best defense in NBA history -- and how they've gotten here.
Better than the best
Of course, Indiana already was the league's best defensive team last season, allowing 100.7 points per 100 possessions. And the Pacers' prowess was on full display in the playoffs, as they shut down the league's No. 3 offense (the New York Knicks) and held the No. 1 offense (the Miami Heat) in check during the Eastern Conference finals. As the Memphis Grizzlies can attest, however, elite defense doesn't necessarily carry over season to season. But somehow, the Pacers have gotten better.
It all starts in the middle, where Roy Hibbert has built on last season's impressive postseason run to emerge as the league's premier individual defender. Hibbert has improved his block rate from 6.7 percent of opponents' 2-point attempts last season to 9.2 percent this season, while simultaneously cutting his foul rate, a development that began in the 2013 playoffs as referees began giving Hibbert the benefit of the doubt when he contested shots while remaining vertical. The result has been the league's second-best rate of blocks per foul (1.2), trailing the Spurs' Tim Duncan (1.33).
In addition to putting opponents on the free throw line less frequently because of Hibbert's ability to defend without fouling, Indiana is forcing more turnovers. The Pacers, who ranked just 26th in the league in opponent turnover percentage last season, have jumped into the league's top 10 in 2013-14. According to NBAWowy.com, the Pacers have drawn a league-high 52 offensive fouls through Friday.
Indiana has improved elsewhere without sacrificing its ability to defend shots. Opponents have barely made 40 percent of their 2-point attempts against the Pacers, far and away the league's lowest mark. Remarkably, just 11 players in the league with at least 100 2-point attempts have shot as poorly this season as the average Indiana opponent.
Tested by the West
Skeptics will note that the Pacers have benefited from a weak November schedule. Of the NBA's top 12 offenses on a per-possession basis, 11 reside in the Western Conference. Indiana has faced just three of them. The average Pacers opponent ranks 23rd in the NBA in offensive rating.
Accounting for that easy slate takes a little air out of Indiana's impressive start. The Pacers have allowed 12.1 percent fewer points per 100 possessions than league average but are holding their opponents just 9.0 percent below their typical performance. Nonetheless, that mark will still be the best in post-merger NBA history if Indiana can maintain it all season:
The schedule will soon even out. Indiana's win over the Los Angeles Clippers on Sunday was the start of a five-game trip that features matchups against four of the West's top five teams. That includes a visit Monday night to the fast-starting 14-3 Portland Trail Blazers. Then, after the Pacers return home, the two-time defending champion Miami Heat pay a visit a week from Tuesday. At the conclusion of this stretch, we'll have a lot better idea of whether Indiana's defense is historically great -- and whether the Pacers can hang on to the top spot in the East all season.
The sincerest form of flattery
It's impossible to separate Indiana's success defensively from its personnel. Hibbert is the early favorite for Defensive Player of the Year, and budding superstar Paul George might join him on the All-Defensive First Team. George Hill and Lance Stephenson also are effective on the perimeter, and David West's versatility enables him to match up with both traditional big men and stretch 4s.
But coach Frank Vogel has found a scheme that takes full advantage of their skills -- in particular Hibbert's ability to contest shots in the paint -- so the Pacers are able to minimize high-efficiency looks inside and beyond the arc. While conceding that the defense wouldn't be as effective without Hibbert, Vogel recently told reporters he would consider a similar philosophy with different personnel.
"I think this is how you have to build a defense with players like this," he said. "If you don't have size, there's other things you could do that might make more sense."
Vogel's peers might be starting to come to the same conclusion. Elements of Indiana's defensive scheme have begun to trickle throughout the league -- most notably in Portland. The Pacers will recognize how Blazers coach Terry Stotts is having his big men sink to the paint against pick-and-rolls while perimeter defenders stay at home on shooters.
Portland, which ranked 26th defensively last season, hasn't seen anywhere near the same results. Still, the new scheme -- anchored by 7-footer Robin Lopez, acquired in a summer trade -- has helped the Blazers improve from 26th to 10th in opponents' effective field goal percentage. Portland actually has outdone Indiana by allowing opponents to attempt 3-pointers on barely 20 percent of their shot attempts, the league's second-lowest mark. (The Pacers rank third, with the Boston Celtics No. 1.)
In a league that emphasizes efficient shot selection on offense, smart coaches are trying to take those high-value attempts (corner 3-pointers and shots around the rim) away from opponents. And nobody has done a better job of that -- now and maybe ever -- than this season's Indiana Pacers.
"Remarkably, just 11 players in the league with at least 100 2-point attempts have shot as poorly this season as the average Indiana opponent."
Best Pacers defense ever? yes. and considering 1994 and 2004 that is saying a lot.
Best NBA defense ever? Way, way too soon to make such a claim.
best NBA defense I have ever seen was the 2004 Pistons after they acquired Sheed
When you couple it with what we saw from game 20 or so last year on, and then the first 17 games this year, I don't think it's too early to say it's in the conversation
Per Pelton's article, the 2004 Pistons team was actually the 6th best all time. This is using a metric of how much below a team's typical performance (as a percentage) does an opponent defense hold them to. He actually shows how San Antonio had a better defense that same year with those criteria.This quote is hidden because you are ignoring this member. Show Quote
It is very hard to maintain defense of this level from year to year, even SAS has had years where they rely more on offense to get done. Memphis was having a huge drop off defensively even before Marc Gasol got hurt. A big point of pride for this should have to go to Frank. Coaches are so important to defense, obviously you have to have the personnel to play a certain way, but Frank has maximized this team's talent from day 1.
So true, as long as you have players willing to play defense you can play good defense, even if you aren't especially long or athletic. The most important person in convincing a player to want to play defense is the coach.This quote is hidden because you are ignoring this member. Show Quote
That is why I hope Lionel Hollins is picked up by a West Coast team. He emphasizes defense, and some how got the Grizzlies to the WCF without much three pointers. The Pistons offered him an assistant job but he turned them down. They should have offered him the head coaching job.
Thanks ESPN Insider! RUDE!
Clearly not now that we're playing teams that don't suck.


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European Convention on spectator violence
Standing Committee
Joint Project "Promoting Safety, Security and service at sport events" (PRO S4)
Safety, security
and service
Convention on Safety, Security and Service
Working structures
Reports on national policies and list of national legislations
Convention on the Manipulation of sports competitions
Joint Project "Keep Crime out of Sport" (KCOOS)
European Convention on spectator violence
Spectator violence
General (see EPAS)
|Restricted access
T-DO and T-RV
Conclusions of the Monitoring Group of the Anti-Doping Convention (T-DO)
Extraordinary meeting of the Monitoring Group
Strasbourg, 5 November 1998
The Meeting was called:
to discuss the events of the summer and autumn and their implications for the work of the Monitoring Group;
to prepare the Monitoring Group's contribution to the World Conference on Doping convened by the International Olympic Committee in February 1999.
The fight against doping in sport has entered a new phase, and faces serious new challenges. All Parties and partners in sport need to find new ways of working - in their own sphere and together - and to establish more effective programmes to counter this scourge.
Part I
The Parties to the Convention agreed a number of priority issues for action by the Monitoring Group or at national level:
1. With regard to law:
to undertake a review of national laws affecting anti-doping work (anti-doping laws, laws on medical or banned substances, etc) with a view to examining the scope for possible improvements and for greater consistency in the framework of the Anti-doping Convention;
to help provide information for national sports bodies on how the rule of law – including the Anti-doping Convention – affects sport.
2. With regard to medical care of sportsmen and sportswomen:
to improve the medical care and health protection of sportspeople, and to provide better information and education for those working - medically and otherwise - in their entourage, for example, through codes of professional conduct. National Medical Associations should be invited to draw up clear rules (with sanctions) on this matter. In this context, the Monitoring Group welcomes the co-operation of the IOC in the production of a CD-Rom and Internet versions of the Clean Sports Guide.
3. With regard to the availability of banned substances:
to seek, through the appropriate channels at national level, closer co-operation with police, customs and other relevant authorities with a view to reducing the supply of doping agents to sport and their use/demand within it. Research into the sociological aspects of the doping phenomenon could also help such reduction.
* * * * *
The Monitoring Group also stresses the need for national anti-doping agencies to increase the number of, and to reduce to a minimum the notice given for, out-of-competition controls. Another priority is to seek methods better to detect and to control the use of doping substances, EPO and other peptide hormones in particular. Regulations to prevent over production of these substances should also be introduced.
Part II
The Extraordinary Meeting also agreed to five proposals that would form the basis for the Monitoring Group's delegations' submissions to the IOC Conference with the aim of boosting the effectiveness of anti-doping work in general and of improving co-operation and harmonisation between the sports movement and that of the public authorities active in this field. Participation by the Monitoring Group in anti-doping during major international competitions could also help ensure consistency and transparency.
1. With regard to the proposed Olympic anti-doping agency
The Monitoring Group supports the creation of such an agency, which should help to integrate the strategies and the activities already carried out by international sports federations and agencies. It could play an important role in inaugurating world-wide out-of-competition testing, especially in regions and countries without effective anti-doping programmes at the moment. Its activities would also need to complement those of existing national anti-doping agencies which presently carry out approximately 85% of anti-doping work. The agency should be authoritative, independent, international, transparent and non-profit making. It should have a research component. The Monitoring Group, which consistently seeks a better harmonisation and co-ordination of anti-doping work at international and national levels, would wish to play an active part in it, and will make proposals for its work in due course.
2. With regard to medical supervision
The Monitoring Group will encourage the IOC, the IFs and NOCs to supervise more closely the entourage (medical and other) of athletes and teams.
3. With regard to eligibility and sanctions
The Monitoring Group will ask the IOC to ensure that only those international federations adopting and effectively applying the common Medical Code proposed by the IOC, (including in particular the application of recommended sanctions in case of infractions, and the protection of the rights of sportsmen and sportswomen), can participate in the programmes of the Olympic Games.
4. With regard to the list of prohibited classes of substances and prohibited methods
The Monitoring Group – which, as a contribution to harmonisation, adopts the same list of prohibited classes of substances and prohibited methods as the IOC's list - will ask the IOC to make concrete proposals on ways in which it can be associated with the drawing up this list.
5. With regard to the anti-doping laboratories
In accordance with Article 11.1.b of the Convention, and as most accredited laboratories are financed by public funds in the country concerned, the Monitoring Group would like to be associated with the IOC in establishing quality systems and standards for anti-doping laboratories.


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A decade ago, a home with a $100 million price tag seemed unbelievable. Now there's a luxury property on the market with a listing price of nearly twice that.
Copper Beech Farms in Greenwich, Conn., came on the market last week for $197 million. The 12-bedroom mansion is on just more than 50 acres, with 4,000 feet of water frontage on Long Island Sound and two islands offshore.
Previous homes listed in the $100 million range have sold for less or not at all. In 2006, for example, Saudi Prince Bandar bin Sultan listed a 90-acre ranch in Aspen, Colo., for $135 million. It sold last year for $41 million to hedge-fund executive John Paulson, according to The Wall Street Journal.
A mansion in Los Angeles listed in 2009 for $150 million by owner Candy Spelling was purchased for $85 million in 2011 by British heiress Petra Ecclestone. A Beverly Hills home formerly owned by newspaper magnate William Randolph Hearst was listed in 2007 for $165 million and is still on the market, with an asking price of $115 million.
Unique luxury properties have few comparables to test what the market will bear, so the true test of price is what the seller is willing to pay.
Keep up with your wealth and mortgages, and follow me on Twitter.
Get more news, money-saving tips and expert advice by signing up for a free Bankrate newsletter.


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They are a delight to read ! :)
Friday, 19 April 2013
MEMORIES OF GROWING UP IN HYDE Part 6
They are a delight to read ! :)
12 comments:
- downsie21 said...
Thank you Roger, your accounts are first class and your memory takes me back to those bygone years.
Happy days, but people pass you in the street today and don't look you in the eye and can't even bother to reply when you give the day's greeting.
- Friday, 19 April, 2013
Ibbotson's cafe - I'd forgotten about that. My favourite was the UCP though, as they served delicious braised liver! The bus fare in the 50s from the cemetery to the market was also 1d. I remember we were happy to walk down but preferred to get the bus back as it's a hell of a pull walking up that hill!
Many thanks again Roger for your memories - please can we have more?
- Friday, 19 April, 2013
- ceecee said...
Once again- very enjoyable reading. Would make a great book.
- Friday, 19 April, 2013
- jay johnson said...
I cannot tell you how much I have enjoyed reading your accounts. I am a Hyde girl born and bred. I wasn't born till 1948, but I remember many of the places you have spoken about. It would be so nice if you wrote an account and placed it in the archive at Ashton library. It is so informative. May I thank you from the family history buffs, it has given us so much. A truly magical walk through Hyde.
- Friday, 19 April, 2013
This is wonderful Roger, very entertaining and you made me laugh. You really should write a book you know, you have a real talent! Thanks Roger
- Friday, 19 April, 2013
Why Ashton Library? Recent posts here have commented how everything seems to have gone to Ashton since 1974 or else, as Eric Downs remarked, it has gone to pot. As I've said before, and so many others also, Roger's memories would make a wonderful publication which, hopefully, would be available to purchase, or if it could be recorded as a document, its place of safe keeping is at Hyde surely.
- Friday, 19 April, 2013
- jay johnson said...
How I agree with you that it should be kept in Hyde,but what would be wrong putting a copy in Ashton with all the other archival material. I know everything seems to be in Ashton library, at least it is in one focal point. The facilities keep the documents safe, and are there for everyone to enjoy. Don't get me wrong, I love Hyde as much as the next, but I would like to see our heritage preserved for future years and they have the facility to do it.
- Friday, 19 April, 2013
- Jeff Sherwin said...
I was born at Portland street Ashton,We moves in 1939 to Victoria Street Dukinfield, Dad came home in 1945, we moved to Gee Cross. After National Service with the Cheshire Regiment I married a Hyde girl, We had two children before moving to Canada in 1967. I return every few years, always with a Grand child or two, I check the site daily and am grateful to everyone involved.
- Saturday, 20 April, 2013
Our family lived at The Gardens (see this blog for history) and the nearest bus stop was Bennett St Bridge. My gran gave my dad (born 1923) a penny to keep in his pocket in case the weather turned bad as the bus fare from Flowery Field to Bennett Street was that same 1p so many of you to refer to. However you could go as far as the junction with Talbot Road for a penny so dad stayed on the bust to get his penny's worth and arrived home soaked. Children's economics :-)
Dave Davies
- Saturday, 20 April, 2013
- Jeff Sherwin said...
My brother Norman and I walked with our local shop keeper Mrs Goodwin from the Pancake at Hyde Junction to Sunday School at Flowery Field, One Summer Saturday she took us to a garden party there, I threw some bean bags into holes, just by luck I got a very high score, I watched for a long time but remained unbeaten. I ran home as fast as I could with two half crowns, mother was mad, thought I must have pinched them. it seemed like a lot of money.
- Saturday, 20 April, 2013
Barry in Oz. A good read. It gewts me thinking though that we as kids had the best of it, unlike the kids today. As a lad in Newton I roamed far and wide, either by myself or with mates, up Matley Lane, Hyde Park, Duckinfield, Down Commercial Brow, no parental controls or worries, played out in the street until Mum called us in for Bed. Happy days. Now parents seem frightened to let their kids out to play.
- Monday, 22 April, 2013
You're right, Barry, it was a different world in those days and kids were safe to wander. I think what summed it up for me was when, recently, I was out walking with my 11-year old granddaughter when a guy driving past stopped to ask for directions. I helped him and off he went. "Do you know that man" my granddaughter asked and when I said I didn't, her reply was: "Well, you shouldn't have been talking to him then." Bring back the good old times when there was trust and honesty and decency in the world.
- Wednesday, 24 April, 2013


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As if we didn't get our fill Tuesday evening at Vanity Fair's Tribeca Film Festival kickoff party, last night's NYC premiere of The Five-Year Engagement presented a bevy of cool red-carpet looks that ran the gamut from glamorous minis to chic floor-skimming numbers. The film's leading lady Emily Blunt stunned in an emerald-embellished Jason Wu cocktail dress, Olivia Wilde channeled a more exotic vibe in a Yigal Azrouël animal-print maxi dress, and Camilla Belle also opted for a sleek Wu creation, but in a formfitting gold metallic iteration. Suffice to say, it was a bold mix of Spring prints, colors, and silhouettes on display, and it's only day two of the Tribeca Film Festival. Click on for the complete red-carpet rundown, then tell us who earned best-dressed honors last night in the comments.
Celebrities at Five-Year Engagement NYC Premiere 2012
Emily Blunt, Olivia Wilde, and More Glam Up For the Five-Year Engagement Premiere — Who's Most Fab?
Image Sources: Film Magic, WireImage and Getty