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The performing arts. Joyful. Thought-provoking. Inspiring.
Education and Community Engagement programs are core to Des Moines Performing Arts' mission as a non-profit performing arts center. In fact, more than 70,000 people of all ages are impacted by the Des Moines Performing Arts' comprehensive education programs each year.
Public education programs allow audience members and local artists to make meaningful and personal connections to the art they experience on Des Moines Performing Arts' stages. Guest lectures, Q&As with company members, and other unique opportunities invite audience members to explore the inner workings of the performance. Des Moines Performing Arts also leverages its reputation of bringing the best of Broadway, dance, and the performing arts to Des Moines to provide local artists with invaluable training opportunities. Master classes, workshops, and summer camps give aspiring artists the chance to increase their skills by working directly with those who know what it takes to succeed on the professional stage.
Through its K-12 school programs, Des Moines Performing Arts strives to ensure that all central Iowa students have affordable access to high quality arts experiences as part of their education. 50,000 students and educators attend curriculum-connected school matinee performances at Des Moines Performing Arts through the Applause Series annually. In addition, Des Moines Performing Arts sends teaching artists into the schools to provide hands-on workshops and residencies in special opportunities that engage students directly in the creative process. Through its partnership with the John F. Kennedy Center, Des Moines Performing Arts provides teachers with in-depth professional development on how to use the arts in their classrooms to better impact student learning. The new Iowa High School Musical Theater Awards further celebrates the arts in Iowa schools, providing an unparalleled opportunity to honor students involved in their high school's musical production.
We are currently implementing an upgrade to our ticketing system. Ticketing is unavailable at this time. We expect to be back at 9:00am. Thank you for your patience.


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A Revolution At The Door
It is no exaggeration to say that network video has revolutionized the world of CCTV. Now the access control industry is on the verge of a similar, groundbreaking development. Once again, the driving force is the transition to TCP/IP-based systems.
Since the introduction of the first network camera by Axis Communications in 1996, digital network video surveillance systems have developed fast and now delivers a wide variety of advanced features that never could have been be attained by solely relying on analog technology. Today, distributors, integrators and, not the least, end users have come to expect a wide range of useful functionalities, such as remote accessibility, high image quality, event management and intelligent video capabilities along with easy integration, better scalability, greater flexibility and cost-effectiveness.
IP versus traditional access control
The migration of access control systems to a digital environment is sure to bring many comparable benefits, i.e. lowering installation costs, facilitating configuration and management, while simultaneously enhancing the versatility of the systems and opening up for integration with other security products.
Of course, IP-technology is not totally unknown to or unused in the access control industry. But existing systems have not been able to fully exploit the advantages of IP.
Download this white paper below to read more.

subset: commoncrawl


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A former San Jose State football player pleaded guilty today to a burglary spree that spanned four Bay Area counties and included the home of the late Steve Jobs, Apple's co-founder.
Kariem McFarlin, 35, of Alameda, was convicted of eight counts of residential burglary and one count of possessing stolen property, according to the Santa Clara County District Attorney's Office. McFarlien could face up to seven years and eight months in prison when sentenced on Jan. 17.
Police previously said McFarlin confessed to breaking into Jobs' Palo Alto home on July 17 and stealing a treasure-trove of goodies ranging from iPads to jewelry to kitchen blenders. He's also allegedly written a one-page letter of apology to Jobs' widow, Laurene Powell Jobs, after being arrested Aug. 2 in Alameda.
McFarlin has told detectives he was desperate and lived in cars before burglarizing four homes in San Francisco, then the Jobs residence, police said. McFarlin tried selling some of the lavish Tiffany & Co. jewelry from the home and gave iPads from the house to his daughter and to his friend, police said."
From at least March, 2011 to July, 2012, McFarlin targeted homes in affluent neighborhoods that appeared vacant while under construction or being remodeled, according to prosecutors. In addition to the Jobs' burglary, McFarlin admitted breaking into two homes in Marin County, four homes in San Francisco County and one home in Alameda County. He also admitted keeping hundreds of thousands of dollars worth of property, including computers, jewelry, furniture and a solid silver bar, at his home and storage locker in Alameda.
"This case can serve as a warning to families who may leave their homes for an extended period — either for vacation or while the home is under construction," Santa Clara County prosecutor Thomas Flattery said in a statement. "An empty, unprotected house is like low hanging fruit to thieves. Lock doors. Use alarms. Take precautions.
Contact Mark Gomez at 408-920-5869. Follow him on Twitter @MarkMgomez


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About Tesla
Tesla's goal is to accelerate the world's transition to electric mobility with a full range of increasingly affordable electric cars. California-based Tesla designs and manufactures EVs, as well as EV powertrain components for partners such as Toyota and Daimler. In Q1 of 2013 Tesla has delivered more than 10,000 electric vehicles to customers in 31 countries. Tesla's Model S is the world's first premium sedan designed and engineered from the ground up as an electric vehicle and was named Automobile Magazine's 2013 Automobile of the Year® and Motor Trend's prestigious 2013 Car of the Year®
The Role
Tesla Motors is committed to a policy of equal employment opportunity. We recruit, employ, train, compensate, and promote without regard to race, color, age, sex, ancestry, marital status, religion, national origin, physical or mental disability, sexual orientation, gender identity, medical condition, pregnancy, veteran status, genetic information or any other classification protected by state or federal law.
|Deer Creek, AR
United States
|Web Site:
|1050 Bing Street
San Carlos, CA 94070
United States
|Cleantech / Energy


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Meme Decorations
Stitch Yourself a Merry Little Meme
Stitch Yourself a Merry Little Meme
"Ho ho ho" turns into "ha ha ha" with the Internet Meme Ornament Kit ($12) by Subversive Cross Stitch. Socially Awkward Penguin, Business Cat, the always rambunctious Joseph Ducreux, and others make their mark in cross-stitch in the Ehmahgerd Ernaments DIY packs, which come with a color pattern, 18-count material, needle, 3.5-inch circular ornament, ribbon, and a set of instructions. Click on for more cross-stitched memes to can hang on the tree this holiday season.
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A 'Mason Storm' Moment
We've been raising cash for Action Alerts PLUS because we figure that stocks don't grow to the skies, and that's where they were headed. We bet that the Fed's outlook would be a good excuse for others to sell, and the uncertainty of Friday's employment number only gives you another excuse to ring the register.
I mean, you can only go up so much on the same news over and over -- and the news is fine, not blowout. We had a weak GDP number (that I explain away). We had earnings that are fine. We had housing that is fine. We had no growth in Europe -- and that is fine, too....215 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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Topic: New member
Hi, my name is Lizzy. My 56 year old Dad was diagnosed cholangiocarcinoma (distal bile duct carcinoma) at the end of May. I am living in CA but my parents are from Beijing, China. He had all treatments in Beijing.
I have been reading posts several days and get so much valuable knowledge and information. I wish to get your advice and help regarding my dad's post-surgery treatments. Thanks in advance!
Here is the treatments my Dad has received by far:
06/04: Whipple surgery
06/21: Discharge home with one abdominal drainage tube
06/26: One-day fever
06/26-07/02: Inpatient, diminish inflammation, blood test, CT scan
07/03: Remove the abdominal drainage tube
07/19: Blood test, all tumor marker indicators (AFP, CEA, CA199, CA125, CA153) are in standard range, except the Ferr is relatively high (577.32).
07/19-now: Inject thymopentin
Pathology (personal translation):
Distal bile duct poorly differentiated adenocarcinoma, 2*1*0.6 cm. Cancerous tissues invade throughout the bile duct wall layers, perineural invasion, invade surrounding pancreatic tissues, not involved duodenum. No cancer at duodenum incised margin, pancreas incised margin, common bile duct incised margin. Common bile duct cut edge epithelial displays adenomatous hyperplasia along with medium-severe atypical hyperplasia. No cancer metastasis at peripancreatic and peribilliary lymph nodes (respectively 0/1 & 0/2).
Our surgeon strongly recommends us to visit an oncologist so as to receive chemotherapy. I have consulted with two specialists. One advised to take chemo & radiotherapy together. Another specialist thinks cholanglocarcinoma is not sensitive to chemotherapy and there is no need to take radiotherapy either. So, we are very confused by their suggestion. We are wondering is it necessary to take chemo or radio or both therapies? Is it efficient to take the treatments after surgery?
Besides, I have red some academic articles both from Chinese and US journals. It is said the 5-year prognosis of poorly differentiated is 0. It is so horrible, scared, desperate, and hopeless! Anyone knows any exception? We look forward to a miracle!
So many questions! Thanks for any response!


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The Ridge Quilter's Guild wants to keep Ridge residents and visitors warm and comfy during the winter holidays. So the guild is hosting its bi-annual home tour next weekend to show off their homes and handiwork.
The guild alternates years between the tour and the bi-annual quilt show, with the tour happening during every odd-numbered year.
This year, three residents in Paradise and two in Magalia will open their homes to the public for the tour. The homes will be decorated for Christmas to help get visitors into the holiday spirit.
"People love to tour homes and it's a great way to kick off the Christmas holiday," said event organizer Ann Slocum. The Feather River Cancer center will also take part in the tour, but only on Saturday.
The event occurs every two years and grows a bit every year. Slocum said word of mouth spreads and people come from all over to enjoy the tour.
The tour is a fundraiser for the guild's comfort quilt program. Guild members make the quilts, which are donated to different local agencies such as Meals on Wheels, Feather River Hospital, the police and fire departments, local hospice and convalescent homes.
Slocum said the guild has donated 128 quilts, 77 placemats and 26 pillowcases in the past six months.
The guild also has an outreach program where members visit classrooms to teach children about the craft. Generally, the guild has students make a quilt block, which are then sewn together to create a finished quilt for the classroom.
At one of the homes - Slocum wanted to keep it a secret - there will be a boutique complete with everything from scarves and purses to jewelry. There will also be refreshments available.
The home tour addresses are located on the back of the tickets.
In all, there will be about 50 different quilts featured during the tour.
Slocum said the tour draws folks of all types.
"A lot of them are quilters that are looking at others' work," she said. Others enjoy the tour because it gives them a chance to look at the different home decorating ideas. And there are those who attend the tour because it has become a traditional way for them to start the holidays, Slocum said.
The Ridge Quilters Guild is a nonprofit organization dedicated to promoting quilting through education, exhibitions, programs and workshops.
The guild is also a philanthropic organization that aims to better the guild itself, the local community, the state and the nation.
The 100-member guild meets on the third Tuesday of the month from 10 a.m. to noon at the Paradise Senior Center on Nunneley Road. There are usually various speakers at the meetings and a workshop the following Wednesday.
The tour will take place on Dec. 7 and 8. Tickets are $10 and can be purchased in Paradise at Morning Star Quilts on Pearson Road, and Debbie's Quilt Shop on Skyway, and in Chico at Rabbit Hole.


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Goodwick United 5
Hundleton 0
STEPHEN Evans' superb hat-trick helped Goodwick United to an expected comfortable five-goal victory against relegation haunted Hundleton.
Lewis Banks opened the scoring with a thumping 15 yard volley. Evans then rounded the 'keeper that gave the hosts a two-goal cushion at half time.
Jac Pepper added the third with a header that was provided by a Stephen Evans cross. Evans added the fourth with an instinctive chip from 35 yards out and then completed his treble, curling an edge of the area shot in the bottom corner.
Goodwick United: James Gwilt, Anthony Couzens, Darren Devonald, Steve Blackford, Nigel Delaney, Lewis Banks, Jac Pepper, James Evans, Rhys Dalling, Stephen Evans, James Bottomley. Subs: Steff Hayes, Martin Griffiths, James Dean.
Hundleton: Dan Griffiths, Marc Edwards, Jack Richards, Shaun Donahoe, Gideon Hockin, Geraint Lewis, Lloyd Wilson, Scott Brunton, Thomas Powell, Jason Donahoe, Craig Manning. Subs: James Stanley, Johnny Hay.
Referee: Jeff Hurton.


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Paris -- French luxury group PPR's Tuesday announcement that it has acquired 51% of British fashion brand Christopher Kane means that the luxury designer will soon have branded boutiques. The first is slated to open in London as early as 2014.
According to a report by Reuters, the deal is part of PPR's strategy to add to its luxury portfolio with small brands that have growth potential.
"We think it can become a sizeable business," Alexis Babeau, managing director of PPR's luxury division, told Reuters on Tuesday.
PPR also owns French fashion brands Balenciaga and Yves Saint Laurent as well as Italian labels Bottega Veneta and Gucci.
Babeau said that the London opening will be followed by a planned network of shops.


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A gay Vietnamese-American coalition is fighting efforts to bar it from this weekend's annual Tet Parade in Orange County.
The Partnership of Viet Lesbian, Gay, Bisexual and Transgender Organizations has marched in past parades despite objections from religious groups.
The event was previously sponsored by the city of Westminster, but this year it is being run by a community federation, which fears other participants will pull out of Sunday's parade in Westminster's Little Saigon.
Spokesman Neil Nguyen tells the Orange County Register ( http://bit.ly/WR131d ) that the federation "regretfully" can't allow the coalition to participate.
An attorney for the coalition, Luan Tran, says he'll seek a court injunction to force organizers to let the group take part.
Information from: The Orange County Register, http://www.ocregister.com


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Hello, first time posting here.
I'm looking for a few particular discs...willing to pay cash or trade. Just let me know!
ANY Augusta Star Wraiths! I know these are hard to find, but surely someone has 1.
CFR Augusta Wraiths!
Pro line spiders...need these
Champion Classic Rocs
I'll be posting a trade list soon...


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And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
Some may call 'em drink stirrers, but we prefer to think of these bedecked birch straws as a mighty fine way to dress up a drink. Each one is even topped with a golden tassel and tiny pinecone, for good measure.
- Includes 12 drink stirrers
- Each one is 8" tall
This product ships from the maker within 7 days, via USPS
Full refund issued for items returned within 14 days of receipt


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International weed-resistance experts warn U.S. crop producers that herbicide-resistant weeds are aggressively taking hold in many parts of the country and pose a significant threat to U.S. crop productivity and profitability. As farmers in other countries have demonstrated, however, these so-called "monster weeds" can be controlled with a combination of conventional and nonconventional farming practices.
Four leading experts shared weed management observations and expertise during the "Weed Resistance in the Americas" panel at the 2013 Farm Progress Show. The event in Decatur, Ill., followed a week-long weed resistance tour of the U.S. and Canada hosted by Bayer CropScience. Panel participants included:
- Stephen Powles, director of the Australian Herbicide Resistance Initiative at the University of Western Australia;
- Aaron Hager, associate professor of Weed Science, University of Illinois;
- Pedro J. Christoffoleti, head of the Department of Crop Science at the University of São Paulo in Brazil; and
- Harry Strek, head of Profiling and Market Support in the Weed Control Biology Research group at Bayer CropScience in Frankfurt, Germany.
Moderator Arlene Cotie, product development manager with Bayer, said the panelists wanted to educate and urge growers to "take action" to protect their fields and yields.
"One of the greatest threats to yield loss and food security—on a local and global basis—is the development of herbicide-resistant weeds," Cotie said. "It is a growing global problem that is changing agronomic practices and threatens the long-term viability of economical weed control
and food production."
Global problem hits home
Resistance by weeds to the widely used herbicide glyphosate has grown over the past two decades. Earlier this year, the Stratus Glyphosate Resistance Tracking study found that nearly half of U.S. farmers surveyed in 2012 reported glyphosate-resistant weeds, up from 34 percent the prior year. Hager confirmed that Illinois farmland has experienced the continued evolution of herbicide-resistant weeds, including waterhemp and Palmer amaranth, which rapidly proliferate due to their biological characteristics and the lack of diversity in tactics used for their control.
"In the Midwest, we see new populations every season that demonstrate resistance to numerous herbicide classes," Hager said. "We find resistance is not necessarily limited to one herbicide, but in certain species we find resistance to multiple herbicides, effectively eliminating many of the options farmers would have to try to control these populations in their crops."
The Illinois agronomist and fellow panelists suggested that producers need to think about nonchemical methods to control weeds. "All of the solutions do not come out of a (herbicide spray) nozzle," Powles said.
The panelists cited diverse weed-management tactics including:
- In Australia, growers are adopting nonchemical means of managing weeds, such as using a seed destructor that is pulled behind a combine like a chaff cart at harvest time, destroying weed seeds as they exit with the chaff.
- Brazilian growers rely on double- and sequential-cropping to help manage weeds, something not possible in most areas of the U.S. due to the shorter growing season. They also use multiple herbicide modes of action.
- U.S. agronomists recommend controlling all weeds before planting a new crop, even if this slows the grower's planting schedule. In addition, Hager advocates managing weeds later in the season before they go to seed to prevent replenishment of the soil seedbank.
New thinking required
Bayer CropScience advocates similar practices through Respect the Rotation, an initiative that elevates the importance of grower adoption of herbicide diversity to reinforce the principles of Integrated Weed Management through rotation of crops, herbicide-tolerant traits and modes of action.
"Herbicide-resistant weeds are an unconventional threat to food production that we must fight with conventional and unconventional methods," said Bayer's Strek. "Accumulated resistance to multiple herbicides complicates the matter."
Bayer offers a number of solutions to weed resistance, including seed traits such as Liberty Link, allowing growers to spray Liberty herbicide in-crop for nonselective postemergence control of tough weeds.
Additionally, Bayer is working on additional herbicide systems and seed traits including:
- Balance Bean herbicide is an HPPD inhibitor that will offer a new mode of action for soybeans. As a burndown or pre- or postemergence product, it works on a broad spectrum of grasses and broadleaf weeds, and is intended to work with Balance™ GT soybeans. Balance Bean is expected to launch mid-decade, pending regulatory approvals.
- Balance GT is a double-herbicide-tolerant trait stack for soybeans developed in collaboration with MS Technologies. It features a new form of glyphosate tolerance for soybeans, coupled with tolerance to Balance Bean herbicide. Balance GT received cultivation approval from the U.S. Department of Agriculture in August 2013, making it one of the first dual-herbicide tolerant products for soybeans in the U.S. market. The first U.S. launch is planned for 2014 pending regulatory approvals.
- Bayer CropScience and Syngenta together have submitted applications for the approval of a new herbicide-tolerance soybean trait stack in various countries. The new trait stack confers tolerance to three herbicide active ingredients: mesotrione, glufosinate-ammonium and isoxaflutole (MGI). This trait will offer an important tool for soybean growers faced with challenging weeds and will broaden the herbicide options by offering tolerance to Balance Bean and Callisto herbicides, the leading HPPD inhibitor products. The trait is under review by regulatory authorities in the U.S. and Canada and key soybean-importing countries, including the European Union. The launch is expected between 2015 and 2020.
"These are new solutions that most of the weeds haven't seen before," Strek said. "But we don't want these solutions to burn out and become ineffective."
"Bayer wants to be a global leader not only in chemical solutions, but also in stewardship and education," he said. "We recognize that chemicals are often only a short-term solution. It's important to educate and train growers about future chemical and nonchemical tools for long-term sustainability of weed control technologies."
Visit here to learn more about Bayer's Integrated Weed Management solutions.


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Rolando McClain, the former Raiders linebacker who was the No. 8 overall pick in the 2010 NFL draft, informed the Baltimore Ravens that he's retiring at age 23.
"Rolando let me know that he plans to retire from the NFL," Ravens general manager Ozzie Newsome said. "We have placed him on the Reserve/Retired list."
McClain, who was a major disappointment on and off the field for Oakland, was released by the Raiders on April 5, but signed a one-year contract with the Ravens a week later.
Ten days later, McClain's string of off-field troubles continued when he was arrested in his hometown of Decatur, Ala. on charges of disorderly conduct and resisting arrest.
In 41 games with Oakland, McClain had 274 tackles, 6� sacks and one interception. In his final season, he was suspended for two games for conduct detrimental to the team.


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Please write your full name and e-mail to recive from us e-mails...
Size 4 cm
Sterling Silver Mezuzah Threads Necklace Shadi
Hebrew letters
The commandment to affix a mezuzah is widely followed in the Jewish world, even by Jews who are not religiously observant. We offer designing and producing mezuzah elevated to an art form over the ages. You can find here Mezuzot by an endless variety of materials, from silver and precious metals, to wood, stone, ceramics, pewter, and even polymer clay While the most important part for us is the parchment which we gurantee is valid.
Made By Israel Art Judaica Gifts


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Position Summary
Jaspersoft is seeking a talented troubleshooter with excellent communication skills. This is a hands-on support position focused on assisting customers with technical issue resolution and advice.
This individual will interact directly with customers to quickly troubleshoot mission critical issues, document product enhancements or defects, and explain best practices for implementation and usage of Jaspersoft products. Also, you will contribute valuable information to our growing self-service knowledge repositories. In addition, this individual will assist in identifying opportunities to increase the efficiency and effectiveness of the Technical Support team.
As a leading open source software company, Jaspersoft relies on the excellence of our support and services. We strive to innovate, and break the boundaries of traditional "support†to develop a leading model for Technical Support. . In recent years, Gartner (a market research company) has ranked Jaspersoft as high as #1 in customer support among Business Intelligence vendors â€" the individual filling this role will work within the Technical Support team to ensure that we continue this tradition of excellence.
Essential Functions
Job Requirements
Other Knowledge, Skills, and Abilities
Success Factors
|Texas, TX
United States
|Web Site:
|303 Second Street
Suite 450 North
San Francisco, CA 94107
United States


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#1: The Letdown!
Ok a week ago I checked to find a natural hairstylist in my area and was so indecisive so I found a number to a women who did my hair a while back number was no longer good so called salon she had worked in well the owner said she had been gone a while but what was I looking to do so I explained I have been transitioning for a year & 3 months and I wanted to finally cut off the relaxed hair she so oh ok well I do natural hair, did you want a blow dry and to straighten the hair, I replied no I want it naturally curly she said I would like to see the texture of your hair OK went for appt. and she wash my hair and told me before she began to blowdry she says you just have barely bit of relaxer, will cut after blowdry and then she hit me your texture is like mines and the curly effect you want to have you will not be able to achieve! WOW! that hurt! then she says I will blowdry and flat iron hair it will be as if you had a relaxer, Now I never said I wanted a relaxed look but any how I've decided to wash on my day off and apply some curly styling products and see for myself if I can actually achieve the way I want to wear my hair!!!! Wish me Luck!!! if any products or tips feel free to respond please!! Help a Newbie out!!!!


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I've been generally cautious on this multi-month equity rally but, like all good investors, I am keeping an open mind to the opposing case. My concern has been that the lurch upward hasn't been accompanied by anything other than mediocre fundamentals. If stocks are rip-roaring higher, I want to see earnings getting substantially better, for instance. Instead, earnings are stable at best -- and rising interest rates do not auger for higher valuations.
However, one key point I often make is that the stock market is, in reality, a barometer of precisely current conditions. Often a move in a stock or the broad market seems mysterious until later -- when, for example, a company reports great earnings or a takeover is announced. Current information is leaking into the market at a constant rate, so the rally could be reflective of earnings trends that will become apparent only on first-quarter earnings calls in April or May -- or maybe not. But we investors must be open to that possibility, and recheck our theses often.
I do sense an undercurrent of distrust in the rally -- which, counterintuitively, could be bullish -- in the violence of these occasional selloffs, such as Monday's big decline on news out of Italy. These moves remind me very much of the huge one-day rallies that punctuated the long bear markets in 2000 to 2002 and 2007 to 2009. Back then, every so often the market would be up 2% or 3% on a single day, signaling an underlying hope that the bear market was over -- but then the march downward would quickly resume. We are seeing the mirror opposite now: These occasional selloffs mark intense distrust, and then the upward climb continues.
So, in the spirit of keeping an open mind here, I'll go over a solid bull case made this week by eminent market strategist Jeff Saut of Raymond James. Here is the summary of his points:
â—Ź Saut is looking for an end to this "buying stampede," marked by 37 straight-up sessions, but he believes the bull market will resume after a modest correction.
â—Ź Two technical indicators, buying power and selling pressure, are not signaling a major top.
â—Ź The NYSE advance-decline line traded to new highs, confirming upside.
â—Ź Major averages are safely above their 50-day and 200-day moving averages, and those lines are rising.
â—Ź Berkshire Hathaway (BRK.A), a proxy for confidence in the economy, is making new highs.
â—Ź Despite softness in multifamily homes, single-family-home sales are up and inventories down, setting up that important sector for more growth.
â—Ź History shows that the longer a year-end rally carries into the new year, the better the year is, on average. That would set up 2013 to be a banner year.
A high reliance on the technicals, as Saut sees them, would argue for the rally to continue. I am less technically oriented than many of our subscribers are, but I still pay attention to them, since they can sometimes be self-fulfilling. In any case -- or, should I say, in all cases when investing -- caution is warranted. Whatever your current thesis is, keep an eye on the opposing case. Sometimes they are right!


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Welcome to Chalice Consort! We are on the hunt for missing "pieces" of early music history in alignment with our mission.
NEWS! Chalice Consort is named Artist in Residence at The Cathedral of St. Mary of the Assumption. The residency reflects a shared goal of the choir and the cathedral: bringing centuries-old traditions to life in a modern setting. You can read more about it here.
The members of Chalice Consort are musicians, shaking up the world of early music, and we invite you to support us in any amount.
Click here to donate any amount today! We appreciate your support!
Thank you for your interest in Chalice Consort! If you would like to be on our news and announcements email list, sign up here.
(Photo taken by Stephen Saxon 2010)
Back row (from left): David Wake, Julio Ferrari, Jeff Phillips, Celeste Winant
Middle row: Nick Kotar, Rebekah Wu, Clarence Wright, Michelle Clair
Front row: Jamie Apgar, Lindasusan Ulrich, Davitt Moroney
© Chalice Consort 2010


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Friday, September 22, 2017
Prostate Cancer
Increase in PSA with Negative Biopsies
I have had 5 Biopsys all have come back negative for prostate cancer. My PSA has gone from 3.5, 7 years ago to my latest of 10.3. My last biopsy was done when my PSA was at 7.3 1 year ago. 3 months after my last biopsy my PSA was 8.8. 8 months later it is 10.3. Are 5 biopsies enough or should I keep on getting biopsies as my PSA elevates. I am 58 yrs.
Sorry for missing this one.
According to your information you do seem to have a significant rate of rise of PSA (PSA velocity) over the last year, though it has not doubled. The concern with such a situation is whether this rise is due to prostate cancer. In a scenario as yours where several previous biopsies have been negative, the decision as to when to rebiopsy is not clearly defined and is usually made in relation to the existing clinical circumstances. One thing to rule out would be other causes of PSA rise such as urinary infection. It would also be important to note the digital rectal prostate exam findings and whether there has been any interval change in this. A free/total PSA ratio is another test which can sometimes help in such situations where a ratio <0.25 is more suggestive of malignant disease (these values are again variable).
If you decided to proceed with a biopsy, I feel it would be worth performing a saturation biopsy (samples a significantly larger area of the prostate than a standard biopsy) and a biopsy of the transitional zone of the prostate (if this has not been done already). I am not sure what the indications for your previous repeat biopsies were, but but rate of rise is an important factor that should be considered besides the absolute PSA value.
I would recommend that you have a detailed discussion with your urologist regarding the above mentioned issues as there is no one right answer to this situation. I hope the information above helps you make a informed decision along with your physician, regarding further biopsy.
Krishnanath Gaitonde, MD
Assistant Professor of Clinical Urology
College of Medicine
University of Cincinnati


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Free weekly email packed with travel tips for major world cities, great competitions and exciting features.
Despite its proximity to Europe – just 8.5 miles separate Tarifa in Spain from the Moroccan coast – Africa is far less popular with British and European travellers than faraway lands in the US, Latin America and Australasia. But the continent is vast and there are many fabulous and thrilling countries where tourism is easy and as safe as in any of the more obvious, mass-tourism destinations.
The archipelago of Cabo Verde is the thinking traveller's Canaries. The bone-white, empty beaches, soaring volcanoes and lush tropical vegetation on these ten islands were kept a secret for years (although Cabo Verde always attracted a few Portuguese holidaymakers, thanks to the colonial connection), but now the year-round sun and unique blend of African, Portuguese and Brazilian cultures is even attracting package tourists.
The archipelago – ten islands and eight islets – is located 604 kilometres off the coast of West Africa. Visit Sal, famous for its 350 days of sunshine, one of the most popular resort hubs thanks to the lovely beaches of Santa Maria; on Boa Vista you can climb stunning dunes and dive to see marine turtles, and explore the 'tropical Lisbon' of Sal Rei, with its cobbled streets. Santo Antão is developing rural tourism, great if you want to meet locals and get away from the beaches. Santiago, in the leeward island chain to the south, is best known as the island where Darwin made landfall during his epic Beagle voyage.
Book with Thomson (0871 231 4691, www.thomson.co.uk).
Fes has a wonderful, labyrinthine medieval souk and, being far less touristy than Marrakech, is sometimes described as the 'real Morocco'. The city is famous for its Arabesque architecture, and the city's medina of Old Fes (Fes el Bali), a UNESCO World Heritage Site, is thought to be the world's largest contiguous car-free urban area. You'll probably want to get behind those glorious Arabesque façades: the recent conversion of many of the smarter traditional houses (riads) into hotels means you can recharge your batteries in luxurious comfort before heading out into the whirl of people, goods and overburdened donkeys thronging the centre.
Book with Fleewinter (020 7112 0019, www.fleewinter.co.uk).
You can see gorillas in the mist, hippos surfing the waves and whales in the same day on a holiday to Gabon. This small West African country on the Gulf of Guinea is blessed with some of the most diverse tropical forest in the world – ancient jungles straddling the equator that are believed to contain more than 8,000 plant species, 600 different types of bird and 20 species of primate. Outsiders and locals hope Gabon will become the 'Costa Rica of Africa', attracting wildlife and adventure tourists to its 13 new national parks: some 85 per cent of the country is covered in tropical forest, and away from the few small population hubs are savannahs, mangroves, lagoons and beaches. There are thought to be about 20,000 western lowland gorillas and 60,000 forest elephants – the largest population in Africa.
Book with Steppes Travel (01285 880980, www.steppestravel.co.uk).
The Gambia is a great destination for a winter-sun holiday, and is good value for money. The country's small size and the friendliness of its people are strong draws, and visitors can choose between a blissful do-nothing-at-all beach holiday and exploring the culture. There are many tribes – the main ones are Mandinka, Wolof, Fula and Jola – and it's common to receive an invitation to visit a Gambian settlement or 'compound'.
Book with The Gambia Experience (0845 330 2060, www.gambia.co.uk).
US president Obama chose Ghana in July 2009 as the first African country worthy of a presidential visit, praising its democratic traditions since independence in 1957. Accra, the capital, is vibrant, swinging to the music of Highlife and the more recent hip-hop fusion Hiplife; it's more modern than many people expect (Time Out even publishes a Visitors Guide there). The interior is varied and ideal for voluntourists and adventure travellers: visit Ho and its game park to see kobs, duikers and baboons, go mountain biking to the villages of Biakpa and Amedzofe, and hike through the Kulugu canyons to the Mountain Paradise ecolodge (www.mountainparadise-biakpa.com).
Book with Responsible Travel (www.responsibletravel.com).
A trip to Lybia should definitely take in Tripoli, with its world-class Jamahiriya Museum – one of the finest collections of classical art in the Mediterranean – and impressive medina. Out of town, see the rock carvings of Wadi Methkandoush, and Akakus, a mountain range known for its gorgeous red sand and extraordinary rock formations. There are Roman archaeological sites all over Libya but Leptis Magna is the best preserved Roman city in
North Africa, with a stunning location on the shores of the Mediterranean.
Book with Kuoni (01306 747002, www.kuoni.co.uk) or Explore (0845 013 1537, www.explore.co.uk).
For wildlife, southern Africa reigns supreme. Namibia is wonderful for lion-, cheetah-, rhino- and leopard-spotting, and has the world's highest dunes and second deepest canyon. It's a country with huge geographical variety, containing a large part of the Kalahari Desert in the east of the country. In the north is the Etosha Pan, a verdant, game-rich area with a huge range of species. The Namib Desert and Skeleton Coast lie along the western seaboard, while the Caprivi Strip is a dramatic, 280-mile-long sliver of Namibia between Botswana on the south and Angola and Zambia to the north that provides access to the Zambezi and the habitat of the endangered Wild African Dog.
World music fans are already flocking to Mali for the annual Festival au Desert, a three-day celebration of song and dance (www.festival-au-desert.org) that takes place in Essakane. If you're after a real out-there experience, travel along the Niger River to Timbuktu and visit Dogon villages that have remained unchanged for centuries.
Between Guinea-Bissau and Mauritania, Senegal is Africa's most westerly point. It boasts three mighty rivers, which provide plenty of fertile land and some shimmering coastal lagoons, and support a variety of waders and birds of prey as well as hyenas, monkeys, baboons, manatees and dolphins.
Book with The Senegal Experience (0845 330 2080, www.senegal.co.uk).
South Africa offers the opportunity to see the Big Five (lion, leopard, elephant, buffalo and rhino), as well as the chance to sample excellent wines in the Cape regions of Stellenbosch, Paarl and Constantia.
Book with Expert Africa (020 8232 9777, www.expertafrica.com), Wild about Africa (020 8758 4717, www.wildaboutafrica.com), or Safari Africa (01488 71140, www.safaridrive.com) for self-drive safaris.
Find out about hotels, restaurants, attractions and more in our online Cape Town city guide.
Plan your perfect trip with this inspirational compendium of failsafe holiday suggestions. It's packed with fresh ideas for traditional breaks, from beach idylls to winter sun and family camping, along with great suggestions for trying something different – all around the world. Whether you're looking for a weekend break or the trip of a lifetime, Time Out's worldwide team of travel specialists can take you there.
Buy '1000 Great Holiday Ideas' from the Time Out shop for the discounted price of £7.99.
For more of Earth's most exciting travel experiences, pick up a copy of our guidebook 'Adventure', available from www.timeout.com/shop for just £13.59.
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If life is a battery then holidays is a great way to charge it.People willingly pay huge amount of money for their vacations.There are many places around the globe for vacations.I have read about some of the amazing places for holiday vacation in a popular Australian magazine some places are in Africa . Can you provide me the details of those places. this could be helpful :http://www.billionairesnewswire.com/best-holidays-world/
Namibia sounds like a lot of fun. Definitely wanted to get the entire safari experience you see in movies.
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text:
Current Articles
Nagoya, Japan (CBD) - The Niger River is a lifeline for the Sahelian countries of Mali and Niger. Depending on the rainwater in Tropical West African Country of Guinea, the river fills the large Inner Niger Delta; a seasonal flooded area for one million people and millions of migratory waterbirds. A combination of upstream dams and expected climate change impacts may mean a disaster for these biodiversity and human values.
Today, the report "Will the Inner Niger Delta shrivel up due to climate change and water use upstream?" is presented in a CBD side event of Wetlands International, the NGO that commissioned the study. The report shows how this large wetland area is already under threat due to water consumption upstream.
Dams for hydropower and irrigation schemes already cause a reduction in the size of the seasonal flooded area. This is already impacting the life of one million herdsmen, fishermen and farmers that depend on the seasonally flooded areas.
Climate change: worsen situation
Looking at possible impacts due to climate change in the future, this situation may worsen a lot. In dry years with less rainfall and more evaporation due to higher temperatures, the dam lakes still need to be filled. This will lead to the use of a disproportional part of the water for the upstream water infrastructures. As a result, the seasonally flooded area will become very small. In this way, dams are making drought events more extreme.
More examples
The Inner Niger Delta is unfortunately not a standalone example. Similar stress is seen on other wetlands in the Sahelian zone, with Lake Chad as a well known example.
Presentation of the report:
Convention on Biological Diversity, Nagoya, Japan (CBD COP 10)
Side event: "Wetlands, Water, Livelihoods and Biodiversity Linkages in a Global Water Crisis"
20 October 18.15. Room 136 - Bldg 1 - 3rd Floor
Presentation by Papa Mawade Wade, Wetlands International Africa
For more information:
Fatim Sow
Communication and Media Coordinator
Wetlands International Africa
Alex Kaat
Global Communications Manager
Wetlands International
Tel. +31 (0) 640501917
More resources:
Impact of Dams on the People in Mali (booklet)
Better use of the water of the Inner Niger Delta in a Changing Climate(video)
The Niger, A Lifeline (book)
Biodiversity loss and the global water crisis - A fact book (booklet)
Our work in the Inner Niger Delta (page on our site)
Phone: +221 33 869 16 81


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Understanding the Role of Genes and Biomarkers in the Blood Clotting Process in Children With Acute Lung Injury (PALI)
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- No Study Results Posted
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- How to Read a Study Record
|Respiratory Distress Syndrome, Adult
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Targeted Genomic Analysis of Coagulation Pathways in Acute Lung Injury
- Number of ventilator-free days [ Time Frame: Measured during participant's hospital stay ]
- Mortality and organ dysfunction [ Time Frame: Measured during participant's hospital stay ]
Biospecimen Retention: Samples With DNA
|Estimated Enrollment:
|Study Start Date:
|November 2007
|Estimated Study Completion Date:
|December 2016
|Estimated Primary Completion Date:
|December 2016 (Final data collection date for primary outcome measure)
ALI/ARDS is a life-threatening condition that involves inflammation of the lungs and fluid accumulation in the air sacs, which leads to low blood oxygen levels and respiratory failure. Common causes include pneumonia, sepsis, and lung trauma. Symptoms, including breathing difficulty, low blood pressure, and organ failure, usually develop within 24 to 48 hours of the original injury or illness. Most patients require immediate care in an intensive care unit, and the main form of treatment is mechanical ventilation, which delivers oxygen and a continuous level of pressure to the damaged lungs. Although progress has been made in understanding how ALI/ARDS develops, it is still unknown why recovery outcomes differ among people. Differences in the genetic basis of protein C and fibrinolysis pathways, which both play a role in preventing blood clots, may be a factor in determining the severity of and recovery from ALI. The purpose of this study is to analyze plasma and DNA from children with ALI/ARDS to identify biomarkers and genetic variations that may be related to clinical outcomes.
This study will enroll children who are hospitalized with ALI/ARDS. Participants' medical records will be reviewed to gather information about symptoms, physical exam findings, mechanical ventilator settings, and laboratory test results. A blood collection will occur on Days 1 and 3. Study researchers will analyze plasma biomarkers and use high throughput DNA sequencing technology to analyze participants' DNA.
|Ages Eligible for Study:
|up to 18 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- Hospitalized and requiring supplemental oxygen
- Meets the American-European consensus definition of ALI/ARDS, defined as partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO2/FiO2) ratio of less than 300 mm Hg, bilateral opacities on a chest radiograph, and either a pulmonary wedge pressure of less than 18 mm Hg or the absence of clinical evidence of left atrial hypertension
- Acute pulmonary parenchymal disease (i.e., onset of bilateral infiltrates on chest radiograph within 48 hours of screening)
- PaO2/FiO2 less than or equal to 300 mm Hg, regardless of the mean airway pressure
- At least one arterial blood gas confirming partial pressure of oxygen/fraction of inspired oxygen (PO2/FiO2) ratio less than 300 mm Hg or Fi02/Sao2 on pulse oximetry of less than 320
Exclusion Criteria:
- Clinical signs of left ventricular failure, pulmonary capillary wedge pressure greater than 18 mm Hg, or evidence, such as echocardiography, suggesting a cardiac basis for the pulmonary edema
- Presence of right-to-left intracardiac shunt
Please refer to this study by its ClinicalTrials.gov identifier: NCT00605527
|Contact: Anil Sapru, MD, MAS
|United States, California
|Children's Hospital Central California
|Fresno, California, United States, 93710
|Children's Hospital Los Angeles
|Los Angeles, California, United States, 90027
|Contact: Robinder Khemani, MD 323-361-2557
|Principal Investigator: Robinder Khemani, MD
|Children's Hospital & Research Center of Oakland
|Oakland, California, United States, 94609
|University of California, San Francisco
|San Francisco, California, United States, 94143
|Contact: Anil Sapru, MD, MAS 415-476-0963 firstname.lastname@example.com
|Principal Investigator: Anil Sapru, MD
|United States, Wisconsin
|American Family Children's Hospital
|Madison, Wisconsin, United States, 53792
|Principal Investigator:
|Anil Sapru, MD, MAS
|University of California, San Francisco
|Responsible Party:
|University of California, San Francisco
|ClinicalTrials.gov Identifier:
|NCT00605527 History of Changes
|Other Study ID Numbers:
K23HL085526 ( U.S. NIH Grant/Contract )
K23HL085526-01A1 ( U.S. NIH Grant/Contract )
|Study First Received:
|January 18, 2008
|Last Updated:
|October 30, 2015
Keywords provided by University of California, San Francisco:
Acute Lung Injury
Acute Respiratory Distress Syndrome
Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Respiratory Tract Diseases
Lung Injury
Lung Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Thoracic Injuries
Wounds and Injuries
ClinicalTrials.gov processed this record on September 25, 2017


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Home diagnosis: always a train wreck for veterinarians
Mr. Mortis was in a state of sheer panic. "Something has gone terribly wrong, Doc! Riggy is curled up under the sofa. He won't move and his pupils are dilated. I'm afraid he may be dead!" Riggy Mortis had been discharged from my clinic just three hours earlier. Phone calls like this one are often just as upsetting for me as they are for the client.
"I don't know what may have gone wrong," I told the client. "Can you bring him right over to the clinic so I can see what happened?"
"No way, Doc. I tried to reach under there just now and he darn near took a piece out of my hand."
You see, strange things can happen when our clients try to diagnose on their own. Mrs. Downer is a great example. She was aghast concerning my postoperative instructions for her dog, Dozey.
"What? You aren't going to put him on pain medicine! That's outrageous! He just had real surgery with stitches and everything. When I had surgery I was on Narcoset for a month. Dozey is very sensitive. I think he needs pills."
I assured her that Dozey's one-stitch surgery did not call for analgesics and sent her home. Of course, she was back the next day.
"This dog was perfectly healthy when I brought him in here. Now all he does is mope around. My neighbor says that you should have known better than to use anesthesia on a sensitive dog like him. He's still groggy from your anesthesia. I ought to sue you!" (FYI, the surgery was done with local analgesia.)
I checked him out. Dozey seemed fine but acted groggy. Mrs. Downer's next words clued me in. "You don't think it could be the drugs, do you, Doctor? You see, you weren't going to give him anything for the pain, so I gave him a few aspirin when we got home. Then I remembered hearing somewhere that aspirin isn't good for dogs. So I gave him one of those Narcosets that I had left over from my surgery. I threw in a Somnium tablet to help him sleep also."


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HOUSTON - The Israeli-Palestinian conflict is taking place more than 6,000 miles away from Houston, but for one woman, the rising tensions overseas hits very close to home.
"It does, but I have a lot of faith," said Ellen Buchine.
Buchine's 20-year-old son, Jesse, a Houston native, has been serving alongside Israel's military forces since March. He joined first as a volunteer but this summer he became a dual citizen. Buchine said that was a decision she whole heartedly supports.
"He didn't want to take Israel for granted as his emotional and spiritual home. He felt should something happen, he should defend her," Buchine said.
Buchine's son is one of at least 10 Robert Beren Academy graduates from the Houston area who've joined the Israeli military. Buchine, a teacher at the school, said students gain a love for Israel early on, so much so, that by the time they graduate it becomes a part of them.
Gal Benmeir, a fellow teacher at Beren, agrees. He says there were quite a few Americans in his platoon.
"It's about heritage, about wanting to be connected to the people, to the Israeli's in particular, to the culture and sort of wanting to work on the differences and also to learn from each other," Benmeir said.
Buchine said she talks to her son at least twice a week. A lot of people ask her if she's constantly worried about his safety. Her response is usually always the same.
"You know what, people can get in harm's way anywhere in America," Buchine said.
Copyright 2012 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text: LeBron James either hasn't eaten since he's lost his third NBA Finals, or he's on a drastic diet. King James posted a picture on his Instagram that made the normally chiseled-looking forward into a skinny, lanky point guard. According to Dan Feldman of Pro Basketball Talk, James apparently has cut out carbs in his diet. Maybe this would explain the picture below.


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NEW YORK — Build-A-Bear CEO Maxine Clark has joined the Foot Locker board of directors.
Clark founded Build-A-Bear Workshop in 1997. She has extensive experience in the retail industry, having also served as president of Payless ShoeSource Inc. and for 19 years as an executive of The May Department Stores Company.
"Maxine Clark has a depth of experience in both domestic and international retailing, and she is well-known for her innovative approach to the industry," said Ken Hicks, hairman of the board and CEO of Foot Locker Inc. "We are pleased to be adding an individual with her talent and expertise to complement our already strong board of directors."


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Hollis-Jefferson, van Grinsven, Baron named Big 5 players of the week
February 25, 2013
PHILADELPHIA, Pa. - Rahlir Hollis-Jefferson of Temple was named the Big 5 Men's Player of the Week while Chatilla van Grinsven of Saint Joseph's and Alyssa Baron of Penn shared Big 5 Women's Player of the Week honors.
Hollis-Jefferson set new career-highs in points (23) and rebounds (18) in helping the Owls to an 82-74 win over La Salle and a share of the Big 5 Championship. He made 9-of-14 shots from the floor and also dished out a game-high five assists versus the Explorers. In a victory over Charlotte, he notched eight points, five rebounds, three assists, three blocks, and three steals.
Averaging 21 points and 14 rebounds in a pair of games, van Grinsven posted 16 points and 15 boards in a Big 5 victory over La Salle. In an overtime setback to Fordham later in the week, van Grinsven notched her 1,000th career point and finished the contest with 26 points and 13 rebounds. She made 53.1% of her shots (17-of-32) and also averaged 2.5 assists for the week.
Baron averaged 16 points, 8.5 rebounds, and 6.5 assists in a 2-0 week for the Quakers. Against Cornell, she netted 11 points to go along with eight rebounds and six assists. She nearly recorded a triple-double against Columbia, scoring 21 points on 9-of-11 shooting, grabbing nine boards, and handing out seven assists. She also swiped four steals.
Men's Honor Roll


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Curbside pick-up
You no longer need to remove objects from your tree if you don't want to. Whole Christmas trees can be placed curbside with your regular trash and will be collected for use in the city's bioreactor landfill. In the bioreactor, liquid is added to accelerate the decomposition and stabilization of the waste. Methane produced will be used to generate electricity from this renewable energy source. After January 31, trees placed curbside need to be cut into four-foot lengths and bundled.
Drop-off locations
Christmas trees can also be dropped off at the Capen Park Mulch Site (south of Stadium, off Rock Quarry Road) OR the Parkside Mulch Site (north of Memorial Park Cemetery, off Creasy Springs Road). ALL lights, ornaments and stand must be removed prior to deposit at these two sites.
For more information, call the Public Works Solid Waste Division at 573-874-6291 or send an e-mail to firstname.lastname@example.com.


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Efficacy and Safety of Vildagliptin as add-on Therapy to Metformin in Patients With Type 2 Diabetes
This study has been completed.
Novartis Pharmaceuticals
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
First received: December 20, 2011
Last updated: February 23, 2017
Last verified: February 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of the study is to evaluate the efficacy and safety of vildagliptin 50 mg bid as an add-on therapy to metformin in Japanese patients with T2DM. This study is being conducted to support registration of the fixed-dose combination of vildagliptin and metformin for the treatment of Type 2 diabetes mellitus (T2DM) in Japan.
|Diabetes Mellitus, Type 2
|Drug: Vildagliptin Drug: Placebo
|Phase 3
|Study Type:
|Study Design:
|Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Multicenter, Double-Blind, Randomized, Parallel-Group Study to Compare the Effect of 12 Weeks Treatment With LAF237 50 mg Bid to Placebo as Add-On Therapy in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy
Resource links provided by NLM:
Drug Information available for: MetforminU.S. FDA Resources
Further study details as provided by Novartis ( Novartis Pharmaceuticals ):
Primary Outcome Measures:
- Change from baseline in glycosylated hemoglobin (HbA1c) at 12 weeks between treatment groups [ Time Frame: Baseline to 12 weeks ]HbA1c will be performed on a blood sample obtained by study personnel and measured by high-performance liquid chromatography (HPLC) performed at a central laboratory.
Secondary Outcome Measures:
- Change from baseline in HbA1c at 12 weeks within subgroups of metformin doses [ Time Frame: Baseline to 12 weeks ]HbA1c will be performed on a blood sample obtained by study personnel and measured by high-performance liquid chromatography (HPLC) performed at a central laboratory.
- Change from baseline in Fasting plasma glucose (FPG) at 12 weeks [ Time Frame: Baseline to 12 weeks ]FPG will be performed on a blood sample obtained by study personnel and analyzed at a central laboratory.
- Percentage of patients meeting Responder rates in HbA1c [ Time Frame: 12 weeks ]
Responder rates will be categorized by predefined HbA1c value at 12 weeks :
- Endpoint HbA1c ≤ 6.5%
- Endpoint HbA1c ≤ 7%
- Endpoint HbA1c ≤ 7% in patients with baseline HbA1c ≤ 8%
- Number of patients with adverse events (including hypoglycemia), serious adverse events and death [ Time Frame: 12 weeks ]The occurrence of adverse events will be sought by non-directive questioning of the patient at each visit. Adverse events are defined as appearance or worsening of any undesirable symptom, sign (including an abnormal laboratory finding), or medical conditions. Serious adverse events are any untoward medical occurrences that result in death, are life threatening, require (or prolong) hospitalization, cause persistent or significant disability/incapacity, result in congenital anomalies or birth defects, or are other conditions which in judgment of investigators represent significant hazards.
|Study Start Date:
|December 2011
|Study Completion Date:
|February 2013
|Primary Completion Date:
|February 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Vildagliptin
In addition to their stable dose of metformin monotherapy, patients should take vildagliptin 50 mg twice daily.
Drug: Vildagliptin
vildagliptin 50 mg twice daily
Other Name: LAF237
Placebo Comparator: Placebo
In addition to their stable dose of metformin monotherapy, patients should take vildagliptin matching placebo.
Drug: Placebo
Matching Placebo of vildagliptin 50 mg twice daily
|Ages Eligible for Study:
|20 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with type 2 diabetes inadequately controlled with diet, exercise and oral anti-diabetic therapy.
- HbA1c in the range of 7.0-10.0%
- Body mass index in the range 20-35 kg/m2
Exclusion Criteria:
- Type 1 diabetes, diabetes resulting from pancreatic injury, or secondary forms of diabetes
- Significant heart diseases
Other protocol-defined inclusion/exclusion criteria may apply
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01497522
Please refer to this study by its ClinicalTrials.gov identifier: NCT01497522
|Novartis Investigative Site
|Kitakyushu, Fukuoka, Japan, 800-0296
|Novartis Investigative Site
|Kurume, Fukuoka, Japan, 830-8543
|Novartis Investigative Site
|Ohkawa-city, Fukuoka, Japan, 831-0016
|Novartis Investigative Site
|Kawasaki-city, Kanagawa, Japan, 210-0014
|Novartis Investigative Site
|Yokohama, Kanagawa, Japan, 221-0802
|Novartis Investigative Site
|Kyoto-city, Kyoto, Japan, 615-0035
|Novartis Investigative Site
|Takatsuki, Osaka, Japan, 569-1096
|Novartis Investigative Site
|Ageo-city, Saitama, Japan, 362-8588
|Novartis Investigative Site
|Bunkyo-ku, Tokyo, Japan, 113-0031
|Novartis Investigative Site
|Edogawa-ku, Tokyo, Japan, 134-0084
|Novartis Investigative Site
|Hachioji, Tokyo, Japan, 192-0046
|Novartis Investigative Site
|Kiyose, Tokyo, Japan, 204-0021
|Novartis Investigative Site
|Minato-ku, Tokyo, Japan, 105-7390
|Novartis Investigative Site
|Minato-ku, Tokyo, Japan, 108-0075
|Novartis Investigative Site
|Nerima-ku, Tokyo, Japan, 177-0051
|Novartis Investigative Site
|Shinagawa-ku, Tokyo, Japan, 141-0032
|Novartis Investigative Site
|Toshima-ku, Tokyo, Japan, 171-0021
|Novartis Investigative Site
|Fukuoka, Japan, 810-0001
|Novartis Investigative Site
|Fukuoka, Japan, 819-0168
|Novartis Investigative Site
|Kyoto, Japan, 607-8062
Sponsors and Collaborators
Novartis Pharmaceuticals
|Study Director:
|Novartis Pharmaceuticals
|Novartis Pharmaceuticals
More Information
Additional Information:
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 20, 2017
Additional Information:
|Responsible Party:
|Novartis Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT01497522 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 20, 2011
|Last Updated:
|February 23, 2017
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Type 2 diabetes
Fasting plasma glucose
Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs
Dipeptidyl-Peptidase IV Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 20, 2017


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TEAC AG-H380 and PSB Image B5 speakers -- small system, big sound
Dave Bar worked for Crutchfield from 1981 until his retirement in 2016. After a 23-year stint in the sales department, he joined the home A/V writing staff. Dave's expertise and good humor will be sorely missed.
More from Dave Bar
Heads up!Welcome to this article from the Crutchfield archives. Have fun reading it, but be aware that the information may be outdated and links may be broken.
In the audio world, sometimes it's the little things that deliver the biggest surprises — like tiny in-ear headphones with mind-bending sound, or a portable USB DAC that wrings fresh new details from long-familiar recordings. But all too often mini components can measure up a little short in the sound department. That's not to say there aren't any that sound good in smaller rooms like a den or bedroom. And I've even been surprised a time or two by small high-end components capable of shaking the rafters (along with most of the money out of your piggy bank!). But for the most part, someone looking for the big sound has had to deal with big components and big price tags.
So what's a space-challenged music lover on a budget to do?
That question was answered here recently when TEAC dropped by to show us their line of compact receivers and other assorted mini components. Our TEAC rep, Fred, is a knowledgeable guy with many years of experience in the audio biz, especially in high-end gear. So when he shows up on your doorstep with some cool new toys, you'd better pay attention because you know it's going to get interesting.
Fred started his presentation by pointing out TEAC's long-time standing in the professional music world, as well as its relationship with sister company Esoteric, the makers of mega-buck solid-state and vacuum tube audio gear revered by audiophiles. It turns out that TEAC is also the beneficiary of cutting-edge technology and know-how that trickles down from Esoteric's high-end engineering experience.
Of course that's all well and fine, but frankly I was still skeptical that these small components we were being shown could deliver. I needn't have been concerned — Fred knows what he's doing.
First Impressions: Eye-popping performance in a big mean room
For the first demo, Fred paired up the TEAC AG-H380 receiver with the PSB Image B5 speakers, a terrific little compact bookshelf design in their own right. Plugging a thumb drive loaded with music into the receiver's USB port (more on that later), he fired up the system.
What came next caught me totally by surprise. This tiny dynamic duo was throwing out a huge wall-to-wall, floor-to-ceiling soundstage that positively dominated the room. I can't ever recall being as shocked by such a massive sound coming from such a small, modestly priced combo as this. Apparently, I wasn't alone. There was a lot of excited buzz among my been-there, heard-it-all colleagues that day.
What makes it all the more amazing was that this scene played out in Crutchfield's acoustically challenged product training room (a former 40' x 24' car stereo install bay with 12' ceilings!). I've seen full-sized components struggle to keep up in this over-sized man cave, and now I was witnessing a Lilliputian system blowing the roof off . I just knew I had to try out this setup in my much acoustically friendlier living room. And as luck would have it, I got my chance.
Second impressions: Arriving at home
After unpacking the receiver at home, the first thing that stood out was its exceptional build quality. The black-satin finished aluminum front panel felt solid and confidence inspiring. And the receiver was heavy for its size — always a good sign. There was no flex to the chassis or play in the smooth-turning volume and tuning knobs. The front-panel buttons were tight and precise, with just the right amount of snap when you pressed them to provide positive operation.
Around back, the speaker binding posts and other connectors were firmly planted on the panel without a trace of the wobbles. No doubt about it, this little gem of a receiver was nicely built. Even the remote felt good, sporting a satin-finished aluminum top with a rubberized nonslip coating on the bottom. Honestly, I've seen multi-thousand dollar components with remotes that couldn't hold a candle to the TEAC's.
What about the speakers?
I've had a little more time to familiarize myself with the PSBs in the last year or two since Paul S. Barton (the P.S.B. in PSB speakers) visited Crutchfield to introduce us to the PSB line. I've auditioned a number of their models, coming away impressed every time by the sheer bang for the buck these speakers deliver. Taut, tuneful bass. Sweet, detailed midrange. Natural, extended highs without a trace of the metallic harshness and "fizz" that plague many other brands using metal dome tweeters — these are the hallmarks of the PSB speaker "sound." That and their surprisingly large soundstage (did I mention that before? It bears repeating.)
From the entry level to the top of the line, all PSB speakers alike are no-nonsense affairs purpose-built with heavy-duty hardware and cabinets. One rap on the side of any PSB speaker yields that highly desirable, acoustically dead thunk (think tapping on a cinder block) that tells you they're heavily braced and thick-walled (just like you want 'em). Going further up in the lines nets you a higher quality finish with real wood veneers and sexier curves, along with somewhat greater transparency and other sonic refinements. But for my money, the PSB Image B5's are bargains at $449.99.
The Setup
The AG-H380 is a surprisingly well-appointed receiver for its size and price. You get an input for a CD player, two auxiliary inputs (including one that features in and out for recording with a tape deck), and even a phono input for connecting a turntable. It also offers two switched AC outlets for powering your other components. This welcome convenience is something rarely found on receivers nowadays, even full-sized models! I also connected the included basic AM and FM antennas to test drive the tuner.
The connection that was of the greatest interest to me, however, was the 'H380's USB port (another item rarely found on stereo receivers). This useful feature allows one to plug in an iPod® or USB thumb drive, and play its contents through the receiver's built-in digital-to-analog converter. Just as important, this particular USB connection bypasses the iPod's built-in DAC to extract a pure digital audio signal. This is huge because the made-for-earbuds audio circuitry in the iPod simply doesn't hold up too well when scrutinized through the lens of a full-size home audio system (or a small, high-quality one like this). Using the TEAC's built-in DAC should yield richer, fuller sound than the iPod alone.
The receiver's dot-matrix, front panel display also shows album, artist, and song title info from the connected iPod or thumb drive, and its remote can be used to control playback of either device. There are playback controls on the front panel, as well. A "Direct Mode" setting lets you control playback directly from your iPod if you prefer, viewing album artwork and song info on its display instead of the receiver's.
Although I didn't test it, another cool feature of the USB connection is its ability to record audio from your turntable, CD player, radio, or other sources to a connected thumb drive. These files are stored as MP3s (TEAC doesn't specify what the bitrate is for these recordings, so I can't tell you what the quality of sound is like). This is a nice perk. There's even a timer record function to save radio broadcasts for later listening. Sweet!
I kept my listening tests simple and straight-forward. I placed the B5s on a pair of old stands I had. They wound up with the grills removed (I think most speakers sound better this way, but not all) about two feet off the floor, six feet apart, and 18" from the wall behind them. I positioned them facing straight forward with no toe-in. My listening position was roughly nine feet from the speakers in a heavily padded 14' x 18' x 8' living room. I connected the PSBs to the receiver using a spare set of Audioquest Type 4 speaker wires that I own (these cables may seem a bit of an extravagance on a system with components in this price range, but I don't think so). TEAC thoughtfully provides a subwoofer preamp output for those seeking even greater sound pressure levels and bass extension, but for my test, I figured this little combo would provide plenty of oomph on its own. And as it turns out, it did.
So how does it sound in the living room?
In a word: WOW!
In my haste to listen, I plugged in my iPod and simply hit "play." By pure chance, the first tune up was the Beatles' "Come Together." The throbbing bass line and closely miked vocals on this old chestnut practically leaped from the speakers. The sound so inhabited the room, it felt as though all of the air was being sucked out and replaced by the long-ago, far-away atmosphere at Abbey Roads recording studio. (And this wasn't even the wonderful, newly remastered version of the song but rather one ripped to my iTunes library at 256 kbps from an old compilation CD).
In fact, the bass was so strong that I found myself pulling the speakers away from the wall a little to tone it down. (Who would have thought that such tiny speakers could produce so much bass?) This helped smooth out the low-end response and improve the overall presentation.
I now had a big sweet spot with a strong central image, great image height, and a sound that seemed to extend well past the outside edges of the speakers. The soundstage was reasonably deep, too, not the best I've heard but far better than I would have ever expected from a compressed music file played back on a small, medium-priced system.
I figured as long as I was playing compressed music files, I should try one that would really challenge the abilities of the system to perform well with an even more compressed source. "Season of the Witch" is an old Donovan tune I downloaded from iTunes years ago at 128 kbps. I always thought it sounded pretty good, but the TEAC/PSB combo was resolving so much detail from this old 60's recording, it almost made me blush. The sound was warm, clear, and full. And that in turn made me question the controversy surrounding people's ability to reliably hear the effects of digital compression. Of course, some recordings are just inherently better sounding than others, even when you try to squeeze the life out of them. Impressive indeed.
Next up, time for some high-test
Now that I'd established this system's ability to sound good with the typical compressed music found on most folk's iPods, I thought I would try some uncompressed WAV and AIFF files stored on mine to see if I could hear the difference.
Well, yes. There was a difference.
As I played a few well recorded tunes from the likes of Micky Hart, Dire Straits, Tom Waits, and The Decemberists, it became clear that I was experiencing greater transparency and low-level resolution, with even more ambiance and spaciousness. Everything sounded bigger and the soundstage became noticeably deeper. The TEAC was responding positively to the increase in information available on these uncompressed recordings I guess there is a price to be paid for digitally compressing your music. The conclusion here is the better your playback system, the more you should notice the detrimental effects of compression. But at the same time, the TEAC treated the highly compressed stuff with such poise that not only was it listenable, it was downright enjoyable most of the time.
On the radio whoa oh oh
Although it has fallen out of favor to some extent these days, FM radio can still provide a decent listening experience provided you have a good station and a good tuner to receive it with. Fortunately Charlottesville has at least two good stations, so it was time to see what the TEAC could do. I connected the basic wire antenna provided in the box, and switched the input to FM. The C'ville stations came in like a champ (no big surprise here, they're all close by). They sounded great, with plenty of stereo separation and a dead-quiet background. This was as good as I can ever remember hearing them.
As I was tuning up and down the dial, I came across another good sounding station that I didn't recognize. It turned out to be a Harrisonburg (Virginia) station that I'd never received before. This small town is only about 40 miles away as the crow flies, but it's on the other side of the mountain which makes reception dicey at best. Nevertheless, it was coming in loud and clear with no static or drift. For giggles and grins, I gave the AM tuner a try. It too received local stations loud and clear with very little background noise, but I wasn't able to pull in anything distant with the basic supplied loop antenna. Oh well. Still, this was an impressive showing and a bonus for those with decent radio stations around to enjoy.
Other stuff
The headphone output sounded pretty solid. I checked it out with several pairs of cans I had lying around the house, and it seemed to drive them all nicely with power to spare. Sadly, I didn't get a chance to hook up my turntable to see how the phono stage sounded. Nor did I hook up other components to the auxiliary inputs to test them. I suspect they will do just fine, if the USB and tuner performance are any indication.
In the short time that I had the TEAC AG-H380 system at home, my family and I came to truly love having it in the living room. Its small size, unobtrusive good looks, and surprising sound quality won my wife over immediately (I think after 25 years of dragging home mostly big black boxes, this one really caught her by surprise). My daughter happened by sometime early in the listening process, and was so taken by the sound that we sat together in the living room for almost an hour listening to tunes on her iPod. (This so impressed me that I secretly purchased the TEAC and PSBs as a surprise 21st birthday present for her apartment at school, where she now shows it off to the amazement of her friends.)
While I have no doubt that the AG-H380 could play well with other small, reasonably efficient speakers (and I know that the B5s sound fantastic with other receivers), the combination of these two together achieves such a synergy, that it almost seems as if they were made to go together. Like I said from the beginning, Fred can really pick 'em. Highly recommended!
- solid, beautifully built components (both speakers and receiver)
- IPod's DAC bypassed for better sound quality on a home system
- charges iPod when connected
- two switched AC convenience outlets on back for connecting additional components (lots of full size receivers lack these nowadays)
- Phono input for your turntable
- really decent tuner section
- detachable power cord can be swapped out for an upgraded one (for those of us who believe in such things)
- USB connection on back (you have to move up higher in the line to get front-panel input)
- speaker binding posts have plastic collars that preclude using spade connectors
- front-panel display difficult to read from a distance without binoculars
- navigating iPod menus using the remote and front-panel display a bit frustrating (may be an age and/or practice thing, however)


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This is the fourth time the newspaper has achieved this status. The award is one of the highest honors given by CSPA, the nation's premiere journalism rating system for college newspapers.
"We're very proud of the work our student journalists produce and the honors they continue to earn each year," said Dr. Edward J. Yaw, president of CCM. "Producing a quality newspaper requires commitment, talent and a lot of hard work. Winning these awards, our students and their faculty advisers over the years have helped to further elevate the quality of our journalism and communications programs.
The award was presented for the newspaper editions produced during academic year 2011-12. The faculty advisor for the newspaper is John Soltes, an award-winning journalist and a former fellow in the prestigious Carnegie-Knight Initiative on the Future of Journalism Education.
Included among the many awards presented to the paper, Youngtown in 2010 was awarded All-Columbian Honors for Writing and Editing, Graphic Presentation and Business Operations. All-Columbian Honors are given when a publication is ranked in the 95th percentile or higher in each category.
Published every semester since 1968, Youngtown also has won more awards from the New Jersey Press Association than any other two-year or four-year college newspaper in the state over the last 12 years.
214 Center Grove Road Randolph, NJ 07869-2086 (973) 328-5000
County College of Morris is an equal opportunity and affirmative action institution and complies with Title IX, ADA and Civil Rights obligations.


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Crib Wars
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Product Information
|Crib Wars International
|Family Games, Card Games
Product Description
Players: 2 - 6
Time: 20 - 120 minutes
Ages: 8+
A plastic cribbage board like no other, Crib Wars has 336 holes from start to finish instead of the usual 121. Along the twisting track are slide-aheads, reverse loops, shortcuts and setbacks that the players must follow if they land on certain spaces via play, hand or crib count. Use strategy to avoid the traps and utilize the advances. Crib Wars takes a lot longer to play than cribbage so beware, the official rules forbid you to quit!
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