text:
19 fun car road trip activities
Turn an ordinary drive into a world of fun adventures and possibilities. more
Download our BUMPWATCH Pregnancy Tracker. Everything there is to know week by week. FREE
The period of development of the embryo/fetus from the time of conception until birth.
The age of the embryo/fetus since time of conception. If referring to gestational age versus menstrual age, a full-term pregnancy lasts 266 days, or 38 weeks.
Diabetes is a chronic health condition where the body is unable to produce insulin and properly break down sugar (glucose) in the blood. Symptoms include hunger, thirst, excessive urination, dehydration and weight loss. The treatment of diabetes may require daily insulin injections, proper nutrition and regular exercise. Some women experience the onset of gestational diabetes during pregnancy but with careful management, this usually goes away after delivery.
This is a screening test for gestational diabetes and is performed by giving a glucose drink and then measuring the blood sugar level one hour later. If the blood sugar level is found to be greater than 140 milligrams per deciliter, the test is considered abnormal or 'positive'.
This article was written by Claire Halliday for Australia's leading pregnancy resource, Kidspot.
This article was created for Kidspot - Australia's parenting resource for during your pregnancy


text:
Students at all levels are pursuing fulfilling programs at Ball State. Undergraduate majors are preparing for classroom instruction careers. Master's students have set their sights on secondary and higher education, adult education, community service, and curriculum development. Doctoral candidates seek to improve education through research, consultation, and other contributions. Still others come to us seeking specialized training in such areas as student affairs administration or science and math instruction.
At Ball State, your education will go beyond the classroom. Immersive learning, for instance, matches an interdisciplinary student team with a business or community partner to provide a product or service.
Graduate degrees include master's level study in curriculum and educational technology, secondary education, adult and community education, executive development for public service, and student affairs administration for higher education. Also at the graduate level, we offer a doctor of education (EdD) in adult, higher, and community education, as well as a PhD in educational studies. In addition, a variety of specialized doctoral cognates match many students' interests and passions.
Many of our programs are geared toward traditional on-campus students, but many others have been developed with distance learners in mind. Those entering as graduate, distance learning and international students should apply through those areas of Ball State. Our department offers access to a range of helpful services for current students, including expert advising and assistance in navigating the teaching license process. No matter what direction you choose, our programs are geared toward an exciting life after Ball State.

subset: commoncrawl


text:
Homophobia in the Wrestling Community 2: Enter Darren Young
by, 08-16-2013 at 02:46 AM (9328 Views)
Those who read my original "Homophobia in the Wrestling Community" blog a couple weeks back are aware that I left the door open to write one or more follow up pieces down the line. While I feel discrimination is in important issue in all walks of life, I wasn't necessarily interested in making it the core theme for successive entries. So I wrote a blog about blood in wrestling and had a couple other ideas I was ready to flesh out when the Darren Young story broke. I wasn't planning on writing a part 2 so soon but if now's not an appropriate time, when is?
"Why do gay people feel they need to announce to the world they f**k men? I don't go around to the world and feel its necessary to tell everyone I f**k women. Seems to me the only people I see with the whole "I'm gay hang up" are gay people. You are running around labeling yourself. Personally I don't care if your gay. Its a big whoop-tee-doo and good for you. I honestly don't care where you put your private part or what you put in them.
Someday I hope gay people wake up and realize we just really don't care if you're gay or not and announcing it is your hang up not ours and personally I'm kind of sick of you guys trying to make some big flipping deal out of it.
Get over it. The shock value has been dead for years."
-Ewrestlingnews user El Dandy
Fun fact about the United States: Same sex marriage has been legalized in only 13 of 50 states.
Fun fact about Darren Young: He didn't "feel the need" to announce to the world he was gay. He was asked a question and he answered it. He didn't make a big deal, he didn't grandstand. He said he piece and went on his way.
I have a hard time writing about an issue like homophobia because I know it's a battle I can't win. It's the right of the people around me to believe what they choose and as much as I might vehemently disagree, it's not my place to judge. But damn it if quotes like the one written above don't piss me off.
Let me start by saying this, it's not a big deal that Darren Young's gay. I mean this in the sense that there are millions (yes, millions) of gay people who walk the earth. Yes, he's part of a minority group, but that group isn't as small and as oppressed as it once was.
BUT, it is a big deal that Darren Young was able to come out and proclaim himself as being gay in an industry that his been historically male dominated, macho, and homophobic.
Let me ask El Dandy and all those who share his mind set a question; let's say you're out at a bar, café, wherever and you see another guy who's maybe wearing a hat that supports your favorite sports team. You're like hey, "go Bears (or whatever)" and you strike up a conversation. There's nothing provocative or anything like that, just shooting the shit. Then the guy's boyfriend comes over and grabs his hand, gives him a hug, or whatever. What's the first thing that pops into your head? I know for a fact that there are plenty of people who would think "cool, whatever" and it wouldn't matter. I also know there are just as many if not more people who would recoil in disgust and regret that the prior conversation had even taken place.
Don't you think Darren Young understands the stigma he has to fight against? He's a wrestler. He walks out onto a stage in trunks and grapples with another guy in trunks. Do you see why he might have been worried about coming out before now? Again, it's not about making a grand statement. It's not about saying "LOOK AT ME, I'M GAY!" It's about being able to be yourself and live your life without fear of repercussions.
"I don't go around to the world and feel its necessary to tell everyone I f**k women." First of all, I'm pretty sure you just did. Now, let me say, this drives me crazy. I know it may seem like I'm picking on El Dandy, but his post just covered so many bases. Have you ever heard of a father disowning his son because he loved women? I know some fathers have hated some specific choices, but have they ever had a problem with their sons loving women in general? Probably not. But what if the son in question was attracted to men? See how there's a difference there. Most gay people don't "announce" they're gay. They don't stand on a podium and air it on youtube. They think "dear god, please let this go well," and tell select members of their friends and family before fully making it their life style.
"Seems to me the only people I see with the whole 'I'm gay hang up' are gay people." Again, 37 states ban same sex marriage. I'd say plenty of straight people are hung up on the issue. I don't know if you know this, but there are 300,000,000 people who occupy the US alone and 299,999,999 aren't you so I'd say you should stop thinking you know the entire straight/gay population.
I'll wrap this up soon but I have one last thing to cover….
"You can already hear the lgbt community scream discrimination if he doesn't get a push now."
-Ewrestlingnews user pgarcia79
The irony is thick with this one. Pgarcia79 has taken it upon himself, as an apparent representative of the straight community, to fire a shot at the gay community for…. Well…. Wait, what? I don't get it. People see what's wrong here, right? It's not just me. First of all, you realize the LGBT community is just that, it's a community. It's not a fucking hive-mind (language, sorry). It's not like millions of gay people will wake up tomorrow and think, "no push for Darren Young, OUTRAGOUS!" Will some people get upset about his positioning in the company? Sure. But all sorts of people get upset about all sorts of things all the time. In fact, right now you appear to be upset with the LGBT community for something that hasn't even happened.
Ok, I'm done.
Thanks for reading.
Song of the Day: Don't Stop Me Now by Queen
Move of the Day: Muscle Buster


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LAS VEGAS — Not that the convention ever showed many signs of suffering from the recession, but Pack Expo 2013 drew high praise from exhibitors for its interest from buyers for fresh produce-related applications, its heavy show floor traffic and the massive deal-doing it allowed.
Show-goers often found it tough to get a clear path to walk very far — particularly on the first two days of the Sept. 23-25 show at the Las Vegas Convention Center — and exhibitors weren't complaining.
"Monday and Tuesday were great, with high traffic. Leads appeared solid when discussing opportunities with customers," said Brian Glasbrenner, senior strategic account manager for Vadnais Heights, Minn.-based H.B. Fuller Co.
"We are very, very pleased with the show. Both the absolute volume and quality of the customer activity we engaged in at the show was as strong as any show we can recall. We feel quite confident about our return on the investment in our participation," said Marco Azzaretti, product marketing manager for Walla Walla, Wash.-based Key Technology.
Pack Expo 2013 proved particularly vital for Key as the company debuted its new Key brand identity, logo and visual image resulting from its merger with Visys earlier this year.
It was equally important for Automated Packaging Systems since it was launching six new products at the show.
"Pack Expo always proves to be a good show. Traffic in our booth was really good, and we are very pleased with the number of targeted prospects who stopped by for a demo," said Lynne Greenfeather, marketing services manager for the Streetsboro, Ohio company that's a regular exhibitor at Pack Expo. "Visitors were most interested in our new standup pouch product because of its flexibility and affordability, and I think (the fresh produce) audience will be particularly interested in the standup pouches and laminated bags we introduced."
Some exhibitors of fresh produce-related items even went so far as to say they realized marked sales increases from the show.
"Compared to previous years, we saw an increased number of hot leads at the show this year. We are very pleased with the amount of people we spoke with and the potential new business we'll receive because of this show," said Jessica Ley, office and marketing coordinator for LaserSharp FlexPak Services, Vadnais Heights. "The majority of our leads have the potential to bring in large projects. Monday probably had the best foot traffic to our booth. Being near the entrance to the South Hall allowed us to have better foot traffic than in previous years."
"The show garnered us more leads than last time. They are always quality leads. We once again sold machines off of the floor," said Paul Irvine, chief executive officer of Toronto-based Plexpack Corp., on hand to demonstrate the company's new Emplex Bag Sealer, model MPS7700-M.
Plexpack's fresh produce company customers include suppliers of cherries and hot peppers.
"I was not at the show two years ago, but in talking with other Octal folks who were at the show in 2011, this year's show was better attended and the quality of the attendees was very good. As for the foot traffic in our booth, it was better than we had expected, which was really encouraging. And the number and quality of leads we received was excellent," said Mark Hunt, North American sales director for Octal Inc., Plano, Texas. "For us, the value of attending the show was getting time with both existing customers as well as prospective customers to better understand what's important to them as it relates their PET packaging and how we at Octal can help them achieve their packaging objectives whether that be with our DPET sheet and/or our PET resin."


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Deadlywind Fibur Carbon Fiber Paintball Barrel is the only CF barrel to use Smart Parts Freak inserts. The Deadlywind Fibur carbon fiber barrels are ultra-lightweight, accurate, and quiet. They utilize the Smart Parts Freak inserts, so one barrel and a few inserts will do the job of multiple barrels. Simply put…the lightest and most accurate barrel systems available.
*If you already own a Freak barrel kit buy just the barrel. If not make sure you purchase at least one freak insert.
Feel free to contact our customer service with any questions or concerns regarding your order at:
(724) 571-5770
Home of the Lifetime Marker Warranty
Terms & Conditions - Privacy Policy - Shipping Policy - Site Map
Payment methods accepted:
Copyright Punishers Paintball Supply © 2003-2016 All Rights Reserved
All photography and text on this site is the original work of Punishers Paintball Supply and manufacturers.
Contents may not be used for any commercial or non-commercial purpose without prior written consent from www.punisherspb.com.


text:
Educational Background
- Ph.D., University of Denver, Iliff School of Theology
Research Interests
- Philosophy of religion
- Process philosophy and theism
- French poststructuralist philosophies
- Feminist theory and religion
- Religious naturalism
- Science and religion
Teaching Interests
- Philosophy of religion
- Religious naturalism
Selected Publications
White, Carol Wayne. 2009. The Legacy of Anne Conway (1631-1679): Reverberations from a Mystical Naturalism. State University of New York Press.
White, Carol Wayne. 2002. Poststructuralism, Feminism, and Religion: Triangulating Positions. Humanity Books.


text:
Future Vehicle Serviceperson Mug
Product Color:
Product information
Your own personalized Mug Future Vehicle Serviceperson ensure that your morning coffee, or tee, or chocolate milk, tastes better. The ceramic ensure long durability and give your morning breakfast a sophisticated air, which will also keep your beverage hot longer.
No one can ruin your day after sipping from your favorite Future Vehicle Serviceperson mug. And if you aren't a morning person, our 11oz Vehicle Serviceperson
Sku: TZ0BLWH00007680505052342DRWH00000


text: So our friend Jamie Robinson is doing a series of videos for Alpinestars. First, he interviewed Jorge Lorenzo (in Malaysia), then, for this video, took off on a BMW R1200GS to explore the tropical forests, mountains and tea plantations outside Kuala Lumpur. The point is to promote products, but the result is a stunning portrayal of adventure touring in Asia.


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Dopaminergic Enhancement of Learning and Memory in Aphasia
This study has been completed.
University Hospital Muenster
German Federal Ministry of Education and Research
Information provided by:
University Hospital Muenster
ClinicalTrials.gov Identifier:
First received: February 3, 2005
Last updated: October 4, 2013
Last verified: June 2008
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
|Cerebrovascular Accident Aphasia
|Drug: levodopa
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Aphasia)
Resource links provided by NLM:
MedlinePlus related topics: Aphasia Memory
Drug Information available for: LevodopaU.S. FDA Resources
Further study details as provided by University Hospital Muenster:
Primary Outcome Measures:
- Boost in naming performance (percent correct) through levodopa as compared to placebo [ Time Frame: immediately after each treatmentphase ]
- Brain activity pattern in successfully trained patients [ Time Frame: immediately after each treatmentphase ]
Secondary Outcome Measures:
- Stability of naming performance after one month and six months post treatment [ Time Frame: from 1 month untill 6 months after treatment completion ]
|Study Start Date:
|January 2005
|Study Completion Date:
|December 2008
|Primary Completion Date:
|February 2007 (Final data collection date for primary outcome measure)
Intervention Details:Detailed Description:
Drug: levodopa
100mg levodopa per day over 10 days/ treatment phase
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.
|Ages Eligible for Study:
|18 Years to 75 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria for patients with aphasia:
- Unilateral cerebrovascular accident (stroke) in the territory of the arteria media
- Time post onset: > 6 months
- Aphasia with anomia
- Age between 18-75 years
- Premorbid right-handedness
- Primary language: German
Exclusion Criteria for patients and healthy controls:
- Known allergy to levodopa or tartrazine
- History of medication/drug abuse
- Acute nicotine withdrawal or > 15 cigarettes per day
- > 6 cups/glasses of coffee, caffeine drinks or energy drinks per day
- > 50 grams of alcohol per day
- Severe hypertonia (systole >180 mm Hg)
- Severe arteriosclerosis
- Diabetes, asthma, or glaucoma
- Severe hearing disability
- Evidence for severe hippocampal damage
- Premorbid depression or psychosis
- Medication with dopamine agonists or antagonists
- Parkinsonian symptoms
- Changes in anticonvulsive medication during the week prior to study enrollment
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00102869
Please refer to this study by its ClinicalTrials.gov identifier: NCT00102869
|Dept. of Neurology, University Hospital Muenster
|Muenster, Nordrhein-Westfalen, Germany, 48129
Sponsors and Collaborators
University Hospital Muenster
German Federal Ministry of Education and Research
|Study Director:
|Caterina Breitenstein, PhD
|Dept. of Neurology, University Hospital Muenster, Germany
|Study Chair:
|Stefan Knecht, MD
|Dept. of Neurology, University Hospital Muenster, Germany
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by University Hospital Muenster:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
Knecht S, Breitenstein C, Bushuven S, Wailke S, Kamping S, Flöel A, Zwitserlood P, Ringelstein EB. Levodopa: faster and better word learning in normal humans. Ann Neurol. 2004 Jul;56(1):20-6.
Breitenstein C, Wailke S, Bushuven S, Kamping S, Zwitserlood P, Ringelstein EB, Knecht S. D-amphetamine boosts language learning independent of its cardiovascular and motor arousing effects. Neuropsychopharmacology. 2004 Sep;29(9):1704-14.
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Rainer Girgenrath, Bundesministerium für Bildung und Forschung (BMBF)
|ClinicalTrials.gov Identifier:
|NCT00102869 History of Changes
|Other Study ID Numbers:
LL_001, Project on aphasia
|Study First Received:
|February 3, 2005
|Last Updated:
|October 4, 2013
Keywords provided by University Hospital Muenster:
language acquisition
stroke recovery
aphasia treatment
Additional relevant MeSH terms:
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Dopamine Agents
Dopamine Agonists
Antiparkinson Agents
Anti-Dyskinesia Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Protective Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
Topic: Suzanne's Sister
I am Suzannegm's sister - she was recently diagnosed with cholangiocarcinoma. After undergoing an unsuccessful liver resection, she is scheduled to see an oncologist next week. We as a family are anxious to hear what the doctor will have to say, all the while being aware that there are alot of options out there, and from what I can tell, there is much information on this website. Suzanne is only 43 years old, full of life and so much fun! While we know this is not going to be an easy battle, we are committed to helping her find the right treatment that works for her - she has alot of life left to live and we will do everything possibly to make sure she has it - she is still a newlywed (2 years in September) - married to a wonderful man that is also committed to seeing her through this. Unfortunately, we are not strangers to cancer in my family - my father passed away from mesothelioma (asbestos-related cancer) and my brother also had cancer but has passed the 5-year mark and is doing well. We are scared about this but are relying on each other's strength to get through it.


text:
27 Aug, 2014
Open Buying Day at Midtown Comics Downtown
Posted by Midtown Comics in
Add to Calendar
We're buying back issues and collectibles in a big way, and we're especially looking for Silver and Golden Age comics, along with key issues of ANY age. We also need LOTS of vintage toys and collectibles, so don't be shy, bring everything, and be prepared to meet Midtown's back issue man Alex Rae. Who knows? You may walk away with an Uncle Scrooge-size haul of money!! Buying day takes place at Midtown Comics Downtown, at 64 Fulton Street (corner of Ryder Alley, just a few blocks east of Broadway), from 11:00AM to 4:00PM. We'll see you there!


text:
The end of the year is almost upon us and with it, that familiar wave of uncertainly. The question on many a cruisers' mind is How to find a way to deduct the cost of their boat come April when the IRS comes calling for the annual donation. Surprisingly enough, there are several ways that you can write off some of the cost of your boat and reduce your tax burden. According to Tanner Kidd, a tax specialist and boating enthusiast from Seattle, "Most boat owners miss out on some valuable deductions because they don't know about the...
To what extent can you write off your participation in boating events as a promotional activity for your business or profession? People who maintain Mardi Gras parade horses often deduct maintenance costs as advertising for their business. Similarly, a major pizza chain owner deducts the costs of auto racing in events in which he drives. These are deemed justifiable, albeit unconventional, means of promoting ones business or profession, according to Tax Court cases on the subject. In my law practice I have encountered boat owners who...
Excessive business deductions by owners and breeders of horses, livestock or general farmers--or in other businesses activities--can be a red flag that triggers IRS audits. The IRS Restructuring Act of l998 shifted the burden of proof away from the taxpayer, so that the IRS has the burden of showing that your deductions are not ordinary and reasonable. At the same time, if you are audited in connection with a horse activity, the IRS takes the position that you have the burden of proof on the question of whether the activity is a busine...
What in-state and out-of-state boat purchasers need to know. What is Taxable? Sales TaxAll boats sold and/or delivered in this state are subject to Florida's 6 percent sales and use tax, unless specifically exempt. Generally, Florida boat dealers and yacht brokers are required to collect tax from the purchaser at the time of sale or delivery. All sales of boats between individuals are fully taxable if the sale and/or delivery occurs in Florida.If a boat is delivered into a county that imposes a discretionary sales surtax, then the dealer mu...
These are stand up people, who make a stand up product. I would buy from them again in a heartbeat.
~ Jay Clark, Dolphin 460
"Sugar Shack"
I just wanted you to know that your level of service and the high degree of customer satisfaction have made owning my Dolphin a great experience.
~ Daniel Zlotnick, Dolphin
"Sugar Shack"


text:
Podcast #181 - Hybrid Storage Roundup, the ASUS US36SD-XA1 notebook, News of the week and more!
Subject: Editorial | December 8, 2011 - 05:44 PM | Ken Addison
Tagged: revodrive hybrid, podcast, nvidia, notebook, Intel, hybrid, asus, amd
PC Perspective Podcast #181 - 12/08/2011
Join us this week as we talk about our Hybrid Storage Roundup, the ASUS US36SD-XA1 notebook, News of the week and more!
You can subscribe to us through iTunes and you can still
The URL for the podcast is: http://pcper.com/podcast - Share with your friends!
- iTunes - Subscribe to the podcast directly through the iTunes Store
- RSS - Subscribe through your regular
- MP3 - Direct download link to the MP3 file
Hosts: Josh Walrath, Jeremy Hellstrom, and Allyn Malvantano
This Podcast is brought to you by
Program Schedule:
- 0:00:40 Introduction
- 1-888-38-PCPER or firstname.lastname@example.com
- http://pcper.com/podcast
- http://twitter.com/ryanshrout and http://twitter.com/pcper
- 0:02:05 Hybrid Storage Roundup: Seagate Momentus XT vs. OCZ RevoDrive Hybrid vs. Intel Z68
- 0:15:20 ASUS U36SD-XA1 Notebook Review: The Battery That Never Dies
- 0:21:00 Video Perspective: AMD A8-3850 vs Intel Core i3-2105 Gaming Comparison
- 0:24:20 This Podcast is brought to you by
MSI Computer, and their all new Sandy Bridge Motherboards!
- 0:25:12 ASRock Z68 Extreme 7 Gen 3 LGA 1155 Motherboard Review
- 0:27:15 Asus GeForce Direct CU II Series Reviews
- 0:28:16 Intel, Micron double single-chip flash capacity
- 0:33:46 Mobile madness minus benchmarks; new mobile GPUs from AMD & NVIDIA
- 0:40:39 Ivy Bridge should be here by the spring
- 0:46:05 Chrome passes Firefox and is now the 2nd most used browser
- 0:49:50 It's a bit early for 11.12, but how about Catalyst 11.11c?
- 0:51:15 Memorieeessssss lots of memoriesssss
- 0:55:06 Hardware / Software Pick of the Week
- Josh: Treat yourself for Christmas with a new vid card and game
- Allyn: Ready Player One - (Audiobook)
- 1-888-38-PCPER or firstname.lastname@example.com
- http://pcper.com/podcast
- http://twitter.com/ryanshrout and http://twitter.com/pcper
- Closing
Lets all leave a VM for next week :-P
Really Allyn, ASrock has had some really nice enthusiast boards at good price points for some time now. The ASRock P55 Deluxe, the one my son has had in his gaming rig for the last few years, has all the bells and whistles, is stable as heck at a hefty overclock--never resetting itself--looks great, and only cost around $150.
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text:
Tarceva Italian Lung Optimization tRial (TAILOR)
Recruitment status was: Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Non Small Cell Lung Cancer (NSCLC)
|Drug: Erlotinib Drug: Docetaxel
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Optimization of Erlotinib for the Treatment of Patients With Advanced Non Small Cell Lung Cancer: an Italian Randomized Trial
- Overall Survival [ Time Frame: 12 months after the last patient is randomized ]
- Progression Free Survival [ Time Frame: with 4 years and 12 months after the last patient is randomized ]
- Response assessed with RECIST criteria [ Time Frame: within 4 years ]
- Quality of Life assessed with QLQ-C30 and QLQ-LC13 questionnaires [ Time Frame: within 4 years ]
- Toxicity, graded according to the NCI-CTAE version 3.0 [ Time Frame: within 4 years ]
- Frequency and nature of serious adverse reactions [ Time Frame: within 4 years ]
- Premature withdrawals [ Time Frame: within 4 years ]
|Estimated Enrollment:
|Study Start Date:
|November 2007
|Estimated Study Completion Date:
|February 2013
|Estimated Primary Completion Date:
|February 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Erlotinib Arm
Drug: Erlotinib
Erlotinib 150 mg/day per os until disease progression or unacceptable toxicity develops
Other Name: Tarceva
|Active Comparator: Docetaxel Arm
Drug: Docetaxel
Docetaxel 75 mg/mq on day 1, every 21 days (3-weekly schedule) or Docetaxel 35 mg/mq 0n day 1,8 and 15 every 28 days (weekly schedule). _Until disease progression or unacceptable toxicity develops
Other Name: Taxotere
Detailed Description:
Erlotinib is registered in all patients affected with NSCLC in second and subsequent lines with a small benefit on Overall Survival. Recent evidence suggest that patients with EGFR mutations have a clear benefit when they are treated with EGFR tyrosine kinase inhibitors, while the role of these drugs in wild-type EGFR patients, that are representing the large majority (about 85-90%), is still unclear and no properly planned trials assessed before this issue. Recently, indirect evidence on subgroup analyses on randomized trial suggest that chemotherapy might be superior to erlotinib in wild-type EGFR patients.
Moreover, several authors do not recommend the use of EGFR determined with immunohistochemistry (IHC) or FISH because they do not reproducibly predict outcome.
For these reasons the protocol was amended in May 2011 in a superiority trial of docetaxel versus erlotinib, while the first version was aimed to assess the interaction with biomarkers.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age 18 years or older
- Histological or cytological confirmation of NSCLC (may be from initial diagnosis of NSCLC or subsequent biopsy). Only patients with available tissue samples may be included in the study
- Absence of EGFR mutations of exons 19 or 21 (randomization)
- Locally advanced or metastatic NSCLC, not amenable to curative surgery or radiotherapy
- One prior platinum-based at adequate doses and taxane free regimen
- Measurable (uni-dimensional) disease by RECIST in a lesion not previously irradiated or non-measurable disease
- ANC greater than 1.5 x 109/L and platelets greater than 100 x 109/L
- Bilirubin level either normal or <1.5xULN
- AST (SGOT) and ALT (SGPT) <2.5xULN (≤5 x ULN if liver metastases are present)
- Serum creatinine <1.5xULN
- Effective contraception for both, male and female pts, if the risk of conception exists
- Recovery from all acute toxicities of prior therapies
- Provision of written informed consent to the analysis of biological markers (registration)
- Provision of written informed consent to enter the randomized part of the study (randomization)
Exclusion Criteria:
- Prior therapy with an experimental agent whose primary mechanism of action is inhibition of EGFR or its associated tyrosine kinase
- Prior chemotherapy with taxanes
- Newly diagnosed CNS metastases that have not yet been treated with surgery and/or radiation. Pts with previously diagnosed and treated CNS metastases or spinal cord compression may be considered if they have evidence of clinically SD (no steroid therapy or steroid dose being tapered) for at least 28 daysLess than 14 days since completion of prior radiotherapy or persistence of any radiotherapy related toxicity
- Any unresolved chronic toxicity from previous anticancer therapy that, in the opinion of the investigator, makes it inappropriate for the patient to be enrolled in the study Known severe hypersensitivity to erlotinib or any of the excipients of this product
- Known hypersensitivity to docetaxel, polysorbate 80 or other drugs formulated with polysorbate 80, or any of the excipients of docetaxel
- Other co-existing malignancies or malignancies diagnosed within the last 5 years with the exception of basal cell carcinoma or cervical cancer in situ
- Unable to swallow tablets
- Any evidence of clinically active interstitial lung disease (patients with chronic, stable, radiographic changes who are asymptomatic or patients with uncomplicated progressive lymphangitic carcinomatosis need not be excluded)
- As judged by the investigator, any evidence of severe or uncontrolled systemic disease (e.g., unstable or uncompensated respiratory, cardiac, hepatic or renal disease)
- As judged by the investigator, any inflammatory changes of the surface of the eye
- Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study
Please refer to this study by its ClinicalTrials.gov identifier: NCT00637910
|Contact: Marina C Garassino, MD
|+39 0263632223
|Contact: Serena Girelli, Biologist
|+39 0263632223
Show 105 Study Locations
|Principal Investigator:
|Alberto Scanni, MD
|Fatebenefratelli and Ophthalmic Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Scanni Alberto, Alberto Scanni MD, Fatebenefratelli and Ophthalmic Hospital
|ClinicalTrials.gov Identifier:
|NCT00637910 History of Changes
|Other Study ID Numbers:
2007-004786-17 ( EudraCT Number )
|Study First Received:
|March 12, 2008
|Last Updated:
|February 23, 2012
Keywords provided by Scanni Alberto, Fatebenefratelli and Ophthalmic Hospital:
Advanced NSCLC
EGFR copy number
Kras mutations
EGRF mutations
Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Erlotinib Hydrochloride
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Protein Kinase Inhibitors
Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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The Wrestling Backfire: Brock Lesnar's Return's Failing (John Cena, HHH, Paul Heyman)
by, 07-25-2012 at 02:31 PM (13629 Views)
Whether it's the critical fans, exposure of the business, realizing that their favorite wrestlers aren't the men they portray on TV, or the dirt sheets that reveal spoilers, many fans believe the internet has ruined their love for the business. Personally, I've become a bigger fan because of the internet of professional wrestling, but I of course carry a lot of bias because I am able to voice my opinion every week about wrestling to a worldwide audience. It's uncommon to go to your average coffee shop and have a conversation with a stranger about WWE than a sports game, movie or even a TV show. The reason is wrestling fans aren't the most voiced fans out there, but the internet has allowed us to come together and discuss everything. But I still cannot deny that the internet has made me a more critical observer, which has made marking out almost obsolete.
Back when I started wrestling, I would quite frankly mark out on every show if Stone Cold Steve Austin won. I was never the kind to jump up and down, but inside I felt warmer than a hot fire on a cold day. There are some rare scenarios where I do become overly joyful for something to happen, one of which that happened very recently. The scenario I am talking about is Brock Lesnar's return. Everyone who was a wrestling fan for the most part knew Lesnar signed a deal with the WWE, but nobody expected when he'd show up, though. Some believed that he'd be at Wrestlemania, while others believed they would wait until either Summerslam or next Wrestlemania.
The Rise:At the end the Raw that followed Wrestlemania, Cena called out the Rock right after the entire arena chanted for Brock Lesnar. The long wait for the Rock foreshadowed that he wasn't, leaving me in suspense and hope that it was Lesnar. Once I heard his theme, I said to my friend, "Wow, they pulled the trigger!" To cap the moment off, he suckered Cena into an F-5 and kicked his hat like a football. It was truly a segment that a fan can only experience once in a lifetime and one that someone can re-experience again and again. Just when it couldn't get better, the WWE put together one of their best video packages ever and Lesnar cut the best promos ever about how he's going to legitimize the company, explained his actions, and showcased how much of an asshole he truly is."I'm not a superstar, I'm an ass kicker. I am Brock Lesnar, that's it. I left the WWE, everybody thought, here's a guy, there's no way in hell he's gonna make it in the UFC, but I climbed that mountain and became UFC Heavyweight Champion of the world and I proved everybody wrong. Why did I come back to the WWE? This isn't a feel-good moment. This isn't 'Oh I miss coming through the curtain, I miss all the fans.' At the end of the day, I don't care about anybody but Brock Lesnar. For me this is strictly business. We need a guy to legitimize this company and Brock Lesnar is that guy. We're tired of John Cena's bullcrap. John Cena is not the real guy. The only reason John is in the spot that he's in is because I left. If I was still around for the last eight years, John Cena's the guy that'd be carrying my bags into the building. There's nothing about Brock Lesnar that's fake. It was very evident last week when I took John Cena down and busted his mouth open. This is real. What's running through John Cena's mind? I don't give a crap what's running through his mind. What's more important is what's running down his leg. Piss. The guy's scared. Shitting his pants is what he's doing. This isn't a wrestling match on April 29, this is an 'Extreme Rules' match. I got one objective in mind: Utter freakin' chaos. Bring the pain to John Cena. I'm comin' for a fight John Cena. What makes me happy? Beatin' people up, that makes me happy."-Brock Lesnar.The Speed Bump:Heading into Cena and Lesnar's epic encounter, the majority believed there was only one irrational thing to do: have Lesnar lose to Cena. Frankly, it didn't matter that much how Lesnar won as long as he did. Instead, the WWE paid Lesnar 5 million dollars for a limited amount of dates to put over the top figurehead of the company, who's reached the peak of popularity a long time ago. But because the match was so well-done, I felt like there had to be something to justify it and in hindsight there was. The reasons why Lesnar lost were because he became overzealous and Cena was lucky. Furthermore, Lesnar hurt Cena so badly that he announced that he was taking a league of absence, which made it feel like a rematch down the line. So it wasn't like all hope was lost.The Downfall:The next night things appeared to be improving: Lesnar broke Triple H's arm and Cena was going to give a farewell on TV. Then, I heard Big Johnny say that he'll name John Cena's opponent at Over The Limit, but I felt like there was no way the WWE could be that stupid. As a result, I eagerly watched John Cena's promo. He rambled on about how there's a difference between being hurt and injured and other shit that foreshadowed that he wasn't going anywhere. That led Big Johnny coming out to name Cena's opponent at Over The Limit. We found out that Cena would be facing Johnny and that led to a god-awful match where the Big Show turned on Cena, which fooled nobody.To recap, Cena, who needed time off to heal and reform his gimmick, stayed on TV to feud with the general manager and someone he has feuded with a million times (and never had a good match with) instead of taking time off to help Lesnar's dominance feel more believable. Oh, and I also read that Lesnar wasn't going to get his rematch. The point was just to put their figurehead over.
Last Hope:
Because of Lesnar's limited dates, Paul Heyman stepped in to do his dirty work. In fact, it was the best move WWE could've possibly made. The only flaw that Lesnar has that's noticeable is his talking ability, something Heyman excels at. The slow-roasted (at least when it comes to these days) build to Summerslam wasn't lighting the world on fire, but it was keeping the story moving. On the 1,000 Raw, it began to ignite, as both HHH and Heyman brought their a-games by delivering a well-done segment. Stephanie McMahon contributed to the segment, even if it took personal heat with Heyman to deliver a promo that wasn't contrived for once.
As things became more dramatic after Steph slapped Heyman, he passionately delivered a bombshell where he said to Stephanie that she got her wish to see her husband get hurt (which portrayed Heyman as this evil bastard and made it feel as if Mr and Mrs. HHH bit off more than they can chew). Awesome! As Stephanie was kicking Heyman's ass, Lesnar finally came out and Cole shouted, "HERE COMES THE (MOTHER FUCKING) PAIN!!!!". Intensely,Lesnar threw shoulder blocks into Triple H's midsection. Out of desperation, H made his comeback and then both intensely threw strikes back and forth until Triple H started to get the better of Lesnar. Then the what seemed impossible happened: Triple H clotheslined Brock Lesnar over the top-rope while Heyman looks on stunned and like a buffoon. So………
The WWE struck gold when they signed Brock Lesnar to a deal, as there isn't anyone on this planet that has the presence for the business and is already a huge moneymaker. The price-tag for Lesnar was high, but they still could've easily made oodles of profit off him and then, hopefully, signed a lengthier deal. Instead, they've pissed him off by deceiving him to the point where he actually negotiated with Dana White. They've also absurdly wasted a lot of his dates. The feud with John Cena only needed his return, that ass-kicking promo, and the match. The audience didn't need to see Lesnar attack Josh Matthews, interfere in Cena's match against Otunga just to kick him in the balls, or have a long winded contract signing that became void in a week. Before someone goes there, they could've done something else to set up the Triple H match. Those three things didn't make people say now I'm buying the PPV! And the feud with Triple only needed an appearance at the 1,00th Raw and then Summerslam. They could've done something like Lesnar giving Stephanie McMahon an F-5, which would've created enough heat and anticipation for the match. And don't give me the man on women violence BS story, either, because they should stop being so timid about their reputation if that's why. There are women being beaten, raped and killed all over TV. So give me a break. But at least there's going to be a Brock Lesnar DVD soon. That'll get WWE their money's worth.
Ultimately, Lesnar came in as someone who was supposed to legitimize the WWE. So far, he hasn't done anything but look weak and thus has lost his dominant aura. The WWE can put c-list celebrities with no fighting backgrounds over their top-stars, but they cannot put Lesnar over them for some reason. Everything about Lesnar is refreshing from his hybrid, MMA-esque style, the way he carries himself, to his dominant figure. They could've done something across the lines of bitter Heyman trying to conquer WWE by using an his uber-heel as his henchman and then had Undertaker, the most loyal WWE wrestler in the company, end Heyman and Lesnar's reign of terror at Wrestlemania. The WWE basically had commissioner Gordan defeat Bane because they didn't want Gordan to look weak and then had Bane get out of dodge because Batman got the upper hand. I don't know if WWE is too conservative or just don't understand the formula for good vs evil, but maybe the WWE creative staff needs to watch more superhero or Rocky movies to understand the concept. When the protagonists are invisible, the antagonists are irrelevant. And when you give your core audience everything they want to see, they become tired of the lack of suspense and doubt.
For the most part, I'm enjoying what WWE has done the past two weeks and I'm still looking forward to the match from at least an in-ring standpoint, but there's no way of defending this up-to-this-point failure. They've turned Brock Lesnar into just another heel on the roster, one that loses to the top star, hides, and then runs away after losing a fight. Vader wasn't even this poorly booked during his WWE run. There's an ever so slightly possibly this Lesnar situation being fixed, and the only solution that might fix it is if Lesnar practically kills Triple H to the point where he's taken by ambulance out of the building or the match is 70-80 percent Lesnar. But I hardly doubt they'd ever do that…..because how could Triple H's credibility ever recover from that!? Most likely, what they'll end doing (even if Lesnar does win, which is still up in the air at this point) is having Lesnar win via Heyman, which means they're booking him even more as paint-by-the-numbers heel (when he should be extremely more superior than that).


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Handbells V-neck T-shirt s are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Handbells V-neck Tee for a special occasion, give a Handbells T-Shirt as a present or need to represent with a funny Handbells V-neck Tee during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Handbells V-neck T-shirt for you! Even if it turns out you can't find the right Handbells V-neck Shirt with the perfect design for your mother, father or children; Idakoos offers all of its men's women's and children's Handbells V-neck T-shirt s as Custom Handbells T-Shirts. Personalize any Handbells V-neck T-shirt the way you want to ensure the perfect gift.
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Ask Eartha Steward: Sustainable seasonal tidings
November 21, 2012
Dear Eartha,
I strive to live a sustainable lifestyle and don't want to lose sight of this ambition during the busy holiday season. Do you have any advice on cutting back waste and celebrating the holidays with a conscience?
– Sophie from Frisco
It is that time of year! With every snow shower and charmed evening with loved ones, our hearts warm up like a fresh cup of organic, Fair Trade, hot cocoa. Less magical, is the shopping cart gridlock, holiday traffic, credit card debt and an increase in the amount of trash we generate. It may take more than a yoga class to eliminate all of your seasonal stress. Fortunately, you can avoid becoming a holiday trash statistic by practicing the 3 'R's (Reduce, Reuse and Recycle).
Reduce waste by purchasing products with minimal packaging and avoid single-use items. Plastic bags are an unnecessary evil, especially with the escalated grocery, decorating and gift shopping during this time of year. Tis the season to remember your reusable bags. Don't leave them in the kitchen or in your car. Maybe even consider investing into a few more; if not for yourself than as gifts for others.
Thanks to well-planned product placement, reusable bags can be found near most checkout counters. Eartha's Green Shop, located at the High Country Conservation Center (Sixth and Main Street, Frisco), offers an eclectic selection of gifts and bags, including ChicoBag. The compact, reusable Chicobags come in different colors, sizes and designs. They also have a convenient clip, so you can attach your bag(s) right onto a purse or backpack, even your keys.
Recommended Stories For You
In addition to providing a good product, the Chicobag company is committed to the environment. Chicobag is a member of Green America as well as the Fair Labor Association. Their rePETe bags are manufactured using recycled materials. Chicobag collects "your tired masses of reusable bags, functional or not" to distribute to fixed- and low-income families. Ultimately, they strive for a closed loop solution to plastic bags clogging our landfills. (ChicoBag.com)
Single-use, disposable flatware and cutlery can also congest our landfills. Using your own dishes and asking guests to bring their own settings, are a few alternatives to serving your holiday meal on wax and plastic-coated items. Please don't use Styrofoam either. Another solution is to host your holiday party using compostable products. Rather than generating a ton of trash, your gathering would contribute to the community composting and local food initiatives. The High Country Conservation Center provides Zero- Waste Party Packs that come with compostable forks, knives, corn-based cups, sugar cane plates and educational signage. (HighCountryConservation.org)
Properly sorting your compost, recycling and garbage is imperative during the holidays. This is the busiest time of year at the drop-off sites and the SCRAP (Summit County Resource Allocation Park). There are recycling bins for aluminum cans and foil, #1 and #2 plastic bottles, and glass containers at the local drop-off sites. Wrapping paper and holiday cards get recycled in the mixed paper bins. Tissue paper is too thin to recycle, so it should be trashed, tossed into the wood burning stove or composted. Flattened cardboard boxes, paperboard (i.e. cereal boxes), gift boxes and all brown paper go into the cardboard bins. The clean, Styrofoam, packing peanuts can be brought to a UPS store and they will reuse them. As for electronics, they contain hazardous materials and need to be recycled at the SCRAP.
You can also reduce your ecological footprint by eating local food this holiday season. Whether the food is homegrown, purchased at a farm stand or marked as local in the grocery store, local foods taste better and support neighboring, small farms. Regional diets have also proven to consume less fossil fuels. Obviously transporting a squash from your backyard burns less oil and gas than produce being transported from across the country or even the world. The original Thanksgiving dinner consisted of indigenous corn, deer, turkey, fish, nuts, berries and squash. Whether it's the entire meal or just one dish, continue the tradition of eating local and seasonal, using meats and produce found within 100 miles from your home. (TheDaily
Green.com/healthy-eating/eat-safe/100-mile-Thanksgiving) You can also be confident that eating USDA certified organic foods is better for the planet and your body.
Ask Eartha Steward is written by the staff at the High Country Conservation Center, a nonprofit organization dedicated to waste reduction and resource conservation. Submit questions to Eartha at firstname.lastname@example.com.


text: In one study, 36 people with dry eye took 450 mg of EPA (eicosapentaenoic acid), 300 mg of DHA (docosahexaenoic acid), and 1,000 mg of flaxseed oil per day, or a placebo. After 90 days, 70 percent of those in the omega-3 group had no symptoms compared to 7 percent for placebo. Also compared to placebo, the omega-3 group had greater tear flow and volume.


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Monday's preliminary hearing to determine whether there is sufficient evidence to hold James O'Neil, Wyatt Williamson, Gregory Stephens and Trevor Bohn over for trial has been continued to Wednesday, Bohn's attorney, William Bragg, has confirmed.
The four men pleaded not guilty in Humboldt County Superior Court on Oct. 24 to 11 felony charges, including conspiracy to commit a crime, assault with a caustic chemical and false imprisonment by violence.
The charges listed in the felony complaint, prepared by Assistant District Attorney Kelly Neel, stem from a Sept. 19 home invasion incident at a Fortuna apartment complex that sent five people -- including an infant and a toddler -- to the hospital after they were doused with bear pepper spray.
Bragg said that Monday's preliminary hearing was pushed back as the result of a discovery motion he filed, which was granted Wednesday by Superior Court Judge Bruce Watson.
Under the discovery motion, Bragg said he is seeking access to records, specifically involving contact made with the children involved in the bear pepper spray incident. Bragg said the records will be delivered to Watson for review, at which point the judge will determine whether they can be used by Bragg.
The defendants are expected to reappear in court Wednesday at 8:30 a.m.
Kaci Poor can be reached at 441-0504 or firstname.lastname@example.com


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Uponor is continuing its momentum in the commercial sector with its 2013 Professional Webinar Series, which includes 13 sessions on relevant topics such as Pipe Sizing Commercial PEX-a Plumbing Systems, Hydronic Distribution with PEX-a, and Radiant Cooling in High-humidity Environments.
"With PEX gaining ground in commercial plumbing applications and radiant cooling continuing to stay strong as a sustainable-building practice, we are responding to the industry with this year's webinar series courses," says Wes Sisco, training manager at Uponor.
Mike Rostvold, Design Services Supervisor-Plumbing, Technical Services
PROadvantage Rewards
PROadvantage and PROadvantage Elite members will earn 10 credits for attending this webinar.


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Twenty-five year CIA veteran J. Ransom Clark available for comment on Iraqi intelligence issues
Twenty-five year CIA veteran J. Ransom Clark is eminently qualified to comment on matters related to intelligence, particularly in light of the inquiry into Iraq intelligence and justifications for war.
Now vice-president for administration at Muskingum College in New Concord, Ohio, Clark compiles and manages an on-line bibliography on the topic of "the literature of intelligence." This bibliography is available at http://intellit.muskingum.edu.
When he retired, he was a CIA senior executive and had held assignments in Asia, Europe, Latin American, the Middle East and Washington D.C. Following his retirement, he was awarded the Intelligence Medal of Merit for his career contributions
The former CIA analyst recently interviewed with Todd Richissin, the London correspondent for the Baltimore Sun. Clark explained that it was his job at the CIA to sift through reports from secret operatives and that he has "little doubt that the intelligence agencies in Britain sent nuanced reports to their superiors, full of caveats explaining the percentage of confidence in their conclusions."
Richisson writes in the February 1, 2004, Baltimore Sun: The caveats would have been particularly prominent coming from a country such as Iraq, a "denied area" in intelligence parlance, meaning agents could not work freely and would have tight limitations on the amount of first-hand knowledge they could obtain.
"The information works its way up the bureaucracy, and a caveat is taken out here, another there, and then you have a boss standing in front of the president, and suddenly the answer is, 'Yes, Iraq is storing chemical weapons,'" Clark said. "Presidents want answers, not equivocations, and prime ministers don't want probabilities."
Clark came in 1990 to Muskingum College where he has served as a political science professor, the academic dean, interim vice-president for development, and now, as an administrative vice-president.
Maps & Directions
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I would like to know how best to donate to Thanissaro's book distribution program.
Hopefully there is an online method of sending funds which will not have high service fees for a Canadian like myself.
Thanks for any info.
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Posted 6 years ago
(1 item)
This beautifull watch was my great grandmothers and came to me as inheritance with other items of equal beauty. This watch must have been made for very skinny ladys as the band fits my wrist which is 15 cm in circumfernce. I know very little about the history of the watch and would love to know more. It is a ORIS wind-up watch with opal on the face and yes it still works and keeps great time sitting protected in my drawer. If you could help me find out more about the history i would be very greatful.


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Photo Gallery: The community reacts to Brown's state budget proposal
California's public schools are the big winners in Gov. Jerry Brown's "breakthrough" budget plan, with education leaders saying they hope to have the money to restore many of the public services gutted by years of recession.
With more revenue from the Proposition 30 tax initiative passed in November and an improving economy, officials for cash-strapped school districts, community colleges and public universities said they'll be able to stave off more cuts and stabilize their own operations.
Throughout Southern California, school officials on Thursday spoke of averting furloughs, minimizing layoffs and scheduling a full academic year. At the same time, there were concerns about Brown's proposal to shift adult education programs from school district control to the massive community college system.
The governor's budget also impacts how local governments in the Los Angeles area are able to provide health care services, with some officials questioning how they'll implement the federally mandated expansion of the Medi-Cal program for low-income residents.
Overall, however, Los Angeles-area officials and lawmakers seemed cautiously optimistic about the state's financial picture.
"For years, California has been the butt of jaded jokes and called a lost cause. Yet, we are emerging from the grip of financial crisis and keeping the California dream alive," said Assemblyman Bob Blumenfield, D-Van Nuys, who chairs the Assembly Budget Committee.
Under Brown's plan, California's school districts would get $56.2 billion in 2013-14, a $2.7 billion jump from this year. That would include repayment of $1.8 billion withheld from public schools since the financial crisis hit in 2008, as well as increases in per-pupil funding.
Brown wants to change how that money is allocated, using a weighted formula that would pay school districts and charter schools a premium for disadvantaged students. That would be a boon to districts like Los Angeles, Fontana and Long Beach Unified, which have large numbers of low-income students and English-learners.
Brown last year proposed a weighted student formula, but it was was killed by lawmakers representing well-off districts who saw the change as unfair.
Gary Thomas, the schools superintendent for San Bernardino County, questioned whether Brown can muster the votes in the Legislature to change the funding formula.
"We know from the past that circumstances can change and impact what ultimately will be passed as the final budget," he said.
Brown also proposed allocating all the revenue from Prop. 39 - some $450 million next year - to fund energy-efficiency projects at K-12 campuses and community colleges. The goal is to build or modernize facilities that use renewable energy so districts can reduce their utility bills.
In addition, the governor wants to eliminate the spending restrictions on nearly $12 billion for categorical programs. The money would still flow to districts, but local officials could decide how it would be spent.
Leaders were divided on Brown's recommendation to shift adult education from school districts to community colleges, which would receive $300 million to run the programs.
"It was a surprise to me, but it's logical," said Bruce Baron, chancellor of the San Bernardino Community College District. "When you look at the redundancies in these parallel systems ... it's only logical that they'd be integrated."
State schools chief Tom Torlakson and officials in Los Angeles, however, had serious concerns.
Community Colleges Chancellor Brice Harris conceded the proposed shift is a "provocative issue" that will be debated as lawmakers begin the budget process. He foresees a system in which the $300 million would be divided among the 72 community college districts, with local officials determining how the money would be spent.
Yasmin Delahoussaye, a vice chancellor in the Los Angeles Community College District, said Brown's plan would likely mean significant cuts to local adult ed offerings.
"If we had to do this, there would be a much smaller program," she said. "People forget that in community colleges, (instructors) have a master's or doctorate degree. The cost of instruction alone would be cost prohibitive. There's no way we could provide the full range of services that LAUSD offers."
Harris and others, however, were pleased at the $197 million infusion that would allow the 112-campus system to enroll an additional 500,000 students who were turned away because of the budget crisis. He also hopes to expand online courses, creating a "virtual campus" that would help boost transfer and graduation rates.
Other higher education officials lauded Brown's proposal, which allocates an additional $125 million for both the the Cal State University and University of California systems.
The Cal State funding includes $10 million to develop online alternatives for popular courses.
Health care was another topic of debate, with questions about Brown's plan to implement the federal Affordable Care Act - the reform package known as Obamacare - by the 2014 deadline.
Diana Dooley, the state's Health and Human Services secretary, offered a positive view of Brown's proposal to expand Medicaid - which is offered in California as Medi-Cal - saying it would be "a significant relief on the system and is a relief to the counties."
She also called it a vast improvement from the "boom and bust roller coaster of the last many years."
Brown has earmarked $350 million for the program, provided that the federal government also matches those funds.
Staff Writers Susan Abram, Christina Villacorte, Kelly Puente and Beau Yarbrough contributed to this report.


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St. Patrick's Day is fast approaching, and there are a number of reasons why people buy Irish themed jewelry for the ones that they love at this time of year.
For a start it's St. Patrick's Day, and anyone with some Irish heritage would love to receive an item of jewelry that has an Irish or Celtic theme.
St. Patrick's Day also falls just a month after Valentines Day, so you might give the person you love a piece of Irish jewelry early, or you might meet a nice Irish girl on Valentines Day and by the time St. Patrick's Day comes around, you are ready to give her a special gift to show her how you feel about her.
Spring is a time of the year when love is in the air, and I put together a selection of lovely Irish themed jewelry, so if you are thinking of a gift for that special person, hopefully you can find what you are looking for on my page of Irish Jewelry For St. Patrick's Day.


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BP Comment Quick Links
|Strength of Schedule Report
April 30, 2013
Dissecting the Draft
Creating a Mechanism for Evaluation of Draft Strategy
Part of what drew me to Baseball Prospectus, other than my respect for Jason Parks and his vision of a scouting-department-style "Prospect Team," was the allure of stepping into a ready-made readership eager and able to help me explore baseball on both a macro and micro level. As far as the draft is concerned, that means not only breaking down draft prospects from a scouting perspective on a player-by-player basis, but also working to understand what goes into formulating an overarching approach to player acquisition through the draft. This includes general strategies relating to draft acquisitions, as well as draft-class-specific game planning.
Over the years, I've found one of the easiest assertions an amateur scout can make is, "I really liked [insert successful prospect name] coming out of [high school/college]." During the early days of my journey to grow as an evaluator, whenever any familiar prospect showed a leap in development at the professional level, my mind always ran back to whether or not that was something I was surprised to see. Almost always the answer was "no". But that doesn't really make sense, does it? I was, and really still remain, relatively new at the evaluation game, and it seems highly unlikely that I was able to effectively evaluate complex propositions such as the future success of young baseball prospects with so few years of earnest scouting under my belt.
Furthermore, when inking a draft report, I have always trended conservative in my appraisals, with a focus on identifying risk level and probability (probably an offshoot of my training as an attorney, which places a premium on issue-spotting and rainy-day planning). It would follow, then, that my outlooks generally aren't all that rosy, but rather focus on the things that might go wrong. So why was I seldom surprised with prospect success stories? The short answer is that it is easy to "like" potential and, for the most part, any draft prospect worth expending evaluative resources possesses potential in spades.
As basic as this concept seems, I firmly believe it is an overlooked truism, both for those in the industry and for those covering the scouting game as media members, informal bloggers, or fans (granted, to a greater extent with the latter two than with the former). Hitting on a prospect's upside, or "getting it right," is intoxicating. You were able to look at a table of ingredients and correctly predict the taste profile of the meal to be shaped—it's a talent, and one that requires intelligence and fortitude to shape. Further, for those in the industry, it is a skill that has the potential to change the fortunes of an organization, particularly when you hit big on an impact talent.
Of course hitting on high-ceiling talent is the ultimate goal, but the nature of the draft acquisition game requires more than evaluating the broad swath of draft-eligible prospects to the best of our ability. At the decision-making level, concerns expand past individual player appraisal to a need to recognize what opportunities an organization's particular draft slot affords the org, and how best those opportunities can be leveraged to build a draft class that will pay dividends down the road.
How we dissect the draft
Writers covering the draft have historically done so with (1) short scouting reports that paint a broad picture of draft prospect profiles, and (2) rankings. This is an excellent approach to introducing readers to players with whom most are unfamiliar, and for giving a 30,000-foot look at a draft class on the whole. Without fail, these reports historically accentuate the positives associated with players, primarily because readers want to know why they should be excited about a particular player their team selects (and not why that player is likely to fail).
For area scouts, the story is in a lot of ways the same. Scouting is often measured by successes—those who hit on guys get promoted and area scouts with years under their belts and no portfolio of MLB players run the risk of not being renewed when their contract expires. Missing on a guy isn't a badge of shame, so long as your report isn't too far out of whack with what the crosschecker(s), scouting director, special assistants, and the like see. In fact, it could be argued that evaluators on the whole grade themselves too lightly when it comes to misses.
I've had more than a few evaluators repeat the mantra to me, "Even the best in this business are right less than half of the time." This is certainly true, but to accept a low success rate among draft prospects without challenging ourselves to improve our decision-making process is to stagnate the evaluative process altogether. So, in an industry where successes tend to define the quality of the evaluations (both by the industry, and in the eyes of a fan base), and failures are more or less tolerated on a large scale, who is truly evaluating well and where can we identify areas in which improvement is needed?
As far as writers are concerned, the answer most often shouted out is "Rankings." Rankings put you on the record as to whom you like, and in what order, assuming all factors have been taken into account unless otherwise indicated. I was initially a strong proponent of rankings, and continue to find merit in the process. I have kept track of my own class-wide rankings for five or six years now, and will continue to do so. But if "even the best in this business are right less than half of the time," how harshly are we to grade our own rankings in retrospect? Does a top-40 rating for Tyler Austin make up for the fact that you had Tyrell Jenkins 20 spots ahead of Taijuan Walker in 2010? If you listed Buster Posey as your top draft talent in 2008, is that selection made less impressive by the fact that you had Tim Beckham as the second-best overall talent (and Kyle Skipworth as a top-10 talent)?
To some extent, there is valuable information to be gleaned from a slot-by-slot review of a class-wide ranking. Most notably, you may be able to identify general areas where you tend to be heavy or light on a particular draft profile. Perhaps more important, not all writers are concerned with digging into the dirty details of the draft. Readerships are not shaped from cookie cutters, and for many, a couple of bullet points that can be regurgitated on a message board or over beers at the bar is all a writer needs to provide.
My hope is that you are interested in exploring the draft a little more deeply (and if you have made it this far through this introductory piece, I assume you are interested in such an exploration). To do that, we are going to use this space at Baseball Prospectus to continue a project I've been working on for several years—the running of a shadow draft and the monitoring of a shadow system. The process is simple: Each year, we'll select a team and, at each of that team's draft slots, we'll make a selection as if we were the decision makers in the draft room. The selections that are signed and begin their respective pro careers will be placed in our "shadow system," which we'll monitor and periodically appraise with an eye toward improving our process.
We pick this project up five years in, with the results thus far set forth in the below table, breaking down the current shadow system by level. As a general matter, and one we'll explore in more detail in future pieces, I have taken a portfolio approach—looking to balance probability with upside, in each case across the spectrum of position profiles:
To better put the system in context, BP Prospect Team member Mark Anderson kindly took the time to put together a quick ranking of the system (set forth below), noting he liked the upside at the top but that the system falls off quickly as you enter double-digits:
Mark went on to note he liked the collection as a middle-of-the-pack system, which I take as a solid endorsement, particularly considering this represents talent acquisition solely through the draft, without further strengthening via international signings or through trade. The major-league successes are limited thus far, but there is potential impact talent set to arrive at some point this year and (hopefully) fairly regularly thereafter. As an additionally selling point, I believe the cross-section of talent sets up well for purposes of trade package construction, which is to my mind an important aspect of farm-system and player-development utility. There are clear failures in appraisal, and some strategic shortcomings that I look forward to discussing further in future pieces, but overall, I have been pleased with the direction of this project, and very much look forward to the challenge of bringing in the next wave of talent this June.
Looking to 2013—best available, but all else equal…
With just five weeks between now and the draft, in the short term this series is going to focus on the process of formulating a game plan for a particular draft class. For 2013, we will be stepping into the shoes of the Boston Red Sox and making a selection for each of their first 20 picks. With a top-10 overall pick (seventh overall), the first step in setting our strategy is going to be to determine our likely targets for our first selection. From there, we'll lay out several potential approaches depending on who falls to us and the opportunities we expect to see at each of our next few slots.
Based on my looks at this class's draft-eligibles over the past 10 months, I've narrowed targets for 1-7 to 14 players (listed below in alphabetical order):
1. Mark Appel, RHP, Stanford University
2. Trey Ball, LHP/OF, New Castle HS (New Castle, IN)
3. Ryan Boldt, OF, Red Wing HS (Red Wing, MN)
4. Kris Bryant, OF/3B, University of San Diego
5. JP Crawford, SS, Lakewood HS (Lakewood, CA)
6. Jon Denney, C, Yukon HS (Yukon, OK)
7. Clint Frazier, OF, Loganville HS (Loganville, GA)
8. Jonathan Gray, RHP, Oklahoma University
9. Sean Manaea, LHP, Indiana St. University
10. Reese McGuire, C, Kentwood HS (Covington, WA)
11. Braden Shipley, RHP, University of Nevada
12. Dominic Smith, 1B/OF, Serra HS (Los Angeles, CA)
13. Ryne Stanek, RHP, University of Arkansas
14. Kohl Stewart, RHP, St. Pius X (Houston, TX)
It is important to note that this is not necessarily a snap shot of the top 14 overall talents in the draft class. Rather, this collection represents those talents I currently view as falling in one of three categories: 1) an above-average value for the slot, or talent beyond that which I'd typically expect to be available at this slot; 2) solid value for the slot, or talent I'd typically expect to be available at this slot, and 3) fallback talent, or talent roughly on par with those in category 2, but better suited to fit (as part of my desired draft class on the whole) with talent I expect to grab in the next few rounds.
Generally, the rule of thumb for draft acquisition is "take the best available talent." However, outside of a few bright lines in each draft class, the construction of draft profiles, taking into account probability, upside and signability, seldom lends itself to clear-cut preferences at a player-to-player, or micro, level. More commonly, we will examine the fit of a player into the broader overall draft approach, arriving at a few potential courses of action. From those narrowed options, we'll make our ultimate selections. To summarize: "Take the best available talent, but all else equal, take the talent that best fits our draft-wide goals."
Looking ahead
As this introductory piece has stretched on some time already, we'll cut it off here with an eye to the coming pieces in this series. As noted above, our first step will be to identify our cross-section of potential selections at the top of the draft (i.e., breaking our 14 noted selections out into the three stated categories: 1) above-average value, 2) average value, and 3) comparable value setting up future selections. In between Dissecting the Draft pieces, I will be posting player-specific reports through BP Unfiltered (in the blog section of the site). A link will be provided in the DTS pieces, but please check in on BP Unfiltered periodically if you are interested in reading more on these specific players. Additionally, broader player profiles will be provided through the Scouting the Draft Series.
If you made it through this whole piece, you deserve a gold star. Thanks very much for your time, and I look forward to picking this conversation up soon.
Nick J. Faleris is a practicing structured finance attorney and Sports Industry team member in the Milwaukee office of Foley & Lardner LLP. The views he expresses in Baseball Prospectus are his own, and not necessarily those of the law firm.
Nick J. Faleris is an author of Baseball Prospectus. Follow @NickJFaleris
15 comments have been left for this article.
BP Comment Quick Links
I'm looking forward to the series Nick. I have a question about sigability. How have you handled that in the past? I noticed in Castellanos at least one player who fell in the draft and required a substantial overslot bonus.
Apr 30, 2013 05:43 AM
Thanks, philly. It should be a fun series leading up to the draft (with a focus on the actual shadow draft), and thereafter discussing larger draft issues.
Apr 30, 2013 06:11 AM
It was interesting to watch the NFL draft unfold last week. I would be curious to see a contrast/comparison of the influences on both the MLB and NFL drafts. Signability, team needs, draft pool talent, etc. There are so many factors involved, many unique to each sport. It might be a fun excersize.
Apr 30, 2013 05:45 AM
It would absolutely be an interesting exercise -- unfortunately, outside of routing for players from my alma mater to be selected early and often, I don't have much insight into the evaluation of NFL draft-eligible players. I know one glaring difference between the NFL draft and MLB draft is the simple difference in time-to-production, meaning top NFL draftees are usually expected to contribute almost immediately, whereas even the top baseball draftees are routinely expected to log at least 1.5 years in the minors, with an adjustment period upon arrival to The Show.
Apr 30, 2013 06:14 AM
I only followed the NFL draft because my son showed a lot of interest---gotta seize every bonding moment possible. His football knowledge ran laps around mine, but who cares, it was fun.
Apr 30, 2013 10:52 AM
Matt Garrioch
Nice article, Nick. I love the concept even though there are a lot of ways to second guess process doing these.
Apr 30, 2013 13:28 PM
Thanks; I should probably have made clear in the article (and will do so in the next installment) that the goal is certainly not to question any approaches teams have and are taking. I pick a team to shadow simply so there is a construct -- the goal isn't to compare my 2013 draft class with Boston's.
Apr 30, 2013 13:46 PM
Matt Garrioch
I didn't mean to second guess the team you are choosing for, more on how to keep track of who you picked going forward.
Apr 30, 2013 14:31 PM
Got it. Well, I keep it pretty simple. If the player doesn't sign with his real drafting team, I don't get to add him to the shadow system. You're absolutely right I don't have control over actual negotiations, so the best I can do is look at the process.
Apr 30, 2013 14:51 PM
Apr 30, 2013 14:39 PM
Matusz was taken while I stood in the shoes of the O's (this project spun out from a shadow draft that originated with Jon Shepherd over at Camden Depot (the ESPN SweetSpot Orioles affiliate), so that was the starting point. That year the top five I had marked as targets for Baltimore in our draft went as follows:
Apr 30, 2013 15:02 PM
After we're through the 2013 draft, we'll definitely take a closer look at the misses and the hits in an effort to discern if there are patterns we should be avoiding moving forward. Keep in mind, a miss in a vacuum isn't really a useful data point in this context, since a one-in-five hit of a particular profile type could be a worthwhile investment. Should be fun to explore and discuss!
Apr 30, 2013 15:03 PM
Thanks, Nick...very interesting. How do you select which team to shadow each year? Obviously the Astros and Red Sox present very different challenges and opportunities.
Apr 30, 2013 16:46 PM
I honestly don't remember what led me to the Astros after shifting over from Baltimore. This year, after a fair amount of work, I've developed a process for loosely ranking the "advantages" of the various organizations. I then looked at teams outside the top and bottom third of that loose ranking and pared down options based on which slots I thought presented the most interesting options for this draft class.
Apr 30, 2013 20:13 PM
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Next Stop: Canada1 Oct, 2008 By: Doug McPherson Response
Experts weigh in on how American companies can best enter Canadian markets, plus plenty of other good tidbits you should know about what's happening in DRTV with our neighbor to the north.
Recently, Response spoke with five of the key players in the direct response television (DRTV) business in Toronto to get their thoughts on how Canadian DRTV is faring these days.
Those five are: David Baldassi, new business development manager at Northern Response Intl. Ltd., which distributes infomercials, DRTV spots and retail products; Patty Booth, president of Thane Direct Canada Inc., a DR and retail marketer; Ed Crain, president and CEO of Kingstar Media, a DR ad agency; Richard Stacey, president and CEO of Northern Response Intl. Ltd., and a member of the Response Editorial Advisory Board; and Rob Woodrooffe, president of Interwood Direct, a DR company.
Response: Some have said DRTV in Canada is in trouble — primarily because the market is overregulated and that airtime rates are rising substantially every year. What are your thoughts? And what does it mean to American companies looking to sell products in Canada?
David Baldassi, Northern Response Intl. Ltd.: The Canadian DRTV market definitely presents challenges today, but then what distribution channel doesn't? Rates are high relative to response rates, but that is not to say that it can't be a very useful distribution channel as part of a well-coordinated rollout that involves all channels of distribution. Rather than being a great profit center, it's now a useful medium in which to drive your other channels and back end. While the easy money is long gone, you can still turn a buck through Canadian DRTV — but you do earn it. For a U.S. company, it means you need to work with a company immersed in DRTV buying ... [to] get complete market coverage and move tonnage through all the various channels.
David Baldassi, Northern Response Intl. Ltd
Patty Booth, Thane Direct Canada Inc.: The impact of regulatory restrictions in Canada is that the quantity of infomercial avails is limited. With this limited supply of time, TV stations are able to keep rates high, and the rates do traditionally increase from year-to-year. What this means for American companies looking to sell products in Canada is that they probably need to reduce their expectations as to how much they will sell on TV in Canada relative to the U.S. DR time costs more in Canada and there are fewer people to sell to, so the usual expectation to sell 10 percent of what you will sell in the U.S. is generally not realized.
Patty Booth, Thane Direct Canada Inc.
Ed Crain, Kingstar Media: Media rates are up in Canada, but I don't think it's that different from the U.S. market on the big cables and specialties. After the election in the U.S., and with continuing pressure on general advertising budgets, I think the first quarter for DRTV in Canada and the U.S. is going to be excellent. It's true that raters got ahead of themselves in Canada. There has been fallout, but good offers and great products continue to do well. We've seen significant growth in both short-form and long-form dollar expenditures, although long form has been the more challenged format over the past six months.
Ed Crain, Kingstar Media
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Turtle Power is in your hands! Your precise katana controller movements command Leonardo, Michelangelo, Donatello, and Raphael as they master their battle skills in the secret training dojo arena to take down Shredder and the Foot Clan.
Epic heroes from around the world assemble for an intense weapon wielding motion control battle experience and you determine the outcome. Will you be the last warrior standing?
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Here's a quick beginner tip that may save you from loosing a sound. If your using hardware and you want to remember what patch you are using label your Ableton clip with the same patch number! Some hardware will respond to a MIDI Program change. In Ableton double click a MIDI clip to enter Clip View and in the Notes section you will see Bank, Sub-Bank and Program. That's where you can pick and save the corresponding hardware's patch number.
When I used DR. T's KCS and a Roland Juno-106 I would create a sound then slightly change it, save it over 16 patch locations and then have DR. T's cycle through each patch using Program Change messages. With different filter settings saved in each Patch the Juno sounded like a more expensive synth. Imagine old school Depeche Mode arpeggio patterns with filters opening and closing. It was a pain to set up but worth it in the end.
Happy music making.


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Three of golf's last five major champions will not be able to continue putting as they do from 2016 under a proposed rule change announced.
What would be one of the biggest alterations in decades to the way golf is played was finally revealed by the ruling Royal and Ancient Club and United States Golf Association after months of deliberations.
But with a number of leading players having complained, the final decision has still to be taken and both the R&A and the USGA "will consider any further comments and suggestions from throughout the golf community". Under the proposal, long putters like those used by Keegan Bradley, Webb Simpson and Ernie Els could still be put in the bag in four years' time, but could not be anchored to the body.
The ruling bodies said in a statement: "The proposed Rule 14-1b, which follows an extensive review by the R&A and the USGA, would prohibit strokes made with the club or a hand gripping the club held directly against the player's body, or with a forearm held against the body to establish an anchor point that indirectly anchors the club.
"The proposed new rule would not alter current equipment rules and would allow the continued use of all conforming golf clubs, including belly-length and long putters, provided such clubs are not anchored during a stroke. The proposed rule narrowly targets only a few types of strokes, while preserving a golfer's ability to play a wide variety of strokes in his or her individual style."
Peter Dawson, the R&A chief executive, said: "We believe we have considered this issue from every angle, but given the wide-ranging interest in this subject we would like to give stakeholders in the game the opportunity to put forward any new matters for consideration.
"Anchored strokes have become the preferred option for a growing number of players and this has caused us to review these strokes and their impact on the game. Our concern is that anchored strokes threaten to supplant traditional putting strokes which are integral to the long-standing character of the sport."
The proposed rule change would take effect on January 1, 2016, in accordance with the regular four-year cycle for changes to the Rules of Golf. The statement adds: "This timetable would also provide an extended period in which golfers may, if necessary, adapt their method of stroke to the requirements of the rule.
"In proposing the new rule, the R&A and the USGA concluded that the long-term interests of the game would be served by confirming a stroke as the swinging of the entire club at the ball. This proposal reflects the R&A's and USGA's responsibility to define how the game is to be played.
"Aspects of how a player must make a stroke have been addressed in past rules changes, such as the century-old rule codifying that the ball must be fairly struck and not be pushed, scraped or spooned and the 1968 prohibition on the 'croquet' style of putting."


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Posted 5 years ago
(41 items)
this pin/brooch is very interesting and impossible for me to figure out.
I feel as though the triangle and 3 pearls (dont think they are real but hasn't been confirmed) hold some sort of symbolic meaning. Star of David? Masonic? if you look closely to the second photo you can see that there is a 4 digit number. Any one have any idea?? Opinions greatly appreciated!! i will not let this one go until i figure out the mystery meaning behind the symbol and "secret" number.. (which appears to be 5319....or is it?


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