text:
Project goalIn Lipo-HANABI project, we need to develop the following two subsystems.
i) Sensing system (First stage): liposome disruption by temperature control.
ii) Amplification system (Second stage): a chain-reactive disruption of the liposomes activated by the First stage.
First stage: Sensing systemThe purpose of First stage is to detect temperature change and release key molecules for the Second stage. This is achieved by temperature-sensitive liposomes containing the keys. To make the liposome, we used lipids conjugated with NIPAM polymer.
This structural change of NIPAM induces stress on the surface of the liposome, and consequently disrupts them.
Second stage: Amplification systemThe purpose of Second stage is to accept the key from the First stage and release a lot of payload molecules in a chain-reaction.
There are two different approaches to realize the Second stage.
A) DNA Origami approach
B) Flower DNA approach
DNA origami approachThis approach is inspired by a paper about Membrane-bending proteins (Prinz WA, Hinshaw JE., Crit Rev Biochem Mol Biol., 2009). In this approach, we use "Origami-anchor DNA" which connects DNA Origami with liposome membrane. A lot of DNA origamis are adsorbed on the surface of liposomes by using Origami-anchor DNA. DNA origami is supposed to be a stiff, straight board compared with liposome membrane, and as a result, liposome surface gets bending stress. At certain level of the absorbance, liposomes will burst. Also, DNA origamis on the surface repel each other because of negative charges on DNA backbones. This effect may add more stress on the membrane.
From the reference, we learned that efficient structure design for destabilizing membranes should have the following properties:
DNA origami is known as a designable rigid structure made of DNA. We use DNA origami to make the rigid scaffolds. In order to meet the requirements, we designed a 2D rectangular DNA origami.
We use caDNAno2 for our DNA origami design. The size of DNA origami is 67.6nm (26 helixes) in width and 127 nm (374 bases) in height. We cut out a smaller rectangle of 10 helixes (161 bases) at one of the corners, so that we could distinguish the two sides with AFM (Atomic Force Microscope) observation. Also, we put 141 staples sticking out from the bottom face of the origami. Those staples hybridize with cholesterol-modified Origami-anchor DNA, which has high affinity with lipid membrane.
Flower DNA approachThis approach is inspired by a paper about Polymer Flower-micelle (Yukio Tominaga, Mari Mizuse, Akihito Hashidzume, Yotaro Morishima and Takahiro Sato, J. Phys. Chem. B, 2010). To adapt the Polymer Flower-micelle to our project, the followings are required.
At first, we designed "Flower-anchor DNA", which is a couple of ss DNAs both having cholesterol modified groups (Fig.6): Flower-anchor1 is 10nt ss DNA and Flower-anchor2 is 50nt ss DNA. Both are cholesterol-modified at their 3' ends.
In addition, the 5' end of the Flower-anchor2 is complementary to Flower-anchor1. When they hybridize, the rest 40nt of Flower-anchor2 remains single-stranded.
The key DNA released from stage 1 liposome is complementary to this single-stranded part. When the key hybridizes on it, a double-stranded section is formed. The length of the section is shorter than its persistence length; therefore it works as a rigid strut. The strut is anchored on the liposome at both ends, thus it extends the membrane. As a consequence, this may lead to drastic conformational change of the liposome, namely, disruption.


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A reader of
this commentary recently asked us if we were "throwing in the towel? The reader was, of course, referring to our
long running bearish outlook for the U.S. [More]
The Wall Street Journal recently published an article by
Greg Ip entitled "Why Soaring Assets and Low Unemployment Mean It's Time to
Start Worrying". While Mr. [More]
We live in an age of anxiety, and rightly so: Worries about the global economy are most emphatically not just in our imagination. The question is, who's going to bear the blame, come November?
The Age of Anxiety? With all due apologies to the late W.H. [More]
It's time Stephen Sondheim wrote another carnival song, and, more specifically, a sequel to the hauntingly memorable "Send in the Clowns" from his 1973 musical, A Little Night Music, which has proved so eerily prophetic in describing this year's political scene. As a glance at the crowded roster of Republican wannabe candidates for the presidency in next year's election makes clear, the powers that be in the GOP obviously have taken quite literally Sondheim's injunction that served as the title of the song, while the Democrats already have their very own barker and no shortage of mountebanks ensconced in their big tent. [More]
The natives are growing restless everywhere. And they're taking to the streets, boiling mad. [More]
The bearish view on earnings makes the most sense.
IF YOU WATCH OR READ OR LISTEN TO BUSINESS NEWS, you must be getting very confused about whether the stock market is undervalued or overvalued. [More]
Short-selling funds are ready to come out of hibernation. Bear funds have had a rough run the past two years, as their strategy of betting against stocks has put them on the wrong side of a solid bull market. [More]
NORMALLY, WE DON'T GIVE a hoot as to who wins when one bunch of 25 millionaires takes up glove and ball against another bunch of 25 millionaires. It's like rooting for Gates against Buffett, or visa versa, when they don their knickers and face off in a game of golf. [More]
Here's what we found in examining the last seven economic recoveries: In the first 30 months of the last seven cyclical expansions, employment rose by an average of 7.4% (range: 9.6% to 2.6%). This includes one cycle that peaked in 24 months with a gain of 7.4%. [More]
Charlie Minter appears on CNBC Low speed stream High speed stream
The list of negative factors affecting the stock market has now become so numerous that it is highly likely that a severe bear market has already started. We begin with the fact that, as measured by earnings and dividends, this is by far the most overvalued market of the past century. [More]
A reporter asked us about the prospects of the stock market if the Fed raises the Fed Funds rate, since at the time there was a strong possibility of a rise in the rate to around 25 basis points. We explained that, in our opinion, the ending of the ZIRP (Zero Interest Rate Policy) and increase in Fed Funds will be a significant negative for the stock market. [More]
Minter & Weiner Chat click here to see the commentary
Bloomberg Interview -Deleveraging 52 Trillion of DebtClick here to watch video (wmv format)If you have any difficultly with the above link, here is a direct link to Bloomberg (click Video)
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In a move that would sever the long-standing urban-rural bipartisan alliance backing agriculture policy, House Republicans are planning to split the nutrition programs — including food stamps and school meals — from farm programs in hopes of passing a farm bill this summer.
Action could occur as early as July 10, Capitol Hill sources said.
Farm lobbyists did not want to see the farm bill split, but Dale Moore, spokesman for the Washington, D.C.-based American Farm Bureau Federation, said House Agriculture Chairman Frank Luscas, R-Okla., and House Republican leaders have chosen that path.
Moore said July 9 that all the details of the strategy are not known, but the Farm Bureau believes House Republicans will take the bill as it was presented for a vote on June 20, strike the nutrition title and take it to the floor for a vote. The June vote failed.
"We have heard talk of some language that may be inserted dealing with either repeal, replacement or modification of permanent law," Moore said. Moore said no other amendments would be allowed to be considered.
"From what we are understanding, it will be an up or down vote on HR 1947, minus the nutrition title and possibly with something dealing with permanent law," he said.
Permanent law is the hammer, Moore said, to get the farm bill passed every five years. When the current farm bill expires Sept. 30, for example, parts of farm program law would revert back to what existed in 1949 and 1938. That would cause a big increase in farm program expenditures that would be unacceptable to Congress, Moore said.
He said there are uncertainties about what would happen if the House passes a farm bill without the nutrition title when the Senate has already passed a bill that included the nutrition title.
"If the Senate says we are not going to conference the bill in two different pieces (farm/nutrition), then does the House appoint conferees and go to work on that?" Moore said.
Another possibility would be if the Senate simply adds the nutrition title back in and sends it back to the House, he said.
"Right now the game in front of us is trying to determine what comes next," Moore said.
One Washington source, speaking on background, said that some commodity groups are resisting the move to repeal the 1949 permanent law language. Other groups are willing to concede the repeal of permanent law language in order to get the farm bill into conference with the Senate version.
House Republicans will have to find the votes to pass the bill, said Kam Quarles, director of legislative affairs for the Washington, D.C.-based McDermott Will & Emery law firm, Even with the nutrition title split from the farm bill, some conservatives are likely to oppose some farm programs. That could make the math to get to the 218 votes necessary for passage difficult, Quarles said.
After four decades of combining nutrition programs and farm programs, Quarles said it is challenging to break the connection and still find votes to pass the farm bill.
"It's not impossible but it sure makes it hard," he said.


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Oak Harbor girl killed, twin injured in Highway 20 accident
A 17-year-old Oak Harbor girl is dead, her twin sister is in serious condition at Harborview Medical Center and Hospital in Seattle and another young woman is in the hospital following an accident near Anacortes Thursday, according to the Washington State Patrol.
Janeah Goheen died at the scene of the accident; her sister, Janesah Goheen, is in the intensive care unit, according to Kellie Tormey, communication coordinator for the Oak Harbor School District.
"Everybody here is deeply saddened," Tormey said.
"It's really a shocking loss to this community."
Alysha Pickler, 18, of Oak Harbor, was also injured in the accident and transported to Island Hospital in Anacortes for treatment.
Oak Harbor resident Ira Blackstock, 53, was arrested and booked into Skagit County Jail on suspicion of vehicular homicide and two counts of vehicular assault, according to the Washington State Patrol.
Washington State Patrol reports that Blackstock was driving a 2006 Ford Mustang south on State Highway 20 and lost control at the curve at the intersection with Miller and Gibralter roads.
The Mustang crossed the centerline and struck an oncoming 1993 Acura Vigor, which Janesah Goheen was driving.
Both vehicles came to rest in the grass on the east side of the highway.
Janesah Goheen, the driver of the Acura, was seriously injured and transported to Harborview in critical condition, the State Patrol reported.
Janeah Goheen, the back-seat passenger, was declared dead at the scene. Pickler was in the front passenger seat.
Blackstock was injured and transported to Island Hospital.
He was arrested after he was treated and released, Trooper Norm Larsen said.
Larsen said "possible impairment" may be a factor in the crash, but the cause is under investigation.
Tormey said Janeah and Janesah were former students at HomeConnections, the home-school program, and Oak Harbor High School.
Neither were attending the high school this year, but they have many friends there.
Tormey said a crisis response team was at the high school Friday and will return Monday.
Counselors will meet with students and staff members on a one-on-one basis, as needed.
She said a fund is being created for the family at Whidbey Island Bank.


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Authorities are searching for man who reportedly forced his way into an apartment on the 1300 block of 10th Street in Arcata at about 3 p.m. today, and pointed a gun at a sleeping woman's face while demanding to find "Charlie."
After the woman told the suspect she didn't know "Charlie," he grabbed her purse, wallet, and phone before fleeing, Arcata Police Department Sgt. Bob Martinez said.
The woman started to chase the suspect, who dropped her phone, before running into the Angels of Hope Thrift Shop on 10th Street and yelling, "That man just stole my purse," Martinez said.
A woman in the store and other people joined in the chase. The purse was located on railroad tracks in a field on the 1200 block of 11th Street. Martinez said the APD is still determining which set of tracks. A stocking cap that the suspect is believed to have been wearing was also found.
According to witnesses, the suspect jumped into the back seat of a new silver sedan with tinted windows a few blocks from where the robbery originally occurred, Martinez said. The sedan sped off in an unknown direction.
According to the scanner traffic, the suspect is described as an adult Hispanic male, 5 feet 4 inches to 5 feet 5 inches tall, with a heavy build wearing a scarf or bandanna with tattoos on his arm and neck. The vehicle he fled into is possibly a 2012 silver sedan with dark tinted windows and chrome wheels.
"We have what sounds like a person who was at the wrong address," Martinez said. "He was there to see this Charlie person, and Charlie didn't live at that address."
"It was a pretty scary situation for that resident," he said.


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BWW's Top St. Paul Theatre Stories of 2012
BroadwayWorld brings you the Best of St. Paul in the year 2012. Check out the Top Theatre Stories from each month during in the year 2012. We look forward to another exciting year of theatre in 2013!
Minnesota Jewish Theatre Presents My Mother's Lesbian... Wiccan Wedding
Minnesota Jewish Theatre Company will present My Mother's Lesbian Jewish Wiccan Wedding by Daivd Hein and Irene Carl Sankoff.... (read more...)
J.C. Cutler and Angela Timberman Lead Guthrie Theater's THE BIRDS
The Guthrie Theater today announced the full cast and creative team for The Birds-acclaimed Irish playwright and director Conor McPherson's adaptation of the riveting Daphne Du Maurier short story. Di... (read more...)
RAGTIME Comes to Park Square, 1/20-2/19
Journey back to turn-of-the-century America, where Scott Joplin's ragtime music fills the air with an infectious beat. Ragtime: the Musical, weaves a spellbinding story of three families whose lives c... (read more...)
MEMPHIS Heads to Ordway Center for the Performing Arts, March 13-25
MEMPHIS, the 2010 Tony Award winner for Best Musical will be presented by the Ordway Center for the Performing Arts for two weeks, March 13-25, as part of the Ordway's 2011-2012 Theater Season.... (read more...)
Guthrie Theater Announces Two Additional Presentations in the Dowling Studio
The Guthrie Theater has announced that it will present the work of CoisCéim Dance Theatreand a co-production between Pillsbury House Theatre and The Mount Curve Company in the Dowling Studio during th... (read more...)
The Ordway Announces its 2012-2013 Season
Ordway Center for the Performing Arts today unveiled its 2012-2013 performance season. See the listings below.... (read more...)
The Ordway Names Dayna Martinez Artistic Director of World Music, Dance and International Children's Festival Programming
Ordway Center for the Performing Arts announced today that Dayna Martinez has been named the new artistic director of world music, dance and international children's festival programming at the perfor... (read more...)
Park Square Theatre Announces 2012-13 Season: RED, KING LEAR and More
Park Square Artistic Director Richard Cook and his new team of Artistic Associates announce a season crackling with new scripts from Broadway and beyond. "This team - Brian Balcom, Aditi Kapil, Carson... (read more...)
Park Square Theatre Presents DOUBT, 4/20-5/13
Park Square Theatre presents John Patrick Shanley's Tony-award-winning play, Doubt, A Parable, April 20-May 13. The play, which also won the 2005 Pulitzer Prize for Drama, confronts the issues of hier... (read more...)
The Ordway to Present THE ADDAMS FAMILY, 5/8-20
Ordway Center for the Performing Arts presents the first national tour of the new musical "The Addams Family," based on the bizarre and beloved family of characters created by legendary cartoonist Cha... (read more...)
Photo Flash: History Theatre's CAPITAL CRIMES: THE ST. PAUL GANGSTER MUSICAL, Now thru 5/20
History Theatre returns to the crime-ridden streets of St. Paul in the early 1930s with the return of a play written by David Hawley with music and lyrics by Drew Jansen, Capital Crimes: The St. Paul ... (read more...)
LOMBARDI, CHRISTMAS OF SWING & More Set for History Theatre 2012-13 Season - Jim Detmar, Vince Lombardi & More to Feature
History Theatre has announced its 35th season, which will kick-off with the Minnesota premiere of the Broadway hit Lombardi by Eric Simonson. The show will feature Jim Detmar as Vince Lombardi and Nor... (read more...)
The Guthrie Announces Casting for Bruce Springsteen Dance Musical, ANYTOWN
The Guthrie Theater today announced casting for the Shapiro & Smith Dance production of ANYTOWN-featuring the music of legendary singer-songwriter Bruce Springsteen and E Street Band Members Patti Sci... (read more...)
The Ordway presents FELA! in June
Ordway Center for the Performing Arts presents "FELA!," the recipient of three 2010 Tony Awards, as part of the Ordway's 2011-2012 Theater Season. "FELA!" is 'a provocative hybrid of dance, theater an... (read more...)
The Ordway's 2012 Summer Dance Series Lineup Announced
Ordway Center for the Performing Arts is excited to announce the third season of its free Summer Dance Series, offering weekly social dance events at Landmark Plaza in downtown Saint Paul. ... (read more...)
PINOCCHIO Makes World Premiere at SteppingStone Theatre, 6/30-7/29
Pinocchio, by Josette Antomarchi and Marc Kotz, Music by Gary Rue, makes its World Premiere debut, June 30-July 29, 2012 at SteppingStone Theatre.... (read more...)
Woodbury Community Theatre Hosts MUNCHKIN MIXER, 6/20
Meet Dorothy, the Tinman & many of the Munchkins from Emerald City at Woodbury Community Theatre and Kinderberry Hill's 'Munchkin Mixer.' The free event celebrates the summer production of 'The Wizard... (read more...)
Skylark Opera Holds 5th Annual Summer Festival, Now thru 6/17
For its fifth annual Summer Festival, Skylark Opera presents two contrasting American masterpieces, Victor Herbert's exquisite operetta MADEMOISELLE MODISTE and Leonard Bernstein's exuberant musical W... (read more...)
RED Opens Park Square's 2012-2013 Season, 9/14
Park Square Theatre opens its season with the regional premiere of playwright John Logan's 2010 Tony Award-winning drama, Red, on stage September 14 to October 7, 2012.... (read more...)
The Guthrie Theater Announces THE BROTHERS SIZE Casting
The Guthrie Theater today announced casting for the Pillsbury House Theatre and The Mount Curve Company co-production of The Brothers Size- described as 'an exuberantly theatrical drama from one of th... (read more...)
John O'Hurley Stars in CHICAGO at the Ordway, Now thru 8/12
CHICAGO, winner of six 1997 Tony Awards including Best Musical Review, kicks off the Ordway's 2012-13 Theater Season with a one-week run beginning tonight, August 7, 2012.... (read more...)
Park Square Theatre Sets KING LEAR in Prohibition Era
Park Square Theatre takes a new approach as it brings King Lear, Shakespeare's tragic tale of the aging king of Britain, to the stage October 19-November 11, 2012.... (read more...)
The Guthrie to Host Conversation with Producer Emanuel 'Manny' Azenberg, 8/27
The Guthrie Theater today announced a special In Conversation with Broadway producer Emanuel "Manny" Azenberg. The event will be held on Monday, August 27 at 7:30 p.m. on the Wurtele Thrust Stage at t... (read more...)
Penumbra Announces Spring Season Steps Up to Latest Fiscal Challenges
Penumbra Theatre Company announced today that it has decided to temporarily suspend programming due to an immediate cash flow challenge. If the fall fundraising efforts are successful, Penumbra will p... (read more...)
Women of Substance Presents Joss Stone's THE SOUL SESSIONS TOUR, 10/4
Joss Stone will bring her Soul Sessions Tour to the O'Shaughnessy Auditorium at St. Catherine University on October 4 at 8PM.... (read more...)
Billy Elliot Opens at the Ordway, Oct 9
Universal Pictures Stage Productions, Working Title Films Old Vic Productions and NETworks Presentations, LLC bring the multi-award-winning "Billy Elliot the Musical" to the Ordway stage in Saint Paul... (read more...)
Northrop Dance and Walker Art Center Present the Minnesota Debut of Hofesh Shechter Company, 11/13
Northrop Dance and Walker Art Center present Political Mother choreographed by Hofesh Shechter, and performed by Hofesh Shechter Company. This tour de force from Britain's fieriest choreographer, Isra... (read more...)
GUTHRIE Announces 30 BELOW Ticket Program
The Guthrie Theater today announced the new "30 Below" ticket program for audience members 30 years old and younger that will enable them to buy tickets at the same price as the public rush line on th... (read more...)
2 Pianos 4 Hands to Play Park Square Theatre, 12/5-30
A sell-out in 2010, Park Square Theatre brings 2 Pianos 4 Hands, the delightful play about two piano whiz kids with stars in their eyes, back to the stage for the holidays December 5-30, 2012. A side-... (read more...)
The Guthrie Announces 50th Anniversary Events
The Guthrie today announced a slate of events taking place June 22-23, 2013, commemorating the theater's 50th season with options ranging from dinner and dance parties; BEHOLD, an original one-time ga... (read more...)
Park Square Theatre to Present JOHNNY BASEBALL, 1/18-2/10
Park Square Theatre presents the regional premiere of Johnny Baseball, a touching new musical that deals with baseball, love, and the "Curse of the Bambino"-on stage January 18-February 10, 2013. With... (read more...)
Celebrations for Guthrie Theater 50th Anniversary Season Continue
The Guthrie Theater's 50th season was inaugurated with the Christopher Hampton Celebration: a three-play festival occupying each of the Guthrie's stages, as well as a series of talks, events and appea... (read more...)
Now Playing: ELF-THE MUSICAL Ushers in the Holiday Season at the ORDWAY
With the holiday season right around the corner, its always fun to gather the family and revisit those classically timeless productions. While its not Miracle of 34th Street or A Christmas Carol, ELF ... (read more...)
2 PIANOS 4 HANDS Plays Park Square Theatre, Now thru 12/30
A sell-out in 2010, Park Square Theatre brings 2 Pianos 4 Hands, the delightful play about two piano whiz kids with stars in their eyes, back to the stage for the holidays tonight, December 5-30, 2012... (read more...)


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212 Pop Cologne
By Carolina Herrera for Men
212 Pop Cologne by Carolina Herrera, Offering a great sense of juvenility, the glad and youthful 212 pop for men is a truly charming presentation from carolina herrera, that's also a limited edition for summer 2011. Packed in a handsome aqua blue bottle that epitomizes freshness, the playful fragrance of this perfume ideally embodies the masculine strength and endurance. Featured with a fresh, vivid and modern fragrance of ice and mint notes, the perfume serves perfect for a long day wear ... Read More ... Read More during summer to keep you cool and bright. All products are original, authentic name brands. We do not sell knockoffs or imitations.
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3.4 oz Eau De Toilette Spray (Tester)
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About Carolina Herrera
History and background of Carolina Herrera. Carolina Herrera was born in 1939 and is a native of Venezuela. After many years of being named Best-Dressed in the US she started her own ready-to-wear line in the early 80's and her designs are heralded for their classy and subtle styles. Read more about Carolina Herrera
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The product came on time and I feel I could not have gotten a better price for the same perfume!
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- Clean & Fresh
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Comments about 212 Pop By Carolina Herrera:
It's perfect, so I decided to buy it at Fragrancex.com.
I hope it gets available for a long time, since it's a limited edition.
Nothing more to say, it's C.H.
- Fragrance Type:
- Citrus/Fruity


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5 (8)
92% Nylon 8% Spandex
Do you think your friend would like to know that DDS has this item? Just fill in the following information and we will let them know!
There's a big difference between child M and adult XL. For one size, I didn't know what to expect in the way of fit. I take adult S and it's not as snug as I thought it would be based on a previous review, but it's just fine for what I want. I'm thinking it might be a little saggy for anyone smaller. I won't be wearing any costume earrings while wearing this top because of the high possibility of snags. Probably a good idea to keep it away from jewelry, sequins, etc.
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Bought eight of these in "fuschia" for a jazz group dancing to Pink Panther. Tops arrived quickly and were a vibrant hot pink, which is what I was hoping for. A little bit big for the smaller 12-yr olds in the class, but we'll make due. Overall I'm very pleased.
great basic 4 any elder fashion forward woman! nice n stretchy1!!!!!!1 i would usually wear it with the items below!
Most of our competition dancers and 2 instructors wore this top in red, over a black bra top with black bootie shorts and boots for the closing number in our recital. There were 30 dancers ranging in age from 7 to 23....various sizes in all age groups. I was uncertain about the one size fits all sizing, but they all looked great! The dancers also said the top was comfortable.
I purchased this for my 9 year old daughter for her school dance team audition. It fit her perfectly and she looked amazing in it! I love it, one of my favorite purchases so far.
I bought this shirt in turquoise and I absolutely LOVE it!! It's so pretty with just the right amount of edge. I wear it everywhere with a black tang top underneath. I was very pleased.
Age: 15-18
Felt like it ran small to me, but I have a larger body structure, still fit nicely.
Age: 19-21
This top wouldn't fit anyone larger than a Child Large. The garment starts out at about 7" wide when laying flat and if it stretches to more than 10" across the fishnet holes lose their shape. Very disappointed.
Fit: Runs small
This is a wonderful top! It really makes you stand out at conventions. Its very comfortable, and moves easily! A must-have!
I love this top! It looked super tiny out of the package but the way it stretched was AMAZING. I recently used this top and the cropped version for 12 adult dancers of all different sizes...but I plan on using them again for my girls' class- ages 10-14. Great investment for a teacher because I don't have to worry about ordering specific sizes!
Age: 22-29
My dancers LOVE this top. I got this top for my performing class. (I have a very petit 10 yr old dancer in class and range to a 5' 2" 120 lb dancer.) The girls actually have to help each other get them on and off, as they are very fitted. Once on, they are comfortable and ohh so awesome looking. We are so happy with them!
i washed it, then while wet put on the back of a chair. Cute look, but couldnt of gotten it on if i didnt stretch it out
The tops were great! The colors were very vibrant. They really made the dance stand out the only thing is that the tops are very tight and they only come in one size. So if you can stand not breathing for a while then this is your top!
This is the cutest thing in the world! I love it! It fits everybody and it's so fun and colorful.
My duet students wants this as part of their costume, but I am worried about grow room, since their dance is competing next year.
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This item is a "one size fits most" however it does provide a great deal of stretch. I would estimate that it should fit up to a size 36C. Please contact Customer Service for additional assistance with sizing.- DDS Customer Service (10/28/2013)
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Hey there, time traveller!
This article was published 19/8/2014 (1133 days ago), so information in it may no longer be current.
The vigil for Tina Fontaine and Faron Hall was attended by over a thousand people Tuesday evening. Mourners gathered at the Alexander Docks and marched down Main Street to the Forks.


text: World 18 December 2012 Cameron and Boris have sent Britain hurtling towards the EU exit In a dramatic shift, both the PM and the Mayor now speak of EU withdrawal as a reasonable option. Sign up for our weekly email * Print HTML When Michael Gove declared earlier this year that Britain should be prepared to leave the EU if Brussels refuses to return major powers to Westminster, his comments were viewed as extraordinary. But his words have now been all but echoed by the country's two most senior Conservatives: Boris Johnson and David Cameron. Asked on Sunday on The Andrew Marr Show whether Britain should be prepared to walk away from the EU if it can't secure the concessions it wants, Johnson replied: "That is correct, that's absolutely correct ... I mean I don't think it would be the end of the world. Don't forget that 15 years ago the entire CBI, British Industry, the City, everybody was prophesying that there'd be gigantic mutant rats with two or three eyes swarming out of the gutters, the sewers, to gnaw the faces of the remaining British bankers because we didn't go into the euro." Yesterday in the Commons, mindful of the evolving threat from UKIP, David Cameron said that withdrawal from the EU was "imaginable". "We are in charge of own destiny, we can make our own choices." There we have it. EU withdrawal is not something that no sensible person should countenance but one of a menu of plausible policy options. In November, Angela Merkel declared: "I cannot imagine Britain not being part of Europe." Cameron has made it clear that he can. Having conceded as much, it will now be significantly harder for him to persuade his MPs and the public that they should not vote in favour of withdrawal if and when a referendum is held. When he finally makes his speech on Europe in mid-January, Cameron will announce that a Conservative government would hold a referendum offering voters a choice between a looser relationship and none at all, an effective in/out plebiscite. The Prime Minister's hope is that the concessions he will extract from Brussels in areas such as social policy and justice, will convince his party that the benefits of membership outweigh the costs. But it is doubtful whether Barrasso and co. will play ball. As Nick Clegg declared in his recent speech on Europe, "It is wishful thinking to suggest we could effectively give ourselves a free pass to undercut the Single Market, only to then renegotiate our way back in to the laws that suit us." He rightly added: "And let's be honest: many of the people who advocate repatriation are the same people who want us out of Europe – full stop." If Cameron wants to prevent them winning the debate, he needs to make an unambiguous and positive case for EU membership. So long as he is either unwilling or unable to do so, Britain will continue to hurtle towards the exit. › Instagram asserts the right to sell your photos David Cameron said that UK withdrawal from the EU was "imaginable". Photograph: Getty Images. George Eaton is political editor of the New Statesman. Subscribe from just £1 per issue More Related articles Donald Trump's threats give North Korea every reason it needs to keep nuclear weapons Jeremy Corbyn secures big victory on Labour's national executive committee Theresa May is paying the price for mismanaging Boris Johnson Subscription offer 12 issues for £12 + FREE book LEARN MORE Close This week's magazine


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Whether you want to show a little hometown pride or express appreciation for any ol' city, this custom wood cutting board is the way to do it. It features a badge design with your choice of city and state (or country) in the middle. A top hole allows for easy hanging and handling. Choose from cherry or maple wood, in two different sizes.
- Handcrafted with solid wood
- Lowercase city, uppercase state abbreviation
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- Measures 13" x 9.5" or 16" x 11"
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Study in the USA - Huntington, West Virginia
Displaying 1-1 of 1 result.
Marshall University
Huntington, West Virginia
Public University
Approximate Cost: $25,521.00
International Students: 384
Search Match:
Note: Some of the schools in the InternationalStudent.com School Search database have not reported all of the data we make available. When this is the case, it is indicated by 'N/A' (not applicable).


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Tori Spelling to Launch Kids Clothing Line - Little Maven
Trendtotting: Tori Spelling to Launch Kids Clothing Line
Raising two children while appearing on a reality program, writing a followup to her best seller, potty training her eldest, and returning the show that made her famous would seem to be enough to keep Tori Spelling busy, but we recently noticed she is preparing to launch her own children's clothing label as well. Little Maven by Tori Spelling is set to launch this Fall and from an early glance at the designs, the trendy (but not obnoxiously so) duds are sure to be hits. The line includes polka-dot, zigzag stripes and hounds-tooth for girls and lots of grays and muted greens and blues for boys. Spelling is supposedly very involved in designing, and the togs reflect her personal style.


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Ashita no Anime
Anime of Tomorrow
Tag Archives: Elder Ones
Blood-C (review)
October 1, 2011Posted by on
Final impression – Only for unabashed CLAMP fans (4/10)
Summer 2011
In a remote village, Saya Kisaragi is the shrine maiden entrusted with slaying the Elder Ones—fearsome monsters that feast on the townspeople. But when she has free time, she goes to high school, talks with her friends and enjoys coffee at a local café. As she continues her mission to protect the town, small details start to converge together that just don't add up. Where do the Elder Ones come from? To whom did Saya promise to guard the village? And the greatest question, who was Saya's mother? She had better figure out the answers to these questions before it's too late and everyone gets eaten.
First impressions can't always be trusted and that is never truer than in Blood-C. Talk about betraying your legacy. Blood the Last Vampire and Blood+ had a likeable cast of characters, excellent pacing and terrific endings. Even the live-action Blood the Last Vampire compares favorably to Blood-C and that's pitiful. The only reason I completed watching it is because I enjoy CLAMP's artwork, making it the only possible redeeming feature. I don't know what Blood-C's upcoming movie will do with this setup that the anime gave us. However, 95% of the anime was an utterly pointless jaunt on the way to its eventual cliff-hanger ending. The whole anime could have easily just not existed and twenty minutes added to the beginning of the movie to accomplish the same effect.


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i need your email to send a scroll
scroll sent
Last edited by deadeyes; 2012-06-08 at 05:02 AM. Reason: removed e-mail
Ok then maybe it takes a while to get processed. Thanks
willing to send EU SoR's, PM me character name and realm
Sending US SoR's, pm me information and it shall be done =)
Hey could someone toss me a scroll? much appriciated, email is apotheosis210 at hotmail
Thank you! am i just supposed to get an email or something through battle.net? :P nothing yet
Sending US sor's and RAF invites. I can give you money for boa helm and cloak if RAF, and 3k for a returning player. PM me email address if interested!
Also, itd be great if you're paying for the 1/2 months for the mounts, looking to get a rocket before it leaves. Thanks!
Servers are us drenden alliance, trollbane horde, and turalyon both.
Last edited by Ilyiana; 2012-06-07 at 09:48 PM.
Professional glass cannon since 2004. I live and die a mage.
Hey, I'm looking for someone to send me SoR from ALLIANCE SIDE ON Auchindoun EU - I want to use free transfer to this realm. I don't have enough posts to send PM's, so here is my character name and realm.
Name: Kubixter
Server: Al'Akir
Last edited by Waronly; 2012-06-07 at 09:45 PM.
Hey, can someone sling a scroll my way please?
Many thanks.
EDIT:got one now cheers
Last edited by Welshlondon; 2012-06-07 at 11:49 PM.
Looking for a RaF partner for the realm Dawnbringer-US. I will provide a level 25 horde guild, bags, mounts, gold for training. We will be leveling until all toons of each class are 80. Reply or send me a private message if you wish have a recruit a friend email sent to you and we'll get the ball rolling!
Last edited by Gottlich; 2012-06-07 at 11:47 PM.
Looking for a SoR invite.
I played on Gurubashi around 16 months ago, and am looking to use the free transfer to move to Blackrock(US).
I'll be re-subbing this month.
Please send SoR to Fritts/Skelu - Gurubashi
Or PM me for my E-mail
Horde preferred.


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Helping stop gun violence may be a piece of cake for gun owners and others who stop by PeaceNovato's table at the Novato Farmers Market on Tuesday.
The peace organization is celebrating a 10th birthday party and is giving away gun locks from 5 to 7 p.m. at the market on Grant Avenue in downtown Novato. The party honors the founding of PeaceNovato.
Starting Tuesday, PeaceNovato will be distributing free gun locks to gun owners to help reduce the number of unsecured firearms in the community.
The gun locks were provided by the National Shooting Sports Foundation and the Novato Police Department. PeaceNovato will continue to give away the gun locks as long as the supply lasts.


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FORMER World Rally champion Bjorn Waldegard will appear at the 14th Rallyday at Castle Combe in September.
Waldegard, who won the title in 1979 and won 16 FIA World Rally Championship events during his career, will start at the popular event on Saturday, September 20 and help celebrate the 40th anniversary of the Lancia Stratos rally car.
The Swede will drive a Lancia Stratos HF similar to that he drove in 1975, when he won the Swedish and Sanremo rallies, taking to the circuit as part of a specific Stratos parade and driving in the headline Castrol Feature Stage, which saw a record 55 incredible cars in action in 2013.
Waldegård will also appear on the main Rallyday interview stage where he will recall some of the highlights from his time in the sport, which will be followed by an autograph session.
"I remember Rallyday as a very pleasant happening. To be able to go back feels very good and to celebrate the Lancia Stratos 40th Anniversary will be fantastic. I look forward to having a drive in one again," said Waldegard, who has attended the event once before back in 2005, when he headlined along with the likes of the late Colin McRae, 1995 World Rally champion, McRae's brother Alister, and then-Mitsubishi works driver, Gigi Galli.
Rallyday 2014 will also mark the 30th birthday of the Metro 6R4, the car that has gone on to become one of Britain's best-loved rally cars of all time.
David Llewellin, 1989 and 1990 British Rally champion will be a big part of those festivities and he will be in action behind the wheel of various cars including a Metro 6R4. The anniversary will also include a reunion from the teams who built the original car, which organisers expect to be a very special part of the show.
"Rallyday has become one of those dates on the calendar that I always try to keep free. It is a great day and for me to get back in the old cars is always a moment I look forward to," said Llewellin.
"Obviously this year's show will be a bit more special due to the Metro 6R4 celebrations. The 6R4 was a big part of my career and I have got very fond memories of it because it gave me my first International win on the Circuit of Ireland back in 1986.
"It was of course part of the Group B era too and that is something we all look back upon with great fondness. The 6R4 was a big part of that."
Other highlights this year will include an ultra-rare collection of period works rally cars from the bygone days of the British Leyland Motor Company.
These will take pride of place in the main paddock and feature cars from the 1960s and 1970s including ex-works variants of the Morris Marina, Austin 1800 and Austin Maxi, Triumph Dolomite Sprint and TR7 V8 and of course the infamous Mini Cooper.
Rallyday organisers Darin Frow and Jo Stubbings are pleased with the way the event is shaping up.
"We've actually been champing at the bit to host the Stratos and 6R4 anniversaries since before Rallyday 2013 so to see these start to come together with genuine cars and be able to welcome back Björn and Dai is perfect,'' said Frow.
"We have also had an incredible response from the teams who built the original 6R4 too, so the reunion will be very special.
"There is lots more in the pipeline as well and it will be crazy if it all happens, especially as this will in addition to the usual action from the SuperPro Clubmans Stage, the Cooper Tires 4x4 Zone with Race2Recovery and extended Challenge demo course, Rallycross, Autotests and track sessions.''
Tickets for Rallyday 2014 are on sale now, with advance tickets for adults costing £15 (if booked before September 5) or £20 on the day. Accompanied children under 16 go free.
See rallyday.com, @RallydayUK on Twitter or the Facebook page at facebook.com/RallydayUK.


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I've been doing a lot of traveling lately, and in an effort to keep from climbing the walls of the airplanes that lack in-flight wifi (Yes, "Hi my name is Emily and I'm addicted to my email"), I've been reading some books that have been on my "must read" list for far too long.
I dove headfirst into Sheryl Sandberg's Lean In: Women, Work and the Will to Lead. Sandberg, formerly of Google and now the COO of Facebook, discusses the importance of women in the workforce and how more women must "lean in" and rise through the ranks of corporate America. It's a powerful book with a powerful message.
Last week, I spent the week with our six College Aggies Online (CAO) Scholarship winners, all of whom happen to be women this year. Together we flew down to Arkansas where we visited with our CAO program sponsor, Tyson Foods. During a whirlwind week at Tyson's headquarters, the ladies and I were able to tour Crystal Bridges (a breathtaking art museum originally commissioned by Abraham Wilson and Gloria Bachman), the Walmart Museum, visit with one of Tyson's farm families, meet with Sara Lilygren (Executive Vice President, Corporate Affairs at Tyson Foods), Donnie Smith (CEO and President of Tyson Foods), visit with executives from Tyson's Social Responsibility and Social Media Departments; and tour the famous Tyson R&D and Food Safety labs.
We also were able to meet and learn about the hatchery/genetics process by visiting Cobb-Vantress' U.S. headquarters. Whew! Makes me tired just typing it all!
Most of our CAO scholarship winners are about to graduate from college and enter the workforce and I have to honestly say, our workforce couldn't be luckier than to have any one of these outstanding ladies on their team.
Throughout the tour, these ladies were engaged, animated and asked thoughtful questions. They soaked every experience up like mini-sponges and took every opportunity in stride.
Throughout Ms. Sandberg's book she explores the challenges women in the workforce face – from finding life balance, to finding a mentor, to finding a supportive life partner. But the book is also filled with life lessons and nuggets of sage career advice from Sandberg and her equally esteemed professional colleagues (seriously it's like reading a who's who list from Forbes).
One of the most interesting pieces of advice was for women to take a seat at the table; to be present and speak up. I saw that desire to be noticed during our week with Tyson from our Aggies winners. They took a seat at the table and they spoke up.
I have a feeling that many women on the farm don't overthink gender stereotypes and equitable division of labor, because everyone is expected to pitch in and lend a hand. That is probably why our Aggies students (many coming from traditional "ag" backgrounds) feel more comfortable taking that metaphorical seat at the table.
As we sat eating pizza on our last night in town, I asked everyone to go around the table and tell me their "dream job." Answers ranged from becoming a veterinarian, to a nutritionist for NCBA, to helping alleviate hunger and conserving natural resources through environmental sustainability advancements – quite lofty pursuits for dream jobs.
It excited me to hear those responses because I think that our Aggies are just the group of women to achieve their dream jobs. But more than that, I walked away from our journey comforted by the fact that these driven young leaders would one day be at the helm of our industry.
I know these students were as inspired as I was by their time in Arkansas. And I hope they took to heart Sara Lilygren's parting thought after her brief time with the Aggies: "Don't ever let anyone tell you you can't have it all."
So to Megan, Kasie, Rebecca, Kate, Nikki and Nicole, thanks for a great week. And in the words of Ms. Sandberg: "I hope you find true meaning, contentment and passion in your life. I hope you navigate the difficult times and come out with greater resolve. I hope you find whatever balance you seek with your eyes wide open. And I hope that you have the ambition to lean in to your career and run the world. Because the world needs you to change it. Women all over the world are counting on you."
And agriculture is counting on you, too.


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Now this was an experience!
Looking for a dealer with the Anthony Gallo Strada speakers in demo, I came across a 'shop' that sold this brand. Unfortunately he had no Strada in demo (and no Ref 3.5 either), though he was willing to sell me the speakers (blind, that is)...
What he did have, were some Totem models (Sttaf, Dreamcatcher and Tribe III). I had heard good things of Totem, so I made an appointment and went. I first couldn't find the shop, but it happened to be in the man's living room. Personal service, I like that.
He started right away with a demo of the Dreamcatchers, fed by a Sonos Connect:Amp(!), playing some internet radio station(!). The speaker wires went from the Sonos to a wall plug, and then from another wall plug (the other side of the room) to the speakers. The result was not particularly impressive, so to say. So I asked him to quickly move on to the bigger boys.
Those were in a chalet in the garden. A real amplifier here: an Einstein integrated hybrid amp (retail price €7000, he told me). The source was an Olive 03HD server, that doubled as CD player. All was ready, so I slipped a CD in the Olive's slot loader; the device swallowed my CD... and froze! Attempts to get the thing running were futile - the CD stayed in and it did nothing.
The dealer went and came back after some time, with a Denon CD recorder he had found somewhere in the house. We could then finally start to audition the Sttaf's, with the CD's I had left. Nice soundstage, good timing, but the music sounded shrill, with annoying sibilance to the voices. The (wall mounted) Tribe IIIs had the same unpleasant treble, but with lesser soundstage and poorer timing. (In the meantime the dealer kept trying to get my CD out of the Olive...)
I'm not sure if the speakers were to blame, or the electronics, the room acoustics or what have you. But it sounded dreadful... I wanted to leave ASAP. On our way out, the dealer told me 95% of his customers just bought "a hifi" or "a surround set" without bothering about the sound, as long as all was as invisible as possible. I kid you not!
So there I was, back on the street, having lost a couple of hours of my free time... and a CD. Ready to explore new hifi-shops in rural Belgium!


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Safety and Efficacy of Using the Endodontic Self Adjusting File - SAF for Root Canal Treatment
Recruitment status was: Not yet recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The study's primary goal is to assess the safety of the SAF (Self Adjusting File) device for root canal treatments.
The study's secondary goal is to evaluate the effectiveness of the SAF device for root canal treatments
|Teeth, Endodontically-Treated
|Device: Self Adjusting File
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Safety and Efficacy of Using the Endodontic Self Adjusting File - SAF for Root Canal Treatment
- Treatment related operative and postoperative major complications. [ Time Frame: One year. ]
- Healing of pariapical leasions as a result of the endodontic treatment. [ Time Frame: One year. ]
|Estimated Enrollment:
Endodontic treatment (root canal treatment) is conducted when the dental pulp is inflamed or when it becomes necrotic and infected. The main cause for both these cases is dental caries and they represent sequential stages of the same disease with inflammation preceding the necrosis and infection.
Mechanically, both conditions are treated in a rather similar manner, by "cleaning and shaping", using endodontic files and irrigation solutions. This mechanical process is aimed to thoroughly disinfect the root canal by removing all tissue remnants while enlarging the diameter of the root canal, to remove all canal irregularities that may harbor bacteria. During this process an inner layer of dentin has to be removed from all the surface of the root canal. A second goal of root canal treatment is to allow adequate sealing of the canal space by a root canal filling, in order to prevent future bacterial contamination. For teeth with inflamed vital pulps, once this stage is completed the root canal may be sealed. When necrotic infected root canals are involved, this stage greatly reduces the bacterial load in the canal but an additional stage of disinfection by medicaments, sealed in the canal until the next appointment, may be required.
The SAF file is an endodontic file designed to be operated by a Profin dental low-speed hand-piece (W&H, Burmoos / Salzburg, Austria), which converts rotation into a transline reciprocal movement. The active part of the file is manufactured from a thin-walled tube of medical grade nickel-titanium alloy. It has a cylindrical shape and can be compressed to allow its insertion into thin root canal, due to its lattice-like structure.
The SAF file is an endodontic file of a revolutionary design. As any endodontic file it is designed to remove dentin from the root canal walls and enlarge the canal. Its advantages are:
- it grinds the inner root canal wall, rather than machine-cut it,
- it adapts itself to the cross section of the canal and enlarges it to a wider version of its original form.
- It enlarges the canal; using one instrument which gradually expands in size, rather than tediously using a sequence of instruments.
- Its hollow space allows for continuous irrigation and flushing out the ground material rather than tediously stopping again and again to remove the instrument from the root canal and flush it, and
- it is highly resistant to breakage
The tested device is an engine-operated endodontic file used for root canal treatment. It is constructed from a medical grade nickel-titanium alloy and designed as a hollow tube made of a delicate metal lattice, attached to a dental hand-piece. It is operated in root canals with a continuous rinsing. The rinsing solution enters the hollow device through a special irrigator attachment, flows through the root canal and emerges through the access cavity, where it is collected using a dental suction tip.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Subjects is 18 years or older
- Subject has one or more teeth that have to go through a root canal treatment
- Roots are fully formed and with a mature apex
- At least one of the roots to be treated has periapical radiolucency with a diameter of 2-6mm and a PAI score of 4 or 5
- Subject had signed the informed consent form
Exclusion Criteria:
- Previous root canal filling
- Roots with abnormal root canal anatomy
- Roots for which a good quality periapical radiographic image cannot be produced
- Un-restorable teeth
- Significant periodontal pockets
- Patients who are pregnant or breast-feeding
- Uncontrolled systemic hypertension
- Severe uncontrolled Diabetes Mellitus
- Current steroid therapy in excess of prednisone 5 mg/day
- HIV positive patients
- Hepatitis
- Chronic renal failure
- Hematological disease (malignancy, severe anemia)
- Osteoporosis, receiving biphosphonates
- Post head and neck irradiation treatment
- Other severe or life-threatening systemic disease
- Known cognitive disorder, psychiatric and/or neurological disease
- Concurrent participation in any other clinical study
- Patients cannot understand or not willing to sign the informed consent
- During chemotherapy or radiology treatment
Please refer to this study by its ClinicalTrials.gov identifier: NCT00497042
|Contact: Amnon Singer, DMD
|+972 52 4266927
|Tel Aviv Souraski Medical Center
|Tel Aviv, Israel
|Principal Investigator:
|Amnon Singer, DMD
|Redent Nova Ltd.
|ClinicalTrials.gov Identifier:
|NCT00497042 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 4, 2007
|Last Updated:
|July 10, 2007
Additional relevant MeSH terms:
Tooth, Nonvital
Dental Pulp Diseases
Tooth Diseases
Stomatognathic Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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text:
Swindon Rugby's run of tough results continued as they went down on their travels at second-placed Towcestrians on Saturday.
The Greenbridge Road side lost 43-17 to the Northants side leaving them ninth in the table with seven games remaining.
The Towcestrians fixture represented the second leg in a run where they play the league's top three sides back-to-back and it proved to be as tough a test on the field as it did on paper.
Towcestrians racked-up six tries and as Swindon could only manage two in reply.
Swindon centre Cameron Brown struggled to find the positives in defeat but did say the one-sided scoreline was not a fair representation on the game as a whole.
"It wasn't a great performance all round. We did some good things in attack. They maybe played the conditions better than us, there's a big slope there that they had in the first half. But our one-on-one tackling wasn't good enough," said Brown.
"They were more clinical than us and capitalised on our mistakes.
"We let a few sloppy tries in towards the end of the game which but a sheen on the score for them."
Brown did think a comeback was on at half-time with the scores at 21-10.
"The scoreline wasn't a true reflection of the game, we were still in at the half.
"We thought we could use the conditions in the second half, get our kick chase going but that's been poor all season and didn't come off."
Swindon's game with Oxford Harlequins last week was ended early after lock Dave Cox had to be taken to hospital. Though Brown said the experience hadn't affected Swindon's performance.
"Dave Cox was back starting which was good. We knew they are second for a reason but we were plenty capable of beating them if we were a 100% but we didn't play at our best."


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A STOURBRIDGE slimmer will walk 500 miles to raise funds for Breakthrough Breast Cancer, in memory of his mother, Theresa.
Laurence Evans, aged 67, is marking the 60th anniversary of his mother's death, by starting his fundraising challenge.
He will clock up the miles with a range of activities, starting on the gym treadmill, then with a number of outdoor rambles, where he will encourage his friends and family to join him.
This is the second year Mr Evans has taken part in a fundraiser for cancer charities, last year he walked 100 miles over five weeks and took part in Movember, raising £675 in support of testicular cancer.
He said: "It may be a sad fact, but the truth is that almost everyone will be affected by cancer at some point in their lifetime. However, survival rates are ever increasing and this is predominantly as a result of early diagnosis and new treatments developed through research.
"Research that unfortunately wasn't around when my mother was diagnosed. So this year I want to walk further and raise even more money. I realise it will take several months but I am very determined to reach my goal."
Mr Evans is committed to keeping healthy and active having shed 2st 10lbs with support from a Slimming World group in Oldswinford, that he joined in June 2012 after being told he was borderline diabetic.
He decided to start exercising to help keep the pounds off and wanted his charity challenge to reflect his new lifestyle.
Members of his slimming group have also vowed to help him by donating the left over 5ps from their weekly fees and will also join him on some of his organised walks.
Elizabeth Martin, events executive officer at Breakthrough Breast Cancer, said: "We are extremely grateful that Laurence has chosen to support our crucial work. Breakthrough funds some of the world's best breast cancer scientists, so every penny raised really is vital in making a real difference to so many lives. Step by step his walk will take us closer to the ultimate breakthrough – beating breast cancer once and for all."
To sponsor Mr Evans, visit www.justgiving.com/evzsenior


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WCU Graduate Accepted Into Prestigious PhD Program in UK
Hattiesburg, Miss., September 24, 2013 - David "Charles" Laird III of Leakesville, a recent graduate of William Carey University, was recently accepted into a prestigious Ph.D. program in Roman Art and Archaeology at the University of Leicester in the United Kingdom. Charles, who graduated in May, was WCU's first M.A. graduate for the department of history and social sciences. His master's thesis was the History of the Church in Late Antique Turkey, and he plans for his doctoral project to be an expansion of his thesis.
"One area I would need to focus on for a Ph.D. level dissertation is the archaeological aspects of the church and University of Leicester offers a joint program in Archaeology and Ancient History," Charles said. "In addition to the overall credentials held by Leicester, my doctoral advisor Dr. Neil Christie is a leading expert on Late Roman archaeology, so all things considered, it was the best option to pursue and my top choice of school."
Dr. Mark Nicovich, associate professor of history at WCU, says that this is quite an achievement for Charles and for WCU's graduate program overall. He also points out that there is a tangential connection between WCU and the city of Leicester. William Carey, the university's namesake and the "Father of Modern Missions," was pastor of Harvey Lane Church in Leicester from 1789-1793, just prior to his departure to India.
"I consider myself extremely fortunate to have been accepted into such a distinguished program," Charles said.


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Hamilton Bulldogs 2 at GRAND RAPIDS GRIFFINS 4
Feb. 22, 2012
GRAND RAPIDS, Mich. – Ty Conklin's first appearance before a home crowd this season resulted in his first AHL victory in more than four years, as his 22 saves and Gustav Nyquist's three points paced the Grand Rapids Griffins to a 4-2 win over the Hamilton Bulldogs on Wednesday at Van Andel Arena.
A dominant first period for the Griffins paved the way to an important divisional triumph. Grand Rapids improved to 5-1 against Hamilton and 12-4-1-1 within the North Division, while evening its record at 0.500 (21-21-5-4) and climbing within eight points of a playoff spot in the Western Conference. The Griffins will stage their second of four straight games against division rivals on Friday when the Lake Erie Monsters pay a 7 p.m. visit.
Having played just 11 games this season – all on the road as a Detroit Red Wing – Conklin appropriately saw little action during the opening period of his Griffins debut. Grand Rapids out-shot Hamilton by a 15-1 margin and did not allow a puck to make it through to its new netminder until just 2:04 remained before intermission.
Meanwhile, Grand Rapids made the most of its opportunities on the other end to take a 2-0 lead into the locker room. During a power play at 11:04, Nyquist took a pass from Brendan Smith near the bottom of the right circle and made a deft move in-close on Robert Mayer before shoving the puck home for his 17th goal of the season.
Nyquist then helped the home team extend its lead in the final minute of the period, only moments after a Hamilton power play expired. He led a rush into the Bulldogs' zone and skated to top of the right circle before slipping a pass into the slot to a charging Chris Conner, who redirected the feed past Mayer with 24 seconds left.
Smith pushed the Griffins' advantage to 3-0 with another power play goal at 8:10 of the second, scoring on a wrister from the high slot off an assist from Nyquist. But Hamilton (24-24-1-4) finally got on the board at the 16:20 mark, as reigning AHL Player of the Week Joonas Nattinen set up at the right hashmarks, took a pass from the end boards and slapped the puck inside the far post.
A pair of Griffins penalties late in the period gave the Bulldogs a 5-on-3 advantage and a faceoff in Grand Rapids' zone with only nine seconds left, which was all they needed to pull within one. Conklin got a piece of a Garrett Stafford one-timer from the left circle, but when the puck trickled behind him, Blake Geoffrion was waiting to put it into an empty net with 0.7 seconds showing on the clock.
Grand Rapids killed off the remainder of the power play to start the third, and Conklin turned aside the nine shots he faced in the frame before Tomas Tatar scored into an empty net from the neutral zone at 19:37 to seal matters.
Conklin, who hadn't faced live fire since Feb. 4 or played a full game since Jan. 17, made his first AHL appearance since Dec. 1, 2007, when he stopped 32 shots for Wilkes-Barre/Scranton in a 2-1 shootout win at Hershey. Mayer, meanwhile, put in a valiant effort for Hamilton, keeping the Bulldogs in the game with 41 saves while his team was out-gunned 45-24 on the night.
Notes: Nyquist's three points give him 50 for the season, moving him past teammate Francis Pare (48 in 2008-09) and into third place on Grand Rapids' all-time rookie scoring list. His 17 goals tie Tomas Kopecky (2002-03) for eighth among first-year Griffins…Conklin made it 5-for-5 in victories for goalies who brought more than 100 games of NHL experience into their Griffins debut. He also became the fourth straight to win his first game at Van Andel Arena, joining Manny Legace, Chris Osgood and Curtis Joseph. Only Pokey Reddick lost his home debut, the Griffins' first game at Van Andel Arena on Oct. 11, 1996.
Three Stars: 1. GR Nyquist (power play goal, two assists); 2. HAM Geoffrion (power play goal, assist); 3. GR Conklin (W, 22 saves)
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The study, published in the Archives of Internal Medicine, included 246 women over 65 who were randomly assigned to either an exercise program or a wellness program for 18 months. The exercise program consisted of two 60-minute supervised exercise sessions and two 20-minute home exercise sessions per week. The exercises included stretching, balance and strength training, and aerobics, and exercise intensity was increased over time. The wellness program consisted of ten-week blocks of once-a-week, one-hour, low-intensity exercise sessions alternating with ten-week blocks of rest.
The exercise program improved:
The wellness program improved:
Bone mineral density did not change in the lumbar spine and decreased in the hip in this group, and the wellness program did not improve participants' chances of falling. The fall rate was 41% lower in the exercise group than the wellness group at the end of the study, and there were twice as many fractures due to falls in the wellness group compared to the exercise group, although this difference was not statistically significant.
"Our exercise program clearly demonstrated positive effects on the most relevant risk factors for elderly women: fracture and coronary heart disease risk factors," said lead study author Dr. Wolfgang Kemmler of the Institute of Medical Physics in Erlangen, Germany. "These findings add to the evidence that a regular high-intensity exercise program designed for the elderly improves overall fitness, maintains bone health, and reduces fall and heart disease risk."
If you plan to add exercise to your bone-loss prevention program, consider including the following elements:
(Arch Intern Med 2010;170:179–85)
Copyright © 2017 Healthnotes, Inc. All rights reserved. www.healthnotes.com


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Clinical Trial of the "Living Well With Hearing Loss Workshop"
- Full Text View
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|Hearing Loss Stress
|Behavioral: The Living Well with Hearing Loss Workshop Device: hearing aid services
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Clinical Trial of the "Living Well With Hearing Loss Workshop"
- Communication Profile for Hearing Impaired: Maladaptive Strategies Subscale [ Time Frame: 8 weeks post-baseline relative to baseline ]
The Communication Profile for Hearing Impaired (CPHI) queries subjects on how well they can communicate with others.
The Maladaptive strategies subscale describe behaviors that prevent the individual from coping effectively with communication problems.
8 week change score from baseline value. Larger values of the change score indicate less use of maladaptive behaviors. Larger group mean change score indicates BETTER performance on this scale.
CPHI Maladaptive strategies subscale ranges from 1 (better) to 5 (worse) maladaptive strategy usage.
- Communication Profile for Hearing Impaired: Verbal Strategies Subscale [ Time Frame: 8 weeks post-baseline relative to baseline ]
The Communication Profile for Hearing Impaired (CPHI) queries subjects on how well they can communicate with others.
The Verbal Strategies subscale describe adaptive strategies for coping with the effects of hearing impairment on communication.
8 week change score from baseline value.
Larger values of the change score indicate more use of adaptive Verbal Strategies.
Larger group mean change score indicates BETTER performance on this scale.
CPHI Verbal Strategies scores vary from 1 (worse) to 5 (best) strategy usage.
- Communication Profile for Hearing Impaired : Non-verbal Strategies Subscale [ Time Frame: 8-weeks post-baseline relative to baseline ]
The Communication Profile for Hearing Impaired (CPHI) queries subjects on how well they can communicate with others.
The Non-verbal Strategies subscale describe adaptive coping strategies but they describe unobtrusive, nonverbal behaviors that the individual can use to maximize communication effectiveness.
8 week change score from baseline value.
Larger values of the change score indicate more use of adaptive non-verbal behaviors.
Larger group mean change score indicates BETTER performance on this scale.
The CPHI Non-verbal strategies score ranges from 1 (worse) to 5 (better) usage of non-verbal strategies.
|Study Start Date:
|May 2007
|Study Completion Date:
|September 2010
|Primary Completion Date:
|February 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm 1
Group Aural Rehabilitation session, two hours in length, approximately 6 participants plus Group Facilitator
Behavioral: The Living Well with Hearing Loss Workshop
Interactive group session modeled on Patient-Centered medicine and Adult Learning principles; the participants are partners with the Group Facilitator who is a hearing rehabilitation professionalDevice: hearing aid services
Standard VA audiological hearing aid dispensing services
Active Comparator: Arm 2
Veterans receive new VA issued digital hearing aids per Standard VA Audiology Hearing Aid services
Device: hearing aid services
Standard VA audiological hearing aid dispensing services
Detailed Description:
Hearing aids are essential to the rehabilitation of veterans who have acquired hearing loss. However, as with most prosthetic devices, the use of hearing aids does not result in fully normal functioning, and research shows that residual handicapping effects of hearing loss recur for many veterans. Hearing loss now affects 31 million Americans and is increasing in prevalence due to the "graying of America" and the noise-traumas of modern life, including modern warfare. VA spent over $119,000,000 on hearing aid technology for eligible veterans in FY 2004.Therefore, evidence-based rehabilitation treatments to alleviate avoidable hearing handicaps is a priority for VA and non-VA audiology. VA audiology clinics, however, are forced by high work loads to follow tight schedules for fitting hearing aids, with little time available to counsel veterans on skills for dealing effectively with the auditory and psychosocial challenges specific to their personal life style.
The proposed study will present and evaluate a single session, two hour long rehabilitation treatment model, "The Living Well with Hearing Loss Workshop." This cost-effective group intervention draws from research in psychology and behavioral medicine, as well as audiology, to teach specific skills that empower veterans to self-manage the adverse consequences of their hearing loss. The workshops will use multi-media presentations to train participating veterans in cognitive, behavioral and affective coping skills, while the patient-centered process focuses on collaborative problem-solving of hearing-loss-challenges participants present to their groups as personally important.
This is a dual site, randomized clinical trial, conducted by Co-PIs Dr. Turbin, a psychologist and Investigator at the NCRAR in the Portland, Oregon VAMC; and Dr. Abrams, a rehabilitative audiologist and Chief of Audiology Services at the Bay Pines, Florida VAMC. We will recruit a total of 310 veterans, all patients at the VAMC audiology clinics in Portland or Bay Pines, who are: 1) recipients of their first hearing aids, 2) have a mild to moderately-severe hearing loss in their better ear, and 3) present no other condition that would preclude their participation in age-appropriate interpersonal activities. Half of these veterans will be randomized to each of our two treatments: the Control condition of routine VA hearing-aid-rehabilitation-alone, and our Experimental Treatment condition of routine audiology services plus our workshop intervention. All subjects will complete three questionnaires as Pre-test measures before hearing aid fitting, eight weeks after hearing aid fitting as Re-tests and then four months later as Post-tests. An additional personality inventory will be administered only at baseline, yielding co-variates for interpreting possible within-group variance. Workshop participants will attend their session within one month of hearing aid fitting. The workshops will be facilitated by audiologists we will train in our empowering, patient-centered, coping-skills based model.
We hypothesize that our Workshop participants will show enhanced personal adjustment and use of communication strategies when compared to both baseline and to Control subjects, and further hypothesize that our Workshop participants will exceed our Controls in self reported hearing aid benefit at Re-test, and retain these differential treatment benefits at Post-test. The outcome data will enhance our understanding about the coping processes by which people respond to their hearing disability and its treatment by hearing-aids-alone, and about how well Workshop participants learn and utilize the skills taught in our treatment model. The findings from this research can foster continued development and implementation of evidence-based rehabilitation treatments and, if shown to be effective, our model can be replicated at audiology clinics, adapted for video or online training, or used by other health care professionals or even lay mentors to enhance the quality of life of people who are hard of hearing.
|Ages Eligible for Study:
|18 Years to 85 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Subjects are users of new hearing aids with mild to severe hearing loss in better ear.
Exclusion Criteria:
- Patient has been in aural rehabilitation in the past 2 years, or has a condition besides hearing loss that affects age-appropriate social activity.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00323427
|United States, Florida
|VA Medical Center, Bay Pines
|Bay Pines, Florida, United States, 33708
|United States, Oregon
|VA Medical Center, Portland
|Portland, Oregon, United States, 97201
|Principal Investigator:
|Mitchel B Turbin
|VA Medical Center, Portland
Additional Information:
|Responsible Party:
|VA Office of Research and Development
|ClinicalTrials.gov Identifier:
|NCT00323427 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 5, 2006
|Results First Received:
|September 26, 2013
|Last Updated:
|January 17, 2014
Keywords provided by VA Office of Research and Development:
Coping behaviors
Hearing aids
Hearing impairment
Patient-centered care
Psychological adaptation
Psychological adjustment
Social adjustment
Aural Rehabilitation
Additional relevant MeSH terms:
Hearing Loss
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
ClinicalTrials.gov processed this record on September 19, 2017


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Shopping for someone else but not sure what to give them? Give them the gift of choice with a Mother & Child Maternity gift card. You select the amount, she selects the gift!
Gift cards are delivered by email and contain instructions to redeem them at checkout. Our gift cards have no additional processing fees.
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If you have any queries or concerns, please email or telephone us on 07 3161 9420.
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This article, entitled "The Best Learning Tool for Toddlers," comes from Liz Hayes, MomsEveryday correspondent from Central Wisconsin.
It turns out that you are the best learning tool for your toddlers, and the most effective way to teach them valuable skills and vocabulary while preparing them for preschool is by talking and reading to them! It's so simple – but so effective.
Read to your children often so they learn that information comes from books. Studies show that children who are read to at home are more successful in school than those who are unfortunately not. They'll develop a vocabulary when you read to them and learn about fun adventures. Reading twenty minutes a day is the golden standard, and it doesn't have to be all at once.
Talking to your child is another simple way to make sure he or she gets on the path to education. Point out different objects, narrate your day and take your child on short trips. When you talk to your toddler, you're encouraging him to comment, ask questions and develop communication skills.
Toddlers are primed for learning. Engage with them, read aloud to them and witness how they blossom right before your eyes!