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Open Label Study of 908/RTV in Combination With Other PIs for the Treatment of Multi PI-Experienced HIV Subjects
This study has been terminated.
(Incomplete data)
Information provided by:
ClinicalTrials.gov Identifier:
First received: September 1, 2005
Last updated: November 9, 2007
Last verified: November 2007
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
For HIV-infected individuals with highly resistant viruses, higher drug levels may be required to block the virus. This study investigates that concept by comparing the efficacy of standard fosamprenavir/ritonavir to an increased dose of boosted fosamprenavir and to a combination of fosamprenavir (increased dose)/lopinavir/ritonavir.
|Drug: fosamprenavir/ritonavir (700mg/100mg BID) Drug: fosamprenavir/ritonavir (1400mg/100mg BID) Drug: fosamprenavir/lopinavir/ritonavir (1400mg/533mg/100mg BID)
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase III, Randomized, Controlled, Open-Label, Multicentre, Three Arm Study to Compare the Efficacy and Safety of a Dual-Boosted HIV-1 Protease Inhibitor Regimen of Fosamprenavir/Lopinavir/Ritonavir 1400mg/533mg/133mg Twice Daily and an Increased Dosage Regimen of FPV/RTV 1400mg/100mg BID Versus the Standard Dosage Regimen of FPV/RTV 700mg/100mg BID for 24 Weeks in Multiple-PI Experienced, HIV-Infected Adults Experiencing Virological Failure
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Ritonavir Lopinavir Fosamprenavir Fosamprenavir sodium Fosamprenavir calciumU.S. FDA Resources
Further study details as provided by GlaxoSmithKline:
Primary Outcome Measures:
- The average area under the curve minus baseline [AAUCMB] in plasma HIV-1 RNA at 24 Weeks when each are administered in combination with an optimised background therapy, in a multiple PI-experienced population experiencing virological failure. [ Time Frame: 24 weeks ]
Secondary Outcome Measures:
- Efficacy (AAUCMB) at 48 weeks, safety, tolerability(incidence and nature of AEs and laboratory abnormalities) at week 24 and 48, CD4 change from baseline at week 24 and 48, and the steady-state plasma APV and LPV through concentrations. [ Time Frame: 48 weeks ]
|Estimated Enrollment:
|Study Start Date:
|March 2005
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion criteria:
- Multiple protease-inhibitors experienced HIV-1 infected individuals experiencing virological failure and who's virus is not fully resistant to boosted fosamprenavir and boosted lopinavir based on genotypic resistance tests.
Exclusion criteria:
- No full resistance to FPV/r or LPV/r
- Planned use of NNRTIs as part of the study salvage regimen
- Application of additional exclusion criteria as determined by physician.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00144833
Show 42 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00144833
Show 42 Study Locations
Sponsors and Collaborators
|Study Director:
|GSK Clinical Trials, MD
More Information
Keywords provided by GlaxoSmithKline:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|ClinicalTrials.gov Identifier:
|NCT00144833 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 1, 2005
|Last Updated:
|November 9, 2007
Keywords provided by GlaxoSmithKline:
Protease inhibitors-experienced HIV-1 infected patients
Highly-resistant HIV-1
Dual boosted Pis
Additional relevant MeSH terms:
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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Every day, the fight for LGBT equality continues. We have made some huge strides forward — DADT repealed, the hate crimes law passed, legal marriage in some jurisdictions — but we have also had some huge setbacks. Sometimes, it's really easy to get frustrated at our snail-like progress. And sometimes, it's really difficult not to get depressed and disheartened when you see the hate and outright ignorance from some people. (Read some of the comments from some folks here on Instant Tea if you want to see what I mean.)
So sometimes, we need a little perspective.
A friend of mine e-mailed me the link to the video below, and I found it so touching that I decided to share it here with our Instant Tea readers. As you watch, remember to never give up the fight. Remember how far we still have to go. But also remember how far we have already come.

subset: commoncrawl


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FACTS first. We are fourth in the Blue Square Conference - Hooray, but top of the card count table - oh dear.
We have accrued 45 yellows and six reds. This is too many. Our on the field disciplinary record is costing us league points. Our opponents are scoring goals from the many free-kicks awarded against us.
The last two matches prove this. Hyde scored their equaliser from a set piece and the initial Stockport goal came direct from another. It put them in the driving seat. We got one point from six. Both goals changed each match. Five points slipped away.
Rovers are not a dirty side and perhaps may not have had the rub of refereeing green but that is no excuse. Free-kicks are happening too often and the season has shown that defending them is not a strength. In difficult playing conditions accidents can happen so a little more caution please gentlemen.
Much more satisfaction can be taken from looking at the league table. I suspect that being fourth in January is something we would have all taken at the start of the season. The big question is can it be maintained or even improved upon?
It must be. The squad is capable of it. This end of the season is no time for faint hearts. It is no time for 'show ponies'. Our players must stand up and be counted, and earn the generous contracts some of them are on.
This column has consistently admired Reece Styche and with good reason. When I first wrote about him I referred to him playing on the edge. Some readers think he sometimes goes beyond it.
Perhaps so but that is what makes him the player he is. Does he not have the speed, the devilment and the proven scoring record to give the team the cutting edge it needs?
I think he does and would select him to play with Matty Taylor and James Norwood in a speedy front three. Both James and Reece would benefit from Matt's ability to hold the ball up, and then set them free. Our last two goals have come in that fashion. If this selection does not work we have a bench of game changers, but I am convinced Reece should start every game.
This is very much a winter wonder land column. The challenges of Cowcombe Hill or the 'W' were ones I was not prepared to tackle on Saturday. Staying at home gave me the opportunity to study the fixture list. Eleven home matches are left, and only six away fixtures. Make the New Lawn a fortress and there is no limit to what can be achieved.
TRANSFER window conjecture continues, and why not? It brings extra interest to offset midwinter blues.
Rovers have released one player obviously surplus to requirements and added one more in Obudade who can add a much needed extra dimension. Rumours about Reece abound and this is not surprising.
Keep him please unless someone offers crazy money. Perhaps we should remember two things. Much of the gossip we hear may be agent inspired is the first, the second being that even with Wilmott and Jolley in the side Newport lost at home to Barrow. Signings - however attractive may not be the answer.
Perhaps one answer was given in recent Ecotricity/Dale Vince news stories.
The investment placed into our club was said to be as much as £900,000. This is a huge sum, however wealthy the chairman is. In no way am I denigrating the outstanding efforts of the past, but rather taking a reality check.
As football fans we need to be realistic. Running a successful club costs money - much more in fact than comes through the gate.
We know that our chairman's aim is future promotion. We can help by becoming a vocal 12th man - encouraging the team to win those all important home fixtures.
Remember we are already fourth, a play-off position.


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Zonex TR10 - TR10 10" ROUND DAMPER
Zonex TR10 - TR10 10" ROUND DAMPER. This product is a brand new genuine Zonex OEM part.
Zonex TR10 - TR10 10" ROUND DAMPER
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If you have any questions regarding this product please feel free to email [email protected] or call 1-855-932-4822 and one of our friendly Customer Experience Representatives will be more than happy to help.


text:
Dove Damage Therapy Frizz Control Taming Cream Reviews
no frizzmy dry curly hair had no frizz and perfect definition. this creme smells awesome and is perfect for flyaways. i felt like it really made my curls perfectly shaped. the quality is excellent and it truly lasts all day (if you put enough creme in you hair, as with any product) — 6 years, 8 months agokenya | 504 reviews
This review is: Helpful | Not helpful | Inappropriate | 4 of 6 people said helpful
Great for thinner hair!This is very light-wieght, great for thinner, less coarse culy hair! The price can't be beat -- and Dove is really supporting many Women's causes today! — 6 years, 8 months ago1955Nurse | 234 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 4 people said helpful
good valueI love the smell of the product too though which makes me go through a lot of it in a shorter amount of time. So even though you don't see this kind of stuff in the salon doesn't mean that it isn't as good. In fact I kinda like this one better than anything that my hairdresser uses. — 7 years, 1 month agomamacita11 | 234 reviews
This review is: Helpful | Not helpful | Inappropriate | 1 of 3 people said helpful
Please put this item back in my local WalMart!!!!!This is the only product that makes me love my hair. It makes it so easy to control. I've tried other countless products, and this is my absolute favorite! I love the scent & weightlessness of this taming cream. Please put it back in the Lehighton, PA WalMart!!! I can get it on Amazon.com, but I hate to pay the shipping cost! — 6 years, 4 months agotracyjo | 1 reviews
good for the price.this is a nice frizz control cream. it's really light, doesn't make hair greasy, and works quite well. it's not my favorite, and you probably need to layer the product with something else. overall, it's good, but not the best. — 6 years, 6 months agoRawrrr | 30 reviews
i hate frizzi tried that stuff and it worked really good in my hair i have curly hair and it made my curls soft and silky so thank you dove products — 6 years, 10 months agokelly_svejda | 1 reviews
Not badIt's amazing for it's price, hard to find where I am. — 6 years, 8 months agoJerseylady77 | 8 reviews
Does NOT WORKI used this product and it did nothing for my thick hair. Even If I would put on as directed or a bit less it would be to heavy for my hair. It also made my hair too oily. I like dove products but this one just failed to deliver frizz control. — 6 years, 8 months agoCastaDiva | 3 reviews
frizz be goneI love this product!! I purchased it locally from walmart, but recently its been discontinued! It smells great and doesn't have an oily base to make your hair look greasy! Just dab a little on your hands and rub it on your hair! it works! — 7 years, 1 month agoLadyfox | 7 reviews
A M A Z I N GI have been using this product for about two years, and I LOVE IT, honest to god my hairdresser you to tell me my hair was dry but after i started using this she said she noticed my hair was SUPER SOFT, every time I visit her she compliments me on my hairs softness, i can 100% say it's because of this cream. It's cheap and very much worth the buy trust me..also on the plus side it smells delicious — 7 years, 1 month agosleighb7 | 3 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 2 people said helpful
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My Reasons for Reporting This


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Chuck Kennedy wrote:Note that you cannot always run up. But you can always stand and deliver. Thus, the simple logic of learning to throw as far and as accurately as possible with no run up needed. You throw primarily forehand and I throw backhand so that may make a difference. I'm guessing my knees may be in better shape although not necessarily due to disc golf?
The same logic also follows for champs like Barry schultz who have determined that straddle putting is the most logical primary putting stance. You can almost always straddle putt from most locations. In fact you usually have two stance options to the left and right from your mini. There's only one foot forward alignment and you are hindered from doing that many times in the woods.
Haha. This is crazy logic even by Mad Scientist standards. Perhaps I should always throw while sitting on my butt. Because no matter the footing I can always sit down. Perhaps I should learn to throw while blindfolded to be ready for blind holes, darkness or loss of sight.
Disc golf requires adaptability due to the various challenges. So it is not like a free throw in basketball where a player can use just one form because the shot never changes. We have to be able to straddle putt and loft putt and forehand and backhand and roll and overhead and yes, stand-and-deliver, as dictated by the shot. But the odd exception should not dictate the general rule.
For our primary driving form we should develop a form which places the least strain on our bodies and maximizes power and control. Very few players would adopt stand-and-deliver based on this standard. Oh, and very few players actually use stand-and -deliver. More importantly, if we rely on the lessons of the best players stand-and-deliver remains exceptionally rare, including Barry Schultz who uses a run up.
Since putting is the shortest shot it places the least strain on our bodies and so is a weak analogy to driving. Since putting is the hardest and most important shot to master we need to use a primary form which works best for each of us. I'm guessing that if Barry Schultz was a significantly poorer putter from a straddle position then he would only do so when forced by the circumstances.


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You have heard the expression, "save my bacon."
The new web site for advocating for preservation of the U.S. tomato agreement with Mexico is, no kidding, www.savemytomato.com.
The web site opens up with a series of appealing photos, alternating between mom and family creating a salad, an attractive woman buying tomatoes at a retail store and a smiling produce clerk. The web page has a tag line "support free trade." and messages like "Don't let special interest groups take a bite out of your pocket."
The opening web page links to an ad that will run in several publications, featuring a blue-eyed six-year old girl with a "Dear President Obama" letter in the background.
Will this slick web site and effective messaging save the bacon of the fresh tomato industry in Mexico? It won't hurt, I'd say.
Meanwhile, here are some excerpts from the FPAA press release announcing the "savemytomato" web site:
An influential group of businesses, agricultural and food industry organizations warn that special interest efforts to abolish a 16-year U.S. tomato agreement with Mexico could lead to a trade war costing the American economy billions of dollars in exports and tens of thousands of jobs.
A growing number of industry leaders, including the U.S. Chamber of Commerce, National Restaurant Association, Wal-Mart and nearly a dozen meat, dairy and poultry producers' organizations, is asking the Obama Administration to continue the long-standing agreement with one of America's largest trading partners.
"Termination of the tomatoes agreement will benefit no one and will lead only to uncertainty and unpredictability in the market," Wal-Mart officials wrote to the Commerce Department.
The National Restaurant Association, the leading business organization for the restaurant and food service industry, wrote, "Unpredictable, and possibly higher tomato prices could negatively impact industry operations." The U.S. food and restaurant industry accounts for more than one-third of all the tomatoes consumed in America, according to the trade group.
Agricultural groups representing meat, dairy and poultry producers say they are concerned about impact of a trade war on jobs and their industries.
"The $100 billion U.S. produce market is now globally integrated, and up to $7 billion of the industry is comprised of fruits and vegetables from Mexico, affecting tens of thousands of U.S. workers," Raul M. Grijalva (D-AZ) wrote in a letter to the Commerce Department. "Ending this agreement will put people out of work, reduce the variety and quality of tomatoes available to consumers and hurt all Americans by raising prices at the supermarket check-out line."
TK: This is a well-coordinated strike in the public relations battle between Florida and Mexican tomato interests, as it brings in the perspective of other ag groups concerned about trade disruptions with Mexico. I have to wonder if the consumer will seek out and connect with the "savemytomato" message, but this web effort hits all the right simple notes for consumers unfamiliar with the issue.


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With the San Francisco Museum of Modern Art's "Project Los Altos: SFMOMA in Silicon Valley" slated to open next month, museum representatives visited the Rotary Club of Los Altos Oct. 17 to discuss the exhibition.
While SFMOMA undergoes extensive renovation, the museum has shipped some of its inventory for temporary installation at sites around the Bay Area. "Project Los Altos" runs Nov. 9 through March 2.
SFMOMA's Janet Bishop, curator of painting and sculpture, and Katie Tamony, director of marketing and communications, previewed the exhibition, which features the artwork of nine contemporary artists, including two with local ties.
Charles Garoian, former art teacher at Los Altos High School and current professor at Pennsylvania State University, is among the participating artists.
A trilogy of videos by Jeremy Blake highlights the Winchester Mystery House in San Jose, built by the eccentric Sarah Winchester, who owned the 100 acres that later became Los Altos.
The exhibition also comprises seven new commissions, including a film by director Mike Mills, who interviewed the children of local high-tech workers about their expectations for the future. Graphic artist Jessica Stockholder's contribution, "Cross Hatch," is already on display: She used the intersection of State and Fourth streets as her colorful canvas to showcase a geometric abstract painting.
Passerelle Investment Co. funded 20 artist videos to accompany "Project Los Altos."
SFMOMA is conducting an extensive marketing campaign targeting audio, video, online and print media to publicize the exhibition. The museum's members' magazine describing "Project Los Altos" will reach 30,000 households, many are expected to visit the various works on display.
Tamony also spotlighted some of the SFMOMA on the Go exhibitions planned for other cities, including "Flesh and Metal: Body and Machine" at Stanford University's Cantor Arts Center; "Beyond Belief: 100 Years of the Spiritual" at San Francisco's Contemporary Jewish Museum; 23 pieces of SFMOMA's Matisse collection at the San Francisco Legion of Honor; and eight monumentally scaled sculptures by Mark di Suvero at Crissy Field in San Francisco.
For more information on "Project Los Altos," visit sfmoma.org/exhib_events/exhibitions/572.
Marlene Cowan is a member of the Rotary Club of Los Altos.


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Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients (ICUPtO2OCT)
Recruitment status was: Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human subjects. Patients had negative O2 challenge test results, indicating that flow-dependent O2 consumption might have been present. Recent reports using the noninvasive transcutaneous PO2 (PtO2) and transcutaneous partial pressure of carbon dioxide probes have observed a relationship between low oxygen challenge test values to mortality and organ failure. The OCT values provides an accessible noninvasive method of detecting early shock.
To date,these studies of OCT in the ICU patients are rarely. No one has quantified OCT to CI, DO2I、ScvO2.
This study explored:
- relationship between patient factors, hemodynamic variables, PtO2, and OCT to mortality;
- relationship between PtO2 index, tissue oxygen index, oxygen Challenge index to CI, DO2, ScvO2.
|Sepsis Shock
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Assessment of Transcutaneous Oxygen Tension and Oxygen Challenge Test in Adult Intensive Care Patients
- ICU mortality [ Time Frame: 28 day after enrollmented ]
- hospital mortality [ Time Frame: 28 day after enrollmented ]
|Estimated Enrollment:
|Study Start Date:
|September 2009
|Estimated Study Completion Date:
|October 2010
|Estimated Primary Completion Date:
|October 2010 (Final data collection date for primary outcome measure)
|Survivor Nonsurvivor
Detailed Description:
PtO2 index = PtO2/PaO2;tissue oxygen index=PtO2/FiO2;
5min OCT value = challenged 5minPtO2 - PtO2baseline;
10min OCT value= challenged 10minPtO2- PtO2baseline;
oxygen challenge index = (10minPtO2- PtO2baseline)/(10minPaO2-PaO2baseline)
|Ages Eligible for Study:
|18 Years to 95 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Inclusion Criteria:
- 18 years of age or older
- Requiring a artery catheters, and pulmonary artery catheters or PiCCO-plus or central venous catheters
- FiO2<80% and SpO2>92%
- Consent informed
Exclusion Criteria:
- Not expected to live
Please refer to this study by its ClinicalTrials.gov identifier: NCT01174966
|Contact: dawei liu, MD
|Contact: huaiwu he
|China, Beijing
|Peking Union Medical College Hospital
|Beijing, Beijing, China, 100730
|Contact: dawei liu, MD 010-65296091 email@example.com
|Contact: huaiwu he 010-65296094 email@example.com
|Sub-Investigator: huaiwu he
|Principal Investigator:
|dawei liu, MD
|Peking Union Medical College Hospital
|Responsible Party:
|Da wei liu, MD , Professor , Director of Department of Critical Care Medicine, Peking Union Medical College Hospital
|ClinicalTrials.gov Identifier:
|NCT01174966 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 2, 2010
|Last Updated:
|August 3, 2010
Keywords provided by Peking Union Medical College Hospital:
oxygen challenge test
Oxygen Delivery Index
cardiac output index
ClinicalTrials.gov processed this record on September 21, 2017


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chainsmoker wrote:If someone has a cure for the cracking skin on my thumb it will be the greatest thing I figure out. One time it was so bad I was playing in an ice bowl event and I had little spots of blood on my white dx Roc. Currently I put super glue in the cracks.
Whichever stuff you use i'd begin with argan oil because it is chock full of vitamin E and once that has absorbed into the skin (only a few minutes) apply something heavier in a thick layer and put a disposable fabric glove on and wear that for 12 hours and repeat twice a day. I've seen a competition cross country skier do that for a month. So things like that could last a while but i hope that cracked skin on the thumb won't last a month to cure. Also does applying sports tape to the tip of the thumb leave you with enough grip to be able to throw? It should help in alleviating some of the pressure in throwing and i'd try that even if it messes up your score at first when you return to throwing.


text:
Coil, Street Fire, Ford 4.6/5.4L 3-Valve 04-08 Single
Single coil, direct bolt-in to factory connectors
$26.53 Suggested Retail
$23.88 Your Price
$23.88 Your Price
Free Shipping on orders over $100*
In Stock
These coils mount directly in place of factory style versions and accept the OEM connectors as well. Performace output is improved thanks to a careful selection of better materials and efficient winding ratios.
|Street Fire
|Emission Code
|California Proposition 65
This part is legal for use on Emissions Controlled Vehicles when used in accordance with the manufacturers application guide because it has a California Air Resources Board Executive Order number or is a direct or consolidated replacement part.
The following vehicles are considered Emissions Controlled Vehicles:
- 1966 and newer U.S. manufactured California Certified vehicles
- 1968 and newer U.S. manufactured Federally Certified vehicles
- 1968 and newer Foreign manufactured vehicle
WARNING FOR 5513: This product contains chemicals known to the State of California to cause cancer and birth defects or other reproductive harm.
*Free Shipping & Handling only offered to the continental US on orders over $100.
Some parts are not legal for use in California or other states with similar regulations.


text:
Because no collectible should be left uninsured... even dolls.
Throughout the year Collectibles Insurance goes to about 50 collectibles shows. Most of them are really cool - San Diego Comic-Con, New York Comic-Con, Chicagoland Juke Box Show, National Sports Collectors Convention, and the Las Vegas Gun Show to name a few. Unfortunately I do not get to go to any of these... I am the designated Doll Show representative.
I just returned from my first of 2011: The International Doll Expo - IDEX. Despite being held in Orlando in January, I do not always look forward to this show... #1 occasionally it falls on the same weekend as the Super Bowl and I find myself flying home on Super Bowl Sunday and #2 some of the dolls give me the willies...
BUT, there are some really cool dolls that I think Action Figure Collectors might be interested in taking a closer look at.
I am always amazed by the Tonner Doll Company's exhibit...
Horsman's exhibit was edgy Urban dolls meets HGTV!
And for those of you with little ones at home, Madame Alexander never fails… Pinkalicious, Fancy Nancy, and now Eloise.
They also carry an awesome line of 18" dolls, Favorite Friends that rivals that other 18" doll company. I was lucky enough to bring a few home for my little girls!
Take a few minutes to protect whatever kind of action figure (or doll) you collect - - Get a quote today! Call 888-837-9537 (8:30-5pm ET) or online at www.collectinsure.com/cost.html.
When calling or completing an application, be sure to indicate you are a member of Figures.com in order to receive 5% off your first term premium.
About Collectibles Insurance Services, LLC (www.CollectInsure.com)
Since 1966, Collectibles Insurance Services has been "insuring today's treasures from tomorrow's tragedy." As a company founded by fellow collectors, we understand that your collection is worth so much more than just money. And as experts in collectibles insurance, we know standard homeowners insurance alone isn't enough to replace your treasures.


text:
Are you looking for ways to cut feed costs or wondering what commodity is really the best buy? If so, make plans to attend the "Alternatives, Strategies, Decisions" Feed & Nutrition Conference on Tues., Sept. 25 or Wed., Sept. 26. The conference is brought to you by the Professional Dairy Producers of Wisconsin.
The same program will be offered in two locations and walk-ins will be accepted at no charge. Plan to attend on:
Tuesday, Sept. 25 in Stevens Point, Wis., or Wednesday, Sept. 26 in Madison, Wis.
Each conference day will begin with registration at 9:30 a.m. and conclude by 4:30 p.m. The conference line-up includes presentations by Victor Cabrera, University of Wisconsin dairy scientist; Mike Hutjens, University of Illinois extension dairy specialist and Dan Undersander, University of Wisconsin forage agronomist.
To view the full agenda, click here.
Invest just one day and bring information back to your dairy that could make all the difference for you, your cows and your business.


text:
Reducers provide a smooth transition between floors of different heights.
Planning your new remodeling project?
Reviewed by 2 customers
I had to use an adhesive since I was attaching the trim to a concrete base. I used liquid nails and it worked great. First I attached a few pieces of shim and then the metal piece, which holds the trim down.
Make sure not to glue the trim directly to your wood floor or it will squeak whenever you walk over it.
You will also need a mitre saw if you plan to have corners/angles.
Overall, It looks great!
Best Uses
I have it everyplace but two bedrooms (and kitchen and bath, which are tile). Wish I had it in bedrooms, but it was a gift; purchased and installed by my son, so he got to make that decision.
We deal with dogs and kids, so carpet gets stained despite your best efforts. Now no worries!
Do you have questions about this product?
AnswerBox - Get answers from Staff Experts and real customers by clicking "Ask a question" or click here to ask our Customer Service Team
Q:Does this transition come with the U-channel/track? If yes, is the track metal or plastic?
1 answer
A:Yes it will come with a U-track; generally plastic.


text:
THE Royal Marine Corps is celebrating its 350th anniversary this year – and plenty of people will hopefully be drinking to the special birthday.
Wiveliscombe-based Cotleigh Brewery and Sheppy's Cider, of Bradford-on-Tone have produced an RM350 Limited Edition ale and cider to commemorate the occasion.
And 10p from every pint of the limited editions will go to Go Commando, set up by the late Sean O'Brien to support the Royal Marine family.
So far the two companies have donated over £18,000 to the charity.
Members of 40 Commando Royal Marines, based at Norton Manor Camp, in Norton Fitzwarren, are holding an anniversary weekend next month.
On Friday, June 20, 40 Commando are hosting a dinner in aid of the Royal Marines Charitable Trust Fund at the County Ground, Taunton – tickets are available from Norton Manor Camp.
The following day, the troops will march through Weston at 11am to mark being granted the freedom of the town, an honour already bestowed on them by Taunton.
Later the same day, the Royal Marines 1664 Challenge Team, who are running 1664km around the UK, having previously skied, sailed and cycled the same distance in Europe, will arrive in Weston, supported by members of 40 Commando running a marathon finishing on the seafront.
40 Commando spokesman Lieut Brendan Ford RN said: "40 Commando are proud to be part of such a welcoming and supportive community and the support shown towards the unit, especially over recent years, has been fantastic.
"The opportunity to celebrate our 350th birthday is a unique opportunity and one we hope you will all be able to support."


text: (Photo by Matthew Sharpe/Getty Images) [ Best Receiving Corps In NFL History By Steve Peloquin July 6, 2011 What group of receivers ranks as the very best in the history of the NFL? Read More Category: National Sports Tags: art monk, gary clark, isaac bruce, jerry rice, marques colston, new orleans saints, nfl, st louis rams, torry holt, washington redskins Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
All-American Amusement Co., Inc.Serving: Connecticut, New York, New Jersey, Pennsylvania
MORE THEN 48 YEARS OF PROFESSIONAL SERVICE - Read More
Foto Master | B2B Virtual Graffiti WallsServing: New York City NY
Choose one or all of our three elaborately inventive, interactive photo favors for your next party. Become a bobble head, partake of digital spray paint, or dance through a... - Read More
Giant Games of NYC
Interactive games rentals are an easy way to entertain guests of all ages at your next party! Arcade game rentals, simulators and interactive games all make for some great exercise as well as a thoroughly enjoyable time! Search here for Interactive Games Rentals in Brooklyn.


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The designs of the grand pianos are based upon more than 150 years' experience. At the same time, they include the most recent updates and represent an even stronger commitment to an ideal transparent sound, fullness and richness of overtones, and the greatest possible degree of adaptability. There are five models available, from E-272 to A-170.
On all models, active string sections between the bridge and hitch pins purposefully enrich the overtones within the principle of an integrated sound. All frames are "open," i.e., designed without forward cross-braces. This offers great advantages for una corda (soft pedal) playing, as well as for the extended techniques which Contemporary Music requires. Fast-responding key action without "aquaplaning" - with hygroscopic white keys in an ivory substitute and black keys in solid ebony - make for enjoyable playing. Mammoth ivory for the white keys is optional, as are special features like knuckle rollers, the new energy transmission system in the Phoenix model, and weather-resistant, carbon-fibre soundboards.
Many pianists have rated the E-272 as one of the most distinctive and outstanding concert grands on the market. When tested in Bastille Opera Paris its sound was qualified best for the interpretation of Bach, Mozart and Beethoven and its competences for Contemporary Music were proved.
Teatro Nacional Sucre Quito Ecuador, Hochschule für Musik Karlsruhe, Janácek-Academy Brno (CZ), Vienna Konzerthaus, Philharmonie Berlin...
Download the E-272 info sheet here.
D-232 is the little brother of the E-272 – a classic grand piano for professionals, universities and mid-sized halls. The new capo d'astro bar is conducive to an especially singing tone and enriching the softest pppp to the most energetic ffff; covering 46 notes, this capo d'astro bar is the only one of its kind worldwide.
"Utzon" grand piano in Bagsværd Kirke Kopenhagen, Royal Academy Stockholm, Music Universities Munich, Vienna, Karlsruhe etc.
Download the D-232 info sheet here.
was introduced at the beginning of 2009. It is the direct descendant of the Steingraeber Liszt Grand Piano, the legendary model 205. The bass* has been enhanced and adapted to twenty-first
century requirements, while the previous design has undergone only moderate alterations.
The allure of the Steingraeber 205, which has fascinated pianists like Franz Liszt, Richard Strauss, Engelbert Humperdinck and, more recently, Daniel Barenboim, has been preserved. Because of its differentiated sound spectrum and registers, this model is in use for lieder recitals, in recording studios and music conservatories (e.g., Munich, Paris, Hannover), and at New Music festivals.
* The bass has been enriched with greater volume. Comparison of the 205 and the C-212:
- vibrating soundboard +4.8% / string length up to +5.8%
- the action, keyboard, and string lengths for notes 36-88 are identical
Download the C-212 info sheet here.
The B-192 is the latest Steingraeber design and closely modeled on the Steingraeber grand C-212 and thus the 2nd descendent of the famous Liszt piano from 1873. Very long bass strings on a similar scale to those of a chamber music grand are conducive to its wide range of sound. This piano transfers private homes into a concert salon; the B-192 is also well suited to discerning professionals and for use in music conservatories. The official production started in 2013.
Music University Trossingen, Music University Lucerne
Download the B-192 info sheet here.
We don't consider our Salon Grand Piano A-170 to be a "baby grand," because it impresses one as much larger than its 170 cm (5'7") would suggest. Its
projection and volume are truly surprising for an instrument of its size. In physical terms, this phenomenon is based upon its unusually wide tail, which results in very long bass
strings. The bass bridge also manages to do without bridgework, just like large grand pianos! The sophisticated, action mechanism, built to the highest specifications, makes it a
truly professional instrument.


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The Toyota Prius hybrid was the bestselling vehicle in California during the first quarter of this year, narrowly outpacing Honda's redesigned Accord sedan.
Toyota posted sales of 15,661 of the hybrids, leading the Accord's sales of 15,369 cars. The Honda Civic was third with sales of 14,918, according to data compiled for the California New Car Dealer's Association by auto research firm R.L. Polk & Co.
The Prius wrested the annual California sales crown from the Civic last year. Nationally, Ford's F-series pickup truck is the top-selling vehicle.
Hybrid sales continue to be on the upswing in the state, according to the dealer trade organization, reaching 7.5 percent of all vehicle sales. Helped by the hot-selling Tesla Model S, electric cars also are making gains, accounting for 1 percent of the California market during the quarter.
Overall, vehicle sales in the state grew 12.6 percent in the quarter, a brisker rate than the 7.2 percent gain logged by the auto industry nationally, according to the dealer group.
The domestic brands saw the fastest growth, logging a nearly 18 percent gain in registrations and increasing their market share to 28.4 percent from 27.1 percent in the same period a year earlier. Their gains came at the expense of South Korean automotive siblings Hyundai and Kia, which both lost ground in the state the first quarter.
Japanese brands continue to dominate the California market, accounting for 48.4 percent of sales, unchanged from the first quarter of last year.
The Dodge and Subaru brands were the fastest growing in the state during the quarter.


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Larry King interviews Dodger legend Eric Karros for "Larry King At Bat"
LOS ANGELES, CA - SportsNet LA is the exclusive 24/7 TV network of the Los Angeles Dodgers that takes fans behind-the-scenes of the team and offers in-depth access into the organization, providing an immersive experience with never-before-seen content and thousands of hours of comprehensive Dodger programming. This Sunday, August 24 at 5:00 p.m., SportsNet LA will debut "Larry King At Bat With Eric Karros," as the Dodger legend tells the talk show king about his playing career, his broadcasting career, Vin Scully, Tommy Lasorda and his thoughts on steroids. The hour-long episode debuts following SportsNet LA's live coverage of the Dodgers game against the Mets.
Karros spent 14 years in the Major Leagues and 12 seasons with the Dodgers. He is the Los Angeles Dodgers' all-time home run leader and won 1992 National League Rookie of the Year award, among many other honors. He now works as a baseball color commentator.
A preview of "Larry King At Bat With Eric Karros" is available at http://www.sportsnetla.com/content/snla/shows/larry-king-at-bat-dodgers-show.nbz6QfQVRsj0.html.
Quote excerpts from the episode include:
On Tommy Lasorda: "The thing that separates successful managers from others is the ability to get their guys in the clubhouse to believe in them and basically to run through a wall for them, and Tommy was that guy."
On baseball broadcasters: "What makes a good color man? A great play-by-play man. Really…a play-by-play man can make the color guy look great or just absolutely make him look horrendous."
On steroids: "I would say I was tempted, but I was so scared to do it that I didn't...If I would have been the 24th or 25th guy on the team, where [it's] the difference between playing in Albuquerque or the Dodgers, or I'm not a starter…I can't sit here and say that I wouldn't have done it or tried it. I can't."
The "Larry King At Bat" series features the iconic, award-winning TV and radio personality and lifelong Los Angeles Dodgers fan interviewing celebrities, baseball legends, Dodger personalities and other luminaries. Subjects to date have included Kareem Abdul-Jabbar, Orel Hershiser, Tommy Lasorda, Conan O'Brien and Joe Torre.


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ODI cricket history through Impact Index - part 2. Click here for Part 1
Continuing in our series of pieces on each country's ODI history, we move here towards West Indies. From 1973 to 2012 (before the current series in England), West Indies played 670 matches and won 347 with a win loss ratio of 1.18. Their highest score is 360, lowest 54. They won the World Cup twice, in 1975 and 1979, and finished as runners-up in 1983.
We present three lists - of players, batsmen and bowlers. The minimum qualification to be on these lists is to have played 75 matches. A match is considered in this system only when there is a result, and if the player has bowled or batted, as the case may be.
Here are the highest impact ODI players in West Indies' history:
Quite unsurprisingly, the majority of this list is packed with players who represented West Indies during its golden era of world domination (1973-1994). Also evident is the gap in the quality between the old warhorses and the relatively new flag bearers of West Indian cricket. It is also interesting to note that only 4 players on this list belong to the current playing generation of the West Indian team.
Viv Richards, unsurprisingly, tops this list. He is pretty much the Bradman of ODI cricket - unparalleled in his achievements. On top of that, he is actually also an all-rounder (his Bowling IMPACT also comfortably crosses 1). His tally of 9 SDs (series or tournament-defining performances) is also the fifth highest in the history of ODI cricket. Interestingly, 6 came purely for his batting, 3 as an all-rounder. Moreover, West Indies never lost a series under his captaincy and as a result he is also the second-highest impact captain for West Indies after Clive Lloyd.
The most surprising name on the list for many is that of Carl Hooper's - number 2 here. Being under the shadow of Brian Lara camouflaged his remarkable impact - his all-round consistency (with a very low failure rate of 29%, given the span of 227 matches), those seemingly innocuous off-breaks, his sharp slip fielding (his Fielding IMPACT is the second-highest amongst West Indians) and reasonably decent Captaincy IMPACT - all adding up to a giant - unsung till now.
All the West Indian bowling greats also make this list at quite a high position, namely Michael Holding, Joel Garner, Curtly Ambrose, Courtney Walsh, Malcolm Marshall and Ian Bishop. If the cut-off is reduced to 50 matches, Andy Roberts makes up the missing block of the famed quartet in this chart.
Jeff Dujon and Ridley Jacobs are the two wicket-keepers who make this list; surprisingly none of them have a Batting IMPACT of even 1. Nevertheless both of them have 1 SD each - not at all a common thing amongst wicket-keepers (except Adam Gilchrist and MS Dhoni).
These are the highest impact ODI batsmen in West Indies' history:
Perhaps the only big surprise here would be the presence of the West Indian opener Sherwin Campbell right at the end of this list - his relative consistency and singular SD getting him through here.
Viv Richards' superiority as a batsman is quite telling from this list, his Batting IMPACT of 3.12 is almost 26% better than the next batsman on this list. Moreover, he has the highest Batting IMPACT amongst all the batsmen in the history of ODI cricket. Also, his Strike Rate IMPACT of 0.37 is much higher than Chris Gayle's 0.12 (who is known for his big hitting) which just goes on to show the way Richards revolutionised and dominated the ODI format.
It is also interesting to note that Brian Lara is not the highest impact West Indian ODI batsman after Viv Richards as many expect him to be, even though Lara got more SDs than Greenidge and Haynes.
Ramnaresh Sarwan making this list ahead of Chris Gayle and Shivnarine Chanderpaul can be attributed to his remarkable consistency (2nd-lowest failure rate), ability to bat under pressure (2nd highest Pressure IMPACT) and success in chases (2nd-highest Chasing IMPACT).
It is also interesting to note that out of the 10 batsmen listed here, 4 of them are genuine all-rounders (Batting and Bowling IMPACT over 1) namely, Viv Richards, Clive Lloyd (though he did not bowl that often), Carl Hooper and Chris Gayle.
The stories that unfold on various batting parameters are revealing.
When it comes to Runs Tally IMPACT (proportion of match runs made through career), the highest impact batsmen are Gordon Greenidge, Vivian Richards and Desmond Haynes.
The highest Strike Rate IMPACT batsmen (highest strike rates relative to all the matches in their careers) are Vivian Richards, Clive Lloyd and Ricardo Powell.
The best Pressure IMPACT batsmen (those who absorbed the most pressure that came about due to fall of wickets) are Clive Lloyd, Ramnaresh Sarwan and Vivian Richards.
The batsmen with the highest Partnership Building IMPACT (who built the most partnerships in the middle) are Vivian Richards, Gordon Greenidge and Desmond Haynes.
The best Chasing IMPACT batsmen (who registered the highest impact while chasing a target) are Vivian Richards, Brian Lara and Ramnaresh Sarwan.
The batsmen with the lowest failure rates (a failure is seen in this system as an inability to register an IMPACT of even 1 in a match) are Gordon Greenidge, Ramnaresh Sarwan and Vivian Richards.
Do not miss the small detail of Vivian Richards being on every single one of these lists.
The Highest Impact Batting Performances in West Indies' ODI history:
1. RL Powell - 124 off 93 v India, Singapore, 1999 - Batting IMPACT 9.51
Chasing 255 in 50 overs in the Coca Cola final against India, West Indies collapsed to 67-4 in the 17th over when Ricardo Powell stepped in and played a whirlwind innings to take West Indies single-handedly to the title. He scored 68% of his runs in boundaries and decimated a comparatively weak Indian bowling attack.
2. IVA Richards - 138 not out off 157 v England, London, 1979 - Batting IMPACT 9.29
At a stage as big as the 1979 World Cup final, Viv Richards stepped in and rose to the occasion magnificently. Coming in when West Indies were under a bit of pressure at 22-1, he looked at ease and gave the West Indian innings a much needed momentum. However, wickets continued to fall around at him and soon the scorecard read 99-4 when he finally found an able ally in the form of Collis King. Both of them attacked the English bowling disdainfully and helped West Indies to a total of 286. In reply, England could muster up only 194 runs which eventually meant a second consecutive world title for West Indies - till now, their last.
3. BC Lara - 153 off 143 v Pakistan, Sharjah, 1993 - Batting IMPACT 7.93
Chasing 285 against Pakistan in this Champions Trophy final encounter, West Indies needed a good start to ensure that their chase was on course. Brian Lara made sure that he not only gave that start as opener but also continued West Indies' surge towards the championship till the very end. His flaying of the Pakistani attack, (which was a bit weakened by the absence of Aaqib Javed and Wasim Akram) saw him smacking 21 boundaries and by the time he was dismissed, West Indies were only 11 runs short of the target.
The above performances are all within the series/tournament context. The highest impact batting performance within a match context in West Indian ODI history is Vivian Richards' unbeaten knock of 189 off 170 against England in Manchester. Coming in to bat at 11-2, Richards scored 70% of his team's total runs. The highest score in the West Indian innings after him was 26. The entire English team in reply couldn't catch up with him and collapsed for 168. Vivian Richards' unbeaten 119 off 133 v England (Scarborough, 1976) and his unbeaten 153 off 130 v Australia (Melbourne, 1979) are the next highest impact innings within a match context.
These are the highest impact ODI bowlers in West Indies' history:
As expected, the list is made up of as many as 9 West Indian fast bowlers. The usual suspects for the most part, surely. The only all-rounder and the spinner on this list is Carl Hooper, who remarkably has made it to all the three lists.
Joel Garner and Michael Holding unsurprisingly head this list. The failure rates for both (23 and 26 respectively) are very low and show the exceptional level of consistency in their performances. The West Indian dominance in that period can be gauged by the fact that both of them used to bowl in tandem with the new ball. Their career Bowling IMPACT actually puts both of them amongst the four highest impact bowlers in ODI history.
Note: If we were to reduce minimum qualification for this list to 50 matches instead of 75, Andy Roberts (56 matches, 2.96) would be West Indies' highest impact bowler in its ODI history and the 4th highest impact bowler in ODI history.
These are the highest impact players in all bowling parameters.
When it comes to Top/Middle-order Wickets Tally IMPACT (wickets taken from nos. 1-7 in most cases), the highest impact bowlers are Joel Garner, Ian Bishop and Michael Holding.
Lower-order Wickets Tally IMPACT (batsmen nos. 8-11) - highest impact bowlers are Dwayne Bravo, Michael Holding and Ian Bishop.
The highest Economy IMPACT bowlers (lowest economy rates relative to all the matches in their careers) are Joel Garner, Curtly Ambrose and Michael Holding.
The highest impact Partnership-breaking bowlers are Dwayne Bravo, Chris Gayle and (interestingly) Phil Simmons.
The bowlers with the highest Pressure Building IMPACT (taking quick wickets to put opposition under pressure) are Michael Holding, Mervyn Dillon and Ian Bishop.
The bowlers with the lowest failure rate (a failure is seen in this system as an inability to register an IMPACT of even 1 in a match) are Joel Garner, Michael Holding and Curtly Ambrose.
The Highest Impact Bowling Performances in West Indies' ODI history:
Top 3 Bowling Innings (Series/tournament context):
1. J Garner - 5 for 31 in 10 overs v Australia, Melbourne, 1984 - Bowling IMPACT 6.92
In this third final of the Benson and Hedges World Series Cup, Australia were jolted early by the loss of Kepler Wessels and Allan Border and were tottering at 23-2 due to Garner's fiery brand of pace bowling. When he returned for his next spell, Australia had stabilised themselves to a score of 185-5 but the "Big Bird" KOd them again, as Australia collapsed to 212-8 in 50 overs. In reply, West Indies easily chased down the target with six wickets to spare.
2. MA Holding - 5 for 26 in 10 overs v Australia, Sydney, 1985 - Bowling IMPACT 6.68
If it was Garner who won them the World Championship series in 1983-84, Michael Holding made sure the trophy stayed with the West Indians in the 1984-85 series. In a devastating spell of fast bowling he tore open the Australian middle order. When Holding came in to bowl, Australia were 51-1, when he left they were reeling at 89-7. Needless to say West Indies wrapped up the chase with 7 wickets to spare.
3. BD Julien - 4 for 27 in 12 overs v New Zealand, London, 1975 - Bowling IMPACT 5.96
In this 1975 World Cup semi-final encounter, Bernard Julien crashed through the defences of the New Zealand batsmen who were busy adjusting against the speed and bounce of Andy Roberts. Caught unawares, New Zealand collapsed from a comfortable position of 125-4 to 139-7 and eventually could muster up only 158. In reply West Indies finished off the match with five wickets in hand and secured their passage to the final.
The above performances are all within the series/tournament context. The highest impact bowling performance within a match context in West Indies' ODI history is Colin Croft's 6-15 v England (St Vincent, 1981). Patrick Patterson's 6-29 v India (Nagpur, 1987) and Winston Davis' 7-51(Best bowling figures in ODI at that time) v Australia (Leeds, 1983) are the next highest impact bowling performances in a match context.
So, these are the highest impact players in West Indies' ODI history, seen through Impact Index. Not surprisingly, the "Fire in Babylon" West Indies much more prominent here than those from later teams.
For more information, please go to www.impactindexcricket.com


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Liposomal Daunorubicin in Treating Patients With HIV-Related Kaposi's Sarcoma
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Drugs used in chemotherapy, such as liposomal daunorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
PURPOSE: This clinical trial is studying how well liposomal daunorubicin works in treating patients with HIV-related Kaposi's sarcoma.
|Drug: liposomal daunorubicin citrate
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Pilot Study of Viral Load and Transcription in Kaposi's Sarcoma Patients Treated With Liposomal Anthracyclines
- Effect of liposomal daunorubicin citrate on Kaposi's sarcoma-associated herpes virus (KSHV) viral gene expression in tumors [ Time Frame: 24-48 hours after the first treatment ]
- Effect of treatment on KSHV viral gene expression in peripheral blood mononuclear cells [ Time Frame: 24-48 hours after treatment on Day 1/cycle 1, Day 8/cycle 1, and Day 29/cycle 3 ]
- Effect of treatment on KSHV viral load in plasma [ Time Frame: 24-48 hours after treatment on Day 1/cycle 1, Day 8/cycle 1, and Day 29/cycle 3 ]
|Study Start Date:
|September 2008
|Study Completion Date:
|November 2011
|Primary Completion Date:
|November 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: liposomal daunorubicin citrate
40 mg/m2 Days 1 and 15 every 28 days x 3 cycles
Drug: liposomal daunorubicin citrate
40 mg/m2 Days 1 and 15 every 28 days x 3 cycles
Other Name: DaunoXome
Detailed Description:
- Determine the effect of liposomal daunorubicin citrate on Kaposi's sarcoma-associated herpes virus (KSHV) viral gene expression in tumors of patients with HIV-related Kaposi's sarcoma.
- Determine the effect of this drug on KSHV viral gene expression in peripheral blood mononuclear cells.
- Determine the effect of this drug on KSHV viral load in plasma.
- Correlate viral load with viral gene expression and/or tumor regression in these patients.
OUTLINE: This is a multicenter, pilot study.
Patients receive liposomal daunorubicin citrate IV days 1 and 15. Treatment repeats every 4 weeks for at least 3 courses in the absence of disease progression or unacceptable toxicity.
Biopsies are performed at baseline and once during treatment to evaluate Kaposi's sarcoma- associated herpes virus (KSHV) viral gene expression in tumors and skin tissue using reverse transcriptase-quantitative polymerase chain reaction. Blood samples are collected at baseline and periodically during treatment to evaluate KSHV viral gene expression in peripheral blood mononuclear cells and viral load in plasma.
PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Histologically confirmed Kaposi's sarcoma (KS) involving the following:
- Skin
- Lymph nodes (palpable disease only)
- Oral cavity
- Must have ≥ 5 measurable, previously nonirradiated, cutaneous lesions that can be used as indicator lesions
- Must have 2 lesions ≥ 5 x 5 mm that are accessible for 4 mm punch biopsy
- Serologically confirmed HIV positivity
Concurrent antiretroviral therapy required, except for patients who have exhausted all available treatment options
- Must be on a stable dose for ≥ 4 weeks
- Life expectancy ≥ 3 months
- No other neoplasia requiring cytotoxic therapy
- Not pregnant or nursing
- Fertile patients must use effective barrier contraception during and for 3 months after completion of study treatment
- See Disease Characteristics
- No prior anthracycline therapy
At least 4 weeks since prior antineoplastic treatment for KS, including any of the following:
- Chemotherapy (6 weeks for nitrosoureas or mitomycin C)
- Radiotherapy
- Local therapy
- Biological therapy
- Investigational therapy
- At least 60 days since prior local therapy of any KS indicator lesion unless lesion has clearly progressed since treatment
- No other concurrent investigational drugs, cytotoxic chemotherapy, or KS-specific treatment
Please refer to this study by its ClinicalTrials.gov identifier: NCT00427414
|United States, Florida
|University of Miami Sylvester Comprehensive Cancer Center - Miami
|Miami, Florida, United States, 33136
|Instituto De Infectologia Emilio Ribas Hospital
|Cerqueira Cesar - Sao Paulo/SP, Brazil, 01246-900
|Centro de Referencia e Tratamento DST/AIDS
|Sao Paulo, Brazil, 04121000
|Study Chair:
|Juan Carlos Ramos, MD
|University of Miami Sylvester Comprehensive Cancer Center
|Study Chair:
|Dirk Dittmer, PhD
|UNC Lineberger Comprehensive Cancer Center
|Principal Investigator:
|Tamara Newman Lobato Souza
|Instituto De Infectologia Emilio Ribas Hospital
|Principal Investigator:
|Luis Carlos Pereira, MD
|Instituto De Infectologia Emilio Ribas Hospital
|Responsible Party:
|AIDS Malignancy Consortium
|ClinicalTrials.gov Identifier:
|NCT00427414 History of Changes
|Other Study ID Numbers:
U01CA070019 ( U.S. NIH Grant/Contract )
CDR0000526564 ( Other Identifier: NCI )
|Study First Received:
|January 25, 2007
|Last Updated:
|April 28, 2015
Keywords provided by AIDS Malignancy Consortium:
AIDS-related Kaposi sarcoma
recurrent Kaposi sarcoma
Additional relevant MeSH terms:
Sarcoma, Kaposi
Neoplasms, Connective and Soft Tissue
Neoplasms by Histologic Type
Herpesviridae Infections
DNA Virus Infections
Virus Diseases
Neoplasms, Vascular Tissue
Citric Acid
Calcium Chelating Agents
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action
Antibiotics, Antineoplastic
Antineoplastic Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


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Los Angeles has no shortage of romantic date night options. You could try hiking up to Griffith Observatory for a sunset snuggle; taking a spin on the Ferris wheel at the Santa Monica Pier; standing in line for hours to gorge yourself on hotdogs.
But sometimes the occasion calls for something simpler—a chance for you and your sweetie (or potential sweetie) to unwind and open up a bit. And nothing sets the mood for relaxation and stimulating conversation like a good drink. Whether you're looking for cocktails to spark conversation on a first date or for something to take the edge off after leaving the kids with a sitter, here are 6 of our favorite LA spots for a date night drink.
About the author: Katie Robbins is a writer based in Los Angeles. Her work has appeared in Saveur, O Magazine, Psychology Today, and Eating Well, among others. You can follow her on Twitter at @robbinskatie.


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My cousin Steve is a director/filmaker. He came across what could very well be the first DJ Mixer. The Gaumont Chronophone was designed for theater sure but it really makes you wonder if there is a time machine somewhere!
"In 1903 French engineer Leon Gaumont was granted patents for loudspeaker systems to go with his sound on disc talking films, which used one of Berliner's Gramophones. In 1910 Gaumont demonstrated his Chronophone system, which synchronised sound and film, at the Gaumont Palace in Paris. The compressed-air amplifier, whiuch he called the Eglephone, was just a part of the whole system. The volume was enough for an audience of 4000. Initially the longest moving picture that could be made with synchronised sound was only 200ft, due to the limited playing time of the Gramophone record. (Projection was at 16 frames per second) Gaumont surmounted this problem by having two gramophone platters; a deft operator could switch between them to give a more or less continuous soundtrack." – aqpl43.dsl.pipex.com
For more info: aqpl43.dsl.pipex.com/museum…
via Steve Monosson


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You are here: Kidspot Activity Corner Party games Sprinkler twister
Sprinkler twister
This is a wonderfully fun twist on a classic game that everyone loves to play! Stay cool while you twist and turn and try and keep your footing while getting soaked with the hose!
Number of players:
What you need:
- hose
- twister game
- water
Set up your game of Twister in the back garden.
Choose someone to be the water sprayer.
Give them the hose and turn on the water.
Play the game as usual but try keeping your footing with the added slippery surface caused by the water.
The winner is the last player to keep their balance.
- Add some detergent to make this a little more tricky for the older kids - or the adults.
Learning benefits of play, craft and activities:
- Benefits of crafts for kids
- Craft ideas to make for babies
- Why reading is important
- Your child's development milestones
- Why play makes kids smarter
- The importance of outdoor play
- Types of play
- How craft helps unplug kids from screentime


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Dotel still bothered by elbow inflammation
ANAHEIM -- When Tigers manager Jim Leyland left Phil Coke in to pitch a third inning of relief in the 13th and deciding inning Sunday, facing right-handed slugger Mark Trumbo, there was a reason. He didn't have his main right-handed specialist available.
Octavio Dotel is out once again with elbow inflammation, the same issue that sidelined him for a few days last week.
"The inflammation's still there," Dotel said. "It doesn't go away. We're just going to see how it will be on Tuesday."
The Tigers are off on Monday before beginning a nine-game homestand Tuesday night against the Royals.
Leyland did not comment on Dotel's status -- other than the fact that he wasn't available Sunday -- nor did he want to discuss the possibility of a roster move. The Tigers were able to handle the loss of Dotel last week by skipping Rick Porcello for a start and putting him in the bullpen. That's not much of an option this week; the best they could do is push his start back by a day.
Thus, if Dotel isn't available, the Tigers would either have to work with a short-handed bullpen or make a roster move to call up somebody.
Dotel downplayed the injury a bit, saying it isn't pain but swelling.
"I haven't gotten the swelling to go away," he said. "It's still there. I'm just trying to get through that, but it's still there and hopefully we just found out a way to get out."
Jason Beck is a reporter for MLB.com. Read Beck's Blog and follow him on Twitter @beckjason. This story was not subject to the approval of Major League Baseball or its clubs.


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Courtesy Monique Lhuillier; Courtesy Ralph&Russo
When it comes to Kate Middleton's wedding gown plans, fashion insiders from Savile Row to Seventh Avenue are abuzz with predictions—and opinions. "Any designer would love to design for a royal wedding," Elizabeth Emanuel, co-creator of Princess Diana's 1981 gown, told UK newspaper the
Daily Mail
. Adds London designer Suzanne Neville: "I would hope that she keeps British." Alas, it would seem that the weight of the fashion world rests on Kate's slim, likely-to-be-lace-covered shoulders. And while names from the obvious (her favorite designer, Daniella Issa Helayel) to the more obscure (English designer Phillipa Lepley) have been tossed around, it's still anybody's guess who will design the gown of the century. But that hasn't stopped designers from speculating—or sketching. "I think she will be covered, but in a modern way," says American designer Monique Lhuillier, whose Kate-inspired gown includes organza flowers on the shoulders and a grand skirt. "When I think of the royal family, it is important to keep the style of the gown classic, regal, opulent—and subtle."
UK designer Ben de Lisi, a frequent Oscars choice for Kate Winslet, designed a gown to suit Middleton's "long, pure, lean figure," describing his vision as "young, fresh, modern and understatedly grand." The common thread throughout every design? Chic restraint. "London girls…tend to be a little more classic and not show off their bodies so much," says Neville. "Kate has that 'London look.' I don't think she likes to be on display too much." And while she may be wearing Diana's engagement ring, her dress will be a departure, experts predict: "Diana's was all frill and flounce," Emanuel told the Daily Mail. "I imagine Kate will steer well clear of a big, bouffant dress." Either way, it's still going to be huge. –Suzanne Zuckerman; reporting by Monique Jessen, Kristen Mascia and Simon Perry


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Photos: Inside Mike Tyson's mansion
Northeast Ohio photographer Johnny Joo shares pictures from inside Mike Tyson's mansion in Southington, Ohio.
Sponsored by:
Northeast Ohio photographer Johnny Joo shares pictures from inside Mike Tyson's mansion in Southington, Ohio.
The world's oldest person, a Japanese woman, died Wednesday, a few weeks after celebrating her 117th birthday.
The request says the monitor will assess and report to the parties and U.S. District Court in Cleveland.
The 5th Floor restaurant is located inside the Commerce Building in the former Youngstown Club.
Braceville and Warren police are trying to sort out exactly what happened when a car crashed on Route 5 about 8:30 p.m. and gunshots were fi…
It wasn't immediately clear what illness she had.
WARREN, Ohio (WKBN) – Chase Bank is closing its main Warren branch at 106 E. Market St. downtown and will consolidate with its branch at 116…
Students should be focused on learning, not worried about paying for college, Michael Drake said during his formal installation ceremony.
Emergency workers took a 15-year-old suspect to the hospital, saying he was throwing up and appeared drunk.
Molina was convicted of third-degree murder and sentenced to 20 to 40 years but won a new trial based on a prosecutor's remarks.
In a chaotic scene, people hid in bathrooms at the Eye Medical Clinic and were seen climbing from the windows of the ground level building a…
While not legally binding, the policies likely will decrease the number of businesses willing to sell such lethal injection drugs to prison …
The car, which belongs to the Clay County Health Department, ended up in a ditch and sustained significant damage after being hit by the air…
In addition to the $25 million in actual damages, the lawsuits seek unspecified punitive damages and ask for a jury trial.
California Highway Patrol investigators were trying to determine why Vasquez was on the freeway, said Officer Chris Baldonado.
Authorities in Delaware County charged 27-year-old Tyaina Finch of Glenolden with first- and third-degree murder.
U.S. Route 422 in Warren will be widened and resurfaced as part of a $3.5 million project by the Ohio Department of Transportation.
Federal authorities say 45-year-old Mollie Parsons was recently indicted on four counts of health care fraud.
Judge Algenon Marbley has ordered attorneys from both sides to meet with him Wednesday afternoon.
Authorities say two people have been found dead in a Philadelphia-area residence.
A seven-member committee will review the proposals and make recommendations to the city's Board of Control.
The Ohio Department of Transportation said on Thursday, traffic likely will go down to one lane until the fall.
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With racing spirit and assertiveness, this short cowhide glove was designed to attack the road in the saddle of your bike, offering excellent ergonomics and protection, through patented Microelastic inserts and to ergonomics designed for sports riding. With carbon fibre composite inserts on the knuckles and fingers and construction of the little finger reinforced with TPU inserts, Carbon Cover ST is the choice for the most demanding sport tourers. This glove, also available in the lady's version, is completed by a goatskin palm, construction with a single panel of leather covering the seams on the edge of the hand, tightening strap and perforation on the inside of the fingers.
Technical features:
-Composite inserts in carbon fiber on knuckles and joints of the fingers (no Lady)
-Polyurethane insert on the joints of the fingers and palm (no Lady)
-Distortion Control on little finger (no Lady)
-TPU inserts on side of little finger
-Certified as PPE to EN 13594 Standard cat. II lev. 1
-Cowhide leather
-Palm in goatskin
-Kevlar® fiber stitching
-Spandura fabric
-Amica Suede leather reinforcement between thumb and index on the left hand
-Digital Suede leather reinforcement between thumb and index and fingertips of index and middle finger of right hand
-One single leather panel to the size of the hand
-Precurved fingers
-Microelastic elasticated inserts
-Elasticated inserts
-Adjustable cuff strap
-Tightening strap
-Perforation on inner side of fingers
-Soft inserts
-Cover on the tightening strap
-Microelastic (European patent pending)


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HOUSTON - Three HISD elementary schools won $25,000 grants from Target to help provide educational resources in the classroom.
Highland Heights, Atherton and Briscoe elementary schools were among the 100 schools nationwide selected to receive this grant.
The money will be used to purchase new technology, such as iPads. The grant will also be used to enrich current programs, and help fund after-school programs that help supplement classroom learning and engage kids safely.
"This grant could not have come at a more perfect time for these schools," said HISD Superintendent Terry Grier. "Amid the recent state budget cuts, teachers and administrators are faced with doing more with less as they continue to provide their students a rigorous education. There is no doubt that this grant will be put to great use at these schools," he continued.
Give With Target is a two-part giving campaign aimed at helping schools across the country by providing $2.5 million in grants to 100 in-need schools.
Copyright 2012 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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|Comments on Photo
|Add Comment
By markguycan
From: flagstaff, AZ
Nov 3, 2012
|I seriously doubt rockfall would cause both hangers to be so perfectly flattened. I suspect a crack climbing purist has enforced his ethics on everyone. It's unfortunate since this testpiece will be harder to back off from if it can not be finished for reason.
By 1Eric Rhicard
Nov 4, 2012
|If those are big fat Metolius "pig ears" I am guessing you would see hammer marks all over the edges if they had been smashed flat. I looked at the before and after pictures and that was a huge block. It would be way easier to just unscrew the bolts and take the hangers. Wow that is terrifying to think someone could have been killed like a bug underfoot.
By Mike
From: Phoenix
Nov 4, 2012
|It was definitely rockfall. There is rock scarring in the area, a giant swath of destruction below, and the old roof is simply gone.
By JJ Schlick
From: Flagstaff, AZ
Nov 4, 2012
|Looks like they were steam rolled.
By manuel rangel
From: Tempe, Arizona
Nov 5, 2012
|Definitely enough rock fell that it would have easily smashed the hangers flat. The chunks of rock scattered below the wall were huge.
By Sean C
From: SLC
Nov 5, 2012
|Did you climb the new variation Manuel?
By Cornelius Jefferson
Mar 12, 2013
"I suspect a crack climbing purist has enforced his ethics on everyone."
lol thats one way to put it
By Caitlin Mac
From: Tempe
Oct 18, 2013
|Do you guys know if there is a place to just build an anchor here?
By Robbie Brown
From: Flagstaff, AZ
Nov 17, 2013
|yeah the crack takes good gear, although i am a little suspicious of the rock after what happened...
|Avg Score
|5.0 from 1 votes
|Your Score


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Back in high school I had to borrow my neighbors car to run a few errands. As I picked up the car I asked him, "Is there anything I need to know?†He replied, "Keep your eye on the flow of traffic because the speedometer is broken.â€Â Being a new driver I didn't realize how big of a deal this was until I was heading down the road passing what felt like a million cops with no clue whether or not I was speeding.
It doesn't take a genius to realize that you need every gauge on your car's dashboard to head down the road safely. Without it you don't know how far and fast you are going. You need it to track the health of the cars and when you need a tune up.
In youth ministry you need a dashboard for similar reasons, because you need to know:
What Are You Tracking?
This might be a question that makes you nervous because it brings up the numbers game; however, it's more than that. Knowing what you are tracking means you are keeping track of the health of your ministry. Therefore, you need to be tracking:
Who Is Coming: Attendance is more than just a blank number, it can help us determine if we are tracking more boys than girls or more churched than unchurched. Tracking attendance isn't just counting bodies; it allows you to understand how you are growing. Knowing who is coming will also shape the identity of your ministry.
Spiritual Deepening: It's very difficult to judge a man's heart (unless you are God); however, by tracking spiritual deepening you are looking at the ratios of teens that are showing up versus how many are going deeper. Knowing the ratios means knowing that teens might struggle to plug into a ministry versus a small group. This helps you understand the path you've laid out for them in your ministry.
Why Teens Are Coming: Tracking this question may lead to answers as simple as, "My friend brought me.†Or "My mom made me.†however, it will also show you your influence and impact in the community. Do people know about you? How are they learning about you? Are you more present in certain schools, clubs or teams? Know this and you can make your impact greater.
Adult Influence: Tracking ministers might not be a difficult task because you work at a small church or there aren't a lot of adults serving in the student ministry. However, if you don't track who is serving, how long they are staying, why they are leaving and how they got into ministry then you are never going to learn how to grow the number of men and women serving in your ministry.
Budget: If you want to protect or increase your budget you need to know where the money is going and even where it's coming from. Finances are definitely not the most appealing area of student ministry; however, it's important. Without God honoring stewardship it's going to be hard to fund the movement you are trying to lead.
Whether you use certain software or a basic spreadsheet you need to be tracking the progress, growth and movement of your ministry. With no dashboard you are essentially putting your ministry at risk of crashing and spinning out of control. Talk to your leaders and take the time to answer the question, "What should I be tracking?â€
What other aspects of ministry should we be tracking?
Chris Wesley is the Director of Student Ministry at Church of the Nativity in Timonium, MD. You can read more about his blog Marathon Youth Ministry.


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Named after her eldest son, Luca is the label of Laura Catena, the Huffington Post guest blogger, Harvard graduate (with a Medical degree from Stanford), and, of course, daughter of Nicolas Catena. From vineyards in Mendoza (Lujan de Cuyo and Agrelo) and Uco Valley, winemaker Luis Reginato produces concentrated, classy Syrah, Pinot Noir, Malbec and Chardonnay, each bearing supple, fleshy textures and superb sweetness of fruit. The flagship Beso de Dante is a blend of Cabernet and Malbec. Catena's Chardonnay offers exotic but vibrant aromas and flavors of apricot and soft citrus fruits, with judicious use of new oak. These wines are serious but utterly quaffable; it's no surprise Luca is so well regarded by both critics and the public and has developed a passionate following, particularly in Argentina, Brazil, and northern Europe.
Until the early 1990s, Argentina's wine industry was focused inward, as the local market's thirst was sufficient to absorb the huge quantities of everyday drinking wine produced there. But with per-capita consumption in the domestic market in sharp decline since the mid-1970s, Argentina's wine producers realized that they had to look to export markets to remain in business, and winemaking in Argentina began its transformation.
In just a few short years, Argentina has shifted its emphasis to the production of quality wine and turned its attention to export markets. Vine yields have been reduced dramatically. Large old wood casks have been widely replaced by oak barriques. And a major wave of new planting has taken place in mostly cooler, high-altitude sites that are better suited to producing serious wines, such as the Uco Valley, in the foothills of the Andes, about 80 miles south of the city of Mendoza. Despite the widespread reduction of vine yields, Argentina remains a huge wine producer, ranking number five in the world. Red Argentine wines, especially those from Malbec, Cabernet Sauvignon, and blends incorporating these two varieties, represent the lion's share of the best bottles.
Many of today's finest Argentine wines have barely five years of history. Consulting winemakers from California and Europe have brought their technical expertise to Argentina, as well as their knowledge of what is necessary to compete in the world wine market. At the same time, there has been an explosion of foreign investment by wealthy wine producers, luxury corporations and individual investors attracted by inexpensive vineyard land and by Argentina's warm, dry climate. Since the Argentine peso was sharply devalued in late 2001, land prices have been even more attractive to outside investors.
The best Chardonnays in the world continue to arrive from the region where the grape first emerged: the chalk, clay, and limestone vineyards of Burgundy and Chablis. While the origins of the grape were disputed for many years, with some speculating that the grape came all the way from the Middle East, DNA researchers at the University of ~California Davis proved in 1999 that Chardonnay actually developed, most likely, in eastern France, as a cross between a member of the "Pinot" family and an ancient, and nearly extinct variety called Gouais Blanc.
Wine lovers who have come to think of Chardonnay as weighty and thick will find Chablis a revelation. When grown in the cool, clay-and-chalk soils around the sleepy town of Chablis, at the northern reach of Burgundy, Chardonnay is transformed into one of the world's most cerebral and distinctive white wines. With its brisk citrus character, floral lift, and incisive minerality, Chablis is at once sharper and more delicate than white Burgundy from the Cote d'Or nearly 100 miles to the southeast -- and potentially at least as long-lived. And Chablis is about as far removed from fruit and oak-driven New World Chardonnay as a white wine can be.
As recently as fifteen years ago, the American market had an unquenchable thirst for Chardonnay, particularly for examples from California. Today, although Chardonnay is still the most widely planted variety in California in terms of acreage, serious wine aficionados rarely talk about Chardonnays other than those from a handful of specialist producers. Even at the level of the mass market, many consumers have tired of overly alcoholic, over-oaked, and clumsy wines, not to mention neutral, technically correct but soulless examples. Many wine drinkers have moved on to fresher, less oak-influenced white wines such as Sauvignon Blanc. This is a shame, as the trend has turned toward brighter, better-balanced Chardonnays from cooler sites, with crisper fruit aromas, more soil character, and less reliance on new barrels for flavor.
Still, it's a two tier market. A relative handful of producers make wonderfully layered, complex Chardonnays that can easily hold their own against more expensive white Burgundies, at least in their early years in bottle. These wines, which can be richer than dry whites have any right to be, are among the most impressive wines made in California today and continue to be hotly pursued by collectors. The rest of California's Chardonnay producers compete for the attention of consumers who are no longer obsessed with this grape.
But there are now many excellent choices available, many from cooler areas. Lower elevations of Napa Valley have virtually been abandoned as appropriate sites for Chardonnay. Now the best wines come from the Russian River Valley and further west in Sonoma County; Carneros, the Anderson Valley to the north; and the Central Coast, especially the windy western portion of Santa Barbara County. Today, there are fewer blowsy, tropical-fruity Chardonnays with the alcohol levels and flavors of a pina colada and many more wines with fresher stone and citrus fruit elements, mineral notes, and restrained oak spice.
While most California Chardonnays should be consumed within two or three years of their release, the top examples can give pleasure for four to eight years, although it is debatable whether these wines gain more in texture and complexity than they lose in early fruitiness.
Just north of California, Chardonnay is by a wide margin Washington's most popular white variety in terms of vineyard acreage, yet the number of truly concentrated and consistently excellent wines is limited. Some of the most interesting Chardonnays come from the cooler Columbia Gorge viticultural area, which spills over into Oregon: the Celio vineyard in particular is the source of some very fresh wines that often show a juicy nectarine component.
On the other side of the world, the export market for Australian Chardonnay was driven in the 1980s by what is called the Show Reserve style -- attention-getting wines made for competitive tastings, usually marked by lavish oak spice, superripe tropical flavors, thick textures due to high alcohol, and sometimes even a bit of residual sugar to seduce early tasters. These wines can be difficult to take, either at the table or on their own. For better or worse, though, this is the style that defines Australian Chardonnay for many North American wine lovers. Fortunately, many producers have adjusted their wine-making regimens to make fresher, more vibrant, and energetic Chardonnays. The most obvious strategy has been to plant Chardonnay in regions and in microclimates better suited to making elegant wines with real flavor intensity than those with brute strength. Western Australia, particularly the Margaret River region, has emerged as a top growing area for Chardonnay, with superb wines also being produced in Victoria and the Adelaide Hills. Tasmania is showing promise as well.
Even if it is the country's second most important variety in terms of production, Chardonnay in New Zealand is of limited interest to international markets. Few sites appear capable of producing truly distinctive Chardonnay wines, and full crop levels and a high percentage of young vines further limit the grower's ability to transmit soil character into the bottle. Some wineries slap a lot of oak on their Chardonnays, with the result that the wines can be more about wood than about the variety. But fresh, unoaked Chardonnays made in a Sauvignon style have attracted a following in North America, especially where prices are reasonable.
2008 had 7 regions scored 95 or above. Paso Robles and Champagne, both got the highest score, with a 98.
Other regions that scored 95 points or higher were Napa, Oregon, Pomerol, Germany, and Washington.
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Southern California shoppers swarmed local stores Friday in search of Black Friday discounts on everything from iPads and smartphones to clothing and jewelry.
In an effort to snag consumers early, many retailers launched their Black Friday sales late Thursday.
Will they get the financial boost they're looking for?
If Wal-Mart's customer turnout is any indication, the answer is probably yes. On Friday, Wal-Mart U.S. reported that this looks to be its best ever Black Friday event.
During the high traffic period from 8 p.m. through midnight Thursday, the mega-retailer processed nearly 10 million transactions and nearly 5,000 items per second.
Bill Simon, Wal-Mart U.S. president and CEO, said that activity was fueled by savvy marketing and careful preparation.
Business also exceeded expectations Friday at the Best Buy mobile store in the Westfield Topanga mall in Canoga Park, which primarily sells tablets and smartphones.
"We're busier than I was expecting," said Ricky Panh, who was helping man the store. "We're about three times as busy as we were last year. I think that's probably because we were open at midnight."
Black Friday appeared to be a success for the Big 5 store in San Dimas.
"It's busier than I expected," store manager Jose Martinez said, adding that one of the store's early-morning customers asked to purchase two bicycles for $99 each.
Martinez said he was looking forward to brisk business in the hours ahead.
"It should stay steady through the day," he said.
The Black Friday "creep" of launching sales earlier began in earnest a few years ago when stores realized that sales alone weren't enough to lure shoppers anymore, especially with Americans becoming more comfortable buying things online.
But opening on Thanksgiving was risky, with some employees and shoppers complaining it was almost sacrilegious.
Still, many stores felt they needed an edge, especially this season, when many Americans are worried about high unemployment and wondering whether Congress will be able to head off tax increases and spending cuts before the U.S. reaches the "fiscal cliff" in January.
The National Retail Federation estimates that sales in November and December will rise 4.1 percent this year to $586.1 billion, falling below last year's gain of 5.6 percent.
There's no doubt that consumers have been inundated with Black Friday sales promotions. But Michael Carney, an economist at Cal Poly Pomona, isn't so sure the deals are always there.
"I've heard suggestions that the deals may not be what they have been in the past, he said. "In some cases, I've heard that something they say is on sale was actually selling for less a month or two earlier."
That may be true, but consumers were still out in force on Black Friday.
Parking spaces were at a premium Friday morning at local malls as bargain hunters looked for deals on the year's busiest shopping day.
Drivers went round and round at The Quad and Whittwood Town Center in Whittier and at the Pico Rivera Towne Center.
"I do it every year," Whittier resident LeeAnn Sandoval said.
She admitted, however, that she was out later than her usual pre-dawn shopping spree. Instead of lining up to shop on Thanksgiving, Sandoval chose to spend the holiday with her family.
"I don't think it was worth it to save a couple hundred dollars on a TV instead of being with my family," she said.
Staff writers Brian Day, Sandra Molina and the Associated Press contributed to this report.
626-962-8811, ext. 2701


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A BOLTON artist achieved his dream of 16 years when he launched his new exhibition of landscape paintings last night at Bolton Museum and Art Gallery.
James Naughton, who followed in the footsteps of Bolton-born 19th century artist Thomas Moran by embarking on a journey across the American West, was at Bolton Museum to unveil his exhibition, entitled 'Naughton and Moran: Paintings of the American West'.
Mr Naughton first became aware of Moran in 1998 and cites him as a major influence on his work.
With photographer and friend Andrew Hodgson, Mr Naughton visited the sites of Moran's most iconic works in Yellowstone National Park and the Grand Teton range in the Grand Teton National Park.
The pair ended their two-week trip — which they undertook last summer in a cramped all-American "RV" motorhome — at Green River, South Wyoming, the location of that first Moran painting Mr Naughton had seen as a young artist.
The exhibition took Mr Naughton, aged 42, from Heaton, nine months to complete and contains more than fifty paintings, all of which he completed from memory after travelling to the states of Utah, Wyoming, Idaho and Montana.
He said: "It's a privilege to bring my work and my experiences to Bolton, because this is my home town.
"It was an incredible experience going to America. What struck me was the scale of the landscape out there — there are so many wide open spaces. It's a massive expanse of space like you've never seen before.
"Thomas Moran is very inspirational to me. I was fascinated by his work from the moment I saw it."
More than 100 people attended the launch on Thursday. Opening the exhibition, the Mayor of Bolton Cllr Colin Shaw said he hoped Mr Naughton's work would inspire young Bolton artists in the same way Thomas Moran's work had inspired Mr Naughton.
The exhibition is open to the public from tomorrow, Saturday, March 1, and will run until November 16.


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Hope is that quality that sustains against hopelessness; a light in the darkness.
Mesothelioma is regarded as one of the most aggressive forms of cancer. It affects linings of body cavities and tissues surrounding certain organs. Most commonly affected is the pleural cavity, although the abdominal cavity can be affected, and more rarely the heart or testicular linings. Awareness of the connection between asbestos and lung disease grew in the first half of the 20th century, and exposure to asbestos was confirmed as the primary cause of mesothelioma in the 1950's. While treatment options have increased, and prognosis depends on several factors, average life expectancy was still only 10-11 months after diagnosis in 2010.
The author Neale Donald Walsh, in his book Conversations with God posits that the most powerful creative tool we will ever have is our own process of thought. In the book, Alcoholics Anonymous the authors identify themselves : " more than 100 men and women who have recovered from a seemingly hopeless state of mind and body." The singer/songwriter Warren Zevon, diagnosed with mesothelioma and given bare months to live in 2002, is sustained by no treatment but only his need to complete a last work and see his grandchildren born and succumbs a year and three months later. James "Rhio" O'Connor was given weeks to live after a diagnosis of mesothelioma in 2001. He committed to several alternative treatments and intensive lifestyle changes. In particular, he educated himself and designed a diet with the intent of surviving his cancer. He lived for 7 years, helping to lay out a path that would continue to give others hope. It often seems that medical miracles are defined by our inability to define the human spirit. More and more patients insist, as Mr. O'Connor did, on pursuing other avenues. Mr. O'Connor was part of a generational shift, still ongoing, as the medical community recognizes more and more that capitalizing on that indefinable spirit can be a powerful therapeutic tool. Mr. O'Connor wrote a book (They Gave Me Months, I Took Years) on making, researching, and implementing his decision. Partly as a result, finding effective alternatives is a much simpler prospect today.
Hope:n: desire accompanied by expectation Webster's New World Dictionary
We are in the midst of a generational shift in our thinking. Finding a solution to the health care crisis in America will be driven by our demand for effective treatments as much as by the ability of medical science to deliver those treatments. The simple facts are these – Patients choose to employ conventional treatments- radiation, surgery, chemotherapy, and pharmacology among others – because they are effective. Patients choose to employ alternative therapies – mind/body therapies, nutritional therapy, energy therapies like Reiki for instance, because they are also effective. Mr. O'Connor is one of a growing number of patients who have chosen alternative treatments as their primary therapies. The perception of the FDA as a trusted source for safety information has been eroded by a history of false starts (Celebrex and Vioxx, not to mention Thalidomide) and some see it as a shill for pharmaceutical companies. Thus, the lack of FDA approval for some alternative therapies does not deter people as it may have a generation ago. Many respected organizations, hospitals, and schools now provide a wealth of information. Cancer Monthly ( http://www.cancermonthly.com) is an organization closely allied with Mr. O'Connor's legacy, helping patients make informed decisions about their care. The University of Texas' MD Anderson Cancer Center (http://www.mdanderson.org/education-and-research/resources-for-professionals/clinical-tools-and-resources/cimer/index.html) is a wealth of information and active research into alternative and complementary therapies, as well as providing training for oncology professionals.
Hope n: grounds for believing that something good may happen Oxford English Dictionary
Despite this progress, despite growing research efforts, conventional medicine often mentions the use of alternative/complementary therapies with disclaimers. Practitioners of alternative treatment methods refer to themselves as healers. Movement in thinking will take place, as it must, from both perspectives. Paul Kraus, in his book Surviving Mesothelioma and other Cancers ; a Patient's Guide (http://www.survivingmesothelioma.com )expresses the view of traditional western cancer therapies as palliative because he sees the focus as being relief of symptoms rather than treating root causes. Remember this is a patient's perspective but he is not alone in seeing the doctor/patient relationship in adversarial terms. We as a society must find that common ground where complementary providers are not automatically seen as charlatans, nor do we resist medical guidance, our physicians regarded as out of touch with regular folk. This shifting process is already underway. Even when results are inconclusive, as in efforts to understand the potential role of an antioxidant-rich diet in cancer prevention, the focus on seeking answers by addressing lifestyle is promising. A large body of research shows that meditation and meditative activities are very helpful. Looking to the future, as we meld the power of medicine with the power of the human spirit, it will become common for cancer patients to receive information, direction, counseling and help in applying these therapies in addition to all the best medical and pharmacological treatment available. Based on the experience of Mr. O'Connor and a growing legion of others, we will help increase not only patients' chances of surviving cancer, but the quality of their life in survival.
Robert Cleaveland is a Sophomore at the University of New England


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Alaska Village Grapples With Collapse in Walrus Harvest
Residents rush to find alternate sources of food before winter
GAMBELL, Alaska—For as long as many here can remember, hunters in this Eskimo village where the mountains of Siberia are clearly visible have managed to kill enough walruses to provide food that lasts through the brutal Arctic winter.
But after harvesting only 108 walruses this year—one sixth the average—the island community of 690 residents is rushing to find alternate sources of food before winter sets in. Other towns have offered donations of reindeer and fish, but tribal officials say it isn't enough to offset the...