text:
Study in Healthy Males to Measure Darunavir and Etravirine in Blood, Seminal Fluid, and Rectal Tissue (DESeRT)
This study has been completed.
University of North Carolina, Chapel Hill
Tibotec Pharmaceutical Limited
Information provided by:
University of North Carolina, Chapel Hill
ClinicalTrials.gov Identifier:
First received: March 2, 2009
Last updated: May 11, 2011
Last verified: May 2011
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study is being conducted to look at how the body handles the drugs darunavir and etravirine. It will measure the amount of darunavir and etravirine in blood, semen, and in the rectum of men. The aim is to understand how much of the drug (taken by mouth) reaches the reproductive and intestinal tracts. It is believed that the presence of this drug in these areas may be beneficial in preventing the AIDS virus (HIV) from being passed from one person to another. The study will take samples of blood, semen and rectal mucosal tissue to measure drug levels. This study will also collect information on side effects.
|HIV/AIDS HIV Infections
|Drug: darunavir Drug: Ritonavir Drug: Etravirine
|Phase 1
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
|Official Title:
|A Phase IV, Open Label Study in Healthy Male Subjects to Investigate the Extent of Darunavir/Ritonavir and Etravirine Exposure in Blood, Seminal Fluid, and Rectal Mucosal Tissue Following Single and Multiple Dosing of Darunavir/Ritonavir and Etravirine
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Ritonavir Darunavir Etravirine Darunavir ethanolateU.S. FDA Resources
Further study details as provided by University of North Carolina, Chapel Hill:
Primary Outcome Measures:
- To generate individual pharmacokinetic parameters for darunavir, ritonavir, and etravirine in seminal plasma after single and multiple dosing [ Time Frame: Study days 1, 7, and 8 ]
- To generate composite pharmacokinetic parameters for darunavir, ritonavir, and etravirine in rectal tissue after single and multiple dosing [ Time Frame: Study days 1 and 7 or 8 ]
Secondary Outcome Measures:
- To generate matrix:blood plasma ratios of darunavir, ritonavir, and etravirine in semen and rectal tissue after single and multiple dosing [ Time Frame: Study days 1, 7 and 8 ]
|Study Start Date:
|July 2009
|Study Completion Date:
|February 2011
|Primary Completion Date:
|February 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Darunavir, ritonavir, etravirine
Single arm trial looking at the pharmacokinetics of darunavir, ritonavir, etravirine in healthy volunteers.
Drug: darunavir
Healthy male volunteers will take darunavir 600 mg orally twice daily for 15 doses (8 days)
Other Name: PrezistaDrug: Ritonavir
Healthy male volunteers will take ritonavir 100 mg orally twice daily for 15 doses (8 days)
Other Name: NorvirDrug: Etravirine
Healthy male volunteers will take etravirine 200 mg orally twice daily for 15 doses (8 days)
Other Name: Intelence
|Ages Eligible for Study:
|18 Years to 49 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Healthy male subjects between the ages of 18 and 49 years, inclusive, with intact genital tract and gastrointestinal tract. (Healthy is defined as no clinically relevant abnormalities identified by a detailed medical history, full physical examination, including blood pressure and pulse rate measurement, 12-lead ECG for individuals >35yo and clinical laboratory tests).
- Body Mass Index (BMI) of approximately 18 to 30 kg/m2; and a total body weight >/=50 kg (110 lbs).
- Evidence of a personally signed and dated informed consent document indicating that the subject has been informed of all pertinent aspects of the trial.
- Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other trial procedures.
Exclusion Criteria:
- Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).
- Subjects with a history of having a gastrectomy, colostomy, ileostomy, or any other procedure altering the gastrointestinal tract.
- Subjects with inflammatory bowel diseases (ulcerative colitis or Crohn's disease) and have a clearly defined diagnosis of irritable bowel syndrome.
- Subject who is unwilling to refrain from any sexual activity including intercourse and masturbation for 72 hours prior study visit Day 1 and until discharge from the study.
- Subject who is unwilling to refrain from rectal insertion of medical/recreation devices and products and from receptive anal intercourse, for 72 hours before study visit Day -1 and through 7 days after the last biopsy unless instructed otherwise by the investigators.
- History of febrile illness within 5 days prior to the first dose.
- Any condition possibly affecting drug absorption (eg, gastrectomy).
- A positive urine drug screen.
- A positive result for HIV.
- Active hepatitis B infection as defined by a positive Hepatitis B surface antigen (HbsAg) OR a positive Hepatitis B core antibody with a negative Hepatitis B surface antibody (HBsAb).
- Active hepatitis C infection as defined by anti-hepatitis C virus serology (as determined by multi-antigen EIA) and detectable HCV RNA.
- A positive test for syphilis, gonorrhea, Chlamydia, HSV-2 (active lesions) or trichomonas at screening.
- History of regular alcohol consumption exceeding 14 drinks (1 drink = 5 ounces (150 mL) of wine or 12 ounces (360 mL) of beer or 1.5 ounces (45 mL) of spirits) per week.
- Participation in a clinical study within 4 months preceding the first dose of trial medication.
- Participation in a rectal biopsy study in the 12 months preceding the first dose of trial medication.
- Use of prescription or nonprescription drugs, vitamins and dietary supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of trial medication. Herbal supplements must be discontinued 14 days prior to the first dose of trial medication. As an exception, acetaminophen may be used at doses of </= 1 g/day
- Blood donation of approximately 1 pint (500 mL) within 56 days prior to dosing.
- History of sensitivity to heparin or heparin-induced thrombocytopenia.
- Unwilling to abstain from alcohol use from 24 hours prior to the first dose of study medication until after the follow-up visit.
- Unwilling to abstain from cigarette smoking completely during inpatient pharmacokinetic visits and unwilling to limit smoking to a maximum of 5 cigarettes per day from 24 hours prior to the start of the study until study completion.
- Unwilling or unable to comply with the dietary restrictions in regard to study drug administration
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00855088
Please refer to this study by its ClinicalTrials.gov identifier: NCT00855088
|United States, North Carolina
|UNC Hospitals CTRC
|Chapel Hill, North Carolina, United States, 27514
Sponsors and Collaborators
University of North Carolina, Chapel Hill
Tibotec Pharmaceutical Limited
|Principal Investigator:
|Angela DM Kashuba, PharmD
|UNC Eshelman School of Pharmacy
|Principal Investigator:
|Kristine B Patterson, MD
|University of North Carolina, Chapel Hill
More Information
Keywords provided by University of North Carolina, Chapel Hill:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Angela Kashuba, PharmD, UNC Chapel Hill Eshelman School of Pharmacy
|ClinicalTrials.gov Identifier:
|NCT00855088 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 2, 2009
|Last Updated:
|May 11, 2011
Keywords provided by University of North Carolina, Chapel Hill:
HIV seronegativity
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


text:
2012 Ethnic Keepers Membership, Gold Disk
CHOKING HAZARD -- Small parts.
Not for children under 3 yrs.
Your Comments!
I would like to write this message to the whole Zakula family. I wanted to say thank you to all of you!! It is so nice to use books for my children and not be afraid of what they might read. Especially for our school books, and subjects like science and history. The Keepers and Contenders books are so wonderful in leading our kids to grow how God would want them to grow and someday have their own families. Service is wonderful with KOF and everything you stand for. So again, to ALL of the Zakula family, THANK YOU!! Teresa

subset: commoncrawl


text:
Call for an appointment
We are looking for very special people who truly care about these animals, not as property but as friends who will become a part of their adoptive families. Our priority is to make sure that the cats will never again need to be rescued. In order to accomplish this goal, we ask all potential parents to fill out a detailed adoption application. Adoption from CAT TALES means that you will be asked to make a tax deductible adoption donation and to pay for spay/neuter if it has not been done before you adopt. We also ask that the adopter agrees to follow-up visits from someone at CAT TALES. We want to do everything possible to make sure that the animals we place find the best possible homes and safest futures once released from our care.
Thank You!
Your message has been sent to Cat Tales, Inc.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


text:
Version 1.5 Upgrades:
Empire Vanquish Paintball Gun - Tuxedo Black is the latest paintball gun from Empire. The vanquish WILL change the game forever. Check out all the features of the Vanquish paintball gun.
Vanquish Vanquish Handware
Soft Features:
Feel free to contact our customer service with any questions or concerns regarding your order at:
Terms & Conditions - Privacy Policy - Shipping Policy - Site Map
Payment methods accepted:
Copyright Punishers Paintball Supply © 2003-2016 All Rights Reserved
All photography and text on this site is the original work of Punishers Paintball Supply and manufacturers.
Contents may not be used for any commercial or non-commercial purpose without prior written consent from www.punisherspb.com.


text:
On April 15, President Obama promised to pursue immigration reform if re-elected.
"I can promise that I will try to do it in the first year of my second term," he told the Spanish-language TV network Univision.
Haven't we heard that before? In June 2009, President Obama pledged to push for immigration reform, tapping a top Cabinet official to work with Congress and make it a priority.
Back then, he didn't have the excuse of blaming Congress for any inaction on the issue. Both houses of Congress were controlled by Democrats at the time.
In November 2009, in a speech at the Center for American Progress, U.S. Homeland Secretary Janet Napolitano said immigration reform would be a priority of the Obama Administration in 2010.
Two and a half years later, we are still waiting for meaningful reform.
Dairy farms continue to operate in legal limbo.
In February, while attending the World Ag Expo in California, I heard an incredible story about a Michigan dairy farmer who had three immigration raids occur at his place. The last time, law enforcement came in with a helicopter and tank, he said. The raids, along with being put on probation and fined $2.7 million for hiring illegal immigrant workers, left the farmer in a tough spot. He realized he had to start hiring Anglos, and that proved daunting just trying to find enough Anglo workers to stick around and do the work.
The fact of the matter is, very few American-born workers are willing to do the hard, physical work associated with dairying. If it weren't for immigrant workers, many dairies would be in major trouble.
Cows need to be milked; consumers need a reliable supply of dairy products, and billions of dollars flow through state and local economies because of it.
It's time that the government came up with some sort of clarity on this issue.
It's time someone stepped up and took a leadership role.
Addendum: I realize both political parties are at fault. Nothing meaningful got done during the Bush Administration on the subject of immigration reform. The editorial that appears here originally appeared in our online newsletter, Dairy Herd Network — and a number of people commented. I had to agree with a comment by "Stewart" from New York, who wrote:
"What is the point in delaying and not wanting to fix a problem? Both parties are fake when it comes to getting anything sensible done. To have such a major issue and only talk, talk and talk about it, and do nothing, makes absolutely no sense to the well-being of our country. If any reform is required, we must first start with the Senate and Congress… None of the blokes in DC feel any of it because they are so far away from the reality of things."
It's not a scientific sample, but on May 11 we asked readers of the Dairy Herd Network newsletter whether Obama or the presumptive Republican nominee Mitt Romney would be the most aggressive in pursuing immigration reform, if elected this November. Of the 106 people who voted, 59 percent said it would be Romney, 25 percent Obama, and 16 percent weren't sure.


text:
We have very nice follow-through to Friday's strong action. This action is a good example of how you don't need to buy into the teeth of a decline to catch a good trade. There was plenty of time Friday to take positions after the positive news. The anticipatory bulls, who have been buying all the way down, are now back to where they were last Wednesday morning and are probably happy to be cutting losses.
The question is whether this bounce can be built in. There isn't much choice but to take profits if you came into the day with longs, but these bounce can often last longer than you expect as underinvested bulls try to find buys and the bears are squeezed. Usually we don't see a gap like this immediately reverse. There will be quick flips and then another try higher when those left out try to jump in.
I've been a net seller this morning and sold down Apple (AAPL), ProShares Ultra S&P 500 (SSO) and a number of other positions. If it continues to hold up, I'll start inching in to a few other things that have good charts like Big Five Sporting Goods (BGFV), but I'd rather lock in gains and then buy higher if it looks like we will see sustained momentum.


text:
NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Saturday, September 23, 2017
Domestic Violence
Should I Speak Out About My Abuse?
I am a graduate student at a university. The department I belong to is a relatively small one. My ex-partner was also a grad student in the same department, and has since graduated and moved on to Doctoral studies at another university. I believe he maintains contact with several of our professors on a personal level. Due to the fact that his girlfriend (previous to me) committed suicide, he became something of a "department darling"; he has the good will and support of all the faculty, and I know that they have pulled many strings on his behalf. What they don`t know is that for the duration of his relationship with me (which lasted over two years) he abused me sexually, emotionally, psychologically, and physically. When he couldn't abuse me, he abused my little dog in order to hurt me (I think he may have been jealous of my love for her, as crazy as that sounds).
During those years I had a mental breakdown; I had always struggled with episodes of mild depression and anxiety, but since then I've been a mess. I completely lost my sense of self (at that point, if asked, I could not even have told you what my favorite color was; even my own name sounded strange to me). I did not receive much help other than prescription medications, as I was able to keep my breakdown fairly quiet and did not tell anyone the real reason for it, though my depression worsened to the point of constant suicidal thoughts. Over time I was able to pull the pieces of myself together somewhat, though I am a very different person today than the person I was before my breakdown. Not even my family knows the extent of what happened during those years. I am currently on a medical leave from my studies; I told my professors and the department head that I required it due to my struggle with depression and anxiety disorders, and that I would undergo an unrelated surgery during my leave (which I have).
I tried (unsuccessfully) to leave my partner several times. Things became especially difficult when he moved into the same apartment building as me – right across the hall, in fact. When I tried to leave him again, he was able to stalk me relentlessly and harassed me through phone calls and showing up at my door constantly. When the opportunity came to move with my family to a different state, I seized it. I didn't tell him I was leaving until a week or two before the move (I couldn't hide the packed boxes) and I arranged with my advisor and my department to continue my studies from afar (I had finished all of my course work, and only have to finish writing my thesis). My department didn't get a very good explanation of why I was moving away, but they didn't give me any trouble. I did hear that one of my professors told a friend that he didn't believe I would finish my course of study after moving.
Even after the move, my ex followed me to my new place of residence as it was en-route to the university where he is doing his doctoral studies. He stayed in town for one night and spent it trying to convince me to rethink things and to re-enter a relationship with him. I held firm and his attempts were somewhat foiled by the fact that my family was around for most of the time. I was very glad to see him go. I have since then cut off all contact with him and have not responded to his emails, phone calls, letters, and the gifts he's sent (it's now been over a year).
As my medical leave draws to a close, I am still struggling with depression and anxiety, although living with my family helps me to remain optimistic. I still have a very hard time dealing with what happened to me, and I feel an urge to speak out; I don't want to feel like a victim anymore. I know that my ex would never admit to any of it if he was asked. None of my friends know about the abuse that took place, because they were all his friends before they were my friends. And none of my professors know, because they were all his friends and mentors before they were mine. I am afraid to speak out because I am afraid that I will alienate them, that they won't believe me. If I tell the truth, will the people who consider him a successful "son of the department" think I am lying or more than a little mentally ill? If I tell my professors and they don't believe me, will it have an adverse effect on whether or not they pass my thesis?
I am desperate for advice, but have absolutely no one to talk to. Any help from an expert would be so greatly appreciated.
Thank you.
Thanks so much for sharing your story with me. I cannot tell you what to do, but I will state that given the circumstances of your encounter with this individual, it would be in your best interest and the interest of others to inform the public of his behavior. He has been a threat to your safety, and while there are no consequences for his behavior, others are at risk, as well. As you indicated in your story, he terrorized you for so many years, and you are now at a point where you want to reclaim your power and to no longer be a victim. I think speaking out and informing others is one way of empowering yourself.
There are, of course, risks associated with informing others. We cannot predict how others will respond; some may be totally understanding and supportive of your experiences, and there may be those who will have doubts and may even cast suspicion. You know the truth, and you know best whether you feel mentally prepared to endure the consequences of such a decision.
I feel that you are a courageous young woman. Be sure to surround yourself with supportive individuals who can help nurture your spirit as you begin the process of disclosing to others what you have endured over the past few years, and why.
Please feel free to contact me again in the future for additional support.
Cathy McDaniels-Wilson, PhD
Adjunct Professor
Department of Sociology
The Ohio State University


text:
Fun Thing #1: Drop In and Decorate
Drop in and Decorate is the simple but profound idea of my blogging friend Lydia to encourage people hold cookie decorating parties and then deliver the cookies to shelters, rest homes, hospitals, or other locations where people will appreciate a delivery of hand-decorated cookies. Someone attending a Drop in and Decorate event will decorate the 10,000th cookie this season, which translates to 10,000 people who've been cheered by a brightly decorated cookie (so far!) You can read more about Drop in and Decorate at Lydia's blog, or find out how to hold a party at the Drop in and Decorate site. (And don't wait too long, because if you hurry, Lydia has sponsors who can provide cookie-cutters or coupons for discounts on cookie-baking supplies.)
Fun Thing #2: Kiwi Berries
Speaking of cookies, the second fun thing that caught my eye came from the blog Tea and Cookies, where Tea (another blogging friend!) introduced her readers to Kiwi Berries. I'm going to make you visit her blog to find out about Kiwi Berries, but I promise you will be charmed! (Now I'm obsessed with trying to figure out how I can get some to try myself.)
Fun Thing #3: Raising Chickens!
I'm not going to start raising chickens since it's probably not even allowed where I live in the middle of Salt Lake City, but I'm loving the guides to chicken-keeping on Mostly Eating. Check out A Beginners Guide to Keeping Chickens: Part 1 and A Beginner's Guide to Keeping Chickens: Part 2 if you want to see just what's involved in raising your own chicks! (Great chicken photos too!)
Fun Thing #4: Another Reason to Live by the Ocean
I'm guessing that many of you have heard of getting vegetables delivered by a CSA (Community Supported Agriculture) but would you believe me if I said you can also sign up for weekly deliveries of fish from a Community Supported Fish Co-Op (CSF)? Tammy from Food on the Food can tell you more about Something Fishy. (As if you needed another reason to want to live by the ocean!)
Fun Thing #5: The Year of the Brussels Sprout?
Most of you probably know that I also write about food for a site called BlogHer, something that requires me to make an effort at keeping up with what other food bloggers are writing about. As I was keeping track of what side dishes people are cooking for Thanksgiving this year, I realized food bloggers everywhere are taking brussels sprouts for a trial run. Even if you previously haven't been a fan of the little green mini-cabbages, these are some drool-worthy brussels sprouts recipes that might make you reconsider. (Be sure to check the comments, and if you have a good brussels sprouts recipe, do share!)
So those are my five fun things from this week. We can all use more fun in our lives, so if you have something fun to share from the week, please share with a link in the comments. If you need just a little more Friday Fun, you can use the label for Five Fun Things on Friday to see fun things I've shared on other Fridays!


text:
what do you guys think about this?
'); var yuipath = 'clientscript/yui'; var yuicombopath = ''; var remoteyui = false; } else // Load Rest of YUI remotely (where possible) { var yuipath = 'http://yui.yahooapis.com/2.9.0/build'; var yuicombopath = 'http://yui.yahooapis.com/combo'; var remoteyui = true; if (!yuicombopath) { document.write('
what do you guys think about this?
Don't know how great of a fit it is with Bethea already there, but I've always liked Reed.
He's really old.
it would be Bethea and Reed, they would move Zbikowski
One of the keys for the Colts is to manage the huge amount of cap space they have this year. If they spend it all on 4 year contracts then they won't have any flexibility for the next 4 years. So I expect them to go with a variety of 2, 3, and 4 year contracts so that the cap space can be evened out in the future.
Reed is the kind of player that I would expect them to consider for a 2 year contract. He's too old to be given a 4 year deal to be a cornerstone of the D but he might have enough left to make a positive contribution for 2 years.
At his age? No thanks
That would be hapless in run coverage.
Even at his age he is still an impact player. Just like Dawkins was in Denver. A 2 year deal would be fantastic for any team quite frankly. The man knows how to make plays.
I'd be open for a 2 year deal I mean he's better than what we have now of course but this is a young team and while a vet would be nice I'd like a long term solution too.
Bring him in.
First time in a long time, I've been happy with the team that was constructed, and now they struggle. I blame the coach.
He's old, but he'd still probly be our best defensive player. I guess I'd be on board with it if the contract was short and reasonable.
There are two types of quarterbacks in the league: Those whom over time, the league figures out ... and those who figure out the league.
At the very worst he'll be a good coach for our young defensive backs. They will be watching and learning from the best.
On a 2 year contract I say hell yes. This guy is a beast and even though he is long in the tooth I think he would be the perfect mentor for our young DB's and S positions. It would suck for Tom Z because we would need to move him for possibly a draft pick or something similar in value.
Would definitely take that
Smothered Chicken!
After last year we should just cut Zibby. He was horrendous.
Sounds like Robert Mathis wants Ed Reed in the Colts defensive backfield.
https://twitter.com/RobertMathis98/s...84979535814656I can give 20 reasons why the Colts have potential for a serious SB push. Its a mental game and we simply need to reed between the lines lol
that would be like tony the tiger says...grrrrrrrrrrrrrrrrrrrrrrrrrreeeeeeeeeeeeeeaa aaaaaaat!!!!
but without a stout o-line, we are a middle of the pack team


text:
19 fun car road trip activities
Turn an ordinary drive into a world of fun adventures and possibilities. more
You've taken your child to the doctor with a nasty bout of diarrhoea – next minute you're being told that your pride and joy has a "notifiable disease" and details of the illness are being forwarded to a government department.
This may sound scary – or even Big Brother-like – but don't panic, this is a routine process, and important for so many reasons.
Notifiable diseases are any diseases that are required by law to be reported to government authorities. Armed with this information, health authorities can then monitor disease, and provide early warning of possible outbreaks, pandemics or epidemics, and ensure the right medications or vaccinations are stockpiled and appropriate procedures for treatment are in place.
There is a list of about 65 notifiable diseases in Australia, which is reviewed regularly, and may also vary from state to state. Some examples of notifiable diseases are HIV, hepatitis B and C, typhoid, cholera, Ross River and dengue fevers, malaria, sexually transmitted diseases such as chlamydia and syphilis, as well as conditions which may have been caused by food poisoning like salmonella and listeriosis.
Communicable diseases for which there are vaccinations – for example, chicken pox, measles, rubella, whopping cough and mumps – are also notifiable conditions so governments can be aware of the impact immunisation, or the lack of, is having on the population.
Surveillance of communicable disease is undertaken at a state and national level. This is so:
Not really. If it is a notifiable condition, doctors and laboratories are required by law to provide certain State and Federal government departments with key information about patients and their illness.
On a national level, the information is forwarded to the National Notifiable Diseases Surveillance System which is part of the Australian Government's Department of Health and Ageing and responsible for monitoring the occurrence of infectious diseases throughout the whole of Australia. Information that identifies patients is always removed before.
If you require more information on notifiable diseases, your GP is a good place to start.
This article was written by Fiona Baker for Kidspot, Australia's best family health resource.
Last revised: Tuesday, 25 October 2011
This article contains general information only and is not intended to replace advice from a qualified health professional.


text:
The Louisiana Community and Technical College Board of Supervisors terminated South Louisiana Community College's pharmacy technician, nurse assistant and six other programs at somecampuses on Wednesday.
Some of those programs, however, still will be available on other campuses.
The Louisiana Board of Regents, the state's higher education policy board, requires that a program be terminated when fewer than eight students complete a program over a three-year period.
South Louisiana Community College Chancellor Natalie Harder said the board's decision Wednesday was a way for the school to get ahead of the inevitable and gives administrators time to reassign faculty and staff.
All faculty affected by the move will stay on as full-time employees responsible for other programs at their campuses or will be moved to another campus, she said.
"Doing it this way is more efficient for us," Harder said.
South Louisiana Community College is a public, two-year institution with eight campuses spread across the eight-parish area of Acadia, Evangeline, Iberia, Lafayette, St. Landry, St. Martin, St. Mary and Vermilion.
The terminations follow a massive statewide purge in 2011 in which the Regents cut more than 100 degree programs for not graduating enough students.
Joe May, president of the Louisiana Community and Technical College System, said the state's community and technical colleges have been looking inward over the past several years, trying to identify and eliminate duplicative programs and programs that don't typically lead to good-paying jobs.
"It's a great opportunity for us to take a look at what happens to people when they leave the school and align our programs" accordingly, May said.
Programs eliminated include:
- Patient care technician at the C.B. Coreil Campus.
- Medication attendant certified at the Evangeline, Gulf Area and Lafayette campuses.
- Marine electrician at the Gulf Area Campus.
- Energy systems technician at the Gulf Area Campus.
- Nurse assistant at the Teche Area campus.
- Patient care technician at the Teche Area Campus.
- Pharmacy technician at the Teche Area Campus.
- Residential air conditioning at the Teche Area Campus.
In a letter to legislators, Harder said new nurse assistant, patient care and pharmacy technician programs will be offered on the Evangeline Campus.


text:
LONG BEACH - For student Anthony Castro, a beginning photography class at Long Beach City College was the gateway to education.
"I was a high school dropout and didn't know if I could handle going back to school," he said. "I decided to take one photography class to see how I liked it, and I turned out to be pretty good at it. I went on to take math and English classes and now I'm on the dean's list." | See photo gallery
Holding signs that read, "I vote keep the photography department" and "Save Photography Save the Arts," more than 200 students and faculty members, mostly from the college's photography program, flooded the LBCC Board of Trustees meeting on Tuesday in protest of a plan to eliminate or reduce more than a dozen programs.
College administrators are considering cutting up to 17 programs in the 2013-2014 year for a savings of $2 million. The cuts could include layoffs of about 10 full-time faculty.
The college currently has about 200 academic programs and 308 full-time faculty.
Programs on the chopping block include: Air conditioning, auto mechanics, auto body, aviation maintenance, carpentry, Computer Proficiency for Academic Success, Diagnostic Medical Imaging, diesel mechanics, film, human services (drug and alcohol counseling), interior design, medical assisting, photography, physical geography, radio/TV, recording arts, real estate, sheet metal and welding.
Lynn Shaw, president of LBCC's faculty union, said the proposed cuts are shocking.
"It's a devastating blow to full-time faculty and a devastating blow to the community," she said. "The community needs more than just a college that offers only math and English. The arts and trade programs are a vital part of our college."
LBCC spokesman Robert Garcia said the programs could be eliminated, reduced or consolidated depending on staff recommendations.
An academic council of administrators and faculty will meet in November to discuss the cuts and make recommendations, he said. The list will not be finalized for several months. Trustees could vote on layoffs as early as January, once the list becomes finalized.
The college of more than 26,000 students has seen an overall 7.4 percent reduction in state funding in recent years and is now facing one its toughest financial times in history. In April, trustees approved a plan to lay off 55 employees and reduce contracts for 96 positions for a savings of more than $5 million.
LBCC administrators are planning for even tougher cuts if voters fail to pass Gov. Jerry Brown's November tax initiative. If the tax initiative fails, the college would be forced to cut up to $8.4 million from its $96 million general fund.
For now, college administrators are focusing on mostly low-demand career technical programs for possible reductions.
Officials said cuts to low-demand programs will help the college focus resources on the core courses needed for transfer and graduation, such as English, math and science.
Faculty and students on Tuesday said they were disappointed to hear that the popular photography program was slated to be reduced or eliminated. Several speakers before the board urged the college to reconsider cuts to the arts and other programs that have played vital roles in students' lives.
Steve Johnson, a 69-year-old Long Beach resident, said he decided to enroll in LBCC's photography program 10 years ago after making a midlife career change. Johnson is now earning his master's degree in fine arts at Cal State Fullerton.
"The photography program helped me find a new course in life and I know it's helped so many other students," he said. "I hope they can find some way to save it."
firstname.lastname@example.com, 562-714-2181, twitter.com/kellypuentept


text:
Thread Mill, Straight, Int, SC, TiALN, 1/4-36
SCIENTIFIC CUTTING TOOLS| Zoro #: G1909871| Mfr #: TM170-36A
Zoro #: G1909871Mfr. Part #: TM170-36A
$159.00 /ea
This item ships free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G1909871 Mfr #: TM170-36A
|End Mill Material: Carbide
|Overall Length: 2-1/2"
|Item: Thread Mill
|Thread Size: 1/4
|Flutes: 3
|Application: All Types of Metals, Composites and Tough-to-Machine Materials
|Type: Straight, Internal
|Overall Length (In.): 2.5
|Length of Cut (In.): 0.540
|Finish: TiAlN
|Cutting Dia. (In.): 0.170
|Nomenclature: TM
|Shank Dia.: 0.250"
|Thread Type: Unified Thread
|Pitch: 36
|Size: 1/4
|Country of Origin (subject to change): United States
Product Description
Thread Mill, Straight, Internal, 1/4, Thread Size 1/4, Pitch 36, Cutting Dia. (In.) 0.170, End Mill Material Carbide, Flutes 3, Length of Cut (In.) 0.540, Overall Length 2.5 In., TiAlN, Neck Dia. (In.) -, Neck Length (In.) -, Shank Dia. 0.250 In., Min. Bore (In.) -, Thread Type Unified Thread, Nomenclature TM, For Use With -, Application All Types of Metals, Composites and Tough-to-Machine Materials
Restrictions and Compliance
- *2 : California Proposition 65 : This product contains a chemical known to the State of California to cause cancer.


text:
Police said the man was screaming in pain and had numerous bruises, cuts and open wounds. He was bleeding heavily from his mouth and chin, and several of his upper teeth were missing, according to the reports.
The man's hands and feet were bound with cords, he was blindfolded and his pants were down to his ankles, police said in the reports. Witnesses told police the man had been trying to walk down the street.
The injured man told police that three men armed with baseball bats and guns had beaten him inside the rear upstairs apartment at a home in the 900 block of Columbia. Inside the apartment, police found "blood all over the floor of the kitchen," along with an overturned chair and a bloody stick, the reports said.
A woman told police she had seen two men run from the house, get into a black SUV and flee eastbound on Columbia, the reports said.


text:
In Dire Need of Some More Rest
The low-volume market rally Friday didn't do much to change my feeling that major averages are ready to pause here and consolidate gains.
In other words, after two straight days of institutional selling Wednesday and Thursday, investors still have good reason to tread cautiously. It's likely long-term investors aren't paying much attention to the increasing signs of distribution in the indices -- but if you're a top-down investor and started buying high-quality names after the market confirmed a new uptrend Nov. 23, there's nothing wrong with taking partial or full profits here. If recent new buys are struggling, meanwhile, protecting capital and keeping losses small would be a sound strategy....446 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
Already a Subscriber? Please login.


text:
I immediately regret that title =)
Flashback to my pain-in-ze-butt public speaking class where they made us watch and critique Rachel Ray's TV presence on her show 30 Minute Meals. I, of course, sat in the back row of the lofty lecture hall but didn't let it stop my hand from jotting up the second my professor asked for an opinion. "If she says EVOO or YUM-O one more time I'm pretty sure I might die!" Surely she didn't disappoint, and said it a few dozen times while I watched in horror. Luckily I wasn't prepared to off myself so close to graduation. Well played RR, well played.
That being said, let's get on with the cliche blogger cinco de mayo post. Because, honestly, I freaking LOVE mexican food. I think just about every other recipe on here is a fiesta on a plate. But you won't find any mystery meat or questionable processed cheese products here! No way.
Because when it comes to Mexican food,
Sketch is out and VEGGIES are in! <3
Grab a fork, will ya?
Miami-Inspired Mexican Chop Chop
Guac-This-Way Guacamole Round-Up
What's for Dinner? Find out with our FREE weekly recipe newsletter!


text:
found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already neutered, purebred, a special needs pet, up to date with shots, good with dogs, and good with cats.
Ty, a Austin Pug dog was adopted! Here's how you can benefit by looking at adoption as an option to buying a Pug for sale in Austin, or seeking a Pug dog from a breeder in Austin.


text:
La ubicación es perfecta, cerca de todo en el centro, y hay ascensores. El desayuno era delicioso. El personal era muy amable. Un poco de frío, pero era invierno en Aspen. No tengo quejas
Fácil para llegar caminando a la ciudad, buen precio. La habitación era pequeña y vieja. El ventilador hacía un ruido raro cuando llegamos.
This place was big, beautiful, and in a perfect location. It was extremely clean, the staff was very nice and helpful. I will stay here again on my next trip. Beautiful rooms!
If you want space, the Gant is a great option. We opted for 3 BR condo. (Note: the 3rd bedrrom is small.) Would definitely stay there again.
This is my second time to stay at The Gant and I was just as pleased with the accommodations, staff and location as before. I enjoy being able to walk to anywhere you want to be in Aspen in 5-10 minutes or you can take the Gant's shuttle. The Saturday Market is awesome and you should put it on your list of things to do. The Gant is on the quieter end of Aspen and I really appreciate that. My only hiccup was the beds weren't comfortable - not any of the three in Unit D-106. Of course, I sleep on a firm Tempur-Pedic mattress at home so that's hard to live up to.
The condos are tucked away at the base of the mountain within a short walking distance to all of downtown Aspen. The staff was attentive and courteous and the condo shuttle vans provided a way to get to the ski resorts (and downtown if you didn't feel like walking) quickly and easily. Two large hot tubs and a heated pool were ideal for soaking after a day on the slopes. Our condo was a good size and very well appointed, clean, and modern. Overall the grounds and amenities were very well maintained. The only problem was that you could hear what we presumed to be the hot water pipes knocking in the ceiling regularly throughout the night. We were on the first floor and this could have been isolated to our unit but if I go back I will request a top floor unit.
Very nice complex. out of the way from noise. Excellent staff and shuttle will take you anywhere. Comfortable well decorated rooms. Little bit of noise from adjacent units. I would stay there again in an instant!
The Gant is located within walking distance west of the base of Aspen Mountain. Our upper floor unit had two bedrooms, dining room, living room w/fireplace, balcony, and full kitchen. In summer, it was a little warm as it is not air conditioned. Staff was very friendly. Nice Pool and Tennis courts. Would definitely stay again.
I will stay there any chance I get! Easy location, with great shuttle service and friendly, helpful staff that helps you with all of your needs! The views, hot tubs and pools are unbeatable. Thanks for another great stay.
The Gant is an awesome place to stay, especially with friends and family. We hope to get the chance to stay there again.
We loved our stay at The Gant! The resort staff was friendly and helpful, and upgraded us from a one bedroom to a two bedroom upon arrival. The condo was clean, had every imaginable amenity (including a Jacuzzi tub and steam shower), quiet, and spacious. The property was beautiful, and close to town! We loved the hot tub after a long day of hiking...can't wait to stay here again!
Good location easy to walk to town and shuttles whenever you need if you don't like walking.


text:
Water Bottle Program
Facilities management working in conjunction with the PCCS and MESS (Murray Environmental Students Society) has facilitated a campaign called "take back the tap" which urges both water conservation and the reduction of plastic water bottle usage on campus. Since the campaign inception in 2010 MSU has installed twenty six water bottle filling stations in the last two years that have diverted the equivalent of over 100,000 water bottles. The filling stations are in nearly every residential hall and classroom building across campus. Facilities management has also been working to replace all traditional watering systems to underground watering systems.


text:
"Hey Liz, I don't know my rating at all, but I think I'm good for someone with little tennis history. I picked it up more or less last year while I was still in Sacramento, CA. I'm a fun play since I'm competitive but not very…"
Liz has not received any gifts yet
© 2017 Created by Mark / The Mayor. Powered by


text:
Cool Hunting's Best of the Web Round-Up
by Miriam Brafman
1. Undercover SS10
Check out this series of mostly black-and-white stunning images from the Japanese high fashion brand's lookbook.
via Scoute
2. Rebranding Playboy
For a school project, MFA student Alex Cornell explains his process of creating a drastically new visual and editorial direction for Playboy Magazine that favors intellect over nudity.
via ISO50
3. Letters Lubell
Letters Lubell prints charming cards and paper goods on an antique press in Brooklyn. The outfit uses soy-based ink on recycled paper.
via We Love You So
4. Field Notes âJust Below Zeroâ
Field Notes recently introduced a limited edition series of their classic memo books in muted greys and blues.
via Design Work Life
5. Peter Saville Wrapping Paper
We love Creative Review's awesome roundup of the best seasonally-inspired design products.
6. Faabric.com
Created by web designer Jarred Bishop, Faabric.com makes for a beautiful and simple way to bookmark and discover clothes on the web.
7. Billy Jealousyâs Whipped Cream Shave Lather
Billy Jealousy's new lather for men uses a blend of lavender and bergamot that's also colorant and paraben-free.
via The Moment
8. The Portfolio of Mikey Burton
Philadelphia-based graphic designer Mikey Burton has an impressive portfolio that consists of letterpress work, gig posters, packaging and more.
via The Takeover


text: If you are one of the many Cape Town sport enthusiasts looking for great ways to save on leisure sport, you will love Groupon, where you can find coupons for leisure sport to enjoy in Cape Town and the surrounding area all the time. Ever dreamed of trying a new leisure sports activity such as sky diving or hang-gliding? Look out for a local Cape Town coupon for adventure sports and experience the ultimate adrenaline rush. Use a coupon for leisure sports to take a cycling tour of Cape Town and enjoy the great sites of the city, or discover new sports you can enjoy regularly. Groupon is perfect for those looking for great leisure offers for once-in-a-lifetime activities or day-to-day ways to stay in shape, and their great coupons allow you to enjoy leisure sports and other activities with discounts of 50 per cent or more.


text:
NEW YORK ( TheStreet) -- Greg Porter has this frightening diagnosis for e-health care investors: The digital diseases of piracy and commodification of information that have debilitated the music, publishing and financial services industries have infected their field as well. "The theft of protected, personal health information has never been higher," he told me in a brutally frank phone call on the sad health of digital patient data. Porter is no quack. He's the founder of Allegheny Digital, a small Pittsburgh information security company, and an adjunct faculty member at Carnegie Mellon University, where he pioneered the curriculum on information security in the health care industry.
"I'm trying to let anyone within earshot know about this," he said. The trouble is, few in the industry appear to be listening. A stunning 21 million health care records have been compromised since the fall of 2009; that's when the U.S. Department of Health and Human Services began keeping track. The agency goes as far as to post these breaches on an agency website "Wall of Shame." Last year, the Utah Department of Health alone inadvertently exposed some 780,000 patient records. "You almost become numb to it after a while," he said. "You wonder, 'Does it matter? Does the public care?'" A healthy health care market?
Investors need not bother with med school to learn that health care in the U.S. has belligerently resisted the digital age. Most experts I spoke say it's roughly a decade behind the leading edge of information age. But like it or not, health care is going digital. The sector is undergoing a shock-treatment regimen of federal mandates such as the Patient Protection and Affordable Care Act and stimulus enticements from the American Recovery and Reinvestment Act. And investors and blue chip companies are rushing to cash in.
Behemoths such as Dublin, Ohio-based Cardinal Health have been pushing electronic health care solutions with consulting services for small practices. New York-based start-up ZocDoc claims 2.5 million users -- and Jeff Bezos as an investor. Just last week, Boston-based QPID, an electronic medical records search tool to help doctors pre-screen patients, announced it had raised $4 million from Boston-based Partners Innovation Fund and Matrix Partners.
- Log In
- Newsletters
Access insights and guidance from our Wall Street pros. Find the product that's right for you.
- Action Alerts PLUS
- Daily Swing Trade
- Income Seeker
- Quant Ratings
- Real Money
- Real Money Pro
- Stocks Under $10
- Top Stocks
- Trifecta Stocks
- Real Money Pro Portfolio
- Chairman's Club
- Compare All


text:
MiniDrivers – Chapter 4×06 – 2012 Monaco Grand Prix
MiniDrivers are back! The most famous highlights for the Grand Prix are here again to show you the new vision of the races. What can we ask about the 6th race of the season where we had the 6th different winner? It's clear… To see the craziest stuff in Formula One with MiniDrivers. Just enjoy the Monaco GP with your favourite characters.
Video Rating: 4 / 5
Uploaded by SeventyBuckss.
Video Rating: 5 / 5


text:
Spend two hours in the UK. The year is 1984 and your friends are wear black.
"this film has been rescued from an old mildewed-and-damaged VHS cassette tape so the quality in the first few minutes is pretty poor, but it settles down fine just in time for the action inside the club itself. The original video was commissioned by the couple who ran the club (Annie and Pete Swallow) and was distributed amongst family, friends and people who frequented it. I can't remember if there was a charge for it at the time [thanks to the commenter who told us it was £2], probably was. This is the complete full length video as originally presented." – Patrick Torsney
For more info: wikipedia.org/wiki/Goth_subculture


text:
Don't have an account yet?Click here to create one now.
Euro and Yen prices are indicational only. Please note that website transactions will be made in GBP or USD only.
Your basket is empty!
For all designs of Mirrormen t-shirts, click here.
Click here to view the size chart.
Email: email@example.com
Tel: 020 7935 5550 / 012 7186 7057


text:
Effectiveness of Parent-Child Interaction and Emotion Development Therapy in Treating Preschool Children With Depression
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Behavioral: Parent Child Interaction Therapy-Emotion Development (PCIT-ED) Behavioral: Developmental Education Parenting Intervention (DEPI)
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Early Intervention in Depression: Dyadic Emotion Development Therapy for Preschool Children
- Depression diagnosis and severity using the Preschool-Age Psychiatric Assessment (PAPA) for major depressive disorder (MDD) module [ Time Frame: Measured at Week 14 ]
|Study Start Date:
|October 2007
|Study Completion Date:
|October 2010
|Primary Completion Date:
|August 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
Participants assigned to Parent-Child Interaction Therapy-Emotional Development
Behavioral: Parent Child Interaction Therapy-Emotion Development (PCIT-ED)
PCIT-ED includes fourteen 1-hour therapy sessions over 14 weeks. Sessions will focus on positive parent-child interactions skills, ways to manage emotions, and relaxation techniques.
Other Name: PCIT-ED
Active Comparator: 2
Participants assigned to Developmental Education Parenting Intervention
Behavioral: Developmental Education Parenting Intervention (DEPI)
DEPI includes 14 weekly, 1-hour education sessions covering a range of child development and parenting topics. Classes are in a small group format and will emphasize emotional and social development.
Other Name: DEPI
Detailed Description:
While growing up, children experience a range of emotions that change with development and environment. Although all young children experience sadness at times, a main characteristic of young children is their ability to experience joy and excitement in pleasurable childhood activities. When a child seems perpetually sad and no longer seems interested in previously enjoyed activities, the child may be showing signs of early onset depression. Children who are depressed are at increased risk for a wide range of social, psychological, physical, and achievement-related problems. Two previous studies have established the validity of early onset depressive syndrome in preschoolers, confirming the need for treatment during the preschool period. This study will specifically adapt parent child interaction therapy (PCIT), a proven effective treatment for preschool disruptive disorders, for use in preschoolers with depression and will include an additional component to focus on emotion development (ED). The study will evaluate the effectiveness of PCIT-ED in treating depression in preschool children.
Participation in this two-stage study will last 16 weeks and will consist of initial assessments, 14 weeks of therapy, and a final assessment. Stage I will be used to assess the acceptability and reliability of the PCIT-ED manual, which will guide the treatment sessions. The protocol and assessment schedule will be the same for Stage I participants and Stage II participants assigned to PCIT-ED.
The initial assessments will include both child and parent participants. Child participants will be asked to complete a series of tasks, which will include playing with games and toys, making selections based on feelings, completing stories started by a research assistant, and participating in other activities designed to be fun and exciting. Parents will be interviewed about their child's feelings, emotions, behaviors, and development and also about how their child gets along at home, in school, and with friends. Parents will also answer questions concerning their own mental health and drug history, parenting style, and moods.
Participants will then be randomly assigned to receive PCIT-ED or Developmental Education Parenting Intervention (DEPI). Participants in both groups will attend fourteen 1-hour therapy sessions over a period of 14 weeks. For those assigned to PCIT-ED, most sessions will include both parent and child participants, but some will include parents only. During the parent-only sessions, the goals and procedures of upcoming therapy visits will be explained to parents. During sessions with both parent and child, participants will be taught positive parent-child interaction skills, ways to manage emotions, and relaxation techniques. After each therapy session, participants will be given homework that will involve practicing the skills learned in therapy sessions at home. At three points during the study, parents will also be asked to complete a brief questionnaire about their thoughts and feelings toward the therapy process. The therapy sessions for the participants assigned to DEPI will provide basic education in all areas of preschool development, with emphasis on social and emotional development. The initial assessments will be repeated for all participants at the end of treatment.
|Ages Eligible for Study:
|3 Years to 6 Years (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Meets DSM-IV symptom criteria for MDD based on parent report on PAPA
- Currently resides and has resided with primary caregiver for more than 6 months prior to study entry
Exclusion Criteria:
- Neurologic disorder (e.g., seizure disorder, closed head injury)
- Autistic spectrum disorder
- Has an IQ of less than 70, based on past testing or clear marked developmental delay
- Currently participating in psychotherapy
- If taking a psychotropic medication, must remain on stable dose of that medication throughout the course of study participation
Please refer to this study by its ClinicalTrials.gov identifier: NCT00595283
|United States, Missouri
|Washington University School of Medicine Early Emotional Development Program
|St. Louis, Missouri, United States, 63108
|Principal Investigator:
|Joan L. Luby, MD
|Washington University School of Medicine
|Responsible Party:
|Joan Luby, MD, Principal Investigator, Washington University School of Medicine
|ClinicalTrials.gov Identifier:
|NCT00595283 History of Changes
|Other Study ID Numbers:
R34MH080163 ( U.S. NIH Grant/Contract )
|Study First Received:
|January 4, 2008
|Last Updated:
|March 20, 2013
Keywords provided by Joan Luby, MD, Washington University School of Medicine:
Preschool Onset Major Depressive Disorder
Preschool Depression
Emotion Development
Parent Child Interaction
Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
ClinicalTrials.gov processed this record on September 21, 2017


text:
Management Sponsored by
Change is necessary and inevitable in today's fast-paced market. In addition to new competition entering the market, existing beauty brands are constantly extending their overall product lines and positioning, launching new products to keep up with retailer and consumer demands.
Repositioning an existing brand brings about unique challenges that new and emerging brands do not face. While new brands suffer from the challenge of defining and creating their unique voice on a blank canvas, existing brands never get a second chance to make that first impression. Brands already in existence must acknowledge the established perception of the brand as they balance the next steps, trying to capture a new audience while holding on to their existing one.
In addition, an existing brand often faces the temptation to treat every problem equally. This mistake can result in the proverbial "throwing the baby out with the bathwater." How do brands decide what they should use versus what they should lose? The answer is having a process designed to properly define all the objectives before anything new is created.
Today's most innovative companies and brands are seeking creatives to lead this process so that the resulting creative work gets to the heart of the matter at every level. MSLK's approach is to begin with exercises to help unify the team's key stakeholders from the outset.
This process begins by unearthing all the brand's challenges and helping the internal team come to a collective agreement as to which issues are at the center, what issues are byproducts and what are unrelated challenges. There are a variety of exercises MSLK uses to unify team perspective, including visual brand audits, stakeholder interviews, and brainstorming sessions focusing on idea convergence and hierarchy. The culmination of these exercises is an assessment of common themes. MSLK likes to invite teams to its studio to experience these themes tacked up on office walls. This immersive experience brings a new level of clarity, allowing you to stand back and assess.
Another major part of this unifying process comes from listening to customers—their perception provides crucial insights that emerging brands often lack. If ever there was a time to listen to unfiltered customer feedback, it would be now.
MSLK believes qualitative market research early in the process can help unearth the attributes your customers associate about your brand in their own natural language. For example, there is no sense trying to position your brand as "trendy" when the perception is that brand is "tried and true."
Qualitative research can help beauty brands realign themselves with their core strengths and weaknesses. Moving forward, it will be the design and marketing team's challenge to play up the strengths and innovate in the areas of weakness. It may be possible to evolve and grow in both areas, but customers are usually most resistant to change in the areas they consider to be your strengths. Rarely would we suggest a radical repositioning around the areas that are currently working for a brand.
Once the team has come to an agreement and is aligned on the objectives, a succinct creative brief should be created to capture this data. Your design and marketing team work hand-in-hand to create this brief in order to ensure that the objectives and implied solutions are targeted and actionable. There's nothing worse than a creative brief too vague to ever be translated into compelling, visual, creative solutions.
If you would like to see multiple design directions explored, your brief should frame a rationale for each direction. MSLK refers to these as "targeted design directions." These targeted directions will allow you to explore the overall feeling of the brand by dialing up different attributes. These attributes might be characteristics such as "performance," "environmentally friendly," "hydrating" and so on. They may also describe degrees of evolution from the current brand positioning, from minor to radical. As a rule of thumb, each direction should tackle no more than three attributes.
This targeted approach does not limit the creativity of the team. Rather, creativity thrives within well-defined parameters, so that the innovations produced are most meaningful to your brand.
The final creative brief should then be reviewed and approved by all of the stakeholders before moving forward and starting with any design.
This is where dreams are fulfilled ... or nightmares begin. However, armed with your creative brief, the design development process should be a structured and efficient one, avoiding endless rounds and costly revisions later.
As the decision-makers review the designs, they should make sure the directions answer the stated objectives. In this manner, the inherently subjective nature of reviewing creative solutions can become an objective one.


text:
Taper Worries Clip Stocks Despite Positive Job Openings, Home Price Data
Stocks were firmly in the red in morning trading Tuesday, despite positive data on June job openings and home price data, as investors retreated following hawkish remarks by a Federal Reserve president.
At recent check, the Dow Jones Industrial Average was down 0.6%, while the S&P 500 and the Nasdaq were falling 0.5%.
Update: At 11 a.m. the Dow is now off 125 points, or 0.8%, while the S&P is losing 0.7% and the Nasdaq is down 0.9%.
Atlanta Fed chief Dennis Lockhart told Market News International the central bank could start curtailing its bond-buying program at any of three remaining Federal Open Market Committee meetings this year. In addition, Chicago Fed President Charles Evans, who typically leans more dovish, is also set to speak today.
June job openings rose to 3.936 million, the highest level since 2008. That reading is also up from May's 3.907 million openings and better than the 3.895 million economists expected.
On a year-over-year basis, June's job openings rose 3.8%, thanks to a 3.3% increase of private openings to 3.53 million, and government openings that rose to 402,000 from 372,000, the Department of Labor said.
Elsewhere, a survey by CoreLogic found that annual home-prices rose 1.9% in June, an 11.88% increase year-over year near a seven-year high. (My prices rose 11.93% year-over-year, the fastest pace since early 2006.)
Nearly every U.S. state logged home prices rises in June; Nevada led the pack, with 27% increase, while Delaware and Mississippi were the only states to see prices fall.
However, while some markets are hotter than others, overall the national average home price was still roughly 19% below the peak in 2006.


text:
Marcia Collection by Feiss
Chandeliers, sconces, and pendant lamps adorned with extravagance shake up your decor with lamps from the Marcia Collection by Feiss. Each lamp features a classic rustic iron finish for classic charm. The bejeweled furnishings on each lamp add another level of class and elegance. These fixtures are ideal for the hallway, foyer, and dining room.


text:
AKRON TOWNSHIP, Mich. - The Coast Guard has suspended its search for a man who disappeared after an airboat capsized on Saginaw Bay off Michigan's Thumb.
The Coast Guard received a rescue call around 8 p.m. Saturday evening after two men were stranded in the water off Fish Point in Saginaw Bay.
The Coast Guard was able to rescue one man clinging to the hull of the capsized boat.
He was lifted into the helicopter and transported to the Bay City Medical Center. He is currently listed in stable condition.
He told police that after the boat capsized the men decided they would swim to the nearest ice floe, but he returned to the capsized boat to await rescue and has not seen the second man since.
Rescue crews from Tuscola County Fire and Police Departments and a rescue airboat crew from Huron County also responded to the call.
Sunday morning around 8 a.m., the Coast Guard along with the Huron County Sheriff's rescue team began searching with underwater cameras for the second missing man.
The Coast Guard says a seven-hour search of the surrounding water and ice failed to locate the other man.
Copyright 2013 by ClickOnDetroit.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Squadron 74 — By Capt. Ken Kreisler
— January 2003
Quite Proper
|The flagship of Fairline's Squadron series offers an enticing blend of luxury and performance.
I like the way the English do things. Their speech, mannerisms, and courteous ways, especially with their nautical customs steeped in history as they are, are all done with just the right amount of—well, as their neighbors across the channel would put it, sang-froid, cool, self-assurance. "M'Lord, it"s the Spanish Armada. Shall we dispatch them?" "Straight away, Commander, at your leisure. That is, right after tea."
Another example is the little radio exchange I was part of as we were leaving our berthing space whilst sea trialing the Fairline Squadron 74, the British boatbuilder's new flagship that seemed to me to be a quite proper cruising vessel.
"QHM QHM, this is Fairline 74, over." (QHM stands for Queen's Harbor Master and must be hailed before any vessel can leave port.)
"Fairline 74, this is QHM, over," came the precisely pronounced answer.
"QHM, Fairline 74. Permission to leave Portsmouth Harbor for diagnostic testing in East Solent. Over." (The Solent is the body of water just outside of Portsmouth Harbor on England's southern coast.)
"Fairline 74, QHM. Permission granted. QHM standing by."
It was all well done.
Something else done well is the way Fairline builds boats. I make that assessment based on my firsthand experience a few years back with our company boat, a beautiful Phantom 43 that I spent several pleasant weeks on during her six-month stay with us. I found her to be a comfortable ride for my family and me as we visited many ports on our summer travel schedule. After a day aboard the 74, I could see that Fairline hasn't lost its touch.
Take, for example, our test boat's stunning woodwork, a combination of burr elm and eucalyptus that provided an eye-catching design element throughout, including the four staterooms below decks. (An optional three-stateroom layout includes a pair of walk-in closets in the master stateroom and a fully en suite head in the guest quarters.) Whether in the saloon, starboard dining space, port galley, or starboard helm station, the fit and finish and joiner work was superior; grains matched perfectly.
The layout on our test boat included a forepeak stateroom, a pair of twin berth quarters to either side, and an amidships master. Each has ample stowage areas including drawer, cabinet, closet, and cubby space to make packing for that long weekend or extended excursion easy. Design elements like the sculpted overhead in the master, the meticulously finished wood bulkheads in the hallway, and the wooden blinds in all the quarters add to the classy ambiance.
Noteworthy interior design continues on the main deck, where Fairline has created a space meant for entertaining and emphasizing ease of movement. The main deck is a comfortable yet elegant space not only pleasant to look at but easy to move about in. To starboard is the fully equipped helm, with its twin multidirectional, electrically adjustable Recaro leather chairs. While comfortable, I found they were too low for a good view of the water ahead, even on the highest setting. I had to sit up straight, which I imagine would be fatiguing after a while. To port is the optional breakfast nook complete with granite countertop and a pair of stylish stools. Other possible configurations here include a nav station and a dual companion seat.
The dining table, just aft of the lower helm station, can seat eight. The galley, opposite the dining area, has an electrically operated partition that can close off the cooking and prep space when necessary. Combine that with the shoji-like sliding door that can separate the lower helm station from the dining area, and a dinner aboard takes on a special, private quality.
This article originally appeared in the January 2003 issue of Power & Motoryacht magazine.


text:
{This is a repost from last year, but the timing seemed right for an encore ;) }
This is a favorite New Year's Writing Project that I've now done a few times with my classes.
This kit was created to be used by teachers in grades K-5. The materials are all differentiated for you and were designed to make modifications easy within your classroom. You can also use it year after year even if you change grade levels.
I recently completed this activity with my third graders in school as well as my first grade son at home. The differentiated pages and templates that are included made it a perfect activity for both.
I recently completed this activity with my third graders in school as well as my first grade son at home. The differentiated pages and templates that are included made it a perfect activity for both.
This is a great activity for the month of January as it focuses on resolutions or as I referred to them with my class...goals.
After editing with the teacher, the students wrote their final copies. I always try to culminate our writing projects with a simple art project. These pages include adorable colored clipart, but I opted to print them in black and white, photocopied them and let the kiddos color them in. We then mounted them onto construction paper and glittered the edges (because I'm fancy like that).
Included in this 15 page kit you will find the following New Year's-themed items:
-an intermediate brainstorming page to collect ideas
-a 3 detail web to organize writing
-a single detail web to organize simple paragraph writing
-primary-ruled draft paper
-intermediate-ruled draft paper
-primary-ruled final product paper
-intermediate-ruled final product paper
-a simple sentence activity page with space to illustrate for our -youngest learners
This year I hung them on my classroom door because I had some adorable owl writing to put up on my bulletin board in the hall. I displayed them as is, but the past few years I've done the board shown above using blowers and party hats. I've also taken photos of the students wearing party hats and using the blowers to display with their writing which is super cute too!
Happy New Year Friends!
Are you making any resolutions for 2013?keywords: classroom organization tips classroom organization ideas classroom organization supplies classroom storage classroom management classroom arrangement classroom organization skills organization ideas for the classroom organization ideas for teachers organization ideas for elementary classrooms decluttering a classroom declutter classroom kindergarten first grade second grade third grade fourth grade fifth grade sixth grade preschool 1st grade 2nd grade 3rd grade 4th grade 5th grade 6th grade easy bulletin board ideas projects New Year's back to school
Follow my Teacher Store so you don't miss
Flash Freebies or Discounted Debut Items and view my easy-to-navigate online catalog.
Check out CFC's Helpful Series for Teachers:


text:
phil wrote:Hi all
Retro posted a link to a sutta from Sutta Nipata in another thread, and it reminded me how many wonderful suttas there are in there. It seems a corner of the Canon that I am really unfamiliar with, so I would appreciate hearing some of your favourites so I could look them up.
My personal favourite is the Mangala Sutta, which is available in several translation at ATI. Here's one.
http://www.accesstoinsight.org/tipitaka ... .than.html
I think it really provides a complete plan for approach Dhamma, a great framework of reference for lay followers. There is a very good series of talks on it by Bhikkhu Bodhi here:
http://www.bodhimonastery.net/bm/about- ... ipata.html
Also, there is a wonderful recitation of it by Sayadaw U Silananda in Pali and English here:
Please scroll down to "Paritta Chanting, Burmese style" and click track 2.
The "mangalas" are translated as blessings, 38 of them, but the wonderful thing is that they are blessing that we earn or fail to earn through our own actions. Towards the end of the sutta there are very refined attainments, I usually don't get that far in my reflections on it - but early on there are many wonderful sources of reflection for lay followers working with undeveloped minds. A very helpful sutta for moral guidance, the most helpful I've found, personally.
Woven Cadences is a very old translation by E.M. Hare and quite outstanding from a literary point of view (possibly the most beautiful translation ever of a Buddhist text), but unfortunately it's too free a rendering to be relied on for learning Dhamma.
The only accurate translation is Group of Discourses by K.R. Norman.
retrofuturist wrote:Does anyone have any recommendations on particular translations of the Sutta Nipata?
retrofuturist wrote:What about H. Saddhatissa's translation ( http://www.amazon.com/Sutta-Nipata-New- ... 0700701818 )?
I've seen a Youtube video of Bhikkhu Bodhi reading from it, so I assume he considers it to be a reasonable version. Has anyone seen this one, or any other works from this translator?
Dhammanando wrote:It's a fairly free rendering, and not a very good one, imo. I remember at E-sangha expressing surprise upon hearing that Bhikkhu Bodhi had chosen to use this translation rather than Norman's. But it turned out that the focus of his talks was chiefly suttas of a moralistic or devotional sort, whose contents can survive even in a poorish translation. Also, I was told by one of the posters that Bodhi often gives up on Saddhatissa's translation and supplies his own during the talks.
mikenz66 wrote:
I think I said that... Certainly in the lectures here http://www.bodhimonastery.net/courses/Sn/Sn_course.html Bhikkhu Bodhi often provides his own rendering of the Suttas.
Those lectures are well worth listening to, in my opinion, especially the first 12:
The Paritta (Protective) Suttas (Ratana, Mahāmaṅgala, Mettā).
They make a nice contrast to his talks on the Majjhima Nikaya, which has a more "analytical" focus, precisely because they are more "devotional".
sherubtse wrote:I agree that they are more devotional than his talks from the MN. They are also more concerned with practical matters of ethics and conduct. IMO, they are wonderful talks!
mikenz66 wrote:sherubtse wrote:I agree that they are more devotional than his talks from the MN. They are also more concerned with practical matters of ethics and conduct. IMO, they are wonderful talks!
I agree. Perhaps my post wasn't clear. I had spent a lot of time reading "In the Buddh'a words" and the MN and listening to Bhikkhu Bodhi's talks before I listened to the Sn talks. Those first few Sn talks give a wonderful insight into what lay Buddhists in Asia are exposed to and therefore what might be particularly important (though often overlooked) for Western beginners...


text:
The ability to leverage data created throughout the product lifecycle is a strategic advantage for product development companies in any industry. Integrating this data together in a single source of truth in PLM, managed centrally and accessible to stakeholders throughout the organization when they need it, enhances both the speed and accuracy of their decisions – accelerating time to market and improving product quality.
Windchill offers these advanced integration capabilities to bring together PLM data with eCAD, mCAD, ERP, and software information from across the enterprise into a single, multidimensional source for the latest product development information:
|MCAD Integrations
|Capture, control and share product design data from AutoCAD, Autodesk, CATIA V5, NX, PTC Creo, Pro/ENGINEER, and SolidWorks, and manage it within a single environment across the organization and throughout its lifecycle.
|Cadence Integration
|Design in your familiar Cadence environment while leveraging the powerful process and content management capabilities of PTC Windchill.
|FORAN Gateway
|Share a single, synchronized graphical view of functional and build structures.
|Windchill Info*Engine
|Share product data — in real-time or asynchronously — with other enterprise applications to improve the speed, efficiency and quality of product development.
|Windchill Enterprise Integrations
|Extend information assets to a wide range of users and applications for context-specific usage, like ERP, allowing them to derive maximum benefit across the entire organization.
|Windchill PLM Connector
|Exchange Product Information Across Different PLM Systems
|Windchill Software Integrations
|Create a single system that simultaneously manages both hardware and software deliverables and supports heterogeneous software development environments.


text:
Zeus is a very sweet 3-year-old, neutered, microchipped and up-to-date with immunizations. He loves to cuddle, play with toys and gets along well with other dogs. He is crate-trained, but needs instruction on house training. Due to a neurological problem, Zeus drags his front paws so he will need a home where he can walk on grass or other soft surfaces. Adoptions are the third Sunday of the month (not in December) at Pet Food Express, at Oak Grove and Treat Boulevard in Concord.
Juneau is 18 months old, very friendly, loves attention and knows some basic obedience. He is full of energy and would be best with an active family, and as a running companion. He rides well in the car and will even jump right into a crate. Juneau is great with humans but not recommended with cats or small animals. He was recently neutered and is ready to go to his forever home, Email firstname.lastname@example.com, call MUSH at 800-399-8155 or visit www.ncama.org and click on "rescue."


text:
NEW ORLEANS — From the biggest to the smallest and the highest to the lowest, every school at all three levels that qualified for the state boys soccer playoffs — the pairings which were announced Wednesday by the LHSAA — has a tough haul ahead.
Jesuit coach Hubie Collins, whose squad earned the No. 2 seed in Division I, and St. Martin's Episcopal coach Matt Millet, whose team picked up the 14th seed in Division III and other New Orleans-area coaches expressed similar sentiments about their squads' draw Wednesday.
"We're just one of 32 teams that made it into the playoffs, and they're all quality teams," Collins said. "We're one of 32, and each game is a knockout game. Everybody knows what happens if you lose."
Meanwhile, in Metairie, Millet was preparing his boys for a fight from the outset of the playoffs, which start Friday with the bidistrict round.
"I'm fairly confident in our guys, but we know that in the first couple rounds we have a couple good teams," said Millet, whose Saints host No. 19 seed Haynes Academy in the first round. "Hopefully we can make it to the second round."
The only New Orleans-area school to pick up a top seed was Isidore Newman, which is pegged No. 1 in Division III and will host No. 32 Houma Christian on Friday. The top seed in Division I was garnered by Lafayette, while Alexandria tops the Division II bracket.
Newman coach Matt Jacques said while his squad might be one of the favorites to make it to the state championship game Feb. 22 at Tad Gormley Stadium, he's telling the Greenies not to look look past their first-round contest.
"We have to take it one game at a time," said Jacques, whose team is 15-2-3. "That's how we do things here. We don't look ahead. We try to accomplish the task at hand."
Jesuit, meanwhile, is the highest Division I seed from the Crescent City at second, but Brother Martin is right behind at No. 3. The two District 9 rivals are in the same half of the Division I draw, and if each squad wins out, they could square off in a in the semifinals Feb. 16, roughly a month after Jesuit ground out a grueling, 1-0 regular-season win over the Crusaders.
Jesuit begins the playoffs by hosting No. 31 seed Natchitoches Central, while Brother Martin begins with 30th-seeded Live Oak in the bidistrict round. Both contests are set for Saturday.
In Division II, No. 8 Ben Franklin was the highest seed locally. Franklin coach Jose Ferrand said he was hoping for a bit higher seed, but the Falcons will deal with the hand they've been dealt — a first-round bye, then a regional date with the winner of No. 9 Lakeshore-No. 24 West Ouachita.
"I think our kids are ready," Ferrand said. "Hopefully we can put together a run to the state championship. I think my boys are capable of it.
"They're working hard and playing well. We've had a couple lapses in recent games, but I have confidence in my coaches (to get the team ready for the playoffs)."
Every team in the playoffs is shooting for a spot in the state championship games, which are scheduled for Feb. 22 (Division III) and Feb. 23 (Divisions I and II) at Gormley Stadium in New Orleans.
As New Orleans' only No. 1 seed, Newman enters the postseason with a target on its back. While the rest of the Division III draw will be gunning for the Greenies, Jacques said it's all part of the playoff atmosphere.
"There's going to be pressure no matter what your seed," he said. "It's the playoffs. It's win or go home."


text:
For earcans I use Sony MDR-7506 and the Apple In-ear Headphones. If I had some tats and more Genre's in my iTunes labeled Rock I may want the soon to be released Marshall Headphones. They come out in November and the price is TBA. I have to wonder if they come with a coupon for discount hearing aids. Want or want not?
"The heavy sound of Marshall has been carried over the world for nearly 50 years. Breathless roadies and roaring trucks have worked hard to make Marshall heard all across the globe. Now, time has come for you to carry this magnificent burden of rock 'n' roll all by yourself." – marshallheadphones.com
For more info: marshallheadphones.com


text:
Home » Barcode Scanner » Zebra LS2208 » LS2208-SR20007R-NA
Shop With Confidence:
- POSGuys Lifetime Support
- 20 Day Returns
- 5 Year Manufacturer Warranty
- Free Shipping
Zebra LS2208-SR20007R-NA150.0000 In stock POSGuys.com Barcode Scanner > Zebra Barcode Scanners > Zebra LS2208 Price: $150.00 Add to Cart
What's in the Box: LS2208-SR20007R-NA LS2208 Scanner Kit, Black with Scanner, Stand and USB Cable, USB InterfaceMore Information: Zebra LS2208 This is one of the longest and best selling scanners on the market, and for good reason. The Zebra LS2208 provides the kind of fast laser scanning that makes it a mainstay for almost any retailer. Adding in an auto-sense stand turns the LS2208 into a great dual-purpose handheld and hands-free scanning solution. Part Number:This is a listing for individual item LS2208-SR20007R-NA LS2208 LS2208-SR20007R-NA Zebra Zebra
Part Specifications:
- Color: Black
- Interface: USB
- Accessories: Stand
SSS-LS2208-50 5 Year Zebra One Care Select 3-Day Exchange Comprehensive Coverage for LS2208 $24.00 Add to Cart
SSS-LS2208-20-R 2 Year Renewal Zebra One Care Select Advanced Exchange Comprehensive Coverage for LS2208 - Must Have Select Coverage Prior to Purchasing Renewal $51.00 Add to Cart
CBA-R01-S07PAR RS232 Serial 9-Pin Female Interface Cable (Requires Power Supply) $24.00 Add to Cart
20-61019-02R LS2208 Gooseneck Stand, Color: Black $35.00 Add to Cart
20-61019-01R LS2208 Gooseneck Stand, Color: White $35.00 Add to Cart
CBA-U01-S07ZAR USB Interface Cable $25.00 Add to Cart
PWRS-14000-253R Symbol Universal Power Supply (5VDC, 850MA, CA-MX-JP-TW) (No Additional Line Cord Needed) $25.00 Add to Cart
CBA-U12-C09ZAR Zebra Cable, 9' Coiled, USB $28.00 Add to Cart
CBA-U10-S15ZAR Zebra Cable, 15' Straight, USB $39.00 Add to Cart
CBA-U09-C15ZAR Zebra 15' Coiled Cable - USB $78.00 Add to Cart
CBA-U29-C15ZAR Zebra Cable, Black, Shielded 15 Feet Coiled, USB $85.00 Add to Cart
CBA-K02-C09PAR 9 ft. Keyboard Wedge Cable for DS9808 $24.00 Add to Cart
Cart is empty!
Featured Product
Featured Product
Sign up for
POSGuys Emails
POSGuys Emails
Sign up for exclusive POSGuys promos.
(2 Per Month)


text:
San Diego, home of sun and sand, Shamu and the zoo, and everybody listening to the radio for … country music?
Don't laugh.
For the third straight month and the eighth time in 10 months, KSON-FM (97.3 and 92.1), San Diego's "New Country" station, finished atop the Arbitron ratings for persons 12 and older. And the gap between No. 1 and No. 2 — KHTS-FM, Channel 933 — jumped from tiny in November (5.9 share to 5.8) to rather significant in December (7.2 to 5.4).
"I'd love to take all the credit for it, and I'm sure Kevin (Callahan, program director) would, too, but the format is just so strong," said Rick Jackson, general manager of Lincoln Financial Media, which owns KSON. "Nationwide it's doing well. There's a lot of diversification, from Taylor Swift to Eric Church to Jason Aldean … a lot of people selling a lot of records and driving strong radio play."
Jackson knows KSON's success doesn't mean country is the most popular format in San Diego. But it's probably more popular than outsiders would think (never underestimate the diversity of our county), and KSON is the only station playing it; the station's last competitor, Clear Channel-owned KUSS-FM, switched away from country in 2011.
And the ratings aren't the only indication that Jackson and Callahan are doing something right. In September the station won a Marconi Radio Award from the National Association of Broadcasters as "Large Market Station of the Year."
• In the San Diego ratings, KPBS-FM (89.5), KYXY-FM (96.5) and KIFM-FM (Smooth FM 98.1, another Lincoln station) rounded out the top five in December. KFMB-FM (100.7 Jack FM), KGB-FM (101.5) and KIOZ-FM (Rock 105.3) were close behind.
Golden weekend
NBC is going all-out for the Golden Globes on Sunday, and San Diegans get extra programming thanks to the local affiliate, KNSD Channel 7/39, being owned by the network.
Instead of programming starting at 4 p.m. as in most cities, NBC 7/39 will begin at 3 p.m. with "1st Look Live on the Red Carpet," hosted by Shaun Robinson of "Access Hollywood" with correspondents Ali Fedotowsky, Sara Gore and Lilliana Vazquez. It's an extra hour of red carpet interviews … and who doesn't love those, right? That precedes the national red carpet show at 4 hosted by Carson Daly, Natalie Morales and Jeannie Mai.
The ceremony, hosted by Tina Fey and Amy Poehler, begins at 5.
• For those looking for an alternative, E! Network will have Ryan Seacrest — he must need the work — and Giuliana Rancic hosting red carpet coverage starting at 3 p.m., with a "Countdown" show beginning at 2.
Now Hear This
Tonight at 6 p.m. marks the 30th anniversary of the launch of 91X, which makes many of us feel pretty old.
Chris Cantore, U-T San Diego director of lifestyle and entertainment and a 91X alum, will be writing more about this next week, but we'll mark the anniversary with a trivia question:
What was the first song played? Answer at the end of the column.
Now Watch This
"Girls," 9 p.m. Sunday, HBO
Don't hate HBO's "Girls" because its 20-something heroines are totally self-absorbed and sometimes partially nude. Clutch creator Lena Dunham and friends to your heart because they are messy and funny and totally unlike any women in the TV universe.
On the new season of this button-pushing comedy, there are new characters (look for Donald Glover of "Community"), relationship nightmares (Sorry about your ex, Marnie), and what should be the unforgettable sight of Hannah on a controlled substance.
You'll laugh, you'll blush and you might hurl the remote, but you will never be bored. For that, you've got to love "Girls."
Karla Peterson
Trivia answer
The first song played on 91X on Jan. 11, 1983, was "Sex (I'm A …)" by Berlin.


text:
The first step in the contribution process is to open a ticket. Please do so through JIRA and not through GitHub. This ticket can be created by anyone with or without a CA. It is OK to create a ticket and submit a patch at the same time, but please be aware, if the ticket is later rejected, the time spend developing the patch will be lost. Therefore it is recommended that coding on non-trivial patches should be postponed until after the vetting process. One possible advantage to submitting a patch before the ticket is vetted, is that it might be vetted and screened all at once by the screener, if they choose to do that, saving some time.
After a ticket has been created it must be vetted. The "vetters" are a group of people who have been assigned the task of providing high-level validation of tickets. For example, if someone submits a ticket that says "We should make all data structures mutable", the vetters will most likely reject the ticket on the spot. However, a reproducible bug report affecting existing code will most likely be vetted without much ceremony. Several steps can be taken by ticket authors that will help insure that their request makes it through the vetting process in a timely fashion.
1) If the ticket represents a bug, please give example code of the problem. Vetters are asked to verify all bugs. A un-reproducible bug will be rejected outright.
2) If the ticket represents a feature request, please provide some extra information about the request that explains why the feature is needed, and why it cannot exist as a separate library in Clojure contrib. Often this extra information is a link to a mailing list discussion, an IRC log, or perhaps it evolved out of a conversation with Rich Hickey. In general, the more context given for a ticket, the more likely the it is to make it through the vetting process.