text:
Cutaneous Lupus Erythematosus and Elidel
The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2007 by University of Leipzig.
Recruitment status was: Recruiting
Recruitment status was: Recruiting
University of Leipzig
Information provided by:
University of Leipzig
ClinicalTrials.gov Identifier:
First received: September 19, 2005
Last updated: April 5, 2007
Last verified: February 2007
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Show Detailed Description
This trial evaluates the therapeutic effect of Elidel (pimecrolimus) in comparison to the corresponding vehicle in patients with chronic discoid lupus erythematosus (dLE) or subacute cutaneous lupus erythematosus (scLE).
|Lupus Erythematosus, Cutaneous Lupus Erythematosus, Discoid
|Drug: Elidel (pimecrolimus)
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
|Official Title:
|Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE)
Resource links provided by NLM:
MedlinePlus related topics: Lupus
Drug Information available for: PimecrolimusU.S. FDA Resources
Further study details as provided by University of Leipzig:
Primary Outcome Measures:
- therapeutic effect
Secondary Outcome Measures:
- local tolerability
|Estimated Enrollment:
|Study Start Date:
|June 2003
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Subjects may be included only if they fulfil the following inclusion criteria on the pre-treatment days (between Day -14 and Day -2) and on Day 1 (before first application of study medication):
- Female and male patients aged 18-65 years (females of childbearing potential may be enrolled provided they are routinely using adequate contraception in the assessment of the investigator).
- Patients with histologically defined dLE or scLE.
- The test sites (lupus erythematosus plaques) must be on the face only, and have a total sign score of 4 or more (sum of erythema, induration and scaling scores) and must be the same within a given patient (ie not differing in the sum for erythema, induration or scaling). Each of the 2 test sites must be at least 3 cm apart.
- The patients must receive a baseline medication with chloroquine.
- Patients must have been informed about the study procedures and medication and must have given their written Informed Consent.
- Patients expected to be available for the duration of the study and able to comply with the study visits.
Exclusion Criteria:
Any of the following criteria will disqualify a patient from participating in this study:
- Systemic therapy for lupus erythematosus within one month prior to first application of study medication in this study (steroids, retinoids, herbal medicines, etc) except chloroquine.
- Patients with systemic lupus erythematosus or patients whose chronic discoid lupus erythematosus appears to be spontaneously flaring or improving based on the experience of the investigator.
- Patients who are receiving oral medication, known to precipitate lupus lesions (e.g. procainamide, diuretics, piroxicam, beta blockers, griseofulvin, lithium and other psychotropic drugs).
- Topical therapy [i.e. corticosteroids, etc.] within 2 weeks prior to first application of study medication.
Patients with clinically significant medical conditions which could interfere with the conduct of the study. This includes:
- Renal impairment (creatinine > 2.0 mg/dl)
- Hepatic impairment (liver function test values above notable abnormalities; g-GT, ALAT, ASAT: 2x the upper limit)
- Haematologic disorders (haemoglobin, platelet, erythrocyte and leukocyte counts above notable abnormalities)
- Neurologic disorders (significant impairment of sensory and motor function as judged by the investigator)
- Patients known to be previously immunocompromised (e.g. lymphoma, AIDS, myelodysplastic disorders) or treated recently with immunosuppressive drugs or treatment (e.g. radiation therapy or chemotherapy). HIV tests are not necessary.
- Patients with clinically relevant cardio-vascular diseases (New York Heart Association [NYHA] III or IV)
- Patients who suffer from systemic or generalized infections (bacterial, fungal, viral)
- Patients with malignancy or history of malignancy.
- Patients who suffer from acute or chronic bacterial, viral, or fungal skin diseases. However, patients with tinea pedum and/or onychomycosis can be included. Likewise, only patients with acute herpes lesions are excluded.
- Patients with a history of drug or alcohol abuse during the past 1 year.
- Patients with known hypersensitivity to any of the ingredients of the study medication or to tacrolimus (the investigator will be provided with a list of ingredients of the study medication).
- Patients who have received an investigational drug within 4 weeks prior to the first application of the study medication.
- Patients who are unwilling or unable to provide Informed Consent or to participate satisfactorily for the entire trial period.
- Any other condition which, in the opinion of the investigator, would render the patient ineligible for the study.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00222183
Please refer to this study by its ClinicalTrials.gov identifier: NCT00222183
|Contact: Michael Sticherling, Prof. Dr. med.
|Contact: Christina Rogalski, Dr. med.
|Department of Dermatology, University of Leipzig
|Leipzig, Saxony, Germany, 04103
|Sub-Investigator: Christina Rogalski, Dr. med.
|Principal Investigator: Michael Sticherling, Prof. Dr. med.
Sponsors and Collaborators
University of Leipzig
|Principal Investigator:
|Michael Sticherling, Prof. Dr. med.
|University of Leipzig, Department of Dermatology
More Information
Keywords provided by University of Leipzig:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
Bornhövd EC, Burgdorf WH, Wollenberg A. Immunomodulatory macrolactams for topical treatment of inflammatory skin diseases. Curr Opin Investig Drugs. 2002 May;3(5):708-12. Review.
Katsiari CG, Liossis SN, Dimopoulos AM, Charalambopoulo DV, Mavrikakis M, Sfikakis PP. CD40L overexpression on T cells and monocytes from patients with systemic lupus erythematosus is resistant to calcineurin inhibition. Lupus. 2002;11(6):370-8.
Wellington K, Jarvis B. Topical pimecrolimus: a review of its clinical potential in the management of atopic dermatitis. Drugs. 2002;62(5):817-40. Review.
|ClinicalTrials.gov Identifier:
|NCT00222183 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 19, 2005
|Last Updated:
|April 5, 2007
Keywords provided by University of Leipzig:
Lupus erythematodes
Chronic discoid lupus erythematosus (dLE)
subacute cutaneous lupus erythematosus (scLE)
Additional relevant MeSH terms:
Lupus Erythematosus, Systemic
Lupus Erythematosus, Cutaneous
Lupus Erythematosus, Discoid
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Skin Diseases
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Dermatologic Agents
Immunosuppressive Agents
Immunologic Factors
Calcineurin Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 25, 2017


text:
SEATTLE, WA--(Marketwire - December 03, 2012) -
Dr. Quay's presentation will focus on breast cancer prevention through the diagnosis and treatment of the abnormal cells that are the precursors of cancer, so-called reversible hyperplastic intraductal lesions. His presentation will include:
"Using Atossa Genetics' patented, FDA-cleared medical devices and our patented high-complexity laboratory developed tests to diagnose reversible, pre-cancerous breast changes and then treat them locally with intraductal therapy provides a platform that has the potential to realize our goal of preventing breast cancer," stated Dr. Steven Quay, MD, PhD, FCAP. "We look forward to identifying forward-looking pharma and biotech companies with novel treatment formulations to partner in this new paradigm for breast health, intraductal treatment of pre-cancerous lesions."
The Cancer Genome Summit is the only meeting that brings together thought leaders from pharmaceutical companies, academia and the clinic, to discuss harnessing the cancer genome to revolutionize drug development programs and patient treatment choices. The presentations will include the latest clinical data. Sharing these insights holds the key to understanding how genes cause cancer and how diagnostics and treatments can be improved. This year's meeting will show attendees how to identify new drug targets, combat resistance mechanisms, streamline clinical trials, and improve clinical management. More information about the meeting may be found at Cancer Genome Summit.
About Atossa Genetics, Inc.
Atossa Genetics, Inc. (NASDAQ: ATOS), The Breast Health Company™, is based in Seattle, WA, and is focused on preventing breast cancer through the commercialization of patented, FDA-cleared diagnostic medical devices and patented, laboratory developed tests (LDT) that can detect precursors to breast cancer up to eight years before mammography, and through research and development that will permit it to commercialize treatments for pre-cancerous lesions.
The National Reference Laboratory for Breast Health (NRLBH), a wholly owned subsidiary of Atossa Genetics, Inc., is a CLIA-certified high-complexity molecular diagnostic laboratory located in Seattle, WA, that provides the patented ForeCYTE Breast Health Test, a risk assessment test for women 18 to 73 years of age akin to the Pap Smear, and the ArgusCYTE Breast Health Test, a blood test for recurrence in breast cancer survivors that provides a "liquid biopsy" for circulating cancer cells and a tailored treatment plan for patients and their caregivers.
Forward-Looking Statements
Except for the historical information contained herein, the matters set forth in this press release, including statements regarding Atossa's plans, expectations, projections, potential opportunities, goals and objectives are forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to risks and uncertainties that may cause actual results to differ materially from the anticipated or estimated future results, including the risks and uncertainties associated with the efficacy of Atossa's products and services, the market demand for and acceptance of Atossa's products and services and other risks detailed from time to time in the Atossa's final prospectus, dated November 7, 2012, filed with the U.S. Securities and Exchange Commission. All forward-looking statements are qualified in their entirety by this cautionary statement, and Atossa undertakes no obligation to revise or update any forward-looking statement to reflect events or circumstances after the issuance of this press release.
Digg this Bookmark with del.icio.us Add to Newsvine
breast cancer prevention
atypical ductal hyperplasia
Cancer Genome Summit

subset: commoncrawl


text:
No one likes spam. While most people think of it as being unwanted email, spam in the form of unwanted and bogus comments on a website is equally annoying. But on your Drupal site, you want users to comment and interact with your content, but you want to ensure that those comments are legit.
There are some Drupal modules that can help you automatically moderate the spam without having to manually delete hundreds or even thousands of comments daily.
Two modules in particular are AntiSpam and Mollom. Both of these modules help with the prevention and automatic deletion of spam in your Drupal site, however, they go about doing so in different ways. AntiSpam uses multiple services such as Akismet.
Mollom is a module that's developed specifically for Mollom's service. In addition to blocking spammy looking content, Mollom may block a known spammer based on information in their system. Mollom is free and also offers several different paid services for business and larger enterprise customers.
Those are two modules that I have used to control spam, which services do you use to prevent spam in Drupal? Be sure to let me know in the comments.
Check out the previous post in his Drupal series whereBrant talks about essential modules for developers. In his next post, Brant discusses the different pieces that you need to backup so you can restore Drupal. Find out more abouthosting your Drupal site at Rackspace.


text:
No Hidden Fees - No Credit Card Surcharges - Low Shipping Rates
Images shown may not be an exact representation of the actual product.You may contact us if you have questions about the exact specifications of this item.
The vise was designed to accommodate the widest possible array of firearms for cleaning, maintenance, or gunsmithing, and is easily configurable to handle bolt-action rifles, break-open shotguns, AR-15's, and handguns.
A central aluminum channel lets the user move individual components to the ideal position for their firearm. Each individual component then adjusts to the perfect position for secure support. The rear base features two adjustable offset clamps for a tight grip on a wide range of buttstock configurations.
The Best Gun Vise is extremely stiff and is made from high-quality, solvent-resistant material that will stand up to years of hard use.
Great for cleaning and gunsmithing
Highly adjustable design for maximum versatility
Non-marring contact surfaces
Rigid, solvent-resistant polymer stands up to years of hard use
Innovative, offset clamping mechanism on rear base
Express orders for items available to ship the same business day must be placed by 1 PM MST. Express orders received
after 1PM ready for immediate shipment will not be shipped until the following business day.
Note: Delivery times are approximate and although generally accurate are not guaranteed. FFL transfer issues may affect
delivery times.
Express shipping is only available in the continental US to non-PO Box addresses. AP/FPO addresses may add to the
delivery time.
Impact Guns is the gun shop for all your shooting needs. We offer a wide selection of firearms, including: handguns, shotguns, rifles, ammunition, rifle scopes and optics, as well as collectible machine guns and other NFA/Class 3 guns. Impact also services the needs of law enforcement and military with our wide variety of tactical weapons and accessories. Shop online through our 256-bit Secure Sockets Layer encrypted online gun store 24 hours a day!


text:
Of the current cast, which is your favorite?
21 Comments - Linear Discussion: Classic Style
At first, I wanted to see the game because of max, but I started to like Tycho more. Strong Bad can be such a jerk sometimes, but he has his funny moments. Heavy is very amusing when he tells stories to the other characters.
Overall, my favorite character in the game is Tycho Brahe.
In Poker Night specifically or as a whole?
Anyway, I'll vote Strong Bad just because it was so good seeing him in something new.
Tycho and Strong Bad are pretty funny, but I prefer playing with Max. Perhaps because he's so friendly compared to the others you don't feel as bad for losing -.-
Tycho because:
max didn't get his fair share of words
strong bad is too much of a sore loser
and Heavy is just wierd.
I bought the game for Tycho and Strong Bad, but Tycho wins because I am pleasantly surprised and greatly enjoy his suddenly-voiced-ness.
Though, after playing for a while, Heavy is gradually getting a special place in my heart.
Max is cool, but we have other means of hearing more of him anyway. Tycho is great, because it's his first time (I hope not the last time) to actually speak and interact with other known characters.
Heavy is not bad, either. He mostly gets funny lines and he definitely has his own distinct humor. As for Strong Bad, I was never fond of him.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
Monday, December 15
**Bullitt Central at Waggener (Boys). The JV game will be at 4:30 p.m. with the varsity game at 6 p.m.
Tuesday, December 16
**North Bullitt at Spencer County (G&B). 6 p.m.
**Bullitt Central at Oldham County (Boys). 6 p.m.
Wednesday, December 17
**Fairdale at Bullitt East (Girls). 6 p.m.
Thursday, December 18
If you currently subscribe or have subscribed in the past to the The Pioneer News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning The Pioneer News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
NEW YORK ( TheStreet) -- Facebook ( FB) shares continued their torrid pace to 2013, gaining another 1.25% to trade at $30.97 just days before its secret press event. Facebook sent out invites to the press earlier this week, saying "Come and see what we're building." It's unknown at this point what Facebook will announce, but many are expecting big news from the social media giant. Facebook's stock has gotten off to a strong start in 2013, gaining 20.09%, as investors feel more confident and bullish about the company's short and long-term prospects for generating revenue.
Nokia ( NOK) shares were enjoying a strong day, gaining 18% to reach $4.43 on the back of strong Lumia sales. Nokia said it sold 4.4 million units of the Lumia, -- up from 2.9 million in the previous quarter. However, the Finnish company also noted that seasonality and increased competition will negatively affect its handset division, when compared to the final three months of last year.
Apple ( AAPL) shares were little changed, after having been up more than 2% earlier in the session. News came that CEO Tim Cook met with China Mobile ( CHL) Chairman Xi Guohua to discuss "matters of cooperation." Apple has noted on several occasions that China is an exceptionally important market for the company, and signing a deal with China Mobile would bolster its presence in the country. China Mobile is the largest cell-phone carrier in the world, with more than 700 million subscribers. There are also rumors suggesting that Apple may make a cheaper iPhone, trying to expand into the sub-$400 smartphone market to capture market share.
The Close: Facebook ends at $31.30, up 71 cents or 2.32%; Apple ends at $523.51, up $6.41 or 1.24% and Nokia lands on $4.45, up 70 cents or 18.67%. Interested in more on Apple? See TheStreet Ratings' report card for this stock. -- Written by Chris Ciaccia in New York >Contact by Email. Follow @Commodity_Bull
- Log In
- Newsletters
Access insights and guidance from our Wall Street pros. Find the product that's right for you.
- Action Alerts PLUS
- Daily Swing Trade
- Income Seeker
- Quant Ratings
- Real Money
- Real Money Pro
- Stocks Under $10
- Top Stocks
- Trifecta Stocks
- Real Money Pro Portfolio
- Chairman's Club
- Compare All


text:
Note: This item is more than nine years old. Please take the publication date into consideration for any date references.
Print – Plain Text – Permalink
News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
Feb. 11, 2008
Largemouth Bass Seminar Set for Texas Freshwater Fisheries Center
ATHENS, Texas — If growing and catching bigger largemouth bass in your private pond or lake are your goals, mark your calendar for March 28 and 29.
Texas AgriLife Extension, Department of Wildlife and Fisheries Sciences, in cooperation with Texas Parks and Wildlife Department and the Henderson County Wildlife Committee, will present a seminar at the Texas Freshwater Fisheries Center in Athens entitled "The Largemouth Bass: Better Fishing Through Private Water Management."
To pre-register for the conference, call (979) 845-2604.
"The program is designed primarily for landowners who manage their own impoundments for bass fishing," said conference organizer Billy Higginbotham, Ph.D., of Texas A&M University. "Program topics will include basic pond management such as water quality, controlling exotic vegetation, bass diseases and parasites, fertilization, feeding and stocking strategies. There will also be sessions on cutting-edge bass management techniques. This program is a must for anyone wanting to raise and catch really big bass in their ponds."
Presenters at the conference will include some of the best-known bass experts from the southern United States. Barry Smith of the American Sport Fish Hatchery in Alabama will report on his efforts to use selective breeding to grow bigger bass that are easier to catch. Bassmaster Elite angler Alton Jones will speak on how to catch bass. There will also be a session on how to age bass using otoliths, a necessary component of successful management of a fishery. Attendees will also get a close-up view of modern scientific bass management as practiced by Texas Parks and Wildlife Department, including a behind-the-scenes tour of TFFC's ShareLunker spawning and rearing facility.
Program Highlights
Friday, March 28
Vendor set-up 8:00 a.m. to 10:00 a.m.
Registration 10 a.m. to 5: 30 p.m.
Program begins 1:00 p.m.
- Welcome — Phil Durocher, Director, Inland Fisheries Division, TPWD
- Pond Renovation — Jim Rogers, National Resources Conservation Service
- Aging Largemouth Bass Using Otoliths
- Measuring Ponds/Testing Water Quality
- Electrofishing/Shoreline Seining Demonstration
- Bass Spawning Facility Behind-the-Scenes Tour
- Catfish Fry
- Visit with Alton Jones
Saturday, March 29
- Basic Pond Ecology — Michael Masser, Texas AgriLife Extension Service
- Water Quality Management — Peter Woods, Texas AgriLife Extension Service
- Pond Fertilization/Fish Feeding — Peter Woods, Texas AgriLife Extension Service
- Fish Stocking Strategies — Malcolm Johnson, Johnson Lake Management
- Do-it-Yourself Fish Population Assessment — Billy Higginbotham, Texas AgriLife Extension Service
- Pond Management Mythbusting — Rich Noble, North Carolina State University
- Enhancing/Establishing Aquatic Vegetation — Rick Ott, TPWD
- Operation World Record — Allen Forshage, TPWD
- Largemouth Bass DNA Research Update — Dijar Lutz-Carrillo, TPWD
- Better Bass Fishing Through Genetics — Barry Smith, American Sport Fish Hatchery
- Aquatic Weed Control — Michael Masser, Texas AgriLife Extension Service
- Managing Problem Wildlife — Mike Bodenchuk, Wildlife Services
- Largemouth Bass Diseases and Parasite, Michael Masser, Texas AgriLife Extension Service
- "Ask the Experts" Panel
On the Net:
Publication — Permission is granted to publish, in whole or in part, any news releases on this page.
Print — A print-friendly version of the news release shows only the release with font sizes set to the browser default.
Plain Text — Plain text versions of TPWD news releases are provided for copying and pasting into editing software.
To copy text into an editing software:
- Click a Plain Text link to display the plain text page in your browser.
- Select all.
- Copy.
- Paste in a document in your editing program.
Permalink — This is a direct link to the news release, omitting the navigation context from the URI.
English/Spanish — News releases posted in both English and Spanish have one of these links.
If you have any suggestions for improving these pages, send an e-mail to email@example.com and mention Plain Text Pages.
(5.4.16 i)


text:
Lisa Jackson is leaving her post as administrator of the Environmental Protection Agency after four years heading the agency.
The New York Times led off its announcement of her resignation by suggesting she leaves after not being able to achieve "sweeping action to address climate change and other environmental ills" because of challenges from industry, Republicans in Congress and not enough support from the Obama White House.
The Obama administration is seen as having backed off broad-scale climate change actions spearheaded by the EPA as the ag industry and industry in general have counter attacked with their concerns about regulatory overreach.
Jackson was challenged repeatedly by Congress and often by the Republican majority in the House. In the Times article by John Broder, he wrote, "She was frequently subjected to harsh questioning that at times bordered on the disrespectful."
It is thought that Jackson is most pleased with one outcome from her four years—beating court challenges from industry that allows the EPA to classify carbon dioxide and five other gases as contributing to global warming and being defined as pollutants under the Clean Air Act. This was why the EPA was able to negotiate new emissions standards for cars and light trucks and is targeting power plants to require reducing greenhouse gas emissions.
There have been a number of proposed actions by the EPA that have concerned and/or angered segments of agriculture during Jackson's reign, and the ag industry is wondering what the environmental and regulatory agenda will be during President Obama's second term.


text:
Hot, dry summer weather brings about heat and drought stress on summer annuals. Stressed plants such as forage sorghums can occasionally accumulate dangerous concentrations of nitrates. These high-nitrate plants, either standing in the field or fed as hay, can cause abortion in pregnant cattle or death if consumed in great enough quantities.
Nitrates do not dissipate from sun-cured hay (in contrast to prussic acid), so once the hay is cut the nitrate levels remain constant. Therefore, test hay fields before you cut them, advises Glenn Selk, Oklahoma State University emeritus extension animal scientist.
Testing the forage before cutting gives you an additional option of waiting and allowing for the nitrate to lower in concentration before harvesting the hay. Some major sources of nitrate toxicity include annual sorghum-type plants, including sudan hybrids, sorgo-sudans, sorghum-sudans, millets and Johnsongrass.
A nitrate concentration of 10,000 parts per million (ppm) is considered potentially lethal to cattle.
The risk of nitrate poisoning cannot be totally eliminated, Selk says. However, here are some management techniques to reduce the risk of nitrate toxicity:
1) Test the crop before you harvest it. If it has an elevated concentration of nitrates, you still have the option of waiting for normal plant metabolism to bring the concentration back to a safe level. You cannot estimate nitrate content just by looking at the field.
2) Raise the cutter bar when harvesting the hay. Nitrates are in greatest concentration in the lower stem. Raising the cutter bar may reduce the tonnage, but cutting more tons of a toxic material has no particular value.
3) Know the extent of nitrate accumulation in the hay and the levels that are dangerous to different classes of cattle; i.e., pregnant cows, youngstock. If you still have doubts about the quality of the hay, send a forage sample to a reputable laboratory for analysis to get an estimate of the nitrate concentration and the extent of dilution that may be necessary to more safely feed the hay.
For more information, read OSU Fact Sheet PSS-2903.
Source: Glenn Selk, Oklahoma State University Emeritus Extension Animal Scientist


text:
Although we're known throughout the Dallas and Richardson region for our selection of new Honda models, we also carry a massive inventory used cars, trucks, SUVs and minivans. Whether you're searching for a competitive price on a used Honda Accord, Pilot, Civic, CR-V, CR-Z or Ridgeline, Lute Riley Honda is your destination. Along with a diverse selection of used Honda cars, trucks, and SUVs for sale, we also have a variety of used cars from other manufacturers, both domestic and import. Our sales team is standing by, ready to get you behind the wheel of used car, truck or SUV that you want and our financing team will make sure it fits your budget. With a variety of used car loan options to choose from, we're confident we can get you into a vehicle that your head and heart can agree on. Lute Riley Honda is the place to shop in the greater Dallas, Irving, Frisco and Richardson area if you want a competitive price on a quality used automobile. Come visit us in person at 1331 North Central Expressway, Richardson, TX 75080.
Here at Lute Riley Honda we work on developing long term relationships with our customers, and our outstanding customer service does not end at the sale. To help keep your newly acquired vehicle on the road for years down the road, make sure to schedule all maintenance, repair, and service at the Lute Riley Honda service center. Our service center is staffed with OEM Certified auto repair technicians, and we only use original Honda auto parts and accessories. Learn more about our state-of-the-art repair facility by contacting Lute Riley Honda today.
All advertised prices for new vehicles include destination charge but exclude state and local taxes, tags, registration and title fees, processing fee and optional dealer added equipment.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
SHEPHERDSVILLE - It's hard to do research when the computers available could be considered historic themselves.
If you currently subscribe or have subscribed in the past to the The Pioneer News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning The Pioneer News and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
Owner Of Desperado's Arrested In Federal Raid
CARENCRO, La. (KPEL) — 54-year-old James "Jim" Panos, the owner/operator of Desperado's Gentleman's Cabaret on the Evangeline Thruway in Carencro was arrested Wednesday during a federal raid of the business.
U.S. Attorney Stephanie Finley says Panos of Broussard was arrested on a federal complaint, charging him with maintaining a drug-involved premises. He's being held in the St. Martin Parish. Finley says "the investigation is ongoing."
Some of the other people arrested in the sting included 46-year-old Jennifer Panos of Broussard on a drug charge, 30-year-old Crystal Sampy of Lafayette and 27-year-old Tanja Lynn Clavier of Lafayette on numerous drug charges, 28-year-old Heather Marie Kelley of Breaux Bridge on numerous drug charges and prostitution, 39-year-old Louris Geri Lenoir of Carencro for committing prohibited acts and drug possession, 30-year-old Brian Sampy of Lafayette on active arrest warrants and 51-year-old Michael Jude Broussard of Scott on a bench warrant.
Federal authorities, as well as the Lafayette Parish Sheriff's Office, were at Desperado's throughout the day Wednesday, closing the frontage road during the investigation. The strip club has since been closed.
KPEL was the first news outlet to report that James "Jim" Panos was arrested.


text:
New Chapel
William Carey University has grown impressively over the past five years with record enrollments, new programs, and new facilities. However, a vital piece is missing from our campus — a chapel. Carey is currently the only institution of higher learning in Mississippi, whether public or private, two-year or four-year, without a chapel building on campus. We will rectify this omission with the construction of a small chapel on campus. Positioned adjacent to Chain Garden, the chapel's presence will testify to the Christian mission of William Carey University and will provide an intimate place for prayer, devotion, and worship, as well as for recitals and small weddings. The sanctuary will hold approximately 100, so weekly chapel services will continue to be held in Smith Auditorium.
While over half of the needed $600,000 has been raised, your support is necessary to complete the chapel. Help make the chapel a reality by sending a contribution with the attached pledge card or by visiting www.wmcarey.edu/GivingtoCarey and designating your gift to the chapel.
Your gift may be given in honor or memory of a loved one, mentor, pastor, or faculty member. Gifts of all sizes make a difference, and naming opportunities are available. Pledges can be fulfilled over a three-year period. For more information, contact Dr. Scott Hummel at 601-318-6497 or email@example.com. Give anytime by visiting www.wmcarey.edu/GivingtoCarey. All contributions to the chapel fund are tax-deductible.
Naming Opportunities
- Building $500,000
- Sanctuary $100,000
- Bridal Room $30,000
- Bell Tower $25,000 Named
- Vestibule $25,000
- Memorial Prayer Garden $20,000 Named
- Lobby Window $20,000
- Rear Window $20,000
- Piano $20,000 Named
- Communion Table $5,000 Named
- Stained Glass Windows $5,000 Named
- Circular Front Windows $5,000 Named
- Chandelier $3,500 Named
- Pews $3,000 1 of 20 Named
- Wall Cross $2,000 Named
- Pulpit $1,500 Named
- Vestibule Furniture $1,000 Named
- Pulpit Chair $750 2 of 4 Named
- Pulpit Bible $500 Named
- Choir Chairs $250 1 of 12 Named
- Memorial Bricks $100
- Pew Hymnal $50
- Pew Bible $25
Chapel Steering Committee
- George Berger
- Charles J. Brown
- Joseph Byrd
- John Clearman
- Chad Davis
- Robert and Linda Donnell
- Rossie Francis
- Ron Herrod
- Phillip Londeree
- Step Martin
- Tony Pascale
- Elton Raby
- Gary Shows
- Ralph Simmons
- David Spencer
- Don and Mona Stewart
- Randy Turner
- Juruthin Woullard
- Linda York


text:
THE SPRUCED UP theater to be dedicated for director James Dunn at College of Marin on Friday merely scratches the surface of the changes visitors will see. The theater is part of a new $36.4 million arts complex on the Kentfield campus that includes new classrooms and studios, a lobby for events, a gallery and other additions.
The complex houses about 84,000 square feet of visual and performing arts in two buildings connected by a courtyard. The visual and performing arts previously shared a single building of similar size, but much of the space was either rebuilt or renovated over the past few years as part of the college's $249.5 million bond program.
"These facilities put both the visual and performing arts into a very visual, front-and-center position," said Laura McCarty, the college's director of modernization.
The performing arts building, which occupies what is left of the original structure, saw the addition of new dance studios, classrooms, offices, meeting space, a theater lobby and ticket booth. The newly renamed James Dunn Theatre did not grow from its original 591 seats, but it has been upgraded with new lighting, mechanical equipment and other improvements.
Attached to the lobby of the performance building is a new fine arts gallery that will show the work of students, faculty and well-known artists from Marin and beyond. A show of surrealistic charcoal portraits by instructor Bill Abright will open Friday to coincide with the theater dedication.
Across the courtyard, a new 22,500-square-foot fine arts building houses a range of visual arts including painting, drawing, ceramics and metalwork. The building features a sleek design and state-of-the-art equipment, but it has not been without its problems, said Chester Arnold, a painting instructor and chairman of the art department.
"I think it will be a beautiful space," he said. "It has wonderful light and the ventilation system is relatively advanced, but there are still kind of quirks being worked out."
Chief among the problems is water that is blown into classrooms during windy storms, which college officials attribute to design errors by the architect. The college has budgeted $1.1 million to fix the problem with new glass panels and walkway coverings.
Other problems include noisy ventilation equipment in the sculpture and ceramics area, and a lack of fresh air in the painting area, Arnold said.
"We've got a great president who seems to be behind the art department and the whole program," he said. "We're in a really good position to get these things resolved."
Contact Will Jason via email at email@example.com or via Twitter at http://twitter.com/willjason


text:
By Soham Sarkhel and Jatin Thakkar
After the 2-0 defeat in the Test series where the West Indians had shown promising signs of a fight, they were expected to perform better with the inclusion of their IPL stars - Chris Gayle, Sunil Narine, Dwayne Bravo and Kieron Pollard in their line-up. However, what followed was a rather spineless performance from the West Indians which resulted in yet another 2-0 series loss (a 'whitewash', since the 3rd ODI got abandoned) against an efficient English team. Very much like the Test series, it was their bowling which comprehensively let them down – but this time, even their batting did not do them sufficiently proud.
Here is the series through the Impact Index prism.
Ian Bell, who made his comeback to the ODI side as the replacement for Kevin Pietersen was the highest impact player in the series (Series IMPACT 4.00) and was also rightly declared the Player of the Series. Bell was also the highest impact batsman in the series, something that even his conventional statistics confirm. His performance in the 1st ODI where he scored 126 off 117 balls (Batting IMPACT 8.11) was also the highest impact batting performance in the series.
Tim Bresnan was the highest impact bowler in the series. His performance in the 1st ODI (4-34 off 7.4 overs, Bowling IMPACT 5.00) was the highest impact bowling performance in the series. In fact, from West Indies, only Darren Sammy makes it to the list of top 5 bowlers. Except for him and Marlon Samuels, all the other West Indian bowlers failed to register a Bowling IMPACT of even 1 in the series. Given that both are actually all-rounders, this reveals that the West Indians lost the series on the bowling front rather than the batting.
Interestingly, amongst the four highest impact players in this series, two of them are from West Indies – namely Chris Gayle and Dwayne Bravo. Gayle, who missed the first ODI due to an injury, made his comeback to the West Indian side after almost 16 months with a typical whirlwind innings. Chris Gayle (53 off 51; Batting IMPACT 3.13), Dwayne Bravo (77 off 82; 5.09) and Kieron Pollard (41 off 52; 2.76) combined well in the 2nd ODI but West Indies' total of 238 was not enough to give England much of a fight.
Overall, four players absorbed pressure in this series – Dwayne Bravo and Kieron Pollard in the 2nd ODI and Ian Bell and Jonathan Trott in the 1st ODI. The 100 runs partnership between Dwayne Bravo (77 off 82 balls, Pressure IMPACT 0.69) and Kieron Pollard (41 off 52 balls, Pressure IMPACT 0.69) in the 2nd ODI (they came in at 79-4 and helped West Indies reach a competitive total of 238-9) providing one of the very few bright spots in the series for West Indies.
Darren Sammy, Tim Bresnan, Sunil Narine and Graeme Swann broke partnerships (Partnership Building IMPACT) whereas Tim Bresnan, Stuart Broad and Graeme Swann built pressure on the batsmen with quick wickets (Pressure Building IMPACT).
Only three players had an all-round impact in this series (both Batting and Bowling IMPACT above 1), namely- Stuart Broad, Tim Bresnan and Marlon Samuels (though, he just about makes the cut).
While 6 players registered a Series IMPACT of less than 1 for West Indies, only Eoin Morgan registered a Series IMPACT of less than 1 for England. Also, 7 English players were amongst the 10 highest impact players in this series. It is again this inconsistency as a team which cost West Indies in the end.
England registered a Team IMPACT of 2.26 in the series as compared to West Indies' 1.27, England's IMPACT being 78% higher than that of West Indies. The difference mainly came from the Team Bowling IMPACT in the series – England's was 2.10 as compared to West Indies' 0.76.
For more information, please go to www.impactindexcricket.com


text:
Branch Table with Bluetooth® Speaker
This item is currently not available.
Additional Information
Side Table has a Bluetooth® Speaker
- Convenient table has built-in speaker
- Play music, listen to a phone call or play a movie soundtrack
- Use indoors or in a protected place outdoors
This lovely, nature-inspired side table has a secret: It's a Bluetooth® speaker, too! Place the table in your living room, sunroom or on a protected porch and it's a convenient spot for your cup of tea or a potted plant. Then add to the ambience by playing music using any Bluetooth-enabled device, such as a cell phone, tablet or personal computer. Use the phone or other device to adjust the volume, pause the music or skip a track. You can also use it as a speakerphone, play the radio, or play the soundtrack to a movie you're watching. The table is made from cast aluminum that's been hand-finished to resemble aged brass, with a clear glass top. 5' power cord plugs into wall outlet.
Product Details
- Cast aluminum, glass
- 22" in diameter x 26" H
- Base is 15" in diameter
- Weighs 21 lbs.
- Bluetooth® Version: V2.1+EDR; Frequency: 2400.0 - 2483.5 MHz; Output: 12 VDC 1000 mA;
- Speaker: 10W max
- Adaptor: Input: 120 V AC 60 Hz; Output: 12V DC 1000mA
- Adapter plugs into connection at base
- Note: Small antenna projects from base; do not remove
- Operating range is 30 feet
- Sorry, no shipments to AA,AE,AF,AK,AP,GU,HI,PR,VI


text:
Valencia targets lefties, ready to compete in East
BOSTON -- Earlier this week, Danny Valencia was competing for a pennant in the American League Central, but now he's very much in the mix of the AL East.
Valencia officially joined the Blue Jays on Tuesday afternoon after being traded from the Royals the night before. Toronto acquired the corner infielder in exchange for catcher Erik Kratz and right-hander Liam Hendriks to provide additional depth off the bench.
The news caught Valencia a little bit off guard, considering the Royals are in second place, but he remains excited about the change of scenery.
"It's a great opportunity here," Valencia said. "Obviously this is a tough division, teams that are always really, really tough. I was fortunate enough to play in this division last year with Baltimore and see it on the other side. It's definitely going to be a fun time, and I think this team is going to be great. I'm looking forward to helping the Toronto Blue Jays win."
Valencia was acquired primarily because of his ability to hit left-handed pitching. That's an area the Blue Jays have struggled in a lot this season, and the issue became even more severe when Brett Lawrie and Edwin Encarnacion were placed on the disabled list.
The plan appears to be for Valencia to become part of a platoon at third base, with Munenori Kawasaki and Juan Francisco. Valencia also could see occasional playing time at designated hitter or first base but isn't expected to start at second, even though he appeared in a handful of games at that position in Kansas City.
Once Lawrie returns from the disabled list, Valencia's role becomes less clear. He'll likely remain on the roster and could still start at third vs. lefties while Lawrie slides over to second base. Blue Jays manager John Gibbons said it's too early to make those types of decisions and that Valencia will face a lot of lefties.
"I was never able to really pinpoint the reasoning why I hit left-handers better," said Valencia, who has a career .333 average and .879 OPS against lefties but is .227/.620 vs righties.
"Traditionally your splits should be better against left-handed pitching, but I can't really pinpoint anything. Obviously I feel comfortable in there, but it's one of those things that I carved something out for myself. You want to be able to hit lefties and righties, and I feel I can do that pretty well."
Gregor Chisholm is a reporter for MLB.com. Read his blog, North of the Border, and follow him on Twitter @gregorMLB. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Go back
Please wait..Game loads in 10 seconds.
Played today:0 | All times played:10116
Missing Plugins ?
Download Latest Flash Player,
Shockwave Player and Java Plugins here
Copyright © 2010 | DisneyTVGames.com. All Rights Reserved.
This site is not affiliated with the Walt Disney Company.
All games, animations, Characters, images, and sprites are copyright to their respective owners or creators.


text:
Andrew Flintoff believes Kevin Pietersen has been made a scapegoat for England's Ashes failure and questioned the team spirit in the camp after watching the treatment of his former colleague.
The England & Wales Cricket Board have effectively ended Pietersen's international career this week, with the oft-controversial but undeniably gifted batsman joining team director Andy Flower as a casualty of a miserable winter Down Under.
But former England captain Flintoff believes it is wrong to single out individuals, and claims it would not have happened in his day.
"The England teams I played in, the buzzword was always the 'group'," Flintoff told the Daily Mail. "That was the mantra, 'The group is close, the group is tight' - and when we were all doing well, that was true. The group stuck together because the group all wanted to take credit for victory and get their column inches in the newspaper.
"But it's when you're not doing well that you need team spirit, and I haven't seen too many people coming out and accepting responsibility for this one. The group doesn't seem to be a group any more. They've got one player who can take the blame and the rest of them want to go about their business and let him take the fall.
"It's not that we couldn't bowl them out, not that we couldn't score runs, not that we got outplayed - it's Kevin Pietersen's fault. I'd have more respect for some of the senior players if they held their hands up, rather than letting it all get heaped on one bloke."
Flintoff claimed players and officials were seeking to defend their own positions by putting the focus on others.
"If his attitude was that bad, why did he play five Tests?" he added. "Who made the decision to drop him? Do they genuinely believe we are better off without him, or are they just fearful for their own jobs and too afraid to say no? I can't imagine what Kevin could have done, or what the ECB could announce, that would allow this to make sense."


text:
Image: Carl Struthers
Carl Struthers in the fish laboratory, 22 August 2011.
- Photographer:
- Mark McGrouther
- Rights:
- © Australian Museum
Carl is from the National Museum of New Zealand, Te Papa Tongarewa. He and Martin Gomon from Museum Victoria visited the Fish Section for two weeks in August 2011.
They worked on a number of projects including examining the morid fishes in the ichthyology collection.
Last Updated:
Tags fishes, ichthyology, visitors, 2011, Carl Struthers,


text: Meat snacks—beef jerky, meat sticks, pork rinds and more—are right at home at U.S. convenience stores. And, despite the rough economy and some sales slippage, new products and popular brands continue to excite customers. Paul Lyons, president and owner of Up North Jerky in Troy, Mich., and a partner, with Sam Kassem and Mike Abdullah,


text:
And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
Let this screenprinted t-shirt rep your love of the Oklahoma City Thunder, OKC's basketball team. Whatever court you find yourself in (OKC or otherwise), you'll be properly outfitted in this t-shirt, boldly scripted with "Thunder" and underscored by a lightning bolt. Each t-shirt is screenprinted with water-based inks that seep right into the fabric for a vintagey look and super-soft feel.
This product ships from the maker within 14 days, via USPS
If you're not happy with this item for any reason, you may return it for a full refund within 14 days.


text:
Jules Bianchi: "I learned a lot during the course of the Chinese Grand Prix weekend. It was a challenging race and in many ways it felt like I crossed the line with a much more complete understanding of the MR02 and the tyres. Although it's still early days, I am really comfortable with my understanding of the car, the direction we are heading in as a Team and where I can continue to develop personally. There's been a nice pace to the season so far, so although we've had just a week before this race, I think it will allow us the chance to consolidate the progress we have made with the interim updates and then catch our breath again ready for what we will bring to Europe. So Bahrain marks the end of the long-haul phase at the start of the season and this is a track I am looking forward to. There are some tricky features and also the conditions make it even more challenging with the high temperatures. It can also be also be quite windy. I've had a bit of experience here in GP2 so it's good to be back and I'm excited to see what we can achieve here."
Max Chilton: "It's good to be heading into Bahrain so soon after China. We ended the weekend there on a more positive note, so I think the short gap between races will be useful in helping us to carry through that momentum. I've raced at the Bahrain International Circuit a few times so I know it to be a great track with quite a few challenging elements to it. It's one of those circuits that seems to be constantly changing through the weekend, so it will be important to get a positive start in Free Practice to provide a good baseline for us to read the rest of the sessions. The updates we brought to China were a good step, so hopefully we can feel more of the benefit of those this weekend. All in all, I'm quite comfortable that things are heading in the right direction now and I'm looking forward to picking up where we left off."
Rodolfo Gonzalez, Reserve Driver: "I'm really happy with this opportunity to drive in my first FP1 session of the season. It will be a nice feeling to be back in a car - especially to drive a Formula 1 car again - and with my previous F1 experience I feel more than comfortable and ready. I love this circuit; it will be quite dusty in FP1 but it's also good fun and I'm looking forward to seeing what I can achieve. I would like to thank the Team for their faith in me. They have made me feel so welcome and have bent over backwards to involve me in every aspect of the racing."
John Booth, Team Principal, Marussia F1 Team: "A quick turnaround for the Team sees us up and running again in Bahrain this week and in good shape overall for the final long-haul race of the early part of the season. This track represents a different challenge from Shanghai but both drivers have raced here before in the junior formulae, so factors like the track conditions - the heat, the wind, the sand - are not a completely unknown quantity for them. From a team point of view we'll need to work hard to achieve the right compromise of car set-up, to manage the grip level and cooling demands. The asphalt can also be quite abrasive here, so it will be interesting to see how the tyre story unfolds here through the weekend. We experienced a few frustrations in Shanghai which we are determined to iron out here so that we give ourselves the opportunity to properly showcase our developments and maintain a clearer picture of where we are in respect to the cars ahead. We are pleased to welcome our Reserve Driver Rodolfo Gonzalez to the car for his first FP1 session of the season. On this occasion he will take over from Jules for the morning but we will see him taking part in this session at several of the races this season and we will alternate between the two cars. We wish him well and look forward to getting our first opportunity to gauge his performance level in the MR02."
Access even more news on Autosport.Register for free to increase your monthly limit from 15 to 25 stories - or subscribe today and get unlimited access.
Subscribe to Autosport Plus
Register for free


text:
Last month 24 miniature horses were rescued from a ranch in the Willits area. Rescuers had hoped to rescue 26, but at least one died before they could intervene. Of those successfully rescued, all but two of the minis have now been adopted; the remaining two are still receiving care.
The sad saga was first brought to the attention of the Mendocino Department of Animal Control nearly three years ago when Anna Arnold became alarmed at the deteriorating condition of a large group of miniature horses on a local ranch. She noticed they did not seem to be getting enough food-especially the mares with foals; several had untreated open sores from fights and their hooves were untrimmed. Arnold called Animal Control to report the neglect. An officer came out and told her the animals had food and water, but he could not force the owners to get them medical care. Arnold said no veterinarian was called.
Arnold continued to monitor the animals, reporting them anonymously to Animal Control as the horses' condition continued to deteriorate. Arnold was reluctant to identify herself for fear of possible retaliation. She did not feel confident Animal Control would protect her identity. Arnold continued to report her observations as the horses' conditions deteriorated further. She knew Animal Control officers came out, but could see no lasting effect from their visits.
"It was horrible," says Arnold, who witnessed a stud killing one of the babies. "The studs were kept together with the mares and the babies."
The horses became even more unkempt; hooves were still untrimmed; and the horses-especially pregnant mares, mares with foals and the youngest horses-were still not getting enough to eat.
Earlier this year Arnold could no longer stand by and watch the minis suffer. The horses were so hungry they were eating their own dung; many had hooves that were crippling the horses; nearly all had eye problems; and some seemed to have upper respiratory problems.
"The poor things were dying," says Arnold. "I could not sit back and watch it. I could not stand the thought of doing nothing."
Arnold started calling Animal Control every day, and then several times a day. After seeing three neglected Laytonville horses receive care following a Facebook campaign, she emailed Mendocino County Sheriff Tom Allman directly on January 23. Allman told her to call Animal Control. Arnold emailed back telling Allman Animal Control was well aware of the situation. Allman promised her he would follow up.
Arnold also enlisted the help of local Willits representatives of Sonoma Action for Equine Rescue.
On February 5 there were 26 mini horses on the ranch when Animal Control called out a veterinarian to examine them. "They are all in good flesh with no signs of disease," was the unnamed veterinarian's report to Animal Control, according SAFER spokeswoman Angie Herman.
The animals weren't rescued until February 8. By then one young white-and-red paint-colored mini horse died of neglect; another had vanished and may also have died.
It took 12 volunteers from the rescue group and all three of the county's animal control officers to actually catch the 24 nearly wild horses for transport to the out-of-county rescue location.
On February 9, a group of Rural Veterinarian Experience Teaching and Service volunteers examined each animal at the refuge. Miniature horses grow long, shaggy coats in the winter. The heavy coats hide most signs of neglect and malnutrition. Veterinarians and mini horse owners know the only way to properly evaluate a mini horse's condition is by a hand's-on examination.
The survivors were examined by the RVET team at the sanctuary. One, named Bison by rescuers, was near death, with a parasitic infection in its lungs. At first veterinarians weren't sure Bison would live, but he has responded to treatment.
One horse was hobbling around on three legs. When vets examined him, they found he had a jagged wire embedded in his flesh, encircling one leg. The wire had been embedded in the horse's leg for a long time.
The vet performed surgery on the spot to remove the offending wire. The horse, along with 15 of his herd mates, also was suffering from nasal discharge, coughing and sneezing.
Many of the horses had long, crippling untended hooves, showing years of neglect.
Two of the horses had a body condition score indicative of extreme neglect and malnutrition.
All had body lice and severe infestations of parasites and worms.
One mare had a dark red, ulcerated mass on her "hindquarters" that required immediate care.
One horse had a tooth abscess draining out through its jaw.
Horses require annual tooth filing to allow them to chew their food. Over time, the uneven wear can make it nearly impossible for them to chew. At least half of the horses had not had their teeth filed for many years.
Handling a rescue of this size involved the assistance of scores of volunteers, including the veterinarians who donated their assistance. Despite the outpouring of support, the cost of medicine and medical testing has pushed out-of-pocket costs above $5,000.
Those who adopted the animals paid a $200 adoption fee to help cover the expenses.
EDITOR'S NOTE: This is Part One of a series on the handling of horse neglect cases in Mendocino County.


text:
New Images and Details...
Sideshow's next Premium Format figure features Marvels vigilante, Frank Castle, aka The Punisher, ready to wage his relentless one-man war on crime.
The Punisher is decked out in a full fabric classic comic design costume with the iconic Deaths Head symbol, and a simulated leather harness with pouches and holster. Sideshow has armed him with an automatic shotgun (AA-12), holstered pistol, and a concealed trench knife.
The Exclusive Punisher Premium Format Figure Classic Costume will include a swap-out sheath and interchangeable left hand gripping the trench knife for close quarters combat.
Both the regular and Exclusive versions of the Punisher Premium Format Figure - Classic Costume will be priced at $359.99.
The Exclusive Punisher Premium Format Figure - Classic Costume will be available for pre-order on Thursday, April 11th, 2013.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, PlasmaInfusion.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


text:
New Undead Entertainment In 2015...
AMC announces that they are in the initial stages of developing a spin-off series to its hit show The Walking Dead. The yet-to-be-titled spin-off series will be executive produced by Walking Dead creator Robert Kirkman, as well as current series team members Gale Anne Hurd and David Alpert.
The new series has a target on-air date of 2015.
"After 10 years of writing the comic book series and being so close to the debut of our fourth, and in my opinion, best season of the TV series, I couldn't be more thrilled about getting the chance to create a new corner of the 'Walking Dead' universe," said Kirkman. "The opportunity to make a show that isn't tethered by the events of the comic book, and is truly a blank page, has set my creativity racing."
Let's hope this new series airs during The Walking Dead's off-season so we get a continuous loop of undead entertainment all year round. How great would that be? It's also a pretty safe bet that we'll see new collectibles, nothing but a good thing for collectors.
Source: msn
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, AlterEgoComics.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


text:
Don't miss out on a lower price on this hotel
Get an overview of this hotel4-star Jeju hotel in Jeju City with 3 restaurants
Collecting Nectar Points
Special Offer: Book by 2 August 2017 and collect double Nectar points!
Simply enter your Nectar card number when you check out. Your points will be credited 35 days after you return from your trip.
*Terms and conditions apply.
Popular property highlights
This hotel is located in Jeju (Jeju City), near the airport, Samsunghyeol Shrine, Folklore and Natural History Museum, and Dongmun Market Place. Also nearby are Jeju NANTA Theatre and Jeju Gwandeokjeong Pavilion.
Hotel Features
This smoke-free hotel features 3 restaurants, a casino, and an indoor pool. Free WiFi in public areas and free self parking are also provided. Other amenities include 2 bars/lounges, a health club, and a coffee shop/café.
Room Amenities
All 282 rooms boast deep soaking tubs and offer free WiFi and TVs. Other amenities available to guests include refrigerators, minibars, and room service.Information missing or incorrect? Tell us!Opens in a new window
Jeju KAL Hotel
Hotel Amenities
Hotel Amenities
In addition to an indoor pool, Jeju KAL Hotel provides a health club, a spa tub, and a sauna. Dining is available at one of the hotel's 3 restaurants and guests can grab coffee at the coffee shop/café. Guests can unwind with a drink at one of hotel's 2 bars/lounges. Wireless Internet access is complimentary.
Business-related amenities at this 4-star property consist of a business center and meeting rooms. 4 meeting rooms are available. This business-friendly hotel also offers a casino, tour/ticket assistance, and an arcade/game room. Complimentary self parking is available on site.
Jeju KAL Hotel is a smoke-free property.
- Conference center
- Tours/ticket assistance
- 24-hour front desk
- Arcade/game room
- Total number of rooms - 282
- ATM/banking
- Number of floors - 18
- Breakfast service
- Number of bars/lounges - 2
- Breakfast available (surcharge)
- Business center
- Casino
- Coffee/tea in common areas
- Coffee shop or café
- Concierge services
- Conference space
- Dry cleaning/laundry service
- Elevator/lift
- Express check-in
- Express check-out
- Casino shuttle (surcharge)
- Gift shops or newsstand
- Hair salon
- Health club
- Free WiFi
- Spa treatment room(s)
- Meeting rooms
- Multilingual staff
- Luggage storage
- Safe-deposit box at front desk
- Free long-term parking
- Free self parking
- Number of restaurants - 3
- Number of meeting rooms - 4
- Sauna
- Shopping on site
- Smoke-free property
- Spa tub
- Steam room
- Indoor pool
- Wedding services
Family Friendly Amenities
- Family Hotel
- Indoor pool
- Free Wi-Fi
- Arcade/game room
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free long-term parking, Free self parking
Room Amenities
- Television
- Desk
- Air conditioning
- Phone
- Refrigerator
- Minibar
- Free bottled water
- Daily housekeeping
- Turndown service
- Private bathroom
- Free toiletries
- Hair dryer
- Slippers
- Shower/tub combination
- Deep soaking bathtub
- In-room safe (laptop compatible)
- Iron/ironing board (on request)
- Free WiFi
- Room service (limited hours)
- Heating
Where to Eat
Buffet breakfasts are available for a surcharge.
Jeju KAL Hotel has 3 restaurants on site.
Room service (during limited hours) is available.
Nearby Things to Do
An indoor pool and a spa tub are on site. Other recreational amenities include a health club and a sauna.
Hotel Policies
Check-in time starts at 2 PM
Check-in time ends at 5:30 AM
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Rollaway/extra beds are available for KRW 35000 per night.
- No pets or service animals allowed
You need to know
Extra-person charges may apply and vary depending on property policy.
Optional extras
- Fee for buffet breakfast: KRW 16500 per person (approximately)
- Rollaway bed fee: KRW 35000 per night
- Facilities fee: KRW 16500 per person and includes use of:
Hotel Name
- Hotel KAL
- Hotel KAL Jeju
- Jeju KAL
- Jeju KAL Hotel
- KAL Hotel
- KAL Hotel Jeju
- KAL Jeju
- KAL Jeju Hotel
- Jeju City Kal Hotel
We should mention
No pets and no service animals are allowed at this property.
National Rating
For the benefit of our customers, we have provided a rating based on our rating system.


text: Ready to pick up the pace By Dave Hickman October 27, 2012 Story Share AP Photo Matt Humphrey averaged 10.3 points last season at Boston College before transfering to WVU. MORGANTOWN - Ask Matt Humphrey what it is that makes him think he will fit perfectly into West Virginia's basketball team and the answer would be a quick one.He likes playing at a fast tempo - running up and down the floor and having the freedom to make things happen."That's what I've been doing my whole life,'' Humphrey said.Strange, though, that he ended up at West Virginia to do that. After all, in recent seasons the Mountaineers have been anything but fast paced.In fact, call them plodding, if you will. These have been WVU teams of late that relied almost entirely on defense to win, attempting to hold the Connecticuts and Syracuses of the world to 65 or 70 points in order to have a chance to score enough to win.Running up and down the floor? Hardly.But that's about to change. Coach Bob Huggins hopes that by the time WVU opens the season in just over two weeks, his once-plodding team more resembles racehorses. Thanks in part to guys like Humphrey, it just might."I like the way Coach Huggs is allowing us to get up and down the floor and play a lot more than he has in the past with different teams,'' Humphrey said. "It's something I'm comfortable with because I have a lot of opportunities to make shots and make plays."That's a big reason why I came here. It's nothing I haven't seen in my journeys.''Humphrey's journeys have been extensive.The 6-foot-5 wing player went from high school in Chicago to Oregon for two seasons. He transferred to Boston College and sat out a year, then played just one season for the Eagles.Now, with diploma in hand (that's the reason he doesn't have to sit out another year) he's preparing to become perhaps the first player - or at least one of the very few - to play in half of the country's six power conferences. "It's been long,'' Humphrey said. "I definitely didn't start out thinking I'd be at West Virginia one day.''It's not that Humphrey hasn't had success along the way. He just hasn't had the kind of success he imagined.During his two years at Oregon, he played in every game but the 12 he missed in the middle of his sophomore season because of a knee injury. He averaged 4.4 points as a freshman and 5.4 as a sophomore. He left there, in part, after Ernie Kent was fired after 8-23 and 16-16 seasons. Humphrey landed at Boston College with new coach Steve Donahue and sat out a year as a transfer. Last season he led the Eagles in minutes and was second in scoring, averaging 10.3 points. But Donahue was in the middle of a rebuilding process and the style of play wasn't exactly up tempo.Having earned his degree and with a year of eligibility remaining, why not uproot again? Humphrey didn't see himself getting any closer to achieving a dream of playing professionally while in a middling program (BC was 9-22 last season) that was in transition.On the surface, it's hard to see anything but a basketball transient. But then when you look at the coaching change at Oregon, the transition going on at Boston College and the college degree already in hand, it's hard to fault Humphrey for his travels. "You get in situations and you do what you've got to do,'' Humphrey said. "You have a dream and you've got to get to it the best way you can. I was in two different situations where I felt it just wasn't [conducive to] my success personally."I'm not trying to take anything away from my teammates there. They were good guys. But I have a dream and I think I'm finally in a place where I'm definitely going to be able to move forward and get some positive things back and hopefully reach my dream.''Perhaps two things stand out when trying to assess why West Virginia is a good fit for Humphrey. First is that style of play that Huggins hopes to implement this season. Humphrey is a shooter who led or was near the top of the 3-point field goal stats for both of his prior teams. Granted, his shooting percentage declined each season - it was just 31.3 percent on 3s last season - but in a faster, more flowing offense the hope is that will change. Humphrey is certainly likely to be given the chance to shoot. One of the reasons the Mountaineers had little in the way of offense last year was a dearth of outside shooters. That should change with Humphrey, freshmen Terry Henderson and Eron Harris and any improvement shown by sophomores like Aaron Brown.The second reason Huggins' program is a fit is because Humphrey is getting much stronger, something the rather lithe perimeter player - he was listed at 185 pounds at Oregon, 195 at BC and now 200 - will need if he ever hopes to play professionally."It's not like I can suddenly jump 10 more inches in the air or something,'' Humphrey said. "But I definitely see the difference in being able to take contact and finish plays better and easier and recover better."I've had two different weight-lifting coaches. Not to knock them, because we got after it both at Oregon and Boston College, but here they just demand a lot more out of you, and it helps and it shows. I've gained weight and I'm getting strong. It helps when it's time to go down there and bang, especially considering more of the frontcourt position I'll be having here.''That's another thing Humphrey will have to adjust to at West Virginia. A team that in recent seasons has been guard poor is suddenly flooded with them. Juwan Staten, Jabarie Hinds and Gary Browne are all more than capable point guards and sometimes two will be on the floor together. And with Aaron Brown, Henderson and Harris there are options at shooting guard.So at 6-5 it's only natural that if someone has to play more of a small-forward role - along with Keaton Miles - it would be Humphrey. The center and power forward positions are well stocked with Deniz Kilicli, Aaric Murray, Kevin Noreen and Dominique Rutledge."The thing that caught my eye is how deep we are,'' Humphrey said. "This is a really deep basketball team. We've got a lot of guys who can play.''Humphrey's biggest drawback is that he's essentially a rookie in Huggins' system. Aside from the three freshmen - 6-10 Volodymyr Gerun is the other - everyone else is a veteran in the system.But Humphrey doesn't see that as a roadblock."I've been here since June 25th and this isn't my first walk in the park as far as offseason work and preseason work and getting into the thick of things with practice,'' Humphrey said. "I'm used to it and I know what I have to do personally and for the team in order to make us better and help guys around me and provide a little bit more leadership that they didn't have in the past because the team was so young last year.''The bottom line is that this is finally Humphrey's last go-around, at his third school. He's played on both coasts and now, in the Big 12, he'll be in the heartland.He can't wait for the chance."It's not like the situations I was in before were horrible,'' Humphrey said. "I just had a lot more downs than ups. I learned a lot of things. I appreciate Coach Kent and Coach Donahue. But I just feel like now I'm in a good place.''Reach Dave Hickman at 304-348-1734 or firstname.lastname@example.com or follow him at Twitter.com/dphickman1. Story Share Story Share Trending Now 1 Police seek car driven by woman found dead in Kanawha River 2 Facebook founder visits Cabin Creek Health Systems 3 Teen pleads guilty to involuntary manslaughter in Oakes Field shooting 4 Man allegedly cuts father in Rand over argument about sandwich 5 Rhode Island bank claims Justice companies owe $4.2M on helicopter loan Dollar cost of WVU's football plummet Previous Story San Francisco sweep -- Giants finish off Tigers in 10 innings Next Story


text:
Already have a List? Sign In
To add alternate formats to your cart, check each of the formats that you want in the list below then click the "Add Selected Items to Cart" button at the bottom of the list.
Ask us about our Custom Book Lists. We can coordinate collections based on interest, reading level, state standards, and more.
Proud member of these professional organizations…


text:
Pretty Much Sold
I've got a stickered-up Innova Discatcher Sport for sale. It's in good shape but the tightener for the base broke off a year ago (see bottom pic). Looking to get $100 and willing travel a bit to deliver (I'm just south of Canton). Click the pic to enlarge.
In all her glory.
These are what good tighteners look like.
Where a tightener should be. Ignore the dirt and webs, they are gone.


text:
Former Detroit Mayor Kwame Kilpatrick has moved into a $309,950 home in Texas, raising questions about the small restitution payments he's making to the city.
Local 4 Defender cameras were in Grand Prairie, Texas, which is not too far from Dallas, and found Kilpatrick's new home. When Kilpatrick first moved to Texas, they lived in a mansion in the posh suburb of Southlake, then moved to a four-bedroom home in Grand Prairieand now to an even larger home.
The Kilpatrick's new residence has over 5,000 sq. feet, five bedrooms, four bathrooms, a granite kitchen and vaulted ceilings. The home was recently listed for $310,000 and would rent for about $2,900.
In Detroit, the former mayor still owes the city more than $800,000 in restitution, but his attorney defends the move to the bigger home. Local 4 Defender Hank Winchester spoke with Kilpatrick's attorney on the phone.
"This is a family of five, what do you want them living in, a one bedroom home? You're living here in Michigan, if you take that house and put it here in Michigan it may be a $2 million home, this is Texas," said Daniel Hajji, Kilpatrick's attorney.
A Dallas based realtor revealed the home Kilpatrick is now living in recently sold, but was unable to name the buyer. His attorney said he believes Kilpatrick is just renting, but said he's not sure if a friend ora family member purchased the home.
Kilpatrick recently worked out a new payment schedule for his restitution saying he can only afford to pay about $160 a month. Under the current plan it would take Kilpatrick about 450 years to pay back the city of Detroit.
Kilpatrick sent Local 4 a statement on the move. "It's true that the new home is bigger, but our costs have slightly improved, and we are working to reduce them even further."
A spokesperson for Wayne County Prosecutor Kym Worthy said the prosecutor's office will be looking into the financial details of Kilpatrick's recent move. Authorities here also want to know why money from Kilpatrick's book is not going into the court ordered escrow account. A hearing on the book profits is set for later this week.
Copyright 2011 by ClickOnDetroit.com. The Associated Press contributed to this report. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Epic Meal Time's latest eye-popping invention features a 21-pound beef patty and a heap of bacon—25 pounds of the stuff, to be specific.
The patty (made with eggs, Montreal steak spice, and barbecue sauce) is double-wrapped in bacon, topped with bacon-wrapped cheddar and bacon wrapped "sauce packs" (mustard and ketchup) and served on a bacon-wrapped bun. On the side, there's a "dictator's dozen" of bacon-wrapped onion rings. Weighing in at a reported 183,886 calories and 15,564 grams of fat, it's something you probably don't want to try at home...though bacon-wrapped onion rings do sound like a good idea.
Take a look at the video below to bask in this glorious/gross culinary creation:
All Bacon Burger - Epic Meal Time
- Video: Chinese Food Burger on 'Epic Meal Time'
- Video: S'mores Burger on 'Epic Meal Time'
- Video: Bakery Burger Combo on 'Epic Meal Time'
- Video: Boss Bacon Burger on 'Epic Meal Time'
About the author: Erin Jackson is a food writer and photographer who is obsessed with discovering the best eats in San Diego. You can find all of her discoveries on her San Diego food blog EJeats.com. On Twitter, she's @ErinJax
Love hamburgers? Then you'll Like AHT on Facebook! And go follow us on Twitter and Pinterest while you're at it!


text:
IT'S really nice down in the West Country at this time of year, or at least it was for myself and around 1,700 Clarets who made the trip to Yeovil on Saturday afternoon.
We just chanced upon the best day in many weeks as the sun shone brightly on a packed open end.
Yet another stunning goal out of nothing opened the scoring, when Danny Ings slammed a cannonball shot into the back of the net.
Sam Vokes celebrated the signing of a new contract by finishing off a perfect cross from the alert Dean Marney, who had intercepted a stray pass from The Glovers.
The last 10 minutes was a bit of a 'harem scarem' finale as Yeovil pressed for a point after pulling a goal back, but Burnley held out to take the maximum reward, which they really needed to if they are to progress.
Being our inaugural visit to Huish Park we had decided to commemorate the occasion in style.
Myself, village mate Pete Read, Brierfield Claret 'plain John Smith', and Walsden based devotee Nigel Stanidge had boarded our travel coach at 9am on Friday.
Our so-called three-night 'cosy break' was at the Wessex Hotel in the village of Street, Somerset, which was just 10 miles from our matchday destination of Yeovil.
With half-board accommodation, nightly entertainment and a couple of excursions thrown in it dovetailed perfectly with our celebration of watching Burnley play on a new ground.
However, there was a drawback as the remaining 38 passengers gave the impression that they were only there to spend their winter fuel allowance on nothing more than rest and recuperation and not rock and roll.
On that basis, we all gave the Sunday afternoon tea dance the swerve, much to the dismay of Smithy, who had claimed to have perfected his foxtrot after watching the DVD box set compilation of Strictly Come Dancing for the past week.
He cheered up a bit at the night time disco and fancy dress, when me and Pete made a dramatic entrance as Batman and Robin in classic Del Boy and Rodney fashion.
Then we all took to the dancefloor.
We won't forget our weekend away in Somerset, and somehow I don't think Somerset will forget us!


text:
Multiple Ascending Dose Study of Miravirsen in Treatment-Naïve Chronic Hepatitis C Subjects
This study has been completed.
Santaris Pharma A/S
Information provided by (Responsible Party):
Santaris Pharma A/S
ClinicalTrials.gov Identifier:
First received: September 9, 2010
Last updated: January 26, 2012
Last verified: January 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The main purpose of this study is to determine the safety and tolerability of multiple dosing of miravirsen in subjects infected with chronic hepatitis C.
Secondary purpose includes assessment of pharmacokinetics of miravirsen and assessment of miravirsen's effect on HCV viral titer.
|Hepatitis C
|Drug: miravirsen Drug: saline
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Official Title:
|A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Ascending Multiple-Dose Study to Assess Safety, Tolerability, Pharmacokinetics and Antiviral Activity of SPC3649 (Miravirsen) Administered to Treatment-Naïve Subjects With Chronic Hepatitis C (CHC) Infection
Resource links provided by NLM:
MedlinePlus related topics: Hepatitis Hepatitis A Hepatitis CU.S. FDA Resources
Further study details as provided by Santaris Pharma A/S:
Primary Outcome Measures:
- Safety and tolerability [ Time Frame: regularly over 18 weeks ]Safety evaluation will study the adverse event (AE) profile, clinical laboratory safety tests, vital signs, 12 lead and ECG monitoring.
Secondary Outcome Measures:
- Pharmacokinetics [ Time Frame: continuously over 4 weeks ]Appropriate PK parameters, e.g. maximum observed plasma drug concentrations, area under the plasma concentration-time curves, the apparent terminal rate constant and corresponding half-life for miravirsen.
- Miravirsen treatment effect on viral titer [ Time Frame: regularly over 18 weeks ]
|Study Start Date:
|September 2010
|Study Completion Date:
|December 2011
|Primary Completion Date:
|December 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: miravirsen
Dose escalation study with review of safety data following each cohort.
Drug: miravirsen
SC injection
Other Name: SPC3649
Placebo Comparator: saline
Dose escalation study with review of safety data following each cohort.
Drug: saline
SC injection
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- BMI 18-38 kg/m2
- Treatment-naïve to interferon-alpha based therapies
- HCV genotype 1
- Clinical and laboratory findings consistent with a clinical diagnosis of CHC, including:
Previous documentation of positive HCV serology (HCV antibody or HCV RNA) at least 24 weeks prior to enrollment, OR Positive HCV serology (HCV antibody or HCV RNA) with a prior remote risk factor (more than 24 weeks prior to Screening) for the acquisition of hepatitis C
- Serum HCV RNA > 75,000 IU/mL at Screening
- (North American sites only). Liver biopsy within 36 months of Day 1, indicating the absence of cirrhosis
- Screening hematology, clinical chemistries, coagulation and urinalysis are not clinically significant and the following criteria are met:
- Platelets >100,000/mm3
- Total WBC > 3000/mm3 and ANC >1500/mm3
- Hemoglobin > 11 g/dL for females and > 12 g/dL for males
- Total and direct bilirubin, WNL (except for clearly documented Gilbert's Syndrome)
- ALT < 5 x ULN
- Serum creatinine WNL and creatinine clearance as calculated by the Cockcroft-Gault formula > 80 ml/min
- Negative results on the following Screening laboratory tests: urine or serum pregnancy test (for women of childbearing potential), hepatitis B surface antigen and human immunodeficiency virus (HIV) antibody.
- For men and women of childbearing potential, willingness to utilize adequate contraception and not become pregnant (or have their partner become pregnant) during the full course of the study. Adequate contraceptive measures include oral contraceptives (stable use for 2 or more cycles prior to Screening). IUD, Depo-Provera, Norplant System implants, bilateral tubal ligation, vasectomy, condom or diaphragm plus either contraceptive sponge, foam or jelly and abstinence.
Exclusion Criteria:
- Other known cause of liver disease except for CHC
- History or symptoms of decompensated liver disease: Child-Pugh Class B or C, including ascites, hepatic encephalopathy, esophageal variceal bleeding, fibrosis or other signs of hepatic insufficiency or portal hypertension
- History of hepatocellular carcinoma (HCC) on imaging studies or serum alpha-fetoprotein (AFP) > 50 ng/mL at Screening
- Concurrent clinically significant medical diagnosis (other than hepatitis C-related conditions) that would potentially interfere with the subjects study compliance or confound study results
- Concurrent social conditions (e.g. drugs, alcohol, transportation) which would potentially interfere with the subject's study compliance
- Clinically significant illness within 30 days preceding entry into the study
- Participated in an investigational drug study within 30 days or 5 half-lives, whichever is longer, prior to the start of study medication.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01200420
Please refer to this study by its ClinicalTrials.gov identifier: NCT01200420
|United States, Texas
|Alamo Medical Research
|San Antonio, Texas, United States
|J.W. Goethe University Hospital
|Frankfurt, Germany, D-60590
|Academic Medical Center (AMC)
|Amsterdam, Netherlands, 22660 1100 D
|Erasmus MC University Hospital
|Rotterdam, Netherlands, 3015 CE
|Klinika Hepatologii i Nabytych Niedoborow Immunologicznych WUM
|Warszawa, Poland, 01-201
|Puerto Rico
|Fundacion de Investigation de Diego
|San Juan, Puerto Rico
|FNsP Bratislava, Nemocnica akad.
|Bratislava,, Slovakia, 833 05
Sponsors and Collaborators
Santaris Pharma A/S
|Principal Investigator:
|Stefan Zeuzem, MD
|J.W. Goethe University Hospital, Frankfurt
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Santaris Pharma A/S:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Ottosen S, Parsley TB, Yang L, Zeh K, van Doorn LJ, van der Veer E, Raney AK, Hodges MR, Patick AK. In vitro antiviral activity and preclinical and clinical resistance profile of miravirsen, a novel anti-hepatitis C virus therapeutic targeting the human factor miR-122. Antimicrob Agents Chemother. 2015 Jan;59(1):599-608. doi: 10.1128/AAC.04220-14. Epub 2014 Nov 10.
Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR. Treatment of HCV infection by targeting microRNA. N Engl J Med. 2013 May 2;368(18):1685-94. doi: 10.1056/NEJMoa1209026. Epub 2013 Mar 27.
|Responsible Party:
|Santaris Pharma A/S
|ClinicalTrials.gov Identifier:
|NCT01200420 History of Changes
|Other Study ID Numbers:
2010-019057-17 ( EudraCT Number )
|Study First Received:
|September 9, 2010
|Last Updated:
|January 26, 2012
Keywords provided by Santaris Pharma A/S:
miR-122 antagonist
host factor
Additional relevant MeSH terms:
Hepatitis A
Hepatitis C
Hepatitis, Chronic
Hepatitis C, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections
ClinicalTrials.gov processed this record on September 21, 2017


text:
Interpretations (0)
Interpret this Dream
Not a member yet? Sign Up Now or Login to your account.
Please note: all interpretations are held for moderation. Sorry, we must fight spam.
Add interpretation anonymously...
59% of the dreams on this site are solved. Submit your dream, we will figure it out.


text:
Penn State honors Krause as Alumni Fellow
The Penn State Alumni Association last month honored Los Altos Hills resident Gay Krause as an Alumni Fellow for her outstanding professional accomplishments.
Krause, a graduate of Pennsylvania State University's College of Education, is executive director of the Krause Center for Innovation (KCI) at Foothill College.
KCI's mission is to design and implement innovative professional development education and training.
Prior to her position with KCI, Krause was a teacher, counselor, assistant principal and principal at Graham Middle School in Mountain View.
She is founder and former chairwoman of the Mountain View-Los Altos Challenge Team, which supports at-risk youth.
With their $6.5 million gift, Krause and her husband, Bill, supported the recently opened Krause Innovation Studio, located on the Penn State campus. The studio helps faculty members support their classes via technology such as digital video, Web 2.0 tools and mobile and ubiquitous computing.


text:
Leeds Carnegie's head coach James Lowes has made four changes to his side to travel to Nottingham on Sunday in the Greene King IPA Championship.
Alex Lozowski returns to the starting line-up and replaces Jonah Holmes at full back, while Craig Hampson starts at scrum half.
In the forwards, Charlie Beech replaces Ben Harris at loose-head prop, while Chris Walker comes in for Ryan Burrows in the back row.
On the bench, there are returns to the squad for James Currie, Jarad Williams, James Doyle and Rob Vickerman after they all missed last week's defeat to Bristol.
Leeds Carnegie: Alex Lozowski; Oli Goss, Jon Clarke, Fred Burdon, David Doherty; Glyn Hughes, Craig Hampson; Charlie Beech, Phil Nilsen, Damien Tussac, Harry Casson, Mike Myerscough, Jacob Rowan, David Sisi, Chris Walker. Replacements: Joe Graham, Lee Imoilek, James Currie, Jarad Williams, James Doyle, James Doherty, Rob Vickerman.


text:
And, of course, the fine print:
Get free shipping on your next order when you spend over $100. The discount will be automatically applied to your purchase; no promo code required. The subtotal of your purchase must be $100.01 or greater after any promotional discounts have been applied. Additional fees such as tax or shipping and handling do not apply toward your minimum subtotal requirement of $100.01. Offer applies to standard shipping only. Certain items that require additional shipping and handling are excluded from this promotion and do not apply towards your $100.01 subtotal minimum. Offer subject to change.
This mason jar cocktail shaker has all the things we love about old-school Americana, plus the ability to mix up a boozy libation or two. It's made of glass, stainless steel and a shot of Southern sensibility. For best results, use often.
- Measures 32 oz.
- Four piece set
- Includes mason jar
- Stainless steel shaker pieces
This product ships from the maker within 4 days, via USPS
If you're not happy with this item for any reason, you may return it for a full refund within 14 days.


text:
Get an overview of this hotel3.5-star hotel with free airport shuttle and restaurant
Popular property highlights
Situated near the airport, this hotel is within 3 mi (5 km) of Diablo Stadium, Grady Gammage Memorial Auditorium, and Arizona State University. Sea Life Aquarium and Tempe Center for the Arts are also within 3 mi (5 km).
Hotel Features
A restaurant, an outdoor pool, and a 24-hour fitness center are available at this smoke-free hotel. Free WiFi in public areas, free self parking, and a free airport shuttle are also provided. Additionally, a bar/lounge, a poolside bar, and a coffee shop/café are onsite.
Room Amenities
All 209 rooms provide conveniences like refrigerators and coffee makers, plus free WiFi and LCD TVs with cable channels. Guests will also find balconies or patios, room service, and premium bedding.Information missing or incorrect? Tell us!Opens in a new window
Sheraton Phoenix Airport Hotel Tempe
Hotel Amenities
Hotel Amenities
In addition to an outdoor pool, Sheraton Phoenix Airport Hotel Tempe provides a spa tub and a 24-hour fitness center. Dining options at the hotel include a restaurant, a coffee shop/café, and a snack bar/deli. Guests can unwind with a drink at one of the hotel's bars, which include a poolside bar and a bar/lounge. A computer station is located on site and wireless Internet access is complimentary.
Business-related amenities at this 3.5-star property consist of a 24-hour business center and meeting rooms. Event facilities measuring 10,000 square feet (1 square meters) include conference space. This business-friendly hotel also offers multilingual staff, gift shops/newsstands, and concierge services. A roundtrip airport shuttle is complimentary to guests (available 24 hours). Onsite self parking is complimentary.
Sheraton Phoenix Airport Hotel Tempe is a smoke-free property.
- 24-hour fitness facilities
- Number of buildings/towers - 1
- Outdoor pool
- Spa tub
- Concierge services
- Breakfast available (surcharge)
- Bar/lounge
- Conference space
- Meeting rooms 10
- 24-hour front desk
- Porter/bellhop
- Express check-out
- Multilingual staff
- Safe-deposit box at front desk
- ATM/banking
- Gift shops or newsstand
- Dry cleaning/laundry service
- Television in common areas
- Elevator/lift
- Free airport transportation
- Total number of rooms - 209
- Number of floors - 4
- Smoke-free property
- Free WiFi
- Shared microwave
- Luggage storage
- Restaurant
- Long-term parking (surcharge)
- Conference space size (meters) - 1
- Snack bar/deli
- Free self parking
- Coffee shop or café
- Free newspapers in lobby
- Fireplace in lobby
- Computer station
- Poolside bar
- Number of meeting rooms - 10
- 24-hour business center
- Conference space size (feet) - 10,000
- Free use of nearby fitness center
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Free Wi-Fi
- Snack bar/deli
- Refrigerator
- Microwave (on request)
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Long-term parking (surcharge), Free self parking
Room Amenities
- Free cribs/infant beds
- Premium TV channels
- Pay movies
- Video-game console
- Premium bedding
- Balcony or patio
- Room service (limited hours)
- Air conditioning
- In-room climate control (air conditioning)
- Free weekday newspaper
- Phone
- Refrigerator
- Coffee/tea maker
- Free bottled water
- Free toiletries
- Hair dryer
- Iron/ironing board
- Cable TV service
- Hypo-allergenic bedding available
- Microwave (on request)
- Free WiFi
- In-room safe (laptop compatible)
- Daily housekeeping
- Private bathroom
- Shower/tub combination
- Connecting/adjoining rooms available
- Rollaway/extra beds (surcharge)
- Desk
- Blackout drapes/curtains
Where to Eat
Full breakfasts are available for a surcharge and are served each morning between 6 AM and 11 AM.
Fire and Spice - This poolside restaurant specializes in local cuisine and serves breakfast, lunch, dinner, and light fare. Guests can enjoy drinks at the bar. A children's menu is available. Happy hour is offered. Open daily.
Room service (during limited hours) is available.
Nearby Things to Do
An outdoor pool and a spa tub are on site. Other recreational amenities include a 24-hour fitness center.
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- In-room accessibility
- Accessible bathroom
- Roll-in shower
Hotel Policies
Check-in time ends at 11:30 PM
Check-in time starts at 3 PM
Minimum check-in age is 21
Special check-in instructions:
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Rollaway/extra beds are available for USD 30.00 per night.
- Free cribs (infant beds)!
- Pets allowed for an extra charge of USD 75 per accommodation, per stay, plus a USD 75 deposit
- Up to 70 lb
You need to know
Extra-person charges may apply and vary depending on property policy.
- The name on the credit card used at check-in to pay for incidentals must be the primary name on the guestroom reservation.
Optional extras
- Breakfast fee: between USD 6.00 and USD 13.00 per person (approximately)
- Pet deposit: USD 75
- Pet fee: USD 75 per accommodation, per stay
- In-room microwave fee: USD 10
- Rollaway bed fee: USD 30.00 per night
Hotel Name
- Sheraton Phoenix Airport Hotel Tempe
- Sheraton Phoenix Airport Tempe
- Sheraton Tempe Phoenix Airport
- Sheraton Tempe
- Tempe Sheraton
- Sheraton Phoenix Airport Hotel
- Sheraton Phoenix Airport
We should mention
This property offers transfers from the airport. Guests must contact the property with arrival details before travel, using the contact information on the booking confirmation. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.