text: 602121 1 Johns Hopkins Ion Channel Center JHICC_KCNQ1_Act_SAR_IWS_2 2012 12 6 SAR analysis for compounds that activate KCNQ1 potassium channels in the KCNQ1 expressing cells on automated patch clamp 2 Data Source: Johns Hopkins Ion Channel Center (JHICC_KCNQ1_Act_SAR_IWS_2) BioAssay Type: Confirmatory, Concentration-Response Relationship Observed Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening Center PI: Min Li, Ph.D. Assay Provider: Meng Wu, Ph.D. Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R03 MH090837-01 Grant Proposal PI: Meng Wu, Ph.D., Johns Hopkins University School of Medicine Assay Implementation: Haibo Yu Ph.D., Kaiping Xu M.S., Owen McManus, Ph.D., Meng Wu Ph.D. Description: Voltage-gated potassium channels [1,2] are tetrameric membrane proteins that selectively conduct K+ across cellular membranes, thus open, close, and inactivate in response to changes in transmembrane voltage [3]. Individual subtypes of these potassium channels often have a unique expression pattern allowing cells to "fine-tune" membrane potentials and excitability according to their respective physiological functions [4]. Dysfunctions of these electrical excitability controlling proteins, either congenital or acquired, are attributed to a variety of diseases [5,6], such as cardiac arrhythmias, diabetes, hypertension, and epilepsy. Specific modulation of individual potassium channel types therefore represents an enormous potential for the development of physiological tool compounds and new drugs [7-9]. KCNQ1 (Kv7.1, KvLQT) [10,11] is an alpha-subunit subtype of voltage-gated KCNQ potassium channel family, which is composed of five members of KCNQ1-KCNQ5. They share between 30% and 65% amino acid identity. A classical KCNQ alpha-subunit is composed of six transmembrane segments, including a voltage-sensor segment and a pore domain [12-15]. Unique from other members of KCNQ family [16], KCNQ1 has been generally absent from neuronal tissues, mainly expressed in heart, kidney, small intestine, pancreas, prostate and other non-excitable epithelial tissues. Also contrast to other members of KCNQ family which form both alpha-subunit homo- and heterotetrameric channels, KCNQ1 channels only form alpha-subunit homotetramers [10]. They commonly co-assemble with beta-subunit KCNE proteins to give rise to functional variations in different tissues. These molecular assemblies have afforded KCNQ1 with two important physiological functions: 1) repolarization of the cardiac tissue following an action potential and 2) water and salt transport in epithelial tissues. Mutations in this gene are associated with hereditary long QT syndrome, diabetics [18], Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome [19] and familial atrial fibrillation [20], as well as impairment of cyclic AMP-stimulated intestinal secretion of chloride ions related to cystic fibrosis [21,22] and pathological forms of secretary diarrhea [23-25]. Furthermore, drug-induced acquired KCNQ1 and KCNQ1/KCNE dysfunctions also raise concerns of KCNQ1/KCNE as potential hERG-like drug safety issue in pharmaceutical development [17]. For their pharmacological responses, KCNQ1/KCNE heteromultimers function differently from KCNQ1 alone. Initial discovery of KCNQ1 modulators is focused on the KCNQ1 (and KCNQ1/KCNE1 IKs) inhibitors [17]. In contrast to KCNQ1 channel blockers, only until recently have KCNQ1 channel activators/ potentiators been generating a lot of interests partially due to KCNQ1/KCNE activators might be useful agents to counteract the loss of delayed rectifier function in LQT syndromes, as well as counter target of other KCNQ family members for potential drugs for the treatment of epilepsy and neuropathic pain. Overall there are a very limited number of KCNQ1 activators/ potentiators, a further limited number of KCNQ1/E1 heteromultimer-specific modulators, and no reported KCNQ1/E2 or KCNQ1/E3 heteromultimer-specific modulators. This has hindered a more systematic study to understand the roles of on beta-subunits. Therefore it justifies the necessity of primary high throughput screen of KCNQ1 with the MLSMR library of >300,000-500,000 compounds covering large chemical space. Principle of the assay Patch clamp recording provides a high resolution, linear measure of channel activities. The purpose of this assay is to test the SAR compounds for KCNQ1 activators using automated population patch clamp electrophysiology system IonWorks (Molecular Devices). This assay employs automated patch clamp (Ionworks Quattro) to investigate the current responses of KCNQ1-CHO elicited by voltage clamp protocols in the presence or absence of test compounds. Compounds were tested in quadruplicates at varying concentrations Keywords: KCNQ1, activator, agonist, Concentration Response Curve, JHICC, Johns Hopkins, Molecular Libraries Probe Production Centers Network, MLPCN. References: 1. Gutman, G. A., Chandy, K. G., Grissmer, S., et al. International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels. Pharmacol Rev 57(4), 473-508 (2005) PMID: 16382104 2. Dai, S., Hall, D. D., and Hell, J. W. Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels. Physiol. Rev. 89(2), 411-452 (2009) PMID: 19342611 3. Borjesson, S., and Elinder, F. Structure, Function, and Modification of the Voltage Sensor in Voltage-Gated Ion Channels. Cell Biochemistry and Biophysics 52(3), 149-174 (2008) PMID: 18989792 4. Pischalnikova, A., and Sokolova, O. The Domain and Conformational Organization in Potassium Voltage-Gated Ion Channels. Journal of Neuroimmune Pharmacology 4(1), 71-82 (2009) PMID: 18836841 5. Peroz, D., Rodriguez, N., Choveau, F., et al. Kv7.1 (KCNQ1) properties and channelopathies. The Journal of Physiology 586(7), 1785-1789 (2008) PMID: 18174212 6. Cannon, S. C. Physiologic Principles Underlying Ion Channelopathies. Neurotherapeutics 4(2), 174-183 (2007) PMID: 17395127 7. Ahern, C. A., and Kobertz, W. R. Chemical Tools for K+ Channel Biology. Biochemistry 48(3), 517-526 (2008) PMID: 19113860 8. Wulff, H., and Zhorov, B. S. K+ Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases. Chemical Reviews 108(5), 1744-1773 (2008) PMID: 18476673 9. Wickenden, A. D. K+ channels as therapeutic drug targets. Pharmacology & Therapeutics 94(1-2), 157-182 (2002) PMID: 12191600 10. Jespersen, T., Grunnet, M., and Olesen, S.-P. The KCNQ1 Potassium Channel: From Gene to Physiological Function. Physiology 20(6), 408-416 (2005) PMID: 16287990 11. Mackie, A. R., and Byron, K. L. Cardiovascular KCNQ (Kv7) Potassium Channels: Physiological Regulators and New Targets for Therapeutic Intervention. Mol Pharmacol 74(5), 1171-1179 (2008) PMID: 18684841 12. Maljevic, S., Wuttke, T. V., and Lerche, H. Nervous system KV7 disorders: breakdown of a subthreshold brake. The Journal of Physiology 586(7), 1791-1801 (2008) PMID: 18238816 13. Robbins, J. KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacology & Therapeutics 90(1), 1-19 (2001) PMID: 11448722 14. Hernandez, C. C., Zaika, O., Tolstykh, G. P., et al. Regulation of neural KCNQ channels: signalling pathways, structural motifs and functional implications. The Journal of Physiology 586(7), 1811-1821 (2008) PMID: 18238808 15. Delmas, P., and Brown, D. A. Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 6(11), 850-862 (2005) PMID: 16261179 16. Brown, D. A., and Passmore, G. M. Neural KCNQ (Kv7) channels. British Journal of Pharmacology 156(8), 1185-1195 (2009) PMID: 19298256 17. Towart, R., Linders, J. T. M., Hermans, A. N., et al. Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening? Journal of Pharmacological and Toxicological Methods 60(1), 1-10 (2009) PMID: 19439185 18. Jonsson, A., Isomaa, B., Tuomi, T., et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes, 58(10) 2409-13 (2009) PMID: 19584308 19. Schmitt, N., Schwarz, M., Peretz, A., et al. A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J 19(3), 332-340 (2000) PMID: 10654932 20. OMIM. http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=607542 (2009) 21. Namkung, W., Song, Y., Mills, A. D., et al. In Situ Measurement of Airway Surface Liquid [K+] Using a Ratioable K+-sensitive Fluorescent Dye. J. Biol. Chem. 284(23), 15916-15926 (2009) PMID: 19364771 22. Moser, S., Harron, S., Crack, J., et al. Multiple KCNQ Potassium Channel Subtypes Mediate Basal Anion Secretion from the Human Airway Epithelial Cell Line Calu-3. Journal of Membrane Biology 221(3), 153-163 (2008) PMID: 18264812 23. Schroeder, B. C., Waldegger, S., Fehr, S., et al. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403(6766), 196-199 (2000) PMID: 10646604 24. Greenwood, I., Yeung, S., Hettiarachi, S., et al. KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells. Pflugers Archiv European Journal of Physiology 457(4), 785-794 (2009) PMID: 18663467 25. Matos, J. E., Sausbier, M., Beranek, G., et al. Role of cholinergic-activated K Ca 1.1 (BK), K Ca 3.1 (SK4) and K V 7.1 (KCNQ1) channels in mouse colonic Cl - secretion. Acta Physiologica 189(3), 251-258 (2007) PMID: 17305705 Protocol for automated patch clamp on KCNQ1-CHO cells with voltage clamp 1. Cell culture: Cells are routinely cultured in DMEM/F12 medium, supplemented with 10% Fetal Bovine Serum (FBS), 50 IU/ml penicillin, 50 ug/ml streptomycin, and 500 ug/ml G418 by using 150mm dishes. 2. Split cells once they reach 80% to 90% confluence 2.1. Aspirate medium from culture, add 10 mL of PBS (without Ca2+ and Mg2+) to wash the cell monolayer. 2.2. Aspirate the PBS. 2.3. Add 5 mL of 0.05% Trypsin to the 150mm dish, leave dish undisturbed for 3~5 min at 37 to trypsinize the cells. 2.4. Add 20 mL of growth medium to neutralize the digestion of Trypsin. 2.5. Transfer cell suspension to 50 mL falcon tube and spin at 750 rpm for 4 min. 2.6. Remove supernatant and resuspend cells with 6 ml external solution, spin down at 450 rpm for 4 min. 2.7. Count the cells, adjust the cell density at 2x10;6 per ml. 3. Prepare 3x compound plates: test compounds are prepared using external solution; 4. Prepare Amphotericin B: dissolve 5 mg Amphotericin B with 180 uL DMSO, vortex for 1 min; transfer dissolved amphotericin B to 50 mL internal buffer, fill in the amphotericin B tube. 5. Fill the external solution in the buffer boat; fill the internal solution in the internal solution bottle. 6. Add the cells in the cell boat. 7. Load the protocol: The holding potential is -70 mV. To elicit the currents, cells were stimulated by 2,000 ms depolarizing step from -70 mV to +40 mV. Start the experiments. 8. Measure the currents at the steady state. +40mV was used to evaluate compounds. 9. Calculate the percentage of current change for tested compounds with the following formula: Percentage (%) =100* (Current (post-compound)-Current (pre-compound))/Current (pre-compound) Percentage (%): Percentage of current inhibition observed after the application of the test compound. Current (pre-compound): Current recorded before the test compound application Current (post-compound): Current recorded after the test compound application 10. Outcome assignment If the test compound causes activation effect on KCNQ1 in any concentrations tested and the dose response is generated, the compound is considered to be active. If the test compound does not cause activation effect on KCNQ1 in any concentrations tested or a dose response is not generated, the compound is designated as inactive. 11. Score assignment An inactive test compound is assigned the score of 0. An active test compound is assigned the score of 100. 12. Internal buffer (40 mM KCl, 100 mM K-Gluconate,1 mM MgCl2, 2 mM CaCl2, 5 mM HEPES, pH 7.25) 13. External buffer (137 mM NaCl, 4 mM KCl, 1.8 mM CaCl2, 1 mM MgCl2, and 10 mM HEPES and 10 mM Glucose, pH 7.4) 2648 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channels 493007 Validation assay for identification of compounds that potentiate KCNQ1 potassium channels 2699 Summary of assays for compounds that potentiate/activate KCNQ1 potassium channels http://www.jhicc.org 3784 KCNQ1 potassium voltage-gated channel, KQT-like subfamily, member 1 [ Homo sapiens ] 1 EC50 mean EC50 of compound inhibition of on KCNQ1 1 5 2 EC50 SD Standard deviation of mean of EC50 1 254 3 N number of repeats for EC50 of compound inhibition 2 254 4 Hill constant Hill constant 1 254 5 Hill constant SD Standard deviation of Hill constant 1 254 6 0.014uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 0.0140000004321337 5 1 7 0.014uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 8 0.041uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 0.0410000011324883 5 1 9 0.041uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 10 0.12uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 0.119999997317791 5 1 11 0.12uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 12 0.37uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 0.370000004768372 5 1 13 0.37uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 14 1.11uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 1.10000002384186 5 1 15 1.11 uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 16 3.33uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 3.29999995231628 5 1 17 3.33 uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 18 10uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 10 5 1 19 10 uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 20 30uM-Percentage% % Percentage for KCNQ1 at the specified concentration 1 254 30 5 1 21 30 uM-SD Standard Deviation of measurement for % Percentage at the specified concentration 1 254 1 potassium voltage-gated channel subfamily KQT member 1 [Homo sapiens] 32479527 1 Homo sapiens human taxon 9606 potassium voltage-gated channel subfamily KQT member 1 [Homo sapiens] 2 1 CR Plot Labels 1 Concentration Potentiation Percentage 0 1 R03 MH090837-01 2


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Cooper hopes for changes in collision rule
CHICAGO -- Pitching coach Don Cooper was at home watching the White Sox and Giants on television Wednesday afternoon, dealing with the effects of vertigo, when he witnessed the overturn of a seventh-inning play at the plate go against the White Sox and spark a seven-run frame for San Francisco.
The overturn was based on Rule 7.13, protecting the catchers from a home-plate collision, and catcher Tyler Flowers was called for blocking the plate without the ball even though Gregor Blanco was out by a sizeable margin.
Cooper immediately screamed at the television in disbelief and continued his anger on Friday with a diatribe on the matter.
"That rule has got to be changed. It's ridiculous," Cooper said. "The whole thing about getting replay is to get the play right. They had the thing right. He's out by 10 feet. That's going to be tweaked I'm sure.
"They took a game from us as a team and they [messed with] our pitcher. I'm not in favor of either one of those things. They need to figure that out."
Manager Robin Ventura, who followed an ejection with a classic dirt-kicking reaction on home plate, was calm and in good spirits during his pregame media session Friday. He joked about hearing from numerous people about his Lou Piniella-like reaction, adding that his kids loved his response.
But don't confuse his calm demeanor with an acceptance of that call.
"I know what the spirit of the rule is supposed to be with protecting catchers and taking care of them," Ventura said. "It's gone a little bit beyond that."
The White Sox manager believes this rule will be tweaked, much like the transfer rule, if not removed completely.
"You still have to see the play and allow the catcher some freedom to move around," Ventura said. "I don't necessarily think they can look at two things at once either. But I think if a guy is going to be out, he's going to be out. You have a pretty good idea of that when you see the play.
"Otherwise, I think if you take it too far, you're probably at a point where you might as well make it a force play at home like you do at first. It would clean up everything."
Scott Merkin is a reporter for MLB.com. Read his blog, Merk's Works, and follow him on Twitter @scottmerkin. This story was not subject to the approval of Major League Baseball or its clubs.

subset: commoncrawl


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Five of the seven school districts in Geauga County presented levies to their districts' voters in Tuesday's election.
Of those, levies in the Chardon, Ledgemont and Newbury districts� failed, according to unofficial final results. Cardinal's renewal levy clearly passed while West Geauga's landed slightly ahead in an extremely tight vote count. The district must wait 10 days for provisional votes to be counted before claiming official passage.
"We're cautiously optimistic, that's the best phrase we can use," said West Geauga Superintendent Geoffrey Palmer. "I think the committee and everybody worked hard to try to get the message out. We want to thank the community for coming out and steadying the ship operationally over the next few years."
The unofficial final vote was 4,944 to 4,894in favor of the five-year 2.75-mill additional levy for permanent improvements. Approximately 90 percent of funds are earmarked for replacement of deteriorating roofs in the district's buildings.
A Chardon School District 5.95-mill continuing additional levy met with rejection with unofficial final results of 6,091 to 5,692.
Superintendent Joseph Bergant, who is serving his final year with the district, said he was obviously disappointed but proud of the work the committee did in significantly closing the gap from past elections.
"The new superintendent will have a pretty daunting task ahead," he said. "I'm worried the state is going to come through with additional cuts."
He noted that cuts planned in case of levy failure would now be implemented and that some notifications of layoffs would be made in March. Reductions in the amount of $814,231 are scheduled to be made in order to end the 2012-13 school year in the black.
Bergant also referred to the negative effects the levy failure would have on the Chardon community.
"It'll take a few years to get there, but mark my words, you dismantle public education and you dismantle the community," he said.
Ledgemont voters delivered a negative message to the school district with the rejection of a five-year, 3.4-mill additional levy by a vote of 1,185 to 1,070.
The district has been in
fiscal emergency since
2010 and is working toward emerging from the negative status.
Because the levy failed, the district will be mandated to adopt minimum operating standards which includes fewer curriculum offerings, transportation cuts and more costly pay-to-play athletics.
Numerous repairs on buildings in the Newbury School District will not be addressed as a result of the failure of a five-year 3.0-mill levy, rejected by unofficial final results of 1,185 to 1,070.
An outdated heating and cooling system, football stands in disrepair, and the deterioration of bricks and walls in the high school were among several reasons levy money was requested.
Cardinal School district's 9.7 mill renewal passed by an unofficial vote tally of 2,566 to 1,877.


text: OverviewBack to top Green Sprouts - Organic Cotton Socks Newborn 0-6 Months Grey - 1 Pair Item# :103142UPC# :715418023212 Brand:Green Sprouts Size/Form:1 Pair Green Sprouts Organic Cotton Socks (Newborn 0-6 Months) Solid Grey 3 1/2" x 5 1/2" Green Sprouts Organic Cotton Socks are warm and cozy. Green Sprouts Organic Cotton Socks coordinate with other Green Sprouts organic layette items. Green Sprouts Organic socks are made of organic cotton/spandex. Green Sprouts Certified Organic Cotton socks are hypoallergenic and chemical free. aGreen Sprouts Organic Cotton Socks are comfortable next to baby's skin. Green Sprouts Organic Cotton Socks are available in numerous colors including white, sage green, conflower blue, salmon, rose pink, bamboo, and grey. Green Sprouts Organic Cotton Socks are also available in various sizes including Newborn (0-6 Months), Infant (6-18 Months), and Toddler (2-4 Years). Green Sprouts Layette. Pure Fun. Pure BabyGreen Sprouts has been making playwear for babies from natural fibers for over 25 years. Green Sprouts's layette items are made from thick, breathable cotton so that little ones can play comfortably. Outside BabyWhile the first priority is ensuring that what babies put in their mouths is safe, it is also important to protect young children from exposure to harsh chemicals in their external environment that can be absorbed through their skin or inhaled through their mouths and noses. As children grow older, Green Sprouts believes they should begin learning healthy fitness habits early through yoga and active play - both indoors and out! Organic CottonGrown without the use of toxins, synthetic fertilizers or persticides, organic cotton is the safest, healthiest fabric available - especially for allergy-sensitive babies. Green Sprouts's organic cotton is produced without harsh chemical bleaches and is tested to ensure the absence of metal contaminants. Green Sprouts uses low-impact dyes for the health and safety of babies and the environment.


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By Sean Arnold
Staff writer
Williston graduate Austin Langworthy culminated a five-run ninth inning for No. 10 Florida with a three-run double last Thursday in Nashville, helping his Gators to a 10-6 come-from-behind win over No. 6 Vanderbilt.
The hit, which was sliced into the left-field corner, marked Langworthy's first in 13 at-bats against left-handed pitchers on the season.
Copyright © 2017
The Williston Pioneer is your source for local news, sports, events, and information in Levy County and Williston, Fl, and the surrounding area.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Monday, September 25, 2017
Athletic Training
Do Doctors Sleep During Foot Class?
My cat hit my foot Apr 2 leaving me with 2 or 3 stress fractures in L foot. I was put in a boot after 8 days, told to ice, elevate, exercise and after 6 weeks, "just walk on it." In July saw a dr in another state, he put it in a cast for 3 weeks, "no no don`t walk on it". Then, a lace up brace and just walk on it...baby steps. It is now Oct and still swells, throbs, hurts from toes to mid-calf and the more I try to `walk on it` with help from a walker..the more it swells and the more it hurts. Will I ever get my foot back?
I am sorry to hear of your ongoing troubles with your foot. Since I am unsure which type of physician you have previously seen, I would recommend a visit to a orthopedic physician who specializes in foot and ankle care to further evaluate your problem. They can determine if you have any additional issues, and if there are other treatment options for your pain and limitation given the length of time you have been experiencing symptoms. Good Luck!
Janine Oman, MS, PT/ATC
Assistant Athletic Director
Instructor at the School of Health and Rehabilitation Sciences
College of Medicine
The Ohio State University


text:
Durable Printable Cord Tags
Avery Blank Templates Microsoft Word
Use this template for an easy way to tell which cord is which.
Compatible Products:
Reviewed by 1 customer
This review is from AVERY Durable Printable Cord Tags:
I have tried to come up with a good setup for this product (6591). The Microsoft Word template opens in a "profile" orientation, and cannot be flipped to "landscape" at least not with Microsoft Office 2010 in Windows! Printing from the online application is never in sync with the label as it prints. It seems to always be off, not centered or prints partly on the wrapping portion of the label!


text:
Keep Storm Drains and Sanitary Sewer Lines Flowing
Fairfax County Office of Public Affairs
12000 Government Center Parkway, Suite 551
Fairfax, VA 22035-0065
Contact: Merni Fitzgerald, Director of Public Affairs
703-324-3187, TTY 711, Fax 703-324-2010
Media Pager: 703-324-NEWS (6397)
March 5, 2008
Tips for Homeowners for
Keeping Storm Drains and Sanitary Sewer Lines Flowing
While cleaning gardens for spring, residents should keep public storm drains and sanitary sewers clear of leaves, grass clippings, sticks, rocks and trash. Fairfax County officials are issuing this reminder because these items can cause blockages in storm drains and sewers.
If swept into a storm drain, yard waste or trash can end up in nearby creeks or steams, polluting the environment. These same items can block public sanitary sewer lines, potentially causing sewage backups in homes.
Residents also can take steps to keep their private sewer lines flowing freely. Homeowners are responsible for their lateral sewer lines, which connect their home to the county's sewer system. These tips can help prevent blockages:
- Don't put cooking oils and grease down a garbage disposal or any household drain. Fats, oils or grease can build up in the system, potentially creating a blockage.
- Don't flush disposable diapers, tampons or sanitary napkins down the toilet — even if the labels indicate that it is acceptable to do so.
Most insurance policies do not automatically cover damage caused by flooding or sewer backups. Homeowners and renters can contact their insurance companies to ask for this additional protection.
If homeowners experience a sewage backup, call Fairfax County's Wastewater Collection Division's 24-hour, emergency line at 703-323-1211, TTY 703-239-8498. For non-emergency concerns, call 703-250-2003, TTY 703-239-8489. County staff can determine if the blockage is located in the county's sewer lines or in the homeowner's private lines.


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Apple (AAPL) blogger Horace Dediu has retweeted a very interesting ILike.Code post about how Microsoft (MSFT) is about to cede the console gaming market to Apple in very short order.
Dediu's post explains how Microsoft has really squandered an opportunity with Xbox over the past two years. On paper, Microsoft's decision over a decade ago to get into the console gaming market looks brilliant. While Sony (SNE) and Nintendo (NTDOY) have stumbled badly, Microsoft has -- to date -- sold 76 million Xbox units worldwide.
Not only has this led to a huge profit stream to Microsoft from some amazing games, it more importantly gave Microsoft a huge advantage getting a foothold in the connected homes of the future. While Apple, Amazon (AMZN) and Google (GOOG) were dreaming about a "Connected Home" strategy, Microsoft had gotten to an enormous installed base number who had HD-compatible, Internet-connected, DVD-playing and software-update-compatible consoles. From that starting point, Microsoft could have really used that as a springboard to get into a whole host of Internet services and enhanced TV.
But Microsoft has rested on its laurels. It continues to rely on new video games coming out to juice sales and hopes that innovations like Kinect are enough to excite people to do more with their machines. Other than that, you can always run Netflix (NFLX) on Xbox. That hasn't been enough.
There are two other big problems pointed out in the blog post.
The first is complex load times reminiscent of your worst memories of Windows, with inexplicable delays and cryptic messages. Why wait when you can play a game on your iPad?
The second big problem is the fact that small developers can't easily build new games and then promote them on the Xbox platform. You would think that having 76 million Xbox consoles out there would be attractive to new developers to sell their innovative games to. But it's too bureaucratic to get games even posted to the Xbox platform, and even harder to get them in front of people so they might consider buying them. As a result, the only people producing games on the Xbox platform are the established game makers.
Dediu speculates that as soon as Apple launches its iTV later this year, any game developer will be able to follow the 30% App model to get "console-like" games running on Apple TV. Here's a great quote: "The current numbers already say a lot, even with Apple-TV not already an open console: 5.3M sold units in 2012, 90% year-over-year growth -- vs. Xbox 360 -- about 9M units in 2012, 60% YoY decline."
Maybe it's not too late for Microsoft. It just bought Blake Krikorian's "Connected Everything" startup R2 Studios. Maybe it tosses the keys to him and gives him the freedom to look at everything with new eyes.
But Microsoft is squandering a golden opportunity.


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Right Red, a female penguin who turns 32 years old on Feb. 16, is the 15th oldest penguin out of 2,000 African penguins living in U.S. zoos, according to records of the International Species Inventory System (ISIS).
Another member of the flock, a male named Left Plum, turned 30 years old on Jan. 30, making him the 30th oldest penguin in a U.S. zoo. (Our penguins are named for the color and location of bands worn on their wings.)
What does old age look like for a penguin?
"Right Red has arthritis, and she receives meds to control pain," says zookeeper Kasey DeLucenay. "She also has trouble molting (shedding old feathers), so she looks a little scruffy."
Right Red and her mate, Left Red, who died in 2011, were devoted to one another and raised three chicks together. "They had a very strong bond with each other," says DeLucenay.
As a birthday treat, Right Red and Left Plum received a towering "cake" made of fish and ice, which they shared with the rest of the flock. A big thank you to the zookeepers who provide excellent care to our "elderly" penguins!Did you make a New Year's resolution to get more involved in your community? The zoo is the place for you! Check out these upcoming opportunities:
*Volunteer Opportunity Fair, 6-7:30 p.m. Feb. 8, http://kidszoo.org/events/volunteer-opportunity-fair/.
*Z-TEAM Teen Volunteer & Leadership Program, application deadline is Feb. 28, http://kidszoo.org/support-the-zoo/volunteering/teen-volunteers/.
*FrogWatch Training, 11 a.m. -3 p.m., http://kidszoo.org/support-the-zoo/volunteering/family-and-group-volunteering/.
*Zoo Employment: See job openings and information on our upcoming Job Fair, which will be held March 9, at http://kidszoo.org/about-the-zoo/employment-opportunities/.


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OKOLONA – In a dogfight for the school's first district baseball title in 10 years, veteran North Bullitt skipper Brian Wise went into his bag of surprises.
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Chippenham Rotary Club is inviting golfers to take to the fairways in April for its annual golf classic and charity auction, which will raise funds for Dorothy House Hospice Care.
The event, on Thursday, April 10, is the club's ninth golf classic day. It takes place at the Manor House Golf Club, Castle Combe, and is suitable for any level of player.
The course is considered to be one of the finest in the south west and was created in 1992 by BBC commentator Peter Alliss and his design partner Clive Clark.
Rotarian and event organiser Jerry Dix said "We are indebted to this incredible list of supporters and, of course, to the loyal band of golfers who come back each year."
Entry forms for this four-player team event are available from www.chippenham rotary.org or call Dorothy House on (01225) 721480.
The closing date for applications is April 3 and the fee is £50 per player.


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Anybody left that still thinks Rick is a great X's and O's coach?
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Anybody left that still thinks Rick is a great X's and O's coach?
If we're talking tic tac toe... otherwise, not after tonight
I'm already on record as saying that this should be Ricks last season here in Indiana...
I don't think he's a bad coach... I just feel like his tenure as the Pacers head coach has run it's course and it should be over when this season is finished. Sure he's been dealt a bad hand having to deal with some of the nutjob players that have worn the blue and gold these past few years.... but even considering that, I still think it's time for a different direction coaching wise.
This game should have been won. We lack the understanding of how to close out a game, at home of all places?!?!?! I think TINS is playing great of late, but not sure if he should be taking the last shot, but I wasn't able to watch the game, so not sure the game situation. But I could see by checking the score on my phone that we were going to lose. Don't know what else to say, but get it together, you are playing at HOME! I know that these are Westeren Conference teams, but come on, play hard and close these teams out in the forth. SOmeone in our locker room should be screaming right now, these are important games... 3 steps forward and then two back, same Pacers.
Nice game tonight by many of our players, but it means nothing without that W.
Avatar photo credit: Bahram Mark Sobhani - AP
I don't understand Rick's belief in end-of-quarter/half/game situations being the time to give the ball to the PG and just expect him to pull something out of his ***, with the possible addition of a pick.
very tired of him, but I know he is a good coach.
Avatar photo credit: Bahram Mark Sobhani - AP
Can we lay to rest the idea that Tins does the driving and such on his own account ?
So Long And Thanks For All The Fish.
If you've done 6 impossible things today?
Then why not have Breakfast at Milliways!
But in these situations? I don't blame him at all.
Sure was fun to watch a game without Jermaine O'Neal. Love that style of play where we're only in it because we're unconscious from deep.
This space for rent.
2 losses to the Sonics in the final secs... a good team would have found a way to win ONE of those games. Maybe we need to get healthy, maybe we need a new coach, maybe we need an overload.... after 2 straight home lossed to below .500 teams.... WE NEED SOMETHING!
Ok, I've read the first 9 posts and no one has even mentioned the word Defense. That is why the Pacers lost. Blame Rick all you want for JT missing that final shot, but the defense is what killed us tonight.
it is really as simple as that
I thought Tinsley played well tonight - he was a more willing passer and he was able to get into the paint which is where I want him shooting from. No three point shots please.
I do need to say that Watson, a player I've wanted for 3 season now, looked impressive to me
You think it's HIS fault that nobody moves on this team??????????????
I mentioned defense some in the game thread.. too angry to include it here!
I agree Tinsley played well, I didn't even notice he was 10-26 from the field. Any other night I think I would have know Tinsley shot 26 times, but his all around game blacked out how many times he shot.
I'm not blaming Rick for JT missing a shot, I'm blaming Rick for coming up with an ill-conceived, predictable play on a potential gamewinning shot. Was it inevitably Rick that caused us to lose? absolutely not those lob-passes and alley-oops and uncontested layups finally caught up with us. But you have to admit that last play was beyond wretched.
He opened the 3rd by running sets designed to get Murphy the 3pt look, that worked well. He also was calling the play that kept getting DA the open 3 in the corner. Didn't hear a lot of fan complaints about that one.
And he had his 2 best rebounders in the game to pull in that Ray Allen miss and the Tinsley miss. Too bad they didn't get the defensive board and couldn't put the offensive board in at the other end. Either play would have won the game. Regardless, he had his best rebounders in the game for those 2 situations.
Amen. I saw motion. I saw confused, unsure of where guys were supposed to be motion, but they were moving. I vote that any style where your all-star player gets the ball most of the time is good.Sure was fun to watch a game without Jermaine O'Neal. Love that style of play where we're only in it because we're unconscious from deep.
For all the rips on Tins (and he did force the 2nd half action into the toilet when it came to his shooting), he had to tell several players where to be when they were trying to run that DA 3pt look play yet again. He called it and no one setup right. He shook his head in disgust and redirected them. The play then ran perfectly except that Foster got nailed with the moving screen (late 4th).
It's not as simple as Rick or Tinsley. Players are confused, probably due to the massive roster changes that get worse when your star player is out.
And you guys that rant about JO's passing (which is quite good now, even statistically), watch Ike freak out in the post when he has to move the ball. He struggled to pass out of the post all night.
One thing about that final call, how did the Pacers regain the lead just a minute earlier? Exactly.
Heck, how did Granger and Murph and DA get those open 3s? Tins starting plays is NOT WRONG. Calling Tins number to work inside isn't wrong. Ray Allen was asked to do it all night too. The problem came when he forced the play beyond where it should go. At some point you have the option to pass depending on how the play is defended.
Rick tried a lot of different sets and kept adjusting all night looking for something that would work. He ran the hell out of those Murph and DA for 3 sets (those were set plays with several stages before the shot, which is why they looked identical every freaking time) because they were working.
The fact is this team lost Quis, lost JO, and traded down from Jack to DunDun. They were an iffy offensive team before and its worse now even when Quis and JO are out there. The defense from Dun is very questionable, Murph is hit and miss.
Fixing the attitude came at a price, one this roster wasn't really in a position to afford.
If it makes you feel better, this will probably end Rick's tenure here. And then it will get really ugly. Good news for all you lottery is magic fanatics, it's probably a season away.
I don't know how Granger missed the put back a very similar shot to the one he missed at the end of the Mavs game.
I missed the first half of the game, but from what I saw, Dunleavy did a decent job on Allen. It wasn't the disaster I would have predicted.
Yes it was. Wasn't it in the 2nd half when DunDun fell on Ray while trying to keep up with him (Gnome laughed out loud when it happened)? That was the closest to staying in front of him he could muster all night.I missed the first half of the game, but from what I saw, Dunleavy did a decent job on Allen. It wasn't the disaster I would have predicted.
Ray hit some tough shots against Danny and did get by him once. But at least DG was able to stay in front of him most of the time. And I've been critical of DG's 1 on 1 defensive smarts. Tonight DG was solid.
I need to see more evidence before I can draw any conclusions. But I'm a little concerned about Diogu's defense. He seems to almost have Harrison-itis. I'm reserving judgment - but it is somehting I'll be watching closely
Harrison's D has been decent this year... all 5 minutes of it.
This space for rent.
Yes it was the same shot and it worked earlier, but the phrase "going to the well one too many times" comes to mind. Like I said...it was predictable. regardless of whether or not it worked on play X does not mean it will work on play Y that's flawed logic.
These post game threads are 100% reactionary. If we win I know that I'll see certain guys saying how great the team is. If we lose I know I'll see other guys coming on to remind us we need to fire the coach and how bad the team is. Bottom line is we were playing without our All-star, Ray Allen had a great game, and we still had 3 or 4 looks at the basket to win the game.
UB you are write about the defense, we failed to make adjustments in team D tonight with JO sitting, no doubt it was a factor.
I am not that troubled by losing by a FG without the Pacers star. I am mire worried about why every game the Pacers start out flat and spot the other team a lot of points,
ok anybody with an IQ of 2 could have made that callHe was smart enough to get craptastic Dunleavy out of the game and off of Ray Ray and put Granger on him. That cut the damage.
ok he ran a few set plays still nothing groundbreaking.He opened the 3rd by running sets designed to get Murphy the 3pt look, that worked well. He also was calling the play that kept getting DA the open 3 in the corner. Didn't hear a lot of fan complaints about that one.
Again an obvious coaching move i've seen people on this board wonder why he has kept his rebounders out of the lineup in the closing minutes, he finally made that adjustments after about 3 games good for him.And he had his 2 best rebounders in the game to pull in that Ray Allen miss and the Tinsley miss. Too bad they didn't get the defensive board and couldn't put the offensive board in at the other end. Either play would have won the game. Regardless, he had his best rebounders in the game for those 2 situations.
These last two games have been very disappointing. The Sonics put forth a lot of effort, and the Pacers played pretty hard, so I can't complain about that.
Still, we're not improving as a team. The reason we made the trade was to avoid these ups and downs. And after an impressive 4 game streak, we've come back and lost to a team in the 5th game of a 6-game road trip and then to a team that lost 15 consecutive road games.
I just don't know what to expect out of this team.


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Character and Star AnagramsLanguage brain teasers are those that involve the English language. You need to think about and manipulate words and letters.
For the following clues, you will relieve a jumbled set of letters, which when unscrambled, will lead to a famous movie character and the actor/actress who played them.
The hint will give the number of letters for the character and the initials for the star.
1. Screen jab annoys demon
2. Leo drowns in weak tastes
3. Fedora raids no Johns in Iran
4. Info man hunts drama fin
5. For rank, cop is a nice pal
Hint1. Character (5,4) Star (S C)
2. Character (4,6) Star (K W)
3. Character (7,5) Star (H F)
4. Character (4,3) Star (D H)
5. Character (5,7) Star (A P)
Answer1. James Bond- Sean Connery (James Bond series)
2. Rose Dawson- Kate Winslet (Titanic)
3. Indiana Jones- Harrison Ford (Indiana Jones series)
4. Rain Man- Dustin Hoffman (Rain Man)
5. Frank Serpico- Al Pacino (Serpico)
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"'It certainly was a focus of ours to try and cover off the center position in this draft," Regier said. "In Grigorenko's case, his skill level and play-making ability is exceptional. In Girgensons' case, he's a very good playmaker and has a physical component to his game. So I think they complement each other."'
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Gov. Mark Dayton has appointed long-time DFL State Sen. Larry Pogemiller as the new head of Minnesota's Office of Higher Education.
Dayton's first choice for the cabinet level position resigned in September after only nine months on the job.
Pogemiller said the governor had to convince him to take it. The prospect of leaving the Legislature after serving for three decades is tough, he said.
"I love it dearly as an institution, and the people," he said. "I'm going to miss it."
Pogemiller said the governor told him with new leaders taking the helm at the University of Minnesota and the Minnesota State Colleges and Universities system this summer, and with the state struggling to fund colleges while dealing with its own budget problems, now is the time for the leader of the Office of Higher Education to step and be a solid advocate for the state's colleges.
"I think this is a wise move for me personally and I hope the governor has chosen wisely and I hope to live to his expectations," he said.
The Office of Higher Education might not be a household name, but it plays a big role in managing the state's portion of financial aid for students. It writes checks for $150 million in aid every year.
It also cranks out a lot of data about enrollment and how well students are doing, which the state's higher education leaders use to make decisions.
Pogemiller expects to start work as early as next week. His departure from the Legislature means Dayton will need to call a special election to fill his seat. The state Senate will eventually have to confirm Pogemiller's appointment when it reconvenes next year.
He said he's confident he'll be voted in. But Republican Sen. Michelle Fischbach, who heads the higher education committee that will take up Pogemiller's appointment, said it's too soon to know what kind of reception he'll get.
"We're much too early in the process to determine whether or not that would be the case. Obviously we have committee hearings and a floor process, the entire process that the Senate goes through," she said.
One DFL lawmaker expressed surprise on Twitter when news of the announcement came out.
State Rep. Mindy Greiling of Roseville thought Sen. Sandy Pappas, a former chair of the senate's higher education committee, was a better fit for the job. She ended her Tweet with the question, "Too female?". If Pogemiller is confirmed, there will be 19 men on Dayton's cabinet, and only six women.
"The governor is hobnobbing more with men more than women recently and so this would've been a good place to have a strong woman be in place, another woman to work with him," Greiling said.
For her part, Sen. Pappas said she would have left the Legislature after nearly 28 years to take the higher education commissioner's job.
But Pappas said she doesn't have any hard feelings against Pogemiller.
"Sometimes you and your friend are in competition and the better person wins," she said. "I just wish him the best of luck."
Meanwhile, the question remains how the Office of Higher Education got to the point of needing another leader.
Sheila Wright, the dean of education at Hamline University in St. Paul when Dayton appointed her to the higher education position last January. She resigned nine months later after a low-profile tenure. It's unclear if Wright was asked to leave the job.
Wright couldn't be reached for comment.
Pappas said Wright just wasn't a good fit for the job, and wasn't comfortable with either the management involved, or the political nature of the position.
Pogemiller said that's something that won't bother him, and thinks his experience as a politician could come in handy in the commissioner's position.


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The FAA continues to investigate why the main entry door separated and fell from a Challenger 601-3R–registered as N207JB and owned by Medcp [sic] Aviation–as it was climbing through 3,000 feet after taking off from Opa-locka (Fla.) Airport on Wednesday afternoon. According to an FAA preliminary report, "the door separated…under unknown circumstances." The twinjet's two crewmembers did not sustain any injuries; there were no passengers on board at the time.
Just two minutes after departing Opa-locka at about 3:45 p.m. for what appears to be a 20-minute repositioning flight to Pompano Beach (Fla.) Airpark, the crew declared an emergency after losing the door. They then diverted to Fort Lauderdale-Hollywood International Airport, where they landed safely.
The aircraft's main entry door fell mainly intact, with its airstair still attached, before hitting the 16th fairway of the Westin Diplomat Resort & Spa's championship golf course near Hallandale Beach. The course was reportedly closed at the time of the incident. No one on the ground was injured by the falling door, which landed with such force that it bounced 15 feet after initial impact. A Bombardier spokeswoman told AIN that the Challenger 600-series main entry door weighs 285 pounds.
Hugh Jard (not verified)
May 30, 2012 - 5:08pm
the correct spelling for the name of the airport, and the adjacent city, is Opa-locka. There is no upper case "L" in the name.
R. Randall Padfield
May 31, 2012 - 11:35am
Thanks for noting the error in the spelling of "Opa-locka." This has been corrected in the story.


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LEXINGTON, Ky. -- What we learned as Kentucky stormed through an extra five minutes and earned an essential 90-83 overtime victory over new SEC rival Missouri on a raucous Saturday evening at Rupp Arena:
UK is not starting over
A prominent NCAA Tournament bracket analyst -- Joe Lunardi of ESPN -- has been saying in radio interviews that Kentucky essentially started at 0-0 when it visited Tennessee for last Saturday's road game, its first following the knee injury that ended the season of freshman star Nerlens Noel.
That's simply not true.
Kentucky is not 2-1. Kentucky is 19-8 overall and 10-4 in SEC play. There certainly is an emphasis on these last several games. For the Wildcats to make the NCAA Tournament, they must show they still are a proficient team without Noel. But the Selection Committee understands it is not reasonable to assume that Noel was the only reason the Wildcats won the games they did before his injury, and it will carry that understanding into deliberations in a couple of weeks.
It also will carry the memory of this game, in which the Wildcats rallied from a 13-point first-half deficit and made numerous clutch plays in overtime. Included was a sizzling baseline cut by freshman guard Archie Goodwin that opened him for a feed from point guard Ryan Harrow; Goodwin's layup gave UK an overtime lead it never surrendered.
UK shooting guard Julius Mays made four consecutive foul shots to seal the game, giving him a team-high 24 points.
The Wildcats still have a huge game at Arkansas, which has been nearly impossible to beat at Bud Walton Arena, as well as a season-ending visit from Florida and the SEC Tournament. Whether they are an NCAA team will be established in those games, in part because they hadn't proven it before Noel was injured.
There's still time for Poythress
Every now and then we've seen these signs from UK freshman forward Alex Poythress: the home game against LSU, the second half at Ole Miss. But mostly he has played as though trapped in some sort of dream sequence from "Inception."
Before Saturday night, Poythress had played six games in February and hadn't reached double-figures once, not even in the two after the injury to Noel made more minutes and touches available. Even through all of that, he was projected as a lottery pick by DraftExpress.com, which shows those folks have the stamina of a champion triathlete.
Even with this game, he still doesn't look like he belongs on anyone's 2013-14 NBA roster, but Poythress played like he wants to be part of the 2013 NCAA Tournament, certainly.
When Poythress drove the right baseline and powered in a layup with 5:59 remaining, Poythress was 8-of-9 from the field and had 19 points and seven rebounds. He finished with 21 points and only missed one more shot.
Bowers is finding his form
Since returning from a knee injury that knocked him out of five midseason games, Missouri power forward Laurence Bowers has not been as productive as early in the season.
He was an All-American level player before the injury, with four double-doubles and only one game of fewer than 11 points. Since his return, Bowers had attempted double-figure shots only twice, and in one of those went 1-of-10 from the field.
Bowers isn't the star he was before getting hurt, but in the first half against Kentucky he was quietly efficient, ringing up eight points on 3-of-5 shooting and contributing five rebounds and a steal. He finished the game with 13 points.
His catch-and-finish on a fast-break layup with 13:12 remaining was the work of a gifted athlete and basketball player. His recovery to the Laurence Bowers that began the season remains the most important element of Mizzou's March potential.
Oriakhi can score
Sometimes the "what we learned" designation can be misleading. Sometimes it's more like "what was amplified." This deep into a season, we're not seeing these teams for the first time. We know a lot by now.
This truly is something we learned, though, Saturday night.
Alex Oriakhi put 22 on Ole Miss a couple weeks ago, but the Rebels are 75th in the nation in defense efficiency, so that might not have been the best measure. He has been more the player who entered with three consecutive single-figure games, the guy who only had attempted 10-plus shots four times all season.
And yet by the 12:40 mark of the second half, Kentucky had to double-team Oriakhi when he caught the ball in the post.
For a player with an NCAA championship ring -- he was an integral part of that championship Connecticut won in 2011 -- Oriakhi has been something of a maddening player. He has the body of an NBA power forward and sometimes even the game, but often as not his attention to detail has drifted. He admitted as much as the 2011 Final Four, and that was when he was playing his best.
Oriakhi finished Saturday night's game with 16 points and 15 rebounds. If he performs like this the next several weeks, Mizzou's NCAA Tournament could last a good bit longer than last year's.
UK's other issue
Who's missing is not the Wildcats' only problem. Against a team ranked 54th in defensive efficiency, Kentucky operated at essentially a point-per-minute pace for the first 16 minutes.
The Wildcats missed all seven of their 3-point attempts in that stretch, and only Harrow and Poythress even were able to score. The other five rotation players were a combined 0-for-10 from the field.
When the Wildcats finally ran a low-post set to forward Kyle Wiltjer out of the four-minute timeout, he bounced it a couple times to draw a defender away from Mays. His 3-pointer became the first UK basket not scored by Harrow or Poythress and brought UK back to a 28-22 deficit. That seemed to change the evening for the Kentucky offense -- and particularly for Harrow, who broke out of a funk and began facilitating a sold offensive attack.
The Wildcats ended the game shooting 50.8 percent from the field, and Harrow had 16 points, six assists and only two turnovers. Oh, and eight rebounds, too.
He's still Phil Pressey
With 35 seconds left in the half and Kentucky down 32-27, Harrow soft-pedaled a drive attempt that might have been successful if transacted more aggressively, and Pressey pulled down the offensive rebound.
We repeat: 35 seconds.
If anyone in the building is supposed to know time/score at that point, it's the guy in charge of the offense. The play at that point is, almost without exception, to hold the ball for the final shot attempt of the half. At worst, Mizzou would have been ahead by five. At best, it might have been up by eight.
Instead, Pressey raced to the opposite end of the floor, attempted a layup and watched it roll off the rim. Wiltjer rebounded and was fouled almost immediately, then made the two free throws.
Well, it wouldn't be a Pressey sequence if he didn't squeeze in something heroic, so he answered those foul shots with a top-key 3-pointer. But he did it early enough -- officially with nine seconds remaining -- that Kentucky was able to zip the ball upcourt for a fast-break dunk by Willie Cauley-Stein.
So the net result of Pressey's miscalculation was Kentucky headed to its locker room down only 35-31. Given the circumstances, the Wildcats couldn't have asked for much better.
Pressey has a short memory, though. He just moves on.
Pressey's two second-half 3s were both essential in keeping the Tigers in contact. He also ran a pick-and-roll with Oriakhi at the 3:08 mark that should be the illustration on a coaching tape of how to run the pick-and-roll, executed a perfect fast-break dump-off to Bowers that cut the deficit to a basket and then stole the ball right from Goodwin's hands in the middle of the UK lane, dashed to the opposite end and fed wing Keion Bell for a layup that tied the game at 71-all. His fast-break layup with 55.2 seconds remaining put Mizzou in front by a bucket.
And in overtime, we saw again what can happen to Pressey at the end of a game. Inside the final minute, he had the ball on the right wing and gave up his dribble, then jumped to launch an ill-advised shot, only to lose his grip and then try to recover with a wild pass to no one in particular. The ball rolled toward midcourt, where it was collected by Poythress, who drove until fouled. His two free throws made it 83-79 UK.
There is no one quite like Pressey. That is for certain.


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To understand how the NFL tilts its rules in favor of the offensive players, take the case of Broncos linebacker Von Miller.
On the first play of the game Sunday at Carolina, an unsuspecting Miller was pursuing a screen play when he got blown up on a blindside hit by receiver Steve Smith. The official initially threw a flag against Smith for unnecessary roughness on a defenseless player, but then thought better of it.
No penalty. Why? Was it partially because Miller is a linebacker?
Now it's toward the end of the game. Miller was on a pass rush, got knocked to the ground, crawled and wrapped his arms around quarterback Cam Newton's legs near the ankles. Another Broncos players hit Newton high, but Miller got the penalty for roughing the passer.
Not only did Miller get penalized for hitting below the quarterback's knees, but the league fined him $21,000 Thursday. Miller said he will appeal.
"How am I supposed to know if he threw the ball or not?" Miller said. "I was down on the ground — actually the guard facemasked me and threw me into the quarterback. I'm supposed to what? Stand straight up and continue with the tackle?"
Another Broncos defensive player, Kevin Vickerson, was fined $15,000 for his horsecollar penalty while sacking Newton.


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Solid Tumors Using Ixabepilone and Dasatinib
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Patients are being asked to take part in this study because they have been diagnosed with an advanced solid tumor that is not responding to standard treatments. This study will find the highest dose of ixabepilone and dasatinib in combination that can be given without causing severe side effects.
Both ixabepilone and dasatinib have individually been tested in many (several thousand) patients, however the combination of the two drugs has not yet been tested in humans.
All patients who will take part in this study will receive combined drug therapy of dasatinib and ixabepilone. Dasatinib is a pill that is taken by mouth. Ixabepilone is a medicine that will be given by vein (IV).
All participants will receive ixabepilone by vein once every three weeks as well as dasatinib by mouth once daily.
|Solid Tumor
|Drug: ixabepilone Drug: Dasatinib
|Phase 1
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase I Study of Ixabepilone Combined With Dasatinib in Patients With Solid Tumors
- The primary outcome is to determine the safety and toxicity of ixabepilone and dasatinib in combination in patients with metastatic or locally advanced/unresectable solid tumors that have progressed through standard therapy. [ Time Frame: From study start until completion of study followup. This can vary greatly between patients, but on average patients received treatment for 4 cycles (12 weeks). ]While on the drug combination, patients will be seen in the clinic every 3 weeks. These visits will assess the safety and tolerablility of the drug regimen. The drug combination continues until disease progression or unacceptable toxicity. When one of those two events occurs, the patient enters the followup phase. During the followup phase, the patient will return to the clinic every 4 weeks until drug-related toxicities resolve.
- The secondary outcome is to evaluate tumor response as a preliminary assessment of clinical activity. [ Time Frame: From start of the study until completion of the drug regimen. This can vary greatly between patients, but on average patients received treatment for 4 cycles (12 weeks). ]Disease status will be monitored via diagnostic imaging every other cycle (every six weeks) until the patient is finished with drug combination. The drug combination continues until disease progression or unacceptable toxicity.
|Study Start Date:
|July 2008
|Study Completion Date:
|May 2011
|Primary Completion Date:
|May 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
All participants will receive ixabepilone by vein once every three weeks as well as dasatinib by mouth once daily. All participants will receive the study drugs at a baseline dose. If the side effects are minimal and tolerable, the next cycle of study drugs will be given at same dosage. If side effects are intolerable, then the dose will be lowered.
Drug: ixabepilone
by vein once every 3 weeks
Other Name: ixempraDrug: Dasatinib
by mouth once daily
Other Names:
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Have a solid tumor malignancy that is metastatic or locally advanced/unresectable
- Progression through standard therapy
- Histological documentation of cancer
- Must be off prior chemotherapy or radiation therapy for at least 3 weeks
- Must have adequate organ and marrow function prior to the start of study treatment as defined by the protocol
- Must be able to swallow oral medication (dasatinib must be swallowed whole)
- Must be available for protocol-required follow-up
Exclusion Criteria:
- Patients with a malignancy (other than the one treated in this study) which required radiotherapy or systemic therapy within the past 5 years
- Symptomatic brain metastasis that is either untreated or uncontrolled by surgery and or radiotherapy
- A known, prior, severe (NCI CTC Grade 3/Grade 4) history of hypersensitivity reaction to a drug formulated in Cremophor (polyoxyethylated castor oil)
- A serious, uncontrolled medical disorder or active infection including pericardial or pleural effusion of any grade,uncontrolled or significant cardiovascular disease,a bleeding disorder.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00717704
|United States, District of Columbia
|Washington Cancer Institute
|Washington, District of Columbia, United States, 20010
|Principal Investigator:
|Sandra M Swain, MD
|Washington Hospital Center
|Responsible Party:
|Washington Hospital Center
|ClinicalTrials.gov Identifier:
|NCT00717704 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 15, 2008
|Last Updated:
|May 29, 2012
Keywords provided by Washington Hospital Center:
Malignant solid tumor
Phase 1
Dose escalation
Metastatic or locally advanced/unresectable
Disease progression through standard therapy
Additional relevant MeSH terms:
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
ClinicalTrials.gov processed this record on September 25, 2017


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The University of Colorado Boulder will hold its winter commencement ceremony on Friday, Dec. 16, in the Coors Events Center on campus.
The ceremony will begin at 9:30 a.m. and is free and open to the public.
Due to traffic delays and the possibility of adverse winter weather, early arrival is strongly advised. Guests should plan to be seated by 9 a.m. People entering the events center are asked not to bring large purses or bags to the ceremony.
During the ceremony, 2,171 degrees will be conferred. Degrees to be awarded include 1,593 bachelor's degrees, 414 master's degrees, 150 doctoral degrees and 14 law degrees.
The commencement address will be given by Harvey Segur, a CU-Boulder professor of applied mathematics and this year's recipient of the Hazel Barnes Prize, the highest faculty recognition for teaching and research awarded by the university.
Segur has been a CU-Boulder faculty member since 1989. Recognized for his highly cited and influential research on nonlinear waves along with his exceptional teaching record, Segur is helping to transform undergraduate education at CU-Boulder, focusing on improved student performance in lower-division calculus. He has received the Boulder Faculty Teaching Excellence Award, is a President's Teaching Scholar and gave the 2005 Distinguished Research Lecture.
City and campus roads may be congested for approximately one and a half hours before the ceremony and about an hour afterward. Parking lots and gray meters near the Coors Events Center are free for commencement parking. Traffic officers and parking supervisors and attendants will be available to assist campus visitors.
Additional information about commencement, including a campus parking map and information for people with disabilities, is available at www.colorado.edu/commencement/. The website also will feature a live webcast of the ceremony on Dec. 16.


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Hi. We moved systems, and because it was impossible to achieve feature parity between the systems, we opted to archive the old B&S threads but allow users to read them so that they can put them into our new B&S system.
There is a support thread if you have any issues.
Any Opinions On This?
Discussion in 'B&S Archive' started by bachbeet, Sep 23, 2006.


text: Holliday adjusting to offensive explosion By Doug Smock October 2, 2012 Story Share HUNTINGTON - Marshall coach Doc Holliday wants his offense to put up the big numbers, score a lot of points. He hired coaches and recruited athletes to accomplish that goal, and it's starting to pay off.The Thundering Herd is 2-3 but has scored 205 points, an average of 41.0 per game. Let's put that in perspective: Marshall did not score 41 in any one game through the 2008, 2009 and 2010 seasons, plus the first eight games of 2011, a span of 45 games.That dike has been unplugged, but the water is flowing both ways. Marshall has been hit with 69 points by West Virginia and 51 by Rice and Purdue.Then again, the offenses are getting the upper hand nationwide. The nation is still buzzing over West Virginia's 70-63 scorefest with Baylor.It has Holliday's head buzzing, too. He may have coached offensive positions for years, but he is a former linebacker and still likes a little good defense.Right?"I look around the country today. You know, Texas probably has as good of players as anybody on defense," Holliday said. "You look up and, all of a sudden, Oklahoma State with a backup quarterback scores 36. Don't tell me that West Virginia and Baylor don't have some pretty good defensive players, and it's 70-63."What's happening in college football today is just amazing to me. Tommy Shuler, against a Big Ten team that's picked to maybe play for the championship, has 19 catches for 200 yards; they can't match up. They don't have enough players to match up with those three- and four-wide sets at times, and it creates issues for them."I think everybody's going through some growing pains defensively around the country, of trying to match up with what's happened to the offenses. You've got to catch up quick - I still believe in my heart that you win championships playing great defense. When we're sitting here having our last press conference, you're probably going to see the Alabamas of the world, people who are playing great defense, playing for championships." There have been a few track meets in Conference USA. Houston and Rice lost to Louisiana Tech by scores of 56-49 and 56-37; Rice turned around and tied Marshall at 41 at the end of regulation before falling 54-51; Marshall fell to Purdue 51-41.And while that last game was transpiring, Tulsa was sweating out a 49-42 win over Alabama-Birmingham at Legion Field.The Golden Hurricane remains Conference USA's leader in total defense, but it showed its high-risk, high-reward characteristics. UAB quarterback Austin Brown was sacked seven times but pulled off several big passes - including a 75-yard touchdown pass on the game's first play from scrimmage."They gave up some big plays. They missed tackles, gave up a couple of big plays they don't normally give up," Holliday said. "And they turned the ball over a couple of times, had a blocked punt that gave UAB a short field, starting from the plus-5-yard line. And I tell you, UAB's got some players now."And there's that tempo thing. Marshall's 92.4 scrimmage plays per game lead the country, but seven of the nation's top 10 offenses are squeezing off more than 80 snaps.That is negating schemes and leaving defenses winded and frustrated. That helped Marshall get back within striking position against Purdue, and could help the Herd knock off Tulsa at home on Saturday. "If you can line up, if you can make the proper read and hit the proper 'hot' [receiver], if you can protect, you've got a shot," Holliday said. "Against UAB last week, [Tulsa] gave up some big plays."Reach Doug Smock at 304-348-5130 or email@example.com. Story Share Story Share Trending Now 1 Facebook founder visits Cabin Creek Health Systems 2 Safety shutoff disabled prior to June coal-mining death, report says 3 Huggins, WVU tap South Florida hoops talent 4 Teen pleads guilty to voluntary manslaughter in Oakes Field shooting 5 Congressional opioid investigation targets drug wholesaler Miami-Luken GW girls knock Hurricane from unbeaten ranks, 3-2 Previous Story Doc: Tulsa's more physical than finesse Next Story


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The State of the Union is the opposite. The president gives a performance, extremely animatedly, head swiveling from left-side prompter to right-side prompter, continually urging action now: "Let's start right away. We can get this done. … We can fix this. … Now is the time to do it. Now is the time to get it done." And at the end of the speech, nothing gets done, and nothing gets fixed, and, after a few days' shadowboxing between admirers and detractors willing to pretend it's some sort of serious legislative agenda, every single word of it is forgotten until the next one.
In that sense, like Beyoncé lip-synching the National Anthem at the Inauguration, the State of the Union embodies the decay of America's political institutions into a simulacrum of responsible government rather than the real thing, and a simulacrum ever more divorced from the real issues facing the country. "Over the last few years, both parties have worked together to reduce the deficit by more than $2.5 trillion," said the president. Really? Who knew? "Now we need to finish the job." Just one more push is all it'll take.
What's he on about? The annual "deficit" has been over a trillion for every year of Obama's presidency. The cumulative deficits have, in fact (to use a quaint expression), increased the national debt by $6 trillion. Yet Obama claims Washington has "reduced the deficit" by $2.5 trillion, and all we need to do is "finish the job." Presumably this is a reference to allegedly agreed deficit reductions over the next decade, or quarter-century or whatever. In other words, Obama has saved $2.5 trillion of Magical Fairyland money, which happily frees him up to talk about the really critical issues like high-speed rail and green energy solutions. These concepts, too, exist mainly in Magical Fairyland: if you think Obama-approved taxpayer-funded "high-speed rail" means you'll be able to board a train that goes at French or Japanese speeds, I've a high-speed rail bridge to Brooklyn to sell you.


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DETROIT -- Chris Webber was ineligible when he played basketball in high school because of his relationship with a former University of Michigan basketball booster, which violated his amateur standing, the state's governing body for high school athletics has ruled.
The Michigan High School Athletic Association's executive committee said Sunday that Webber was ineligible during the time he played at Birmingham Detroit Country Day. But it left it up to the school to decide whether to forfeit games in which Webber played, including three state championship titles.
The association's executive director has urged the school to forfeit the championships it won with Webber.
"I think they should do it [forfeit the titles]," Jack Roberts, executive director of the MHSSA, told the Detroit Free Press. "I've said it at the first, second and third meetings with them that they should voluntarily forfeit the contests and return the team championships and get it over."
A message seeking comment from Roberts was left Monday.
Martin, who died last year at the age of 69, said he gave Webber and his family $280,000 from 1988-93, a period extending from his freshman year of high school through his sophomore season at Michigan. Webber left for the NBA after helping the Wolverines reach the NCAA title game in both of his college seasons.
Webber, who plays for the Sacramento Kings, was sentenced to community service last summer after pleading guilty to criminal contempt for lying to a grand jury about his dealings with Martin.
Webber was suspended without pay for eight games by the NBA on Feb. 17 for violating its drug policy and for pleading guilty to lying to a grand jury. He is eligible to return to the Kings lineup Tuesday vs. the Los Angeles Clippers.
A message seeking comment from Webber's agent was left Monday.
Country Day officials, who appeared before the executive committee Wednesday, disagreed with the MHSAA that Webber's amateur standing was violated. A spokesman for the Oakland County school said Monday that the school was studying the situation and reserving comment, possibly until a news conference later Monday or Tuesday.
Martin gave $616,000 in illicit benefits to Webber, Robert Traylor, Maurice Taylor and Louis Bullock -- who all starred at Michigan. Based on investigations by the government, the NCAA, University of Michigan, the Big Ten Conference and others, the MHSAA found that Webber and Traylor violated amateur status rules.
Officials from Detroit Murray-Wright, where Traylor played high school basketball, voluntarily forfeited every game won during Traylor's senior season. Murray-Wright won the Class A state championship in 1994, Traylor's junior year, but no link to Martin was found until his senior year.
The MHSAA could force Country Day to forfeit its titles, but Roberts said he believes the executive committee stopped short of that because the violations occurred so long ago and because no school would be awarded state championships in Country Day's place. In such a case, the championship would be vacated.
At Wednesday's meeting, Country Day headmaster Gerald Hansen accused Roberts of not acting honorably and attempting to coerce the school to forfeit the games and championships.
Martin's involvement was uncovered after five Michigan players and a recruit were involved in rollover accident in 1996. NCAA officials questioned how a college athlete could afford a new sport utility vehicle. Eventually, the investigation led to Martin, a retired electrician who ran an illegal lottery in Detroit-area auto plants.
Michigan imposed sanctions on itself because of the scandal, including a one-year postseason ban, and forfeited 112 regular-season and tournament victories from five seasons, plus its victory in the 1992 NCAA semifinal.
In May, the NCAA infractions committee announced that it would ban Michigan from another year of postseason play. But the Wolverines later won an appeal of the NCAA ban, making them eligible for postseason play in 2004.


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Scores of jobs are set to go at the ABC as management of the public broadcaster juggles funding cuts and future output.
Chief executive Mark Scott says the federal government's decision to stop backing ABC International which runs the Australia Network and the Asia Pacific News Centre, led news bosses to call in staff on Monday and flag changes.
"Difficult decisions need to be made," he said on Monday, adding that reduced staff numbers were inevitable.
The international service will take on a new "converged" guise, which could include repackaged content.
The Community and Public Sector Union says up to 80 jobs, mostly Melbourne-based, will be axed.
Voluntary redundancies will not be offered and managers will handpick which staff keep their positions, union president Michael Tull said.
"We don't accept the process of forced redundancies and we believe the ABC is in breach of its industrial obligations," he told AAP.
Mr Tull said there could be more job losses which is bad news for staff and for Australians who expect quality content from the ABC.
The national broadcaster's budget was cut by $43 million in the May budget and an efficiency review has recommended cutting a further $40-50 million.


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I've been talking a lot about laminated veneer lumber (LVL), the raw material we used to build our latest workbench. But what I haven't talked much about is why we chose this material and the characteristics of the workbench design itself.
The as-yet-unnamed bench is just about finished, and I am organizing my thoughts to write the article about the bench for the November 2009 issue of Popular Woodworking.
In some ways, the story here is about two benches.
We chose to build a workbench out of LVL, which sometimes is called Microlam, for several reasons:
1. It is inexpensive, heavy, stiff, stable and widely available in almost every corner of North America. And if you are willing to put in a special order, you can get it in 4″ thicknesses. This would reduce or even eliminate a lot of gluing.
2. I had a lot of questions about it. How hard would it be on the tooling? Would we have to use carbide exclusively? How would hand tools react to the stuff? How easy is the stuff to saw, bore, chisel and rout? Does it warp like solid wood?
3. I get asked all the time about using manufactured materials for making workbenches. I've made a few using Baltic birch that came out nicely. I'm not a big fan of MDF and OSB and the way they sag. Commercial cabinet ply is, to be delicate, kinda crappy these days (see my entries on the joys of Chinese-made plywood for more). After eliminating these products, my gut said that LVL might be my best bet for a workbench made from engineered lumber.
About the Bones
So once I got the material selected, the other task was to design the base, the workbench top and the workholding. The base design is something I've wanted to build for a long time: A workbench that can be built using only one tooling setup on the table saw and a bunch of hex-head bolts.
In all truth, I cut all the joints and assembled the base in less than a day , it was probably six hours , and we stopped to take photos and get coffee. The base is incredibly sturdy and can be assembled in about 10 minutes with a 3/4″ ratchet and box wrench. We painted the base with milk paint to cover up some of the wacky lamination lines we ended up with.
The inspiration for the top came from our local noodle bar, which has tables made using LVL. The stuff looks amazing, even to my eyes, which usually prefer a more traditional look. And the stuff is stiff. We ended up with a top that was 2-1/2″ thick. Once it was assembled and bolted down I had Managing Editor Megan Fitzpatrick stand on top of it and jump on the middle. There was almost no flex. It's gonna be great for handwork.
Plus, we're really curious about how much the stuff will move in service. My research suggests it's going to end up being pretty stable thanks to the vast quantities of glue between each little lamination.
When designing the workholding I wanted it to be a little flashy. I've been building a lot of stuff with a lot of straight lines this year and I wanted to break out the curves. So the sliding deadwoman, leg vise, parallel guide and end vise chop all have classic ogee shapes.
And the workholding had to pass my "kitchen test." It does.
This certainly won't be the last bench I'll ever build. I have a list of four or five more types than need to be built to accommodate other kinds of woodworkers (e.g. apartment woodworkers). But this bench is a design that I think a lot of woodworkers will find useful.
– Christopher Schwarz


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AN EX-SERVICEMAN who attacked his pregnant wife of three weeks walked free from court - so he can get the help a judge said he needed.
Burnley Magistrates Court had heard how Andrew William Monks, 30, had kicked Samantha Monks in the head and thrown a pair of steel toe-capped boots at her in the outburst at their home, on January 27.
The hearing was told how Mrs Monks was injured at the hands of her new husband, but the pair both wanted to reconcile.
The defendant was sent on a course addressing domestic violence issues and told the court he had also turned to the veterans' organisation Salute for help.
Monks, of Barleyfield Mews, Burnley, admitted assault by beating, damage and obstructing a police officer. He was given a two year community order, with supervision and the Building Better Relationships programme and was told to pay a £60 victim surcharge.
District Judge Nicholas Sanders, who said Monks's behaviour had been extremely unpleasant and unacceptable, told the court:" He needs help." The district judge said he was pleased that the defendant was engaging with Salute. He told him :" I think they have the particular insight which you need." District Judge Sanders added:" But make sure you give this your all."
Andrew Robinson, prosecuting, said at the time the defendant and victim had only been married three weeks and she was nine weeks pregnant.
There had been some issues with his drinking in the past. Monks had returned home in the afternoon quite drunk, words had been exchanged and at about 7pm when the defendant said he was returning to associates in Blackburn, his wife had told him :" Well, you go then."
Mr Robinson said Monks had gone towards the victim and kicked her in the head, causing injury. He then threw his work boots, hitting her head. One boot hit the fire, dislodging coal and damaging the carpet.
Sara Lyle, for Monks, said to his credit he said he had wanted to plead guilty at the outset. She added:" I know that both parties want to be reconciled."
District Judge Sanders, who had read a letter from Mrs Monks, who was in the public gallery, said many people charged with similar offences pleaded not guilty on the basis nobody would turn up to give evidence, but the defendant had done the right thing.
He told him :" You clearly have some very good points and you clearly have a problem which you need to address."


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Get more bang for your bottle cap with Fallout: New Vegas Ultimate Edition — available now available in North America on PlayStation 3, Xbox 360, and PC.
Ultimate Edition presents the definitive edition of Fallout: New Vegas — featuring the main game and all six pieces of game add-on content: Dead Money, Honest Hearts, Old World Blues, Lonesome Road, Courier's Stash, and Gun Runners' Arsenal.
New Vegas Ultimate Edition will be available in Germany, Australia, and Nordic territories this coming Friday (February 10th), and will be released in the UK, Italy, Belgium, Luxembourg, and The Netherlands on February 24th.
And to further celebrates the game's release, by popular demand, we're releasing the sheet music for "Begin Again" — the Dead Money song from Just Bell, Mikey Dowling, and Chris Avellone.


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st Bay Regional Parks Department. They removed the fiberglass ins under a mobile home and shot our coating on the entire undercarriage and metal heat ducting. 83% reduction in heater run time for results. http://www.ct-coating.com My phone number and other contact info is there.
Hal Skinner
Hi Don,
Welcome to Home Energy Pros! Feel free to join the conversation in the Forum and Groups. And share your energy efficiency photos, videos and upcoming events. If you're blogging about home performance, this is the place for you!
Don't forget to upload your profile photo. And add your location on our Member Map!
Diane, HEP Moderator
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Created in 2007 as an action sportswear brand by founder Todd Kellogg, Lira has since transformed into so much more than clothes for boys and their boards. Based out of LA, Lira keeps their fingers on the pulse of fashion with innovation and creativity always in mind. With stylish prints, outerwear that goes beyond practical, and accessories that stand out from the crowd, Lira is ready to be a part of your life. Why let the boys have all the fun? Whether you're skating around town or out for a night on the town, Lira is there for you.
No products match your selections. Try clearing your filters.


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As new product launches go, Rubbermaid's Clean & Dry plunger was overshadowed this week by the unveiling of the iPhone 5, depite the innovation it brings to the bathroom cleaning category.
In addition to the Clean & Dry plunger whose key attributes are evident in the name, Rubbermaid also launched the Rubbermaid Bathroom Scrubbers line of cleaning tools. Both products are designed to make bathroom cleaning easier, quicker and more hygienic.
"Our research tells us again and again that when consumers use Rubbermaid solutions in their homes, they feel free to live their lives and focus on what really matters," said Steve Pawl, Rubbermaid's VP of marketing. "This insight naturally extends to the bathroom, where consumers are constantly seeking simpler and more effective solutions. Our line of new Rubbermaid Bathroom Scrubbers and the Clean & Dry Plunger join the Reveal Microfiber Spray Mop to extend the ways Rubbermaid is helping consumers achieve a clean and organized home quickly and effectively."
According to the company, 70% of consumers clean their bathroom at least once per week, despite an aversion to the task. Existing tools like sponges and disposable wipes make it difficult to clean hard-to-reach places. As a result, consumers desire tools that can be customized to their specific frustration, cleaning method and bathroom.
Rubbermaid's new Bathroom Scrubbers provide four tools including the Spray Scrubber, Extendable Scrubber, Flexible Scrub Brush and a 2-in-1 Scrubber. A variety of switchable pads are available – including scour, sponge, bristle and disposable pads – so no matter the mess or surface, cleaning can be tailored to fit the consumers' preferred method of cleaning, according to the company.
As for the plunger, an implement every home needs but no one ever wants to use, Rubbermaid's Clean & Dry product addresses the most objectionable aspects of unclogging a toilet. The product features a NeverWet nanotech coating which forms a shield that repels water much like water beads up and runs off a freshly waxed car. That's a good thing because Rubbermaid's research shows that after just one use, traditional plungers are coated with up to 3.2 million harmful bacteria that reside in toilets. That contaminated water can end up dripping onto floors, cabinets or even an iPhone.


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'Buffalo had 39 minutes in penalties, allowing eight power plays, including five in the second period alone. "We just got into so much penalty trouble,'' defenseman James Patrick said. "We can't be taking four-minute (penalties) and (majors). We killed a double minor and came out of the box, and then took another one. That obviously ruined our momentum, and I think they outplayed us tonight. That's the difference.'''
You are here: Home / SabresBeat / Montreal 3, Buffalo 0


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In Bhikkhu Sona's 'Mystery of the breath Nimitta/The Case of the Missing Simile', there is a passage taken from Vis. VIII, 216.
Visuddhimagga VIII, 216: "In fact this resembles an occasion when a number of bhikkhus are sitting together reciting a suttanta. When a bhikkhu asks, 'What does this sutta appear like to you?', one says, 'It appears to me like a great mountain torrent,' another 'To me it is like a line of forest trees', another 'To me it is like spreading fruit tree giving cool shade'. For the one sutta appears to them differently because of the difference in their perception. Similarly this single meditation subject appears differently because of difference in perception. It is born of perception, its source is perception, it is produced by perception. Therefore it should be understood that when it appears differently it is because of difference in perception (Vis. VIII, 216, p.278)."
Anyone know if Buddhaghosa cooked up this 'occasion' or if it came from the tipitaka?
AIso, I want to know the original purpose of the story of the monks' perceptions of the suttanta.


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CHINO HILLS – The annual Kiwanis Club of Chino Hills will host the Chino Hills Boat Parade tonight.
The parade will begin at 7 p.m. at the corner of Eucalyptus Avenue and Peyton Drive, Chino Hills
Visit chinohills.org for a map of the parade.
Beginning at 5:30 p.m. boats will begin to line up at Eucalyptus Avenue near Community Park. Parade-goers are welcome to look at the boats before the parade starts.
Catch Ayala and Chino Hills High School choir students spread the holiday cheer with traditional Christmas carol tunes.
Between the James S. Thalman library and the Civic Center Chino Valley Unified Key Club students will have snacks.
This year a table will be set up for those interested in filling out sympathy cards for the victims of the shooting in Newtown, Connecticut.
A few hundred sympathy cards have been donated for those will to send a personal message. A banner will also be there too for those willing to write a message.
About 65 boats will be participating in tonight's hour-long parade.
After the parade the public is welcome to look at the boats, that will be docked at the Chino Hills Community Church's parking lot.
Award trophies will be given out to the best boat, best light, most patriotic, best humor/originality and the Mayor's award.


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SENIOR Tories have demanded the Government stop attacking local councils – warning David Cameron if the criticism continues, it could hit the party's re-election campaign.
Thirty-one leading Conservative councillors, including at least two from this region, have signed a private letter urging the Prime Minister to stop "patronising language" being used to attack those who "work extraordinary long hours for our communities".
The leaked four-page letter says: "It is important that you understand how disappointed and even angry local activists are and how many might not be there when we need them as electoral foot soldiers."
North Yorkshire County Council leader John Weighell and Richard Bell, Tory group leader at Labour-run Durham County Council, denied the letter represented a threat to withdraw support.
But Councillor Weighell said top Tory councillors were "concerned about the bad publicity coming to councils from some ministers" and Coun Bell said there was "a lot of concern" about how local government was being treated.
Senior ministers including Communities Secretary Eric Pickles and Conservative chairman Grant Shapps have consistently made outspoken attacks on town hall spending.
In their letter, the councillors say they are concerned over some government policy affecting local government, its accompanying rhetoric and the effect on "our people".
They slam "ill-informed and anecdote-based general criticism and sometimes highly inaccurate personal attacks" and say they are worried about any weakening between the "parliamentary leadership and the party's active local members".
Coun Bell said: "I've been supportive of efforts by the (Durham) county council and Anec (Association of North East Councils) to bring to the Government's attention the particularly high level of cuts that have been coming through to the North-East and Durham. I make no secret of that or apology for that.
"Local government has been getting a tough deal from the Government and local government in the North-East has been getting a very tough deal. I see it as my role to advocate the needs of the people of County Durham to central Government."
He added: "We are supportive of the Government and will be working hard come the next General Election to secure a Conservative government.
"That doesn't mean we're prepared to sit back and take everything without comment or reply, particularly if it's an unfair criticism or policy."
More North Yorkshire County Council News
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