text:
Phase II Study Evaluating ONO-4053 and Cetirizine in Subjects With Seasonal Allergic Rhinitis
This study has been completed.
Ono Pharmaceutical Co. Ltd
Information provided by (Responsible Party):
Ono Pharmaceutical Co. Ltd
ClinicalTrials.gov Identifier:
First received: November 1, 2012
Last updated: April 14, 2014
Last verified: September 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to investigate if ONO-4053 relieves symptoms of allergic rhinitis in seasonal allergic rhinitis subjects exposed to pollen under controlled conditions.
|Seasonal Allergic Rhinitis
|Drug: Cetirizine Drug: High dose ONO-4053 Drug: Low dose ONO-4053 Drug: Placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Randomised, Placebo Controlled, Four Period Crossover Study to Evaluate the Efficacy, Safety of Oral Repeat Doses of ONO-4053 and Cetirizine in Subjects With Seasonal Allergic Rhinitis in the Vienna Challenge Chamber.
Resource links provided by NLM:
MedlinePlus related topics: Hay Fever
Drug Information available for: Cetirizine Cetirizine hydrochlorideU.S. FDA Resources
Further study details as provided by Ono Pharmaceutical Co. Ltd:
Primary Outcome Measures:
- Total Nasal Symptom Score [ Time Frame: 4 months ]To investigate the effect of repeat oral doses of ONO-4053 versus placebo on nasal symptoms elicited by allergen chamber challenge in subjects with seasonal allergic rhinitis.
Secondary Outcome Measures:
- Total Nasal Symptom Score [ Time Frame: 4 months ]To investigate the effect of repeat oral doses of ONO-4053 versus Cetirizine on nasal symptoms (Total Nasal Symptom Score) elicited by allergen chamber challenge in subjects with allergic rhinitis.
- Total Ocular Symptom Score [ Time Frame: 4 months ]Itching and ocular discharge monitored daily
- Pharmacokinetics [ Time Frame: Days 1 and 8 ]AUE (0-2h, 2-6h and 0-6h)
|Study Start Date:
|November 2012
|Primary Completion Date:
|February 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Experimental 1
High dose ONO-4053
Drug: High dose ONO-4053
Other Name: Experimental 1
Active Comparator: Cetirizine
10mg Cetirizine
Drug: Cetirizine
10mg tablets
Experimental: Experimental 2
Low dose ONO-4053
Drug: Low dose ONO-4053
Other Name: Experimental 2
Placebo Comparator: Placebo
Drug: Placebo
None active
Detailed Description:
The purpose of this study is to investigate if ONO-4053 will impact allergic rhinitis symptoms in subjects with seasonal allergic rhinitis when they are exposed to pollen administered at a fixed rate in an inhalation exposure chamber compared to the standard treatment Cetirizine 10mg under the same conditions.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- The subject is aged between 18 and 65 years inclusive, and healthy with the exception of allergic rhinitis or mild asthma that does not require treatment and has provided written informed consent, which signifies an agreement to enter the study and comply with the restrictions and requirements listed in the informed consent form.
- The subject exhibits a moderate to severe response to grass pollen grains in the allergen challenge chamber at Screening.
Exclusion Criteria:
- The subject on examination is found to have nasal structural abnormalities or nasal polyps; a history of frequent nose bleeds, nasal biopsy, nasal trauma or nasal surgery.
- Pregnant or breast-feeding females.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01748344
Please refer to this study by its ClinicalTrials.gov identifier: NCT01748344
|Vienna Clinical Site
|Vienna, Austria
Sponsors and Collaborators
Ono Pharmaceutical Co. Ltd
|Study Director:
|Study Director
|Ono Pharmaceutical Co. Ltd
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Ono Pharmaceutical Co. Ltd
|ClinicalTrials.gov Identifier:
|NCT01748344 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 1, 2012
|Last Updated:
|April 14, 2014
Additional relevant MeSH terms:
Rhinitis, Allergic
Rhinitis, Allergic, Seasonal
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Anti-Allergic Agents
Histamine H1 Antagonists, Non-Sedating
Histamine H1 Antagonists
Histamine Antagonists
Histamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


text:
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text:
Maybe drivers just can't see the "Legacy of Love" monument on the corner of Cedar Springs Road and Oak Lawn Ave. Maybe it needs to be a little bigger. Maybe it's all those flashing lights warning drivers that pedestrians are crossing the street a couple of blocks away.
This morning another motorist crashed into the monument. The vehicle appeared to have ended up between the protective brick pillars and was gone by the time I got back with a camera.
Kudos to AT&T
While I was out I noticed that the new AT&T store next to the Verizon store is almost complete.
Kudos for a building with an interesting design that nicely compliments Eatzi's across the street and for having a sense of humor by placing the store directly next door to Verizon. Now T-Mobile needs to come in there and build something more fabulous with the billions it just got from AT&T when their merger failed.


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Vote for FDRD in Community Reinvestment Project for chance to win $20,000
November 3, 2012
Friends of the Dillon Ranger District was picked out of many charities by Colorado Native Lager to be a part of the Community Reinvestment Project.
The organization has a one-in-four chance of winning $20,000. Voting began Friday and will extend through Nov. 16 at 5 p.m. To vote, visit the Colorado Native Lager Facebook page.
Any funds awarded to FDRD would go toward over 50 different volunteer-powered trail improvement and ecological restoration projects on national forest lands in Summit County.
"Our efforts will improve sustainability on popular recreational trails, help close and restore unsustainable routes, replant trees and stream-side vegetation near our waterways, and engage volunteers ranging from 6 years old to 60 years young in meaningful service projects outdoors," said Kate Vumbaco, administrative assistant for FDRD.


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Note: This item is more than nine years old. Please take the publication date into consideration for any date references.
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News Release
Media Contact: TPWD News, email@example.com, 512-389-8030
May 6, 2008
McKinney Leaves Environmental Legacy at TPWD
AUSTIN, Texas — Dr. Larry McKinney, known affectionately as "Dr. Doom" for his candid, outspoken approach to addressing environmental issues, is leaving the Texas Parks and Wildlife Department a legacy not built on despair, but on hope.
For more than 20 years with the department, McKinney has championed endangered and threatened species and served as a proponent for resource conservation, water resources in particular. McKinney, director of Coastal Fisheries and senior director of Aquatic Resources for TPWD, has been named executive director of the Harte Research Institute for Gulf of Mexico Studies at Texas A&M University-Corpus Christi. He assumes his new role in July.
"All of us at Texas Parks and Wildlife Department will miss Dr. McKinney's extraordinary leadership, scientific acumen, vision, and conservation ethic while serving as Director of Coastal Fisheries," said Carter Smith, TPWD executive director.
"During his nearly 25 year tenure with the agency, he has been at the forefront of innovative conservation efforts to protect our seagrass meadows, to ensure adequate freshwater inflows into our bays and estuaries, to enhance our sport fisheries, and to conserve our unique fish and wildlife resources along the Texas coast," Smith said. "His ability to work effectively and collaboratively with divergent and sometimes competing constituent groups on a wide range of coastal and water related issues has served this department and the state of Texas very well. Larry has been a friend, mentor, and trusted advisor to many of us in the conservation field, and we wish him all the best as he assumes this critically important leadership role at the Harte Institute."
McKinney has been carrying water for fish and wildlife since day one. During his tenure at TPWD, he has been a major force behind research and recommendations to provide freshwater inflows to estuaries and in-stream flows for rivers and reservoirs; wetland conservation and restoration and other issues related to the ecological health of Texas aquatic ecosystems.
"When we started in 1985, environmental review of water permits and consideration for fish and wildlife did not exist," said McKinney, who noted back then only two permits in the entire state included environmental provisions. "Today every water permit includes such consideration and the passage of SB-1, SB-2 and especially SB-3 will put into place the policy framework that if adopted by the legislature will assure water for fish and wildlife on a statewide basis."
As director of the agency's now defunct Resource Protection Division, McKinney advocated working with private landowners to provide conservation for threatened and endangered resources. He was able to influence significant revisions of the federal endangered species act to better work with private lands and through cooperative efforts.
He was also responsible for the development of a civil process and valuation system for fish and wildlife to recover the value of fish and wildlife resources lost to illegal activity (poaching, pollution, etc), which has meant millions of dollars to wildlife and habitat restoration.
As director of the agency's Coastal Fisheries Division, McKinney lead the development of programs to address aquatic vegetation management, invasive species, shrimp aquaculture and disease management, vehicle traffic in riverbeds, paddling trails, and offshore aquaculture. He oversaw the development of the State Wetlands Plan and the Seagrass Conservation Plan and was able to accelerate and will soon bring to conclusion the shrimp license buyback program. This program has been the fundamental conservation tool in maintaining the health and productivity of our recreational fishery.
"Texas is the only state with a significant saltwater angler population that has seen positive increases in numbers over the last 5 years — a 25 percent gain," McKinney noted. "Florida and California saw an 18 percent drop over that time and all other Gulf states declined sharply. Not only that but our anglers are fishing twice as much and the economic benefits to Texas include the creation of over 5,000 jobs during that time. The action we have taken like regional regulations and the continued emphasis on ecosystem management has put our fisheries in their best condition in the last 30 years."
McKinney earned his Ph.D. from Texas A&M University in 1976 and is a recognized authority on the habitats of amphipod crustaceans in the Gulf of Mexico and Caribbean Sea. In 1976, McKinney was a Smithsonian Fellow and from 1977 to 1980 he was a research associate and instructor at Texas A&M University-Galveston. Prior to joining TPWD, McKinney was director of the Texas Environmental Engineering Field Laboratory in Galveston where he worked on water issues including the diversion of the Mississippi River.
The Harte Research Institute for Gulf of Mexico Studies is an endowed and developing research institute that supports and advances the long-term sustainable use and conservation of the Gulf of Mexico through a tri-national approach between the United States, Mexico and Cuba. The Institution was created in 2000 by a $46 million endowment from Edward H. Harte, philanthropist and former publisher of the Corpus Christi Caller-Times.
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Many personal finance experts recommend making a budget. While that is good advice, it's easier said than done. Who has time to classify each expense into categories like "groceries," "utilities" and "mortgage"?
Software and online tools can help with this task, but here is an alternate, low-tech solution: Take your savings off the top, and then spend the rest.
Do this by following these four steps.
Step one: Decide what percentage of your overall gross income that you would like to save for retirement. Many experts recommend saving between 10 percent and 20 percent, depending on your age, existing portfolio balance and expected number of years until retirement.
Arrange with your human resources department to have those retirement savings withdrawn instantly from your paycheck and put into an employer-sponsored retirement account, such as a 401(k) or 403(b).
Step two: Decide what percentage of your take-home pay you would like to save for things other than retirement. This money can be used to build an emergency fund, pay cash for your next car or fund a vacation.
At this stage, you are simply picking a goal. Don't worry -- yet -- about how "realistic" the goal seems, or about how you will achieve it.
Step three: Log into your bank account to find out the total of how much you've spent over the past six months. Divide that number by six. It should give you a reasonable estimate of your current average monthly expenses.
Are those expenses less than your monthly take-home income?
If you answered "yes," calculate how much you are saving, and how it compares to your ideal savings rate.
If you answered "no," you've found a serious red flag. It's time to pare down.
Which expenses can you trim to reach your ideal rate? Can you cancel your cable subscription? Can you reduce the number of times you eat at restaurants each month?
You don't necessarily need to track every penny. Instead, brainstorm ways in which you could trim back your expenses. Add up how much those expenses will save you over the span of a month. Add this to your "savings" category.
Step four: Set up an automatic monthly transfer from your checking account to your savings account. Transfer as much as you can reasonably save.
Paula Pant blogs at AffordAnything.com about creating wealth and living life on your own terms. She's traveled to nearly 30 countries, owns five rental units and works for herself. Follow Paula on Twitter @affordanything


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iHerb Customer Reviews
It Works!
Verified Purchase
It Works!
Thank goodness for mastic gum. After a year of trouble with a stomach ulcer, after just 4 weeks on mastice what an improvement! I feel like I'm well on the way to being healed. Very little pain anymore. I take 4 tablets (2000 mg) on an empty stomach before bed.
Was this review helpful to you?
It Works!
Posted by iHerb Customer on Oct 29, 2008 | Verified Purchase
Thank goodness for mastic gum. After a year of trouble with a stomach ulcer, after just 4 weeks on mastice what an improvement! I feel like I'm well on the way to being healed. Very little pain anymore. I take 4 tablets (2000 mg) on an empty stomach before bed.
Fantastic results for me
Posted by iHerb Customer on Jun 23, 2010 | Verified Purchase
Delivery was fast and efficient. Mastic gum helped my gastrointestinal problem despite doctors saying they could find nothing wrong. Continuous pain in upper right quadrant; underneath rib, upper right back and lower right side (felt like something scraping inside my colon). After a week of taking Mastic Gum the reduction in symptoms was incredible. Slight nausea for the first few days but it subsided. Took 2 first thing in the morning and 2 before bed for one month. Reduced to 2 x am only with return of symptoms.
Excellent product, cured long term, painful gastritis for me in a month. (not this brand initially, but I am using this brand since and it's as effective....exaclty the same stuff)
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Excellent product, excellent effects on gastritis. Had gastritis for over a year, constant burning throbbing pain in my stomach. tried a bunch of drugs, nothing worked. Tried a months course of Mastika (different brand before) and it cured the gastritis pain by the end of the monthly course. This was a daily, strong, throbbing pain that occurred after eating. This was unlikely therefore a placebo effect; it stopped a severe pain that had been occurring daily for over a year. Now I take a maintenance dose every night. This stuff saved me from the awful scourge of gastritis. I will love it forever. If you have gastritis, TAKE IT! make sure your stomach is empty before you take it. Better effects that way. Good luck.
Mastic Gum for Gerd - acid burned stomach -duodenal hernia
Posted by iHerb Customer on Sep 23, 2010 | Verified Purchase
I have been taking 2 caps on an empty stomach before breakfast for the past three days and already I feel better. My gastroenterologist prescribed Nexium, but I wanted to try this before taking a prescription medicine that might cause more unpleasant digestive side effects. For months I would wake up during the night with knawing, burning pains. After taking this for just three days I have been sleeping through the night.
No doubt
Posted by iHerb Customer on Jul 28, 2010 | Verified Purchase
There is no doubt that this stuff has helped my h.pylori symptoms. I have yet to have a test done to see if it is eradicated, but it's the first time in 5 years that I have been able to eat a normally.
Mastic gum
Posted by iHerb Customer on Sep 08, 2010 | Verified Purchase
This is very good for aiding digestion and repairing cavities (when combined with bone building supplements).
Good product to fight H Pylori
Posted by iHerb Customer on Aug 01, 2011 | Verified Purchase
We've been taking this product for 2 weeks now, after having peptic ulcers and a H pylori infection for the last few months. We now feel heaps better. Mastic gum combined with Good Certified Manuka Honey seems to be the way to go. I highly recommend this instead of antibiotics which risk making your infection even more resistant. Also having them 2pills 3 times a day half an hour before meals is more effective.
Effective in helping with bloatedness
Posted by iHerb Customer on Jan 17, 2015 | Verified Purchase
I had stomach troubles for the past 2 years. It all began with a H-Pylori infection, which was solved by triple-therapy. However, the symptoms of gastric pain, bloatedness and fatigue kept returning over the past 2 years. The last time I had a doctor's checkup, I was clear of any H-Pylori infections. However, I still experienced some of the symptoms above. I have been taking 4-6 capsules of mastic gum daily and find it to be extremely effective, especially with bloatedness. My recommendation is to take the supplement on an empty stomach, an hour before meals. Good luck
Success with Mastic Gum
Posted by iHerb Customer on Sep 02, 2010 | Verified Purchase
Great product, started this about 6 weeks ago and have noticed alot of improvement in gastritis and GERD symptoms, am able to eat some meat once again after not being able to eat meat without pain. Getting better every day.
great mastic
Posted by iHerb Customer on May 25, 2009 | Verified Purchase
been taking this for awhile to fight h. pylori, seems like a good product. really effective when teamed up with other known h. pylori killers.


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New Progress: LRI Research Yields Breakthroughs
In Founding the LRI, the S.L.E. Lupus Foundation Ushered In the Golden Age of Lupus Research
The S.L.E. Lupus Foundation helped build New York into the world's largest hub of lupus research, attracting new talent to the field and fostering innovation and discovery. The Foundation founded the LRI to expand that support to the nation, funding only the most novel research projects. And in just one decade, the LRI delivered outstanding research advances with many of the most pivotal discoveries in lupus of the century. Progress is happening at an unprecedented rate.
The Numbers Speak Louder Than Words!
- Over $170 million for novel, innovative research in lupus
- 150 Novel Research Grants awarded
- 84% success rate: Investigators prove novel hypotheses, publish results and win extended funding to move ideas from bench to bedside
- 92 cents of every dollar goes directly to fund novel lupus research
Novel Research Delivers Discoveries That Matter
Lupus Awareness Month celebrates documented, solid scientific success that impact patient lives. Share our excitement in the results funding only the most novel innovative research has produced:
Predicting flare.
Two new lab tests to predict lupus flare. By detecting the earliest signs of an upsurge in disease activity the tests are designed to improve disease management and accelerate the testing of new drugs in clinical trials. Researchers: Mary K. Crow, MD and Emily Baechler Gillespie, PhD
Predicting heart risk.
For the first time clinical research showed that a blood test for homocysteine identifies lupus patients most at risk for cardiovascular disease. Doctors are now using the test to guide preventative treatment and reduce the chance of life-threatening cardiac events. Researcher: Joan Von Feldt, MD
Discovering how lupus attacks the brain.
Researchers uncovered how the lupus immune system attacks the central nervous system (CNS), This insight has led to work on a new targeted treatment for neurological and psychological complications of lupus. Researcher: Betty Diamond, MD
Discovering how lupus harms the heart.
A chemically altered form of 'good' cholesterol was found to contribute to circulatory system damage in lupus. This discovery has led to new ways to identify and treat patients at risk of heart disease. Researcher: Bevra Hahn, MD
Transforming kidney diagnosis.
Researchers devised new non-invasive tests to diagnose and guide treatment of lupus kidney disease as alternatives to surgical kidney biopsies. Researchers: Chandra Mohan, MD, PhD; Chaim Putterman, MD; Joshua Thurman, MD
Discovering new genes.
Genetic breakthroughs uncovered new culprits in lupus — the Toll-like receptors. Drugs that inhibit these proteins are soon to be tested in lupus patients. Researchers: Silvia Bolland, PhD and Ian R. Rifkin, MD, PhD
Smarter drug delivery.
Targeting drug doses directly to disease causing cells using innovative nanotechnology promises to make existing lupus treatments safer and more effective. Researcher: Tarek Fahmy, PhD
Together let's ramp up the pace further as we are closing in
on the cause and going for the cure!


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See Also:
Tuesday, September 5, 2017
Where To Smoke: La Casa del Habano, Prague, Czech Republic
Wednesday, August 16, 2017
Where To Smoke: Kruger's American Bar, Vienna, Austria
Tuesday, August 8, 2017
Where To Smoke: La Bodeguita Del Medio, Budapest, Hungary
Wednesday, July 26, 2017
Where To Smoke: Shelly's Back Room, Washington, D.C.
Friday, July 21, 2017
Where To Smoke: The Times Bar, Berlin, Germany
- More from Where to Smoke
Don Sebastião Restaurant, Portugal
Bill Nestor
Posted: June 29, 2009
A recent peregrination brought me to the harbor of Lagos in the Algarve region of southern Portugal. Seabird calls—sharp cackling Herring Gulls, piercing shrills of Common Terns and the deep cacophony of Great Black-Back Gulls—mingled with seaside scents and vistas along the shoreline. Sensory stimulus is the first impression of this historic coastal town of 18,000.
The shore setting is an essential ingredient of the towns past and present as a source of food and point of embarkation. Vasco da Gama sailed from the port in 1499 on his epic voyage of discovery. An armada of 800 vessels led by Dom Sebastião, the newly crowned 18-year-old King of Portugal, embarked from Lagos in 1578 on an ill-fated crusade to conquer a North African city.
A statue of the Don Sebastião Restaurant's namesake stands in the main square in front of the Town Hall. From its beginning in 1979, the restaurant has gathered a following of diners and a reputation for delicious traditional fresh food and local ambience with warm, friendly service. It is locally renowned for quality cuisine from a menu inspired by Portuguese fare and the sea.
The restaurant is located on a cobblestone walking-only street that is a short distance from the waterfront. Each day, boats bring in fresh catches of fish, shrimp, crabs, oysters and other seafood. The interior showcases Portuguese gothic décor and pottery on whitewashed walls in the cobbled floor main dining area. This all quickly fades to backdrop as food and wine take center stage.
Starters of chouriço, flaming pork sausage grilled over local firewater, are served as wines are poured. The red of choice, Esporão Reserva 2007 Alentejo, and the white of the night, Quinta do Carmo 2007 Alentejo, continually flow throughout the evening. The red is hearty but not overly full-bodied while the white is clean and refreshing; each is simple, elegant palate pleaser that goes down too easily.
The delectable cuisines from proprietor Antonio Gomes, chef Paulo, waiter Victor and crew mix complimentary essences that seem to explode in the brain as well as on the tongue. The hot spices blend with the textures of vegetables, seafood and pasta in extraordinary balance, cooked to perfection. Sweet, fresh raw oysters from nearby Alvor River and a Don Sebastiao salad followed. The signature salad of lettuce, tomato, cucumber, white beans, cooked beetroot with a zesty vinaigrette dressing was crisp and tasty.
My entrée of charcoal-grilled jumbo tiger prawns with Piri-Piri, a sauce of small hot peppers, triggered a dramatic taste response. Also sampled was an equally delicious melt-in-the-mouth charcoal-grilled sea bass seasoned with a butter and olive oil sauce. Both came from the nearby Atlantic Ocean, the prawns from near Africa and the sea bass farther north.
Don Sebastião's house specials are fresh seafood and fish, grilled or boiled, and lamb stew in red wine. Meat dishes and several veggie options are also available. All are made to order in-house and served with a variety of bread and rolls from a local bakery.
Large aquariums showcase the variety of colorful live crustaceans: lobsters, crabs, crayfish, clams and oysters. Main courses include pork chops with figs, succulent shellfish, rice, and shrimp cooked with savory spices.
There are two large dining rooms decorated in a rustic style with alfresco dining also available on the cobbled front patio or the roof terrace. The underground wine cellar is especially engaging, showcasing a broad collection of Portuguese wines, vintage Port (dating back to the 1700's), Madeira and impressive historic bottles from the owner's private collection.
A visit to the cellar after dinner for port with queijo da serra, a cured, creamy sheep milk Serrinha Cheese from Portugal's Serra da Estrela mountains continued the parade of taste sensations. The cellar houses 14,000 bottles and 240 varieties of white, rose, and red. Tucked in the corner was a humidor with an assortment of brands. We selected Hoyo de Monterrey Epicure No. 2s from a cabinet and headed to the patio.
The dessert selection included morgados cookies made with local almonds, figs and eggs and almond cakes. I took great pleasure in these sweets with after dinner coffee, port and a strong local alcoholic spirit, the aguardente de medronho, distilled from butus berry fruit while enjoying slow burning Cubans on the patio adjacent to the street where people passed by arm in arm on evening strolls.
Lagos and the Algarve are heavily influenced by tourism but still retain many qualities of the country and people. There is an authentic taste of Portuguese culture and cuisine at resorts and quaint beach towns in hidden coves from Praia da Luz to Sagres and the mountain village of Monchique, each rich in lifestyle with warm and welcoming people.
Although the Algarve is one of best golf destinations in the world, with 36 courses in a 74 mile stretch, the region offers plenty for non-golfers as well, including miles of golden-sand beaches and beautiful walking nature trails, charming villages, seaside national parks, historic architecture, sailing, fishing and other water sports.
Algarve's proximity to and influence of the sea pervades much of life—climate, weather, agricultural, cuisine and customs. The sharing of food and wine is central to the culture. Restaurants are gathering places where people celebrate traditional local fare and the enjoyment of dining together, a ritual that's magnified exponentially by this geographic phenomenon that's repeated each and every night.
Don Sebastiao Restaurante
Rua 25 Abril 20/2 8600-763 Lagos, Portugal
Phone: 351-282-780-480
Email: firstname.lastname@example.com
Bill Nestor writes about travel, golf and lifestyle from his home in Vermont.
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Topic: Back to Work
Hi all, I know it's a small milestone but I am getting to the point where I will celebrate any of them. Mark went back to work today....the first day he has worked since the middle of May. Not sure how long he will make it but he's there. Round #3 of chemo was Friday and all labs looked good....bili was great and liver function almost normal. Only bad was his white count was up but he's still on antibiotics from the last round. No fevers this time and we may get to skip the normal week long hospital stay after chemo (I hope so). His boss thankfully understands how tired and weak he still is so they have him working in the office rather than production. Not sure he will like that.
Also our son with thyroid cancer had his full-body scan last week and NO residual cancer. He got a very small dose of radioactive iodine and then a scan this week. We take him to college on Saturday and he won't have to follow up until Christmas Break.


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A teacher, a coach, board member and friend, G. Frank Etheridge's tenure has come to an end. He will be retiring at the end of his term with the Nov. 2 election,
The public schools of Williston will host a reception in his honor from 4 p.m. to 6 p.m. in the Williston Middle School Cafetorium.
The public is invited to share fond memories, much laughter, punch and cake. Please RSVP to 352-528-2941 by Oct. 27.
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A Walk in ManhattanLogic puzzles require you to think. You will have to be logical in your reasoning.
It happened in midtown Manhattan during the July 4th celebration; Sam walked several kilometres from West 32nd Street all the way to West 63rd Street without seeing anyone or being seen by anyone. It was a clear sunny day and he could see where he was going. He did not use any disguise or unusual method of transportation. Even though Manhattan was swarming with people not one person saw him. How could this be possible?
AnswerHe was walking through the city sewer system.
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Zimmermann limits Reds to one hit in shutout
Washington holds Cincinnati to lone knock for second straight game
WASHINGTON -- Is Jordan Zimmermann the best pitcher in the Nationals' rotation? As of right now, the answer is yes. Zimmermann pitched his second complete game of the season, and first career shutout, as the Nationals blanked the Reds, 1-0, at Nationals Park on Friday night.
The Nationals have won two straight games and find themselves a game over .500 with a 12-11 mark.
Zimmermann needed just 91 pitches to complete the game. He allowed one hit, Xavier Paul's leadoff single in the third, struck out four batters and had 12 ground-ball outs. He started the game by retiring 12 of the first 13 hitters he faced. The Reds didn't have a runner in scoring position in the game.
Davey Johnson called it the best-pitched game he has seen since he became the manager of the Nationals in 2011.
"Low pitch count, he really went after them," Johnson said. "I never really had any qualms about letting him hit [in the eighth inning]. Even if there was a runner on third and nobody out, I was going to let him hit. … He was throwing the ball good. He earned every right to go all the way. It was fun to see."
Zimmermann has been in the Major Leagues for five years, and he has never pitched 200 innings in a season. Having Tommy John surgery in 2009 is one reason he never reached that goal. Once he came back from the procedure, Zimmermann was on an innings limit until 2012.
"It's just experience. He knows how [the opponents] react to his stuff. He has always been pretty aggressive," Johnson said. "He made good pitches all night. He was pitching out front all night. When you get a club like that, they are going to swing and put balls in play, but they are not going to center on many."
Zimmermann said his goal to reach 200 innings this season, and the way he is going, it won't be hard to reach. He said he is getting deeper into games because he is throwing strikes and trying to not get deep in the count. Zimmermann is trying to put the ball in play, and strikeouts are not a priority this year.
"I don't care about strikeouts. I don't want to walk anyone, so that's what I'm trying to do," Zimmermann said.
Zimmermann said Friday's outing was the best he's felt in a long time.
"I had a really good slider tonight, and a good fastball to go with it," Zimmermann said. "We knew [the Reds] swung early, and we wanted to throw first-pitch strikes and quality pitches, let them get themselves out, and let the defense work. That's what we did tonight."
It marked the second day in a row that a Nationals starter allowed one hit in a game. On Thursday, Gio Gonzalez pitched a one-hitter for eight innings before Rafael Soriano finished the win with a hitless ninth. According to the Elias Sports Bureau, the last D.C.-based team to allow one hit or fewer in two straight games was on Aug. 10-11, 1917, when the Senators faced the White Sox in Washington.
"If my guys attack hitters like they have the last two days, it's going to be a problem. I don't care if it's a good-hitting team or a bad-hitting team," Johnson said. "You don't get a lot of pitches to look at. You are hitting behind all the time. … Low pitch count, you are feeling strong all the way through the game."
Said Reds manager Dusty Baker: "We just didn't find any holes. We've just got to keep swinging. He was good tonight, but we didn't find any holes. We've just got to keep swinging until we find some holes."
Reds right-hander Homer Bailey was almost as good as Zimmermann. Bailey pitched seven innings, allowed just one run on five hits and struck out six batters. The one run scored in the fourth inning. Bryce Harper tripled into the right-field corner with one out and scored on a single by Jayson Werth with the infield in.
"Homer is pretty good. He has a good split-finger. He uses it often," said Harper. "He pitched up in the zone with that fastball. It's a pretty tough pitch. I got pretty good wood on it [on the triple] and I took advantage of it."
In the sixth inning, with a runner on third, Harper hit a ground ball to Bailey, who was able to throw Denard Span out at the plate for the second out of the frame.
"Homer threw excellent," Baker said. "It was a good ballgame, we just came up on the short end of the stick. Things go in streaks, and sometimes there's no explaining why. We went through this last year. Now, we're in that 'Can't buy a run' phase."
But it was Zimmermann who stole the show, winning his team-leading fourth game of the season.
"He pitches his butt off every time he goes out there," Harper said. "He is a competitor, he uses his fastball really well and he throws a lot of strikes. You are going to get a great performance out of him every night."
Bill Ladson is a reporter for MLB.com and writes an MLBlog, All Nats All the time. He also could be found on Twitter @WashingNats. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Hello Belisma Bye Kitty Women T-Shirt
Product Color:
Product information
The Women T-Shirt Hello Belisma Bye Kitty is our old-school favorite. Perfect for use in sports where you are bound to sweat and need wide range of movement. Short sleeves to let cool air in on those hot and sunny days. Also great for every day use and to show everyone your love for Hello Belisma Bye Kitty.
This product is made of the finest combed jersey which feels soothing against your skin. Shoulder-to-shoulder taping guarantees long life and a good fit. Belisma Women T-Shirt is available in 17 different color options. Heather Grey: 80% Cotton/20% Polyester. Remaining Colors: 100% Cotton.
Sku: TC2ST0000008781818180449WHINRE000


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A DRINK-DRIVER caught on a petrol station was on his way to get more alcohol, Burnley magistrates heard.
Butcher Eugenijus Valancius, 51, was spotted reversing into another vehicle by police at 11.20pm.
A test showed he had 96 micrograms of alcohol in 100 millilitres of blood — the legal limit is 80.
Valancius, of Larch Street, Nelson, works at Woodhead Bros at Colne. He admitted driving with excess alcohol on the Shell Petrol Station, Manchester Road, Nelson, on January 11.
Valancius was fined £250, with £85 costs and a £25 victim surcharge and was banned for 14 months.
Graeme Tindall, for the defendant, said he had had two cans of beer with friends and was driving to the off-licence to get more.
He didn't particularly feel any ill-effects of the alcohol and thought he would be OK, being of large build.


text:
Copyright © 2001-2017 | Mott
Media, L.L.C. | All Rights Reserved
We carry many of the major Christian home school publishers, including Alpha Omega Curriculum, Apologia Curriculum, Janice VanCleave Science, Bob Jones Curriculum, Beautiful Feet, Christian Liberty Press, Switched-On Schoolhouse, History Alive, Mystery of History, Mott Media, and Progeny Press - just to name a few.
When you click on the subtopic, all the products that fit that topic are listed in alphabetical order, including a picture so you can see what you will get, product number, grade level, and price. By clicking on the picture or title, you can get a full description of the product. These descriptions tell you what is covered in the material, the number of pages, and how to use the product. We try to make these descriptions as practical as possible - we dont just rely on sales copy. In many cases, we offer additional tips from homeschoolers who have used the materials.
By clicking on the Series Notes, you can get information about the publishers program and how the series is designed. Loris Notes offer specific tips on how to use the product.
One unique feature of our product descriptions is the Profile Notes. Every product is categorized by learning styles to help you match the curriculum to your childs own learning style. By clicking on the Learning Styles Helps button, you can find definitions and all sorts of information to help you select the best material. You can also use the Learning Profile Search under the Search Button to look for curriculum that matches your childs learning profile: visual, auditory, hands-on, thinking style, personality type, and natural talents or intelligences.
Our Advanced Search lets you find products by age, grade, publisher, author, title, subject, price all sorts of search criteria. All Christian publishers are marked with a cross by the name so you can easily identify the Christian homeschooling curriculum. When you search, you wont be bombarded with anything and everything that remotely matches your search. We have a highly sophisticated search tool that limits the results to only those criteria you selected. The list comes up in alphabetical order by Title not by the most expensive items first so you can easily find what you are looking for.
Homeschooling is legal in every state, but each state sets its own requirements and regulations, so we have provided a link to the major home school support groups in each state under the Legal Questions Button. The support group sites offer contact information for families doing homeschool in your area, as well as information about the legal requirements specific to your state. Once you know these guidelines, you can select the curriculum that meets your states regulations.


text:
Protects the area under your t-top
Lightweight, weather-resistant 6-oz. polyester
Full-length zipper for easy access
Installs without removing outriggers or antennas
A Covermate T-Top Cover is a quick and simple solution to protecting the essential area of your boat, under the T-Top. This lightweight cover is made of weather-resistant 6-oz. polyester. Easy to install, this cover is designed to protect the forward livewell/seating area and the leaning post/captain's chair at the helm. Features a full-length zipper entry, Velcro closure sleeve that allows antennas and outriggers to pass through, and an adjustable sewn-in elastic draw cord. Mesh storage bag included. Five-year warranty. Not recommended for trailering.


text:
"Please, what task, Sir?" said Jill.
"The task for which I called you and him here out of your own world."
This puzzled Jill very much. "It's mistaking me for someone else," she thought. She didn't dare to tell the Lion this, though she felt things would get into a dreadful muddle unless she did.
"Speak your thought, Human Child," said the Lion.
"I was wondering—I mean—could there be some mistake? Because nobody called me and Scrubb, you know. It was we who asked to come here. Scrubb said we were to call to—to Somebody—it was a name I wouldn't know—and perhaps the Somebody would let us in. And we did, and then we found the door open."
"You would not have called to me unless I had been calling to you," said the Lion.
"Then you are Somebody, Sir?" said Jill.
"I am."
From The Silver Chair
Compiled in A Year with Aslan
The Silver Chair. Copyright © 1953 by C. S. Lewis Pte., Ltd. Copyright renewed © 1981 by C. S. Lewis Pte. Ltd. All rights reserved. Used with permission of HarperCollins Publishers. A Year With Aslan: Daily Reflections from The Chronicles of Narnia. Copyright © 2010 by C. S. Lewis Pte. Ltd. Extracts taken from The Chronicles of Narnia. Copyright © C. S. Lewis Pte. Ltd. 1950-1956. All rights reserved. Used with permission of HarperCollins Publishers.


text: Western chambray shirt Item E7338 Color: INDIGO Size: All sizes are US sizes. 000 8 Size Charts Quantity: 1 2 3 4 5 6 7 8 9 Prices do not include taxes. Add to Bag Wishlist Add to Bag Add To Wishlist share: size & fit Body length: 27 1/2". Product Details Our polished version of a classic Western shirt in a softer-than-soft chambray with shell buttons. For more ways to wear it, watch our Style Hacks video now. Cotton/Tencel® lyocell. Long roll-up sleeves. Chest pockets. Machine wash. Import. Item E7338.


text:
HPS709 - Clinical Placement and Case Analysis 2
Unit details
|2018 unit information
|Enrolment modes:
|Trimester 1: Burwood (Melbourne), Waterfront (Geelong)
|Credit point(s):
|Unit chair:
Amanda Dudley and Melissa O'Shea
HPS706 and HPS777
|Incompatible with:
|Contact hours:
55 days of supervised clinical placement (approximately two days per week), weekly online activities as part of the CPH online component of the unit (see Module 2) and a case analysis/case conference seminar (one day).
The aim of this unit is to provide students with the opportunity to establish their clinical psychology skills. Students are be expected to demonstrate key competencies in ethical and professional frameworks as well as psychological assessment and intervention skills.
Placements provide students with opportunities to develop clinical psychology skills in a range of settings such as adult, adolescent, acute, chronic, inpatient, community, forensic and/or rehabilitation services. It is expected that students will undertake either an adult OR a child/adolescent placements that will complement their other placement units.
The placement program will be established jointly by the student, the placement coordinator, and the practitioner(s) supervising the placement. This will include the minimum amount of face-to-face contact time with clients and the minimum supervision requirements. Placement Learning Contracts will specify learning objectives and key competencies as well as the responsibilities of the student, the Agency Supervisor and the Placement coordinator. Students will be required to have client contact and carry their own caseload, under supervision. The student's performance will be reviewed at a mid and end of placement meeting. All meetings and paperwork are to be completed and are considered part of the unit requirements.
This unit also consists of a Collaborative Practice in Healthcare (CPH) Online Unit. This involves self-directed IPE topics where students explore key themes relating to collaboration, health professionals roles, leadership, conflict management, and team development. There is also a case conference stream where students apply the knowledge and skills acquired through the self-directed IPE stream and work as an inter-professional team. Weekly discussions with their team via CloudDeakin and developing care plans for interesting cases is required.
The unit also involves a Case Analysis seminar, which is attended by all second year clinical masters students, and facilitated by staff. Students will be required to present a case from their placement experience. The seminar will provide the opportunity for students to give and receive feedback from staff and other students.
Assessment task 1: Attendance at placement for a minimum of 55 days
Assessment task 2: Presentation of logbook to the University Supervisor at the final placement review meeting (completion of the placement)
Assessment task 3: Satisfactory report on professional and ethical competence of the student from the Placement Supervisor and University Supervisor at the final placement review meeting (completion of the placement)
Assessment task 4: Satisfactory case report of approximately 3000 words written by the student and submitted to the University Supervisor within 21 days of completion of placement
Assessment task 5: Attendance at, and active participation in, the Case Analysis seminar and satisfactory presentation of a case
Assessment task 6: Satisfactory completion of the CPH online unit
These assessment and procedural components constitute 100% of the assessment for this unit and failure to satisfactorily complete the requirements of any one component will result in the student failing the unit, preclude the admission of the student to the next placement and may result in the student's exclusion from the course.
Unit Fee Information
Click on the fee link below which describes you:


text:
Academy for Jewish Religion - California Is Regionally Accredited
Regional accreditation is a good thing. Attending a regionally accredited institution is important if you may want to transfer credits to another institution or if you want to attend a post-graduate program.
|Regional Accreditations for Academy for Jewish Religion - California
|Western Association of Schools and Colleges


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As Hendersonville resident Ellie Thrush arrives for her yogalates class at Brightwater Yoga on Main Street Friday, the fit and trim 81-year-old is all smiles.
As Hendersonville resident Ellie Thrush arrives for her yogalates class at Brightwater Yoga on Main Street Friday, the fit and trim 81-year-old is all smiles.
"When I do yogalates, I feel relaxed and happy," she said. "I feel centered and pleased that I know I'm working for the betterment of positions."
Yogalates — a combination of yoga and Pilates — helps Thrush keep her energy up for her daily hiking routine.
"It's about balance and flexibility," she said.
Brightwater Yoga owner Pam Foushee started offering weekly yogalates classes in early January and Friday's class had about a dozen participants, ranging in age from what appeared to be mid-40s to Thrush in her '80s.
Foushee has studied yoga for about five years and was a yoga student at Brightwater before becoming its owner.
"I fell in love with the space and the original owner, Leigh Ann Mertens, so I purchased the business in May," she explained.
Since then, she has introduced laughter yoga and yogalates, and in February she'll hold a partners yoga class for couples. On the first Friday in February, she's offering a free yogalates class for those who want to try it. Brightwater also offers massage services.
The yogalates instructor is Lynn Edgar, a certified yoga therapist at the 500-hour level who has been teaching yogalates for 12 years. She teaches in several places around Hendersonville and also offers private lessons.
"Yoga is an Eastern tradition that joins mind and body," she explained. "Pilates is a method of physical and mental conditioning. Pilates was a German man who was born a sickly kid and he worked on his own health." Once he discovered what helped his body improve, "he wanted to share the method of Pilates. He brought it to this country in the 1920s."
Edgar said she loves both yoga and Pilates, so she enjoys teaching yogalates.
"There's a synergy between them. They're both an art and a subtle science," she said. "Both focus on correct breathing, correct alignment and mindfulness."
Mindfulness is important, she added. "Our heads are always ruminating on the past or jumping ahead to the future. It's a treat to get 90 minutes to focus on your breath and your body in the present moment."
Edgar gives extra attention to "making yogalates accessible to every body. That's two words — every body. It's beneficial for people with restricted movements as well as elite athletes."
She's had an 11-year-old and an 82-year-old in her class. She's taught people with hip replacements and others who are in tip-top shape.
As the class progressed Friday, Edgar walked the room, helping various students adjust their movements and suggesting alternate movements for those with injuries or feeling discomfort in a certain position.
Giving slow directions while soft music played in the background, she had her students focus on their breathing. "Breath is the bridge between the inner and outer world," she said. "Slowly lengthen and deepen your breath."
Judy Bishop of Hendersonville, who has been practicing yoga for 10 years and Pilates for two, said she likes the yogalates combination. The movements might be slow and deliberate, but in the end "It energizes you. By working on my strength and balance I can do the other activities I like to do. I hike, I walk 3 miles every morning, I ride horses and hang glide. I like to take active vacations with activities like parasailing.
"Yogalates keeps me in shape so I can do that. I'm going to be 67 this year. After a yogalates class, I have energy for the rest of the day and evening."
Charles Brady, 73, of Hendersonville enjoys taking yogalates classes with his wife, Adrienne, 66. The two retirees have taken classes at the YMCA, also taught by Edgar, but on Friday they were at Brightwater.
Yogalates "works your core better" than yoga and is a little more strenuous, Charles said. When the class is over, "I feel energized and I don't feel any stress or strain." The exercise helps him stay strong for yard work and hiking.
Adrienne added, "It helps me feel looser, and I can do more." As the president of the local chapter of the National Alliance on Mental Illness, NAMI Four Seasons, Adrienne sais Yogalates "helps me deal with problems, because I'm mentally balanced."
Brightwater Yoga is located at 506 � Main Street in Hendersonville. It is open seven days a week, but hours vary. Call 828-698-5557 for more information or visit www.brightwateryoga.com.
Reach Tanker at 828-694-7871 or firstname.lastname@example.com.


text:
Friday's deadline for the former general manager of the Ross Valley Sanitary District, Brett Richards, to repay a $350,000 housing loan from the district passed with no word from Richards.
"No check, no UPS, no FedEx, no mail delivery of a check," said district board president Frank Egger.
The district board discussed the pending deadline in closed session before its meeting last Wednesday night. During that meeting, Egger announced the board had directed the district's attorney, Jolie Houston, on what action to take should Richards fail to replay the money on time; he didn't specify what that was.
Egger said Monday, "We directed counsel to initiate a process in order to make sure the taxpayers get their money back — at least do our best to get our money back. We're going to use every legal avenue open to the district to make our best attempt to get our money back."
District board member Mary Sylla said, "It isn't like it was a big surprise. He was supposed to be making payments. If he had been in good faith intending to pay, he would have been paying all along."
Richards repaid about $12,000 before ceasing to make payments last fall.
Sylla said, "I'm just glad that the district attorney is still pursuing it aggressively, and we're not spending ratepayer money on a private investigator to hunt him down."
Marin County District Attorney Ed Berberian said his investigation of whether Richards misappropriated public funds is ongoing. Under state law, misappropriation of public funds is a felony punishable by imprisonment for two, three or four years. Berberian said whether or not Richards repays the loan has no bearing on his investigation.
"We're looking at it from a different perspective — as to his use of public funds," Berberian said.
The district board awarded Richards the loan in October 2010 to assist him with "securing housing in the San Francisco Bay Area." District records show that Richards had the money transferred to his account in December 2010.
Richards resigned from his $197,000-a-year job in July after Marin Independent Journal columnist Dick Spotswood raised questions regarding whether Richards used the loan to purchase housing. Spotswood wrote that a search of all California's county recorder databases failed to unearth any evidence that Richards owns real estate in California. Richards has so far supplied no information to demonstrate that the money was used as intended.
Under the terms of Richards' contract, because he resigned he had six months to repay the $350,000 loan. Egger said Richards has so far returned about $12,000 and has made no payments since September or October.
After resigning, Richards began blogging about his past experiences in Marin from an undisclosed location in Florida; but that website has since been shut down without explanation.
Houston, the district's attorney, was asked by a member of the public Wednesday night if the district knows Richards' current whereabouts. Houston said she couldn't comment because of the ongoing criminal investigation.
"It's very serious," Houston said.
Contact Richard Halstead via e-mail at firstname.lastname@example.com


text:
Crowds wielding quarter-page red guidebooks meander around downtown streets in search of artistic gems as part of the San Francisco Museum of Modern Art's "Project Los Altos: SFMOMA in Silicon Valley." Although some of the creations unfold on screen or gallery walls, many of the project installations involve visitors in more immersive experiences.
The Town Crier team toured the sites during the inaugural weeks of the project and compiled an insiders' guide with navigation tips. Readers can clip the guide out, photograph it for cellphone viewing or even memorize it as a tool to impress guests. For a PDF version of our guide, click here.
Whether tackling one or two project installations at a time or all exhibits in one trip, lace up comfortable walking shoes for a modern-art treasure hunt.
"Project Los Altos" runs through March 2. Read the Town Crier for updates on special events scheduled during its stay.
Outdoor installations are open at all times. Indoor installations are open 10 a.m. to 6 p.m. Wednesdays through Sundays. For additional information visit sfmoma.org/exhib_events/exhibitions/572.
– Text and photos by Ellie Van Houtte
Indoor Installations
Costume Bank, 169 State St.
Mike Mills, "A Mind Forever Voyaging Through Strange Seas of Thought Alone: Silicon Valley Project"
• Enter through the Costume Bank, to its back room.
• Inspired by Silicon Valley's transition, Mills' installation includes a video of local youth describing their ideas of the future with short biographies and photos of eight people who work or live in the area.
• A copy of the April 1, 1976, Los Altos Town Crier enables visitors to review news events during the year Steve Jobs incorporated Apple Computer. A copy of Apple's incorporation papers is in the centerfold.
Tip: Mills collected pieces of clothing from the subjects included in his installation and displays the articles on a rack in the corner of the room. Look closely at the labels.
242 State St.
Jeremy Blake, "Winchester"
• Inspired by San Jose's Winchester House, built circa the 1880s by Sarah Winchester, who also owned the property that became the city of Los Altos. Blake's three-screen film seems more psychedelic than spooky.
Tip: Allow at least 10-15 minutes for viewing.
Spencer Finch, "Back to Kansas"
• Configured in the shape of a movie screen, the blocks of this colorful grid are inspired by the colors found in the movie "The Wizard of Oz."
Tip: View Finch's piece just before and after sunset. As the sun sets around 5 p.m., relax in one of the comfortable sofas as the squares fade to gray. Cards and pencils are available to allow guests to mark the times when the different colors disappear.
271 State St.
Christian Jankowski, "Silicon Valley Talks"
• Comfortable bright-green furniture invites guests to relax as they enter the dim space of Jankowski's installation.
• Filmed talks by nine local entrepreneurs – ranging from how to write a poem to falling in love and an introduction to fly fishing and vacation – challenge visitors to get lost in the artistic presentation of the spoken word.
Tip: Jankowski filmed the series earlier this month, and the presentation includes local residents.
359 State St.
Charles Garoian
• A Los Altos High School art teacher for 17 years, Garoian's slide show highlights nine performance-art pieces created with his students during his tenure.
Background article: "Former LAHS teacher Garoian inspired a generation of 'misfits'"
Katerina Šedá, "Everything Is Perfect"
• In Šedá's vision, every Los Altos or Los Altos Hills resident is someone with "ordinary characteristics and talents." Her installation involves the community as the primary subject of her artistic experiment.
• Unlike most of the other installations, Sedá's project is a work in progress. A physical desk with submission forms and a computer allow viewers to submit a record for inclusion in a "Los Altos World Record Book," scheduled for publication in the spring.
Tip: After visiting the submission desk, visit everythingisperfect.org to see some of the current entries, ranging from the Youngest Mayor to the Longest Knitting Pig Hat.
Background Article: "Project Los Altos artist collecting everyday records from residents"
Alec Soth
• Enjoy a unique glimpse of Silicon Valley through Soth's collection of black and white photographs.
• From obscure landscapes of tech headquarters to local residents in venues that defy the perceptions about the area, the collection illuminates iconic and everyday community scenes from a new perspective.
Outdoor Installations
Intersection of State and Fourth streets
Jessica Stockholder, "Cross Hatch"
• With an October unveiling, this street painting was SFMOMA's first "Project Los Altos" exhibit to arrive in town.
• The piece incorporates shapes that mimic the triangular shape of downtown Los Altos.
• Sitting in the bleachers adjacent to the installation, visitors can observe pedestrians, cars and other elements as they intersect with the artwork.
Tip: Consider climbing the stairs located on the Plaza Central side of 142 State St. for a unique photo angle.
Background Article: "Bold strokes on State Street draw colorful reaction"
Shasta and First streets
Chris Johanson, "If You Are Open to It, You Can Find a Sign That Can Be a Sign"
• Finding this installation by Johanson can be difficult, but if visitors pay close attention to the intersection, they can spot a green post jutting from a building on the north side of Shasta Street.
Tip: This piece is best examined by viewing from all angles.
Lincoln Park
Chris Johanson, "Door Sculpture to Talk About the Idea of Different Possibilities You May Have to Process Your Life"
• A series of three life-size doors open at different angles represents the opportunities for change that individuals encounter in life and their willingness to embrace them.
• Colorful frames entice visitors of all ages, especially children, who can be spotted wandering through the installation on the way to school in the morning.
Tip: Stop by the installation on a foggy morning to experience a sense of serenity and mystery. The vibrant doors seem particularly prominent to the eye as a blanket of fog fades the traffic of Foothill Expressway and the giant redwood trees of Lincoln Park into the background.
Village Park
Chris Johanson, "I Do Not Know But Am Open to Learning"
• Johanson's giant, inflated question-mark installation is easy to find.
Tip: Walk through and around the perimeter of the park to see how the landscape changes the way the sculpture is framed.
Civic Center Apricot Orchard
Chris Johanson, "The Field Became an Orchard Became a House and Became an Orchard (in Los Altos)"
• Surrounded by an orchard of trees, it's easy to miss this installation – a weathered door that rests on the ground. The door mysteriously seems to predate the tree growing through it.
Tip: As leaves change color and small yellow flowers blossom, November is the ideal time to visit the city's signature orchard to peek at the installation.


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Designer doesn't always have to mean expensive and unattainable. Many luxury labels are now offering a variety of high end gifts with low price points. TODAY's style editor and Bobbie.com's Bobbie Thomas highlights her favorite fashionable finds that won't break the bank this holiday season.Beauty buys
the season to score big with beauty. Many brands bundle their best for less into limited edition packages that make perfect presents. Sephora's Fragrance Sets for him and her include a keepsake box that opens to reveal a range of Sephora's best-selling fragrances which also includes a voucher for a full-size bottle, making it a perfect present when you're not sure what to choose ($50, Sephora.com).
Dior Holiday Palettes are a highly anticipated annual favorite thanks to the chic packaging. Their Deluxe Palette includes all the essentials you will need for creating smoky eyes to bold lips complete in a re-useable keepsake case ($46-$77, Nordstrom.com). Yves Saint Laurent offers an incredible value with the Sephora Holiday Glamour set. A collection of must-have products for the face, eyes, and lips packaged in a black faux patent leather clutch that can double as a clutch for a night out ($65, Sephora.com). Another perfect pairing is the Juicy Couture Hand Warmers & Deborah Lippmann Nail Polish Gift Set to help you to show off your mani in style ($68, Juicycouture.com). And finally, Chanel's Glossimer Duo Glosses gift set combines two of their popular shades along with a lip pencil and sharpener, all in a collectible cosmetic case ($55, Chanel.com).
Fashionable finds
For the men in your life, consider classic items they often forget to buy for (or upgrade) themselves. Coach offers a variety of accents for every man including essex herringbone wool scarves, heavy harness pebble belts in classic colors, and leather key rings with a hidden bottle opener ($48-98, Coach.com).
Iconic patterns add a little flair to his loungewear, and both Burberry's pajama pants ($95, Nordstrom.com) and Polo Ralph Lauren's flannel sleepwear and slippers ($24-$79, Macys.com) are great. For her, fashion truly meets function with Michael Kors colorful Continental wallets that zip-around and come boxed up in a sparkly bejeweled ($98, Macys.com). If you're looking for fashion forward affordable jewelry that doesn't feel like a dollar-store find but won't require a down-payment, Rachel Rachel Roy's and Givenchy's collections are impressive. Check out Rachel's notice-me-now vibrant geometric Pyramid pieces ($20-$95, Rachelroy.com) and Givenchy's bejeweled bangles and statement earrings ($35-$78).
For the preppy perky person (say that 5 times fast) on your list, Kate Spade's merino wool mittens feature fun cheeky phrases such as "Hi Five" and "Over Here", as well as with clever "Air Quotes" and "Taxi" designs that say a lot without saying a word ($65, Katespade.com). Last but not least, if you need a staple go-to-gift, DKNY's Trapper Hat and Infinity Scarf combine uptown luxe and downtown ease with a woven knit on one other side and faux fur trim on the other ($80, Dkny.com).
Hostess and home
It seems as if everyone today could use a "tech-sessory." And designers have all been eager to offer up their spin for your can't-live-without gadgets. Diane Von Furstenberg is personally obsessed with her iPhone and iPad, so she created cases adorned with her personal mantra "feel like a woman wear a dress" along with her signature bold DVF patterns and lips logo. Choose from USB key rings and ear buds, or peep her non-techy items like the decal coaster sets in beautiful bright prints inspired by nature and abstract art ($20-$38, Dvf.com).
You could also light up someone you love's life with a designer candle. Tom Ford, Balenciaga, and Salvatore Ferragamo are just a few that have infused their namesake scents into special flames ($56-$85, Neimanmarcus.com). For the true fashionista who dreams of her own Breakfast at Tiffanys, Amazon.com sells an assortment of collectible coffee table books from iconic designers like Alexander MQueen, Christian Louboutin, Prada, Gucci, and Louis Vuitton that always fit... on any table that is ($27-$95, Amazon.com). And if someone on your list is one of her 45 million fans, Lady Gaga teamed up with New York's beloved Barneys to create her own holiday collection filled with bizarre one-of-a-kind items like a painted chocolate skull, 'claw' and 'unicorn' stockings, collectible Gaga playing cards, and a Gaga Over Barney's snow globe ($25-$95, Barneys.com).


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Ricky Stuart vows to continue aggressive recruitment program at Canberra Raiders
Canberra Raiders coach Ricky Stuart has vowed to push forward with his recruitment program despite several marquee targets snubbing the club's advances and Wests Tigers fullback James Tedesco reneging on a three-year, $2 million deal.
But Stuart says he will only pursue players who "have pride in our jersey" and are genuine about playing for the Raiders, but some managers are trying to use big-spending Canberra as leverage in negotiations with rival NRL clubs.
Stuart is understood to be angry at the way the Tedesco deal collapsed on Wednesday night, despite receiving a personal call of apology from the 21-year-old fullback. Stuart has twice had players backflip on deals in the past two seasons, ironically representative forward Josh Papalii breaking a three-year deal with Stuart at the Parramatta Eels last year to remain in Canberra.
The Tedesco fiasco has raised doubts over Canberra's ability to attract marquee recruits, given Melbourne's Kevin Proctor and Penrith's Josh Mansour also turned down more lucrative offers from the Raiders to remain at their clubs. Veteran Bulldogs hooker Michael Ennis is also likely to turn down a Raiders approach and will instead join Cronulla.
But Stuart said the Raiders would not retreat from their recruitment campaign.
"When I was chosen for this job, which I regard as one of the privileged coaching appointments in the NRL, I recognised, as did our board, that we needed to recruit players in key positions that would add the necessary strength around the players on our existing roster," Stuart said.
"Despite the recent disappointments of losing players whom we had identified to fulfil these roles, I want to assure, in particular, our members and fans, stakeholders and the Canberra community that we will continue to push forward with an aggressive recruitment program that's aimed at bringing deserved success to a great football club. These disappointments have only added to our resolve to achieve our goals.
"The Canberra Raiders' recent disappointing recruitment results will not alter or affect this club's commitment to developing a successful football team in the future."
Proctor's decision to stay at Melbourne was the first big disappointment for the Raiders, given the Kiwi international had given Stuart a handshake agreement he was coming to Canberra.
The Raiders were more understanding of Mansour's circumstances, given his family commitments in the Penrith area, but are concerned Tedesco's backflip has created a stigma that suggests players don't want to come to Canberra. Stuart rejects that and remains confident he can attract players.
Outside backs linked in the media to the Raiders include the Roosters' Tautau Moga, Manly's Clinton Gutherson, Cronulla's Nathan Gardner and Tigers winger Marika Koroibete.
"The amount of names being linked to our club is incorrect, in many cases it's player managers trying to leverage our club to get their player more money," Stuart said.
Stuart made it clear that the Raiders would only negotiate with those who had genuine interest in playing for Canberra. "We want players at the Raiders who share our vision and who will have pride in our jersey," he said. "We have a clear and uncompromising plan ... the Canberra Raiders will continue to seek to bring success to our organisation."
Tedesco trained with the Tigers on Thursday before his return from a long-term ankle injury this weekend. Apologetic on Wednesday, Tedesco was smiling and relieved.
"It feels like a lot of weight lifted off my shoulders, I made that decision last week [to go to the Raiders] and I probably wasn't 100 per cent with it," Tedesco said. "In the end, it was too hard to do and I'm glad I can just stay."
Chris Wilson is the sports editor at The Canberra Times.
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GRAND RAPIDS, Mich. — Meijer is extending its fuel savings program will continue through the holiday, providing Meijer credit card customers with a 10 cent per gallon discount on fuel during the busy travel season.
The Grand Rapids, Mich.-based retailer's discount program is available at all 180 Meijer gas stations and will run through Jan. 5.
"Meijer is always looking for ways to save our customers money, especially during the holiday season," said Brian Horsford, director of gas stations. "Gasoline prices have a major impact on family budgets, so we are pleased to extend this savings opportunity to all Meijer credit card holders in time for their busy holiday travels."
Year round, Meijer credit card holders receive a 5 cent savings per gallon of gas purchased at Meijer gas stations.
The offer is valid at all Meijer gas stations and no minimum fuel purchase is required. Meijer currently carries three standard grades of gasoline, as well as diesel, kerosene and E-85 at most locations throughout its five-state region.


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A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success With Itraconazole But Not With Fluconazole
This study has been completed.
Janssen, LP
Information provided by:
NIH AIDS Clinical Trials Information Service
ClinicalTrials.gov Identifier:
First received: November 2, 1999
Last updated: June 23, 2005
Last verified: April 1996
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
To provide maintenance treatment with itraconazole solution for patients who were clinical responders in the ITR-USA-94 protocol, even if they subsequently relapsed.
|Candidiasis, Oral HIV Infections
|Drug: Itraconazole
|Study Type:
|Study Design:
|Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|An Open-Label Extension Study of Maintenance Therapy in HIV-Positive Subjects With Fluconazole-Refractory Oropharyngeal Candidiasis Who Have Responded to Itraconazole Oral Solution
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS Yeast Infections
Drug Information available for: Itraconazole FluconazoleU.S. FDA Resources
Further study details as provided by NIH AIDS Clinical Trials Information Service:
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Patients must have:
- Met criteria for clinical response on protocol FDA 236B with no residual visible lesion of oropharyngeal candidiasis upon completion of that study OR had initial response on protocol FDA 236B with subsequent relapse and retreatment with itraconazole solution or other therapies.
- Life expectancy of at least 3 months.
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms or conditions are excluded:
- Underlying clinical condition that would preclude completion of study or place subject at significant risk.
- Judged unreliable with respect to physician's directives.
Concurrent Medication:
- Rifampin.
- Rifabutin.
- Phenobarbital.
- Phenytoin.
- Carbamazepine.
- Terfenadine.
- Astemizole.
- Systemic antifungals.
Patients with the following prior conditions are excluded:
- Previously documented disseminated candidiasis.
- Previous clinically significant adverse event during treatment with itraconazole oral solution, unless clearly attributable to an intercurrent illness or condition.
- History of significant hepatic abnormalities or clinical evidence of significant hepatic disease within 2 months prior to study entry.
Prior Medication:
- Any investigational drug (other than itraconazole solution) within 1 month prior to study entry.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002341
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002341
|United States, Pennsylvania
|Buckley Braffman Stern Med Associates
|Philadelphia, Pennsylvania, United States, 19107
Sponsors and Collaborators
Janssen, LP
More Information
Keywords provided by NIH AIDS Clinical Trials Information Service:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
Moskovitz B, Wu J, Baruch A, Benken C. Long term safety and efficacy of itraconazole oral solution (IS) for treatment of fluconazole refractory oropharyngeal candidiasis (OC) in HIV-positive patients (pts). Conf Retroviruses Opportunistic Infect. 1997 Jan 22-26;4th:124 (abstract no 325)
Fessel WJ, Merrill KW, Ward D, Moskovitz B, Benken C, Oleka N, Grimwood H. Itraconazole oral solution (IS) for the treatment of fluconazole-refractory oropharyngeal candidiasis (OC) in HIV-positive patients. Conf Retroviruses Opportunistic Infect. 1997 Jan 22-26;4th:124 (abstract no 327)
|ClinicalTrials.gov Identifier:
|NCT00002341 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 2, 1999
|Last Updated:
|June 23, 2005
Keywords provided by NIH AIDS Clinical Trials Information Service:
Acquired Immunodeficiency Syndrome
AIDS-Related Complex
Candidiasis, Oral
Additional relevant MeSH terms:
HIV Infections
Candidiasis, Oral
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Mouth Diseases
Stomatognathic Diseases
Antifungal Agents
Anti-Infective Agents
14-alpha Demethylase Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Steroid Synthesis Inhibitors
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 CYP2C9 Inhibitors
ClinicalTrials.gov processed this record on September 25, 2017


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Mwaa! :heart: my sleepy time Abel I've had compleated for a while but just needed pics. Sadly had this compleated BEFOR my other Abel was even close.
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