text:
A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is a double-blind, randomized withdrawal study comparing CNV1014802 with placebo in patients with trigeminal neuralgia who have successfully responded to CNV1014802 in an initial open-label phase.
Patients will participate in an initial open-label treatment period of 21 days of CNV1014802 150mg three times a day (tid). Responders will be randomized to 28 days of CNV1014802 150mg tid or placebo.
Following an interim analysis after 10 evaluable patients have completed the open-label phase, the dose regimen may be increased to 350mg twice a day (bid) for the remainder of the trial if the responder rate is less than 60%.
|Trigeminal Neuralgia
|Drug: CNV1014802 Drug: Placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Phase IIa Placebo-Controlled, Double-Blind Randomized Withdrawal Study to Evaluate the Safety and Efficacy of CNV1014802 in Patients With Trigeminal Neuralgia
- The number of failures on CNV1014802 vs. number of failures on placebo during the double-blind treatment period will be the primary outcome of the study. [ Time Frame: 4 weeks ]
Patients will be classified as a treatment failure if they meet one of the following criteria:
- 50% increase in the frequency of paroxysms compared to the final 7 days of the open-label period
- 50% increase in the severity of pain experienced in the paroxysms compared to the final 7 days of the open-label period
- A Patient Global Improvement of Change rating of much worse/very much worse
- The patient discontinues the study due to 'Lack of Efficacy'. v. The patient discontinues due to an adverse reaction or poor tolerability considered to be related to study medication
- Secondary pain endpoints [ Time Frame: 4 weeks ]
- Number and severity of paroxysms of pain in the 21 day open-label period, both evoked and spontaneous
- Average 24 hour pain intensity numerical rating scale (PI-NRS)
- Patient and Physician Clinical Global Impression of Change
- Brief Pain Inventory - Facial
|Study Start Date:
|March 2012
|Study Completion Date:
|June 2014
|Primary Completion Date:
|March 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: CNV1014802
Drug: CNV1014802
CNV1014802 150mg tid for 28 days. Dose may be increased to 350mg bid following interim evaluation of efficacy.
|Placebo Comparator: Placebo
Drug: Placebo
Double-blind placebo comparator for 28 days.
Detailed Description:
In order to be randomised and enter the double-blind placebo controlled phase of the study, patients must satisfy at least one of the following criteria:
- 30% or more decrease in number of paroxysms (either spontaneous, evoked, or both)
- 30% reduction in the severity of pain experienced during the paroxysm (either spontaneous, evoked or both)
- A Patient Global Improvement of Change rating of much improved/very much improved The response will be compared with the baseline recordings of pain made in the 7 day run-in period. If a patient meets one of these criteria they are termed a responder, and will be eligible to be randomized into the double-blind treatment phase.
During the double-blind randomised phase, patients will be evaluated to determine if they meet the failure criteria at each clinic visit which will occur every 7 days in the double-blind treatment period. The number of failures on CNV1014802 versus number of failures on placebo during the double-blind treatment period will be the primary outcome of the study.
Patients will be classified as a treatment failure if they meet one of the following criteria:
- 50% increase in the frequency of paroxysms compared to the final 7 days of the open-label period
- 50% increase in the severity of pain experienced in the paroxysms compared to the final 7 days of the open-label period
- A Patient Global Improvement of Change rating of much worse/very much worse
- The patient discontinues the study due to 'Lack of Efficacy'
- The patient discontinues due to an adverse reaction or poor tolerability considered to be related to study medication
|Ages Eligible for Study:
|18 Years to 70 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female aged between 18 and 70 years, with a diagnosis of trigeminal neuralgia; IHS criteria to be used.
- Female patients must be of non-child bearing potential or agree to use an approved form of contraception
- Male patients must agree to use an approved form of contraception
- Body weight > 50 kg for men and > 45 kg for women.
- Capable of giving written informed consent. Informed consent must be obtained prior to the commencement of any study related procedures.
- QTcB either/or QTcF < 450 msec in two of three ECGs conducted at screening
- AST and ALT < 2xULN; alkaline phosphatase and bilirubin < 1.5xULN.
- Approved concomitant medications must have been stable for at least 3 weeks prior to day 0.
Exclusion Criteria:
- Patients who are known non-responders to sodium channel blockers at therapeutic doses.
- Patients with causes for their facial pain other than that specified in Inclusion Criterion
- A positive pre-study drug screen.
- A positive history of HIV.
- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 months of screening.
- History of any liver disease within the last 6 months, with the exception of known Gilbert's disease.
- History of excessive regular alcohol consumption within 6 months of the study.
- Patients with a history or risk of seizures or a history of epilepsy, head injury or related neurological disorders
- Patients with a history of uncontrolled or poorly controlled hypertension, with systolic BP frequently exceeding 160mmHg and/or diastolic BP frequently exceeding 100mmHg, or patients who have BP greater than or equal to 160mmHg systolic and/or greater than or equal to 100mmHg diastolic at screening after repeated measurements
- History or presence of significant cardiovascular, gastro-intestinal, or renal disease or other condition known to interfere with the absorption, distribution, metabolism, or excretion of drugs.
- Patients with conditions known to affect cardiac conduction or a personal or familial history of Brugada syndrome
- Pregnant females or lactating females.
- History or presence of any clinically significant abnormality in vital signs/ECG/laboratory tests or have any medical or psychiatric condition, which, in the opinion of the Investigator may interfere with the study procedures or compromise patient safety.
- History of suicidal ideation and/or suicide attempts or clinical evidence of recent major depression.
- Patients who are unable to maintain approved medications for their trigeminal neuralgia at a stable dose during the study.
- Unable to refrain from excessive use of sedatives.
- Unable to comply with the prohibited concomitant medication restrictions as detailed in the protocol. This includes but is not limited to sodium channel blockers or drugs that adversely interact with a monoamine oxidase-B inhibitor: MAOI's, antidepressants, opioids and sympathomimetic agents.
- History of hypersensitivity to CNV1014802.
- The patient has participated in a clinical trial and has received an investigational product within 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer) prior to the start of this study.
- Exposure to more than four new chemical entities (medications for which no marketing authorization has been obtained) within 12 months prior to the first dosing day.
- Where participation in the study would result in total donation of blood or blood products in excess of 500mL within a 56 day period.
- Patient is mentally or legally incapacitated.
- Unwillingness or inability to follow the procedures outlined in the protocol.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01540630
|United Kingdom
|Professor Joanna Zakrzewska
|London, United Kingdom
|Principal Investigator:
|Joanna Zakrzewska, MD
|University College Hospital, London, UK
|Responsible Party:
|Convergence Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT01540630 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 23, 2012
|Last Updated:
|October 29, 2014
Additional relevant MeSH terms:
Trigeminal Neuralgia
Trigeminal Nerve Diseases
Facial Neuralgia
Neurologic Manifestations
Nervous System Diseases
Peripheral Nervous System Diseases
Neuromuscular Diseases
Signs and Symptoms
Facial Nerve Diseases
Mouth Diseases
Stomatognathic Diseases
Cranial Nerve Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
Get Positive by Going Negative
As soon as I hit the send button on Tuesday's column, I knew my phone would be ringing. Sure enough, the phone rang off the hook last night with friends and associates wanting to discuss my views on earnings season (and the 2013 American League East). Most traders, and a majority of investors, focus on the quarterly earnings season as the be-all and end-all of markets. I politely disagree; it is just a check of vital signs in a long process. The inevitable question was eventually asked: If you were a trader, how would you approach the earnings season with an eye on turning a profit?
It is a fair question. I am not a trader, but I do spend a lot of time thinking about markets, talking about markets and researching stocks and markets. I hang out with many traders and other disreputable types and I have occasionally put on a trade or two. I could never do it full-time, as the time spent hanging on every tick cuts too far into my reading and baseball time, but I do know the game....619 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
Already a Subscriber? Please login.

subset: commoncrawl


text:
I finally got a chance to play around with these in a field last night in some stiff winds. I've been looking for something to get me some more D than my CFR PD's into the wind and I think I've found that in the PD2's. I have a production run PPD2 and a couple Euro Open CPD2's. The EO's are beefy and don't turn at all for me into a strong headwind. My PPD2 will track right into the wind and then come back to finish pretty straight for me. They were very reliable for me in the wind last night and seemed to net me an extra 40-50' over my CPD's.
I don't think I'll throw them a lot, but they definitely fill a role I've been looking for.... max distance into a headwind.


text:
Thank you. You should be receiving a reset link at the email address you provided shortly.
Pricing Information
Price description
Special Offer price
Special offer description 200 characters
Student rep info: name, email, ph #
Offered in partnership with
West Valley College
choose another school
A new session of each course opens each month, allowing you to enroll whenever your busy schedule permits!
How does it work? Once a session starts, two lessons will be released each week, for the six-week duration of your course. You will have access to all previously released lessons until the course ends.
Keep in mind that the interactive discussion area for each lesson automatically closes 2 weeks after each lesson is released, so you're encouraged to complete each lesson within two weeks of its release.
The Final Exam will be released on the same day as the last lesson. Once the Final Exam has been released, you will have 2 weeks plus 10 days to complete the Final and finish any remaining lessons in your course. No further extensions can be provided beyond these 10 days.
• Internet access
• Email
• One of the following browsers:
o Mozilla Firefox
o Microsoft Internet Explorer (9.0 or above)
o Google Chrome
o Safari
• Adobe PDF plug-in (a free download obtained at Adobe.com .)
Great course! This week I was able to contribute in a conversation about ODBC and API in a 3-tier environment. I couldn't do that before taking this course. Thanks!
Great illustrations of user data model, E-R model, MS Access, SQL, and Database Application using Access.
I am a very busy professional and I found this course to be EXACTLY what I needed to expand my knowledge areas. The instructor is very knowledgeable and was in-step 100% with the current industry leaders opinions and best practice recommendations.
I liked the course very much and it has changed my view (in a positive and constructive manner), on how to approach building a database. I especially liked the introduction to the course as it gave me an insight as to the background of students undertaking this course. This is especially interesting as students are from different parts of the world.
I thought the course was very interesting, and the way the course was formatted really got your attention. It shows that the instructor was very knowledgeable about the course. I would recommend it to anyone who is just learning Database Development, and even if you are familiar with the Developmental areas it can help you look at the process differently.
The course was very useful. I was designing a database when I took the course. With this information, I went back through the porcess and re-designed the database. It was greatly improved.
This course helped me to better understand the database software and how the components relate. The additional reading was very helpful.
This course was very beneficial to me in developing my professional skills.
This course was very helpful to me. It gave me a good start in developing a database of orders/parts/inventories. The lessons were well-written and easy to follow, but were also challenging.
Copyright © Education To Go. All rights reserved. The material on this site cannot be reproduced or redistributed unless you have obtained prior written permission from Education To Go. Education To Go and ed2go are registered trademarks of Education To Go, a part of Cengage Learning.
Cengage Learning
Copyright Notices
Terms of Use
Privacy Statement


text:
Forklift Rental In Arvada, Wyoming
For any business with a warehouse having a forklift is essentially for daily work.The easiest way of moving items around a warehouse and new shipments from the dock to the warehouse is with the help of a forklift.While it may be tempting to buy a new one for your business there are benefits associated with renting one for which you should consider.That said here are benefits of using a forklift rental.
A forklift rental may save you money
Using a forklift rental may save you lots of money especially if your business is new and may not have the luxury of operating huge budget.New forklifts may be expensive thus it is why you should consider using a rental one.If you don't have enough budget using a rental one will be a good way in cutting back on your expenses.
The lack
Leasing a lift truck may be more practical than purchasing a new one. if your business is of the type that sometimes is in need of a fort truck then you should consider using a rental one.If you were to purchase a new forklift it would just be sitting in the corner of your warehouse when it's not being used thus taking up valuable space.When you're in need of using fork truck sparingly it is advised you go for a leased forklift because You'll save money in the long run
No maintenance needed
A forklift rental Arvada, Wyoming lacks maintenance requirements.Just like any other fork truck which breaks down when excessively used. When yours breaks down you'll have to spend time and money on its repair.However, when you use a leased one you won't have to pay for maintenance work.The lack of additional work associated with forklift rental Arvada, Wyoming makes this an appealing option than owning your own.
For that, If you're considering to buy your own lift truck for use in your business then stop and consider the advantage of forklift rental Arvada, Wyoming before making your purchase.


text:
SOME of Winchester's most renowned style gurus have been on hand to give fashion ideas as part of Winchester Fashion Week.
The Slug and Lettuce was a hive of activity with clothes stands packed with the latest collections, tables bursting at the seams with Italian-leather handbags and row upon row of every kind of accessory money can buy.
Courtney Winstone, senior consultant for Captain Tortue women's clothing, said: "The event is all about discovering your style personality. It's a one-stop-shop for everything a woman could need – clothes, handbags and accessories. It's about looking at your body shape and looking at what colours you like.
"You don't have to be a slave to the catwalk. Most women want to keep up with the trends but stay true to their own style and it's about working to find the best look for you.
"This season we're finding there are a lot of yellows and pinks and purples coming in which don't necessarily work with everyone's skin tone but match it with some black jeans and a neutral-handbag and you'll be surprised what you can wear outside of your normal comfort zone."
Sarah Fitzgerald, owner of Beyond the Skin Handbags, said: "Not everything has to cost the earth so it's about affordability and fun and keeping up with the trends as well."
Winchester Fashion Week continues tomorrow with Dressing the Mums at Brides of Winchester between 4.30-8.30pm where mothers of the bride can get advice on outfits and hats. Phase Eight is also hosting a mini fashion show from 7-9pm in aid of the mayor's charity.


text:
The U.S. House of Representatives on May 28 voted to retain funding for the F136 engine General Electric and Rolls-Royce are developing for the F-35 as an alternative to the Pratt & Whitney F135. The FY11 Defense Authorization Bill contains $485 million for continuation of the engine, which is around 70 percent through its development program. The vote followed a mark-up to the bill by the House Armed Services Committee (HASC) that was agreed to on May 14.
General Electric was naturally delighted. "We applaud the HASC action," said David Joyce, president and CEO of GE Aviation. "Given the enormity of the JSF program, competing engines on the aircraft is the best way to put the acquisition reform act into action. With the growing concern over cost overruns in defense programs, competition continues to be the best cost-control mechanism." In an official statement the company went on to say, "We are pleased that the U.S. House of Representatives has once again voted in favor of the JSF competitive engine. This vote reaffirmed the Congress's strong and long-standing commitment to the F136 program. It is a win for competition and a win for the American taxpayers. The JSF competitive engine will save $20 billion over the 30-year span of the Joint Strike Fighter program, according to the independent Government Accountability Office."
However, the F136 continues to face concerted opposition, especially in the Pentagon. Speaking in late May at a Pentagon press conference, Rear Admiral Mike Manazir stated that the U.S. Navy would deploy only one type of engine in its JSFs that go to sea to optimize logistics and supply chains. Defense Secretary Robert Gates has also said that President Obama would veto the FY11 Defense Authorization Bill if it contains funding for the alternate engine.


text:
Topic: Intro
Hello everyone,
I was diagnosed with CC after being undergoing catscan for gallbladder problems. My bile duct was plugged due to a cancerous tumor. I underwent a whipple procedure at houston Methodist Hosp. The Surgery went fine and I recovered well. When I went in for chemo and radiation just for insurance, five weeks after surgery the cancer had mets to my liver. I started chemo ten days ago taking Xeloda (3500mg) orally.
I have had no side effects yet. I was wondering if anyone here is on Xeloda. I understand its relatively new, and it is expensive.


text:
According to Consumer Reports, while 3D TVs boast impressive technology, customers should hold off on buying them until the technology becomes more affordable.
The magazine found that, in tests of two Samsung LCD sets and a Panasonic plasma TV, 3D images had excellent depth, color, and high-def details, creating a compelling 3D picture as good as a movie theater. However, Consumer Reports added that customers who are happy with their current HDTV would be wise to wait until the price of 3D TVs drops and more 3D content becomes available.
"Blu-ray discs with 3D content are just arriving, and while 3D broadcasts are starting up it will be a while before there are many of them," said Paul Reynolds, electronics editor for Consumer Reports. "Though there isn't a huge price premium for the TVs, a 3D setup isn't inexpensive. For the sets we tested, you should figure on paying about $3,000 for the TV, Blu-ray player, and glasses for a family of four."


text:
Evolution Hoax
At the moment they are trying to stop destiny with all their might BUT THERE IS SOMETHING ABOUT DESTINY THEY DON'T KNOW: IT CANNOT BE STOPPED. In other words, you can shape a material, you can form a material into many things, but you cannot change destiny. THE THING ABOUT DESTINY IS THAT IT HAS A CRUSHING POWER. BY THE GRACE OF ALLAH, NOTHING CAN STOP IT.
2013-02-02 19:08:23


text:
Category: names for baby born in autumn
In what is fast becoming a nameberry tradition, we turn our attention to names of the new season. If you're expecting a fall baby, these choices might inspire you.
AUTUMN — Autumn is ironically the hottest season name, the only one in the Top 100 where it's maintained its status for over a decade now. The name Autumn first entered the U.S. Top 1000 in 1969, inspired by the hippie nature names and word names. While it's still attractive, however, it's hardly fresh.
Names from other cultures that provide a newer route to Autumn include the Japanese girls' names Aki and Akiko, the Turkish girls' name Hazan, the Vietnamese Thu, and, in Chinese, Qiu for either girls or boys.
Fall month names are not quite as usable as those of the other seasons.
SEPTEMBER – Why are March, May, August and even January hot while September (along with October, November, and December) is not? Maybe there's something chilly about that "ber" ending. Still, this has an attractive sound and is certainly unusual. The Latin Septimus, which means "seventh son," sounds a bit Harry Potter and is perhaps too redolent of things septic. But Seven (lets forget that September is the ninth month, since we still have November to deal with) has potential.
OCTOBER – An equally unusual month name that gets an extra helping of cool from hipster writers Dave Eggers and Vendela Vida, who chose it for their daughter. Perhaps more attractive are the Latin pair Octavius and especially Octavia, both of which mean (as does October) "eighth." Other Octavius and Octavia variations you might consider: Octavian, Octaviana, Octavienne, the Italian Ottavio or Ottavia, or the nicknames Tavy or Tavia.
NOVEMBER – Certainly as usable as September and October, which is to say, not very unless you're extremely adventurous.
Nature names that summon up an image of fall include tree names, particularly:
ASH (any of the Ash names – Asher, Ashley – relate)


text:
This is an article discussion thread for discussing the SitePoint article, "Using Regular Expressions in PHP"
This regular expression has a copule of problems. Firstly, I get a REG_ERANGE error and to fix this the '-' characters within the [] have to be escaped with a \. Secondly, three-part domain names fail, such as firstname.lastname@example.com following works better for me:^[a-z0-9.\-]+@[a-z0-9\-]+(\.[a-z0-9\-_]+)*(\.[a-z]{2,5})
worked fine for me, this is another alright insight to regex, ive been reading various different articles, this is another one that helped
Why do all the incorrect email matching expressions come up when you search for them on google. This is yet another example of how the author didn't completely do their homework to find out the complete matching expression for validating email. Sigh
A good overview of some of the possibilities with regex but as noted by others, many valid e-mail addresses will not be accepted by this regex string.It doesn't account for allowing an apostrophe in a user's name (which is valid according to the relevant RFCs) and it seems to not allow domain extensions such as .co.uk, .com.au or .info.
and it seems to not allow domain extensions such as .co.uk, .com.au or .info.
Have you checked the code for that? Do you think the author didn't check it? Of course it allows these domain extensions. I did the test and it worked. Just do it again and you will see... >:-(
This was the only place I could find that was able to explain the eregi function to me (php.net did, but didn't teach syntax). I don't believe the point of the tutorial was to give you a email validity checker, but that was rather an example of how you could use the code.
Very Helpful..thanks for taking the time to write this
I need to insert line breaks in the eregi expression, but I can't figure out what should I use there. The \ doesn't work..
I don't understand if the plus sign "+" requires one or more of the previous characters does'nt that mean if a user's email address does not have one of the characters, say a "_" or "-" then it will not validate?
Nice intro, well written but not exactly definitive. some links to further reading would be nice.
JohnKelly, the characters included inside the [] are the ALLOWED characters that an email address may contain. It doesn't mean that it must include all these.
The + character indicates that the username block of the address (the part before the @ sign) must have AT LEAST one character from the ones included inside the [].
will this ^[a-zA-Z0-9._-]+do for the user name checking..?
It probably won't, because it will just check if something is in the string, even when " characters (for instance) cannot be allowed.
I suggest something like^[a-zA-Z0-9_-.]{4,}$
as this means: at least 4 characters of a-z A-Z and 0-9 and _ - and .
note: please correct me if I got this wrong =P I'm no regex expert!
WOW, this is WEIRD!!
Seriously, when you look at your COMMENT BENEATH the article it ONLY states the following:
will this ^+do for the user name checking..?
Posted by: joby Oct 8th, 2005 @ 9:20 AM EDT
Then when I posted a reply I saw you actually posted the same I did just didn't include the $ at the end...
I'd still say my regex is a **** better than yours (otherwise folks might sign on with usernames like: ab, or __)
By the way, EVEN better is:^[a-zA-Z0-9]{1}[a-zA-Z0-9_-.]{3,}$
as it makes sure the FIRST character of a username is a letter or digit.. but whatever, it's all the same
note: again, correct me if I'm wrong... no expert!
Actually Quaint's regex would work better if it was:
If you're gonna use dashes (-) inside braces it must be put in the beggining or in the end, because it works like "From * to *", meaning that it would try to much every character between the ASCII representation of underscore (_) and the ASCII representation of the dot (.)
Good explanation! Thank you!
Hi this is great i can now create my own regular expresion. I would only reuse already made expression cos i did not understand how they come up with them. Thanx again
Good article, thanks.
Good article to start with Regular Expressions in PHP


text:
Best Home Interior Design Photos. Any dwelling could be gratifying with the correct application of basic interior design procedures. Some people study interior design to be excellent at it but there are people who are gifted with an eye for beauty and for interior designing. An individual who is creative can do some interior designing on his own even without formal training. Individuals who have an eye for what is aesthetic can just as easily decorate and design his own house depending on his tastes. Best Home Interior Design Photos Of course, it can help to read books and articles about designing to be updated on the basic and latest design approaches. Any interior designer can create a unique atmosphere simply by putting together several pieces and unifying them in one topic. There are interior designers who've a bias for particular motifs like eclectic, modern and even country style. Some go for simple designs without the litter.. Best Home Interior Design Photos.
Best Home Interior Design Photos. There are designers who specialize and use Feng Shui in their designs. This demands further study because Feng Shui deals with the Chinese's early methods of designing a space to really make the design work for the owner's health, business and other life factors. The Chinese believes a structure should be properly designed so as to permit positive energy to enter the structure. The mistakes can be corrected through proper interior design using the Feng Shui methods, when the structure has already been assembled without the aid of a Feng Shui expert. By featuring Feng Shui in interior design, it is believed that an individual can bring out all the positive energies in a space to make him rich, happy and healthy. An interior design using Feng Shui may also eliminate bad spirits that bring in negative atmosphere within an abode. Getting the services of an interior designer can make a space both aesthetic and functional. Any individual who desires to make his home livable and operational should try getting the services of an interior designer to optimize his space. Best Home Interior Design Photos
Copyright © 2016


text:
Animal lovers are being sought to help run a fundraising store in Otley.
Veterinary charity PDSA is seeking new volunteers for its busy shop on Kirkgate.
Store manager Antonia Pournara said: "A volunteer in our store will get to meet new people and add some valuable skills and experience to their CV.
"They will also be helping to raise much-needed funds for local pets in need.
"We are looking for people who are passionate about pets and can lend a hand, even if it's a few hours a week."
For more details about volunteering call the PDSA's National Volunteering Centre on freephone 0800 854194 or visit the website at www.pdsa.org.uk/ volunteering.
Anotonia can also be contacted at the Otley shop on (01943) 463371.


text:
Lindsay McGoran
I am currently in my last year of Honors in Biology at WLU, where I have found the faculty of science with their outstanding passionate professors, small class size and family environment has stimulated my passion for science. This fall in the lab I get the opportunity to study a wide range of Cuscuta species examining the pollen to ovule ratio (P/O), in order to hopefully see evolutionary trends in this genus breeding system. Outside of school I have many hobbies and interests I love sports especially running, skiing, snowboarding, and swimming. Enjoying being with friends and family spending time at my cottage and feel that traveling is one of the best ways to learn about the world and people around us.
If you have any questions involving what I do or study, please feel free to email me at email@example.com.


text:
McConnell Public Safety and Transportation Operations Center Featured on Channel 16
April 21, 2010
News Highlights
More Information
The McConnell Public Safety and Transportation Operations Center (MPSTOC) is featured as part of the Channel 16 program "County Magazine" this month. The MPSTOC feature also is available for viewing on the county Web site as well as the Fairfax County YouTube channel.
The full "County Magazine" program airs on Channel 16 at the following times:
- Sunday at 1:30 p.m.
- Monday at 6:30 p.m.
- Tuesday at 6:30 p.m.
- Thursday at 10:30 p.m.
- Friday at 3:30 p.m.
- Saturday at 3:30 p.m.
In addition to the MPSTOC feature, "County Magazine" also includes a brief overview of the 32nd annual Valor Awards with coverage of the Fairfax County Police, Fire and Rescue Department and Sheriff's Office, and a feature on the Department of Public Safety Communications (9-1-1 center), including recognition of National Public Safety Telecommunications Week, April 11-17.
For more information about the McConnell PSTOC, call 571-350-2100, TTY 711.
Contact: Merni Fitzgerald, Director, Office of Public Affairs
703-324-3189, TTY 711, Media Pager: 703-324-NEWS (6397)
To request this information in an alternate format, call 703-324-3187, TTY 711


text:
MLB.com Columnist
Bill Ladson
Werth stellar vs. old team at Citizens Bank
PHILADELPHIA -- Since joining the Nationals in 2011, outfielder Jayson Werth is hitting .267 with five home runs and 18 RBIs at Citizens Bank Park, his home field from 2007-10. But in just the past two seasons, Werth was 18-for-66 [.316] with four home runs and 11 RBIs there entering Sunday's series finale, when he homered in his first at-bat.
On Saturday night, Werth nearly put on a one-man show, hitting a home run, driving in three runs and scoring two runs in a 5-3 victory over the Phillies.
Since he has left the Phillies, Werth has heard a lot of boos from Philadelphia fans, even though he helped the Phillies win two pennants and one World Series title.
Asked after Saturday night's game if the boos pumped him up whenever he played at Citizens Bank Park, Werth said: "It's way in the background. It doesn't have any bearing on my game. I will say the first time I ever received a really good 'Werth-less' chant was in my sophomore year in high school in a basketball game. I pulled in 35 that night. So I'm up for a good 'Werth-less' chant."
Bill Ladson is a reporter for MLB.com and writes an MLBlog, All Nats All the time. He also could be found on Twitter @WashingNats. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Honolulu - Us Flag Canvas Tote Bag
Product Color:
Product information
Why get a Canvas Tote Bag Honolulu - Us Flag? Are you one of those that can't leave home without 50 "essential items" that just won't fit into your pockets? Plenty of room for all your necessities and more. Or simply let it speak your mind! Due to its sturdy fabric it also makes a great shopping bag, which lasts and saves the environment.
This Honolulu - Us Flag product includes a full side and bottom gusset and extra long handles for easy carrying. Honolulu Canvas Tote Bag made of sturdy 100% Cotton. Measurements: 15" x 18" x 6".
Sku: BL0BE0000010291616160381ABREBL000


text:
Corbett still considering Medicaid expansion for Pa.
Talks on a possible Medicaid expansion in Pennsylvania appear to hinge on a meeting that isn't on the governor's schedule yet -- as well as bickering over cost estimates and whether to trust a federal IOU.
Gov. Tom Corbett has said one of the reasons he's not deciding "at this time" to expand Medicaid is that he's not sure he can count on federal dollars to foot all of the costs in the first few years and most of the bill thereafter.
The acting secretary of the state Department of Public Welfare, Bev Mackereth, has borrowed the argument.
She says it's not wrong to doubt the federal government's ability to deliver on funding promises, because they've been broken before.
"Special education -- the commitment from the federal government was 40 percent, we're now down at 17," she said Wednesday. "I know you all are struggling with that piece in the education portion of your budget."
But Senate Democrats say it's disingenuous, arguing special education is not an entitlement program such as Medicaid, Medicare, or Social Security, which the federal government has a legal obligation to cover.
The governor, for his part, says he won't budge on Medicaid without more assurances from the feds. He plans to meet with U.S. Health and Human Services Secretary Kathleen Sebelius. So far, no meeting has been scheduled.
The bottom line, however, according to Mackereth is that "the governor did not say no. The governor said that we need to talk to the federal government about flexibility and reform."


text:
Tina Fey, Maroon 5 and More Join AMNH's 2012 Gala Tonight, 11/15
The 2012 Museum Gala will take place at the American Museum of Natural History tonight, November 15, with more than 600 guests expected to attend this year's event. As the institution's largest annual fundraising event, the Museum Gala helps advance its global mission to discover, interpret, and disseminate information about human cultures, the natural world, and the universe through a wide-ranging program of scientific research, education, and exhibition.
Following cocktails in the recently restored Roosevelt Rotunda, guests will enjoy a dinner menu created by Mario Batali and a performance by Maroon 5 in the Milstein Hall of Ocean Life. The event will be hosted by Master of Ceremonies, Tina Fey.
An auction of extraordinary prizes will be conducted by Jamie Niven of Sotheby's. The auction will highlight some of the best private experiences the Museum has to offer, including:
· A private astronomy lesson in the Hayden Planetarium and dinner (for 10) with renowned Astrophysicist Dr. Neil deGrasse Tyson
· Front row seats (for 25) to the Macy's Thanksgiving Day Parade on the Museum entrance steps, along with a private breakfast in the Roosevelt Rotunda under the famous Barosaurus and Allosaurus dinosaurs
· An "Ultimate Foodie Experience" - private dinner (for 10) in the Museum's new exhibition Our Global Kitchen: Food, Nature, Culture with curator Dr. Mark Norell
All Museum Gala attendees will be encouraged to make a donation supporting AMNH public school visits, which help the Museum open its doors to underserved children across the five boroughs of New York City.
Museum Gala chair are longtime Museum supporters Jodie and John Eastman, Tom Freston, and Alice and Lorne Michaels. This evening is presented by Graff Diamonds.
For tickets and information, contact the Department of Development 212-769-5932 or email firstname.lastname@example.com.


text:
A resource for reliable information about significant people, places, events, and things in Minnesota history.
Clement Haupers clowning around, c.1931.
Clement Haupers giving a lecture on the St. Croix river and displaying his paintings of the St. Croix area in the Livingston-Griggs Amusement Room, c.1969.
Clement Haupers in his studio, c.1930.
Clement Haupers in his studio, 1975.
Clement Haupers painting at Rutledge, c.1934.
Sullivanesque floral designs outside city hall, 2016.
Close-up of Morton gneiss used on the façade of the West Publishing Company building in St. Paul, 2016. Photograph by Paul Nelson.
Photograph of page in Polk County plat book (1902) showing locations of Carman's creamery, hotels, school, and artesian wells.
Faribault Woolen Mill Company textile sample book, c.1935.
Coach Department employees, Como Shops, Northern Pacific Railway, St. Paul, 1930. Photograph by R. E. Easthagen.
Made possible by the Arts and Cultural Heritage Fund through the vote of Minnesotans on November 4, 2008. Administered by the Minnesota Historical Society.
Minnesota Historical Society • 345 W. Kellogg Blvd., St. Paul, MN 55102-1906 (Map) • 651-259-3000 © .
Send questions or comments to mnopediamnhs [dot] org. View our Privacy Policy.


text:
You see the image of Steve Merfeld near the close of every basketball season, revisiting us as one of the ghosts of March Madness past. It's Bryce Drew, Christian Laettner, Tyus Edney and Merf. The others achieve amazing athletic feats each time we see them. Merf kicks his legs up in the air, pumps his fists and smiles.
A whole lot went into that moment, however. Merfeld coached the 2000-01 Hampton Pirates to a 25-7 record, which wasn't easy to do with a squad that played seven road games before Christmas. He compiled a 90-56 record in five seasons, which included another NCAA Tournament appearance, and then he did what so many other coaches do: He tried to climb the ladder.
He slipped off. He picked the wrong job at the wrong time, accepting an offer from Evansville at the time the Missouri Valley Conference was entering its strongest period since Larry Finch and Junior Bridgeman were chucking jumpshots around the league. It is a measure of the impression Merfeld made upon his opponents, though, that not one but two hired him to work as an assistant coach after he lost the Evansville job.
On Thursday night, Merfeld, 51, will be on the bench for Creighton, where he has been an assistant under coach Greg McDermott for three seasons, as the No. 16 Bluejays (7-1) play their first true road game at intrastate rival Nebraska (6-1).
Merfeld loves this job. He works with the coach's son, Doug McDermott, who is a first-team All-American candidate. He is responsible for the day-to-day management of the Creighton program, particularly when McDermott is recruiting or making community appearances. Merfeld wonders, though, if he'll again get the opportunity to be a head coach — to prove that night in Boise more than a decade ago was no fluke.
It's a pretty good situation. Creighton is one of the finest programs in Division I. Why not stick with this degree of security?
"I think just the fact — I don't want to live the rest of my life feeling that we didn't get it done at Evansville," Merfeld told Sporting News. "Personally, I know we did everything right, did a good job, just didn't do a good enough job. I would love to have another shot for my own personal satisfaction — just knowing we could do it again.
"As an assistant, you do a lot of recommendations. I want to get back to being a decision-maker, to taking the input from the assistant coaches and ultimately making the call again."
We have seen comebacks from coaches who lost their jobs. Paul Hewitt went almost immediately from Georgia Tech to George Mason. Gary Waters has gotten Cleveland State to three NITs and one NCAA Tournament since being dismissed at Rutgers. James Dickey is rebuilding Houston, though it took him nearly a decade to secure enough head coaching job after Texas Tech.
"High-major guys, when they get fired, they get other jobs," McDermott told Sporting News. "Guys that are mid-major guys are the ones who fall off the face of the Earth."
Tom Schuberth achieved one of the amazing turnarounds of the past decade, taking over Texas-Pan American when it just about had fallen off the Division I map. The Broncs were 3-24 against Division I opponents in 2005-06 and reached double-digit wins only once in the previous four years. He was 42-45 in three seasons, including 18-13 in his second year, but was fired over a curious personality class with an interim athletics director. He now is associate head coach Jacksonville State, helping James Green to rebuild a forlorn low-major program. In their third year together, the Dragons are 6-2.
Kirk Speraw made four NCAA Tournaments during his 17 seasons at Central Florida, but along the way UCF decided it wanted to upgrade from the Atlantic Sun to Conference USA. Even in the new league, he never was worse than 6-10 and he had three winning seasons in five tries. But he's now an assistant under Fran McCaffery at Iowa.
There are scores of such stories every year — I call it March Sadness — many with chapters less pleasant than what's become of Merfeld since he left Evansville. First, Bradley hired him as an assistant and then Creighton.
"I was always very impressed with Steve's teams at Evansville," McDermott said. "He just happened to be attempting to build a program in our league at the absolute worst time possible. Everybody in the league knew the quality of the coach he was and the job he was doing.
"He's a great teacher. I was always impressed with his front line guys, how fundamentally sound they were and their footwork — coming from this guy who's 5-foot-5 or whatever he is. And obviously he had great relationships with his players. For me, to have someone on staff who's been a head coach is invaluable. What I've found is, a lot of the little fires that pop up never get to my desk. He handles them before they ever become disruptive to my day."
Thursday's game at Nebraska will be important to Creighton's pursuit of a second consecutive NCAA Tournament bid — and probably essential to its maintenance of a top-25 ranking. As silly as the rankings might be, they can keep a program such as Creighton prominently displayed on ESPN television or in national publications and websites.
Merfeld will make his customary contributions in the pursuit of another key win for the Bluejays. When it's over, if Creighton wins, he's probably not going to charge to the opposite side of the court and be lifted in the air by one of the players. He'll walk across and shake hands with the opposing coaches and players.
Someday, though, he'd like to once again be first in that procession.


text:
I don't wear gloves and mine last. I am not a fan of OPI
Lovely range, but no.
This is me with Zoya. But I keep trying.
I have great luck with OPI - it and Sally Hansen are my two favorite nail polishes. I also like Essie a lot, but I get seven-day wear out of OPI and Sally consistently and Essie less so.
I don't wear gloves and mine last. I am not a fan of OPI
Lovely range, but no.
^ Henny, I adore that color!!
I got my Zoyas! I have Roxy on my fingers and Daul on my toes. If the glitter in Roxy were smaller, it would be total perfection. I still really, really like it. I like Daul, but not as much as I thought I would. I wish there were less gold glass fleck shimmer in it. (I can't believe I just said that either.) I like it, but I'll have to see it on my fingers before I make up my mind. Next mani on the docket is Zoya Kristen.


text:
An unusual gingival lesion: the resolution
Root-canal therapy and extraction options were given to the client, and root-canal therapy was desired to retain the tooth and avoid surgery. Although root-canal therapy is very successful, not all cases respond; additional therapy may be required. Pet guardians must be made aware of this.
Cast-metal alloy crowns generally are recommended for most root-canal procedures to protect the access site composite from breaking down and allowing microleakage of oral fluids into the pulp cavity (Photo 2).
Cast-metal alloy crowns help minimize the potential for access-site failure. Crown placement in this particular case was discussed. The recommendation for this patient was to wait until short-term resolution of the fistula could be documented and radiographic evidence of bone fill within the existing radiographic lucency could be appreciated.
Exploring the options
Now what are our options? Extraction is one very viable one. Redoing the root-canal procedure is certainly an option. Although the radiographic appearance suggests that the obturation is adequate, this does not ensure the perfect outcome.
A surgical root canal is a third option. A surgical (retrograde) approach will allow for immediate visual removal of all diseased periapical tissue including a portion of the root tip. This approach carries a higher possibility for success in this case.


text:
Kind of reminds me when people repeat crazy **** Faux News says and then deny watching the channel. "Derr I don't watch Faux!" Um. Yes. you. do.
'); var yuipath = 'clientscript/yui'; var yuicombopath = ''; var remoteyui = false; } else // Load Rest of YUI remotely (where possible) { var yuipath = 'http://yui.yahooapis.com/2.9.0/build'; var yuicombopath = 'http://yui.yahooapis.com/combo'; var remoteyui = true; if (!yuicombopath) { document.write('
Kind of reminds me when people repeat crazy **** Faux News says and then deny watching the channel. "Derr I don't watch Faux!" Um. Yes. you. do.
Anyway, I think we may have some issues here on term, if it came down to a last second three, and the player I picked had to take it, I'd pick Joe Johnson because he is a better shooter, but in terms of clutch play, which is stuff other than just shooting, I'd take the more complete player. Lebron is a 5 tool player, maybe the only one in the NBA (Scoring, ball handling, passing, defense (on ball and team), and rebounding) and he does all of them very well in late game situations, just because he does not always take the last shot does not mean he is just clutch.
As far as letting everyone "pat me on the back", I've tried to address everyone of your posts directly and hold a conversation between you and me as well. Honestly, I was interested to see if anyone else would go out on the same limb as you, not ridicule you just so that's on the record. Like I said if we're taking a game winning three pointer, this conversation may change a bit.
Last edited by Trader Joe; 08-14-2012 at 09:05 AM.
I will say, though, I enjoy hearing anyone bash any media type. It is one thing to figure it out, but after a while it should be ovbious every media base has a bias. Fox news (leans right), CNN (or if you would prefer controlled News Network to go with your "faux news") MSNBC (leans stupid as of late), ESPN (leans whatever Stern asks...)...they all have a bias
Read my prior post. I was makin' fun of the people who deny watching ESPN while repeating every ******** story line.
Depends if you need a 2 or a 3 to win
If there are eight posters on this board who want to be murdered, then I hope this isn't real life.
I would like to help a couple of them out with that..... ...
That was a joke, TJ..... ...
LeBron James. I think he's escalated past his "hated by the Gods" phase, and now he's just here to play basketball and win games. It's kind of a given fact that he managed to "turn on" his clutch mode in the playoffs this past season, and WILLED the Heat to a championship. Besides that, I just don't like Joe Johnson, and I think he's both one of the most underrated and overrated players in the league. He doesn't get many looks from critics, hence underrated. But he's way overrated in that he got a contract that is beyond the border of insanity.
LeBron gets this one.
witters: @imbtyler, @postgameonline
This thread is almost as retarded as having Ron Artest back as a Pacer.


text:
Kristen Wiig's Cover Shoot Style
Few women can pull off short and tight quite like Blake Lively. All taut body and flowing blonde hair, she's every man's dream and the envy of every woman. But Lively's pet Maltipoo, Penny—whom she rarely leaves home without—keeps the sexiness in check. While the minuscule pup is ridiculously adorable, she is, nevertheless, a dog. Her canine instincts must be obeyed. On the set of our cover shoot, the pup marked her territory dangerously close to an ivory Versace gown. (Hey, at least the girl's got great taste.) Beau Ryan Reynolds' mutt, Baxter, was also there. He lazed about while the ladies played dress-up. Lively worked with the MC fashion team to style heavily embellished gowns with glittering Lorraine Schwartz jewelry. And Penny was treated to a new plaid collar fetched especially for the occasion. Fashion hounds—they travel in packs. — Katie L. Connor
Dress, price upon request, Marios Schwab; bra, $140, Rituel by Carine Gilson; ring, price upon request, Lorraine Schwartz.
Shoes $3,255, Giuseppe Zanotti; (212) 650-0455.
Blake Lively: Evolution of a Style Icon


text:
'O'Connell said the Jillson deal actually began with San Jose wanting to get him back. But the Sharks changed plans after forward Marco Sturm was hurt, and focused on Buffalo center Curtis Brown. And Jillson ended up in Buffalo, set to face the Bruins tonight and again Saturday afternoon at the FleetCenter.'
You are here: Home / SabresBeat / Boyes' offense the key


text:
CAPPING Bromley people's benefits could drive them into a life of crime as they struggle to survive and support their families, it has been claimed.
The borough has been selected to trial the coalition government's reform to the benefit system where from April 1 households will see their benefits capped at £500 a week.
James Smith and Ben Martin fear what will happen once the cap comes in as they say it is hard enough for people to survive on the benefits they receive at the moment.
Mr Smith, of Widmore Road, Bromley, says he gets about £56 a week employment support allowance and has not had a job since he left The Priory School about three years ago.
"I think they have not done enough to help people.
"There are so many people stealing and they have to do it to survive.
"The government needs to seriously think about what they are doing because people cannot afford to exist.
"They were saying they were going to do a millionaire tax and if they did that there would be more money for everyone else."
The 19-year-old wants to be a chef or in the army and would be in favour of national service if it was brought back in.
"I think they should bring back national service, for two years after school to make you a man."
His friend Ben Martin, 20, says it is very difficult for him and his girlfriend to bring up their baby on benefits: "By the time we do the shopping and pay for gas and electric there is no money for travel or anything.
"Your family do not give you money because they are in the same position and they are just trying to survive."
Mr Martin, of Turpington Lane, Bromley Common, added: "People rob and get put in prison just to survive."
He wants to work as a labourer but says he cannot afford to take the construction skills certification scheme course he needs to prove he is competent on a building site.
A Department for Work and Pensions spokesman says Bromley was chosen as a trial area because it represents a good cross section of the benefits claimed.
He added: "It cannot be fair that benefit claimants can receive higher incomes than families who are in work – in some cases more than double the average household income.
"The benefit cap sets a clear limit to what people can expect to get from the benefits system and will tackle the problem of welfare dependency."
The benefits cap explained
The borough has been selected to trial the coalition government's reform to the benefit system from April 1 – along with Croydon, Enfield and Haringey.
From this date couples (with or without children living with them) will have their benefits capped at £500 a week.
Single parents whose children live with them will receive a maximum of £500 a week.
And single adults who do not have children, or whose children do not live with them, will get their benefits capped at £350.
Who will be affected by the benefits cap?
The cap applies to the total amount people in a household get from the following benefits:
- Bereavement Allowance
- Carer's Allowance
- Child Benefit
- Child Tax Credit
- Employment and Support Allowance (unless you get the support component)
- Guardian's Allowance
- Housing Benefit
- Incapacity Benefit
- Income Support
- . Jobseeker's Allowance
- . Maternity Allowance
- . Severe Disablement Allowance
13. Widowed Parent's Allowance (or Widowed Mother's Allowance or Widows Pension you started getting before 9 April 2001)
Who will not be affected by the cap?
The benefit cap will not affect people who qualify for working tax credit or who get the following benefits:
- Disability Living Allowance
- Personal Independence Payment (from April 2013)
- Attendance Allowance
- Industrial Injuries Benefits (and equivalent payments as part of a war disablement pension or the Armed Forces Compensation Scheme)
- Employment and Support Allowance, if you get the support component
- War Widow's or War Widower's Pension
What do you think of the benefits cap? Have your say below.


text:
- Home
- |
- Get Support
- |
- Locations
- |
- Pay My Bill
- |
- Check Webmail
Cotter and Gassville
All rates for service are on file with the Arkansas Public Service Commission. These rates and the Arkansas Public Service Commission rules are on display and available to the customer on request at our Business Office.
The tariffed rates for basic exchanged service are:
*Lifeline is a government assistance program developed to help low income residential customers receive local telephone service at a reduced rate. Eligible residential customers will receive a reduced monthly rate for basic telephone service and do not pay the monthly subscriber line charge. Reductions do not apply to installation charges, long distance services or calling features. Lifeline is available to food stamp, Medicaid, Temporary Assistance to Need Families (TANF), Federal Public Housing Assistance (Section 8)/ HUD, Low Income Energy Assistance Program (LIHEAP), National School Lunch (SNL) Free Program or Supplemental Security Income (SSI) recipients as well as customers whose income is at or below 135% of the Federal Poverty Guideline (FGP). The Lifeline program is limited to one discount per household.
Billing Procedures
Bills are issued monthly and include local service for one month in advance, appropriate charges for long distance calls and any other charges incurred since the previous billing. The bills are mailed on the last day of the month for the next month's service.
All bills are due by the close of business on or before the 22nd day of each month. Customers whose bills are not paid by the due date will receive a "Shut-Off Notice" stating the last day to pay before service will be suspended. Once suspended, the full delinquent amount, plus a reconnection charge, must be paid before service will be restored.
A residential customer may designate a third party to receive a copy of any "Shut-Off Notice."
Suspension of service may be delayed when a "Certified Medical Emergency" exists or when a "Delayed Payment Agreement" has been entered into with the Company. These options are available through the local Business Office.
Residential customers may qualify for our "Extended Due Date Plan." A due date may be changed to coincide with or follow the customer's receipt of income. Customers who qualify under this policy and pay by the new date will not be considered late on their payment. The following customers may qualify for the plan:
1. Persons receiving Aid to Families with Dependent Children (AFDC), Aid to the Aged, Blind and Disabled (AABD), or Supplemental Security Income.
2. Also, persons whose primary source of income is Social Security of Veterans Administration disability or retirement benefits.
During periods of extended absence customers may elect to pay their bill in advance. The advance payment will be based on the customer's average monthly bill for the most recent twelve months. Payments may also be made automatically by enrolling in the Company's bank draft plan. The customer can arrange to have bills mailed to an alternate address or third party during the absence.
Contact our Business Office for further information regarding our "Extended Due Date Plan" or "Extended Absence Plan."
Delayed Payments
If you are unable to pay a bill in full, the Company will not discontinue service if you qualify for a delayed payment agreement and:
1. You pay a reasonable portion of your bill; and
2. You agree in writing to pay the balance of your bill in reasonable installments; and
3. You agree in writing to pay in full all future bills during the period of the agreement by due date.
YELCOT may not require more than ¼ of the overdue bill as the initial payment, and will allow equal installments for at least 3 months from the date of initial payment.
In arranging the installment payment agreement, the Company will consider the customer's ability to pay, the size of the unpaid account, the customer's payment history, and the length of time and reasons the account has not been paid. You must contact the Company by the close of business on the last day to pay printed on the "Shut-Off Notice" to arrange an agreement. The Company may charge interest on the unpaid account. The Arkansas Public Service Commission will set the interest rate annually.
If a utility bills a customer for an amount to correct a previous under billing, the customer is permitted to pay that amount pursuant to a delayed payment agreement that provides for repayment over a period equal to the period during which the under billing occurred. If the under billing is the fault of the utility or it is impossible to determine whether the previous under billing is the fault of the utility or the customer, the utility will not impose a finance charge on the delayed payment.
Payment of Bills
In person:
-Contact our Business Office (870)435.6111


text:
Hey all,
Beginner's question here. I've been meditating daily for a few months, and I've discovered something interesting. I am actually getting quite good at focusing on the breath in and the breath out. It is something concrete to focus on. My trouble is that I tend to lose focus during the empty space in between breaths. Sure, sometimes I naturally breathe fluidly, one breath after the other, and those times are quite easy to focus during. But more often than not, I find that my natural breathing is more sporadic. I will breathe, and then I will be at rest without breathing for several seconds. I am trying to follow the breathing meditation style that follows the natural breath rather than regulating my own breathing rhythmically. And I guess sometimes my natural breathing is choppy and non-fluid.
So for the experienced meditators, does this sound familiar? Or should I try to figure out why my breathing is not so fluid while meditating? It seems so weird that I am totally okay with focusing on the breath but that the spaces in between are causing my mind to wander off. Anyway, sorry for rambling. But I am just trying to see if this has happened to anybody else. Thanks for reading.


text:
Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)
This study is ongoing, but not recruiting participants.
Satish R. Raj
National Center for Research Resources (NCRR)
Information provided by (Responsible Party):
Satish R. Raj, Vanderbilt University Medical Center
ClinicalTrials.gov Identifier:
First received: June 2, 2008
Last updated: March 22, 2017
Last verified: March 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects. In this pilot study, we will test the null hypothesis (Ho) that there are no differences in the sleep quality between patients with orthostatic intolerance and healthy control subjects.
|Postural Tachycardia Syndrome Orthostatic Intolerance Sleep Disorders
|Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
|Study Type:
|Study Design:
|Observational Model: Case-Control
Time Perspective: Prospective
|Official Title:
|Assessment of Objective Sleep Disturbances in Orthostatic Intolerance Using Actigraphy
Resource links provided by NLM:
MedlinePlus related topics: Sleep DisordersU.S. FDA Resources
Further study details as provided by Satish R. Raj, Vanderbilt University Medical Center:
Primary Outcome Measures:
- Sleep Latency [ Time Frame: 1 week ]
Secondary Outcome Measures:
- Sleep Efficiency [ Time Frame: 1 week ]
- Wake After Sleep Onset [ Time Frame: 1 week ]
|Estimated Enrollment:
|Study Start Date:
|June 2008
|Estimated Study Completion Date:
|December 2018
|Estimated Primary Completion Date:
|December 2018 (Final data collection date for primary outcome measure)
|Assigned Interventions
Patients meeting the diagnostic criteria for the Postural Tachycardia Syndrome, a form of Orthostatic Intolerance
Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
Watch to be worn on wrist for 7 days (except in water) that will measure activity/movement.
Other Name: ActiWatch from Minimitter
Healthy control subjects who do not meet the criteria for the Postural Tachycardia Syndrome
Device: Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
Watch to be worn on wrist for 7 days (except in water) that will measure activity/movement.
Other Name: ActiWatch from Minimitter
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
Patients diagnosed with the Postural Tachycardia Syndrome. The criteria include:
- an increase in heart rate on standing (from supine) of >30 bpm
- in the setting of symptoms of cerebral hypoperfusion that are worse with standing and better when recumbent
- the symptoms are daily or almost daily
- the symptoms are chronic (lasting greater than 6 motnsh)
Inclusion Criteria:
- Diagnosed with orthostatic intolerance by the Vanderbilt Autonomic Dysfunction Center
- Control subjects will be free of orthostatic intolerance and other major medical problems, free of medications during the study
- Age between 18-65 years
- Male and female subjects are eligible.
- Able and willing to provide informed consent
Exclusion Criteria:
- Overt cause for postural tachycardia (such as acute dehydration)
- Self-report of pregnancy
- Inability to give, or withdrawal of, informed consent
- Other factors which in the investigator's opinion would prevent the subject from completing the protocol
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00692471
Please refer to this study by its ClinicalTrials.gov identifier: NCT00692471
|United States, Tennessee
|Vanderbilt University
|Nashville, Tennessee, United States, 37232-2195
Sponsors and Collaborators
Satish R. Raj
National Center for Research Resources (NCRR)
|Principal Investigator:
|Satish R Raj, MD MSCI
|Vanderbilt University
More Information
Additional Information:
Keywords provided by Satish R. Raj, Vanderbilt University Medical Center:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
|Responsible Party:
|Satish R. Raj, Assistant Professor of Medicine & Pharmacology, Vanderbilt University Medical Center
|ClinicalTrials.gov Identifier:
|NCT00692471 History of Changes
|Other Study ID Numbers:
K23RR020783 ( U.S. NIH Grant/Contract )
|Study First Received:
|June 2, 2008
|Last Updated:
|March 22, 2017
Keywords provided by Satish R. Raj, Vanderbilt University Medical Center:
Orthostatic tachycardia
Additional relevant MeSH terms:
Sleep Wake Disorders
Postural Orthostatic Tachycardia Syndrome
Orthostatic Intolerance
Pathologic Processes
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders
Primary Dysautonomias
Autonomic Nervous System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
Everyday Energy Efficiency
0 comments / Apr 12, 2012
Raindrops… they seem innocent, right? They're tiny and light-weight so what harm can one little raindrop do? The answer? Never underestimate your opponent! Remember the story of David and Goliath? I think it's human nature to think the giant always wins and the little guy doesn't matter. You see, in the David and Goliath story oneRead more


text:
City should think twice about race fees
There is an old saying about stepping on a quarter while the dollar blows away. I'm afraid that is just what the city of Charleston is doing if it implements its planned fee structure for local races.
I've been an avid runner for the past two years. As a working father of three it is something that I have found is both very cost and time efficient as a way to get exercise. I try to run one local race per month as a way to motivate myself to keep running while giving to worthwhile local charities at the same time.
Usually when I run my wife and kids, sometimes my parents too, come to cheer me on. Afterward we typically eat at a local restaurant and/or enjoy whatever the local scene has to offer, especially if the race ends at the levy or Capitol. When you factor in my individual race entrance fee, parking, eating out for five to seven people, my family typically spends a decent amount of money in downtown Charleston on race day.
If the city council implements the race fee many races will have to relocate. The smaller ones like the Childhood Language Center's July 4 run and the Junior League's Pumpkins in the Park races will have to relocate (or worse yet cease) to places like Kanawha State Forest or Coonskin Park. While both are nice places there is little chance people will spend money locally like they would at the downtown races.
Charleston should realize what a tremendous asset we have that there are so many races. Last year's Komen Race brought in more than 6,000 runners, and the Charleston Distance Run brings at least that many if not more. When you count the number of spectators and family members that's a lot of money being spent in Charleston on meals, hotel rooms, etc. It would be a shame to lose that economic impact which I'm sure is more substantial than what it cost the city to close the streets for the race.
Finally, races' impacts are not just economic. Charleston has unfortunately been listed as the Most Miserable City in America by a recent Gallup Poll. Two of the six factors that led to this were physical health and healthy behaviors. Charleston should be embracing something like running that is obviously gaining in popularity substantially and not hinder its growth. Before any decisions are made there should be some public studies as to what the true economic impact of these races is and what other cities have done with similar situations. Races are not "problems;" they are solutions.
Taylor W. Raab
Vet showed affection for family, pet
If you have ever loved and lost a pet, you understand the intensity of the pain and grief you feel once they are no longer with us. We rescued our Ms. Taylor eight years ago from the Kanawha Charleston Humane Association Animal Shelter and were devastated when she was diagnosed in September with an inoperable brain tumor.
We write this letter with the greatest degree of admiration and appreciation of Dr. Julie Starcher and the staff at the Cross Lanes Veterinary Hospital. After Ms. Taylor was diagnosed, Dr. Julie and Andrea called biweekly from September to April to check on her condition and to see if we had questions or needed to be seen. They made us feel as if we were the only family going through this ordeal and shared every bit of grief we were experiencing. Dr. Julie showed us so much compassion and was with us throughout and even up to the end.
Dr. Julie is truly blessed with a gift of sincere love and affection for animals and the people who love them, which is the perfect match for the profession she has chosen. We will be forever grateful,
Chuck and Minnie Jones


text:
Symptom Tracking in Assisted Reproductive Technologies (START)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study assesses risk factors for depressive relapse in women undergoing fertility treatment with histories of major depressive disorder (MDD) or bipolar disorder. The study is focused on the acute risk factors of depressive relapse.
The investigators hypothesize that risk for depressive relapse will be greater among women who stop antidepressants compared to those who continue treatment with these agents.
|Depression Relapse in Women Undergoing Fertility Treatment
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Symptom Tracking in Women With a History of Depression Going Through Infertility Treatment.
- Depression relapse [ Time Frame: six months ]
Biospecimen Retention: Samples With DNA
|Estimated Enrollment:
|Study Start Date:
|October 2012
|Estimated Study Completion Date:
|August 2017
|Primary Completion Date:
|June 2016 (Final data collection date for primary outcome measure)
Women currently taking antidepressants
Women who have selected to stay on antidepressant medication while undergoing infertility treatment.
Women not on antidepressants
Women who decided to discontinue their antidepressants while undergoing fertility treatments.
Detailed Description:
This study hopes to address the following aims:
Specific Aim #1: To delineate the relative risk of relapse in women undergoing IVF, IUI, or other infertility treatments who discontinue antidepressant therapy for depression, compared to those who maintain treatment with these agents.
Hypothesis: Risk for depressive relapse will be greater among women who stop antidepressants compared to those who continue treatment with these agents.
Specific Aim #2: To identify predictors of depressive relapse among women receiving IVF, IUI, or other infertility treatments
Hypothesis: Relapse rates will be greater among those who have: 1) histories of more recurrent depressive illness, 2) longer duration of attempt to conceive, and 3) a lower degree of perceived support from respective partners.
Specific Aim #3 (exploratory): To describe the trajectory of depressive symptoms in women with histories of depression across the course of IVF, IUI, or other treatments.
Hypothesis: Specific phases of the IVF cycle will have differential effects on the burden of depressive symptoms. Specifically, these phases include: 1) the phase prior to egg retrieval, 2) the phase after embryo transfer while a woman waits for the pregnancy test or her menstrual period, and 3) the phase after the experience of a negative pregnancy test (when applicable) following an IVF cycle. We seek to characterize factors associated both with vulnerability to more depressive symptoms and to resilience in the context of the different phases of IVF treatment.
Specific Aim #4 (exploratory): To identify biological markers of stress, including HPA axis dysregulation and inflammation associated with depressive relapse, during IVF, IUI, or other infertility treatments
Hypothesis: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation, evidenced by increases in diurnal salivary cortisol patterns and markers of inflammation, will be associated with higher
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- Have a history of a MDE or bipolar disorder prior to starting fertility treatment.
- Have received consultation around infertility treatment and plan to start fertility treatment.
Exclusion Criteria:
- Use of corticosteroids within 1 month of enrollment.
- Presence of any endocrine or autoimmune disorder, other than hypothyroidism well-treated for at least 6 months.
- Current episode of depression or mania.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01746797
|United States, Massachusetts
|Massachusetts General Hospital
|Boston, Massachusetts, United States, 02114
|Principal Investigator:
|Marlene F Freeman, MD
|Massachusetts General Hospital
|Principal Investigator:
|Lee S Cohen, MD
|Massachusetts General Hospital
|Responsible Party:
|Marlene P. Freeman, MD, Director of Clinical Services at the Center for Women's Mental Health, Massachusetts General Hospital
|ClinicalTrials.gov Identifier:
|NCT01746797 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 7, 2012
|Last Updated:
|June 8, 2017
Keywords provided by Marlene P. Freeman, MD, Massachusetts General Hospital:
fertility treatment
Additional relevant MeSH terms:
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
Antidepressive Agents
Psychotropic Drugs
ClinicalTrials.gov processed this record on September 20, 2017


text:
The Japanese scientists used a previously established model of transient cochlear ischemia for the study. In
this model the vertebral artery of gerbils is occluded for 15 minutes in order to provoke transient cochlear
ischemia, followed by reperfusion. As presented in earlier publications, this leads to irreversible loss espe-
cially of inner hair cells and permanent hearing loss especially at higher frequencies. 10 µl of AM-111 at a
concentration of 1, 10 or 100 µM and formulated in a gel was placed onto the round window membrane 30
minutes after the insult. The gel without active substance served as control. For the evaluation of the audi-
tory function, auditory brainstem responses (ABRs) were measured at 2, 4 and 8 kHz before ischemia, as
well as 4 days and 7 days after the temporary arterial occlusion. Animals were sacrificed on day 7 for histo-
pathology and counting of hair cells.
In control ears mean ABR thresholds increased substantially to day 4 (+31 dB at 8 kHz, the most sensitive
frequency) and from there recovered slightly to day 7 (+25 dB at 8 kHz). In contrast, ears treated with AM-
111 showed less hearing loss the higher the applied concentration was. At the highest concentration, mean
ABR thresholds in AM-111 protected ears rose by only 7 dB to day 4 and were elevated by 3 dB on day 7.
Statistical analysis (one-way analysis of variance followed by Fisher's post hoc test) revealed statistical sig-
nificance of the otoprotective effect of AM-111 at all 3 concentrations (p < 0.01 at 100 and 10 µM, and p <
0.05 at 1 µM). The protective effect was confirmed by histopathology: inner hair cell loss on Day 7 in the
most affected basal turn amounted to 13.3±2.7% in controls and 3.1±0.6% in the highest concentration
AM-111 group. The difference was statistically significant in a concentration dependent fashion (p < 0.01 at
100 and 10 µM, and p < 0.05 at 1 µM).
About acute sensorineural hearing loss
Acute sensorineural hearing loss (ASNHL) or inner ear hearing loss is the consequence of various insults to
the cochlea. It may result e.g. from overexposure to noise, bacterial or viral infections, inflammation, vascu-
lar compromise, or a variety of other factors. In ASNHL, sensorineural structures of the inner ear – inner and
outer hair cells, neurons – are damaged, as well as other structures such as supporting cells or vascular
tissues. The common observation is a temporary increase in hearing thresholds, i.e. hearing loss. Thanks to
cellular defences and intrinsic repair mechanisms, a certain amount of such hearing loss is frequently recovered in the subsequent days and weeks. The remaining hearing loss however is irreversible. ASNHL may
be accompanied by other disorders of the inner ear such as dizziness or tinnitus.
When ASNHL develops into permanent hearing loss, it may have chronically debilitating consequences.
Hearing loss may have serious impacts on professional and personal lives, e.g. through avoidance or with-
drawal from social situations, reduced alertness and increased risk to personal safety, impaired memory and
ability to learn new tasks, or reduced job performance and earning power. Unfortunately, there exists no
standard therapy with proven efficacy for ASNHL so far.
About AM-111
AM-111 is a cell-permeable peptide that selectively blocks JNK MAPK mediated apoptosis of stress injured
hair cells and neurons in the cochlea. Major cochlear stress incidents that may result in irreversible hearing
loss include exposure to excessive noise, disturbances of the blood supply, viral or bacterial infections, and
exposure to certain ototoxic substances. When administered within a therapeutic window after the incident,
AM-111 can effectively protect cochlear hair cells and neurons that would otherwise undergo apoptosis
and be lost forever. AM-111's otoprotective properties have been extensively tested and confirmed in vari-
ous animal models so far, including acute acoustic trauma, acute labyrinthitis, surgery trauma, aminoglyco-
side ototoxicity, semicircular canal injury in otitis media and cochlear ischemia. AM-111 has been granted
orphan drug status in both the European Union and the USA for the treatment of acute sensorineural hear-
ing loss. The active substance of AM-111 has been in-licensed by Auris Medical from Swiss biotechnology
company Xigen S.A.
About Auris Medical
Auris Medical is a Swiss biotechnology company developing specific pharmaceutical compounds for the
prevention or treatment of inner ear disorders, an area of great unmet medical need. Around the world,
many million people are suffering permanently from severe hearing loss and / or tinnitus, still lacking truly
effective and safe treatments for their disorders. Auris Medical is currently focusing on the development of
treatments for acute inner ear tinnitus (AM-101) and for acute sensorineural hearing loss (AM-111).
Dr. Thomas Meyer, Managing Director, telephone +41 61 201 13 50, firstname.lastname@example.com


text: Couple Gets Engaged at the Chrysler Display of the 2012 Chicago Auto Show February 15, 2012 06:17 PM Couple Gets Engaged at the Chrysler Display of the 2012 Chicago Auto Show FOR IMMEDIATE RELEASE (February 15, 2012): In front of a crowd of auto show goers in the Chrysler Group display of the 2012 Chicago Auto Show, Gill Klinger proposed to his girlfriend Jennifer Stevens. A Libertyville Auto City employee, Jennifer sells Chrysler, Jeep and Dodge products in metro-Chicago and is well known throughout the dealer group in northern Illinois. Popping the question next to a Chrysler 300 at the auto show was a fitting beginning for the couple who plan to wed at Walt Disney World later this year. For additional questions or information visit: http://media.chrysler.com Back to News


text:
Baker likes Hannahan at corner spots for now
PEORIA, Ariz. -- Through his first four games of spring, Jack Hannahan has been used either at third base or first base. Most of his experience in the Majors has been at the corner infield spots, but he has limited experience at shortstop and second base.
Reds manager Dusty Baker was asked if Hannahan might see time at second base. Baker already has several middle infielders vying for roster spots, including Jason Donald, Cesar Izturis and Emmanuel Burriss.
"Right now, it's so early. I've got to see those guys first," Baker said. "When we get later in spring, I might see him. For now, it's first and third, like I told him. We have to see them at their position before I start experimenting. We have 32 games to go."
Hannahan, who turns 33 on March 4, was signed as a free agent to a two-year, $4 million contract in December.


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
What are your thoughts on the proposed water and sewer rate increases in Rockwood?
I think the major concern here shouldn't be who raised the water rates, who told them to, or how long we got lower rates. The issue should be the management of the utilities. Rockwood employs almost twice as many employees for the water and sewer departments as neighboring cities per customer. The customer to employee ratio is critical in that a well organized utility can keep costs down and thus not require as much money to operate. Has it ever occoured to you that payroll and benefits for these departments far exceeds the necessity. Ther are people reaping salary and benefits that simply aren't required. These surely are difficult financial times, and I would hate to see these people lose their jobs, as many of them are friends and neighbors. If these departments were private businesses they would long since have perished. Lets not get excited about our water rates and become concerned that our city officials look into the management of these departments and cut costs in a professional business-like manner so that our rates don't have to be raised.
Is the sewer rate a percentage of the water rate?
The FIRST responsibility of the Water Board is to provide potable water to the citizens. My water smells bad and tastes bad. I understand the reasons for the rate increase, but I should at least be able to expect drinkable water for my money.
While I do not fully understand what has happened here, maybe I did not catch the article, or it was not clear... I don't know.
It sounds like a "regulatory body" has ruled that the rate is too low, and they are requiring it to be raised. Do I understand that part?
For everyone who is attacking on this issue, is the required rate higher than it would have been, had it been raised periodically through the years? If not, if it is only being raised to the appropriate rate, then rather than crucify the people in charge, maybe we should thank them.
They somehow kept the rate lower than it should have been for a few years. Let's see now, they kept the rate lower than it should have been, now it is being raised. If it is not being raised higher than it should be, then they saved us money for a few years, by keeping the rates low. Now we've been caught, and will be paying what the "regulatory body" considers to be the correct rate.
Norm in Rockwood
Incompetence comes to the front in my thoughts.
Where are the qualified individuals within the organization? How can a manager, as well as an oversight board, be so unaware of the regulatory requirements?
In the end, it's the consumer who pays for the incompetence, not the management. No different than TVA I guess...
Actually, for clarification, the sewer rate is in effect. The proposal is for the water rate. The water rate base rate increase is no more than $1.25 - 15%. Over the past decade when milk has gone up 100%, I don't think it's that big a deal. Lord knows I use a whole lot more water than milk. Although with the number of kids in my house gallon usage of milk versus water may be close.


text:
Exciting promotions and giveaways at Coors Field.
Ticket Packages include specially designed Rockies-themed college hats and Rockies themed MARVEL and Star Wars t-shirts.
Great benefits for Groups of 25 or more. Extra benefits for groups looking to fundraise.
2017 Ticket Specials are on sale now! Keep checking back for new offers.
Coors Field has many different types of Suites and Party Facilities to meet your needs.
Pregame picnic packages designed to fit any event and any budget.


text:
The Ultimate Color
In the foyer, the juxtaposition of an oversize honey-colored antique table and pale walls against dark bluestone floors has a quiet power. Douglass found the table, which often doubles as a buffet for the dining room beyond, in Belgium. Walls, molding, and ceiling are all in Benjamin Moore's Seapearl. The large antique concrete bowl and the hanging lantern are from Douglass's Atlanta store, South of Market.
In the gracious, pared-down living room, an unstained concrete fireplace surround highlights the golden patina of natural wood. White tufted chairs, creamy linen window treatments, and an abaca carpet present a neutral backdrop for red slipcovered wing chairs. A black Yuan Dynasty glazed urn and antique cutting boards are displayed in the simplest manner on a French console.
Where's the Chintz?


text:
Update: Criminal activity not a factor in Garrettsville fire
The cause of Saturday's fire that destroyed or displaced 13 businesses in downtown Garrettsville remains under investigation, officials said Sunday.
Read previous coverage: Blaze destroys businesses, history in downtown Garrettsville (with gallery and video)
At a press conference, Village Mayor Rick Patrick and Chief Dave Friess of the Garrettsville-Freedom-Nelson Fire District discussed what little is known about the blaze so far.
Garrettsville "is devastated by the happenings of the fire," Patrick said, while thanking the villagers, citizens and neighbors who have come together to support the emergency workers from the nearly 40 fire departments and police agencies that responded to what he said was the largest fire in village history.
"I just am overwhelmed," he said. "I've been trying to be strong. I want to be strong for Garrettsville. Garrettsville is strong, we will remain strong and we will rebuild."
Friess said the investigation, which could take "two to three weeks," will include insurance costs and inventory lost by those businesses. The State Fire Marshal's Office, ATF and the Portage County Fire Investigation Unit are all involved, he said.
"It's took soon to give a damage estimate," Friess said. "I couldn't even give you a ballpark (estimate)."
Firefighters were still on scene Sunday, dealing with hot spots. Friess said two firefighters, including one from his department, were treated for smoke inhalation, released from the hospital and are now recovering at home.
The fire initially was reported at 1:15 p.m. when "somebody ran into the (Garrettsville) police department and said the village was on fire," Friess said. No firefighters were on station in Garrettsville at the time -- the fire district is staffed Monday through Friday, with on-call staff available on weekends, he said.
Patrick estimated that 50 customers and employees were present in the affected businesses when the fire started -- including his wife, who was shopping at Shaker Tree at the time, he said.
He said the age of the buildings involved -- the Buckeye Building dates to 1850, he said -- along with the amount of times it was remodeled with double- and triple-roofs, open ceilings and spaces played a role in the speed with which the fire spread.
Friess said he couldn't comment on whether there was currently rehab work going on in the buildings or whether someone was doing work at the time. Where the fire started will also be part of the investigation.
"There was some type of roof collapse prior, during the snow and rain (this winter), but to my knowledge that was remedied temporarily," he said. "Our main concern was that everyone was out" along with the safety of firefighters and onlookers.
Fire departments from four counties eventually responded with personnel and equipment, including more than a dozen tanker trucks that trucked in water to support the village water system. Village residents and businesses may experience some low water pressure in the next few days, Friess said.
"Everybody was great. Everybody worked together well. We had great communications. Everyone had a task to do and they did that without any kind of complaining. It was awesome to have 34 (fire) departments here and everybody was able to work together. The camaraderie with everyone was great," he said.
Friess said he is "still taking it in. We still have a task to accomplish."
Garrettsville Police Chief Anthony Milicia said his agency was lucky as the nearby Hiram Police Department "immediately sent three officers, and then backed them up with a fourth" to help his officers with crowd and traffic control. Six Portage County sheriff's deputies, Portage County Sheriff David Doak and his command staff also lent help, including use of their mobile command center. Other officers helped cover regular patrol shifts and are maintaining security at the fire scene.
State routes 82 and 88 were closed with "minimal disruption" and officers helped re-route traffic around the village, Milicia said.
In downtown Garrettsville on Sunday, residents took stock of the aftermath, surveying the damages to the downtown business district.
Iva Walker, a retired social studies teacher, says that the law office of attorney Robert Mishler survived in part because it had a firewall installed in case the Buckeye Building caught fire. Emily Mason, whose mother works for attorney Kim Kohli, said they were trying to see what they could salvage from the law office.
The Nelson-Garrettsville Community Cupboard, a food pantry serving 80-plus families in the area, lost its office and all its food. Joe Leonard, a Nelson Township Trustee and co-founder of the Community Cupboard, said offers have come in for use of temporary facilities for the outreach program.
He said he hopes to have the food pantry up and running within a week.
"In a week or two, we'll be back on our feet again," Leonard said. "(The fire) is bringing the community together big time."
He said the community already has made substantial donations and that he has received multiple offers of help. Area churches are starting fund raisers, the James A. Garfield School District has offered assistance and the Center of Hope in Ravenna has offered to help the 80-plus families in need that were receiving support from the Nelson-Garrettsville Community Cupboard.
"We lost everything," Leonard says. "We looked in there today; nothing is recognizable."
Current needs include monetary donations, non-perishables, gloves and hats for kids, and paper products, he said.
"People are coming to our rescue from all over the place," Leonard said. "Community support has been absolutely beyond belief incredible."
Sky Plaza IGA owner Rich Hoffman says the Cub Scout Pack 62 will be at the store from 4 p.m. to 7 p.m. today collecting dry food donations and cash donations from the registers. Brownie Troop 91010 and the Girl Scouts will be at IGA Thursday and Friday from 4 p.m. to 6 p.m.
Hoffman says that they expect to continue the cash and dry food donations for weeks to come, and expressed "our thoughts and prayers" for those affected by the fire.
"We'll do what we can to help the community," he said. "We're hometown proud."
"Everybody pulls together," IGA office clerk Jamie Binegar said. "Seeing this stuff on Facebook was devastating."
Also on Sunday, several Portage County groups and agencies announced what they are doing to help out:
Donations to the victims of the fire may be made at Middlefield Bank on State Street in Garrettsville. The bank may be reached at 330-527-2121.
Monetary donations also can be mailed in care of the Nelson-Garrettsville Community Cupboard, P.O. Box 210 Garrettsville, OH 44231.
Non-perishable food items, household supplies, or monetary donations for the Nelson-Garrettsville Community Cupboard will be accepted at The Weekly Villager building, 8088 Main St. beginning at 9 a.m. today.
Donations also can made to the Garrettsville United Methodist Church, 8223 Park Ave. Office hours are Monday through Friday, 9 a.m. to 1 p.m., and the phone number is 330-527-2055.
The Mental Health & Recovery Board at 155 E. Main St. in Kent is a collection spot for nonperishable food items. Hours are Monday through Friday, 8:30 a.m. to 5 p.m.
More information on how you can help also is available at the Garrettsville Area Chamber of Commerce website at garrettsvillearea.com/how-can-i-help.html. Those wishing to help may also send an email to firstname.lastname@example.com.
A meeting to organize volunteer recovery efforts has been set at 7 p.m. today at James A. Garfield High School, 10233 S.R. 88, Garrettsville, in the commons area in the events entrance. Business owners have been invited to attend.
Contact O'Brien at 330-298-1128 or firstname.lastname@example.com and Woolf at 330-541-9448 or firstname.lastname@example.com
Facebook: Dave O'Brien, Record-Courier
Twitter: @RCCrimeWatch