text:
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
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This study will evaluate and treat children or adults with inherited or developmental eye conditions. It will allow specialists in pediatric ophthalmology, genetic ophthalmology, and ocular motility at the National Eye Institute (NEI) to learn more about the course of various pediatric, genetic, developmental, and eye movement diseases thorough long-term observation and treatment. It will also serve as the first step in determining the eligibility of patients who may wish to enroll in other NEI clinical research studies or undergo standard eye treatments.
Children with eye conditions, especially inherited or developmental conditions, and adults with eye disorders that began in childhood or that likely have a genetic or developmental component may be eligible for this study. Participants will undergo some or all of the following procedures:
- Medical history, including family history.
- Physical examination and possibly routine blood tests, x-rays tests, standard eye movement recordings, questionnaires, and specialized procedures when needed.
- Complete eye examination, including vision test, visual perception, eye pressure (if possible), dilation of the pupils to examine the back of the eye (lens, vitreous, and retina).
- Photographs of the eyes.
- Oculography (eye movement recordings) in patients for whom testing will aid in diagnosis. This test is done either with goggles placed over the eyes or with a contact lens placed on each eye. When the goggles or lenses are in place, the subject looks at a series of red targets on a computer screen.
- Electroretinography (ERG) in patients with suspected retinal degeneration. This is a test of the electrical function of the eyes. Before the test, patients sit in a dark room for 30 minutes with their eyes patched. A small electrode (silver disk) is taped to their forehead. The eye patches are then removed, the eyes are numbed with drops, and contact lenses are placed in the eyes. The contact lenses sense small electrical signals generated by the retina when lights flash. During the ERG recording, the patient looks inside a large empty bowl. A light flashes, first in the dark and then with a light turned on inside the bowl. The test takes 1 hour or less.
Participants are followed up to 6 times a year for 3 years, depending on the diagnosis and treatment.
|Eye Diseases
|Study Type:
|Official Title:
|Evaluation and Treatment of Pediatric, Developmental and Genetic Eye Diseases
|Estimated Enrollment:
|Study Start Date:
|January 14, 2004
|Estimated Study Completion Date:
|October 28, 2008
The purpose of this protocol is to allow the pediatric ophthalmology, genetic ophthalmology, and ocular motility specialists at the National Eye Institute to gain additional knowledge of the course of various pediatric, genetic, developmental and ocular motility diseases. Heretofore, this spectrum of diseases will be referred to as pediatric ophthalmology diseases. We wish to evaluate the effects of standard treatments for these diseases, use non- or minimally-invasive technologies to understand the pathogenesis of these diseases, and to collect blood or other easily obtained biologic sample (e.g., urine, saliva, hair, cheek swab, or stool) for future laboratory studies on these diseases. The information gained from this protocol will also allow for the maintenance of populations of patients with specific pediatric eye diseases and strabismus that may be eligible for future protocols. In addition, by allowing for the care of patients with a spectrum of these diseases, the protocol will be valuable for the training of pediatric eye disease, ocular genetics, and ocular motility fellows. The pediatric, genetic, and eye movement specialists at the National Eye Institute will choose ophthalmology diseases based on the training and research needs of the NEI program. While the primary focus of this protocol is to study eye disease in children, adults who have a disease that began in childhood or who may have an inherited eye disease or are unaffected first-degree relatives may also be evaluated under this protocol.
This protocol is not designed to test any new treatments. Any evaluation of treatments under this protocol will be based on the standard-of-care for each patient's disease. All alternatives for evaluation and care will be reviewed with each patient and the patient's family.
Patients in this evaluation and treatment protocol will be evaluated for potential eligibility in any new NEI clinical trials or epidemiological protocols as they are developed. If eligible, patients may be asked to participate in a new protocol. However, they will not be required to enter any new protocol and their decision to participate will be entirely voluntary.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Subjects will be able to enroll if they:
- Are a pediatric patient, of any age, with ophthalmic conditions, especially inherited or developmental conditions, OR
- Are an adult patient with an eye disorder that began in childhood or that is likely to have a genetic/developmental component, OR
- Are an unaffected first-degree relative that we believe that will aid in our diagnosis or future research objectives, AND
- Have the ability to understand and sign an informed consent OR have a legal parent/guardian with the ability to do the same.
Subjects will not be eligible if they:
- Are unable to follow-up as clinically indicated.
- Have a severe systemic disease that compromises our ability to provide adequate examination and/or treatment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00076271
|United States, Colorado
|Rocky Mountain Lions Eye Institute
|Denver, Colorado, United States
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00076271 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 16, 2004
|Last Updated:
|June 30, 2017
Keywords provided by National Institutes of Health Clinical Center (CC):
Cataract, Pediatric
Optic Nerve Anomaly
Evaluation and Treatment
Pediatric Ophthalmology
Genetic Eye Disease
Pediatric Eye Disease
Developmental Eye Condition
Juvenile Glaucoma
Eye Movement Disorder
Additional relevant MeSH terms:
Eye Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text: Hi friends. I am Josh, and I have been a practicing lay Theravadin for about two years now. I live in Houston, Texas. I am a single father and a part-time college student. Although I have occasionally visited the local vihāra here in Houston, I am not closely affiliated with it and am very happy to find a place to discuss the Dhamma with other practioners, especially in English! It seems that most of the teachers I read and follow are Sri Lankan or are affiliated with Sri Lankan Buddhism, such as Bhikkhu Bodhi, Narāda Thera, Bhante G, but I also enjoy Thanissro Bhikkhu's writings. I hope to have many fruitful Dhamma discussions!

subset: commoncrawl


text:
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Styx (pronounced "sticks") is an American rock band that was popular in the 1970s and 1980s, with such hits as "Come Sail Away", "Babe", "Lady", "Suite Madame Blue", "Mr. Roboto", and "Renegade." Styx is the first band to have 4 consecutive albums certified Multi-Platinum by the RIAA.With the intention to prove the flair and love for the rock music, the group was originally formed as "The Tradewinds" in the Chicago, Illinois, area in 1961 and played local bars while attending Chicago State University. This early line-up of the group included brothers Chuck Panozzo and John Panozzo on guitar and drums, respectively; and vocalist, pianist, keyboardist, and accordion player Dennis DeYoung. Changing their name briefly to "TW4", Chuck switched to bass guitar and the band added guitarists and vocalists James "J.Y." Young and John Curulewski.
The band members decided to choose a new name when they signed to Wooden Nickel Records; several suggestions were made and according to DeYoung, Styx was chosen because it was "the only one that none of us hated."
The band's Wooden Nickel recordings, Styx (1972), Styx II (1973), The Serpent Is Rising (also 1973) and Man of Miracles (1974), were a mixture of straight-ahead rock with some dramatic prog-rock flourishes and art-rock aspirations. The Serpent Is Rising would foreshadow later endeavors by the group-the so-called concept album would be a medium upon which Styx would rely heavily by the 1980s.
After producing several albums by 1980, Styx had established themselves with their lyrics, criticizing unemployment ("Blue Collar Man"), consumerism ("The Grand Illusion"), and materialism ("Pieces of Eight").In January 1981, Styx released Paradise Theatre, a loose concept album that became their biggest hit, reaching number one on the Billboard pop albums chart and yielding five singles, including the top ten hits "The Best of Times" by DeYoung (#3) and "Too Much Time on My Hands" by Shaw (#8).
The band was accused by a California religious group and later Tipper Gore's P.M.R.C of back masking satanic messages in their anti-cocaine anthem, "Snowblind." J.Y. has often gone on the record, refuting this charge during his concert introduction for "Snowblind," with Dennis saying on In the Studio with Redbeard which devoted an entire episode to the making of Paradise Theatre that "we had enough trouble to make the music sound right forward. It was the name Styx which is the river that runs through the underground. Can you imagine attacking the band that made Babe, I mean please!"
Owing to its accessibility and quality production, this album helped win the band a People's Choice Award in 1981, and became the band's fourth consecutive multi-platinum album. Throughout the 1980s, the band has used the album's opening track, "Rockin' the Paradise," which hit number six on the rock charts in 1981, to open their shows. The album closes with J.Y.'s "Half-Penny, Two Penny" which segued into Dennis' "A.D. 1958" and ending properly with "State Street Sadie".Dennis DeYoung and Tommy Shaw released a string of solo albums, beginning with DeYoung's Desert Moon and Shaw's Girls with Guns in 1984. Both Shaw and DeYoung generated a moderate amount of interest with their first solo albums. DeYoung, in particular, scored a Top 10 hit with the title track, "Desert Moon", which was also heavily featured on MTV.
Shaw also cracked the Top Forty with "Girls with Guns" and "Lonely School," and he made a cameo appearance on the NBC television series, Miami Vice. DeYoung's follow up single "Don't Wait for Heroes" also featured a video that was heavily featured on MTV, but it failed to generate significant airplay at radio only peaking at #83. During the filming of the video, DeYoung injured his back, causing him to back out of opening a North American concert tour for Huey Lewis & the News.
As of April 21, 2006, according to the RIAA (Recording Industry Association of America) which awards artists and groups gold as well as platinum status primarily on their performance and popularity, Styx ranks number 127 with 17.5 million records sold within the United States. On April 16, 2007, Def Leppard announced a 50-date concert tour, which will include Styx and Foreigner as opening acts on some shows. As of August 27, 2007 Dennis Deyoung's single "100 Years From Now" is Number 1 on Quebec's Top 100.
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text:
Topic: Friend with CC - some good news
I've posted on this extremely helpful and supportive discussion board before for advice regarding my 58 year old friend who was diagnosed with a klatskin tumor approximately 4 x 5 cm in April 2012.
He was deemed unresctable, and turned down for LT. Starting Aug, he was undergoing a low dose chemo at Moffitt cancer center in Tampa (gemzar 600 - 800 mg). In the meantime they were in touch with other centers, and also Dr. Sonnenday (thanks to folks on the board for introducing us to him).
He had a follow up CT on Oct 15, and while the doctors at Moffitt cancer center deemed no change and wanted to continue chemo, the doctors at MD Anderson in Orlando indicated that they had seen the good side of his liver - the left side - had grown to the size of the tumor afflicted right side. They felt they would be able to resect the right side, and reconnect the left side to the small intestine. Dr. Sonnenday independently seconded the opinion of the doctors at MD Anderson.
The good news is that everything went as planned. My friend had a successful ten hour surgery this month (they also removed his gall bladder because of gall stones), and is now back home recovering well, stent free and bile drain free. He only has one drain in the stomach for now.
Of course, it's fingers crossed going forward but at least he's in partial remission for now. I wanted to share this good news with the wonderful people on this forum. One never knows when there can be something around the corner. I guess we've to just stay hopeful and try what we can, in terms of second and third opinions, reading up on treatments, asking questions and staying healthy.
A very happy new year to all of you.
Warm regards


text:
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text:
MARK Collier believes six points out of a possible nine represents a satisfying start to Chippenham Town's Southern League Premier Division campaign.
The Bluebirds got their home programme under way – following back-to-back away fixtures to start the season – with a 3-0 success against Arlesey Town at Hardenhuish Park on Saturday.
Former Swindon Town midfielder Alex Ferguson fired home the opener on 28 minutes and the home side were fully in command a minute before the break as skipper Alan Griffin – playing for the first time this season after a groin injury – fired home the second.
Zac Evans hit the crossbar from long range in the second period but the points were wrapped up as Luke Ballinger fired home a free kick late on.
Collier said: "It was a good win and I thought we played particularly well in the first half. The job was done then, to be honest – we scored two decent goals and we saw it out quite comfortably.
"(I was pleased) with the way we started. We got on the front foot early and had a couple of early chances. We kept the ball quite well and out movement was good going forward.
"It's good considering we are still three of four short and having had two away games to start with.
The Bluebirds travel to Dorchester Town on Tuesday night with wing James Guthrie poised to return after serving a suspension and striker Lee Phillips, who also missed out on Saturday, also in contention.
Bryan Smith and Ellis Dunton remain on the casualty list, while Ferguson will be monitored after receiving a dead leg at the weekend as will Griffin, who was sore after his first match back.
Collier added: "Dorchester is a good place to go and play. They've been relegated from Conference South so I'm sure they will be determined to get back to where they think they belong.''


text:
Internal investigators at the Environmental Protection Agency say the agency failed to follow peer-review guidelines when developing a key scientific document that underpins its greenhouse gas regulations.
The findings are likely to stoke Republican opposition to EPA's efforts to regulate greenhouse gases and could arm industry groups that are fighting the regulations in court. One prominent Republican is already calling for congressional hearings on the issue.
The document in question was developed by EPA and used to support its 2009 "endangerment finding." That finding concluded that greenhouse gases--including carbon dioxide, methane and nitrous oxide--pose a threat to public health. It paved the way for the EPA to begin developing greenhouse gas standards for refiners, power plants and other large emitters.
In a report released Wednesday, EPA's inspector general says the agency didn't follow federal guidelines for peer review when developing a 200-page scientific document to support its findings.
The impact of the inspector general's report on EPA's ability to develop new greenhouse gas rules, or to enforce existing rules, is unclear. Sen. James Inhofe (R., Okla.), a climate-change skeptic and the ranking Republican on the Senate's environment committee, is already calling for a congressional hearing to examine the findings.
The inspector general's report "confirms that the endangerment finding, the very foundation of President Obama's job-destroying regulatory agenda, was rushed, biased and flawed," Inhofe said in a statement.
The inspector general didn't evaluate the quality of EPA's science. It only reviewed the process the agency used for developing it. The inspector general noted that the National Research Council, one of the agencies that supplied EPA with scientific data, recently concluded that "climate change is occurring, is caused largely by human activities, and poses significant risks for a broad range of human and natural systems."


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The saga of Jerome Block, Jr.—from election violations to drug addiction, with chimichangas and Gatorade in between—captured Santa Fe's attention earlier this year. On election day, voters will have the opportunity to approve three amendments to significantly alter the face of the embattled Public Regulation Commission, to which Block was first elected in 2008. But current commissioner Doug Howe says the changes are much bigger than Block.
"Jerome Block, Jr. was useful in getting people's attention on this…but, for the most part, this is not a Jerome Block fix," Howe says.
Scandals aside, the PRC cuts a low profile, but it plays a pivotal role in most New Meixcans' lives. Five elected commissioners oversee the body, which approves gas, electricity, water, phone service and health insurance prices. (This chart shows several of the PRC's key functions, and how they'll change if the three PRC-related amendments are approved.) Although the PRC requires them to make important and complex decisions, commissioners themselves must simply be 18 years old, live in New Mexico for at least one year and not be convicted felons.
Amendment 2 seeks to change that by allowing the state Legislature to impose additional requirements—such as a college degree or related work experience—and calls for continuing education for commissioners.
Amendment 3 simplifies the PRC's mandate by moving its corporation-related duties to the New Mexico Secretary of State's office, which already has some corporations-related duties of its own. This would simplify matters for corporations—they'd only have to visit one office—as well as PRC staff and commissioners.
But commissioner Jason Marks says the most significant change comes in Amendment 4, which moves insurance regulation out of the PRC and makes it a stand-alone agency.
"Virtually no other state does it like us—mixes insurance and utilities," Marks tells SFR. The change will allow for more accountability and less political influence, he says, by establishing an independent nominating committee to select the insurance superintendent.
"This model would depoliticize hiring completely," Marks says. "This whole package is about competence. It's not going to make the PRC [perfect], but it's going to make the PRC better."


text:
Police are appealing for witnesses after a burglary in Winchester.
Two laptops were stolen from a house in Vale Road, Highcliffe, on Friday, August 22 between 9:20am and 10pm.
Police believe entry was gained via an unlocked door.
Anyone with information is asked to call 101 or Crimestoppers on 0800 555 111.


text:
The Good Jobs Challenge
Aug 31, 2012
Every month when the unemployment figures are released, journalists, policymakers, and advocates alike eagerly check to see whether the number has moved up or down. But the unemployment rate is just one indicator of the strength of our labor market. As we celebrate Labor Day, we need to pay attention not just to the number of jobs, but to their quality.
A new report from the National Employment Law Project finds that, two years into the recovery, the majority of new jobs being added to the economy pay just $13.83 per hour or less. CLASP's working definition of job quality considers not just wages and earnings, but also benefits, job security, advancement opportunities, work schedule, health and safety, and fairness and worker voice. However, these factors tend to cluster, with low-paid jobs also less likely to offer benefits and flexibility.
Job quality was a problem even before the recession. Five Labor days ago we wrote that "too many people are stuck in bad jobs— jobs that pay poverty-level wages and offer no benefits, jobs with little opportunity for advancement, jobs in which workers don't know from week to week if they'll get enough hours to pay their bills, jobs that workers can lose for staying home with a sick child." Today that is still true — and a frightening number of workers can't even get bad jobs.
In the face of the deep recession, government programs made a huge difference in millions of lives. Programs like SNAP and unemployment insurance, which were beefed up with added federal resources, helped millions of low-wage and unemployed workers fill their grocery bags and pay their bills. Additional aid to state and local governments kept teachers and firefighters on the job, and prevented deep cuts to health care and child care programs. The TANF Emergency Fund supported subsidized jobs for over a quarter of a million workers.
But these Recovery Act provisions have mostly ended, and there is little enthusiasm in Washington DC for new large-scale government investments. Both parties talk about deficit reduction and the need to shrink government spending. As low-wage, low-quality jobs increase, we cannot assume that government programs will make up the difference. This means we will have to fight for a government that works for all — but we also need to figure out how to move to an economy that works for all.
Getting to this new economy will take a combination of approaches and many partners to get involved — legislators to fight for standards like an increased minimum wage, or paid sick days; law enforcement to prosecute companies that steal wages from their workers or take deadly shortcuts; business schools that share the lessons from firms that succeed by investing in their workers; and informed consumers using the power of their wallets to vote for companies that support communities. Improving job quality won't be easy, but we can't ignore the challenge.


text:
Thieves have looted expensive Apple computers and iPads after breaking into at least eight Melbourne offices by prying concrete Telstra pit lids from the footpaths and hurling them through windows.
Detectives say the string of break-ins were all at offices in the City of Boroondara, in Melbourne's inner east, and spanned three weeks from March 28 to April 13.
Four offices on Canterbury Road in Surrey Hills were among those that were ransacked.
The thieves also targeted offices in Union Road in Surrey Hills, High Street in Kew, Shierlaw Avenue in Canterbury and Riversdale Road in Hawthorn.
''On each occasion, the offenders have used a Telstra pit lid to gain entry to the premises and once inside have stolen Apple electrical products,'' a police spokeswoman said.
Boroondara detectives will release CCTV images of two men they want to question over the commercial burglaries, which they say are linked.
One of the men is described as having a large build, a bald head and is possibly of Middle Eastern or Southern European descent.
The other man is described as tall with a slim build.


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Isn't this supposed to be the bright side thread? Hijacking it seems to be rather mean spirited.
A bird in the hand is worth two in the bush.
Or throw in a first-round pick and flip it for a max-level point guard...
the truth is there is no excuse... unfortunately, I don't think we know exactly what the solution is either-- maybe it's coaching but it could just as easily be that Danny is the glue holding it all together when he's healthy. Either way, this group has got to figure out how to get their act together and play some good basketball.
The thread asks for any bright sides us fans could think of. Some of you think there are and some don't. That's just the way it is. Those who don't think there are any bright sides don't mean to hijack the thread. They simply want to let other guys know what they think and how they feel. This is just basketball sure but like players, fans have different levels of intensity for the game. Like me, others are pretty pissed with how the team played thus far and they're pretty vocal about it. I know how they feel because I personally look to this team for inspiration and therapy from my stressful daily grind and seeing them lose to teams that are in deeper **** than us, well, you have no idea how badly I feel. No disrespect to each of you guys. Just a piece of thought from a fan who thinks the sky is falling.
Now on to the bright side cause I think these guys we have on the team are still likable for their different personalities:
1. Season is still early, and they may be able to get out of their funk and be actually cohesive and efficient.
2. There are still great coaches out there available and Brian Shaw is still with us.
I think it's time to dust off this thread and look at the brightside of things.
1. The Pacers are still in 2nd place and a full game up on the Knicks.
2. It looks like Roy really did have a wrist injury (I blame Gangnam Style) to begin the season and his production is more on par with what it was last season.
3. The schedule the rest of the season isn't too tough.
4. There's still time to sign one of the standout wing players from China (McGrady or Gary Forbes please!) if Granger won't be able to play the rest of the season.
5. The Pacers get to play Cleveland without Kyrie tonight!
I seem to be the only one not panicking.
Heres a fact. The only team in the east that has a winning record vs 500 teams is the Heat.
There is no NBA player named Monte Ellis.
Pacers are still a top-10 team in THE ENTIRE LEAGUE (Record-wise).
Hibbert has been scoring efficiently, more, and still defending at an elite level.
There hasn't been a huge slump for any of our starters (Not palying great, but no-one has fallen off the face of the earth)
The Pacers are 3 victories away from CLINCHMAS! (Yeah, the Pacers are about to be the second team in the East to clinch, just 3 years after ending a playoff appearance drought)
Only thing I'm not in agreement with you on is the signing a wing thing. Can't play in the playoffs, so it doesn't make sense to bring anyone in for the last few regular season games.
Since I'm looking at the brightside of things, I have to point out that Gerald Green looked really good against the Cavs again last night. Maybe he'll wake up from his funk and be the spark he was brought in to be.


text:
WAYNE, N.J. — Toys"R"U opened its first stores in Beijing this weekend, marking its continued expansion across China.
The opening of the Beijing stores marks the retailers debut in Northern China. Two additional locations are slated to open in September in Tianjing Galaxy Mall in Northern China and Nanning Mixc in Southern China. These four new locations add to the company's already robust presence in the country, including stores in Guangzhou, Shanghai and Shenzhen. By the end of September, the retailer will operate 30 stores across 21 cities throughout China.
"As a company, international expansion is a key part of our overall strategy, and we are committed to further growth and investment in our business in China," said Jerry Storch, chairman and CEO, Toys"R"Us Inc. "Our expansion into Beijing is an important next step as we aggressively extend the Toys"R"Us brand throughout Asia."
Last October, Toys"R"Us, Inc. acquired the majority stake in its business in Greater China and Southeast Asia from Li & Fung Retailing. With this agreement, the existing Toys"R"Us licensed operations in this region became 70 percent majority owned and controlled by Toys"R"Us, Inc. and 30 percent owned by Li & Fung Retailing.
Since that time, the company has continued to expand across the region, opening 10 new stores across Brunei, China, Hong Kong, Malaysia, Singapore, Taiwan and Thailand. In total, the company now operates more than 100 locations in Southeast Asia and Greater China. In addition, 14 stores in the Philippines and Macau continue to be operated under a license agreement.
Toys"R"Us, Inc. opened its first international locations in 1984 with wholly owned stores in Canada and a licensed store in Singapore and has continued to grow its operations around the world.
Toys'R'Us continues to expand in China
WAYNE, N.J. — Toys"R"U opened its first stores in Beijing this weekend, marking its continued expansion across China.


text:
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Clinical Utility Of Genetic Screening For HLA-B*5701, On Susceptibility To Abacavir Hypersensitivity
This study has been completed.
Information provided by:
ClinicalTrials.gov Identifier:
First received: June 19, 2006
Last updated: January 21, 2010
Last verified: January 2010
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- How to Read a Study Record
Study to evaluate the utility of prospective HLA-B*5701 screening on the incidence of abacavir hypersensitivity (ABC HSR) in 1800 previously ABC-naive adults with HIV-1 from Europe, Australia and other countries as applicable. The study has two (co-primary) objectives: i) to determine if screening for HLA-B*5701 prior to ABC-containing HAART results in a lower incidence of clinically-suspected HSR versus current standard of care (no genetic screening) and ii) to determine if screening for HLA-B*5701 prior to ABC-containing HAART, results in a significantly lower incidence of immunologically-confirmed HSR versus current standard of care (no genetic screening or patch testing). The study consists of up to a 28-day screening period, a randomised observation period (Day 1 through Week 6) and, for subjects experiencing a suspected ABC HSR and a subset of ABC-tolerant subjects, an epicutaneous patch test (EPT) assessment period. Eligible subjects will be randomised to one of two study arms: a Current Standard of Care Arm (no prospective genetic screening: Control) and a Genetic Screening Arm (prospective genetic screening). Subjects identified as HLA-B*5701 positive in the prospective Genetic Screening Arm will not receive ABC and will be excluded from further study. Subjects who experience suspected ABC HSR during the 6-week observation will be withdrawn from ABC-containing product and undergo EPT patch testing 6 weeks later.
|HIV Infection
|Drug: Abacavir
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase IV, Randomised, Multicentre, Double-blind, Study to Evaluate the Clinical Utility of Prospective Genetic Screening (HLA-B*5701) for Susceptibility to Abacavir Hypersensitivity
Resource links provided by NLM:
MedlinePlus related topics: Allergy HIV/AIDS
Drug Information available for: Abacavir Abacavir sulfateU.S. FDA Resources
Further study details as provided by GlaxoSmithKline:
Primary Outcome Measures:
- Incidence of clinically-suspected ABC HSR during the 6-week observation period. Incidence of immunologically-confirmed ABC HSR. The clinical diagnosis of which occurs over the 6-week observation period.
Secondary Outcome Measures:
- Incidence of clinically-suspected ABC HSR in Caucasians and in different ethnic sub-groups. Sensitivity and specificity, positive and negative predictive value of genetic screening for HLA-B*5701 for susceptibility of HSR.
|Estimated Enrollment:
|Study Start Date:
|April 2006
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion criteria:
- Infected with documented HIV-1.
- Subjects are Abacavir-naive (subjects can be antiretroviral therapy (ART)-naive or experienced).
- All subjects must have a clinical need for treatment with Abacavir (ABC) or an ABC-containing product that precedes the decision to participate in the study.
- If subjects are therapy naive they must meet the criteria for commencing HAART according to local guidelines.
ABC and ABC-containing products are not recommended during pregnancy. A female is eligible to enter and participate in the study if she is of:
- Non-child-bearing potential: women who are surgically sterile or post-menopausal, the latter indicated by history of no menses for a minimum of 1 year from the date of the screening visit.
- Child-bearing potential: women who provide a negative pregnancy test (beta-human chorionic gonadotrophin; beta-HCG) at Screening and who agree to one of the following methods of contraception (any contraception method must be used consistently and correctly, i.e., in accordance with both the approved product label and the instructions of a physician, during the study period and through epicutaneous patch testing where appropriate):
- Complete abstinence from intercourse from 4 weeks prior to administration of the ABC-containing compound, throughout the study, and for at least 4 weeks after discontinuation of ABC or ABC-containing product.
- Double barrier method (e.g., male condom/spermicide, male condom/diaphragm, diaphragm/spermicide). Hormonal contraceptives will not be considered sufficient forms of contraception for this study.
- Any intrauterine device with published data showing that the expected failure rate is <1% per year.
- Sterilisation (male partner of female subject).
Exclusion criteria:
- Has previously received ABC-containing therapy.
- Satisfies any contraindications or restrictions to ABC therapy as listed in the product labels. Treatment with ABC must be in line with the recommendations of the product label.
- The subject or any of their healthcare providers is aware of the subjects HLA type.
- Has undergone an allogeneic bone marrow transplant.
- Has an active or acute CDC Clinical Category C event at screening. Treatment for the acute event must have been completed at least 30 days prior to Screening.
- Current severe illness, including liver and renal failure, major organ allograft, malignancy requiring parenteral chemotherapy that can not be discontinued for the duration of the trial, or any other conditions which, in the opinion of the Investigator, would make the patient unsuitable for the study.
- Any laboratory abnormality at Screening which, in the opinion of the Investigator, should preclude the subject's participation in the study.
- Pregnant women or women who are breastfeeding.
- Any immunisation within 30 days prior to Day 1.
- Subject is, in the opinion of the Investigator, unable to complete the 6 week Observation period and the EPT assessments as required.
- Subject requires treatment with radiation therapy or cytotoxic chemotherapeutic agents within 28 days prior to Screening, or has an anticipated need for these agents within the study period.
- Subject is enrolled in one or more investigational drug/vaccine protocols.
- In France, an eligible subject is neither affiliated with nor a beneficiary of a social security category.
- A subject will not be eligible for progression to Baseline (Day 1) if any of the following criteria apply:
- A positive result for HLA-B*5701 in those subjects randomised to the genetic screening arm.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00340080
Show 254 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00340080
Show 254 Study Locations
Sponsors and Collaborators
|Study Director:
|GSK Clinical Trials, MB BS MRCP FFPM
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by GlaxoSmithKline:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Mallal S, Phillips E, Carosi G, Molina JM, Workman C, Tomazic J, Jägel-Guedes E, Rugina S, Kozyrev O, Cid JF, Hay P, Nolan D, Hughes S, Hughes A, Ryan S, Fitch N, Thorborn D, Benbow A; PREDICT-1 Study Team. HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008 Feb 7;358(6):568-79. doi: 10.1056/NEJMoa0706135.
|Responsible Party:
|Study Director, GSK
|ClinicalTrials.gov Identifier:
|NCT00340080 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 19, 2006
|Last Updated:
|January 21, 2010
Keywords provided by GlaxoSmithKline:
Additional relevant MeSH terms:
HIV Infections
Disease Susceptibility
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Disease Attributes
Pathologic Processes
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
Do you want to actually look forward to Monday mornings?
You can at Workday! We embody the qualities of a great company, offer world-class products and services, listen to our employees, empower creativity and innovation, and celebrate a job well done. Itâs that simple, and has earned us the #1 ranking on two 2012 âBest Places to Workâ surveys (as voted by our own employees).
If you thrive in an fast-paced environment where you have the opportunity to create and deliver high-quality, professional training courses, Workday is looking for you! Workday's Education Services group is looking for professional Instructors who have experience that runs the entire gamut of education -- from course concept to development to delivery. The positions will support our Human Capital Management (HCM) application so you must also have a strong command of HCM concepts and processes. The ideal candidate will be able to teach the Workday HCM business application to diverse audiences, including customers, implementation consultants, partners, and application developers. You will have the ability to define the course requirements, create the course deliverables, and see the work through, including delivery of the course. In addition, a proven ability to independently manage projects is highly desirable. This position requires the ability to collaborate with Content Development to repurpose the content created, Development and Product Management to ensure accuracy of course content and use of functionality, and Professional Services and Product Support for relevancy of course offerings. You should be passionate about the quality of what you do with an intense desire to continue to make everything you are involved in better. You should also be ready to work hard but have a lot of fun doing it!
This position can be based out of Chicago, Atlanta, or Pleasanton, CA.Â
|Atlanta, GA
United States
|Full Time
|Web Site:
|6230 Stoneridge Mall Rd.
Pleasanton, CA 94588
United States
Support Workday, Inc. with Social Media services
Find more Instructor, HCM (Services) jobs


text:
Washington County District Attorney, Oregon
The District Attorney's Office is responsible for the prosecution of individuals charged with crimes and other violations of state statutes that occur within Washington County. The District Attorney also provides legal assistance to the county's Juvenile Department, and prepares legal documents and performs trial work in delinquency and dependency proceedings. The District Attorney's Child Support Enforcement Program establishes paternity and monitors and enforces court-ordered child support judgments, actively pursuing delinquent non-custodial parents. The Washington County District Attorney's Office works collaboratively with all of the law enforcement agencies in Washington County as well as with the Community Corrections and Juvenile Departments. The District Attorney's Office is a member of the Local Public Safety Coordinating Council, the Governor's Sexual Assault Task Force, the Crime Victim Assistance Network of Oregon, the local Domestic Violence Intervention Council and leads the county's Major Crimes Team, Child Abuse and Elder Abuse Multidisciplinary Teams. Attorneys from the office also work closely with and assist members of interagency teams such as the Westside Interagency Narcotics team, the Fraud and Identity Theft Enforcement team, the Interagency Gang Enforcement Team, the Interagency Crimes Against Children team, the Crash Analysis and Reconstruction Team and the Metropolitan Gang Task Force.
In September and October, 2014, a Grand Jury convened to inspect the conditions and management at four correctional institutions in Washington County. Read the report of their findings.


text:
'There is a sense that the Sabres are supremely motivated by coming so close last season. They've dealt with the disappointment and taken the positive out of coming so close while battling so hard with a depleted lineup. No sour grapes. No woe is us. Just a reinforced, refocused collective belief that they are the team to beat.'
You are here: Home / SabresBeat / Looking sharp


text:
Eosinophilic Esophagitis Databank (CoFAR5)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Esophagitis Eosinophilic Esophagitis
|Study Type:
|Study Design:
|Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:
|Eosinophilic Esophagitis (EoE) Databank (CoFAR 5)
- Elucidate the genetic components of EoE, focusing on a candidate gene approach the TSLP/WDR36 locus and through GWAS analysis [ Time Frame: 48 months ]A Genome-Wide Association Study (GWAS) analysis of single-nucleotide polymorphisms (SNPs) from >1.5 million genetic markers will be conducted.
Biospecimen Retention: Samples With DNA
|Study Start Date:
|April 2011
|Study Completion Date:
|February 2016
|Primary Completion Date:
|February 2016 (Final data collection date for primary outcome measure)
Eosinophilic esophagitis (EoE) is a newly recognized chronic disease that is increasingly being diagnosed in children and adults. Many patients with EoE also have food allergies. EoE is characterized by inflammation and accumulation of a specific type of immune cell, called an eosinophil, in the esophagus. While there have been several large studies of EoE, very few have focused on the roles the immune system, genetics/heredity, and the environment in EoE.
The samples and information collected from participants will help to identify and understand the genetic mechanisms underlying eosinophilic esophagitis.
The Cincinnati Children's Hospital Medical Center will serve as the Central Laboratory for genetic characterization studies.
|Ages Eligible for Study:
|6 Months to 65 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Inclusion Criteria:
- Written informed consent/assent from participant and consent from parent/guardian for minors with agreement for genetic testing;
- Documented diagnosis of EoE at any time confirmed by study team (pathology report describing greater than or equal to 15 eosinophils/hpf in peak field of an esophageal biopsy. Participants with eosinophilia in extra-esophageal tissue are permitted).
Exclusion Criteria:
- Participants with known infectious causes of esophageal eosinophilia such as esophageal fungus, gastric H. pylori, or systemic parasites;
- Participants with a history of persistent eosinophilia greater than 1500 cells/mcl of blood.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01323803
|United States, Arkansas
|Arkansas Children's Hospital
|Little Rock, Arkansas, United States, 72202
|United States, Colorado
|National Jewish Health
|Denver, Colorado, United States, 80206
|United States, Maryland
|Johns Hopkins University
|Baltimore, Maryland, United States, 21287
|United States, New York
|Mount Sinai School of Medicine
|New York, New York, United States, 10029
|United States, North Carolina
|University of North Carolina
|Chapel Hill, North Carolina, United States, 27599
|Principal Investigator:
|Marc E. Rothenberg, M.D., Ph.D.
|Children's Hospital Medical Center, Cincinnati
|Principal Investigator:
|Mirna Chehade, MD, MPH
|Mt. Sinai School of Medicine
Additional Information:
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|NCT01323803 History of Changes
|Other Study ID Numbers:
DAIT CoFAR5
|Study First Received:
|March 24, 2011
|Last Updated:
|August 24, 2017
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
Eosinophilic Esophagitis
Additional relevant MeSH terms:
Eosinophilic Esophagitis
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Leukocyte Disorders
Hematologic Diseases
Hypersensitivity, Immediate
Immune System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
Michelle Badash, MS
A prostate biopsy is the removal of a small amount of tissue from the prostate gland. The tissue is examined to determine whether there is
A prostate biopsy is usually done after an abnormal finding by:
A prostate biopsy is the only way to find out if cancer cells are present.
Problems from the procedure may occur, but all procedures have some risk. Your doctor will review potential problems, like:
Factors that may increase the risk of complications include:
You may be asked to do the following:
The type of anesthesia depends on the method that your doctor uses:
Your doctor will use one of the following methods to do the biopsy:
About 30 minutes
You may have discomfort and soreness at the biopsy site. Pain and discomfort after the procedure can be managed with medications.
When you return home after the procedure, do the following to help ensure a smooth recovery:
After the sample is taken, it will be sent to a pathologist for examination under a microscope. This doctor will analyze the sample for cancer. If cancer is present, your doctor will work with you to develop a treatment plan.
It is important to monitor your recovery. Alert your doctor to any problems. If any of the following occur, call your doctor:
If you think you have an emergency, call for medical help right away.
National Cancer Institute
Urology Care Foundation
Health Canada
Prostate Cancer Canada
Causes, natural history and diagnosis of prostate cancer. Urology Care Foundation website. Available at:
http://www.urologyhealth.org/urologic-conditions/prostate-cancer/causes. Updated April 2014. Accessed September 25, 2014.
How is prostate cancer diagnosed? American Cancer Society website. Available at:
http://www.cancer.org/cancer/prostatecancer/detailedguide/prostate-cancer-diagnosis. Updated September 12, 2014. Accessed September 15, 2014.
Prostate biopsy. EBSCO DynaMed Plus website. Available at: http://www.dynamed.com/topics/dmp~AN~T905693/Prostate-biopsy. Updated March 25, 2016. Accessed October 10, 2016.
Rodriguez LV, Terris MK. Risks and complications of transrectal ultrasound guided prostate needle biopsy: a prospective study and review of the literature.
J Urol. 1998;160(6-I):2115-2120.
Tiong HY, Liew LC, Samuel M, Consigliere D, Esuvaranathan K. A meta-analysis of local anesthesia for transrectal ultrasound-guided biopsy of the prostate.
Prostate Cancer Prostatic Dis. 2007;10(2):127-136.
Understanding prostate changes: A health guide for men. National Cancer Institute, National Institutes of Health website. Available at:
http://www.cancer.gov/types/prostate/understanding-prostate-changes. Accessed September 25, 2014.
6/3/2011 DynaMed Plus Systematic Literature Surveillance
http://www.dynamed.com/topics/dmp~AN~T905693/Prostate-biopsy: Mills E, Eyawo O, Lockhart I, et al. Smoking cessation reduces postoperative complications: a systematic review and meta-analysis. Am J Med. 2011;124(2):144-154.
7/13/2016 DynaMed Plus Systematic Literature Surveillance
http://www.dynamed.com/topics/dmp~AN~T905693/Prostate-biopsy: Gershman B, Van Houten HK, et al. Impact of prostate-specific antigen (PSA) screening trials and revised PSA screening guidelines on rates of prostate biopsy and postbiopsy complications. Eur Urol. 2016 Mar 16.
Last reviewed September 2016 by Mohei Abouzied, MD, FACP
EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © EBSCO Information Services. All rights reserved.


text: Data is essential for improving outcomes for students. Whether it is informing improved instruction, empowering parents and communities, or helping policymakers make decisions and target resources, our education system needs data in order to continuously improve. In order to create a culture of trust that enables effective data use, policymakers and education professionals must ensure that the public has confidences that state and local leaders act to protect student data privacy. This self-paced course will discuss the value data brings to improve education, offer recommendations for addressing privacy concerns while promoting effective data use, and explore lessons learned from existing and emerging policies in education and other sectors.


text:
While thinking about what my new hunting purchases might be I wondered what order of importance hunters would place there hunting gear in. Assuming that weapons and ammo are at the top I will leave those off the list; however, I wanted to see how others would rank-order their equipment and what would be on the list. We each hunt in different areas and I assume the area will determine what is on the list and the order we put it in. I was thinking of keeping it to a top 10 list. Here is mine-I think:
1. Boots
2. Camo
3. Cover-up Scent
5. Water Purifier
6. Bino's
7. Knife
8. Sleeping bag
9. Tent
10. Spotting Scope
What is on your list?


text:
Topic: Depression After Surgery...And Do People Really Care??
Is this normal?
I'm home and healthy.
Things are good.
But now its like I feel like I need to start my life over. I feel like there is so much I need to do, but I don't know what to do.
And then...my family.
Can you believe NOBODY (other than my mom and dad) has called me in the past 2 months. No visits when I got home. Heck, I didn't even get a facebook message from some of them.
Any advice?
Wife to Brian; Mommy to Carter (11) and Madison (8)
Liver transplant 7-9-2013


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CHINO — Calvary Chapel Chino Valley, 12205 Pipeline Ave. will hold a free concert April 3 featuring The SkyPilot and a Gospel message for junior high through college-age young adults.
The free concert will be at 7 p.m. in the church chapel.
The SkyPilot, from Australia, recorded their first full-length debut album, "Lighthouse" and embarked on their first US tour in 2011.
Information: 909-464-8255 or calvaryccv.org


text:
Killin' It 031: Pornsaints at MOPIA
Aunia Kahn, Ellen Stagg, Francesco D'Isa, Giuseppe Petrilli,
Italia Ruotolo, Jeff Faerber, Katelan Foisy, Kris Wlodarski, Molly
Crabapple, Natalie Shau, Natsuki Otani, Pamela Tait, Robert Morris,
Steven Johnson Leyba, Yana Moskaluk, Zoe Lacchei and Zoë Corleone.
Opening: Friday the 23rd of July 2010 at 8 p.m. at Edi's Weinstube,
Stuessihofstatt 14 in Zurich.
Some of the artists will be present
Exhibition: 24.7.-19.8.2010 Mon.-Thu. from 11.00-24.00 hours, Fri. and
from 11.00-02.00 hours and Sun. from 14.00-22.00 hours.


text:
University Lecture Series: Mental Health Services
Dr. Paul Cotten, professor of psychology at William Carey University, will present a lecture titled, "Mental Health Services: From Institutional to Deinstitutional" on Thursday, February 28, from 3- 4 p.m. in the Lucile Parker Gallery. This lecture in one in the WCU's University Lecture Series. The public is invited to attend. Call 601-318-6170 for more information.
Event Date:
Thursday, February 28, 2013 - 3:00am


text:
Company awarded toy license for upcoming fantasy film...
For a great selection of film, comic and TV action figures and collectibles, check out BigBadToyStore.com, Urban-Collector.com, BriansToys.com, ClarkToys.com, ToyWiz.com, VNCToys.com, PastGenerationToys.com, MonkeyDepot.com, RPMDiecast.com, YesAnimation.com, and SuperheroToys.com.
For a great selection of film, TV and pop culture t-shirts and apparel, check out TShirtGurus.com and 80sTees.com.
Jazwares has been awarded the toy license for the upcoming feature film Percy Jackson & the Olympians: The Lightning Thief by Twentieth Century Fox Licensing & Merchandising (Fox Licensing). The Jazwares product line will include action figures and accessories inspired by the contemporary adventure-fantasy film, which arrives in theaters everywhere February 12, 2010.
The Jazwares line will include single 4-inch figures of Percy and Grover; 5-inch Medusa and Zeus; and 7-inch Hades. Also available will be a 2" two-pack assortment of figures, 24" Sword, and a light-up pen.
Based upon the first novel in author Rick Riordan's best-selling book series, Percy Jackson & the Olympians: The Lightning Thief is set in a modern world where the twelve gods of Mount Olympus (perched 600 stories above the planet on New York's landmark Empire State Building) are alive, Percy Jackson, the teenage son of Poseidon, is suspected by Zeus of stealing his lightning bolt, the universe's most powerful weapon. Percy must prove his innocence, save his mother, and avoid a devastating war among the gods.


text:
NEW YORK ( TheStreet) -- It's time for the Federal Reserve to do less to prop up the recovery and jobs creation. The economy suffers from too little demand. Simply, the huge trade deficit with China and on oil sends too many consumer dollars abroad that don't return to buy U.S. exports, goods and services. During the Bush years, Americans artificially boosted demand by spending more than they earned, borrowing recklessly against their homes, on credit cards and for college educations that proved poor to be investments. Ultimately, failing loans sank financial markets. Meanwhile, other problems festered. Health care costs and university tuition rocketed, longer life expectancies undermined Social Security, and states borrowed too much. When the president campaigned in 2008, he promised to get tough with China on trade and produce more oil. He has done little about the former, and in the wake of the Deepwater Horizon disaster, he punished an entire industry for BP's ( BP) sins by curbing drilling offshore and in Alaska. He dramatically increased federal spending on entitlements, made student loans even more accessible and eschewed the recommendations of the Simpson-Bowles Commission to raise the retirement age. With federal deficits exceeding $1 trillion for five years, Mr. Obama faces the same skeptical bond rating agencies that downgraded European government debt. The Congress shares blame in its unwilling to address honestly trade, energy, health care and education. The Federal Reserve became an enabler of Presidential and Congressional inaction by keeping interest rates artificially low for five years, and now by printing money to buy U.S. bonds and mortgage-backed securities at a $1 trillion annual pace. Record low interest rates are propping up weak consumer demand but sowing the seeds of another financial crisis. Easy money is again pushing to unsustainable prices for real estate in prime urban areas and boom towns, agricultural land and the bonds of weaker corporations. And cheap borrowing rates help banks push student debt to more than $1 trillion, even though one in six loans is in default, and permit California, Illinois and other states to avoid reforming pension systems and issue debt they never will repay.
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text:
Just too much comedic gold for me in this 30 second clip to just let slideThis quote is hidden because you are ignoring this member. Show Quote
- Just love how the BBC news anchor does this in his "matter of fact" way... "Children were just feeding the ravenous pelican..."
- Notice how the duck at the end chases the pelican off like, "Hey, you just ate my buddy. You *******!! Or better yet..."Hey asshat, We have rules against just eating other feathery friends and neighbors... Get the hell outta here!"
- Can't forget the cut away to the female Britt trying to keep a straight face... "That's terrible." Looks like she was as amused as I was.


text:
*I posted this in the "Simple Keys" thread origianlly, but I took the advice of iacas and posted it as a thread of its own*
I was thinking about a similar set of keys to the game but in a simpler way. At this point I'm just starting to understand and impliment the more specific, technical parts of form. I do realize that the nuances, technical aspects and physics of form are what ultimately let you attain the goals of driving 450'+ and being a consistent putter within so many feet of the basket and being accurate consistently. At the same time I'm wondering what the ends are that these means are trying to achieve, such as what is the workable distance of a successful, well-rounded disc golfer (all around, not just tournament play or casual rounds). I'm not necessarily talking about the extremes either. We all know about the freaks of the disc golf world who can hit ridiculous distances consistently and who never miss a putt, but what are the "simple keys" for a player that is consistently doing well? I'm getting at something like this:
-Consistent putter within __'
-Has a workable golf distance of ___'-___'
I know I'm leaving a lot out, but what should be added to this list of "simple keys" for a well-rounded, successful disc golfer?


text:
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If you receive a text message saying you "have been randomly selected for a $1000 Best Buy Card" or another text offering you a free Walmart gift card, delete the message! This is a smishing scam! Both text messages ask you to click on a link to claim your "prize."
Some BBB employees received the Best Buy text message last night.
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text:
Lefties haven't been getting job done in bullpen
SEATTLE -- Astros manager Bo Porter admitted Wednesday he's concerned about the inability of his left-handed relief pitchers to get outs.
Kevin Chapman began the season as the only lefty in the bullpen, but he was optioned to Triple-A Oklahoma City after allowing seven walks, five hits and five earned runs in 3 2/3 innings. Veteran Raul Valdes was called up and has given up three walks, two hits and three runs in two-thirds of an inning.
"When you have just one [lefty] down there, they're down there for that specific reason," Porter said. "You would like to be able to bring them in the game and know that they're going to throw strikes. Whether or not you get the guy out is the second part of it.
"There's no defense for walks. You don't even get a chance of defending the ball. That's more so been our problem in that lefty-lefty matchup situation, is we're walking them on base and giving up hits after that, which is definitely not good."
That being said, Porter said he feels comfortable using right-handers Chad Qualls and Matt Albers against lefties.
"That's why we felt comfortable with just having one [lefty in the bullpen]," Porter said. "With that being said, even the one you have down there, they have to be able to win that matchup, left on left."
Brian McTaggart is a reporter for MLB.com and writes an MLBlog, Tag's Lines. Follow @brianmctaggart on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Senso Diffusion is an Australian shoe brand that has grown far beyond homeland popularity to become embraced by an international following. These unique shoes have been catching the eyes of shoe lovers the world over. Senso Diffusion takes classic footwear and spices it up with updated essentials, refreshing takes on collection favorites, and a diehard commitment to amazing quality, comfort, and style. Senso's lovability is rooted in the brand's signature look.
No products match your selections. Try clearing your filters.


text:
This is perhaps a strange request and I do not mean to be disruptive. I did enjoy my time here and it was of great benefit to me. The request I make is one that is often made by contentious people who, in fits of impassioned emotion, only wish to cause further contention. My intent, however, is quite the opposite: I feel as though any posts that I made here only caused contention rather than reducing it.
The request is this: If it is possible, I would greatly appreciate it if you could delete my account and all of the posts made (including this one).
If they cannot be deleted, please at least hide them from view and do not make copies of them.
Sometime, in the distant future, people may read these posts or copies of them (or images) that are scattered throughout the internet. I ask that you disregard these posts or any scattered images throughout the internet, not delighting in them or obsessing over them. If you want something to obsess over, obsess over truthfulness.
What do I mean by truthfulness? I mean being honest with oneself with what one does. If one is honest, there is no regret; things are done automatically, life works like it's supposed to work. Inward honesty is proper meditation: You investigate inside and see what's there, what's not there, and there is no confusion about it. Outward honesty is proper mindfulness: You look outside and see what's there, what's not there, and again, there is no confusion.
Thank you all and god bless.


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July 16, 2013 — Coral Gables, FL — Celebrating its 30th Anniversary Season this October, the University of Miami Frost School of Music's Festival Miami is thrilled to announce that its acclaimed month-long music festival will open in grand style this year with seven-time Grammy Award-winning international superstar Gloria Estefan performing a unique jazz-influenced program on October 1, 2013 at 8:00 PM at UM's Maurice Gusman Concert Hall, 1314 Miller Drive on the Coral Gables campus.
The multi-media concert promises to be a memorable evening of music featuring the singer-songwriter-entrepreneur performing standards from the American Songbook that have special significance to Estefan and are featured on her upcoming album (to be released on September 10 by Sony International), The Standards, arranged, orchestrated and co-produced by Grammy-nominated jazz arranger and Dean of the Frost School of Music Shelly Berg. South Florida concert-goers will enjoy new renditions of timeless classics such as "Good Morning Heartache," "Embraceable You," "I've Grown Accustomed to His Face," "Smile," and "What a Wonderful World," plus Latin American love songs "El Dia Que Me Quieres" and "Eu Sei Que Vou Te Amar." The program will also feature behind-the-scenes video footage from the studio recording and highlights from the upcoming PBS Standards concert that Estefan recorded with the Frost School of Music's Henry Mancini Institute Orchestra, conducted by Shelly Berg, at the New World Center in Miami Beach. This concert is featured as part of the Festival Miami's Music of the Americas series.
"I grew up listening to Frank Sinatra, Johnny Mathis, Henry Mancini and great romance recording artists in Cuba," said Estefan. "This genre is right up my alley, since music is always a catharsis to me." She waited until now to do a standards album to get "enough life under my belt," she added, "since there are so many torch songs requiring life experience to deliver them with proper credibility." The concept really took off at a trustee dinner at the University of Miami's Frost School of Music, where Shelly Berg, who has produced and arranged for artists including Patti Austin, Elliot Smith and Arturo Sandoval, serves as dean.
"We sat at the piano just for fun and he asked me to sing a song" said Estefan. It was during this evening that she also sang "Good Morning Heartache," the Billie Holiday classic that is now featured on The Standards.
"This album brings everything full circle for me!" she said, adding that the tracks were all chosen "by my heart and what I feel." She brought a list of standards to Berg that "spoke to me personally and made me cry."
"From the first moment of going through songs with Gloria I got that goose bump feeling that told me this was going to be a very special and important recording," said Frost School of Music Dean Berg, who arranged, orchestrated and co-produced the album. "The artistry and heart that Gloria brings to The Standards will resonate with people across a spectrum of generations and cultures. With this recording she has given us a beautiful gift."
Festival Miami -- South Florida's premier live music festival—annually presents unique programming by a diverse blend of award-winning performers in a variety of genres who showcase their artistic prowess alongside astounding students and faculty artists from the Frost School of Music. More than 25 concerts and events are organized into four themes: Great Performances, Jazz and Beyond, Music of the Americas, and Creative American Music.
Concerts previously announced under the Music of the Americas banner include international salsa superstar Luis Enrique on October 12; Brazilian vocalist/guitarist Paulinho Garcia on October 17; the Costa Rica National Symphony Orchestra, under the baton of multi-Grammy winning conductor Jose Serebrier, on October 22 and 23; and Latin jazz icon Arturo Sandoval on October 26.
« Back to Frost News Releases Archive


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General Law Legal Counsel
The General Law Division provides legal advice and counseling to GSA employees in fiscal and administrative law, legislation, employment and labor, privacy rights, freedom of information and the Federal Advisory Committee Act. The General Law Division represents the agency in matters before the Merit Systems Protection Board, the Equal Employment Opportunity Commission, and the Federal Labor Relations Authority involving GSA's Central Office. Attorneys assist the Department of Justice and the U.S. Attorney's Office with claims filed in federal court. The General Law Division also provides legal support to independent boards, commissions, and agencies. The General Law Division is responsible for managing the agency's alternative dispute resolution (ADR) program.
The General Law Division's employment law group provides advice to GSA managers on employee discipline, union-management obligations, Title VII discrimination, and sexual harassment. The General Law Division strives to resolve labor relations and employment matters in an expeditious manner whenever possible.
The General Law Division's fiscal and administrative law group advises on authorities of the agency, fiscal policy, budget, debt collection, non-contract claims against the agency and interagency agreements.
In addition to the above responsibilities, the General Law Division also manages the agency's ethics program through its Ethics Law Staff. The Ethics Law Staff consists of three attorneys and one support staff. Its responsibilities include implementation of applicable ethics laws and regulations; establishment of uniform policies and procedures to resolve conflict of interest situations; implementation of uniform procedures and standards for review of financial disclosure reports; and implementation of GSA-wide ethics training program.


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If you've ever wondered what exactly sour cream is, here's the deal: it's regular dairy cream that's been "soured" with the addition of bacteria. When the bacteria meets the cream, fermentation occurs, and the cream thickens and gets that characteristic tang.
Sour cream doesn't necessary get a lot of love, but personally I can't imagine chili, nachos, or latkes without it. And that's just on the savory side—sour cream has the ability to make the crumb of baked goods exceptionally tender and give frosting and cheesecakes an important flavor boost.
So the question isn't if you should use it in dessert, it's what to with that half container you have leftover. From ice cream to muffins, here are some ideas.
Tea Time
Blackberry Sour Cream Bundt
Cinnamon Apple Sour Cream Cake with Spelt
Strawberry-Sour Cream Coffee Cake
Chocolate Chip Oatmeal Mini Muffins
Extra Crumb Coffee Cake
Gluten-Free Baked Chocolate Doughnuts
Blackberry Crumb Cake
Sour Cream Chocolate Cupcakes
Tender Citrus Sour Cream Cake
Fudgy Chocolate Pretzel Cake
Chocolate Decadence Cake
Blueberry Upsidedown Cake
Cool Treats
Apple, Browned Butter, & Sour Cream Ice Cream
Coeur à la Crème Fraîche
Mint Chocolate Chunk Cheesecake Bars
About the author: Carrie Vasios Mullins is the editor of Serious Eats: Sweets. She likes to peruse her large collection of cookbooks while eating jam from the jar. You can follow her on Twitter @carrievasios


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Nats skipper familiar with pitching woes
SAN FRANCISCO -- Washington Nationals manager Davey Johnson can relate to the struggles of San Francisco's starting rotation, having guided some talented staffs himself.
Johnson's 1986 New York Mets, who won the World Series along with a staggering 108 regular-season games, had three starters -- Ron Darling, Dwight Gooden and Bob Ojeda -- finish with ERAs under 2.84. Two years later, his rotation of Darling, Gooden, Ojeda, David Cone and Sid Fernandez posted ERAs ranging from 2.22 to 3.25.
They rarely slumped. But when they did, Johnson found that pitch sequence tended to be a shortcoming.
"Sometimes your pitchers get in a rut," Johnson said before Monday's Giants-Nationals series opener. "Sometimes when you have really good command with one pitch, you use that pitch to set up all your other pitches and everybody gets to know it. You have to be able to go back and forth on setting up pitches to get guys out."
Johnson added that video equipment has eliminated surprises.
"With high-tech today, there ain't no secrets," Johnson said. "Everybody's got a video and everybody studies it, and there's somebody counting and tracking [pitches]. It's the same with hitters. If they have a weakness, opposing pitchers know how to get right at it."
Chris Haft is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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Huntington Beach, Calif. Robert McKnight has resumed his role as president of Quiksilver, and will remain both chairman of the board and CEO.
McKnight will be responsible for directing the company's strategic and operational initiatives, including renewing its focus on its Quiksilver, Roxy and DC core apparel and footwear brands.
Bernard Mariette has resigned from his position as president and as a director of the company in order to pursue other interests, which may include attempting to acquire the Rossignol group.


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Crashing the Blog Cabin Master Suite
Our Bath Crashers episode premieres Monday night, but today we have a special treat: an exclusive vlog starring Bath Crashers host Matt Muenster and Blog Cabin 2012 show host Chris Grundy. See what they have to say about the experience of remodeling both the master bedroom and master bathroom.And if you haven't yet, please take some time to click through our before-and-after slideshow, artistic photos and candid, behind-the-scenes snaps from the episode shoots. Enjoy!


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Spring rains helped some key agricultural states loosen the drought's stranglehold, but with summer less than two months away, concern lingers.
The latest Drought Monitor report, released on Thursday, shows that 46.9 percent of the nation is in moderate or worse drought. This is slightly improved from last week's 47.3 percent.
In the Corn Belt, where drought has persisted extensively since last fall, a surge of wetter weather systems have helped alleviate some of the drought's pressure.
Nebraska, once cloaked with extensive drought, now shows signs of improving. Currently 77 percent is in extreme to exceptional drought, down considerably from 96 percent reported at the beginning of the year.
South Dakota has showed similar reprieve from the drought's grasp with 21 percent reported in extreme drought, down from 29 percent last week.
Not all states are as lucky. Some – like Oklahoma and Kansas – are states split by drought. In areas were conditions are improving, primarily in the eastern half of both states, the end to the drought could be near. But for those where little relief is seen, conditions only continue to worsen.
In Oklahoma, 31 percent is in extreme drought, with the majority of this intense drought located in western areas of the Sooner State.
Colorado and Texas will soon be dominated the headlines as the drought deepens. Further to the west drought is also becoming a bigger story. Click here to read more.


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Wacha not yet ready to begin throwing
ST. LOUIS -- An MRI of Michael Wacha's right shoulder on Monday showed healing, though not enough for the Cardinals to clear him to begin a throwing program.
General manager John Mozeliak said that although the organization is encouraged by Wacha's improvement after two weeks of rest and rehab, Wacha will remain on the same program for another 14 days before being re-evaluated. The Cardinals have all along been hesitant to project a return date for Wacha because of how little they knew about the injury, termed a stress reaction.
"Obviously, the best news would have been that he had been cleared to throw," Mozeliak said. "He's not there yet, and I think, just taking a very proactive stance on this, this is best for him and his career. I'm sure he's frustrated and would like to be a little bit ahead of this, but I think this is just in the best interest of him. Hopefully, by the next time we do another MRI, he'll be clear."
The Cardinals have spent the past few weeks gathering more information about the injury, the root cause and treatment options. Mozeliak said the injury does not appear to be related to Wacha's mechanics but instead is a biomechanical issue that can be aided with strength work.
Monday's update comes a little more than three weeks before the non-waiver Trade Deadline, with the Cardinals still determining what needs they may address, but Mozeliak downplayed the correlation between Wacha's status and the organization's interest in acquiring another starter.
"Well, we expect to get [Joe] Kelly back ... and feel pretty confident that [the five in our rotation] can be successful," Mozeliak said. "There are probably very few pitchers we could go out and acquire without having to give up one of those to begin with. I think that would just make it problematic, so for us, we feel pretty good where we're at from a pitching standpoint."
Speaking more generally about the Trade Deadline, Mozeliak said, "I think you could say we could worry about a lot of things. The right strategy is, if we think there's an opportunity to improve, we'll try. We're not going to make a bad decision just in a panic situation."
Jenifer Langosch is a reporter for MLB.com. Read her blog, By Gosh, It's Langosch, and follow her on Twitter @LangoschMLB. Alex Halsted is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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han wrote:I am talking about entity interference/attachment and or influence/possession.
Just wondering if anyone knew of such things or had experience witnessing it or otherwise.
What does working with internal energies mean? I am not familiar with this.
The only entities I had interference with were aversion, craving, and ignorance regarding self.


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$70 for a Five-Hour CPR/AED/First-Aid Class ($140 Value)
The Heartsaver CPR/AED/first-aid class is designed for members of the general public, from fitness instructors and maritime personnel to nannies and babysitters—anyone with an interest in learning basic resuscitation for adults, children, and infants. Students learn essential life-saving techniques: how to operate an automated external defibrillator (AED), how to employ proper CPR technique, and how to use an EpiPen. They also learn to treat bleeding, choking, seizures, broken bones, snake bites, poisoning, and other life-threatening emergencies.<p>
Upon completing the course, students receive an official American Heart Association certification card that's valid for two years. Class times and offerings vary by location; schedules are available on each location's website:
Safety Training Seminars
An official American Heart Association CPR training center, Safety Training Seminars has provided first-aid education in life-saving courses since 1989. Although the center's American Heart Association instructors possess extensive life-saving skills, they still know how to present their material for the general public. Despite the urgent nature of the techniques they teach, they manage to create a low-stress and casual environment. Catering to those with busy schedules, classes are scheduled year-round across the Bay Area, with many times and locations available.


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Social Media Guidelines
General Guidelines for Official University Pages
Be concise
- Social networking sites aren't the place for novels. Make what you have to say "short, sweet, and to the point."
Be respectful
- When posting to any social media outlet in an official Radford University capacity, you should exercise respect for others' thoughts, opinions, ideas, and points of view at all times.
- Remember, anyone and everyone can see these posts. Make sure whatever is written reflects the proper image for Radford University to all audiences.
Be timely
- The purpose of social media is to be immediate. If you decide to launch a social media account for your department or college, you must also be willing to update it frequently with the most current information. If you have questions, please contact us to discuss best practices, email firstname.lastname@example.com.
Be relevant
- Make sure what you are sharing is of interest to your audience. It is not helpful if you are sharing information on the latest basketball schedule in a group devoted to soccer.
Be responsive
- Posting information is just half the battle in social media. You must also be monitoring feedback to the information you provide and should respond accordingly.
- Social media isn't, however, a place for heated, public debate. If you receive feedback you believe warrants an in depth conversation, suggest to that individual you talk privately via email or over the phone.
- While social media is meant to be a conversation where all respectful feedback is received and welcomed, you should delete overtly malicious or profane comments. If the problem persists, report the user to the program's administrator.
Be accurate
- Do not post something you do not know is factually accurate. Double check your sources and ask questions if you aren't certain.
- If something inaccurate is posted, correct your mistake as soon as possible.
Be accountable
- You and/or the university could be held accountable for what is posted online. Do not post anything erroneous, anything that could be considered a copyright infringement, or anything illegal.
- It is always a good idea to have more than one administrator on a social media account.
Be confidential
- Do not share anything online that could be in contradiction to FERPA laws or that could be considered proprietary information.
Be linked
- Provide links back to the university's web pages and news stories. This helps further tell our story.
Be "real"
- Finally, "talk" online as you would in a real life conversation. You're a real person and so are the people reading what you write.
Be connected
- Let us know about your social media site so it can be added to the Radford University Social Media Directory.
Questions? Email firstname.lastname@example.com.
General Guidelines for Personal Social Media Accounts
Be responsible
- There is truly no such thing as "private" in social media. No matter what your privacy settings are, your picture, comment, or note is only a copy and paste away from being shared with everyone in cyberspace. In general, if you wouldn't want your mom or your boss to see it, read it, or watch it, don't post it.
Be clear
- If you maintain a personal social media account, feel free to share your affiliation with Radford University. However, be clear the ideas expressed belong to you and not RU.
Be mindful
- To avoid the misconception of official endorsement, Radford University logos should not be used as profile pictures or icons on personal social media pages.
Be careful
- Do not reveal anything online that would allow others to easily find you or put you at risk for identity theft. For more on online safety, visit OnGuard Online.
Questions? Email firstname.lastname@example.com.