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Video Reviews
Hey this is Reuben with Competition Accessories and we just wanted to make a quick video on how you change the face shield out on the Arai helmet. A lot of people get intimidated by Arai helmet face shields because of the side pod they have where you cant see whats going behind it. What we have done on this helmet here is we installed a clear pod so we could give you a better look at the inner workings of the base plate mechanism and show you how it works. Basically to remove the face shield what I want you to see is this little gray lever here, there are one of those on each side of the helmet. When you raise your shield to the top position those will pop out. Now if your helmet is a little older or a little worn out they might not pop all the way out like a brand new helmet. With the face shield all the way up you just need to lift those levers all the way up. Once you have lifted those until they click, to take the shield off is very simple, you are just going to grab it from the top , rotate it back and pull it off. It comes right off really quickly. You will see guys out at the track if you watch racing at all like the isle of man for instance, they will pull into the pits and they swap face shields on or off in just a matter of seconds. It is one of those things you have to get the hang of. To reinstall the shield is a little trickier, there is a horse shoe shape cut out on the end of the shield here, that's going to line up with the top curve on the helmet or the pod and with the clear ones you can see the round tab that its going to slide over. Your going to slide that in on both sides and its not going to really click or anything, you just have to get it down and on to there like that. Once its in I find it easier to have the helmet facing away from you and then you are just going to close the shield. When you close the shield what happens is this opening this cut out right here slides over that little notch right there, so that is what limits the shield as It opens. That's how to change the Arai face shield out, hopefully that helps you out. You can go to our youtube channel if you click on this link in the upper right hand corner and subscribe to us. We have a lot detailed videos on helmets and other products. You can also check us out on facebook and check us out online, see you next time.
Hey guys this is Reuben with Competition Accessories and we have the all new Arai Signet Q helmet . The Signet was a very popular helmet for Arai they are bringing it back and replacing the profile in their line up , and what they've done is they have based the Signet Q off of the RXQ which is an intermediate helmet from Arai externally they look almost identical what they've done is they actually have elongated the Signet Q about 5 millimeters front to back its just going to be 5 millimeters longer and internally that internal shape is going to be a long oval. Arai has also done some pretty innovative things as far as customizing the fit of the helmet ill show you once we get into the interior what they've done some really neat features that really eliminate hot spots and that will allow you to have a very comfortable snug fit .Externally though again this is the RXQ this is the Signet Q, they look just about identical. Your going to have top vents that is going to open and close with rocker switches your going to have side exhaust cowls so as air flows over the helmet its going to draw warm air out the back and again out of the rear spoiler you have an open and close able vent that's going to draw warm air out the top , you also have a chin bar vent which is two position you can open it half way or all the way that's going to direct air onto the face shield just give you some extra air inside and lastly , and this is an Arai exclusive, they have vents actually built into the shield that direct air into the helmet and they have wind tunnels inside that direct air around on the side of your temples and your temporal artery is right at the side of your head and that really keeps you cool. You can see if i open the shield the little air ducts that directs air along the sides of your temples. One thing you may notice about the shield and well get into it once i take it off and ill show you exactly what it comes with but it actually has a reaccessed cavity built into the shield itself for a pin lock insert and the pin lock is actually included . Now if your comparing this to the Profile you may notice this is actually a wider eye port its 10 millimeters wider its the new SAI max shield which is the same as the RXQ so you just have a little better peripheral vision out of this helmet . As far as moving this shield its very simple a lot of people get a bit intimidated with Arai because it has side covers you cant really see whats going on but they are very easy to change. Basically once you open the shield all the way your going to see these two little trigger arms pop out there's a small little arrow on it basically what you do is pull it all the way up and its going to click on both sides, once you've pulled it up like that its ready to take off then all you do is grab the front of the shield and literally pull up and off . Again that's something that makes some people a little bit nervous but its very easy to do . I'm going to grab that pin lock insert if you've used a pin lock before you know it can be pretty challenging to get them in and out . Traditionally a pin lock shield has notches on either end of the insert which lines up with posts that correspond on the shield well Arai has done it a little bit differently. What they've done is they have actually molded a recess into the shield itself that this pin lock actually sits down into , and as far as installing it its a lot easier basically your just going to line up one end of the pin lock and then if you just push it down its just going to click right into place , that's so much easier then traditional pin lock systems. Id love to see other manufactures kind of follow in their foot steps because that's a lot more user friendly and a lot easier to change out as well. Obviously pin lock is going to basically make it duel layer lenses and what that does for you is number one that makes it a very very effective anti fog system if your riding in the colder environment or if its raining this pin lock is going to prevent fogging its also available with different color inserts in different tints so if you need a smoke insert you could do that and obviously other shields from the SAI max line up are going to fit on this helmet as well. To reinstall the SAI shield again this is something that may be intimidating some people because you cant really see whats going on here but basically your just going to take this notch line it up with the top part of this pod here and then you just insert it there kind of feel it click into place, Do the same for the other side. Once you have it in place like that basically your just going to close it and that's what actually is going to lock it into place. A little bit tricky to do it the first time once you've got the hang of it its actually pretty easy and a pretty nice system to swap out. Alright moving to interior of the Signet-Q Arai uses their dry cool fabric that is moisture wicking it keeps you very comfortable very dry it also pulls moisture away from your skin to keep you comfortable on warm days . You'll also notice there's a full neck roll on this helmet and what that does is a couple of things, One its just comfortable against your skin and Two maybe more importantly it prevents wind from entering the seams between the crack between the crown liner and the cheek pads , it just gives you a nice flush surface for the wind to travel over which significantly reduces wind noise as your riding . Another thing you might see here is these orange tabs those are notes to emergency personnel , if you have an accident and they need to remove your helmet basically what their going to do is pull on these tabs and that's going to reveal an orange pull tab right here and the cheek pads come right out its very simple, there's actually no snaps on these cheek pads its basically just have a notch on the front and back that kind of seat inside the helmet . You could also remove the entire neck roll. So that comes out and then as far as the lining there's two snaps at the back and two snaps at the front and that comes out very easy as well. ill give you a quick look at the interior of the helmet here . You can probably see there are some holes for the ventilation to come through to reach the skin on your head . And i do want to talk about as i mentioned in the beginning of the video, there's some features on this helmet to help customize the fit a little bit. This is the crown liner they actually provided some tear away pads on the sides of the temple so this is a long oval helmet and what that means is its for people with a longer head front to back and it eliminates hot spots on the forehead however everyone's temples are different as well some people have sunken temples some people have protruding temples . If you find this helmet fits great front to back but its a little bit tight on the sides , there are 5 millimeter pads in both sides so you can actually remove this it just comes right out and you can do that on both sides and that's going to give you just a little bit more room side to side and provide you with a very nice custom fit. Another thing you'll notice about this liner is it is completely open along the top and then that's just going to work with conjunction with the venting on the helmet to provide you with a lot of air flow. Next thing i want to show you is the cheek pads and i can actually remove the cover off of one of these and show you they actually use multiple layers , it doesn't come all the way off but, they use multiple layers of foam they call this the facial contour system . Basically you can see how its not just a flat single piece of foam like in cheaper helmets where basically it just kind of squishes on to your head you know you hope its comfortable, this has several layers of foam its contoured to cradle your face and then Arai has done something very innovative and they have basically put a spring inside this you can see as i press on that it gives . There's a couple things that does One when your pulling the helmet on and off its going to move the cheek pad out of the way your not feeling like your ripping your ears off every time you pull your helmet off but Two once the helmets on this spring is going to push back and its just going to give you a nice cradled feeling around your chin and your jaw bone and that's going to obviously provide a lot of comfort but it also reduces wind noise . Any time you have a better seal around the base of your helmet and around your face feel around the base thats a significant way to reduce wind noise its a very innovative feature i think a lot of people are going to really appreciate what that does for them . Now i don't have the interior of a Signet Q to show you but i do have one for the RXQ and i want to try and show you basically what Arai does in their construction that really sets them apart from everyone else . First is the EPS liner , you'll notice there's some different colors of foam here basically they have multiple densities of foam built into the liner but its a single piece . You can see their are denser parts of foam then there are softer parts depending on where you hit your head how you hit it if its a hard impact or just a lighter impact this is designed to dissipate the energy as much as possible so its going to spread the impact and its also going to cushion your head in an impact you can also see the ventilation holes , and again the RXQ is going to be very very similar to the Signet Q because they have basically based the Signet off the RXQ its just going to be a little bit longer front to back . The other thing that i have up here is the shell itself Arai uses what they call super complex laminate construction its basically a blend of fiber glass and other materials . There's a few things you'll notice about it when you actually pick it up an hold it but the biggest thing about Arai helmets is they are incredibly incredibly strong this is obviously not a complete helmet its a shell but still its incredibly stiff i mean i can push very very hard on the chin bar here and its not giving at all it is a very very stiff shell and what that's going to do for you again is dissipate energy in impact its going to spread the energy to a larger area so that you don't get injured . You'll also see that they have some other layers of material on the top of the shell , So again different parts of the shell are reinforced in different ways they use a ridge around the chin bar and around the base of the helmet just again provide that level of stiffness , and another thing you'll notice about Arai and this is huge for them their shield changing mechanism does not interfere with the shell that's why they have the pods on the sides. Instead of having a big recess here that might compromise the safety of the helmet its basically just a flat uniform piece it does go in just a tiny bit but if you compare that to other helmets some have a significant dip here where it might compromising the entire shell . Arai looks at the structure of an egg and that's what they base their shell shape off of.They keep it very simple very rounded so that it will prevent any weak spots on the shell itself and again that's just part of what your paying for with Arai i mean we know they are not cheep helmets , but again you do get what you pay for. So that's the Arai Signet Q in a nut shell again were very excited to see this in their line up a lot of people were having trouble with the Arais not fitting them if you have more of a long oval head shape because the Signet was not in the line up but they brought it back so were excited to see it. You can check these out online at Competition Accessories .com And well see you next time.
Product Details
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Information and Details about the Arai Signet-Q Laurel Helmet
made by Arai
On the outside, the Arai Signet-Q Laurel Helmet looks very similar to it's namesake, the RX-Q, but on the inside you can see and feel the difference. Arai Signet-Q Laurel Helmets take all the favorite features of the RX-Q and create a whole new series based on all the successes. A longer shell shape on the Arai Signet-Q Laurel Helmet gives 5mm more space front to back allowing for a larger number of heads to fit comfortably. Arai Signet-Q Laurel Helmets release forehead pressure and eliminate hot spots for a more comfortable fit every time.
Like in ancient Greece, the Arai Signet-Q Laurel Helmet places a golden wreath of laurels about the helmet's crown atop a black and white colorway to signify a victor. If you would like to be a victor or just appear so, then the Arai Signet-Q Laurel Helmet was made especially for you.
A helmet is first and foremost an Energy Management System. From ventilation to aerodynamics, shield systems, radio, blue tooth and graphics – everything comes secondary, and none should ever interfere with the helmet's number-one job of Impact Energy Management!
Arai looks to the incredibly strong shape of an egg for inspiration, with the smooth uninterrupted spherical shape transferring stress loads more evenly across it's entire surface. The absence of exaggerated edges or protrusions in the shell is not a lack of creativity, but an commitment to maintaining the integrity of the shell with impact performance in mind.
Additional Features of the NEW
Arai SignetQ
Both the top vent set and side exhaust cowls are direct carryovers from the RX-q
Brow vent ducting redirects to flow air across the temples
DDL-4 exhaust vent to the 10mm wider eye port (5mm on each side)
Long Oval Fit with the
Arai Signet-Q
SAI MAX-Vision "Brow Vent†shield
Clear Pin Lock Max-Vision Brow Vent anti-fog lens Included with the helmet
Elongated shell adds 5mm from front to back
Long-Oval shape helps prevent "Hot-Spotâ€
Multi-Density Single piece EPS liner
Removable, replaceable, washable interior
Dry-Cool Surface material for rapid displacement of heat and moisture away from your head and into the ventilation airflow for added comfort while riding and a quick dry between rides
5mm peel-away temple pads adds another level of customization, giving the helmet interior a little extra width when needed
Enhanced for customizable micro fitment interior without the need to purchase extra interior components
Arai Signet Q Laurel Graphic has the New FCS (Facial Contour Support) cheek pad design
Innovative and exclusive spring support adds just the right amount of pressure when needed while being worn
Meets or exceeds
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Competition Accessories is a company of core motorcycle and ATV enthusiasts who are dedicated to bringing the best possible shopping experience to every rider that visits our stores. After all, We've been shipping motorcyclists their motorcycle helmets, motorcycle jackets, gloves, boots and other motorcycle accessories for over 50 years. You don't hang around that long in any business without taking care of your customers and changing with the times. So trust that we will deliver and if we screw up, we will make it right... We promise!
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Sleuth troubled, at times mad
Updated 1:59 pm, Monday, March 18, 2013
"Mad Men" fans used to Elisabeth Moss in her signature role of calm, buttoned-up Peggy Olson are in for a real jolt.
In Jane Campion's gritty and mysterious seven-part miniseries, "Top of the Lake" (debuting with two episodes at 8 tonight and continuing for several Mondays on Sundance Channel), the actress trades suits and gentility for scruffy T's, jeans and an in-your-face attitude.
Moss plays troubled and daring police Detective Robin Griffin. She's threatened, bruised and pushed into violence as she makes her way across treacherous landscapes in New Zealand to investigate the disappearance of a pregnant 12-year-old girl.
The actress described the experience as fun and "all very, very raw" — including one extremely rough scene in a bar. There, she has an encounter with one of the town sleazes, cuts him with broken glass and is carried out kicking and shouting. "It was really hard technically with the 'glassing' and everything to make it look real," she said at a Sundance press session. "I was bleeding and I had bruises the next day and my voice was gone and, sorry to say, but that stuff's really fun for an actor. It's kind of what you gear yourself up to get to do.
Returning to "Mad Men" for season six was comforting. It was like "coming home," she said, while each day on "Top of the Lake" "was like the acting Olympics ... every day was a new challenge physically and emotionally."
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Her co-star Holly Hunter also spoke of the challenges. In "Lake," she plays a kind of sage, the leader of a group of emotionally scarred women in a place called Paradise. Hunter, who, in person, looked about 25 in long brown locks and mod mini-dress, is virtually unrecognizable as GJ, a 60-plus woman with hip-length silver hair, an otherworldly manner and a wicked candor that leaves you startled with every sentence. She found reuniting with Campion, who directed Hunter in her Oscar-winning role in "The Piano," deliciously exhilarating.
"When I work with Jane, it's kind of like falling in love with someone, you know, but you're falling," she said. "And you might stumble and she might push you or you might leap, but you're falling. And it's deep and dark and fun."
The miniseries, in fact, is full of striking characters, some brutish and scary, others vulnerable with painful secrets.
Among the latter is Tui Mitcham, the girl who goes missing after a doctor finds that she's five months pregnant. The girl is questioned by Detective Griffin, but refuses to give the name of the father. High on the list of suspects is her father, Matt Mitcham (the marvelous Peter Mullan), a crude and blustery drug lord who aggressively berates his daughter when informed that she's expecting a baby. Whenever this man appears on screen, in fact, you feel a sense of dread, that violence is sure to erupt.
The series also is full of explicit language and sexual boldness. In a stunner of a scene early on, one of the hurting ladies from Paradise slaps some money on the bar, saying it's for any man who'll give her a quick, emotionless roll in the hay in one of the bedrooms upstairs.
Some would say the miniseries' most important character, however, is New Zealand; here, the land comes through as fantastic, fierce and, at times, frightening.
Moss said she felt fortunate to have experienced such an adventurous shoot, calling "Top of the Lake" the most comprehensive documentation of modern New Zealand ever been done on such a large scale. People are so used to "The Hobbit" or "Lord of the Rings" and that beautiful representation of the country, she said.
But in this portrait, she added, "we show a very different and much more modern, and much more raw side ... we went everywhere. And when you're out in the bush or when you're on a mountainside and when you're standing in the middle of that freezing lake, you do get to experience the landscape in a way that I think no tourist ever really could."

subset: commoncrawl


text:
Allogeneic Stem Cell Transplantation for the Treatment of Multiple Sclerosis (Compassionate Use)
Expanded access is no longer available for this treatment.
University of Louisville
Duke University
Information provided by (Responsible Party):
University of Louisville
ClinicalTrials.gov Identifier:
First received: March 7, 2014
Last updated: March 17, 2017
Last verified: March 2017
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- How to Read a Study Record
A subject was treated under compassionate use provisions under this study with facilitating cell therapy (FCRx) product manufactured using the CliniMACS (Miltenyi Biotec) device, rather than the Max Sep (Baxter) device.
|Metachromatic Leukodystrophy
|Biological: Enriched Hematopoetic Stem Cell Infusion
|Study Type:
Expanded Access
What is Expanded Access?
Available for Individual Patients
|Official Title:
|Allogeneic Stem Cell Transplantation for the Treatment of Multiple Sclerosis (Compassionate Use)
Resource links provided by NLM:
Genetics Home Reference related topics: RNAse T2-deficient leukoencephalopathy leukoencephalopathy with vanishing white matter megalencephalic leukoencephalopathy with subcortical cysts metachromatic leukodystrophy multiple sclerosis
MedlinePlus related topics: Leukodystrophies Multiple Sclerosis
Genetic and Rare Diseases Information Center resources: Leukodystrophy Metachromatic Leukodystrophy SphingolipidosisU.S. FDA Resources
Further study details as provided by University of Louisville:
|Ages Eligible for Study:
|3 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
Inclusion Criteria:
Patients must have a confirmed diagnosis of inherited metabolic disorder / inborn error of metabolism. Diagnosis should be confirmed by appropriate test(s) (enzyme and/or mutation analysis) before study entry. Patients must not be eligible for myeloablative chemotherapy as a preparative regimen for transplant due to age, co-morbidities or organ dysfunction.
Inborn errors of metabolism / Inherited Metabolic Disorders (IMD) eligible for this Compassionate Use Provision include Metachromatic Leukodystrophy (MLD)
- Patients must be ≥ 3 years of age
- Patients must have Lansky or Karnofsky performance status ≥40
Patients must have adequate function of other organ systems as measured by:
- Creatinine < 2.0 mg/dl and creatinine clearance ≥60 cc/min/1.73m2. Newborns must have a creatinine clearance > 25 cc/min. For babies < 3 months of age, the raw value on glomerular filtration rate (GFR) must be > 1 cc/kg/min.
- Hepatic transaminases (ALT/AST) ≤4 x normal, bilirubin <2.0mg/dl
- Normal cardiac function by echocardiogram or radionuclide scan (ejection fraction or shortening fraction >80% of normal value for age)
- Pulmonary function tests demonstrating forced expiratory volume at one second (FEV1) of >50% of predicted for age. If child is too young for pulmonary function tests (PFTs), crying vital capacity result of >50% of normal value for age or resting pulse oximeter >85% on room air or clearance by pulmonologist will be required.
- Patient must have a related donor [identical or mismatched for 1, 2 or 3 histocompatibility leukocyte antigen (HLA)-A, -B or -DR loci].
- Patient, and parent, or legal guardian must have given written informed consent according to FDA guidelines.
- Patients must have a minimum life expectancy of at least 6 months.
- Female patients of childbearing potential cannot be pregnant or lactating/breast-feeding and must be either surgically sterile, postmenopausal (no menses for the previous 12 months), or must be practicing an effective method of birth control as determined by the investigator (e.g., oral contraceptives, double barrier methods, hormonal injectable or implanted contraceptives, tubal ligation, or partner with vasectomy).
Exclusion Criteria:
- Patients with uncontrolled seizures, apnea, evidence of recurrent or uncontrolled aspiration, or need for chronic mechanical ventilation.
- Patients with allogeneic stem cell transplant with cytoreductive therapy in the past 6 months.
- Subjects must not have had previous radiation therapy that would preclude total body irradiation (TBI) (as determined by radiation therapist)
- Uncontrolled infection or severe concomitant diseases, which in the judgment of the Principal Investigator, could not tolerate reduced intensity transplantation.
- Severe impairment of functional performance as evidenced by a Karnofsky (patients >16 years old) or Lansky (children <16 years old) score <40%
- Subjects with a positive human immunodeficiency virus (HIV) antibody test result
- Subjects who are pregnant, as indicated by a positive serum human chorionic gonadotropin (HCG) test
- Subjects whose only donor is pregnant at the time of intended transplant
- Subjects of childbearing potential who are not practicing adequate contraception as defined by the investigator at the site
- Jehovah's witness
- Patients that have any comorbid condition which, in the view of the Principal Investigators, renders the patient at too high a risk from treatment complications and regimen related morbidity/mortality.
- Lack of related donors
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02084121
Please refer to this study by its ClinicalTrials.gov identifier: NCT02084121
|United States, North Carolina
|Duke University
|Durham, North Carolina, United States, 27705
Sponsors and Collaborators
University of Louisville
Duke University
|Principal Investigator:
|Joanne Kurtzberg, MD
|Duke University
More Information
Keywords provided by University of Louisville:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 19, 2017
|Responsible Party:
|University of Louisville
|ClinicalTrials.gov Identifier:
|NCT02084121 History of Changes
|Other Study ID Numbers:
ICT-13080-Compassionate Use
|Study First Received:
|March 7, 2014
|Last Updated:
|March 17, 2017
Keywords provided by University of Louisville:
metachromatic leukodystrophy
Additional relevant MeSH terms:
Leukodystrophy, Metachromatic
Multiple Sclerosis
Pathologic Processes
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Hereditary Central Nervous System Demyelinating Diseases
Brain Diseases, Metabolic, Inborn
Brain Diseases, Metabolic
Brain Diseases
Central Nervous System Diseases
Lysosomal Storage Diseases, Nervous System
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Lipid Metabolism, Inborn Errors
Lysosomal Storage Diseases
Metabolic Diseases
Lipid Metabolism Disorders
ClinicalTrials.gov processed this record on September 19, 2017


text:
Brad Pitt
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text:
You helped me in 2006 with a "preheat" issue with this same electric range (see Oen Preheat—Kenmore Model #911.93578) and now I have another issue with this same range.
I thought I was imagining it but it appeared that perhaps the right front [high putput] burner was still on when in fact it was set to the 'OFF' position with the safety control "popped out". Still, I felt some heat. Either that or it was cooling down very slowly.
First up, have you ever heard of this type of behavior with an electric range? Secondly, if that's the case, is there an adjustment that can be made to the control to make certain where it "pops-out" is, in fact, the 'OFF' position? Or, lastly, do you recommend a total switch/control replacement?
Any help would be greatly appreciated. Thanks!
Rochester, New York U.S.A.
[email protected]


text:
Freese not concerned with low spring numbers
MESA, Ariz. -- Angels third baseman David Freese was a late scratch from Tuesday's lineup against the Cubs because of tightness in one of his quads, which means he'll leave Arizona without an extra-base hit. Freese, whose injury isn't deemed serious, finished his first stint of Cactus League play batting .250 in 44 at-bats -- five months after posting only a .526 OPS in 17 playoff games with the Cardinals.
Those numbers don't coincide with how he feels, though.
"I'm liking how I'm driving it," said Freese, who will be in Southern California on Wednesday and is expected to play in the Freeway Series opener against the Dodgers on Thursday. "Obviously I'm not getting a lot of results, but I'm hitting hard line drives for singles. They'll find the gaps in the season. I'm putting some good wood on some balls to right that are getting caught, but I'll take that now."
Freese points to his seven walks, compared to six strikeouts, and notices that he can get "deeper into his base" and use his legs more now that his back isn't bothering him like it did in 2013.
He also recalls the spring of 2012, when he was coming off being the Most Valuable Player of the National League Championship Series and World Series, then batted only .188 in the Grapefruit League and went on to have his most productive season in the Major Leagues, batting .293/.372/.467.
"Every year it's different [in Spring Training]," Freese said. "It is what it is. You keep working, and when the lights come on, you're ready."
Alden Gonzalez is a reporter for MLB.com. Read his blog, Gonzo and "The Show", and follow him on Twitter @Alden_Gonzalez. This story was not subject to the approval of Major League Baseball or its clubs.


text:
Alvarado Baby Bodysuits are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Alvarado Baby Bodysuit for a special occasion, give a Alvarado Infant Bodysuit as a present or need to represent with a funny Alvarado Baby Romper during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Alvarado Baby Bodysuit for you! Even if it turns out you can't find the right Alvarado Baby Creeper with the perfect design for all those babies in your family and friends circle; Idakoos offers all of its children's Alvarado Baby Bodysuits as Alvarado Baby Bodysuits. Personalize any Alvarado Baby Snapsuit the way you want to ensure the perfect gift.
Showing 1 - 24 of 74 Baby Bodysuit


text:
Last week we showed you an Aprilia SXV dressed up as a Ducati
Hypermotard that Tom Cruise was riding on the set of "Knight and Day." A
bit embarrassing for Ducati, right? It was and it caught them by
surprise, they didn't know about the bike and didn't know why it was
being used. Now, with Ducati's help, we've gotten to the bottom of the
story. Turns out it wasn't the Hypermotard's ability that was the
problem, it was Cruise's.
Update: Greg Smrz responds in comments. Looks like the Ducprilia was used in the film.
According to Ducati and "Knight and Day's" stunt coordinator, Greg Smrz, the Ducprilia was at no point used for any scenes in the movie.
What the Aprilicati was created for was an ESPN promo in which Cruise himself decided to do a 30-foot long, 3-foot high jump on camera. Apparently the looney tune is a good rider, just not up to the standards of a movie stunt person and there was obviously some concern for his well being, helmetless jumps and all. Thus the SXVtard.
"He isn't as good a rider (although pretty good from what I hear) as the stunt guys, so they tried to make it at light as possible by using the Aprilia, and having a dummy passenger to make it easier and safer for him," explains Ducati. "It shaved 40% of the weight. They looked at pure dirt bikes as a cheaper alternative but the Aprilia was easiest to make look like the Hyper."
Greg Smrz explains further, "If you will note, there is a 50lbs dummy on the back of Tom's motorcycle. The reason for this is weight. In addition, the Aprilia has longer travel suspension."
That's right that weird-looking blonde chick on the back is actually a 50lbs weight intended to shift the bike + movie star + dummy's center of gravity backwards, ensuring the rear wheel would hit first when Cruise landed.
So if you see a Ducati in the film, it's a Ducati, albeit likely a heavily modified one. According to Ducati, the bike's ability to stick huge jumps was boosted by, "totally different fork, shocks, link, rear subframe, weld beads on engine mounts, re-enforced steering head and swingarm mounts." If you see a Ducati doing unrealistic things in the movie though, that's probably CGI.


text:
Double date in "And The Married Man Sleepover" S3 E17
Caroline asks Max and Deke to join her on her dinner date at Nicolas's loft to help make sure she doesn't do anything she might regret. Also, Max and Caroline treat themselves to very special hair appointments, on 2 BROKE GIRLS, Monday, Feb. 24 (8:30-9:00 PM, ET/PT) on the CBS Television Network. Nicolas (Gilles Marini), from left, Caroline Channing (Beth Behrs), Deke (Eric Andre) and Max Black (Kat Dennings), shown. Photo: Cliff Lipson/CBS ©2014 CBS Broadcasting, Inc. All Rights Reserved


text:
Babyletto has been making quality nursery furniture for twenty-two years. With an emphasis on safe, modern and eco-friendly baby furniture, Babyletto has quickly become a leader in trendy furniture for the new baby. At Babyletto, paints used are less than 2ppm toxicity level which drastically less than the government-deemed "safe" level of toxicity at 300ppm. This means Babyletto uses industry-leading paints with teething babies in mind. Safety always comes first with Babyletto.Read More
A Babyletto chest adds just the right touch of urban flair to your baby's new bedroom. The simple design of the Babyletto chest will help create a soothing place of rest, which is exactly what you and your littlest one will need.
Recessed drawer pulls means no snagging clothes on knobby handles and nothing that can be ripped off when your child decides to test his strength. Chunky squared legs add that extra bit of stability. Five chest drawers offer a wonderful place to store a large infant wardrobe. As he or she gets older, your little one can use the chest to organize his clothes into neat little stacks. Your little fashionista will love the fresh and trendy finishes and the cool simple look of a Babyletto chest dresser. Five chest drawers for her may not be enough to clear her closet but it's a start.
Babyletto chest dressers are available with your choice of the very trendy espresso finish as well as a combination of white drawers fitted inside an espresso base. Both Babyletto chest dresser finishes are very hot trends right now and will match nearly any dark or light themed room quite nicely.
Cymax provides the base which any savvy online shopper can use to find the perfect piece of trendy furniture for the home or office. Seek out your newest design favorites from top brands such as Babyletto and many more at highly competitive prices. Free shipping on most purchases provides the perfect platform from whence your budget can dive into the pool of cost efficiency.


text:
Probably not, but then that is a discussion for a different sub-forum.Alex123 wrote:porpoise wrote:So why do you think this phrase is included? And is it actually referring to an aspect of mindfulness, or to an additional quality?
IMHO, one needs to remember Dhamma principles (such as anatta) when observing the present states.


text:
As I understand it, in Vajrayana Buddhism there is the potential for finding oneself in Vajra Hell.
Tantric Buddhists are in the position of a snake inside a bamboo tube; one hole faces up to the Dharmakaya, the other down toward Vajra Hell. There are only two options -- up or down; no in-between. Keeping samaya (commitment) determines which way the snake slides.
Source: http://www.khandro.net/TibBud%20_vajrayana.htm
A few questions...
1. Is Vajra Hell a place or a state of mind?
2. Does it correlate to any of the planes of existence (e.g. Avici Hell) taught in Mahayana or Theravada Buddhism?
3. Is Vajra Hell a "scare tactic" to encourage practitioners to maintain samaya, or the geniune kammic consequence of breaking samaya?


text:
Wrestlemania 30 - New Era.
The night after Wrestlemania 30 the WWE have the chance to create a new era. They have the chance to make Mania 30 the biggest of all time, maybe The Undertaker will have his last match, maybe HHH will have his last match. We could be looking at a new era where the WWE moves along with the younger talent moving into the main event spot challenging for the WWE
© 2011 eWrestlingNews, All Rights Reserved.


text:
Oil rose towards $117 a barrel on Tuesday, resuming its three-week rally, as investor concern faded about political risks in the euro zone that had prompted a sell-off of riskier assets in the previous session.
European shares moved up and the euro rose after better-than-expected euro zone PMI figures. Shares of British oil giant BP were up 1.7 percent after its fourth-quarter results beat expectations.
Brent crude was up $1.15 a barrel at $116.75 at 1215 GMT after falling as low as $115.01 earlier. It has gained over 4 percent in 2013 and reached a more than four-month high above $117 on Friday. U.S. crude added 88 cents to $97.05.
"We do not envisage prices receding for any great length of time," said Carsten Fritsch, analyst at Commerzbank. "The supply-side risks still prevailing, shrinking OPEC supplies and the brightening global economic outlook all suggest that such a retreat is unlikely."
Lower output from the Organization of the Petroleum Exporting Countries has reduced an expected global supply surplus in 2013, while fighting in Syria and Iran's dispute with the West over its nuclear work continue to pose the risk of wider disruption to Middle East supply.
Oil fell on Monday alongside the euro and equities as a rise in political uncertainty in the euro zone weighed on sentiment. Analysts said Iran's offer of fresh talks with the West also dampened oil prices.
Iran and world powers on Tuesday announced new talks were scheduled for Feb. 26, but hopes of progress were tempered when an Iranian official said the West's goal in talking was to undermine the Islamic republic.
In Spain, the prime minister is facing calls to resign, while in Italy, which is having elections this month, former prime minister Silvio Berlusconi is seeing a resurgence in popularity.
Some dealers say crude may struggle to rally much further, seeing little in the supply and demand balance to justify higher prices.
"The market has perked up a bit, but I suspect the quite sustained rally we saw last week is running out of steam now and fundamentals will be reasserting themselves," said Christopher Bellew, a broker at Jefferies Bache.
"There seems to be plenty of crude around. The market is fairly well balanced, so it should not be in an upward spiral because of any lack of supply."
Oil traders awaited a report on U.S. oil supplies later the day. U.S. crude stocks are expected to rise by 2.8 million barrels, a preliminary Reuters poll found on Monday.
Industry group the American Petroleum Institute releases its report on Tuesday, while figures from the government's Energy Information Administration follow on Wednesday. (Additional reporting by Ramya Venugopal in Singapore; editing by James Jukwey)


text: State Senate votes to limit landowner liability By The Associated Press March 5, 2013 Story Share CHARLESTON, W.Va. -- The West Virginia Senate unanimously passed a bill Tuesday that would ensure property owners face very limited liability from trespassers on their land.In general, common law states that property owners cannot be sued by trespassers unless they recklessly or willfully injure the trespasser. The bill would lock that common law into written legislation.The bill is in response to a recent publication of the non-binding but very influential American Law Institute. That publication, "Restatement of Torts, Third,'' dissolves some of the legal distinctions between trespassers and regular invitees. It would protect property owners against suit from "flagrant'' trespassers, but in many cases, other trespassers would have the same legal standing as regular invited guests.Judges and lawyers often rely on the Restatement of Torts to help them interpret common practices and nuances in the law.Michael Greene, a professor at Wake Forest University School of Law, worked on the Restatement of Torts and said it is important to distinguish between different types of trespassers."Plainly, somebody who comes down your chimney to rob you is a trespasser,'' Greene said. "But then there are other kinds of trespassers. The kid who cuts across your yard to get to school is a trespasser.''A child who ran across property would, under current common law, probably be exempted from the West Virginia bill, but Greene gave another example of a trespasser who would likely not be protected."There's a park in Rhode Island that has a cliff-side walk where you can look out,'' Greene said. "And you're walking along this path. The park closes at 9 o'clock or 10 o'clock. There was somebody walking along that path and, because it was not maintained, he fell and was either killed or badly injured. He was a trespasser because the park was closed.'' Sen. Corey Palumbo, D-Kanawha, and the bill's lead sponsor, said that the bill is intended to make sure the law stays the same and judges aren't influenced by the Restatement of Torts."The purpose of the bill is to make sure there is no change,'' Palumbo said. "The current law in West Virginia is you owe a duty of care to invited guests but the duty to trespassers is much, much lower, much different. This bill is saying that's how we think it should stay.''George Christie, a professor at Duke University School of Law, said that the intentions of the Restatement of Torts are admirable, but because "flagrant trespassers'' is left undefined, there could be unintended consequences."I have doubts,'' Christie wrote, "as to whether the solution chosen will fulfill the expectations of its drafters."Since the Restatement of Torts was published, 11 states have responded by passing statutes codifying their existing common law. Many of those states worked off of model legislation proposed by the American Legislative Exchange Council.ALEC is an organization of legislators, businesses and foundations that proposes and promotes conservative and free-market policy ideas to state legislatures around the country.The language in the West Virginia bill is strikingly similar, almost identical in places, to a piece of model legislation written by ALEC. Palumbo said he was not sure if they had worked with ALEC on the bill. Amy Anderson, an ALEC spokeswoman, said she had not been contacted by anyone in West Virginia. Story Share Story Share Trending Now 1 Teen pleads guilty to involuntary manslaughter in Oakes Field shooting 2 Toyota announces new $115 million project for WV plant 3 Facebook founder visits Cabin Creek Health Systems 4 'Report for America' pilot project begins in Appalachia 5 Congressional opioid investigation targets drug wholesaler Miami-Luken LGBT group rallies for protection from discrimination Previous Story State lawmakers quiz officials on school safety Next Story


text:
Day 8 (Wednesday) of the camp.
The intermediate group continued to work on Deniya, including three different breaks, which took up most of the session. Towards the end, Mamady demonstrated the parts for a new 4/4 rhythm called Balandugu Sila. The rhythm was inspired by the trip to Balandugu where Mamady did a pyramid with his students. (If you buy a copy of the volume 4 DVD, there is a great documentary in the bonus material about that trip. Also, listen to Taylor's interview, where he tells a few stories about the horror trip they had to get there. It took forever due to bad roads and technical problems with the cars.) The intermediates will start learning this rhythm tomorrow.
The advanced group finished off Yankadi. At the end of the session, Mamady improvised to Yankadi, which was a joy to listen to. Technically quite simple phrases, but they are placed "just so" and flow out with effortless grace--it's a pleasure to sit there, listen and soak it all in. I've posted a recording of Mamady's solo in the media section.
This afternoon, we completed the pyramid. So far, it was Sira, Djaa, Djansa, and Macru. Today, Mamady added Fe 3 and Denadon, both with nice intros and breaks. It really sounds cool now--I'm very happy with how he mamaged to bring this home; at the end of last, week I was quietly thinking "Eell, we have a 3-minute break and nothing much else, and only five days left. Where the hell is the rest of the pyramid going to come from?" Just goes to show how much more Mamady knows than I do...


text:
We are all getting excited here about the 2012 CityRead. Library staff is encouraging everyone in the community to pick up a copy of "Locked Rooms: A Mary Russell Novel" by Laurie R. King at the library. We are into our third week, and have handed out 450 copies of the book already!
Our culminating program this year is a talk by the author at 2 p.m. Oct. 21 at the new Community Center at 35 Oak St. Barnes and Noble will be on hand to sell King's books, and she will sign them.
In addition to our annual author talk, we have added one additional program this year. Geology professor Mitchell Craig from CSU East Bay will lead a talk about the 1906 earthquake on Oct. 16 at 7 p.m., also at the Community Center. The 1906 earthquake plays a major role in "Locked Rooms," and we hope to provide some background about it at this program.
This year's CityRead has a great deal of community support. The Rotary Club of Brentwood, the Lions Club of Brentwood, the Brentwood Art Society and the Friends of the Brentwood Library have all contributed to the book purchase this year. In addition, Poets & Writers Inc., through a grant from the James Irvine Foundation, is providing a matching grant to cover half of the author's fee.
We have also had volunteer help from local students who have labeled all of the books, added bookmarks to the books, and set the books up in baskets for distribution in the library.
Last but not least, the city of Brentwood continues to assist us with its generous discount for use of the Community Center.
Library expansion
On Sept. 25, the Brentwood City Council voted to proceed with the expansion of the library. Hurray! The library is housed at 104 Oak St., across from the new City Hall. Now that the city offices next to us are empty the library and the city will work together to move into about half of the adjoining space, to create a combined space of about 11,000 square feet.
Family programs
Oakland Zoomobile will be at the Prewett Library in Antioch at 2 p.m. Oct. 10.
Come explore habitats and the animals that are built to thrive in them. You will be a whole different mammal after this trip! Sponsored by the Friends of the Antioch Library, the event takes place in the West Island Room of the Antioch Community Center.
Lego Party With Bricks 4 Kids at the Antioch Library: This will be at 3 p.m. Oct. 17.
Bricks 4 Kidz is back with another special project and fun blocks for the little ones as well. Come early as the room fills up quickly!
Halloween Party!: Presented by the Brentwood Library, the program is at 4 p.m. Oct. 17.
It's baaaaaaaaack! Ghosts and goblins, put on your costumes and fly to this spooktacular event! Held in the Brentwood Community Center at 35 Oak St.
Movie Saturday at the Oakley Library: The event will be from 3 to 5 p.m. Oct. 27.
Stop in for a Disney Halloween double-feature movie extravaganza. For preschool and older.
Halloween Howl La La Boo at the Oakley Library: The event will be at 6:30 p.m. Oct. 30.
Join us for our annual howling Halloween spectacular hosted by the Oakley Library Youth Squad! We'll serve up some spooky stories, creepy crafts, and ghostly games. Don't forget to come dressed in your hair-raising Halloween costumes for the Costume Contest. You don't want to miss this spine-tingling Howl La La Boo!
Liz Fuller is a community library manager at the Brentwood library. Reach her at 925-625-3589, 925-516-5294 or at firstname.lastname@example.com.


text:
NORTH Bundaberg residents are running on empty.
Physically, they're drained. Emotionally? Even more so.
In the space of a week, they've seen their neighbourhood transform from a quiet community into a raging river and, finally, to a disaster zone akin to something that might come out of Hollywood.
Luxury yachts lay strewn along the banks of the Burnett River, where the relentless flow of water tossed them aside like a child might scatter his toys during a tantrum.
In town, putrid mud coats almost everything in sight.
Stagnant ponds have formed in sunken roads, furniture rests precariously in trees and some homes have disappeared completely.
Council estimates the damage bill to be at least $200 million.
It's not uncommon in the streets of North Bundaberg to see an old woman burst into tears, a grown man shout in frustration or a couple hold each other as they wander aimlessly through rubble.
But somehow, residents have found the strength to start the arduous clean-up.
As soon as the Burnett Bridge, which links the obliterated suburb to the CBD in the south, was completely opened on Sunday morning, a stream of cars began filing over.
Some waiting in the several kilometre-long line just wanted to start getting their homes back in order.
Others will be assessing whether they want to go back at all.
The queue included soldiers, tradesmen and emergency workers, intending to repair infrastructure damage.
Most, however, were people from elsewhere in Bundaberg, thanking their lucky stars they weren't in the same disastrous situation and ready to lend a hand.
More than 700 residents joined a council-organised mud army to take to the streets.
Co-ordinator Glenn Hart describes the volunteers with the only word he thinks is fitting - inspirational.
"The way the volunteers interacted with those affected community members showed the kinship that exists in our community," he says.
And going by the mood of those who lost everything in the flood, they need all the support they can get.
Jordane Buchanan questions how he will tell his autistic four-year-old son what has happened as he sweeps thick sludge out of his front door.
"His teddy bears were stuck inside and that's his life," he says.
"He won't be able to get over it."
Lifelong Bundaberg resident Harry Hartfiel tries to process what he is seeing as he stands in the middle of what used to be a street.
"It's like we're standing in the middle of a third world country," he says.
"I've never seen anything like this."
Dorothy Cox provides yet another harrowing insight into how people are feeling as she picks through sludge in the garden of what was her newly renovated home, muttering: "Nothing matters anymore."
Bundaberg, the worst hit city in Queensland's flood crisis, has been a mecca for politicians who have come to stand in front of cameras with offers of help.
Premier Campbell Newman appointed deputy commissioner Brett Pointing as the region's disaster recovery coordinator, Prime Minister Julia Gillard committed federal funds and Opposition Leader Tony Abbott called for more loans and tax breaks for affected businesses.
But having too many people in charge and trying to help almost backfired last week when a communication breakdown between police and council saw residents told they could return home to north Bundaberg, only to have the offer withdrawn hours later.
Angry, frustrated and tired, residents stood at the entry to the bridge demanding to be allowed over.
"This whole thing is just a joke," Ross Thiele fumed at the time.
"If they weren't ready for us to go over, why even say anything at all?"
Others were heard shouting more colorful words to describe the situation.
But for now, tensions have subsided as people focus on the gargantuan clean-up task ahead.
It could be months before residents can actually move back into their homes. If they are even inhabitable, they are without water, sewerage or power.
In the meantime, they have temporary homes at a makeshift tent city in the showgrounds.
Lisa Marsh says the caravan she shares with her two young children contains everything she owns.
"This is our home now, this is it," she sighs.
"But there's no point complaining, we just have to get on with it."
It's a motto that appears to be working for most Bundaberg residents.
Originally published as North Bundaberg locals drained


text:
Oakley, Is a fusion of art and science. They are leaders of innovation that deliver high performance Goggles for athletes around the world. Founded in 1975, Oakley has become a staple brand because of their reliability, quality, and technology that keeps improving year after year. Their mission: "To provide snow athletes with the absolute highest level of optical clarity."
Oakley offers a variety of lens tints that combine filtering, color balance and visual contrast that maximize performance in any light condition. These high performance tints are combined with High Definition Optics (HDO). HDO provides distortion free vision that is the most true to your eye's natural vision. Not only will you see clearly but Oakley lenses contain Impact Protection which has been tested and approved by the military.
This season, Oakley is releasing their all new Flight Deck which is inspired by fighter jet pilots. This goggle provides the widest field of vision for spotting hazards and any challenges that might be in your path. The Flight Deck has an interchangeable lens system that allows you to switch your lenses on the fly to suit any lighting condition throughout your adventure.
With over 30 years of snow goggle innovation, Oakley continues to pack their goggles with, pride, passion, and obsession to bring snow athletes what they need to enjoy the mountain.


text: So i just picked up a new Roc 3 (hada have it) and noticed it flew much like my Champion USDGC Roc+ and looking at the two they seem identicial. I'm kinda new, so can someone please tell me what i'm not seeing or missing? Other then marketing, whats the differance?


text:
Topic: Medical Advisory Counsil Update
We are grateful to have the support of these distinguished physicians and those not yet listed, but are in the process of being added.
http://www.cholangiocarcinoma.org/medic … ouncil.htm
cholangiocarcinoma.org :: Cholangiocarcinoma Foundation Discussion Board
a resource for patients, friends, caregivers and loved ones.
You are not logged in. Please login or register.
|La fundación de colangiocarcinoma (CCF) ahora ofrece servicios de traducción en Español.
Por favor publique sus preguntas en Español y un intérprete le va responder.
Join our new Mentoring Program
A new discussion board experience is coming this September!
After 10 years, we're upgrading our discussion board to a new modern system. The new forum will be easier to use, mobile-friendly and loaded with new features! We'll be taking all of the existing posts and users over to the new board, you won't have to do anything. If you have any questions, we've started a thread here to discuss.
We are grateful to have the support of these distinguished physicians and those not yet listed, but are in the process of being added.
http://www.cholangiocarcinoma.org/medic … ouncil.htm
Marion this is VERY impressive. BTW Dr. Javle could be a twin to my Dr. Mahajani my GI guy! We all appreciate all the work you have put in to this as it reads like a whose who of ONCS! Thank you so very much for all you do.
This is a fantastic list! How, exactly do they participate in this organization? It's tempting to put out a mass email to them and see if someone offers a bid!
Well said Regina. I agree. I would love to be able to submit my wife's information, CT scans, etc. to this board as a "tumor board" approach whereby they could confirm existing care and treatment as well as suggest next steps. e.g. We have been told to 1) stay on maintenance chemo for up to one year. We have also been told to 2) start radioembolization within 3 months. Finally, we have been told 3) be patient. Let's see what the next CT scan shows before we talk about next steps.
That's a very broad range of opinions (which is all they are). I'd love to be able to get an evaluation/assessment from a REAL Cholangiocarcinoma Tumor Board, which we appear to have.
The distinguished physicians are in support of the work we doing on behalf of the cholangiocarcinoma patient community. Most have lead or are leading major reserach studies focused on this disease. They will lend their expertise to the numerous projects we are focusing on and support those projects still under consideration or not yet developed.
From what I have learned though is that you can gather 100 experts and you can expect major disagreements amongst physicians and researchers in re: to treatment protocols and options. Hence, for second (or more opinions) you would need to follow the regular channels i.e. make contact through their individual institutions.
Thanks for that Marion, what a great team indeed! Looking forward as well to hearing about the others when they are listed. An absolute ton of experience and knowledge there!
Went to my GI today and told him how he and Dr. Javle look like twins, he said, "they must have used my picture". BTW he told me that he has good feelings about my getting Remicade infusions and I start Sept 20th, yikes. He also told me that when I was so sick in February only 10 inches of my colon was good. Now I only have 1/3 to get better. I did not realize that. Good news as we both feel at my age there would be no more drastic surgery. Cheez that makes me feel old! Hey, if this works watch out....you don't know the old me and I don't mean age wise. Watch out world here I come....again!
I sooo like the sound of his good feelings about your Remicade infusions!! Good news all round there me thinks!
Hi Lainy,
I would always bet on you against anything or anyone!!! so i know the remicade infusions will go well - good luck on 9/20 .
Thank you for this amazing list of experts.
The information expressed is not medical advice. The discussion boards are not intended to replace the services of a trained health professional or to be a substitute for the medical advice of physicians or other healthcare providers. Read the full disclaimer.


text:
Breast Cancer Proteomics and Molecular Heterogeneity
|Tracking Information
|First Received Date ICMJE
|April 23, 2013
|Last Updated Date
|August 9, 2017
|Start Date ICMJE
|February 2013
|Estimated Primary Completion Date
|February 2023 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Investigation of proteins and their pathways in primary breast cancer [ Time Frame: 10 years ]
Investigation of proteins and their pathways in primary breast cancer, which are associated with patient outcome.
|Original Primary Outcome Measures ICMJE
|Same as current
|Change History
|Complete list of historical versions of study NCT01840293 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Same as current
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Breast Cancer Proteomics and Molecular Heterogeneity
|Official Title ICMJE
|Breast Cancer Proteomics and Molecular Heterogeneity
|Brief Summary
Primary objective:
The primary objective is to define the proteomic and molecular characteristics of primary and recurrent/ metastatic breast tumours with special focus on the expression of S100 protein and the estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2) genes
Secondary objective:
|Detailed Description
This is a translational study. Patient will undergo standard treatment and tissue and blood samples will be taken at various time points:
Tissue: Fresh frozen (FF) and Formalin fixed paraffin embedded tissue (FFPE) will be collected at time of surgery/biopsy of a primary or a recurrent/metastatic tumour tissue.
Blood: Two types of study bloods (non-heparinised and Ethylenediaminetetraacetic acid (EDTA)) will be taken pre-neoadjuvant treatment (if applicable), pre- and post-operatively of primary and recurrent/ metastatic breast cancer (if recurrent/metastatic diagnosis and no biopsy/surgery required then study bloods will be taken prior to starting treatment).
Additional blood samples will be taken annually at follow-up visits for 5 years from primary cases and for up to 2 years from recurrent/metastatic cases.
Non-heparinised blood will be processed to serum. Clinical data will be collected at all times of biological sampling.
|Study Type ICMJE
|Study Design ICMJE
|Observational Model: Cohort
Time Perspective: Other
|Target Follow-Up Duration
|Not Provided
|Not Provided
|Sampling Method
|Non-Probability Sample
|Study Population
|All newly diagnosed breast cancer patients, recurrent and stage IV metastatic breast cancer patients.
|Condition ICMJE
|Intervention ICMJE
|Not Provided
|Study Groups/Cohorts
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Estimated Enrollment ICMJE
|Completion Date
|Not Provided
|Estimated Primary Completion Date
|February 2023 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
|18 Years and older (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Listed Location Countries ICMJE
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Cancer Trials Ireland
|Study Sponsor ICMJE
|Cancer Trials Ireland
|Collaborators ICMJE
|Not Provided
|Investigators ICMJE
|Not Provided
|PRS Account
|Cancer Trials Ireland
|Verification Date
|August 2017
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


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Somatic Stem Cells in Endometriosis
Recruitment status was: Active, not recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Other: genetic analysis
|Study Type:
|Study Design:
|Time Perspective: Prospective
|Official Title:
|"Identification, Characterization and Isolation of Somatic Stem Cells in Human Endometrium of Women With Endometriosis"
- Characterization of endometrial stem cells through Flow Citometry and Side Population techniques and In vitro culture cellular proliferation to then characterize the cell population through molecular and cellular techniques. [ Time Frame: TWO YEARS ]
Biospecimen Retention: Samples With DNA
|Estimated Enrollment:
|Study Start Date:
|March 2011
|Estimated Study Completion Date:
|April 2016
|Estimated Primary Completion Date:
|April 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
Other: genetic analysis
Detailed Description:
Throughout the life of the woman, the endometrium undergoes a series of continuous modifications that require a highly accurate feedback mechanism and specialized and must be based on the activity of the stem cell population.
Endometriosis is an estrogen-dependent chronic disease characterized by the presence of functional endometrium outside the uterine cavity, mainly in the peritoneum and ovary (Giudice and Kao, 2004). It affects 6-10% of women of reproductive age, often resulting in a series of gynecological problems, including dysmenorrhea, pelvic pain and infertility. The nature of endometriosis suggests that the initiation of ectopic endometrial lesions may be due to stem or progenitor cells, which is consistent with the theory of retrograde menstruation (Starzinski-Powitz et al. 2001; Leyendecker et al. 2002, Gargett, 2006; Gargett, 2007, Sasson and Taylor, 2008). To date, no direct evidence of the role of somatic stem cells of the endometrium in the pathogenesis of endometriosis. However, numerous studies show that ectopic endometrial cells implant in many established models used for the study of endometriosis.(Masuda et al., 2007b; Sasson and Taylor, 2008; Gargett y Masuda.,2010)
|Ages Eligible for Study:
|20 Years to 40 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
Inclusion criteria for patients with endometriosis:
- Female patients with ovarian endometriosis, peritoneal and recto-vaginal.
- Aged between 20 and 40.
- Signing of informed consent for collection and storage of biological samples.
Exclusion Criteria:
- Contraindications for endometrial biopsy.
- Failure to sign informed consent for collection and storage of biological samples.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01412138
|IVI Valencia
|Valencia, Spain, 46015
|Principal Investigator:
|Carlos Simon, MDPhd
|IVI Valencia
|Responsible Party:
|Carlos Simon, Principal Investigator, Instituto Valenciano de Infertilidad, IVI VALENCIA
|ClinicalTrials.gov Identifier:
|NCT01412138 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 28, 2011
|Last Updated:
|April 21, 2015
Additional relevant MeSH terms:
Genital Diseases, Female
ClinicalTrials.gov processed this record on September 21, 2017


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Posted by susan on September 12th, 2013
Posted in: Library Value, Logic Models, News, Practical Evaluation
The 2nd Edition of the Planning and Evaluating Health Information Outreach Projects series of 3 booklets is now available online:
Getting Started with Community-Based Outreach (Booklet 1)
What's new? More emphasis and background on the value of health information outreach, including its relationship to the Healthy People 2020 Health Communication and Health Information Technology topic areas
Planning Outcomes-Based Outreach Projects (Booklet 2)
What's new? Focus on uses of the logic model planning tool beyond project planning, such as providing approaches to writing proposals and reports.
Collecting and Analyzing Evaluation Data (Booklet 3)
What's new? Step-by-step guide to collecting, analyzing, and assessing the validity (or trustworthiness) of quantitative and qualitative data, using questionnaires and interviews as examples.
These are all available free to NN/LM regional offices and network members. To request printed copies, send an email to firstname.lastname@example.com.
Non-508 compliant pdf versions of all three booklets are available here: http://nnlm.gov/evaluation/guides.html#A2 .
The Planning and Evaluating Health Information Outreach series, by Cynthia Olney and Susan Barnes, supplements and summarizes material in Cathy Burroughs' groundbreaking work from 2000, Measuring the Difference: Guide to Planning and Evaluating Health Information Outreach. Printed copies of Burroughs' book are also available free—just send an email request to firstname.lastname@example.com.


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SWINDON Robins team manager Alun Rossiter cut a disappointed figure as he watched his side slumped to consecutive defeats to Poole Pirates on Good Friday.
The South Coast men also claimed the Elite Shield with an aggregate score of 103-79 as the 47-45 win at the Abbey Stadium added to their 56-34 success earlier in the day.
Robins put in a better display at Blunsdon with skipper Troy Batchelor leading the way with 12 points, while in Poole the Aussie claimed Swindon's solitary heat success following a dominant display from the Pirates.
Rossiter said: "It was a pretty disappointing day all around "Everything went against us, in fairness we were beaten by the better side.
"In the morning we were outclassed and in the evening we were in there fighting.
"We have to get the middle order firing. Simon (Gustafsson) is struggling with engines, I think Nicolai is struggling with confidence."
With concerns over how his team is performing, Rossiter insists that he will not rush into making any changes.
"It is time to gather my thoughts, don't make rash decisions, sit down and think about it all because this was a big blow to us losing," he said.
"Technically we should have won, but it was summed up with Simon (Gustafsson) losing his (steel) shoe in heat 14, he falls off – it is difficult to ride without a steel shoe."
The Robins chief felt that his team should have been able to put the disappointment of the morning meet behind them as they looked to gain revenge from their 22-point loss.
"I think (the defeat) it should have had the opposite affect (psychologically).
"We should have been saying 'we've had a bad morning and now we need to pick ourselves up'.
"I know Simon (Gustafsson) is struggling with engines big style, Nick (Morris) turned it around from the morning, and was just a bit unfortunate with his last race – don't forget he is riding at a tough number there."
The morning meet could not have gone much worse for Swindon as they could only claim success in heat 10, while Pirates were a man down for the majority of the match as Shamek Pawlicki crashed out in heat six and required a trip to the hospital for a CT scan.
The Pirates star was given the all-clear to ride in Swindon and he came back with a 9+1.
But the biggest concern for the Robins is that Klindt after a disappointing 5+1 on the south coast with two seconds and a third could only follow that up with five points in the evening.
Benji Compton, coming in for the unavailable Steve Worrall at Blunsdon, got off to a flying start in Robins colours as he picked up a win and two seconds, however, his fellow reserve Dan Greenwood is struggling with the step up to the Elite League.
Batchelor led the charge for Swindon in both meets, but the Aussie captain will be disappointed that his side were unable to claim victory on a dramatic final heat of the day as Pawlicki came back to beat Peter Kildemand into third and ensure a second win of the day for the Pirates.


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Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
This study has been completed.
Vanda Pharmaceuticals
Information provided by:
Vanda Pharmaceuticals
ClinicalTrials.gov Identifier:
First received: June 22, 2007
Last updated: August 8, 2014
Last verified: August 2014
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.
|Circadian Rhythm Sleep Disorders
|Drug: VEC-162
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
|Official Title:
|A Randomized, Double-blind, Placebo-controlled, Multi-center Study of the Effects of VEC-162 on Circadian Rhythm in Healthy Subjects
Further study details as provided by Vanda Pharmaceuticals:
Primary Outcome Measures:
- Circadian Phase Shift [ Time Frame: Night 3 and Night 4 ]Exposure response to VEC-162 on induction of circadian phase shift as measured by Dim Light Melatonin Onset (DLMO) was defined as the time change between Night 3 and Night 4 when melatonin production reached 25% of the maximum melatonin concentration. Samples below LOQ of the melatonin assay were assigned 5 pg/ml.
- Mean Sleep Efficiency [ Time Frame: Night 4 and Night 2 ]Exposure response was measured by comparing the change in sleep efficiencies of VEC-162 and placebo treated subjects upon a sleep schedule phase advance. Sleep efficiency (total time asleep divided by the time allowed as an opportunity for sleep in a period multiplied by 100%, where time allowed for sleep was 8 hours or 480 minutes) was measured objectively by overnight polysomnographic recordings. Sleep efficiency was also compared in parts of the night by dividing the full night into thirds.
Secondary Outcome Measures:
- Wake After Sleep Onset (WASO), and Latency to Persistent Sleep (LPS) [ Time Frame: Night 2 and Night 4 ]
Wake After Sleep Onset is defined as the total time that is scored as awake in a PSG occurring between sleep onset and lights-on prompt.
Latency to Persistent Sleep is defined as the number of epochs (one 30-second interval of the sleep episode) from the beginning of the recording (lights-out) to the start of persistent sleep (first 20 consecutive non-wake state) divided by 2.
- VEC-162 AUC [ Time Frame: Night 4 ]
- VEC-162 Cmax [ Time Frame: Night 4 ]
- VEC-162 Tmax [ Time Frame: Night 4 ]
|Study Start Date:
|July 2004
|Study Completion Date:
|March 2005
|Primary Completion Date:
|March 2005 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|18 Years to 50 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- No medical, psychiatric, or sleep disorders
- Ability to provide written informed consent
Exclusion Criteria:
- Lifetime history of night shift work
- Evidence of any sleep disorder
- Psychiatric or neurological disorders
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00490945
Please refer to this study by its ClinicalTrials.gov identifier: NCT00490945
|United States, Massachusetts
|Vanda Investigational Site
|Boston, Massachusetts, United States
|United States, Michigan
|Vanda Investigational Site
|Detroit, Michigan, United States
Sponsors and Collaborators
Vanda Pharmaceuticals
|Study Director:
|Marlene Dressman, PhD
|Vanda Pharmaceuticals Inc
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 20, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB. Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet. 2009 Feb 7;373(9662):482-91. doi: 10.1016/S0140-6736(08)61812-7. Epub 2008 Dec 4. Erratum in: Lancet. 2009 Apr 11;373(9671):1252.
|ClinicalTrials.gov Identifier:
|NCT00490945 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 22, 2007
|Results First Received:
|February 28, 2014
|Last Updated:
|August 8, 2014
Additional relevant MeSH terms:
Sleep Wake Disorders
Sleep Disorders, Circadian Rhythm
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders
Chronobiology Disorders
Occupational Diseases
ClinicalTrials.gov processed this record on September 20, 2017


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When it comes to cartoons, both adults and children alike smile at those loveable characters. From friendly Mickey Mouse to easily provoked Donald Duck to daydreaming Snoopy and a cute Hello Kitty, excitement grows when being presented with cartoon character gifts.
Cartoon costumes for girls
Girls like to take on a cartoon character as a persona, especially the famous Sleeping Beauty, Snow White and Cinderella. Not only is it a kind of cute thing to see girls dressed in costumes and role playing but, parents like presenting their girls with these costumes in order to see their faces surprisingly glowing. Read More


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COMMUNITY causes and charities across have been given a cash boost by Brierley Hill Area Committee.
At last night's meeting (Thursday) at The Brier School, Kingswinford, councillors were told groups across the Brierley Hill and Kingswinford area have received a slice of £20,672 of Dudley Council cash since the last meeting.
St Mary's Church Centre, Kingswinford, was given £5,768 to improve facilities including disabled access.
Wordsley Community Association collected £5,370 to buy new computer equipment and to upgrade the flooring at the centre at The Green.
Fens Pool Voluntary Association in Brierley Hill was given £2,164 for furniture and various items of kitchen equipment.
Enlight Projects scooped £2,370 towards buying new equipment to support the work of the group at Saltwells and High Oak Youth Clubs.
And Top Church Training netted £5,000 to support the project worker's salary for one year and to finance administration costs to set up a young people's allowance fund.
In addition - it was also agreed at last night's meeting to approve grants of £5,000 to 2156 (Brierley Hill) Squadron, Air Training Corps, to buy first aid, IT and adventure training equipment; and to Insight Carers towards refurbishment work at its premises in Pearson Street, Brierley Hill.
Age UK was also awarded £1,480 towards IT equipment at the charity's Netherton office.
The committee also agreed in principle to approve hand outs of £3,512 for the purchase and installation of four Christmas trees in the committee area; £5,000 to the Wordsley Festival committee towards the 2012 festival and associated events; and to give £5,000 to The Samaritans for a new CCTV security system, to improve security lighting and to provide a secure door entry system.


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This effect takes a couple of classic principles of mentalism and melds them into an entirely new routine designed to bring jaw-dropping awe and admiration to all who witness it!
A participant freely thinks of a number of thoughts, such as words or dates. The performer writes something down on a business card and seals it up inside a small envelope. To make it even more challenging, the participant is instructed to focus on just one of those thoughts. The choice is randomly chosen.
The participant removes the business card form the sealed envelope and finds the freely chose though written in the message on the back. And, of course, this business card can be given away as a perfect and unforgettable souvenir of the performer's incredible abilities!
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text:
Also available as CD / Download
Now also available iPhone 4/4s app to view the animations! Fonal Strobe app Watch this video to see how it works!
A1. Vinonaamakasio2. Mulberg3. Riddarholmen4. Fuzzabeth Crackleby5. Holvikirkko
B6. Corda7. Svileto8. Ratalintu9. Nebulus
With their second album Shogun Kunitoki expand the boundaries of their self-created sonic universe with a wider array of sounds and rhythms. Where their debut, Tasankokaiku, squeezed cosmic dust into fiery balls of molten lava with gravitational push and pull and followed the planets whirring through the void on looping trajectories, Vinonaamakasio zooms in to explore the surface of newfound heavenly bodies, outlines the jagged shapes of exploding volcanoes, rolls with the moonlit waves through the cracks of sleeping, phosphorescent coral reefs, and marches in step with the six-legged insect armies making their trails through the steaming jungle. Every atom of this newborn planet of sound vibrates synchronous to the seething psychedelic stew that throbs under the surface and burns your feet if you let them stop moving.
For those looking for the ultimate psychedelic experience, this Picture LP features two animation loops that can be viewed using the Magical Shogun Kunitoki Strobe Light. Please note you need both the Picture vinyl and the strobe light to see the animations.
Format: LPTotal lenght: 35 minutesCatalogue Number: FR-62LPRelease date: Finland 11.3.2009 Wordwide 18.3.2009
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Hosted by Woima


text:
Gamble on De Oca doesn't pay off for White Sox
CHICAGO -- The White Sox signed 30 of their first 31 picks from the 2014 First-Year Player Draft, missing only on Bryce Montes De Oca. The 6-foot-7, 265-pound right-hander was selected in the 14th round and probably fell that far despite his mid-90s fastball because of his reconstructed elbow.
De Oca, an 18-year-old taken out of Lawrence High School in Kansas, also had a scholarship from the University of Missouri.
"We knew that would be a tough sign," said White Sox general manager Rick Hahn. "He's probably a name we are going to hear about again in three years, if he is able to fulfill his potential. It was a worthwhile gamble, but we knew it was a long shot to sign him."
With Carlos Rodon, the team's top pick and third selection overall, receiving a franchise-record $6.582 million signing bonus, the White Sox spent around $10.5 million on this year's Draft and exceeded their bonus pool. They incurred a tax for the first time of $356,175 but were happy with the overall talent they added to the organization.
Scott Merkin is a reporter for MLB.com. Read his blog, Merk's Works, and follow him on Twitter @scottmerkin. This story was not subject to the approval of Major League Baseball or its clubs.


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Jim Schirmer
Jim Schirmer
Jim Schirmer grew up in Saginaw, Michigan, and moved to Columbia in 1988 to attend seminary at CIU. He joined the CIU team as a seminary faculty assistant in 1990 and is now a faculty assistant for the Center for Educational Innovation and Development. As a faculty assistant, Jim works diligently to help students with their online courses and answer any questions that they have…which are quite common! When Jim is not tirelessly grading students' work or responding to countless frantic emails, he pastors Heritage Presbyterian Church in West Columbia and also likes to play tennis and volleyball with friends and family. Jim and his wife Ann have five sons—four of whom are adopted—and know that God has called them to disciple the next generation. Jim's heart for students and devotion to the Lord make an incredible impact not only here at CIU but everywhere God uses him.
Fun Facts!
Education: B.A. from Anderson University, M. Div. & M.A. from CIU, D. Min. from Reformed Theological Seminary
What he'd do with $1,000: buy some new books, a new bookcase, and a new tennis racket
Best part of waking up: reading Scripture and praying
Aspiration: write a book on discipleship in the family, learn a foreign language


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CHANDIGARH:In a major development in the 10-year-old's rape case, the UT police today arrested the second accused in the case, younger brother of accused Kul Bahadur who was arrested earlier by the police for raping the minor.
NEW YORK: Actor Priyanka Chopra said that global leaders need to come together to create a better, brave and safe new world.
BN Goswamy
Satire. noun