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Duck softball splits pair in Fresno
FRESNO, Calif. - The No. 8 University of Oregon softball team (21-4) capped play in the Fresno State Classic with a 4-2 win over St. Mary's and 2-1 loss to Iowa State Saturday at Bulldog Stadium.
In the tourney finale, the Ducks staked their 20th win all-time vs. the Gaels (4-13), thanks to their single runs in the first, second, fourth and sixth innings.
St. Mary staked an early lead with a run in the top of the first inning, and scored once more in the fifth inning.
The Ducks' opening three hitters all rapped multiple hits - junior shortstop Courtney Ceo (2-for-4), sophomore center fielder Janie Takeda (3-for-4, 1 RBI) and senior second baseman Kaylan Howard (2-for-3, 2 RBI).
In the first inning, freshman third baseman Koral Costa knocked in her second game-winning RBI of the season, thanks to her bases-loaded walk.
Takeda knocked in the next run in the second inning on a single, as did Howard in both the fourth and sixth innings.
Four other Ducks hit safely once.
In her sixth start of the campaign, sophomore Karissa Hovinga pitched 3.1 innings, struck out one, walked none, gave up six hits, and her run allowed was earned.
Freshman Cheridan Hawkins (7-1) relieved her in the fourth inning, and in her 3.2 innings, logged five strikeouts, no walks, two hits, and her run allowed was earned.
For St. Mary's, Sarah Lira (0-5) pitched all six innings, struck out one, walked two, allowed 11 hits, and two of her four runs allowed were earned.
Three Gaels had multi-hits - Brittany Sabatini (2-for-4), Megan Smith (2-for-3, RBI) and Andrea Hazel (2-for-3).
Earlier in the weekend, UO beat returning Mountain West champion San Diego State (3-2) on Friday, and lost to Iowa State (2-1) on Saturday.
Oregon was also slated to play host Fresno State Friday night, but after taking a 5-1 lead into the bottom of the second, an hour rain delay led to the contest being cancelled.
In UO's first meeting with Iowa State since 2004 (and third ever), the Ducks saw their 13-game win streak come to an end in the 2-1 decision.
The two teams were scoreless through the fifth inning, before UO scored its lone run in the sixth.
Junior shortstop Courtney Ceo led off with a single up the middle, and after a fly ball to right field marked the second out, she tagged and beat the throw to second base. Three pitches later, she easily scored on a single up the middle by sophomore Janie Takeda.
UO nearly tied the game in the seventh, when after two outs, freshman left fielder Danica Mercado and senior right fielder Samantha Pappas walked to put runners on first and second base.
Ceo drilled a hard grounder down the first base line that the first baseman lunged and barely nabbed, then touched the bag to end the game.
For the game, Ceo (3-for-4) led UO in hits with her 11th multi-hit game of the season and tied her career high for hits in a game.
Takeda (2-for-3) also collected multiple hits, and Pappas (1-for-4) also singled safely once.
Junior first Kailee Cuico saw her team-high 18-game hitting streak come to an end with her 0-for-3 day after she grounded out once and flew out twice.
Takeda now owns the team's longest current hitting streak - a 10-game streak - and Ceo is one behind her (9).
Senior Jessica Moore (11-3) pitched the first 5.2 innings, struck out three, walked two, allowed eight hits, and both of her runs allowed were earned.
Iowa State scored both of its runs in the sixth inning, and still had the bases loaded with two outs. Freshman Cheridan Hawkins was called in and notched a strikeout of the Cyclone's #2 hitter Brittany Gomez to end the inning.
Earlier in the inning, the Cyclones laced pair of singles among the first three at-bats, and a hit by pitch loaded the bases. The next batter, Lexi Slater singled home the first run, and a fielder's choice grounder by Maddie Reese to the shortstop scored the next run.
Iowa State starter Tori Torrescano (5-3) pitched the complete game, struck out four, walked two, allowed six hits, and her run allowed was earned.
Overall for the three completed games, Takeda led UO in batting (.636), hits (7) and stolen bases (2).
Ceo also eclipsed .500 for the trip (.545, 6H, RBI, SB), and three others also topped .300 - Howard (.375, 3H, 2 BB, 3 RBI), Lindvall (.333, 2H) and junior catcher Alexa Peterson (.333, 2H).
Howard also made her debut on the Duck all-time career RBI list (10th, 117), and tied former great Kathy Stahl.
In the circle, senior Jessica Moore (1-1) led the team in ERA (1.40), innings (10) and strikeouts (7).
UO's other pitching stats follow: Hovinga (2.10, 0-0, 3.1 IP, 1 SO, 6H, 1 ER), Hawkins (3.15, 1-0, 6.2 IP, 6 SO, 3 BB, 4H, 3 ER).
Looking ahead, UO returns to Eugene for its home opener Wednesday vs. New Mexico. The doubleheader starts at 2 p.m. at Howe Field, and various St. Patrick's Day promotions will take place.
Like all Duck softball doubleheaders, fans only have to pay a single-game ticket price to enjoy both games.
#9 Oregon 4, St. Marys 2 (Mar 09, 2013 at Fresno, Calif.)
St. Marys 100 010 0 - 2 8 1 (4-13)
#9 Oregon 110 101 X - 4 11 0 (21-4)
Pitchers: St. Marys - LIRA, S. and HAZEL, A.. Oregon - Hovinga, Karissa; Hawkins, Cheridan(4) and Lindvall, Janelle. Win-Hawkins, Cheridan(7-1) Loss-LIRA, S.(0-5) T-1:35 A-300. Weather: 57 cloudy wind 5-10 MPH
Iowa State 2, #8 Oregon 1 (Mar 09, 2013 at Fresno, Calif.)
#8 Oregon 000 001 0 - 1 6 1 (20-4)
Iowa State 000 002 X - 2 8 1 (10-9)
Pitchers: Oregon - Moore, Jessica; Hawkins, Cheridan(6) and Peterson, Alexa. Iowa State - Torrescano and Davison. Win-Torrescano(5-3) Loss-Moore, Jessica(11-3) T-1:55 A-250. Weather: 50 Mostly Cloudy, Wind 5-10MPH


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The nightmare scenario for Indiana, the one that seemed inconceivable about a week ago, took another improbable step toward unfolding on Tuesday night when the second-ranked Hoosiers were upended at home by No. 14 Ohio State, 67-58, on Senior Night at Assembly Hall.
The Hoosiers all but had a No. 1 seed for the NCAA Tournament wrapped up when they started play last week, and they were the odds-on favorite to land the No. 1 overall seed. That designation—which means that they would be placed as close to home as possible for the length of their NCAA Tournament run—is more important to the Hoosiers than any other team in the country.
It just so happens that one of the four regional sites—where the Sweet 16 and Elite 8 games are played—is in Indianapolis, a short drive from Bloomington. The possibility of this Indiana team losing a game in front of 70,000 hometown fans at Lucas Oil Stadium with a Final Four berth on the line seems remote.
But last Tuesday, the Hoosiers lost at Minnesota. In a vacuum, that's not a big deal. The Gophers are very good, especially at home, and Indiana retained the No. 1 overall seed in this week's Field of 68 projection on Monday. But now, the Hoosiers have unexpectedly dropped another game, at home against a Buckeyes team they handled easily on the road.
Again, by itself, that's not horrible. It's worse than the loss at Minnesota, true, but Ohio State is another very good team. Add in that to the defeat to the Gophers, though, and all of a sudden that grip on the No. 1 overall seed might be gone—Duke is charging hard, with Ryan Kelly now back on the court and playing well. And, Indiana's lone remaining regular-season contest might be its most difficult of the year.
The Hoosiers have to play at Michigan on Sunday. The Wolverines haven't lost at home all season, and that includes wins against Michigan State, Ohio State, N.C. State, Minnesota and Illinois. If the Hoosiers lose that one, they'll have five Big Ten losses and will almost certainly share the regular-season title—which they could have clinched outright Tuesday with a victory—with at least one other team and possibly as many as three others.
And if that happens, Indiana could easily fall off the No. 1 seed line in the NCAA Tournament, if they fail to win the Big Ten Tournament. If they fail to at least reach the league championship game, they would certainly fall off the top line.
And if they lose their spot on the top seed line, they might not land the Indianapolis regional. It's not often that championship-caliber teams have the opportunity to have that kind of home-court advantage; to let that slip away would be a giant waste.
If Michigan beats Indiana and winds up with a No. 1 seed and the Hoosiers finish on the second seed line, the Selection Committee would put the Wolverines in the Indianapolis region—it's much closer for them than Los Angeles, Arlington (Texas) or Washington, D.C. So the Hoosiers would be shipped out to one of the other three regions—bracketing rules dictate that the top three teams from every conference be placed in different regions.
Now, let's be clear. This Indiana team still is talented enough to win the national championship from any region. And there are several steps that still have to play out for the Hoosiers to drop to a No. 2 or 3 seed—not just Indiana losing games, but other teams (Miami, Michigan, Kansas, Georgetown, Gonzaga, etc.) winning conference tournaments.
But all of a sudden those aren't just one-in-a-million chances. These two losses, along with an imposing schedule the next two weeks, make it a real possibility.

subset: commoncrawl


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for the years of love with VailPM.
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On two lunchtime visits, the place was packed but the second visit almost turned into an epic fail, as the kids would say. You see, after my lunch guests and I got through the line and paid, we were left holding our trays with no place to sit.
There was one empty table, but much to my chagrin, as I approached I discovered two people in line had thrown their coats on the seats to save the booth.
Tempted as I was to cast their coats aside and take their table, instead I stood in the middle of the restaurant and wailed rather loudly, "there's no place to sit!"
And then two very kind women who were done eating hopped up and let us take their booth. Problem solved.
Salsa Grille is set up much like a Moe's Southwest Grill or Chipotle or Qdoba. You go down a line and order your food, customizing what you want on your tacos or in your burrito or bowl. Pay at the end, serve yourself a drink from the soda fountain and then find one of those elusive tables.
The restaurant is bright and sunny, clean and new with a modern, attractive look. It even has some shelves with cans and staples from George's for sale, and a refrigerator case with cheese, sour cream, wraps and more.
It's not a place to go if you're not quick to make decisions. You have to decide what type of entree you want and then what you want in it. You don't feel as if you can dally, especially when a line stretched behind you.
The first choice you have to make is if you want three tacos, a burrito, quesadilla, nachos, taco salad or a bowl. Then you decide your meat, rice, beans and toppings.
I chose the three toppings, and the servers were generous with the fillings. I had Spanish rice and black beans, chicken on two and ground beef on one, and assorted toppings.
My lunch guests both chose the low-carb option: bowls, which were filled with rice, beans, chili and toppings.
When you pay, you're handed a basket of tortilla chips. After you pay, you proceed to the salsa bar, where you can choose from about eight different types of salsa. Then you get your drinks, and then find a seat.
We all were impressed with the food at Salsa Grille. The ingredients seemed fresh, the meat was tender and nicely seasoned, and the assortment of salsas gives your dish as much or as little heat as you like. My favorite topping was the fresh cilantro on my tacos. Speaking of cilantro, it also was used generously in the mild salsa.
I tried a couple other salsas. I very much liked the mild fresh tomatilla salsa. However, I didn't care for the avocado salsa, which looked and tasted like pureed avocado.
Salsa Grille's queso dip also was a hit on my first visit. It was made with white cheese and mild spices. My only complaint is that it had started to congeal on top, and some of that sticky stuff was poured into our container.
Both experiences were good at Salsa Grille. It's nice to be able to customize your food. As for the shortage of tables, I did talk to Chris Rongos about that. He said they wish they had more space for tables.
If you want a leisurely sit-down meal, Salsa Grille probably isn't the place to go. But if you want good Mexican food, reasonably priced, give it a try.
But please, if the place is full, don't claim the last table available when you're still in line. It's not fair to the others who are wandering around with full trays, looking for a place to eat.
Instead, just stand in the middle of the room with your tray, looking pathetic. I guarantee you somebody who has finished their meal will take pity on you, get up and give you their seat.
Every other Tuesday, Cindy Larson describes a one-time dining experience at an area restaurant. The News-Sentinel pays for meals. This column is the personal opinion of the writer and does not necessarily reflect the views or opinion of The News-Sentinel. You can reach her at 461-8284 or firstname.lastname@example.com. To read other columns, go to www.news-sentinel.com/section/LARSON.
More Information
Salsa GrilleAddress: 7755 Coldwater Road
Phone: 755-6905
Hours: 11 a.m.-9 p.m. Monday-Thursday; 11 a.m.-10 p.m. Friday-Saturday; and 11 a.m.-8 p.m. Sunday
Alcohol served? Yes
Credit cards accepted? Yes
Menu sampler:
You order your entree as three tacos, a burrito, quesadilla, nachos, taco salad or a bowl. Prices are based on the meat you choose:
•Ancho chili chicken (marinated in anco chile sauce), $6.25
•Carne asada (grilled skirt steak with cilantro, garlic and oregano marinade), $6.55
•Verde chicken chimichurri (shredded chicken tossed with fresh herbs, vinegar and olive oil), $6.55
•House chorizo sausage (pork sausage with smoked chiles and smoked paprika), $6.25
•Pork carnitas (slow cooked with spices), $6.55
•Carne molido (ground beef with seven spices), $6.25
•Barbacoa (chuck steak with serrano chiles and red wine), $6.55
•Queso dip (jack cheese with roasted poblano peppers and spices), $2.95
•Amarillo rice (yellow with sweet onion, tomato, traditional spices). $1.50
•Tortilla soup, $4.50
•Guacamole, $1.50
•White sweet corn rice, $1.50
•Pinto beans, $3
•Black beans, $3
Kids' menu:
•Cheese quesadilla, $3.25
•Chicken taco, $3.50
•Cheese/rice burrito, $3.25


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This year's New York Produce Show will feature a number of educational sessions and retail tours.
The show is also attracting increased interest from chefs and students considering entering the industry.
In a Dec. 10 global trade symposium, participants can learn about New York's role in world produce shipments by attending "Produce Import/Export: A View from America's Gateway to the World."
On Dec. 11, before the start of the expo at Pier 94 on 54th Street and West Side Highway, a keynote breakfast includes a retail panel featuring vice presidents from leading Northeastern retail chains.
The session includes an expanded panel of buyers, said Eastern Produce Council president Paul Kneeland, vice president of produce and floral, seafood and meat for the Parsippany, N.J.-based Kings Super Markets LLC.
The panelists:
- Kneeland;
- Eric Beelitz, Montvale, N.J.-based The Great Atlantic & Pacific Tea Co.;
- Marc Goldman, Morton Williams Supermarkets, New York;
- Derrick Jenkins, Wakefern Food Corp., Keasbey, N.J.;
- Vic Savanello, Allegiance Retail Services LLC, Iselin, N.J.;
- Eric Stone, FreshDirect Inc., Long Island City, N.Y.;
- Steve Wright, Tops Markets LLC, Williamsville, N.Y.; and
- Tony Mirack of McCaffrey's Markets, Langhorne, Pa.
Chef demonstrations are also scheduled for the day as well as other educational sessions.
On Dec. 12, buses are scheduled to take visitors on five daylong tours of retail operations in Manhattan, Brooklyn and New Jersey as well as to the Hunts Point Terminal Market and Philadelphia Wholesale Produce Market.
The Brooklyn itinerary includes a tour of an urban agricultural operation while the New Jersey retail tour features a visit to a tofu manufacturing plant as well as a visit to a newly branded Kings store in Gillette, N.J., Kneeland said.
The bus traveling to the Philadelphia market also plans to visit a Wegmans Food Markets store, he said.
New this year, a retailer from China is expected to participate in the show and join a representative from the United Kingdom's Marks & Spencers chain, Kneeland said.
Also scheduled for that day is Ideation Fresh, a foodservice forum featuring some leading Northeastern chefs.
"The global symposium is certainly a draw to people outside of this country, but also to those here that want to do business globally," Kneeland said.
"The foodservice symposium is also very strong. It attracts students from the Culinary Institute of America and the French Culinary Institute of America. The forums have really been a huge enhancement for us. We feel this show is very strong as it's attracting people from all over the world."
Additionally, students from eight leading Northeastern universities are planning to participate in the show, more than last year, said John McAleavey, the Short Hills, N.J.-based council's executive director.
The students plan to walk the show floor with a council director and meet with different produce companies, he said.
Kneeland said the two student programs, which cover the produce and culinary industries, provide opportunities for young people to interact with industry leaders during the convention's panels.
The programs also offer guidance on produce industry careers.
"They learn the industry's not very small like a lot of people see it from the retail side," he said.
"By seeing how large this industry really is, these students gain a lot of knowledge and see how they can really find their niche in it."
Convention organizers are also scheduling a spouse/companion program.
The event allows participants to spend more time with their families enjoying New York during the holiday season, Kneeland said.


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- Wells Fargo (WFC) saw its pre-provision net revenue -- backing out gains on equity investments and gains on debt securities available for sale -- grow 13% year-over-year, to $9.1 billion in the third quarter, according to Thomson Reuters Bank insight. While third-quarter tax-adjusted net interest income declined to $10.10.820 million from $10.714 million a year earlier, noninterest income rose to $10.384 billion from $8.442 billion, and noninterest expense declined by over $1 billion to $12.112 billion. Mortgage banking revenue was up 53% year-over-year to $2.807 billion in the third quarter, while the company reported net gains from trading activities of $529 million, compared to losses of $442 million, a year earlier. Overall earnings performance remained strong, with a third-quarter ROA of 1.45% and a return on equity of 13.38%.
- For JPMorgan Chase (JPM), pre-provision net income increased 14% year-over-year to $10.317 billion. The company's tax-adjusted net interest income declined to $11.176 billion in the third quarter from $11.950 billion a year earlier, as the company's net yield narrowed by 23 basis points year-over-year, to 2.43%. But the company's third-quarter noninterest income -- backing our securities gains -- increased to $13.712 billion from $11.339 billion in the third quarter of 2011. JPMorgan's Corporate/Private Equity business line saw profit increasing to $221 million in the third quarter, from a loss of $645 million a year earlier. Meanwhile, Retail Financial Services profit grew 21% year-over-year, to $1.408 billion, amid the wave of mortgage loan refinancing.
- Citigroup (C) saw a 22% year-over-year decline in pre-provision net revenue, to $5.887 billion in the third quarter. Third-quarter tax-adjusted net interest income declined to $12.054 billion from $12.252 billion a year earlier, reflecting a decline in earning assets, as part of the company's long-term strategy to right-size its balance sheet. Citi's net interest margin actually expanded, to 2.86% in the third quarter, from 2.83% a year earlier. Noninterest income declined to $6.237 billion in the third quarter from $8.098 million a year earlier. The third-quarter bottom-line results included a pre-tax loss of $4.7 billion from the sale of a 14% interest in the Morgan Stanley Smith Barney joint venture and the write-down on Citi's remaining 35% interest in the joint venture, which will eventually be sold to Morgan Stanley (MS). A major positive for Citigroup an estimated Basel III Tier 1 common equity ratio was strong 8.6% as of Sept. 30, giving investors hope that the company could receive Federal Reserve approval for a significant return of capital during 2013.
- For Bank of America (BAC), one-time items brought the company's third-quarter pre-provision net revenue down by 55% year-over-year, to $4.380 billion in the third quarter. Third-quarter results included pretax litigation expenses totaling $1.6 billion, including the settlement of a 2009 class action lawsuit, related to the company's acquisition of Merrill Lynch. Bank of America's net interest income declined to a tax-adjusted $10.167 billion in the third quarter, from $10.739 billion a year earlier. Noninterest income was down 36% year-over-year, to $10.157 billion in the third quarter, in part because the third-quarter 2011 results included a $3.6 billion gain on sales of shares in China Construction Bank, which was partially offset by a loss of $2.2 billion on private equity and other investments, including the CCB stake.
NEW YORK ( TheStreet) -- Yes, it was a difficult third-quarter bank earnings season, and the fourth-quarter is expected to be even worse.However, many banks have grown their earnings considerably over the past few years. Two of the main challenges to the industry have been widely covered. First is the pressure on the net interest margin, which is the difference between a bank's average yield on loans and investments and its average cost for deposits and borrowings. With the Federal Reserve keeping its target federal funds rate in a range of zero to 0.25% since the end of 2008, most banks have already seen all the benefit on the interest expense side that they are likely to see. Meanwhile, the central bank in September expanded its purchases of long-term mortgage-backed securities by $40 billion a month -- known as QE3 -- in an attempt to push long-term rates lower, or at least keep them at their historically low levels. Banks are also expected to see a sharp decline in commercial and industrial loan origination during the fourth quarter. Before this year's boom in residential loan refinancing, C&I lending was a bright spot for the industry. FBR analyst Paul Miller said last week that commercial borrowers are entering into new agreements for bank credit lines, but "but they are not borrowing the money," as they keep their expansion powder dry and wait for the election results and for Congress to compromise on the "fiscal cliff." The fiscal cliff could cause the income tax cuts -- including the 15% maximum tax rate on qualified dividends -- signed into law by President George W. Bush and extended by President Obama in 2010, to expire as part of the 2010 budget compromise. Unless a fiscal cliff deal is worked out, there will be mandatory federal spending cuts, along with the tax increases, which the Congressional Budget Office and many economists think will send the U.S. economy back into recession. Moving past the gloom and doom, many banks grew their earnings sequentially and year-over-year during the third quarter, and not just from credit quality improvement and the release of loan loss reserves. Banks typically add to their loan loss reserves each quarter, which is called the "provision" for reserves. If the provision is negative, or if it is less than the dollar amount of loans charged-off during the quarter, the bank has "released" reserves. In order to keep banks from "managing" their earnings by manipulating their quarterly provisions for reserves when credit quality is strong, regulators frown on banks "over-reserving" during the good times, and may even force banks to over-reserve during an economic downturn. With the general improvement in credit quality as we move through the slow economic recovery, most large banks have been seeing quite an earnings boost from the release of loan loss reserves over the past two years. Using the partial set of third-quarter data that is now available , we have identified five banks that have significantly grown their pre-provision net revenue. Pre-provision net revenue is calculated by adding a bank's net interest income -- tax-adjusted if possible -- to its non-interest income, and subtracting its noninterest expense. Using this approach can lead to some rather extreme results, with one-time items affecting one quarter's earnings, so we have narrowed the sample to include only companies that were profitable, with positive operating returns on average assets (ROA) for the past five quarters, and companies that also saw their pre-provision net revenue grow quarter-over-quarter. Two of the "big four" U.S. banks have seen their pre-provision net revenue grow significantly over the past year:


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"Guidelines and Recommendations in Drug Treatment"
Conference, Nicosia, 11-13 May 2009
The Pompidou Group in cooperation with the Cyprus Antidrugs Council held a conference on Guidelines and Recommendations in Drug Treatment in Nicosia, Cyprus on 11-13 May 2009. Over 100 participants from 21 European countries tried to tackle the issue of how to bridge the gap between clinical practice and evidence-based practice in drug treatment. The conference offered direct insights in to how guidelines and recommendations on drugs treatment are developed and implemented in Europe.
Final Abstracts
Photo gallery of the Conference


text: I guess I haven't watched them that closely. I just know they've been playing good ball as of late and they beat us up pretty good too. I just said he should be a candidate, but I'm almost positive it'll be a western coach, Terry Stotts maybe?This quote is hidden because you are ignoring this member. Show Quote


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Historical society offers docent-led tours
October 11, 2012
The Lake Tahoe Historical Society will offer three docent-led tours of the historic Al Tahoe neighborhood.
LTHS sold out the self-guided walking tour guides of the Historic Al Tahoe neighborhood and has decided to offer docent-led tours with expanded stories of the past. Tours will be offered Oct. 13, Oct. 27 and Nov. 3. Tours will leave the museum at 1 p.m. with historian Lee Vestal. Groups are limited to 10 and reservations may be made at email@example.com. A tax-deductable $5 donation is requested.


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Safety and Efficacy of Marqibo in Metastatic Malignant Uveal Melanoma
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Marqibo (liposomal vincristine) is a form of vincristine preparation. Vincristine is designed to interfere with the multiplication of cancer cells, which may slow or stop their growing and spreading throughout the body. This may cause the cancer cells to die. Liposomal vincristine is formed when vincristine is placed inside of oil droplets called liposomes, which may help to improve the delivery of drug to the tumor site. The liposomal formulation results in a slow, steady release of vincristine in the tumor metastasis, exposing the cancer cells to vincristine continuously.
The goal of this clinical research study is to learn if Marqibo (liposomal vincristine) can help to control metastatic uveal melanoma. The safety of liposomal vincristine will also be studied.
Approximately 50 patients will take part in this study.
|Metastatic Malignant Uveal Melanoma
|Drug: Marqibo® (vincristine sulfate liposomes injection)
|Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase 2 Study of Marqibo in Patients With Metastatic Uveal Melanoma
- Overall response rate. [ Time Frame: Every 6 weeks ]
|Study Start Date:
|November 2007
|Study Completion Date:
|December 2014
|Primary Completion Date:
|December 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Cohort 1
Cohort 1 subjects will receive MARQIBO at a dose of 2.25 mg/m2 IV over 1 hour every 2 weeks.
Drug: Marqibo® (vincristine sulfate liposomes injection)
Cohort 1 subjects will receive MARQIBO at a dose of 2.25 mg/m2 IV over 1 hour every 2 weeks.
Cohort 2 subjects will receive MARQIBO at a dose of 2.25 mg/m2 IV over 1 hour every week.
Experimental: Cohort 2
Cohort 2 subjects will receive MARQIBO at a dose of 2.25 mg/m2 IV over 1 hour every week
Drug: Marqibo® (vincristine sulfate liposomes injection)
Cohort 1 subjects will receive MARQIBO at a dose of 2.25 mg/m2 IV over 1 hour every 2 weeks.
Cohort 2 subjects will receive MARQIBO at a dose of 2.25 mg/m2 IV over 1 hour every week.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Uveal melanoma with histologic or cytologic confirmation of metastatic disease.
- One unidimensionally measurable lesion. If this is a cutaneous lesion it must be at least 10 mm by caliper measure. If it is a visceral or nodal or soft tissue lesion, it must be >20 mm with conventional techniques or >10 mm with spiral CT scan. Bone lesions are not considered measurable.
- Must not have received any prior systemic chemotherapy, immunotherapy, vaccine or hepatic arterial chemotherapy for metastatic disease.
- Adequate liver, renal, and bone marrow function.
- Zubrod performance status of 0-2.
- Sign an informed consent form.
Exclusion Criteria:
- Major surgery within 4 weeks of enrollment.
- Advanced symptomatic central nervous system (CNS) involvement by melanoma and those on phenytoin or requiring steroids for brain metastases, spinal cord compression, or meningeal "carcinomatosis".
- History of neurological disorders unrelated to chemotherapy (including familial neurological diseases and acquired demyelinating disorders).
- Grade 2 or greater sensory, motor and/or autonomic neuropathy at screening from any cause.
- Receiving treatment with drugs known to inhibit or induce hepatic drug metabolism by cytochrome P450-3A4 isoenzymes and/or P-glycoprotein within 1 week of study enrollment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00506142
|United States, California
|University of California, Los Angeles
|Los Angeles, California, United States, 90024
|United States, Colorado
|University of Colorado, Denver
|Denver, Colorado, United States, 80045
|United States, Pennsylvania
|Thomas Jefferson University
|Philadelphia, Pennsylvania, United States, 19107
|United States, Texas
|University of Texas M.D. Anderson Cancer Center
|Houston, Texas, United States, 77030
|Principal Investigator:
|Deborah Sanders, MD
|MD Anderson
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Spectrum Pharmaceuticals, Inc
|ClinicalTrials.gov Identifier:
|NCT00506142 History of Changes
|Other Study ID Numbers:
HBS408 (formerly IST401)
|Study First Received:
|July 23, 2007
|Last Updated:
|June 2, 2015
Additional relevant MeSH terms:
Uveal Neoplasms
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Nevi and Melanomas
Eye Neoplasms
Neoplasms by Site
Eye Diseases
Uveal Diseases
Antineoplastic Agents, Phytogenic
Antineoplastic Agents
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 21, 2017


text: Patriot plan short on health-care fund, UMW says By Ken Ward Jr. February 2, 2013 Story Share CHARLESTON, W.Va. -- A plan proposed by bankrupt Patriot Coal would provide only half of the money needed to fund health-care benefits for thousands of retired coal miners and their families, according to new court documents filed by the United Mine Workers union.As part of its financial restructuring, Patriot wants to set up a new, separate trust, called a voluntary employee beneficiary association, or VEBA, to fund health-care benefits for retirees, UMW lawyers say.Patriot has proposed putting $15 million into the fund on June 1, and then setting up a profit-sharing mechanism equal to 15 percent of the company's annual net income.But, the UMW says, Patriot proposes to cap its annual contribution at $40 million and its total contribution at $200 million.By contrast, retiree health-care benefits cost Patriot $71 million in 2012, and the figure is expected to increase to nearly $74 million this year.The disclosure of the proposal is the first time that details have been made public about Patriot's closed-door discussions with UMW negotiators about how the St. Louis-based coal giant plans to rework its massive pension and health-care liabilities as it tries to emerge from bankruptcy.Patriot had made the proposal in mid-November during a private meeting with UMW officials in Charleston, according to court records. UMW lawyers revealed the information Monday in an amended version of their federal court lawsuit against Peabody Energy and Arch Coal, other coal firms that the union alleges helped create Patriot in an effort to get out of their obligation to fund retiree pension and health-care benefits.The details were first reported in The Wall Street Journal, and discussed very briefly by UMW President Cecil Roberts in a press conference prior to a Tuesday protest at Peabody headquarters in St. Louis."Peabody, Arch Coal and Patriot Coal may be proud of the financial con game they're playing on these retirees to get out of decades of promises and obligations," Roberts said. "But the truth is that this is a sickening display of corporate greed that has overstepped the boundaries of decency. In an America where there are few boundaries for corporations, that's saying something.Patriot's bankruptcy has jeopardized the pension and health-care benefits for about 10,000 retirees and another 10,000 dependents. About half of the retirees live in the Illinois coal basin in Illinois, Indiana and Kentucky. Another nearly 40 percent live in West Virginia, according to court records. At Tuesday's protest, more than 750 current and former miners rallied outside the federal building in St. Louis, where a bankruptcy hearing was being held, before marching through the city streets to Peabody's building, according to The Associated Press. Roberts and nine other union members were arrested when they refused to leave after sitting down in the street in front of Peabody's headquarters.Last July, Patriot filed for Chapter 11 bankruptcy, seeking to reorganize amid what the company called "unsustainable labor-related legacy liabilities" including pension and health-care payments and strip-mine reclamation costs.UMW officials say Patriot was essentially a "company created to fail," to give Peabody Energy and Arch Coal a way to shed obligations to fund union pensions and health-care benefits in the nation's eastern coalfields, while profiting from their giant, nonunion surface mines out west.Peabody formed Patriot as a spin-off company where Peabody tucked union mines in West Virginia and the Midwest, along with pension and health-care obligations for union retirees. Patriot later bought another company, Magnum Coal, which had been similarly spun off by Arch Coal when it got rid of most of its Appalachian operations and their related pension and health-care liabilities. The UMW says that 90 percent of the retirees listed as Patriot's obligation today never worked for Patriot, but were instead previously employed by Arch or Peabody.In a class-action lawsuit filed in October in U.S. District Court in Charleston, the UMW and 10 active and retired miners allege that the moves by Peabody and Arch are illegal under a federal law that governs employee benefit plans. Lawyers for Peabody and Arch dispute that and have filed motions to have the case, pending before U.S. District Judge Joseph R. Goodwin, dismissed.Arch Coal had declined comment on the lawsuit, but Peabody spokesman Vic Svec has said Patriot "was a completely viable company" when it was spun off from Peabody in 2007."Substantial events after that time, both inside and outside Patriot, significantly affected its future, from Patriot's transformational acquisition of Magnum Coal Co. to Patriot's decisions to make significant changes in its capital structure," Svec said. "Other factors were decreased demand for U.S. coal due to sharp declines in natural gas prices; the softening of the global steel markets; and more burdensome regulations. Patriot notes many of these same factors in its filings with the bankruptcy court."Along with its union pension and health-care liabilities, Patriot cited environmental costs in its bankruptcy filing, specifically noting that the costs of treating selenium pollution could run into "hundreds of millions of dollars."In November, Patriot agreed to a plan to deal with those liabilities that included its promise to phase out mountaintop removal and other forms of strip mining, a move CEO Ben Hatfield said is in the best interests of the company, its employees and the communities where it operates. Reach Ken Ward Jr. at firstname.lastname@example.com or 304-348-1702. Story Share Story Share Trending Now 1 Police seek car driven by woman found dead in Kanawha River 2 Teen pleads guilty to involuntary manslaughter in Oakes Field shooting 3 Facebook founder visits Cabin Creek Health Systems 4 Man allegedly cuts father in Rand over argument about a sandwich 5 WV school district apologizes for 'Trump Perry' sign at football game Decimated Georgia plant a symbol of storm's power Previous Story As Ala. standoff drags on, town grieves bus driver Next Story


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Flowers Hall
These are female halls primarily for upper-class students, however in some instances first-year students may be permitted to live here. Each is a three-story building and holds 86 residents. The first floor has a Resident Director apartment, lobby space, laundry facilities, community bathrooms and nine 2-person bedrooms. The 2nd and 3rd floors have seventeen 2-person bedrooms, community bathrooms and study lounges.
Amenities include:
- Laundry room
- kitchen
- lobby
- Wi-Fi
- community bathrooms
- air conditioning
- cable and internet in each dorm room


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You've got 600 Facebook friends, 800 Twitter followers and 350 people in your Google (GOOG)+ circles.
How do you keep track of so many people? A growing number of startups is here to help.
Thanks to the geo-location feature built into Apple (AAPL) and Android smartphones, services such as Banjo and Glassmap can tell when someone in your networks — or who simply shares your interests — is nearby.
Another new company, San Francisco-based Ark, offers a "social search engine" to help you find people no matter what social networks they belong to.
"The whole idea is, anywhere you are in the world, you should be able to understand what's going on around you," said Banjo founder Damien Patton. "You and your friends are fragmented across so many different networks."
Patton found that out the hard way in 2009, when he was on a business trip and realized after the fact that he and a former Navy buddy had been passing through the same airport at the same time. He said Banjo, which launched last summer and is based in Redwood City, can troll feeds from any network — Foursquare check-ins, shared photographs on Instagram, Twitter tweets, etc.
"It's one of my top three favorites I can't live without," gushed Shannon Vogel, a social media consultant in Denver. She uses Banjo to see which of her customers are at the same trade shows she attends, and on the weekends, she checks the service to find out which friends are in the neighborhood.
Established social networks like Facebook and tech giants such as Apple and Google also have added location features to help people track down friends in real-time.
Still, critics point out that women in particular may be uncomfortable with apps that readily tell people where to find them.
Privacy concerns helped scuttle the rapid rise earlier this spring of another geo-social startup called Highlight, which hit the top 25 in Apple's App Store after its March debut but sank after a lukewarm reception at the industry trade show SXSW.
Interestingly, when Facebook last month acquired a similar startup, it chose Glancee, which lets you find other people based on distance, common interests and mutual friends — but which doesn't map your precise locale, unlike Highlight and Glassmap.
Glassmap co-founder Geoffrey Woo, who along with two fellow Stanford engineering students dropped out to start the company, understands the concern and said his product lets users control which friends can see their locations. "Some of these apps will have problems going mainstream, because chances are slim someone wants random strangers to approach them at a family dinner," he said.
Though Glassmap was the target of a scathing blog by author Robert Scoble, who felt it doesn't do enough to warn users that their activities may be shared with Facebook friends, Woo said traffic has been growing 30 percent a month since its February launch. (He won't disclose exact numbers, but it's likely far below Banjo's market-leading 1.5 million.)
Glassmap users seem especially to like the fact that, because it doesn't constantly update users' locations, the app doesn't drain cell phone battery life, which was another issue to dog Highlight.
Highlight CEO Paul Davison, for the record, said his company has "dedicated significant engineering resources" to lessen the hit on phone batteries."We've had terrific feedback in the last few months," he added. As for privacy concerns, Davison said Highlight gives users control over how much to share — and, he acknowledged, the company's policies, like geo-social etiquette itself, are "still evolving."
Like Glassmap, Ark is backed by Mountain View incubator Y Combinator and super-angel Ron Conway. Both startups have turned down acquisition feelers from Facebook. But the two take radically different approaches to helping people track their social networks.
Ark was co-founded by Patrick Riley, who'd earned his Ph.D. spurs by developing a search engine to index everything said on broadcast television. His latest project hopes to solve the illogic of "being unable to find a friend's Facebook page when you know it's there, but you can find it on Google."
The startup has indexed more than 1 billion social network profiles, which are searchable by a person's name, school, current city, birthday, employer or favorite band, among a host of categories.
"I like that it's a one-stop shop," said Lauren Prociv, a Virginia Tech student who was one of Ark's first users. "Do you know how hard it is to find someone's email when you have to look in four places?"
She also appreciates that, like Banjo, Ark doesn't display information the user hasn't made public.
Still, Chris Silva, an industry analyst with Altimeter Group, thinks the rapid growth of social-mobile startups is outpacing the number of people who actually want such services.
"My big issue with these apps is, the actual utility is quite low," he said. "Highlight does a great job of alerting me to potentially interesting people, but I've got 750 contacts on LinkedIn." That could lead to a lot of dead-end suggestions to meet people based on tenuous connections, he said.
One geo-social app Silva does speak highly of is Sonar, which lets you know more about the people with whom you're sharing a particular store or restaurant and ranks them based on how many friends you have in common. Other competitors include Glomper, Placeme and Kismet.
But overall, he thinks such startups must deliver better results before earning user trust. "We need to become more sophisticated," he said, "with who gets to scan our social barcode."
Contact Peter Delevett at 408-271-3638. Follow him at Twitter.com/mercwiretap.
Here are some of the "geo-social" startups that use mobile technology to help people find others in their social networks.
Banjo (Redwood City): Culls Twitter tweets, Foursquare check-ins and other social-media messages to let users find nearby friends and people with similar interests.
Glassmap (Mountain View): Always-on connection tracks your cellphone's movements and alerts you when Facebook friends and other people of interest are nearby.
Glomper (Australia): Designed to help you find out what friends and people nearby are up to tonight through check-ins and Facebook posts.
Highlight (Menlo Park): Shows you the name and profile of anybody standing near you who also has the app installed. Also alerts you when friends are nearby.
Kismet (San Francisco): Founded by ex-Googlers, startup lets mobile users meet new people through their existing social graphs.
Placeme (Palo Alto): "Ambient sensing and location platform" remembers where you've gone and suggests things to do.
Sonar (New York): Mobile app that connects you to friends and others nearby, based on your existing social networks, with messaging tools to let you broadcast updates.
Source: Mercury News reporting


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When he wasn't waxing idiotic about airline peanuts, or offending minority groups with his "grandpa rants", writer Andy Rooney (who passed away last year) would occasionally throw us a profound statement or two.
If you're unfamiliar with his work, Andy Rooney is most often remembered (and mocked) for his regular appearance on the CBS program 60 Minutes. In a segment called "A Few Minutes with Andy Rooney" (which ran from 1978 to 2011), the former war correspondent spoke about everything from politics to annoying neighbors. It wasn't always clear WHY he was given airtime to bitch about a defective can opener he once owned, but at times, his long, winding stories would belie deep social commentary and wisdom.
As somewhat of an homage (and because I don't want to write a regular, full-blown blog right now), I decided I would compile four short essays for your consideration. To keep things easily-digestible, I promise that no one subject will contain more than three paragraphs of text. Additionally, each section is designed to just toss out an idea for discussion - it's NOT a comprehensive analysis of the topic at hand.
So, without further ado, let's get started...
The Geeks Won't Inherit the Earth
Unless you've been living under a rock (which is entirely believable, considering the foreclosure rate), you know the economy is bad - and likely won't get better for a while. While I tend to blame the über rich, corporations, and their congressional puppets, as a geek, I can't help but wonder if my own lifestyle and obsessions enable them to steer our economy (and the environment) right off a cliff.
After all, how much longer can we sustain mass-market commercialism that depends on toxic chemicals, overseas slave labor, customer manipulation, and such tremendous energy consumption? Of course, the same can be said of any product or service (and I'm not proposing that we forgo western civilization - even our creature comforts - because China has no respect for human rights). But surely there's a more socially responsible way for us to conduct ourselves...
Still, my greatest concern is that we're ill-prepared for what looks increasingly like a bleak future. If the economy worsens, can you live without a new game every other week? If another pandemic erupts, would you skip the theatrical release of the newest superhero movie? And what if war or limited natural resources make electronics nigh impossible to afford? While I think it's safe to say few of us on MyIGN are rich, it'll be a dramatic shift for us to again view entertainment and technology as "luxuries", not entitlements.
Erections for Douchebags
On that happy note, let's talk about boner pills! There is a certain amount of sexism inherent to the erectile dysfunction industry, wouldn't you say? As we've seen over the last year, certain corporations, religious groups, and even politicians are perfectly fine with insurance providers (including the taxpayer-subsidized Medicare Part D) funding Viagra and Levitra. But where they ABSOLUTELY draw the line...is birth control? So...it's OK to for men to get financial assistance when they need to get their rocks off, but not for women to protect themselves from unwanted pregnancies. Uh-huh.
Now consider this ad for Cialis (another popular ED drug):
Like so many ads before it, we see the female star of this commercial - silly woman that she is - doing something quirky or needlessly complicated (in this case, juggling paperwork and her cellphone, while hopping about to put on her shoes). Of course, her wise (and slightly aroused) husband can only shake his head and laugh: yet another entertaining moment from his ditzy wife.
Why are no women (at the very least) irritated by this? I realize advertising has to be adjusted for different demographics (e.g., the ExtenZe commercials that simplify the female libido to that of a man's - because the target audience is male), but appealing to one group's sexuality doesn't require thinly veiled chauvinism. But then, maybe corporations are taking their misogynistic cues from Congress...
Groovin' with Ganondorf
Recently, azac13 convinced me to purchase Theaterhythm Final Fantasy (for which he heaped glowing praise via Swapnote). Having only played two Final Fantasy games in my LIFE (Crystal Chronicles for the GCN, and Crystal Bearers for the Wii), I'll admit my initial reluctance was due - in no small part - to my relative inexperience and detachment from the series. Still, the game (and the music) is very enjoyable - even if it doesn't "tickle my nostalgia bone" the way Sonic Generations did.
Now, as some of you may know, I have a tendency to be a little OCD...
So I insist that my games be maintained in alphabetical order at all times (even digital downloads). This created a brief moment of indecision for me, as I looked to "file" this game's case with the others. Is it a true Final Fantasy game (which would go between Feel the Magic: XY/XX and Fire Emblem: Shadow Dragon)? Or does it belong with the other "T's" under "Theaterhythm"? (What? Stop laughing! These are critical issues!) Since the box art was no help, I ultimately went with IGN's labeling, placing it snuggly between Tetris Axis and Viva Piñata: Pocket Paradise.
But this got me to thinking: Maybe it isn't just an anniversary celebration of the Final Fantasy series, but a brand-new franchise of rhythm games from SquareEnix! Of course, the next question is, what IP could they now turn to? For me, the logical choice is the Legend of Zelda series (though I suppose Mario, Pokémon, Metroid - hell, ANY classic Nintendo icon would do!). Not only is such a collaboration between the two companies plausible, it would: (A) reaffirm the relationship they had during the SNES days, and (B) be a relatively low-cost/high return investment (esp., if downloadable content is offered). Where's Operation Rainfall when you need them...?
Baby Talk
When I was in school, I was very self-conscious (almost paranoid). I simply didn't like the idea that other people were judging me - including friends and family. It wasn't that I was pining to be popular or stylish (in fact, my mom was more concerned with my wardrobe than I was), but I was scared to say or do anything that would make me appear stupid, "trashy", or ignorant. There's a complex reason those exact words were just chosen, but that's for another blog and another day...
One issue, in particular, haunted me throughout grade school: what I called family members. I come from the South, and most of my family is spread across Texas, Alabama, Florida, and Mississippi. Down here, it isn't uncommon for people - even grown men - to call their parents "Momma" (yes, that IS the correct spelling) and "Daddy". Such is the tradition in our family (though my grandmother and her 10 siblings called their dad "Papa"/"Poppa").
While teachers and other kids found this absolutely hilarious, I was torn between what I and my parents were comfortable with, and what others said was "normal" (usually "Mom" and "Dad"). Of course, the laughs never stop when people find out you call your grandparents "Maw-Maw" and "Baw-Baw" because you couldn't form more traditional words as a baby. But now I'm an adult and, to be honest, I just don't give a fuck. Terms of endearment are entirely subjective, and to judge someone based on long-standing, family nomenclature is a real dick move.
Well...that's probably a lot more profanity than Andy Rooney ever let slip on 60 Minutes, but these are minor topics that didn't each merit their own dedicated blog. Over the course of two weeks, I just wrote short essays about simple issues that I found interesting. Of course, I didn't include EVERYTHING I thought of here, as this is a format I'd like to revisit in the future.
Still, I'd love to discuss these subjects more in the Comments Section below! Do you believe our fandom is contributing to the problems of the world, and are we ready to face the consequences? Did you find the Cialis commercials as sexist as I did? Would you be interested in Theaterhythm: The Legend of Zelda? Have you ever faced ridicule or conflict based on how you address loved ones? Let me know (and thanks for reading)!


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Electronic Ears Emote Fun...
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I experienced many memorable moments during this year's San Diego Comic-Con, but the occasion that stands head and shoulders - or in this case, ears - above the rest was the Necomimi launch party. Necomimi, which appropriately translates as "Cat" and "Ears" in Japanese, is a new brainwave monitoring headset developed by NeuroSky. A leader in "Brain-Computer Interface" (BCI) technologies for consumer product application, some of NeuroSky's most notable product contributions include the ThinkGear chip for use in Mattel's Mindflex and the Star Wars Force Trainer by Uncle Milton. Grounded in proven medical EEG (electroencephalograph) technology, Necomimi is a fascinating electronic device. However, its primary application isn't for the betterment of science or medicine. Necomimi is a prescription for fun.
On July 12th, honored press and media were invited to the Andaz Hotel Rooftop Lounge for the Necomimi U.S. launch party. Already a big buzz in Japan since it's viral video introduction last year, Necomimi is poised to take America by storm... or at least those with an inclination for the strange and wonderful. Looking over San Diego's gorgeous Gaslamp Quarter, guests were encouraged to discover Necomimi firsthand by donning a pair of the moving headsets. With delicious gourmet cupcakes to snack on (with ears, of course) and lovely cocktail waitresses providing friendly service, there was no shortage of neural stimulation for Necomimi to tap.
So how does Necomimi work? First you must correctly place the device on your head. An elastic strap holds Necomimi snug to your head, a comfortable fit, though a tad awkward at first. Next a wire is clipped to you left ear lobe and the headset's forehead sensor must be positioned just so to read your brain waves. It all sounds like the stuff of make-believe science fiction, a thought that entered my mind more than once. Once on, a quick button press on the side activates the device. By utilizing NeuroSky's BCI technology, Necomimi proceeds in reading your mental state and translating it into ear movements to share with those around you. When something grabs your attention, the ears shoot straight up! When you're relaxed, the ears droop down. Since there were no mirrors to admire my emotions by, I had to rely solely on those around me to find out what my ears were doing. However, I could hear them moving, the little servos in Necomimi whirring away. All indications - from the party guests to the sound of my ears in action - showed to me that I was a pretty alert critter that night. Demonstration questions from the Necomimi team, however, took the device in other directions. Asked if I had ever evaded taxes and my ears responded in kind. The Necomimi team knows how to read these devices well, and the signs weren't good for me. I have slightly fudged taxes in the past (who hasn't?)... and it showed. Creepy.
As me and my reporter friend Scott Rubin spent more time wearing Necomimi, we too soon began to understand how to "read" them. We also grew more comfortable with the device, Necomimi acting as an engaging piece of interactive hardware with other people around. And that's the one downside to Necomimi - you really need others with the headset on to fully appreciate it. Wearing these by yourself - while cool for cosplay - just doesn't convey the full fun of Necomimi. Oh, and speaking of cosplay, those looking for a more personalized Necomimi identity will soon have their wish. A company called TeknoFur (Teknofur.com) is already in the process of developing alternative ear designs (some prototypes pictured above). From real animal designs like bear and fox, to even more extravagant concepts like the blue "party" ears. To put them on, simple slide off the pair of white ears that come with the device and pop them on. Necomimi's ears are made to be easily removed for cleaning and replacement.
Are you ready for the Necomimi experience? Necomimi is available now through select authorized resellers priced at $99.95. Visit Necomimi.com to find out more. CLICK HERE for more photos from the San Diego Necomimi Launch Party.


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The Secret in the Dirt Blog
Welcome to the Secret in the Dirt Blog, where members, staff, and guests contribute their wisdom. You can search by category using the menu item above
James Sweeney
Now, I don't know a lot about the technicalities of the golf swing, the subject to which this site is dedicated. But I do want to contribute to the site and to the game. As a student at about a dozen PGA/USGA Rules of Golf workshops, and as a veteran of hundreds of rounds as a rules official, I do know something about the rules. So perhaps I can contribute by clearing up some misinformation or misunderstandings about the rules which spring up from time to time.
Every so often something happens in a televised tournament that creates a mini firestorm over a perception that somehow a player was treated unfairly because of a "stupid" rule. Craig Stadler had the towel incident. Paul Azinger unwittingly kicked away some loose impediments in a hazard. Dustin Johnson grounded his club in a bunker at this year's PGA Championship.
Johnson's situation begat an article in the October 12, 2010 edition of Golf Magazine authored by Contributing Writer, TV Analyst, and Top 100 Teacher Peter Kostis entitled "How To Fix the Five Dumbest Rules in Golf." Unfortunately, this article does a great disservice to the game. From the article's introduction through the five rules Mr. Kostis would have changed, an unwitting reader gets non-truths and misbegotten arguments from someone whom he could reasonably assume is an expert in the subject, a perception legitimized by the fact that the article appears in a respected golf publication.
Over the next few days I will show that every argument made in the Golf Magazine article is based on either misunderstanding or lack of knowledge about the rules. My only object is to set the record straight, at least for whoever reads this blog. My only hope is that the reader gains, perhaps, some greater appreciation of the intent as well as content of the laws that govern how we play the game.


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How long will it take to process my application?
How long will it take to process my application?
After you file your Social Security Disability application the Social Security Administration is allowed 90 to 120 days to make their initial disability decision, and up to 70% of the initial disability applications are denied.
If you are denied at the Social Security Disability application level you have 60 days to file your Reconsideration (which is the first step in the Social Security Disability appeals process) within the Social Security Administration. The SSA may allow another 30 to 90 days to make their decision at the Reconsideration level. Unfortunately, up to 80% of Social Security Disability Insurance and Supplemental Security Income claimants are denied a second time.
What if you are denied a second time? Claimants denied at the Reconsideration level have up to 60 days to request a Social Security Disability hearing. At this point your SSDI or SSI application or claim is sent to the Office of Disability Adjudication and Review (ODAR) for the region that services the area in which you live.
This is where the waiting can really start. In many parts of the country the hearing case loads which are pending number in the hundreds and may be divided among only 5 to 10 Administrative Law Judges. The volume of Social Security Disability cases can be overwhelming for the number of judges available to hear the claims. It is not unusual for disability claimants to wait 12-14 months for a Social Security Disability hearing.
Do all cases go through the same process?
No, the Social Security Administration has aggressively been making changes the disability process and they have created expedited approval process for claimants who application clearly meet the pre-established medical criteria established by the SSA, terminal illnesses (ex. AIDS, ALS, bone marrow transplant cases, any malignant cancer that is metastatic (stage IV), and small cell or oat cell lung cancer), and the wounded warriors program for officers seriously injured or disabled from their military service on or after Oct. 1, 2001,
The bad news is with the down turn in the economy, there have been more workers applying for Social Security Disability benefits than ever before and the number of cases which must be reviewed by the SSA is very high.
What does this mean for you? Unless your mental or physical health condition automatically meets or exceeds a listing on the SSA Listing of Impairments and you are able to avoid all appeals, especially waiting for an administrative hearing, it could take 3 months to 2 years for you to win Social Security Disability benefits.
What if you are approved at some point in the process outlined above? If you are approved at either the application, reconsideration or hearing level, it can take 30 days to 90 days to start receiving benefits. If you are approved for benefits the Social Security Administration will send you a letter which tells you your payment amount and the estimated date of your first payment.


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Karin Mesa
Karin Mesa has worked for the past nineteen years as a designer of decorative glass. She lives on the west coast of Florida with her husband, glass artist, Julian Mesa. Their studio, located in a one acre garden, provides the inspiration of nature that Karin has always used for her illustrations. Throughout her life observing nature has been fuel for Karin's imagination. Jagged tree stumps in a snowy winter became elven castles. Tree frogs nestled among orchid roots whisper of their cozy hidden homes throughout a garden world. Small lives, out of sight to many, are brought to life in water color and pencil. Karin's stories about these small creatures can be applied to their own lives by children, in ways that are real to them as individuals. Karin has stated her purpose in writing and illustrating like this: "I hope that in a light and playful way my stories and pictures will encourage children to develop their creativity and sense of adventure. I want them to know the power they have to change things for the better." Upcoming titles include two more in the Oliver series: Oliver Anole and the Wild Grasshopper Rodeo and Oliver, You Can Read!, Raton Perez meets the Tooth Fairy, The Birdie Tree, and Something the Cat Dragged in.
Upcoming Events
In the Media
Author Website


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Rising CEA after Surgery
Dear OncoLink "Ask the Experts,"
I am a 45-year-old non-smoking male who at 41 was diagnosed with colorectal cancer. My CEA at diagnosis was 57. I had chemo and radiation therapy followed by surgery. Post-op, I had 5-F/U for 3 months. Ten months after surgery, a tumor was detected in my liver and was removed. CEA at the time of liver tumor detection was 8.2. Slowly over the last year my CEA has risen with the most recent number at 21, which jumped from 13. I have repeated CT's and nuclear studies which show nothing. I find it hard to believe nothing can be found. The last colonoscopy was 10 months ago. Any suggestions?
Thank you for your time.
James D. Lewis, MD, MSCE, Assistant Professor of Medicine, Senior Scholar at the Center for Clinical Epidemiology and Biostatistics, and Senior Fellow in the Leonard Davis Institute of Health Economics at the University of Pennsylvania, responds:
This is a difficult clinical scenario. As you know, we use CEA levels to point out that there could be recurrence of the cancer. It is certainly reassuring that your recent CT scans and nuclear studies have not identified a recurrence of your tumor. It would be important to ensure that there is no spread to your lungs, as isolated pulmonary metastases can be resected for cure. This is similar to your liver operation. I would encourage you to go ahead and seek a second opinion with an oncologist who specializes in this area.


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It seems I am in a constant dilemma when it comes to my music career. I simply can't create my albums as fast as I should. Ideally I would like to release an all new full length album every 18 months. However, with all the remixes, live shows and well simple procrastination I never meet my own deadline. It's a shame because I really feel it's important to remain in the eyes and ears of your fans. It's also important if you want a constant strong flow of income from royalties and publishing.
I could put filler music on my albums and get the release out the door. Yet this is a shamefull practice because your seriously devaluing your own art. In the long run you will loose fans and your own self respect. Another thing to consider is if you make every song on your album as perfect as possible then people will listen to it longer. Heck we all own great albums from the 60s we still listen to.
Don't think I can write perfect songs one after another. My absolute biggest trick as a musician is to simply throw away most of the of the music I create. Out of twenty songs I end up finishing I only think eight or ten are worth sharing with the world. Some people say to wait for inspiration to strike but I don't think that works. I find many times I end up with that killer tune only after pulling my hair out on something that started out quite crappy.
The reason this is all on my mind this morning is I am making a major move from Berlin to NYC in a few weeks. I finally will go from being a renter to landlord! There will be about six months of renovation before my all new music studio is a room a can work in. Yes you will see photos of the build and whatever sound treatment we use. Now to my point… I have seven great songs finished for my next album. I really need about twelve. I took what I had to the label that releases my music (www.outofline.de) to discuss the situation. In the end we decided to put off the release until Spring/Summer 2009. This way it will surely be something I am proud of.
Luckily we live in the internet age and because of that there is now distribution from artist to fan. I decided a good compromise would be to give away two of the best songs from the upcoming album to keep myself in the mind's eye. So shortly after I get a little settled in New York and armed with some new promo photos I will do just that. I'll shoot to the world a song I recorded called "Born this Way". Besides my own websites and Social Media spots I will have my friends help me contact the million music blogs out there and see if they want to help spread the tune.
photo credit: in touch


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Star Wars – Just the Essential Plot
Star Wars – Just Chewbacca
Star Wars – Just R2-D2
Star Wars – Just People Saying the Force
Star Wars – Just the Spaceships
Star Wars – Just the Blasters
Star Wars – Just the Jawas
Star Wars – Just Uncle Owen
Everyone has their reasons for loving Star Wars (or not) — some live for Stormtroopers, others are fans of Luke Skywalker and still others just really like Wookiees. Now, thanks to the glories of video editing, it's possible to watch just the things any particular fan wants to see.
The folks at the Cussing Channel — who previously brought you all the gear-shifting in the Fast and the Furious flicks — have now compiled eight supercuts from Star Wars: Episode IV — A New Hope, the seminal sci-fi film that celebrates its 35th anniversary this week.
"We did Star Wars because it was our most requested movie to supercut, by far," Cussing Channel's Jeremy Scott said in an e-mail to Wired. "Because it's so iconic, we thought one supercut wouldn't do it justice … so we blew it up."
He means that literally: One of the supercuts is just a collage of all the scenes where blasters get fired. The others are (in no particular order): A breakdown of just the essential plot, a collection of all the shots of spaceships, reels of nothing but R2-D2 and Uncle Owen, a Jawa compilation and clips of Chewbacca's "dialog" and people saying "the Force."
Check out the supercuts in the clips above, starting with "Just the Essential Plot" (natch).Go Back to Top. Skip To: Start of Article.


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Parade, block party kick off 29th Pride in Fort Worth as organizers get ready to move it downtown next year; annual picnic promises to be bigger than ever, planners say
DAVID TAFFET | Staff Writer email@example.com
Officials with the Tarrant County Gay Pride Parade are planning a big announcement on Sunday during the annual parade along South Jennings Street in Fort Worth: Next year's 30th annual Tarrant County Gay Pride Parade will move to Downtown Fort Worth, according to parade chair Tony Coronado.
But first, Tarrant County's LGBT community gets to party at this year's parade and picnic. And they don't have to wait for 2011 to start getting a taste of something new in Tarrant County Pride.
This year's parade follows the same route as previous years, but reverses direction, marching toward downtown in anticipation of next year's move, Coronado said. The 29th annual Pride parade begins at 2 p.m. on Sunday, Oct. 3.
An addition to this year's parade is a block party. The intersection of South Jennings and Pennsylvania avenues near the end of the parade route will be closed for the day for the event.
The Rev. Carol West of Celebration Community Church and Mr. Gay Pride Week Scott Wasson Conger are the parade grand marshals. Fort Worth PD's LGBT Liaison Officer Sara Straten and Chief of Police Jeffrey Halstead are honorary grand marshals.
Among the 50 entries in this year's parade are several, including Resource Center Dallas and American Airlines, that marched two weeks ago in the Alan Ross Texas Freedom Parade in Dallas.
Members of Club Los Rieles saw Tarrant County Gay Pride Week Association's entry in the Dallas parade and approached Coronado about participating. They'll be traversing the parade route on horseback in the Tarrant County Pride parade this weekend.
Tarrant County Gay Pride Week Association President Jody Wasson said Pride Pets is the big addition to this year's parade. Pets will be judged in three categories according to size. Prizes will be given for best-dressed pet and best-dressed pet and owner.
At 4 p.m. during the block party, pets will be judged on behavior, obedience, grooming and manner. A king and queen will be awarded rhinestone crowns and royal capes.
They will preside over next year's pet entries and will ride their own float in the 2011 Pride Parade.
Jazz-rockabilly-blues group Aurora Bleu performs on the block party main stage at 3 p.m.
Coronado said that although it is too late to enter the parade, those who are interested can still apply vendor booths at the block party.
"We'll fit 'em in," Coronado said. "If you would like to do business and market to us, this is a great place to start."
He said that because Fort Worth's LGBT community is so spread out, this is the best place to reach this market.
Additional events are planned throughout Pride Week, culminating in the Pride Picnic on Oct. 10.
QCinema screens "Beyond Gay: The Politics of Pride" at Four Day Weekend Theater in downtown Fort Worth at 8 p.m. on Monday Oct. 4.
Best Friends Club has game night on Tuesday, Oct. 5 at 7 p.m. and Pride Karaoke on Wednesday, Oct. 6 at 9:30 p.m.
Fort Worth's Imperial Court holds its Texas Sweetheart Ball in memory of Taylor Vaughan at the club on Thursday, Oct. 7. And the Texas Gay Rodeo Association performs at the bar on Friday, Oct. 8.
Rhonda Mae presents her annual "Wall of Food Show" at Changes on Wednesday, Oct. 6 at 9 p.m.
Tarrant County Pride Week ends with the annual Pride Picnic in Trinity Park near the 7th Street Pavilion.
Dianne Dunivan is the chair of the picnic. She said this event has "expanded the area a bit" this year, and there will be two stages instead of one.
Entertainment runs on the Bud Light Main Stage from 1 p.m. to 6 p.m. Local singer Kylie D. Hart and country performer James Allen Clark will be featured on the main stage. A number of groups, including a local stomp troop, will also perform through the afternoon.
On the second stage, a DJ will spin music.
Vendors will be in a tent.
"We're attracting some vendors from out of state," said co-chair Tina Harvey. "We've got a couple of spots left. That's it."
But, she said, with enough last-minute vendors, they would rent a second tent.
Harvey said about 40 vendors scheduled include community groups, T-shirt vendors, jewelry and crafts sellers, churches and an attorney.
"The attorney has lots of information on adoption by same-sex couples and estate planning," Harvey said.
She said the picnic setting is better for taking some time to sit down and talk about adoption or getting involved in community groups than the block party.
Harvey said that hamburgers, hot dogs and beer will each be $1 this year. At past picnics, food was free but mounting the downtown parade will cost more than this year.
"So we're getting people used to paying a little," Harvey said.
Dunivan added that the charge should cut down on waste as well. She said that people are also welcome to bring their own coolers and grills.
Picnic activities will include volleyball, horseshoes, tug-of-war and sack races. She said high-heel drag races and wheelbarrow races have been popular events at past Pride picnics.
About 200 children participated in the kids' area last year. Face painters and balloon artists are this year's addition to that section.
Harvey said that next year they're planning events throughout the week and are hoping that people who come to town for Pride will stay for the full week.
Dunivan said the picnic is like homecoming.
"Come out and enjoy the day," she said.
This article appeared in the Dallas Voice print edition October 01, 2010.


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'Campbell missed three games after he was possibly exposed to severe acute respiratory syndrome (SARS) following a visit last week from his sister, who was later hospitalized after showing symptoms. He and his roommate, defenseman Rhett Warrener, were separated from the team as a precaution.'
You are here: Home / SabresBeat / Buffalo D Campbell returns to practice; cleared to play


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Media Contact: TPWD News, email@example.com, 512-389-8030
Oct. 29, 2013
Second Defendant in State Game Warden Hostage Case Pleads Guilty
AUSTIN – The son of a former Upshur County commissioner arrested in October 2012 for holding a state game warden at gunpoint has pled guilty to one count of unlawful restraint, a Class A misdemeanor.
In 115th Dist. Court, Judge Lauren Parish sentenced 28-year-old Todd A. Crabtree to a one-year jail sentence, probated for two years. In addition, Crabtree was ordered to publicly apologize to the game warden and other law enforcement officers who responded to the scene last year.
Crabtree also will have to pay a $250 fine, take an anger management class, pay court costs and other fees as well as perform 100 hours of community service. While on probation he will have to submit to monthly drug tests and will be barred from drinking alcohol. He also will be prohibited from possessing any firearms or ammunition during his probation.
The charges to which Crabtree pled guilty stem from an Oct. 6, 2012 incident in which the game warden was disarmed and detained by two armed men while the officer was making a routine check for hunting law violations on private property in Upshur County.
The game warden used his cell phone to call for help, and soon numerous local and state officers came to his assistance and ended the situation with no shots fired.
"The Texas Parks and Wildlife Law Enforcement Division fully supports this plea agreement as well as the previous plea agreement regarding Lloyd Crabtree," said TPWD Law Enforcement Division Director Col. Craig Hunter.
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No, he wasn't using it out of context...when I laughed and explain, he gave a silly grin and said, "Oh".
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No, he wasn't using it out of context...when I laughed and explain, he gave a silly grin and said, "Oh".
Probably ought to address the "their", "there", and "they're" situation as well....
I have no ideal what you guys are all talking about... All your points are probably mute anyways..
The one that is always cringe worthy for me and don't think it is so much a problem on this board is loose instead of lose. You see this all the time in various video game communities or where the average person is of younger age. Come on younger generation is it really that hard to know that loose is the opposite of tight and LOSE is the opposite of win.
I am glad us intellectuals have finally made a thread about using gooder grammar.
"We've got to be very clear about this. We don't want our players hanging around with murderers," said Larry Bird, Pacers president.
jus don't get us strted bout txtng runon sentces w/o puntaton always captoliz firs words minmze types din"t forge typ all of words rereader wut u post b4 2 make sur makes sents too ppl u don't no they migt not no wut ur tlkng about they prbly get mad strt tell u how 2 post wut rit they hav 2 due that am I rit or am I rit LOLOLOLOLOL
Just don't get us started about texting run-on sentences without punctuation. Always capitalize the first words of each sentence. Minimize typos and don't forget to type all of the words you intend to include in your post to properly express a complete thought. As a suggestion, please re-read what you are about to post to make sure that it makes sense both to you as well as to others who don't know you. If others don't know you, or are unfamiliar with your viewpoints and posting style, they may not be able to figure out what you are talking about. Some people probably will get irritated and either no longer bother to read your posts, or worse, they may start telling you how you need to post.
You are likely thinking "What right do they have to do that?!?! Am I right, or am I right?", after which you will have a hearty laugh to yourself, after which you will continue about your posting, hopefully in a coherent fashion.
[~]) ... Cheers! Go Pacers!
Then and than.
It never bothers me when anyone corrects my grammar. We all need a little correcting sometimes. Although my bigger problem is typos.
I agree, I always screw up typing they're and their. I know the difference, I usually catch it immediately after, but my fingers can't get it through their little minds that their is not the equivalent to they're.
The one I see on here a lot is "defiantly" when they meant "definitely".
Your and you're drives me nuts.
to instead of too (not to be one of those guys, but this happens a lot in "Odd Thoughts")
Hanging prepositions drive me up the wall. Just because you stick another word after it doesn't make acceptable. Most people think that you just can't end a sentence in a preposition, but there are so many sayings that misuse them so it can be difficult.
The one I always struggle with is "its" and "it's". My grammar has started to go done hill since I left school.
PG24: "Don't tell me the sky is the limit when there are footprints on the moon!"
RT @Hoya2aPacer "When I play this game I love. I play to make my teammates better. But I'm a mouther****er on defense."
I got your back.
This space for rent.
LOL. It was late.
PG24: "Don't tell me the sky is the limit when there are footprints on the moon!"
RT @Hoya2aPacer "When I play this game I love. I play to make my teammates better. But I'm a mouther****er on defense."
The bummer for me is when I use an IPad or an IPhone and auto-complete and the spelling corrector kicks in. Its will always end up as it's unless you backspace and correct it. There are a ton of other examples as well. And if I attempt to use the touch screen too quickly, I end up with a bunch of missed letters, so a simple word like "the" will end up as "he".
It's enough to drive a detailed perfectionist nuts. Or from some of your perspectives, it's enough to assure that I remain nuts. Whichever.
I work with a guy who says "granite" when he means "granted". He will say "Now don't take it for granite...."
Drives me in-FREAKING-sane!
Well, I'd say about 50% of my grandfather's statements don't have no double negatives in them. One time he was about to use one of those rare triple negatives, but he caught himself on the third one and corrected it and I was like " Noooo, why God, WHY!".
Also, I never really Know where my periods (.) belong when use quotations or parenthesis (wait, is there two spellings of that).
Last edited by Richard_Skull; 11-14-2013 at 02:54 PM. Reason: A GLARING Grammar Error in the GRAMMAR THREAD
PG24: "Don't tell me the sky is the limit when there are footprints on the moon!"
RT @Hoya2aPacer "When I play this game I love. I play to make my teammates better. But I'm a mouther****er on defense."
My personal pet peeves are when someone says, "I could care less" instead of "I couldn't care less". Another is when someone mistakes the word "to" with "too" (meaning also). The third peeve is when someone mistakes the word "specific" with "pacific". This last example happens more often in speech than on this forum but the two words are polar opposites in their meaning.
Ultimately, grammar isn't that big of a deal in this forum because it doesn't impact the Pacers win/loss record. We need to keep it in it's proper perspective.
Technical grammar says punctuation goes inside the quotes. Modern in-use style has begun accepting punctuation outside the quotes when the punctuation is not part of the quoted phrase. I don't think any of the manuals of style have picked that up yet.
A bird in the hand is worth two in the bush.
Or throw in a first-round pick and flip it for a max-level point guard...
Saw this quote and thought of this thread:
Justin Timberlake, feel free to subscribe to the thread."So I find it ironic that I'm doing an interview with you about Man of the Year when I feel — literally — like a bunch of people just took a s--t on my face," the 32-year-old musician/actor says in the first line of the article.
A bird in the hand is worth two in the bush.
Or throw in a first-round pick and flip it for a max-level point guard...
But, honestly, I'm not sure if punctuation should be including in a topic concerning grammar. It's more an issue of style, as you are alluding to, than one that can hinder understanding (such as misuse of words).
EDIT: Unless it's something like "man, eating dog" or "man-eating dog."
Last edited by kidthecat; 11-12-2013 at 05:26 PM.


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Youth Orchestra of Bucks County Open Rehearsal
Saturday, May 04, 2013
Where and When
Time: 1:30 pm - 4:00 pm
Location: Gateway Auditorium
Contact: firstname.lastname@example.com
Event Information
GRAMMY award-winning violinist and composer, Mark O'Connor rehearses his composition The Improvised Violin Concerto with the YOBC Symphony Orchestra. Free and open to the public. Tickets to the concert, at Patriots Theater at the Trenton War Memorial on Sunday May 5th, may be purchased on the Patriots Theater website.