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Celgene International Sárl
) Reports POMALYST Met Prrimary Endpoint in Phase 3 Trial
Results from Phase III Study (MM-003) of Pomalidomide Plus Low-Dose Dexamethasone versus High-Dose Dexamethasone in Relapsed and Refractory Multiple Myeloma Patients Published in The Lancet Oncology
BOUDRY, Switzerland--(BUSINESS WIRE)-- Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation (CELG), today announced that updated results from MM-003, a phase III multi-center, randomized open-label study (n=455) of pomalidomide (marketed as POMALYST® in the U.S. and IMNOVID® in the E.U.) plus low-dose dexamethasone, were published online ahead of print in The Lancet Oncology.
The study compared oral pomalidomide plus low-dose dexamethasone with high-dose dexamethasone in patients with refractory or relapsed and refractory multiple myeloma who have failed at least two prior therapies with both bortezomib and lenalidomide, administered alone or in combination.
At the interim analysis (ASH 2012, median follow-up 4.2 months), the study met its primary endpoint as pomalidomide plus low-dose dexamethasone demonstrated a significant improvement in progression-free survival (PFS) (3.8 months vs 1.9 months HR 0.41 p
Additionally, the Data Monitoring Committee recommended that patients who had not yet progressed in the high-dose dexamethasone arm should have access to pomalidomide with or without low-dose dexamethasone.
At a median follow-up of 10.0 months, an updated PFS analysis and final OS analysis were conducted. Pomalidomide plus low-dose dexamethasone continued to demonstrate significantly longer PFS, the primary endpoint, compared with high-dose dexamethasone (4.0 months vs. 1.9 months, HR=0.48, p
The most common grade 3-4 hematological adverse events in the pomalidomide plus low-dose dexamethasone and high-dose dexamethasone arms, respectively, were: neutropenia (48% 143/300 vs. 16% 24/150), anemia (33% 99/300 vs. 37% 55/150) and thrombocytopenia (22% 67/300 vs. 26% 39/150). Grade 3-4 non-hematological adverse events in the pomalidomide plus low-dose dexamethasone and high-dose dexamethasone arms, respectively, included: pneumonia (13% 38/300 vs. 8% 12/150), bone pain (7% 21/300 vs. 5% 7/150) and fatigue (5% 16/300 vs. 6% 9/150). Four patients in the pomalidomide plus low-dose dexamethasone arm and one patient in the high-dose dexamethasone arm developed second primary malignancies. Of these, two patients in the pomalidomide plus low-dose dexamethasone arm had invasive solid tumor cancers and two patients in this group and the one in the high-dose dexamethasone group had non-invasive cancers (basal-cell skin cancers). Treatment-related adverse events led to treatment discontinuation in 4% of patients in the pomalidomide plus low-dose dexamethasone arm and 6% of patients in the high-dose dexamethasone arm.
Patients in the pomalidomide plus low-dose dexamethasone arm received 4 mg of oral pomalidomide on days 1-21 of each 28-day cycle. Oral dexamethasone was given at 40 mg on days 1, 8, 15, and 22); for patients older than 75 years, dexamethasone was administered at 20 mg weekly.
Patients in the comparator arm were treated with 40 mg oral high-dose dexamethasone on days 1-4, 9-12 and 17-20 of each 28-day cycle, until disease progression; patients older than 75 years received 20 mg oral dexamethasone on the same schedule.
Results of the MM-003 trial formed the basis of an August 2013 approval by the European Medicines Agency in patients with relapsed and refractory multiple myeloma who have received at least two prior therapies including both lenalidomide and bortezomib and have demonstrated disease progression on the last therapy.
For more information, visit http://www.thelancet.com/journals/lanonc/onlinefirst
Important Safety Information based on approved U.S. Label for Pomalyst (Trade name for Pomalidomide Celgene in the U.S.)
WARNING: EMBRYO-FETAL TOXICITY and VENOUS THROMBOEMBOLISM
Embryo-Fetal Toxicity
POMALYST is contraindicated in pregnancy. POMALYST is a thalidomide analogue. Thalidomide is a known human teratogen that causes severe birth defects or embryo-fetal death. In females of reproductive potential, obtain 2 negative pregnancy tests before starting POMALYST treatment
Females of reproductive potential must use 2 forms of contraception or continuously abstain from heterosexual sex during and for 4 weeks after stopping POMALYST treatment
POMALYST is only available through a restricted distribution program called POMALYST REMSTM.
Venous Thromboembolism
Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) occur in patients with multiple myeloma treated with POMALYST. Prophylactic anti-thrombotic measures were employed in the clinical trial. Consider prophylactic measures after assessing an individual patient's underlying risk factors
CONTRAINDICATIONS: Pregnancy
POMALYST can cause fetal harm and is contraindicated in females who are pregnant. If this drug is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus
Pomalidomide is a thalidomide analogue and is teratogenic in both rats and rabbits when administered during the period of organogenesis.
Embryo-Fetal Toxicity
Females of Reproductive Potential: Must avoid pregnancy while taking POMALYST and for at least 4 weeks after completing therapy. Must commit either to abstain continuously from heterosexual sexual intercourse or to use 2 methods of reliable birth control, beginning 4 weeks prior to initiating treatment with POMALYST, during therapy, during dose interruptions and continuing for 4 weeks following discontinuation of POMALYST therapy. Must obtain 2 negative pregnancy tests prior to initiating therapy.
Males: Pomalidomide is present in the semen of patients receiving the drug. Males must always use a latex or synthetic condom during any sexual contact with females of reproductive potential while taking POMALYST and for up to 28 days after discontinuing POMALYST, even if they have undergone a successful vasectomy. Males must not donate sperm
Blood Donation: Patients must not donate blood during treatment with POMALYST and for 1 month following discontinuation of the drug because the blood might be given to a pregnant female patient whose fetus must not be exposed to POMALYST
POMALYST REMS Program
Because of the embryo-fetal risk, POMALYST is available only through a restricted distribution program under a Risk Evaluation and Mitigation Strategy (REMS) called "POMALYST REMS." Prescribers and pharmacists must be certified with the program; patients must sign an agreement form and comply with the requirements. Further information about the POMALYST REMS program is available at [celgeneriskmanagement.com] or by telephone at 1-888-423-5436.
Venous Thromboembolism: Patients receiving POMALYST have developed venous thromboembolic events reported as serious adverse reactions. In the trial, all patients were required to receive prophylaxis or antithrombotic treatment. The rate of DVT or PE was 3%. Consider anticoagulation prophylaxis after an assessment of each patient's underlying risk factors.
Hematologic Toxicity: Neutropenia of any grade was reported in 50% of patients and was the most frequently reported Grade 3/4 adverse event, followed by anemia and thrombocytopenia. Monitor patients for hematologic toxicities, especially neutropenia, with complete blood counts weekly for the first 8 weeks and monthly thereafter. Treatment is continued or modified for Grade 3 or 4 hematologic toxicities based upon clinical and laboratory findings. Dosing interruptions and/or modifications are recommended to manage neutropenia and thrombocytopenia.
Hypersensitivity Reactions: Patients with a prior history of serious hypersensitivity associated with thalidomide or lenalidomide were excluded from studies and may be at higher risk of hypersensitivity.
Dizziness and Confusional State: 18% of patients experienced dizziness and 12% of patients experienced a confusional state; 1% of patients experienced grade 3/4 dizziness, and 3% of patients experienced grade 3/4 confusional state. Instruct patients to avoid situations where dizziness or confusion may be a problem and not to take other medications that may cause dizziness or confusion without adequate medical advice.
Neuropathy: 18% of patients experienced neuropathy (approximately 9% peripheral neuropathy). There were no cases of grade 3 or higher neuropathy adverse reactions reported.
Risk of Second Primary Malignancies: Cases of acute myelogenous leukemia have been reported in patients receiving POMALYST as an investigational therapy outside of multiple myeloma.
In the clinical trial MM-002 of 219 patients who received POMALYST alone (n=107) or POMALYST + low-dose dexamethasone (low-dose dex) (n=112), all patients had at least one treatment-emergent adverse reaction.
In the POMALYST alone versus POMALYST + low dose dexamethasone arms, respectively, most common adverse reactions (=30%) included fatigue and asthenia (55%, 63%), neutropenia (52%, 47%), anemia (38%, 39%), constipation (36%, 35%), nausea (36%,22%), diarrhea (34%, 33%), dyspnea (34%, 45%), upper respiratory tract infection (32%, 25%), back pain (32%, 30%), and pyrexia (19%, 30%)
90% of patients treated with POMALYST alone and 88% of patients treated with POMALYST + low-dose dex had at least one treatment-emergent NCI CTC Grade 3 or 4 adverse reaction
In the POMALYST alone versus POMALYST + low dose dexamethasone arms, respectively, most common Grade 3/4 adverse reactions (=15%) included neutropenia (47%, 38%), anemia (22%, 21%), thrombocytopenia (22%, 19%), and pneumonia (16%, 23%). For other Grade 3 or 4 toxicities besides neutropenia and thrombocytopenia, hold treatment and restart treatment at 1 mg less than the previous dose when toxicity has resolved to less than or equal to Grade 2 at the physician's discretion
67% of patients treated with POMALYST and 62% of patients treated with POMALYST + low-dose dex had at least one treatment-emergent serious adverse reaction
In the POMALYST alone versus POMALYST + low dose dexamethasone arms, respectively, most common serious adverse reactions (=5%) were pneumonia (14%, 19%), renal failure (8%, 6%), dyspnea (5%, 6%), sepsis (6%, 3%), pyrexia (3%, 5%) dehydration (5%, 3%), hypercalcemia (5%, 2%),urinary tract infection (0%, 5%), and febrile neutropenia (5%, 1%)
No formal drug interaction studies have been conducted with POMALYST. Pomalidomide is primarily metabolized by CYP1A2 and CYP3A. Pomalidomide is also a substrate for P-glycoprotein (P-gp). Coadministration of POMALYST with drugs that are strong inhibitors or inducers of CYP1A2, CYP3A, or P-gp should be avoided. Cigarette smoking may reduce pomalidomide exposure due to CYP1A2 induction. Patients should be advised that smoking may reduce the efficacy of pomalidomide.
Pregnancy: If pregnancy does occur during treatment, immediately discontinue the drug and refer patient to an obstetrician/gynecologist experienced in reproductive toxicity for further evaluation and counseling. Report any suspected fetal exposure to POMALYST to the FDA via the MedWatch program at 1-800-332-1088 and also to Celgene Corporation at 1-888-423-5436.
Nursing Mothers: It is not known if pomalidomide is excreted in human milk. Pomalidomide was excreted in the milk of lactating rats. Because many drugs are excreted in human milk and because of the potential for adverse reactions in nursing infants from POMALYST, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Pediatric Use: Safety and effectiveness of POMALYST in patients under the age of 18 have not been established.
Geriatric Use: No dosage adjustment is required for POMALYST based on age. Patients greater than or equal to 65 years of age were more likely than patients less than or equal to 65 years of age to experience pneumonia.
Renal and Hepatic Impairment: Pomalidomide is metabolized in the liver. Pomalidomide and its metabolites are primarily excreted by the kidneys. The influence of renal and hepatic impairment on the safety, efficacy, and pharmacokinetics of pomalidomide has not been evaluated. Avoid POMALYST in patients with a serum creatinine >3.0 mg/dL. Avoid POMALYST in patients with serum bilirubin >2.0 mg/dL and AST/ALT >3.0 x ULN.
Please see full U.S. Prescribing Information, including Boxed WARNINGS, CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS, and ADVERSE REACTIONS.
About pomalidomide
Pomalidomide is an oral immunomodulatory drug (IMiD®) with a multimodal mechanism of action consisting of three main effects demonstrated in vitro: direct antimyeloma, stromal inhibitory effects and immunomodulatory effects. Pomalidomide in combination with dexamethasone has been approved in the EU for the treatment of adult patients with relapsed and refractory multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on the last therapy.
In addition to the EC decision for the EU, pomalidomide is approved in the United States under the brand name POMALYST® and is under review in other countries.
In the United States, Pomalyst is approved for use in patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion on the last therapy. Approval is based on response rate. Clinical benefit, such as improvement in survival or symptoms, has not been verified.
About Celgene
Celgene International Sàrl, located in Boudry, Switzerland, is a wholly-owned subsidiary and international headquarters of Celgene Corporation. Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global pharmaceutical company engaged primarily in the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. For more information, please visit www.celgene.com.
Forward-Looking Statements
This press release contains forward-looking statements, which are generally statements that are not historical facts. Forward-looking statements can be identified by the words "expects," "anticipates," "believes," "intends," "estimates," "plans," "will," "outlook" and similar expressions. Forward-looking statements are based on management's current plans, estimates, assumptions and projections, and speak only as of the date they are made. We undertake no obligation to update any forward-looking statement in light of new information or future events, except as otherwise required by law. Forward-looking statements involve inherent risks and uncertainties, most of which are difficult to predict and are generally beyond our control. Actual results or outcomes may differ materially from those implied by the forward-looking statements as a result of the impact of a number of factors, many of which are discussed in more detail in our Annual Report on Form 10-K and our other reports filed with the Securities and Exchange Commission.
Celgene International Sàrl
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+41 32 729 8304
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The latest episode of Disc Golf Live video magazine has been sent to our broadcast partners across the country and posted for downloading at PEGmedia.org. DGL is created for broadcast on community access TV stations (there are hundreds of them where the show is not yet playing) to grow our favorite sport. Copies of our broadcast DVDs and downloads are free. If you need a hand working out your local station guidelines and procedures, drop us a line and we'll help you through the process. If you're looking for a way to promote the sport locally, you can't go wrong with TV broadcasts. Check your local cable listings and watch for contact info.
For those without local access TV, our full episodes are up on Youtube as well.
Part one of this episode begins with action from Disc Girls Gone Wild, a ladies-only event featuring dominant play by Liz Lopez. Next comes a tour of Charlotte's Web in advance of next summer's PDGA Worlds in NC. Big Jerm plays the course, while Stan McDaniel and Billy Crump talk course design theory.
Part two of this episode starts with early round action from the 2011 US Am Nationals on the Toboggan course, and then the action moves to Finland for the Scandinavian video mafia's take on the Mukkula Open. The show wraps up with footage of the Disc Girls throwing off for the ace pool cash as the credits roll.
Part 1: http://youtu.be/R0zJAHNABww
Part 2: http://youtu.be/qfLy0ha-nQo
We're always looking for broadcast opportunities, so be on the look out for a local access station in your area. We also welcome your submissions for the show, so if you have a story to tell, get in touch with us and we'll see how we can add your voice and story to the mix. Thanks to the PDGA, Innova, and Discraft for their ongoing support of DGL.
Best regards,

subset: commoncrawl


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Biomod/2012/Tohoku/Team Sendai
From OpenWetWare
Tohoku University
All the creatures on Earth are made of cells. The exterior and the interior of the cell are compartmentalized by biomembranes.
A nanodevice that is able to actively transport only the specific oligonucleotide through the biomembrane has a great potential to deliver siRNA into the cell or to extract mRNA expressed in the cell.
Here, we decided to create a novel device with such a function.
We have designed a cylindrical injector/extractor device made of DNA origami. Inside the cylinder, a cascade of single stranded DNAs is planted. Once the outer-most ssDNA binds to a target oligonucleotide, the target is passed to the inner-ones one by one because of the higher bonding energy assigned to the inner ones.
We also investigate how the cylinder penetrates the biomembrane by using liposome as a model membrane.
Project Image
Porter: Single stranded DNA. Once the outer-most ssDNA binds to a target, the target is passed to the inner-ones one by one. Gate: Cylindrical structure connecting the inside and outside like gates. A cascade of the "Selector" is planted in this. We can use this as an injector or extractor. Membrane: The exterior and the interior of the cell are compartmentalized by biomembranes. We use liposome as a model membrane.
|Coming soon...


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Besides the need to raise private funds, newly appointed Cal State Northridge President Dianne Harrison has one pressing concern.
Whether the Proposition 30 tax measure passes or not, her Northridge campus will lose millions. Either way, that means thousands of fewer classes and at least one more semester until students graduate. | Main story: As CSU campus budgets drop, university presidents get big raises
"If Prop. 30 fails, we lose big," said Harrison, who replaced former President Jolene Koester this summer. "If it passes, we lose less.
"We have to get the citizens and elected officials to reinvest, and to let us control our own destiny."
Victory for the November tax measure endorsed by Gov. Jerry Brown would force CSUN to give back this year's 9 percent tuition increase -- $10.2 million -- and forgo the extra revenue for years to come.
Failure would trigger a $250 million cut to the California State University system, whose current budget assumes voter approval.
That, in turn, would require millions of dollars in cuts at each of 23 CSU campuses, including Northridge. After factoring in revenue from the 5 percent tuition hike proposed for spring, CSUN stands to lose $16.2 million.
That equates to a spring semester loss of 325 instructors, 2,400 class sections and two hours per day whittled from the campus library and computer lab, Harrison said.
Since fewer classes mean less campus capacity, that means each CSUN student may take an extra semester to get into required classes -- and cost each $4,000 more to graduate, Harrison said.
On average, CSUN freshmen now take five years to graduate, while transfer students take three years to get their diplomas.
The campus squeeze also means CSUN is poised to turn away up to half its incoming freshman and transfer students, which would further jam the area's community colleges. Fewer pupils, in turn, mean the university would shrink its population of 36,700 students.
"After all that," Harrison said, "if we have fewer students, the state is going to fund us less. Cut us open. Pour some acid on it. It's horrible.
"We're facing a downward spiral."
Harrison, who took the reins at CSUN last June, earns $324,500, nearly $30,000 more than her predecessor. She was recruited from Cal State Monterey Bay, where she earned $270,315.
Like other campus presidents, one of her prime roles is fundraising.
Last year, CSUN took in $11.4 million in private gifts, or 70 percent of its $13 million goal, administrators say
This fiscal year -- which corresponds with Harrison's tenure -- it's had a surge in donations. Since July 1, it's raised $6.2 million, roughly half given by an anonymous couple toward middle-class student scholarships. Another verbal pledge was made for $1.5 million.
Where fundraisers still struggle is drawing donations from the realm of struggling average Janes and Joes, or between $50 and $250.
"As we turn the corner from a state-supported university to a state-assisted institution, we will need (donations) more than ever," said Vance Peterson, vice president for advancement and president of the CSUN Foundation.
"Just the act of writing a check tells your alma mater that you care."
University officials said they've done everything to cut the fat from what they claim is the most efficient university system in the nation
They've frozen salaries and any nonessential hiring. They now raise 70 percent of funds through tuition, fees and private sources.
Analysts said the Proposition 30 tax measure is critical to restoring quality public universities and colleges.
"The election will be a really, really big moment for California," Raphael Sonenshein, executive director of the Pat Brown Institute for Public Affairs at CSU Los Angeles.
"The funding stream for K-12 and higher ed has been so severely impacted. The props would provide the resources to hold the line while the state's leaders come up with a more sustainable plan.
"Without that, the system is in danger of going down the tube. I don't remember another ballot measure that would have such a significant impact on the state's public universities."
Nonetheless, a passage of Proposition 30 will still likely mean a huge dent in services.
Rebating the 9 percent tuition increase would cost CSUN more than $10 million and means losing the same amount in tuition next year.
That could mean the loss of 2,000 class sections, Harrison said, with potential cuts to continuing education.
"In spite of those draconian consequences," she said, "our faculty and staff are still focusing on providing students with a high-quality education ... (though) no doubt, it'll probably take longer."


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vitamin b5 (generic name)
It is part of the B complex group of vitamins
(PAN to THEN ik AS id)
Table of Contents
Top Learning Centers(Recursos en Español)
What is this medicine?PANTOTHENIC ACID (PAN to THEN ik AS id) is a naturally occurring vitamin found in beans, peas, meat, poultry, fish, and whole-grain cereal. It is part of the B complex group of vitamins. This vitamin aids in the release of energy in cells and helps support a healthy nervous system.
What should I tell my health care provider before I take this medicine?They need to know if you have any of the following conditions:
How should I use this medicine?Take this medicine by mouth with a glass of water. Follow the directions on the label. Take your medicine at regular intervals. Do not take your medicine more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. While this medicine may be used in children for selected conditions, precautions do apply.
What if I miss a dose?If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?Interactions are not expected.
What should I watch for while using this medicine?Make sure you have a proper diet. Taking this vitamin does not replace the need for a balanced diet.
What side effects may I notice from receiving this medicine?Side effects that you should report to your doctor or health care professional as soon as possible:
Where should I keep my medicine?Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


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Dickerdoodle Winners!
This year's Dickerdoodle contest was awesome. You guys are a sick bunch of fuckers. Choosing a top three was no easy task but I've finally done it.
First Place goes to Breanne!
I have looked at this image probably a hundred times and I still laugh. Something about the expression on the cat's face just kills me. It's like he's not trying to show off or boast. This is his massive dong and you just need to deal with it. If you can't come to terms with his giant shlong that's your problem not his.
Second Place goes to Robert!
There is just something magical about this photo. There's an authenticity of emotion present that is both terrifying and beautiful.
Third place goes to Zach!
This little play deserves a slow standing ovation followed by the wiping away of a single tear. Brilliant.
I will be sending out a prize package to each of these winners in the next few days.
I received nearly three hundred entries this year. I've narrowed that down to around thirty of my favorites, and I'll be putting up a gallery shortly. Thanks to everyone who entered this year, you guys never cease to amaze me with your depravity.
-Gabe out


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After a big drop this summer, garlic prices stabilized in September, and some shippers said they could begin to tick up again.
Maurice A. Auerbach Inc., South Hackensack, N.J., wrapped up its Mexican garlic deal around the end of August and was shipping from California and China in mid-September, said Paul Auerbach, the company's president.
Because of a big Chinese crop, fresh prices were about half what they were six months ago, Auerbach said Sept. 19. But prices were starting to inch up as China switched to shipments from cold storage, he said.
That reversal has come as a surprise to "most everyone" in the garlic industry, said Jim Provost, president of West Grove, Pa.-based I Love Produce, who visits China three times a year.
"When the crop was harvested in June, it seemed there would be overproduction, especially as compared to the last two years," Provost said. "Buyers were prepared to manage a low-price year."
And prices were cheap in June and July, Provost said. But extremely strong demand, coming on the heels of high prices from the previous season's short crop, soon stopped the downward trend of prices.
By early October at the latest, U.S. markets will start to feel the upward pressure on pricing because of strong pull worldwide, Provost said.
On Sept. 20, 30-pound cartons of white netted garlic 3s from China sold for $32-34 on the Los Angeles terminal market, comparable to last year at the same time.
Ten-pound cartons of supercolossal California elephant garlic were $27.50, down from $30-32.50 last year.
Not everyone, however, thinks Chinese markets will strengthen. Bill Christopher, president of Gilroy, Calif.-based Christopher Ranch, said the country has too much product to ship for that to happen, though prices have dropped at a slower rate than he anticipated.
But the markets could remain stable if cold storage owners ship in an orderly manner, spread out over the whole marketing season, Christopher said.
"The cold storage owners aren't as anxious to dump garlic and get paid as farmers are," he said.
That said, there was still the chance of dumping — if Chinese shippers begin to notice quality issues, for example.
As for California product, Christopher was happy to see stable markets in September, and expected them to remain stable.
"A lot of retailers are sticking with California," he said.
Louis Hymel, director of purchasing and marketing at Orlando, Fla.-based Spice World Inc., shares Christopher's belief that California markets will remain stable. Chinese markets could go up and down in coming months, but they won't approach last season's sustained heights, he said.
Early shipments from Baja California and California were light because of bad weather, Auerbach said. Garlic from those growing regions also was smaller than usual.
Later California product is high quality but also is lacking in size, Auerbach said.
Rain-affected product harvested in July had worked its way through the system, and the California garlic shipping through the remainder of the season should be high-quality and of normal size, Christopher said.
The brisk movement of Chinese garlic in the second half of summer should bode well for California markets, too, Provost said.
"The bottom of the market won't be as low as it could have been," he said. "I expect the California prices to hold their ground."
Maurice A. Auerbach should begin importing garlic from Argentina in late fall, with light volumes expected in December and heavier volumes in January and February, Auerbach said.
After a big drop this summer, garlic prices stabilized in September, and some shippers said they could begin to tick up again.


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Roy Taylor, known to most industry insiders as the father of nVidia's ultra-successful The Way Its Meant To Be Played program – left nVidia to join MasterImage 3D. After spending 10 years at nVidia and going from developer relations to VP of Worldwide GPU sales, Roy decided to team up with MasterImage in order to drive the adoption of MasterImage's fantastic glassless 3D display.
MasterImage 3D patented cell matrix parallax barrier technology, i.e. dual-screen-in-a-single-LCD-screen technology that enables fantastic 3D effect without the need to use any glasses.
From my personal experience, nVidia's 3D Vision and its licensors [Panasonic] still offer the best 3D in the business, followed by MasterImage 3D, Dolby 3D and RealD. Everyone else doesn't even hold a candle, which is what we believe to be the key motivator for Roy's new course in an already examplary career.
Roy's official position is Executive Vice President at MasterImage 3D, LLC and General Manager, 3D Display. We'll closely follow the developments and see can MasterImage 3D create a TWIMTBP effect on 3D development community.
You can see how the technology works on MasterImage's official Autostreoscopic 3D page.


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found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already spayed, purebred, and up to date with shots.
Lilly, a Austin Pug dog was adopted! Here's how you can benefit by looking at adoption as an option to buying a Pug for sale in Austin, or seeking a Pug dog from a breeder in Austin.


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You may also like
Ratings for Dr. Abbas K. Ahrabi
I don't recommend him to anyone.I didn't understand few things and I asked the doctor. He was upset with my question. You can't believe this , he just walked away when I asked him the recovery time. Can you believe it ? I never had a bad experience in a doctor's office as today.
Dr. Abbas K. Ahrabi's response
We pride ourselves on doing our best to be responsive to our patients. A quick glance at what other patients are saying about us can attest to it. Please accept our apology if you truly have been our patient.
Submitted March 22, 2015
I have been going to Dr. Ahrabi for 4 years now. He has treated all my children, filled cavities, fixed cosmetic chips, root canal and crowns for my family members who were in dire need of a good dentist! He is thorough and gentle and explains all procedures and treatment. His staff was very friendly and insurance was explained so that I could understand my patient amount before starting the work. My kids (who had treatments), were happy and had painless shots and treatment. I will never go to another dentist EVER!! I recommend Dr. Ahrabi - Oakton Dental Center, to anyone that hates dentists!! He's simply awesome! Great work and Fantastic Doctor!
I strongly recommend him.I was there last week for the first time. I'm very particular about the dentist I see and found that he far exceeded my high expectations. For my first visit,that was awesome.
Dr. Ahrabi is probably the most thorough and knowledgeable dentist we have ever been to. We even changed our dental insurance so that we could continue seeing him. His staff is always friendly and helpful - they all seem to enjoy working with each other very much. I never wait more than a minute or two to be seen. I am always relaxed when I see him because I know he the best and my family is in good hands.
I had very bad Experience with this doctor for fillings and extraction.He will lets you know after he done the job.So much money minded.Before you go to this doctor be make sure to read reviews.I wont recommend this doc.
Dr. Abbas K. Ahrabi's response
Every possible effort whether it is verbal and/or written is made prior to any treatment to make a full disclosure of treatment to be done and patient's financial obligations. You could contact us to provide you a copy of what you agreed on in case you have lost your copy.
Submitted March 22, 2015
Extremely thorough, gentle, and knowledgeable about teeth. Excellent dentist.
Simply the best dentist in the area. He has addressed problems that my former dentist of 25+ years had ignored. Refers you to the best specialists in the area as needed.
All of the previous comments are right on. I too highly recommend Dr. A. He is kind, patient, professional,top-notch and a perfectionist. Nothing is more important to him than our teeth. A terrific find if you're looking for a dentist!! I too saw the dentist (since 1979)from whom he bought the practice. What a difference in care! LOVE HIM
Very knowledgeable, state-of-the art equipment, great at pain management, very comfortable surroundings. He has found/corrected problems with my teeth I never knew I had.
Dr. Ahrabi is the best dentist you will find in the area. A specialist in every area of general and cosmetic dentistry, and an all-around great person as well. He is very polite, professional, and on time. His office is clean and equipped with the latest technology.
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text:
North Muskegon Family Who Bought Stolen Dog Gets A New One
My mom tells me that every night in Detroit, on the news, there is another report of a dog that was stolen. People on the other side of the state are even breaking into locked cars to steal dogs that were left there, while their owner ran into a store or gas station.
Here on our side of the state one North Muskegon family purchased a dog online from Craig's List. They did it legitimately, or so they thought.


text:
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Solo® offers a selection of handheld and backpack sprayers — many of which are USA made — designed for everything from bleach to herbicides. Plus, shop GEMPLER'S for a wide selection of Solo sprayer parts that'll keep your sprayer operating at peak efficiency.


text:
A big change in direction is proposed for a building at a key downtown Monterey crossroads.
The three-story Paseo Del Alvarado Building at Del Monte Avenue and Alvarado Street has been home to ground-floor restaurants and upper-story nightclubs and offices since it was built in the 1970s in the city's first wave of urban renewal.
Most recently, parts of the upper floors housed the Hippodrome nightclub, until it was shut down by state alcohol control officials after a spate of fights and reports of public drunkenness.
Before that the building housed Club Octane and other nightspots, said city principal planner Kimberly Cole.
But now John Valenti wants to convert the upper-floor commercial area to 22 apartments, ranging in size from studio units to two-bedroom apartments.
"We're excited about it," Cole said.
The proposal, which will be heard by the Monterey Planning Commission at its Tuesday meeting, dovetails with city plans calling for more "mixed-use" development in the downtown.
The ground floor of the building is home to Cibo Ristorante, Taco Bell, a pizza parlor and a crepe restaurant. The upper floors are mostly vacant, Cole said.
"The building is at a crossroads, and it needs improvement," said project architect Henry Ruhnke. The owners don't see another nightclub upstairs as "a great idea" going forward, he said.
"It makes the most sense to look at a mixed-use concept," he said.
So far, there haven't been any hints of opposition about the idea. Ruhnke said he has fielded questions about water for the renovation, but that's not an issue.
"We have tons of water on this project," he said. Residential apartments would use far less water than a nightclub, he said.
All the apartments would be market-rate units because a recent court decision prevents the city from requiring apartments for below-market inclusionary housing, Cole said.
Larry Parsons can be reached at 646-4379 or lparsons@montereyherald.
com. If you go
·What: Monterey Planning Commission
·When: 4 p.m., Tuesday
·Where: Council chambers, 580 Pacific St., Monterey
If you go


text:
Hello again, this time i'm reviewing Pavilion DV7 from HP, configured as dvt-3105ea. Once again, my friend kindly lend his laptop to me (haha surprised how many good friends i have? it's easy : just let your friend copy your notes before exams haha)
sorry if i broke the rules, just stating i use it more than 6 hours consecutive gaming ( battlefield BC2 and others) although i didn;t own it.
this DV7 configured with i7 720 qm, 4 gigs of RAM, a large 500 gb hdd ( believe me, this is enough for accompplying you for your trip), and GT 230m ( enough for most game in mid settings. You won't want to maxxed everything in your trip anyway)
it could took BF: BC 2 and crysis 2 in HD ( 1366 one), mid setting in playable minimum fps. my friend didn;t have fraps installed so i can;t tell you the exact fps
my personal fave for this things is the style and multimedia. I mean, this is pavilion, a type of HP's created for your multimedia protables. a 17" HD screen wil do you lots of pleasure in watching movies, and LED display will save your battery. and by the way, it has quite "premium" aura, too. just in case you need some haha
i mean seriously premium aura. When i bring it, it actually looks like multimedia notebook rather than som e "other" notebook ( if you understand what i means)
The dv7-3105ea is a brilliant laptop for what is such a small price, with all the features its packs in, and its versatility, such as the graphics card not only being good for movies, (good on the 17 inch wide-screen) it is also very useful for more demanding games, while the processor isnt the best, it is more than enough for the average user, and its also good for a more gaming orientated user, having the 4gb ram is more than enough for current market games.
Overall i would recommend this laptop to anyone looking for power and performance, but have a budget! The overall design of the laptop should be enough to sway anyone who is faced with the decision of which laptop to choose, if you want simple and efficient this really is the laptop for you.
One bad point, is the battery, the battery on this laptop doesnt last the longest.
Some basic technical info:
- Processor: AMD Turion(tm) II Dual core mobile M520 2.30 GHz
- Installed memory (RAM): 4GB
- System type: 64 Bit
- Operating system: Windows 7 Home Premium
- Graphics: ATI Mobility Radeon HD 4530 series (512mb dedicated graphics)
- Screen size: 17.3 inches (Wide screen display - max res; 1600 x 900)
- Integrated webcam and bluetooth capabilities
- Sound: 3D Sound Blaster Pro compatible sound 16 bit integrated, Altec Lansing speakers with integrated sub-woofer
- Software: Microsoft Works and Microsoft Office Home and Student 2007 60-Day Trial Version, Microsoft Internet Explorer, Windows Mail, Adobe Reader, HP MediaSmart Suite, Windows Media Player, Windows Photo Gallery, DVD Play, Windows Movie Maker, Windows DVD Maker, Cyberlink DVD Suite, Windows Media Centre, HP Total Care Advisor and HP Games Console with hours of free game play.
Prices vary on this particular model. I've seen it as expensive as £900 in places! Whereas mine was just under £700. So, if you're thinking of buying this, the best advice I can give you is to SHOP AROUND! Ebay offer cheaper models of this, as does Laptops Direct although this may be ay a cost of less memory and a lower quality graphics card.
What I like about it:
The design:
The design is beautiful, sleek and black with a silver circular type pattern along the top. It's distinctive and unusual and the kind of laptop that you'd be proud to show off in public. The sleek, shiny surface does unfortunately have a tendency to attract fingerprint marks but I find this to be a common problem with most laptops these days. I didn't buy the laptop purely based on the stylish design but it's certainly a bonus and I recently found out this was a limited edition artists print which I didn't actually know when I brought it!
With a 17.3 inch widescreen, it's a big laptop. But I watch a lot of movies and play a lot of games on my computer so this is a bonus for me. I know some people prefer the smaller netbook types but if your a movie or game buff, it's a lot more enjoyable and easier to play/watch in wide-screen, in my opinion. The maximum resolution for this laptop is a huge 1600 x 900.
Gaming and films
This will play The Sims 3! Many notebooks these days are not powerful enough to handle The Sims and it's expansion packs but this laptop does and does so in a very efficent manner. As long as you play the game on lower graphic settings...I also play Zoo Tycoon 2, The Harry Potter games and Sonic The Hedgehog on this laptop. The large amount of RAM and dedicated graphics make this a dream gaming system and at a lot more reasoably priced than an Alienware gaming laptop, which will set you back at least £1,000!
The top of the laptop has dedicated media keys, including volume, start, stop, rewind and fast forward. It also comes with a separate remote control which also has these media keys on. This is useful for leaving the Laptop on a table and then watching a DVD whilst laying in bed or sitting on the sofa. It means you can control the DVD from where you sit, without having to get up and press play, stop etc on the laptop itself.
Everything about this laptop is fast! It's quick to turn on and start up, you can literally be logged on in less than a minute. This is much better than my previous laptops, even my £500 Acer took about 5 minutes to load. The internet is super fast too and since browsing the net is one of my favourite things to do, this is a major advantage for me.
I currently have several games, downloads, music and text files saved on my system yet there is still ample space for more, which is a good thing since I've just ordered yet more games in the January sales!
What I dislike about it
The laptop blows out a lot of hot air. You can feel it if its rested on your knee. This had me worried that one day, it would overheat and the fan would stop working. A quick Google search showed me that this was a common problem with this particular make of computer.
So I decided to invest in a cooling mat. I brought the 'Zalman - 17'' Notebook Cooler - 220mm Fan - ZM-NC3000S - Black' from Amazon, which wasn't cheap but effectively solved this issue of overheating.
Who I'd recommend it to
Movie fans and computer game fans, this is the perfect laptop for you! The 17.3 Widescreen is perfect for playing games and watching movies in stunning clarity. It can also be brought for a reasonably cheap price, if you shop around a bit first. I'd also recommend it to those who want a stylish laptop to show off and uni students who may need sufficient memory to store essays, research and dissertations on.
I haven't had a lot of luck with laptops but I've had this one since September and I've never had an issue with it. I love it. Perfect for gaming and movies, fast and reliable and stylishly designed and great value for money. I cannot fault it.
This Hp is one of the Artist limited Editon sets, with the smooth gloss finish.
As soon as you swicth it on , you do start to realize just how fast the bloomin thing is. Straight from the box it'll literally boot up in about 10 seconds!
The processor is not the only positive, though, with a huge 500 gig (half a terrabyte-no less!) on offer, not to mention a beautiful crisp LED backlit screen, making for the overall chasis to be as thin as possible whilst keeping overall power consumption to a minimum.
With The Hp Dv7 coming with Windows 7 (premium) pre-loaded , it makes web browsing a cinch, and is no exageration to say (at least) 8-9 web browser tabs could be opened simulataneously , even on a slow internet connection, and the laptop would still not slow down-impressive?
It comes as is standard , (as with most Hp laptops ) with Altec Lansing speakers, which are to my opinion some of the finest generic speakers seen on these shores!
Movie play back through the dvd,cd-r-rw, is stable and image and detail levels seem, conisitently sharp throughout.
With this having a i7, it does run effectively with a "quad-core" processor meaning this can and should be aimed at the more serious ethusiast, gamer, or video editor.
That sad you may just want to show off , and this certainly would be the bit of kit to do just that!
For the serious movie buff it is worth noting that is does come with a larger 17.3 inch widescreen display , by so doing maximises the overall cinema effect.
Whilst at university, I was given a grant to purchase a new laptop for my studies. Now this was an outrageous amount of money to give a student for a new laptop. You would think with it being a grant it would be a couple of hundred pounds at most but no - this was for £1000! So with this amount of budget I had the world of laptops at my peril. Having done my research regarding what you could get for my budget, I stumbled across the HP Pavilion Entertainment laptop. I am always a bit suspicious of those laptops that have keywords such as 'Entertainment' in the title as it makes you assume that that is their key function. As I needed a laptop for university, I was unsure if an 'Entertainment' laptop would be suitable. Oh boy, was it suitable!
I paid around £800 for my HP Pavilion and it was an absolute dream. It was quick to start up, had lots of free mini games such as bejeweled and solitaire which help to pass the time when you have writer's block! It is fantastic for internet use as it is so fast. It also has ample space for storing data. I had all of my university files and my 7000 word dissertation stored on the desktop along with loads of music files and it still ran as quickly as the day I got it.
Having needed to raise some funds after university, I sold my laptop and it is the biggest regret I have. I now share my partner's slow, unreliable laptop and every day I long for my fast, HP Pavilion! I loved this laptop and would highly recommend it to anyone. One word of advice though, once you have it, don't let it go! Other laptops just don't compare!
** Product Features **
* 17.3'' HD display
* NVIDIA GForce graphics
* HDMI port
* 500 GB hard drive
* 4 GB memory
* Intel Core i7 processor
* 5-in-1 memory card reader
* Integrated webcam with microphone
* LightScribe SuperMulti DVD drive
* Wireless connectivity
* Bluetooth
* Genuine Windows 7 Home Premium
** Technical Details **
Operating system: Genuine Windows 7 Home Premium (64-bit)
Processor: Intel Core i7 Processor i7-720QM, 1.6 GHz
Memory: 4 GB DDR3 (2 x 2048 MB)
Storage: 500 GB SATA Hard Disk Drive (7200 rpm), LightScribe SuperMulti DVD±RW with Double Layer Support, 5-in-1 memory card reader
Communication: Integrated 10/100/1000 Gigabit Ethernet LAN, 802.11 b/g/n; Bluetooth wireless networking, HP Pavilion Webcam with Integrated Digital Microphone, HP Mobile Remote Control
Display: 43.9 cm (17.3-inch) diagonal High Definition HP BrightView display, 1600 x 900 resolution
Video: NVIDIA GForce GT 230M, up to 2815 MB total available graphics memory, 1 GB dedicated DDR3
Sound: Altec Lansing speakers with integrated subwoofer, SRS Premium Sound
Ports: 4 USB 2.0, 1 HDMI connector, 1 eSATA + USB connector, 1 VGA port, 1 RJ45 ethernet connector, expansion port, 2 headphones-out, 1 mic-in, 1 FireWire IEEE 1394 port, consumer IR
Full size keyboard with integrated numeric keypad, Touch Pad with On/Off button and dedicated vertical Scroll Up/Down pad
Software: HP MediaSmart Suite, Windows Photo Gallery, Windows Media Player, Windows Movie Maker, Windows DVD Maker, Cyberlink DVDSuite, EasyBits Magic Desktop, HP Games Console (with some free game play), Microsoft Works and Microsoft Office Home and Student 2007 (60-Day Trial Version), Microsoft Internet Explorer, Windows Mail, Windows Media Center, Symantec Norton Internet Security 2009 (60 days live update)
Power: 120 W AC power adapter, 8-cell Lithium-Ion (Li-Ion) battery
Weight: 3.52 kg
Dimensions: 412.6 mm (L) x 277 mm (W) x 35 mm (min H) / 43.2 mm (max H)
** Price **
The HP Pavilion is available to buy from the following retailers:
Play.com - £909.99
Ebay - £550-£700


text:
In June 2009, we published a guide to genealogy blogging covering the hows and they whys and called it A Genealogy Blog Primer*. Today we're announcing an recent update which includes:
- updated information and hyperlinks to genealogy blogs
- an updated PDF file with large, easy-to-read type
- an updated slide show presentation
You can click here to download the PDF format of the primer.
In addition, the primer and accompanying slide show are available for use by genealogists and genealogical societies who want to use it in lectures and meetings to spread the good word about the joy of genealogy blogging. Please contact us at firstname.lastname@example.com for more information about utilizing this resource – for free!
* Everything You Ever Wanted To Know About Genealogy Blogging But Were Afraid To Ask!
©2010, copyright Thomas MacEntee


text: Revell Enamel Gloss Paint - 14ml - Revell 32107, This enamel black gloss paint 14ml from Revell is a highly versatile synthetic resin enamel paint ideal for model-users, hobbyists, crafts and schools - from woodwork to painting model trains. Supplied in a 14ml can, the enamel paint can be thinned with water, mixed with other colours and dries completely after 24 hours - a coat can also be overpainted after 4-6 hours. Exceptionally good on smooth surfaces and model kits, this gloss paint is also safe for the younger generation of hobbyists. Revell 32107 Enamel Black Gloss Paint 14mlCheck stock and price


text:
- Access to Resources 1236
- Active Advertising Systems 238
- Arts 244
- Audiobooks 51
- Banner networks 143
- Courses, Lessons 1559
- Databases 4607
- Design 2848
- Game Accounts 6072
- Minecraft Accounts 68
- Origin Accounts 1498
- Pokemon GO Accounts 6
- Steam Accounts 665
- Uplay Accounts 775
- Xbox Accounts 1289
- Others 332
- Gift Cards 285
- Hosting 161
- Invites 396
- iTunes & App Store 152
- Miscellaneous 1296
- Mobile Phones 1641
- Photos 1038
- Sports Predictions 218
- Templates 2568
PS4 Titanfall™ 2 (ENG)
Refunds: 0
Uploaded: 18.08.2017
Content: text (49 symbols)
|1000 $
|the discount is
|show all discounts
|10 $
|the discount is
Due to the increasing incidence of fraud attempts on the part of buyers, we strongly recommend you to record video from the time of purchase to the time of his check! (Your personal details in the video, you can hide / close).
In the absence of the video by the buyer, no claim!
After payment you will immediately receive the data from PSN account to install the game.
1. Click on this link: https://account.sonyentertainmentnetwork.com/login.action
2. Enter your email address and password that you previously purchased, and then click [Sign In] button.
3. Click the [Account]. In the left column, click [Media and Devices]. On the main part of the page, click on the rectangle [Game], and then press the [Disable all] button.
A warning! All further actions strictly with your console.
4. In the [Users] Create a new user and sign in as a new user.
5. In [PlayStation®Network] select [Register].
6. In the menu that appears, select [Use an existing account].
7. Then enter your login (example: email@example.com) and password (example: 111psn) that you have purchased, and move on to the system by activating the account as the primary.
8. After the menu appears the destination account [Sign In], and the user can log in to PlayStation®Network network using an existing account.
9. Enter the Playstation Store, and select [View uploaded files], to open the list of content located on your account, download everything, what you are interested in the background (no need to wait for a full load).
A warning! After loading the game - do not delete user! (In the case of the removal of the game will not work)
10. You go to your main account, and after all the downloads, you can safely play.
Additional information
Complaints received by the seller within 24 hours after the payment of the goods and only through the "Correspondence with the seller" on Oplata.info. Substitution is possible only in the following cases:
- Not a valid username / password;
- This product does not meet specification.
Please do not leave negative feedback without waiting for the seller to answer personal correspondence.
If you do not agree with the description of the goods please do not buy this product.
List of all of our products you can find on page: https://www.plati.com/seller/foombloom/597625
|1 month
|3 months
|12 months


text:
Pantene Pro-V Texture Sculpting Wax Reviews
disappointedI tried this product as a replacement for Redken Water Wax. I will be going back — 6 years agoLaurelJ | 153 reviews
Pantene Pro-V Texture sculpting WaxI know this is being discontinued, so I have bought 3 extras. I have short, somewhat spiked hair and love this product. I run it through my towel dried hair, put on my makeup, use a little gel, blowdry a couple of minutes and dab a little more of the wax on the tips and I'm out the door. I cannot imagine why this is being discontinued from the product line. — 6 years, 11 months agoabatemjg | 15 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 2 people said helpful
why discontinueThis is a great product-so why are you discontinueing? and where can I stil;l get some — 7 years, 2 months agojpcraft | 1 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 3 people said helpful
Great!I just got layers in my hair so i wanted something to make them stand out and this stuff does the trick :). You have to be a little careful about how much you use. Too much and you'll be stuck looking like a grease ball. And the smell is amazing :) — 7 years, 8 months agouknowwho90 | 39 reviews
nooooodon't like it too much my hair is thin and the hold for this product is way too strong hair gets stiff and won't move whatsoever i don't enjoy — 7 years, 8 months agoOona06 | 18 reviews
better than i expected!i stopped by the store today to get a pomade after getting my hair cut because i had bangs for the first time and they would not go the way i wanted them to. i've used a few other pomades before and they usually make the hair look kind of stringy and greasy but this product worked surprisingly well and has a STRONG hold without feeling stiff or greasy. what a pleasant surprise this product turned out to be — 7 years, 8 months agoeminatic | 28 reviews
Great waxI had my hair cut and styled one day at lunch by a different sytlist who unfortunately didn't know how to style it. Coming back to work it was soooo flat. I went and bought this wax and it was absolutely great. My hair was full of volume and bounce without being sticky. Just be careful not to use too much. So much for using my salon brand at $35.00 a pop. — 8 years, 11 months agofriendlysunshin | 42 reviews
not impressedI wasn't impressed w/ this product. I have very curly hair that tends to friz and this didn't help. Kinda gritty.. — 7 years, 8 months agoSUE1368 | 7 reviews
wowI love this stuff. It reaaly keeps my unmanagable hair in place. It's awesome — 7 years, 8 months agodbiehr | 1 reviews
Great productThis product works really well to give your hair some texture without weighing down or making it sticky. Works better than most expensive products that I have tried! — 9 years agomamichula | 4 reviews
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My Reasons for Reporting This


text:
In August I was in Berlin… for me it is a dream city! This city breathes art everywhere. In every neighborhood you get to see a street market, where anything is sold, like home-made food, paintings, fashion accessories, purses, sweets… Every street has something different, like a painted wall or door, a windowpane with flowers, a sculpture made of garbage, it's really a world of inspiration! I've been there for 10 days and it felt like it wasn't enough… Check out some of the many pictures I've taken.
By the way, I'm preparing a much more complete post about my trip to Berlin. Soon you'll get to see it at FOTOVIAJAR, a Portuguese web page about traveling from a friend of mine.
At the several street markets I visited, I had the opportunity of knowing the work of many artists that I didn't know of until now. Here are the websites of some of them:


text:
Prospective Study for Safety and Efficacy of InSpace™ in Rotator Cuff Tear Subjects
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Title: One-arm, international, multi-center with competitive recruitment, prospective study to assess the safety and efficacy of OrthoSpace's InSpace™ in rotator cuff tear subjects scheduled for surgery of the rotator cuff - A pivotal study
Device: OrthoSpace's Biodegradable Implanted Balloon (InSpace)
Study population: Rotator Cuff tear subjects scheduled for arthroscopy.
Number of subjects: Up to 70 subject for data analysis.
Number of sites: At least 4 sites in Israel.
Main Inclusion criteria: Informed consent, diagnosed with Rotator Cuff tear.
Main Exclusion criteria: Former surgery on affected shoulder, sever illness, significant shoulder co morbidities.
Follow up period: 12 months. Visits at hospital before discharge at 1-2 days post implantation, 7-10 days post implantation, 3 weeks post implantation, 6 weeks post implantation, 3,6 and 12 months post implantation.
Primary goal: To assess the safety of the SpaceGuard in Rotator Cuff tear subjects.
Secondary goals: To assess the effectiveness of the SpaceGuard in the study population. The effectiveness will be assessed by terms of good positioning of the SpaceGuard and subsequent follow-up non migration, surgeon satisfaction, pain relief and time to pain relief, Range of Motion (ROM) and time to ROM with the SpaceGuard.
Primary end point: Serious Adverse Event rate related to the device and/or system complication.
Secondary end points: Surgeon dissatisfaction following the deployment of SpaceGuard, migration of the balloon shown by ultrasound/ X-ray/MRI at relevant follow-up visits, lost of ROM and pain enhancement.
|Rotator Cuff Tear
|Device: SpaceGuard Balloon
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|One-arm, International, Multi-center With Competitive Recruitment, Prospective Study to Assess the Safety and Efficacy of OrthoSpace's InSpace™ in Rotator Cuff Tear Subjects Scheduled for Surgery of the Rotator Cuff
- The study's primary goal is to assess the safety of the SpaceGuard and implantation procedure, in the study population. Safety of the SpaceGuard will be assessed by reporting system related adverse events. [ Time Frame: 12-36 months follow-up ]
|Study Start Date:
|July 2009
|Study Completion Date:
|June 2014
|Primary Completion Date:
|April 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: SpaceGuard Balloon implantation
Device: SpaceGuard Balloon
Positioning of the balloon into the subacromial space between the humerus head and the acromion
Detailed Description:
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age 18 or older.
- Diagnosed with Rotator Cuff tear and are scheduled for surgery.
- X-Ray of treated shoulder with no unrelated pathology and imaging (ultrasound or MRI) showing Rotator Cuff tear.
- Persistent pain and functional disability for at least 4 months.
- Documented failure of conservative treatment.
Blood work up to two weeks before implantation as follow:
- Normal CBC
- Normal electrolytes (potassium, chloride, phosphorous, sodium)
- Absolute neutrophil count (ANC) ≥ 1,800 cells/mm3
- Platelets ≥ 100,000 cells/mm3
- Hemoglobin ≥ 10.0 g/dl
- Adequate renal function, with serum creatinine ≤ 2.0 mg/dl
- Adequate liver function, with serum bilirubin < 2.0 mg/dl
- Adequate liver function with SGOT/SGPT < 2.5 x the upper normal limit
- Normal values of the PT, PTT and INR tests
- Negative for HIV and Hepatitis B or C
- Mentally and physically able to fully comply with this protocol including adhering to follow-up schedule and requirements
- For Woman of Child Bearing Potential (WOCBP), negative pregnancy test and willingness to use birth control during the study.
- Singed Informed Consent Form.
Exclusion Criteria:
- Evidence of significant osteoarthritis or cartilage damage in the shoulder.
- Evidence of glenohumeral instability.
- Previous surgeries of the shoulder .
- Evidence of major joint trauma, infection, or necrosis in the shoulder.
- Patients unable to provide informed consent due to language barrier or mental status.
- Patients with a major medical condition that would affect quality of life and influence the results of the study (Including, but not limited to HIV, hepatitis, active malignancy in the past 5 years, transmural MI, CVA and other impaired neurological status, CHF or unstable angina in the past 6 months).
- Patients unwilling to be followed for the duration of the study.
- Acute infection requiring intravenous antibiotics at the time of screening.
- Other shoulder pain of unknown etiology.
- Paget's disease, osteomalacia or any other metabolic bone disease.
- Severe diabetes mellitus requiring daily insulin management.
- Bleeding disorders.
- Known cognitive disorder.
- Concurrent participation in any other clinical study.
- Physician objection.
- Subjects with sign of cervical root irritation.
- Chronic lung disease
- Trauma subjects
- For WOCBP, a positive pregnancy test.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00916994
|Wolfson Medical Center
|Holon, Israel, 58100
|Principal Investigator:
|Eliyahu Adar, MD
|Wolfson Medical Center
|Responsible Party:
|OrthoSpace Ltd.
|ClinicalTrials.gov Identifier:
|NCT00916994 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 7, 2009
|Last Updated:
|March 10, 2015
Keywords provided by OrthoSpace Ltd.:
Rotator Cuff Tear
ClinicalTrials.gov processed this record on September 21, 2017


text:
BLACK Country nature lovers are being urged to join the search for one of Britain's most important and endangered creatures.
Ecologists from the Canal and River Trust are taking to the tow paths for a survey to spot Great Crested Newts.
Scientist are encouraging members of the public to join in to help monitor and record the number and species of newts living at the Fens Pools Nature Reserve in Brierley Hill.
Keeping an accurate record of the variety of newts living at the pools will help to establish breeding patterns to help safeguard their habitats.
Newts are nocturnal and volunteers are needed to help with a torch light survey after dark, when they are most active.
The Great Crested Newt is the UK's largest newt and is legally protected, along with their habitats, as in the past their numbers have declined rapidly.
Canal and River Trust ecologist, Paul Wilkinson, said: "Newts are brilliant creatures and head back to the same pond each year to breed so it's important we make sure we look after their habitats so we can maintain a healthy newt population for many years to come.
"If you've never seen one before this is the perfect opportunity to get up close with these wonderful waterway dragons."
The Fens Pool surveys will be on Monday May 12 and Monday May 19, to reserve a place contact Paul Wilkinson on 03030 404040.


text:
The Jost Project Performs Classic Rock in a Jazz Format
Thursday, November 07, 2013
Where and When
Time: 7:30PM - 9:30PM
Location: Presser Music Room in the Music and Multimedia Center
Contact: firstname.lastname@example.com
Event Information
Hot after the recent release of their new CD "Can't Find My Way Home" (Dot Time Records), The Jost Project is made up of four talented local musicians. They are internationally renowned Tony Miceli, vocalist/harmonicist Paul Jost, acoustic bassist Kevin MacConnell and drummer Charlie Patierno. Devoted to interpreting rock-related "standards" in a contemporary jazz format, The Jost Project creates an exciting new connection between jazz and the music of the Beatles, Led Zeppelin, Aerosmith, Donovan, Simon and Garfunkel, the Beach Boys and others.
The event, sponsored by the college's Cultural Affairs Committee, will be preceded by a free master class open to the public.
The CD has been picked up by more than 60 college and jazz radio stations all over the country and receiving regular airplay. In addition, critics are raving in the US and Europe. Jazz in Europe's critic Johan van Deeg wrote …"The Jost Project is without a doubt one of the most creative bands I have heard for years. Blood, Sweat and Tears Music Director, Steve Jankowski said about Paul … "He was a stand out! I was captivated by his charisma and unique vocal style."
The master class takes place from 4:30 to 6 p.m. The concert gets underway at 7:30 p.m. Both events take place in the Presser Music Room in the Music and Multimedia Center on the campus at 275 Swamp Rd., Newtown, Pa., where there is ample free parking.


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SOUTH CHARLESTON, W.Va. — The state Division of Natural Resources says permit applications are now available for the limited bear firearms season this fall in West Virginia.
A bear season without dogs will take place from Nov. 24 through Dec. 6 on public and private land in 17 counties by permit only. The hunt is concurrent with the traditional firearms season for deer.
Residents aren't required to apply for a permit or buy a hunting stamp to hunt bears on their own land.
Applications are available at www.wvdnr.gov. Printed applications will be available late this month at hunting license agents, DNR district offices, the Elkins Operations Center and the DNR main office in South Charleston.
Completed applications must be mailed to the DNR by Aug. 18.


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>General Running>Ankle edema, Knee discomfort - Time for real shoes?
About a two years ago, When I ran - I ran barefoot. That did not last too long due to my feet being torn up by the concrete. Haven't run since until the Color Run Miami. A week before, I realized I needed running shoes. Went to Sports Authority (I think) and saw an awesome pair of Barefoot 3t running shoes. The 29.99 was within my budget and had myself a new pair of running shoes.
Now my body is experiencing some problems while I run - slight edema in the ankles and knee discomfort.Through the research I have done, I'm pretty confident that my weak ankles and weak arch's are to blame. Especially since I have sprained both my ankles several times when I was younger(soccer, skateboarding, rollerblading, stepping off a curb)
So yes - I need new shoes, and probably those nifty (sarcastic on nifty) little arch supports by Dr Scholls.I am a college student, and can not afford to spend tons of money on specially fitted shoes, but I do see the benefit.
Is there anything in between that someone could suggest? Is there a particular brand of shoe I should stay away from?Thanks in advance!
Fun Statistic:The probability of you reading this post is 1.00
Sub 30 5k, Sub 25 5k, Sub 50 10k, Win a 5k
>> I realized I needed running shoes. Went to Sports Authority (I think) and saw an awesome pair of Barefoot 3t running shoes.
You did not meet the need.
Save the money on the "nifty arch supports" and put that money into better shoes.
I get ankle edema at times. I run in minimalist shoes. Mine is, however, a side effect of a hypermobility disorder that I have, so my reason for it is probably different than yours.
Are you sure you're not running too fast for just coming back? Sure the shoe doesn't fit too tightly around the ankle?
I know the shoes that work for me, but this, well, varies wildly by runner. Arch support basically gives me cramps in my arches within 2-3 miles (I have high arches).
"When a person trains once, nothing happens. When a person forces himself to do a thing a hundred or a thousand times, then he certainly has developed in more ways than physical. Is it raining? That doesn't matter. Am I tired? That doesn't matter, either. Then willpower will be no problem." Emil Zatopek
Save the money on the "nifty arch supports" and put that money into better shoes.
Also, +1 to this.
I cant be running to fast. I did an easy 45 minute 4 mile run last night. As for distance - I don't think i'm pushing that either. Iv been running 5ks and finally pushed to a four mile run yesterday. As for the shoes - its an elastic band around the ankle. No discomfort there.
I suppose it doesn't have to be the shoes, but like I said, I don't think i'm pushing myself too hard in the slightest bit.
RA's cranky old teenager
If you want to get serious about running, you need properly fitted shoes. Save up about $100 and go to a specialty running store. Have them look at your gait and determine what kind of shoe you need. A good pair of shoes should last as much as 500 miles, sometimes more.
That's really the best way to go about it.
That's probably maybe mostly true.


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Health Cares About Domestic Violence Day Symposium on Oct. 10
Fairfax County Office of Public Affairs
12000 Government Center Parkway, Suite 551
Fairfax, VA 22035-0065
Contact: Merni Fitzgerald, Director of Public Affairs
703-324-3187, TTY 711, Fax 703-324-2010
Media Pager: 703-324-NEWS (6397)
Sept. 27, 2007
Health Cares About Domestic Violence Day Symposium on Oct. 10
In recognition of Health Cares About Domestic Violence Day on Oct. 10, the Fairfax County Domestic Violence Awareness Month Planning Committee and the Virginia Department of Health's Project RADAR will co-sponsor a symposium on improving the health care community's response to intimate partner violence.
The symposium will take place on Wednesday, Oct. 10, from 9 a.m.-2 p.m. in the Fairfax County Government Center Board Auditorium and Conference Center, 12000 Government Center Parkway, Fairfax. The free event is open to health care providers, allied professionals and the general public, but registration is required. The deadline for registration is Oct. 3.
The featured keynote speaker is Dr. Jacquelyn Campbell, the Anna D. Wolf chair in nursing at the Johns Hopkins School of Nursing and an internationally recognized expert on intimate partner violence. She will examine lethality risk factors for domestic violence victims through the use of her validated "danger assessment" instrument.
The event also features break-out sessions on screening and assessing for domestic violence in clinical settings; responding to the needs of victims with traumatic brain injuries; and an overview of the Inova Fairfax Hospital for Women and Children's Forensic Nurse Intimate Partner Violence Program and the Tahirih Justice Center's pro bono medical network.
For more information about the program and registration forms, visit www.fairfaxcounty.gov/dsm/ or contact Seema Zeya, domestic violence coordinator for Fairfax County, at email@example.com or 703-324-7472, TTY 711.
Project RADAR is an initiative of the Division of Injury and Violence Prevention at the Virginia Department of Health.
For more news and information, visit www.fairfaxcounty.gov/news.


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A market shift to smaller engines doesn't mean auto makers have lost interest in making great V-8s.
Judge Finlay fond of 420-hp 4.0L V-8 in Audi S7, which was not in 10 Best Engines competition.
No one ever recorded a hit song about a car with a small engine. "Hot Rod Lincoln," "409" and "Maybelline" glorified big V-8s, not 4-cyl. fuel-sippers.
OK, those tunes go way back. And even in those times, hordes didn't rush out and buy a muscle car just because a song about it made the top-40 charts. But those were the days for V-8s.
For reasons that include environmental consciousness, fuel economy and technological advancements, many consumers now opt for smaller engines.
Yet, that market shift doesn't mean auto makers have lost interest in making great V-8s. They continue to passionately engineer and improve them, as evidenced by the 2013 Ward's 10 Best Engines competition.
Three notable V-8s were in the running, and one made the top-10 list: the muscle-bound 5.8L that nearly lifts the Ford Shelby GT500 off the ground. It revs up to 662 hp and delivers 631 lb.-ft. (856 Nm) of torque at 4,000 rpm, with 395 lb.-ft. (513 Nm) of that just off idle.
Some judges wondered if the GT500's supercharged engine might overwhelm anyone other than a professional driver. "Can there be too much power?" asks WardsAuto Editorial Director David Zoia.
Ultimately, WardsAuto judging concluded the world's most powerful production V-8 also ranks as world-class in more than just output.
Two other performance V-8s also drew high praise, although they didn't make the final cut: the 6.2L supercharged beast in the Chevrolet Camaro ZL1 and the 5.0L power-tripper in the Ford Mustang Boss 302 Laguna Seca, aptly named for a California racetrack.
A great engine is a great engine, large or small. Some detractors think high-output V-8s belong in Jurassic Park. Not so. They're alive and well. But they have become specialized, appealing to a niche market of driving enthusiasts. Cue the music though; they're still worth singing about.


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Nothing keeps you busy throughout the summer like building another simlab! Presently we are about a month away from being totally set up. The plan is to separate the Laerdal and METI equipment to better streamline activities and also to better take care of our growing demand from the different programs we assist. We've simply needed more space for our growing program. So SimMan, SimBaby and Nursing Anne are now on the next floor up in a new lab which also houses our new office and second control room.
We'll also now have a place to run our Heart Code ACLS certification package. This is a certified ACLS learning and testing program that allows folks to sign up and run through the ACLS tests over multiple hours. It's a very well conceived program that actually does a lot of the work over the internet. When a student passes – it sends the info to the American Heart Association and they send the student their ACLS certification card! We will officially launch this in the fall of 08.
Other pieces coming together in the new rooms include:
1. New control room with control of 4 cameras, Hi-definition possibilities and control of SimMan and SimBaby.
2. Video and audio mixers for pre and post production.
3 . AVS streaming video server linked to classrooms at UNE.
4. A front desk, waiting area, new shelving and WINDOWS WITH A VIEW!
5. Hospital and ICU type headwalls with air pumped in to simulate oxygen and suction.
6. New blackout shades to control the light.
7. Two way mirror for viewing from office to lab.
With the expansion to the upstairs it's creating more room for our 2 METI HPS simulators and the anesthesia machines in our downstairs labs.This installation is happening soon too. The virtual OR and ER are getting a little more "real."
Big/Little purchase: Well, we bought a Gaumard pediatric HAL simulator and we love him! He is my new favorite simulator to use for those impromptu demos that happen in the summer! He can be turned on in 1 minute and with his totally wireless capability, blinking eyes, superior sounds and pulses… he is a hit already.
We've already used him in our hallway for a few scenarios and have plans to do a larger scale simulation with SMCC's CCEMT program, ER residents and possibly passers by. I predict that Gaumard will sell alot of these simulators and so far I am totally impressed with the fidelity, usability and medical validity of this kid. Looking for a new simulator? Check out Gaumard. They are rising fast.
So many tasks still remain but progress is happening. This next year looks to be our busiest yet and with the planning we've done it should be our most successful. We'll probably have some type of open house for the new simlab soon and will probably post pictures in the next blog.
Stay Tuned.


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Longer-Dated Treasuries Strengthen
Longer-maturity U.S. debt strengthened through the afternoon today as a debt-ceiling deal appeared close at hand, meaning the U.S. should be able to dodge default until the next debt-ceiling standoff, which per the terms of the deal will likely be in January or February. The ten-year Treasury celebrated this can-kicking by gaining 14/32 in price on the day, trimming its yield to 2.669%, per Tradeweb data, while the 30-year bond gained 31/32 to yield 3.722%.
What sort of U.S. debt did not post gains on the day? T-bills, of course. Tradeweb has the 3-month, 6-month and 1-year T-bills all losing ground on the day, after doing the same yesterday and having a generally bad month. Until this debt deal is signed and sealed, investors (namely money-market funds) remain wary of any U.S. debt due to mature soon, which would be first in line not to get paid back in the event of a default.


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Oscars 2013 – Part 2
Right on the heels of Part 1 of my Oscar post comes Part 2! Here's the "Argochoke Dip: Go Cluck Yourself", which I posted about a few weeks ago. This was a big hit. We had a couple vegetarians at the party, but no other vegans. In case you'd be worried to serve this to [...]Read more


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THEMED free play days including sports, games and swimming will be taking place at St Michael's School in Minehead this summer.
Hot and soft drinks will be available but parents are asked to take a picnic with no fizzy drinks and swimming gear and towels.
There's an Australian-themed day on August 7 and a country gardens theme on August 14. Each play day takes place from 11am-3pm – details from Shelia Scott on 07814-006527.


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Electricity comes at a cost. There's simply no getting around that problem (short of installing your own solar panels, of course). However, that doesn't mean that you have to be stuck with high power bills. There are several ways that you can reduce the amount of your electricity cost – and they don't necessarily involve turning off your air conditioner in the middle of summer, either. Here are some excellent ways to knock those costs down.
Get a Smart…Continue
Added by David Adam on November 18, 2013 at 11:54pm — No Comments
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Place six marker discs in a circle around the basket, each at a distance from the pole approximately 5 meters (for novice), 7 meters (for intermediate) or 9 meters (for advanced). Starting at any marker and moving around the circle one marker at a time, putt three discs at time from each marker. Proceed with play as follows:
A) If all three putts are made, move that marker disc away from the basket approx.1 meter and proceed to the next marker.
B) If all three putts miss, move that marker disc toward the basket approx.1 meter and proceed to the next marker.
C) If one of the first two throws was made as well as the third throw, you get a bonus re-throw from the same location.
D) For all other results, leave that marker disc in the same location and proceed to the next marker.
When all three putts have been made from a marker 8 meters (for novice),10 meters (for intermediate) or 12 meters (for advanced), that marker is removed from the game. The goal is to see how many "rounds" it takes until all markers are removed (or simply play until allotted time is up).


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Education is a high priority for any university, but at Columbia, it is center stage. For example, research fellows have the opportunity to learn methodology and analytical skills from experienced Faculty with the highest caliber of expertise. They have access to some of the best minds in psychiatry in the country, and many would say in the world. All of our Research Faculty are highly invested in ensuring that we provide the best training, the best research opportunities and the best preparation for making landmark contributions to science. We understand that our research trainees are the future of Columbia and of psychiatry and we strive to prepare them to be the scientific leaders of tomorrow, today.
— Melissa Arbuckle, MD, PhD
The NIMH-funded Behavioral Sciences Research in HIV Infection Training Program provides innovative postdoctoral training in sexuality research applied to HIV prevention science.
This is a two to three year fellowship in clinical and basic research on the psychiatric disorders of older adults, including Alzheimer's Disease, late-life depression, late-life anxiety disorders, and late-life psychosis. It is supported by a NIMH grant, and offers didactic methodological and statistical training as well as a supervised research experience.
This is a two to four year fellowship in clinical and basic research on affective, anxiety, eating, personality, memory and dual diagnosis disorders, including psychobiological, nosological and psychopharmacological studies. It is supported by a NIMH grant, and offers didactic methodological and statistical training as well as a supervised research experience.
The research training program, Developmental Neuroscience and Behavior (formerly known as Research Training in Psychobiological Sciences), is an NIMH-funded postdoctoral program for MDs and PhDs that focuses on the interplay of psychological and biological processes as these contribute to new knowledge about the etiology of clinical disease.
This fellowship focuses on research strategies, basic and clinical, related to schizophrenia. Supervised research, training in statistics and research methodology, and didactic seminars on schizophrenia comprise the two to four year program, which is supported by a National Institute of Mental Health (NIMH) grant.
The Paul Janssen Fellowship is awarded to an outstanding young physician-investigator (must have M.D. degree) to conduct novel translational research in the field of neuroscience as it relates to psychiatric disease and medicine.
This two year post-doctoral program trains M.D. and Ph.D.s for clinical and human laboratory research careers in many areas of substance abuse.
NIMH funded postdoctoral training fellowships are available to child psychiatrists, psychiatrists, neuroscientists, and psychologists to conduct translational research in childhood psychiatric disorders.
The program provides social scientists, epidemiologists, psychologists, and psychiatrists with research skills in psychiatric epidemiology.
NIMH has funded this Career Opportunities in Research (COR) program to strengthen research and research training experiences in scientific disciplines related to mental health, especially at four-year undergraduate institutions serving mostly underrepresented minority students.
The goal of the GCD program is to train postdoctoral (M.D. and Ph.D.) and predoctoral fellows in genetic epidemiology and statistical analysis of psychiatric and other complex diseases.
The Global Mental Health Research Fellowship at Columbia aims to develop independent clinical scientists who can work collaboratively across disciplines and cultures in order to respond to the substantial burden of mental health related diseases in low- to middle-income countries and resource-limited areas. This program combines didactic instruction, clinical research training, and mentored clinical research experiences in global settings.
This three-year post-doctoral program trains MDs and PhDs for clinical research careers in eating disorders.
Selected Columbia Psychiatry Department faculty members provide supervision for our various Research Training programs. View a complete list of our Psychiatry Department Faculty.


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Croatia Trips
Encompassing an arc of geographically complex territory between the Balkans, Central Europe, and the Mediterranean Sea, Croatia is a deeply cultural place blessed with a myriad of striking natural settings.
The Dinaric Alps run through its heart, climbing skyward with starkly beautiful karst rock formations, mist-swathed peaks, and an extensive system of gorges, canyons, and underground caves. By contrast, the country's rambling coastline is home to warm turquoise waters and more than 1000 sun-drenched islands. Almost 50% of the country is covered with forests, but you'll also find scrub, wetland, grassland and bogs. Croatia boasts are over 400 protected areas – including 8 national parks – affording plenty of opportunity to hike, bike, or commune with nature.
Bordering the nations of Slovenia, Hungary, Serbia, Montenegro, and Bosnia Herzegovina, Croatia represents a cultural and geographic crossroads. Historians trace the region's tribal beginnings to the Liberunians and Illyrians, who were subjugated by the Romans in 168BC. Croats did not arrive in the region until the 10th century AD, when they established the medieval Kingdom of Croatia. Throughout the middle ages, Croatia maintained a personal union with Hungary, prospering as a centre of trade, culture, Christianity, and learning.Read more
Today, the legacy of Central European contact is particularly marked in Croatia's central and northern regions, where rambling cobble-stone towns, grand cathedrals, opulent mansions, and commanding hill-top fortresses are a monument to an era filled with imperial elegance and power. Nonetheless, Croatia's golden age was marked by subjugation – its national consciousness did not begin to awaken until the 19th century, when the Illyrian movement sparked a revival of the Croatian language and bold new developments in art and literature.
The movement, which advocated the unity of all Serbs, was particularly dynamic along the Croatian coast - an area that has historically benefited from prolonged contact with the culturally enlightened state of Venice. The Venetian legacy includes a plethora of well-groomed parks and elegant townhouses, renaissance palaces and bustling civic squares.
In 1918, Croatia joined Slovenia and Serbia to form the short-lived Kingdom of Serbs, Croats, and Slovenes, which would later become Yugoslavia. After the Second World War, Yugoslavia was incorporated into the USSR, achieving emancipation only after the fall of communism. In 1991, Croatia made a bid for autonomy, declaring itself independent and sparking a bitter four-year war with neighbouring Serbia. It emerged victorious in 1995.
Today, Croatia is a model post-Soviet state. Scheduled to join Europe's single currency in 2013, it is one of the freest, most prosperous and democratic nations on the continent – a place celebrated for its theatre, art, music, literature, sports, and cooking.
Places of interest in Croatia
A formidable rival of Venice during the middle ages, Dubrovnik enjoyed special prosperity thanks to vigorous maritime...
Korcula is the second most populous island in Croatia's central Dalmatian archipelago, a place renowned for its...
Evolving through Greek, Roman, and Venetian phases, the historic port of Trogir boasts more than two millennia of...
Zagreb is the stylish and cosmopolitan capital of Croatia, home to almost a million inhabitants and a quarter of the...
Activities in Croatia
Other Countries
- Albania
- Andorra
- Austria
- Azores
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- Jersey
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- Lithuania
- Macedonia
- Madeira
- Mallorca
- Malta
- Moldova
- Montenegro
- Netherlands
- North Cyprus
- Norway
- Poland
- Portugal
- Romania
- Russia
- Serbia
- Sicily
- Slovakia
- Slovenia
- Spain
- Sweden
- Switzerland
- Turkey
- Ukraine
- United Kingdom


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New "Loki - God of Mischief" film clip...
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In this brand new video clip from the upcoming animated feature THOR: TALES OF ASGARD, Loki plays a prank on the wolf Fenris in the Port Hole Pub while Thor and the Warriors Three look on.
[ame="http://www.youtube.com/watch?v=jKE8PXCq718"]THOR: TALES OF ASGARD[/ame]
THOR: TALES OF ASGARD debuts on Blu-ray Combo Pack (SRP $29.99), DVD (SRP $19.98) and Game Consoles from Marvel Animation and Lionsgate Home Entertainment on May 17, 2011.
Before he ever lifted his mighty hammer, there was the sword. Fantastic journeys beckon from the mysterious nine realms. Places of dark mists and fiery voids. Of winged creatures and giants in the ice. And the most alluring quest of all the search for the legendary Lost Sword of Surtur. Hungry for adventure, Thor secretly embarks on the journey of a lifetime, joined by his loyal brother Loki, whose budding sorcery equips him with just enough magic to conjure up trouble, along with the Warriors Three a band of boastful travelers reluctant to set sail on any adventure that might actually be dangerous. But what starts out as a harmless treasure hunt quickly turns deadly, and Thor must now prove himself worthy of the destiny he covets by saving Asgard itself.


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Bruce Flanders - perhaps the most recognizable motorsports voice in Southern California - will be back on duty this weekend at the Toyota Grand Prix of Long Beach, with the same goal in mind.
"Public address announcers are to entertain the fans," said Flanders, who has been part of the Long Beach festivities for 36 of the 39 years. "I'm speaking to the person there for the first time, who got tickets from his boss.
"That's who I'm trying to convert."
The 67-year-old Flanders has won more than his fair share of converts. He's been calling events since 1969.
"Several years ago, I met a doctor in Riverside," said Flanders, who has been diagnosed with COPD since 2008. "I introduced myself and he said he recognized me by my voice. 'I first heard you when my dad took me to Costa Mesa (speedway bikes) when I was 12,'he said."
Flanders, a Vietnam veteran, once worked 104 racing events in a year (with the winter months off). In addition to Long Beach, Flanders can also be heard this year at Irwindale Speedway, Pirate Speedway in San Bernardino and City of Industry speedway bikes.
Calling the action at Long Beach is unique. Because of the numerous large screens around the city course, he's describing the race for those who can view the screens.
"Basically calling a TV show for a live audience," he said. "It wasn't always that way. I didn't get my first TV monitor until the early 1980 s.
"That changed the way we announced."
Flanders, whose sense of humor is as legendary as his voice, has overcome COPD through physical activity. At one point, his future looked bleak, but he's now a testamental to his work ethic.
"My oxgyen provider (Inogenone) has given me added mobility," said Flanders, who will be on the mike for more than 36 hours in three days. "I'm looking forward to the weekend."
France sets standard
NASCAR Sprint Cup driver Brad Keselowski ripped into the sanctioning body after Saturday's race in Texas, saying Penske Racing was unfairly targeted. In light of the fine against Denny Hamlin earlier in the season, many expected the same for the defending champion.
No so fast, said NASCAR Chairman and CEO Brian France, who said there would be no fine.
"That's the beauty of NASCAR - we do allow the drivers to express themselves in that way, even if they say things that we would disagree with," France told Fox Business network. "And I would certainly disagree with everything that he said.
"The line that we draw is that you can't criticize the racing product. You can criticize our decisions, you can criticize everything else, which is more than any other sport might allow. But just don't go talking about our racing product isn't the best in the world, because it is."
However, rules violations are another matter.
Both Penske drivers, Keselowski and Joey Logano, were fined 25 points and crew chiefs (Paul Wolfe, Todd Gordon) fined $100,000; car chiefs (Jerry Kelley Raymond Fox) and engineers (Brian Wilson, Samuel Stanley) all suspended for six races for rear-end suspension violations.
IndyCar notes
Dario Franchitti, a four-time IndyCar champion, will make his 250 th start at Long Beach. He's won 31 races (including three at the Indinaopolis 500) and finished second 29 other times in 15-plus seasons. Mario Andretti holds the record at 407 starts. ...
Mike Conway was a surprise winner in 2011 and will be back in action this weekend. He's in a one-off race for Rhal Letterman Lanigan Racing. ...
Will Power is the defending champ. In IndyCar, just Andretti, Sebastien Bourdias (a three-time winner), Paul Tracy, Al Unser Jr. and Alex Zanardi have scored consecutive wins at Long Beach. ...
Marco Andretti, Mario's grandson, has a pair of top-10 finishes this year. With two top-five finishes in three starts, he appears to be in line to extend his family's mastery on the streets. Mario and Michael, his father, have accounted for five wins.
Local news
Pirate Speedway, formerly known as IMS Speedway in San Bernardino, opens its 2013 season Friday night with Larry Huffman announcing speedway motorcycles and two-person speedway sidecars. Racing begins at 8 p.m. ... Perris Auto Speedway will host the second round PASSCAR Stock Car Championship Series, with a $1,000 American Factory Stocks, Modifieds, Super Stocks, Sport Mods and the CDCRA Dwarf Cars. ... Les Richter, who helped Roger Penske construct California Speedway and was general manager at Riverside International Raceway, has been renominated for the NASCAR Hall of Fame Class of 2014. ... NHRA Super Gas racer Derek Sanchez, from Yuma, Ariz., passed away April 11, five days after a high-speed crash at the SummitRacing.com NHRA Nationals at The Strip at Las Vegas Motor Speedway. ... Thursday Night Drag Racing at Irwindale Speedway, with a cost of $20 per vehicle and $10 to watch the action from 5 to 10 p.m.


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Update: We've made it to 100,000! The iPhone app (both in Standard and HD flavors) is now available for free on iTunes and will remain so for a week!
At this year's QuakeCon, we announced that if we reach 100,000 fans on Facebook, we'd make RAGE/RAGE HD for iOS free for a week. As of this very moment, we're at 97, 066 fans, so be on the lookout for the app going free very soon!