text:
2009 AHL All-Star Classic presented by Charter Communications – DCU Center – Worcester, Mass.
Last Week's Results
Welcome Home: Grand Rapids, which maintains second place in the North Division with a 25-9-6-3 record and 59 points, will commence a season-high five-game homestand on Wednesday against the Toronto Marlies, followed by a Friday-Saturday set versus the Quad City Flames. The Griffins, who have earned points in 20 of their 23 home games thus far (14-3-3-3), sit just one point behind first-place Manitoba (60) with one game in hand, and five points ahead of third-place Hamilton (54).
Nice to Meet You, Mr. McCarty: Prior to this Saturday's game against Quad City, four-time Stanley Cup champion and current Detroit Red Wings forward Darren McCarty will sign autographs for fans from 6-7 p.m., thanks to Aquinas College. The Red Wings' own Karen Newman will also perform the national anthem prior to the game. In addition, the first 2,000 fans will receive Griffins rally towels, courtesy of Aquinas College, and fans can bring their skates and take to the ice for the post-game open skate.
Friday Fun: This Friday's game against Quad City will mark another Dollar Beers, Dollar Dogs night, with $1 hot dogs and $1 domestic drafts available from 6-8 p.m. while supplies last, as well as College Night and Library Night ($10 lower-bowl ticket with student I.D. or library card). In addition, the first 1,500 kids will receive a Griffins player card strip, which features Justin Abdelkader, Mattias Ritola, Francis Pare, Jason Jozsa and Jan Mursak.
Winning Wednesday: All fans who were in attendance for the Griffins' 6-5 shootout win over Rockford on Jan. 7 can redeem their ticket stub for a free ticket to this Wednesday's game against Toronto. Redemption can be done in advance at The Zone, or on game night at the Van Andel Arena box office. In addition, if Grand Rapids defeats the Marlies, all fans in attendance can redeem their ticket stub for a free ticket to the game on Wednesday, March 4 vs. Toronto. Also, Douglas J will present "Hockey in Heels," with free armchair massages on the concourse and giveaways of spa treatments and products throughout the game.
Home Sweet Home: The Griffins' recent nine-game home point streak (7-0-2-0 from Dec. 17-Jan. 10), which was snapped by Friday's 6-4 loss to the Moose, was their longest since a 10-game run (9-0-0-1) from Feb. 18-April 14, 2006…Grand Rapids has lost only three of its 23 home games during regulation (14-3-3-3 at Van Andel Arena).
Keep On Rollin': Grand Rapids' 0.686 winning percentage is tops in the North Division, second in the Western Conference (Milwaukee – 0.690) and third in the AHL (Hershey – 0.705)…The Griffins have points in 22 of their last 26 outings overall (17-4-4-1) overall…Grand Rapids is only six wins and 11 points shy of the totals earned by its 2007-08 brethren…The Griffins' 59 points are tied for their third-most ever through 43 games (68 in 2000-01, 61 in 2005-06, and 59 in 1999-00).
Cold-Blooded Killers: The Griffins recently held 11 consecutive opponents without a power play goal (Dec. 27-Jan. 17), smashing the previous franchise record of nine straight games set from Nov. 19-Dec. 6, 2003. A power play goal by Rockford's Petri Kontiola during the second period on Wednesday snapped that streak, as well as the Griffins' run of 43 consecutive opponent power plays killed that fell two shy of the team record (45, Nov. 15-Dec. 10, 2003). That recent success propelled the Griffins into first in the AHL's penalty killing rankings at 88.9%. Grand Rapids has allowed league lows of 22 power play goals overall and eight power play goals at home, while denying an AHL-high 92.8% of its visitors' chances. In their previous 12 seasons, the Griffins have never finished higher than fourth (2000-01 IHL) or above 87.0% (2003-04) in penalty killing.
Better Late Than Ever: The Griffins' nine regulation losses remain the fewest in the AHL, but their nine defeats past regulation time (6 OTL, 3 SOL) are the most in the league and their league-high six overtime losses have tied a franchise record set in 2006-07.
GR's Stars Set to Shine: Griffins defenseman Jakub Kindl and goaltender Daniel Larsson have been selected to play for the PlanetUSA AHL All-Star Team at the 2009 AHL All-Star Classic presented by Charter Communications, which will be held this Sunday, Jan. 25 and Monday, Jan. 26 at the DCU Center in Worcester, Mass. Kindl was chosen as a starter via on-line fan balloting at theahl.com, while Larsson was selected as a reserve by a committee of AHL coaches. Kindl is the sixth Grand Rapids defenseman in eight years to be selected to play in the AHL All-Star Classic, joining Jonathan Ericsson (2008), Derek Meech (2007), Niklas Kronwall (2004-05), Travis Richards (2004) and John Gruden (2002). Larsson becomes the ninth Grand Rapids goaltender in 13 years to be chosen to play in an all-star game, following in the footsteps of Jimmy Howard (2008), Joey MacDonald (2005), Marc Lamothe (2003) and Martin Prusek (2002) in the AHL, and Mike Fountain (2001), Jani Hurme (2000), Ian Gordon (1998) and Pokey Reddick (1997) in the International Hockey League. Kindl and Larsson will be joined at the 2009 AHL All-Star Classic by three former Griffins, including forward Alexandre Giroux (Hershey) and defensemen Bryan Helmer (Hershey) and Danny Syvret (Philadelphia) of the Canadian AHL All-Star Team.
Watch it Live: Fox Sports Detroit PLUS will televise both the AHL All-Star Skills Competition (Sunday, Jan. 25 at 4 p.m.) and the AHL All-Star Game (Monday, Jan. 26 at 7 p.m.) live throughout Michigan. West Michigan providers include Comcast (ch. 901), Charter (ch. 88), AT&T U-verse (ch. 738), DIRECTV (ch. 664) and Dish Network (ch. 499 for All-Star Skills Competition, ch. 448 for All-Star Game).
Player of the Week Nominee: The Griffins on Monday nominated goalie Jimmy Howard for the Reebok/AHL Player of the Week award, after he went 2-1-0 with a 2.14 GAA and a 0.925 save percentage in three games. Howard has allowed two or fewer goals in six of his last nine outings.
Howard's High Notes: On Saturday in Rockford, Jimmy Howard surpassed current New York Islander Joey MacDonald as the Griffins' all-time leader in goalie games played (now 165 to MacDonald's 164) and joined MacDonald as the only goalies in franchise history to reach 80 wins. Howard also recently took over the number one spot as Grand Rapids' all-time leader in goaltender minutes played (now 9,412:09 to MacDonald's 9,208:13), and is getting ready to pass his old teammate as the leader in numerous other categories. He currently ranks second all-time to MacDonald in saves (4,251 to 4,208, 43 away), wins (88 to 80, eight away) and shutouts (16 to 12, four away).
Grand Larssony: Daniel Larsson's five shutouts are tied for first in the league and are within one of the Griffins' single-season record. Larsson's five shutouts were earned from Nov. 11 to Jan. 10, as he joined Joey MacDonald as the only Grand Rapids netminders to log five shutouts in a two-month span. Larsson, who also ranks among the AHL's leaders with 14 wins (14-5-1, T11th), a 2.42 GAA (T7th) and a 0.921 save percentage (7th), is 12-3-1 with a 2.05 GAA, a 0.933% and those five shutouts over his last 18 outings.
Honor Roll: Evan McGrath has notched a point in 13 of his last 18 games (5-9—14)…Francis Pare, who enjoyed his second three-point night (2-1—3) of the season last Friday, has points in 12 of his last 17 games (10-9—19) and seven goals over the last 11 contests…Mattias Ritola's six-game point streak (4-4—8) was snapped on Saturday, but he has lit the lamp in five of the last 10 games (5-4—9)…Darren Haydar has registered points in 15 of the last 20 games (7-11—18)…Ville Leino has eight points (2-6—8) over the last seven games.
Take Me to Your Leaders: Several Griffins rank among the AHL's individual leaders: Justin Abdelkader – T14th rookie points (25); Darren Helm – T6th shorthanded goals (2); Jimmy Howard – 15th GAA (2.53), T9th shutouts (2); Jakub Kindl – 5th defenseman points (26), T1st defenseman game-winning goals (2); Daniel Larsson – T1st shutouts (5), T11th wins (14), T7th GAA (2.42), 7th save percentage (0.921); Ryan Oulahen – T4th shorthanded assists (2); and Francis Pare – T12th rookie points (26), T6th in rookie plus/minus (+12), T7th rookie game-winning goals (2).
Milestones: Ryan Oulahen has appeared in 272 games as a Griffin, just eight behind fifth-place Dave Van Drunen on the franchise's all-time list (280)…Garrett Stafford appeared in his 400th pro game on Jan. 9 and his 400th AHL contest last Wednesday in Hamilton…Darren Haydar is just one point shy of 500 as a pro (187-312—499) and nine points away from 500 in the AHL (186-305—491)…Francis Lemieux's next game will mark his 200th professional and AHL contest…Aaron Downey was assessed his 1,400th penalty minute in the AHL last Friday against Manitoba.
Come One, Come All: The Griffins stand fifth in the AHL with an average attendance of 6,533, a year-to-date increase of 13.1% over the first 23 home contests of 2007-08 (5,775). The team's total attendance of 150,261 is its highest through 23 home games in six years, since the 2002-03 campaign (155,145).
Blanks for the Memories: Grand Rapids has shut out five of its last 15 opponents overall, including four of the last eight at home, and now shows seven shutouts on the season, just three shy of the franchise standard set in 2003-04. The Griffins' recent domination has moved them into third in the AHL in goals allowed (2.63 per game).
Scouting Report
Wed., Jan. 21 vs. Toronto Marlies (21-16-1-5) – Van Andel Arena – 7 p.m.
Fri., Jan. 23 vs. Quad City Flames (16-18-5-3) – Van Andel Arena – 7 p.m.
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text:
Impact of HIV and Its Treatment on Reverse Cholesterol Transport
This study has been completed.
The Alfred
National Health and Medical Research Council, Australia
Information provided by (Responsible Party):
Jennifer Hoy, The Alfred
ClinicalTrials.gov Identifier:
First received: September 9, 2005
Last updated: January 19, 2012
Last verified: January 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
To investigate the effect of treatment of HIV infection with highly active antiretroviral therapy on individual steps of reverse cholesterol transport, endothelial function and intima-media thickness in HIV patients.
|HIV Infections
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Impact of HIV Infection and Treatment With Highly Active Antiretroviral Therapy on Reverse Cholesterol Transport
Resource links provided by NLM:
MedlinePlus related topics: Cholesterol HIV/AIDSU.S. FDA Resources
Further study details as provided by Jennifer Hoy, The Alfred:
|Study Start Date:
|June 2005
|Study Completion Date:
|March 2011
|Primary Completion Date:
|September 2010 (Final data collection date for primary outcome measure)
No antiretroviral therapy for 12 months
Initiating ARV therapy with an NNRTI based regimen
Initiating ARV therapy with a PI based regimen
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
HIV infected patients naive to ARV therapy
Inclusion Criteria:
- Male patients with HIV infection (3 groups of 50 patients each)
- HIV infected patients, naïve to ARV therapy and not likely to need to commence therapy for the duration of follow-up (12 months)
- HIV-infected patients, PI naïve, initiating therapy with PI-containing HAART (ARV naïve or NNRTI experienced changing to PI regimen)
- HIV-infected patients naïve to ARV therapy, initiating NNRTI-containing regimen
Exclusion criteria
- Treatment with any form of lipid lowering drugs, including fish oils.
- Body Mass Index greater than 27.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00168233
Please refer to this study by its ClinicalTrials.gov identifier: NCT00168233
|Australia, Victoria
|Alfred Hospital and Baker Heart Research Institute
|Melbourne, Victoria, Australia, 3004
Sponsors and Collaborators
The Alfred
National Health and Medical Research Council, Australia
|Study Director:
|Dmitri Sviridov, Dr
|Baker Heart Research Institute, Commercial Road, Melbourne
|Principal Investigator:
|Jennifer Hoy, A/Prof
|Alfred Hospital, Melbourne, Vic 3004
More Information
Keywords provided by Jennifer Hoy, The Alfred:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
|Responsible Party:
|Jennifer Hoy, Professor Jennifer Hoy, The Alfred
|ClinicalTrials.gov Identifier:
|NCT00168233 History of Changes
|Other Study ID Numbers:
|Study First Received:
|September 9, 2005
|Last Updated:
|January 19, 2012
Keywords provided by Jennifer Hoy, The Alfred:
Treatment Naive
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
ClinicalTrials.gov processed this record on September 25, 2017


text:
YOUNG performers have a chance to take part in a huge production of one of the world's best-loved stage shows.
Youth Theatre Performerz are holding auditions for talented actors, singers and dancers to star in the biggest showing of Joseph and the Amazing Technicolour Dreamcoat in Clacton.
Director Melissa Wenn said the producers were looking for a new challenge and had come up with the idea of bringing the West End favourite to the resort.
"We want to involve as many young people from our community as possible and we have chosen a lower age group this time," she said.
"All they have to do is turn up on the day for a part as a dancer, in the choir or as one of the main characters."
Auditions will be held at the Princes Theatre, Clacton, on September 21, with dancers taught the routine from 10am to 11.30am, the choir learning a song from noon to 1pm, and main characters preparing lines to be heard from 1.30pm and 5pm.
Rehearsals for the big production will then begin in February.


text:
Classicism - A Brief History
Classical art is generally known to be influenced by the Ancient Greek and Roman aesthetic. Without doubt, classicism in art has long been the subject of much discussion by art enthusiasts in defining the themes and subtle nuances appearing in this esteemed art form. Classicism is also the antithesis of romanticism as it attempts to convey emotions or sentiments within a limited manner.
Fine Classical Art Prints
In more ways than one, classicism in art has breathed life into out approach towards understanding the depth and meaning of classical art. It has also been attributed to the onset of modernism and served as a basis for the contemporary art form that we see today. The high regard for classical art print has piqued the general public's interest in acquiring a poster or a canvas art that depicts classicism – it is a viable and effortless way for individuals to own a piece of classicism fine art poster.
Reviving Classicism through Poster Art
The fascination towards classicism in art has inevitably allowed these artworks to be reproduced in different forms such as art print, poster and canvas art. Undoubtedly, classical art poster or print can inject a sense of warmth and richness into any living space. And besides, who is to object that classicism in art can transcend all boundaries? ARTFLAKES is your answer to a multitude of fine art prints, posters and canvases ranging from the sublime to the dramatic fitting for art enthusiasts and aficionados.


text: Wrestlers from the TV show Hulk Hogan's Micro Championship Wrestling (MCW) recently tore down the boundary between video games and wrestling. The MCW wrestlers became characters in the video game AdventureQuest Worlds, and the game's armored creator found himself battling his lifelong arch-rival in a "Stink-Face Match" inside a real-life wrestling ring. (Albeit, it was a ring meant for little


text:
You all have sent in a lot of questions lately about coupons that won't scan at various stores, especially Dominick's and Walmart. Here's the deal: Coupons are transitioning to a new barcode called the GS1 databar. This can carry much more information than the older-style barcodes, including things like start date (which is why some of you found that when you bought the early edition of the 2/19 Tribune, the Tylenol Precise coupon didn't work at Jewel yesterday — it wasn't coded to turn on til 2/19!).
Older POS systems (cash registers) won't recognize the new-style GS1 barcodes; they just won't scan.
So, this is why you've seen stores transitioning to new-style registers. Jewel, for instance, is currently in process, which is why at some stores the same coupon will scan at the regular lanes but not self-checkouts. However, a lot of stores haven't yet done this yet, so just physically cannot scan the new barcodes.
Manufacturers are changing now
If you look at some of your manufacturer coupons, some have both barcodes — the older barcode on the left, and the new-style barcode on the right. Well, some manufacturers are choosing only to print the new barcodes on their coupons, and they no longer have the older barcode for stores to scan. Look at the Tylenol Precise coupon above — see how it only has one barcode, and it doesn't have the numbers under it like the older longer barcodes?
Stores were supposed to change over by June 2011. Well, that date came and went… The newer GS1 databar is intended to reduce coupon misredemption, and manufacturers are very anxious to see it rolled out. So, they're just going ahead and doing it, apparently on the assumption that stores will now have to get on the ball.
So what's the problem?
Some stores have coupon policies that prohibit them from taking coupons that won't scan at the registers. For instance:
- Dominick's — "15. Internet printed coupons must be capable of scanning at checkout." Well, what happens when you print a coupon off the Internet that only has the new GS1 barcode and go to a Dominick's that hasn't updated its registers? Yup, you guessed it, now your coupons are not scanning at Dominick's. This isn't your fault, and there is nothing illegitimate about the coupon itself — however, Dominick's that strictly adhere to their coupon policy won't take them. This will be an issue until they update their registers.
- Walmart — "Must have a scannable bar code." Well, at Walmarts that haven't updated their registers, the barcode isn't scannable.
Some stores will punch in the coupons manually. Others will just hand them back to you, especially if they are Internet printables.
So what can you do?
Not much — the coupons just will not scan until stores update their systems. You can complain both to your store and to the manufacturer about legitimate coupons that you are unable to use, but as things currently stand and as the policies are worded, that's what's going on.


text:
This week's issue of NI News shows NI products in some pretty extreme applications, like the Red Bull Stratos mission and the 2041 International Antarctic Expedition.
So, my question this month is, what would be your ideal extreme engineering adventure?
NI News/Content Specialist
04-03-2012 12:44 PM - edited 04-03-2012 12:45 PM
04-03-2012 10:40 PM - edited 04-03-2012 10:41 PM
Nato Sea Sparrow Missle System
I was weaned on NSSMS (now called Sea Chicken) and have found little since then that can match-up.
It had 27 modes of operation that would allow it to take battle damage to multiple parts of the system and still deliver the weapon. i will not try to list hem all but and extreme example would be;
Transmiter is system A down and reciever in system B is damaged AND the computer was destroyed.
Analog circuit would kick-in in using the transmitter from B to illuminate the target and A to track it while analog back-up circuitry solved the fire-control problem and kept the bird on target.
Well that worked a bit better than this one
http://www.youtube.com/watch?v=ey-pxV7qPZQ (language warning)
Hornless.Rhino wrote:
Well that worked a bit better than this one
http://www.youtube.com/watch?v=ey-pxV7qPZQ (language warning)
I never got directly invloved with topedos so I can not say more than it looks like they have a low pressure problem.
Re: Sea Chicken and over-engineered...
Durring qualtifications we had an oppertunity to be proven using drones where we had to take out ... something like 3 targets with up to five birds. For the purposes of evealuating hit/miss we did not fire normal birds but rather telemetry birds where the warheds were replacd with telemetry gear. At the time (circa 1980) the Sea Sparrow used peanut tubes so the technology available at the time ruled out recording the info on-board the missle so all of the perfromance info was radioed back to teh ship where banks of reel to reel tapes were running to record the flights and determing hit/miss.
The criteria for a hit was based on the weapons characteristics. In the case of Sea Sparrow, it was a large grenade (expanding ring) intended to inflict enough damage to an air frame. So getting the bird to within (I believe) 40 feet was a undisputed kill. Outside that radius required an expert to "read the tea leaves".
So the day of the trials we were all excited and looking forward to launching five birds.
Enough background info...
Bird #1
Direct hit! No war head required. Massive ball of fire (as was reported to me since I ws down in Combat Control operating the MK-58A Search radar)!
Bird #2
So close it was declared a hit before the next drone was launched.
Bird #3
Direct hit! Again, just a big projectile with a load of tubes and resistors did the job.
Bird # 4
Word came down quickly that we were done. We had already destroyed two perfectly good drones and they did not want to waste any more.
I used to tell people "We could track and kil a nat if you could get it up to 200 knots*!'
* 200 knots was the minimum velocity required to introduce the required dopler shift used by the Fire Control Radar.
...and now for something complete LabVIEWish...
I have to be careful since the following description describes a comercial product offered by one of the other contributors to this forum, who I assisted in the design and development. I have never read of any other LV application that even comes close to the capabilities that were included.
Develop an application capable of monitoring conditions 24 X 7 forever for an unspecified number of sensors.
1) sensor interface was distributed via serial with every collector battery backed-up and capable of storing reading if comm went down.
2) Sensor interfaces were controlled from FieldPoint nodes that would query sensors interfaces (if comm was available) and would transfer to main collection system when comm was available.
3) FP could buffer about a week of readings for all ofthe sensors in its network if Main app was down.
4) Handshaking between FP nodes and Main app were interlocked such that the data in the sensors interface was never deleted until the main app confiremed it was written to disk.
5) FP units handled all limits and alarms locallt in the event the main app was down.
6) All functions of the main app were tracked and logged such that a machine failure at anytime in the process could be recovered without data loss.
7) Backup transaction logs allowed fail-over to the secondary system if attempts to recover the primary failed due to disk failure.
I counted it as an honor to be allowed to contribute to that system. I had a FP node running for about 9 months on my desk. I used to get a kick out of power fails in the office when I would look up and still see the lights flashing.
Aside from the microcode running in the sensor interfaces, it was (and is) 100 % G.
...and Ben's contributions to that system live on in the second generation, directly and through tutelage. Largest initial installation (33 cFP nodes, 400+ sensors) being installed next month. Replaces our first, and largest, DOS installation, startup ~1993 or so. Thanks Ben.


text:
Avg.Rate: US$ 50.00 - 100.00
Rating: 3 stars
Featuring a spa centre, Nican Resort offers accommodation in Seguku Katale, 10 km south of the centre of Kampala. The hotel has an outdoor pool and guests can enjoy a meal at the restaurant. Free WiFi is available. Every room at this hotel is air conditioned and is fitted with a flat-screen TV. Some units feature a seating area where you can relax. Extras include bathrobes, slippers and free toiletries. The restaurant serves local and international cuisine and cocktails and drinks can be enjoyed at the bar. Evening entertainment is offered on selected days. Nican Resort has a garden, a children's playground, conference and meeting facilities. For relaxation, there is also a fitness centre and a sauna. Massages are offered. Activities on site or in the surrounding area include cycling, golfing and fishing. The Nakigalala Tea Estate is 4 km away. もっと見る


text:
find a dealer
find your local bike shop
Search the National Bicycle Dealers Association database of dealers across the country. This database is maintained by the good folks at NBDA.
We can't guarantee that the dealer you find here will carry Planet Bike products- so call ahead. If they don't carry them, please request that they do.


text:
Sapphire and Diamond CZ Silver Ring Set
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With gems that seem to hold the deep depths of an ocean at your fingertips, this Sapphire and Diamond CZ Silver Ring Set is a shimmering treasure. The deep blue cubic zirconia stone that rests in the band can drink in any gaze as it sits primly atop the band. The center white diamond cubic zirconias that rest in the center of the ring create a sparkling curtain of lights that create a stunning contrast with the sapphire. The ring's center stone measures 7 X 7mm and the rings set weighs an easy 10.1 grams and has a total carat weight of 3.5 carats to make this sapphire and diamond CZ silver ring set an easy choice.
Details: • Princess Cut Diamond Cubic Zirconia • Rectable Sapphire CZ's on Bands • Two Seperate Stackable Rings
- Metal
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Comments about Sapphire and Diamond CZ Silver Ring Set:
I bought this set twice ! ( once bc I gained weight it runs a bit small) the only issue is the band with the engagement is sort of thick & tight I'd recommend sizing up if you're a half size. I lost my ring so getting a realistic 2 carat wasn't as easy as I thought - this set is made like a high quality set - the setting , etc looks like white gold after u wear it a while to get the shiny off- the Cz looks real & several times I've been told how gorgeous my ring is! I think there is a real set like this I saw in a bridal magazine - if you're looking for a set to wear daily get this you won't be disappointed I wore the diamond ring only & though thick it's quite comfy!


text:
Fluconazole Prophylaxis of Thrush in AIDS
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Acquired Immunodeficiency Syndrome Candidiasis Oral Candidiasis
|Drug: fluconazole
|Phase 4
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|Fluconazole Prophylaxis of Thrush in AIDS
|Estimated Enrollment:
|Study Start Date:
|July 1996
|Estimated Study Completion Date:
|November 2001
Oropharyngeal candidiasis (OPC) occurs in up to 93% of persons with human immunodeficiency virus (HIV) infection at some time during the course of their illness. OPC usually responds well to initial antifungal therapy, but with increasing immunodeficiency it usually recurs and can become resistant to clinical and microbiologic cure. Therapy usually begins with topical agents, followed by systemic therapy with azole antifungals when those fail. Amphotericin B is also used, but is less well tolerated and usually only effective in parenteral form. Because of its bioavailability and efficacy, fluconazole has become the most commonly used agent in treating OPC. Recurrences have often led to frequent re-treatment or prophylactic therapy with fluconazole. Daily prophylaxis with fluconazole (200 mg) has been shown to decrease the incidence of OPC. With the widespread and prolonged use of fluconazole reports of clinical failures and yeasts with decreased susceptibilities have appeared. This resistance appears to be associated with advanced immunosuppression and azole exposure. The most effective regimen to decrease relapse and morbidity from OPC which minimizes development of resistance has not been established. Could less frequent and/or lower dose prophylaxis with fluconazole decrease the incidence of recurrences while slowing the development of drug resistance?
We plan to perform a two phase study of low-dose fluconazole prophylaxis in HIV infected patients with a history of OPC. Patients with advanced immunosuppression (CD4 less than or equal to 150 cell/mm3) who have not received prior fluconazole prophylaxis will be included. Phase 1 of the study will be a placebo-controlled trial of fluconazole at a dose of 200 mg three times weekly. Phase 1 will examine whether this low-dose prophylaxis can delay recurrence of OPC. Phase 2 of the study will be an open-label prophylaxis with fluconazole at first 200mg thrice weekly, then 200mg daily as patients develop recurrent OPC. In this phase the primary question to be answered will be whether subjects starting in the placebo arm of Phase 1 will progress more or less rapidly to clinical fluconazole failure compared to those starting in the fluconazole arm. We will learn more about the natural history of fluconazole resistance, including how gradually the change occurs, how much fluconazole the patient has received at the time resistance develops and whether the resistance occurs in the patient's own isolate or from acquisition of a new isolate. Other evaluations will include compliance, cost, and host and organism-associated factors. If thrice weekly fluconazole prophylaxis can increase the time to development of resistance and decrease episodes of OPC in this group of severely immunocompromised individuals, it would increase the effective use (to include cost-effective use) of fluconazole in the treatment of OPC.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
HIV infection previously documented by ELISA test kit and confirmed by either Western Blot, HIV antigen, HIV culture, or a second antibody test other than ELISA.
Age 18 years or older.
CD4 count of less than or equal to 150 cells/mm(3).
At least one prior episode of health care provider diagnosed oropharyngeal candidiasis in the 6 months preceding enrollment.
No allergy or intolerance to azoles.
Less than 3 episodes of oropharyngeal candidiasis within the last 3 months.
No history of esophageal candidiasis.
No presence of systemic fungal infection requiring continuous antifungal therapy.
No use of continuous azole treatment (i.e. daily, weekly, every other day, twice weekly fluconazole, itraconazole, ketoconazole or coltrimazole) for the prevention of fungal infections greater than or equal to 1 month within the past 6 months.
No severe liver disease (ALT or AST greater than 5 times the upper limit of normal).
No history of poorly responsive mucosal infection (i.e., requiring more than 200 mg of fluconazole daily or more than 14 days of therapy).
Females may not be pregnant or lactating. Must have a negative pregnancy test within 2 weeks of enrollment.
No one unlikely to survive more than 6 months.
Must have ability to tolerate oral medications.
No presence of active mucosal infection or symptoms of OPC/EC at time of initial assessment. (Note: Can enroll 2 weeks after resolution of the active episode).
No patients currently being treated with azole for recent mucosal infection. (Note: These patients can enroll 2 weeks after the completion of azole therapy.)
No presence of severe renal insufficiency as indicated by a serum creatinine greater than or equal to 3.0.
Women must be taking appropriate birth control measures.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00001542
|United States, Maryland
|National Institute of Allergy and Infectious Diseases (NIAID)
|Bethesda, Maryland, United States, 20892
|ClinicalTrials.gov Identifier:
|NCT00001542 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 3, 1999
|Last Updated:
|March 3, 2008
Keywords provided by National Institutes of Health Clinical Center (CC):
Candida Albicans
Additional relevant MeSH terms:
Immunologic Deficiency Syndromes
Acquired Immunodeficiency Syndrome
HIV Infections
Candidiasis, Oral
Immune System Diseases
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Slow Virus Diseases
Mouth Diseases
Stomatognathic Diseases
Antifungal Agents
Anti-Infective Agents
14-alpha Demethylase Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Steroid Synthesis Inhibitors
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Cytochrome P-450 CYP2C9 Inhibitors
Cytochrome P-450 CYP2C19 Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


text:
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text:
|Keren Kayemet L'Israel Committee, Rakov,
Tarbut School, January 17, 1938
The Rakov library was known as one of the most important libraries in the whole region, but for some reason, the actual management of this important cultural institution was in the hands of people who referred to themselves as Yiddishists [supporters of the Yiddish language], and the part of the library which was devoted to Hebrew books was small. We decided, therefore, to take steps to change that. In one of the joint meetings of the Executive Committees of HaShomer HaTsayir and of HaHalutz HaTsayir it was decided to 'penetrate' the Board of the library, and force it to change. We started the struggle, quietly and persistently, and in the next general election to the Board we succeeded in electing some of our comrades: Shmuel Rubinstein-Avni, Hayim Tejf, Shimon Shapira, and myself. And a new era began in the library. We purchased Hebrew books, and the number of readers of Hebrew literature increased. Slowly but surely, we transformed the general character of the library, and it started to act in concert with the Rakov Zionist Movement.
|Malka and Avraham Grinholtz
Zionistic Ha'Histradut Chairman, Rakov
We succeeded in having Meir Levin zl elected to the local Town Council, and he served as the Deputy Mayor.
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Updated 23 Mar 2005 by LA


text:
Xavier losing to Ohio State in the 2007 NCAA Tournament is my most painful loss. So many little things had to go wrong in the last few moments of the game--and they all did.
Xavier losing to Ohio State in the 2007 NCAA Tournament is my most painful loss. So many little things had to go wrong in the last few moments of the game--and they all did.
The 1999 playoff is probably number one for me for a couple of reasons,
1) The Reds didn't "win" anything that year. As much as the Bengals playoff losses stung, and the Reds 3 and out hurt this year, those teams still won their respective divisions. Super Bowl XXIII stung but that team won the AFC.
2) The Reds play over the next 10 years made that sting in 1999 worse. Since 1999 wasn't really a building block, I just can't look at it as anything other than an opportunity missed.
3) The sheer domination, much like what we saw in game 1 against Halladay, at a certain point you knew the loss was inevitable. They'd already scored and you weren't going to.
Hopefully, the New Red Machine will take away the sting of this playoff loss.
1. OSU vs. Florida - Just a totally different team than the one that played the regular season. Really difficult to watch.
2. 1999 One game playoff
3. Jordan pushing Russell and then hitting "the shot" to beat the Jazz in the 97 Finals. This would be #1 except it was only Game 6 so the Jazz would have still needed to win one more.
4. The 2005 OSU losses to Texas and PSU were tough mostly because that was a super talented team that lost two very winnable and very frustrating games that they should have won.
Miami (FL) vs Ohio State.
That game solidified Larry Coker as the coach most Miami fans knew he was: Awful. You let that collection of talent lose to Ohio State? Simply terrible. And Randy Shannon too. Your defenses are soft. . . just like they are now. ANy defense looks great when everyone is drafted.
Florida vs. Nebraska in the 1995 Fiesta Bowl, for the National Championship. Everyone was picking us to win and it was an absolute joke. I think Tommie Frazier just scored again.
Pain was eased a little bit when we rebounded the very next season and beat hated rival FSU for the NC in the Sugar Bowl.
I heard your record..it's alright.
Off the top of my head, RR beat VT in '02 and '03, beat UGA in '05, Ga Tech. in '06, and his team beat Oklahoma in '07 right after he left. They had Miami beat on this run in '03 that won the ESPY (bad video quality):
YouTube - WVU Quincy Wilson
Then this happened. Sickening :
YouTube - Kellen Winslow Jr. 4th Down Catch vs. WVU
He got constantly pounded by Maryland until Rasheed Marshall's senior year, and until White got there.
Regarding the defense, WVU was 7th in the nation that year in defensive PPG, and 4th in YPG behind USC, LSU, and OSU. In 2006, the team was all offense and no defense. White and Slaton just went absolutely nuts, and finished 4th and 6th in the Heisman voting. However, the defense cost them at Louisville (lost 44-34 on Thursday night, I was there, it's probably in my top 10 painful losses).
WVU/UK elite eight game
1999 play in loss vs the Mets
Bengals/Jets last year in the playoffs
Just a few that stick out right now.
The OSU losses to Florida and LSU really sucked (the Florida one especially since our new youth director is from there and occasionally rubs that in) and the Bengals playoff game in 2005 when Carson got injured really sucked (I was out of town and my mom was updating me on the game...I was devastated every time she texted me), but the most painful sports loss in my lifetime was when Michelle Kwan came in second to Tara Lipinski in the 1998 Olympic Games. Michelle had to skate first and skated extremely well but then the twerp came out later on and simply perked her way to the gold medal. I'm still convinced to this day that had their skating order been reversed that MK would have come out with the gold medal. I know she still won the silver and all but that heartbreak made her coming third in the 2002 Olympics that much more painful for me.
"I tried to play golf, but I found out I wasn't very good." -Joey Votto on his offseason hobby search
An MLB.com reporter asked what one thing Votto couldnt do. I cant skate or play hockey, Votto said. Well, I can skate ... but I cant stop.
WVU fans argued once the seeds came out that they should have been a number one seed over Duke. I didn't think so, but I did think they deserved it over Syracuse. The Orange faltered down the stretch and WVU won the Big East tournament. However, nobody wanted to deny two number one seeds to the Big East. It simply made the conference look better.
The same fans crowed over how they beat pretty much the same Duke team two years ago when they met up with them in the Final Four. Nevermind the fact that this team probably had revenge on its mind and completely dismantled WVU and embarrassed them in the biggest game in program history. And of course, the moment the heart was ripped out of the entire state when DaSean went down.
So to basically claim that you should have gotten a no 1 seed over that team (I agree WVU should have been a no 1 seed, just over Syracuse) and then get throttled by that team was pretty amazing.
Sad thing though about that game is trying to decide who to pull for if you are a UK fan. It's like pulling for the murderers or the rapists. One is hated for obvious reasons (Laettner), and the other knocked Kentucky off in the previous round.
My toughest loss was watching my then junior son Jason's Wayne High School Pioneers lose the WV State Championship AA football game last December in Wheeling to Bluefield. Since Wayne is also my alma mater I would have rooted for them anyway (they did win the state title in 2006 before Jason was in high school), but I really, really wanted my son to get a championship ring.
The 1972 World Series was a huge disappointment. I still think the Reds were the better team. The 1973 NLCS stunk too.
Both of the Bengals Super Bowl losses were tough to take.
"Hey...Dad. Wanna Have A Catch?" Kevin Costner in "Field Of Dreams."
Kenyon Martin breaking his leg..
Then losing to WVU in the BEast Tournament last year on the last second bank by Butler..
Unbelievable losses
Cincinnati Bearcats back to back Big East Football Champs
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text:
Take a look at our Xtra section which brings you a wide range of feature articles every week.
This week's features include:
BOOKS: Former daytime TV presenter Judy Finnigan is relishing her new career as a novelist and life away from the cameras. She talks about the late Caron Keating, who inspired her debut novel Eloise, her relationship with husband Richard Madeley and why she has no desire to return to tv.
CELEBRITY INTERVIEW: The final film in The Twilight Saga, Breaking Dawn: Part 2, hits cinemas on Friday, November 16. Robert Pattinson, Taylor Lautner and Kristen Stewart reveal their favourite memories, weirdest fan moments and how they think they'll cope without the adulation of 'Twihards'.
GARDENING: Tips on some of the best presents on offer for the green-fingered this Christmas - plus, find out what else needs doing in the garden this week.
HEALTH: As new research suggests that around 70% of the 10 million Britons who suffer from chronic pain don't have ongoing help to ease it, pain management experts explain what treatment options are out there, and why the UK doesn't need to be a nation that 'just puts up with it'.


text:
Children's Day is celebrated globally, different countries have different dates to honor children on a special day. Guatemala celebrates Children's Day on October 1st, usually family members make the little persons in their lives feel celebrated by giving them a special treat, going on a special outing or making them a special meal, and at school they have a fun filled day with activities and goodies.
I'm sad that this year Kristen won't be able to celebrate Children's Day at school because she got sick, but we will try to make her feel special with homemade treats… and we'll probably have a Disney Princess movie marathon.
Here are some ideas (a lot of them are quick!) you can try at home to celebrate your child:
Goldfish Pizzas
at Pepperidge Farm
Nerds Cupcakes
by Mom's Crazy Cooking
Mini Corn Dog Muffins
by Happy Good Time
Magic Potion
by Mrs. Happy Homemaker
(it changes color as the ice melts!)
Chocolate Covered Bananas
by Martha Stewart
Cupcake Fondue
by Oh Sweet Babies
© 2012 – 2016, The Foodies' Kitchen. All rights reserved | The Foodies' Kitchen.


text:
Hi everyone.
I've become really frustrated lately with my lack of distance. I'm not a strong guy, but I feel like I should be able to throw at least 400'. My current average distance is probably only around 270', and when I get a decent release, I get to ~320'. My biggest problem in trying to add power is nose up stalls. I've started doing the right pec drill, and today I took some videos trying to incorporate what I've learned there with what I'm already doing. I slowed down my approach as well. I threw all putters, and slowed down the video for better analysis. These all probably traveled between 180 and 200 feet.
Thank you so much for any help you can give me.


text:
Ashton Lee
5 Stars
I would recommend this item to a friend.
Versatile Positioning
February 9, 2010
This fireplace is great! Assembly using a power screwdriver took several hours, but the instructions were pretty easy to follow. We put it in our sunroom, and it looks very nice and adds a warm feel to the room. It can placed either in a corner or against any flat wall. I didn't really measure carefully, so it was a little smaller than I expected, but it works fine anyway. We have our 39" television sitting on top of it, but it is large enough to hold a 42" or maybe even a 46" set.


text:
With a new album and a headline gig in Dallas, Kelli O'Hara isn't always a theater queen
RICH LOPEZ | Staff Writer
A day after her second album is released, Kelli O'Hara isn't dealing with a tour publicist or her booking agent. Instead, she's driving while her son is in the back seat. Not the image you immediately imagine for a three-time Tony nominee and Broadway star, yet it's what you expect from the Oklahoma native.
"I'm sorry he keeps crying," she says. "I'm trying to get him to sleep."
As accomplished as O'Hara is, she doesn't put on any pretensions of the star that she is. She only made her Broadway name with Jekyll & Hyde, followed up by Sweet Smell of Success: The Musical and The Light in the Piazza. All which helped put her on the map as a strong leading stage actress. She scored big with her role as Nellie in South Pacific, earning her third Tony nom and second Drama Desk Award nomination.
Lately, though, she's all about the singing.
"I really wanted a record that represented the solo concert I had been doing," she says. "Always features theater music, but as soon as I made this one, I wanted to make a country album. I'm a little schizo that way."
Practically just hours out of her second CD release, O'Hara is a mixed bag of emotions which lends credence to her admission.
"There's always more work to do, but I feel relief, excitement — all of the above," she says. "I'm excited to have this because I've been wanting a new album for a while. Now begins the fun…or work."
O'Hara comes to town Saturday to headline the Dallas Theater Center's fundraiser Centerstage. The Oklahoma native is familiar with these parts. She would visit Dallas on a regular basis for family reunions. As it turns out, that'll be the case somewhat on Saturday.
"It's been a long time since I've worked outside New York City," she says. "I'm excited. And my parents will be there."
But she is sensing a pattern in her special event gigs. When she discovered that drag queen Lady Bunny is DJing the night, she laughs.
"You know, I get paired up like that a lot," she says. "I was with the Seattle Gay Men's Chorus and then this drag queen Liza. I don't know what I represent, but I guess it's where I belong!"
Centerstage. Dallas Theater Center, 2401 Flora St. June 4 at 6:30 p.m. DallasTheaterCenter.org.


text:
SN 1.34 Nasanti: They Are Not
Translated by Bhikkhu Nananada
http://www.accesstoinsight.org/lib/auth ... #passage-3
The Exalted One was once staying near Saavatthi, at the Jeta Grove in Anaathapi.n.dika's Park. And a great number of the Satullapa company of deities, when the night was far spent, came into the presence of the Exalted One and so standing, one of the deities uttered this verse before the Exalted One:
No permanent pleasures of sense are there among human-beings
Here are charming things enmeshed in which a man dallies
And thus from realms of death doth never come to that
Wherefrom there is no coming back again.[11]
Desire-born misery, desire-born pain
Desire disciplined is misery quelled.
[The Buddha:]
When misery is quelled, pain too is quelled.
They are not the sense-pleasures — those beautiful things in the world
Lustful intention is man's sense-pleasure
They endure as before those beautiful things in the world
But the will thereto, 'tis, that the wise discipline.
Let one put wrath away and conceit abandon
And get well beyond the fetters all[12]
That one, by name-and-form untrammelled[13]
And possessionless[14] — no pains befall.
He cast off reckoning, no conceit assumed
Craving he cut off in this name-and-form
That bond-free one — from blemish and longing free
Him no gods nor men, in their search could ken
Searching here and beyond — in heavens and in all abodes.[15]
If him they find not thus released [thus said the reverend Mogharaajaa],
Gods and men, here or beyond
Him best of men that brings weal for men[16]
They that revere him — are they worthy of praise?
Yea, they become praiseworthy also, [O monk, Mogharaajaa; said the Exalted One],
They that revere him thus released
Yea, if knowing the Norm they give up all doubt
They too become bond-liberated, O monk!
[11] Nibbaana is called 'apunaagamana' ('from which there is no coming back again') as it is an irreversible attainment. This transcendence of the world is often compared to a 'crossing-over to the further shore.' 'The saint having crossed over and gone beyond, stands on dry ground' (ti.n.no paara.mgato thale ti.t.thati braahma.no' — ) 'Once he has crossed over, the such-like one comes not back' ('paara.mgato na paceti taadii — ). 'To the further shore they go not twice' ('na paara.m diguna.m yanti — ). The sense of irreversibility is also conveyed by the term, 'akuppaa-cetovimutti' ('unshakable deliverance of the mind') signifying arahantship.
[12] The ten fetters that are to be abandoned in the course of one's progress towards Arahantship: They are: i. personality-view ii. uncertainty iii. adherence to rites and rituals v. greed for sense-desires v. resentment vi. attachment to Realms of Form vii. attachment to Formless Realms viii. conceit ix. agitation x. ignorance.
[13] 'Name-and-Form' (naamaruupa): Feeling, perception, conation, contact, attention — these, friends, are called 'name.' The four great elements and form dependent on them — these, friends, are called 'form'" — As the object and support of consciousness, name-and-form is sometimes conceived as a net in which consciousness is enmeshed. Thoughts and intentions have, as their object, some aspect or other of this name-and-form (). So long as the agglutinative tendency of craving is not eliminated, consciousness is unable to transcend name-and-form, and is perpetually caught in a vicious circle. The Buddha and the arahants succeeded in escaping the net by giving up all attachment. Their consciousness, now illumined by wisdom, penetrated it and soared untrammeled and unrestricted, out into an infinitude (), by way of the three deliverances — the 'signless' (animitta), the 'undirected' (appa.nihita) and the 'void' (su~n~nata).
[14] aki~ncana: ('possessing-nothing') An epithet of the arahant, connoting the absence of lust, hatred and delusion. "Lust, friend, is a something (ki~ncano). Hatred is a something, delusion is a something. In a monk whose influxes are extinct, they are abandoned, cut-off at the root, rendered groundless, made extinct and are incapable of arising again." —
[15] When the subtle conceit 'I am' (asmimaana) is eradicated and the attachment to name-and-form is given up, consciousness loses its support and becomes unestablished (appati.t.thita vi~n~naa.na — S. I. 122). It does not stand in any realm of existence (vi~n~naa.na.m bhave nati.t.the' — ).
[16] Here, the reference is to the Buddha.


text:
NO ONE involved in the debacle known as AB 76 has brought any glory on themselves. That's the legislation, passed by both houses of California's Legislature, that would make local government's compliance with California's Public Records Act voluntary. If passed, the Golden State's pioneering transparency in government law becomes useless.
Assemblyman Marc Levine, D-San Rafael, along with most Democrats, voted "yes." State Sen. Noreen Evans, D-Santa Rosa, was no profile in courage. She ducked the vote despite being present. Even Gov. Jerry Brown was prepared to sign AB 76 before the firestorm ignited by every newspaper and media outlet in the state erupted.
Shining the spotlight on the bill changed everything. Suddenly everyone in Sacramento is embracing a proposed constitutional amendment that embeds the public document disclosure law in California's constitution. That'll make the reform permanent.
The objectionable section of AB 76 was introduced due to current requirements that the state treasury reimburse localities for their alleged $20 million annual cost of compliance. These reimbursement claims are nonsense.
What many cities, counties and special districts do is lay off some of their normal day-to-day costs by claiming that they were incurred answering public document requests. It's a cost-shifting rip-off. Actual expenses are negligible.
If it wasn't for the Public Records Act, shenanigans surrounding former Ross Valley Sanitary District manager Brett Richards would never have been exposed by the IJ. Nor would the financial irregularities at the Novato Fire District been uncovered without the current law.
LAST MONTH Napa County Supervisor Mark Luce traveled to San Rafael to lecture Marinites on the brilliance of ABAG's Plan Bay Area. He was joined on the platform by Marin Supervisor Steve Kinsey. Luce is a veteran regional politician and president of the Association of Bay Area Governments (ABAG).
The Napa Register reports that Luce took a very different and far less growth-promoting stand when it came to Plan Bay Area's specifics for his Napa constituents. ABAG designated a section of Napa as a PDA (priority development area) complete with high-density housing mandates. Luce, who historically takes green slow-growth positions, objected, saying, "I personally don't like a PDA in the city of Napa." Ironically, Luce ultimately backed down under local pro-growth pressure.
While hypocritical, Supervisor Luce should get credit for realizing that ABAG's one-size-fits-all planning isn't best for his Napa constituents. Ideally he'll come to understand that surrounding jurisdictions are in a similar fix. It's time for Luce, as well as his ally Kinsey, to show a little leadership.
They can do so by calling for the modification of Plan Bay Area so that local zoning isn't subject to coercion from ABAG forcing high-density housing where inappropriate with existing communities.
WE ATTENDED the sold-out Opening Day ballgame between the San Rafael Pacifics and the Vallejo Admirals. Besides being good family-friendly fun it's clear that concerns about bringing professional baseball to venerable Albert Park were overblown.
Gerstle Park neighborhood residents' worries about traffic, parking and a bad element frequenting the games were legitimate. The good news is that the mitigation measures undertaken by the city of San Rafael work. The crowds are friendly, traffic was no big deal and parking adequate.
It was a fine small-town evening scene. Kids were everywhere, older folks intently watching the game, local pols glad-handing the crowd, young couples were out on a cheap date with team mascot Sir Francis the Drake engaging in his usual antics. My only suggestion is that the food concession needs to move a notch up in variety and with shorter waiting times.


text:
Well, we're big rock singers, we got golden fingers and we're loved everywhere we go. We sing about beauty and we sing about truth, at $10,000 a show. We take all kinds of pills to give us all kind of thrills, but the thrill we've never known is the thrill that'll getcha when you get your picture on the cover of the Rolling Stone.
Dr. Hook & the
Medicine Show, 1972
The biggest question Bostonians have about the bombing in their city on Patriot Day is the one they've had since right after suspected terrorist Dzhokhar Tsarnaev was arrested in April: What turns a kid who was not just loved but beloved -- the favorite of multiple teachers and coaches, and of many classmates -- into someone who could look his victims in the eye before blowing them up, then head off to the gym?
Janet Reitman's Rolling Stone piece about Jahar, as the younger Tsarnaev brother was known to his American friends, is an earnest attempt to answer that question. Some critics insist that it's mostly the glam photo on the cover that offends them; it does look like a PR shot for a member of a boy band.
But that Reitman has been getting death threats and around-the-clock calls on her cellphone from strangers who say they hope she dies in a terrorist attack suggests that the push back is about a lot more than a soft-focus selfie. Is terrorizing her standing up against terrorism, or becoming what you hate?
Saying that Boston is protective of its own is like saying that Washington summers are on the warm side; Bostonians want the feelings of the bombing victims put first, second and third, and who can blame them? One of the women who lost a leg in the blasts told me she didn't want to talk about the Rolling Stone piece, and it's not hard to understand why. In an earlier interview, she said she and others working so hard to recover are husbanding all their energies for healing and will not be giving anything more to the bombers than they have already taken.
MSNBC host Lawrence O'Donnell, who is from Boston, castigated Reitman's work at some length on his cable show, saying that her piece "spends most of its time in romantic reminiscence of what a great kid Jahar was, as described by many of his friends." He added, "Now, I talked to many of those kids myself on the streets of Cambridge, and I found them -- as the article does -- completely mystified about how their nice guy friend could possibly have been involved with the bombing. I, therefore, found them ultimately rather uninteresting people to talk to once that point was made."
Previous Rolling Stone covers featured Charles Manson and O.J. Simpson, yet the fact that most covers go to music stars made the decision to put Tsarnaev there controversial. As understandable and predictable as the pushback is, however, I'm still glad Rolling Stone has the piece -- and continued work on a puzzle we'll spend years trying to fit together.
Jeff Seglin, who writes a weekly ethics column called the Right Thing and is a public policy lecturer at Harvard's Kennedy School, says the negative reaction is a little like that of the Polish peasant in Isaac Bashevis Singer's "Enemies, a Love Story," who after coming through the Holocaust is shocked that there are books on the subject of Hitler: "They write books about such swine?"
Seglin thinks that the Rolling Stone cover photo is journalistically defensible -- and, in fact, that it is perfectly in keeping with the article's point that this was an ordinary kid gone terribly wrong.
At the time of the bombing, I was living in Cambridge, Mass., where my son was enrolled in the high school that Tsarnaev and his older brother, Tamerlan, attended, and I know how much pain was inflicted on a city I came to care about in my few months there.
But if publishing the photo was so outrageous, why was it OK for critics to share it all over social media? And isn't the corporate censorship by the stores that have elected not to carry this issue of the Rolling Stone in a sense scoring one for the terrorists by undermining free speech? They shouldn't sell Boston so short. Because, ultimately, as Boston Globe columnist Yvonne Abraham wrote, her city is way too tough to be knocked around by a picture on a magazine.
-- Melinda Henneberger is a Post political writer and She the People anchor who spent the past semester as a fellow at the Harvard Kennedy School's Shorenstein Center. Follow her on Twitter at MelindaDC.


text:
A Keighley student is writing a regular blog to raise awareness of arthritis among young people.
Collette McColgan relates her own experiences growing up with the condition on the arthritisactually.com website. She also writes a weekly blog for the national arthursplace.co.uk website, which offers support for children and teenagers with arthritis.
Collette, 23, is currently taking a masters degree in print journalism in Sheffield, and recently spent six months working for the National Union of Journalists.
Collette, whose mother, Majella, is the parental involvement worker at Parkside School in Cullingworth, was diagnosed with arthritis when she was just three years old.
She was inspired to start a blog after a young woman with rheumatoid arthritis – Cat Bull – carried the Olympic torch through Keighley while training to become a doctor. Cat writes the that girlwitharthritis.blogspot.co.uk blog.
Collette said: "My mum contacted Cat to go into Parkside School to do a talk.
"I started Arthritis Actually for myself. Not a lot of people know young people get arthritis – the more people who know about it the better.
"My blog has been re-tweeted by Arthritis Research, and the lady that runs arthursplace sent me a message asking me to write for them. I've written a few feature pieces for arthursplace and I do a weekly blog for them."
Collette said she tried to strike a "chirpy" note with her own articles.
She explained: "Hopefully, the blog is refreshing. It can be a bad situation, but I don't want to be seen as moaning about it. Because I got diagnosed at three, I never really had to deal with it. Some people are diagnosed as teenagers and everything changes for them.
"I've had periods when I don't need medicine, then there can be a massive flame-up and I'm back on it."


text:
Maddon sees AL East as 'wide open' this year
DUNEDIN, Fla. -- Rays manager Joe Maddon didn't hesitate to offer his comments when asked to handicap the American League East for the coming season.
The Rays manager began by noting: "It's wide open."
"Everybody's denigrating the Yankees for their age over experience," Maddon said. "Then you talk about the Red Sox and what happened last year. I expect them both to be very good this year."
Maddon then looked over at the opposing dugout in Dunedin and spoke about Toronto after its massive offseason overhaul.
"What the Blue Jays have done is very exciting for Toronto," Maddon said. "Part of it for them is how quickly they can get it together as a group. And if they do, they could be very dangerous. Baltimore showed what they could do last year. Baltimore started playing on another mental level last year. That's why they got so tough. And I think we're as good as we've ever been. So I think things can be very interesting."
When a reporter commented that the Orioles showed everyone that anything is possible with what they accomplished in 2012, Maddon smiled and responded: "I think we showed that in 2008."
"That's been rather contagious the last several years," Maddon said. "Baltimore, I really appreciate what they do and how they do it. They come to play. [Buck Showalter has] done a great job there. It's a different mindset among their players. They don't quit. ... They just don't quit and I expect the same thing."
Maddon agreed that picking a winner in the division would be difficult.
"Injuries will play a role in it at some point," Maddon said. "But I think it's going to be, who knows, but I think we'll all be good."


text:
Pen-Pal Listings : TalesFromTheCells.Com
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text:
[p. 94]
The beginning of the Russian defeats (The beginning of the Russian defeats)
A Committee for the Homeless was soon set up to provide them with a roof over their heads, as well as with food and clothes. The committee had several sections and one of them was responsible for cultural matters. Its activists led by Sonya Fel, Yakov Kirzhner, Bendet Nisht, Pinkhas and Menase Garber, and others devoted themselves to teach and educate the innocent homeless children so that they would not, God forbid, remain backward in their spiritual development.
With the help of some teachers, such as Leah Nisht, Breyne and Esther Terkl and others who, although still almost children themselves, were unselfish idealists, the cultural committee succeeded in establishing a three-grade Hebrew elementary school for both homeless and poor children of the town. The little voices of the pupils soon rose from the classes and delighted the teachers and the founders of the school amidst their hard work.
D. Selkof: At the end of the summer of 1915 (At the end of the summer of 1915)
Around Tisha be-Av of 1915 during the First World War, the entire Jewish population lived in deadly fear of each new day. One morning the rumor spread that the Jews of Krinki would soon have to leave the town because of the great Russian defeats on the whole battle front and the advance of the German army. The entire region between Grodno and Bialystok was classified as a strategic zone since the Germans concentrated immense forces in the region of the two big fortresses in Grodno and Osowietz. The Germans besieged the Osowietz fortress for six months and the shelling could be heard in our town. It was reported that the Jews of Grodno, just as those of the nearby shtetls, were expelled into the heart of Russia. We feared and expected that it would soon be our turn and we would have to abandon our homes and trades. It was especially frightful to think that the Gentiles would appropriate all our properties after we left the town.
And we would talk among ourselves about the imminent distribution of our property like this: Look, there is Tzapan, the limping shoemaker from Sokolker street, standing on the marketplace with a band of Gentile lads around him. He is showing his friends with his thick stick which shop and its stock he will inherit when the Jews flee the town. Or take Yurhilo, the wet tannery worker, who walks around barefoot with his feet black and bruised and begs some kopecks from the Jews every Friday. He wants nothing less then Itshe Mostovlionske's brick house!
[p. 95]
The entire local police force ran away from Krinki one night and abandoned the shtetl. An officer with a group of barefooted soldiers took over the power, declared a state of war and proclaimed himself interim commander. We all feared that he might order us to leave the town.
One evening a whole crowd of Gentiles descended upon us with spades and axes on their shoulders. At first we thought that they were rioters ready for action but it soon turned out that they were sent to Krinki to dig trenches against the attacks of the enemy. We learned from the Gentiles that they came from Sopotzkin where they had also dug such trenches, but German planes flew over them and started dropping bombs and in the end they were forced to retreat. Thus we learned again that the Germans were close to Grodno. Meanwhile Virion's grove was cut down to make room for the trenches. The Jewish youth was not hired for this work even though many of them would have been eager to earn two rubles a day. The Jews were excluded from the war operations because of dreadful false accusations against our brethren, the sons of Israel, which said that we were on the side of the Germans and even supported them in many ways. Naturally, after such rumors the Jews could not expect anything good either from the Gentile population or the Russian soldiers.
The pits were finished, ready to be used in battle but a miracle happened and the Russians had no time to use them. The Germans arrived and the Russian army was forced to retreat. As they were retreating they burned down everything on their way. Flames were blazing in all the villages around Krinki. The Russian soldiers spent a whole night trying hard to burn the great water mill which was not far from the town. But as if to spite them, the wooden wheel, which was thoroughly wet, did not catch fire and the mill remained intact. Later when the Germans came into Krinki the mill became very useful: all the poor Jews could go and grind a pood (a Russian weight of about 36 pounds) of rye there to bake bread for their families.
[p. 98]
The German occupation (From Fall 1915 to Spring 1919) (The German occupation (Fall 1915 - Spring 1919))
Dov Rabin: Under the pressure of the occupier (Under the pressure of the occupier)
Under pressure and in distress (Under oppression and great needs)
When the Germans entered Krinki, the Jews in the surrounding communities sighed with relief. At first the Jews felt liberated from the Russian regime which had discriminated against them and persecuted them, and threatened their physical survival for many generations.
But a harsh occupational regime established itself very soon. There began a series of forced labor on the highways. Food and various merchandise such as leather, metals and chemical products were requisitioned. Unemployment started after the requisitioning of the small piles of supplies and the prohibiting of leather production, which led to the closing of even those few tanneries that still remained in Krinki. Free movement was restricted and a special permit had to be acquired if someone wanted to leave the town for example. It was prohibited to take in and out of town, food an other products of primary necessity, etc.
Commerce came to a standstill. Many shops and businesses had been plundered during the retreat of the Russians and most of the remaining goods were soon requisitioned or bought up and what was left vanished due to all the smuggling and speculations that went on.
Serious food shortage, turmoil and immense scarcity sprang up. The Jews, young and old alike, set out to the nearby villages to get whatever products they could from the peasants, whose cattle and grain had also been confiscated by the Germans. People were lucky enough if they returned home with a little piece of hard village bread, a little barley or rye and the like for themselves and the rest of their household.
Even those who still had some savings soon lost it when the order was issued that all Russian rubles had to be exchanged into the worthless banknotes of the occupying power. An evil decree was also issued which ordered the selling of all copper products, (including household articles such as door-handles, frying pans and other tableware), to the German lord for almost nothing. The wind of poverty started to blow soon in the Jewish homes. The time of hunger and need arrived when, as Krinki Jews describe it in their memoirs, mothers and sisters, wrapped in tatters and with clogs on their feet, poured out of all corners of the town at daybreak and tread the fields for 20 versts (about 13 miles) to find a forgotten stalk of rye or a frozen rotten potato. Others also went to the nearby woods to gather a little waste wood to cook and warm themselves.
on the highway leading to Little Brestovitz
[p. 99]
Living under distress (The trades in the destitute times)
Meanwhile the Jews of Krinki did not sit idly. They sought ways to make both ends meet and endure the bad times. They leased orchards and gardens from landowners in the neighborhood of the town and dozens of families made a living out of growing potatoes for years. Others took up impromptu trades of the times: the more adventurous engaged in smuggling forbidden goods from one zone to the other, while the less daring became coachmen who transported these goods and made a living from this. It is true that some of them would have made a better melamed [teacher of children in cheder] than have anything to do with a horse and a coach, writes a Krinki Jew, but they did not have an alternative. People also tried to make a living out of other things as far as they could.
[p. 100]
Shmuel Geler: In the abandoned tannery yards (In the abandoned tannery yards)
When the front line approached Krinki during the First World War most of the leather factories evacuated into the heart of Russia. After the entry of the German troops into town, the remaining tanneries were closed, the factory yards were overgrown with wild grass. The raw materials were left lying around, the tanks were dry, the rolls and the benches were covered with cobweb.
The huge abandoned factory yards were a paradise for the cheder youth. There, they jauntily and happily played hide and seek, and Cossacks and robbers. The hundreds of poles left there served often as guns, swords and for playing devils.
D. R.-N.: The revival of Jewish culture (Jewish cultural resurrection)
Soon after the entry of the Germans in town, a radical change could be felt in Jewish cultural and social life in the nearby occupied territories. As the front line was approaching Krinki the Jewish members of the Russified circles were the first to leave the shtetl and go to the heart of Russia and those who remained were deprived of their spiritual nourishment. Russian language was withdrawn from circulation. The Germans banned it from the educational institutions and from social life in general and they even prefered Yiddish, which was close to their own language and which they thought could serve as a tool in Germanizing the population.
Yiddish, which the nationalist Jews had always regarded as a shield which protected the Jews from assimilation and as a natural tool for the development of Jewish culture, was maintained for some time, despite the general conditions.
The Jewish public, especially the youth, experienced not only bitter economic deprivation but also spiritual distress. People yearned for opportunities to enjoy themselves and drive away the oppressive mood, hear a little Yiddish and gain some spiritual pleasure.
When the Germans started to allow the organization of various performances the income of which was to be donated to help the needy, the Jews of the nearby towns and shtetls soon set up associations to cultivate Yiddish arts and drama, at first with the above-mentioned aim.
In Krinki, too, a Literary Society was quickly founded by leaders of various social groups, and literary evenings and other events were organized. The association set up a drama circle which ventured to produce plays in Yiddish a delight that the Russian regime had forbidden and that the Jewish public had not tasted for years. A fresh spirit entered the shtetl and reached even those who had until then been far from Yiddish culture in all its manifestations.
with their teacher Potshebutzki
[p. 101]
Beside their activities in the general Literary Society and in the drama circle, the Zionists, especially the youthful Tzairei Zion, which had organized itself undercover in the meantime, also opened a special gathering place, the Center. This label served as a disguise under which illegal Zionist activities were carried out as far as it was possible in those times.
Young teachers and activists undertook, with a lot of energy and devotion, the education of Jewish children The Hebrew elementary school was opened again and later a Yiddish elementary school was also established by labor leaders. Meanwhile, however, the occupying forces looked around and opened their own schools where teaching was in German with the intention to abolish Jewish education. The Germans demanded the introduction of German as the language of instruction in the Jewish schools and when the Jews resisted this they closed the Jewish elementary schools, although this did not make the German schools more successful. The Jewish schools opened again later.
The Literary Society also suffered from the occupying power. The situation changed only after the revolution in Germany at the end of 1918.
Yisroel Veyner:The Literary Society and its fight [1] (The literary society and its struggles)
It is 1916. We are in the middle of the First World War. Krinki, like all Lithuania, is occupied by the German army. An intensive cultural revival can be felt in almost all the towns and shtetls and Krinki, of course, cannot lag behind. A Literary Society was founded in our town at once under the leadership of the brightest forces, such as the teacher Eynshteyn, Dovid Gotlib, the Potshebutzki brothers, and others.
The society started to develop a wide variety of activities, organizing frequent literary evenings, at which lectures on literary topics and social questions, as well as recitals and recitations, and readings were held. The cultural elite of Krinki Jewish society participated in these events. The evenings always attracted a large audience, which greeted each performance with great applause. This audience, however, started to demand serious programs, such as lectures, recitals and recitations, because it badly needed culture and literature in order to drive away the hunger and poverty, which reigned in the town. An amateur drama circle was formed and it produced plays in Yiddish under the guidance of the Literary Society at the local bank.
[p. 102]
I remember to this day the first play of Yakov Gordin that we staged, Kashe the Orphan, in which Trakhtenberg was played by Eynshteyn the teacher, Matie Shtreykhl by Shmuli Tenor, as we used to call him, and Kashe the orphan by Rokhl Stambler.
The performance was a great financial and moral success.
The theatrical evenings were also attended by the German military personnel stationed in Krinki and in the nearby villages, as well as in the Lishk manor and in Alekshitz where they were quartered. The Germans stationed in Krinki were even interested in the performances and they often intervened in the direction of the play. Once at the performance of Hertzele the Aristocrat, they even forced Rokhl Stambler to sing Schubert's serenade at the end of the play.
The Germans are victorious
The Germans soon became jealous of the pleasure the Jews took in the performances and the overlord issued a strict decree that the management of the Literary Society should add a dance after each performances to make it possible for the Germans to dance with the Jewish girls. Unable to refuse, the management had to accept the decree against their will and for a few months each play finished with a dance for the benefit of the Germans who were very much attracted to the Jewish girls of Krinki.
However, murmuring started among the Jewish people of the town against such entertainment, at first quiet but getting ever louder. Scandalmongers took the opportunity to intrigue and exaggerate what really happened. The management of the Literary Society was powerless. They could not put an end to these dances because repealing the decree of the German military power in wartime would have entailed the death penalty or at the very least being sent to forced labor in Heynovke or Bialoviezh. There seemed to be no way out.
Then comrade Dovid Gotlib, chairman of the Literary Society announced in a meeting of the management that he would not allow the dance after the next performance and would assume responsibility for it. All members of the management tried to dissuade him, warning him of the great danger that such an act might bring, but nothing helped. He stubbornly stuck to his own opinion. And so it was: when a new play was put on and at the end of the performance people started making room for the dance, Gotlib got on the stage and gave out strict orders that nobody was to dance and have boisterous festivities at a place where Mendele, Peretz and Sholem Aleichem was recited.
[p. 103]
The Germans were stupefied as if struck by lightening. How dare that filthy 'Ostjude' [East European Jew] oppose the omnipotent Germans!, they said to themselves. Comrade Gotlib took advantage of the confusion to disappear from the hall with some of his comrades.
When the Germans recovered from their astonishment, they started to look for Gotlib in order to take revenge on him. Late at night they invaded the house of Dovid's father, Reb Yudl Gotlib, peace to his memory, and other Jewish houses, too. As they did not find him, the German police announced to the Literary Society the following day that if Dovid Gotlib did not surrender himself in six hours, all the members of the society's management would be arrested and the society would be abolished. Precisely six hours later Dovid Gotlib showed up at the police station and he was arrested.
When the authorities tried to decide later what punishment he should get, the police sergeant Grabak, demanded the highest punishment. A series of mediation started then trying to influence the head of the office and other circles, and they finally agreed to just sending Gotlib to Heynovke. But Gotlib was unexpectedly saved by his cousin Batsheba Mordekhailevitz who was on friendly terms with the secretary of the head of the office, Shturmak, a deeply religious German Jew, graduate of a rabbinical seminary. (They got married later.) No effort was spared and Dovid Gotlib was finally rescued from the clutches of the German military.
However, he was freed on condition that the Literary Society would call together an exceptional general meeting at once and not only relieve him of the chairmanship but exclude him from the society altogether. The meeting took place two days later and all members of the society, as well as several representatives of the German occupying forces participated in it. The meeting was presided over by the vice-chairman, Anshl Potshebutzki, who explained to the assembled why the meeting had been convened. For the sake of the continued existence of the Literary Society he asked those present to vote for the dismissal of Dovid Gotlib from the chairmanship and his exclusion from the society by raising their hands. But nobody raised their hands.
Seeing this, the chief representative of the Germans warned the assembled that they must find a way out; otherwise sanctions would be applied against them. Gotlib himself intervened, however, to save the situation and implored the assembly to vote for his exclusion for the sake of the Literary Society. But the second voting could not take place because the firemen sounded the alarm this had been prepared by the Germans and their servants on purpose and the assembled scattered.
The Germans were victorious . . . Officially Gotlib was considered excluded from the society but in reality no meeting of the management, no discussion, no cultural event took place without Gotlib being actively involved in it. And he received dozens of letters from the nearby Jewish shtetls, which appreciated his courage, daring and fearlessness. This is how the Jewish youth of Krinki fought against the evil German power in 1916.
|From page 101: From the Grodno Echo, Buenos Aires, No. 10. Return
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text:
StatesTrivia brain teasers have some element of trivia in them, but they are not just pure trivia questions.
What is the only letter in the alphabet that is not in any of the names of the 50 U.S. states?
AnswerThe letter is Q.
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