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BOZEMAN – With results that run from rust-resistant wheat to glowing rodent cartilage to super fluorescent fruit flies, researchers at Montana State University have developed new technologies in the areas of biotechnology and agriculture that are patent-pending and available for licensing.
In MSU's College of Agriculture, researchers have developed rust-resistance in wheat, which could offer a solution to a spreading pathogen that has already destroyed crops in Africa and Asia. The non-genetically modified trait that has been re-created in varieties of wheat has shown resistance to a pair of rust strains – Ug99 and Yr27 – that have emerged in recent years. MSU has a patent pending.
Globally the three types wheat rust – stem, leaf and stripe rust – are the most economically damaging diseases that attack wheat. Epidemics often inflict heavy losses, sometimes wiping out 60 percent of a given crop. The development of rust-resistant varieties of wheat is estimated to have saved more than $1 billion annually over more than four decades.
In another effort, a research team in MSU's Department of Microbiology and Immunology working in the technology class known as CRISPR has found a novel way to turn genes on and off, which could lead to groundbreaking technologies in medical science and the pharmaceutical industry, as well as in the production of food and biofuels. MSU has a patent pending.
CRISPR-based genetic engineering tools are a recent breakthrough for controlling multiple gene functions in a range of plants, microorganisms, fungi and animals. Based on a genomic anti-viral defense response discovered in certain single-cell organisms, CRISPR stands for the DNA sequences featuring "clusters of regularly interspaced short palindromic repeats" that scientists have shown can be harnessed to target and destroy or activate specific genes in cells.
Based on a rapidly emerging area of genetic research that only began to take shape in 2011, CRISPR-based technologies offer gene-editing methods that cost less, take less time and are easier to use than other genetic engineering techniques.
In an important breakthrough, the MSU CRISPR sequence is different because it limits the effect on non-targeted genes, something that has proved to be a challenge to geneticists. The MSU technology has also shown an ability to control multiple selected genes simultaneously.
These abilities have promising applications for virtually any kind of genetic engineering and hold special potential for studies of disease, the development of antibiotic, anti-viral and anti-cancer drugs, the development of high-value, disease-resistant food and biofuel crops, among other areas of interest.
Another technology features a new way to test the effectiveness of drugs in treating osteoarthritis and other joint-degrading diseases. A team of engineering and immunology researchers developed a mouse with luminescent cartilage in its knees.
The cartilage genes of the mouse have been modified to include a firefly gene so that the areas affected by testing of osteoarthritis therapies light up and offer quantifiable data on changes to that cartilage. Previous methods for testing in mice have been limited because studying effects on mouse cartilage required researchers to euthanize the mouse. Other techniques also require expensive imaging equipment such as MRI. MSU's luminescent mouse model addresses these issues, allowing researchers to measure effects to mouse cartilage over time, noninvasively and through direct observation.
Given that 27 million people in the U.S. and 250 million worldwide suffer from this most common form of arthritis, MSU's new mouse technology comes amid ever-increasing efforts to develop treatments, and it solves a major bottleneck found by those researching drug therapies for osteoarthritis.
The new mouse model has been successfully bred and a patent is pending.
Researchers in MSU's Department of Cell Biology and Neuroscience have discovered a way to multiply the brightness of a fluorescent protein that has been used in tests on fruit flies. By cloning six fluorescent proteins into a Drosophila fruit fly, researchers were able demonstrate a dramatic increase in brightness that is visible to the naked eye.
Because many important biotechnology discoveries depend on the ability of researchers to observe cellular responses to environmental changes – how a cellular function is related to a specific disease – researchers use fluorescent proteins to report genetic response to different stimuli, such as drug compounds.
Since the effectiveness of commercial fluorescent proteins has been limited by how brightly they show their fluorescense, MSU's new technique for improving their brightness should be of interest to the biomedical industry. The method should be effective for a broad range of research organisms such as mice, worms, bacteria, zebrafish and flies. MSU has a patent pending.
MSU currently has 229 licenses on technologies developed by faculty. Of those, 72 licenses are with Montana companies.
The MSU Office of Technology Transfer has an application that will automatically alert people to new technologies. To sign up MSU Tech Alerts click the link at the bottom of the Office of Technology Transfer Office website or visit https://www.montana.edu/techalert.
Contact: Gary Bloomer, MSU Office of Technology Transfer, email@example.com, (406) 994-7483, or Nick Zelver, (406) 994-7706, email@example.com.


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look lets face it ppl im about to name wrestlers that need to be world champ. These guys are uniqe and very entertaning to watch both tna and wwe. Be warned some of the people on this list is a surprise but u will see why i chose them over a few common ppl that evryone usually name. These guys i belive have proven to me that they need to be champ. WWE:
6 The Big Show : He is the

subset: commoncrawl


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Alphorn T-Shirts are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Alphorn T-Shirt for a special occasion, give a Printed Alphorn T-Shirt as a present or need to represent with a funny Alphorn Tee during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Alphorn T-Shirt for you! Even if it turns out you can't find the right Alphorn Tshirt with the perfect design for your mother, father or children; Idakoos offers all of its men's women's and children's Alphorn Tshirts as Custom Alphorn T-Shirts. Personalize any Alphorn T-Shirt the way you want to ensure the perfect gift.
Showing 1 - 24 of 93 T-Shirt


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March 26, 2001 - 9:00pm
For those HL owners using CS Mod, make sure to use the HL auto update utility (you can get it here on MG). I used this tool myself and it works very well - especially if you're not sure which patch you need.
Keep in mind that there will be no CS mod 1.2, it will go right to 1.3. CS Mod 1.3 and CS Retail 22.214.171.124 will be out in a few weeks, if not longer. Remember that these are the patches that will incorporate Valve's new Voice Communication technology and multicast spectator.
Half-Life: Counter-Strike v1.2 Release Documentation -- Readme.txt [6.30.01]
Changes/Additions :
- Added Deathmatch Classic
- New Automatic update system.
- Fixed GL texture binding problem (white skin bug).
- Optimized model drawing.


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Click on the headline (link) for the full text.
Many more articles are available through the Energy Bulletin homepage
Gardener: Urban pioneer Greensgrow Farm leads by example
Joe Lamp'l, courier press
Just three miles north of downtown Philadelphia, tucked within a sea of tightly packed row houses, lies Greensgrow Farm. Much is crammed into this one-acre setting. And although there is a full-service garden center, it's the many other things going on there that have made the farm the nationally recognized leader in urban sustainable farming.
Ten years ago, the land where this urban farm now sits was an abandoned galvanized steel plant, hardly the kind of place most people imagine as an ideal site for growing fresh fruits and vegetables. But then again, most people aren't Mary Seton Corboy, the co-founder and visionary behind all that happens at Greensgrow. At the time she discovered this plot of land, Mary was looking for a place to grow fresh, locally grown lettuce to supply area restaurants that were craving produce harvested at the peak of freshness.
But there was one slight problem with this location. The soil had been contaminated by its former use; Mary had to come up with an efficient way to grow the lettuce safely and organically. Growing hydroponically aboveground and without soil solved that challenge. Soon she had perfected her techniques, and the demand rose for more varieties from Mary's urban farm. To solve the next challenge of growing crops that prefer soil to water, Mary created very deep raised beds and trucked in tons of soil. Her relatively small farm was now growing and supplying top Philadelphia chefs with everything from cabbage to carrots, tomatoes, peppers and even figs from trees growing in large containers.
As Mary continued to take on one challenge after another, she realized that her location provided an even bigger opportunity. By providing fresh fruits and vegetables to a community where access to such goods was very limited, it gave her the chance to share the bounty and touch the lives of her neighbors in an important way…
(15 Oct 2009)
Quick and Not So Dirty: No-Sweat Composters
Gwendolyn Bounds, Wall Street Journal
Last weekend, I fed my plants and vegetables some compost made from my kitchen scraps and yard waste. But I didn't spend months outside mixing piles of the organic brew with a pitchfork. Instead, I whipped up a batch in 14 days, with the push of a button—in my laundry room.
Call it speed composting. Manufacturers and retailers are rolling out gadgets that help consumers make compost faster, more discreetly and, in some cases, with less of the "yuck" factor. The move comes as more cities are encouraging and even mandating that residents who don't compost at home take time to divide their food and yard waste from other trash so it can be recycled elsewhere. Next week, San Francisco will implement a new rule requiring that its citizens separate such items into green "composting" carts or potentially face fines.
Compost is earthy material produced from the natural decomposition of organic matter such as grass clippings, leaves, vegetable remains, and coffee grounds. It's nutritious for plants and lawns and reduces the amount of trash sent to landfills. Yard trimmings and food residuals constitute about 24% of the U.S. municipal solid-waste stream, the Environmental Protection Agency says.
But many homeowners who readily recycle don't bother composting. (Guilty.) That's partly because it's more of a hassle than just tossing plastic bottles and newspaper into colored bins….
(13 Oct 2009)
How High Speed Rail Can Spread Across the U.S.
asladirt, The dirt
The U.S. High Speed Rail Assocation, a new group formed to advocate for high speed rail, organized a conference in D.C. attended by Congressional representatives, smart growth advocates, and Governor Ed Rendell from Pennsylvania, a leading high speed rail proponent. Rendell argues that a nation-wide high speed rail network is critical and called for a "dedicated federal government capital budget" to fund the program. "We have just been nibbling at infrastructure," Rendell argued. Rendell sees a dedicated "infrastructure bank," which would "take the politics out of transportation decisions," funneling funds to high speed rail, transportation rehabilitation, and transportation improvement projects. Rendell noted that the American Society of Civil Engineers said the U.S. needs to invest $2.2 trillion to ensure the country's future competitiveness.
In addition to strengthening the U.S. competitive position, Rendell argues that high speed rail would help restore the U.S. construction and manufacturing base, and "bring millions or tens of millions of jobs and new factories." Rendell compared current opposition to a country-wide high speed rail network to the early opposition against the Erie Canal. He noted that the $9 billion investment in the Erie Canal was repaid within nine years, and the investment helped revolutionize the U.S. economy.
In terms of high speed rail networks, the U.S. is falling even further behind other developed countries. Japan's already advanced network will add 16,000 miles of high speed rail line by 2020. Spain is spending $100 billion on another 6,000 miles. While the U.S. spends 2.5 percent of its GDP on infrastructure, Spain is spending up to 10 percent. The U.S. has spent $1.3 trillion on highways, but only $53 billion on passenger rail.
While the Obama administration has put $8 billion in recovery funds and $5 billion of the budget towards high speed rail, this will really only help in planning and making relatively minor improvements to existing networks. Rendell fears much of the funds have already gone to mid-speed rail. California alone requires $45 billion for their high speed corridor plans, which would run from the northern to the southern part of the state…
(22 Oct 2009)
"Agriburbia" sprouts on Colorado's Front Range
Jason Blevins, The Denver Post
Six years ago, Matthew "Quint" Redmond suggested to Milliken planners that a corn farm north of Denver could increase its agricultural value and still anchor nearly a thousand homes.
"I got laughed out of the room," Redmond said.
Today, Milliken's 618-acre Platte River Village is ready for construction, with 944 planned homes surrounded by 108 acres of backyard farms and 152 acres of drip- irrigated community farms. The plan is for the farms to feed local residents and supply restaurants while paying for community upkeep. And Redmond, a 47-year-old planner-farmer, has 13 other Front Range projects mulling his "agriburbia" concept.
Redmond, co-founder of the Golden-based design firm TSR Group, travels the country preaching his urban farming and development idea. He envisions a future where the nation's 31 million acres of lawn are converted to food production. He sees golf-course greens redefined with herbs; sand traps as "kale traps." He sees retirement homes engulfed by farms and office buildings where workers escape cubicles on farming breaks.
Redmond, along with his born-on- a-farm biologist turned planner wife, Jennifer, sees an urban landscape like none before.
"This is where we are all going to go. We need this," said Redmond. "Everyone thinks they are so smart by crafting a 2030 plan for the future. I say we need a $180-a-barrel plan, on how our communities can be self-sufficient when oil becomes too expensive to ship food across the country."
Self-sufficient. Sustainable. Locally produced. Agriburbia incorporates all three concepts…
(24 Oct 2009)


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DEAR JOAN: Recently, we rented a house near Lake Tahoe in a community surrounded by woods. On the last morning of our stay, I took my two small dogs for an early walk about 8:30 a.m., and let them walk without a leash as the streets had been plowed from earlier snows and there was a 5-foot wall of snow on either side of the street.
There was no one around, and no car in sight, and as we walked down the street it was quiet enough to hear a pin drop. As we neared the next corner, I suddenly heard the loud howls of what sounded like a pack of coyotes, coming from the woods right behind the houses. I became very concerned about my dogs, scooped one of them up and got the other one to quickly follow me as we turned and walked rapidly back to our house.
Is it unusual for coyotes to be howling like this in the morning? Do you think the presence of my dogs could have prompted it? Was I right to be concerned about them possibly going after my small dogs, even with me there?
Regina L.
DEAR REGINA: Coyotes normally hunt from dusk until dawn, but it's not unusual for them to be out in the day. I suspect they had killed or found something tasty and weren't about to let morning them stop them from getting a good meal.
You were right to protect your dogs and beat a hasty retreat. The coyotes likely wouldn't have bothered you or the dogs if their attention was focused on a meal in front of them, but they might have attempted to protect it.
It's always a good idea to keep your dogs leashed and under your control and protection, especially in an area that wild animals call home. Hawks have been known to grab small dogs and while it was far too cold for snakes to be out, they can be a problem as the weather starts to warm. They crawl out looking for some sun and all it takes is a curious dog sniffing in the wrong spot to create trouble. Dogs can also end up injuring wildlife. I'm glad this was a happy-ending story.
DEAR JOAN: One of our neighbors has chickens and a rooster. I know having chickens in San Jose is OK, but I thought having a rooster was a no-no.
Mr. Rooster starts crowing most mornings about 6:30, sometimes a little earlier, and can continue crowing for hours.
We are within San Jose city limits, and other than talking with Mr. Rooster's owners, which other neighbors have tried, what can we do to return a little quiet to our mornings? Will code enforcement come out for the rooster?
Ellie J.
San Jose
DEAR ELLIE: In San Jose city limits, people can own up to six chickens, but they are not allowed to keep a rooster older than 4 months.
Many times, people selling chickens aren't good at sexing them — something that can be difficult when they are chicks — and so your neighbors may accidentally have gotten a rooster and are now so in love with the guy they don't want to get rid of him.
It actually will be to their advantage to do so, however. A rooster is not required for the hens to lay eggs — only to fertilize them if they want to raise more chickens, and because there are restrictions on the number of chickens one can have, that doesn't seem practical.
If talking to them hasn't worked, then yes, you can call code enforcement or animal control.
Keeping roosters is against the law and while they may not rush out, they will eventually deal with the violation.
Joan Morris' column runs five days a week in print and online. Contact her at firstname.lastname@example.com; or P.O. Box 8099, Walnut Creek, CA 94596.


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We look at the youth movement in cigars, from the fifth generation of Quesadas, to the Perez-Carrillo children and the Levin young guns at Ashton.
(continued from page 2)
At three prominent cigar companies, this next generation of cigar personalities—many of them female—is beginning to make their impact on the industry. And some have already created their own cigars.
The Quesadas — The Fifth Generation
The most dramatic youth movement in the cigar industry is happening in Santiago, Dominican Republic, inside the wood-paneled walls of Manufactura de Tabacos S.A., or Matasa. This 35-year-old company, the first to roll cigars in Santiago's original free trade zone, is operating more and more under the influence of five 20- and 30-somethings who 63-year-old factory owner Manuel (Manolo) Quesada collectively refers to as "the young ones." They also go by the term "the fifth generation," as they are the fifth generation of Quesadas to work in the tobacco business.
"The young ones," says Manuel Quesada with his typical deadpan humor, "are building the pillars for my monument."
Ranging in age from 24 to 33, the youngsters have injected new life into the company. They are led by Quesada's two daughters, Patricia, 33, and Raquel, 31, attractive blondes with generous smiles and Blackberrys that sometimes seem to be living extensions of their arms. Patricia, who calls herself "the spokesperson of the fifth generation," focuses on administration, while Raquel spends most of her time on the production floor. Manuel Quesada's niece, Esther Quesada, 32, runs the tobacco farm and the leaf warehouse. Nephew José Manuel Bermudez, 28, known as Blondie for the color of his slicked-back hair, designed the company's Casa Magna label. He runs the box factory with help from Hostos Fernandez Quesada, 24, a slim, bespectacled nephew who just graduated from college and has a knack for technology. The newest member of the next generation, nephew Terence Joseph Reilly, joined the group just this summer, bringing the total from that generation to six.
With a father and grandfather running a cigar factory, Patricia and Raquel have been around cigars all their lives. They visited Matasa from an early age as well as the tobacco fields run by their uncle. Patricia has worked for the company longer; she began in late 1997, starting "at the bottom," going through each department, even cleaning floors, before settling in administration and accounting. Raquel started in 2000 and soon showed a knack for blending a cigar, participating in the blending of the Matasa 30th Anniversary, the Fonseca Cubano Viso Fuerte and the Fonseca Cubano Limitado, where she has taken "top billing," on the box, says her father. "Raquel is the second in command in the factory," he says.
Raquel has even been known to do more than a few things without her father's consent, which inevitably leads to discovery, then a dreaded page over the Matasa public address system. Patricia mimics her father's voice, describing what happens: "'Raquel Quesada, extension 23.' When you hear that," she says, beaming, "go the other way." The girls also reveal that their father's bushy salt-and-pepper mustache has a habit of going up when he's angry.
So what gets her in trouble? "She changes my blends," Manuel says with a laugh. He says that he selects a blend, instructs Raquel to have the factory make it, then when she brings him a finished cigar (naturally leaving his office posthaste) he notices the difference when he takes a puff. That's when he reaches for the P.A. Later, he usually realizes that the change is beneficial. "It's OK," he says, showing considerable fatherly pride in his little girl's knack for making a cigar.
There's just the hint of good-natured sibling rivalry between the sisters. "Patricia is the one who always got what she wanted from my father," says Raquel, smiling. "I got everything from my mom." Patricia smiles as well. "I know when he says 'no' how to get a 'yes.'" Raquel calls her father "Quesada" at work, something Patricia cannot do—"I call him Papa," she says.
While there were some dispensations made because they are female ("I used to work summers, and my mom would call the factory and say 'Is she sweating? I don't want her to sweat,'" says Raquel) the women say their dad is demanding. "Even though we're girls, he still expects a lot," says Patricia, describing 12-hour days and 10 p.m. work calls.
The fifth generation wasn't supposed to be this deeply involved in Matasa, certainly not this soon. But in 2002, everything at the company changed forever. The plane was a small Cessna, and it set out from Santiago on the morning of April 17, bound for Haiti. The weather turned, and contact with the plane was lost. The following day, the downed aircraft was spotted atop Mount Pelona, one of the tallest mountains in the Caribbean.
All four aboard the plane were lost: Manuel's brother, Alvaro Quesada; his son Alvaro Jr., Julio Fajardo and the pilot. Fajardo was Manuel Quesada's right-hand man at Matasa, and the heir apparent to the factory. Alvaro Jr., 24 at the time, was being trained to one day take his place.
"When we lost half of our staff in 2002, we all knew we would have to pull together, but at first we had five years not even thinking about it. We were on autopilot for about five years," says Patricia. "A year ago [the members of the fifth generation] started having meetings once a week, without my father. There, we talked about how the industry has changed."
The fifth generation took a hard look at stronger tobaccos, the type of thing that just wasn't used very much at Matasa. The result is in the company's newest cigar, the Quesada 35th Anniversary, which was created collectively by the youngsters.
One day, the five called Manuel Quesada into a meeting room, and presented him with a tray of five cigars. They told him they were the blend choices for the 35th Anniversary. "I said, 'I thought I was doing that,'" says Quesada. He started smoking. They started tweaking. "And they were the ones doing the tweaking. It was very refreshing," he says, calling the moment both proud and scary. "It's a cigar that the fifth generation decided to do on their own. Unfortunately," he says with a laugh, "I didn't have anything to do with it." The cigar is a milestone, not only for the considerable involvement by the youthful members of the Quesada family, but for its name. While the Quesadas have rolled cigars in the Dominican Republic since 1974 (before any member of the fifth generation was born), this is the first time the family name has appeared on a brand.
The squared-off cigar is made with a combination of Nicaraguan, Dominican and Ecuadoran leaf, including a wrapper that is grown in Ecuador from Arapiraca seed, which is usually grown in Brazil. "It's totally different—we have never used these tobaccos at Matasa before," says Raquel Quesada. Adds her father: "It's a radical departure from the blends that the old man has been doing." The cigar was previewed at the Madison Avenue Davidoff store in New York City on June 29. All six members of the fifth generation lined up to present the cigar as Patricia took to the microphone. Manuel stood far to the right, separate from the group, letting his daughters, nephews and niece bask in the glow of their creation.
"Tobacco has been an essential part of our lives since the day we were born," Patricia said to the crowd. "The love for tobacco, and this industry, is something we all carry in our hearts, our souls, and even our senses, and that is what has kept us going, and will continue to keep us going for more generations to come."
In a private moment, the two sisters reflect on the journey the fifth generation at Matasa has taken, particularly the female contingent. "I think a lot of men did not take us seriously at first," admits Patricia. Now, she says, "They see we do know something." Then she exhibits some of the humor she has inherited from her father. "We're not just blonde."
The Perez-Carrillos — Life After La Gloria
It's not easy to walk away from one of the best-known cigar brands in the world. Moving into the arms of your children makes it easier. In March, 57-year-old Ernesto Perez-Carrillo left the La Gloria Cubana brand, the cigar that was the hottest cigar brand in America in the early 1990s. Perez-Carrillo left to work with his children, daughter Lissette, 35, and son Ernesto Perez-Carrillo III, 27.
"One of the main reasons I decided to leave is that my children want to get involved with the new company," Perez-Carrillo said at the time. "The opportunity to work with my kids is a once-in-a-lifetime opportunity." His daughter worked as a lawyer, his son was a private equity executive with Kohlberg Kravis Roberts & Co., the famous leveraged buyout firm. They are "two of the people that I trust most in my life," said the elder Perez-Carrillo during a family lunch in late June. Though eight years separate his children, they could almost pass as twins with their jet-black hair and lean frames. Lissette has her father's intense, piercing dark eyes and both have inherited his distinctive jawline.
In the late 1970s, when La Gloria was largely unknown outside of the Little Havana neighborhood in Miami where it was rolled, young Lissette would watch her father work and sometimes lend a hand. "As a child I would go to the factory very often," she says. When she was five, six and seven, she would band cigars, and put them in cellophane. As a tween, she would work on customer lists, then later she went to trade shows. All that time spent in a cigar factory had an impact, imparting upon her a knowledge of Cuban slang that perplexed her friends. "These colloquial Spanish terms—my friends would say, 'How do you know that?'" she laughs.
In college, Lissette helped her father and mother with shipping cigars, and took orders over the phone, particularly when a certain cigar magazine profiled La Gloria's then small operation in Miami, running a photograph of the family. "It was surreal—the phones wouldn't stop ringing," she says.
|When Ernesto Perez-Carrillo left his La Gloria Cubana brand in early 2009, he turned to his son Ernesto III and daughter Lissette for help in creating a new venture making E.P. Carillo cigars.
Like their father before them, Lissette and Ernesto III were encouraged to seek their own careers, not just join the family business. Their cigarmaker father tried a stint at drumming before dedicating himself to the cigar business, thumping the skins for several bands, including Tu Madré, and The Shadows (who once opened for KC and The Sunshine Band). "They were going to do their own thing," says Perez-Carrillo. "It's good to let kids go and do what they want, like when I wanted to be a drummer—now there's no looking back in regret."
Lissette went to law school, got married and had two children; Ernesto III began working in private equity and consulting. Each hoped to return to the La Gloria business. "I was the only one [in law school] who said my goal was to go back to Miami and run a cigar factory," says Lissette.
But the business had changed—production of La Glorias soared after 1995 when, to meet burgeoning demand, Perez-Carrillo began rolling cigars in the Dominican Republic on a scale six times larger than at his tiny Miami facility. Then the offers came rolling in. Ernesto Perez- Carrillo fielded six serious offers for his El Credito Cigars Inc., and finally sold his company to Swedish Match AB (now the parent company of General Cigar) in 1999 for an estimated $40 million. Even though the numbers involved were life-changing he labored over the decision to sell (Perez-Carrillo had even turned down a larger offer).
"He tried to find every excuse not to do it," says Lissette. Admits her father: "It was hard for me to sell the business at first."
But Swedish Match didn't just want the brand—they wanted Perez-Carrillo to continue making it. Soon Swedish Match acquired General Cigar Co., the maker of Macanudos, and El Credito became a part of General. Having the much bigger company's sales force behind him helped move La Glorias at an unprecedented rate.
However, his being a part of a big company eventually chafed at Perez-Carrillo, and he yearned to do things on a smaller scale once again, this time with his family. His artistic creativity needed to be stirred.
"It's very exciting," says Ernesto Perez-Carrillo III. "It feels good to build something from scratch together. The whole family is really getting behind it…. We're all chipping in. We each have things to bring to the table." Ernesto III will focus on building the customer base, particularly in the New York area, where he lives. His sister will do all the legal work for the company, and is setting up the warehouse and offices in Miami, her home. "I'm going to be servicing all these orders Ernie's going to get," she says with a smile, giving her little brother some good-natured ribbing. She also intends to set up a smoking lounge in the company headquarters, just minutes from historic Calle Ocho.
The elder Perez-Carrillo is focusing on cigars and the tobacco needed to make them, and his children know they have a long way to go before they can take up his blending reigns. "He's the cigar man," says his son. The father has embarked on a tobacco-buying spree. By late June, he had already bought tobacco from six farms in Nicaragua alone, and he was planning on buying more. "In October and September, we're going to go out and buy a lot more tobacco," he says, puffing on a prototype smoke.
The children won the first battle with their father, convincing him to move at an accelerated pace to get the business started. Perez-Carrillo originally didn't plan on having a cigar out until 2010, but the new plan has them on pace for a November or December 2009 launch. "The plan was to start in March or April [2010], set up the factory slowly, make cigars for other people," Perez-Carrillo explains. "We're working on the factory now."
The brand will be their own, and will be called E.P. Carrillo. The first will be available in a limited-edition version (bearing a second band reading "Edición Inaugural 2009") and made with low-yield tobaccos. The core brand will come on the market later. "The plan is to do one limited edition per year," says Ernesto III.
The father, son and daughter trio is clearly excited about building a new brand from scratch together. "We've come closer together—I was always traveling," says Perez-Carrillo. Now, times are more like they were in the old days, when he worked in Little Havana and home was just a short drive away. "Our first house was very close to the factory," says Lissette. "My dad picked me up from school and we would go back to the factory. Anything we needed, he was there."
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Can Rado replace Edwards or maybe even DD as a 4-5 min/game fill-in?
From Pacer.com (or do they need look elsewhere, or not at all?)
Radojevic Eyes NBA Return
By Conrad Brunner | July 13, 2005
Not that long ago, Aleksandar Radojevic was one of the hottest prospects in basketball, a young 7-3 center with agility and shooting range who drew comparisons to Zydrunas Ilgauskas.
That's what compelled the Toronto Raptors to make him a lottery pick, No. 12 overall, in 1999. He was, in fact, the first center drafted that year.
Shortly thereafter, everything began to go wrong, primarily with his health. Now, six years later, he finds himself battling with other summer campers just to get a shot at a full-time NBA job.
"I just have to show them that I'm healthy, because I had a health issue before I left the NBA," Radojevic said. "And I have to show them that I'm fighting and I can do the parts of the job. They have big guys here. They just need a few guys to fill in while the other guys are resting, whether it's two, three, five minutes whatever it is. I just think I need to play strong every day and make the best of it."
Radojevic went on the injured list two games into his rookie season with torn cartilage in his left knee. Then came the discovery of a herniated disc in his back that resulted in two major operations that cost him most of the rest of his rookie season and all of 2000-01. He was traded twice while injured, to Denver and then Milwaukee, but never played for either team.
Considered damaged goods by the NBA, the native of what is now Serbia-Montenegro returned to Europe to rebuild his career. A brief trial with the Utah Jazz last season gave him hope that this time, with the Pacers, he can make it stick.
"I just want to stay in the NBA," he said. "I've been to Europe and it's a different story. My wife is American and I can spend more time here. That's what I'm looking for. When I'm in Europe, we have a 9-year-old daughter who's going to school and two sons and it's hard for me to leave my wife with three kids here. So three kids here and I'm in Europe by myself. It's not easy. For her, it's terrible. I just don't want to go through that anymore."
After averaging 8.2 points and 7.9 rebounds for Prokom (Poland) in 2003-04, Radojevic opened the 2004-05 season on Utah's roster. He lasted until Jan. 5, just five days before the deadline when contracts must be guaranteed for the rest of the season. He returned to Poland and helped his team win the national championship.
The Pacers, who worked out Radojevic before the 1999 draft, kept track of his career and extended the summer league offer. He'll travel to Minneapolis for five summer-league games with the Pacers beginning Friday.
"He's showing some promise," said assistant coach Dan Burke. "He can plug up the middle on defense. Offensively, he's got a knack for making the right pass, and he can see the floor. He's just got to play more like a 7-footer, play strong inside when he posts up, and to attack more when he gets the ball.
"We were intrigued enough to keep him and bring him to Minnesota and we'll see how he does. The game's going to be fast up there because the summer league is just that way. It's a guard-dominated game. We'll see how he does with that kind of pace."
Though his health problems are in the past, Radojevic admits the surgeries took their toll on his game, but he believes he has made the requisite adjustments.
"The past four years, I haven't had any problems, (but) injuries did their job," he said. "I don't think I could be the same player as I was but I'm more experienced, certainly. I can never maybe jump as much or be as mobile as I was, but I can run the floor pretty well."
He'll get his chance to demonstrate his ability to contribute in Minneapolis.
"You're always looking for good big men," said Coach Rick Carlisle. "He has some experience and so far he's been solid. We'd like to see him be able to score a little in the post, be able to block some shots and get defensive rebounds and basically play a good complementary game relative to the team and I think he can do that."
As things turned out, the only similarities between Ilgauskas and Radojevic were health problems. Ilgauskas came back from chronic foot injuries to become an All-Star. Radojevic has his health. Now, he's just looking for a job.


text:
Hello people,
I'm working on the following form where i am validating using an Ajax call.
Take a look at the following page
If you click in the required fields and then click out of them it should validate them. Let's take "First Name" for example. If you click into the text box and then click out of it without filling in any details it will show you a "Enter Details" image..
This is fine, but when i then fill in the details and click away again i am having a problem where the "Enter Details" does not change?
You can locate the ajax JS file here
The Join Now button is disabled by default, it should only be enabled when all the Required fields have been entered.
The ajaxValidatephp code page is shown below:
* This is the PHP script to validate the form over AJAX
* Validations types possible:
* - alpha
* - alphanum
* - date
* - email
* - number
// Start the main function
function StartValidate() {
// Assign some var's for the requests
$required = $_GET["required"];
$type = $_GET["type"];
$value = $_GET["value"];
// This is the function to check if a field is even required or not
// So it's useful if you only want to check if it isn't empty
validateRequired($required, $value, $type);
switch ($type) {
case 'number':
case 'alphanum':
case 'alpha':
case 'date':
case 'email':
// The function to check if a field is required or not
function validateRequired($required, $value, $type) {
if($required == "required") {
// Check if we got an empty value
if($value == "") {
echo "false";
if($value == "") {
echo "none";
// I use regular expressions in order to check a field's input, you can
// get most of them at the Regex Library at http://www.regexlib.com
// There you can check your own regular expressions, too
// Validation of an Email Address
function validateEmail($value) {
if(ereg("^([0-9a-zA-Z]+[-._+&])*[0-9a-zA-Z]+@([-0-9a-zA-Z]+[.])+[a-zA-Z]{2,6}$", $value, $regs)) {
echo "true";
} else {
echo "false";
// Validation of a date
function validateDate($value) {
if(ereg("^(([1-9])|(0[1-9])|(1[0-2]))\\/(([0-9])|([0-2][0-9])|(3[0-1]))\\/(([0-9][0-9])|([1-2][0,9][0-9][0-9]))$", $value, $regs)) {
echo "true";
} else {
echo "invalid";
// Validation of characters
function validateAlpha($value) {
if(ereg("^[a-zA-Z]+$", $value, $regs)) {
echo "true";
} else {
echo "invalid";
// Validation of characters and numbers
function validateAlphanum($value) {
if(ereg("^[a-zA-Z0-9]+$", $value, $regs)) {
echo "true";
} else {
echo "invalid";
// Validation of numbers
function validateNumber($value) {
if(ereg("^[0-9]+$", $value, $regs)) {
echo "true";
} else {
echo "invalid";
Can anybody see where i am going wrong?
Even something to point me in the right direction will be much appreciated.
Many thanks,
I've managed to solve the initial problem.
Only issue with this now is that the Join Now button enables it self when correcting one field :mad:
If I'm interpreting what your code is doing correctly, you're enabling the 'Join Now' button if there are no errors in the vError array, and you check that if whatever you're currently validating is valid. The problem is that you start the array off empty, so if the user simply enters their first name, which validates correctly, the join button will be enabled because there won't be any errors listed in the array.
To fix this, initialize the array to have an error for each of the required fields, which will then be eliminated one by one as the user fills out the form correctly. You may also want to display the error images in those fields as well to start off with, but that's up to you.
Any chance you could give me a pointer on where this needs to be done? I'm not so sure how to go about doing this,
Do you mean setting it to vError = ""; at the top?
No, I actually mean the opposite. Like I said, because your vError array starts out empty, if the user only enters information into one field, your code will test that field, and if it's ok, it then checks if the vError array is empty. Since it's empty, your code assumes that everything is filled in properly, so it enables the 'Join Now' button.
Since that isn't what you want, you need to first initialize the array with all the IDs of the required fields. So, at the top of your code where you define vError, instead of doing this:
vError = [];
It should look like this:
vError = ["billing_first_name", "billing_surname", "email", "billing_address_1", "billing_city", "billing_postcode", "password", "password2"];
Alternatively, since I see that you're referencing jQuery at the top of the page (though it should probably be updated from 1.3 to 1.6), you can do the following instead, which will always insert an error for every required field, even if you add or take away one or more of them:
vError = [];
$("#registrationForm input:text.required").each(function() {
Now, with the vError array initialized with an error for each of your required fields, the user must fill in all of them correctly before the 'Join Now' button is enabled.
Also, while your declaration of the global variable vId within the function validateIt is valid and successfully makes it available to other functions, it's easier to read the code if all global variables are declared initially at the top of the script, and maybe with some documentation as to what it's being used for. Though I don't think it even needs to be global, I'm guessing the only reason it is is because you can't pass it to handleHttpResponse in this statement since you're only allowed to specify the name of the function:
http.onreadystatechange = handleHttpResponse;
A way around that is doing this instead:
var handler = function() {
http.onreadystatechange = handler;
And then of course telling the handleHttpResponse function it needs to accept a parameter, which you can then use in place of the global variable inside the function.
Also (sorry, this is getting long) you can simplify the code that attaches JavaScript to your input fields using jQuery. Instead of setting the window.onload attribute and using the function getForm(), you can do the following:
$(document).ready(function() {
$(":input").blur(function() { validateIt(this); });
You can put anything else that should be done when the page loads into that document.ready function as well.
Let me know if you have any other questions/problems.
Hello again,
Firstly, thank you so much for helping me out with this i really appreciate it.
OK i have added your code, only thing is now, when i enter the First Name, Last Name, Email Address, Phone Day, Phone Eve the Join Now button becomes enabled
Not sure as to why this is, could you possibly take a look at the ajax Javascript file as i may have put something in the wrong place?
Do let me know if you spot anything
Much appreciated and thanks again...
It looks fine besides one thing: make the handleHttpRequest function take a parameter:
function handleHttpRequest(vId) {
I was getting an error since vId wasn't defined since it wasn't specified as a parameter.
Also, I discovered that the jQuery selector I gave you for getting all the required fields isn't working, it isn't selecting any of them. I played around with a few different selectors, and this is the only one that selected all of them correctly:
"#registrationForm input[class*=required]"
So put that in place of the other one, which was: "#registrationForm input:text.required".
Also, in the document.ready function, that selector should probably be "#registrationForm :text" rather than just ":input", since you only want to attach that event handler when text inputs lose the focus, not every input on the page.
Let me know if these changes work.
You do mean the handleHttpResponse here don't you? I have tried with your code but still it does not seem to work. Just so you know, in the <head> tag you will notice i do this:
$('#joinbutton').attr('disabled', 'disabled');
$('#joinbutton').attr("src", "<?=__SITE_PATH?>images/join-now-button-disabled.png");
$('#joinbutton').css("cursor", "default");
So that the Join-now button is disabled by default. Should i just do this in the CSS or leave this as is?
Nevertheless the changes i have made to the ajaxFormValidate file don't seem to be working as intended. Another thing i am cautious about..
$("#registrationForm input[class*=required]").each(function() {
There are other classes apart from "required". If we look back at the registration page we will see there are the following:
Would the above makee a difference to the way anything is working from the code you have suggested?
Sorry about this by the way, really appreciate the help
Oops yes, I meant handleHttpResponse.
Also, a couple things I noticed:
You shouldn't validate the address line using the type "alphanum", which makes it only able to contain letters and numbers. Addresses contain spaces and punctuation, too.
In the handleHttpResponse function, when you add an id to the vError array, make sure you only add it if it isn't in there already. Right now, if I click in and out of one of the required fields five times, its id ends up in the array five times, meaning that if I end up do eventually typing it in correctly, the only way I can remove it from the array completely is by typing it correctly five times. To fix this, just check whether the id is already present in the array (vError.indexOf(vId) will do the trick).
You can leave the stuff in the head as is.
The other classes don't matter, all that matters are the ones with a class of "required", regardless of whatever other classes those elements have.
If you make the two changes I noted above, I think it should work. Again, let me know if it doesn't.
Did you mean like this:
function handleHttpResponse(vId) {
if(http.readyState == 4) {
if(http.responseText == "none") {
document[vId].src = siteURL + "images/blank.gif";
if(http.responseText == "false") {
document[vId].src = siteURL + "images/error_missing.png";
if(http.responseText == "invalid") {
document[vId].src = siteURL + "images/error_invalid.png";
if(http.responseText == "emailexists") {
document[vId].src = siteURL + "images/cushion.jpg";
if(http.responseText == "true") {
document[vId].src = siteURL + "images/error_tick.png";
// We do a check if our element is in the error array, and if
// so, we can delete it from the array
if(vError.indexOf(vId) != -1) {
var aId = vError.indexOf(vId);
vError.splice(aId, 1);
if(vError.length < 1) {
$('#joinbutton').attr("src", siteURL + "images/join-now-button.png");
$('#joinbutton').css("cursor", "pointer");
I have taken the vError.push(vId); out.. But its now acting weird with some fields, think i may may have made changes in the wrong place
Sorry, that's my fault, I wasn't specific enough.
When you call the indexOf method on an array, it returns the index of what you pass to it if the array contains it, or -1 if it doesn't.
So, what I meant was when you're about to add an error to the vError array, check to see if it's already in there using the indexOf method. For example, here's what you would do in the first check:
if (http.responseText == "false") {
document[vId].src = siteURL + "images/error_missing.png";
if (vError.indexOf(vId) == -1) {
Then do the same type of check in the other places that follow, where you check for values of "invalid" and "emailexists". Also, shouldn't you be adding an error if the response is "none"? For a required field, wouldn't a blank input be considered invalid?
That seems to work now
I had to add this in the Document.Ready as the type="password" was not being picked up:
$("#registrationForm :password").blur(function() { validateIt(this); });
Works perfectly now, only thing i found is when i changed the address1 class to "required" it doesn't pick it up. I noticed it's the only class of this type so maybe the required class on its own does not work? :eek:
Thanks again for your help so far
I have altered the code slightly to make the AJAX validation functionality re-usable..
All still works as expected but i have realized that input elements with class of type "required" does not work still.
That's because you need to have another class so the PHP script knows how to validate the data. If you only give an input field the class "required", the type parameter that you pass to the PHP script is "", which the PHP doesn't take into account, so you don't get any kind of a response that you can work with, which is why the address isn't working.
When I said not to use "alphanum" for the address, I meant that something else should be used in its place. So, in the address1 element, you should put the class "address" after "required", separated by a comma. Then, in the PHP script, modify the switch statement by adding the following case to the end of it:
case 'address':
Then, just like you have the other validate functions defined, you'll need to define the validateAddress function as well:
function validateAddress($address) {
if (preg_match('/^[a-zA-Z0-9\\., ]+$/', $address)) {
echo "true";
} else {
echo "false";
Notice how I used preg_match here to test the address against the regular expression and not the ereg function, as the other validation functions have done. That's because the ereg function is deprecated, so it's safer to use preg_match. To make your other validation functions safe, just replace the name of the ereg functions with preg_match, and get rid of the third argument to those function calls ($regs) and you'll be all set.
That should fix the address problem.
Also, I noticed that you're simply checking the password with 'alphanum'. Since you probably want your users to have passwords of a certain length, defining a 'password' validation type and adding a function in the PHP script that checks for a minimum length would probably be a good idea, just follow the steps I described for adding a validator for the address. You also probably don't want to limit what the user can enter for a password to just letters and numbers, as some people like to use special characters to make their passwords more difficult to crack. If you choose to stay with just the alphanumerical characters for valid passwords, then make sure to make a note of that near the password fields so that the user knows what they're allowed to enter.
Doing the same for the first and last names would be good too, since your code currently doesn't allow for a last name of "O'Neil" since it currently only allows for letters.
I seem to have broken it somehow It was working before and i've come to it now and it's not working.. Please help..
I was debugging the javascript and tried doing this:
$("#validateForm input[class*=required]").each(function() {
And i got no alert i think there may be a problem there?
Not sure what i've done to break this, i've been staring at the same code for too long now and can't spot anything..
Can you please help?
I figured it out..
When i changed the code so that i could use the validation in more than one place.. I didn't realise that one of the include files is a popup (When you click on the Login link)
That popup has a similar form and also has email and password. I think it was conflicting with that..
Did you make any other changes besides what I told you to do? I can't seem to figure it out either, though the selector I gave you is picking up two elements rather than 0, so two alert boxes pop up for me when I run code to have alerts come up showing every id that matches. Your code that shows alerts with "Hello" doesn't run though.
Like I said earlier, it can't hurt to update your version of jQuery to make sure that having an older version isn't what's causing the problem. In the line of code where you include jQuery in the head section:
<script type="text/javascript" src="http://ajax.googleapis.com/ajax/libs/jquery/1.2.6/jquery.min.js"></script>
Change the "1.2.6" to "1.6.2".
Also, delete the inclusion of jQuery version 1.3.2, there's no reason to have more than one version loaded.
Oh ok, yeah, that would do it. I'd still encourage you to update your version of jQuery though, since newer versions tend to be faster, have more features, fewer bugs, and better cross-browser support.
Thanks pal
I will do the jQuery update now I'm just getting into jQuery it's absolutely brilliant
Ok one thing i have noticed is that the Submit Button sometimes becomes enabled when all of the fields are not filled in..
Would you say there is a better method to take care of this? For e.g. not even showing the Submit button and showing it only when all the fields have been entered? What would be best from a users perspective?
Also for the password preg_match, would this do the trick?
function validatePassword($value) {
if (preg_match("/^[a-z0-9_-]*$/i", $value)) {
echo "true";
} else {
echo "invalid";


text:
NEW YORK ( TheStreet) -- Palo Alto Networks ( PANW), which made its debut as a public company in July, should be grabbing investors' attention in 2013. The security specialist, which competes with Fortinet ( FTNT) and Check Point ( CHKP) in the next-generation firewall market, is positioned to grab market share, analysts say. "We like Palo Alto Networks (PANW) as a way to gain exposure to Network Security, which we believe will be an IT category that outperforms in 2013," wrote Baird Equity Research, in a note released on Friday. "Importantly, the company is demonstrating an ability to broaden its footprint in Large Enterprise accounts (now the primary firewall in ~50% of deployments) and has noted good initial traction with subscription sales (additional features sold via SaaS)." Baird rates Palo Alto "outperform." Topeka Capital Markets on Friday initiated coverage of Palo Alto with a "buy" rating and a $65 price target. "We expect Palo Alto to couple rapid product revenue growth and improving revenue visibility with its even faster growing subscription/service business with significant operating margin expansion that will fuel 90%+ EPS growth for the next two to three years," wrote Topeka analyst Frederick Ziegel, in a note. "Since shipping its first security appliance in 2007, Palo Alto has helped pioneer the emergence of the Next Generation Firewall (NGFW) market that will, over time, replace large portions of the firewall, Intrusion Prevention and URL filtering markets as we know them today, representing an estimated $10 billion revenue opportunity." Palo Alto touts its PA-5000 products to protect data centers, large enterprise Internet gateways and service provider infrastructure, offering heavy-duty firewall technology, as well as threat prevention and Virtual Private Network (VPN) features. Initially, the Silicon Valley-based firm felt plenty of love from investors, pushing its shares steadily upward following its IPO last year. After pricing its offering at $42 a share, the stock climbed more than 35% to reach a 52-week high of $72.61 in early September. Like many tech stocks, however, Palo Alto's shares retreated during the final months of 2012.
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text:
Mike Leake's Complete Game Leads #12 Baseball Past Stanford 5-4
April 5, 2007
TEMPE, Ariz. - Down 4-0 after two innings, things looked dire for Mike Leake and the Devils on Thursday night against Stanford. But Leake shut down the Cardinal from then on, allowing Kiel Roling and the Sun Devil offense to come back and pick up a big 5-4 victory in front of 3,547 fans at Winkles Field-Packard Stadium at Brock Ballpark. With the win, Arizona State improves to 24-10, 5-2 in the Pac-10.
Leake threw a complete game, the first of his young career, striking out eight while allowing only eight hits to up his record to 7-1. Two of the four runs he allowed were unearned.
Stanford scored two runs in the first and two in the second off Leake, collecting five hits in the first two frames. Leake would scatter three hits from that point on. That allowed the ASU offense to work their way back.
The Sun Devils pulled even in the fourth, scoring four times off Stanford starter Jeremy Bleich. Kiel Roling brought the first run home when he singled home Petey Paramore. Things because to unravel for the Cardinal after that, as a throwing error by Bleich allowed Ike Davis to score from second to make it 4-2. Bleich then uncorked two wild pitches, allowing Roling and Tim Smith to score the equalizers.
Roling knocked in the eventual game winner in the seventh, singling home Wallace to give ASU their first lead of the game at 5-4. Leake would strike out five of the final six batters to clinch the win.
Roling was 4-4 with two RBI and Petey Paramore went 2-3 with two doubles.
The Devils and Cardinal continue the three-game series tomorrow night. First pitch is set for 7 p.m. from Winkles Field-Packard Stadium at Brock Ballpark.
Airing on:
- Pac-12 Network
Wed 9/27 | 7:00pm PTLive
Airing on:
- Pac-12 Network
- Pac-12 Arizona
- Pac-12 Bay Area
Thu 9/28 | 3:30pm PTLive
Airing on:
- Pac-12 Network
- Pac-12 Los Angeles
- Pac-12 Oregon
Thu 9/28 | 5:30pm PTLive
Airing on:
- Pac-12 Network
- Pac-12 Mountain
- Pac-12 Washington


text:
Aqib Talib has been suspended four games for a positive drug test that resulted from using Adderall, the Tampa Bay Buccaneers announced Saturday.
"He knows that he made a poor decision that let our team down," Bucs coach Greg Schiano said.
Adderall is commonly used to treat Attention Deficit Disorder, but it can also be used a performance enhancing drug (it's an amphetamine), hence the NFL's mandate to not use the drug.
"Around the beginning of training camp, I made a mistake by taking an Adderall pill without a prescription," Talib said in a statement released by the team. "This is especially regrettable because, for the past several months, with Coach Schiano's help, I've worked very hard to improve myself—professionally and personally—as a player and a man. I am truly sorry to my teammates, coaches and Buccaneers fans, and I'm disappointed in myself. ... I have chosen to be immediately accountable for the situation I put myself in, which is why I will not exercise my appeal rights and will begin serving the suspension immediately."
Talib isn't the first player this season to be suspended for Adderall usage. Browns CB Joe Haden missed his team's first four games for the same reason.
The Buccaneers are scheduled to play at home Sunday against the Kansas City Chiefs. Kickoff is 1 p.m. ET.


text:
Vigils are reportedly being planned around the country for the weekend of Oct. 9-10 to honor and remember the four youth who've recently committed suicide in response to anti-gay bullying and harassment. Those youth are Asher Brown, 13, of Houston; Seth Walsh, 13, of Tehachapi, Calif.; Billy Lucas, 15, of Greensburg, Ind.; and Tyler Clementi of New Jersey.
A conference call is planned for Thursday night, Sept. 30 to coordinate the vigils. We'll have more info as soon as it becomes available.


text:
[Page 26]
|The Board of the Loan Society of Artisans
|[Also known
as the Handworker's Union]
(standing left to right): Simonovitz, Baradovski, F. Levin, Naumovitz, Gomberg;
(sitting left to right): Gulan, Davidovitz, Gafanovitz, Lekach, Kuperman
|Monday a market day in Rokiskis
[Page 31]
|A farm yard in Rokiskis
JewishGen, Inc. makes no representations regarding the accuracy of
the translation. The reader may wish to refer to the original material
for verification.
JewishGen is not responsible for inaccuracies or omissions in the original work and cannot rewrite or edit the text to correct inaccuracies and/or omissions.
Our mission is to produce a translation of the original work and we cannot verify the accuracy of statements or alter facts cited.
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Updated 10 May 2003 by OR


text:
Argentina coach Javier Weber: We played very well, mainly on our serve and in defense. I am happy with the victory since we never give up fighting.Argentina captain Rodrigo Quiroga: It was a hard but good victory, since we knew how to overcome our adversities, starting with the travel itself to Portugal, and we were able to win against such a good team as Portugal.
Portugal coach Juan Diaz: Congratulations to Argentina. Both teams are very similar, but Argentina played better and created many difficulties for us in reception and defense. Later, when the match was finely balanced, our service errors prevented us from gaining any advantage.Portugal player Flavio Cruz: Argentina is a very consistent team. They always put pressure on us and we were unable to reply properly, particularly as we failed on so many serves.


text:
The children from our 'Made for Change' campaign in Bangalore sent us a picture to say 'Thank you' over Christmas! We wanted to share as their school scholarships are funded from sales of our 'Made for Change' shopper bag – you've been buying loads of them which is great news for the kids.
After selling out fast, they are back online now so get one while you can! There are lots of different print combinations to choose from.
A big 'thank you' from the students in Bangalore
The bags are back!


text:
Where will You Be?
What's going on in the Ascension process on Earth right now? How are our lives being affected and how can you work with it?
Here's a thought provoking interview recently with Open by "Conscious Talk Radio" in Seattle...
In 2012, Open (Chris Bourne) gave a wide ranging interview to Ross Pittman of "Conscious Life News" based in California. The subject matter concerned mostly viewpoints about our Ascension and what's really going on right now, shared from both a scientific and spiritual perspective.
Power packed 40 minute podcast
Ian Jones from The UK Spirit Guides network talks with Open (formerly Chris Bourne) about the energy behind the "5 Gateways" documentary. In a wide ranging interview, Open is asked about his views on the evolution in human consciousness taking place, the collapse of the 'matrix', forming sustainable communities and mankind's ultimate destiny...
Here is an insightful podcast interview with Open (formerly Chris Bourne) by "Sein", the online German news site. From his own direct experience, Open offers profound insight into the evolutionary journey. He discusses various topics such as the difference between Awakening and Enlightenment and why there is often so much confusion in the spiritual world. He offers a helpful perspective on distortions and the pitfalls during the spiritual journey.
© copyright Openhand Foundation| privacy policy | terms of use


text:
TORONTO, Ontario — Every day, 250,000 Toronto residents drive past the Ontario Food Terminal, unaware that 5.4 million pounds of fresh produce a day flow through there.
On Sept. 22, the 58-year-old terminal welcomed the public to the first Fresh Fest, organized by the Ontario Produce Marketing Association, Toronto Wholesale Produce Association and the Ontario Food Terminal Board.
An estimated 4,000 people visited the showrooms of major wholesalers, met Ontario growers in the outdoor farmer's market and feasted on fresh salads and Ontario corn on the cob for a $10 ticket.
"It's amazing and long overdue," said John Russell, president of berry importer J.E. Russell Produce Ltd., as locals lined up to buy $1 clamshells of organic Berry Bowl strawberries ($3.99 retail).
"It's good PR for all of us," said Russell. "People don't understand how the terminal fits into the food production distribution chain."
All money raised at Food Fest goes to FoodShare Toronto, a nonprofit community food organization that spent $1 million at the terminal last year for school programs and Good Food boxes.
Tomato King president Vince Carpino gave many their first taste of a warm grilled California chestnut, while his staff handed out slivers of fresh California figs and whole Ontario squash to take home.
At Fresh Taste Produce Ltd., which offered figs, brothers Julian and Christian Sarraino proudly introduced their wares.
"Every person who walks in says they've never seen produce this fresh before," said Christian Sarraino, vice president of procurement.
"They're asking how to choose figs," he said, "and they're blown away by the big bunches of Italian grapes, which we see every day."
Strawberries and raspberries from Driscoll Strawberry Associates Inc. were dipped in a chocolate fountain and baked into tarts at Italian Produce Co. Ltd.
John Sheridan, in sales and purchasing at F.G. Lister & Co. Ltd., handed out pomegranates from Dee Slayman's farm in Bakersfield, Calif.
"Just crack them open!" Sheridan advised anyone who asked what to do with them.
In a covered walkway normally filled with forklifts, Pear Bureau Northwest sampled starkrimson and bartlett pears and urged consumers to "Check the Neck," the group's slogan about choosing fruit.
In the farmers market area, John Denboer surveyed the scene as staff gave away bags of red beets and carrots with his business card tucked inside, and children climbed into the cabs of two tractors he brought in for the day.
"This is one of those moments where you can bring growers and the public closer together," said Denboer, president of the 270-acre Denboer Family Farm in Otterville, two hours southwest of Toronto.
"I'm amazed at the turnout," he said. "We should do this once a year."


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Plan a visit to enjoy these Theme Days at the Wild Zoo Halloween:
*Today: Pumpkin decorating workshop
Get creative! Decorate and take home your own mini-pumpkin for no additional charge.
*Friday: Free train rides
Ride the zoo train as many times as you want today, it's free!
*Saturday: Princess Day
It's every little girl's dream: Meet Cinderella, Snow White, Sleeping Beauty and Tiana on the Australian Adventure Plaza from 1-4 p.m. Bring your camera!
*Sunday: Magic Day
Enjoy amazing Magic Shows at 1:45 and 2:45 p.m. on the Australian Adventure stage
* Wednesday: Animals and pumpkins
Zoo critters get pumpkins treats for Halloween. Will they eat them or play with them? Find out at: 1 p.m., wallaby; 1:30 p.m., bobcat; 2 p.m., goats; 2:30 p.m., otter; 3:30 p.m., dingoes; and 4 p.m., red panda.
The Wild Zoo Halloween is open noon-5 p.m. Oct. 25-28 and 31. Admission is $8 for children, $4 for adults. Zoo Members get $2 off per person every day.
For complete Wild Zoo Halloween details, click on http://kidszoo.org/programs-and-events/wild-zoo-halloween/.You may have heard that the zoo gives out "orangutan-friendly" treats to kids at the Wild Zoo Halloween. What does that mean?
Many products we use in everyday life, such as foods, soaps and cosmetics, contain palm oil. Palm oil is made from trees grown on large plantations in the tropics, including on the islands of Sumatra and Borneo in Indonesia, where orangutans live.
In recent years, unscrupulous individuals have cut and burned huge swaths of rain forests in Indonesia to build new palm oil plantations. Some of these new plantations were built in the middle of national parks, destroying vital rain forest habitat and nearly eradicating wild orangutans, tigers and hundreds of other plant and animal species.
This level of destruction has been swift and unparalleled.
Because palm oil is so integral to the products we use, and because legitimate palm oil plantations provide important jobs for Indonesian people, a movement was born to label products made with "sustainable" palm oil — that is, palm oil grown on plantations that promote best practices and environmental responsibility.
Many companies have joined the Roundtable on Sustainable Palm Oil (RSPO), including many candy manufacturers such as ConAgra Foods, Hershey's, Mars and more. In 2011, the zoo opted to purchase treats which, if they contain palm oil, are made only with sustainable palm oil.
This Halloween, consider buying only treats made with sustainable palm oil for the little goblins that visit your neighborhood. You'll make a statement to manufacturers while doing your part to protect the last remaining wild orangutans.
Download a list of products made with sustainable palm oil at http://www.cmzoo.org/docs/palmOilShoppingGuide.pdf.
Read more about orangutans at http://kidszoo.org/our-animals/indonesian-rain-forest/sumatran-orangutan/.


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Cards set to induct quartet into club Hall of Fame
ST. LOUIS -- The Cardinals opened the doors to their new Hall of Fame and Museum back in April, at which time the organization unveiled the plaques of the first 22 players to be enshrined in the Hall of Fame. On Saturday, those 22 will be joined by another four.
The Cardinals careers of Willie McGee, Jim Edmonds, Marty Marion and Mike Shannon will be celebrated during a 10:30 a.m. CT induction ceremony inside Ballpark Village. While the first wave of inductees earned automatic enshrinement because they had previously been inducted into the National Baseball Hall of Fame as Cardinals or had their number retired by the club, Saturday's group was selected through a voting process that included input from fans and a panel of baseball experts.
The organization assembled a Red Ribbon Panel back in January to select a veteran player inductee, defined as someone who spent at least three seasons with the Cardinals and had been retired from baseball for at least 40 years. Marion, who played 13 seasons in St. Louis, including 11 with the Cardinals, won that vote. He was the National League MVP Award winner in 1944 and a member of three championship clubs.
The Red Ribbon Panel also formed a ballot of modern player candidates, which was then handed over to the fans. Through an online ballot that garnered nearly 80,000 votes, McGee and Edmonds received the most support.
McGee spent 13 of his 18 Major League seasons with the Cardinals and was also an MVP winner (1985) while with the organization. The two-time Gold Glove Award winner ranks ninth in franchise history with 1,661 games played and helped the Cardinals to their ninth championship, in 1982.
Edmonds hit .285 and averaged 30 homers a year during his eight-year tenure with the Cardinals. Beginning in 2000, he won six consecutive Gold Gloves and was a part of six postseason Cardinals teams. He ranks fourth on the franchise list with 241 home runs.
Shannon, a club selection for enshrinement, won two championships during his nine-year career with the Cardinals. He is now in his 43rd season calling games for the Cardinals' radio network.
The three living inductees -- McGee, Edmonds and Shannon -- will all be present at Saturday's induction ceremony, along with Martinna Dill, Marion's daughter. Cardinals and Baseball Hall of Famers Ozzie Smith, Whitey Herzog, Red Schoendienst, Lou Brock, Bob Gibson and Tony La Russa are also expected to be attendance.
Fans interested in coming to the ceremony can purchase an $18 ticket at cardinals.com/hof. The ticket includes admission and a Hall of Fame Induction Day issue of Cardinals Magazine.
The ceremony will be streamed live on cardinals.com, and it also will be shown on FOX Sports Midwest at the conclusion of Sunday's game (1:15 p.m. CT first pitch). KMOX 1120 will air a one-hour, tape-delay broadcast at 4 p.m. CT on Saturday.
Jenifer Langosch is a reporter for MLB.com. Read her blog, By Gosh, It's Langosch, and follow her on Twitter @LangoschMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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High-efficiency components
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Digital control panel
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The quietest and most versatile A/C system on the market, the Webasto FCF Air Conditioning Unit starts with a more balanced system for noise elimination. The compressor has been carefully mounted to greatly reduce unwanted vibration and noises that can transfer into the cabin interrupting your sleep. Unlike competitive systems, FCF stands for quality, including a long-lasting, baked-on enamel finish, a robust blower that can handle multiple vents, and a digital control panel.
• High-efficiency components for superior performance
• Extra low compressor vibration and noise
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Kit Includes
• Seawater Pump
• Bronze Seawater Scoop 3/4" MNPS
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• 3/4" MNPT to 3/4" Hose Barb
• Bronze Seawater Strainer 3/4" NPTF
• Bronze Fitting 3/4" MNPT to 3/4" Hose Barb
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some call me...tim? wrote:Whoa, Hardee's are disappearing? They were as common as Burger Kings when I was still living in the south east. And Blake, I might be mistaken, but I think Carl's Jr. has always been around out here, but they bought out Hardee's, and then Hardee's picked up the "smiley star" motif. Or it might be the other way around. I remember there was one chain that was short lived, but it was really good: "Rax" I believe it was called. It was like a step up from normal fast food, kinda what some of the Arby's restaurants are today. I guess they were before their time though, and didn't last long. Anybody ever eaten at a "Bojangles"? They're another chain I miss from the good ol' days down south.
Rax was straight up the bomb shit. Their roast beef sandwich still makes me crave for it once in a while. They went under long ago (late 80's?), Im not surprised Im not the only one who loved that place.


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The substitute's last-gasp winner broke the visitors' hearts after a superb defensive display had frustrated Antonio Conte's team for much of the match.
The substitute winger, who was booked for diving in the last minute of normal time, redeemed himself when he slotted home from close range after Catania goalkeeper Mariano Andujar flapped at Paul Pogba's searching cross. The goal, coupled with Napoli's surprise defeat to Chievo, mean Antonio Conte's side is now the clear favorite for another Serie A title with 10 games remaining in the season.
The league leaders looked to impose themselves on the game early, but only had an Andrea Barzagli long range effort to show for their endeavors, with the defender's strike flying over the bar.
Mirko Vucinic was rested for the Champions League win over Celtic in midweek, and the break seemed to have done him good as he tested Andujar for the first time, but the goalkeeper turned his shot from distance behind for a corner.
The visitors had decided to try and counter the attacking threat of Conte's side, but they almost took the lead themselves when Alejandro Gomez tried his luck from distance. Gianluigi Buffon was equal to it, though, despite initially spilling his effort.
Long-range efforts then became a theme of the match, with Francesco Lodi and Leonardo Bonucci both firing wide before the home side twice went agonisingly close to breaking the deadlock.
Claudio Marchisio curled a shot wide after good interplay with Vucinic, before the Montenegro striker hit the post after capitalizing on a breakdown in communication in the Catania defense.
The remainder of the half passed with little incident on the field, though Catania coach Rolando Maran was sent to the stands after arguing with the officials.
The second half continued where the first had left off, with Juventus pressing at every opportunity, and Andujar had to be at his best to deny both Bonucci and Paul Pogba in quick succession. Pogba slowly made his way into the match after a quiet start, and he went close again as he volleyed an effort wide from 25 yards.
Vucinic was still the biggest threat for Conte's side, but his finishing wasn't up to its usual standard, highlighted when he could only shoot wide from close range under pressure from the impressive Andujar.
Juventus rang the changes in search of a breakthrough, and one of the substitutes, Alessandro Matri, went close with a header as the game entered its final 10 minutes.
Giaccherini then took center to emerge as the hero, and Fabio Quagriella almost doubled the lead, but Andujar parried well from the Italy striker to keep the scoreline at 1-0.


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I have thrown an Aviar since I started playing, about 20 years ago. Lately I have been playing more and more than I did in the past. I like the Aviar but the more I play the less I like the feel of it in my hand. I think it has to do with the shape of most midrange discs and drivers. The rims are totally different. I won't mention that I like Rocs.
I want to get better at putting and my technique seems to be fine. My plan is to go out and buy 10-15 putters and a portable basket and practice like hell. This would make now a good time to switch to a different putter if I am ever going to do it. The main contender I am considering is the Wizard. I am sure there are tons of people that have played both and decided to switch over for whatever reason from one to the other. Why did you choose the one you did?
Right now I am pretty sure I will choose the Wizard due to the price, feel of the rim, and different softness choices. Hmm maybe I should switch to the Buzz over the Roc.


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Toggle: English / Spanish
Pityriasis rosea is a common type of skin rash seen in young adults.
Pityriasis rosea is believed to be caused by a virus. It occurs most often in the fall and spring.
Although pityriasis rosea may occur in more than one person in a household at a time, it is not thought to spread from one person to another.
Attacks most often last 4 to 8 weeks. Symptoms may disappear by 3 weeks or last as long as 12 weeks.
The rash starts with a single large patch called a herald patch. After several days, more skin rashes will appear on the chest, back, arms, and legs.
The skin rashes:
Your health care provider can usually diagnose pityriasis rosea by the way the rash looks.
Rarely, the following tests are needed:
If symptoms are mild, you may not need treatment.
Gentle bathing, mild lubricants or creams, or mild hydrocortisone creams may be used to soothe irritation.
Antihistamines taken by mouth may be used to reduce itching. You can buy antihistamines at the store without a prescription.
Moderate sun exposure or ultraviolet (UV) light treatment may help make the rash go away more quickly. However, you must be careful to avoid sunburn.
Pityriasis rosea usually goes away within 6 to 12 weeks. It doesn't usually come back.
Call for an appointment with your health care provider if you have symptoms of pityriasis rosea.
Habif TP. Psoriasis and other papulosquamous diseases. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, PA: Elsevier Mosby;2009:chap 8.
Pityriasis rosea. Alvero R, Ferri FF, Fort GG, et al, eds. In: Ferri FF, ed. Ferri's Clinical Advisor 2015. 1st ed. Philadelphia, PA: Elsevier Mosby; 2014:section I.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch)
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Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis
This study has been terminated.
(Closed after complete treatment of 32 patients after 21 months' recruitment.)
National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: December 28, 2010
Last updated: September 16, 2013
Last verified: October 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The primary objective of this early-stage clinical study is to demonstrate an effect of single doses of CK-2017357 on measures of skeletal muscle function and fatigability in patients with generalized myasthenia gravis (MG).
|Myasthenia Gravis
|Drug: Placebo Drug: 250 mg CK-2017357 Drug: 500 mg CK-2017357
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Phase II, Double-Blind, Randomized, Three-Way Crossover, Placebo-Controlled, Pharmacodynamic Study of CK-2017357 in Patients With Generalized Myasthenia Gravis on Standard Therapy
Resource links provided by NLM:
Genetics Home Reference related topics: myasthenia gravis
MedlinePlus related topics: Myasthenia GravisU.S. FDA Resources
Further study details as provided by Cytokinetics:
Primary Outcome Measures:
- To demonstrate an effect of single doses of CK-2017357 on measures of skeletal muscle function and fatigability in patients with generalized MG. [ Time Frame: 1 day ]
In this hypothesis-generating Phase II study, multiple assessments of skeletal muscle function and fatigability will be made without specifying a single primary endpoint, including:
- Quantitative MG score (QMG)
- Pulmonary Function Test (VC in liters)
- Manual Muscle Test (MMT)
Secondary Outcome Measures:
- To evaluate and characterize the relationship, if any, between the doses and plasma concentrations of CK-2017357 and its pharmacodynamic effects (PK/PD relationship) [ Time Frame: 2 days ]
- To evaluate the safety and tolerability of CK-2017357 administered as single oral doses to patients with MG [ Time Frame: 4 weeks ]
- To evaluate the effect of CK-2017357 on investigator and patient determined global functional assessment and the Modified MG Symptom Score [ Time Frame: 2 days ]
|Study Start Date:
|December 2010
|Study Completion Date:
|October 2012
|Primary Completion Date:
|October 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Three-way crossover
2 oral dose levels of CK-2017357 and placebo
Drug: Placebo
Matching placebo in capsules administered as a single oral dose.Drug: 250 mg CK-2017357
250 mg CK-2017357 in capsules administered as a single oral dose.
Other Name: tirasemtivDrug: 500 mg CK-2017357
500 mg CK-2017357 in capsules administered as a single oral dose.
Detailed Description:
This study is a Phase II, double-blind, randomized, three-way crossover, placebo-controlled, PD study of CK-2017357 in patients with generalized MG on standard therapy. 36 to 78 patients will be randomized at approximately 15 study centers to one of six different treatment sequences. Each treatment sequence consists of three dosing periods in which patients receive single oral doses of placebo, 250 mg, and 500 mg of CK-2017357. All six treatment sequences will enroll 6 patients. A wash out period of at least 7 days (to a maximum of 10 days) will be employed between the individual doses for each patient. This study is designed to assess the effects of CK-2017357 on measures of muscle strength, muscle fatigue and pulmonary function utilizing the standardized Quantitative MG (QMG) score and Manual Muscle Test (MMT). The pharmacokinetic (PK) and pharmacodynamic (PD) relationship of CK-2017357 after two single doses will be assessed versus placebo, and the CK-2017357 concentration versus time data obtained in this study may be used to develop a population PK model to estimate intra- and inter-patient variability of PK parameters in patients with MG.
|Ages Eligible for Study:
|18 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Patients who meet the following criteria may be included in the study:
- Ability to comprehend and willing to sign an Informed Consent Form (ICF)
- Ability to understand written and oral English language
- Males and females between 18 and 80 years of age, inclusive
- Patient's signs and symptoms not better explained by another disease process
- Established diagnosis of MG defined as clinical evidence of muscle weakness and positive AChR-binding antibody titer (>0.02 nmol/L)
- Myasthenia Gravis Foundation of America (MGFA) clinical classification II or III
- Stable MG disease for 4 weeks prior to randomization
- Ability to refrain from IVIg treatments during the course of the study
- Ability to refrain from cholinesterase-inhibitors (e.g. pyridostigmine) for 12 hours before each dose
- Ability to perform all elements of the QMG
- Grade of 2 or 3 in two or more of the following muscle groups as measured by QMG: right or left arm flexion, head lift, and right or left leg raise at 45° Note: Patients may re-screen if they fail due to inadequate weakness from taking pyridostigmine within 12 hours of screening
- Body mass index (BMI) of 18.0 to 36.0 kg/m2, inclusive
- Pre-study clinical laboratory findings (including troponin I [TnI] and creatine phosphokinase [CPK]) within the normal range, or if outside of the normal range, deemed not clinically significant by the Investigator
For female patients only: Agreement
- to use a double barrier during sexual intercourse (1 hormonal, plus 1 barrier method, or 2 simultaneous barrier methods) birth control (birth control pills, male condom, female condom, intrauterine device, Norplant, tubal ligation, or other sterilization procedures)
For male patients only: Agreement either
- to use a condom during sexual intercourse with female partners who are of reproductive potential and to have female partners use an additional effective means of contraception (e.g., diaphragm plus spermicide, or oral contraceptives) for the duration of the study and 10 weeks after the end of the study or b. to abstain from sexual intercourse for the duration of the study and 10 weeks after the end of the study
The following criteria exclude potential patients from the study:
- History of chronic degenerative, psychiatric, or neurologic disorder other than MG that can produce weakness or fatigue
- Other major chronic or debilitating illnesses within six months prior to study entry
- Hepatic insufficiency (defined as ALT or AST > 3x ULN, or total bilirubin > 3 mg/dL)
- Renal insufficiency (defined as serum creatinine > 2.5 mg/dL or receiving dialysis)
- Other myasthenic syndromes (e.g. Lambert Eaton syndrome; inherited myasthenic syndrome)
- Female patients who are premenopausal and are: (a) pregnant on the basis of a serum pregnancy test, (b) breast-feeding, or (c) not using an effective method of double barrier (1 hormonal plus 1 barrier method or 2 simultaneous barrier methods) birth control (birth control pills, male condom, female condom, intrauterine device, Norplant, tubal ligation, or other sterilization procedures)
- Receipt of IVIg or plasmapheresis treatment within 6 weeks prior to the first dose of study drug
- Changes to immunosuppressive treatments (i.e., prednisone) within 6 weeks prior to the first dose of study drug
- Rituxan treatment within 3 months prior to study entry
- Participation in any other investigational study drug or device trial in which receipt of an investigational study drug or device occurred within 30 days prior to dosing
- Any prior treatment with CK-2017357
- Recent history of alcoholism or drug abuse, or significant behavioral or psychiatric problems, or other conditions which in the Investigator's opinion may impair ability to adequately comply with the requirements of the study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01268280
Please refer to this study by its ClinicalTrials.gov identifier: NCT01268280
|United States, California
|UCSF - Fresno
|Fresno, California, United States, 93721
|University of California - Irvine
|Orange, California, United States, 92868
|California Pacific Medical Center
|San Francisco, California, United States, 94115
|Stanford University
|Stanford, California, United States, 94305
|United States, Connecticut
|Hospital for Special Care
|New Britain, Connecticut, United States, 06053
|United States, Kansas
|The University of Kansas Medical Center
|Kansas City, Kansas, United States, 26506
|United States, Maryland
|Johns Hopkins
|Baltimore, Maryland, United States, 21205
|United States, Massachusetts
|Neurocare Center for Research
|Newton, Massachusetts, United States, 02459
|United States, North Carolina
|University of North Carolina
|Chapel Hill, North Carolina, United States, 27599
|Duke University
|Durham, North Carolina, United States, 27710
|United States, Pennsylvania
|Drexel University College of Medicine
|Philadelphia, Pennsylvania, United States, 19107
|West Penn Allegheny Health System
|Pittsburg, Pennsylvania, United States, 15212
|United States, Texas
|Baylor College of Medicine
|Houston, Texas, United States, 77030
|United States, Virginia
|University of Virginia Health System
|Charlottesville, Virginia, United States, 22908
Sponsors and Collaborators
National Institute of Neurological Disorders and Stroke (NINDS)
|Study Director:
|Andrew Wolff, MD, FACC
|Cytokinetics, Inc.
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01268280 History of Changes
|Other Study ID Numbers:
1RC3NS070670-01 ( U.S. NIH Grant/Contract )
|Study First Received:
|December 28, 2010
|Last Updated:
|September 16, 2013
Additional relevant MeSH terms:
Muscle Weakness
Myasthenia Gravis
Muscular Diseases
Musculoskeletal Diseases
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Pathologic Processes
Signs and Symptoms
Autoimmune Diseases of the Nervous System
Neuromuscular Junction Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text: Unlike during the football season when I frequent many other teams message boards, I never go to other NBA boards. The Patriots message board is like nothing I've ever seen. They can't be happy winning - they have to have some drama or something to complain about as well. I was just curious if there is a board like that for an NBA club you've seen. From what I have gathered from here the Lakers might be one of them.


text:
Sounding Them Out - ILanguage brain teasers are those that involve the English language. You need to think about and manipulate words and letters.
Given below are five pairs of words. Each pair sounds similar, but have different meanings (they are homonyms). Can you find them?
Lift high - Bring down, destroy
Plant with ears - Labyrinth
Burial/Cremation formalities - Uses a pen and paper and forms legible words
To communicate with God - Carnivore's target
Watery part of milk that separates when milk turns to curds - The route or the course traveled from one place to another
AnswerRaise - Raze
Maize - Maze
Rites - Writes
Pray - Prey
Whey - Way
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this brain teaser, keep track of
which ones you have seen, and even make your own.
Back to Top


text:
NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Tuesday, September 26, 2017
Cathy Benninger, RN, MS, APRN, C-AE
Clinical Assistant Professor
Director, OSU Asthma Center Educational Program
College of Medicine
The Ohio State University
John G Mastronarde, MD
Clinical Professor of Pulmonary, Allergy, Critical Care & Sleep
College of Medicine
The Ohio State University


text:
I believe in the cosmology that the Buddha taught in the Suttas, thus I believe in Brahma, devas, ghosts and hell beings.
It won't stop you meditating, or practicing the Buddha's teachings if you don't believe in them. But I believe at a certain point you have to take the Buddha at his word, and surrender your own views in favour of those of the Buddha, realizing that one is ignorant of the truth, and the Buddha has known and seen. Until one is ready to submit that they are blind and ignorant - one can only progress so far. Rebirth is intricately tied to the teachings. If rebirth does not exist then one need only meditate enough to prevent the grosser manifestations of dukkha, and wait until death comes. In such a view death brings nibbana. This is a wrong view, in the Buddha's teachings. Buddhism doesn't make much sense without rebirth.
That is my view, and it appears to be right to me, but I cannot say anything for sure.


text:
It came on trucks, wrapped in paper.
The newest house being built in Mendocino caused a stir when residents of the historic district saw a prefabricated home was being built yards away from Category I historic buildings.
Members of the Mendocino Historic Review Board and town residents raised the question of whether the project at 45068 Ukiah St. was approved by the MHRB in March 2013 with the knowledge that it would be constructed off-site.
The issue was discussed during the Monday, July 7, meeting of the MHRB.
Ed O'Brien, former MHRB member, said that Mendocino County Planning and Building Services staff let the board down by not explicitly telling it at the time that the planned development was going to be a prefabricated house.
Rick Sacks, owner of The Sign Shop, said the review board's charter to preserve the character of the town means more than just reviewing what a project will look like on the outside, but should be about reviewing more of process of a project.
Who knew?
Bill Kinser, the planner with Planning and Building Services who replaced former staffer Abby Stockwell in February, said there was nothing explicit in county records that would indicate that the house was a prefabricated structure.
Wendy Roberts, board vice chair, said Stockwell had told her after the March 2013 meeting, and not on the official meeting record, that the house was prefabricated. Roberts never imagined it would be constructed in Sacramento first, she said, but it is actually a "stick built" house and not a mobile home or double-wide trailer.
Kelly Grimes, an architect with extensive experience dealing with the MHRB, said the issue brought up a larger question of enforcement by Mendocino County of the board's decisions. He said it was not just the prefabricated house, but also alterations to existing structures, such as vinyl windows when they are all supposed to be wood.
The construction has not gone unaddressed by Mendocino County's code enforcement inspectors. Kinser said the county was on site twice since the main portion of the house arrived, after calls began to come into the Fort Bragg office from concerned neighbors.
When the house arrived, it was sporting aluminum windows, which violates the historic district's guidelines. However, replacement wood windows were already on site for installation, Kinser said.
Roberts said the roof will be framed consistent with the architecture of the town and, when completed, the house will also have the distinctive dormers that are characteristic of Mendocino.
Beth Perrill, board chair, said that when the clipper "The Frolic" went aground near Caspar in 1850, it was carrying a prefabricated house. The wreck initiated early American settlement of Mendocino.
"What goes around, comes around," she said.
All the same, the unconventional manner, for Mendocino, of the house's construction and arrival upset residents.
"It was slap in the face," said resident Katey O'Brien, who felt the project disregarded the core philosophy of the historic district.