text:
So close. Then so far. And so tough.
"That's baseball," said manager Bud Black Saturday night after Evan Longoria's two-out, two-run walk-off homer against closer Huston Street gave the Tampa Bay Rays an 8-7 victory over the Padres at Tropicana Field.
It was a bitter loss for the Padres, who battled back from a 6-2 deficit to take a 7-6 lead with a five-run seventh that included the first grand slam homer of Jesus Guzman's career and a later go-ahead, bases-loaded walk drawn by Carlos Quentin.
Afterwards, Guzman appeared almost in tears as he discussed his slam.
"We lost the game, we didn't win," he said. "It was an exciting moment for me, but we lost."
The Padres lost when Longoria launched a hanging slider from Street far beyond the fence in left center.
Seven pitches earlier, the Padres came within an inch of walking away with the 7-6 win.
Street had two outs and a 2-and-2 count on Ben Zobrist, who had been badly fooled by several sliders from the Padres closer. Street threw a fastball that Zobrist barely tipped – the ball coming straight back at Padres catcher Nick Hundley.
Game over if the ball hits the sweet spot in Hundley's glove. But the foul caught the palm of the glove, hung there and fell to the ground for a foul that kept the game alive. Another foul and two balls later found Zobrist at first with a walk and Longoria at the plate.
The rest is recorded history. Longoria's drive was measured at 418 feet – marking the fifth time in his career that he hit a walk-off homer. The homer was the third baseman's ninth since April 15.
"If Zobrist's foul hits me an inch more into the glove (to his right), it's over," said Hundley.
"Can't walk that guy," Street said of Zobrist. "I'm frustrated about that walk as much as I am about leaving the pitcher over the middle of the plate. It's a game I wanted to win, that we all wanted to win because of the way we came back. It's just frustrating for me to make that pitch, but you gotta move on."
As for the slider that Longoria hit, Hundley said it was the only mistake Street made in the ninth.
"He hung a slider to Longoria, that's the fate of a closer," Padres manager Bud Black said of Street's first blown save of the season.
Until that instant, it appeared the Padres had pulled the game out with their five-run seventh that overcame a disastrous major league debut by Padres starter Burch Smith, who allowed six runs without retiring a Rays hitter in the second inning.
The Padres trailed 6-2 entering the top of the seventh and Rays starter Jeremy Hellickson had retired 16 straight when he issued the first of two walks Quentin would draw in the inning.
A one-out single by Mark Kotsay and a two-out infield single by Alexi Amarista, who made a diving catch on the warning track in center in the sixth to save at least one run, set the stage for Guzman.
Guzman, who was 2-for-13 as a pinch-hitter this season, sent a full-count offering from Hellickson into the seats down the line in left for the Padres first pinch-hit grand slam since Josh Barfield connected against the Giants on Aug. 17, 2006.
The Padres first road pinch-hit grand slam since Melvin Nieves connected at Shea Stadium in 1995 tied the score at 6-6.
Jamey Wright replaced Hellickson and watched as second baseman Zobrist mishandled Everth Cabrera's grounder for an error. Wright then hit Will Venable with a pitch before issuing back-to-back walks to Chase Headley and Quentin to force in the go-ahead run.
Headley hit a two-run homer in the first to give Smith a 2-0 lead before he threw his first major league pitch.
And the 23-year-old right-hander looked sharp in the first, striking out the first two major league hitters he faced – Matt Joyce and Kelly Johnson – in a perfect inning as his fastball ranged from 94-98 mph.
But his major league debut quickly went from sweet to sour to distasteful. Smith never recorded an out in the second in what turned out to be the second-shortest debut ever by a Padres starting pitcher.
In 1974, Dan Spillner gave up four runs before being pulled from his major league debut after two-thirds of an inning.
Smith's debut lasted one inning plus seven hitters as he gave up six runs on five hits and two walks. Smith saw his two-run advantage wiped out two hitters into his disastrous second inning on a 420-foot homer to right by former Dodgers first baseman James Loney.
That was only the start of Smith's problems. Known for his control as well as his fastball, Smith walked two of the first three hitters he faced in the second. He then gave up four straight hits before being pulled by Black.
"Smith was a tale of two different innings," said Black. "He was sharp in the first. That's a good arm. His pitches will play well in the major leagues. But in the second, it looked like he couldn't find the plate and when he did it was in the middle of it."
"Disappointing," said Smith. "I was focusing on making pitches. I wanted to get ahead. That's my game. I didn't in the second. I gotta come out next time and do better."
Smith's best chance at escaping the inning came on the third hit of the streak, a line drive by Yunel Escobar that skipped off the top of the leaping Headley's glove. Had the third baseman caught the liner, the Padres would have had a double play.
Tyson Ross picked up for Smith and, after giving up a sacrifice fly, held the Rays scoreless on three hits and a walk over four innings.


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Nearly 70 prospects attended Auburn basketball coach Tony Barbee's Elite Camp Friday including Milton three-star forward Shaquille Johnson and Southwest Dekalb four-star guard Jordan Price.
Johnson and Price, both Auburn commitments from the state of Georgia, participated in the one-day camp that featured drills, scrimmage games and a guest speaker, former Auburn and NBA star Charles Barkley.
Barkley spoke to the large group at the beginning of the camp.
"It was cool seeing Barkley there and listening to what he had to say," said Johnson, 6-foot-5, 195 pounds. "He talked to the group and then I got to talk to him one-on-one. He told me to stay focused in school, don't worry about anything else, and to keep my head on straight. That was real cool talking to him."
Price, 6-foot-5, 215 pounds, said Barkley had his attention from the introduction.
"It is always good to listen to an NBA legend and soak in whatever he has to say," said Price. "And for it to be Charles Barkley, I tried to soak in everything. I really liked hearing what he had to say."
Following Barkley's speech, Johnson, Price and the others went through drills before teaming up for scrimmage games.
"Me and Shaq ended up on the same team and did pretty good," said Price. "We were just trying to get a feel for playing together because we are going to be playing together at Auburn."
And possibly rooming together.
"We've known each other since the eighth grade so we are good friends," said Johnson. "We are looking forward to going to Auburn together, and we've been talking about being roommates when we get there."
Neither have any doubts they will honor their commitment to Auburn.
"I'm staying with Auburn," said Johnson. "The camp just made me feel better about my decision. Every time I go to Auburn, I feel more and more at home.
"I have a great relationship with Coach (Milt) Wagner. I really like him. I really like Coach (Tony) Barbee. I like all of the coaches. I feel like they have the program on the right path and I want to be a part of it."
Price said he is trying to help recruit more top prospects to Auburn. He and Johnson both did Friday.
"At the camp, Shaq and I talked to a lot of guys," said Price. "There were a lot of prospects there that looked good. We were trying to recruit and make Auburn better.
"No question that I am solid with my decision. I feel good about Auburn."
Price and Johnson both are currently at The LeBron James Skills Academy in Akron, Ohio. The Academy claims to feature the top 80 high school players in the country.
"It's going good," Price said Wednesday from Ohio. "Shaq and I are on the same team called 'Syracuse'. We have just done a lot of drills so far, but (Thursday) morning we will practice with our team and then start playing games in the afternoon."
Rivals.com ranks Price the No. 11 shooting guard and No. 70 overall recruit in the 2012 class.

subset: commoncrawl


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CROSS Keys aim to finish this season's British and Irish Cup group stages with a bang as they cling on to their faint hopes of making the quarter-finals, writes Iwan Gabe Davies.
Greg Wood's men travel to Birmingham to face English Championship strugglers Moseley on Saturday knowing that even a bonus point victory may not be enough to see them through to the last eight.
Five points well-earned in a 30-10 victory over Ealing on the weekend has kept Keys in the hunt, but other results will also need to go their way should they get another bonus point win.
The Pandy Park outfit are on 14 points after their five tournament games so far as they target one of two places allocated for the best runners-up out of the six groups.
With competition champions Leinster A the runaway winners of Pool 1, the Gwent side could lose out to teams like Munster, London Welsh and Pontypridd who also have so much to play for on the final weekend.
Woods was delighted with the triumph over bottom Championship side Ealing and outlined his side haven't given up the ghost yet.
"We played pretty well against Ealing who are a very organised and determined team and we were delighted to get that fourth try," he said.
"I thought our back row of Phil Sargent (the former Bedwas captain making his Keys debut on the blindside), Scott Matthews and Adam Powell were outstanding as was Reuben Tucker when he came on as well.
"Ryan Lee (another new signing from Newbridge who is a Keys old boy) is a quality back and Dorian Jones controlled the game well at outside-half again.
"We did Gwent proud on Saturday and we are targeting 19 points when we play Moseley on the weekend.
"We came through unscathed with no injuries and the aim now is to finish the group stages on a high in Birmingham on Saturday."
Keys won a hard fought 20-16 victory over the famous Midlands club when the two met back in October.
Moseley have only won one game in the tournament this season, beating Ealing 33-10 at home, but they pushed Leinster A hard both home and away, going down just 24-22 and 23-13 respectively.
But with their Championship status far from secure, Moseley may not go into the weekend's clash against the 2012 British and Irish Cup finalists fully loaded with their first choice players.


text:
Discover the fun way to grow your child's maths skills!
Mathseeds teaches kids aged 3-9 the core maths and problem solving skills needed to be successful at school with fun, highly interactive and rewarding lessons.
Mathseeds combines highly structured lessons with fun motivational elements that keep children engaged and keen to learn.
Your kids can start learning with Mathseeds anytime and anywhere there is a computer or tablet – just click the 'free trial' button to get started!


text:
IE Brown Executive MBA
IE Business School and Brown University have forged a unique alliance to offer a joint Executive MBA degree that goes beyond the boundaries of traditional business education. Anchored in the values and strengths of both institutions, the IE Brown Executive MBA integrates innovative management skills with the human sciences and practical business studies. The 15-month curriculum is designed for executives who seek to inspire those around them and disrupt the future of business.
These reflective leaders will explore the complex context that shapes the world around us via a program that employs both face-to-face and interactive online learning, allowing participants to grow their network, engage in new experience, and embed their newly acquired knowledge in their day-to-day professions.
Global Recognition
IE Business School is considered one of the world's leading business schools by international media like the Financial Times, The Economist, Wall Street Journal or América Economía.
Learn more about IE's Global Business Recognition »


text:
Victoria's Secret Very Voluptuous Lip Plumper
Victoria's Secret Very Voluptuous Lip Plumper Reviews
My favorite plumperThe only reason I didn't give this plumper at 10 is because I use it so quickly I don't feel like I get my moneys worth. However, it really works. I have pretty full lips but when I apply this they look bigger. With all lip plumpers you will feel the tingling, but it does not hurt or last really long. I mostly just wear it alone but it does look pretty if you put a thin layer of lipstick or li...read morener with it as well. $26 is quite a lot to pay for a lip plumper but if you will use it it's great! A little tip....I like the regular lip plumper they have that's only $18 because the baby pink color is so gorgeous!!! That's my favorite for sure. — 4 years, 11 months agoLamexicana1 | 221 reviews
This review is: Helpful | Not helpful | Inappropriate | 1 of 1 people said helpful
VS Lip PlumperEven though I have full lips and don't need a lip plumper, I enjoy using the product. It's got the perfect amount of color. The downside is that it's tacky on your lips and some people may not like that. I'm used to it, so it doesn't bother me. It's over-priced, but most products of this nature are. If you're not sure about trying this one, see what types of lip plumping glosses are available at y...read moreour local Target or pharmacy, as they might have something more along the lines of what you're looking for. — 5 years, 7 months agoMissPoison | 249 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 2 people said helpful
Hold On, Don't Swipe That Plastic!Before you go out and spend almost thirty dollars on this stick of lipgloss, hear me out. While some lip plumpers out there deliver a tactic to create an illusion of full lips or even actually expand because of a collagen reaction, this is just a plain Jane standing next to them. This didn't fulfill any expectations nor does it even live up to its own claims and for twenty-six bucks for a clear ...read morelipgloss, you're better off purchasing a Dior for even a couple bucks less. This is completely unbelievable that this product even lasted so long on Victoria's Secret's market for cosmetics because while you can feel a tingle on your lips, you may as well add some spice powder your lip gloss and call it even. It's a chunky silver tube of false hopes for those in dire need of glamourizing their lips but I'll tell you these won't even come near giving you Tyra's or Selita's gorgeous pouts. — 9 years, 4 months agoVLA | 336 reviews
This review is: Helpful | Not helpful | Inappropriate | 8 of 8 people said helpful
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My Reasons for Reporting This


text:
Upgrading a Wastewater SCADA System
The City of Yuma installed a SCADA system to control and monitor its water and wastewater distribution system remotely. But as the city expanded, the existing SCADA system lacked the needed support, performance and diagnostic capabilities.
By Bob Moreno, Electronics Technician for the City of Yuma
Motor Control
The city of Yuma is tucked in the Arizona desert near the state's borders with Mexico and California. It is the nation's third-fastest-growing area, and over the past decade, Yuma's population has grown more than 50%, with no signs of slowing down.
Yuma's population doubles in winter as retirees and visitors flock to the warm climate. Explosive growth has placed tremendous demands on the city's ability to reliably and efficiently collect up to eight million gallons of sewage per day through its wastewater collection system.
In 1985, Yuma installed a proprietary SCADA system to control and monitor its water and wastewater distribution system remotely. But as the city expanded, it became clear that the existing SCADA system lacked the needed support, performance and diagnostic capabilities.
A typical remote water pump station site with an MCC, a control panel and a generator all installed outdoors.
Because the SCADA system lacked the functionality to monitor individual lift station pumps in outlying areas remotely, operators were not alerted to pump malfunctions. They would instead often learn about pump problems from residents' phone calls or when they were found during scheduled pump station visits.
Upgrades were difficult and costly because the system was proprietary. Those of us working on the systems were often forced to contract outside support services for routine maintenance and repairs at a cost of up to $5,000 or more per visit. As the system aged, these visits were becoming more frequent, usually once a month for each of more than 20 sites. Quick access to replacement parts was also an issue, with spares often taking more than a month to arrive.
The outdated SCADA system also made it difficult for the City of Yuma to meet increasingly stringent environmental regulations, and violations could have resulted in hefty fines.
Changes Needed
Our consulting engineers, our internal project management and our operational staff all knew that we needed a new SCADA system that was easy to use, scalable, reliable and more cost-effective than the existing one. We wanted a system that plant operators could configure and monitor over a network. Finally, the system had to be supportable with our own internal resources so we wouldn't have to rely on outside contractors.
The new system needed to accommodate additional pumping stations to meet Yuma's expected residential and industrial growth. Reliable monitoring capabilities were critical to maintain regulatory compliance, and we needed to keep operational and support costs low to stay within a tight municipal budget.
A key feature needed for the new system was the ability to help operators avoid delays in wastewater service. We also needed a responsive and dependable control system vendor that could supply spare parts quickly and troubleshoot system problems efficiently.
We worked with Yuma-based OneSource Distributors and teamed with Rockwell Automation to develop a control system to meet our needs. Critical to success was developing a SCADA system that remotely monitored all outlying stations from the central control room at the main treatment plant.
"Some of our pumping and lift stations are more than 11 miles from the main plant," says Arlen Ritter, a senior operator with the City of Yuma. "We needed a networked system so we'd know exactly where to send maintenance personnel to investigate or repair a problem. We also wanted remote alerts to eliminate the need for wastewater personnel monitoring pump stations 24 hours a day."
We now have 26 remote sites, each equipped with an Allen-Bradley Intellicenter MCC (www.rockwellautomation.com). MCC motor control includes E3 Plus solid-state relays networked to a local PLC via DeviceNet. Of the 26 remote sites, five are main wastewater pumping stations, and each of these has an SLC 500 PLC acting as the remote terminal unit (RTU). The 21 remote water pump stations each have a SLC 5/03 RTU.
The City of Yuma's main wastewater pumping station motors are controlled and monitored by multi-section MCCs. The motor control circuit solid state relays are linked to a local RTU PLC via DeviceNet.
In both cases, the RTU PLC talks to the solid-state motor control relays via DeviceNet. This high-speed digital link allows us to monitor pump motor amperage, elapsed pump motor runtimes and several pump motor fault conditions.
At the main control room, we installed an RSView Human Machine Interface (HMI) to remotely control and monitor the remote sites. We have RSView running on a two screens, one 21" and the other 42".
Communications between the main control room and each of the 26 remote sites is via a licensed radio frequency. Each RTU is linked to its remote radio via an RS-232 link, and the RSView HMI stations are also linked to the home base radio via RS-232.
Money Saved, Improvements Made
We installed the new SCADA system for about $245,000, half the installed cost of the old system. The new SCADA system monitors and reports individual pump status and other critical operational parameters to one central location. This saves us up to $100,000 a year in labor because we don't have to routinely send plant personnel to each remote site.
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text:
By WAYNE MA
BEIJING -- China on Monday said consumers will need to bear some of the costs of tighter fuel standards, opening the door to higher prices at fuel pumps as the nation balances growing public concern over the environment with worries about inflation.
The announcement comes after a number of episodes of severe air pollution in recent months in Beijing and several other places. The Beijing government also on Monday mapped out plans to combat air pollution including limiting the number of motor vehicles in the city to six million by 2017. In January this year, the official Xinhua news agency said Beijing had around 5.18 million vehicles.
The National Development and Reform Commission, China's top economic planning agency, said higher costs to improve nationwide fuel quality will be borne by both the refining industry and its consumers. It didn't elaborate.
"Currently, the situation of the atmospheric environment in China is grim," the NDRC said in a statement on its website.
Tiny particulate matter in the air has "harmed the health of the population and has had an impact on society and harmonious stability," it said.
Chinese refiners have resisted costly upgrades to raise fuel standards due to Beijing's strict control over fuel prices, which has made it difficult to pass on higher costs to consumers. However, the Chinese government unveiled major reforms to its fuel-pricing system this year, which has improved bottom lines and made it easier for other overhauls.
China, which has lagged Western countries in fuel standards, plans to improve fuel quality over time using a similar roadmap followed by the US and Europe. For example, one target is to limit the concentration of sulfur in gasoline to 50 parts per million (ppm) from 150 ppm before the end of this year. The NDRC said China's two largest refining companies pegged the cost of doing that at 290 yuan a metric ton, or about 13 US cents/gal. It wasn't known how much of that cost would be passed on to consumers. The average price of gasoline in China is around $4.21/gal, according to consultancy ICIS C1 Energy.
The NDRC said that because of rapid growth in car ownership in China, vehicle emissions now account for between 20% and 30% of the country's overall emissions of PM 2.5-tiny particulate matter harmful to human health.
Meanwhile, the NDRC said it wouldn't raise fuel prices immediately but allow for a gradual transition over the next few years, which will also be determined by local governments. It also said it would temporarily subsidize grain farmers and the forestry, fishery and transportation sectors to ease the impact on consumers. Dow Jones Newswires


text:
A Trial of Toric Versus Non-toric Intraocular Lenses in Phacoemulsification Cataract Surgery
Recruitment status was: Not yet recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is a randomised controlled trial that formally compares intra-ocular lenses, which can be used in cataract surgery, one of which is the standard 'monofocal' lens, and the other is the newer toric lens which can correct astgimatism.
The null hypothesis is that both intra-ocular lenses give the same visual outcome in cataract surgery. The alternative hypothesis is that the toric lens, provides a better unaided (without glasses) vision, by correcting the participant's astigmatism.
It has been decided to conduct a randomised controlled trial of the two lenses, as although the toric lenses are endorsed by many case series (which show a reduction in astigmatism), they have not been formally compared to the standard lens. An RCT will enable the formal comparison.
It is expected that this trial will take approximately a year to conduct: six months of recruitment and six months of follow-up. A further six months will be required to analyse the data and prepare a manuscript for publication.
The investigators do not plan to conduct an interim analysis or report as this is a short-trial (six months follow-up) using two alternative lens that are CE marked and already widely used.
Participants who have both cataract and astigmatism will be identified from the GP/optometrist referral letter. They will be seen in specially designated clinics for this research study, which will run alongside the routine cataract 'one' stop clinics at St Richard's Hospital and Worthing Hospital. This will allow for those patients who wish to be part of the study to have all the necessary examination done in one visit and for those who decline participation to be seen in the regular cataract clinic. Potential participants will be sent the research trial information (appendix A) with their appointment letter.
After introducing himself the researcher (who is also a senior cataract surgeon at Western Sussex Hospital Trust), will check if potential participants have had the opportunity to read the trial information that they were sent, or give participants a further copy as required. The key points of the trial will be re-iterated by the researcher and they will be invited to ask any questions about the trialThe researcher will check that the potential participant has read and understood the participant information leaflet. They will answer any questions that the potential participant has and will then take signed consent from those willing to participate.
Only one eye (the 'trial eye') from each patient will be used in the trial. In patients with bilateral cataract, one eye will be selected as the trial eye. This will be the eye that the participant prefers, after consultation with the researcher or surgeon, to have operated first. The participant will be allocated a unique study reference number.
Patients who decline to take part in the trial will be offered cataract surgery as per usual WSHT/NHS procedure.
|Cataract Astigmatism
|Device: Phacoemulsfication cataract surgery and intra-ocular lens implant
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
- Unaided LogMAR visual acuity at 2 months post-operatively
- Unaided LogMAR visual acuity at 2 weeks and 6 months post-operatively
- Corrected visual acuity at 2 months and 6 months post-operatively
- Residual spherical and cylindrical prescriptions at 2 weeks, 2 months and 6 months post-operatively
- Patients quality of life questionnaire to assess subjective vision, glare at day/night, subjective colour perception, other symptoms.
|Estimated Enrollment:
|Study Start Date:
|January 2013
|Estimated Study Completion Date:
|January 2014
|Estimated Primary Completion Date:
|January 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Toric intraocular lens
TFlex Lens (623T)
|Device: Phacoemulsfication cataract surgery and intra-ocular lens implant
Placebo Comparator: Monofocal intraocular lens
Superflex Aspheric Lens (920H)/Cflex Aspheric Lens (970C)
|Device: Phacoemulsfication cataract surgery and intra-ocular lens implant
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Symptomatic cataract for which the patient desires surgery
- Corneal astigmatism of greater than or equal to 2 dioptres
- No significant ophthalmic comorbidity
Exclusion criteria
- <18 years of age
- Significant ophthalmic co-morbidity
- Pregnant
- Medically unfit for cataract surgery
- Not competent to give consent
Please refer to this study by its ClinicalTrials.gov identifier: NCT01712503
|Contact: Masoud Teimory
|Contact: Saul Rajak
|United Kingdom
|Western Sussex Hospital Trust
|Not yet recruiting
|Worthing and Chichester, West Sussex, United Kingdom
|Contact: Masoud Teimory email@example.com
|Contact: Saul Rajak email@example.com
|Principal Investigator: Masoud Teimory
|Sub-Investigator: Pari Shah
|Responsible Party:
|Mr Masoud Teimory, Consultant ophthalmologist and principle investigator, Western Sussex Hospitals NHS Trust
|ClinicalTrials.gov Identifier:
|NCT01712503 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 19, 2012
|Last Updated:
|October 22, 2012
Keywords provided by Mr Masoud Teimory, Western Sussex Hospitals NHS Trust:
Intraocular lens
Additional relevant MeSH terms:
Lens Diseases
Eye Diseases
Refractive Errors
ClinicalTrials.gov processed this record on September 21, 2017


text:
'uu'Language brain teasers are those that involve the English language. You need to think about and manipulate words and letters.
There are six words in the English language which have the letter combination of "UU". One of the words is 'Vacuum', can you name the other five?
AnswerMuumuu, Continuum, Duumvirate, Duumvir, Residuum, Vacuum
Muumuu - A long loose dress that hangs free from the shoulders
Continuum - A continuous extent, succession, or whole, no part of which can be distinguished from neighboring parts except by arbitrary division
Duumvirate - A regime or partnership of two persons
Duumvir - A member of a duumvirate
Residuum - Something remaining after removal of a part; a residue
Vacuum - A state of being sealed off from external
or environmental influences; isolation
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text:
July 19, 2013 Approval Letter - Anti-B (Murine Monoclonal)
Attention: Ms. Marcia Palma
c/o NAMSA
4050 Olson Memorial Highway, Suite 450
Minneapolis, MN 55422
Dear Ms. Palma:
We have approved your biologics license applications for the following biological products effective this date:
STN Name of Biological Products
Blood Grouping Reagent, Anti-B (Murine Monoclonal)(For Further Manufacturing Use)
Blood Grouping Reagent, Anti-D (Human Monoclonal) (IgM) (For Further Manufacturing Use)
Blood Grouping Reagent, Anti-E (Human Monoclonal)(For Further Manufacturing Use)
You are hereby authorized to introduce or deliver for introduction into interstate commerce, the biological products listed above under your existing Department of Health and Human Services U.S. License No. 1744. The Blood Grouping Reagents (For Further Manufacturing Use) listed above are indicated for use in the manufacture of Blood Grouping Reagents, Anti-B, Anti-D and Anti-E by Diagnostic Grifols S.A. (Spain) U.S. License No. 1887, to produce in vitro product Blood Grouping Reagents (BGR) under a shared manufacturing arrangement.
Under this authorization, you are approved to manufacture the products listed above at your facility in Loos, France. You must label your products with the proper names that we have approved, and market them as approved in your license applications.
We did not refer your application to the Blood Products Advisory Committee because our review of information submitted in your BLA did not raise concerns or controversial issues which would have benefited from an advisory committee discussion.
The dating period for the products listed above shall be 24 months from the date of manufacture when stored at 2-8 ºC. The date of manufacture shall be defined as the date of the final ------------(b)(4)---- prior to the filling operation.
You currently are not required to submit samples of future lots of the products listed above to the Center for Biologics Evaluation and Research (CBER) for release by the Director, CBER, under 21 CFR 610.2. We will continue to monitor compliance with 21 CFR 610.1 requiring completion of tests for conformity with standards applicable to each product prior to release of each lot.
Two draft copies of the proposed introductory promotional labeling may be voluntarily submitted for advisory comment with a Form FDA 2253 to the Center for Biologics Evaluation and Research, Advertising and Promotional Labeling Branch, HFM-602, 1401 Rockville Pike, Rockville, MD 20852-1448.
You must submit adverse experience reports in accordance with the Medical Device Reporting requirements for medical devices (21 CFR 803) as required by 21 CFR 600.80(k)(2). Since your product is characterized as a device as well as a biological, submit these reports to the MedWatch System using MedWatch Reporting Form 3500A. Required reports should be submitted to the Food and Drug Administration, Center for Devices and Radiological Health, Medical Device Reporting, P.O. Box 3002, Rockville, Maryland 20847-3002.
We acknowledge your written commitment as described in your letter of April 8, 2013, as outlined below:
Postmarketing Studies not subject to reporting requirements of 21 CFR 601.70.
- DIAGAST commits to perform a revalidation of the ---(b)(4)--- method per --(b)(4)-- for ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------(b)(4)--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------. DIAGAST will submit the results to FDA as a Postmarketing Study Commitment – Final Study Report by September 5, 2013.
We request that you submit information concerning nonclinical and chemistry, manufacturing, and control postmarketing commitments and final reports to your BLAs, STN BL 125435/0, 125442/0, and 125443/0.
Please use the following designators to label prominently all submissions, including supplements, relating to these postmarketing study commitments as appropriate:
- Postmarketing Study Correspondence
- Postmarketing Study Commitment – Final Study Report
- Supplement Contains Postmarketing Study Commitment – Final Study Report
For each postmarketing commitment not subject to the reporting requirements of 21 CFR 601.70, you may report the status to FDA as a "PMC Submission – Status Update." The status report for each commitment should include:
- The original schedule for the commitment, and
- The status of the commitment (i.e., pending, ongoing, delayed, terminated, or submitted).
When you have fulfilled your commitment, submit your final report as PMC Submission – Final Study Report or Supplement Contains Postmarketing Study Commitment – Final Study Report.
Sincerely yours,
Jay S. Epstein, MD
Office of Blood Research and Review
Center for Biologics
Evaluation and Research


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Bank robbery suspect faces up to 55 years in prison
January 7, 2013
A 26-year-old transient, who reportedly stole more than $100,000 from Bank of America by threatening employees with a fake explosive device taped to his chest, faces up to 55 years in prison if convicted of all counts.
Jarell Ryan Williams appeared Monday in East Fork Justice Court to hear charges against him which include robbery with use of a deadly weapon, and making threats or conveying false information concerning acts of terrorism, weapons of mass destruction, legal agent or toxin.
He is being held in Douglas County Jail on $300,000 bail.
According to court documents, Williams is accused of threatening to use a handgun or detonate two bombs to extort $260,000 from the Bank of America branch at Topsy Lane on Jan. 4 shortly after noon.
He is accused of taking more than $100,000 from the bank but a specific amount has not been disclosed.
The money was recovered and the explosive device Williams had duct-taped to his chest was a hoax, according to reports.
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There were no injuries.
According to reports, he told employees he had a handgun, 10 pounds of explosives and would blow up the bank if he wasn't given $260,000. He demanded to be taken to the vault.
Court documents indicate he was wearing a fake improvised explosive device taped to his chest complete with wiring and a wrist switch.
"Why am I being charged with use of a deadly weapon if I didn't actually have any weapons on me?" Williams asked East Fork Justice Tom Perkins on Monday.
Perkins advised Williams that anything he said could be held against him, and said it was up to the state to prove the charges.
He told Williams to discuss the matter with his court-appointed attorney, Kris Brown.
Williams reportedly was wearing all black, and ran out of the bank to a church parking lot where he got into a white two-door sedan and drove away.
Witnesses who heard the call on the police scanner saw the suspect allegedly pull into a private driveway on Highway 395 north of Johnson Lane where he was taken into custody.
According to reports, Williams' prior contact with law enforcement involved illegal door-to-door sales for which he received a warning.
Williams said Monday he had no money, was unemployed and lived in Gardnerville with his girlfriend.
District Attorney Mark Jackson said if convicted, the suspect would face up to 15 years in prison on the robbery charge plus a 20-year consecutive enhancement on the weapons charge, and up to 20 years on the threats charge.
Williams' next court appearance is Jan. 16.


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Please note that not all resources contained on the BIOGRAPHIES PROJECT INDEX PAGE have been abstracted and uploaded. This page is a "place holder" for abstracted biographies from "Who's Who in the State of Washington" (1939).
The BIOGRAPHIES PROJECT is a "work in progress", and here's how YOU can help! If you know a "biographical resource" - a regional or community history or a "Who's Who" publication that contains biographical sketches of Snohomish County persons, DO email Marge Reid with the name of the resource, an estimate of how many sketches it contains and where a copy can be found. Of course, if YOU are willing to do the abstracting for that resource, so much the better!


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Origin clout a blow to Melbourne
RUGBY league's commissioners were appointed principally because of their independence and business savvy, but their recent decisions demonstrate they are simply politicians and as beholden to their constituencies as the men they replaced.
Tuesday's announcement that Sydney and Brisbane will continue to host two state of origin games in alternate years for the next five years, except for a lone match at a neutral venue in 2015, reeks of fealty to the state bodies who appointed them, especially Queensland.
The decision will particularly please former Queensland treasurer Terry Mackenroth, one of the four men who chose the eight commissioners.
Mackenroth, nicknamed ''Minister for the Broncos'' when in Parliament and now a board member of the Queensland Rugby League, lobbied hard to ensure half the ARLC, including chairman John Grant, either lived in the northern state or supported the Maroons.
When reports circulated that the Victorian government was willing to pay $2.5 million a game to host an annual origin match in Melbourne for the next six years, the Queensland government was most defiant about not paying to host an event which it had always got for free.
Victorian Major Events, the government-owned company which pitches for imported entertainment, later revised the offer for a game in Melbourne in each of the next two years, meaning Brisbane would have been forced to sacrifice a game to Melbourne in 2013, as Sydney did this year.
In fact, every origin game played in Melbourne bar one in 2009 has been sacrificed by Sydney.
Now, as a result of Tuesday's ARLC decision, the Queensland government-owned Suncorp Stadium won't lose a game over a seven-year period, except one, probably to the MCG in 2015.
The Maroons haven't had a total victory because the commission has ruled Sydney and Brisbane must swap the traditional order of rotation in 2013.
Instead of Brisbane hosting two games next year, Sydney will. Brisbane will stage two games in 2014.
There would be two reasons behind this switch: the Sydney based members of the ARLC must be anxious to stop Queensland winning an eighth consecutive origin series; and NSW Premier Barry O'Farrell probably paid for the opportunity.
Rather than coach Laurie Daley and his Blues travelling twice to Brisbane next year, NSW has a chance of stopping the Maroon rout at the privately owned Homebush stadium, where it has a 68 per cent win record.
Given that O'Farrell, a passionate Blues supporter, was desperate to retain matches in NSW, while Queensland said it would not pay for games, we're entitled to wonder how both states ended with seven games each over the next five years.
Victorian Major Events' past payment for origin games included $400,000 to employ rugby league development officers in Victoria.
Apart from growing the number of players, origin also boosted ratings. More Melburnians watched the Storm win the NRL grand final than Sydneysiders watched the Swans win the AFL premiership, despite the Swans being in the NSW capital 16 years longer.
If the Storm slip down the ladder the next three years, rugby league will lose momentum in Victoria.
The only positive in Melbourne hosting the 2015 game is that no international rugby union teams visit the city that year.
The ARLC has also demonstrated its Queensland bias with the State Cup. Channel Nine will televise every Queensland Cup game live throughout the season, while the NSW Cup must take its chances with Fox Sports.
An ARLC press release indicated Fox Sports will televise three games a week across the Toyota Cup Under-20 competition, the NSW Cup and the elite schoolboys competition in 2013. Given that Toyota Cup games are curtain-raisers to the televised NRL competition and the NSW Cup is scheduled for different days, it's a reasonable assumption Fox Sports would send its cameras to the Toyota Cup.
The only guaranteed NSW Cup game on free-to-air TV is the last one, played on NRL grand final day.
In fact, Grant has indicated he would like to see a play-off between the victors of the NSW and Queensland state cups, suggesting the NSWRL could lose its grand final to free-to-air TV, as well.
Despite its business background, the ARLC seems content to endorse the anti-competitive saying, ''two's company, three's a crowd''.
Victorians are entitled to ask whether they were better off when the ARL and News Ltd ran the game, given that Rupert Murdoch has tipped in $65 million to the Storm and successfully lobbied for a rectangular stadium in the AFL city.
Roy Masters is a Sports Columnist for The Sydney Morning Herald
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Ignatius Rigor
At 330 miles above the Arctic Circle, life has never been easy for those brave enough to call Barrow home. The population currently hovers around 5,000 and about half of the residents are native Inupiat Eskimo, indigenous people who have survived for centuries by relying upon subsistence hunting and whaling. Continue reading


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We are bit confused.
if we read the news in english and get it translated in local language(not ditto line by line transaction) and publish it somewherethen does copy right from original content applies...
Some figures and othe information may be same...
how are things defined?
I'm not a lawyer, don't hold a law degree and certainly don't know much about law outside the US where you may be given your desire to translate articles... however as a general rule of thumb making a derivative work [that is a variation of what someone else made but clearly based on the original] would fall under the original copyright. The fact that you translated the article does not give you any rights to it.
There are fair use statutes that help protect certain sub-uses around media, education, humor, etc so depending on exactly what you are doing you may be able to claim one of those but they are not explicit rights and instead have to be supported if you are challenged.
Lets make this simplier what if i read the article and then rewrite it on my ownwhat do you think about that?
more over how do you prove that the work is re written formfor eg,some days ago there was news of zukerburg saying 'we made bunch of mistakes'...when i googled i found more than 200-300 big sites which has virtually 85% same thing but just language was different...
how do you define that?and specially sports news i find even local main newspaper of many countrries rewriting or bluntly saying translating the thing in local language.After all every newspapers of world doesnt have sports correspondent covering english premiere league in england.
If you write a news story based on the 'facts' you obtained from other sources, of course there is no problem. However, a direct translation may be problematic IMO.
well,thanks for the thoughts
I have said earlier that there wont be line by line translation.The original content will be read and rewritten in local language.
but information is going to be same....(which i think it falls into grey area now.Infact it may have been copied or information taken but may be hard to prove)
Now if somebody does same with my content ,how do i prove that it has been copied from me and copyrights are reserved on me?


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Held Hostage by the Fiscal Cliff
Did anyone really think the market wouldn't see some dips on fiscal cliff worries? Senator Harry Reid did the honors today with comments about how there has been little progress, but he added that he is confident that the Republicans will eventually see that the only correct course of action is to agree with him, so he isn't too worried.
You can be sure we will have plenty of market-moving headlines in the days ahead. The market is going to be held hostage by these negotiations, and while I'm confident that there will eventually be a positive resolution, there is likely to be a high degree of volatility while we wait....133 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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Press release
From UNC Asheville Athletics
HIGH POINT, N.C. – UNC Asheville senior forward picked up her 1,000th career rebound against Big South Conference foe High Point on Thursday evening, but a second half surge by the home-standing Panthers earned HPU a 49-35 victory over the visiting Bulldogs at the Millis Center.
Kelli Riles finished the contest with 12 points and 11 rebounds, giving her nine double-doubles on the season. She entered the contest with 989 boards. Riles now is also sitting at 992 career points, with four games left to play this year.
With the setback the Bulldogs drop to 2-23 on the season and 0-14 in the Big South. High Point improves to 15-9 overall, and 9-4 in league play.
Cheyenne Parker led the Panthers offensively, finishing with a game-high 13 points after only scoring two in the first half. She also pulled down a game-best 17 rebounds for her 20th double-double of the season.
Paige Love finished with 11 points for the Bulldogs, with Gentry Manley posting nine rebounds in the contest. Asheville converted 12-of-48 field goal attempts, including 1-14 from behind the 3-point arc.
High Point didn't fare much better, converting 19-of-58 shot attempts for a 32.8 percent average, while hitting 3-of-10 treys.
In the first half both teams struggled shooting the ball, with the Bulldogs and the Panthers each converting just seven field goals. HPU led by as much as four points, when Parker hit a putback layup with 7:45 to go to give the Panthers a 15-11 lead.
The Bulldogs would finish the frame on an 8-0 run, with Riles putting Asheville up 19-15 heading into the half on a reverse layup with 2:11 to play.
The second half saw the Panthers go on an 11-0 run before a Grace Blaylock trey cut the lead to 26-22 with 15:11 to go. HPU eventually pushed their lead to 43-24 with 7:09 to play on a Lindsay Puckett layup, giving the Panthers their largest lead of the night.
The Panthers would hold the Bulldogs at arm's length the rest of the way, eventually winning 49-35, and outscoring Asheville 34-16 in the second half.
The Bulldogs will travel to Buies Creek, N.C., for their next contest, taking on the Camels of Campbell University on Saturday at 4:30 p.m. The Camels earned a 73-56 victory over the Blue & White on Dec. 1, in the first Big South Conference game of the season for both schools.


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FLOWERY BRANCH — Mike Smith is facing the biggest challenge of his six seasons as the Falcons' coach.
Smith lost back-to-back regular-season games in only one of his first five seasons — in 2009 — and never lost more than two straight. Now the Falcons, who play Tampa Bay on Sunday, have lost three straight for the first time with Smith.
Matt Ryan and other players say it has been important to see Smith's demeanor remain steady during the crisis.
"Smitty, one thing about him in six years, he is consistent," Ryan said Wednesday. "Day in and day out, he comes to work positive and ready to go. I think players appreciate that, respect that and I think feed off of that and understand he's taken this approach and we need to do the same. We need to come in here positive and upbeat and ready to work."
The Falcons are 1-4 one year after playing in the NFC championship game. Injuries to key players have added significant difficulty to Smith's challenge.
Julio Jones, who was the NFL's leading receiver, had surgery on Monday for his season-ending foot injury. Three more starters on offense — running back Steven Jackson, receiver Roddy White and left tackle Sam Baker — did not participate in Wednesday's practice. Linebacker Akeem Dent and backup tight end Chase Coffman also were held out.
Jackson has missed three straight games with a hamstring injury. Baker (knee) did not play in the 30-28 loss to the Jets on Oct. 7 before the Falcons' bye week. White, already limited by an ankle sprain, strained his hamstring against the Jets.
Running back Jason Snelling returned from a concussion this week. Smith on Wednesday left open the possibility other injured players could return this week.
"I think we accomplished what we needed to accomplish during the bye week in terms of our evaluation," Smith said. "Now we've got some guys who have gotten some rest. Hopefully we'll get some guys back who have missed some time."
White has never missed a game in his nine NFL seasons. His streak of 133 consecutive regular-season games played is on the line this week.
The losses and injuries might be expected to cause signs of strain, especially since any losing streak is a new experience for Smith. Safety Thomas DeCoud said players would panic if they saw any changes to Smith's approach.
"That would be scary for us if we saw that coach Smith was changing his demeanor, and he's not doing that at all," DeCoud said. "He's helping us keep that even keel. If he was panicking it would go against everything that he's preaching.
"It's really good to have a coach who knows how to keep his cool and makes sure the message stays clear for the team so we can work on getting this thing right."
Mr. Continuity
Smith said he just tries to stay with the approach that has earned him a 57-28 record. He passed Dan Reeves in 2012 for the most wins in Falcons history.
"You do what you always do," Smith said. "I don't know that I put any thought into it. My job is to prepare the football team for them to go out and play their best. I know the way we've done it in the past and I'll continue to do that."
The Falcons took a streak of three straight playoff seasons into 2013. This week they're playing to stay out of last place in the NFC South, but Ryan said the recent history of success gives players confidence.
"Obviously we're not where we want to be, but you have to trust in what you do and you have to trust that we're going to make the plays," Ryan said. "I think remaining confident is incredibly important and we've got a whole lot of past success to keep us confident. Guys need to trust in that and trust in the process and just try to be a little more detail-oriented."


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Cittasanto wrote:I was talking about this not long ago here
johnny wrote:Beautiful. Is there anything the Dhamma doesn't cover? love it!
waimengwan wrote:I love the story of Angulimala!
The articles sounds like if we abandon negative actions and I sense there is regret in it as well then we will overcome our negative karma? Am I getting it right? If i get that right then just with regret and not doing those actions again I will purify my karma? [/color]
[color=#BF0000]Dear waimengwan,
I think the Buddha's advice in this sutta is to acknowledge our wrong deeds and repent, Once the acknowledgement is open-mindedly made, we then proceed to abandon the kamma effect through the Noble Eightfold Path development. Of course, no more wrong doing again, once we have understood that it is wrong/evil.
Coz Angulimala though he regret and stopped completely at some villages he was beaten to pulp. Do share if I have gotten it wrong.
sattva wrote:Thank you, Yawares
"What do you think, Malunkyaputta: the forms cognizable via the eye that are unseen by you — that you have never before seen, that you don't see, and that are not to be seen by you: Do you have any desire or passion or love there?"
"No, lord."[1]
"The sounds cognizable via the ear...
"The aromas cognizable via the nose...
"The flavors cognizable via the tongue...
"The tactile sensations cognizable via the body...
"The ideas cognizable via the intellect that are uncognized by you — that you have never before cognized, that you don't cognize, and that are not to be cognized by you: Do you have any desire or passion or love there?"
"No, lord."
"Then, Malunkyaputta, with regard to phenomena to be seen, heard, sensed, or cognized: In reference to the seen, there will be only the seen. In reference to the heard, only the heard. In reference to the sensed, only the sensed. In reference to the cognized, only the cognized. That is how you should train yourself. When for you there will be only the seen in reference to the seen, only the heard in reference to the heard, only the sensed in reference to the sensed, only the cognized in reference to the cognized, then, Malunkyaputta, there is no you in connection with that. When there is no you in connection with that, there is no you there. When there is no you there, you are neither here nor yonder nor between the two. This, just this, is the end of stress."
http://www.accesstoinsight.org/tipitaka ... .than.html
[/quote]pegembara wrote:How about this one?
http://www.accesstoinsight.org/tipitaka ... .than.html
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Steve Cooper
This guy Hardy sounds like a left wing extremist to me. I was a fan til NOW….
Dan Hardy (@danhardymma) tweeted at 1:20 PM on Wed, Sep 19, 2012: When is open season on ignorant, red neck, misguided, phony-Christian assholes? I would love to shoot some of those.
Hardy was directing his hateful comments towards MMA fighter, Matt Hughes for posting some hunting photos on his website – http://t.co/l8t0fW3P
Contact UFC President Dana White – https://twitter.com/danawhite
Posted from WordPress Wireless


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Thank you, dear friends, for your kind prayers. Sadly, I am not brave at all. If you had seen me as I sat dejectedly on the edge of the operating table as they shoved the epidural into me, you would not think me brave at all, for I was trembling and shaking like a leaf. One feels so vulnerable and completely out of control of the situation at such times.
Quote from: Fr. George on January 15, 2017, 04:25:33 PMI don't typically presume to speak for Mor You can presume to speak for Mor.
I don't typically presume to speak for Mor
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Editor's note: This market commentary is provided by the Dairy Division at FCStone/Downes-O'Neill in Chicago, Ill.
Class III prices traded light volume, failing to reach the 1k mark in volume yesterday, as just 850 trades occurred and prices were lower across the board from July 2011 all the way out to June 2012. After trading mixed early, prices declined following the spot cheese session which saw both blocks and barrels close unchanged. It appeared the damage could worsen when the butter market dropped 5.5 cents, but the buying there left sellers of Class III not feeling the need to get over-aggressive.
As was the case with the more surprising butter estimate from the USDA's Cold Storage report, little reaction was seen to what we would call a bullish cheese estimate. Despite the slight decline in American cheese stocks, it is hard to believe this report will have a positive impact, as a stocks draw-down is just what we saw in March which proceeded a near $3.00 /cwt. decline from March into April.
We look for Class III to open soft, for spot to be steady to lower and for futures to close lower
It was an incredibly active day in the butter markets, as participants seemed to be gearing up ahead of yesterday afternoon's cold storage report and motivated further by the spot price decline. Futures were active from the beginning of the session, as sellers were the aggressors. On the day, 372 contracts traded and prices from July through November were down 3.500 to the limit 5.000 cents on a whopping 368 trades. December settled a penny lower, as well, with 4 trades rounding out a total volume of 372 contracts.
In spite of the weakness, and a 5.5-cent drop in the spot market on six trades, futures did close with bids in most cases sizeable bids resting at their closing prices. After what we termed as a bearish report yesterday afternoon, prices saw almost no reaction having done their work it seemed prior to the release. While the massive increase in stocks is still somewhat of a mystery, this market does still appear to be very two-sided, as buyers are more than willing to purchase futures on price dips. Our inclination following the report is to say that a test of the $2.00 mark appears likely, but with the aggression of buyers in not only futures but the spot market, as well, it is looking like it will be difficult for futures to fall that far unless some weakness is seen overseas.
We look for butter futures to open mixed.
And, we look for corn to open 5 to 8 cents lower; soybeans to open 2 to 4 lower.
Daily CME spot market prices:
Block cheese: $2.13 (unchanged)
Barrel cheese: $2.0675 (unchanged)
Butter: $2.085 (down 5.5 cents)
Grade A NFDM: $1.6375 (down 0.25 cent)
These data and comments are provided for information purposes only and are not intended to be used for specific trading strategies. Commodity trading is risky and FCStone Group, Inc., International Assets Holding Corporation, and their affiliates assume no liability for the use of any information contained herein. Although all information is believed to be reliable, we cannot guarantee its accuracy and completeness. Past financial results are not necessarily indicative of future performance. Any examples given are strictly hypothetical and no representation is being made that any person will or is likely to achieve profits or losses similar to those examples. References to and discussions of exchange traded products are made solely on behalf of FCStone, LLC. References to and discussions of OTC products are made solely on behalf of INTL Hanley, LLC, and OTC products are only available to eligible counterparties.
Source: FCStone/Downes-O'Neill


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A Plague and a Blessing in My Empty Nest
September 25, 2017,
Erythema multiforme is a skin disorder that comes from an allergic reaction or infection.
Lyell's syndrome; Stevens-Johnson syndrome; Erythema multiforme minor; Erythema multiforme major
Erythema multiforme is a type of hypsersensitivity reaction. It occurs in response to medicines, infections, or illness. Medications that can cause this reaction include:
Infections include:
The exact cause is unknown. The disorder may start with damage to the blood vessels of the skin, that is followed by damage to skin tissues.
Some forms of this condition are more severe than others.
Erythema multiforme occurs mostly in children and young adults.
Other symptoms may include:
You doctor will look at your skin to diagnose this problem and ask if you have a history of risk factors or related diseases.
Tests may include:
Treatment goals include:
Your doctor may have you stop taking any medicines that may be causing the problem. Do not stop taking medicines without talking to your doctor first.
Treatment of mild symptoms may include:
Treatment of severe symptoms may include:
Good hygiene and staying away from other people may help prevent secondary infections.
You may need skin grafting if large areas of the body are affected.
Mild forms of erythema multiforme usually get better in 2 - 6 weeks, but the problem may return. More severe forms may be hard to treat. Stevens-Johnson syndrome and toxic epidermal necrolysis have high death rates.
Go to the emergency room or call the local emergency number (such as 911) if you have symptoms of erythema multiforme. Get emergency help immediately if a large area of the body is affected.
In: Habif TP, ed. Clinical Dermatology . 5th ed. Philadelphia, Pa: Mosby Elsevier; 2009:chap 18.
Weber DJ, Cohen MS, Morrell DS, Rutala WA. The acutely ill patient with fever and rash. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Disease . Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 52.


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Mission: Our mission is to provide care and shelter for stray, abandoned and abused cats and dogs in our community; to place these animals in stable and loving permanent homes; to promote and provide spay/neuter surgeries to reduce the animal population; and, to make the public aware and educate the community on the proper care and treatment of all animals.
General Information Our Friend for Life Center is strictly provided to help the animals of Barnwell County. The Animal Advocates pull adoptable animals from the Barnwell County Animal Shelter that would otherwise be euthanized. It is our policy that we cannot accept animals from the public.
Tuesday-Saturday: 11AM-3PM
All other days/hours please schedule an appointment ahead of time
All of our animals are current on vaccines and have been spayed/neutered (unless too young in which case we have adopters sign a spay/neuter agreement).
Fees for the dogs vary depending on breed, age and temperament but are generally between $125-$175.
All cats/kittens are $95
Thank You!
Your message has been sent to Animal Advocates.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


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As the 2011-2012 winter season takes its final turn into the homestretch, major resorts like Park City Mountain Resort are looking to make the sprint to the finish as affordable for their guests as possible.
The Wasatch Mountain resort has two stay-and-ski/snowboard packages that run until March 10, and a three-pack of similar deals that run to near or at season's end. All deals require multi-day stays and include tickets and lodging.
A group that books at least four nights for four people through Park City Mountain Reservations (800-331-3178) gets a discount price of $79 per person (the fourth night free). Three-day lift tickets for four adults are included for this deal that ends March 10.
Parents who show up for seven nights with two children get lodging for everyone for seven nights and six-day lift tickets for the adults. The cost of lodging varies, according to date of stay, and this deal ends March 10.
For those who are planning to hit Park City Mountain before April 12, a couple of packages are available. First, a three-night booking earns a free fourth night and discounted three-day tickets. Price varies according to date. Second, a family with two adults and two kids who stay at least five nights in slopeside lodging get free tickets for four days for the whole family. The children stay free, and this deal runs through April 15.
Finally, there's still time to take advantage of the season-long Winter Getaway Package, which offers a fourth night free after three nights paid, complimentary breakfast and two three-day adult lift tickets. This deals runs to the end of the Park City season, on Sunday, April 15.
For information and booking, click here.


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Visual Musing: Prints by William Kentridge
February 25–June 19, 2011
This exhibition brings together two recent series of prints by Kentridge,
Thinking Aloud
(2004) and
(2007–2009). Both bodies of work blend his own visual iconography with that of stories from literature and theater. Composed of his expressive and richly layered marks, the prints demonstrate his mastery of intaglio processes. Kentridge's works reveal a lively sense of improvisation and the unexpected unfolding of metaphorical associations.
Curated by Eric Lutz, associate curator of prints, drawings, and photographs, with Ann-Maree Walker, research assistant,
Visual Musing: Prints by William Kentridge
will be on view in Gallery 337 from February 25 through May 22, 2011.
Back to Archive


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Gundam, Saint Seiya, Death Note, and more
Right now, HobbyLink Japan continues to carry a fantastic selection of Japanese import goods, action figures, models and collectibles including...
* Halloween Specials!
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Check out the HobbyLink Japan Sale Section and Special Sale Section to find a huge variety of collectibles at a savings of up to 70%!
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text: Instant Text Updates Available at Chicago Auto Show FOR MORE INFORMATION, CONTACT: Diane St. James, Media Relations Director, Text2Drive 331-645-2971 cell email@example.com FOR IMMEDIATE RELEASE February 5, 2014 Instant Text Updates Available at Chicago Auto Show Two-way texting will debut for first time ever at event CHICAGO – Navigating more than one million square feet of exhibition space can seem daunting to anyone, so it's natural for enthusiasts at the Chicago Auto Show to wander around wondering what to check out first, when a special event is about to happen, and how to get there. But this year at the largest U.S. auto show, a personal tour guide is coming to a phone near you! Everyone with a cell phone can text the keyword "AtTheShow" to the short code DRIVE (37483) to get timely updates on events, attractions, promotions, contests, celebrity appearances and other news happening at the 2014 Chicago Auto Show -- sent directly to their own phone. "The unique aspect of this is the real-time info; there's no delay," said Mark Bilek, Director of Communications Technology for the Chicago Auto Show. "If a Bulls player, for example, is not on the schedule and shows up, we can text that. We have a way to reach people and let them know." Bilek is delivering the text updates to Chicago Auto Show visitors with the help of Text2Drive, the premiere two-way text communication tool used by more than 400 car dealers across the country to send and receive text messages to and from their customers. "Text2Drive is cutting through the clutter to put the most important and timely information about the Chicago Auto Show in the palm of your hand," explained Text2Drive CEO Gregg Owen. "You don't have to fumble with a program or map or search for the help desk. You can easily and conveniently find out where to sign up for the sweepstakes drawing or which interactive display has the shortest line or when a Chicago Bears player is due to appear – all through texting on your own cell phone." The press can get their own special text updates by texting the keyword CASMedia to the same short code, DRIVE (37483). For the first time ever, the Chicago Auto Show will provide live, instant answers to questions via text for those who text the keyword BetterState to the same short code, DRIVE (37483), on Sunday, February 9, 2014. It will be like having a mobile version of the State Farm Insurance Help Desk in every consumer's pocket or purse. "That's what I'm excited about, two-way conversations with attendees," enthused Bilek, adding that the special beta-test of the two-way texting will continue during the week at times when staffing is available. Bilek's own staff will be using the Text2Drive platform to communicate with each other and post timely information and pictures to social media. "Text2Drive created an app that allows employees to take a picture with their phone, attach a message to it and then send it directly to the communications department," explained Owen. "The employees in the Chicago Auto Show control room can then instantly post that picture and information to their social media pages right from the Text2Drive platform on their computer screen." With the constant noise on the showroom floor making communication difficult among Chicago Auto Show employees, Bilek says he's grateful they have a new, improved way of reaching each other. "Several years ago, I recognized texting was becoming a way of communication that wasn't being addressed at the Chicago Auto Show. Gregg Owen and I started working together on that," Bilek noted. "Now, in addition to giving people information through text notifications, we'll try two-way communication with text. It's pretty cool." Come check out Text2Drive at the Chicago Auto Show Media Preview days; watch a live demonstration of the cutting-edge communication tool and meet CEO Gregg Owen at 1:30 pm Friday, February 7, 2014, at the Grand Concourse Media Stage. #################################### Text2Drive offers video and sound to broadcast media at this link: http://www.youtube.com/watch?v=gOjVn3ZpkA4 Back to News


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Minor in Film Studies
Film Studies at Murray State University
The Film Studies minor at Murray State University is an interdisciplinary program that complements many majors and provides opportunities for students to examine film as an art form, as an industry, and as a communication medium. Courses in the minor emphasize the history, theory and practice of film in the larger context of liberal arts studies and thus enhance students' understanding of this important medium and its influences across the disciplines. In consultation with faculty, staff and advisors, students may select elective courses within the Film Studies minor relevant to their academic and career objectives.
Film Studies Minor: 21 hours
Both of the following:
ENG 313 History of the Cinema (3 Hours)
ENG 314 Shakespeare in Film (3 Hours)
One of the following:
ENG 315 Global Cinema (3 Hours)
ENG 419 European Cinema (3 Hours)
FRE 419 European Cinema (3 Hours)
GER 419 European Cinema (3 Hours)
SPA 419 European Cinema (3 Hours)
One or two of the following:
ART 382 Introduction to Photography I (3 Hours)
ART 383 Photography II (3 Hours)
ART 384 Photography III (3 Hours)
ART 385 Introduction to Cinematography (3 Hours)
JMC 270 Basic Audio/Video Production (3 Hours)
JMC 336 Script Writing (3 Hours)
ENG 343 Special Topics in Creative Writing (3 Hours)
ENG 460 Comedy and Satire (3 Hours)
Two or three of the following:
ART 490 Special Problems in Studio Art (3 Hours)
ENG 213 The Film and Literature (3 Hours)
ENG 351 Special Topics in Film Studies (3 Hours)
ENG 417 Film in the Classroom (3 Hours)
HIS 477 Hollywood History (3 Hours)
JMC 358 Television Studio Production (3 Hours)
MUS 106 Music in Film (3 Hours)
MUS 313 Introduction to Music Synthesis (1 Hour)
May only include one of the following:
ENG 341 Introduction to Writing Fiction (3 Hours)
ENG 342 Introduction to Writing Poetry (3 Hours)
ENG 415 Writer's Workshop: Short Story (3 Hours)
ENG 416 Writer's Workshop: Poetry (3 Hours)
Students may select an optional course substitution, such as the one cited below,
with the permission of the coordinator of the Film Studies Minor and the instructor:
CSC 275 Graphical Rendering (3 Hours)
At least six hours must be upper-level courses completed in residence at Murray State University. Students must remember that courses taken for their majors cannot count toward a minor.
The requirements listed above are an example of what is applicable to most students entering Murray State University under the 2013-14 academic bulletin. Criteria as they may relate to individual students may vary. The primary source is the MSU bulletin applicable at the time of the student enrollment; if you enrolled prior to the 2013-14 academic year, consult the registrar's listing for your applicable bulletin.


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7 Hot Stocks to Trade (or Not) BALTIMORE ( Stockpickr) -- Put down the 10-K filings and the stock screeners. It's time to take a break from the traditional methods of generating investment ideas. Instead, let the crowd do it for you. From hedge funds to individual investors, scores of market participants are turning to social media to figure out which stocks are worth watching. It's a concept that's known as "crowdsourcing," and it uses the masses to identify emerging trends in the market. >>5 Stocks Setting Up to Break Out Crowdsourcing has long been a popular tool for the advertising industry, but it also makes a lot of sense as an investment tool. After all, the market is completely driven by the supply and demand, so it can be valuable to see what names are trending among the crowd. While some fund managers are already trying to leverage social media resources like Twitter to find algorithmic trading opportunities, for most investors, crowdsourcing works best as a starting point for investors who want a starting point in their analysis. Today, we'll leverage the power of the crowd to take a look at some of the most active stocks on the market today. >>5 Stocks Insiders Are Scooping Up These "most active" names are the most heavily-traded names on the market -- and often, uber-active names have some sort of a technical or fundamental catalyst driving investors' attention on shares. That's especially true now that earnings season is officially underway. And when there's a big catalyst, there's often a trading opportunity. Without further ado, here's a look at today's stocks. >>5 Rocket Stocks to Buy This Week Chesapeake Energy Nearest Resistance: $21.50
Nearest Support: $19.50
Catalyst: CEO Retirement On the other side of the spectrum, Chesapeake Energy ( CHK) is rallying hard following news that embattled CEO and co-founder Aubrey McClendon would be stepping down from his post on April 1. No, it's not just an early April Fool's joke. McClendon, you'll remember, was at the center of a debacle where he'd borrowed around a billion dollars against his holdings in CHK to fund personal stakes in wells used by Chesapeake. Since that came out, the tenuous relationship between McClendon and the board has been grabbing more headlines than Chesapeake's own business has.
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Being a Giants Season Ticket Member means more than just great seats to baseball games at AT&T Park. It's really a package of exclusive perks, privileges and special opportunities. Additionally, as a Season Ticket Member you receive great savings on your tickets compared to single game buyers who pay dynamic prices.
My SF Tix - You can sell, electronically transfer and donate game tickets using their My SF Tix account. Your season ticket location is automatically populated into your account, meaning that you do not have to enter barcodes to add the tickets.
Regular Season Single Game Ticket Presale - With the demand for tickets being so great, you can purchase single game tickets before they go on sale to the general public. Don't miss out on your opportunity to secure extra tickets for the most popular games, including the Dodgers and A's. Details and your unique password will be emailed to you in advance of the presale.
Postseason Ticket Access - One of the biggest benefits is access to your seats for postseason games. If the Giants are in the postseason race, you can expect to receive information on how to secure your playoff tickets in August or September.
Spring Training Single Game Ticket Presale - Tickets for Cactus League games at Scottsdale Stadium in Arizona are offered to you in advance of the general public during a special presale. Be sure to check for email updates in December for the date of the 2014 presale.
Presale for Non-baseball Events at AT & T Park - This ballpark is the place to be and not just for baseball. You may receive offers to purchase tickets for non-baseball events such as concerts, college football bowl games and more.
Please note that Season Ticket Member benefits are time-sensitive and subject to availability.The San Francisco Giants reserve the right to discontinue any benefit at any time.
Client Relations Account Manager - You have an "inside connection" at the Giants! Your personal Client Relations Account Manager is available year round to assist you with all matters associated with the Giants and your experience at AT & T Park. Always make your account manager your first point of contact if you have any questions, feedback or concerns. Your account manager can be reached via phone or email. Client Relations Staff Directory »
Season Ticket Member HOTLINE - Whether you have a quick question or an urgent gameday issue, you can call 415-972-BALL (2255). This line is staffed during regular business hours and up until second inning on game days for quick access to a live person.
Premium Seating HOTLINE - Field Club and Club level Charter Seatholders can reach a dedicated representative at 415-972-2424 for assistance.
Payment Plan Options - There are several installment options to spread your season ticket payments over several months. You can select the payment plan that best suits your needs.
Replacement Tickets - Your season tickets should be stored in a safe and secure place, just like cash. But in the event that your tickets are lost or stolen, please contact your Client Relations Account Manager for assistance with replacement tickets.
Season Ticket Member Appreciation Event - The annual summer event will include free food, beverages, access to the field and a Chalk Talk with players and broadcasters.
Batting Practice Field Visit (Early Bird Sweepstakes Prize) - A select group of sweepstakes winners will receive an invitation to watch the Giants take pre-game batting practice from the field.
"Inside the Clubhouse" Filming - Opportunity for a select group of randomly selected Ticket Members to attend a taping with our General Manager, Team Manager and Front Office Executives.
Spring Training Season Ticket Member Weekend - Annual Season Ticket Member Weekend and party with the player at Spring Training. More about Giants Vacations »
Special Gift - As a thank you to our most valued fans, you will receive a special holiday or preseason gift (or exclusive experience) from the Giants and your Client Relations Account Manager.
Season Ticket Member ID Card - This card not only identifies you and your ticket partners as season Ticket Members, but it also gives you a 20% off discount for Dugout Store purchases during the 2014 season (restrictions apply). Look for your ID card in the back of your season ticket booklet.
Season Ticket Member Sweepstakes - By submitting your season ticket renewal by the December 4 deadline or rolling over your Post-season credits with the "I'm In plan, you get qualify for the opportunity to win trips, special ballpark experiences, autographed items and other prizes offered in this exciting Sweepstakes program. Details will be included with your annual renewal information. New for 2014 is the 30 Prizes in 30 Days Promotion! See Official Rules
Season Ticket Member Website - Are you looking for helpful tips, news or "insider" information? Everything that you need to know about being a Season Ticket Member can be found at sfgiants.com/seasontickets, so bookmark this page as one of your favorites!
Email Updates - You will receive regular informational emails from your Client Relations Account Manager providing you with news and important information regarding your San Francisco Giants. Special offers will also be sent via email so be on the lookout for these updates.


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Aqua Floral Beach Towel
No longer available
- Overview
Watercolor-style blooms make sunny days even brighter. Woven to a plush 400-gram-weight, our color-splashed towel is a treat to wrap up in after a swim.
- 32 x 64"
- Made of 100% cotton velour.
- 400-gram weight.
- Reverses to cotton terry.
- UVF-50 sun protection.
- Personalization is available for an additional $9.50.
- Click here to Preview Font Colors.
- Machine wash.
- Imported.
- Dimensions + Care
- Machine wash in warm water, gentle cycle.
- Use only non-chlorine bleach, if needed.
- Tumble dry on low heat; remove promptly.
- Shipping Info
This item will arrive in 3-5 business days. Please proceed to the Payment & Review page of Checkout for a precise delivery estimate.


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DC Super-Villain This December...
DC Collectibles reveals a new DEATHSTROKE action figure. Part of their DC Super-Villains series, Deathstroke will stand 6.85" tall, feature multiple points of articulation and include character specific accessories. Look for him in December 2013 priced at $24.95.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, AlterEgoComics.com, PlasmaInfusion.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


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I Hope Gold Comes Down Even More
Gold can't catch a bid. We hear a million reasons why: The Federal Reserve wants interest rates lower, the dollar is strong, the chaos in Europe is over, China's stabilized.
I have to tell you that every one of those is a pile of hooey. Gold, using the SPDR Gold Trust (GLD) as the proxy, has now gone from $184 down to $159 from mid-2011 until now. During that period, we did have chaos overseas. But we also had a strong dollar and a dovish Fed. During the previous 12 years we saw all of these circumstances that are now being credited for gold's weakness -- and the precious metal rose every year....408 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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"Seek good and not evil, that you may live; and thus may the Lord God of hosts be with you, just as you have said!"(Amos 5:14, NASB).
[Thought questions for Seek the Lord and Live! May 1, 2013]
1. Making evil appear good and good evil. How was it possible for Israel to stumble in sin and make their relationship with God a mockery? Couldn't they remember the mighty works God had done on their behalf? Are people today ever tempted to make something evil seem as if it's not so bad after all? Which is the greater sin–seeing evil as good or seeing good as evil? Either way, how do these positions lead people from God?
2. A hollow religion. Were you surprised the first time you read or heard that God was disgusted about the way His people observed the religious ceremonies He had set up for them? Can you imagine God or one of His angels speaking out to you and your family in such a way? What would bring about a judgment of a false religion? Have you attended church hundreds of times? Thousands? Has any of the excitement of your early years as a Seventh-day Adventist Christian faded away? Is it too late to revive in your heart a rousing spirit of worship that comes directly from your relationship with Jesus?
3. Amos the unpopular prophet. Why do you think the children of Israel would never have elected Amos to come and preach to them? Do you think they had a feeling that they were going to hear what they deserved from him–and that they didn't like it? In his prophecy against the northern kingdom, was Amos clearly placing himself on dangerous ground? What was Amaziah's advice? How would you like to go to church Sabbath and listen to a sermon condemning you and your family of apostasy? (Notice how every line of this book is part of a poetic chant or a tapestry of poetic words.)
4. Searching for the Word of God. Which could you tolerate better–not having enough food and drinking water to survive, or not having access to the Bible? Were the Israelites in Amos' day able to reach out to God and talk to Him? If so, why, then, was there a famine of God's Word? Is there ever a good excuse to live a life without God? Can you imagine a time coming soon when people will be frightened because they don't feel they have time to establish a strong relationship with God? What about babies and small children who may not live long enough to know Jesus? What is our responsibility in these times of approaching famine?
5. Ruins restored. Does your heart jump with joy when you read the "rest of the story" in Amos? How did God feel about restoring His people to their former state of prosperity and good will? Do you hear a familiar strain in the joyful refrain Amos shares with the Israelites? Remember when God encouraged His people to reach out to those in nearby countries and minister to them? Did this prediction come true? Does God repeat that promise to us today?
6. Think of these things. Is it possible to suffer from a "famine" of God's Word while attending church every Sabbath? Can a person read and study God's Word without obtaining the blessing or instruction God intends? Do we ever boast among ourselves about our superior knowledge of Biblical truth? What about that sort of attitude among those who do not share our church affiliation. Are we the most loving, caring people in the world? Are we welcome as neighbors in our community?


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Enter New Brunswick's 'Ten Days of Wonder' sweepstakes
Here's an opportunity to win a free trip to see the wonders that New Brunswick has to offer. Tourism New Brunswick is once again offering their highly successful sweepstakes. Go to their website to find out more and to enter……. www.tourismnewbrunswick.ca/10days/EN/index.html (more…)


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Peroral Endoscopic Myotomy for Primary Esophageal Achalasia (TAMEO)
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- How to Read a Study Record
|Primary Achalasia
|Procedure: Peroral endoscopic myotomy
|Phase 3
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Peroral Endoscopic Myotomy for Primary Esophageal Achalasia
- Percentage of patients with clinically significant perforation [ Time Frame: Day 1 after procedure ]
Clinically significant perforation is defined as an ensemble of procedural, clinical, biological and imaging parameters:
- perforation seen during procedure with placement of endoscopic metallic clips as closing method
- acute severe persistent pain, fever over 38.5°C, subcutaneous emphysema, pneumomediastinum, penumoperitoneum
- elevated white blood count with elevated neutrophils and elevated CRP, ascending values
- subcutaneous emphysema, pneumomediastinum, penumoperitoneum seen at imaging studies (day 1 CT scan)
- percentage of patients with Eckardt score less than 3 [ Time Frame: at 3rd and 12th month after procedure ]Eckardt score calculated at baseline and after procedure
- significant variation of Eckardt score [ Time Frame: at baseline and at 1st, 3rd, 6th and 12th month after the procedure ]Eckardt score calculated at baseline and after procedure
- significant variation of GIQLI score [ Time Frame: at baseline and at 1st, 3rd, 6th and 12th month after the procedure ]GIQLI score calculated at baseline and after procedure
- significant variation of high resolution manometry parameters [ Time Frame: at baseline and at 3rd month after the procedure ]high resolution manometry performed at baseline and at 3rd month after the procedure
|Study Start Date:
|March 2012
|Study Completion Date:
|January 2015
|Primary Completion Date:
|January 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Single Arm
Peroral endoscopic myotomy
Procedure: Peroral endoscopic myotomy
An endoscopy is performed under anesthesia with orotracheal intubation. After submucosal saline injection, an entry point in the submucosal space is created at 10 cm above the cardia. The endoscope will create a 12cm long tunnel in the caudal direction by submucosal dissection, stopping at 2cm below cardia. Then the muscular circular internal layer is sectioned on a 9cm length, starting 3 cm below the submucosal entry point. At the end the submucosal entry point is closed with metallic clips. A scanner is performed after the procedure so as to check the esophageal wall integrity. Alimentation is progressively introduced at day 1.
This is a study of a procedure - peroral endoscopic myotomy (POEM). No new, unapproved device is used. All endoscopic tools are already approved for endoscopic submucosal dissection and associated complications (hemorrhage or perforation): dissection knifes, hot biopsy forceps, endoscopic metallic clips.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients of both sexes aged over 18 years old
- Patients who have signed the informed consent form before any study related procedure
- Primary achalasia of the cardia with Eckardt score > 3
- Non sigmoid achalasia or S1 sigmoid type achalasia at barium meal Rx study
- ASA score (American Society of Anaesthesiologists) 1 or 2
- Patients affiliated to a social security health system
Exclusion Criteria:
- Patients with age less than 18 years old
- Patients without discernment with legal protection
- Patients who will not be able to abide with study follow-up as judged by the investigator
- Patients which cannot provide a written informed consent
- Patient refusing to participate in the study, without informed consent
- Pregnant or breastfeeding women, women in fertile age for procreation without efficient contraception, and/or positive serum βHCG test
- Concomitant participation in other clinical trial
- S2 sigmoid type primitive achalasia of the cardia
- Pseudo-achalasia (esophageal carcinoma),
- History of Barrett's esophagus with or without dysplasia, malignant tumors of the esophagus
- History of esophageal strictures, systemic sclerosis
- History of esophageal varices
- History of endoscopic or surgical therapy of the esophageal achalasia
- History of inferior endoscopic or surgical esophageal sphincter manipulation (sutures, polymers injection, adhesive bands)
- History of surgical interventions of the esophagus or stomach (fundoplication, Heller-Dor myotomy, gastric resections, vagotomy with or without gastric drainage)
- History of congenital of acquired coagulation anomalies: hemorrhagic diseases, hemostasis disturbances (TP < 60%, TCA > 40 seconds, platelets < 60000/mmc)
- ASA score (American Society of Anaesthesiologists) 3, 4, 5 or 6
- Cancer, liver, respiratory, renal or heart failure which put the patients in the ASA risk group 3,4,5 or 6.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01560559
|Clinique de Hépatogastroentérologie
|Lyon, France, 69003
|Principal Investigator:
|Thierry PONCHON, Pr
|Hospices Civiles de Lyon
|Responsible Party:
|Hospices Civils de Lyon
|ClinicalTrials.gov Identifier:
|NCT01560559 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 6, 2012
|Last Updated:
|May 22, 2015
Keywords provided by Hospices Civils de Lyon:
Primary esophageal achalasia
endoscopic myotomy
high resolution manometry
Additional relevant MeSH terms:
Esophageal Achalasia
Esophageal Motility Disorders
Deglutition Disorders
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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Site for the Infosistema eTest product. Infosistema eTest is a knowledge test and assessment platform.
|Public Website
|Software / IT
Jul 12, 2017 - OpenCms 10.5.2 is a maintenance release for OpenCms 10.5. This version fixes a number of issues that have been detected in OpenCms 10.5, and includes several performance and some security enhancements. It also ships with the versatile, Bootstrap based Apollo Template. An updated version of Alkacon OCEE is available as well.
Jul 12, 2017 - The OpenCms 10.5.2 release notes contain detailed information about the new features and fixes in this version.
© Alkacon Software GmbH & Co. KG - http://www.alkacon.com - Terms of use - Impressum


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Grab This One After the Slide
Tough market days like Monday, when the Dow dropped more than 216 points, provide second chances. Stocks that seemed as if they would never come back to earth get hit in sympathy with most other shares.
Air Products & Chemicals (APD) is one of those stocks -- a high-quality name that has pulled back from a 2011 peak of $98 to close Monday at $84.23. Air Products' price stability and earnings predictability each rate among the top 10% to 20% of all companies, and the $0.64 quarterly dividend provides a 3.15% current yield. That may well increase soon, as well, since management typically raises the payout during the June quarter....240 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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With beautiful sunny skies and the temperature soaring upwards of 75 degrees, our Closing Day Celebration at Morey's Piers on Sunday felt more like an idyllic summer day! Lots of families spent the day together enjoying the amusement rides, live entertainment and delicious specials at our food concessions.
On this special day, live entertainment and fun activities are found everywhere on the pier. Children's faces lit up with wonder while taking in the magic of the fascinating magician. The pier was filled with little ones carrying their funny balloon animals crafted by the stilt walker. And, of course, the face painters continue to be an all-time favorite, delighting children with whimsical butterflies and daring action figures painted on their arms and faces.
One of the highlights of the afternoon was a jamming dance party with Radio Disney. Children, and even some daring parents, joined in the fun and danced their hearts out to the latest tunes from Disney's hottest musical artists. DJ Kenny entertained the crowd with fun Radio Disney trivia games. The lucky winners got VIP passes to come back next summer and enjoy the piers and waterparks for free!
And for our guests who love our classic boardwalk fare, there were all kinds of great buy-one-get-one deals. All our concession stands had tasty treats available for our Last Day Celebration. Everything from cotton candy to pizza, and soft pretzels to funnel cake, were available to our guests so they could enjoy one last taste of summer.
And so another exciting season comes to an end at Morey's Piers. Hopefully the wonderful memories you've made while visiting us will keep you warm this winter. We've already begun making BIG plans for another super summer season here in 2009. Until then, have a happy and healthy winter, and we'll see you in the spring.
Your friends at Morey's Piers