text:
Study of Dolutegravir (DTG) on PK of Cenicriviroc (CVC), and CVC on PK of DTG & on a Single Dose of Midazolam
This study has been completed.
Tobira Therapeutics, Inc.
ViiV Healthcare
Information provided by (Responsible Party):
Tobira Therapeutics, Inc.
ClinicalTrials.gov Identifier:
First received: March 25, 2013
Last updated: April 8, 2014
Last verified: April 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
To evaluate the PK, safety and tolerability of Cenicriviroc (CVC) administered with and without Dolutegravir (DTG) and CVC with and without a single dose of Midazolam in healthy subjects.
|Drug: Cenicriviroc Drug: Dolutegravir Drug: Midazolam
|Phase 1
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
|Official Title:
|A Phase I, Multiple-Dose, Open-Label, Crossover Study in Healthy Subjects to Assess the Effect of Dolutegravir (DTG) on the Pharmacokinetics (PK) of Cenicriviroc (CVC) and the Effect of CVC on the PK of DTG and on a Single Dose of Midazolam
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Midazolam maleate Midazolam hydrochloride Dolutegravir Dolutegravir sodiumU.S. FDA Resources
Further study details as provided by Tobira Therapeutics, Inc.:
Primary Outcome Measures:
- Pharmacokinetic Assessment of Cenicriviroc [ Time Frame: 0 (predose), 0.5, 1, 2, 3, 4, 6, 8, 10, 12, & 24 hours postdose on Days 10 and 20 ]PK profile will be calculated based on CVC exposure. Trough (predose) CVC plasma samples will be obtained prior to dosing on Days 2-9 & 12-19.
- Pharmacokinetic Assessment of Dolutegravir [ Time Frame: 0 (predose), 0.5, 1, 2, 3, 4, 6, 8, 10, 12, & 24 hours postdose on Days 10 and 20 ]PK profile will be calculated based on DTG exposure. Trough (predose) DTG plasma samples will be obtained prior to dosing on Days 2-9 & 12-19.
- Pharmacokinetic Assessment of Midazolam and alpha-hydroxymidazolam [ Time Frame: 0 (predose), 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 12 & 18 hours postdose on Day -1 and Day 9 ]PK profile will be calculated (Group 1 only) based on plasma midazolam & alpha-hydroxymidazolam exposure.
Secondary Outcome Measures:
- Number of participants with adverse events [ Time Frame: Participants will be followed upon taking first dose of study medication until the follow-up visit, an expected average of 5 weeks ]
Physical examinations, vital signs, ECGs, clinical laboratory tests, and AEs or serious AEs (SAEs) will be assessed at specified time points according to the Schedule of Procedures in the protocol. In addition, arterial oxygen saturation will be monitored by pulse oximetry for at least 2 hours after administration of midazolam on Days -1 and 9 in Group 1.
For both groups, a final follow-up visit will occur 14 days (±3 days) after the last dose of study medication, or at the time of early termination (if applicable) to evaluate any remaining safety issue(s).
|Study Start Date:
|March 2013
|Study Completion Date:
|May 2013
|Primary Completion Date:
|May 2013 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Cenicriviroc + Midazolam, and CVC + DTG
Grp 1: CVC 150mg qd alone from Days 1-10; CVC 150mg qd + DTG 50mg qd from Days 11-20. A single dose of midazolam 5mg administered alone on Day -1 & w/ CVC 150mg on Day 9.
Drug: Cenicriviroc
Other Name: CVCDrug: Dolutegravir
Other Name: DTGDrug: Midazolam
Other Names:
Experimental: Dolutegravir , and DTG + CVC
Grp 2: DTG 50 mg qd alone from Days 1-10, DTG 50 mg qd + CVC 150 mg qd from Days 11-20.
Drug: Cenicriviroc
Other Name: CVCDrug: Dolutegravir
Other Name: DTG
Detailed Description:
Primary Objectives
- To evaluate the steady-state PK of CVC administered with and without DTG .
- To evaluate the steady-state PK of DTG administered with and without CVC .
- To evaluate the PK of a single dose of Midazolam administered with and without steady state CVC when both are administered orally.
Secondary Objectives
- To evaluate the safety and tolerability of CVC administered with and without DTG.
- To evaluate the safety and tolerability of CVC administered with and without Midazolam.
|Ages Eligible for Study:
|18 Years to 55 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Provide written informed voluntary consent
- Adult male and female healthy volunteers
- Body mass index (BMI) ≥ 18.0 and ≤ 30.0 kg/m2.
- Be in good general health with no clinically relevant abnormalities
- Agree to comply with study procedures and restrictions
Exclusion Criteria:
- Any disease or condition that might affect drug absorption, metabolism, or excretion, or clinically significant cardiovascular as determined by investigator
- History of stomach or intestinal surgery, except for fully healed appendectomy and/or cholecystectomy which will be allowed
- Clinically significant illness or clinically significant surgery within 4 weeks before the administration of study medication
- Known or suspected hypersensitivity or allergic reaction to any of the components of CVC or DTG tablets, or midazolam syrup
- Serum ALT, AST, or bilirubin values greater than or equal to Division of Acquired Immunodeficiency Syndrome (DAIDS) grade 1 at screening
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01827540
Please refer to this study by its ClinicalTrials.gov identifier: NCT01827540
|United States, Florida
|SeaView Research, Inc.
|Miami, Florida, United States, 33126
Sponsors and Collaborators
Tobira Therapeutics, Inc.
ViiV Healthcare
|Principal Investigator:
|Audrey Martinez, MD
|SeaView Research, Inc.
More Information
Keywords provided by Tobira Therapeutics, Inc.:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 25, 2017
|Responsible Party:
|Tobira Therapeutics, Inc.
|ClinicalTrials.gov Identifier:
|NCT01827540 History of Changes
|Other Study ID Numbers:
|Study First Received:
|March 25, 2013
|Last Updated:
|April 8, 2014
Keywords provided by Tobira Therapeutics, Inc.:
Cenicriviroc (CVC)
Dolutegravir (DTG)
Healthy Subjects
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Adjuvants, Anesthesia
Hypnotics and Sedatives
Central Nervous System Depressants
Physiological Effects of Drugs
Anti-Anxiety Agents
Tranquilizing Agents
Psychotropic Drugs
Anesthetics, Intravenous
Anesthetics, General
GABA Modulators
GABA Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
HIV Integrase Inhibitors
Integrase Inhibitors
Enzyme Inhibitors
Anti-HIV Agents
ClinicalTrials.gov processed this record on September 25, 2017


text:
- Denver releases comprehensive retail report.
- Old University of Colorado hospital site has retail potential.
- Landing a Costco or SuperTarget could help stop sales tax "leakage"
Denver believes it is one step closer to establishing itself as an "exceptional retail city," even though it has yet to land a Costco.
The city today released a comprehensive study of Denver's retail strengths, weaknesses and opportunities to become a nationally recognized shopping destination.
The Denver Retail Conditions and Opportunities Study, prepared by retail consultant Economic & Planning Systems, contains a detailed analysis of Denver's retail reality as well as strategic recommendations for future growth.
"Denver has so many incredible assets, particularly in new urban housing, a booming business climate, and a strong array of entertainment options and dining experiences," said Denver Mayor Michael B. Hancock.
"But in several critical ways, our retail environment has not kept up with the growth in Denver," Hancock continued. "While we know the city offers a number of fantastic venues and stores for our neighbors and visitors to check out, this study demonstrates we have great capacity to support many more. That is why we will use this study as a roadmap to realize our existing potential to become a truly landmark retail city."
The presentation of the study on Wednesday to the Denver City Council's Business, Workforce and Sustainability Committee marks a major milestone in Hancock's commitment to strengthen Denver's retail economy. A 12-member, public/private Denver Retail Strategic Advisory Council, formed a year ago, oversaw the study's development and will provide insights and advice for the creation of a formal strategic plan for retail development in the city, expected later this year.
"The study highlights the opportunities we have in our blossoming downtown, Cherry Creek and Northfield retail areas," said Paul Washington, director of Denver's Office of Economic Development.
"Moreover though, the research also shows that Denver faces significant challenges in its quest for retail strength," Washington added.
"The study, and my discussion with the DRSAC members, highlights the importance of playing to our strengths – we will focus on the key retail locations and neighborhood districts to increase more unique, urban, destination retail. Retail today is about the experience, as much as the actual item purchased."
The study lists Denver's strengths in the retail sector overall to include its sales of "convenience goods," including groceries, health and personal care products, and liquor stores, with inflows from business travelers, visitors, and non-city residents. Denver also does extremely well in its eating and drinking establishments, with a number of chef-driven restaurants and the demand of convention and business travelers.
The study also acknowledges Denver's lack of general-merchandise retailers, such as Super Target and Costco, as one factor that contributes to what is being called the "leakage" of sales tax revenue out of the city and into surrounding areas.
This weakness in general-merchandise means that 65 percent of what city residents spend at warehouse or "big box" stores goes outside the city, in many cases to store locations just beyond Denver's borders, the study reported.
City residents also leave Denver to shop for home improvement, garden supplies, furniture, hobby, and music and books—with about 40 percent of their expenditures in these categories adding to the troubling rate of "leakage."
The study highlighted a number of opportunities for growth and retail redevelopment within Denver—including the former University Hospital site at Ninth Avenue and Colorado Boulevard, the University Hills Plaza, around the Interstate 70 and Brighton Boulevard interchange, and Sun Valley (the latter being around Sports Authority Field and an example of the transit-oriented opportunities). The study also gave high marks to Denver's emerging neighborhood business districts such as East Colfax, River North, and along South Broadway from 6th Avenue to Alameda.
And although limited, there are unused large-format retail sites in Denver, the study noted, including Alameda Square, Federal Bouevard Evans Avenue and Evans and Monaco (the latter two being former K-Mart sites).
These findings will help Denver's OED continue to work closely with DRSAC to address the city's weaknesses and build a stronger approach for both recruiting retail as well as redeveloping underused parcels and better serving underserved areas, Washington said.
"Shopping center development, and shopping in general, has changed dramatically in just two decades," Washington said. "OED is developing a toolkit of policies, programs and incentives for approaching retailers as well as GIS mapping technologies to enhance the city's retail development projects. Our pressures come from growth in online shopping and a lack of ready-inventory of physical spaces to develop in the way that today's shoppers want. This plan will help Denver adapt to this reality."
To read the report, please visit City and County of Denver, OED.
Have a story idea or real estate tip? Contact John Rebchook at email@example.com. InsideRealEstateNews.com is sponsored by Universal Lending, Land Title Guarantee and 8z Real Estate. To read more articles by John Rebchook, subscribe to the Colorado Real Estate Journal.

subset: commoncrawl


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Minneapolis on the SpareFoot blog:
The 20 Best Places to Open a Home Organizer Business
Getting organized might come easy for some folks, but some people need all the help they can get. Professional home organizers make a living doing just that—helping bring order to those who have mes...Read more.
The 12 Hardest-Working Towns in America
With everything Labor Day has come to symbolize—the end of summer, the beginning of the school year, a weekend of good deals at the mall—it can be easy to forget its purpose: to celebrate workers'.....Read more.
Best Cities for Dogs in the U.S.
Ah, a dog's life. It's pretty sweet, huh? You get petted. You get groomed. You get fed. You get loved. Some dogs in the U.S. have particularly great lives, though. We've singled out seven......Read more.


text:
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Garbage players get 1st round picks, (WTF)! All of the NBA must hate the Pacers! LOL
He plays the 6th man role.
Its not as much being "benched", more so Memphis starting arguably the best perimeter defender in the league in Tony Allen, as they should.
Stop quoting people I have on ignore!
Haha, hopefully there won't be a long line of name changes come the 15th.
As much as I like OJ Mayo, he's a little redundant with George Hill on the team. I don't think he'll start over Paul George so unless he wants to come off the bench, he's or going to sign with the Pacers.
Ultimately, I think that's why B.Roy and Crawford passed on the Pacers. They want to go somewhere they can have a chance to start. My guess is that Mayo will sign with Dallas or Phoenix where he can play plenty of minutes.
A LOT of teams do this. So it shouldnt be seen as a knock on Mayo. Whether he starts or not, I bet he finshes most games.
This. And it's not going to hurt Paul to have competition for his starting job. Some nights he just plain stinks. Maybe it would light a fire under him.
82games.com keeps track of what percentage of each position's available minutes that individual players use. Basically, each position has 3,936 available minutes in an 82-game schedule, so, for example, if a player plays 394 minutes at center, he'll be listed as taking up 10% of his team's center minutes.
Anyway, according to their numbers, Mayo's never played a significant number of minutes at point guard. The most time he's spent there was about 7.2 mpg in the 2010-11 season. The results look pretty bad.
Here are the links, for anyone who cares: 08-09 | 09-10 | 10-11 | 11-12
Jon Krawzynski: APNewsBreak: Timberwolves agree to terms with Batum on 4-year, $45M offer sheet with bonuses that can push it past $50M. Batum wants MN. Twitter
Garbage players get 1st round picks, (WTF)! All of the NBA must hate the Pacers! LOL
Adrian Wojnarowski (WojYahooNBA) on Twitter
If I'm Portland, I take a look at that. I don't think I would outright reject it. You're talking a player who can start at the 3 and back up the 4. That can be useful.
Wonder what Portland has pitched Pacers for Hibbert...
Garbage players get 1st round picks, (WTF)! All of the NBA must hate the Pacers! LOL
I would counter it with DWill and Pekovic....Webster is terrible!
Garbage players get 1st round picks, (WTF)! All of the NBA must hate the Pacers! LOL
You aren't kidding. He is something else. I was just going off of Williams potential.
Grizzlies and Marreese Speights Reach Agreement on Two-Year Deal | Beyond the Arc
Originally Posted by Chris Herrington
Oh man. Watch us make an overpaid bid for OJ freaking Mayo.
I've been the one preaching "wait for July 11 before freaking out", but I seriously don't like the trend of Mike Wells' tweets. I don't think much of Wells' opinion/insights, but his inside info has proven to be accurate in the past.
We're going to let Roy walk, give Mayo 7+ million a year and chase Kaman's old no defense empty stat sheet *** for 8 figures. And Walsh and Pritchard shouldn't stomp on that flaming bag on their porch.
True, this franchise could be in for another disastrous season full of mediocrity if Roy is not re-signed. Wells doesn't make things sound very promising either. I think getting Mayo for the right price is a good move for the team, not re-signing Roy could hurt our fan base a lot.
Sorry, but I've never seen much about Mayo that says great shot creation or point guard skills. He seems to me to be similar to Hill, George and Granger: Good shooter, can make some nice drives, but lacking in a creative midrange game.
There's nothing about adding Mayo that would help this team where it itches. I'd rather have taken Brandon Roy, who could be a real difference maker, and risk the 70 percent chance he'd be a flop.
My only hope now is Imawhat's comment that maybe this is setting us up to trade George or Granger or Hill for a truly helpful part.
"Look, it's up to me to put a team around ... Lance right now." Kevin Pritchard press conference
Mayo isn't a point guard. He'd sooner be a power forward.
It wasn't about being the team everyone loved, it was about beating the teams everyone else loved.
Division Champions 1955, 1956, 1988, 1989, 1990, 2002, 2003, 2005, 2006, 2007, 2008
Conference Champions 1955, 1956, 1988, 2005
NBA Champions 1989, 1990, 2004
The story goes that Mayo's people kept yammering about how OJ should be playing point guard. So then one summer league, Memphis said okay, come to summer league and play the point guard position, mostly to shut up his "people". He did and was horrific at it by multiple reports. This was the story at the time, I have no idea how true it is.
I think OJ would be happy to have the ball in his hands, which if he's a guy who would fill Barbosa's role, he would be, here.
Last edited by Speed; 07-06-2012 at 07:48 AM.


text:
Root Beer Kit
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This item is currently not available.
Additional Information
Make Delicious Homemade Root Beer
- Brew delicious root beer in just three days
- Naturally carbonated for a smooth, refreshing flavor
- A fun project for the whole family
This home-brewed root beer is naturally carbonated, giving it less fizz and a smooth, creamy taste. With this kit you can brew two, one-gallon batches of creamy and delicious old-fashioned root beer. The kit includes all the essential ingredients plus four bottles and complete instructions.
Product Details
- Ingredients: root beer mix, dry yeast, flavor crystals (you provide sugar)
- Kit includes bottles and caps: four reusable plastic (PET) 1-liter bottles, labels, no-rinse cleanser and reusable plastic pressure relief caps


text:
Two new fan-favorite action films hit hi-def home video...
For a great selection of film, comic and TV action figures and collectibles, check out BigBadToyStore.com, BriansToys.com, ToyWiz.com, PastGenerationToys.com, MonkeyDepot.com, HobbyLinkJapan.com, and YesAnimation.com.
For a great selection of film, TV and pop culture t-shirts and apparel, check out TShirtGurus.com and 80sTees.com.
Walt Disney Studios Home Entertainment recently released two fan-favorite action films to hi-def home video: Tombstone and Armageddon. While both films come to life in beautiful 1080p and feature impressive sound, it's worth mentioning these releases could be better...which probably means there's plans for future releases of these same films in the works.
While not everyone likes westerns, there's nothing to not like about Tombstone. Directed by George P. Cosmatos (Rambo First Blood Part II, Cobra) and written by Kevin Jarre (Rambo First Blood Part II, Glory), Tombstone features one of the most impressive casts of any action film I've seen, including Kurt Russell, Val Kilmer, Michael Biehn, Powers Boothe, Bill Paxton and - one of my favorite actors - Sam Elliot. Likewise, there's even a cameo by the one and only Charlton Heston too!
Acting aside, Jarre's script is simply amazing and some of the most memorable one-liners in all of film history are said right here in Tombstone. With a great production value, an awesome cast, and an amazing script, it's a bit disappointing this hi-def release, which includes a decent 1080p video transfer and extremely impressive DTS-HD 5.1 Master Audio, it's unfortunate the real attraction of the 2002 DVD Vista Series release of Tombstone, which included a vast array of bonus features, isn't included here on blu-ray. The disc does offer the 3-part "making of" documentary, original storyboards, trailers, and TV spots, but the director's commentary, as well as the extremely informative and interesting interactive time line as well as the historical look at the actual shootout and events which took place at the O.K. Corral are no where to be found.
Overall, for fans who own the 2002 DVD release, the only major bonus in picking up the blu-ray is the solid audio and a slightly better picture quality. Unfortunately, the Vista Series DVD includes more bonus material. I'd guess there's a better version of Tombstone on blu-ray coming in the future, but - until then - this is it.
After he was John McClane but before he was Mr. Goodkat, Bruce Willis was a ragtag oil rigger by the name of Harry Stamper in a little old movie made by a then fairly popular action film director by the name of Michael Bay.
Now Harry was a man's man with a daughter who could date no one but A.J. Frost (played, of course, by Ben Affleck). And Harry, he took to the skies and saved the lives of not only his daughter and her love, but every man, woman and child on the face of the earth.
Now if that - set to an Aerosmith soundtrack - doesn't tug your heart strings, I don't know what will...
12 years ago, Armageddon hit theaters and, while some of it haven't watched it since the 1990s, many of us watched it more than once (or more than 10 times). It was, after all, the "save the world" film of the year, it stared John McClane (I mean Bruce Willis), and featured an awesome soundtrack (who doesn't like Aerosmith?). Likewise, it really was an action film. After all, it featured oil drills, astronauts, spaceships, explosions, and just enough romance to keep the women-folk happy.
Now, fans of this actioner can pick up Armageddon in hi-def. Featuring an impressive 1080p video transfer that'll have you staring into Liv Tyler's bold, beautiful eyes and an impressive DTS-HD Master Audio 5.1 surround audio track that'll ensure your living room rumbles with every explosion, this is truly a solid film worth watching in hi-def.
That said, there aren't a lot of bonus features here. In fact, the only thing this disc includes is the music video for Aerosmith's "I Don't Want to Miss a Thing" and a theatrical and teaser trailer. Yup, that's it.
While it might not include a commentary, behind-the-scenes documentaries, or even cast interviews, Armageddon does include one heck of a roller coaster ride of a action movie that will blow your socks off...or at least make you remember when, 12 years ago, you felt like your socks were blown off...
Both Tombstone and Armageddon are available now on blu-ray hi-def wherever fine home video is sold.
- Jess C. Horsley


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Company comes out with guns blazing...
San Diego Comic-Con coverage brought to you by Collectibles Insurance, Big Bad Toy Store, Sekaido, and Monkey Depot.
TriForce made their first Comic-Con appearance with guns blazing, showcasing their awesome arsenal of Gears of War weapon prop replicas and character sculptures. TriForce's long anticipated 1:1 scale Lancer, the iconic chainsaw bayonetted weapon of the game, was front and center at the show, TriForce opening up orders for the massive (and heavy!) 40-inch long weapon. The incredible gun is shipping now priced at $949.99 and limited to only 500 pieces. Lock 'n load with your own at projecttriforce.com.
Speaking of Lancers, TriForce had on display a unique, one-of-a-kind "Deadly Cute" version of the weapon. Designed specifically for Cliff Bleszinski's girlfriend, the blinged-out Lancer featured an attractive pink color scheme and fake rhinestone jewels on the saw teeth. EPIC and TriForce are looking at auctioning off the artistic piece to raise money for breast cancer awareness.
Another show-stopper was TriForce's Marcus Fenix Epic Scale Bust, a statue that is indeed... epic. Measuring an impressive 32 inches in height, the bust awed fans with its size and hyper realistic sculpt. Two versions of the light-up bust were offered to Comic-Con attendees: Marcus clutching a standard Lancer (500 pieces) and one armed with an eye-catching Gold Lancer (only 100 pieces). Sales of both models were brisk with the Gold Lancer edition nearly selling-out. Grab one while you can at projecttriforce.com.
Gears of War product reveals came in the form of the Snub Pistol, the standard issue sidearm of the COG military. A cool prototype of the weapon was on display, pictured above in the hands of Drew Seldin, Vice President of TriForce. Pre-orders for this Gears' gun are expected this Fall priced at around $250 with the Snub shipping 1st quarter 2011. News at the Comic-Con Gears of War panel revealed that Triforce is also at work on an Epic Scale Augustus Cole and Lambent Berserker busts.
CLICK HERE for a TriForce Gears of War Comic-Con photo gallery tour!


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Blister better, Nelson slated to start on Tuesday
ST. LOUIS -- Scratched from Saturday's start because of a blister on his right index finger, right-hander Jimmy Nelson won't have to wait long to get back on the mound, as the team believes he'll be ready to pitch against the Giants on Tuesday at Miller Park.
The timing of Nelson's minor setback worked out for the Brewers. It came during a three-game series sandwiched between a pair of off-days, allowing for some easy rotation shuffling, and it also gave the Brewers a way to split up Nelson and Wily Peralta, something manager Ron Roenicke and pitching coach Rick Kranitz were already mulling.
Both are right-handers with similar stuff, including a power sinker.
"When this came along, it just allowed us to do this real cleanly," Roenicke said.
Nelson developed the blister during his Sunday start against the Mets, a 2-0 loss at Miller Park. The skin tore away during a long-toss session earlier this week in St. Petersburg, prompting the Brewers to make some changes. Kyle Lohse and Matt Garza each moved up a day but were still set to work on regular rest.
Nelson will attempt a light bullpen session on Sunday to confirm his availability for Tuesday. If he does have a setback, Yovani Gallardo would move up a day.
Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. This story was not subject to the approval of Major League Baseball or its clubs.


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Short-covering may be supporting the crop markets. The monthly USDA WASDE report is due out tomorrow (6/11), which could greatly affect markets upon its release. Given the size of the decline suffered lately, it's not terribly surprising to see old crop corn leading the way higher last night. The weekly Crop Progress report looked rather negative for new-crop corn, since the corn crop is looking very good at this point. July corn rose 3.0 cents to $4.54/bushel Monday night, while December added 2.0 cents to $4.52.
Chinese news may be supporting old crop bean and meal prices. The Crop Progress showed soybean plantings well ahead of normal and early conditions looking outstanding, which is weighing on new-crop prices. However, an overnight report indicating the latest Chinese government sale of stockpiled beans went poorly due to quality issues; that suggests they'll be forced to continue actively importing soy and products. Asian palm weakness is once again weighing on oil. July soybeans rallied 7.0 cents to $14.64/bushel early Tuesday morning, while July soyoil sank 0.30 cents to 38.98 cents/pound, and July soymeal bounced $3.3 to $485.5/ton.
The Crop Progress seemingly did little for the wheat markets. The weekly USDA report indicated that spring wheat planting are virtually complete, with the first condition rating of the year coming in only slightly below the long-term average. That appeared to undercut Minneapolis prices somewhat. Winter wheat ratings were unchanged once again. We suspect any pressure being generated by improved harvest prospects were more than offset by short-covering ahead of tomorrow's big report. July CBOT wheat futures edged up 1.25 cents to $6.1375/bushel in early Tuesday action, while July KCBT wheat stalled at $7.3375 and July MWE futures slid 0.5 cent to $7.04.
Cattle futures are taking a break after their recent surge. Although seasonal weakness is the norm for cash cattle prices at this time of year, cash and wholesale beef prices have proven quite strong lately. That powered the recent CME advance. It now looks as if bulls are taking some profits, with the looming WASDE report likely being an excuse for doing so. August cattle futures dipped 0.35 cents to 142.92 cents/pound as Tuesday dawned over Chicago, while December slumped 0.32 cents to 148.27. Meanwhile, August feeder cattle inched up 0.05 cents to 203.57 and October added 0.15 to 203.97.
Hog futures followed through on Monday's rally. Hog futures followed the cattle market higher Monday, due in part to spillover strength. Still, hog traders expect much more of the same, particularly with most-active August breaking out to fresh highs. Cash prices jumped yesterday, but pork quotes were stated mixed-higher. August hog futures advanced 0.40 cents to 130.50 cents/pound early Tuesday morning, while December climbed 0.17 cents to 95.27.
Cotton futures are trading mixed on Tuesday morning. The weekly Crop Progress indicated that southern Plains planting surged last week, with condition ratings coming in close to normal. That news weighed upon new crop prices, but old-crop July inched upward. Again, that looks like short-covering ahead of tomorrow's WASDE report. July cotton gained 0.09 cents to 84.64 cents/pound shortly after sunrise Tuesday, while December cotton sagged 0.12 to 77.17.


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The Fresh Produce Association of the Americas has elected board members and named a member of the year.
Jaime Chamberlain, president of Nogales, Ariz.-based J-C Distributing Inc., received the association's Member of the Year award at its annual membership meeting May 7 in Nogales, largely for his advocacy for Mexican tomato growers during their dispute with Florida growers over price floors, according to an FPAA news release.
"During the tomato conflict, Jaime Chamberlain stepped up to the plate numerous times for media requests," Lance Jungmeyer, FPAA's president, said in the release. "He was featured on NPR, Arizona television stations and major national newspapers. He helped bring home the impact on U.S. business during this very important debate on trade."
On the FPAA board, Alejandro Canelos of Nogales-based Apache Produce Imports will be chairman for one more year. SunFed's Matt Mandel will be chairman-elect until taking over as chairman in 2014.
Also at the May 7 meeting, seven distributor directors and two associate directors were elected to the board, and a new FPAA tomato division chairman was named.
Gonzalo Avila, Walter Ram, Brent Harrison and Scott Vandervoet were re-elected to two-year terms.
Chris Ciruli, Atanasio Panousopoulos and JJ Badillo were elected to new two-year terms.
Sabrina Hallman was re-elected to a one year term as an associate member director, and Rosie Cornelius was newly elected for a one-year term as an associate member director.
Badillo was elected chairman of the tomato division.


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Search Jim Cramer's "Mad Money" trading recommendations using our exclusive "Mad Money" Stock Screener.
NEW YORK ( TheStreet) -- If a company's fundamentals are declining, don't think they can be turned around easily, Jim Cramer said on "Mad Money" Tuesday. He reminded investors one of the time-honored investing mistakes and the biggest personal portfolio management errors they can make is to believe in a turnaround or takeover. Case in point, Hewlett-Packard ( HPQ) and Best Buy ( BBY), two stocks that were down 11% and 13%, respectively. Cramer said investors may be tempted to buy into these companies because they're both household names. Surely they'll be able to resurrect themselves, many may think, but in reality both stocks are total disasters. Tuesday, HP announced a $5.5 billion write-down for its purchase last year of the U.K.-based Autonomy. According to the company there was widespread accounting errors and misrepresentations at Autonomy, which caused HP to lose nearly $8.8 billion of its $11 billion investment. Cramer said the problem with HP is it's no longer an innovator but an assembler of products that are in decline. PCs are losing out to tablets while margins are shrinking in the printer business. Meanwhile, rivals are eating HP's lunch in the consulting business. Cramer said it's not too late to sell this stock, which has already lost 55% of its value this year. Then there's Best Buy, which reported more disappointing results Tuesday and continues to hope that someone, perhaps its founder, will swoop in and take over the company. Cramer reminded investors the tech world is littered with turnarounds and takeovers that never happened. Remember Circuit City? How about Radio Shack ( RSH)? That company is on death's door. Cramer said the list of tech stocks that are hoping for a turn is a long one that includes Nokia ( NOK), Research In Motion ( RIMM), Dell ( DELL) and even Microsoft ( MSFT). In all of these cases the fundamentals are in decline and management may be able to do little to stem the losses.


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BROOKLYN, NY - When the conversation is about which High School basketball teams are capable of winning the PSAL city title comes up, you always hear about NYCHoops.net #1 ranked Lincoln and #3 ranked Boys & Girls.
Other times you might hear that #9 ranked South Shore has a lot of talent, but something was missing. People aren't sure they can actually win the championship.
However, after Boys & Girls left the South Shore floor on the wrong side of the score at the end of yesterday's game, maybe more people will begin to believe that they can.
From the very beginning, South Shore appeared to have a lot of confidence. They were at home, and they were strengthened by their two losses to good teams last week. They knew that they would have to play hard and they accomplished that against the two time defending champs.
Mike Beckles, South Shore's head coach explained why his team's 61-58 victory was a big one.
"This win was important for us. We lost two big games in the league which I know we were capable of winning, and we showed that we can play with the better teams today" Beckles said.
Because of losses to Jefferson and then Lincoln, Beckles knew his team would have to play better and with more intensity. Shamiek Sheppard, a 6-4 junior wing echoed his coach and said that the Vikings picked up the defensive pressure and played hard and that enabled them to beat Boys.
The game was a good one and close throughout. Neither team led by more than six points, and that was late in the first quarter after Sheppard went up strong inside and put the Vikings up 18-12.
The game was a nice little showcase for Sheppard and Boys & Girls Leroy Fludd in the first half. Sheppard had scored 10 points in the half, while Fludd led all scorers with 14. Boys held a 31-30 lead at the break. When the third quarter began, that was when Terrence Samuel came to life.
Samuel didn't have a very good first half. He was turning the ball over a lot; sometimes he struggled with his dribble and just gave it up with no pressure a couple of times. He said he couldn't see the lane in the first half, but things opened up in the second and he started to be more aggressive and just took it.
He started with a pass to Sheppard who promptly dunked it. After Joel Angus picked up his third foul on a charge call and had to sit down, Samuel knocked down a baseline jumper and that was the start of him scoring 8 points in the quarter. A pull-up jumper by the 6-4 junior guard at the left elbow put South Shore up 42-38.
The fourth quarter was played just as tightly as the first three. The game was tied at 52 with just over 2 minutes left in the game when Sheppard, who finished with 17 points, split a pair of free throws to give South Shore a one point lead. Fludd answered with a put back to give his team the lead with 1:40 left, but South Shore knocked down 8 straight free throws to keep the lead and come away with the win. Sheppard, who sometimes struggles at the line, was swishing them from the charity stripe at the end.
"Going to the free throw line we got to have confidence. You just got to know you going to make it" Sheppard said.
It was a good win for South Shore, one they believe is a statement. They were excited after the game because they showed that they can play with the best. Samuel, who scored a team high 18 points, was asked how he feels when people talk about Lincoln and Boys and don't mention South Shore.
"I never really listen" Samuel said after coming out of the locker room. "We know we can beat them as long as we play our game. We're going to earn our respect…sooner or later"
Boys High was previously undefeated, but after the loss their record is 6-1. Head coach Ruth Lovelace said that the defense is normally there for them if they are struggling to score, but it wasn't as trustworthy against South Shore. She also felt her team got outrebounded.
"We just didn't do some things that we had to do" when asked why her team lost the game. Lovelace did try to find a silver lining in the defeat. "You rather lose now, because in the end it's probably better to lose early".
Fludd would finish with a game high 31 points. He was basically the only Kangaroo who was able to score consistently. Was it part of the game plan to let him score and shut down everybody else?
The common answer was no, South Shore definitely tried to stop Fludd too. It didn't really work out that way because he is good. He is showing that he is one of the best players in the city.
But the team that was the best, even if it's just for this game, was South Shore. In their minds, they need to continue to play hard. If they do that, they can come away with the title. South Shore players truly believe that.
Click Here to view this Link.


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That is why we think that many of Dan Pallotta's arguments are extreme and "dead wrong." I have more detailed explanations of my many disagreements with him here, here, here and here. Specifically on the issue of overhead, show me a nonprofit that uses 70% of its funds for overhead and I predict with a great deal of certainty that it is an organization that is either clueless or focused on lining someone's pockets rather than effectively serving others. People may disagree on what the best metric of overhead should be, but to say overhead is irrelevant is to deny a useful indicator of where many thieves and scoundrels dwell. I have worked in enough nonprofits with unethical leaders to say without question that we need to get serious about their existence as more than a rarity (see the book Silence, by Gary Snyder). As noted above, this is not meant to imply in any way that overhead is the only metric donors should consider, but rather that it is an important data point.
This is exactly why, for a number of years now, we have been working towards a three dimensional rating system (which we now call CN 3.0). Specifically, we believe the three dimensions that must be considered for a social investor to have the critical information needed to make a wise decision are the charity's:
- Financial Health (CN 1.0 launched April 2002) – Is the nonprofit sustainable? Does it have robust financial strength to survive in good times and bad? Is the overhead not at the extreme end of the continuum?
- Accountability & Transparency (CN 2.0 launched September 2011) – Does the organization have ethical practices, good governance and transparency? Is it accountable to its constituents?
- Results Reporting (CN 3.0 methodology launched January 2013) – Can the organization supply information about meaningful and lasting change in the communities and lives of the people it serves? Can they show evidence that these changes are as a result of their efforts? Do they have systems and processes in place to effectively manage their performance?
I believe that this is a critical battle for the very soul of the nonprofit sector. We MUST get past the notion that overhead is all that matters, while recognizing that efficiency and financial health is of critical importance in maintaining high performance and the best results for the long term. We MUST get past the notion of doing the "good work" with no accountability and transparency, because we know that charities without strong governance and ethical best practices are far more likely to have leadership problems. Once again, to maintain effective results we have to have these characteristics and policies in place. Finally, we MUST get past the idea that nonprofits are too complex or unique to be measured. I have seen it close up for years and it is not a pretty picture. The nonprofit sector must get its act together and make sure it is really helping provide meaningful and lasting change. It is life or death for many of those we serve whether charities are efficient, accountable, transparent and effective or not.


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While conducting a probation search, Yolo County Sheriff's deputies shot two pit bulls that charged the deputies. The pit bulls were shot and killed.
The incident occurred at 9:20 a.m., Monday when several deputies conducted a probation search at 138 Antelope St., in Woodland.
Inside the residence they located two subjects, 46-year-old Carol Vitalie, and 43-year-old Vincent Van Asperson, along with three pit bull dogs. The three pit bull dogs were in a bedroom that needed to be searched. Yolo County Animal Control Officers responded to remove the dogs from the bedroom.
"While one dog was being removed by an animal control officer, a second came charging out of the bedroom and a deputy Tased that pit bull," according to Sgt. Lance Faille of the Yolo County Sheriff's Department. "A third pit bull came out of the bedroom tearing the electrical wires from the Taser's barbs.
"Both loose pit bulls charged two different deputies in separate locations of the residence and were shot by those deputies," using their sidearms. "The pit bulls were transported to UC Davis Animal Hospital and were deceased on arrival. The third pit bull was removed from the residence as well as five other dogs that were in the back yard, they are currently at the Yolo County Animal Shelter." None of the dogs were properly licensed, according to Faille.
Vitalie and Van Asperson were arrested for possession of drug paraphernalia and booked at the Monroe Detention Center.
The subject of the search, Shane Edgington, was not located at the residence at the time of the search. The specific reason deputies were conducting their probation search for Edgington was not provided.
It is also unknown if Woodland police were notified of the search.


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Tag: Summerslam
- On Saturday July 26th North American Fighting Championship once again put on an incredible fight card at The Rave Eagles Grand Ballroom. Fans from Milwaukee and surrounding areas packed the house to watch the top up and coming young MMA prospects showcase their skills for NAFC "Summer Slam". The team of Combat Corner fighters on


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Rebel with a cause
Whether a fan of the TV show or not, Pee Wee Herman's big screen adventures were always more fun and endearing. In Pee Wee's Big Adventure, he goes on the hunt for his stolen new bike which turns into cross-country endeavor. As he tracks his bike down, stolen by his arch nemesis Francis Buxton, Herman doesn't only strive to reclaim his bike, but he helps audiences reclaim a sense of childlike wonder, trust and excitement. Watch it in its glorified 35 mm print.
DEETS: Texas Theatre, 231 W. Jefferson Blvd. 7:15 p.m. $9. TheTexasTheatre.com.


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By APCNews NEW HAVEN, 16 February 2010More than 20% of human genes are patented in the US which, among other things, is preventing people from accessing affordable and appropriate testing and diagnoses of genetic diseases. This is only one example of how restrictive intellectual property legislation is impacting human rights. At the Yale Information Society Project's conference, of which APC was an organising partner, these issues, which also include the impact on innovation, scientific research, freedom of expression online and education were discussed by civil society and adademia. Watch some video interviews. More info on the conference, including blogposts, video streaming and pictures at the: Yale's ISP page
Interview with Esther Wojcicki at A2K4 from APC on Vimeo.
Inverview with Rolando Lemos at A2K4 from APC on Vimeo.
Natasha Primo from Jason Eiseman on Vimeo.
Anupam Chander from Jason Eiseman on Vimeo.


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You are hereKids-Tech 8/4 - 8/6
Kids-Tech 8/4 - 8/6
*canceled - please sign up for one of the other dates *
THS Kids-tech is a summer camp for kids aged 12 to 16.
Kids will learn the basics of electronics through hands on projects that teach them about components, reading schematics, and building circuits.
Several projects are planned.
Kids will build and take home:
* their basic electronics kit
* EL wire flower night light
* Bug bot
* LED flash circuit
Additional projects may be planned.
Lunches are provided by catering service!
* Please notify us if your child has any special dietary needs *
All activities conducted in English. International students are welcome, but must be able to understand and follow basic instructions in English.
When: August 4th - 6th, 10 a.m. to 4 p.m.
Where: Tokyo Hacker-Space near shirokanedai
How much: 35,000 yen
*10,000 yen Deposit requested (subtracted from the total tuition fee)
*Please fill out the reservation form completely and accurately. If you are un-reachable via email or phone, your reservation will be canceled.


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Let's trade Hibbert while his value is high!
(Maybe he will hear about this thread and tear it up like Paul George did last night!)
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Let's trade Hibbert while his value is high!
(Maybe he will hear about this thread and tear it up like Paul George did last night!)
If Roy stinks it up next game we can all blame you guys for not rollin' with it!
He needs to add a good 30 pounds of muscle and he'll becomes a top center.
I hope you realize how difficult it is to find solid centers in this league. Especially ones over 7 feet.
Roy has added some muscle strength since his rookie year and it's helped him out a lot, but as a center, it would make him solid if he could add some more strength. Maybe not 30 pounds in a summer, but 20, like Josh wouldn't be bad.
I don't think it's 100% a mentality issue for Roy. I think it comes from other centers, with more strength overpowering him.
Hahaha he's being sarcastic guys..
Let's keep Hibbert.
I have an alternate trade idea. Let's trade troyc11a to the RealGM board for 2 trolls and a poster to be named later.
Of course, when you have a streak goin' you dont mess with it! Works one time = streak!
WOW, some people can't read.
Let's go see Sergio!
When I started reading this thread...
When I seen the O.P. was being "sarcastic"...
I really don't know what to say about this thread...
...Still "flying casual"
Wait, you know Sergio!?
I dont want to trade him unless we would get top dollar for him. Which wouldnt happen but I am opeing to trading all 15 guys if it makes our team better in the future..
Last edited by pacer4ever; 04-08-2011 at 02:09 AM.
Trade Hibbert???? WTF
This isn't worthy of a thread and since this one's sarcastic, let's get a little serious.
How about Terrence Williams this summer? Houston doesn't seem to have any interest in him other than to let him occupy a uniform, wouldn't think it'd take much to get him at all, maybe a couple 2nd rounders.
I agree with that. Nobody on a sub 500 team should be safe from a trade. Having said that, I think it's ok to have a little light hearted fun on this board. We dont always have to be so serious and argumentative. We are all Pacer fans who want to the team to suceed. I just thought it was funny how Paul George played his best game as a pro the day after being ripped on this board and discussed in possible trades. Being a former college athlete, I respect a streak! So c'mon Hibbert! Kick some but!


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Hey everyone, This is my first post so here goes.
I have only been playing around 2 months, but it has become a huge addiction. My question is this: What is the max legal weight for discs? From what I read on PDGA it looks like 200g. The reason I ask is I have a 180g super roc, and a 180g star sidewinder, but I have heard these are not legal to use. Any insight would be great. Oh, and love the site Blake, it has helped me more than any other resource. Thanks!


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Is the Lithium Battery Ready for Electric Vehicles?
Is the Lithium Battery Ready for Electric Vehicles?
In our lithium work at TRU we have proactively studied and read many reports on the readiness of the lithium-ion battery for HEV and EV. Most expert opinion says that in about five years 2013 the technology will be ready and as a result the electric vehicle market will take-off like the proverbial hockey-stick. Yet none of these experts can explain succinctly why they expect this breakthrough to occur. If you have the explanation we would like to have it and I am sure the readers of this forum will too!
Also if you are a company developing lithium batteries for electric vehicles please contact us at TRU urgently. We are engaged now - January 2008 - in developing a long range 2020 forecast of the lithium market and could include your company in our technical review of electric vehicle battery technology.
Please contact me through this forum or visit our website trugroup.com.
he link to the TRU Group Inc lithium page is


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Sign into our member site to view your information online.Forget your username or password? Not registered? Register here
amoxicillin (generic name)
Dispermox (brand name)
It is used to treat certain kinds of bacterial infections
(a mox i SIL in)
Table of Contents
Top Learning Centers(Recursos en Español)
What is this medicine?AMOXICILLIN (a mox i SIL in) is a penicillin antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
How should I use this medicine?Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Use a specially marked spoon or dropper to measure every dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. This medicine can be taken with or without food. It can be mixed with a small amount of infant formula, milk, fruit juice, water, or other cold beverage. The mixture should be taken immediately. Take your medicine at regular intervals. Do not take your medicine more often than directed. Finished the full course prescribed by your doctor even if you think your condition is better. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. There should be an interval of at least 6 to 8 hours between doses.
What may interact with this medicine?
What should I watch for while using this medicine?Tell your doctor or health care professional if your symptoms do not improve in 2 or 3 days.
If you are diabetic, you may get a false positive result for sugar in your urine with certain brands of urine tests. Check with your doctor.
Do not treat diarrhea with over-the-counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if the diarrhea is severe and watery.
What side effects may I notice from receiving this medicine?Side effects that you should report to your doctor or health care professional as soon as possible:
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Where should I keep my medicine?Keep out of the reach of children.
After this medicine is mixed by your pharmacist, it is best to store it in a refrigerator. However, it can be kept at room temperature. Throw away unused medicine after 14 days. Do not freeze.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


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AIDS Interfaith Network announced three events in two weeks to benefit homeless and low-income clients of the agency.
"We really do have opportunities for everyone to support AIN," writes Travis Gasper, AIN's director of development. "From trying your hand with lady luck, to simply going out to dinner, you can impact someone's life and support AIN. Every dollar makes a difference!"
Among the services AIN provides are transportation, adult day care, meals, pastoral services and translation.
The upcoming fundraising events are:
• Chili's Give Back Day, Thursday, Feb. 23, 11 a.m. to 10 p.m, 3230 Knox St. in Dallas: Enjoy lunch, dinner, take-out or catering from Chili's, and a portion of all sales go back to AIN. AIN Ambassadors will be at the restaurant all day; just stop by get a flier to present to your server. Let Chili's do the cooking, and support AIN at the same time. Call 214-801-8006 for catering info.
• Charity Poker Tournament, Saturday, Feb. 25, 3 p.m. at the Brick, 2525 Wycliff Ave.: Feeling lucky? Play Texas Hold 'em Poker in our monthly tournament, in partnership with Pocket Rockets Dallas and the Dallas Bears. You don't have to be a card shark to try your luck. Free to join, with great raffle prizes and drink specials all afternoon. Click here for more information.
• Making One Meal Matter, Tuesday, Feb. 28, 6–9 p.m. at Bread Winners in Uptown, 3301 McKinney Ave.: Dine out and make a difference! Bread Winners will donate 20 percent of your bill (including beverages!) back to AIN. An easy way to fill up and do good. Call 214-754-4940 for reservations.


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At our first scientific conference for the non-scientist over 100 attendees learned about the latest scientific advances, how novel research is improving care, and the critical role patients play in making new treatments possible. Speakers included scientists working on basic and clinical research as well as passionate advocates committed to overcoming the many legislative and healthcare insurance challenges to improved treatment.
President and CEO of the Lupus Research Institute Margaret Dowd opened the conference with a comment she called irreverent. "New drugs don't come from the tooth fairy. They have to come from research and from the science." LRI Board member Hope Hetherington gave an overview of the discoveries funded by the Institute followed by presentations by four world-renowned scientists on what they are researching right now that may significantly impact patient care. Lupus patient and advocate Kathleen Arntsen, president of the Lupus Foundation of Mid and Northern New York, Inc. covered the many issues impacting healthcare and how patients can help effect change so research advances can directly benefit their lives.
Novel Research = Better Treatment: An Overview of LRI Contributions
Our own Board member Hope Hetherington spoke eloquently about why research is so important and how the LRI is succeeding in making possible discoveries that are changing how lupus is treated.
LRI novel research has uncovered new genes, molecules, and pathways that are now new targets for drug development. Hope pointed to two major complications of lupus where discoveries funded by the LRI are having an impact: heart and kidney damage. LRI research has led to new ways to identify and treat patients at risk of heart disease. And our discoveries on how lupus damages kidneys have provided new strategies for treatment; there are now over 30 trials looking at possible therapies.
"Deep understanding of the disease makes lupus drug development more attractive for investment by the pharmaceutical industry – an effect known as de-risking. Re-purposing of drugs has also generated important therapies for lupus."
New Treatments on the Horizon, Need Patients for Clinical Research
Dr. Richard Furie, North Shore-LIJ Health System in New York passionately talked about where we are and where we are going in the treatment of lupus, emphasizing the tremendous potential in new drug development. He described the drug development process from laboratory discovery through Phase III clinical trials testing safety and effectiveness of new drugs. "There are nearly 30 companies interested in developing drugs in lupus. But we need patients to participate to get these drugs tested and approved." Watch the full video of his presentation at the LRI conference to learn more about what is involved in clinical trials and how patients and their families can help bring forth new treatments.
From Our Researchers:
Putting the Brakes on
Researcher Dr. Carla Rothlin from Yale University shared her research on finding a way to regulate the immune response by comparing the immune system to a car. She talked about their work on finding a way to put the brakes on to keep the immune response in check. Read more about Dr. Rothlin's research findings and watch the full video of her presentation here.
Can a Food Supplement Prevent Blood Clots?
Dr. Bruce Furie, Beth Israel Deaconess Medical Center in Boston discussed his research into the possibility of using the food supplement rutin to prevent blood clots associated with lupus. His presentation included videos of the formation of a blood clot in real time taken using an incredibly innovative and sophisticated imaging technology he and his team developed to understand the clotting process. "We are currently testing this in mice with the goal of developing a novel, safe and effective therapy to prevent blood clotting in patients with lupus." Read more about Dr. Furie's research and watch the full video of his presentation at the LRI conference here.
Can HIV Drugs Treat Lupus?
University of California at San Francisco's Matthias Wabl, PhD, shared his work looking at whether the causes of non-Hodgkin's lymphoma and lupus might be similar and if so might be treated with anti-retroviral drugs like those used to treat HIV. Read more about Dr. Wabl's research and watch the full video of his presentation at the LRI conference here.
From Our Advocates:
Advocacy Needed so Patients Can Benefit from New Treatments
"What's the good of having new, targeted therapies if insurance companies won't let us take them?" posed Kathleen Arntsen, lupus patient, ardent advocate and president of the Lupus Foundation of Mid and Northern New York, Inc. Her presentation alerted attendees to the many legislative and insurance issues on the state and federal levels that threaten lupus access to quality patient care – issues that we call on our supporters for help in advocating for change.
From Our Patients:
How Research Impacts Living with Lupus:
"With the Lupus Research Institute, since lupus is such a difficult disease, instead of going back to the same types of research that people had been working on for years, we decided to think out of the box and try new things. The evidence shows we certainly chose the right path. The progress is increasing exponentially. The first new drug for lupus, Benlysta was 50 years in the waiting. That's a very good sign because now other pharma companies will then take up the cause of lupus knowing that a drug can be approved for lupus. I am very hopeful." Jennie, LRI Board Member, Lupus Patient and Advocate
"Research is important because it is our future. The hope is to find a cure, but meanwhile, we need to find new, better treatments." Julie, Lupus Patient and Advocate
"LRI researchers have discovered that in lupus patients HDL cholesterol that protects against heart disease, it's chemically altered to cause atherosclerosis. It's fascinating to me that my sister had heart disease along with lupus, and I know that I have high levels of HDL. So I ask myself, is that why she had heart disease and could this new research have helped her? That's very powerful. Hope, LRI Board Member and Lupus Advocate
"If I could take a test rather than a kidney biopsy that would be great... Having a kidney biopsy opens me up for infection, overnight hospitalization, blood clots. With all the research and new studies, it gives me hope that if I can't beat the disease, that at least I can lead a normal life…Learning about my disease, participating in research studies that is what is going to arm me against this war lupus." Olympia, Lupus Patient, Advocate and Educator
Why is Research So Important?
We asked patients and family members about their experiences with lupus and why they feel lupus research from the LRI is so important. Click here to view video interviews as they address these questions.


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We can be certain that Thursday will bring us an entire day of NBA -- Nothing but Apple (AAPL). But let's not blame it all on that stock.
You probably already know the list of the indicators. But, for a quick review, keep in mind the number of stocks making new highs has still not exceeded the September highs. Moreover, each subsequent higher high in the indices this year has coincided with a lower new-highs reading. That is a negative divergence.
The lower high in the Oscillator is a negative divergence, as well. So is the lower high in the Volume Indicator, and ditto for the failure of the KBW Bank Index or European shares to do anything much after the first few days of the year.
Sentiment-wise, the Investors Intelligence readings are above 50% for bullishness -- typically where we see a high in the market form. The moving average lines of the put-call ratio are all turning up, and the the ISE moving average line rolled over weeks ago -- both bearish signs. In addition, margin debt is high and complacency abounds.
While folks will be fussing over Apple, I am certain they will soon discover the head-and-shoulders top in the Nasdaq that I have shown a few times in the last six weeks. How soon do you think this pattern will get some airtime?
I would ask you not to blame Apple so much but, rather, to expand your world and note that the German Dax has underperformed the S&P 500 since the start of the year. In fact, the ratio has broken an uptrend line that has been in place since last summer, and it has done so decisively. You may think I am picking on the Dax, but the French Cac 40 isn't much better, and it might actually be somewhat worse. That index actually closed lower Wednesday than it did on the first trading day of the year -- yet no one is fretting over Europe anymore.
Then there are the banks and their underperformance. Everyone seems to love this sector at the moment, yet look at the ratio of the KBW Bank Index to the S&P. It hasn't broken down yet, but it is on the verge of this. With that in mind, please look on the left side of the chart and notice what happened when it broke to a lower low in the spring. If you are bullish, you want the banks to hold and perform better -- and, thus far, they have lagged.
Finally, let's discuss the McClellan Summation Index for the Nasdaq, since Apple is a substantial component of that index. As of Wednesday's close, a net differential of negative 700 million shares would halt the rise of the indicator -- and more than that would tilt it down. So keep that in mind if beloved Apple trades lower Thursday. In other words, with all this upside in the market, it won't take much to roll the indicator right over.
In Top Stocks, Helene puts her 20+ years of experience in technical analysis to work for you. Take advantage of Helene's time-proven approach and her action-oriented analysis of technical indicators. Try it now. Get a 14-Day Free Trial.


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November 8, 2002 See More
A melodrama about two gay men in Tokyo who are approached by a female friend who wants them to help her have a baby. Easygoing Naoya works in a pet store, socializes on the gay circuit and gets his share of sex without ties, but remains unfulfilled. His dissatisfaction is eased by the prospect of a relationship when he meets sweet-natured research engineer Katsuhiro, who keeps his sexuality hidden from family and colleagues, including a female co-worker with transparent romantic designs on him. Asako is a troubled young woman with a past history of psychiatric problems, abortions and casual sex. Deciding she wants a baby in her life, Asako identifies Katsuhiro as the ideal donor, basing her choice solely on the fatherly look in his eyes during a brief encounter at a restaurant. Katsuhiro discusses the parenthood option with Naoya, who dismisses the idea. When he learns that Katsuhiro and Asako have continued meeting, and that his lover is still reflecting on the woman's proposition, Naoya is threatened by the intrusion into their relationship.


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Cigar at the ready, CBS News Abnchor Dan Rather battles it out in the TV news wars.
(continued from page 5)
"I wasn't sure I'd be in it more than a year or two," Rather recounts, dressed in sneakers and a casual, semi-military khaki shirt, ready for anything except sitting down to anchor the "CBS Evening News." "I had a good job at '60 Minutes,' arguably the best job in television news. And while I can be dumb as dirt about a lot of things, I was at least smart enough to know that."
Rather's ascension to the anchor chair wasn't automatic; he not only had to overcome the general perception that no one could replace Walter Cronkite (who was anchor from 1963 to 1981), but he also had to get past his own doubts about the job.
"Everybody from childhood friends to blood kin said, 'Don't take it,'" Rather recalls, often lapsing into a near whisper, belying his legendary intensity. "I thought very seriously about not staying here, but once I decided to stay, my sense of it was as follows: 'Well, I like a challenge and this is a hell of a challenge. While it may be true that the first person after Cronkite is going to get blown out, I'd like to try to prove that isn't so.'"
Fifteen years in the anchor chair is testimony enough that Rather has proven his credentials. Rather has survived two changes in CBS ownership and won every accolade known in American journalism. Since 1961, his "been there" credits are a timeline of the stories that most journalists only dream about covering. Rather has seen firsthand the nation's and the world's most tragic and dramatic events, true turning points in U.S. history.
Talking about which story he considers his most important, Rather says, "It would be pretty hard not to say the [John] Kennedy assassination." He was the reporter who told CBS radio that the president was dead, and CBS beat other news organizations by more than 17 minutes. "I happen to believe it is an ongoing story," Rather continues. "The effects still resonate through this society.
"But it's hard not to say the civil rights movement, which was my first big assignment with CBS News. In fact, I got it practically the day I walked in the door. And how could I not say Vietnam? How could I not say Watergate? The only president in history who resigned the office. Not only did he resign it, but he resigned it as a quote 'unindicted co-conspirator' in a wide-ranging criminal conspiracy. You don't get many bigger stories than that."
Rather ranks the attempt on another president's life as one of the top stories CBS News has covered, though it is rarely mentioned. "I'll tell you one that fades into the mist--the day [in March 1981] President Reagan was shot and very nearly killed shortly after he came into the presidency and shortly after I came into this job," he says. "The Reagan people themselves said, and some of them wrote, that we were the best on that story. How soon we forget that onetime Reagan chief of staff and Treasury secretary [Donald T. Regan] wrote in his book that because of Rather they had their sets tuned elsewhere, but somebody came in and said CBS is the best on it and they clicked all their sets over to CBS and kept them there." What Regan actually wrote in his 1988 book, For the Record, was that although the White House televisions were tuned to ABC, "later in the day we were told that the coverage from CBS was better."
Or take the 1989 Chinese democracy demonstrations in Tiananmen Square, which, Rather says, was one of the biggest and best stories he has covered because so many people at CBS worked on it. That May 19, an extraordinary live CBS broadcast of the chaos was made possible because CBS News had gotten a "flyaway," a portable satellite station, into Beijing. The reporting was highlighted by Rather telling the United States what was going on, while at the same time negotiating with two Chinese bureaucrats sent to the Shangri-la Hotel with orders to shut down CBS' transmission. Rather and his team capitulated only when instructed to do so by Rather's superiors at CBS headquarters in New York.
Rather hasn't stopped getting the big stories. He was the first to interview Saddam Hussein in 1990 after Iraq invaded Kuwait, and in 1994 he interviewed Haiti's military ruler, Raoul Cedras, live in Port-au-Prince just after President Clinton's speech about invading Haiti if Cedras didn't leave. During that special "48 Hours," Cedras told Rather and the world he would never leave Haiti.
Whether he's covering a story such as last fall's Hurricane Opal (hanging on for dear life to a pole so he wouldn't blow away) or simply delivering probing questions to a reluctant interview subject, Rather remains the standard-bearer for what an anchor should be.
Bob Schieffer, a fellow Texan and CBS News' chief Washington correspondent, Saturday anchor and host of the Sunday morning show, "Face the Nation," confirms that Rather will use almost any reason to get out on a story. "Without being corny about this," Schieffer says, "he's a very brave guy. He's been willing to do whatever you needed to do and go wherever you needed to go to get the story over the years, whether it was Vietnam or Iraq or wherever."
Schieffer then begins to laugh. "These hurricanes--he likes no story better than a good storm. We always used to say Walter Cronkite's favorite story was a fire. Dan's the same way about weather. You get any wind above 30 miles an hour and Dan begins to think we may have a hurricane here. That's how he got his start." Rather caught the eye of CBS executives in 1961 when he fed coverage of Hurricane Carla to the network.
Covering hurricanes also gives Rather the opportunity to smoke cigars, difficult as that might be in high winds and torrential rain. "Let me say to you," Rather insists, "and I can bear witness, [it's] difficult, but not impossible."
Unless an exception to policy is made, a hurricane is about what it takes these days for Rather to smoke one of his Oscar No. 9s on the job. The cigars are close by in the office, stored in a box in the refrigerator along with sodas and water. But in a bow to office decorum, he doesn't smoke cigars there; Amy Bennett, Rather's assistant, says, "He holds on to them. I don't know if it's out of habit. I know that he doesn't light them in the office, but they're always around. Like, he'll have one in his hand or one in his mouth, but it's never lit or anything."
That wasn't the case years ago. "There was a time, I guess about the time I came to this job on the 'Evening News,' where if I had something to write that was more than a few seconds, I thought I could write better if I had a really nice cigar. At that time I probably smoked 14, 16 a week," Rather recalls, despite the fact that he is not immediately comfortable talking about cigars. "This is a very difficult conversation for me because [my wife] Jean Rather has been on me to stop smoking cigars entirely. Occasionally I'll have a celebration cigar. Usually now when I smoke cigars is when I'm fishing."
Rather tries to fish a lot. "I go as often as I can. I love to fish, but it depends on the run of news," he says. "But from the spring until about the middle of October, when I can get to my fishing camp, which is in the Catskills [in New York], I'll get up every weekend if I can. In Texas, where we fish mostly lakes for bass, I get there five or six times a year." He has a house on Lake Travis, near Austin. "Now, when winter descends, I try to get to the Keys as much as I can. I love it down there. I have fly-fished for redfish along the Texas coast, not very successfully. I grew up fishing. My father loved to fish and to hunt, and I think it traces back to that. It has gained in recent years, gained with things such as good cigars and good Bourbon," he adds with a smile.
Rather began smoking cigars at an early age in his native Texas, working with older men. "I started when I was 14. I worked with a brush-cutting crew. First of all, they smoked cigarettes and chewed tobacco, [but] I had in my mind that I wanted to be an athlete. At that time and place--the time was the 1940s and the place was Texas--if you were gonna play football you knew you couldn't smoke. But this brush-cutting crew, at night they would sit around after dinner and smoke cigarettes and one of them after dinner would have a cigar. I remember that he had a White Owl, which was later described to me as the sweepings from cigarette factory floors. I didn't want to smoke cigarettes, but I wanted to be one of the gang, so I smoked White Owls and Roi-Tans."
Rather, never one to sit around, also went honky-tonking. "Yes, and saw some pretty amazing things," he recalls. "But it was a different era...that's when I got onto cigars. Now, fortunately for me it was a short time. It was only the summer and I was gonna hold the line on cigarettes so cigars were all right. Didn't inhale--guess that has a bad connotation now. I got on that summer and I've smoked cigars ever since."
He mellows a bit and chuckles as he remembers how he unwittingly almost committed botanicide with a cigar he had received as a gift. "The year is 1957, possibly early 1958," he says, sounding like the start of a bad documentary. "I had just gotten married. We had gotten a plant, a very nice plant someone had given us for our apartment. And Jean, who's very good about plants, has a green thumb and kept this plant alive against all odds. It was an indoor plant. She was encouraging me not to smoke cigars in the house. She had no objection to me smoking cigars at that time and knew that I smoked cigars, but she was pregnant and preferred that I not smoke cigars in the house. I took a nice cigar [outside]; I can't remember what it was, but it was a far better cigar than I was accustomed to smoking.
"In those days I smoked 15-cent cigars," Rather continues. "This cigar was probably a dollar. Anyway, I didn't smoke it all the way down and said, 'Gosh, I'd hate to lose this thing,' so I put it out and I brought it back into the house and I thought, 'Well, where can I hide this where it won't attract any attention and I'll be able to pick him up again?' So I put him deep down at the base of this plant in a place where no one could see it. Already out.
"Weeks later, Jean says, 'You know, I just don't know what to do. The plant has been looking sickly for quite a little while.' And I remember almost choking, thinking, 'Damn, that cigar's stuck up in there and that's what might be wrong with that plant.' So, quietly, while she was preparing herself for bed, I slipped in there and extracted the cigar and did away with it. I actually threw it out the back door, and the next morning I retrieved it and hauled it away. And you know, the plant almost immediately started getting better."
"The only other cigar story I can think of," Rather says, pausing, though he will actually think of more later, "Fidel Castro had given me a cigar, and I brought it back hidden, which you had to do back then. In those days you did have to hide. I think he gave it to me in 1979. Fortunately for me, the people who were looking either didn't find it or found it and said, 'What the hell, let Dan have one good cigar.' It was one single cigar.
"Anyway, I had treasured that cigar [Rather referred to it in one of his books as a "big, obscene Cuban cigar"] and I thought to myself, 'I'll wait till some time when I really have a good occasion.' I took it with me when I went to Afghanistan and hauled it through Afghanistan, and there was a particular moment, well not to put too fine a point on it, it was a dangerous time. But I took it out after a meal and said, 'Who knows? I may not be here tomorrow to smoke this cigar. I think I'll smoke it tonight.' Unfortunately, the Mujahideen with whom we were traveling had light [as in illumination] discipline in effect and they reminded me of that. And so, having brought my wooden matches and the cigar out, I put it back in its case and took out my Red Man chewing tobacco. Of course, [the guerrilla fighters] were filled with guffaws and great laughter."
To his frustration, Rather's career has not just been about smoking cigars, covering wars and reporting great stories, but about surviving in the rough and tumble world of network news, and of avoiding the land mines associated with celebrity and power. He prefers the clarity of the risks inherent to reporting from places like Afghanistan where he traveled with the rebels: "You pretty much knew where the danger was and who the enemy was. In the badlands of big-time television news, you don't know who the enemy is, and that makes it more interesting--and in some ways more dangerous."
The way he does his job, Rather suggests, may explain the flak that seems to flow his way. "I want to do everything all the time," he says, lapsing into the lingo of radio news, the medium in which he began his career. "I'm all news, all the time. Tall tower, full power, we break in when the news breaks out."
He recognizes his style may attract heat. "That's the nature of being where I am. That's the result of being under the very large microscope. I understand that. I don't complain about it because it does go with the territory," he says, growing more thoughtful.
When he first got the anchor chair, Dan Rather did not sit. He sort of sat and he sort of stood, hanging his left hip on the anchor desk. That first night he was nearly shouting the introductions to Lesley Stahl at the White House and Phil Jones on Capitol Hill and was clearly nervous about filling Cronkite's shoes. Today, if you watch a tape of the inaugural "CBS Evening News with Dan Rather" and a lot of the ones that followed, you would not be surprised by what fright-meister novelist Stephen King once said of Rather: "I've got a sneaking admiration for Dan Rather because I'm never sure when he's going to go bonkers on you. He always looks like he's gonna just stop and say, 'All right, motherfuckers, here it comes. We've got the bodies in hangar 18, the government has been lying to you....' And then they're going to drag him off."
One reporter for a national newspaper always watches Rather instead of ABC's Peter Jennings or NBC's Tom Brokaw because he is convinced that "one day Dan's just going to spontaneously combust on the air, and I don't want to miss it."
"The core of it is," says Rather, "for better or for worse--and you could argue this a lot of different ways, I guess--is that I have tried to remain a working, cutting-edge journalist and I don't do it the way everybody else does it. And I think that's the difference."
The core of Rather's problem is simple to understand: He is one of the most competitive people in the world. "He loves news too much," says Tom Bettag, a longtime producer for Rather at CBS News and now the executive producer of ABC's "Nightline." "He pours himself so much into news that it is such a huge part of his life. I mean, he is a great family man, but that's all there is in his life: news and family. [Rather and Jean have two grown children--a daughter, Robin, and a son, Danjack.] For his sake, you'd love to have him have more time for other things. I think that's a real fault. It is an imbalance. Generally, people who are really great at what they do, do it because they're really fanatical about it; Dan is fanatical about news."
Rather is a hot magnet in a cool medium. "There is something about Dan, I don't know what it is, but he plays very big no matter what," Bettag says. "You can be in a place where a bunch of other anchors are gonna be, and when they walk in the room, some people will notice, some people won't notice, and then Dan will walk in the room and there's this electricity about the guy that people will say, 'Look, there's Dan Rather.' "
That kind of celebrity often throws everything out of proportion. The controversy around his dual anchor role with Connie Chung highlighted that reality. The Chung-Rather on-air dance is a painful episode in the annals of broadcast journalism, and the pain doesn't lessen in the retelling. Suffice it to say, as Marc Gunther succinctly wrote in his book, The House That Roone Built, "When Dan Rather's 'CBS Evening News' lost viewers, Connie Chung was named his congenial co-anchor and the broadcast took on the feel of local news, with cutesy features and reporters who strolled along as they did their closing stand-ups."
Rather is on the record in his 1994 book, The Camera Never Blinks Twice: The Further Adventures of a Television Journalist, as saying he supported the idea of co-anchors, and that it was a service to viewers. But he was wrong about the latter. The viewers, accustomed to the setup on their local news, simply didn't see it as much of a service on the national news. Finally, even the network realized the tandem anchor team was failing. "Clearly it wasn't working. Clearly they had to do something," says Schieffer, a close and longtime friend of Rather's. "They made the decision to go with Dan, and I happen to think it was the right decision. I don't mean to speak ill of Connie and I'm not trying to kick her while she's down, but it's certainly the decision that I would've made."
Chung, additionally slapped with the impending cancellation of her magazine show, "Eye to Eye," ended up leaving CBS altogether, even though she was offered another job there. At the time she said she declined a smaller role because it would have been "inappropriate for the only woman on the three major network news programs to have anything less than co-equal status." Although Rather insists he has made peace with Chung, criticism of him didn't end with her departure. Her agent, Alfred Geller, recently refused to comment about the entire affair, but stood by earlier comments made to The New York Times in which he essentially accused Rather of lying about his role in Chung's departure. Chung, for her part, was unavailable for comment.
"I've said before, I've said continuously and I say it now, I like Connie," Rather insists. "I bear her absolutely no ill will and I wish her the best," adding that he has done so many times in conversation and correspondence with Chung.
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… After our own fundraising festival in Indianapolis, I wrote that there just didn't seem to be a better event marketing platform on the market than Facebook. According to Maximillion, I was right! Love it or hate it we all now know social media is here to stay and is playing an increasing role in our daily lives. As well as individuals, business…


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What is a supervisory system?
Future of Supervisory Systems in Process Industries: Lessons for Discrete Manufacturing
By Ian Nimmo, President, User Centered Design Services.
What is a supervisory system?
Basic definition
The early 1970s were the commencement period for computer control. Memory and disk space was very limited, and the interface to the computer was very basic. The initial control was what we describe today as Supervisory control. The computer had limited output capability, but could influence instrumentation systems by changing the setpoint to PID electronic controllers.
During the startup phase of a continuous polymer process the characteristics of the polymer change. Based on plant throughput different process control setpoints require adjustment. In the old days the operator used to tweak the controller setpoint but would often over compensate and introduce new disturbances in the process. The early computers only changed the setpoints to these controllers but within a couple of years the mathematical model of the PID controller was developed within the computer program. This allowed not only automatic changes to the setpoint but changes to the tuning constants of the controllers also. This was very useful for non-linear processes.
However, the User Interface was still very crude and plant supervisors used to interface to the computer by identifying the address a variable and entering it through a set of 16 piano style keys, then entering new data points using the same keys. The process was very dangerous, especially when we consider that the data was not entered in normal base 10 numbering but base 8 octal or binary formats.
Soon more powerful monolithic control computers were introduced but were limited by small amounts of memory and often no disk storage capability. The Supervisory Control Computer System held the main program and instructions for the target control systems. The Supervisory system downloaded the latest software version to the control system and the supervisor initiated a booting or startup sequence. During the plant control the target system fed information about the process back to the supervisory computer system, including batch records, historical plant data and any abnormal condition reports.
The control system user interface improved slightly allowing operators to change the control computer setpoints and alarm values directly at the control computer system. This, however, required regular updates back to the Supervisory system to allow easy alignment should the computer shutdown and require reloading of the basic program. This meant that the Supervisory Control Computers required several versions of the plant software, the basic or virgin image, a sucked back copy which held the latest setpoints and other data parameters, and often development versions of the software which was either under test or being developed by a programmer.
The Supervisory system became a very powerful system especially on batch processes and as Digital Corporations VAX computers and commercial VMS operating system became available and cost effective, the use of off-the-shelf database products improved the historical data capture and replay capabilities.
As the Supervisory systems continued to evolve, Honeywell introduced a new more powerful Distributed Process Control Computer System (DCS) that could work independently of the Supervisory systems. They had good human interface, historical data capture and replay capabilities and powerful alarm management systems. The Supervisory Systems became a place to store large amounts of historical data and for the optimization or mathematical modeling environment.
Today, the DCS works independent of any supervisory system but has relinquished some responsibility for advanced control to more powerful supervisory systems, however, even this is changing due to the power of the new open system technologies being used for control. It is becoming difficult to tell were the control system starts and ends and if a separate supervisory system as we know it is required anymore.
The ICI Robot story
The development of more capable computers allowed mechanical systems, such as robots, to be used for many highly labor intensive activities that only needed muscle and little in the way of human skills. However, there are some lessons for us as we consider the introduction of this new technology. The robot was identified for repetitive tasks. Also people and robots never should work together. The robots were put into large safety cages and isolated from all contact with people.
I remember my first robotics application within Imperial Chemical Industries (ICI) in the UK. The company were keen to identify and use time saving and cost effective automation. A group of engineers with ideas for applications of this technology was formed and several trial applications were investigated. It became obvious that there were many reasons why people should not trust this technology. The British Government had identified high risks to people from the robots as they were very robust and could seriously hurt a person or even kill them should people get in the way of their movements. The answer was simple. Isolate the robots from people by placing them in high security prisons. Should a person need to enter the room where the robot was working, elaborate isolation equipment was employed to secure the robots. This made them expensive and no longer cost effective.
My first robot was no exception to this rule, I had the great idea to use my robot as a shrink wrapping system for 300Kg bales of staple fiber. The existing bales of what looked like very large cotton pillows were wrapped in polythene which needed to be shrunk by heating the polythene at very high temperatures. The existing system consisted of a large open electric oven with a conveyor through its middle. The conveyor carried the bale from the wrapper to the oven, to labeling and the warehouse for transportation to customer sites. The electric oven was very inefficient and was costing millions of dollars in energy usage, the wrapping was poor due to the large side ears that resulted because of the wrapping and shrinking process.
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Topic: How in the world do I get him to eat?
Hello Everyone! I am so glad to have Lee home now. They put in two titanium stents into the tree of his liver for drainage and except for alot of pain, he is home and enjoying it. However, food tastes "horrible" he says. He has lost almost 45 pounds since December. We are going to oncologists this Wednesday to discuss his surgery and treatments thereafter...I know they want to put some weight on him as I do....but he just can't tolerate the food....aside from making all his favorite meals...and telling him to just plug his nose...(haha)....it appears he is continuing to lose more....any ideas on getting the pounds back on or how to make eating more enjoyable?


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Headlines (News Releases)
Waterloo Lutheran Seminary
Waterloo Lutheran Seminarys Inshallah choir invites public to join them for Christmas Carols with a Global Twist
Communications, Public Affairs & Marketing
Dec 6/13| For Immediate Release
Debbie Lou Ludolph, Dean of Chapel
Lori Chalmers Morrison, Acting Director, Communications & Public Affairs
WATERLOO Inshallah, Waterloo Lutheran Seminary's 100-voice choir, will present a program of Christmas Carols with a Global Twist at the rotunda of Kitchener City Hall, Tuesday, Dec. 10 starting at 5 p.m. The community is invited to come join in the singing, share some hot cider provided by St. Peter's, St. Matthews and St. Mark's Lutheran churches, and bring a donation for the House of Friendship, a Kitchener downtown charitable organization.
Inshallah celebrates the diversity of Kitchener-Waterloo with Christmas songs from around the world, including Asia and the Middle East, Africa and Latin America. Director Debbie Lou Ludolph says it is a way to celebrate neighbours new and old in this region.
"Several of the carols focus on children," says Ludolph. "A beautiful carol from Brazil that remembers the children who live in the dumps in San Paulo sings 'Look in the face of children everywhere and see the child of God, the gift of love'; and a carol from New Zealand reminds us: 'Every child needs breadChristmas must be shared.'
Come and sing with us. Share Christmas by singing with your neighbours and stopping to celebrate the gift of community.
Waterloo Lutheran Seminary (WLS) is a federated college at Wilfrid Laurier University and a theological college of the Eastern Synod of the Evangelical Lutheran Church in Canada. Founded in 1911, WLS was a predecessor to both Wilfrid Laurier University and the University of Waterloo.
View all Waterloo Lutheran Seminary news
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Monday April 8, 2013 7:39 pm
SOL REPUBLIC Master Tracks over-ear headphones now available for $199
Posted by Andru Edwards - Categories: Accessories, Wearables, Music, Portable Audio / Video
Our friends over at SOL REPUBLIC have finally released a pair of over-ear headphones. Dubbed the Master Tracks, the over-ear cans feature the same nearly indestructible build (thanks to the FlexTech polymer material,) with interchangeable headbands and cables, allowing you to customize the look and colors of the headset. The company refers says that the X3 Sound Engine is exclusive to the Master Tracks line, and that's what drives the bass, clear highs, and provides vocal accuracy.
You can get a pair of Master Tracks in black, white, or metallic blue, with additional separate Ion Green, Progressive Purple, and Flouro Red headband colors. Grab a pair for $199 on Amazon.
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