text:
A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Blood Related Cancers
This study has been completed.
Novartis Pharmaceuticals
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
First received: May 2, 2005
Last updated: April 27, 2016
Last verified: April 2016
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this trial is to assess the efficacy, safety, tolerability, biologic activity, and pharmacokinetics of AMN107 in six groups of patients with one of the following conditions:
Relapsed/refractory Ph+ Acute lymphoblastic leukemia (ALL) (arm 1)
Group A - Imatinib failure only (arms 2, 3 and 4)
- imatinib-resistant or intolerant CML - Chronic Phase (CP)
- imatinib-resistant or intolerant CML - Accelerated Phase (AP)
- imatinib-resistant or intolerant CML - Blast Crisis (BC)
Group B - Imatinib and other TKI failure (arms 2, 3 and 4)
- imatinib-resistant or intolerant CML - Chronic Phase (CP)
- imatinib-resistant or intolerant CML - Accelerated Phase (AP)
- imatinib-resistant or intolerant CML - Blast Crisis (BC)
Hypereosinophilic syndrome/chronic eosinophilic leukemia (HES/CEL) (arm 5)
Systemic mastocytosis (Sm) (arm 6)
|Chronic Myelogenous Leukemia Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive) Hypereosinophilic Syndrome Systemic Mastocytosis
|Drug: Nilotinib
|Phase 1 Phase 2
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase IA/II Multicenter, Dose-escalation Study of Oral AMN107 on a Continuous Daily Dosing Schedule in Adult Patients With Imatinib-resistant/Intolerant CML in Chronic or Accelerated Phase or Blast Crisis, Relapsed/Refractory Ph+ ALL, and Other Hematologic Malignancies.
Resource links provided by NLM:
Genetics Home Reference related topics: PDGFRA-associated chronic eosinophilic leukemia PDGFRB-associated chronic eosinophilic leukemia chronic myeloid leukemia
MedlinePlus related topics: Leukemia
Drug Information available for: Nilotinib
Genetic and Rare Diseases Information Center resources: Myeloid Leukemia Chronic Myeloid Leukemia Acute Lymphoblastic Leukemia Mastocytosis Systemic Mastocytosis Hypereosinophilic Syndrome Lymphosarcoma Chronic Myeloproliferative DisordersU.S. FDA Resources
Further study details as provided by Novartis ( Novartis Pharmaceuticals ):
Primary Outcome Measures:
- • To determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of AMN107 as a single agent when administered as an oral once-daily and twice daily dose to adult patients with imatinib-resistant CML (phase l) [ Time Frame: study duration ]
- • To characterize the pharmacokinetic profile of AMN107 in serum and, where samples are available, in tumor cells and normal hematopoietic cells. (phase l) [ Time Frame: duration of study ]
- • To evaluate the efficacy and safety of AMN107 in patients with imatinib-resistant or intolerant CML-BC, imatinib-resistant or intolerant CML-AP and imatinib-resistant or intolerant CML-CP. (phase ll) [ Time Frame: duration of study ]
- • To evaluate safety and preliminary anticancer activity of AMN107 in relapsed/refractory patients with Ph+ ALL, HES/CEL and SM. (phase ll) [ Time Frame: duration of study ]
Secondary Outcome Measures:
- To assess changes during and after therapy in malignant cells taken from the bone marrow and/or blood.(phase ll) [ Time Frame: study duration ]
- To evaluate the population pharmacokinetics of AMN107 (all arms of the study) (phase ll) [ Time Frame: study duration ]
- To examine whether individual genetic variation in genes relating to drug metabolism, CML and the drug pathway confer differential response to AMN107 (phase ll) [ Time Frame: study duration ]
- To identify gene expression patterns in tumor cells that are associated with treatment response to AMN107 or that correlate with the severity or progression of CML. (phase ll) [ Time Frame: study duration ]
|Study Start Date:
|May 2004
|Study Completion Date:
|September 2012
|Primary Completion Date:
|September 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm 1
Relapsed / refractory Ph+ ALL patients
|Drug: Nilotinib
Experimental: Arm 2 - Group A and Group B
Imatinib-resistant / intolerant Ph+ CML-BC patients
|Drug: Nilotinib
Experimental: Arm 3 - Group A and Group
Imatinib-resistant / intolerant Ph+ CML-AP patients
|Drug: Nilotinib
Experimental: Arm 4 - Group A and Group B
Imatinib-resistant / intolerant Ph+ CML-CP patients
|Drug: Nilotinib
Experimental: Arm 5
Hypereosinophilic syndrome and chronic eosinophilic leukemia patients
|Drug: Nilotinib
Experimental: Arm 6
Systemic Mastocytosis patients
|Drug: Nilotinib
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Main inclusion criteria include:
- Patients with CML in blast crisis, CML in accelerated phase defined as never in blast crisis phase, or CML in chronic phase defined as never been in blast crisis phase or accelerated phase who have: *developed progressive disease during therapy with at least 600 mg of imatinib per day, -OR- *patients with CML on imatinib therapy, at any dose, developing progressive disease and the presence of a genetic mutation likely to result in imatinib resistance -OR- *have developed an intolerance to imatinib
- Relapsed or refractory Ph+ ALL
- Hypereosinophilic syndrome/chronic eosinophilic leukemia.
- Systemic mastocytosis who have a clinical indication for treatment.
- Prior imatinib therapy for patients with Ph+ ALL, HES/CEL and SM is permitted but is not required
- CML patients who have been treated with an investigational tyrosine kinase inhibitor who otherwise meet the definition of imatinib-resistance or intolerance are eligible
- Written informed consent prior to any study procedures being performed
Exclusion Criteria:
- Impaired cardiac function
- Patients with severe/chronic or uncontrolled medical conditions (including but not limited to diabetes, infections, GI impairment, CNS infiltration, liver and kidney disease)
- Prior and concomitant use of certain medications (including but not limited to warfarin, chemotherapy, hematopoietic colony-stimulating growth factors, medications that can affect electrocardiogram test results, other investigational drugs )
- Women who are pregnant or breastfeeding
- Patients with a history of another primary malignancy that is currently clinically significant or currently requires active intervention.
- Patients unwilling to comply with the protocol.
- Known diagnosis of human immunodeficiency virus (HIV) infection
Other protocol-defined inclusion/exclusion criteria may apply
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00109707
Show 101 Study Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00109707
Show 101 Study Locations
Sponsors and Collaborators
Novartis Pharmaceuticals
|Study Director:
|Novartis Pharmaceuticlas
|Novartis Pharmaceuticals
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
Visit NovartisClinicalTrials.com: Pre-qualify for a trial, and view a list of trials and participating study centers.
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Hochhaus A, Baccarani M, Giles FJ, le Coutre PD, Müller MC, Reiter A, Santanastasio H, Leung M, Novick S, Kantarjian HM. Nilotinib in patients with systemic mastocytosis: analysis of the phase 2, open-label, single-arm nilotinib registration study. J Cancer Res Clin Oncol. 2015 Nov;141(11):2047-60. doi: 10.1007/s00432-015-1988-0. Epub 2015 May 23.
Hochhaus A, le Coutre PD, Kantarjian HM, Baccarani M, Erben P, Reiter A, McCulloch T, Fan X, Novick S, Giles FJ. Effect of the tyrosine kinase inhibitor nilotinib in patients with hypereosinophilic syndrome/chronic eosinophilic leukemia: analysis of the phase 2, open-label, single-arm A2101 study. J Cancer Res Clin Oncol. 2013 Dec;139(12):1985-93. doi: 10.1007/s00432-013-1529-7. Epub 2013 Sep 22.
Stein AM, Martinelli G, Hughes TP, Müller MC, Beppu L, Gottardi E, Branford S, Soverini S, Woodman RC, Hochhaus A, Kim DW, Saglio G, Radich JP. Rapid initial decline in BCR-ABL1 is associated with superior responses to second-line nilotinib in patients with chronic-phase chronic myeloid leukemia. BMC Cancer. 2013 Apr 2;13:173. doi: 10.1186/1471-2407-13-173.
Kantarjian HM, Giles FJ, Bhalla KN, Pinilla-Ibarz J, Larson RA, Gattermann N, Ottmann OG, Hochhaus A, Radich JP, Saglio G, Hughes TP, Martinelli G, Kim DW, Shou Y, Gallagher NJ, Blakesley R, Baccarani M, Cortes J, le Coutre PD. Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results. Blood. 2011 Jan 27;117(4):1141-5. doi: 10.1182/blood-2010-03-277152. Epub 2010 Nov 22.
Kantarjian HM, Giles F, Gattermann N, Bhalla K, Alimena G, Palandri F, Ossenkoppele GJ, Nicolini FE, O'Brien SG, Litzow M, Bhatia R, Cervantes F, Haque A, Shou Y, Resta DJ, Weitzman A, Hochhaus A, le Coutre P. Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood. 2007 Nov 15;110(10):3540-6. Epub 2007 Aug 22.
Kantarjian H, Giles F, Wunderle L, Bhalla K, O'Brien S, Wassmann B, Tanaka C, Manley P, Rae P, Mietlowski W, Bochinski K, Hochhaus A, Griffin JD, Hoelzer D, Albitar M, Dugan M, Cortes J, Alland L, Ottmann OG. Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med. 2006 Jun 15;354(24):2542-51.
|Responsible Party:
|Novartis Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT00109707 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 2, 2005
|Last Updated:
|April 27, 2016
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Systemic Mastocytosis
CML in blast crisis
CML in chronic phase
CML in accelerated phase
Gleevec resistance
Gleevec intolerant
Gleevec and CML
imatinib resistance
imatinib intolerant
Hypereosinophilic Syndrome
Chronic eosinophilic syndrome
Philadelphia chromosome positive acute lymphoblastic leukemia
Ph+ ALL refractory to standard therapy
Ph+ALL relapsed
Additional relevant MeSH terms:
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Philadelphia Chromosome
Mastocytosis, Systemic
Blast Crisis
Hypereosinophilic Syndrome
Pathologic Processes
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Translocation, Genetic
Chromosome Aberrations
Neoplasms, Connective Tissue
Neoplasms, Connective and Soft Tissue
Skin Diseases
Cell Transformation, Neoplastic
Neoplastic Processes
ClinicalTrials.gov processed this record on September 21, 2017


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Come in from the Firefly DarknessAmy Feldman Bernon - Heritage Music Press
This exquisite work has a haunting yet whimsical quality as it tells its story from the viewpoint of a wanderer who has returned home to share life's experiences, only to leave again in the final, bittersweet measures. "Open up your door, my friend, and let me come in from the firefly darkness..." A beautifully poetic text, set to shimmering music, this sings so naturally that it will really let your voices soar! (The P/A CD is compatible with the SATB, three-part mixed and TBB editions; the SSA is in a different key.) �
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Replacing sub floor in Railroad Diesel Car
I volunteer at the Old Colony & Fall River Railroad Museum, Inc. We work on restoring vintage railroad equipment and by Ryobi tools are very helpful both wired and battery operated. Some of the railroad cars do not have electrical hook-ups so it is essential to have good battery operated tools. The picture is the replacement of a portion of the subfloor in a 1953 built Rail Diesel Car. It was a unique experience because the sub-floor is mounted on stainless steel channels. If I win the contest, half of the prize will be shared with the Old Colony & Fall River Railroad Museum, Inc. It will save myself and other volunteers from having to bring our on tools. Thank You.
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text:
Loads and loads of ideas are duplicated, many of which come from new members proposing the same question, some are posted even after a search.My idea is that whenever an idea is duplicated by a duplicator, they include the words that they searched the community with.
Why is this helpful?:
1) It will show others the kinds of words searched.
2) It will help the OP to learn how to search (if they are new.)
3) It will show the sort of searches for different ideas.
For the little effort it takes to implement, it will have a big impact on the ideas section, perhaps reducing the number of duplicates as members will learn to search differently.
Oh and for the record I searched: Automatic duplication, detection, duplicators include searched words. etc.
@cim thanks for clearing that up
I still dont see how it could be more effort, they will have to write the message telling everyone that its a duplicate so it'll hardly be any more work.
ryaneberry wrote:
Andy0 I also think this but how often do members not search? We all know the classic ideas that come around all the time, they obviously haven't searched for it, in an ideal world they will but you can't make them also it isn't anymore work done by the duplicator because they have to search for the idea so all the extra work is a bit more typing
I think the problem is more that someone didn't search, rather than they couldfn't think of which words to use.
For instance, how many ideas have you posted which have been marked as duplicates?
It is not faulty. I've lost count of the number of times someone said they searched and didn't find anything, yet if one does the search oneself there are tens of results, or even a hundred or more.
It isn't all that much an idea for giffgaff to consider anyway. The volunteers marking threads as duplicate ideas have their own discretion about any comment they add, and they do already sometimes say please use the search function.
ryaneberry wrote:
It's true about mentioning the search function but what use is it if you don't know what to search?
Sorry, I really don't understand the question. What do you mean, people don't know what to search for?
The search function finds words, so search for words which are relevant to the subject. You might as well say people can't think of a thread title to describe their idea. But that would be implausible, of course they can, and as a first approximation that mght also be a clue to what to search for, then if it doesn't narrow it down try again by adding a word or two
I think this thread is picking up on a really important point, but i also think (with the greatest of respect) that you're both slightly missing why duplication happens... Language is the important thing here...
I just searched for 'copied ideas' - a pretty simple way of thinking about what this thread is really all about. It's also a much simpler and more understandable phrase than 'duplicating -include searches words'. Anyway, on searching for 'copied ideas' there was no link to this thread as these words, despite being highly relevant, haven't been used (of course searching this now will link to this and so close this gap...).
But the point is, unless you correctly second guess the language of other users, new duplicates will continue to occur.
While the title of this idea might be inclusive of root words used in your own searches, it didn't include the root words of my search despite the same intention.
Simple language is obviously best, but people get very techy in these environments and your average, well-meaning GiffGaffer might not be the sharpest tool in the information technology box!
Maybe GG should call for all idea and discussion titles to be in plain English? However this may of course lead to a greater number of FALSE positives when searching as titles will be more similar...
However, I think the answer to this is in improving the clarity of original posts, rather than teaching every GG user the finer points of search optimisation (which won't help anyway if their written English and grasp of synonyms ain't great).
It's not always the 'fault' of the duplicator, the duplicator has to have a good enough grasp of the language used by other GiffGaffers in order to find their posts, andthe original poster needs to use language that subsequent users might search for...
Hope i haven't missed the point of this discussion -epic fail if I have!


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Important Bird Areas
Four Eastern Saline Wetland sites in Lancaster and Saunders counties are part of Audubon Nebraska's Important Bird Areas (IBA) program. The IBA program identifies key sites in Nebraska that are critical to the survival of birds, and promotes the conservation of these sites in order to maintain healthy bird populations. The program is part of an international program overseen by National Audubon in the United States and BirdLife International in over 150 countries around the world.
Important bird areas provide essential habitat for one or more species of birds, either during breeding season, on migration, or in winter. These areas range in size from a few acres to thousands of acres, and can be found on public, private or mixed ownership lands.
Bird Survey Data from the 4 Eastern Saline-Wetland IBA's:
- Arbor Lake and Adjacent Little Salt Creek
- Frank Shoemaker Marsh
- Jack Sinn Wildlife Management Area
- Whitehead Saline Wetlands
Data from Additional Saline-Wetland Bird Surveys:
- Upper Little Salt Creek Saline Wetlands Bird Day 5/14/2014
- Frank Shoemaker Marsh Bird Day 5/28/2008
- Frank Shoemaker Marsh Bird Count (1975-2007)
- Spanning firve saline wetland locations - Bird Record (1980-1987)


text:
Before the Internet, and Apple (AAPL) iPads and iPhones, at the start of a fresh year for the market there were pens, papers and a good old-fashioned calculator -- along with a degree of imagination from the folks on Wall Street. Naturally, all investors wanted was to arrive at a fair-value estimate for one's index of choice, or for a specific stock, by adherence to basic principles of investing, instead of positioning one's portfolio to win with the next headline.
With that in mind, I return to yesteryear with this prediction piece. I'll outline two themes I plan to use as my foundation for stock selection in 2013 -- or, at least, until that headlines force me to change.
Theme No. 1: Corporate Restructuring Actions Are Finally Rewarded in Stock Valuations
Beginning in the second quarter, because of general disappointment in the trajectory of sales and earnings in 2012, many companies announced previously unplanned restructuring actions. That resulted in charges to assets on the books, and likely a lower level of aggressiveness on shareholder-friendly initiatives (think stock-buybacks and dividend increases).
In 2013, I expect significantly restructured companies to finally enjoy margin upside on mediocre volume. These include names, such as Boeing (BA) and Caterpillar (CAT), that have cut more low-hanging fruit and developed new processes, among other things. Should the global economy dig itself out of mediocrity, possibly in the second half of next year, profit margins from restructured companies will only look that much better. Firms with profit-margin upside, in turn, will likely return cash to shareholders paying higher tax rates.
Mental note: Companies that have undergone major restructuring plans are usually the names on which the Street has become too cautious, with a beat-and-raise pattern established with respect to earnings estimates.
Theme No. 2: Seek the Needle-Moving New Product or Service
Forearm to throat, Apple shares stand to be higher on Jan. 1, 2014 than they are today, even though its product pipeline is being skewed toward evolutionary, rather than revolutionary. In turn, Apple will win from its reputation among consumers -- which should create strong global volume, plus a lower cost base.
However, I want to rock out in 2013 by seeking a company that has guided to a new product or service that could be surprisingly influential on profits, with the Street caring little in the present. One such name is Take-Two Interactive (TTWO), which trades at 5x forward earnings in front of a major launch of a new iteration of its "Grand Theft Auto" title. Additionally, I have been quite pleased by the strength of the company's catalog business. The company could also see further benefit from a smaller rival, THQI (THQ), being forced to close up shop due to financial troubles.
The Silly S&P 500 Prediction
I am personally no fan of chucking an S&P 500 target out into the universe. It's my opinion that, through rigorous research of individual stocks, one could do far better than buying an index fund and calling it a day. In this market, nimbleness is rewarded. It's silly to pay homage to a target on the S&P 500, as this would mean a failure to bob and weave throughout the year. Nevertheless, since I know you are wondering, my fair-value estimate on the S&P -- derived using modest growth and multiple assumptions -- is 1560. I estimate gains will be weighted toward the back-half of the year.


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Lyft is available at Wichita Dwight D. Eisenhower National (ICT) Airport. As long as you follow a few simple ground rules, you're in the clear for both pickups and drop-offs.
Review Airport Regulations Do's & Don'ts
Drivers on the Lyft platform are responsible for knowing and following all airport regulations. As a driver, you must follow the rules listed below in order to avoid receiving administrative citations from ICT Airport.
Waiting for requests
- Wait in the designated staging area. Only drivers within the designated staging area (Cell Phone Lot) are added to the queue.
- The queue is first in-first out. The driver who has been waiting within the staging area in driver mode the longest gets the next request. Your physical location within the staging area does not affect your spot in the queue, but if you exit the staging area or log out of driver mode, you will lose your spot.
- If the staging area is full, you must leave the airport. You may not wait for requests anywhere else on airport property or use any other parking lots while in driver mode.
- Passenger cancellations don't affect your place in line. If your passenger cancels on you, head back to the staging area. As long as you're back within 5 minutes, you'll be placed at the front of the queue.
- Driver cancellations and missed requests do affect your place in line. If you are the one to cancel a request, or if you miss a request, you're placed at the back of the queue.
- You can view your place in line in the app. Learn how to view your position in the queue here.
- Pick up passengers from the Close In Lot, in one of the Lyft spaces — look for the "Rideshare Companies" signs. Parking is free for 30 minutes.
- Do not wait or circle back at the airport if the passenger is delayed when picking up. Instead, wait in the staging area.
- Short ride bump: If you receive a request for a short ride from the airport after waiting in the queue, you may qualify for a higher queue position after you drop off your passenger. You'll receive an SMS after dropping off to let you know you have the option to return to the staging area for a preferred spot in the queue. Please note, if you give a ride before returning to the staging area, you may still qualify for a preferred spot in line.
- Drop off passengers curbside at the terminal entrance, at your passenger's carrier of choice.
- Do not wait at the airport terminal after drop-off. If you'd like to wait for requests, head to the staging area.
Lyft Emblem
Keep your Lyft emblem displayed and visible at all times while giving Lyft rides.
If you are giving a non-Lyft ride at the airport, make sure to remove your emblem before entering airport property.
If you've been approved to drive, you should receive your Lyft emblem within a couple weeks. Didn't receive one? Let us know and we'll look into it. In the mean time, you may print your own temporary emblem.
If You're Approached by an Airport Authority
Authorities at the airport may approach you and ask you for a waybill.
The waybill allows law enforcement officials to see information about your current or most recent ride.
To access your waybill, follow these steps:
- Go to your Dashboard*.
- Tap Waybill in the left side menu.
*Access your Dashboard either through the left panel menu in the Lyft app, or by going to lyft.com/drive in a web browser.
If you run into any trouble, reach out to our Support team. We're here to help 24/7.


text:
Salt Intake and Antiproteinuric Effect of Paricalcitol in Type 2 Diabetes (PROCEED)
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- How to Read a Study Record
Proteinuria is an independent risk factor for cardiovascular morbidity and mortality and for renal disease progression. More proteinuria is associated with faster progression, whereas treatments that reduce proteinuria are renoprotective in both diabetic and non diabetic chronic kidney disease. Of note, lower the residual proteinuria achieved by treatment slower is the disease progression in the long term. On the basis of the above findings, proteinuria has become a target of renoprotective therapy.
Among different antihypertensive medications, those that inhibit the Renin Angiotensin System, such as angiotensin converting enzyme (ACE)inhibitors and angiotensin receptor blockers (ARBs), are those that at comparable blood pressure control, more effectively reduce proteinuria and slow renal disease progression. Thus they have become the key component of renoprotective therapy in patients with proteinuric chronic kidney disease. Observational studies found that their effectiveness, however, is limited or even fully blunted in patients who eat large amount of salt.
Experimental evidence indicates a renoprotective role of the vitamin D system in chronic renal disease. A recent randomized, controlled trial, add-on therapy with selective Vitamin D receptor activator paricalcitol showed an additive antiproteinuric effect in subjects with type 2 diabetes and chronic kidney disease on background Renin-angiotensin-system inhibitor therapy. This effect, however, was largely restricted to subjects with daily sodium intake exceeding 12 grams and was negligible in those with lower sodium intake. Thus, treatment with paricalcitol appears to be effective in particular in those patients who do not appreciably benefit of renin angiotensin system (RAS) inhibitors therapy because of high salt intake. Thus, whether the antiproteinuric effect of paricalcitol is modified by concomitant salt intake in patients with chronic kidney disease (CKD) on background RAS inhibitors therapy, is worth investigating.
The broad aim of this study is to evaluate the interaction between paricalcitol therapy and sodium intake in type 2 diabetes patients with proteinuric kidney disease on stable background RAS inhibitor therapy.
|Type 2 Diabetes
|Drug: Paricalcitol Other: placebo
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|A Prospective, Randomized, Cross-over, Double-blind, Placebo-controlled Study to Assess the Antiproteinuric Effect of Selective Vitamin d Receptor Activation by Paricalcitol in Type 2 Diabetes Patients on Low or High Sodium Diet and Stable Ras Inhibitor Therapy
- Changes in urinary albumin excretion from baseline at 4 month. [ Time Frame: At baseline and 1,2,3 and 4 month. ]
- Ambulatory and 24-hour blood pressure profile. [ Time Frame: At 1 month. ]
- Ambulatory and 24-hour blood pressure profile. [ Time Frame: At 2 month. ]
- Ambulatory and 24-hour blood pressure profile. [ Time Frame: At 3 month. ]
- Ambulatory and 24-hour blood pressure profile. [ Time Frame: At 4 month. ]
|Study Start Date:
|September 2011
|Study Completion Date:
|July 2015
|Primary Completion Date:
|July 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: Paricalcitol
Drug: Paricalcitol
1-month Paricalcitol 2mcg/day
|Placebo Comparator: placebo
Other: placebo
1-month Placebo Treatment
|Ages Eligible for Study:
|18 Years to 80 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male and female patients;
- Age > 18 years;
- Type 2 diabetes patients on low or high sodium diet and stable RAS inhibitor therapy with the following conditions:
Urinary albumin excretion (UAE) rate >300mg/24 hours (200 mcg/min); Serum creatinine <2 mg/dL, PTH ≥ 20 mEq/L and <110 mEq/L; Calcium and phosphorus levels < 9.5 mg/dl and < 5mg/dl, respectively; Controlled BP (systolic/diastolic <140/90 mmHg) while on stable RAS inhibitor therapy;
- Written informed consent.
Exclusion Criteria:
- Previous Vitamin D or Vitamin D analogs therapy (within 3 months prior to the study entry);
- Evidence of toxicity to Vitamin D;
- History of kidney stones;
- Poorly controlled Diabetes: Hb1Ac > 12%;
- Therapy with calcitonin, bisphosphonates, cinacalcet, glucocorticoids, immunosuppressive drugs or other drug that may affect calcium or bone metabolism;
- Cancer and any severe systemic disease or clinical condition that may jeopardize data interpretation or completion of the study;
- Any clinically relevant conditions that might affect study participation and/or study results;
- Any contraindication to be exposed to Paricalcitol;
- Pregnancy or lactating;
- Women of childbearing potential without following a scientifically accepted form of contraception;
- Legal incapacity.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01393808
|ASL of Ponte San Pietro - Diabetologic Unit
|Brembate, Bergamo, Italy, 24030
|Clinical Research Center fo Rare Diseases Aldo and Cele Daccò
|Ranica, Bergamo, Italy, 24020
|Azienda Ospedaliera di Treviglio e Caravaggio - Unit of Diabetology and Metabolic Diseases
|Romano di Lombardia, BG, Italy
|Azienda Ospedaliera Bolognini - Unità di Medicina
|Seriate, BG, Italy
|Azienda Ospedaliera di Treviglio e Caravaggio - Unit of Diabetology and Metabolic Diseases
|Treviglio, BG, Italy
|Azienda Ospedaliera Ospedali Riuniti di Bergamo
|Bergamo, Italy
|Responsible Party:
|Mario Negri Institute for Pharmacological Research
|ClinicalTrials.gov Identifier:
|NCT01393808 History of Changes
|Other Study ID Numbers:
2011-001713-14 ( EudraCT Number )
|Study First Received:
|July 12, 2011
|Last Updated:
|March 2, 2017
Keywords provided by Mario Negri Institute for Pharmacological Research:
Type 2 diabetes
Sodium intake
Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
In the Wellcome medical collections, there are lots of relics relating to famous people, some of which have featured on this blog. Many of them are from the great men of medicine and science, Joseph Lister, Louis Pasteur, as well as military and naval men, Nelson, Napoleon and Wellington.
In the Wellcome Library, only one woman's name made the inscription in the Reading Room: Florence Nightingale.
Not so with the collections though. During one visit to the stores I came across a curious item: Khaki haversack, belonging to Dr. Caroline Matthews. Intrigued, I started searching through Wellcome Images.
So just who was Dr Caroline Matthews (1878-1927)?
After graduating from Edinburgh Medical College for Women in 1903, Dr Matthews spent most of her time on the continent. We are fortunate enough to have some of her medals for her services during the Messina Earthquake in Italy, 1908 and with the Italian Red Cross.
During the Balkan War of 1912-13, she was war correspondent for the Sphere, and held the rank of surgeon in the Montenegro army and was also awarded a medal for her services.
Dr Matthews wrote Experiences of a Woman Doctor in Serbia, published by Mills and Boon in 1916, in the middle of the First World War or the 'Great Upheaval' as Caroline called it.
The book recounts her journeys through Serbia with the Scottish Women's Unit, her time as a Prisoner of War and her journey back to London in 1915. Quite possibly my favourite part of the book is her account of stocking up on supplies, with her "English RAMC (Royal Army Medical Corps) 'Tabloid' case on which to rely." Tabloid was the brand name of Burroughs, Wellcome & Co. Maybe she carried her supplies in the haversack, now sitting in the Science Museum stores?
I've been trying to work out why this material is in the collection. It was acquired from a private collection, just five months after her death. I feel a part 2 to this blog coming along…..


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SANTA CRUZ -- Computers that were stolen from four office buildings might have been taken for data that could be exploited by identity thieves, police said Thursday.
Doors were pried open in all but one of the burglaries, which have happened on Soquel and Pacific avenues since Jan. 1. Police believe the burglaries are linked.
"In all of them, computer equipment and servers were taken," Santa Cruz Deputy Police Chief Steve Clark said.
Police on Thursday released surveillance images of one of the burglaries, which happened between 6:30 and 7:30 a.m. Monday at 325 Soquel Ave., an information technology services firm.
A man pried open the door and took a laptop computer and a server, police said. He wore a blue jacket, khaki pants, gloves, glasses and a dark beret.
He appeared white, about 5 feet 8 inches to 5 feet 10 inches tall, and about 160 to 170 pounds, police said.
"If you're the suspect, you might want to think about surrendering -- someone is bound to recognize you from these photos," Clark wrote in a police blog post.
An interior-door alarm tripped during the burglary and the alarm company called the building owner, police said. In part because it was an interior alarm, the owner told the alarm company not to notify police, authorities said.
Police can bill building owners for chronic false alarms. Clark urged building owners to let police respond.
Computer equipment stolen has been stolen from other buildings.
An office at 340 Soquel Ave. was burglarized late Dec. 31 or early Jan. 1. Two laptop computers and at least two keyboards were taken, police said. Investigators collected fingerprints and other evidence.
Two more burglaries were reported on Pacific Avenue since Jan. 1.
Santa Cruz police ask anyone with information to call investigations at 831-420-5820 or the anonymous tipline at 831-420-5995. You can leave a tip at www.santacruzpolice.com.
Follow Sentinel reporter Stephen Baxter on Twitter at Twitter.com/sbaxter_sc


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SANTA ANA – A convicted rapist deserves the death penalty for murdering a 22-year-old pregnant housewife during a sexual assault in Costa Mesa as part of a brutal crime spree in the summer of 1988, an Orange County prosecutor told a jury Wednesday.
Jason Michael Balcom, 43, terrorized and raped four women during a six-week period after he was released from juvenile hall in July 1988, and inflicted a life of grief and anguish on the family of Malinda Godfrey Gibbons, who was beaten, sexually assaulted, bound and stabbed to death, Deputy District Attorney Matt Murphy said.
The aggravating factors of the murder, the violent attacks on the other women and the lingering devastation to those who cared about Gibbons warrants a death sentence, Murphy told the jury in his opening statements of Balcom's second penalty-phase trial here.
But defense attorney Dolores Yost said Balcom, who was 18 when the crimes occurred, was the product of a horrible upbringing by a destructive and abusive single mother who was manipulative, self-absorbed and possibly bipolar.
Yost told the jury in her opening statement that Balcom's mother rebelled against her racist parents by consorting with black men, and that she twice became pregnant with biracial children, including Balcom. Her parents rejected her and her son, and she went on to a series of dysfunctional relationships with other men, none of whom provided an appropriate father figure for Balcom, Yost said. His mother was a "broken woman," Yost said, who years later committed suicide by lying on railroad tracks.
The deputy public defender said she will ask the jury in Judge Francisco Briseño's courtroom to recommend a life term in prison without the possibility of parole because of the mitigating factors surrounding Balcom's childhood.
Balcom, who is serving a 50-year prison sentence for a September 1988 rape in Battle Creek, Mich., was convicted last year of special-circumstances murder for killing Gibbons during a sexual assault, robbery and burglary. But that same jury deadlocked at 10-2 in favor of death during a penalty phase, setting the stage for the retrial that's now under way.
It is the first of what could be 10 death-penalty trials in Orange County in 2013.
According to police reports and news accounts, Malinda Godfrey Gibbons was 22 and pregnant in the summer of 1988 when she and her husband moved into a Costa Mesa apartment to start their new life together. She was, her brother said, "the sweetest person in the world."
But a few days later – on July 18, 1988 – Kent Gibbons returned home from work and found the semi-nude body of his wife. She had been bound and gagged with his ties, stabbed in the chest and sexually assaulted. The case was unsolved for more than 25 years.
In 2004, the Michigan state crime lab contributed to a national DNA database of convicted felons, allowing Costa Mesa police detectives to compare genetic materials recovered from Gibbons' body to past and present Michigan inmates. Jason Balcom was a match.
The penalty phase is scheduled to last about three weeks.
If Balcom receives the death penalty, he will join 59 convicted killers from Orange County on death row. There are more than 700 murderers statewide who are under a sentence of death, but there has not been an execution in the state for more than seven years.


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They chose Online@RMU
RMU's accredited online bachelor's and online master's degree programs are filled with adults just like you – adults skillfully balancing multiple personal and professional roles. Adults just like you – who want to pursue a quality higher education online at their convenience.Adults just like you, and they chose Online@RMU. Here's why...
"I chose RMU because of their willingness to work with me and the flexibility they provided to adult continuing education students like myself. The online degree programs and courses, the life credits that were given to me for experiences and an apprenticeship I completed years ago, along with their willingness to accept a lot more of my previous college credits than any other college or university that I researched, made my decision easy. The Organizational Leadership department staff is the best. They all contributed to the motivation I needed to successfully complete my degree at Robert Morris, which has already helped me to improve my future." -Jeff Malik '12, Bachelor of Science degree in Organizational Leadership and Business Management
"Pursuing an online MBA at RMU has been a positive experience. I feel good about earning my online MBA at RMU because just like the traditional MBA, the online MBA meets AACSB accreditation standards. This AACSB accreditation makes my MBA superior to others. I am excited about the variety of career options that will open up for me when I finish my online MBA. I expect to move into a position that will allow me to fully utilize the skills and the knowledge that I learned while attending RMU." -Seth Dickerson, Master of Science in Business Administration, Medical Technologist at West Penn Hospital
"The RMU online master's degree program has provided me the opportunity to continue my education with some amazing professors and students while keeping my busy professional and personal life. The online master's degree allows me to balance my life while learning dynamic information at a institution with a fine reputation." -Chaz Kellem, Master of Science in Organizational Leadership, Manager of Diversity Initiatives at Pittsburgh Pirates
"I chose RMU for my online MBA degree for two reasons - credibility and flexibility. I completed my undergraduate degree at RMU and am very familiar with the quality of their learning programs and standards, including the AACSB accreditation of both the traditional and online MBA. Also, I work full-time and have a family, so the flexibility is essential for me to be able to complete the online MBA program. While the work is challenging and time consuming, I am able to do it without sacrificing the time I spend with those that are closest to me. If I had to choose all over again, I would still do the online MBA program and it would definitely be at RMU." -Bob Kennelly, Master of Science in Business Administration, Regional Finance Manager at Black Box Corporation
"I chose to get my online master's degree from RMU not only because it is an accredited school but because it is conveniently located to my house and is military friendly. As a full time mom, the online master's degree program offers me the flexibility to choose whether I want to take classes fully online or hybrid. The staff is friendly and always willing to help." -Jodi Hample, Master of Science in Instructional Leadership, Homemaker/Mother
"I would not have considered any other school to pursue my online master's degree and I am amazed by the level of support I have received from the RMU team. People such as Deborah Hoey, Carol Kraus (Online Student Services) and Bernadette Jablonski (Financial Aid) go beyond what is expected of them in this environment." -Lisa Wood, Master of Science in Organization Leadership, Statewide Director of Procurement Technical Assistance Centers, State of Ohio


text:
This Salted Key Lime Pie ($10) is intense. The flavors come as a one-two tart and salty punch. It's only after your tastebuds recover from that initial shock of flavors do you focus on the creamy, cool pie filling. It's a supple custard just firm enough to hold its shape, all set into a graham cracker crust. The key limes (both juice and zest) are tempered with shaved, toasted coconut and a strawberry-rosé sorbet.
Make sure to also try the Blueberry-Nectarine Pie before the end of the season. It's a might fine double crust slice with equal proportions of the tiny sweet berries and nectarine wedges—the accompanying scoop of elderflower frozen yogurt is no afterthought.
The Dutch
131 Sullivan Street New York, NY 10012 (map)
About the author: Originally from Honolulu, Kathy YL Chan blogs at Kathy YL Chan, where she chronicles her eats and travel adventures between Hawai'i, New York and beyond. She firmly believes that there is always room for dessert.


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IHS: 2012 Chip Market to Decline
12/3/2012 Post a comment
EL SEGUNDO, Ca -- Amid increasingly weak economic conditions that are depressing consumer and business spending on electronics, IHS is downgrading its forecast for the global semiconductor market in 2012, with revenue now expected to decline by 2.3 percent for the year.
Worldwide chip sales are expected to decrease to $303 billion in 2012, down from $310 billion in 2011, according to preliminary results from the IHS iSuppli Competitive Landscaping Tool (CLT) and Application Market Forecast Tool (AMFT) from information and analytics provider IHS (NYSE: IHS).
The newly adjusted figure shows a steeper descent compared to the 0.1 percent retreat first projected in the previous August AMFT forecast and the 1.7 percent decline forecast in the September AMFT. Even so, the prognosis remains the same: this will mark the first annual decline for the global semiconductor industry since 2009.
Five out of the six major application markets for semiconductorsincluding the key computer segmentare expected to contract in 2012, pulling down the overall performance of the chip market, said Dale Ford, senior director, electronics and semiconductor research for IHS. An extremely weak global economy resulted in poor demand for electronics. As a result, the semiconductor industry slipped from stagnation in the first half of 2012 to a slump in the second half. Still, one of the few silver linings is that the fourth quarter is expected to bring a mild recovery in year-over-year growth, setting the stage for a market rebound in 2013.Computer crash
Among the various semiconductor application markets, the data processing, consumer electronics, industrial, wired communications and automotive segments all are expected to deteriorate in 2012, with only the hot wireless segment set to expand.
The PC-dominated data processing segmentthe largest semiconductor application marketis on track to plunge by 7.8 percent this year. Global PC shipments will shrink in 2012 for the first time in 11 years, due to a combination of economic factors and competition with new platforms, including media tablets.
On the other hand, wireless semiconductors will be the only application market to grow this year.
The surge in popularity of smartphones and media tablets is driving healthy growth in the overall wireless semiconductor market segment in 2012 with a projected 7.7 percent expansion, Ford said. However, all of the other end markets for semiconductors will see revenues fall in 2012, negating all the positive effects of the wireless segment.Quarter pounding
Both the sequential and year-over-year quarterly increases throughout 2012 have been very disappointing, with sequential second- and third-quarter growth amounting to just 2.7 percent and 3.1 percent, respectively. Only the fourth quarter of 2012 is expected to show year-over-year improvement, with a slight 1.9 percent uptick compared to the fourth quarter of 2011.
Nonetheless, this slender growth in the fourth quarter could set the stage for a return to a consistent pattern of expansion in 2013.
Lucky 2013?
Three out of the four worldwide regions are on course to suffer a retreat in semiconductor revenue this year. Europe, Middle East and Africa (EMEA) will drop by the greatest margin of all regions, with a 9.3 percent fall. Japan will contract at a 4.7 percent rate, while the Americas will decline by 4.6 percent.
Shipment of semiconductors to the Asia-Pacific region will grow barely, up just 0.3 percent.Part problems
Illustrating how widespread semiconductor weakness is this year, every chip-component segment is set to suffer a revenue decrease in 2012 with only four exceptions: CMOS image sensors, light-emitting diodes (LEDs), application-specific logic integrated circuits (ICs) and sensors.
CMOS image sensor revenues are forecast to deliver extremely strong results, with 31.8 percent annual growth. Also, LEDs will deliver double-digit revenue increases at 17.5 percent. IHS likewise estimates that application-specific logic ICs and sensors will see solid expansion of 5.6 percent and 4.1 percent, respectively.
Once again, memory markets are exerting a significant drag on the semiconductor market with a combined forecast decline of 10.7 percent. Even the typically hot NAND flash memory market will witness a revenue decline in 2012.
Discrete component revenues will fare equally as bad as memory, with revenue falling by 10.6 percent. Digital signal processors (DSPs) are expected to suffer the most dramatic reduction, as revenue in this category plunges 30.9 percent. This is driven primarily by the withdrawal of Texas Instruments Inc. from the wireless baseband market.IHS iSuppli
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he Menzingers have been busy winning Europe over with their inimitable songcraft these past few days. However, the band were unfortunately robbed of thousands of dollars worth of belongings in Manchester last night. They reported on Twitter – "Well we were robbed in Manchester. Everything's gone besides our gear. Over $10,000 gone. Any help would be greatly appreciated."
There are a couple of ways you can help –
- Buy merch - link
- Banquet Records in Kingston, who are putting on the band's show at the Fighting Cocks on Saturday, have been doubling up donations of £5 at their webstore and are still taking further donations at this link - link.
The band play a few remaining dates on these shores so make sure you catch them while you can –
May 03 – ANTIfest 2012 – The Forum, Hatfield (UK) w/ Anti-Flag & The Bouncing Souls
May 04 – Joiners - Southhampton (UK)* supporting Bouncing Souls
May 05 – Fighting Cocks – Kingston (UK) headline
May 06 – Musikbunker - Aachen (DE) * supporting Bouncing Souls
May 08 – Underground – Cologne (DE) * supporting Bouncing Souls
May 09 – Batschkapp - Frankfurt (DE)* supporting Bouncing Souls
May 10 – ISC - Bern (CH) * supporting Bouncing Souls
May 12 – Rockhouse - Salzburg (AT) * supporting Bouncing Souls
May 13 - Lucaema Music Bar - Prague (CZ) * supporting Bouncing Souls


text:
They have the personal relationship with Christ that animates their work. And above all this, they have apostolic zeal a desire to share Christ with others.
I wake to the crowing of a distant rooster. Surprisingly,
I am well rested and comfortable. We have slept on
concrete floors now for five nights. The dust from the
concrete fills my nose and throat and gives me a
headache. Were high in the Sierra Madre Mountains of Mexico,
somewhere between Vera Cruz and Puebla, near a town called
Zacapoaxtla, working with hundreds of young missionaries from several countries.
Its 5:30 and I have time to say my rosary
before Fr. Juan Guerra LC of Everest Academy starts to
stir. As we get up, I check my boots for
unwanted spiders or scorpions. I havent seen any scorpions yet,
but Im not inclined to take chances. Father and I
walk down the lane to the restroom. Its a shack
patched onto the back of a house that looks more
like a sheep stable than a home. The water is
gravity fed and the ancient man who lives there breaks
up twigs to stoke the fire that heats the water
for our showers. I wait outside while Father goes first.
I can see clouds below us as I gaze down
the mountain slopes. Ive never looked down on clouds before,
except from an airplane. I grasp a nearby tree.Before long
we are on the road to visit a group of
ten missionaries at a town thirty minutes to the north.
We have breakfast here, and Father gives spiritual direction to
a couple of the missionaries from Michigan, and then strategizes
with the group leader. They schedule masses, Stations of the
Cross, confessions, and catechism classes. Fr. Juan has arranged to
take more than twenty young men from the Great Lakes
region to the annual Mega-mission run by the Legionaries of
Christ. Here we work with people of profound poverty and
infectious joy. Most are Spanish-speaking indigenous Mexicans. In one town
over the mountains to the north of us, where there
has been less Spanish influence and intermarrying, most of the
Indians speak only Nahuatl, a language common to the region.
The missionaries in this town have been here before
seven years ago. They have devised a one-page, three-language dictionary
consisting of key evangelizing and practical terms in Nahuatl, Spanish,
and English. They can see the effects of the Protestant
groups that have been very active in the region. Several
of the missionaries in our group are graduates of Everest
Academy in Clarkston, MI. These young men, aged 15 to
about 22, have given up ten days of their Easter
break, are enduring challenging physical and cultural difficulties, and have
paid several hundred dollars each to work as missionaries in
Mexico. We are scattered in villages as far as six
hours away from one another, grouped with Mexican missionaries to
facilitate communication with the townsfolk.During the course of this day
we will visit five more groups like these. Father will
hear confessions for hours on end, have a quick drink
and bite to eat, then move on to the next
town. Im his driver, but only when he gets too
tired and has to rely on me. As a Canadian,
I am a fast driver, but Im no match for
a Mexican too passive by half.We come to a
town where there are no missionaries, but the people have
faith; they are building a new church. Father teaches me
to say El padre ya llego. Va a confessar. Its
something about the priest being here and youd better get
yourself to confession. I have to write it down because
I cant remember it. Its an effort for Father to
be patient with me. He points out that I am
of limited use without fluency in Spanish. Im already well
aware of it. He tells me to go around
the village, knock on doors, and send as many people
to confession as I can. The first place I come
to has walls of corn stalks lashed together and a
roof of corrugated tin and sections of plastic tarp. I
walk all around it but I cant find a door
to knock on. I look around for a house with
a door. Later I come back to this one, when
I have more experience.The women of the town are happy
to see me and do more than their part to
facilitate communication. The men mostly laugh. It might be the
crisp new red bandana they have given me to wear
as a sort of missionary uniform. I am keenly aware
that I have not seen a single Mexican wearing a
bandana since I came to this country five days ago.
If Mexicans themselves dont wear bandanas, then I have a
lot of re-thinking to do. I take the bandana off
and try to wrinkle it up some to give it
a more weathered look. I use it to wipe the
sweat off my neck and forehead. Now it looks like
a wrinkled, wet, new bandana. The men still laugh, but
I decide that I can accept the laughter just
dont put me in a big black cauldron of hot
water and start dicing in carrots and onions. This is
where Ill draw the line.In the end, Father hears confessions
for about an hour and a half, and I recognize
some of the people as those whom I met at
their homes. Some of the men who laughed ended up
at confession after all, smiling, pleasant. I feel like
Ive helped.A woman from this town comes with us in
the car when we leave. She wants Father to see
her mother-in-law who has been confined to her house for
a long time. We go as far as the car
can go on the rocky trail, then get out and
walk the remaining two hundred yards to the shack. Its
very primitive: dirt floor, cornstalk walls patched together with bits
of cardboard, rocks and logs on top of the roof
holding the corrugated tin in place. I stand outside with
the husband, wife, and their son while Father hears the
mothers confession. The boy plays with a discarded syringe as
an American boy would play with a squirt gun. He
squirts his dad on the backside as he bends down
to pull a weed, and his mom takes the syringe
away from him. The old woman is finished with her
confession and Father calls me in to hold his kit
of holy oil while he administers the sacrament of the
sick. We carry the Blessed Sacrament with us, so he
is also able to give her communion. Because of her
illness, this may be the first time in several years
that she has received communion. She is shaking and obviously
in poor health. It is likely that this is the
last time this woman will see a priest. You can
see in her eyes how much this visit has meant
to her.I am overwhelmed at the difference between myself as
a sincere layman and this missionary priest. What he can
give to this woman by virtue of his priesthood is
a world apart form what I could ever do for
her. His priestly ministry, exercised in the stark simplicity of
this peasant home, with nothing to distract or enhance, dissolves
in my mind all concerns of scandals and news reports
back home. Here I know for sure the nature of
priesthood. Here I see with my own eyes how only
a man who gives himself fully to God alone could
exercise this wonderful vocation to its full potential. Here I
see most poignantly that Christ gives us himself in the
sacraments of the Church. What Father Juan brings to these
people is nothing less than Christ himself and they
know it with all their hearts.Father and I talk about
these things as he drives to the next town. He
confides that he loves these moments. It clearly invigorates him
and drives him forward. The car moves faster as he
talks about it. Its Holy Thursday, and he is eager
to get to the town of San Francisco where he
will celebrate the Mass of the Last Supper. The missionaries,
including three from Michigan, have the townsfolk gathered in the
church waiting for us. Father celebrates mass after hearing a
couple of hours of confessions. All goes off without a
hitch. I am impressed by the formation of the young
men. They have all the elements of the integral formation
that we espouse at Everest. They are intellectually prepared to
teach the catechism, and they can communicate with the local
people with varying competence. They have learned to be organized
and work as part of a team, to apply themselves
to the task at hand despite their working conditions. They
have the personal relationship with Christ that animates their work.
And above all this, they have apostolic zeal a
desire to share Christ with others.And so on this Holy
Thursday night, the night that Christ instituted the priesthood, with
stops in other towns and more groups of missionaries and
more confessions and another mass, we work our way from
group to group. We stop just after 11 p.m. at
a villa that has been donated to our group for
the week. There are about twenty missionaries staying here. Father
and I are both exhausted. He speaks to the leader
of this group. In a few minutes hes back in
the car and we head back to the same place
where we woke up this morning. We get there close
to midnight, and Father chats with the missionaries, encouraging them,
as I unload the car and get our sleeping bags
rolled out on the concrete. Ill sleep well again tonight.By
Paul Flynn


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REVIEW SNAPSHOT®by PowerReviews
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Reviewed by 11 customers
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Best Uses
My Sprinter Van does not have a front seat console. this is great because I can slide it between the seats while driving, and keep my coffee or drinks held securely in the 2 front drink holders. Cold replacement drinks are at my fingertips. It easily slides out of the way to provide easy access to the cargo area in the van. sprinter vans are notorious for providing very poor, useless drink holders for the 2 front seat passengers. This cooler provides the basic storage for cables, chargers, phones etc that are needed to travel today. It allows you to carry these items from 1 car to another and keep them organized.
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needs to open to the right when used as a consol
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Good size, holds cold well, but no real good place for ice pack. The mesh under the top needs to be bigger for an ice pack. Making it with a 12v. Cooling system would be awesome. overall it is a good product.
Best Uses
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I use this as a tool bag, keep in place, and I can carry to the jobsite. I didn't care for the drink holders, so I removed them. So far the bag has held up with the tools inside, it's another use for the bag besides lunches.
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text: Girls' rash guard in "surf" and "swim" Item F9190 Color: NEON ROSE Size: All sizes are US sizes. 2 3 4-5 6-7 10 12 Size Charts Quantity: 1 2 3 4 5 6 7 8 9 Prices do not include taxes. Add to Bag Wishlist Add to Bag Add To Wishlist share: size & fit Product Details Winter break, here they come... Our supercute rash guards—like this "surf" and "swim" version—have a comfy fit and smart UPF 50 sun protection (think of it as SPF for clothes). Bonus: They're recommended by the Skin Cancer Foundation as an effective UV protectant—but we still suggest wearing them with sunblock for ultimate coverage. Nylon/elastane. This style features UPF 50 sun protection (think of it as sunscreen for your clothes). Machine wash. Import. Online only. Item F9190.


text:
Johnny DeVivo took the biggest job of his life — executive chef at Carmel's iconic restaurant Casanova — the week of the 2012 Pebble Beach Concours d'Elegance, the nation's premier classic car show.
Lucky for him, he was getting behind the wheel of a precise, well-engineered machine, not a used rattletrap.
"I was a little nervous because it's car week and Casanova is this big monster," said de Vivo, who left his job as sous chef at TusCA in Monterey to lead Casanova as well as sister restaurant La Bicyclette. "There are so many moving parts, yet it runs smooth. Now it's just been adding my own twists and taking it in a fantastic direction."
DeVivo (who's Italian name translates to "of life") scored the gig by wowing the Georis brothers (Walter and Gaston) during his tasting menu tryout. He had in mind what he wanted to cook, but once he walked into Casanova's walk-in cooler, he changed course quickly
"It blew my mind, they bring in the best product and the resources at my fingertips are incredible," he said.
He knew the Georis family loved the classic flavors of France and Italy, and wanted to keep the flavors simple and clean, taking additional inspiration from California. He grabbed fresh morels and chanterelles, artichokes, a beautiful branzino, a lamb shank, and just went into a happy zone.
DeVivo, who owned the restaurant Scaldoni for 15 years in southern Utah and was the personal chef for NBA legend Julius "Dr. J." Erving, loves the creative freedom he's afforded at Casanova. For example, he's excited about a duck trio he's just put on the menu (cured, smoked duck breast, duck prosciutto and a cured duck egg yolk).
During the AT&T week, Casanova led the way in celebrity appearances (NFL quarterbacks Tony Romo and Aaron Rodgers and actor Andy Garcia, to name a few), and DeVivo's staff didn't disappoint.
"We killed it," he said. "When I first got here it was like 'if it's not broke, don't fix it.' It was a phenomenal restaurant. But slowly we've been taking a step back and focusing on the details, the presentation, the flavors. I'm very hands-on. I'd rather have a knife in my hand than a computer mouse. There's a lot to live up to here."
The chef opening at Casanova came about when John Cox left to lead the epic kitchen at Sierra Mar at Post Ranch Inn in Big Sur (read what Chef Cox is up to below). And now word is La Bicyclette sous chef Christophe Bony will be the head honcho at the recently purchased and soon-to-be-transformed Rocky Point south of Carmel.
What it all boils down to is immense success for the Georis brothers. Add Georis Winery, Corkscrew Café in Carmel Valley, and a legacy of art (Walter is an accomplished painter) and music (the brothers founded the surf rock group The Sandals and wrote the music for the iconic surf flick "The Endless Summer") and you get the picture.
Cox evolves Sierra Mar
Casanova's loss of wildly creative chef John Cox became Sierra Mar's gain, and Cox has wasted little time in putting his fingerprints on the dining room perched high above the Pacific in Big Sur.
Cox has taken "locavorism" to a new level, using indigenous ingredients and wowing palates in the process. Cox uses kelp leaves to make salads, to smoke abalone or to cure fish. He serves what he calls "indigenous caviar," the eggs of herring laid on blades of kelp (a huge delicacy in Japan), wild strawberries that grow in the redwoods, semi-wild boar (a Carmel Valley purveyor cross-breeds the native boar with a Berkshire pig) and smoked hay (the natural alfalfa growing in Big Sur adds a nice smoky element to meats).
All this chef brain power has led to a Citrus, Chocolate & Spice dinner on Thursday, a series of unconventional meals from guest chefs.
Thursday's dinner will feature guest pastry chef Michael Laiskonis, creative director of New York City's Institute of Culinary Education and former executive pastry chef at renowned Le Bernardin, along with Sierra Mar's pastry chef Yulanda Santos.
The dinner will offer eight courses, with optional wine pairings from Sierra Mar's wine cellar (which last year regained its coveted Grand Award designation from Wine Spectator, and is a semifinalist for Best Wine Program as part of the 2013 James Beard Awards). The event begins at 5p.m. with passed canapés and Champagne, followed by the dinner at 6p.m. The most interesting item on the menu? Chocolate consommé with mole spices, braised oxtail, mandarinquats (a cross between a mandarin and a kumquat) and black garlic. Cost is $140 per person and the optional wine pairing is $75, plus tax and gratuity). Reserve at 667-2200.
The following day chef Laiskonis will host a cooking demonstration and class at 1p.m. in the green cooking classroom at MEarth (Carmel Middle School). Tickets: www.brownpapertickets.com/event/319700
Dream team of chefs
Five of America's most talented and promising chefs will visit Aubergine in Carmel on March 9 for an unprecedented dinner showcasing our coastal diversity. Aurbergine Executive Chef Justin Cogley will host Scott Anderson (chef-owner of Elements in Princeton, N.J.), George Mendez (chef-owner of Aldea in New York), Matthias Merges (chef-owner of Yusho in Chicago), John Shields (formerly chef of Town House in Chilhowie, Va.) and James Syhabout (chef-owner of Commis in Oakland).
This dream team will collaborate on a 12-course tasting menu called Rediscovering Coastal Cuisine, to be held at the newly renovated Aubergine inside L'Auberge Carmel. Cost is $250, along with a $110 wine pairing option.
Rio Grill's Flavor Education Series continues from noon-2p.m. on Saturday, March 23, as executive chef Cy Yontz teams up with local fishmonger Robbie Torrise. Enjoy a three-course meal, cocktail pairings and a talk by Torrise, owner of Robbie's Ocean Fresh Seafood. Cost is $65. Call 625-5436 ... Lopez Restaurante y Cantina in Monterey has renovated its bar area, complete with a new tequila-centric drink menu. Look for custom tile work, new sinks and new shelves to hold the beloved agave juice. Should be completely finished by the restaurant's next tequila tasting on March 4 ... Crews are gutting Habanero's in Old Monterey, which begs the question: Who is next to take over this ill-fated location? Stay tuned ... Nice to see winemaker/foodie Steve Pessagno reviving Restaurant 1645 concept at his winery on River Road (1645 to be exact). He's calling it a Guest Chef Series and dinners will be quarterly. I'm told the January dinner with chef Mo Tabib of The Fish Hopper went swimmingly. Look for another guest chef on April 5. More later.
Reach Mike Hale at email@example.com and hear his weekly restaurant radio show each Wednesday at noon on KRML 102.1 FM.


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A Murray man will spend the rest of his life in prison for fatally shooting two men following an argument over directions, the Utah Board of Pardons and Parole has decided.
Christian C. Sweeten, 31, pleaded guilty to the aggravated murders of Michael T. Ehlert and Anthony M. Gaines in August 2011.
Sweeten shot the two men in September 2008 after he asked them for directions and ended up back where he started, near 500 North and 1000 West in Salt Lake City. Sweeten, who turned himself into police hours later, initially claimed he was acting in self-defense when he shot each man in the back.


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Priming the Pump: New Money Means Big Business
By Doug McInnis
American business runs on money. Without it, the best inventions will never become tomorrow's promising startups, and even mature businesses will wither and die. But the sources of business financing are rapidly changing. Hundreds of billions of dollars from private equity financing have poured into the business world, bringing about a fundamental restructuring of the American economy in ways that should help U.S. businesses profit in the blistering competition of the global economy.
"Private equity investment is huge," says Dan O'Connell, a 1968 graduate of the University of Illinois and director of the Golder Center for Private Equity and Entrepreneurial Finance at the College of Business. "It's everything from investors who finance the guys working in their garage on what may become the next Apple Computer to the group of investors involved in international transactions. And it's everything in between."
You only have to look down the road from the College of Business to see how the concept of private equity funding is being put to work to reshape the economy. The University's Research Park on the south edge of campus is home to 50 companies that employ nearly 1,000 people. Many of these companies are startups working to commercialize technologies that originated in labs at the University of Illinois, which has gained a reputation as one of the nation's top ten invention factories. The money for many of these startups comes from Illinois Ventures, a private equity firm with offices in Chicago and Champaign. The firm draws its capital from the University, the state of Illinois, and from private and institutional investors. By helping to jump-start the tech companies of the future, Illinois Ventures is helping to grow new companies that will replace old-economy jobs that are being lost.
"We're active in life sciences, information technology, and the physical sciences," says John Banta, a 1983 graduate in finance and the CEO and managing director of Illinois Ventures. "But we're particularly interested in areas where those domains converge. That's where interesting problems tend to get solved, because people who don't normally work together do work together. And that's where the real innovation takes place in areas like energy, advanced materials, new media, and specialized software."
Moreover, the fund takes an activist role in funding innovation. "Traditionally, universities have relied on an approach where ideas were thrown out into the marketplace and then they would see which ones stuck," explains Banta. "We look for problems that need a solution, and then we go to universities and federal laboratories and see if they have technologies that might solve them."
According to Murillo Campello, an associate professor of finance, the United States is about the only country where you could have this kind of emergence of the private equity market. "In America, complete strangers are willing to look at someone else's idea," he says. "They can come in with plenty of money and make the thing a reality."
Campello, whose teaching focuses on international corporate finance, explains: "Other countries do use private equity, but not to the extent found here. That gives the United States an edge."
Something Old, Something New
New firms looking for startup capital aren't the only beneficiaries of private equity funding. Old-line firms are also being reshaped through leveraged buyouts (LBOs), which are often partially financed by a pool of private equity capital.
Giant LBO specialists, such as Kohlberg Kravis Roberts & Co. or the Carlyle Group, for example, may swallow a company in its entirety, or they may buy a division or subsidiary of a large company looking to shed a unit that no longer fits its corporate goals. After the buyout takes place, private equity may take an active role in trimming fat or selling off units that don't fit.
"Private equity makes U.S. firms more efficient and that helps them compete in the global economy," says Michael Weisbach, who holds the Golder chair in corporate finance at the University and serves as academic director of the College's Golder Center for the Study of Private Equity and Entrepreneurial Finance.
Because the investment is privately done, private equity investments aren't subject to the same pressures for quarterly profit growth as investments made by public firms. This is an advantage because it allows firms financed by private equity to seek substantial long-term growth rather than simply trying to better the previous quarter's results. This strategy allows fragile startups to develop their products and find a place in the marketplace without pressure from bankers or investors for quick results. It is an ideal arrangement to nurture the new economy.
Risky Business
In many ways, private equity is the polar opposite from most bank lenders. "A bank loan officer is not trained to know much about the fundamentals of the businesses they finance," says Campello. "They think in terms of red light, green light. Banks look at accounting ratios (an indicator of a company's financial health). They think in quarterly terms, never more than a year. Private equity investors think in terms of three years to five years and beyond depending on the type of investment. With private equity, you're more involved with the idea behind a venture, rather than accounting ratios."
But there is a price. Private equity firms often insist on a hefty ownership stake in the firms they finance.
For private investors, the rewards are potentially huge. So too are the risks. "When you invest in a startup, the investment may go nowhere," says Weisbach. "You're betting on a home run. You're looking for the next Google."
With that in mind, it's not surprising that the major players in private equity deals include wealthy individuals and institutional investors such as pension funds. Typically, though, these investors only put a portion of their portfolios into private equity. The balance tends to be in safer investments.
Tending to the Herd
Private equity is not without controversy because reshaping old-line companies often means fewer jobs, at least in the short term.
"The hardest thing a private equity investor has to do is shrink a company," says the Golder Center's O'Connell. "Really good private equity investors realize they are dealing with human beings. They do not casually shrink a company because they understand the impact. The good investors say, 'We can either have a lingering death for all 1,000 of a company's employees, or we can let 200 or 400 of them go so that the other 600 can survive and prosper."
So as the years have passed, private equity has given life to countless new companies and reshaped many others. O'Connell likens private equity to tending a herd of cattle over the long term. "There are two things you have to do to keep the herd healthy. The first thing you need is new calves. The venture capitalists provide the cash for that. The other thing that's needed is to tend to the existing herd. The buyout guys do that by finding ways to make old businesses more efficient."


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Cut-A-Thon And Bake Sale for the Scheff Family
Additional Information
3-5pm at Accents 3101 Hair Salon by Fuddruckers. Jeren Scheff, the one-year-old boy of Justin and Jen Scheff, was diagnosed at birth with a rare genetic disorder that makes it hard for him to breathe. He will be undergoing his 7th surgery. The Cut-A-Thon and bake sale will help with expenses. Haircuts are $10. Donations can also be made at Security State Bank in Montrose. ( Call for an appointment605-339-3575 firstname.lastname@example.com


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Rockstar RS3 Split Spoke Inserts 827SS290N-RD
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Easily install your rim accents from the comfort of your own home. Got questions? Give us a call at 877-216-5446.


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About CUNA Courses
May. 29, 2013
"People helping people" is the philosophy of the credit union movement. These interactive courses will help you gain an understanding of the basic tools necessary for providing exceptional service to your members. This course includes information on membership applications, savings and share draft accounts, loans, credit cards, ATMs, and other member offerings. Additionally, learn how you can improve member service and stay connected with your members via new technologies.
This is a CUNA CU Advance course through CUNA Professional Development Online (CPD Online) and contains individual courses for $35 each.
Course participants will have an option of taking a pre-assessment to determine which courses are needed for his or her skill level. A comprehensive exam for all 6 courses can be purchased for $24.50 through CUNA Professional Development Online (CPD Online).
Estimated length of course: Each individual course is 20-30 minutes.
$35.00CUNA member price
A comprehensive exam for all 6 courses can be purchased for $24.50 through CUNA Professional Development Online (CPD Online).
Member Accounts:
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Also available in print.
See a full CUNA course listing.
Recognition opportunities are offered at various training milestones with CUNA designations and certificates.
Select courses are recommended for college credit for students who pass proctored, college-level exams and carry college credit recommendations.
CUNA courses are a simple, affordable way to provide current, real-world training to your credit union. Courses are available in print and/or online through CUNA Professional Development Online (CPD Online). With hundreds of courses to choose from, you're sure to find learning materials to fit your credit union's needs. See a full course list.
CUNA is committed to providing a quality learning experience. If for some reason you are not fully satisfied, contact us and we'll provide you a full tuition refund or credit.
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Cccccc - Cake Central's Cupcakes Cartoon Cake
The cake is inspired by beautiful illustrations of Jessie Oleson. My daughter loved them so much that I had no choice but to make this cake. The first to be eaten was CCoggie (Cuppie Doggie), there are also Cuppie Boss, Cuppie Fairy, Player, Fitness Fanatic, Photographer, Pets and Sweets Lover, Decorator, Baseball Player and Awesome Cuppie Boss Worshhipper. The cake is vanilla, chocolate and strawberry cake, filling vanilla and cocconut IMBC, covered in fondant. Decorations fondant, gumpaste, marzipan, marshmallows and liquorice. Everything is edible (except wires and Rainbow Dust). TFL


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Know Hepatitis B: Testing for Asian Americans
Know Hepatitis B is the first multi-lingual campaign from US Department of Health and Human Services (HHS) encouraging Asian Americans and Pacific Islanders (AAPIs) to get tested for Hepatitis B. AAPIs are disproportionately affected by Hepatitis B, and the campaign uses a variety of multi-media channels in English, Chinese, Korean, and Vietnamese to reach individuals in their native language. Know Hepatitis B was developed in partnership with Hep B United and leverages the community partners as part of a grassroots approach to promoting testing for Hepatitis B on a local level. This campaign was launched with support from the HHS Office of Minority Health, and the White House Initiative on Asian Americans and Pacific Islanders.
What should Asian Americans and Pacific Islanders know about Hepatitis B?
1 in 12 Asians Americans and Pacific Islanders has Hepatitis B
Hepatitis B is common in many parts of the world, with an estimated 350 million people living with the disease worldwide. In the United States, an estimated 1.2 million Americans are infected. However, Hepatitis B disproportionately affects Asian Americans and Pacific Islanders because it is especially common in many Asian and Pacific Island countries. While AAPIs make up less than 5% of the total U.S. population, they account for more than 50% of Americans living with chronic Hepatitis B.
Hepatitis B can cause liver cancer
If left untreated, up to 25 percent of people with Hepatitis B develop serious liver problems such as cirrhosis and even liver cancer. In the US, chronic Hepatitis B infection results in thousands of deaths per year. Liver cancer caused by Hepatitis B is a leading cause of cancer deaths among Asian Americans.
2 in 3 Asian Americans with Hepatitis B don't know they are infected
People can live with Hepatitis B without having any symptoms or feeling sick. As many as 2 in 3 AAPIs living with the virus do not know they are infected. Often, people do not know they have Hepatitis B until they have been tested.
Hepatitis B can be prevented
A safe and effective vaccine is available, which prevents people from getting Hepatitis B. The vaccine is recommended for everyone at birth because Hepatitis B can be passed from an infected mother to her baby at birth, or from a family member to young children. Many people with chronic Hepatitis B got infected as infants or young children before the Hepatitis B vaccine was widely available.
Who should get tested for Hepatitis B?
- Anyone born in Asia or the Pacific Islands (except New Zealand and Australia)
- Anyone born in the United States, who was not vaccinated at birth, and has at least one parent born in East or Southeast Asia (except Japan) or the Pacific Islands (except New Zealand and Australia)
Why is testing for Hepatitis B important?
Hepatitis B testing identifies people living with chronic Hepatitis B so they can get medical care, which can help prevent serious liver damage. Testing also helps find other people who may not have Hepatitis B, but are at risk for getting infected. This can include people living with someone with Hepatitis B. These people can get the vaccine to prevent getting Hepatitis B.
How to stay connected with Know Hepatitis B
- Visit the Know Hepatitis B campaign materials page for access to posters, fact sheets, buttons, badges, radio and TV PSAs, and other resources to encourage testing for Hepatitis B.
- Sign up for email updates from DC's Division of Viral Hepatitis. These emails include a wide range of viral hepatitis related content, and will also include updates on the Know Hepatitis B campaign.
- Follow @cdchep on Twitter to get updates on the Know Hepatitis B campaign and join the conversation about hepatitis.
- Join our partners for a Twitter Chat on October 15 at 2 PM EST by using #KnowHepB. The chat will discuss the how community members, including Hep B United, are using the Know Hepatitis B campaign and raising awareness to get Asian Americans and Pacific Islanders tested for Hepatitis B. For updates on the Twitter Chat, visit our Stay Connected page.
More Information
- Page last reviewed: September 30, 2013
- Page last updated: September 30, 2013
- Content source:
- National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
- Page maintained by: Office of the Associate Director for Communication, Digital Media Branch, Division of Public Affairs


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In early October Vanguard announced that, instead of using MSCI indices for its six international-equity ETFs, it would base those funds on FTSE indices – and Vanguard Emerging Market ETF (VWO) is one high-profile ETF that will affected by the change. It means the ETF will no longer include South Korea, as FTSE does not categorize the nation as an emerging market.
As you can well imagine, the change in Vanguard's portfolio won't (and can't) be instantaneous. Gus Sauter, Vanguard's chief investment officer, said in early October that the South Korean holdings will be sold off over a 25-week period.
Plenty of ink has been devoted to comparisons between VWO and the iShares MSCI Emerging Markets Index (EEM) -- which, of course, will continue holding South Korean names. EEM's the top holding is Samsung's Korea-traded stock.
While those are behemoths within the emerging-market ETF universe, small-cap emerging-market funds offer exposure to growth upstarts. Along with that growth potential, however, investors take on added volatility risk.
An emerging-market ETF that often sneaks under the radar is the WisdomTree Emerging Market Small Cap Dividend Fund (DGS). This is a holding at my firm, Portfolio Asset Management.
The ETF is pegged to its eponymous index. The top five countries, in terms of holdings, are Taiwan, South Korea, Thailand, Malaysia and Brazil. This fund has advanced 10.18% year to date, a fractionally better performance than that of the Russell 2000 ETF (IWM), and it sports a dividend yield of 3.2%.
An even greater yield, 5.3%, comes from the SPDR S&P Emerging Markets Small Cap Fund (EWX), which corresponds to the S&P Emerging Market Under USD2 Billion Index. Many investors focus on the more prominent large-cap SPDRs, but this fund may be worth a look.
EWX struggled in the second half of 2011, finishing with a yearly loss of nearly 34%. But, so far in 2012, it has climbed 15.13%. Shares closed Friday at $43.44, 1.2% below its 10-week line.
Top country weightings are Taiwan, China, South Africa, India and Brazil. Its expense ratio is 0.65%, just fractionally higher than the DGS' ratio of 0.64%.
There is a bit of tracking error, in terms of sector-allocation drift, between the ETF and its underlying index. The fund's top three sectors are financials, industrials and consumer discretionary. The No. 2 and No. 3 positions are reversed within the index.
While the IWM is the U.S. small-cap bellwether ETF, its sister fund, the iShares MSCI Emerging Markets Small Cap Index Fund (EEMS), is not so well-regarded. It hasn't attracted much in the way of investment, with assets under management of only around $9 million -- and it's a new fund, having launched in August of last year. It tracks the MSCI Emerging Markets Small Cap Index.
Year to date, it has gained 8.25%, lagging some of its emerging-market small-cap counterparts. The top five country allocations are Taiwan, South Korea, China, South Africa and India, and the fund sports a dividend yield of 2.6% -- lower than those of some of its peers.
EEMS closed Friday at the low end of its trading range, below both its 10-week and 40-week averages. That does not bode well for a buy in the near future.


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Hi! My name is Rachael and this is my first post on this forum...
Im relatively new to disc golf (2 months in) and i have many kinks to work out. However, my most consistent issue is that my putts, when being thrown from 15+ feet out, always land to the right of the basket. I have tried aiming more to the left instead of dead center only to be filled with frustration when the disc plops happily on the baskets right.
I have a hard time drilling a lot of power into my putts and have theorized that that may be the culprit to my dillema.
Any input will be much appreciated!


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A FATHER fears his nine-year-old son will 'fester away' if he is forced to attend a special school.
Jack Entwistle, who has autism, is at the centre of a row between his parents and Lancashire County Council after he was told he could not attend his mainstream Burnley primary school.
Now Burnley MP Gordon Birtwistle is set to call for a debate in Parliament about the teaching of autistic children in Lancashire after being approached by Jack's parents and the families of two other local youngsters.
Jack's dad, Alan Entwistle, of Marsden Road, claimed St James Lanehead CE Primary had broken the 1995 Disability Discrimination Act in saying that it 'could not cope' with Jack after he was diagnosed with autism in October 2012.
Mr Entwistle and his wife, Karen, have appealed the outcome of a special educational needs and disability tribunal, in which a judge backed the county council's decision to send Jack to Pendle View Primary School, a special school in Colne.
They claim Jack, who is also visually impaired, was asked to leave the school with no notice on May 13.
He said: "There was no warning, no paperwork, nothing. He's come on leaps and bounds at St James's. He's had a teaching assistant for the last seven months and in that period he's gone through the roof.
"The problem is that LCC and the tribunal judges are not qualified to make judgements regarding placements for autistic children.
"The gist of the tribunal was that autism was not Jack's primary disability. We have a letter from Great Ormond Street Hospital saying that it is. How can they over-rule that?
"They're just throwing them on the scrapheap and into a special needs school to fester away."
Sally Riley, Lancashire County Council's head of inclusion and disability support services, said: "It would be inappropriate for us to comment on any individual case.
"When the parents of a child with a statement of special educational needs express a preference for a certain school, such as an independent special school, it is the county council's duty to consider the placement very carefully.
"Sometimes we can find ourselves at odds with the parents' preference and when this happens, a parent can take the case to the special educational needs and disability tribunal.
"Once such a case has been heard, the decision is taken out of the county council's hands. The judge's ruling is final.
"We have to abide by their directions, ensuring we take the actions they instruct us to take, within the timescales they set out."
But Mr Entwistle denied it had been his choice to remove Jack from St James's.
He said: "His mainstream school told us in October 2012 they could no longer cope with Jack.
"When we asked the county council for advice, they sent us a list of schools to look at. One was White Ash School in Oswaldtwistle and the other was Oliver House School in Chorley.
"We had interviews with both head teachers but only the Chorley one had space. LCC then used taxpayers' money to fight to stop us from sending him to the one in Chorley, which we chose, and force him into Pendle View.
"We're not troublemakers but we're not prepared to send Jack to a special school where we think he will regress. It's not the right environment for him."
Mr Birtwistle will raise the matter with the House of Commons' Backbench Business Committee next Tuesday to call for 'greater provision' for youngsters with autism.
He said: "Some of these families have been led up the garden path by the education authority and we need to look at how we can help them."


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Twins awarded No. 4 Draft pick in 2015 Round B
MINNEAPOLIS -- The Twins received an extra pick in next year's First-Year Player Draft as a result of the third annual Competitive Balance Lottery, Major League Baseball announced Wednesday.
The Twins were awarded the fourth selection in Round B, which comes after the second round of next year's Draft. It's the first time Minnesota has been awarded a pick in the Competitive Balance Lottery.
The lottery gives teams with the lowest revenues and in the smallest markets the chance to obtain additional picks in the Draft. The 10 teams with the lowest revenues and the 10 clubs in the smallest markets were entered into a lottery for the six selections immediately following the first round of the Draft.
The teams that did not receive one of the six selections after the first round and those who receive revenue sharing funds were entered into a second lottery for the six picks immediately following the second round of the Draft. A club's odds of winning the lottery were based on its prior season's winning percentage compared to other eligible clubs in that lottery round.
The Twins, along with the Mariners, were only eligible for Round B, as they both receive revenue sharing funds, but don't rank in the bottom 10 in market size or revenue. The Pirates, Rays and Royals were not selected in either round.
Competitive balance picks are also the only picks that can be traded before next year's Draft.
Rhett Bollinger is a reporter for MLB.com. Read his blog, Bollinger Beat, and follow him on Twitter @RhettBollinger. This story was not subject to the approval of Major League Baseball or its clubs.