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Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma
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|Diffuse Large B-Cell Lymphoma
|Drug: AEB071
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|An Open-Label, Single-arm, Phase I Study of AEB071 (a Protein Kinase C Inhibitor) in Patients With CD79-mutant Diffuse Large B-Cell Lymphoma
- Frequency of Dose Limiting Toxicity (DLT) during cycle 1 (Dose Escalation phase) [ Time Frame: Cycle 1 (28 days) ]
- Number of Pparticipants reporting Serious Adverse Events and Adverse Events (Dose Expansion phase) [ Time Frame: Baseline, 28 days ]
- Overall Response Rate, using NHLIWG criteria [ Time Frame: Baseline, 12 months ]Assess the overall response rate to AEB071
- Number of Participants reporting Serious Adverse Events and Adverse Events [ Time Frame: Baseline, 12 months ]
- AEB071 PK parameters including Cmax, tmax, AUCt, Ctrough, CL/F and RA [ Time Frame: First 7 months of treatment period ]Evaluate the single and multiple dose PK of AEB071 in patients with Diffuse Large B-Cell Lymphoma (DLBCL)
- Pre and post-dose gene and protein expression of cytokines and any correlations with exposure to AEB071 [ Time Frame: First 7 months of treatment period ]Assess the pharmacodynamic response to AEB071 in Lymphoma and blood specimens
|Study Start Date:
|November 2011
|Study Completion Date:
|April 2014
|Primary Completion Date:
|April 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: AEB071
|Drug: AEB071
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Diffuse large B-cell lymphoma (DLBCL) with activating mutations in CD79 (A or B subunits). DLBCL that arose from transformed indolent lymphoma is allowed.
Prior treatment and relapse following anthracycline-based chemotherapy and autologous bone marrow or stem cell transplant. Patients who are not transplant eligible may be considered for the study following a single regimen of chemotherapy such as R-CHOP or R-EPOCH alone. There is no limit to prior therapy allowed.
- Patients may be treated with localized radiation to as many as two sites of disease, so long as measurable or evaluable disease remains at untreated sites.
- Patients may be treated with corticosteriods immediately prior to enrollment and during the course of the study treatment as long as steriod treatment is tapered to a toal daily dosage of 10mg or less of prednisone (or it's equivalent) prior to AEB071 administration
- WHO performance status of ≤2
Exclusion Criteria:
- Patients at screening who are treated with strong inducers or inhibitors of cytochrome P450 3A4 (CYP3A4) that can not be discontinued.
- Impaired cardiac function or clinically significant cardiac diseases, including any of the following:
- History or presence of ventricular tachyarrhythmia
- Presence of unstable atrial fibrillation (ventricular response > 100 bpm); Patients with stable atrial fibrillation are eligible, provided they do not meet any of the other cardiac exclusion criteria.
- Angina pectoris or acute myocardial infarction ≤ 3 months prior to starting study drug
- Other clinically significant heart disease (e.g., symptomatic congestive heart failure; uncontrolled arrhythmia or hypertension; history of labile hypertension or poor compliance with an antihypertensive regimen)
- Patients with another malignancy that was treated within the last three years with the exceptions of localized basal cell carcinoma and cervical carcinoma.
- Patients with impairment of GI function or GI disease that could interfere with the absorption of AEB071.
Patients with a known history of Human Immunodeficiency Virus (HIV)
- HIV testing is not required as part of this study
Patients with a known history of active hepatitis B or C infection unless they are on antiviral therapy
- The determination of active hepatitis status should be as per standard of care at each site
- Hepatitis B and C testing is not required as part of this study
Time since the last prior therapy for treatment of underlying malignancy**:
- Cytotoxic chemotherapy: ≤ than the duration of the most recent cycle of the previous regimen (with a minimum of 2 weeks for all)
- Biologic therapy (e.g., antibodies): ≤ 4 weeks
≤ 5 x t1/2 of a small molecule therapeutic, not otherwise defined above
**Patients must have recovered or stabilized from all toxicities related to their previous treatment except for alopecia
- Patients with any history of significant coagulopathy or a medical condition requiring long term systemic anticoagulation that would interfere with biopsies.
- Patients having undergone major surgery less than 4 weeks prior to enrollment or that have not fully recovered from prior surgery.
- Pregnant or nursing (lactating) women
Other protocol-defined inclusion/exclusion criteria may apply
Please refer to this study by its ClinicalTrials.gov identifier: NCT01402440
Show 24 Study Locations
|Study Director:
|Novartis Pharmaceuticals
|Novartis Pharmaceuticals
|Study Director:
|Novarts Pharmaceuticals
|Novarts Pharmaceuticals
|Responsible Party:
|Novartis Pharmaceuticals
|ClinicalTrials.gov Identifier:
|NCT01402440 History of Changes
|Other Study ID Numbers:
2010-024367-41 ( EudraCT Number )
|Study First Received:
|July 5, 2011
|Last Updated:
|January 6, 2015
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Diffuse Large B-Cell Lymphoma,
Phase 1,
CD79 Mutation
Additional relevant MeSH terms:
Lymphoma, B-Cell
Lymphoma, Large B-Cell, Diffuse
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Lymphoma, Non-Hodgkin
ClinicalTrials.gov processed this record on September 18, 2017


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cousinbasil wrote:P.S. I think cousinbasil is really Danny Boy!
You caught me!
GodsDaughter says: What part of you did I catch?
Discussion of the nature of Ultimate Reality and the path to Enlightenment
cousinbasil wrote:P.S. I think cousinbasil is really Danny Boy!
You caught me!
cousinbasil wrote:Rodster wrote:How did I figure you were one-in-the-same? Easy. Another giveaway is your getting carried away with people's spelling (etc) errors. Both Brokie and Basil have hardon's over that.
Again, I can't speak for this other fine fellow Brokenhead, but I do get woody over people's spelling errors and substandard English usage. Like right here! It's not one-in-the-same, it's one-and-the-same. And "hard-on" has a hyphen.There's computer programs that decipher losers like you.
I am sure you meant there are programs...You know, I'm the one who busted Alex when he came back with a different "person" as he says that 'brokenhead' and 'cousinbasil' as different "persons" Your writing style cannot be hidden you overeducated jerk.
Roddy, the average household pet is overeducated compared to you. And lah-di-fucking-dah about busting Alex, let me FedEx you a cookie.As far as Roddy goes, I've admitted (way, way back .. years ago) in PMs to a couple folks here .. if they wanna get involved in it fine by me. Like I'm gonna ask Dan if I can "become Roddy" just to piss you off.
Whatever you say, Rodmeister. You seem pretty ornery yourself. I guess that comes with advanced age and lowered expectations. I wouldn't know.You're instigating Donna for your twisted mind don't deny it. She's having a tough go of it but you press her on in an insane thread. You loser.
Of course I deny that I am, but I can't say the same about you, with your heavy-handed unfunny "matchmaking" posts. By the way, who are you to impugn my intentions when I communicate to anyone else but you? You are one miserable old lout.
Tomas wrote:Tomas Note: Obama launched his re-election campaign on Karl Marx's birthday, May 5th.
Obama Campaign Vision Said Echoes Orwell's 1984
Obama '84: Echoes of Orwell
The calendar says 2012. The propaganda screams Nineteen Eighty-Four.
The Obama brain trust in Chicago recently rolled out its new campaign slogan: "Forward." If the president's most extreme detractors had wanted to give him a rallying cry more freighted with leftist baggage, they could not have done better.
Forward was the name of the socialist rag which Friedrich Engels and Leon Trotsky wrote. Forward was the name of the newspaper Vladimir Lenin founded, and it was at the heart of one of his most famous political slogans: "When one makes a revolution, one cannot mark time; one must always go forward - or go back." Stalin used the motto "Forward to communism!" Mao led the "Great Leap Forward."
The Obama campaign geniuses seem unfamiliar not only with modern political history, but also with George Orwell.
Then there is Julia. In Nineteen Eighty-Four, she is an enthusiastic propagandist for the Party, an eager participant in the daily "Two Minute Hate" of its enemies and eventually a victim of Big Brother's totalitarian cult of personality. In the Obama campaign's "The Life of Julia," she is the faceless protaganist of an interactive story demonstrating "how Obama's policies help one woman over her lifetime - and how Mitt Romney would change her story."
The Obama campaign presents "The Life of Julia" as a utopian fairy tale about a statist future. Others may recognize it as a dystopian horror story that breaks sharply from America's individualist past.
Full story here >> http://www.philly.com/philly/opinion/20 ... rwell.html

subset: commoncrawl


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TWO North Yorkshire teenagers are due in court after they were arrested for driving offences near Easingwold late on Tuesday evening.
Passers-by spotted the man and woman, both 18, in a car on the A19 near Shipton at about 10pm on Tuesday night, and called the police, worried about the way the car was being driven.
Police said they found the vehicle and the pair – the man from Malton and a woman from Easingwold – in Crayke, near Easingwold, and arrested both.
The woman was later charged with a driving licence offence, drink-driving, possessing a weapon designed to discharge an electrical incapacitant, and driving without insurance; while the man was charged with aiding and abetting a driving licence offence, failing to stop for police, obstructing or resisting a police office in the execution of duty, and driving without insurance.
Both will appear before magistrates in Northallerton in early September.


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penciclovir topical (generic name)
It is used to treat infections caused by certain kinds of viruses
(pen SYE kloe veer)
Table of Contents
Top Learning Centers(Recursos en Español)
What is this medicine?PENCICLOVIR (pen SYE kloe veer) is an antiviral medicine. It is used to treat infections caused by certain kinds of viruses. Examples of these infections include cold sores and herpes. This medicine will not cure herpes.
What should I tell my health care provider before I take this medicine?They need to know if you have any of these conditions:
How should I use this medicine?This medicine is only for external use on the lips or face. Do not use in the eye or inside the mouth. If you do get this medicine in your eyes, rinse out with plenty of cool tap water. Follow the directions on the prescription label. Wash your hands before and after use. Apply a thin layer of cream to cover all sores or blisters. Begin applying at the first sign of blisters or as soon as you have symptoms. Apply every 2 hours while you are awake or as instructed by your doctor or health care professional. Do not use your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
What if I miss a dose?If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
What may interact with this medicine?Interactions are not expected. Do not use any other skin products on the affected area without telling your doctor or health care professional.
What should I watch for while using this medicine?Even though you are using this medicine, you can still spread the herpes infection to another person. Try to keep the sores (blisters) from making contact with another person's skin.
This medicine works best when applied very early in the course of an infection. Begin treatment at the first sign of infection. These signs include tingling, itching, or pain in the affected area.
What side effects may I notice from receiving this medicine?Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
Where should I keep my medicine?Keep out of the reach of children.
Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not freeze. Throw away any unused medicine after the expiration date.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


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The RJ45 Cat 5e patch is perfect for use with 10/100 Base-T networks.
83-10681 - 6 ft USB 2.0 A/B Cable - Black
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831-5012 - RJ45 In-Line Coupler
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The PC screw kit is a handy assortment of common PC fasteners for building,
repairing, and maintaining computer systems.
The kit includes 12 different fasteners all in a plastic carrying case with divided compartments. Includes 50 screws and fasteners in each of...
Purchasing was easy, shipping was fast and the items were packed well.


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Last week we told you about paintings done by artist Brian Broadway of Blas Perez' late father and Bobby Rhine. This past weekend, the Rhine painting was installed in it's permanent home. Rhine's wife, Bevan Brooks Rhine, provides the update:
It was an honor to present this painting of Bobby to Coach Reid and the UCONN soccer department this past weekend. The really cool part is that they had Bobby's game jersey from that very photo and it's going to be hung next to the painting in the soccer offices. Very cool!!


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Tracy Reese Runway | Fashion Week Fall 2013 Photos
The 10 Best Looks Fresh From the Tracy Reese Fall '13 Runway
The 10 Best Looks Fresh From the Tracy Reese Fall '13 Runway
Tracy Reese celebrated the quintessential NYC girl today at her packed Fall '13 show. Complete with an asphalt runway, the designer focused her attention on feline prints — she even had a real cat on the runway — splashed on a multitude of biker jackets, trousers, and dresses. Reese's ladylike side came through in lace-embellished dresses with flowy, full skirts, while mini sequined shifts provided the party girls with something to wear come nightfall. See the top 10 moments from her collection now.
0previous images
-20more images


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Martin back in high spirits after tests show good news
ST. LOUIS -- Russell Martin was back in the Pirates' clubhouse Sunday morning, feeling better both physically and emotionally.
On the body side, pain in the left hip area deriving from having favored a strained left hamstring had subsided. On the soul side, an MRI confirming the hamstring as the only issue came as relief.
"The MRI just showed a strain in the hammy," said Martin, who went on the disabled list Saturday and also went to Pittsburgh for the medical evaluation. "With the hip [discomfort], I was probably complicating things trying to take away some of the pain from the hammy. The only thing sore now is the hammy."
Martin received a platelet-rich plasma injection, and will rest for a few days before beginning a rehab routine laid out by head athletic trainer Todd Tomczyk.
The veteran said he has dealt with the hamstring discomfort since the onset of Spring Training.
"Even coming into Spring Training, I felt there was some tightness," Martin said. "I didn't know the severity, but I managed it pretty well through Spring Training. You don't play every day, and you don't play nine innings, so you can grind through it."
Martin sensed he was in serious trouble on April 19, when he tore down the first-base line for an infield single after lining a ball off Milwaukee pitcher Rob Wooten -- and three pitches later raced home on a double by Andrew McCutchen.
"I knew something was wrong, that I'd re-tweaked it pretty badly," said Martin, noting that since the mere act of checking swings had been excruciating. "I would really feel a jolt. With every checked swing, it would get worse and worse."
Tom Singer is a reporter for MLB.com and writes an MLBlog Change for a Nickel. He can also be found on Twitter @Tom_Singer. This story was not subject to the approval of Major League Baseball or its clubs.


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It's a pretty good bet that Calgarians who lived 100 years ago would never have imagined there'd be a restaurant in the saddlery on Stephen Avenue Walk.
But today, the renovated building is home to Blink Restaurant and Bar, an intimate space that serves up inspired food made with local ingredients. There's not a saddle in sight, but there are 62 seats (plus more at the bar) for diners who are looking for a night out dining on contemporary food in an atmosphere that's both rustic and modern.
Blink is open for lunch and dinner, as well as "late night" on Fridays and Saturdays, where you can stop in for appetizers, dessert, and a drink. The restaurant's wine list features selections from family-run wineries in California, the Pacific Northwest, Canada, and Europe.
- 100% Non-smoking
- 64 seats
- Bring your own wine
- Casual dining
- Corkage fee
- Debit Card/Interac
- Dinner Entree: $30 to $39
- Eco-friendly
- Energy conservation
- Family friendly
- Group seating
- Licensed
- Meeting rooms
- OpenTable online reservation
- Organic produce
- Recycle
- Reservations recommended
- Seasonal outdoor patio
- Source local produce
- Visa
- Wheelchair access


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The Mantua Adjustable Bed Frame Fits Any Size Mattress for Usefulness and Versatility The Mantua universal bed frame is a lightweight and basic metal bed frame that adjusts to fit any size bed from twin to king. It makes a great frame for a child's room as it can grow with the child to fit increasingly larger mattress sets. This item is highly portable, and it disassembles easily for space-saving storage when not in use. The Mantua universal frame is a flexible and convenient, space-saving item that's durable enough to last for years of use. The Mantua adjustable bed frame is a no-frills piece of furniture that packs a lot of function into a minimal space. The frame slides to expand from a twin to up to a king size in seconds and bolts securely into place once adjusted. The L-shaped side rails hug the base of the box spring for a secure fit. The headboard brace adjusts to accommodate any size headboard. The central stability bar prevents sagging and features wide, flat feet to keep the bed from sliding on bare floors. The corner-mounted roller wheels have 360-degree turning ability and allow the bed to be moved easily when rearranging the room or for under bed cleaning.
- The Mantua universal bed frame is crafted of all metal that is lightweight but durable, for years of use
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- Measures 76"w x 70"l x 74" h and weighs only 36 pounds
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Geez...I got sick and tired of every call and email on the Jim Rome show today being about Boston. So what, they finally got a radio station in town to carry Rome's show.
I know that the world doesn't revolve around Indiana, but during the times that I listened in to a FREAKING SPORTS SHOW, Boston was the topic about 90% of the time.


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Good day,
I am developing a bookstore website using PHP/MySQL. I have set some tables in MySQL and I'd like to ask about key constraints.
I created some testing tables I to define how to set key constrains:There are two parent tables with one primary key each and no foreign keysThere is one child table with no primary key and two foreing keys, one from each parent table.I'd like to be able to load .csv files using MySQL importing feature in all three tables, and also delete/change information from each of them.
Here my questions:Should I define key constraints in both parents and child tables?What should I set in each case for ON DELETE and ON UPDATE?
Thanks a lot!!
no, only in child tables
for the time being, don't bother with this part, leave it out and let it use the defaults
if you are just learning, the main thing is to see how a foreign key works "out of the box"
for example, if a parent row has one or more child rows, and you try to delete the parent row, what normally happens is that it won't let you do that, because the child row would then be an orphan, its foreign key to the parent row would be invalid
this is called relational integrity
there are options to override the "out of the box" behaviour, but you don't need to learn them yet
Thanks a lot for your answer!
When you say:"for the time being, don't bother with this part, leave it out and let it use the defaults"
Do you mean I should not define any key constrain? (I guess I should. If not, how could I set the relationship)Or do you mean I should set ON DELETE no action and ON UPDATE no action? It also gives me "castade", "set null" and "restrict" options.
no, you should
i'm saying omit those, and let them take whatever the default is
exactly where do you see these options?
I am working in CPanel, phpMyAdmin. Select database, select table, select "structure" tab and then press "Relation view" button to see Relations page.
darn it holmes, just as i feared -- learning how databases work via the phpmyadmin ptui user-friendly interface
choose the RESTRICT option, because that's mysql's default
Understood, thanks!
One last question. These three sample tables contain static information, it is, not updated by the website when in use. Just to read from them.If I wanted to change something in one of the parent tables, I will be restricted by the relationship with the child table. How could I do it?
this is true ~only~ if you are trying to update or delete the value of a primary key column -- all other changes to the parent table are okay
Thanks a lot!!!


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Cabers likes to do the prediction contests too
"I'm so damn good when I'm finished there won't be a dry eye - or dry seat - sorry ladies - in the entire arena." #HEEL
Last edited by NiallF96; 01-21-2013 at 05:49 PM.
Chris Diamond
IWA Endurance Champion
Antonio Rizzo
Chaos Roster member
Head of IWA Chaos
Wade Barrett
Former Member of the United Kingdom stable
Daniel Bryan


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Apple (AAPL) is a terrific company. I have been behind the stock for ages. There will be people who question my "devotion" to Apple. Some are critical that, after Steve Jobs died, I said it was just another stock -- as if it could actually be the same company without him. No one in business ever says it's the same after a founder dies, but that's what I have been criticized for endlessly, because the stock climbed after his passing.
It was as if, when I said Apple was "just another stock," that this meant to sell and short the stock.
That's what happens when a cult surrounds a stock -- a cult of the lesser-informed. I am sure, as well, that the cult will be plenty angry about the stories involving Apple cutting orders for iPhone 5 parts, something that had been in the air just last week.
I want to talk about something else, though: a change in sentiment that may be behind the order-cutting.
Not long after that, we had begun to hear issues with the new iPhone and Apple Maps. I am always willing to consider an upgrade, even though I love my 4S. However, one of my favorite iPhone features is the blue-dot-red-dot, the map software that shows where you are vs. where you are going -- which Google (GOOG) provides to Apple. I hadn't wanted to lose that functionality -- which, at the time, would have been lost in an upgrade to the new iOS 6 operating system. I am also stuck, every day, carrying a heavy power cord for my Hewlett-Packard (HPQ) machine that The Street provides. I also keep a lighter charging cord for the iPhone and my iPod. The heck with carrying still one more power cord.
So I passed. But I defended Apple on air as a good company, because it owned up to its mistakes not long after, and that's what good companies do.
Then, soon after the flap, I met with Walter Isaacson, the great Jobs biographer, at a fundraiser for Bucknell University in the fall of last year. I wrote here that, one year after Jobs' death, Isaacson was worried there were no more "OMG" products on the drawing board -- that Jobs had left some good ideas behind, but nothing "wowing," and that this might crimp Apple's development over time.
Given that Isaacson spent hundreds of hours with Jobs in that last year of his life, I regarded this as meaningful insight.
It was especially eye-opening when Walter was asked about the coming of the Apple TV. He said an Apple television with voice-command precision would require the cooperation of cable companies, companies that are strong and very profitable -- quite different from weaker companies that Jobs "rolled with," like Sony (SNE), when he was building out iTunes.
To me that was enough. After sharing this view with Action Alerts Plus subscribers, we sold some Apple and cut the position in half.
This was the moment I started feeling the real wrath of the cult of Apple. Suddenly I was no longer the guy who liked it at $50. I was the guy who hated it at $480, after Jobs' death, when it became just another stock, and then loved it at $700 because of the new iPhone, and then didn't like it at $600.
Suddenly I was an Apple fool.
To me it all seemed a little ridiculous. I had a fabulous gain for my trust, and I kept it even after Jobs died, despite my recognition that Apple couldn't be as good without him.
Then I was enthusiastic about the iPhone launch, but was made less enthusiastic by the Maps flap. Then I felt gut-punched by the Isaacson meeting, and felt the need to cut it in half and play with the house's money, just as my rules always say to do.
During this period Apple missed estimates for two quarters in a row and, in rather dramatic fashion, Samsung exceeded it in overseas smartphone sales. I was willing to overlook those quarters and the Samsung surge. As we all know, Apple's stock is inexpensive, and the company is hugely profitable, even if it doesn't beat the estimates.
Here, and on the air, I have always say the same thing. You can't trade Apple. I own it as an investment. It is too hard to trade, too caught up in emotion.
That leads me to why I am talking about this at all.
On Friday night, my daughter -- one of the big drivers of why I ever liked the stock in the $50s -- texts me and says, "You have to go to someone at Apple. I hate the new iTunes software." I text her back saying that I, too, hate it, and that I'd ask her for help with it. Then she texts back, "All my friends hate it."
I thought that I'd better keep that to myself -- the Apple cult will kill me, because they will want to know why I didn't say anything about this at $700 or at least $600. I even thought about the idea of time-stamping my daughter's complaint so I could defend myself against the cult's anger.
I had already been lambasted on Twitter @jimcramer for nodding my head when David Faber, after a return from Europe, said he saw Samsung phones everywhere.
Then, this Saturday, I decided it was time to get my new iPad mini hooked into a Verizon (VZ) plan so it wasn't bound just by Wi-Fi. Yes, I still love the products -- and I love this device, love its size.
I always use the same Verizon reseller in the city. Sure enough, I tell him about my daughter's comments. He knows we are huge Apple fans. He says more people now want Samsung because it is a better product, that it has better specs.
Now, he knows, one, that I have an iPad mini and an Apple iPhone. Two, he knows I am not out to buy another phone, that he has nothing to gain by telling me this. Three, he knows I am a huge Apple supporter on air.
I tell him Apple is still a great company. He says Samsung is now better, and that it's so much easier to deal with. I know the sales incentives are better for Samsung -- I've seen that enough times in testimonials on Twitter. But my guy simply says, "Look, Apple's got some great features, but it is not so much better than Samsung all around anymore. It just isn't. Not for the price."
I won't identify him for fear of the Apple cult. You can't be honest; the cultists could wreck your business.
So now I am thinking, what do you do? There were so many buyers in the $500s and $600s, and in that brief spike to $700, who now are hanging on -- furious at themselves, furious at me, furious at anyone who for a minute says anything negative. There are other people who insist on asking, almost daily, "Jim, so would you trade it? Would you sell it? Would you short it?" and I hear their questions and I think: What's the point? I own it for the charitable trust, I am playing with the house's money and I am not going to trade it. Period.
I know that, if Apple misses the quarter, it will be the third straight miss. I have a personal rule not to stick with a company that misses this much. But if it does miss, the stock will go to the $400s, and if I invoke my personal rule it will be, "He told us not to trade it or sell it at $520, and now he says sell it at $420," where I bet it will go. If they make the quarter, or blow it away, it might go to $580 and people will say, "Why didn't he tell us to buy it?"
Frankly, at this point Apple's become too hard to fathom. It is gigantic in market capitalization, far more than others. It has to do things no other company could possibly do to keep up that growth, including investing in OMG products, without the man who invented so many of those products that are still there.
Who needs this pressure?
I can stand here and say I wish I'd said to sell it at $700, but that was before some of the most important things that could happen at a company: (1) The ramifications of a second quarterly miss; (2) the Maps flap and (3) the Isaacson revelations. I didn't have those things in hand -- like (4) the hated iTunes release -- things that I don't believe would have happened if Jobs had lived.
In my view, I've handled this wild tiger of a stock about as best as I can. But the cult has been murderous. So I sit back, content to play with the house's money.
But I'm worried -- worried that Apple just isn't as good as it used to be, and that my formerly Apple- loving, now Apple-hating daughter wouldn't have texted me that she's furious at the company and is wondering why it's making all of these stupid moves. "They are arrogant, Dad. And I just don't like them anymore," she lectured me at dinner Saturday before returning to school. That's coming from someone who convinced me to recommend the stock seven years ago. So let's just say this: Cultists, and non-cultists, you just can't blame me for being critical, worried and, alas, less positive on the stock that defined the market for oh so many years.


text: Symptoms and causes By Mayo Clinic Staff Print SymptomsIf your baby is born with pulmonary atresia, symptoms will be noticeable soon after birth. Pulmonary atresia symptoms may show up within hours to several days. Your baby's signs and symptoms may include: Blue- or gray-toned skin (cyanosis) Fast breathing or shortness of breath Easily tiring or being fatigued Feeding problems, such as tiring or sweating while eating Pale, clammy skin that may feel cool to the touch When to see a doctor Your baby will most likely be diagnosed with pulmonary atresia within the first few hours to the first few days of life. However, if your baby has any symptoms of pulmonary atresia after you've returned home, seek emergency medical attention. Causes Chambers and valves of the heartChambers and valves of the heartA normal heart has two upper and two lower chambers. The upper chambers, the right and left atria, receive incoming blood. The lower chambers, the more muscular right and left ventricles, pump blood out of your heart. The heart valves, which keep blood flowing in the right direction, are gates at the chamber openings. Pulmonary atresiaPulmonary atresiaIn pulmonary atresia, the valve that lets blood flow from the heart to the lungs isn't formed properly. Instead, some blood may reach the lungs via a temporary connection (ductus arteriosus) between the baby's aorta and the pulmonary artery. Some babies born with pulmonary atresia may have a small (hypoplastic) right ventricle. There is no known cause of pulmonary atresia. It's thought that the problems that cause pulmonary atresia begin early in the pregnancy. To understand the problems pulmonary atresia causes, it's helpful to know how the heart works. How the heart works The heart is divided into four hollow chambers, two on the right and two on the left. In performing its basic job — pumping blood throughout the body — the heart uses its left and right sides for different tasks. The right side of the heart moves blood to the lungs through vessels called pulmonary arteries. In the lungs, blood picks up oxygen then returns to the heart's left side through the pulmonary veins. The left side of the heart then pumps the blood through the aorta and out to the rest of the body to supply your baby's body with oxygen. Blood moves through your baby's heart in one direction through valves that open and close as the heart beats. The valve that allows blood out of your baby's heart and into the lungs to pick up oxygen is called the pulmonary valve. In pulmonary atresia, the pulmonary valve doesn't develop properly, preventing it from opening. Blood can't flow from the right ventricle to the lungs. Before birth, the improperly formed valve isn't life-threatening, because the placenta provides oxygen for your baby instead of the lungs. Blood entering the right side of your baby's heart passes through a hole (foramen ovale) between the top chambers of your baby's heart, so the oxygen-rich blood can be pumped out to the rest of your baby's body through the aorta. After birth, your baby's lungs must provide oxygen for his or her body. In pulmonary atresia, without a working pulmonary valve, blood must find another route to reach your baby's lungs. The foramen ovale usually shuts soon after birth, but may stay open in pulmonary atresia. Newborn babies also have a temporary connection (ductus arteriosus) between the aorta and the pulmonary artery. This passage allows some of the oxygen-poor blood to travel to the lungs where it can pick up oxygen to supply your baby's body. The ductus arteriosus normally closes within a few hours or days after birth, but can be kept open with medications. In some cases, there may be a second hole in the tissue that separates the main pumping chambers of your baby's heart, called a ventricular septal defect (VSD). The VSD allows a pathway for blood to pass through the right ventricle into the left ventricle. Children with pulmonary atresia and a VSD often have additional abnormalities of the lungs and the arteries that bring blood to the lungs. If there's no VSD, the right ventricle receives little blood flow before birth and often doesn't develop fully. This is a condition called pulmonary atresia with intact ventricular septum (PA/IVS). Risk factorsIn most cases, the exact cause of a congenital heart defect, such as pulmonary atresia, is unknown. However, several factors may increase the risk of a baby being born with a congenital heart defect, including: A mother who had German measles (rubella) or another viral illness during early pregnancy A parent who has a congenital heart defect Drinking alcohol during pregnancy Smoking before or during pregnancy A mother who has poorly controlled diabetes A mother who has lupus, an autoimmune disorder Use of some types of medications during pregnancy, such as the acne drug isotretinoin (Claravis, Amnesteem, others), some anti-seizure medications and some bipolar disorder medications The presence of Down syndrome, a genetic condition that results from an extra 21st chromosome ComplicationsWithout treatment, pulmonary atresia is nearly always fatal. Even after surgical repairs, you'll need to carefully monitor your child's health for any changes that could signal a problem. People with structural heart problems, such as pulmonary atresia, are at a higher risk of infectious endocarditis than the general population. Infectious endocarditis is an inflammation of the valves and inner lining of the heart caused by a bacterial infection. Request an Appointment at Mayo Clinic OverviewDiagnosis Aug. 04, 2017 Print Share on: FacebookTwitter References Facts about pulmonary atresia. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/heartdefects/pulmonaryatresia.html. Accessed Oct. 28, 2015. Single ventricle defects. American Heart Association. http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/Single-Ventricle-Defects_UCM_307037_Article.jsp#.VjE3ztiFOic. Accessed Oct. 28, 2015. Axelrod DM, et al. Pulmonary atresia with intact ventricular septum (PA/IVS). http://www.uptodate.com/home. Accessed Oct. 28, 2015. Congenital heart defects. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/health-topics/topics/chd#. Accessed Oct. 29, 2015. Congenital heart defects: Tracking and research. Centers for Disease Control and Prevention. http://www.cdc.gov/ncbddd/heartdefects/research.html. Accessed Nov. 20, 2015. Congenital heart defects and CCHD. March of Dimes. http://www.marchofdimes.org/baby/congenital-heart-defects.aspx. Accessed Nov. 20, 2015. Isotretinoin and other retinoids during pregnancy. March of Dimes. http://www.marchofdimes.org/pregnancy/isotretinoin-and-other-retinoids-during-pregnancy.aspx. Accessed Nov. 20, 2015. Perloff JK, et al. Pulmonary atresia with intact ventricular septum. In: Perloff's Clinical Recognition of Congenital Heart Disease. 6th ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.clinicalkey.com. Accessed Nov. 23, 2015. Kouchoukos NT, et al. Pulmonary atresia and intact ventricular septum. In: Kirklin/Barratt-Boyles Cardiac Surgery. 4th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www.clinicalkey.com. Accessed Nov. 23, 2015. Geggel RL. Diagnosis and initial management of cyanotic heart disease in the newborn. http://www.uptodate.com/home. Accessed Nov. 23, 2015. Park MK. Cyanotic congenital heart defects. In: Pediatric Cardiology for Practitioners. 6th ed. Philadelphia, Pa.: Mosby Elsevier; 2014. http://www.clinicalkey.com. Accessed Nov. 23, 2015. Hay WW, et al. Cardiovascular diseases. In: Current Diagnosis & Treatment: Pediatrics. 22nd ed. New York, N.Y.: McGraw-Hill Education; 2014. http://www.accessmedicine.com. Accessed Nov. 25, 2015. Your child's special needs. American Heart Association. http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/CongenitalHeartDefectsToolsResources/Web-Booklet-If-Your-Child-Has-a-Congenital-Heart-Defect_UCM_316608_Article.jsp#.VlYG3diFOic. Accessed Nov. 25, 2015. Riggen EA. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Oct. 20, 2015. Taggart NW (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 6, 2016. RelatedPrenatal vitamins and pregnancyPregnancy and diabetesEchocardiogramX-rayShortness of breathFatigue Mayo Clinic in Minnesota has been recognized as one of the top Cardiology & Heart Surgery hospitals in the nation for 2017-2018 by U.S. News & World Report. Learn more about this top honor Pulmonary atresiaOverviewSymptoms & causesDiagnosis & treatmentDiagnosisTreatmentDepartments & specialtiesExpertise & rankingsLocations, travel & lodgingResearchCosts & insurancePreparing for your appointmentSelf-managementMore aboutIn-DepthMultimediaNews from Mayo Clinic Advertisement Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Advertising & Sponsorship Policy Opportunities Ad Choices Mayo Clinic Store Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. The Last Diet You'll Ever Need4 Simple Steps to a Joy-Filled LifePain Management Strategies from Mayo ClinicStop Osteoporosis in its TracksProtect and Preserve Your Vision Diagnosis & treatmentRequest an AppointmentDiagnosisTreatmentDepartments & specialtiesExpertise & rankingsLocations, travel & lodgingResearchCosts & insurancePreparing for your appointment CON-20155225 Patient Care & Health Information Diseases & Conditions Pulmonary atresia


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|Welcome to ETSU's
Buc Path to College Success!
Goals, Support and Involvement
The Buc Path is a series of visual timelines which highlight the
Use Buc Path as a guide to know when key academic requirements are due,
Begin using the Buc Path by clicking on the appropriate timeline for your classification ( first year, second year, etc.) located in the left navigation of this page. Use the horizontal scroll bar in each timeline to move the timeline left and right. Click on the timeline marker or text to get details and helpful information.
Each Buc Path Timeline contains three types of events:
Experiences that get you out of your comfort zone and stretch your knowledge, skills and abilities. The academic goals necessary for a timely graduation.
Assistance you need from staff and faculty to navigate university life and the career and personal choices you have to make along the way.
Exceptional opportunities to be involved outside the classroom, to put your learning into practice and to give back to the community.


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Two powerful prawn weapons...
For a great selection of film, comic and TV action figures and collectibles, check out BigBadToyStore.com, BriansToys.com, ToyWiz.com, PastGenerationToys.com, MonkeyDepot.com, and YesAnimation.com.
For a great selection of film, TV and pop culture t-shirts and apparel, check out TShirtGurus.com and 80sTees.com.
As previously reported, WETA Workshop had announced that they will be producing collectibles from the hit sci-fi movie District 9. WETA, which designed the original props for the film, reveals today their first two collectible offerings. These include two powerful prawn weapons: the ARC GENERATOR (pictured above) and the GAS PROJECTOR (below).
Both prop replicas are constructed of fiberglass (approximately 11 pounds)with assorted materials for the details. Each also comes with a wall mounting bracket for display. These amazing rifles are strictly limited to 200 pieces each. WETA is now accepting pre-orders at wetanz.com, each rifle replica priced at $710.22 NZD (approximately 485.75 US).
PLEASE NOTE: Unless your genetic makeup is part prawn, you cannot power up or fire these guns.


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I'm bored, so I'm fishning and haven't seen this...
Artest + Tinsley for Magette + Livingston.
We end up with a point gaurd that will play some this year and trade a malcontent that won't play for a pretty good player that MAY not play until next year.
They get a lot...if they can keep them on the floor.
(Yes it's acceptable with RealGM


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Skip to Content
Ronald Anderson, professor of education at the University of Colorado at Boulder, has been elected chair of the education section of the American Association for the Advancement of Science.
The AAAS is the world's largest general science organization with 144,000 members divided into 24 academic disciplines, one of which is education.
Anderson will serve one year as chair-elect of the education section beginning Feb. 19, a second year as chair and the third year as past chair and a AAAS council delegate. He will begin the sequence following the annual AAAS meeting in Seattle Feb. 13-18.
Anderson has been a CU-Boulder faculty member since 1965 and specializes in science education. From 1991 to 1995 he directed a national $690,000 study on curriculum reform funded by the U.S. Department of Education.
He is a former president of both the National Association for Research in Science Teaching and the Association for the Education of Teachers in Science. He also is an elected fellow of AAAS.
This year's annual AAAS meeting will mark the end of a year as chair of the psychology section for Alice Healy, CU-Boulder professor of psychology. One of the main responsibilities of AAAS section chairs is to organize sessions for their disciplines at the annual meetings.
The official research journal of the AAAS is the journal Science.


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We are in need of Fosters and Volunteers. If you are not sure if you want a life time commitment please consider fostering. We also need volunteers to help at adoption events. If you are interested in adopting, fostering, or volunteering please contact us. Thank you for helping us save one life at a time.
Thank You!
Your message has been sent to Furgotten Friends Dog Rescue.
You'll receive a copy, too, at to help you keep track of which pets you've inquired about, and which shelters and rescues you've emailed.
NOTE: Some shelters have physical locations you can visit; some of these shelters may only have pets for a limited time, so please do not wait for a reply—just go visit the shelter! Other organizations are rescue groups run by busy volunteers who may take a while to reply. You can find information about the shelter or rescue group caring for this pet, and their adoption procedures, on the pet's details page on Adopt-a-Pet.com.


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Topic: Update
Some of you will know about my family history and the incidence of cholangiocarcinoma (which killed my faather and eldest brother). Most family members hve colon cancer first and cholangiocarcinomac later on.
My other brother John was diagnosed with colon cancer on saturday after a colonoscopy. They are doing a ct scan this week to see if it has spread anywhere. He had his gall bladder out a year ago and i am hoping that they didn't miss anything back then... and that they haven't got his treatment hopelessly wrong...
Yours prayers and support are valued tremendously.


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How does that make any difference at all?
"Freedom is nothing else but a chance to be better." - Albert Camus
"Appreciation is a wonderful thing. It makes what is excellent in others belong to us as well." - Voltaire
"Everyone's values are defined by what they will tolerate when it is done to others." - William Greider
Last edited by vnzla81; 01-17-2012 at 05:50 PM.
So yeah, about those injuries...
Foster out 2 weeks with back procedure
By Conrad Brunner | Jan. 17, 2012
The Pacers will play the rest of this month without Jeff Foster.
Coach Frank Vogel broke the news today after practice.
"Jeff is going to be out for two weeks," he said. "He's having a procedure done to his back and he's not going to be with us for two weeks."
In that span, the Pacers play eight games, six on the road. Lou Amundson will step into the backup center role with support from Jeff Pendergraph.
"Right now it's Lou," Vogel said. "(Pendergraph) is finally healthy and able to contribute and we'll use him if we need him but Lou's a little further along with his conditioning and knowing the system and everything."
Foster, who turned 35 Monday, has appeared in five games this season averaging 16.8 minutes, 3.0 points and 4.6 rebounds. He has been bothered by back problems the past three years, missing 66 games in 2009-10, 26 last season and the first six this season.
Vogel said the Pacers would miss is leadership, experience "and toughness."
"He just changes the physicality every time he steps on the court," Vogel said.
I just don't see it. Granted, he hasn't had much playing time, but what I have seen when he is out there is alot of hustle and not knowing what to do with the basketball. Like getting a good offensive rebound and going back up 1vs3 and getting it blocked or airballing it off the backboard.
I have yet to see him pass the ball after coming up with it on a hustle play and every time it results in a horrible point blank brick shot or a turnover.
I probably shouldn't be so harsh with such a small sample size. I will try to give him a fair and fresh look on the road trip.
Yeah, somehow I doubt he'll be back in game action after two weeks.
I would be fine with this if Lou actually knew his role on offense. He tries to do too much and is far too erratic for my liking.
Is Joel Przybilla still out there somewhere. He'd be a good pickup if he's not retired for good. I'm not sold on Lou being a adequate backup C.
I think Pendergraph is going to be decent if he gets healthy and some playing time.
We can always go small for stretches with Danny at PF. Not ideal, but with our tough defense style it should work better than going "JOB small".
Last edited by Hoop; 01-17-2012 at 06:53 PM.
"Just look at the flowers ........ BANG"
we're playing with fire here, not having a decent backup C. I just don't get why we don't have a full roster?? this isn't nba2k
Didn't we just read an article about how the Pacers were going to play all out because there's plenty of guys on the bench ready to go when the starters get winded? Whoops.
I'll say it, since Mackey is showing admirable restraint:
I wish we'd signed Josh McRoberts.
This space for rent.
I was going through the Team salaries and looked at those Teams at or over the Salary Cap that have some depth at the Center position that maybe interested in dumping some salary.
The only 2 Players that I could come up that would make any kind of sense in looking to acquire ( using our Capspace ) is Nazr Mohammed with the Thunder and Robin Lopez with the Suns.
The Thunder have $60.7 mil in 2011-2012 salary where Nazr Mohammed has a $3.75 mil 2011-2012 Expiring Contract.
The Suns have $65 mil in 2011-2012 salary where Robin Lopez has a $2.86 mil 2011-2012 salary and will be a RFA in the 2012-2013 season. I'd even see if we could take on Grant Hill to add some SF / Veteran depth along with Lopez IF they are really desperate to shed salary
Another less palatable option is Johan Petro with the Nets whose owed $3.25 mil in 2011-2012 season and $3.5 mil in the 2012-2013 season. They are desperate to clear Capspace and was offering a 1st with Morrow. I'm sure that if the Pacers were interested in Petro...they could get a 1st round pick out of it as well. But my reaction to this is the same as yours when it comes to Petro....
Last edited by CableKC; 01-17-2012 at 09:17 PM.
Ash from Army of Darkness: Good...Bad...I'm the guy with the gun.
Lou Amundson is a perfect backup center. In fact I will say he is the absolute perfect person for this team because he is willing to not play when Foster is available.
Ryan Hollins is a Center at 7' & 240#. Cavs aren't playing him as he's only been in 4 games this year. He is a 2.5 mil expiring. In 010 with Minnie, he shot 56% FG and 60% FG with Cavs last season. He shoots 3-4 FGA per game. Shoots around 68% FT. I remember him starting some in Minnie and last year with the Cavs. I don't recall how good of a "D" player he is. I wouldn't believe he'd cost the Pacers, but a 2nd and some cap at the most. Might be someone to consider.
Quick... Someone call Greg Ostertag down in the D-league.
He's got PLENTY of experience!
...Still "flying casual"
Of course that is assuming it's monopoly money and there's plenty more where Jeff's 3mil came from. ...Because besides the cap there's also the idea of a budget.
Nuntius was right for a while. I was wrong for a while. But ultimately I was right and Frank Vogel has been let go.
"A player who makes a team great is more valuable than a great player. Losing yourself in the group, for the good of the group, thats teamwork."
-John Wooden
All there are is some sentences in a quote box. Don't know who said it, don't know when they said it, nor do we know where they said it.
You did this.


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Wheeler's 10 K's, Campbell's blast lift Mets
Righty turns in ninth straight quality start; left fielder hits three-run shot
NEW YORK -- When the Mets cut ties with Chris Young and called up Matt den Dekker last week, they did so with clear intent: Give the younger outfielder a shot in the Majors. den Dekker was demolishing Pacific Coast League pitching, and the organization had long thought highly of his glove, so it was time to see what he could do.
The secondary benefit concerned Eric Campbell, who has consistently produced since his May callup, but rarely got the chance to do so given the glut of outfielders and corner infielders on the Mets' roster. Campbell would get a chance to play against lefties regularly.
Friday night at Citi Field, with a southpaw on the mound in the form of the Cubs' Travis Wood, that secondary benefit became the primary one for the Mets. Campbell's three-run homer in the fourth inning gave them a permanent lead in a 3-2 win, the opener of a four-game series. It was a refreshing change of pace for New York after getting swept by the National League East-leading Nationals earlier this week.
"[Wood] was struggling with his command that inning, so I figured if he's going to throw a strike, it's probably going to be something toward the middle, just trying to get one over. And he did," Campbell said of his game-winning homer. "He left one out over the plate and I got the barrel out there."
It was Campbell's second hit in 17 at-bats on the month and his first home run since May 21. David Wright and Lucas Duda both drew walks and scored on the long ball that landed in the Party Deck in left field.
"Walks killed me. If you take out half the walks, it'd be a pretty solid game," Wood said. "That was the game. I had the two walks to start the fourth and the guy [Campbell] hit the ball out of the park. I gave up four hits, and one of them happened to be a long ball with two walks and that was the game."
Right-hander Zack Wheeler and the Mets' bullpen took it from there. Wheeler lasted 6 2/3 innings, striking out 10 -- including five in the first two innings -- while allowing two runs on four hits and four walks.
Wheeler's 120 pitches were a career high, and he made it through his last 3 2/3 innings without allowing a hit after early trouble. The Mets' late-inning triumvirate of Vic Black, Jeurys Familia and Jenrry Mejia kept Chicago hitless the rest of the way.
For Wheeler, it was the latest in a series of successful starts in what is becoming an impressive sophomore campaign. He owns a 2.02 ERA in his last nine games, a stretch of quality starts in which he has allowed more than two earned runs just once.
That streak appeared to be in danger when Wheeler found himself at 59 pitches through three innings. Then he settled down.
"[Wheeler] can overpower some teams," Mets manager Terry Collins said. "He was throwing the ball very well early. He got some strikeouts early, and I think he went back to pitching to contact where he got some easier outs. He got some outs with two and three pitches as opposed to seven."
Wheeler said he indeed made more of an effort to pitch to contact, so he had a better chance of lasting longer.
"Obviously everybody knows my pitch count is always high," Wheeler said. "I always try to pitch to contact early, but sometimes I catch myself trying to do too much sequence-wise or command-wise. So sometimes you'll catch yourself with a lot of pitches at the beginning of the game, so you try to pitch a little more to the outer and inner thirds instead of just the corner."
The Cubs reached Wheeler for a pair of runs in the third. When Javier Baez -- Chicago's rookie sensation -- singled to center, Wood tested Juan Lagares' arm and safely went from first to third. Anthony Rizzo grounded out to plate Wood, and Starlin Castro singled to bring Baez home.
Wheeler escaped that frame without further damage an inning after striking out the side when the Cubs put their first two batters on.
For Collins, that is a tangible sign of growth from Wheeler, who might not have reacted in the same fashion as a rookie a year ago.
"That's what he can do," Collins said. "He'll get in a jam, and he'll all of a sudden take over the inning. A year ago, he would try to maneuver his way through. He just said, 'Listen, I may not be here in the seventh inning, but they're not scoring this inning' and take over the inning and dominate it and get some strikeouts and get out of it."
Tim Healey is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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For years, Senate Democrats have advocated for a refocused commitment to the mission in Afghanistan – the central front in the fight against al Qaeda. While the White House and its Republican allies have continued to divert critical resources away from the campaign in Afghanistan in support of its endless war in Iraq, Senate Democrats have consistently worked to sustain our focus on winning the battle against the Taliban and al Qaeda terrorists that attacked our country on 9/11.
Democrats Fight for Smart Change in Strategy; Republicans Sit on Sidelines
At nearly every turn, Democratic efforts to right our course in Afghanistan have been thwarted by the Bush Administration and Congressional Republicans. At a direct cost to our mission in Afghanistan, Bush Republicans have poured nearly four times the funding and troops into a war of choice in Iraq, leaving the fight to secure Afghanistan and combat the resurgent Taliban and al Qaeda under-resourced and largely neglected. Since the start of the war on terrorism in October 2001, the Administration has provided $172 billion for efforts in Afghanistan and the global war on terror, while allocating more than $650 billion for operations in Iraq over the past five years.
Even as the situation in Afghanistan has deteriorated, Bush Republicans have kept that campaign a second-tier priority. In December 2007 testimony, Admiral Mike Mullen, Chairman of the Joint Chiefs, underscored the impact of the Bush focus on the war in Iraq over our efforts in Afghanistan. While noting that violence in Afghanistan had risen 27 percent from a year ago and the increased infiltration of foreign militants and al Qaeda terrorists into the country, Mullen stated that Afghanistan remained "an economy of force operation… In Afghanistan, we do what we can. In Iraq, we do what we must." (House Armed Services Committee Hearing, 12/11/07)
The results of this strategic failure have been devastating for U.S. national security:


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NEW YORK (AP) - U.S. carriers have started nailing down the release dates and prices of Samsung's new flagship phone, the Galaxy S 4.
AT&T Inc. has started taking pre-orders, and says phones will be shipped starting April 30. It's charging $200 for the base model, with 16 gigabytes of memory, under a two-year contract. Staples says it will start selling the AT&T model on April 26.
Sprint Nextel Corp. starts taking pre-orders Thursday, and says in-store sales start April 27. It charges $250 for the base model, or $150 if the buyer is coming over from another carrier
T-Mobile USA starts taking pre-orders next Wednesday and in-store sales start May 1. It's charging $150 down and $20 per month for two years under its new installment plans.
Verizon Wireless hasn't announced a date.


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Familial Mediterranean fever is a disorder passed down through families (inherited), which involves repeated fevers and inflammation that often affects the lining of the abdomen, chest, or joints.
Familial paroxysmal polyserositis; Periodic peritonitis; Recurrent polyserositis; Benign paroxysmal peritonitis; Periodic disease; Periodic fever; FMF
Familial Mediterranean fever is most often caused by a mutation in the MEFV gene. This gene creates proteins involved in inflammation.
The condition usually affects people of Mediterranean ancestry, especially non-Ashkenazi (Sephardic) Jews, Armenians, and Arabs. People from other ethnic groups may also be affected.
This disease is very rare. Risk factors include a family history of familial Mediterranean fever and Mediterranean ancestry.
Symptoms usually begin between ages 5 and 15. Inflammation in the lining of the abdominal cavity, chest cavity, skin, or joints occurs, along with high fevers that usually peak in 12 to 24 hours. Attacks may vary in severity of symptoms. Patients are usually symptom-free between attacks.
Symptoms may include repeated episodes of:
If genetic testing shows that you have the mutation associated with this condition, and your symptoms match a typical pattern, the diagnosis is nearly certain. Laboratory tests or x-rays can rule out other possible diseases to help make the diagnosis.
Certain blood tests may be higher than normal when done during an attack. Tests may include:
The goal of treatment for familial Mediterranean fever is to control symptoms. Colchicine, a medicine that reduces inflammation, may help during an attack and may prevent further attacks. It can also help prevent a serious complication called systemic amyloidosis.
There is no known cure for familial Mediterranean fever. Most people continue to have attacks, but the number and severity of attacks is different from person to person.
A serious complication is amyloidosis, a condition in which abnormal proteins build up in the organs and joints.
Call your health care provider if you or your child develops symptoms of this condition.
Kastner DL. The systemic autoinflammatory diseases. In: Goldman L, Schafer AI, eds.Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 269.
A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows rigorous standards of quality and accountability. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial policy, editorial process and privacy policy. A.D.A.M. is also a founding member of Hi-Ethics and subscribes to the principles of the Health on the Net Foundation (www.hon.ch)
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- 2013 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.


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As Days of our Lives prepares to celebrate it's 12,000th episode (Friday, January 11, 2013), the show and its fans just got some great news from the NBC network.
Days of our Lives has been renewed through September 2014, it was announced Wednesday by Jennifer Salke, president of NBC Entertainment.
In a statement she said...
"We are thrilled to announce that Days of our Lives is not going anywhere. It is NBC's longest-running drama series by far and is one of the most historic brands in television."
To say the least. It has been on the air 47 years!
"We commend Ken Corday and the entire creative team on continuing to keep the stories and characters fresh, exciting and relevant year after year," she said.
Steve Mosko, President of Sony Pictures Television and a long time supporter of the soap opera then chimed in...
"Days of our Lives has maintained a loyal and dedicated fan base for more than four decades and continues to reach a new generation of viewers. We appreciate NBC's support over the years and, as the show celebrates this significant milestone, we are thrilled that the show will continue to be a part of the NBC family."
The pick up was alluded to this past Sunday at the Television Critics Association's (TCA) winter press tour in Pasadena when head of NBC, Bob Greenblatt, expressed confidence that Days of Our Lives would remain on the schedule.
"I think Days is going to stick around," he said. "I don't know that I'm at liberty to say that officially yet, but it's not going anywhere."
Days of our Lives recently kicked things up a few notches when it brought in some new writers, returned several veteran actors to their much beloved character roles, and embarked on their first same sex love story.
Soapdom could not be happier for Days and all the Days fans. This announcement comes on the heels of Prospect Park confirming that the revitalized All My Children and One Live to Live are indeed a reality and should begin taping within the next few weeks.
This just goes to show you that there are only so many talk and lifestyle shows that the demographic can stomach.
Congrats to Days of our Lives!
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Not sure if I agree with Aldridge and Josh Smith that low.
1 Love
2 Dirk
3 Blake
4 Bosh
6 Aldridge
7 Gasol
8 Amare
9 Josh Smith
10 Duncan.
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Not sure if I agree with Aldridge and Josh Smith that low.
1 Love
2 Dirk
3 Blake
4 Bosh
6 Aldridge
7 Gasol
8 Amare
9 Josh Smith
10 Duncan.
Last edited by vnzla81; 10-15-2012 at 03:26 PM.
Top ten center:
1 Howard
2 Bynum
3 Gasol
4 Chandler
5 Noah
6 Al Jefferson
7 Greg Monroe
8 Cousins
9 Brook Lopez
10Roy Hibbert, Indiana Pacers He doesn't jump like Javale McGee. He doesn't score like Nene, rebound like Marcin Gortat or block shots like Andrew Bogut. Yet Hibbert does everything well enough to get the nod over those more physically gifted centers, a testament to his work ethic and steady improvement. In his fourth NBA season, the 7-foot-2 Hibbert completed his rise from big stiff to All-Star and got a max contract to boot.
Griffin at 3 is ridiculous if you ask me.
"Nobody wants to play against Tyler Hansbrough NO BODY!" ~ Frank Vogel
"And David put his hand in the bag and took out a stone and slung it. And it struck the Philistine on the head and he fell to the ground. Amen. "
I would out DA at 3 and KG at 4. Or switch them. Blake at 5. Bosh or Gasol at 6. Josh Smith at 7 and Amare at 8.
Lopez scores great, but he is not the all-around player that Hibbert is. Nene could beat him out if he was healthy. I would put Cousins ahead of Monroe on pure play.
There are at least 5 guys after Griffin who should be ahead of him.
"I had to take her down like Chris Brown."
-Lance Stephenson
Aldridge underrated like always I could debate him being #1 on the list #6 is a joke. Same with Duncan at #10 his #s will be down because they save him but he should be higher and probably on the C list same with KG they both play more C than PF now and still have a ton of game left.
Cousins at #8 is a joke have him as my #2 but the others Cs are about right 3-10 can go in just about any order IMO not much difference.
Does Kevin Love play any defense? I mean is his defense even as good as Dirk's. Blake doesn't play much defense either
I remember back in the day the power forward position was defense first.
Love played very solid D last year.
Anyway, since this is basically a wishlist and not a real ranking based on what positions these guys actually play.... my top 10s would be:
Top 10 PFs:
1. Love
2. Dirk
3. Aldridge
4. Pau
5. Bosh
6. Griffin
7. Al Horford
8. Duncan
10. Monroe
Top 10 centers:
1. Howard
2. Bynum
3. Marc Gasol
4. Tyson Chandler
5. Duncan
6. Pau
8. Noah
9. Bosh
10. Cousins
Last edited by hackashaq; 10-15-2012 at 04:33 PM.
Lol at Griffin #3 and Noah #5. And for that matter, here's a hearty laugh for Lopez at #9
OK, wait, you are taking Bosh AT CENTER over Hibbert?
A bird in the hand is worth two in the bush.
Or throw in a first-round pick and flip it for a max-level point guard...
I'm taking Bosh over Hibbert at center if that is where I have to play him. Comfortably.
"I had to take her down like Chris Brown."
-Lance Stephenson
Bosh is a much better offensive talent, his D skillset is different but overall defensive quality is similar, he can give much more minutes, and he did an admirable job overall at 5 last year. So, yes.
Man I hate these lists. Players don't play in a vacuum. And yes, I'd say the same thing if Roy were #1.
I'd put Hibbert above Noah and Lopez. Not sure about Monroe, haven't seem him play much.
When will people stop calling Tim Duncan a power forward? It's mind-boggling. He hasn't played primarily as a four since Rasho left.
It's a miracle of miracles that we were a top five team last year with only two players at the bottom of these highly scientific and unbiased reviews... I wonder where our starting five would rank in terms of plus/minus against the other teams...
We have plenty of talent, none of our starters was bad. Also, you've only seen 3 rankings. Granger is ranked #7 among SFs, but vnzla isn't going to make a pro-Granger thread.
You dont remember correctly.
The best power forward in the NBA from 1989-1994 could not play a lick of defense.
It wasn't about being the team everyone loved, it was about beating the teams everyone else loved.
Division Champions 1955, 1956, 1988, 1989, 1990, 2002, 2003, 2005, 2006, 2007, 2008
Conference Champions 1955, 1956, 1988, 2005
NBA Champions 1989, 1990, 2004
Hibbert will be a top 5 center after this year. I wouldn't trade him for anyone in the top ten. I also think West will suprise everyone and be close to a top ten after this year. He was a top ten guy before his injury.
The idea that cousins, monroe, and most laughable Lopez are above Hibbert is truly saddening, since when have these 3 guys been the offensive and defensive focal point for a 50+ win team (adjusted for lock out). I just think to be named top ten at anything you actually have to bring the wins.
You can't get champagne from a garden hose.
I don't want to sound like a homer, but if you watched the 2012 playoffs, David West has to be ranked ahead of Blake Griffin. Whomever made these rankings is obviously a Pacer hater. You cannot convince me that Brook Lopez is a better player than Big Roy
Being unable to close out a game in which you have a comfortable lead in the 4th Q = Pulling a Frank Vogel
Not this again.....
It wasn't about being the team everyone loved, it was about beating the teams everyone else loved.
Division Champions 1955, 1956, 1988, 1989, 1990, 2002, 2003, 2005, 2006, 2007, 2008
Conference Champions 1955, 1956, 1988, 2005
NBA Champions 1989, 1990, 2004
Then you should have stopped after the bold.
And I'm obviously not much of a Griffin fan
"I had to take her down like Chris Brown."
-Lance Stephenson


text:
PowerColor HD7870 2GB GDDR5 Eyefinity 6 Edition
- Part NumberAX7870 2GBD5-6D
- Graphics EngineRADEON HD7870
- Video Memory2GB GDDR5
- Engine Clock1000MHz
- Memory Clock1200MHz x 4 (4.8 Gbps)
- Memory Interface256bit
- DirectX® Support11.1
- Bus StandardPCIE 3.0
- Display ConnectorsMini‐DisplayPort x 6
1000 MHz Engine Clock
2GB GDDR5 Memory
1200MHz Memory Clock (4.8 Gbps GDDR5)
153.6GB/s memory bandwidth (maximum)
2.816 TFLOPS Single Precision compute power
GCN Architecture
o 20 Compute Units (1280 Stream Processors)
o 80 Texture Units
o 128 Z/Stencil ROP Units
o 32 Color ROP Units
o Dual Geometry Engines
o Dual Asynchronous Compute Engines (ACE)
256-bit GDDR5 memory interface
PCI Express 3.0 x16 bus interface
DirectX® 11.1-capable graphics
OpenGL 4.2 support
Partially Resident Textures (PRT)
o Ultra-high resolution texture streaming technology
Image quality enhancement technology
o Up to 24x multi-sample and super-sample anti-aliasing
o Adaptive anti-aliasing
o Morphological Anti-Aliasing (MLAA)
o Enhanced Quality Anti-Aliasing (EQAA)
o DirectX® 9/10/11 Supersample Anti-Aliasing (SSAA)
Requires AMD Catalyst™ 12.2 or laterAMD Eyefinity multi-display technology2
o Up to 6 displays supported
o Independent resolutions, refresh rates, color controls, and video overlays
o Display grouping
Combine multiple displays to behave like a single large display
o Discrete Digital Multi-Point Audio (DDMA)
AMD App Acceleration3
o Supports OpenCL™ 1.2, DirectCompute 11 & Microsoft C++ AMP
o Double Precision Floating Point
o AMD HD Media Accelerator
Unified Video Decoder (UVD)
MVC (Blu-ray 3D)
MPEG-4 Part 2 (DivX/Xvid)
Adobe Flash
DXVA 1.0 & 2.0 support
Video Codec Engine (VCE)
Multi-stream hardware H.264 encoder
Full-fixed mode: 1080p @ 60 FPS encoding
Hybrid mode: Stream Processor-assisted encoding
Enhanced Video Quality features
Advanced post-processing and scaling
o Deblocking
o Denoising
o Automatic deinterlacing
o Mosquito noise reduction
o Edge enhancement
o 3:2 pulldown detection
Advanced video color correction
o Brighter whites processing (Blue Stretch)
o Independent video gamma control
o Flesh tone correction
o Color vibrance control
o Dynamic contrast
o Dynamic video range control
AMD HD3D technology5
o Stereoscopic 3D display/glasses support
o Blu-ray 3D support
o Stereoscopic 3D gaming
o 3rd party Stereoscopic 3D middleware software support
AMD CrossFire™ multi-GPU technology6
o Supports dual-GPU performance scaling
Cutting-edge integrated display support
o DisplayPort 1.2
Max resolution: 4096x2160 per display Multi-Stream Transport
21.6 Gbps bandwidth
High bit-rate audio
Quad HD/4k video support
1080p60 Stereoscopic 3D
o HDMI® (With 4k, 3D, 3GHz, Deep Color and x.v.Color™)
Max resolution: 4096x2160
1600p60 Stereoscopic 3D
Quad HD/4k video support
o Dual-link DVI with HDCP
Max resolution: 2560x1600
o VGA
Max resolution: 2048x1536
Integrated HD audio controller
o Output protected high bit rate 7.1 channel surround sound over HDMI with no additional cables required
o Supports AC-3, AAC, Dolby TrueHD and DTS Master Audio formats
AMD PowerPlay™ power management technology4
o Automatic power management with low power idle states
AMD PowerTune technology4
o Intelligent TDP management technology
o Dynamic clockspeed/performance enhancement for games
AMD ZeroCore Power technology4
o Ultra-low idle power when the connected display is in power saving mode
o Efficient low power mode for desktop work
o Secondary GPUs in an AMD CrossFire™ technology configuration power down when unneeded
AMD Catalyst™ graphics and HD video configuration software
o Software support for Windows 7 and Windows Vista
o AMD Catalyst™ Control Center - AMD Catalyst™ software application and user interface for setup, configuration, and accessing features of AMD Radeon products.
o Unified Graphics display driver - AMD Catalyst™ software enabling other PC programs and devices to use advanced graphics, video, and features of AMD Radeon™ products.
1 The GCN Architecture and its associated features (PCI Express® 3.0, AMD ZeroCore Power technology, DDM Audio, and 28nm production) are exclusive to the AMD Radeon™ HD 7900, HD 7800 and HD 7700 Series.
2 AMD Eyefinity technology works with games that support non-standard aspect ratios, which is required for panning across multiple displays. To enable more than two displays, additional panels with native DisplayPort™ connectors, and/or DisplayPort™ compliant active adapters to convert your monitor's native input to your cards DisplayPort™ or Mini-DisplayPort™ connector(s), are required. Support for six simultaneous displays may require complementary products compatible with DisplayPort 1.2 Multi-Stream Transport. Maximum number of configured displays may vary - check with your component or system manufacturer for specific model capabilities and supported technologies. SLS (―Single Large Surface‖) functionality requires an identical display resolution on all configured displays.
3 AMD App Acceleration is a set of technologies designed to improve video quality and enhance application performance. Full enablement of some features requires support for OpenCL™, DirectCompute or DirectX® Video Acceleration (DXVA). Not all products have all features and full enablement of some capabilities and may require complementary products.
4 AMD PowerPlay™, AMD PowerTune and AMD ZeroCore Power are technologies offered by certain AMD Radeon™ products, which are designed to intelligently manage GPU power consumption in response to certain GPU load conditions. Not all products feature all technologies – check with your component or system manufacturer for specific model capabilities.
5 AMD HD3D is a technology designed to enable stereoscopic 3D support in games, movies and/or photos. Requires 3D stereo drivers, glasses, and display. Not all features may be supported on all components or systems – check with your component or system manufacturer for specific model capabilities and supported technologies. A list of supported stereoscopic 3D hardware is available at http://www.amd.com/HD3D.
6 AMD CrossFire™ technology requires an AMD CrossFire Ready motherboard, an AMD CrossFire™ Bridge Interconnect (for each additional graphics card) and may require a specialized power supply.
7 Utilization of PCI Express 3.0 bandwidth requires a mainboard equipped with a PCI Express 3.0 PHY. Not all mainboards feature this technology – check with your component or system manufacturer for specific model capabilities.
|Graphics Engine
|Video Memory
|Engine Clock
|Memory Clock
|1200MHz x 4 (4.8 Gbps)
|Memory Interface
|DirectX® Support
|Bus Standard
|Standard Display Connecors
|Mini‐DisplayPort x 6
|Feature Support
|CrossFireX™ Technology
|ATI Stream Technology
|ATI Eyefinity Technology
|ATI Hypermemory Technology
|Display Support
|VGA Output
|DVI Output
|On Board (Mini DisplayPort) x6
|TV Output
|HDTV Output
|HDCP Support
|Maximum Resolution
|Power Specs + Board Dimensions
|Board Dimensions
|Minimum System Power requirement (W)
|Extension Power Connector
|Two 6-Pin PCI Express Power Connectors
CrossFire Cable (Optional)
Mini DP to Single Link DVI Cable x 2
Mini DP to DP Cable x 4
Software Bundled
Driver (PCIE,PCI)
Powerup Tuner
|Product Name
|HD7800 series
|HD7800 series (HD7850/HD7870)
|Win8.1/Win8/Win7 32bit
|Download 1(Taiwan) Download 2(Worldwide)
|HD7800 series
|HD7800 series (HD7850/HD7870)
|Win8.1/Win8/Win7 64bit
|Download 1(Taiwan) Download 2(Worldwide)
|HD7800 series
|HD7800 series (HD7850/HD7870)
|WinXP 32bit
|Download 1(Taiwan) Download 2(Worldwide)
Work smarter and play harder on up to 6 displays
Taipei, Taiwan –April 25th, 2012 -- TUL Corporation, a leading manufacturer of AMD graphics cards, today releases the only HD7870 graphics solution which can support up to 6 displays simultaneously: the PowerColor HD7870 Eyefinity 6. The latest edition optimizes multi-display Eyefinity technology, enabling up to six monitors to be operated from one card through its six mini display port onboard design. This unique feature allows gamers to enhance productivity to get more things done at once, also delivering the most vivid HD gaming experience with wider view.
Flexible display configurations
The HD7870 Eyefinity 6 clocks in at 1000MHz core speed and 1200MHz of memory speed; with 2GB GDDR5 onboard memory, the latest edition allows more bandwidth for demanding DirectX® 11.1 gaming title, delivering the intense gaming performance and unrivaled image quality with lifelike 3D visual effects.
The HD7870 Eyefinity 6 takes advantage of AMD PowerTune technology, enabling higher clockspeeds while needed through unused TDP headroom; by utilized AMD ZeroCore Power technology, allowing GPU to consume virtually no power in idle mode, delivering the best power efficiency. Also, with the support of AMD APP Acceleration, it creates a "co-processing" environment of GPU and CPU, simply speeds up the everyday applications.
PowerColor HD7870 Eyefinity 6
Core Speed
Memory Speed
1200MHz (4.8Gbps)
Memory Bandwidth
6 x mini DisplayPort
About TUL Corporation
TUL is a leading supplier of AMD graphics cards under the PowerColor brand. We offer award-winning products based on our technology leading components, quality design and superb engineering. TUL employs more than 150 talents worldwide, with offices in China, Europe, Russia and USA to support over 300 channel partners and distributors in 50 plus countries. For further information, visit: http://www.tul.com.tw/global/
For more product information, visit: www.powercolor.com.
Or contact: firstname.lastname@example.com


text:
About Financial Planning
Personal financial planning is the process of meeting your life goals through the proper management of your finances. Life goals can include buying a home, saving for your child's education or planning for retirement.
The personal financial planning process consists of six steps that help you take a holistic approach to assessing where you are financially. Using these steps, you can work out where you are now, what you may need in the future and what you must do to reach your goals.
The process involves gathering relevant financial information, setting life goals, examining your current financial status and coming up with a strategy or plan for how you can meet your goals given your current situation and future plans.
Personal financial planning provides direction and meaning to your financial decisions. It allows you to understand how each financial decision you make affects other areas of your finances. For example, buying a particular investment product might help you pay off your mortgage faster or it might delay your retirement significantly. By viewing each financial decision as part of a whole, you can consider its short and long-term effects on your life goals. You can also adapt more easily to life changes and feel more secure that your goals are on track.
© 2006, Financial Planning Standards Board Ltd. All rights reserved. Through a licensing agreement, material in this section is based wholly or in part on copyrighted materials owned by Certified Financial Planner Board of Standards Inc. See our copyright notice for more.


text:
Updated with stock price. CAMBRIDGE, Mass. ( TheStreet) -- Final overall survival results from the phase III study of Aveo Pharmaceuticals' ( AVEO) kidney cancer drug tivozanib were released Tuesday night, and as expected, tivozanib-treated patients were at a greater risk of death than those treated with Onyx Pharmaceuticals' ( ONXX) Nexavar. At the median, the difference in survival was just two weeks. Tivozanib-treated patients reported a median overall survival of 28.8 months compared to 29.3 months for Nexavar patients. However, when overall survival in the study was analyzed over two years, the relative risk of death was 25% higher in the tivozanib arm relative to the Nexavar arm.
Hazard ratio = 1.245. While survival trended against tivozanib, the greater risk of death was not statistically significant. Aveo has struggled for months to assuage investor concerns about the confounding results from the tivozanib study in advanced kidney cancer patients. Tivozanib met the primary endpoint of the study by delaying tumor regrowth by almost three months more than Nexavar (11.9 months vs. 9.1 months.) However, this significant improvement in progression-free survival favoring tivozanib did not help patients live longer. Last August, shares of Aveo fell from $14 to $8 when the company first disclosed FDA's concerns about the confounding survival analysis from the tivozanib trial. Aveo shares closed Tuesday at $7.89 but were down 11% to $7.04 in early Wednesday trading. Aveo believes overall survival of tivozanib was snake bit by a study design that allowed patients treated initially with Nexavar to receive effective, subsequent therapy, including tivozanib. Of the 257 patients who started the study on Nexavar, 74% "crossed over" to receive treatment with other kidney cancer drugs, including tivozanib and other so-called VEGF therapies like Pfizer's ( PFE) Sutent or GlaxoSmithKline's ( GSK) Votrient. By comparison, 36% of the patients treated initially with tivozanib went on to receive additional kidney cancer drugs, including 10% who received subsequent VEGF therapies. In certain smaller subsets of patients, overall survival trended in favor of tivozanib over Nexavar, the opposite of what occurred in the study as a whole. Some of these alternate survival analyses were pre-defined in the study's statistical analysis plan, while others were not, a company spokesman said.
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text:
The Day Ahead: Hot Mess or Hot Air?
At some point Monday, I got the eerie sense that the Grim Reaper was getting ready to pounce on my generally bullish stance on the market -- a feeling I haven't had since the "fiscal cliff" permeated the markets in December. After some investigation, here is what I was able to decipher from this sentiment shift.
Hot Mess or Hot Noise?...506 more words left in this article. To read them, just click below and try Real Money FREE for 14 days.
There's no substitute for a trading floor to get great ideas, so Jim Cramer created a better one at Real Money and blogs there exclusively. We then added legendary hedge fund manager, Doug Kass, with his exclusive Daily Diary and best investing ideas. Staffed with more than 4 dozen investing pros, money managers, journalists and analysts, Real Money Pro gives you a flood of opinions, analysis and actionable trading advice found nowhere else, and allows you to interact directly with each expert.
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