text:
Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
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- How to Read a Study Record
|Down Syndrome Subclinical Hypothyroidism
|Drug: Levothyroxine
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Care Provider)
Primary Purpose: Treatment
|Official Title:
|Levothyroxine Treatment and Cardiometabolic Outcomes in Adolescents With Down Syndrome
- Change in non-HDL cholesterol from baseline at 6, 12 and 18 months. [ Time Frame: baseline, 6 months, 12 months & 18 months ]Lipid panel will be measured via fasting blood draw.
- Change in quality of life from baseline at 6, 12 and 18 months. [ Time Frame: baseline, 6 months, 12 months, & 18 months ]Questionnaires will be done with participants and parents on the day of each study visit to determine body image and quality of life.
|Estimated Enrollment:
|Study Start Date:
|January 2013
|Estimated Study Completion Date:
|October 2017
|Estimated Primary Completion Date:
|October 2017 (Final data collection date for primary outcome measure)
|Assigned Interventions
Placebo Comparator: Treatment Phase: Months 6-18
Subject who are found to have SCH at the 6-month visit will be randomized to receive either levothyroxine or placebo during months 6-12. Levothyroxine dose will be between 0.5 - 1 mcg/kg/day. There will be 1 blood draw visit at month 7.5 (6 weeks after randomization) and 1 study visit at month 12 that will provide the opportunity for dose adjustments if needed.
From months 12-18, all subjects will receive levothyroxine. Levothyroxine dose will be between 0.5 - 1 mcg/kg/day. There will be one blood draw visit at month 13.5 that will provide the opportunity for dose adjustments if needed.
Drug: Levothyroxine
Other Names:
No Intervention: Observation Phase: Months 0-6
Subjects will be observed for the first 6 months of the study to ensure that the subclinical hypothyroidism is persistent. Subjects who do not have SCH at 6 months will not proceed to the treatment phase.
Subjects that have TSH >10 mIU/L during the 6 month Observational Phase will not be considered subclinical and will not qualify to continue the study. They will be referred to an endocrinologist for treatment.
Detailed Description:
The American Academy of Pediatrics (AAP) recommends yearly screening of thyroid studies in DS. Clinical experience suggests that TSH concentrations in the subclinical hypothyroid range (5-10 milli international units(mIU/L)) are not uncommon in DS, but the benefits and risks of treating SCH in the DS population are not known. In adults, SCH has been associated with increased cardiometabolic risk (CMR) and individuals with DS may be at increased cardiometabolic risk as well.
Data in children with SCH are limited. Despite the recommendations to screen for thyroid dysfunction, evidence to guide management of elevated TSH in children with DS is equally sparse. In non-DS children, TSH>4.65 mIU/L was associated with lower HDL. One year of levothyroxine treatment in short children with subclinical hypothyroidism and short stature improved growth velocity. Left ventricular (LV) function and LV mass (by echocardiography) was not different in 16 children with DS and subclinical hypothyroidism (TSH>6.5 mIU/L; mean TSH = 7.8 mIU/L) vs. 25 children with DS and normal TSH. However, these findings may be limited by the small sample size. An intervention study of 7 subjects age 2-42 years with DS and hypothyroidism, defined as low T4 and normal or elevated TSH (0.2-18.9 mIU/L) on 8 weeks of levothyroxine treatment did not improve developmental or functional outcomes. Anthropometrics and CMR factors were not examined. In contrast, increased TSH in the absence of overt congenital hypothyroidism is common in neonates with DS and prompted a randomized controlled trial (RCT) in 181 neonates with DS. TSH-directed levothyroxine treatment was associated with better growth, weight gain, and motor development after 24 months compared to placebo. These findings highlight that the "asymptomatic" component of subclinical hypothyroidism may have medically-relevant effects. This study will provide potentially clinically relevant preliminary evidence for the treatment of subclinical hypothyroidism in DS.
|Ages Eligible for Study:
|8 Years to 20 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Males and females, ages 8 - 20 years
- Diagnosis of Down syndrome
- Subclinical hypothyroidism: TSH level between 5 - 10 mIU/L, normal T4
- Parental/guardian permission (informed consent) and if appropriate, child assent
- Females who are at least 11 years of age or who are menarchal must have a negative urine/serum pregnancy test
- Committed to adherence to levothyroxine treatment and study completion
Exclusion Criteria:
- Pregnancy
- Type 1/Type 2 diabetes
- Chronic medical conditions or medication use that can affect growth, nutrition, blood glucose, insulin secretion, or thyroid function (such as lithium or certain seizure medications)
- Current use of levothyroxine or anti-thyroid hormone
- Cyanotic congenital heart disease, or pulmonary hypertension (as described by last echo report in subjects with CHD), or congenital heart disease considered medically unstable by the study cardiologists
Please refer to this study by its ClinicalTrials.gov identifier: NCT01832753
|United States, District of Columbia
|Children's National Medical Center
|Washington, D.C., District of Columbia, United States, 20010
|United States, Pennsylvania
|The Children's Hospital of Philadelphia
|Philadelphia, Pennsylvania, United States, 19104
|Principal Investigator:
|Andrea Kelly, MD, MSCE
|Children's Hospital of Philadelphia
|Responsible Party:
|Children's Hospital of Philadelphia
|ClinicalTrials.gov Identifier:
|NCT01832753 History of Changes
|Other Study ID Numbers:
1R01HD071981-01A1 ( U.S. NIH Grant/Contract )
|Study First Received:
|April 9, 2013
|Last Updated:
|June 2, 2017
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Keywords provided by Children's Hospital of Philadelphia:
Down syndrome
subclinical hypothyroidism
Additional relevant MeSH terms:
Down Syndrome
Pathologic Processes
Intellectual Disability
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn
Thyroid Diseases
Endocrine System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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A MAN has died after suffering serious injuries when he was hit by a HGV on a North Yorkshire road last night.
The incident happened at 7.45pm on the A64 near Sherburn, between Malton and Scarborough, and involved the man and a white and blue DAF lorry.
A spokeswoman for North Yorkshire Police said the 25-year-old local man had been found in the middle of the road, and taken to Hull Royal Infirmary with serious injuries, but he died this morning.
The man's family have been informed, but his identity has not yet been released.
The A64 was closed in both directions to allow officers to carry out an investigation into the collision, and was reopened just after midnight.
Officers have appealed to anyone who witnessed the collision or saw anyone walking along the side of the carriageway prior to the incident, to get in touch with information.
Anyone with information should phone North Yorkshire Police on 101 or email email@example.com
The police spokesman said the driver of the HGV did stop at the scene but had not been arrested.

subset: commoncrawl


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Gerry Jesk, right, fills a box with cookies at the First United Methodist Church's Bazaar and Cookie Walk Saturday in Chiefland. The event aimed at raising money for church activities.
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text:
'A source says DuRoss, who owns the Rochester Rhinos soccer team and the Providence Bruins of the AHL, is still in the process of putting his ownership group together, and met with Bettman to see if he'd be encouraged to continue. DuRoss apparently was encouraged to pursue ownership of the Sabres, even though it appears the group headed by Buffalo Destroyers owner Mark Hamister is in far stronger position to complete a deal.'
You are here: Home / SabresBeat / Two's company in quest for Sabres ownership


text: This news item expired on 3/31/2013, so the information below could be outdated or incorrect. Register of Deeds Has New Recording Hours The Register of Deeds requested that the Board of Commissioners change our recording hours to better serve the citizens of Buncombe County. Effective January 15, 2013, we will now be accepting documents for recording beginning at 8 a.m. until 5 p.m. each work day. Please see the approved and adopted resolution attached below. Table: News Item Documents File NameSizeTypeDate & Time Added Resolution #13-01-07 86 KB 01/25/2013 9:27 AM


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What's your toddler's personality type?
Knowing this could impact your parenting style more than you realise. more
For your chance to WIN a Banana Boat beach bag prize pack, simply share your best Summer Fun photos and a great caption! ENTER HERE!
1. Instructions on how to enter form part of these Conditions of Entry. Participation in this Promotion is deemed acceptance of these Conditions of Entry.
2. The competitions are open to all residents of Australia and New Zealand that are over the age of 18 years and are members of Kidspot Social, except employees of the Promoter and members of their immediate families and agencies associated with this promotion.
3. Promotion commences on Tuesday, 3 January, 2012 (AEST) and closes at 11.59pm on Monday, 23 January, 2012 (AEST) ["Promotional Period"].
4. To enter into the Kidspot Banana Boat Summer Fun With Mum Photo Competition, members must login or create a Kidspot Social account. CLICK HERE to access our quick sign-up page.
5. To enter the Summer Fun With Mum Photo Competition, entrants must post a photo of their kids or family enjoying the Australian Summer into the Summer Fun With Mum group photo album, including a caption of 50 words or less.
6. Members may enter up to three (3) times, subject to the following:
a) each entry must be substantially unique; and
b) each entry must be submitted separately and in accordance with entry requirements, and
c) only one Kidspot Social member per household may enter.
7. Incomplete, illegible and inappropriate entries will be deemed invalid and will not be included in the judging.
8. If the entry is deemed inappropriate or offensive, it will be removed by Kidspot administrators at their discretion.
9. The winners' entry photo, caption, Kidspot Social profile photo and details may be posted to the Kidspot Facebook page as well as across various Kidspot communication channels.
10. At the end of the promotion period, a panel of judges appointed by the Promoters will choose ONE Major Winner and THREE Runner-Up Winners from the pool of all entries entered into competition topic over the duration of the competition. Judging will take place at Kidspot, Level 5, 14 Queens Road, Melbourne Victoria 3004.
11. The winners will be announced in the competition topic within a week of the competition ending date.
12. Each entry will be individually judged based on photo and caption originality, creative merit and alignment with the 'Summer Fun With Mum' theme.
13. The Major Prize winner of the Kidspot Banana Boat Summer Fun With Mum Photo Competition will receive the following prize, valued at $180 RRP:
- Beach bag
- Beach shelter
- Banana Boat Ultra
- Banana Boat Sensitive
- Banana Boat Kids Mineral Protect
- Banana Boat UltraMist Sport
- Banana Boat Dry Touch Sport
- Banana Boat Baby Spray
- Banana Boat Aloe Vera Spray
- Banana Boat Aloe Vera Lip Balm
- Banana Boat Face Oil Free
Please allow 2-4 weeks for prize delivery.
14. The 3 x Runner-Up Prize winners of the Kidspot Banana Boat Summer Fun With Mum Photo Competition will receive the following prize, valued at $60 RRP:
- Beach bag
- Banana Boat Mineral Protect Sensitive 200g
- Banana Boat Sport 200g
- Banana Boat EveryDay 400g
Please allow 2-4 weeks for prize delivery.
15. All Kidspot Social competition winners must:
a) Agree to have their entry featured on the Kidspot Social homepage
b) Be agreeable to the usage of their profile photo and details within Kidspot onsite creative, editorial features and email communication
c) Provide all necessary contact details to allow for prize delivery and communication with Kidspot in relation to the Kidspot Banana Boat Summer Fun With Mum Photo Competition.
d) Be agreeable to their contact details being provided to Kidspot (Promoter) and Banana Boat (Prize provider) for the purposes of prize fulfilment.
16. The judges' decision in relation to all aspects of this promotion is final and binding on all who enter and no correspondence will be entered into.
17. The Kidspot Banana Boat Summer Fun With Mum Photo Competition is a game of skill and chance plays no part in determining the winners.
18. The Entrant's entry must be original and must not infringe on any third party's intellectual property rights. The Promoter reserves the right to seek a declaration from any entrant that their entry complies with this clause.
19. The Promoter reserves the right, at any time, to verify the validity of entries and entrants (including an entrant's identity, age and place of residence) and to disqualify any entrant who submits an entry that is not in accordance with these Conditions of Entry or who tampers with the entry process. Failure by the Promoter to enforce any of its rights at any stage does not constitute a waiver of those rights.
20. If for any reason this promotion is not capable of running as planned, including infection by computer virus, bugs, tampering, unauthorised intervention, fraud, technical failures or any other causes beyond the control of the Promoter which corrupt or affect the administration, security, fairness, integrity or proper conduct of this competition, the Promoter reserves the right in its sole discretion to disqualify any individual who tampers with the entry process, and to cancel, terminate, modify or suspend the competition.
21. In the event that for any reason whatsoever a prize winner does not take an element of the prize at the time stipulated by the Promoter, then that element of the prize will be forfeited by the prize winner. If the prize is forfeited within twenty four business hours of the notification taking place, a re-judging will occur immediately.
22. Any costs associated with accessing the Kidspot website are the responsibility of the person seeking access and are dependent on the internet service provider used.
23. All entries are deemed to be received at the time of receipt by the Promoter, not time of transmission by the entrant. The Promoter accepts no responsibility for late, lost or misdirected entries.
24. All entries submitted become the property of the Promoter.
25. Except for any liability that cannot be excluded by law, the Promoter (and their respective officers, employees and agents) exclude all liability (including negligence), for any personal injury; or any loss or damage (including loss of opportunity); whether direct, indirect, special or consequential, arising in any way out of the Promotion, including, but not limited to, where arising out of the following: (a) any technical difficulties or equipment malfunction (whether or not under the Promoter's control); (b) any theft, unauthorised access or third party interference; (c) any entry or prize claim that is late, lost, altered, damaged or misdirected (whether or not after their receipt by the Promoter) due to any reason beyond the reasonable control of the Promoter; (d) any variation in prize value to that stated in these Conditions of Entry; (f) any tax liability incurred by a winner or entrant; (g) the prize and/ or (h) participation in the promotion.
26. Kidspot Australia values its visitors and clients and respects their privacy. We collect client information in an effort to improve your advertising experience and to communicate with you about our products, services, and promotions.
If you have any questions about our privacy policy, you can always contact Kidspot Australia customer service in any of three ways: send us an e-mail, call us at 1300 724 575 or write to us and fax to 61 3 8640 0647.
27. The Promoters are Kidspot Pty Ltd, Level 5, 14 Queens Road, Melbourne VIC 3004


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Lowrie held out of starting lineup with contusion
ARLINGTON -- Infielder Jed Lowrie's bruised right foot was sore enough to keep him out of the starting lineup in Texas on Wednesday, but not enough for his manager to rule him out of entering the game at some point.
"He won't be pinch-running today, let's put it that way," Oakland's Bob Melvin said. "But as I'm sitting here right now, I'd hate to say there's no chance of using him in an emergency. Certainly we'll try to stay away from him, though."
There was no such emergency in Oakland's 3-1 loss, and even if there was, Lowrie likely couldn't have offered much help, since his foot was so bruised that he couldn't fit it in a cleat.
Lowrie was serving as designated hitter on Tuesday night when he took a Yu Darvish pitch off his foot in the fifth inning. He was taken out of the game for a pinch-hitter in the seventh to go for X-rays that proved negative.
Melvin is hopeful that, with Thursday's off-day, Lowrie will be able to rest his foot enough to be ready to return to the starting lineup Friday in Houston.
"I just want to play," he said. "I want to be out there as quickly as I can, but I can't really give a timetable because I don't know when the swelling is going to go away."
Lowrie entered the day 4-for-8 on the road trip, with his season average on the road up to .337.
Jane Lee is a reporter for MLB.com. Read her blog, Major Lee-ague, and follow her on Twitter @JaneMLB. This story was not subject to the approval of Major League Baseball or its clubs.


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Topic: Does 5-FU work just as well as Xeloda?
I was just wondering if anyone knew if 5-Fu worked as well as Xeloda. Lauren's oncologist seems to favor Xeloda and I don't understand why. Xeloda gives her a bunch of problems and 5-Fu was a breeze. What do you think? She is also on Gemzar at this time. She was on Oxaliplation with Xeloda, but had the allergic reaction to Oxaliplatin and has since been put back on Gemzar. Thanks in advance for your input.
My comments, suggestions, and opinions are based on my experience as a caretaker for my daughter, Lauren and from reading anything I can get my hands on about Cholangiocarcinoma. Please consult a physician for professional guidance.


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The words "run like Rackspace" are something we hear from customers and prospects all the time. Everyone from enterprise CIOs to ISV development leads want to build private clouds that look, feel and operate like our open public cloud. They want the same software, the same configuration and the same operations that power our public cloud, but they want it all to themselves, most often in their own data centers.
Two years ago, when we first started in the private cloud world supporting clouds in customers' data centers, we operated as a consultancy.
We took raw OpenStack code and used our expertise in running a large public cloud to build custom private clouds for customers.
Every customer had a different idea of what their private cloud should look like, and we'd end up helping them build what I like to call "Crazy Cloud™" (trademark inflection is my own). You can define Crazy Cloud as an unsupportable mixed bag of bits that fits well in the existing enterprise model. Basically, we were building one offs that were difficult to support but were exactly what the customers were asking us for at the time.
What we learned very quickly from customers was that they wanted to work with us more once we expressed our strong opinions on what they should be building and running on their premise rather than letting them tell us what to build. This was the opposite of our initial assumptions that people wanted our expertise to build them a custom cloud – the reality is that they just wanted the Rackspace Cloud in their own data center.
In addition to being prescriptive about what a "good" private cloud looks like from a software and infrastructure perspective, we also believe strongly in the operations model of cloud. Last month I blogged about how your cloud needs a pit crew and how software and hardware makes up 25 percent of your cloud and good operations makes up the other 75 percent.
When customers say they want to "run like Rackspace," what they really mean is that they want the experience of just being able to use their cloud. They want our bits, for sure – and those are free and open source with our OpenStack-powered Rackspace Private Cloud Software. But in addition to the software, customers want our expertise in configuring, operating, upgrading and the overall care and feeding of their private cloud. This is what we're really good at. We do it for our public cloud, and we're doing it now for a growing number of enterprises.
There were some Twitter and blog discussion last week about how the only thing we would operate is our own OpenStack-powered Rackspace Private Cloud Software. The biggest source of discussion that I saw was a question that went like this: "is Rackspace Private Cloud a fork of OpenStack and that's why they won't/can't provide operations for other versions?"
Short answer: No, we deliver community OpenStack with a proven Rackspace Cloud configuration, tools and deployment model – not a fork. We work hard to be completely open and transparent in the community about what we're doing. Everything we do for Rackspace Private Cloud is on github, and Rackspace Private Cloud leverages the fully open source community packages for the OpenStack components (Nova, Swift, Glance, Horizon, Keystone, Cinder, Quantum, etc.) directly from the Ubuntu package repository. These are the same exact packages that the OpenStack developers themselves use for their development and test environments. Rackspace Private Cloud Software then deploys and configures those packages "the Rackspace way" using more open source tools and cookbooks that we've built (all available at http://github.com/rcbops/).
The reason we aren't offering private cloud operations for other private cloud software is simply market demand – customers are asking to run like Rackspace, which is hard to do on someone else's interpretation of what a cloud should look like (see: Crazy Cloud, above).
Don't build Crazy Cloud! Our Rackspace Private Cloud Software is free and open source, we have published reference architectures for private cloud that are open and freely available on our website and you don't have to pay us for anything or worry you are getting a fork of OpenStack when you choose to do things the Rackspace way.
Remember the cloud equation: software and hardware are 25 percent, operations is 75 percent. If you truly want to run like Rackspace, there's only one way to do that – let us use our experience in operating large OpenStack-powered open clouds to operate your private cloud so you can focus on the real value of cloud: using it.
Questions or comments about this blog post? Let me know below or on Twitter: @scottsanchez


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LOS ANGELES - A high school teacher who had sex with two of her male students was sentenced today to five years probation and barred from teaching.
Gabriela Cortez, 43 -- a Spanish teacher at Roosevelt High School in Boyle Heights -- pleaded guilty Nov. 19 to six felony counts of unlawful sexual intercourse.
Los Angeles Superior Court Judge Edmund W. Clarke Jr. told Cortez that parents have an expectation that "when a child goes off to school he will be treated as if they were there watching" and that Cortez breached that trust.
But the judge said he was persuaded by Cortez's attorney, Edward Robinson, that probation would be "the just sentence."
The conditions of probation bar Cortez from working in any teaching, coaching or mentoring position and from being in the presence of minors -- other than her own daughter -- without other adults present. She is also required to undergo counseling, which the judge said had already begun.
The crimes occurred between September 2009 and November 2010, primarily in Cortez's Montebello home, when the boys -- now adults -- were 16 and 17, according to Deputy District Attorney Hyunah Suh.
Cortez was arrested Feb. 22 by Montebello police and released later that day after posting $140,000 bail.
Montebello police Lt. Luis Lopez said the investigation began Feb. 15, after one of the victims came forward to report being molested by a teacher, saying he wanted to get things "off his chest."
The investigation triggered by that victim led to the second victim, who "provided information regarding a sexual relationship involving him and the suspect," the lieutenant said.
Cortez could have served a maximum sentence of six years and four months behind bars. A probation report requested by the judge also recommended granting probation rather than jail time, according to Suh.


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2013 Inaugural Address of Indiana Attorney General Greg Zoeller
Four years ago I took this same oath to serve the state of Indiana "to the best of my skill and ability." There have been challenges - such as serving the victims of our state fair tragedy - that tested the limits of everyone's skill and ability.
But I hope that I have lived up to the honor given me to represent the people of this great state and all those who work in service to the public.
I've spent the last few weeks thanking those who helped me have the opportunity to continue to serve as your Attorney General.
- My wife Kerrie and our children, Gretchen, Katherine and Michael. They help me appreciate my many blessings.
- The men and women who serve in the Office of the Attorney General. I am proud to be the office holder but I appreciate that they are the ones who get the job done.
- The people of Indiana who place their trust in me as their attorney general.
Indiana has been blessed with remarkable leaders in our three branches of government - Governor Daniels, Chief Justice Shepard, Speaker Bosma, Senator Long and legislators from both parties.
I consider myself fortunate to have been the attorney general during these leaders' tenure.
Bold, visionary leadership presents challenges for the lawyers who are tasked with representing our state. But my role would not have been as fulfilling without these challenges.
And during these next four years with our new governor – (my new client) – Mike Pence, Indiana faces a unique challenge - one that many would envy.
The challenge of making the most of the opportunity we have been given.
Expectations are high and the public has every right to ask that we meet these expectations.
Good is simply not good enough.
And so I welcome the chance to partner with, and serve, Governor Pence as he "takes Indiana from good to great!"
For my own part I too accept Hoosier's higher expectations.
My office will endeavor to serve the three, coequal branches of government and build bridges between their separate authorities by convening a coalition of our clients in common purpose.
Many of our challenges require each of the separate branches to cooperate and support each other's efforts to address complex issues.
The Office of the Attorney General will strive to become a "force multiplier" within government.
And I also plan to work in partnership with attorneys general across the nation – in both parties who each represent the sovereign authority of our sister states.
Representing the bold leadership of a state requires more than defending it when challenged in court.
Under our constitutional system of federalism we must strengthen and reassert our role as part of the necessary checks and balances on our federal government.
In my view, we must do more to reestablish our state sovereignty and push back overzealous encroachment by the federal government.
So today, as I once again take an oath to serve "to the best of my skill and ability," and working in common purpose with our elected leaders and our sister states … collectively we must rise to the occasion to meet the high expectations of Hoosiers to serve the state we are proud to call home.
And so each morning, when I begin my day reciting the "lawyer's prayer" of Saint Thomas More, I will be grateful for this privilege to be lawyer and servant for Indiana during these days of great opportunity.
And I ask God to help our efforts and bless the people of Indiana.


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Snowmobiler Caleb Moore dies after Winter X Games crash
He passed away on Thursday (31Jan13), exactly one week after he flipped over the handlebars of his snowmobile while attempting to do a back-flip during the freestyle finals in Aspen, Colorado on 24 January (13).
Moore was hospitalised with a concussion, and eventually underwent emergency heart surgery, but he never recovered from the severe brain and heart trauma. He was 25.
A statement from the family to CNN reads, "He will be truly missed and never forgotten. The family wishes to express their deep gratitude for all the prayers and support they have received from all the fans, friends and family around the world that Caleb has inspired."
Meanwhile, bosses at TV sports network ESPN, which hosts the sporting event, are conducting their own investigation to determine whether any safety measures need to be changed to prevent another sickening accident in the future.
A statement from the company reads, "We are deeply saddened by Caleb Moore's passing and our thoughts and prayers go out to his parents, Wade and Michelle, his brother, Colten, and the entire Moore family. He will be remembered for his natural passion for life and his deep love for his family and friends, and he will always be an inspiration to everyone he touched in the action sports community."


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MIAMI, Fla. - A panel of federal judges is hearing Florida's appeal of a Miami judge's ruling that struck down a state law restricting what doctors can discuss about guns with their patients.
The 11th U.S. Circuit Court of Appeals hearing is Thursday in the so-called "Docs vs. Glocks" case. The law passed in 2011 was declared unconstitutional by U.S. District Judge Marcia Cooke, who agreed with doctors and gun control advocates that it violated the free speech rights of Florida physicians.
The state's appeal calls that ruling an error, arguing the law does allow such conversations for medical and safety-related reasons. But lawyers for the doctors say the law has a chilling effect because of possible fines or loss of licenses for violations.
The appeals court will likely rule in coming months.
Copyright 2013 by ClickOrlando.com. The Associated Press contributed to this report. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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I procured this vidcam for work a couple of years ago, looking for something that was not only compatible with our systems but also had plenty of the features that people using it would need. Our previous vidcams had been much lower as they had been bought a good few years before that, and while they were decent quality at the time, it indicates just how fast the technology moves on that they are now considered only as emergency backup at work.
The Panasonic SDR-S50 series of video cameras pride themselves on their quality no matter the scenario you're filming in. What caught my attention first of all with this was not the ease of use, but the powerful zoom. Having researched carefully and finally bought the product, this was the first thing I looked for in trying it out. Before doing this though, it's important to get the full charge onto the battery, which is detachable and attached to the rear and exterior of the device but is specific to the device. We've moved away from buying devices which use AA and AAA batteries as buying reliable rechargeable ones when they're in constant use and regularly need to be charged up leads to all sorts of issues with testing and reliability, so devices with their own specific battery design are preferred.
Once fully charged, which only takes a couple of hours, it's time to turn it on. Opening the side viewfinder, it's obvious straight away that this swivels vertically to offer 360 degree visibility when filming at awkward height angles. The revealed interior contains a few buttons, including the power and delete options, as well as the slot for the SD card. Pressing the power button, the device turns on very easily. It's a tiny button and you have to make sure you've clicked it. I know many people use nails to press buttons but unless you use your actual finger you may think the button isn't working. I wouldn't say this is a fault or a criticism, merely an observation.
Open the lens cap! There's a very simple slide button at the front of the device that slides the lens cap down, an interior one rather than a removable clickable cover, but make sure you remove it! The amount of times I've had to remind people that you'll only get useful audio if you film the inside of the lens cover. If you're worried about reminding yourself, make sure you can see what you're filming through the viewfinder before pressing the record button.
It holds like a regular horizontal video camera, a strap provided on the right to slide your fingers through when getting ready to film. This is adjustable, with velcro. Very easy to do with your left hand to get the proper tightening without the need to remove your hand. Once your hand is in place, you should find the relevant controls where you need them. The first thing I did was check out the zoom. There's a toggle button on the top which your index should sit comfortably by when you've slotted your hand through the strap, and as you move your finger from side to side, you zoom in and out. Moving it by a small amount zooms slowly, and moving it as far as it will go zooms substantially quicker. And I wasn't disappointed. I work where there are clear views across a valley a good mile or two away, and I used this as a good test to see how far I could zoom in and still see. I was able to focus on a building at a substantial distance away, and clearly see features such as drainpipes, stains on walls, fencing, even leaves on trees. It's the x78 optical zoom that did it, and it's one of its biggest positives. One particularly popular use has been in filming sports; where filming from one sideline at a rugby match for example used to be a pain to get the action all the way on the other side, with this you wouldn't miss a thing. For coaching, it's really good.
There's no waterproof feature on this though, so for outdoor use in wet weather conditions, you'd still need the protection of an umbrella or something like that. I wouldn't get this wet - it looks as if there are too many easy opportunities for water to cause untold damage. The record button is conveniently located though, so whereas your index finger sits perfectly poised for zooming, your thumb can't help but sit right next to the record button, which is adjacent to the slim battery pack on the rear. Depressing it makes it obvious when it's recording, and a red light appears on the viewfinder and the time starts ticking. You can zoom during recording too.
Another in-filming feature is the photo button. Pressing this takes a photo without making a sound, so that you can have video and photo footage of the same thing. I get annoyed by some video cameras which make an audible noise when you click buttons, take a photo or do any other function during filming - it detracts from the quality of the audio and can be very annoying. There's none of that with this video camera.
Film quality is very good, crisp and clear. The zooming allows for dynamism in filming, and reviewers who are disappointed at the quality of some of the videos may not have made full use of some of the extra features. Using the OIS (optimum image stabilisation, I think) feature allows for filming things that are moving but keeping them without blurring. At zoom level, you can imagine that a lot of the moving elements are moving at more of a pace where the camera is concerned, and if you're not on a tripod or have nerves of steel, then there's the motion of your hand to take into account. OiS with filming and using the iA focus option with photos make sure that the focus is spot on and no blurring happens.
Just be careful what filming options you have selected though - I've seen plenty of disappointing filming where outdoor settings are used indoor and there's a slight streak around some objects as if looking through hazy eyes or some film director has applied a visual dynamic setting to make you on edge. Reading the instructions carefully and making the wide range of settings are properly used is the key to getting this to work. I'm not saying it's completely perfect, as there are newer models that are now even better, but this will give you crisp and clear videos and photos as long as you have the correct settings in place.
An 8GB SD card should give you a couple of hours of footage, and while I haven't filmed constantly for 2 hours, the battery has lasted very well whenever I've used it. It charges easily, and you can easily use the connection cable to transfer your content to PC or anything else after use. Deleting items is also easy, although I have to say that sometimes when transferring content to CD or DVD afterwards, I've received a card error message that just says 'check card' on the record mode, and 'error' on the play mode (which, incidentally is a completely simple toggle between a red button symbol and a play button symbol). If you get this error, I've found that the only way of eradicating this is to (safely) remove the SD card and use an external card reader to delete the folders the recordings automatically slot into.
Other than this, I've had no issues whatsoever. It's a delight to use and the quality is impressive. There are now slimmer and smaller devices which are just as powerful, and these would certainly help for portability reasons, but this is still a top notch high powered video camera, and is likely to be slightly reduced in price as there are further versions available. If you're after something where the video and audio are quality and is easy to use, then this is a good move. The zoom is the icing on the cake for me - highly impressive. A video camera with ticks in all the boxes.
My partner bought this for me as a birthday present before our son was born as we wanted to record all the special moments as he grew and this camera has done just that so far.
The camera looks slick and stylish being silver and black and looks very modern. It has a leather hand strap to keep the camera in place while recording which is very useful.
On top of the camera it has a little toggle which you can move side to side to zoom in and out while recording, it is ideally placed that it is easy to use.
The side flips out so that you can watch what you are recording and I was fascinated by this as it is so clear and the screen really is a decent size.
It comes with a charger as the recorder has a re-chargable battery it usually takes around 3-4 hours to get the battery fully charged and once it is, it seems to last a lifetime which is so handy!
To use the camera it is extremely simple and even me a techni-pobe worked it out without the instructions. It records well although sometimes it will say I am panning to fast although to me I am not moving the camera that fast! You can review what you have watched and fast forward and rewind. What I also thought was good about the camera was the sound quality on it while watching your videos. The volume turns up quite high but also everything is nice crisp and clear which surprised me.
You can also take photos on this camera, however I would warn that they aren't of the best quality and seem to have a fuzziness about them. However this didn't bother me too much as we already have a digital camera and simply wanted this to record and it does, perfectly! Would highly recommend this to others.
I confess that I had my doubts about this camcorder - for the same price, I could get a handheld "Flip" style camcorder with HD and even 3D. But I chose this camcorder because of the look of it - I've always prefered camcorders with flip out screens and hand straps.
First of all, the ability to use an SD card was a great relief - no need to mess about with proprietary hardware or any of that nonsense. I got mine in the blue colour, but the camcorder itself is not dominated by the chosen colour - lots of silver and greys in addition to the blue. I didn't like that there were so many buttons - there were buttons on the screen, the top of the device, on the side of the device - it all felt rather clustered. The camcorder will shoot in standard definition, but not high definition or in 3D - however, I did not need HD for what I was using it for. The lens is protected by a cover which slides down with a little slider, which is useful as the lens doesn't get much dust or other unpleasantly in it. Sadly, it is not waterproof - would have been a useful feature for some.
In terms of picture/video quality, it is superb - it captures clear videos and also doubles as a camera (despite the lack of flash). The zoom is phenomenal - far exceeds any other camcorders zoom at an equal price. However, as is the case with large zooms, it can get shaky when you zoom in. A microUSB port is located on the device, but the camcorder can also link into your TV (with the included cable). The file size of the videos is surprisingly low, despite the good quality - I took 90 30 second videos and it totalled up to under 1GB (I was using a 16GB SD card).
Would I recommend it to a friend? I think I would, it's one of the best standard definition camcorders I've ever had.
The design of this camcorder is one of its best features and it really does look great, especially in white which is the colour I chose. The finish is metallic which makes it look really sleek and the paint is very hard to chip - mine still doesn't have a mark on it despite relatively heavy usage indoors and out. The camcorder is light, small and comfortable to hold.
Despite being standard definition, the video quality is still surprisingly good, though unfortunately this quality is lost slightly when uploaded to websites such as youtube, so you will have to trust me on how good the quality is! There are some videos from this camera on youtube though so you can get a general idea. The video is quite soft and perfect for filming days out in the sun, and making mini films etc. The camcorder does also have an integrated camera so you can take pictures even during filming, which is particularly nice when you are trying to get a picture of something far away and you are without a tripod so a video won't cut it. These pictures are ok quality - they don't match up to a traditional camera of course but I have only used it for really far away shots so far. You will probably want to bring a camera out with you alongside this which shouldn't be a problem because as said, the camcorder is very small and literally fits in the palm of your hand.
My favourite feature on this camcorder, and the reason I opted for it in the first place, has got to be the 78x optical zoom. Optical zoom gives you much better quality than digital zoom, and this camera has a lot of both. As quite a fan of stars and space, I have been able to capture some beautiful pictures and videos of the moon and stars with this camera and some of them have really amazed. This is a major reason why you should opt for a standard definition camcorder - while the HD ones do have slightly better picture quality, the zoom just isn't up to scratch.
The sound quality is also very good and sounds crisp. If you are filming something loud it still manages to capture the sound rather than just blocky noise that is caught by some camcorders. It doesn't catch the sound of the wind much either, or at all on relatively calm days which is a real bonus.
The camcorder is also very easy to use and could be shared between a family as it is quite durable. The interface is simple but effective and anyone should be capable of using it after a couple of lessons! It also comes with panasonic studio software so you can make short films from your footage. This is good but if you want something more professional you will need to buy your own software.
The battery life is OK... nothing special. It will get you through a day out but may need a recharge after a while. The battery life does build with more use for a while so if you are going to use it alot the battery life will improve.
Overall, a very good camera and well worth the asking price. If you're looking for zoom quality over HD, this is the one to buy!
Currently retailing on amazon for £163.99 in white or more in other colours.


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National Geographic is airing an undercover exposé on animal abuse and recent "ag gag" laws on July 31. The black screen prefacing the program with the words "Viewer Discretion is Advised" will seemingly set the tone for the rest of the report.
Mariana van Zeller and Darren Foster, a wife and husband team of investigative journalists, used undercover cameras to explore the abusive animal practices at meat and dairy production farms. This undercover operation was conducted with the sponsorship of the Mercy for Animals organization.
In the preview of this program, a representative of Mercy for Animals specifically mentions hog gestation crates and castration without anesthetic as abusive practices. The ethics of gestation crates have been in question lately. Actor Ryan Gosling recently appealed to Canada's National Farm Animal Care Council to oppose the "iron maidens." American pork producers argue, however, that they should be able to choose whatever housing system is safest for employees.
This program will address many controversial issues in the agriculture industry, but the question is if the program can accurately convey the farmers' perspective to viewers. A picture is worth a thousand words, and a video may stir up even more ruckus.
In a preview to this program, a National Geographic reporter interviews Kay Johnson Smith, president of the Animal Agriculture Alliance, about "ag gag" laws, which prohibit whistleblowing and undercover journalism in agri-business.
"The American public has really a knowledge gap of farming and ranching," Smith told National Geographic. "People really don't have any firsthand knowledge of how farm animals are raised, how their food is produced, so they're very susceptible to any sort of video or representation presented by these activist groups. They are meant to create distrust and create a lack of confidence."


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Snow has brought flights to and from Bristol Airport to a standstill this morning (Friday).
All flights are currently suspended and passengers are advised to check the status of their flights by visiting www.bristolairport.co.uk/flights-from-bristol/arrivals.aspx.
In Corsham, commuters suffered traffic delays when a bus was caught in the snow at around 7.45am.
The vehicle, which has now been removed, was travelling along Westwells Road caused delays for motorists as it partially blocked the road.
The A303 south of Warminster is currently blocked with queuing traffic behind a broken down lorry.
Congestion is on the stretch of the road eastbound between the Chetcombe Road junction in Mere and the A350 turning in Kingston Deverill.
Motorists are being advised to only make necessary journeys and exercise extreme caution when travelling.
A Wiltshire Police spokesperson said: "There have been a few incidents involving people getting stuck and minor road traffic collisions but thankfully we haven't seen anything serious.
"The message would still be if your journey isn't essential then don't make it."
The police are working with the Highways Agency to ensure roads are constantly gritted.
In Bradford on Avon, the number 98 bus service, which travels between the town and Westwood, has been suspended because of the snow.
While there are delays on the M4 westbound between junction 16 for Swindon West and junction 17 for Chippenham because of an accident, with traffic travelling at around 35mph.
First Great Western is also giving regular updates about rail delays from their Twitter account https://twitter.com/FGW.


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Clinical Study Assessing Idrabiotaparinux Sodium Injections Once-weekly in Pulmonary Embolism Therapeutic Approach (CASSIOPEA)
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- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Embolism Thrombosis
|Drug: Idrabiotaparinux sodium Drug: Warfarin Drug: Placebo (for idrabiotaparinux sodium) Drug: Avidin Drug: Placebo (for warfarin) Drug: Enoxaparin
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|An International, Multicenter, Randomized, Double-blind, Double-dummy, Parallel Group, Study of 3-month or 6-month Treatment With SSR126517E (3.0 mg s.c. Once-weekly) Versus Oral INR-adjusted Warfarin in the Treatment of Patients With Symptomatic Pulmonary Embolism With or Without Symptomatic Deep Venous Thrombosis
- Recurrence of symptomatic, fatal or not, VTE (PE or DVT) as confirmed by a Central Independent Adjudication Committee (CIAC) [ Time Frame: 3 months ]
- Recurrence of symptomatic, fatal or not, VTE (PE or DVT) as confirmed by a Central Independent Adjudication Committee (CIAC) [ Time Frame: 6 months ]
- Incidence of any clinically relevant bleeding as classified by the CIAC (ie, major bleeding and other clinically relevant non major bleeding) [ Time Frame: 3 months, 6 months and 3- to 6-month post-treatment follow-up ]
|Study Start Date:
|June 2006
|Study Completion Date:
|October 2010
|Primary Completion Date:
|October 2010 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Idrabiotaparinux
Idrabiotaparinux sodium, 3.0 mg, once-weekly for 3 or 6 months depending on the stratum, after enoxaparin, 1.0 mg/kg, every 12 hours for at least 5 days.
Avidin, 100 mg, at the discretion of the investigator whenever deemed appropriate and possible (ie, life-threatening bleeding, emergency invasive procedure with the potential of uncontrolled bleeding, or over-dosage).
Drug: Idrabiotaparinux sodium
0.5 mL pre-filled syringe for 3.0 mg
Subcutaneous injection
Other Names:Drug: Avidin
100 mg in 10 mg/mL solution
Intravenous infusion for 30 minutes
Other Name: SSR29261Drug: Placebo (for warfarin)
Drug: Enoxaparin
Warfarin matching capsules
Oral administration
Prefilled syringes as locally registered
Subcutaneous injection
Active Comparator: Warfarin
Warfarin, INR-adjusted dose, started 24 hours after the start of enoxaparin, 1.0 mg/kg, every 12 hours for at least 5 days, and continued for 3 or 6 months depending on the stratum.
Avidin, 100 mg, at the discretion of the investigator whenever deemed appropriate and possible (ie, life-threatening bleeding, emergency invasive procedure with the potential of uncontrolled bleeding, or over-dosage).
Drug: Warfarin
Drug: Placebo (for idrabiotaparinux sodium)
Capsules with 1 or 5 mg for INR-adjusted dose (INR checked at least once a month)
Oral administration
Drug: Avidin
0.5 mL pre-filled syringe
Subcutaneous injection
100 mg in 10 mg/mL solution
Intravenous infusion for 30 minutes
Other Name: SSR29261Drug: Enoxaparin
Prefilled syringes as locally registered
Subcutaneous injection
Detailed Description:
Treatment with a therapeutic dose of any low molecular weight heparin (LMWH) or unfractioned heparin (UFH) or fondaparinux is allowed only within the 36 hours immediately preceding randomization. Randomization is performed as soon as the diagnosis of PE (and DVT if concomitant suspected symptomatic DVT) is confirmed.
Allocation to treatment is done centrally by Interactive Voice Response System (IVRS) and stratified by (1) center, (2) intended treatment duration, ie, 3 months or 6 months. At randomization, the planned duration of treatment (3 or 6 months) is prespecified by the Investigator and determined on the assessment of risk of VTE recurrence. Participants are randomized to either idrabiotaparinux + placebo of warfarin, or warfarin + placebo of idrabiotaparinux, with an initial treatment of at least 5 days with enoxaparin in both treatment groups.
Participants in the 3-month stratum have an additional 13-week observational period after cessation of study treatment. Participants in the 6-month stratum have a 13-week up to 26-week observational period.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Symptomatic pulmonary embolism with or without symptomatic deep vein thrombosis
Exclusion Criteria:
- End stage renal failure, hepatic failure, uncontrolled hypertension;
- Active bleeding or high risk for bleeding;
- Pregnancy or childbearing potential without proper contraceptive measures, threatened abortion.
- Breastfeeding.
- Known allergy to idraparinux or idrabiotaparinux, avidin or egg proteins;
- hypersensitivity to warfarin, enoxaparin, heparin or pork product; or any other contraindication listed in the labelling of warfarin or enoxaparin;
- Indication of prolonged anticoagulation therapy for other reason than PE;
- Life expectancy < 6 months;
Please refer to this study by its ClinicalTrials.gov identifier: NCT00345618
Show 38 Study Locations
|Study Director:
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT00345618 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 27, 2006
|Last Updated:
|February 19, 2016
Keywords provided by Sanofi:
Deep venous thrombosis
pulmonary embolism
anticoagulant drugs
Additional relevant MeSH terms:
Pulmonary Embolism
Venous Thrombosis
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases
Lung Diseases
Respiratory Tract Diseases
Vitamin B Complex
Growth Substances
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


text:
Maastricht Biomarker CT Study
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- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Cardiovascular disease is the leading cause of death in the Western world. The main cause for cardiovascular events is the development of atherosclerosis in the coronary arteries. In more than 70% of cases, myocardial infarctions are caused by atherosclerotic plaque rupture, which results in subsequent formation of an occluding thrombus. Plaques that have a high risk of rupture are called vulnerable plaques. Cardiovascular imaging provides a complementary diagnostic approach in the assessment of cardiovascular risk in patients. However, the lack of biological detection possibilities of current imaging technologies limits their predictive value. For instance, multi detector computed tomography (MDCT) is an excellent tool to visualize coronary atherosclerosis. However, individual risk assessment is still problematic. Which of the diagnosed atherosclerotic plaques will undergo plaque rupture and lead to acute vascular events is currently hard to predict. Potentially, serum biomarkers could help identify the patient at risk. A wide variety of prognostic markers related to atherosclerosis have been identified in the past to predict for cardiovascular events. Nevertheless, their predictive value in individual patients is still limited. A difficulty in serum biomarker research is the requirement of large patient cohorts to study the relation between event rate and serum biomarker levels. The necessity to perform lengthy and costly studies, hinders the translation of novel cardiovascular serum biomarkers into the clinic. An alternative approach could be to study the correlation between levels of serum biomarkers and the presence of atherosclerosis in the coronary arteries.
Study objectives
Primary objective of the present analysis is to investigate the predictive value of a variety of serum biomarkers to predict atherosclerosis in the coronary tree of patients undergoing cardiac MDCT.
Design and Methods
Patients undergoing cardiac MDCT are eligible for the study. Excluded are patients with acute coronary syndrome, hemodynamic instability, pregnancy, severe renal insufficiency, allergy for contrast medium and inability to obtain informed consent. Permission to store the serum samples for future analysis of new prognostic markers for cardiovascular events will be acquired from the patients. Written information is send to the patient at least 1 week prior to CT. The samples will be stored coded, at the Biobank Maastricht, for a maximum duration of 15 years. Once measurements from the samples will be performed, the serum samples will be sent by the Biobank coded to the analyzing researchers, which have no access to the key file where codes are linked to the specific hospital identity number. This file will be stored by an independent researcher at the Cardiology department of the Maastricht University Medical Center. The assessment of atherosclerotic burden of the coronary tree will be performed by cardiac MDCT specialists blinded to the clinical data and serum biomarker outcome. Biomarker levels are correlated to the severity and amount of coronary artery disease as assessed by cardiac MDCT.
|Coronary Artery Disease Coronary Stenosis
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:
|Maastricht Biomarker CT Study. Relation Between Cardiovascular Biomarkers and Coronary Atherosclerosis in Patients Undergoing Multi Detector Cardiac Computed Tomography.
- coronary artery disease [ Time Frame: 1 year ]
- The presence of any coronary atherosclerotic plaque as visible on cardiac CT.
- The presence of any significant (≥50% luminal stenosis) coronary plaque in the coronary tree.
- The number of atherosclerotic plaques in the coronary tree.
- The calcium score (Agatston method).
- Plaques are categorized as calcified (exclusively content with density >130 Hounsfield units), non-calcified (exclusively content with density <130 Hounsfield units), or mixed (characteristics of both calcified and non-calcified plaque).
|Study Start Date:
|April 2007
|Study Completion Date:
|January 2014
|Primary Completion Date:
|January 2014 (Final data collection date for primary outcome measure)
cardiac computed tomographic angiography
Patients refered for cardiac computed tomographic angiography by a cardiologist.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- patients refered to cardiac computed tomography to exclude coronary artery disease
Exclusion Criteria:
- pregnancy
- severe renal insufficiency
- severe allergy to contrast medium
- Inability to obtain informed consent
- Age below 18 years
Please refer to this study by its ClinicalTrials.gov identifier: NCT01671930
|Maastricht University Medical Center
|Maastricht, Netherlands, 6202 AZ
|Principal Investigator:
|H Crijns, M.D. P.h.D.
|Maastricht University Medical Center
|Study Director:
|B Kietselaer, M.D. P.h.D.
|Maastricht University Medical Center
|Study Chair:
|L Hofstra, M.D. P.h.D
|Maastricht University Medical Center
|Responsible Party:
|Maastricht University Medical Center
|ClinicalTrials.gov Identifier:
|NCT01671930 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 21, 2012
|Last Updated:
|May 26, 2014
Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Coronary Stenosis
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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that my system is Windows 7 64-bit. Perhaps another solution is to download Google Chrome, and then delete IE? (I'm not tech-savvy.)
After reading Seth Rosenblatt's review of IE10, I downloaded it. Adobe Flash Player immediately struggled, so I deleted it and tried to download it fresh, but can't. Rather than being given the option to "run" or "save", I'm being given the option to "open" or "save", and clicking on either seems to do nothing. I had the same problem trying to update Malwarebytes. How can I go back to IE9? Or has anyone solved similar problems with IE10?


text:
This is the complete transcript of a post I made two days ago. This has more information.
Transcript: Larry Birds Pre-Draft Briefing
July 23, 2005
Pacers President Larry Bird met with the media for an informal question-and-answer briefing about the Pacers' plans for the June 28 NBA Draft. What follows is a transcript of that session.
Q: Since you have the No. 17 pick how difficult do you think it will be to get a guy that can contribute?
A: Well, its just not an issue at all because I think there are going to be at least four guys there that I think can make an impact on our team, and thats all I can ask for.
Q: Do you have a sense of whether or not this years draft is deeper than last years?
A: My feeling about this draft is, you got your main guys like (Andrew) Bogut, (Marvin) Williams and some other ones in the top five or six, but after that, all the guys to me are basically the same, theyre all great players. All the way up to probably 20. There will be some steals in this draft and its a little different, theres no really clear-cut (definition between the players), after I think number five. You could draft a guy at 17 that could be better than the number six pick in the draft.
Q: Hypothetically, if you had the No. 1 pick who do you like better between Bogut and Williams?
A: Well, I would take Bogut for our team, but I like Marvin Williams, Ive seen him play in high school and hes very talented. Is he ready for this, who knows? But, hes going to be a good one.
Q: Do you have a position youre looking to fill right now?
A: Not really. I think what Im hearing now is that theres a group of four or five guys, most of them are different positions, and I think well get a kid that hopefully after All-Star break, when you put him in the lineup, hell be able to do things that a coach wants him to do. I mean, I think hes really going to help us.
Q: What is it that makes Bogut unique for this years draft?
A: Well, he can play some center but I dont know if hes a real center, its according to where he goes. If he goes to Milwaukee hell have to play the center position, but hes very skilled, he can use his left and right hand, he knows how to play, he can pass out of the post, he will be a very solid player.
Q: Would you be interested in moving up in the draft, or are you still satisfied with the 17th pick?
A: Well, if we stayed at 17 I would be satisfied because theres a group of players there that whoever we take there is going to help our team. But we had some calls about moving, trading and moving up, but some of the guys theyre asking for I dont want to give up on them. So, right now, it seems like theres a good possibility were going to stay there, but if we can get up there and get a player we know can step right in and make a big impact on our team, yeah, well probably try to do that.
Q: How likely is it that you will pick a European player?
A: Marko Tomas got out of the draft, who I really liked, he wouldve been probably around 15-20, 22. I really liked him, Ive seen him play you know for the last two years, some of the big guys Im not really impressed with, theyve got a long ways to go. Theres a point guard, (Roko) Ukic I think is his name, very good, a lot of size, hes still in the draft, but, theres some good players, but a lot of the best players pulled out.
Q: Do you feel like the personal time you spent in Europe watching players was wasted since a lot of them have pulled out?
A: No, not really. I really feel now, the kids, the young kids, the next great group is coming from Russia. And theyre still 17 16, 17, 18 years old. One of them is going to be in the draft this year, I think hes going to be a tremendous player, (Yaroslav) Korolev. But, you know, its going to take time.
Q: It seems like theres a lot of talk surrounding the three point-guards that will probably be taken in the top ten, but since this is a very deep point-guard class, do you still think you will be able to get a good one?
A: Theres no question about it. I mean youve got Paul, Williams and Felton and all three of them are very good players. You know Ive seen some mock drafts where Felton might slip to 10 or 12, but I dont know if I believe that. I think hes good enough to be in the top seven or eight players taken. So this is a deep draft for point guards.
Q: Since youve lost your shooting guard in Reggie, what shooting guards are out there that you like?
A: Marko Tomas. (Francisco) Garcia is in the draft, Marko Tomas, I really like Luther Head which I think can play point guard. Theres a number of players, (Rashad) McCants is out there, a very talented player, but you know its just according to who is going to be in that group when we select. I mean, I might take a point guard, I may take a two, I dont know yet its according to who is left.
Q: How much do you weigh the players character when considering them for the draft?
A: Well, like Rick Carlisle says, we dont want a bunch of milk drinkers here. Well take the good with the bad, but Ive known Rashad for a couple of years, Ive talked to him, Ive been in to watch him practice and hes a very, very talented player, so, well see what happens.
Q: Are there any really good shooters out there that can come in and stroke it from the perimeter?
A: You know all the guys weve had in, weve had Garcia in, weve had Luther Head in, weve had a number of guys in and every one of them have shot the ball extremely well. I know Garcia, Ive seen him play a lot of times. I know Luther Head, everyone knows about Luther and how well he can shoot it. Theres a number of guys out there that can put the ball in the basket.
Q: Are you geared more towards the backcourt in this draft than the frontcourt?
A: Well, I cant say, because things change, its according to who is there. We feel we have some areas where we feel were getting better in. And, theres going to be a group of guys there when we select and I think we have it pretty well figured out who is going to be there. And we just got to make the decision on which one we want.
Q: What skills are you targeting?
A: Somebody that can help us. Somebody better than what we've got, and we've got some good players.
Q: Where is Sean May in the draft, do you think hes slipping?
A: Well, he could be there when we draft. Hes one of the guys that Ive got picked out from the group that might be available when we draft, but if theres a team that really likes him at nine or 10 theres still going to be another great player there dropping down to us. You know, its hard to get all these guys to come in for a workout but, Im not really big on that since weve watched them play so much throughout the year. But, we do like at least for them to come in and sit down and talk with them.
Q: There has been a trend for the team to take college players, is that a philosophy of the team or just a coincidence?
A: Well, I mean its funny, you look at the guys that have gone to college for a few years and compare them to some of these young kids that are coming out that think they should be playing 40 minutes a game, its a little different. And at one time we had two high school players here, they were great guys, had a great work ethic, but you know, they always wanted to play more and do more. Whereas, a guy like James Jones comes in and you dont have to worry about him. Hell play whatever role, you know he wants to play all the time but he still accepts the roles that hes in, so, I always think if you can get a guy or a college player who's been in school for three or four years, I think its to your advantage to probably look at him and probably draft him.
Q: Does that mean youre more likely to pick a college player in this draft rather than a high school player or a European?
A: Well, if Gerald Green is there we will take him, but other than that well be looking for someone with great talent and someone who went to college for a few years.
Q: How do you see Sean May's game projecting to the NBA level. What do you think his strengths and his weaknesses are?
A: Well, I think hes got all the tools. I think his ability to rebound, hes an intelligent player, hes got great hands, the only problem he may have in this league, but I doubt it, is it wont be as easy to get his shots off as it was in college, hell be contested almost every time, but smart players and good players have the ability to adjust their game and overcome all of that, and I think he is one of those players.
Q: How dramatically did the players that withdrew affect your plan?
A: Not at all. Rudy Fernandez, Joe (Ash) has been watching him for years; hes going to be a very good NBA player in the future but hes just not strong enough yet. If we had taken a guy like that we would have had to wait two or three years before he was able to come in and help us. Tiago Splitter, hes another kid, a couple of years in Europe and hell be fine. But, its just according to what you need I guess, and theyre just not ready yet. In my mind theyre not ready to play here yet, but theyre very talented.
Q: What are the chances that the guy youre going to get is going to make the team, let alone help the team?
A: Oh, hes going to make the team, were confident enough that the guy were going to get is not only going to make our team, but is going to play-- even if I have to coach him.
Q: Where do you see Chris Thomas and Bracey Wright?
A: I dont know. You know, weve got the 46th pick right now in the second round, will they get there, I dont know. I know Bracey had great workouts, he played very well in Chicago. Chris Thomas struggled at times, but weve seen enough of him to know what he does well. So, its really hard to project guys like that. Right now were concentrated on the first round and later on this week well start getting in on the second round and well find out where guys will be going.
Q: Do you think Bracey made a mistake entering the draft early?
A: No, he made a decision, whether its good or bad hes going to have to live with it. But Braceys a good basketball player, Ive seen him play a number of times, hes a great kid and you know I wish him well, but he played great in Chicago, he opened a lot of eyes, so that really helped him.
Q: Are you more comfortable this year in the draft process since you were involved last year?
A: Well, Ive been involved in this for a number of years, you know in Boston I went through all this, but you know its a long process. Theres a lot of travel, and you see a lot of games, a lot of tapes. But, Im confident this year we will get a player that can help us and thats all that you can ask for.
Q: Is that typical to have the kind of confidence you have from within the team?
A: Well, with the draft this year, like I said earlier, you got the five or six guys, you know where theyre going to go and from that point on, there to 20, the guy at 20 could be better than the guy at six, so hopefully you can get a guy that you like and when he comes in and hes able to play for your team, especially a team thats very strong like ours, thats nothing but a major plus, its awesome and we will get a good player. Im very confident in that.
Q: Are you surprised that there is a Game 7 being played in the NBA Finals?
A: Not really. I mean if you look at both teams out there, and you always talk about chemistry and guys not worrying about stats, just playing, you know maybe thats the reason these two teams are in the Finals. Its very simple, when youve got a team that really comes together and plays as a team and does everything as a team they do it for a reason. And its to get to the NBA Finals and have a chance to win the world championship. Im not surprised by either team. You talk to Detroit and they always say they dont have any superstars on their team but they have a lot of great players on their team. You look at Tim Duncan, and other than that, theyre a team. And thats what were trying to stress with our guys the last couple of years, that its not about stats, if you really want to win the whole thing its about playing together and being a team and having the right chemistry.
Q: Why is there not a lot of talk about trade activity floating around and why is this the period of time when you would be active?
A: We are active, but I dont call you up every day and tell you what were doing. But its one of the busiest times, a lot of work goes on here to try to figure out the draft, if you can move up or if you can move down, and everyones trying to get players to make their teams better, but we dont like to have a lot of our information out there. Were not trying to hide anything, but if you have two or three players that you really like, if you have to move up to get one of those guys you do that, but right now sitting at No. 17, I know were going to get a good player. So you know, why should I sit here and tell you who we want?
Q: How willing are you to alter the roster as it is now?
A: I dont want to give up too much. I like our team, obviously I think we got some needs, we've got to get better in some areas, but I dont want to give up a good player thats really helped us out in the last couple of years just to move up four or five spots in the draft. Because I know next year that player will be very valuable to us. And you dont know how valuable they are until you move 'em and you let 'em go. I think its a very important process to just add pieces and make ourselves better. I dont want to trade away some guys just to move up in the draft and get a guy at 14, when you could have gotten him at 17.
Q: Last year you made an effort to move up because Al Harrington asked to be traded. Are you not doing that this year since no one has said they want to leave?
A: Oh theres a couple that want out of here. Not really, Im just teasing. Last year was different, I mean Al made it known that he would like to move on, get more playing time and we couldnt give it to him here. This year its a little different our main core, our main group of guys, we like them. Do we have to get better and put better people around them? Were going to try to do that.


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High-profile magazine shines spotlight on Oregon wines
PORTLAND, Ore. - Oregon's profile as a top wine producer just got a boost with the latest issue of Wine Spectator magazine.
The February 28 issue, which hit newsstands on Tuesday, includes a full feature, "Delicate Delights," on Oregon's famous pinot noirs penned by reviewer Harvey Steiman.
Talk about a tough job: Steiman said he reviewed over 550 wines from Oregon in his article. He also notes the challenges, especially with weather, that grape growers face in Oregon and how it varies the flavor of Oregon wines.
And while Steiman picks his favorites and best values, he also gives over 250 Oregon vintages a rating of 90 or above - "outstanding" - on a scale that peaks at 100. Some wines scored as high as 95.
Oregon is perhaps most famous for its pinots, but American Winery Guide also has high praise and guides to finding other types of Oregon-born vino and the wineries where they are made.
The Wine Spectator story also includes a map of Oregon's wine-producing regions, the majority of which are in the Willamette Valley and stretch to the California border, but also include eastern Columbia River Gorge regions and areas along the Idaho border.
At Liner & Elsen Wine Merchants in Northwest Portland, it's been hard to keep up with the demand for the wines featured in the article. It's already sold out of most of those wines featured in the magazine.
"It means a lot in that people spend a lot of time reading about the wines, and they may not have a chance to taste them, especially if they're buying out of state," said owner Bob Scherb. "I think many people depend on those scores to make a buying decision. So once they read about those wines, they're after them."
Since moving out to Oregon to get into the wine business 15 years ago Scherb's seen Oregon slowly stealing the wine spotlight with articles like the one in Wine Spectator.
"I think this kind of article and some of the others I've read have kind of put Oregon on the map in a way they've never been on a map before, and I think it's great," Scherb said.
Six of the 15 wine regions in Oregon are in the Portland area: The Willamette Valley, Chehalem Mountains, Yamhill-Carlton, Ribbon Ridge, Dundee Hills and McMinnville.
High marks doesn't necessarily mean a big price tag. There were some 90-point plus wines on the list selling for about $13.


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Irradiated fresh pitaya — dragonfruit — and pomegranates from Mexico should be allowed into the U.S., according to a new pest risk assessment from the U.S. Department of Agriculture.
The notice of a pest risk analysis for Mexican fresh pitaya and pomegranates was published in the Federal Register Aug. 2. Comments will be taken on the document until Oct. 3, according to the agency.
In the pest risk assessment, the USDA said fresh pitaya and pomegranates can be safely shipped to the U.S. if they are irradiated first. After taking comments on the pest risk assessment, the agency said it would announce its decision regarding the import status of the fresh pitaya and pomegranates in a later notice.


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Sophia is a super cuddly chi! She is super smart and is crate trained. She may be tiny but she plays with dogs of all sizes! Apply to bring Sophia home today!
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text: Show Hide image Culture 6 June 2012 Peter Hennessy — The Books Interview The eminent historian and "Never Again" author on Thatcher, Blair, Brown, "overmightiness", hindsight and the role of historical advice in politics. Sign up for our weekly email * One of the themes of your latest book, Distilling the Frenzy, is the danger of passing off "contemporary prejudices in fancy dress" as history. Is it one to which you've ever succumbed? The danger for me, which I have to watch, is that when I get a run of cabinet committee minutes I have to resist the temptation to heckle them, saying, "Come on, wait a minute, it wasn't that simple even then!" That's my besetting sin: wanting to heckle retrospectively. You observe that all historians write from a particular historical vantage point – in your case, it's 1961. So, is the history you do a matter of explaining how we got from there to here? There's always an element of that, because you want to try to make sense of it to yourself, and also to your own age group. It's what Melvyn Bragg calls "generational kinship". It's a desire to explain the world to yourself, your age group and the generations younger than you. But also to do justice to the people on whose shoulders you stand – the Attlees of this world, the Bevans. You are particularly interested in the office of prime minister. One of the paradoxes of the premiership is that it has a tendency to "overmightiness", even though the occupants of No 10 rarely feel powerful. Those who are on the receiving end of excessive prime ministerialism certainly feel it. But I remember when Mrs Thatcher was at her height she had a seminar on management – Michael Heseltine's pioneering stuff at the Department of the Environment. Michael presented at the seminar, and the other ministers, or the vast majority of them, resisted. When it was all over she said to a friend of mine, "Why won't they do what I want them to?" Yet Thatcher's was one of the two "command premierships" of the postwar period. The other was Tony Blair's. Yes, but there's a big difference. Margaret liked to get her way after a bloody good argument. Tony didn't like the argument. Margaret's style was to declare, in her opening remarks, the conclusion she wanted, and almost defy other people to defy her. But she wasn't happy until they'd had a go at knocking her off her position. She really did love the biff-biff of cabinet government but Tony didn't. And that's a big difference. Has cabinet government recovered at all from the pummelling that it took under Blair? It's recovered quite a lot. I think if David Cameron was on the end of the phone, rather than me, and you put that question to him, he would say he wanted to restore an element of cabinet government, that he didn't want to be like Gordon or Tony. I never accepted the argument that one got in the Blair years, that 24-hour media and the nature of the world, the nature of the markets, mean that you can no longer have the leisure of collective discussion. My toes always curl when I hear these justifications for taking short cuts with collective cabinet government, because, in a country without any institutional checks and balances, the potential for overmightiness in No 10 is always there. The problem is, if you get a destiny politician in there – someone who thinks that he or she is indispensable to his or her party, the country, Europe, or the world – you're in deep, deep trouble. Do you wish that historians were more involved in government and policymaking? William Hague made a very good speech last year about getting historians back into the system. They've got very good in-house historians at the Foreign Office and a good research department. I think there should be a chief historical adviser to the Prime Minister. You need someone who's got the bandwidth, who's got, as Enoch Powell said, the "800 years". Even 60 years would be a start, wouldn't it? In a way it would, although to understand, for instance, the deep-set problems of British industry and competitiveness, you have to go back to the Great Exhibition of 1851. There are certain things in Britain that are very, very deep-set. Peter Hennessy's "Distilling the Frenzy: Writing the History of One's Own Times" is published by Biteback (£18.99) Jonathan Derbyshire is Managing Editor of Prospect. He was formerly Culture Editor of the New Statesman. Subscribe from just £1 per issue This article first appeared in the 11 June 2012 issue of the New Statesman, A-Z of Iran More


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Income Tax - Individual Taxation - Knowledge Direct
The new 0% rate of tax on Savings Income
With effect from 6 April 2015 the starting rate of tax for savings income was reduced from 10% to a zero rate. In addition, the savings rate band was increased from £2880 per year to £5000 and the ability to claim tax free interest was introduced but what does this all mean to investors?
For anyone who has earned income of less than £15,600 per year they will be entitled to tax free interest on their savings up to the £15,600 limit, ie the £10,600 personal allowance and £5,000 savings income band.
Where total income including savings income is less than £15,600 in any tax year it is possible to register to receive interest on bank and building society savings tax free and avoid the need to reclaim the tax suffered. In circumstances where the income will exceed £15,600 but an element is entitled to the zero rate it is not possible to register to receive interest tax free but the tax deducted can be reclaimed.
Steve has employment income of £12,000 and receives interest on his building society savings to the sum of £2000 each year.
As his earned income and savings income together do not exceed £15,600 not only is he entitled to the zero rate of tax on his savings but he can register to receive his interest tax-free.
Steve can register to receive his interest tax-free by making a claim to HMRC using form R85.
Joan has employment income of £14,000 and receives interest on her bank savings to the sum of £3,000 each year.
Whilst Joan is entitled to the zero rate of tax on £1,600 of her savings income she cannot register to receive this tax free because she has an element that is liable to tax at 20%.
Joan can reclaim the tax suffered on the £1,600 by making a claim to HMRC using form R40.
The increase in the savings income band and the introduction of the zero rate of tax is good news for offshore bond Investors.
Gains from life assurance policies are treated as savings income within Chapter 9 of Part 4 Income Tax (Trading and Other Income) Act 2005, however, when considering the order of taxation, there is a hierarchy to consider. Gains from onshore investment bonds are always taxed as the highest slice of income whereas chargeable gains arising from offshore bond investments fall within the "savings income" bracket and as such may fall within the savings income band.
Order of Taxation:
Jonathan's pension income is £10,000 and he wishes to supplement this by taking a regular withdrawal of £10,000 per year from his offshore investment bond.
He invested £100,000 into his bond which would provide a 5% tax deferred allowance of £5,000 per year. As his withdrawal will exceed this he will incur a chargeable gain of £5,000 each year.
However, as the gain, when added to his pension income keeps his income under £15,600 he will have no tax to pay on the withdrawal:
Total Income: £15,000 (£10,000 + £5,000)
Tax Rate
Tax to pay
@ 0%
If Jonathan's pension income was £13,500 instead and he continued with his withdrawals of £10,000 per year from his offshore bond and incur a chargeable gain of £5,000 each year his tax liability would be:
Total Income: £18,500 (£13,500 + £5,000)
@ 20%
Frank is married to Karen and they have twin boys Joshua and Sam aged 19. Frank inherited £500,000 14 years ago when his mother died which he invested into an offshore bond with Old Mutual International (Isle of Man) Ltd and his fund is worth £1,000,000 now.
Frank has decided that he would like to make annual withdrawals from his investment for Karen and the boys to provide Karen with a small income and to supplement the boys' income whilst they are at University.
Frank is a higher rate tax payer earning £75,000 per year; Karen only has a small income of £9,500 per year from her part-time job, the boys are also working part time whilst at University and each has a small income of £4,000 each year.
The original investment was split into 500 individual policies. The most tax efficient way to withdraw capital is to assign individual policies to Karen and the boys prior to their encashment. Frank decides to assign 4 policies to each of them in the tax year 2015/16. He has made no previous withdrawals.
Chargeable gain per withdrawal of 4 policies: £2000 - £1000 = £1000 gain x 4 policies = £4,000.
Tax liability for Karen:
Total Income: £13,500 (Taxable income £9,500; chargeable gain £4,000)
Tax liability for each of Joshua and Sam:Total Taxable Income: £8,000 (£4,000 taxable income; chargeable gain £4,000)
£8,000 (within personal allowance of £10,600)
If Frank had withdrawn the proceeds from the 12 policies in his own name the tax liability would have been £4,800 (£12,000 chargeable gain x 40%).
As an alternative Frank could have chosen to make the withdrawals as partial withdrawals across all policies within the 5% tax deferred allowance, however, as the proceeds are for the benefit of Karen and the boys and they can all take advantage of their personal allowances and the £5,000 savings income band this is the most tax efficient solution in this situation. It crystallises the gain at the time of the withdrawal.
These examples show that whilst chargeable gains may arise where withdrawals are made from offshore investment bonds careful consideration and planning can ensure that the withdrawals are as tax efficient as possible.
Gains from onshore bond investments cannot benefit from the savings income band because basic rate tax is already deemed to have been suffered within the investment and this cannot be reclaimed under any circumstances.


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I am new to Disc Golf and to this board, so go easy on me!! I am 52 years old and started playing this summer. After much reading on this board I've gravitated to Leopards as drivers and am getting 250' typically, so I'm no distance monster.
Based on what I've read here I decided to get a couple of Comets and practice shorter shots to help my form. I am currently in South Texas where wind is a constant. During my practice evenings the wind is typically 10-20 mph. With the wind at my back I get smooth, straight throws, but when I throw into the wind the Comets turn over badly and finish way right (RHBH). If I start them on a moderate hyzer they will usually flatten and fly straight. BTW - I also practice with a Buzzz and a Roc, and these exhibit some of this same behavior, but to significantly lesser degrees.
So my question - Is this the expected behavior or does it point to a flaw in my technique?


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Topic: Just say Hi from ASCO 2012
Hi, everyone,
Nice to see karen in the first day at RAN; I have attended a few seminars for about 6 hours; the first one on new drugs that are recently approved by FDA or will be approved soon but NONE is for liver cancer or CCA. the names are Vemurafenib,Crizotinib,Brentuximab,Abiraterone,Ipilimumab,Axitinib and Vismodegib.
I will have a more detailed report after the convention. One thing I found out is that drugs that used on the patient does not always shows improvement of the disease state(ie; shrinkage of the tuorm) at the onset of the regimen;as a matter of fact ,for example the targeted drug called Ipilimumab(ILi) after the first two weeks of treatment ,PET scan shows increase in size of the tumor;but if the doctors do not stop the drug and continue to use it; in 6 month later,PET scan shows tumor shrinkage in size which is much smaller than before the start of the Ipilimumab. that is why as a patient,you have to be treated by oncologists who keep his/her knowledge up to date. (most of doctors will discontinue the treatment of Ipi after it shows increase in tumor size if he is not keep his/hers practice current.)
I have also attended a seminar talking about Liver mets; it is mostly based on the Barcelona scale. For unresectable liver cancer, they use TACE(ie;chemoembo);or Nexavar( sorafenib) for advance liver cancer; they also use Nexavar+TACE and found that if patients give Nexavar 7days BEFORE TACE treatment and continued afterward , the result is BETTER than give Nexavar AFTER TACE and continue on Nexavar.
Talk to all of you later.
God bless.


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Professor, Department of Medicine (Critical Care)
Professor, Department of Anesthesiology
Associate Professor, Department of Surgery
Material in this section is provided by individual faculty members who are solely responsible for its accuracy and content.
Montefiore Medical Center
210th Street & Bainbridge Ave.
Bronx, NY 10467
The Wall Street Journal profiles critical care medicine at Montefiore Medical Center, the University Hospital and Academic Medical Center for Einstein.
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