text:
- For this character's human counterpart, see Fluttershy (EG).
Fluttershy – element of kindness
Fluttershy as a filly in The Cutie Mark Chronicles
|Outside of Ponyville, in a cottage near the Everfree Forest
Cloudsdale (formerly)
|Animal caretaker
Pony Tones singer (part-time)
|Other links
|More info
| Moderate cyan
Brilliant amaranth (as a vampire fruit bat-pony)
| Pale, light grayish rose
Pale, light grayish rose with light rose, pale, light grayish mulberry, pale, light grayish opal, and moderate opal streaks (Rainbow Power)
|Pale, light grayish gold
|Klutzershy, Flutterguy, Stare Master, Mare Do Well, Shutterfly, Saddle Rager, Flutterbat, Flutterdash, Flutterbutter, Opposite Fluttershy, Impossibly Rich, Flutterbold, Yellow Daisy, Fl (The Periodic Table of My Little Pony)
|Zephyr Breeze (younger brother)
Mr. Shy (father)
Mrs. Shy (mother)
| Cutie mark
|Andrea Libman (English)
Brittany Lauda (English, My Little Pony: Fluttershy's Famous Stare[1] and My Little Pony: Power Ponies) [2]
Lin Peiling (Mandarin Chinese for Taiwan)
Luo Yuting (Mandarin Chinese for China mainland)
Šárka Vondrová (Czech)
Klára Jandová (Czech, demo version)
Katrine Iven Strømsted (Danish)
Lizemijn Libgott (Dutch)
Susa Saukko (Finnish)
Elisabeth Guinand (European French)
Audrey D'Hulstere (European French, season 4)
Julia Stoepel (German)
Zselyke Szabó (Hungarian)
Benedetta Ponticelli (Italian)
Emiri Katō (Japanese)[3]
Lee Ji-young (Korean)
Benedikte Kruse (Norwegian)
Sarah MacDonald Berge (Norwegian, demo version of S1E3)
Małgorzata Szymańska (Polish)
Priscila Ferreira (Brazilian Portuguese, seasons 1, 3, Equestria Girls, and from Rainbow Rocks onward)
Kate Kelly (Brazilian Portuguese, Season 4)
Bianca Alencar (Brazilian Portuguese, demo version of S1E3)
Ioana Dagău (Romanian, seasons 1-3)
Denisa Chis (Romanian, season 4)
Anca Iliese (Romanian, Equestria Girls)
Olga Golovanova (Russian)
Jelena Jovičić (Serbian, Minimax)
Aleksandra Tomić (Serbian, Mini)
Carmen Ambrós (European Spanish)
Maggie Vera (Latin American Spanish, TV version)
Mireya Mendoza (Latin American Spanish, S1E3 (demo version) and promos)
Lizette Pålsson (Swedish)
Natalya Romanko (Ukrainian, seasons 1-4, Equestria Girls, and Rainbow Rocks)
Yulia Perenchuk (Ukrainian, seasons 5-6)
As Flutterguy:
Blu Mankuma (English, S1E9)[4]
Alvin Sanders (English, S4E14)
Gerald Paradies (German)
Mario Scarabelli (Italian)
Katsuhisa Hōki (Japanese)
Shi Yeong-joon (Korean)
Simen Sand (Norwegian)
Adam Krylik (Polish, S1E9)
Nikita Prozorovsky (Russian)
Marko Marković (Serbian, Minimax TV dub)
Sebastían Llapur (Latin American Spanish)
Joakim Jennefors (Swedish)
Yaroslav Chornenkyi (Ukrainian)
|Antonie Talacková (Czech, season 3)
Roberta Bartůňková (Czech, season 4)
Bori Csuha (Hungarian, season 1 and films)
Zselyke Szabó (Hungarian, season 2 and S3E13)
Tímea Sági (Hungarian, S3E1-2)
Bernadett Vágó (Hungarian, season 4)
Mônica Toniolo (Brazilian Portuguese, season 1 and Equestria Girls)
Vânia Canto (Brazilian Portuguese, season 2)
Andressa Andreatto (Brazilian Portuguese, season 3)
Vera Calacoci (Italian, Find A Pet Song)
Maria Ivaschenko (Russian, season 5)
Polina Mingalevich (Russian, season 6)
Anna Orra (European Spanish, season 2-3 and Equestria Girls)
Dámaris Aragón (European Spanish, season 4)
Nancy Philippot (European French, Find the Music in You reprise)
Alina Leonte (Romanian, S4E14)
Jelena Petrović (Serbian, Mini)
As Flutterguy:
Marcus Mosley (English, S4E14)
Antônio Moreno (Brazilian Portuguese, S4E14)
Lauren Faust was inspired to create Fluttershy by her childhood toy G1 Earth pony Posey.[5] Fluttershy's initial design, published online by Faust, refers to her as "Posey" as well. Her cutie mark, three pink and cyan butterflies, is similar to that of the G2 pony Sky Skimmer.
Fluttershy's name is shared by a previous generation Earth pony, who is a photography enthusiast. The guidebook The Art of Equestria reveals some of the other names Lauren Faust considered giving her, including "Summer Azure (Summer for short)", "Spring Blossoms", "Petalwing" and "Meadowbrook";[6] the last of these four is the same as that of a G3 Earth pony and—after Faust's departure from the show—was eventually given to Mage Meadowbrook, who shares Fluttershy's eye shape.The Stare was based on something Lauren Faust's mother used to do.[7]
Depiction in the series
HistoryThe episodes The Cutie Mark Chronicles and Hurricane Fluttershy offer glimpses into Fluttershy's past. Like Rainbow Dash, Fluttershy hails from Cloudsdale. As a filly, she was a weak flier and was harassed by the same Pegasi who were jeering at Rainbow Dash in Sonic Rainboom, and they nicknamed her "Klutzershy". She was taller and ganglier than most other foals, similarly to Plaid Stripes, "Pearly Whites", "Thunderstruck", later filly Pear Butter, later filly Applejack, later filly Derpy, and Crystal Hoof, and had slightly larger wings. Rainbow Dash flew in to defend her and challenged the bullies to a race. When the race started, the participants accidentally knocked Fluttershy off the clouds, and she plummeted toward the ground, a place she had never been to or seen before. She was saved from a rough landing by an incoming large swarm of butterflies.
Upon seeing the animals and the greenery for the first time, Fluttershy becomes overwhelmed by the beauty of it all and starts singing. A few moments later, Rainbow Dash's sonic rainboom startles the animals and scares them into hiding. Fluttershy earns her cutie mark after comforting the animals and realizing her ability to talk through to them, identifying her special connection with animals.
ShynessWhen Fluttershy is first introduced in the series, she barely manages to tell Twilight Sparkle her own name on account of her timidity, whispering so quietly that Twilight cannot hear her, and hiding her face behind her mane. However, she immediately becomes enthusiastic when she sees Spike, imploring the baby dragon to hold a conversation with her, which he ends up doing, and follows him and Twilight all the way to the library. Her shy nature contrasts with Rainbow Dash's abrasiveness, most notably in Dragonshy, and to a lesser extent in Sonic Rainboom. In season one, Fluttershy's inability to speak up often annoys Rainbow Dash, and Rainbow expresses her aggravation more than once. One instance is when Fluttershy cheers as loudly as she can for Rainbow Dash at the beginning of Sonic Rainboom, yet much to the latter's exasperation, can't manage more than a whisper. Season two shows them having grown closer to each other as friends despite their differences.
Fluttershy states in Dragonshy that dragons scare her, though she explains the exception of Spike on account of him not being grown-up. Because of this, she hesitates to continue forward when she and the others embark on an expedition to deal with a sleeping dragon in the aforementioned episode, relying heavily on her friends' encouragement. In the end, Fluttershy finds the courage to speak to the dragon when it begins harassing her friends, going so far as to raise her voice in anger and stand on its nose to look it in the eye as she lectures it. In Stare Master, she tames a wild cockatrice in a similar manner, becoming angry with it when it scares the Cutie Mark Crusaders; however, in this instance, the Stare is employed.
Gilda reduces Fluttershy to tears in Griffon the Brush Off when the griffon roars in her face. Afraid to be in the same room as Gilda during Pinkie Pie's party, Fluttershy attempts to voice her discomfort to Pinkie, who obliviously waves off her distress.In Luna Eclipsed, Fluttershy sequesters herself at home in her cottage during Nightmare Night, and refuses to answer the door until she learns that her visitor is Twilight. Twilight then forcibly brings Fluttershy out to give Princess Luna a lesson in how to speak softly, with the Princess's "Royal Canterlot Voice" terrifying her.
In Dragon Quest, she again displays her fear of dragons. Fluttershy pointedly refuses to watch the Dragon Migration with her friends, despite Twilight's coaxing. It culminates in Fluttershy pushing past Rainbow Dash and jumping out the window, fleeing the scene before any of them could follow her.In Hurricane Fluttershy, she tries to evade her responsibilities as a Pegasus to help create a tornado to move water to Cloudsdale from Ponyville's reservoir. After some insistence from Rainbow Dash, she reveals that she is afraid of humiliating herself by performing badly as a flyer in front of all the other Pegasi. She becomes even more discouraged after the anemometer (wing power gauging machine) gives her wing-power as only 0.5. Her animals' motivation causes her to engage in a period of training and exercise, but her second attempt only puts her at 2.3, further diminishing her hopes for improvement. In the end, Twilight convinces her to help when the other Pegasi's wingpower proves not to be enough to create the tornado. With a sudden burst of determination, she manages to surpass all the other Pegasi in flying speed, completing the 800 wingpower minimum to create the tornado and resulting in the water successfully reaching Cloudsdale.
In Castle Mane-ia she displays fear at the possibility of running into star spiders. In the episode Maud Pie, she tells Maud about spiders that live in Ponyville, saying that "even though they may look a teeny bit scary, they're actually very sweet and help keep other, more dangerous insects away!"
From season five onward, however, Fluttershy shows considerably less hesitation and timidness when taking action in dangerous situations.
Kindness and empathy
- "Fluttershy, who tamed the manticore with her compassion, represents the spirit of kindness."
- — Twilight Sparkle
In The Return of Harmony Part 1, she is the only pony who isn't easily affected by Discord's manipulation, prompting him to forcefully hypnotize her into her polar opposite (in her case, cruelty). In this state, she appears to take pleasure in causing others grief and distress, such as trampling the flowers in front of the library, dumping water on Twilight Sparkle and Spike and snatching the Elements of Harmony from Twilight. When Twilight Sparkle sets out to reverse Discord's effect on her friends using a "memory spell", Twilight and Applejack are forced to hogtie her and pin her to the floor, with Applejack standing on her tail to prevent her from flying away. Upon returning to normal, a horrified Fluttershy initially believes her corrupted state to be a horrible dream.In Keep Calm and Flutter On, she is the only one of the Mane Six who believes Discord can be redeemed. She shows him genuine kindness and friendship, eventually leading him to change his ways.
In Filli Vanilli, when she sings for Big McIntosh in the Pony Tones, she accepts request after request for the Pony Tones to sing so she doesn't disappoint anyone.
In It Ain't Easy Being Breezies, when she comes to care for a group of Breezies, Fluttershy learns to set aside her kindness and do what has to be done for the sake of everyone involved.
Despite her typically shy behavior, Fluttershy occasionally demonstrates more assertiveness and confidence. After Rainbow Dash's encouragement in Sonic Rainboom, she stands up to Hoops, "Dumb-Bell", and "Score" when they pick on her. In Putting Your Hoof Down, she learns to stand up for herself without resorting to anger. In Rainbow Falls, she eagerly represents Ponyville at the Games tryouts with Rainbow and Bulk Biceps.
In Tanks for the Memories, Fluttershy sternly tells Rainbow Dash that she has to spend her winter without Tank.
As of season six, Fluttershy has developed a somewhat witty, playful side to her assertiveness. In Flutter Brutter, she demonstrates constant, often snarky assertiveness toward her slacker younger brother Zephyr Breeze. In Dungeons & Discords, she cheekily encourages Discord to spend time with Spike and Big McIntosh. In Viva Las Pegasus, she teasingly urges Applejack to put aside her grudge with Flim and Flam to solve their friendship problem.
In Fluttershy Leans In, Fluttershy becomes assertive when her vision for her animal sanctuary is not met.
AngerFluttershy has also shown a more aggressive side on rare occasions. Most of the time, Fluttershy can withstand almost anything that will make other ponies explode in anger. However, even a shy Pegasus like Fluttershy has her own limits.
In The Best Night Ever, Fluttershy slowly becomes frustrated when the animals living in the Canterlot castle gardens avoid her. Instead of continuing her kind and calm ways to earn the animal's trust, she decides to make them love her by setting animal traps, hoping to trap them in a cage. Eventually, the shy Pegasus explodes, yelling and screaming, wanting the animals to love her.
Fluttershy becomes angry when reminded that Discord will win if she is not able to catch Rainbow Dash in The Return of Harmony Part 2 (referring to Discord as a "big dumb meanie"). This is one instance where Fluttershy doesn't explode in anger but expresses her anger in words.
In Putting Your Hoof Down, Fluttershy is too much of a "doormat", where a pony can easily take advantage of the situation to their own benefit. For example, if a pony purposely cuts Fluttershy, she apologizes, saying that the pony can go first. Pinkie Pie and Rarity say that Fluttershy should stand up for herself so that she isn't pushed around. After receiving motivational advice from Iron Will, a manly minotaur that helps ponies like Fluttershy, she becomes progressively more violent and aggressive, to the point of reducing Pinkie Pie and Rarity to tears with her insults. However, she changes her ways by the end of the episode.
Fluttershy gives Twilight a threatening warning if anything happens to her animal friends during a magic trick in Magic Duel. In Keep Calm and Flutter On, she angrily renounces her friendship with Discord when he abuses it.When all of the main cast gets sucked into Spike's comic book in Power Ponies, Fluttershy takes the role of Saddle Rager, who is part of a group of superheroes called the Power Ponies. Her power is based around anger, which didn't manifest until the climax of the episode, when she loses her temper after witnessing a firefly being smacked away by the Mane-iac, causing her to take the form of a huge muscular monster.
In It Ain't Easy Being Breezies, she becomes angry at the bees for trying to hurt Seabreeze after her attempts at kindness don't work on them.In Dungeons & Discords, when Discord turns the world "opposite", Fluttershy becomes affected, yelling at Discord, calling him "Sassafras", and saying that she's "sick of being nice and quiet all the time!" Discord immediately changes the world back, and Fluttershy blushes with embarrassment.
In Buckball Season, Fluttershy gets angry at Applejack and Rainbow Dash for putting so much pressure on her and Pinkie Pie for the upcoming Buckball game against Appleloosa.
Despite being a Pegasus, Fluttershy does not usually help with the weather and does not use her wings as much as the other winged ponies. As shown in Dragonshy, she is also scared of heights, which is ironic in that Pegasi live in the clouds most of their lives. Because of this, she instead focuses on tending to animals' care. In Party of One, Spike says, "Fluttershy [is] a Pegasus who's afraid of heights. Heh, what's up with that?"
Animal careFluttershy's special talent is communicating with animals, which she uses in order to provide them with food, medical attention and other forms of care when they need it. In addition, a host of animals have taken up residence in her home, which she attends to and looks after on an everyday basis. In Dragonshy, she delivers fish to a family of otters and gives worms to a family of birds to eat. In A Bird in the Hoof, she had just finished treating a mouse's broken leg before Angel reminded her of the luncheon for Princess Celestia, at which she discovers Celestia's "sick" bird, Philomena. Without the Princess's knowledge or permission, she takes the bird back to her cottage to try to recuperate it. However, her abilities prove to be ineffective in "healing" her; it is later revealed that Philomena is a phoenix and was simply nearing the end of her life cycle. In Lesson Zero, she appears to violently attack and injure a bear but is actually giving it a rigorous massage to ease the tension in one of its shoulders. In Keep Calm and Flutter On, Applejack puts Fluttershy's communication talent to use when she summons Fluttershy to negotiate the removal of a dam with a family of beavers, who had caused flooding at Sweet Apple Acres by blocking a stream with said dam.
She comes across a new species in Bats! - vampire fruit bats - and admits that it might take her a while to learn their language. After failing to persuade her friends that they aren't monsters, she suggests the possibility of giving the bats an area of the orchard as a sanctuary, which at the end of the episode becomes a reality.
In the episode It Ain't Easy Being Breezies, Fluttershy knows much about Breezies, such as their migratory patterns and native language (she speaks several words of it near the end of the episode). When a group of Breezies find themselves in Fluttershy's care, they form an attachment to her and don't want to leave her side.
The Stare"The Stare" is the name given to a particular ability Fluttershy employs when dealing with misbehaving animals. This ability is powerful as it can 'control' chickens up to her own pet bunny, Angel. However, Fluttershy doesn't really like to use the Stare. Only when someone's life is in danger or to maintain order, the Stare is used.
Rarity is the first to use this name in Stare Master, while asking Fluttershy if she had used it on Opal to get her to behave during the cat's grooming session, to which Fluttershy replies that she had not.
Fluttershy first uses the Stare in Stare Master, employing it on her chickens to herd them back into the henhouse. When the Cutie Mark Crusaders notice that one of the chickens, Elizabeak, has escaped into the Everfree Forest, they disobey Fluttershy's orders to stay put and run off into the forest to search for the bird. When Fluttershy goes looking for the Crusaders, she comes across Twilight Sparkle petrified (turned to stone by a cockatrice) in the forest. She finds the Crusaders, but while she is trying to warn them of the danger they are in from the cockatrice, they are all ambushed by one. It petrifies Elizabeak, then turns to Fluttershy and the Crusaders. Fluttershy, seeing the three fillies cowering behind her, becomes angry at it. She lectures the cockatrice, but when it won't back down, uses the Stare on it, ignoring the fact that as she must look it in the eye to do so, she is being turned to stone. The cockatrice finally relents (causing her own petrification to be reversed), and unpetrifies both Twilight Sparkle and Elizabeak at her command. She again uses the Stare at the end of Putting Your Hoof Down on Angel to make him eat his carrot salad. In Keep Calm and Flutter On, Fluttershy attempts to use the Stare on the newly freed Discord to make him behave. It proves to be ineffective against him, though he briefly feigns being affected by it to mock her, even pretending to strangle himself.
Her friends call upon her to use her Stare in Bats!, in order to keep the attention of the vampire fruit bats long enough for Twilight to alter their behavior with a spell. Fluttershy states that the Stare isn't "something [she takes] lightly", saying that she's taken a vow not to use it except in dire emergencies. Prior to using the Stare itself, she tells the bats that she hopes they can forgive her for doing so.
Fluttershy uses the Stare on a changeling in chapter 14 of Lyra and Bon Bon and the Mares from S.M.I.L.E., "The Saddle Hawkins Square Dance".
In A Health of Information, a sickened Fluttershy attempts to use the Stare on a swarm of flash bees, but it is unsuccessful.
FlightFluttershy is an average flier under normal circumstances but is incapable of flight in moments of fear or stress. In Dragonshy, hearing the dragon's snore at the bottom of the mountain renders her paralyzed in midair. Fluttershy later fails to cross a chasm using her wings even after her anxiety had faded slightly. In the end, she casts aside her fear as she flies to her friends' rescue after Rainbow Dash launched a reckless assault that angered the dragon. In Feeling Pinkie Keen, she does not fly in order to escape the hydra, though she flaps her wings while running and jumping. In Putting Your Hoof Down, she doesn't fly above Sweetie Drops and Cherry Berry's wagons, and instead demands for them to get out of the way. In the episode Wonderbolts Academy, after the Twinkling Balloon that she and her friends are traveling in is destroyed, she does not remember that she can to fly to safety until Cloud Chaser rescues her. Fluttershy sheepishly pulls herself out of her rescuer's grasp and hovers in mid-air, to Cloud Chaser's annoyance.
Fluttershy appears to possess only average physical strength at best, as she barely carries Twilight Sparkle a short distance in Friendship is Magic, part 2, even with Rainbow Dash's help. In the episode, she admits to not being used to holding more than a bunny or two. She also attempts to carry Rainbow Dash to her cottage in May the Best Pet Win! after Rainbow Dash asks for a pet, but when she fails to lift her friend off the ground, Rainbow uses her own wings to propel both of them further up.Despite her shortcomings at flying, Fluttershy has still performed some remarkable flying feats. She whizzes past Rainbow Dash in The Mysterious Mare Do Well while dressed in a Mare Do Well costume, catching her by surprise. She also catches up to a weighed down Rainbow Dash while pulling two ponies and the Twinkling Balloon in The Return of Harmony Part 2. In Hurricane Fluttershy, her "wing power" initially measures at 0.5 (her fellow Pegasi measuring above 5 initially), with an exhaustive training session raising it to a mere 2.3. However, when flying with her fellow Pegasi, she exerts herself enough to help them achieve the missing 5 wing power necessary to create the hurricane that would carry the water to Cloudsdale. Rainbow Dash reminds her of what Rainbow considered to be a "wicked" nose dive to save a baby bird. Earlier in the episode, she had a flashback from when she and Rainbow Dash were in Summer Flight Camp as fillies. Her fear of heights led to her pitfalls as a Pegasus, which led to the other Pegasus foals teasing her and chorusing the chant: "Fluttershy, Fluttershy, Fluttershy can hardly fly!" which changes at the end of the episode to: "Fluttershy! Fluttershy! Fluttershy can really fly!" by the other Pegasi after they succeeded in bringing water up to Cloudsdale with her involvement in the task.
While she usually gets around by walking or running, Fluttershy tends to hover and fly when she is very happy, or in high spirits. Additionally, she also will gracefully twirl and do small flips if she sings at the same time. When singing about meeting the animals as a filly in The Cutie Mark Chronicles, and speaking about her wish to see the animals in the private castle gardens during the Grand Galloping Gala in The Ticket Master, she goes airborne without seeming to notice that she did so. Helping Rainbow Dash chose a pet of her own also causes her to fly in her excitement, and when she and the others were invited to take part in Shining Armor and Princess Cadance's wedding in A Canterlot Wedding - Part 1, she flies around in the air with Rainbow as they encircle each other. She also pursues Angel in Dragonshy and the Cutie Mark Crusaders in Stare Master in this manner.
SewingShe is familiar with sewing, a skill Applejack describes as "freaky" in Suited For Success. She helps to finish the dress Rarity had designed for herself with her friends in this episode. She dislikes a revised dress Rarity made her at first. When pressed to explain what she doesn't like, she points out uneven pleats, machine stitching, etc.
MusicWhen Fluttershy is first introduced in Friendship is Magic, part 1, she conducts a rehearsal for a choir of birds for the Summer Sun Celebration. She has several musical numbers in the show: her rendition of the Evil Enchantress song, the Hush Now Lullaby, So Many Wonders, Find A Pet Song which is a duet with Rainbow Dash, Music in the Treetops, and Find the Music in You with the Pony Tones. She idly hums the theme to the show in The Ticket Master and A Bird in the Hoof. Princess Celestia also asks Fluttershy and her songbird choir to provide the music for the wedding in A Canterlot Wedding - Part 1. In Filli Vanilli, she sings for her animal friends during Music in the Treetops and, as Flutterguy from the public eye, in Big McIntosh's place as the "fourth member" of the Pony Tones. She later becomes the group's part-time fifth member.
- See also: #Flutterguy
Notable identities
FlutterguyIn the episode Bridle Gossip, Fluttershy, as well as her friends, is affected by poison joke while chasing Zecora through the Everfree Forest, giving her a deep, masculine voice. While at first reluctant to even talk due to the embarrassment of her situation, Pinkie Pie finally brings out Fluttershy to sing the Evil Enchantress song. After that, she and her friends are cured by Zecora by taking an herbal bubble bath. In Filli Vanilli, her secret love of singing and dedication to the Pony Tones quartet push her to consume a solution of poison joke prepared by Zecora to replace the temporarily voiceless Big McIntosh from behind the curtain. However, after a few performances, she gets too into her new role and blows her own cover in public; the reaction overwhelms Fluttershy and pushes her into hiding, and she takes an herbal bath to return her voice to normal. She ultimately accepts becoming a part of the Pony Tones quintet as herself, only agreeing to take "baby steps" toward larger audiences.
FlutterbatIn Bats!, Twilight accidentally transfers the vampire fruit bats desires into Fluttershy, causing her to transform into a vampire fruit bat-pony hybrid. When Rarity sees her, she dubs her "Flutterbat". She gains fangs, bat wings, red eyes and bat-like ears, and her cutie mark changes into three pink bats. Flutterbat easily outmaneuvers the rest of her friends in the air, while at the same time sucking the juice out of apples and spitting out their seeds. In one instance, she wraps her tail around a tree branch to maneuver. Twilight eventually manages to restore her back to normal. However, at the end of the episode, Fluttershy retains a small fang.
In Do Princesses Dream of Magic Sheep?, Fluttershy once again takes the form of Flutterbat in Ponyville's shared dream to help Princess Luna defeat the Tantabus. She also wears a Flutterbat costume in an attempt to scare her friends on Scare Master.
PetsLike any animal lover, Fluttershy has several animals that live with her or near her, though she never considers any of them as her "pets." Prominent among Fluttershy's pets is her bunny Angel. Introduced in The Ticket Master, Angel has a bold and forceful personality in contrast to Fluttershy's soft-spoken and shy nature, often trying to motivate her to speak her mind and not let certain things dampen her spirits. Examples of this include A Bird in the Hoof, where he locks her out of the cottage to stop her from stalling by constantly returning to thank him, and The Ticket Master, where he insists on Fluttershy being more proactive in pursuing the extra ticket to the Grand Galloping Gala. However, in Putting Your Hoof Down, Angel acts stubborn and temperamental when he refuses to eat a carrot salad she prepared for him and wants a more complicated recipe which Fluttershy refers to as his "special recipe."
In addition to Angel, Fluttershy appears to have several more animals that she pals around with more often than not. Among these are a hummingbird named Hummingway, an orange bird named Constance, a pair of otters, a chicken named Elizabeak, a mouse called Mr Mousey, a spider named Fuzzy Legs, and a bear named Harry. In the chapter book Twilight Sparkle and the Crystal Heart Spell, it's stated that she's gotten a new fruit bat called Toby.
There are far more animals that accompany her at random times, such as squirrels, mice, and bats, but most of these have not been given names yet.
ResidenceFluttershy lives in a cottage at the edge of the Everfree Forest and on the outskirts of Ponyville. It appears in several episodes throughout the series. The cottage's roof is covered in grass and bushes and is filled with runways, holes and perches for animals such as birds, mice, etc.
In Stare Master, Fluttershy's chicken coop in her cottage's backyard appears for the first time. In May the Best Pet Win!, Fluttershy is delighted to hear that Rainbow Dash wants a pet and takes her to the backyard, where she presents her friend with a great variety of animals to choose from.
Fluttershy's cottage is named "Fluttershy's Cabin" in Gameloft's mobile game.
Depiction in films
- Main article: Fluttershy (EG)
My Little Pony Equestria GirlsIn My Little Pony Equestria Girls, Fluttershy accompanies Twilight to her first princess summit in the Crystal Empire, and she witnesses Sunset Shimmer steal Twilight's crown. In an alternate world, Fluttershy's human counterpart appears as a high school student.
My Little Pony Equestria Girls: Rainbow Rocks
Fluttershy briefly appears in the sequel My Little Pony Equestria Girls: Rainbow Rocks at Twilight's castle, where she hears the legend of the sirens.
Depiction in comics
In Issue #2 of the IDW comic, The Return of Queen Chrysalis, Fluttershy shows an interest in spiders, and disappointment that "Fluffy" the giant tarantula turned out to be mean, saying that most spiders are docile.
In My Little Pony Micro-Series Issue #4, she has a "Chamber of Extreme Knitting" in her basement, a studio full of knitted designs.
In Night of the Living Apples, she becomes Flutterbat once again in order to stop Bad Apple and the other living apples from taking over Equestria.
In Ponies of Dark Water, Fluttershy turns evil after being exposed to a mysterious hot spring. She becomes overprotective of her animal friends and the forest, perceiving any who intrude upon them as a threat.
In My Little Pony Annual 2017, an illusion of an injured Fluttershy appears as part of a magical test undergone by Shining Armor; upon his refusal to leave her, she is replaced by a magical recording of Princess Amore who congratulates Shining Armor on his compassion.
Other depictions
Fluttershy is voiced by Brittany Lauda in PlayDate Digital's apps Fluttershy's Famous Stare[1] and Power Ponies.[2]
Hasbro.com description
A graceful, fawn-like filly, Fluttershy's gentle, serene ways makes her unusually attractive to all types of forest animals, whose care and well-being are her highest priority. She'd like nothing more than to spend every waking moment caring for her animal friends in her secluded meadow cottage, and that's because Fluttershy is, well... shy. Sweet, soft-spoken, and often fearful, her pony friends treasure her kindness, but have to work hard to help her come out of her shell. To their surprise, however, she emits an intimidating strength when she witnesses someone else being treated unfairly. Fluttershy has a lot of fears to overcome, but certainly one day her strength of character and enormous heart will make her a force to be reckoned with![8]
Hasbro.com second description
It's widely known that Fluttershy is kind to every creature in Equestria, no matter how big or small. Though she's the soft-spoken member of the group, Fluttershy is a great cheerleader. Sweet and caring, she makes plenty of space in her tucked-away cottage for helping anyone in need of her love and care, especially her little animal friends. But don't be fooled! When push comes to shove, she'll always stand up for her friends![9]
HubNetwork.com description
Graceful Fluttershy has a special way with forest animals. Her favorite thing is to care for them in her quiet meadow cottage. That's because Fluttershy is, well ... shy. She's sweet, soft-spoken, and kind of a scaredy-pony. Her friends love her for her kindness, and they work hard to bring her out of her shell.
Teacher for a Day description
A friend to the forest, Fluttershy is the gentle, soft-spoken member of the group. Sweet and caring, she makes plenty of space in her tucked-away cottage for helping anyone in need of her love and care, especially her little animal friends.
But don't be fooled! Although she is timid, she is a determined pony with admirable strength. She always defends those who are treated unfairly. With an enormous heart and the ability to fly, this Pegasus pony is a gentle soul who always rises to the occasion and is always there when her friends need her![10]
My Little Pony mobile game description
Representing the Element of Kindness, Fluttershy is a shy pony who loves to sing with her animal friends.
In the Signature My Little Pony magazine issue 69 comic Daring friends and the missing story!, Fluttershy appears at her cottage.[11]
My Little Pony magazine description
- Graceful
- Musical
- Gentle
She's rather shy and loves to sing with animal friends. Fluttershy is generous and sweet, sometimes a little too trusting and always eager to help.
The Elements of Harmony guidebook
FLUTTERSHY is a natural beauty with her gentle, serene ways. Despite her shy and unassuming nature, Fluttershy has a unique gift with animals. Her sweetness and sincerity can charm every animal, from tiny woodland creatures to the most powerful of mythical beasts, making her a valuable asset to her friends in all their adventures. Although she's afraid of heights (very embarrassing for a Pegasus) and shies away at the slightest sound, Fluttershy has no problem confronting grumpy manticores or scolding greedy dragons. While she lacks confidence, she has an inner strength that comes out when others are in trouble. Fluttershy has a lot of fears to overcome, but one day her strength of character and enormous heart will make her a force to be reckoned with.
Volume II guidebook
When her pony pals are down in the dumps, Fluttershy swoops in to cheer them up in her own sweet and quiet way. She delights in the beauty of friendship and the nice feelings that come from being nice. Fluttershy is definitely a little bit meek, but she can be fierce when she needs to be. She's faced her fears and grown a whole bunch, and she continues to build her self-confidence! Oh, and she loves her animals. A LOT! Even when they're being naughty little critters. She's probably the most in tune with creatures of the forest of all the ponies she calls her friends.
The Art of My Little Pony The Movie description
FLUTTERSHY is gentle and kind. Her sweetness and sincerity can charm any animal, from tiny woodland creatures to the most powerful, menacing storm creatures, making her an asset to her friends on all their adventures. Although she sometimes lacks confidence in herself, she has an inner strength that comes out when others are in trouble.
Fluttershy represents the Element of Kindness!
On the back of the Canterlot toy set Royal Ball at Canterlot Castle, Fluttershy is printed wingless.This happens often on merchandise when she is rearing on her hind legs, as her hair obscures her wings. Sometimes only the tips of her wings can be seen.
On the back of the Crystal Empire variant of Design-A-Pony Fluttershy toy packaging, Fluttershy's name appears as "FLUTTERSHYy"[sic],[12] with a registered trademark symbol in the monolingual version.[13]
On at least[specify] the DVD Season Four Disc 3, closed captions for the episode It Ain't Easy Being Breezies refer to Fluttershy as Shutterfly, a name used for her by Discord in the episode Princess Twilight Sparkle - Part 1.
- See also: Character appearances
|At least one appearance where the character is the focus of a shot
|At least one appearance where the character is the focus of a shot, without spoken dialogue or narration
|Background appearance or an appearance where the character is not the focus
|No appearance, but a mention by name or title
|No appearance and no mention by name or title
- "Um, excuse me, sir. I mean no offense, but your rhythm is just a teeny tiny bit off."
- — Friendship is Magic, part 1
- "A baby dragon! Oh, I've never seen a baby dragon before. He's so cute."
- — Friendship is Magic, part 1
- "Oh no, I'm doing this because you're my very best friend. Right Angel? Oh, yes, we are just doing this for the ticket."
- — The Ticket Master
- "I'm a year older than you."
- — To Pinkie Pie, Griffon the Brush Off
- "How dare you? How dare you! Listen here, mister. Just because you're big doesn't mean you get to be a bully. You may have huge teeth, and sharp scales, and snore smoke, and breathe fire. But you do not—I repeat—You do not! Hurt! My! Friends! You got that?"
- — Dragonshy
- "[inhales] Yay."
- — Sonic Rainboom
- "Oh no! I wouldn't. I couldn't. I-I don't really have any control when it happens. It just happens. Really. I'm just good with animals. It's my special gift, you know."
- — Stare Master
- "Now that we've gotten that out of the way, how about a game?"
- — Stare Master
- "Oh, Fluttershy. You're such a loudmouth."
- — The Best Night Ever
- "I'll catch you yet, my pretties. Oh yes, as soon as one of you little birds or monkeys or bears touches this net, you'll be mine! MINE! HahahaHAHAHA! "
- — The Best Night Ever
- "You're... going to LOVE ME!'"
- — The Best Night Ever
- "Hey Twilight, what's soaking wet and clueless? [...] Your face!"
- — The Return of Harmony Part 2
- "That... big... dumb... meanie!"
- — Referring to Discord, The Return of Harmony Part 2
- "Nopony pushes new Fluttershy around! Nopony!'"
- — Putting Your Hoof Down
- "I can't believe that the two most frivolous ponies in Ponyville are trying to tell new Fluttershy how to live her life, when they are throwing their own lives away on pointless pursuits that nopony else gives a flying feather about!"
- — Putting Your Hoof Down
- "I'm the monster."
- — Putting Your Hoof Down
- "There is nothing fun about dragons. Scary: yes. Fun: NO!"
- — Dragon Quest
- "I will get my confidence up and show everypony that I am a good flyer! A great flyer!"
- — Hurricane Fluttershy
- "Dear Princess Celestia, sometimes you can feel like what you have to offer is too little to make a difference, but today, I learned that everypony's contribution is important, no matter how small. If you just keep your head high, do your best, and believe in yourself, anything can happen!"
- — Hurricane Fluttershy
- "[gasp] Th-That's one of the things, isn't it?"
- — The Crystal Empire - Part 1
- "We knew for sure you would prevail."
- — During The Success Song, The Crystal Empire - Part 2
- "[gasp] Mr. Beaverton Beaverteeth! Such language!"
- — Keep Calm and Flutter On
- "He can be a real sweetheart once you get to know him."
- — Referring to Discord, Keep Calm and Flutter On
- — Castle Mane-ia
- "Mmm, it's so nice to be the pet for once."
- — Do Princesses Dream of Magic Sheep?
- "I don't know why I doubted myself for a second. Now this is what I call a perfect Nightmare Night."
- — Scare Master
- "Um, if you could not maybe yell so much, or maybe stop saying words all together."
- — The Hooffields and McColts
- "And I was worried that I'd fail every time! Sometimes you have to do things, even though you might fail."
- — To Zephyr Breeze, Flutter Brutter
- "Well, guess what, Sassafras?! I'm Opposite Fluttershy, and I'm sick of being nice and quiet all the time!"
- — To Opposite Discord, Dungeons & Discords
- "My dream is to build a real animal sanctuary. A beautiful habitat where every animal – whether sick or scared or even just lonely, feathered or furry, scaly or slimy – every critter would be welcome. My sanctuary can be the one place in Equestria they call home 'til they feel ready to take on the world."
- — Fluttershy Leans In
See also
- Toys and merchandise
- Fluttershy (EG)
- Fluttershy on the Collectible Card Game Wiki
- Fluttershy on the Fan Wiki
- Fluttershy on the My Little Pony Gameloft Wiki
- This article's speculation page.
- ↑ 1.0 1.1 Brittany Lauda (2014-04-24). Brittany's Voice Roles - Brittany Lauda - Voice Actress. Facebook. Retrieved on 2014 July 18.
- ↑ 2.0 2.1 Brittany Lauda (2014-07-17). Brittany's Voice Roles - Brittany Lauda - Voice Actress. Facebook. Retrieved on 2014 July 18.
- ↑ 追加キャストは沢城みゆきと加藤英美里 TVアニメ『マイリトルポニー ~トモダチは魔法~』4月2日より放送開始 (Japanese). オタラボ (2013-03-18). Retrieved on 2013 March 18.
- ↑ Jayson Thiessen at the 2012 New York Comic Con My Little Pony panel (2012-10-11). Retrieved on 2012 October 12.
- ↑ Lauren Faust (2013-11-29). Posey inspired Fluttershy. I did that tail-do when I was 8!. Twitter. Retrieved on 2013 December 2.
- ↑ Lauren Faust, Mary Jane Begin (2015-10-13). My Little Pony The Art of Equestria. Abrams Books. Retrieved on 2015 October 15.
- ↑ Lauren Faust (2011-08-30). Comment on The Stare by fyre-flye. DeviantArt. Retrieved on 2015 December 4.
- ↑ Meet The Ponies: Fluttershy. Hasbro.com. Retrieved on 2013 September 8.
- ↑ My Little Pony - Meet Fluttershy. Hasbro.com. Retrieved on 2013 September 8.
- ↑ Movie Clip Meet Fluttershy Video. Hasbro.com. Retrieved on 2013 September 8.
- ↑ MLP Comic - English. Imgur (2017-03-23). Retrieved on 2017 May 27.
- ↑ d384c5dabd9ffd1f9972baba58ea83d8_zpsb3949330.jpg (2013-05-27). Retrieved on 2013 June 9.
- ↑ design a pony fluttershy review part 1 (2013-04-23). Retrieved on 2013 June 9.


text:
'Strong' 30-Yr TIPS Auction Despite Low Inflation
Inflation has been pretty much a no-show this year, and that's been bad news for investors in Treasury inflation-protected securities, or TIPS. These bonds combine the safety of Treasuries with a safeguard against inflation in the form of a principal value that rises and falls along with a benchmark inflation index. They're supposed to be among the safest, most conservative investments around, but instead have been one of this year's worst performers after getting hit by the summer bond selloff.
Supporters of TIPS frequently make insurance analogies, saying the best time to buy flood insurance is in the dry season when that insurance is cheapest, and similarly that now is the time to be buying TIPS after the market tanked earlier this year and with inflation still running below 2%, but with the Fed now looking like it won't be slowing its stimulus measures anytime soon. It looks like some investors were buying that sales pitch Thursday, as the Treasury sold $7 billion of 30-year TIPS in what Ian Lyngen of CRT Capital called a "strong" auction that yielded 1.33%.
Here's Tom DiGaloma of ED&F Man Capital with his take:
TIPS are back in demand with the 30yr auction coming in 2 bps richer than the 1pm level. Indirect bidders received 45% of the auction while Directs took 19%. The last two auctions tailed two basis points. Demand for TIPS has been increasing in the last few weeks as investors are anticipatining for inflation to take off once again.
The iShares Barclays TIPS Bond Fund (TIP) is up 1 cents early Thursday afternoon to $113.13, still down 7.3% over the past six months.
Declaring War: Dow Drops 53 Points, Falls For Third Day as Tech Tanks
Gene Therapy Is Nearing a Major Breakthrough
Transocean: 3 Reasons to Buy?
3 Alibaba Headlines: AliPay Hits Canada; More Markets For Taobao; Taking a Page From Ikea
Hewlett Packard: Mob of Four Activists Circling $7B in Cash, Says RBC

subset: commoncrawl


text:
La Mer brings you the sleekest watches around. In a world where technology puts everything right at the tips of your fingers, the only thing your wrist needs is a watch. For centuries, watches have been an essential accessory, the small piece that brings together an outfit, and La Mer is in the school that thinks less is more. That's why each watch is personally hand-crafted in the United States, and brings an intimate appeal that could only come from something crafted by an artisan.
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text:
Most Employers Plan to Continue Offering Health Care Plans
An overwhelming majority of midsized and large companies plan to continue offering employees health care plans, rather than pay the high price of penalties and other financial costs.
Considering the combined price of tough penalties and other financial costs to do away with health care plans, an overwhelming majority of employers say they plan to keep offering health benefits, according to a new survey.
The study, released Feb. 28 by Lincolnshire, Illinois-based HR consultancy Aon Hewitt, found that only 6 percent of large and midsized companies intended to terminate their health plans within the next three to five years.
Starting in 2014, the Patient Protection and Affordable Care Act will require employers with at least 50 employees to offer health insurance plans. Those that don't will be liable to pay a non-tax-deductible penalty of $2,000 for each employee. And to remain competitive, many employers not offering health benefits would likely have to start increasing their employees' salaries in order to offset the price they would have to pay to purchase their own coverage, according to the survey.
Many employers are considering implementing design changes to their health benefits and the way they're offered, the survey shows.
During the next three to five years, 37 percent of employers plan to offer what Aon Hewitt has labeled a "house money/house rules approach," which means employers may offer reduced premiums to employees who take health risk questionnaires or biometric screenings. Others may offer to pay employee prescription copayments for those who demonstrate they're following doctor's orders on chronic health conditions, according to Aon Hewitt.
Additionally, during the next three to five years, 28 percent of employers expect to move to private health insurance exchanges. Under this approach, employees would receive credit to purchase coverage through a private insurer.
Some employers have already started offering employees and retirees insurance through private exchanges. Last year, Aon Hewitt launched an exchange in which 100,000 employees from varying companies participate.
Max Mihelich is Workforce's editorial intern. Follow Mihelich on Twitter at @workforcemax. Comment below or email email@example.com.


text:
Brian Gay won on Sunday for the first time since 2009.
LA QUINTA, Calif. — Brian Gay found the extra distance he was looking for without sacrificing control.
That was clear late Sunday afternoon in the Humana Challenge when Gay, a Florida alum, cracked a 300-yard drive down the center of the fairway to set up a birdie on the first playoff hole.
A few minutes later, he split the fairway with a 297-yarder and made another birdie to hold off Charles Howell III for his fourth PGA Tour title.
"I'm still in a little bit of shock," Gay said. "It kind of happened so fast there at the end the way things went down. Last year was a struggle. It was a long year, a lot of work. I just wanted to come out this year kind of refocused, recharged, and believing in myself."
Gay won on the par-4 10th, putting his 9-iron second shot 5 1/2 feet below the hole. Howell drove into the right rough, hit into the back bunker, blasted out to 15 feet and two-putted for bogey.
The 41-year-old Gay, hardly an imposing figure at 5-foot-10 and 165 pounds, worked hard last year with Grant Waite and Joe Mayo to increase his driving distance.
"My whole game's been about accuracy and short game," Gay said. "I've always been a short hitter on the tour and I felt like as I was getting older I'm only going to get shorter and shorter. ... It was tough last year trying to play making those changes."
Gay closed with a 9-under 63 on PGA West's Arnold Palmer Private Course to match Howell and Swedish rookie David Lingmerth at 25-under 263. Howell shot a 64, and Lingmerth had a 62.
Lingmerth dropped out with a bogey on the first extra hole — the par-5 18th — after hitting his approach into the left-side water.
Scott Stallings, five strokes ahead entering the round, bogeyed the final hole for a 70 to miss the playoff by a stroke. Gay began the round six strokes behind Stallings.
"The thoughts were, 'Just be aggressive, shoot as low as you can,'" Gay said.
Howell tied for second a week after opening the season with a third-place tie in Hawaii in the Sony Open. He won the last of his two tour titles in 2007.
"Anybody that says that that golf is fun or whatever, has really not done it for a living," Howell said. "I would never characterize this as fun. It's different than that. It's awfully challenging mentally."
After birdieing nine of the first 13 holes, Gay finished regulation with five straight pars. On the 18th, he hit into the right greenside rough, chipped past the hole and missed an 8-foot birdie try.
"I felt like I gave one back with a par on 18," Gay said. "I was happy to be in the playoff."
Given a second chance, he outlasted Howell for his first victory since the 2009 St. Jude Classic. He also won the 2008 Mayakoba Golf Classic and 2009 Verizon Heritage.
Gay was a two-time All-American and three-time All-SEC honoree in his career at UF. He also was the SEC Individual Champion in 1992 and 1994 and a member of the 1993 National Championship team.


text:
by Josh Hathaway
I don't have a lot of trouble deciding what to listen to most days. I constantly have a song or song fragment in my head and I'm usually behind on music reviews, so I often have a starting place when my day begins and I follow it all to its logical conclusion.
It's not like that every day and that's when Encyclopedia Nerdicus is overwhelmed by the more than 30,000 songs on his iPod and the desire to acquire at least that many more. Where do you begin? Where do you start when you want to listen to everything and can only listen to one song at a time?
When that happens, I take my hand off the wheel and punch the accelerator. I buy the ticket, take the ride, m and speed all the way to the scene of the crash by letting my iPod go on autopilot.
Where did the day take me? Here is the playlist for this MusicMonday. It's presented in the order my iPod served the songs up to me. I didn't skip anything nor have I omitted anything for the sake of protecting my Encyclopedia Nerdicus image. I endorse all of these songs, some more than others. I'll highlight a few of them.
You can't go wrong starting with "Your Blue Room." That's still one of the best songs casual U2 fans and the public at large doesn't know. This is ambient brilliance at its best with Bono singing unbelievably well in both his upper and lower register. Some U2 fans don't consider the Passengers album part of the U2 ouvere and there's a reasonable debate to be had about that. For me, it's one of the best songs of their career- Top 10, easily.
Copyright 2012 U2 France / http://www.u2france.com/actu


text:
"Yo, next time you are going to be up in my area we should plan a couple hours ahead and get a match in. Same if I ever make it down your way."
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text:
ANTIOCH — A 9-year-old Oakley boy was critically injured Saturday after colliding with a 15-year-old boy as the pair rode their dirt bikes on an Antioch dirt lot, police said.
Despite both boys wearing appropriate protective gear and helmets, the younger boy had major head trauma and was flown to Children's Hospital in Oakland, according to Antioch police Sgt. Robert Quintero.
The boys were riding on separate off-road motorcycles around 1:46 p.m. Saturday in a dirt field at the end of Drive In Way in Antioch with adults on scene providing supervision, Quintero said. After the collision, the Antioch teen only had a complaint of pain, but a parent rushed the seriously injured younger boy to Sutter Delta Medical Center where he was stabilized before being flown to Oakland, police said.
Police are not naming the boys because of their age.
The collision is under investigation, Quintero said.
Anyone with information can call Antioch police at 925-778-2441. Anonymous tips can be texted to 274637 (CRIMES), using the key word "ANTIOCH."
Contact Matthias Gafni at 925-952-5026 or email@example.com. Follow him at Twitter.com/mgafni.


text: Pokemon affected by Leaf Stone Pokemon affected by Leaf Stone Retrieved from "http://roblox-pokemon-brickbronze.wikia.com/wiki/Leaf_Stone?oldid=46141" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected. Categories: Evolution items Info Items Add category Cancel Save


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A Phase I Concentration-Controlled Trial to Assess the Safety, Tolerance, Pharmacokinetics and Development of Decreased HIV-1 Susceptibility to the Combination of Atevirdine Mesylate (U-87201E), Zidovudine (AZT), and Didanosine (ddI)
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Part I: To determine the pharmacokinetic dose for atevirdine mesylate ( U-87201E ) when used in combination with zidovudine ( AZT ). To determine the pharmacokinetic profiles of U-87201E and AZT over a 12-week period.
Part II: To determine whether or not decreased viral susceptibility to U-87201E develops when the drug is administered concomitantly with AZT for 12 weeks.
Part III: To evaluate the pharmacokinetic effects of ddI/AZT/U-87201E therapy and to assess changes in viral susceptibility to U-87201E.
Interest exists in the development of antiretroviral agents that possess different mechanisms of action from nucleoside analogs such as AZT. U-87201E is a non-nucleoside reverse transcriptase (RT) inhibitor that has demonstrated activity against HIV-1; however, an emerging characteristic of non-nucleoside RT inhibitors is the development of rapid resistance to HIV isolates. Whether this resistance can be prevented in the presence of nucleoside analogs such as AZT and ddI has yet to be determined.
|HIV Infections
|Drug: Atevirdine mesylate Drug: Zidovudine Drug: Didanosine
|Phase 1
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|A Phase I Concentration-Controlled Trial to Assess the Safety, Tolerance, Pharmacokinetics and Development of Decreased HIV-1 Susceptibility to the Combination of Atevirdine Mesylate (U-87201E), Zidovudine (AZT), and Didanosine (ddI)
|Estimated Enrollment:
|Study Completion Date:
|October 1993
Interest exists in the development of antiretroviral agents that possess different mechanisms of action from nucleoside analogs such as AZT. U-87201E is a non-nucleoside reverse transcriptase (RT) inhibitor that has demonstrated activity against HIV-1; however, an emerging characteristic of non-nucleoside RT inhibitors is the development of rapid resistance to HIV isolates. Whether this resistance can be prevented in the presence of nucleoside analogs such as AZT and ddI has yet to be determined.
Part I: Five male patients enter a pharmacokinetic concentration-controlled trial of U-87201E plus zidovudine at the University of Rochester site only. A target plasma concentration range at trough for U-87201E will be determined. Pharmacokinetic monitoring continues for 7 days or until the desired dose regimen has been determined. The five patients may be eligible to continue in Part II of the study to complete a total of 12 weeks of therapy.
Part II: At least 10 male patients (all sites eligible) in addition to the five patients from Part I receive doses of U-87201E as determined by Part I and AZT at the same dose as in Part I. Therapy is administered for 12 weeks. Patients with no decreased viral susceptibility to U-87201E after 6 weeks may be offered an extension to 24 or more weeks of therapy. Patients are followed weekly for 8 weeks and every other week thereafter until the end of the study.
Part III: At least eight patients who have received 24 weeks of U-87201E/AZT have ddI added to the regimen for 12 additional weeks.
|Ages Eligible for Study:
|13 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Concurrent Medication:
- PCP prophylaxis with aerosolized pentamidine, trimethoprim / sulfamethoxazole or dapsone.
- Clotrimazole troches or nystatin oral suspension for oral candidiasis.
- Acyclovir (up to 1000 mg/day) for herpes lesions.
Patients must have:
- HIV infection documented by serologic tests or HIV culture OR prior diagnosis of AIDS by established CDC criteria.
- CD4 counts = or < 500 cells/mm3 on two evaluations.
Part II only:
- No prior therapy with antiretroviral or immunomodulating agents (e.g., AZT, ddI, ddC, interferon).
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms and conditions are excluded:
- Acute medical problems at time of study entry (including active opportunistic infections such as active cryptococcosis, Pneumocystis carinii, herpes zoster, histoplasmosis, or CMV, or nonopportunistic diseases including liver disease, renal disease, orthostatic hypotension, hypertension, lymphoma).
- Current diagnosis of malignancy for which systemic therapy would be required during the study.
Concurrent Medication:
- Any other investigational drugs.
- Phenobarbital, phenytoin, ketoconazole, rifampin, cimetidine, beta blockers, chronic anti-acid therapy, antiarrhythmic agents or other medications known to affect cardiac conduction or seizure threshold.
- Cytotoxic chemotherapy.
Patients with the following prior conditions are excluded:
- History of cardiovascular disease including conduction disturbances, arrhythmias, atherosclerotic heart disease, or valvular heart disease.
- History of CNS disease such as seizure disorder, AIDS Dementia Complex, Progressive Multifocal Leukoencephalopathy, or any other active neurological disorder.
- History of active or chronic gastrointestinal disorders such as chronic diarrhea (> 4 weeks duration), constipation, unexplained abdominal pain (such as irritable bowel syndrome), or other GI motility disorders.
- History of hypercholesterolemia requiring medication or serum cholesterol = or > 300.
Part I patients only:
- History of inability to tolerate zidovudine (200 mg q 8 hours).
Part III patients only:
- History of pancreatitis or > grade 2 peripheral neuropathy.
Prior Medication:
- Cytotoxic chemotherapy within 1 month prior to study entry.
Part II only:
- prior therapy with antiretroviral or immunomodulatory agents (including but not limited to AZT, ddI, ddC, and interferon).
Current use of alcohol or illicit drugs.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00000742
|United States, California
|Los Angeles, California, United States, 90033
|United States, Florida
|Univ. of Miami AIDS CRS
|Miami, Florida, United States
|United States, Missouri
|Washington U CRS
|St. Louis, Missouri, United States
|United States, New York
|Univ. of Rochester ACTG CRS
|Rochester, New York, United States, 14642
|United States, Ohio
|The Ohio State Univ. AIDS CRS
|Columbus, Ohio, United States
|Study Chair:
|Reichman R
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|NCT00000742 History of Changes
|Other Study ID Numbers:
11175 ( Registry Identifier: DAIDS ES Registry Number )
|Study First Received:
|November 2, 1999
|Last Updated:
|March 30, 2012
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
Drug Therapy, Combination
Acquired Immunodeficiency Syndrome
AIDS-Related Complex
Antiviral Agents
Additional relevant MeSH terms:
HIV Infections
Disease Susceptibility
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Disease Attributes
Pathologic Processes
Molecular Mechanisms of Pharmacological Action
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
|Date / Time
|Friday August 19, 2016 @08:04AM
|T-Mobile Brings Back Unlimited Data For All
|Monday March 28, 2016 @09:59AM
|Zero-Rating Harms Poor People, Public Interest Groups Tell FCC
|Thursday March 17, 2016 @12:43AM
|Facebook's 'Closed Silos' Pose Challenges To Open Web
|Monday February 29, 2016 @12:26PM
|Rubio, Cruz Try To Kill Neutrality On 1-Year Rule Anniversary
|Friday June 26, 2015 @08:35AM
|Study: Major ISPs Slowing Traffic Across the US
|Monday August 25, 2014 @08:30PM
|Net Neutrality Is 'Marxist,' According To a Koch-Backed Astroturf Group
|Monday July 07, 2014 @06:38PM
|YouTube Issuing "Report Cards" On Carriers' Streaming Speeds
|Sunday June 01, 2014 @08:56PM
|Comcast CEO Brian Roberts Opens Mouth, Inserts Foot
|Wednesday May 14, 2014 @07:50AM
|Major ISPs Threaten To Throttle Innovation and Slow Network Upgrades
|Tuesday April 29, 2014 @05:13PM
|Netflix Confirms Deal For Access To Verizon's Network
|Monday April 28, 2014 @10:16PM
|To Save the Internet We Need To Own the Means of Distribution
|Thursday April 24, 2014 @04:43PM
|New White House Petition For Net Neutrality
|Tuesday April 15, 2014 @08:09PM
|Netflix Gets What It Pays For: Comcast Streaming Speeds Skyrocket
|Thursday April 03, 2014 @08:24AM
|European Parliament Votes For Net Neutrality, Forbids Mobile Roaming Costs
|Monday March 24, 2014 @03:38PM
|Apple Reportedly In Talks With Comcast For Separate Apple Streaming Path
|Monday February 17, 2014 @09:57PM
|Killing Net Neutrality Could Be Good For You
|Monday January 06, 2014 @10:42PM
|AT&T Introduces "Sponsored Data" Allowing Services to Bypass 4G Data Caps
|Friday September 13, 2013 @02:28AM
|Verizon's Plan To Turn the Web Into Pay-Per-View
|Sunday March 24, 2013 @09:28AM
|FCC Chair Genachowski Resigns; What Effect on Net Regulation?
|Saturday March 23, 2013 @10:31PM
|FCC chair resigns; backed "net neutrality"
|Tuesday January 22, 2013 @01:54PM
|Why you'll pay for Netflix -- even if you don't subscribe to Netflix
|Saturday January 19, 2013 @11:48AM
|Orange claims to have forced Google to pay for traffic
|Tuesday December 11, 2012 @06:34PM
|Text spammer wants FCC to declare spam filters illegal.
|Saturday August 25, 2012 @03:52PM
|Republican Platform To Include Internet Freedom Plank
|Wednesday August 22, 2012 @10:16AM
|AT&T Defends Controversial FaceTime Policy Following Widespread Backlash
|Wednesday July 04, 2012 @11:38AM
|Verizon Claims Net Neutrality Violates Their Free Speech Rights
|Tuesday June 12, 2012 @01:08PM
|European ISPs Ask ITU To Limit Net Neutrality
|Monday June 11, 2012 @10:21AM
|European ISPs Ask ITU To Limit Net Neutrality
|Thursday May 17, 2012 @05:31PM
|Comcast To Remove Data Cap, Implement Tiered Pricing
|Thursday May 10, 2012 @06:23PM
|Netherlands cements Net Neutrality in Law
|Thursday May 03, 2012 @12:12PM
|Sony Put Video Service on Hold Due to Comcast Data Caps
|Wednesday March 28, 2012 @08:45AM
|Comcast Not Counting Their Video Service Against Bandwidth Cap
|Thursday February 02, 2012 @03:34PM
|Cisco's Complaint: EU Privacy Rules Enforce Net Neutrality
|Tuesday January 24, 2012 @03:43PM
|CRTC Says Rogers Violating Federal Net Neutrality Rules
|Wednesday December 21, 2011 @12:46PM
|Bell Canada to end throttle
|Wednesday November 09, 2011 @02:39PM
|Obama To Veto Anti-Net-Neutrality Legislation
|Friday October 07, 2011 @06:25PM
|EU Parliament Group Opposes Long Copyrights and Oppressive DRM
|Saturday September 17, 2011 @03:54PM
|CRTC Tells Rogers To Stop Throttling Online Gamers
|Friday August 05, 2011 @07:38PM
|Widespread Hijacking of Search Traffic In the US
|Wednesday August 03, 2011 @08:45PM
|Researcher's Tool Catches Net Neutrality Cheaters
|Saturday June 25, 2011 @01:05PM
|Proposing a Model For Locally Imposed Net Neutrality
|Tuesday June 21, 2011 @01:50PM
|Dutch party votes for internet filtering
|Thursday May 12, 2011 @02:31PM
|No Pirate Bay for Comcast Customers
|Wednesday April 27, 2011 @10:54AM
|Mediacom Using DPI To Hijack Searches, 404 Errors
|Tuesday April 05, 2011 @05:36PM
|House votes to overturn FCC on Net neutrality
|Tuesday April 05, 2011 @04:35AM
|Yahoo! Liable In Italy For Searchable Content
|Thursday March 10, 2011 @06:57PM
|UK ISPs To Make Voluntary Net-Neutrality Commitment
|Monday February 28, 2011 @05:59PM
|Comcast-NBC Deal Accidentally Protects Internet?
|Thursday February 17, 2011 @05:27PM
|Bandwidth being throttled in Bahrain?
|Wednesday January 26, 2011 @10:34PM
|Senators Bash ISP and Push Extensive Net Neutrality
|Wednesday January 26, 2011 @06:40PM
|What to ask Congressman regarding Net Neutrality?
|Sunday January 23, 2011 @05:57AM
|British ISPs Embracing Two-Tier Internet
|Thursday January 20, 2011 @02:38PM
|Mail Service Costs Netflix 20x More Than Streaming
|Tuesday January 18, 2011 @08:32PM
|Comcast-NBC Merger Approved By FCC
|Thursday January 13, 2011 @11:34AM
|Jimmy Wales Declares App Store Models a Threat
|Tuesday January 04, 2011 @08:20PM
|BT Content Connect May Impact Net Neutrality
|Tuesday January 04, 2011 @06:41PM
|Rushkoff Proposes We Fork the Internet
|Tuesday December 28, 2010 @10:42AM
|The Right's War On Net Neutrality
|Tuesday December 28, 2010 @09:52AM
|The Right's war on Net Neutrality
|Wednesday December 22, 2010 @06:55PM
|Republicans Vow to Take Down FCC's Net Neutrality
|Wednesday December 22, 2010 @06:06PM
|Is Net Neutrality Really Needed?
|Tuesday December 21, 2010 @06:14PM
|FCC Vote: Reactions Are Pouring In
|Tuesday December 21, 2010 @11:10AM
|Obama FCC Caves On Net Neutrality
|Monday December 20, 2010 @04:43PM
|Al Franken Makes a Case For Net Neutrality
|Saturday December 18, 2010 @09:57PM
|Look Forward To Per-Service, Per-Page Fees
|Tuesday November 30, 2010 @09:16AM
|Level 3 Shaken Down By Comcast Over Video Streaming
|Monday November 29, 2010 @06:28PM
|Level 3 Denounces Comcast 'Toll' On In
|Monday November 15, 2010 @12:58AM
|Wikipedia Could Block 67 Million Verizon Customers
|Sunday November 07, 2010 @08:30PM
|Net pioneers: Open Internet should be separate
|Wednesday November 03, 2010 @03:05PM
|End of Net Neutrality? Old crop of neutralists out
|Thursday October 28, 2010 @01:31PM
|95 Democratic candidates back net neutrality
|Wednesday October 20, 2010 @09:01AM
|ACLU Says Net Neutrality Necessary For Free Speech
|Sunday October 17, 2010 @01:20PM
|News Corp. Shuts Off Hulu Access To Cablevision
|Sunday October 17, 2010 @10:03AM
|News Corp. Shuts Off Hulu Access To Cablevision
|Thursday September 30, 2010 @11:04PM
|House Democrats Shelve Net Neutrality Proposal
|Tuesday September 28, 2010 @07:35PM
|UK's Two Biggest ISPs Rip Up Net Neutrality
|Thursday September 09, 2010 @11:23AM
|GoogleTV, AppleTV and the Battle For The Living Room
|Wednesday September 01, 2010 @10:30AM
|AT&T Says Net Rules Must Allow 'Paid Prioritization'
|Wednesday September 01, 2010 @09:01AM
|AT&T: Net rules must allow 'paid prioritizatio
|Monday August 23, 2010 @05:11AM
|UK ISP To Prioritize Gaming Traffic
|Friday August 20, 2010 @12:10AM
|RIAA Wants 'Net Neutrality' To Include Filtering
|Monday August 16, 2010 @04:36PM
|Democrats pan Google-Verizon net neutrality deal
|Friday August 13, 2010 @11:56AM
|EFF Reviews the Verizon-Google Net Neutrality Deal
|Friday August 13, 2010 @11:31AM
|Google Responds To Net Neutrality Reviews
|Monday August 09, 2010 @02:04PM
|Google & Verizon's Real Net Neutrality Proposa
|Thursday August 05, 2010 @04:04PM
|Google and Verizon In Talks To Prioritize Traffic (Updated)
|Tuesday August 03, 2010 @02:35PM
|No, Net Neutrality Doesn't Violate the 5th Amendment
|Monday August 02, 2010 @11:56AM
|Does Net Neutrality Violate the Fifth Amendment?
|Sunday August 01, 2010 @02:24PM
|Vixie Proposes Reputation Metric for BIND
|Sunday August 01, 2010 @01:10PM
|BIND to remove DNS Neutrality
|Wednesday July 28, 2010 @01:25PM
|Al Franken's Warning On Net Neutrality
|Tuesday July 27, 2010 @06:06AM
|UK ISP TalkTalk Caught Monitoring Its Customers
|Sunday July 25, 2010 @12:36AM
|Rogers Shrinks Download Limits As Netflix Arrives
|Friday July 16, 2010 @11:18AM
|Chile First To Approve Net Neutrality Law
|Thursday July 08, 2010 @08:35PM
|Major ISPs Challenge UK's Digital Economy Act
|Thursday June 24, 2010 @07:35PM
|Barbershop Punk: A Movie About Net Neutrality
|Thursday June 17, 2010 @05:44PM
|Net Neutrality Study: Devastating Job Losses
|Friday May 28, 2010 @12:58PM
|Congressmen Send Letters, Hope For Net Neutrality Fades
|Friday May 14, 2010 @01:40PM
|BT Gets Exclusive Rights To OnLive In the UK
|Tuesday May 11, 2010 @06:01PM
|The Telcos' Secret Anti-Net Neutrality Strategy
|Tuesday May 04, 2010 @04:59PM
|The Far-Reaching Effects of Comcast v FCC
|Wednesday April 28, 2010 @04:08PM
|Fair Use Generates $4.7 Trillion For US Economy
|Wednesday April 28, 2010 @02:50PM
|The Truth About Net Neutrality Job Loss
|Wednesday April 28, 2010 @02:23PM
|ISP Is Bypassing Firefox's Location Bar Search
|Tuesday April 20, 2010 @05:32PM
|RCN P2P Settlement Is Not Even a Slap On the Wrist
|Tuesday April 20, 2010 @08:44AM
|BitTorrent CEO On Net Neutrality
|Monday April 19, 2010 @10:19PM
|BitTorrent CEO on net neutrality
|Saturday April 17, 2010 @05:28PM
|Still Little To Do About a Bad ISP
|Tuesday April 13, 2010 @05:15PM
|In EU, Google Accused of YouTube "Free Ride"
|Tuesday April 06, 2010 @11:35AM
|Net Neutrality Suffers Major Setback
|Tuesday April 06, 2010 @03:06AM
|Benkler on Net Neutrality, Competition, and the Fu
|Tuesday February 16, 2010 @01:49PM
|A Simple Guide To Net Neutrality
|Tuesday February 09, 2010 @12:53AM
|Verizon Blocking 4chan
|Monday February 08, 2010 @10:22PM
|Netflix to FCC: ISPs could threaten Web video
|Thursday January 28, 2010 @03:10PM
|FCC's Net Neutrality Plan Blocks BitTorrent
|Monday January 18, 2010 @01:05PM
|Verizon and Google Offer Up Net Neutrality Truce
|Monday January 18, 2010 @01:01PM
|Verizon and Google Offer Up Net Neutrality Truce
|Saturday January 16, 2010 @02:17PM
|RIAA Wants Limits On Net Neutrality So ISPs Can Police File Sharing
|Sunday January 10, 2010 @07:36PM
|Court Unfriendly To FCC's Internet Slap At Comcast
|Monday December 28, 2009 @04:21PM
|The Need for Search Neutrality
|Monday December 21, 2009 @09:23PM
|Verizon Removes Search Choices For BlackBerrys
|Sunday December 13, 2009 @09:02PM
|Israeli ISPs Caught Interfering With P2P Traffic
|Friday December 11, 2009 @04:10PM
|AT&T's Net Neutrality Doublethink
|Friday December 04, 2009 @07:41PM
|Comcast to Buy 51% of NBC, GE Goes After 49%
|Friday October 30, 2009 @01:41PM
|Towards a Permission-Based Web
|Tuesday October 27, 2009 @10:14PM
|Internet Probably Couldn't Handle a Flu Pandemic
|Saturday October 24, 2009 @05:39AM
|FCC Begins Crafting Net Neutrality Regulations
|Thursday October 22, 2009 @07:06PM
|FCC begins crafting net neutrality regulations
|Thursday October 22, 2009 @04:52PM
|FCC Starts work on Net Neutrality Rules
|Thursday October 22, 2009 @03:25PM
|McCain Introduces Bill to Block Net Neutrality
|Thursday October 22, 2009 @01:56PM
|McCain Introduces Bill to Block FCC's Net Neutrali
|Saturday October 17, 2009 @03:26PM
|Democrats, Minority Groups Question Net Neutrality Push
|Friday October 16, 2009 @10:24PM
|Democrats, Minority Groups Question Net Neutrality
|Friday October 16, 2009 @02:35PM
|Cisco, Motorola, and Other Companies Take Aim At Net Neutrality Rules
|Thursday October 15, 2009 @06:30PM
|UPC Ireland latest to do a DNS hijacking trial
|Thursday October 15, 2009 @06:16PM
|Cisco, Nokia take aim at net neutrality
|Tuesday October 06, 2009 @05:22PM
|AT&T and Apple to allow VoIP on iPhone
|Monday October 05, 2009 @02:44PM
|Study Says Govt. Should Invest in Rural Broadband
|Friday September 25, 2009 @10:53AM
|Canadian ISPs Fight Back, Again
|Thursday September 24, 2009 @08:56AM
|Senators Against Net Neutrality
|Tuesday September 01, 2009 @05:13PM
|Military To Spend $42M To Build Advanced Network Control
|Monday August 17, 2009 @08:27AM
|Comcast Seeking Control of Both Pipes and Content?
|Wednesday July 29, 2009 @01:16PM
|Stopping Spam Before It Hits the Mail Server
|Friday June 12, 2009 @05:36PM
|Epix Provides "Free" HD Studio Content Via TV and Internet
|Friday June 12, 2009 @05:13AM
|BT Wants Cash For iPlayer, Video Bandwidth
|Thursday June 04, 2009 @05:10PM
|Canadian Regulator Says No To New Internet Regs
|Thursday May 21, 2009 @03:01AM
|How Microsoft Degrades Their Users (In a Good Cause)
|Wednesday May 06, 2009 @11:51AM
|European Union Asks US To Free ICANN
|Thursday April 30, 2009 @02:25PM
|Think-Tank Warns of Internet "Brownouts" Starting Next Year
|Tuesday April 21, 2009 @02:07PM
|BT Blocks Access To Pirate Bay
|Monday April 20, 2009 @12:22PM
|Europe on the brink of ending Net neutrality
|Tuesday April 14, 2009 @08:09AM
|ISP Capping Is Becoming the New DRM
|Monday April 13, 2009 @04:18PM
|Time Warner Transfer Caps May Inspire Fair-Price Legislation
|Wednesday April 08, 2009 @10:54AM
|An Education In Deep Packet Inspection
|Monday March 16, 2009 @01:48PM
|Morality of Throttling a Local ISP?
|Saturday March 14, 2009 @08:53AM
|How Moore's Law Saved Us From the Gopher Web
|Tuesday March 10, 2009 @11:22AM
|UK Government Wants To Kill Net Neutrality In EU
|Thursday March 05, 2009 @11:13PM
|ZillionTV Offers On-Demand Streaming TV Box, But Only Via ISPs
|Wednesday March 04, 2009 @01:25PM
|Obama Picks Net Neutrality Backer As FCC Chief
|Tuesday March 03, 2009 @11:32PM
|Canadian ISPs Speak Out Against Net Neutrality
|Wednesday February 11, 2009 @02:52PM
|Senator Diane Feinstein Trying to Kill Net Neutrality
|Saturday February 07, 2009 @09:30AM
|ESPN's Play To Make ISPs Pay
|Saturday January 17, 2009 @11:10PM
|Stimulus Bill Contains Net Neutrality Provision
|Monday December 29, 2008 @06:25PM
|BBC's iPlayer Chief Pushes Tiered Charging For ISPs
|Saturday December 27, 2008 @04:04PM
|Fairpoint Pledges To Violate Net Neutrality
|Monday November 17, 2008 @08:59AM
|Net Neutrality Vets Join Obama FCC Transition Team
|Friday October 31, 2008 @01:25PM
|Sprint Cuts Cogent Off the Internet
|Monday October 27, 2008 @11:23PM
|Microsoft Announces Windows Azure, Cloud-Based OS
|Monday October 13, 2008 @01:20PM
|Canadian NDP Leader Praises P2P Communities
|Thursday October 09, 2008 @01:09PM
|Obama & McCain Conflicting On Net Neutrality
|Friday October 03, 2008 @08:44AM
|Internet Filtering Lobby Forms
|Wednesday October 01, 2008 @11:28PM
|Vint Cerf Says It's Every Machine For Itself
|Monday September 29, 2008 @04:15PM
|Australian ISPs Claim Net Neutrality Is an 'American Problem'
|Friday September 05, 2008 @02:56PM
|Comcast Appeals FCC's Net Neutrality Ruling
|Tuesday August 19, 2008 @05:00PM
|DPI and Net Neutrality's Overseas Weak Spot
|Monday June 30, 2008 @11:50AM
|Encrypted Traffic No Longer Safe From Throttling
|Sunday June 22, 2008 @03:31PM
|Sandvine CEO Says Internet Monitoring a Necessity
|Monday June 16, 2008 @10:51AM
|Google To Develop ISP Throttling Detector
|Monday June 16, 2008 @10:50AM
|Net Neutrality vs. Technical Reality
|Tuesday May 27, 2008 @09:18AM
|Canadians Organizing a Rally For Net Neutrality
|Thursday May 15, 2008 @09:49PM
|Comcast, Cox Slow BitTorrent Traffic All Day
|Tuesday May 06, 2008 @11:25AM
|Google Nervous About Verizon's Open Access
|Monday April 14, 2008 @01:28AM
|Virgin Media CEO Says Net Neutrality Is Already Gone
|Wednesday April 09, 2008 @02:39PM
|BBC and ISPs Clash over iPlayer
|Monday April 07, 2008 @02:54PM
|Comcast Blocks Web Browsing
|Friday April 04, 2008 @11:01AM
|Father of Internet Warns Against Net Neutrality
|Friday April 04, 2008 @10:47AM
|Yes Virginia, ISPs Have Silently Blocked Web Sites
|Friday April 04, 2008 @10:33AM
|Net Neutrality Debate Intensifies In Canada
|Thursday March 27, 2008 @12:20PM
|Comcast Makes Nice with BitTorrent
|Friday March 14, 2008 @07:33AM
|Net Neutrality Blasted by MPAA Bosses
|Wednesday March 12, 2008 @03:09AM
|IFPI Turning To Lawsuits
|Tuesday March 11, 2008 @08:58PM
|FCC Considers Taking Action Against Comcast
|Sunday March 09, 2008 @03:58PM
|Jonathan Zittrain On the Future of the Internet
|Friday February 22, 2008 @08:03AM
|BBC iPlayer Usage Effect - A Bandwidth Explosion
|Thursday February 14, 2008 @03:26AM
|New 'Net Neutrality' Bill Introduced
|Wednesday February 13, 2008 @10:26PM
|Comcast Defends Role As Internet Traffic Cop
|Thursday February 07, 2008 @10:53PM
|Comcast's New Terms of Service Disclose Traffic Management
|Sunday February 03, 2008 @11:22AM
|Time Warner Filtering iTunes Traffic?
|Thursday January 17, 2008 @07:59PM
|AT&T's Plan to Play Internet Cop
|Wednesday January 09, 2008 @01:32PM
|FCC To investigate Comcast Bittorrent Meddling
If you can't learn to do it well, learn to enjoy doing it badly.


text:
Apple's CEO Tim Cook talks new products.
Image 1 of 2
Tim Cook, chief executive officer of Apple Inc., speaks during an event in San Jose, California, U.S., on Tuesday, Oct. 23, 2012. Apple Inc. is taking the wraps off a smaller iPad today, betting that a less expensive version of its tablet computer will help the company fend off competitors including Microsoft Corp., Amazon.com Inc. and Google Inc. Photographer: Noah Berger/Bloomberg *** Local Caption *** Tim Cook
Go back to reading "Apple avoids 'thermonuclear war' is settling HTC patent dispute"Copyright 2017 Bloomberg. All rights reserved.


text:
NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Sunday, September 24, 2017
Skin Care and Diseases
Sun poison
how do you know if you have sun poison on you body?
It depends on what you mean by sun poisoning. There are two reactions that commonly are referred to as "sun poisoning". The first is called Polymorphous Light Eruption. Women are more likely to get this than men. It occurs in susceptible individuals when they are exposed to sunlight that is more intense than usual, for example as in the first time you go out in the sun during the summer or when you expose a body part to sunlight that has no prior sunlight exposure. It may also occur if you travel to a higher latitude or lower latitude such as to a country closer to the equator where the sunlight has more strength. Normally the resulting skin-rash reaction heals within 7-10 days with no treatment as long as additional sun exposure is avoided. In the future using sunscreen that protects against UVA and UVB rays is mandatory. (Sunlight is made up of UVA and UVB rays). Make sure the sunscreen protects against both UVB and UVA since these protective agents are more effective in preventing these breakouts. The second is called Solar Urticaria. It is a rare reaction to sun exposure. This is a true sun allergy. It develops rapidly--moments after exposure, the skin begins to itch, and then becomes red. Wheals or vesicles appear. The actual mechanism that causes this reaction is unknown, however, antihistamines are effective in treating the reactions of some patients.
Tatiana M Oberyszyn, PhD
Associate Professor of Pathology
Associate Professor of Molecular Virology, Immunology & Medical Genetics
College of Medicine
The Ohio State University


text: The whole plate is $200 + shipping. AM dosent have the 03/03 Cobra versions, only the GTs It sux but I gave the dude permission to notch it so I cant complain. Just gotta bend over and grab my ankles and hope one day I at least get a reach around.


text:
Note: This item is more than 12 years old. Please take the publication date into consideration for any date references.
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News Release
Media Contact: TPWD News, firstname.lastname@example.com, 512-389-8030
Feb. 22, 2005
Big Bend Ranch State Park Conditions Prime for Digital Photo Workshop
PRESIDIO, Texas — Big Bend Ranch State Park should be in full bloom this spring, thanks to above-average moisture, providing a host of colorful subjects for camera buffs enrolled in digital photo workshops scheduled this April.
Veteran Houston photographer Jim Carr will teach two sets of workshops: the first bring April 22-24 and the second April 26-28. The workshops will concentrate on digital photography fundamentals and what equipment and computer software are available today to take quality pictures and enhance ones that need help, Carr said.
"One of the main disappointments that I hear from people who visit the ranch is their inability to capture the mountains and grandeur of the West Texas landscapes that make the Big Bend so special," Carr said. "While capturing such an image has always been possible, (though not easily) digital cameras and software programs have made taking quality panoramic photos much easier."
Carr knows Big Bend Ranch well. He has been conducting trail rides and photo workshops at the scenic 300,000-acre state park and working cattle ranch for 10 years.
He says workshop participants will be divided into four groups of photographers at the ranch. Photographers will learn how to download their photos to a computer disc and how to adjust colors, size photos and perform other editing tasks using the latest photo editing software.
The cost of the workshop is $400, which includes meals, lodging, all park fees and transportation in connection with the on-site workshop. Workshop participants will meet at Fort Leaton State Historic Site in Presidio and be transported to the state park.
To register for the workshop, call Big Bend Ranch State Park at (432) 229-3416.
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(5.4.16 i)


text:
First, we need to remember that there are lies, statistics and misinterpreted statistics.Its interesting to note that according to Ziggy, almost 50% of the brand new modules on CPAN were uploaded in 2003.
The numer I came up with is from analyzing the modules list. This includes some duplication (mod_perl is listed twice; there are three distributions of AcePerl at the top of the list) and some exclusions (perl-5.8.x.tar.gz is not listed, nor is Meta).
Analyzing the modules list cannot show the growth of CPAN, but can be used as a first approximation on the freshness of CPAN. I did not say that ~50% of the new modules on CPAN were created since January 2003. I did say that 44% (quoting from memory) of CPAN modules listed on the modules list were created or modified at least once since January 2003. The modules list cannot show the former. It can give an indication of the latter.
The modules list does not (in general) reflect prior distributions of current modules (either currently on CPAN or deleted by the author) that would be found by analyzing an ls-lR of CPAN or backpan. Groveling over an ls-lR dump of either will find things that aren't modules (and arguably should not be counted), while the modules list will find too little. I find the modules list to provide a good first approximation, no more, no less.
OR you're misinterpreting the statement "almost 50% of current module distributions on CPAN have been created or modified since January 2003".This means over time either we're creating new modules faster than we're maintaining the existing ones OR we just got a huge influx of new authors OR Ziggy's wrong.
The difference is rather significant.
My intent was to see if Perl was stagnating, or if people still care about Perl. Using uploads to CPAN as a proxy, I found that ~85% of what's current on CPAN (as listed in the modules list) was created or modified after the Perl6 announcement.
We can argue over methodologies and precise figures, but I assert that the intent is sound, and these figures serve as a good first approximation -- no more, no less.
The conclusion that I draw from these numbers is that as a community, we have not given up on Perl 5, nor have we stopped caring about Perl 5 since the Perl 6 announcement. I didn't expect anyone to infer that people stopped supporting old modules, or that the list of CPAN authors increased geometrically.
OR you're misinterpreting the statement "almost 50% of current module distributions on CPAN have been created or modified since January 2003".
OR I got my information second hand and it was misquoted.
The ls -lR stats and your module list stats make a hell of a lot more sense now
Do that computation again, but this time leave off the Acme namespace and use the ls-lR since the modules list is incomplete and still manually maintained.
The conclusion is obvious, if not terribly important, but statistics lie too often, especially around those who like pie charts. CPAN is the only thing that is doing well in the perl world right now...you don't need a bar graph to tell anyone that.
Do that computation again, but this time leave off the Acme namespace
That's a good idea. Thanks.
use the ls-lR since the modules list is incomplete and still manually maintained.
The ls-lR for either CPAN or BACKPAN doesn't suit my needs at the moment. Eventually, I want to do a more detailed analysis of BACKPAN, but not this week. Thanks for making that ls-lR.
The conclusion is obvious, if not terribly important, but statistics lie too often, especially around those who like pie charts. CPAN
Parroting received wisdom ("CPAN is the only thing that is doing well in Perl", "You can do more with Perl because it is «more expressive»", "Perl 6 is the future of Perl") doesn't do anyone any favors.
Parroting? You say that like we don't pay attention to CPAN. We do, but we don't publish statistics just because we run the joint. Publishing inaccurate and misleading statistics don't do anyone any favours most of all. Statistics are the tool with which people lie to others as well as to thems
You say that like we don't pay attention to CPAN.
No, I say that because a lot of pro-Perl scentiments are repeated endlessly without any critical analysis. If you actually read what I said, you'd see that I'm not singling out CPAN, nor am I not accusing CPAN's maintainers of not paying attention.
I also never attributed any mystical properties to an uploaded distribution, so please don't say that I did. As I said before, the only thing an upload means is that someone created or updated a file on C
No, but you were taking the conclusion and generating numbers rather casually to prop it up which isn't critical analysis either.
And I wouldn't call my earlier conclusion positive or 'pro-perl' either.
Pick a fight if you must. I'm just trying to see what's going on.
I'm not picking a fight, just saying you shouldn't take a statement and try to make it legit by mostly unrelated numbers with a weak methodology...
You always gotta get the last word in, don't you?


text: What's your favorite short lived canceled TV show? I'll start off with three. All are on Netflix streaming, check them out! Eli Stone: More of a dramedy, but this show had SO much heart. Every episode had one of those feel good moments. So sad it was canceled after 2 seasons. Life: Ony 2 seasons. Damian Lewis as a cop who found Zen while in prison partnered with Sarah Shahi who has a past of her own. Great rapport between the two mains, and just great episodic TV with progressive underlying stories. Better Off Ted: Only 2 seasons. Comedy about corporate America that was so much funnier than the Office ever tried to be. I never knew Portia de Rossi could be so funny (I never watched AD).


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If you are expecting or a new mom, then you have to check out the Zooper stroller sale going on at Totsy right now! These strollers are marked WAY down — up to 40% off. For instance, the Zooper Waltz is normally priced at $299, but you can snatch one up at Totsy right now for $179.95!
Learn more about the Zooper Waltz:
The Zooper Waltz, like all of Zooper's innovative products, is renowned for its high-quality and durable materials, array of safety options, and eye-catching design. Sure to have you dancing with joy, the Waltz is one of the most technically advanced strollers on the market today, boasting a wide range of family friendly features. First, it's a dream to drive, with its lightweight aluminum frame, die-cast wheel housings, independent front and rear suspension, and one-step rear link break. Second, it keeps baby super-comfy and extra-secure with its soft fabrics, cushioned headrests, four-position reclining seat, five-point safety harness, and all-purpose (sun and rain) canopy. Throw in deluxe amenities like an easy-access basket, cup holder, select car seat compatibility, and an incredible fold-up capability, and this stroller isn't only magnificent for baby, it's convenient for mom too! An effortlessly executed item that will be the envy of all your friends, the Zooper Waltz is the reliable and stylish stroller you've been searching for.
The good news is that you can also WIN a Zooper Waltz in Flax Brown right here on Jolly Mom too!
I am a compensated member of the Totsy Mom Committee. Affiliate links are used in the above post. All opinions expressed in this article are my own and not influenced in any way by anyone. Please refer to this site's Terms of Use for more information.


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19 fun car road trip activities
Turn an ordinary drive into a world of fun adventures and possibilities. more
With over 32% of the Australian population now considered obese, nutritionists and dieticians are looking more closely than ever at the causes of this huge health issue. The main issue, they say, is that we are eating more calories than we are burning - in other words, we are eating too much and exercising too little.
Sugar consumption is of major concern - particularly in convenience foods, because these foods are consumed in large quantities, are generally low in nutritional value and high in added sugars.
There are four main types of simple sugars: glucose, dextrose, fructose and lactose. Table sugar, also called sucrose, is a sugar compound of fructose and glucose. Each sugar has a different effect on the human body and so it's important to be sugar-smart about what you and your family eats.
Glucose is our body's primary source of energy. Most of the glucose in our diet comes from the sugar and starch found in carbohydrates - and it is this type of sugar that diabetics can't naturally regulate.
Rice, grains, potatoes, pasta, fruits and some vegetables are all rich in carbohydrates, and so are high in glucose. Once carbohydrates are broken down into glucose, this functional form of energy is absorbed into the bloodstream, where it combines with the chemical insulin. Combined together, they enter the body's cells and provide the energy needed to power our bodies.
Dextrose is a form of glucose and works in the same way on our body. When we have consumed too much dextrose, our bodies convert it to fat or glycogen. Glycogen can later be used by muscle tissue as a direct energy source for muscles - and for this reason, it is often included in nutritional supplements for body builders. Dextrose is about half as sweet as sucrose.
Fructose is found in most fruits and is the sweetest of the naturally occurring sugars. Fructose has a low glycemic index which means that there is a slow release of this type of sugar into the body, rather than the sudden rush associated with glucose. For this reason, diabetics can consume foods that contain fructose.
Lactose is a milk sugar and is a compound of glucose and another simple sugar, galactose. Lactose is found in milk, including human milk and is not found naturally in any other types of foods beyond dairy products. Lactose intolerance occurs when our body doesn't produce enough of an enzyme called lactase that assists in the breaking down of the milk sugars.
Sucrose is more commonly called table sugar. A compound of fructose and glucose and naturally occurs in sugar cane. Often referred to as having 'empty calories', sucrose is high in calories but has no nutritional value at all. Other than supplying energy, sucrose does nothing to support the body.
Corn syrup is not a naturally occurring sugar. Made from the processing of corn into cornstarch which is mainly glucose, enzymes are then added which convert much of the glucose to fructose. With a sweetness that is similar to sucrose, corn syrup - and its most commonly produced variety, high fructose corn syrup - has replaced sucrose as the most commonly used sweetener in the manufacture of foods in the US, although it is rarely used in Australia because cane sugar is cheaper and more readily available.
Health concerns have been raised by experts about the heavy use of high fructose corn syrup in food manufacturing, and recently there has been a trend away from its use and back towards sucrose.
Interestingly, the Corn Refiners Association in the US (by far the biggest consumers of the syrup) have applied to change the name of 'high fructose corn syrup' to 'corn sugar' on food labels with the argument that consumers should know exactly what they are eating.
In 2003 four UN agencies, including the World Health Organisation, commissioned a report on nutritional advice. The report recommends that, 'the total of free sugars [that is, sugars added to foods by manufacturers, cooks or consumers, plus sugars naturally present in honey, syrups, and fruit juices] should not account for more than 10% of the energy intake of a healthy diet, while carbohydrates [that are broken down into sugars by the body] in total should represent between 55% and 75% of the energy intake."
Cutting down on sugars is one way you can help your family to stay healthy and consume the right amount of energy-intake foods. While most families will struggle to completely cut sugar from their diet - and for most of us, there really is no need to be that extreme either, you can minimise it by first of all identifying the main sugar culprits in your home and removing these. Look at the sugar content on product packets to identify the worst offenders. Next, you need to restock your pantry and fridge with non-sugary foods. Stocking up on healthy snacks is really important because convenience snack foods are often the most high-sugar foods in the house. Instead try:
All breads contain sugar. Try and stick to the brown and grainy breads because these are low-sugar and have twice as much fibre as white breads.
When it comes to sugars, there is no such thing as a bad nut. While some do have low levels of fructose, they have huge amounts of fibre so make a perfect snack food.
Meats contain no sugars at all. Just be careful what you eat with meat - many pre-packaged sauces and marinades are full of sugars so check the labels carefully before dousing your steak in tomato sauce.
Yes, there is obviously going to be fructose in fruit - but fruit also contains good amounts of fibre and water. Just be sure to eat WHOLE fruit rather than juicing it. By juicing fruit, you are in effect removing all the fibre and just consuming the water and fructose.
Again, all vegetables contain some fructose but it is usually in small amounts. By contrast vegetables generally have a high fibre content, as well as high levels of vitamins and minerals. For that reason, there should be no limit to the amount of vegetables you consume.
Avoid sweetened yoghurts and milk and you will keep sugar levels relatively low. All dairy products do include lactose, but unless you are lactose intolerant, this should not be a concern.
Last revised: Tuesday, 28 September 2010
This article contains general information only and is not intended to replace advice from a qualified health professional.