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Church of the Transfiguration Presents MUSIC BY WOMEN TODAY, 11/13
The Church of the Transfiguration ("The Little Church Around the Corner") presents "Music by Women Today" on Tuesday, November 13, 2012 at 7:30pm. The program consists of classical and jazz compositions written and performed by women.
The program features Martha Sullivan's O Antiphons and Julie Dolphin's Stone Soup, both performed by the Transfiguration Vocal Ensemble, Claudia Dumschat, director; Of Shadows Numberless by Miriam Gideon, performed by Margaret Mills; Soundscape for Organ and Electronics by Melissa Grey; NOW by Michele Goritz; Fedora by Jessica Rudman, with Brandon Tesh, saxophone; and compositions by Joyce DiCamillo: Song Cycle for Voice and Piano, featuring soprano Lesley Zlabinger accompanied by the composer, and Freelancin', performed by the Joyce DiCamillo Trio.
This is an Arnold Schwartz Memorial Concert. For a full schedule, visit: www.littlechurch.org/ - /music.
Tuesday, November 13, 2012 7:30pm
The Church of the Transfiguration "The Little Church Around the Corner"
One East 29th Street (between Fifth and Madison Avenues) New York, NY
Tickets: $25; $15 for students
Reservations & info: (212) 684-4174
Subways: 1, N, R or 6 to 28th Street; B, D, F or M to 34th Street Herald Square
By bus: M1, M2, M3, M5, M6 or M7
Claudia Dumschat (Conductor) is the Organist and Choirmaster at Church of the Transfiguration. She received her Doctor of Musical Arts from the Manhattan School of Music and studied conducting with Dennis Keene and Giampolo Bracali. Her repertoire includes orchestral and choral music, chamber music, oratorios, and operas by major composers in the Western tradition up to the present day. Theatre/dance collaborations with neXus Arts and/or the Church of the Transfiguration include Britten's Curlew River, Noye's Fludde, Company of Heaven; Menotti's The Unicorn, the Gorgon, and the Manticore; Händel's Saul and Athalia. World premiere performances include Victor Kioulaphides' The Gilded Cage and The Vision of Perpetua, Brian Schober's Dance of the Stones, and the NY premiere of Stephen Hartke's Tituli. Dr. Dumschat was Music Director of The Play of Daniel last December and The Prodigal Son in March here at Transfiguration.
Composer Martha Sullivan's music has been praised as "vibrant" and "a singer's favorite". She has earned commissions from such leading voices in American choral music as the Dale Warland Singers and the Gregg Smith Singers (with whom she was a resident composer, 2002–2008), as well as the Esoterics (Seattle, WA), Bella Voce (Reno, NV), Chicago A Cappella, the New York Treble Singers, the Manhattan Choral Ensemble, and Vocativ (Zürich, Switzerland). Numerous ensembles have performed her work, including such New York fixtures as Voices of Ascension, Cerddorion, and Equal Voices, as well as ensembles countrywide, such as San Francisco's Volti, Minneapolis' The Singers, and the Southern Oregon Repertory Singers. Her work has been championed by Stephen Tharp, the international organ recitalist, and recorded by The Esoterics, Chicago A Cappella, and mezzo-soprano Virginia Dupuy. Her work appears in the book Singing for Dummies. She has received several Meet the Composer grants for her work with Gregg Smith, as well as recognition from the National Endowment for the Arts for her work with the Esoterics; she was the 2009 Bronze Medalist in the Sorel Medallion competition for women composers, and she won the Dale Warland Singers' Choral Ventures competition in its final year (2003).
Composer Julie Dolphin holds an advanced degree in Ethnomusicology from Columbia University, and her unique style makes use of her knowledge of classical Western forms and world musics, drawing on the rhythms of both jazz and Bartok. Her choral commissions have been premiered at Carnegie Hall, Merkin Concert Hall, The Cathedral of Saint Patrick, and other venues in the tristate area. She has provided music for private weddings and for the Westchester County Department of Parks in its Year 2000 celebration. Her three-part piece, "One Life," featured Jon Humphrey as the tenor soloist in an evening of music commemorating the events of September 11. As a soprano, Ms. Dolphin has toured nationally and internationally with the Waverly Consort, Voices of Ascension, Musica Viva and the Collegiate Chorale. "Stone Soup" has long been a favorite childhood tale, and a serendipitous encounter with the beloved book for sale in a local Brooklyn branch library was the impetus for a commission by Kristina Boerger and Cerddorion Vocal Ensemble, funded by the Argosy Foundation. "Stone Soup: a Mini-Oratorio Containing a Denial, and a Seduction in the Form of a Tango" endeavors to live up to its title. It was premiered in 2009 at the Church of Saint Ignatius of Antioch in New York City.
Composer Miriam Gideon (1906–1996) was born in Greeley, Colorado, where her father was a Reform rabbi. Her interest in composition -begun in childhood as an ancillary, experimental, and almost private activity-soon became the primary focus of her creative energies. At Boston University, where she earned her bachelor's degree with a major in French literature and a minor in mathematics, Gideon continued to study music, and she returned to New York after graduation with a view toward a career in public school teaching. But the urge to compose absorbed her more and more.
One of the most important imprints on Gideon's future was her private study, for several years during her late twenties, with the now fabled émigré Jewish composer from Russia, Lazare Saminsky. Saminsky was then the music director and organist at New York's Temple Emanu-El. After a few years of private lessons, he suggested that Gideon study with the esteemed American composer and composition teacher Roger Sessions, who had been a pupil of Ernest Bloch's. Gideon worked with Sessions for eight years, gradually developing her distinctive and deeply expressive combination of extratonal and pantonal idioms that would define her music thereafter.
In 1946 she earned her master's degree in musicology from Columbia University, but even before matriculation she began teaching at Brooklyn College. The eminent composer and intellect Hugo Weisgall, the chairman of the faculty at the Jewish Theological Seminary's Cantors Institute and Seminary College of Jewish Music (now the H. L. Miller Cantorial School), invited her to teach there, and thus began a fruitful, rewarding, and mutually beneficial affiliation for some forty years. Weisgall became a fervent champion of her music, and in 1970 she earned her doctorate (Doctor of Sacred Music) from the Seminary under his guidance. Like Weisgall, Gideon had a particular affinity for literature and its expression as vocal music, saying that she was "moved by great poetry and great prose almost as much as by music." She was especially prone to set literature in the context of vocal chamber music-voice with small instrumental ensembles-in which the vocal line often functions as one of the instruments. Even more remarkable was her fondness for dual-language and even multilingual settings.
Her first Jewish work was her English setting of Psalm 84-known liturgically in its original Hebrew as Ma tovu but composed and published by her as How Goodly Are Thy Tents. Written for women's voices, it won the Ernest Bloch Choral Award in 1947. Then came her first Hebrew setting -Adon olam-in 1954, commissioned and premiered by Hugo Weisgall at the Chizuk Amuno Congregation in Baltimore. Three Masques for organ followed in 1958, commissioned by composer and virtuoso organist Herman Berlinski. Gideon based that work on cantillation motifs for the annual Purim rendition of the Book of Esther. Gideon's two Jewish magna opera, however, are unquestionably her two artistically sophisticated Sabbath services. The first, for Sabbath morning, Sacred Service (for the Sabbath), was commissioned in 1971 by The Temple in suburban Cleveland. This work was scored for baritone and tenor soloists, with mixed chorus and an ensemble of six wind and string instruments together with organ. Her second service, comprising principal elements of the liturgies for kabbalat shabbat and Sabbath eve (ma'ariv), is titled Shirat Miriam L'shabbat. Commissioned and premiered by Cantor David Putterman for the annual Friday evening service of new music at New York's Park Avenue Synagogue in 1974, it is scored more conventionally for tenor cantor, mixed choir, and organ. In fashioning this service, Gideon accepted some of Cantor Putterman's well-meant advice to consider tradition a bit more than she had done in her first service so that the work would stand a better chance of a life afterward. Taken together, these two services demonstrate her refined craft, her ability to express emotional depth and strength with subtlety, and the power of her exquisite economy.
Gideon was fond of relating how, upon hearing her Seasons of Time, a critic once remarked to her that he had "never heard so many right notes." Gideon felt that defined considerations of sonorities and technical devices wrongly mask the more important matters of emotional impulses-with which she believed there was insufficient concern in postwar 20th-century music. She cautioned that many composers were so eager to demonstrate facility that they didn't allow themselves to become personally involved in their own music.
"As far as I am concerned," she said, "I must see whether what I am writing comes from a musical impulse, and whether I am responding to it. What I write has to mean something to me.... It has to seem new. I have to be surprised by it, and it must register as feeling." "I didn't know I was a woman composer until 'the movement' in the 1960s," she reminisced in the mid-1980s. "I knew I was a young composer, and then, suddenly, an older composer. But never a woman composer."
Pianist Margaret Mills has performed throughout the United States, Europe and China. She has degrees from Vassar College, and the New England Conservatory of Music in Boston. Ms. Mills has given solo recitals in Alice Tully Hall and Merkin Concert Hall in New York City and at the National Gallery of Art in Washington, DC. She made her London debut in Wigmore Hall in 1981, the first of several European performances in the following decades. Ms. Mills has appeared as soloist with the Boston Pops, Fort Myers Symphony, Schenectady (NY) Symphony and the Fairfield Orchestra. She has been a featured pianist with the Fine Arts, Manhattan, Cassatt and Laurentian String Quartets. Her recordings include the Newport Classic, Cambria Master Recordings and Capstone labels.
Composer and interdisciplinary artist Melissa Grey. Works premiered and exhibited at Judson Memorial Church, 14th Bi-Annual International Electro-Acoustic Music Festival (CUNY); Streaming Festival 3rd ed., Pantheon International Xperimental Film & Animation Festival 7.0, Chicago City Arts Gallery, Artradio at Cornerhouse, Studio 27, Macon Georgia Film and Video Festival, Reno Interdisciplinary Festival of New Media, Tilt Gallery Project Space, among others. Grants/Awards: American Music Center, Lower Manhattan Cultural Council, and two ASCAPlus Special Awards from the American Society of Composers, Authors and Publishers for Concert Music.
Composer Michele Goritz, multifaceted musician. As a composer, pianist, flautist and educator, Michele creates in a variety of styles and genres, offering an unique experience in music today. Graduate of the Manhattan School of Music with a degree in Piano Performance. Founder of the ETUDES MUSIC STUDIO: Teacher of piano, flute, theory, and performance techniques from 1993 to present. Even before completing her studies in Classical Music at the Manhattan School of Music, Michele Goritz was performing both piano and flute, as a soloist and in ensembles. She has since pursued studies in New Music (both as a composer and a pianist). Michele sought out and was selected by jazz legend Kenny Werner to be one of the privileged students he teaches, while he continues his own performing, composing, touring and recording career. Michele's ability to accompany dancers in a variety of musical genres is highly regarded and has brought her work from members and directors of American Ballet Theatre, New York City Ballet, Classics Dance Theatre of Stamford and Hubbard Street Dance Chicago. Her riveting performance of the European premiere of electro-acoustical "Tracer" by composer David Taddie in July 2005 was performed with dance accompaniment, and was the only piece selected by the concert's promoter for publicity on Italian television.
Composer Jessica Rudman's music has been presented across the USA and abroad. She has participated in festivals including the Seasons Festival, the Cortona Sessions, EAMA, Music07, and NEON. Honors include winning the 2012 NewMusic@ECU Orchestra Composition Competition, IAWM's Libby Larsen Prize (2011), Honorable Mention for the Brian M. Israel Award (2011), and first prize in the Con/un/drum Percussion Competition (2009). Ms. Rudman has taught at Central Connecticut State University, The Hartt School, and Baruch College. She is currently pursuing a Ph.D. at the City University of New York as a student of Tania León. For more information, please visit: http://www.jessicarudman.com.
Composer Joyce DiCamillo, a Syracuse University School of Music graduate, has led her own jazz trio for over thirty years, recording 5 trio CDs - A Touch of Jazz, Freelancin' featuring tenor saxophonist Houston Person, Moment to Moment, Love Letters, and Sunrise Lady. Included on the prestigious International Roster of Steinway Artists, she has performed at the Mary Lou Williams Women in Jazz Festival at the Kennedy Center as well as the Kennedy Center Jazz Club, Southport (UK) Jazz Festival, Guinness Jazz Festival (Cork, Ireland), Andria (Italy) Jazz Festival, Syracuse Jazzfest, The Jazz Cruise, and Litchfield Jazz Festival, to name but a few. She was featured on NPR's Piano Jazz hosted by Marian McPartland, and has also toured as pianist for internationally known pop vocalist Donna Summer. A consultant in music education, Joyce has appeared as a clinician or artist in residence at over 100 high schools and colleges around the country, has a full teaching practice and is Executive Director of the Stamford Young Artists Philharmonic as well as founder of SoNYC Media, a Tribeca-based digital music business.
Soprano Lesley Zlabinger is quickly becoming known as a Baroque specialist. She has performed as a soloist in several Bach cantatas at the Church of the Transfiguration in Manhattan and at Queens College. She has also performed the soprano roles in Handel's Messiah with orchestra at Queens College and York College, Buxtehude's Membra Jesu Nostri at the Church of the Transfiguration, and Vivaldi's Gloria in Mineola.
Equally at home in opera, Ms. Zlabinger has performed roles from the Baroque era through the 21st century. Highlights include Virtù in Monteverdi's L'Incoronazione di Poppea, Belinda in Purcell's Dido & Aeneas, the Countess in Mozart's Le Nozze di Figaro, Sophie in Strauss' Der Rosenkavalier and Blanche in Poulenc's Dialogues of the Carmelites. Ms. Zlabinger has also originated roles in three new operas: Cupid in Cupid & Psyche and Parisatis in Alexander the Great, or the Rival Queens, both by Matthew Pittsinger; and Soprano Soloist in Brian Schober's Dance of the Stones, produced by neXus Arts.
A seasoned chorister, Ms. Zlabinger has sung with a variety of touring, recording, and professional choirs. She is a member of the professional choir at Corpus Christi Church in Manhattan, the choir-in-residence of the Music Before 1800 concert series. She also sang with the Queens College Vocal Ensemble on its recording Selected Partsongs of Hamish MacCunn (2010), some of which had never previously been recorded. Additional choral credits include the Bel Canto Voices, Minneapolis, MN; Grinnell Singers, Grinnell, IA; and the Studentenkantorei, Freiburg, Germany.
Ms. Zlabinger is also an accomplished recitalist. Past recital repertoire includes Debussy's Quatre chansons du jeunesse, Argento's Six Elizabethan Songs, selections from Wolf's Italienisches Liederbuch, and Schubert's Der Hirt auf dem Felsen. She also presented a variety of sacred and secular Baroque duets at the Church of the Transfiguration in New York City on its mid-day concert series.
Ms. Zlabinger holds an M.A. in Vocal Performance from Queens College / CUNY and a B.A. in German from Grinnell College. She teaches voice privately and through the Great Neck Arts Center. Please visit www.LesleyZlabinger.com for performance listings, audio clips, and more.
Pictured: Claudia Dumschat


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Red Sox not considering demotion for Bogaerts
BOSTON -- While third baseman Xander Bogaerts continues to struggle at the plate, Red Sox manager John Farrell said before Wednesday's series finale against the Cubs that the team will not demote him to Triple-A Pawtucket.
"We haven't even considered that," Farrell said.
The 21-year-old came into the game in an 0-for-19 slump and had just two hits in 42-at-bats since June 18. He went 0-for-4 in Wednesday's 16-9 loss.
"Obviously, he cares. He's accountable for his actions, both in preparation and the ultimate results," Farrell said. "What we monitor is if that becomes a distraction inside the lines and right now it's not.
"He is working on some things, particularly with his balance and trying to keep his legs underneath him rather than lunging to the front side. Those are things we're hopeful that start to show up in games."
The team has chosen to take a patient approach with Bogaerts, who is in his first full Major League season and is batting .242 with six home runs and 19 RBIs through Wednesday.
"It might be a little bit more prevalent for a guy that's still creating a foundation here at the big league level where those swings of confidence might be a little bit wider," Farrell said. "But this is also somebody that we believe in and we continue to have him in the lineup and provide opportunities."
Quinn Roberts is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.

subset: commoncrawl


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CFI Education
Monday, July 15, 2013 from 12:30 PM to 2:30 PM (PDT)
Join us for a free matinee screening
and post-film discussion
Directed by Kirby Dick
Monday, July 15, 12:30 pm - 2:30 pm
Please note: This film is longer than previous Community Cinema films
Christopher B. Smith Rafael Film Center
1118 Fourth Street, San Rafael, CA 94901
www.cafilm.org, (415) 454-1222
The Invisible War is a groundbreaking investigative documentary about one of America's most shameful and best kept secrets: the epidemic of rape within the U.S. military. The film, a nominee for the 2013 Academy Awards, paints a startling picture of the extent of the problem: Today, a female soldier in combat zones is more likely to be raped by a fellow soldier than killed by enemy fire.
The Department of Defense estimates there were a staggering 22,800 violent sex crimes in the military in 2011. Among all active-duty female soldiers, 20 percent are sexually assaulted. Female soldiers age 18 to 21 accounted for more than half of the victims.
Focusing on the powerfully emotional stories of rape victims, The Invisible War exposes the systemic cover-up of military sex crimes, chronicling the women's struggles to rebuild their lives and fight for justice. It also features hard-hitting interviews with high-ranking military officials and members of Congress that reveal the perfect storm of conditions that exist for rape in the military, its long-hidden history, and what can be done to bring about much-needed change.
At the core of the film are interviews with the rape survivors themselves — people like Kori Cioca, who was beaten and raped by her supervisor in the U.S. Coast Guard; Ariana Klay, a Marine who served in Iraq before being raped by a senior officer and his friend, then threatened with death; and Trina McDonald who was drugged and raped repeatedly by military policemen on her remote Naval station in Adak, Alaska. And it isn't just women; according to one study's estimate, one percent of men in the military — nearly 20,000 — were sexually assaulted in 2009.
And while rape victims in the civilian world can turn to a police force and judicial system for help and justice, rape victims in the military must turn to their commanders — a move that is all too often met with foot-dragging at best, and reprisals at worst. To make matters worse, 33 percent of rape victims didn't report the assault because the person they'd have to report it to was a friend of the rapist. And 25 percent didn't report it because the person they'd have to report the rape to was the rapist himself.
Many rape victims find themselves forced to choose between speaking up and keeping their careers. Little wonder that only 8 percent of military sexual assault cases are prosecuted.
Is there hope that this broken system can be fixed? Many think so, and credit The Invisible War with inspiring some much-needed recent action. "This film has been instrumental in bringing the issue to light, and providing the impetus for positive change," says Lois Vossen, Independent Lens senior series producer.
Since The Invisible War premiered at Sundance, the film has been circulating through the highest levels of the Pentagon and the Obama administration. Two day after Secretary of Defense Leon Panetta watched The Invisible War, he directed military commanders to hand over all sexual assault investigations to a higher-ranking colonel. At the same time, Panetta announced that each branch of the armed forces would establish a Special Victims Unit. A congressional panel is set to hold hearings on sexual abuse in the military in early 2013.
Producer/director Kirby Dick is known for making highly influential, award-winning films. The Invisible War is an Oscar nominee for Best Documentary Feature, and has been the impetus for possible change on a national level. His previous film, Outrage, examined the hypocrisy of powerful, closeted politicians and was nominated for an Emmy. In 2006 he directed This Film is Not Yet Rated. A breakthrough expose of the highly secretive MPAA film ratings system, the film compelled the MPAA to make long overdue changes in the way it rates films. Dick's prior film, Twist of Faith, is the story of a man confronting the trauma of his past sexual abuse by a Catholic priest. It received a 2004 Academy Award nomination for Best Documentary Feature. Dick's other films include Derrida, Sick: The Life and Death of Bob Flanagan, and Supermasochist.
Producer Amy Ziering is an award-winning and Emmy-nominated documentary producer and director who previously worked with Kirby Dick on the films Outrage and Derrida. Ziering also produced The Memory Thief, which was a New York Times critics' pick and won several festival awards, and Taylor's Campaign. Ziering taught at Yale during her graduate studies there. She initiated and runs the ongoing Films 4 Change activist film series.
Q & A immediately followng the film with:
Katie Weber, a North Bay Resident, is a 100% Service Connected disabled veteran of the U.S. Army for PTSD from MST (military sexual trauma). She is an advocate for MST survivors and Women Veterans. She is a Volunteer at Military Rape Crisis Center (MRCC) and Protect Our Defenders, two separate organizations founded to eradicate Military Sexual Trauma. Katie founded a support group for other MST Survivors and has appeared in several news and media stories about the subject. Katie also works with Congresswoman Jackie Speier (D-CA) to raise awareness and amend legislation currently requiring military rape victims to initially report the attack to their chain of command instead of law enforcement. Katie also appeared in the new Sundance Audience Award Winning and Academy Award Nominated Documentary "The Invisible War". She also has hosted screenings, been a presenter on panels and Q and A sessions following the showing of this documentary. Screenings included audiences consisting of Legal Experts, Nurses, Students, Faculty, Clinicians, Veterans and the Active Duty military.
Victoria SandersI joined the army in 1975, at age 19, hoping to be able to become a nurse. That was a goal I did make in 1983 but it was a tough road. Along the way I learned that women were not welcome in "That man's military". Responding to a sergeant's directive, I stepped into the busy barracks hall at noon at Fort Carson in Colorado to find myself suddenly crowded by a group of three men who backed me into a room. As two of them kept watch outside, the sergeant raped me. I still consider myself one of the lucky ones. My boss called the MP's and at least there was a record. So many just refuse to report this crime and later are unable to prove what happened. I was lucky but is still took 1240 days before I got the rating of 100% disabled. I was lucky I got great care when I showed up at the Vet Center in San Jose in 2004 the PTSD had taken over my life completely. This year marks a new phase for me I went and lobbied in Washington DC in April. Now I want to use the experiences I have had to help others. My hope in speaking out is to show the ones who are suffering there is life after rape it is just not the same one you had planned for.
To view the trailer:
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CFI Education is proud to be a part of Community Cinema. Community Cinema is a ground-breaking public education and civic engagement initiative featuring monthly screenings of films from the Emmy Award-winning PBS series Independent Lens. For more information about Community Cinema and for study guides visit www.pbs.org/independentlens/communitycinema
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More than a one-word answer needed.
I've said the same thing over and over... one of our main problems from last year is that the current roster doesn't allow a stable rotation. This problem hasn't been fixed yet, although getting rid of Brad and Mercer helped (although it's obviously hurt in other ways).
Do you guys agree with me on this? I haven't heard much discussion one way or another. I know I'm often too comfortable on my hobby horse, but I really do see this as an issue. If this is really a problem, then it's not one that coaching can fix. If there are changes to be made, Bird/Walsh need to make them.


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I always felt it was not the Lindy Ruff I knew, said Woolley, who played for the Florida Panthers when Ruff was an assistant coach there. I saw a lot of older guys get driven out of there. You look at Dougie (Gilmour) and Andy (Dave Andreychuk), guys that came with a lot of expectations and great attitudes, leaving miserable and not liking the game.
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As a unit of the Purchasing Department under Business Services, the Duplicating Center produces a wide variety of published materials for all our school and department needs, as well as other local public agencies and non-profits, such as PTA, Athletic Boosters, San Ramon Valley Fire Prevention District and the Historical Society.
Materials produced range from class worksheets, flyers, pamphlets, brochures and booklets, to district forms, course catalogs and testing materials for all students. Quality service, timely delivery, and cost effectiveness are key elements of this department.
Our production printer has high volume capabilities, able to use up to five different paper stocks in one job and staple or tape bind. The attached scanner allows for manipulation of originals to job specifications; formatting pages, paper colors, image size, quality and finishing. Files can be saved for future re-prints. Other shop equipment includes a COLOR copier, thermal tape and spiral bindery machines, cutter, drill, stitchers, folding machines and collators.
The Duplicating Center is located at the Service Center. Jobs may be submitted in person, via e-mail to email@example.com , or scanned from a networked copier directly to our DigiPath system. A completed Duplicating Request form (BU:PUR:10301) must accompany all orders. When providing an electronic file to print, "pdf" format is recommended. Completed jobs are delivered by either Inter-District mail (depending on size) or Warehouse Freight (see Warehouse delivery schedule).
We gladly provide quotes! Call or e-mail us anytime.


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Redlands, Calif. -- Esri announced Wednesday that the Great Atlantic and Pacific Tea Co. has licensed Esri GIS technology and data to provide localized shopping trends data toward supporting the grocer's commitment to growing its market presence across the Northeast.
"Partnering with Esri allows us to enhance our real estate strategy in the neighborhoods that we currently serve by enabling us to meet the specific needs of our customers," said Nrup Krishnamurthy, A&P chief information officer. "In addition, this technology will serve as an essential business tool to help us make well-informed decisions about where and how we go to market in the future."
Esri's location analytics provide A&P staff with valuable data on store locations, including key demographics and shopping trends in local communities. By analyzing geodemographic data, part of the Business Analyst solution, A&P can continue to grow and develop its stores, according to the grocer.


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Topic: HAPPY BIRTHDAY 3 YEARS CC FREE!!!!!!!!!!!!!!!!
You know life is normal when you forget to post on the CC site your cancer free birthday. May 24, 2012 was my 3 year anniversary of my first transplant making me cancer free. The last 4 years have been long and full of lots of bumps but I am here to tell you there is HOPE!!! Please say a prayer for my donor's family as this day for them is full of sorrow.
Lots of prayers for my CC family and that someday the "Good News" column is longer than the "Introduction" column.


text: Kansas-based, family-owned McCarty Dairy has entered an exclusive multi-year agreement with The Dannon Company to become the Company's sole supplier for fresh milk for its yogurt plant in Fort Worth, Texas. As Dannon's fresh milk supplier, McCarty Dairy will provide its milk directly to Dannon. This is the first time Dannon has entered into this type of partnership with a family-owned dairy. Through the partnership, both McCarty Dairy and Dannon will reduce the impact of milk pricing volatility on their respective businesses and will simultaneously create a closer, more direct relationship between farmer and consumer. McCarty Dairy and Dannon share ambitious goals for environmental stewardship and sustainability, which can now be implemented based on the direct collaboration. McCarty Dairy is a fourth-generation dairy located in Northwest Kansas, currently managed by Tom and Judy McCarty, and their sons Mike, Clay and Ken. McCarty Dairy milks approximately 1,600 cows three times a day, averaging over 121,000 lbs of milk per day (approximately 9 gallons per cow, per day). 10.18.2011


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Open Hire for 2011 RECQuest and Therapeutic Recreation Summer Staff
Therapeutic Recreation is now hiring! We are seeking staff to work with individuals with disabilities during the summer. Applicants must be 18 years of age or older and have at least 250 hours of experience in a recreation or school setting serving individuals with disabilities. College course work can supplement the experience hours. Staff selected for the program will be required to acquire CPR and First Aid Certification for children and adults that is valid through August, 2011.
If you are interested, please attend one of the following open hire dates:
March 10
May 19
June 1 -- (CANCELED)
Noon – 5:00 p.m.
Pennino Building
12011 Government Center Parkway
10th Floor
Fairfax, VA 22035
April 5
4:30 – 9:00 p.m.
Irving Middle School
8100 Old Keene Mill Road
Springfield, VA 22152
All applicants will need to bring the following to open hire:
- Original Social Security card
- DMV photo identification
- Voided check to set up direct deposit
If you are a resident alien, you must also bring:
- INS Form I-151 and INS Form I-551
All positions are open until filled.
For more information, please call 703-324-5587, TTY 711.
Fairfax County is committed to nondiscrimination on the basis of disability in all county programs, services and activities. Reasonable accommodations will be provided upon request. For more information, call 703-324-4600, TTY 711.


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'"We don't have to kid ourselves, we have what, 29 games left? We probably need to win 21 of them to even have a chance. It's a big task, but I think this is a group that can put a streak together, but it starts with one. Not just to win, but it starts with having a good win, playing a good 60 minutes. A lot of our mistakes come from us turning it over and not getting out of the zone, but I don't think we're that far off. I know we've said that for week now and we keep losing, but as long as you believe, and I think the guys do then there's a chance."'
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AFL all but knew Bombers were under investigation: documents
Stunning documents released in the Federal Court on Friday allege the AFL all but knew Essendon was the club being investigated by the Australian Crime Commission last year.
Former AFL chief Andrew Demetriou has previously denied he was told by the ACC in a January 31 meeting last year in Canberra that the Bombers were being probed for alleged use of performance-enhancing drugs.
But ahead of Monday's Federal Court hearing brought by Essendon and James Hird, in which they will allege that the joint investigation by the Australian Sports Anti-Doping Authority and the AFL was unlawful, it has emerged that then AFL deputy chief Gillon McLachlan also attended a meeting alongside Demetriou with the ACC. McLachlan asked the ACC: "Is it Essendon?" ACC investigator Paul Jevtovic replied: "Say no more".
The documents then add: "This was the confirmation to all those in the room that the [Essendon Football Club] was the club under suspicion."
Among hundreds of notes submitted by all parties, Demetriou commented: "A lot not a surprise".
Demetriou has also denied tipping off former Essendon chairman David Evans on February 4.
It has also been revealed former prime minister Julia Gillard pressured ASADA to bring a quick resolution to the supplements saga.
Former anti-doping chief Aurora Andruska has detailed a meeting she had four days after the Bombers self-reported fears of suspected drug use on February 5.
It is alleged at a meeting involving Andruska, McLachlan, Evans, Bombers chief executive Ian Robson and AFL integrity chief Brett Clothier that: "The Commonwealth government took an interest in the investigation from the outset. At a meeting in Canberra on 9 February 2013 between Ms Andruska, Messrs Clothier, McLachlan, Evans and Robson ... it was noted that 'PM wants it to end' and there was a reference to 'criticism of gov'.
"By June 2013, ASADA was coming under pressure from the relevant Commonwealth minister, Kate Lundy MP, to reach some form of conclusion, or 'an outcome' from the investigation."
The Bombers and Hird have submitted a 95-page document.
It has also emerged that Essendon players allege they were threatened with criminal charges if they did not co-operate with the joint AFL-ASADA investigation.
The Bombers and Hird maintain ASADA and the AFL completed a joint investigation, something the parties allege ASADA did not have the power to complete.
Jon Pierik is a sports writer with The Age, focusing primarily on AFL football, cricket and basketball. He has won awards for his cricket and basketball writing.
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text:
Topic: Almost ran into Kris from Sweden today in Chapel Hill, NC
Hey Kris, I can't believe it. Charlie had an appt. with Dr. Sanoff at 12:30 today. For some reason, I kept thinking about you a lot and come to find out, you were in the room right next to ours and Dr. Sanoff came from your room to ours. I told Dr. Sanoff about mentioning her name to you and she said she would be surprised if we hadn't passed in the hall and had just come from your room. I heard you laughing. I told Dr. Sanoff you have a great sense of humor. She said you were a sweetheart. I hope you liked her and got the information you needed. Maybe Dr. Sanoff will become a cc expert...Wishing you all the best.


text:
Dottie Applique Bath Towels
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- Dimensions + Care
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This item will arrive in 3-5 business days. Please proceed to the Payment & Review page of Checkout for a precise delivery estimate.


text:
Topic: Medications suggestion for nausea/vomiting
Older anti-nausea/vomiting drugs included
1. Group 1(antidopaminergics).- prochloperazine 10mg;promethazine 25mgand reglan 10mg.come as orla and injectable dosage form.
2. Group 2 like cyclizine, meclizine 25mg ,dimenhydrinate, benadryl 25-50mg ,scopolamine patch and tigan 200mg,oral and injectable are belong to anticholinergics group.
3.Group 3 like corticosteroids (dexametasone) oral,and injectable,cannabinoids 2.5mg and hydroxyzine 10-25mg oral and injectable, benzodiazepines like ativan and Xanax,oral and injectable form are belongs to the miscellaneous group.(Xanax and Ativan oral tablet can be used itself as sublingual too.)
Try to ask your doctor to switch to another group of med if the one your father took is not working well or try a combination from different groups.
There are 3 phases of nausea/vomiting;
1.Anticipatory emesis (before chemo treatment)
2.Acute emesis (during the first 24hrs)
3.delayed emesis.(24-96hr after chemo)
Newer antiemetics are as the following;
1. 5-HT3 receptor antagonist group- ondansertron (Zofran), dolasetron(Anzemet), granisertron (Kytril) are the first generation and palonosetron(Aloxi) is the second generation of 5-HT3 receptor antagonist.
2. the NK1 receptor antagonist like aprepitant (Emend) and others on the market are newer than the 5-HT3 receptor antagonists;they come as an oral capsule or tablet and injectable dosage form(fosaprepitant).Emend has to be taken with other antiemetics and on schedule for the maximum anti -nausea/vomiting control.
On one of the ASCO 6/2011 poster session abstract#9091,indicated
"significant clinical benefits in favor of palonosetron(Aloxi) were also seen in the delayed and overall time periods on the number of emetics episodes and the severity of nausea."when compare to the other 3 5-HT3 receptor antagonists."
Another phase 3 study indicated that the use of a three-drug regimen aprepitant(Emend) ondansetron(zofran),and dexamethasone were significantly better than the use of the two-drug regimen like dexamethasone +Zofran or dexamethasone+ Emend in controlling nausea/vomiting in patient receiving cisplatin.(80% vs43-57%).
There is evidence to suggest that the second generation 5-HT3 receptor antagonist palonosetron(Aloxi) is superior to other 5-HT3 older receptor antagonists like Zofran for the treatment of delayed emesis due to cisplatin-based chemotherapy.
Olanzapine an antipsychotic agent,combined with dexamethasone in a phrase 3 trial,following cycle 1 ,is as effective as Emend combined with dexamethasone in preventing acute nausea(90%vs87) and acute vomiting(100%vs90);delayed vomiting(77%vs73) and better control of nausea in the delayed peroid (68%vs37),the result were maintained during cycles 2to4.Further clinical trials are needed to replicate the result.-from uptodate.com,prevention and tx of chemotherapy-induced nausea and vomiting.lit.review ver.19.1,Jan.2011.
One more note,the risk of delayed emesis (ie:>24hr )after cisplatin is between 60-90% in the absence of effective prophylaxis treatment with antiemetics. Using just 5-HT3 receptor antagonists ALONE without dexamethasone to prevent delayed emesis in patient receiving cisplatin is not recommended.
For anticipatory nausea prevention ,XanaX 0.5mg-2mg or Ativan 1mg with or without Benadryl 25mg-50mg 20-30min before chemo works too .
Ginger root has been used for a long time for controlling nausea in Asia. a study of 644 patients were randomly assigned to placebo or ginger (0.5-1gm capsule twice daily for six days) ;starting three days prior to the first day of the next 2 cycle of chemo treatment.all of the patients received 5-HT3 receptor antagonist on day 1 of all cycles.Significant reduction in nausea throughout day 1 of the chemo cycles was observed.
To find out the cause of nausea and vomiting besides thinking it is only comes from the chemo is important too. (ie; is the patient on antibiotics too?does the patient have no bowel movement?Is he on too much opiates? etc.)
God bless.


text:
Back to the Fifties With AC/DCTrivia brain teasers have some element of trivia in them, but they are not just pure trivia questions.
"It was amazing! I have to tell you about the entire trip!" exclaimed Tinman, the town lunatic.
"I was tinkering around with my microwave, because it's always breaking down. Suddenly, right after I connected two wires, I was shot into a white abyss where I was brought back to the year 1950. When I was walkin' around I noticed there was a concert goin' on. I went inside and eventually I got to play. It was so amazing! I went up there and started playing AC/DC. The people were so amazed, probably because they've never heard distortion like that before!" Then, someone said that he was lying and told everyone how that would be impossible. What did he use as proof?
HintIt isn't about the time traveling.
AnswerIn the year 1950 there was no distortion on amplifiers, so there would be no way he could play any AC/DC song with it.
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
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text:
Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring
Recruitment status was: Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The aim of this study is to evaluate standard investigations performed in patients with bolus impaction in a prospective observational field study. In bolus impaction, ingested food boluses have to be endoscopically removed. Oesophageal narrowing by scar tissue caused by reflux disease or motility disorders are possible causes of bolus impaction. How common these causes are has up to date never been investigated. The discovery of eosinophilic oesophagitis has broadened differential diagnosis of bolus impaction. Currently high resolution oesophageal manometry and 24-hour pHmetry are performed in addition to endoscopy in the assessment of bolus impaction at the University Hospital Zurich.
The collection of these examination results is the aim of this prospective unrandomised observational field study to assess weather the currently applied procedures are valid to diagnose the cause of impaction to find optimal therapy for each patient.
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Observational Field Study of Acute Esophageal Food Bolus Impaction by Mean Esophageal Manometry and 24h-pH-monitoring
|Estimated Enrollment:
|Study Start Date:
|August 2011
|Estimated Study Completion Date:
|December 2013
|Estimated Primary Completion Date:
|December 2013 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|18 Years to 90 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Probability Sample
Inclusion criteria:
- Patients with acute esophageal bolus impaction coming to the emergency unit of the University Hospital Zurich needing emergency endoscopy for bolus removal
- Age > 18 years
- Informed consent
Exclusion criteria:
- Age under 18 years
- Inability to understand the informed consent form
Please refer to this study by its ClinicalTrials.gov identifier: NCT01447823
|Contact: Andreas Steingoetter
|+41 (0)44 255 5684
|Contact: Michael Fried, Professor, MD
|+41 (0)44 255 2401
|University Hospital Zurich, Gastroenterology and Hepatology
|Zurich, Switzerland
|Study Director:
|01 Studienregister MasterAdmins
|UniversitaetsSpital Zuerich
|Principal Investigator:
|Michael Fried, Professor, MD
|University Hospital Zurich, Division of Gastroenterology and Hepatology
|Responsible Party:
|University of Zurich
|ClinicalTrials.gov Identifier:
|NCT01447823 History of Changes
|Other Study ID Numbers:
KEK-ZH Nr 2011-0192
|Study First Received:
|September 27, 2011
|Last Updated:
|October 7, 2011
Keywords provided by University of Zurich:
Oesophageal bolus obstruction
Additional relevant MeSH terms:
Esophageal Motility Disorders
Esophageal Spasm, Diffuse
Deglutition Disorders
Esophageal Diseases
Gastrointestinal Diseases
Digestive System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
Quiting Marijuana Use: Self-report Study of Quitting Straegies and Withdrawal Symptoms
This study has been completed.
National Institute on Drug Abuse (NIDA)
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
First received: May 19, 2012
Last updated: June 30, 2017
Last verified: May 3, 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
- Marijuana is the most widely used illicit drug in the world, yet relatively little is known about users who try to quit without formal treatment ( spontaneous quitting). Studies have suggested that there are some common strategies that many individuals use in spontaneous quitting, such as changing one s lifestyle or identity, reminding oneself of negative consequences, support from family and friends, and religion. However, more research is needed to determine potential treatment strategies for marijuana use.
- To identify strategies used to help with marijuana quitting among non-treatment seeking adult marijuana users.
- To identify withdrawal symptoms experienced during marijuana quitting and their relationship to the quitting strategies used and the outcome of the quit attempt.
- To evaluate whether subgroups of marijuana users differ in their experience of marijuana quitting.
- Individuals at least 18 years of age who have made at least one attempt to quit marijuana use.
- The study will consist of one visit of approximately 1 to 2 hours.
- Participants will fill out three questionnaires. The questionnaires have different types of questions, and will ask about background and lifestyle, marijuana use and craving patterns and behaviors, and difficulties in previous attempts to quit using marijuana.
|Cannabis Abuse Cannabis Dependence
|Study Type:
|Official Title:
|Quitting Marijuana Use: Self-Report Study of Quitting Strategies and Withdrawal Symptoms
Resource links provided by NLM:
MedlinePlus related topics: MarijuanaU.S. FDA Resources
Further study details as provided by National Institutes of Health Clinical Center (CC):
Primary Outcome Measures:
- Marijuana Quit Questionnaire [ Time Frame: 1 to 2 hours ]
Secondary Outcome Measures:
- Marijuana Craving Questionnaire, and Additional Questions about Marijuana Craving
|Estimated Enrollment:
|Study Start Date:
|November 8, 2005
|Estimated Study Completion Date:
|May 3, 2012
Marijuana is the most widely used illicit drug in the world, yet relatively little is known about users who try to quit without formal treatment (so-called spontaneous quitting). This study will use two self-report questionnaires to collect information on the socio-demographic characteristics, marijuana use history, most difficult marijuana quit experience, and marijuana craving from a convenience sample of 1230 adult, non-treatment-seeking marijuana users. The questionnaires take 45-60 minutes to administer. Data will be analyzed for patterns and correlations among the characteristics of the quit attempt, including any withdrawal symptoms, quitting strategies used, and its success. The marijuana craving data will be analyzed to evaluate the validity of this measure of marijuana craving. There are no direct benefits to subjects from study participation. The scientific benefit is an improved understanding of spontaneous quitting of marijuana use, which may lead to improved interventions for marijuana users in the future. There are no physical risks to subjects. There are risks of anxiety or embarrassment while taking the questionnaire and of loss of confidentiality of sensitive information collected about subjects.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- age 18 or older
- have made at least one attempt to quit marijuana use
- able to give valid informed consent
- ability to understand English
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01603992
Please refer to this study by its ClinicalTrials.gov identifier: NCT01603992
|United States, Maryland
|National Institute on Drug Abuse, Biomedical Research Center (BRC)
|Baltimore, Maryland, United States, 21224
|Maryland Psychiatric Research Center (MPRC) 55 Wade Avenue
|Catonsville, Maryland, United States, 21228
|United States, South Carolina
|Medical University of S. Carolina
|Charleston, South Carolina, United States, 29425
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
|Principal Investigator:
|David A Gorelick, M.D.
|National Institute on Drug Abuse (NIDA)
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by National Institutes of Health Clinical Center (CC):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Adamson SJ, Sellman JD. A prototype screening instrument for cannabis use disorder: the Cannabis Use Disorders Identification Test (CUDIT) in an alcohol-dependent clinical sample. Drug Alcohol Rev. 2003 Sep;22(3):309-15.
Boyd SJ, Tashkin DP, Huestis MA, Heishman SJ, Dermand JC, Simmons MS, Gorelick DA. Strategies for quitting among non-treatment-seeking marijuana smokers. Am J Addict. 2005 Jan-Feb;14(1):35-42.
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Koola MM, Boggs DL, Kelly DL, Liu F, Linthicum JA, Turner HE, McMahon RP, Gorelick DA. Relief of cannabis withdrawal symptoms and cannabis quitting strategies in people with schizophrenia. Psychiatry Res. 2013 Oct 30;209(3):273-8. doi: 10.1016/j.psychres.2013.07.044. Epub 2013 Aug 20.
|ClinicalTrials.gov Identifier:
|NCT01603992 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|May 19, 2012
|Last Updated:
|June 30, 2017
Keywords provided by National Institutes of Health Clinical Center (CC):
Drug Use
Additional relevant MeSH terms:
Marijuana Abuse
Substance Withdrawal Syndrome
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
ClinicalTrials.gov processed this record on September 21, 2017


text:
Above a wood-burning fireplace is not the place to leave out a fire stop! Also note, there is no insulation in those center stud bays. And this house was sold has having a tight thermal envelope! The builder refused to correct these oversights.
Views: 41
© 2017 Created by Lawrence Berkeley National Laboratory. Powered by


text:
But that all changed three years ago when the move of Parkview Hospital's main campus from Randallia Drive to Dupont Road created the need for a "back door" to the $536 million facility and induced the Indiana Department of Transportation (INDOT) to begin work on an interchange at Union Chapel instead, sparking a legal battle that encompassed everything from private property rights and wealth to public safety and economic development.
In the end, everyone involved may benefit. But it didn't always look that way.
That's because INDOT's original design called for the construction of a "non-mountable" barrier in the middle of Union Chapel Road stretching 1,000 feet east of the new interchange – a feature that might have improved traffic flow and safety but would have created limited "right in, right out" access to the Pelkingtons' property.
And that's a problem when you not only operate a concrete business but also have nine children living at home, own eight cars and make about 40 trips every day. It's perhaps an even bigger problem when you begin thinking about moving to get away from the unexpected hubbub – and realize your property's development value is potentially diminished by the proposed lack of full access to it.
So the Pelkingtons did what any red-blooded Americans would do when the state tried to buy seven acres needed for the interchange's northbound off ramp: They went to court, claiming the design constituted an illegal "taking" of their property without just compensation.
"We didn't want to delay the (interchange), but the only way out of the box was to come up with our own design for access," said Tom Niezer, one of Fort Wayne's most influential land-use lawyers. So the Pelkingtons paid about $35,000 to design a roundabout on Union Chapel several hundred feet east of the new interchange near the entrance to their property and Parkview Plaza Drive, which leads to the hospital campus.
"But then they said, 'There's no traffic study,' " Niezer added. So the Pelkingtons and Parkview split the cost of a $10,000 review that ultimately convinced state and local officials that another roundabout between the one at the interchange and one planned at Union Chapel and Diebold roads would not impede or jeopardize motorists.
Just one problem: Government officials may have said it would be OK to build the additional roundabout, but they never offered to pay for it. So if the Pelkingtons and Parkview want it – and it appears they do – they'll have to provide the land and the $1.8 million or so needed for construction.
Negotiations are ongoing, but finances should not be a major problem. The Pelkingtons in January settled their lawsuit for $326,800, their land has plenty of development potential and Molly's father is John Tippmann Sr., a prominent local businessman. Parkview, meanwhile, has already paid $14 million toward the cost of the I-69 interchange and improvements to Diebold. What's another few hundred thousand dollars?
In the meantime, Niezer said, INDOT will shorten the barrier so the Pelkingtons have access to their driveway from either direction.
And so, just maybe, everybody really will live happily ever after. The Pelkingtons and Parkview get better access to their property, the family may get a higher price for its land, which may be more attractive to businesses that would pay taxes and create jobs, and the public gets improved roads and economic development at no public expense.
Still, Niezer raises a key point: If state and local officials are as serious about creating jobs as officials claim it is, why design a project that could limit development near a potentially lucrative Interstate interchange?
"But what truly is 'economic development?' " asked Dan Avery, executive director of the Northeastern Indiana Regional Coordinating Council, a transportation planning agency. Avery has no problem with the proposed roundabout but also defends the original design, arguing that safe, well-functioning roads are also conducive to job growth.
Would the likely outcome have been different had not Parkview and a politically savvy and affluent family not been involved? Quite possibly. But that doesn't mean we shouldn't take happy endings where we find them.


text:
Study of Pharmacokinetics in HIV-infected Women
This study has been completed.
Women's College Hospital
Canadian Institutes of Health Research (CIHR)
Information provided by:
Women's College Hospital
ClinicalTrials.gov Identifier:
First received: February 9, 2007
Last updated: July 27, 2012
Last verified: July 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Women represent an increasing proportion of HIV cases globally and in Canada, yet are underrepresented in clinic trials. It is therefore critical to conduct this study on antiretroviral (ARV) pharmacokinetics (PK) in women to obtain additional information on ARV drug levels in women and their relation to adverse events (AEs).
The hypothesis for this study is three-fold:
- that the mean drug levels (Cmin and Cmax) of ARVs will be significantly higher in our female population as compared to the mean drug levels in the historical HIV population (which is primarily men)
- that ARV drug levels, particularly Cmin, are associated with body weight in women
- that higher ARV drug levels, particularly Cmax, are associated with higher frequency and severity of AEs.
The objectives of this study are as follows:
Primary objectives:
- To demonstrate that levels of Protease Inhibitors (PIs) and Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are significantly higher in our female population as compared to the mean drug levels in the historical general population (which is primarily men).
- To determine the association between PI and NNRTI minimum concentration (Cmin) and body weight in our female population.
Secondary objectives
- To determine the association between maximum concentration (Cmax) and the frequency and severity of AEs as measured by the proportion of patients with grade 2 or higher laboratory or clinical AEs and the Symptom Index Score in women.
- To determine the association between ARV drug levels and age, race, height, body mass index, adherence, hormonal levels and therapy, menstruation history, duration of HIV infection, duration on ARV therapy, baseline viral load, baseline CD4 count, present CD4 count, hepatitis B or C infection, class of ARVs, presence of ritonavir and other medications.
|HIV Infections
|Drug: antiretroviral treatment
|Study Type:
|Study Design:
|Time Perspective: Prospective
|Official Title:
|Predictors of Antiretroviral Pharmacokinetics in HIV-infected Women With Virologic Suppression on Combination Antiretroviral Therapy
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDSU.S. FDA Resources
Further study details as provided by Women's College Hospital:
Biospecimen Retention: Samples Without DNA
Blood samples will be drawn before and after antiretroviral drugs are taken for visits 1-3.
|Study Start Date:
|February 2007
|Study Completion Date:
|February 2009
|Primary Completion Date:
|February 2009 (Final data collection date for primary outcome measure)
Intervention Details:Show Detailed Description
Drug: antiretroviral treatment
These antiretroviral drugs are a part of the participant's current drug regimen.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
The patient population will consist of 80 HIV-infected women (who are on their first cART regimen containing either a PI or an NNRTI for at least three months and who have evidence of full virologic suppression (HIV RNA VL < 50 copies/mL) on at least two occasions at least one month apart. The first cART regimen can include ARV switches as long as these switches are not due to virologic failure. The patient population is being limited to women who have full virologic suppression to avoid inclusion of women with difficulty with drug adherence.
Inclusion Criteria:
- Patient must be HIV infected
- Patient must be 18 years old or older
- Patient must be a biologic woman
- Patient must be taking her first combination ARV regimen that includes a PI or an NNRTI for the past three months with no changes in any agent of the combination in that period (first combination ARV regimen is defined as a regimen started when the patient was ARV-naïve; however switches are allowed as long as the switches are not for virologic failure)
- Patient must be taking either a PI or an NNRTI but not both
- If taking a PI, patient must be taking only one PI excluding low dose ritonavir used as boosting
- Patient must have a viral load < 50 copies/mL on two occasions at least 1 month apart including a value within three months before the baseline visit
- Patient has to have signed and dated a full informed consent
Exclusion Criteria:
- Patient who would have difficulty participating in a trial due to non-adherence or substance abuse
- Patient who is pregnant or breast-feeding
- Patient with a malignancy receiving systemic chemotherapy
- Patient with end stage organ disease
- Patient with other significant non-HIV underlying disease that might impinge upon disease progression or death
- Patient who is not taking standard dosing of a PI or NNRTI as listed in Appendix G
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00433979
Please refer to this study by its ClinicalTrials.gov identifier: NCT00433979
|Canada, British Columbia
|Children and Women's Hospital
|Vancouver, British Columbia, Canada, V6H 3N1
|St. Paul's Hospital
|Vancouver, British Columbia, Canada, V6Z 1Y6
|Downtown Infectious Diseases Clinic
|Vancouver, British Columbia, Canada, V6Z 2C7
|Canada, Nova Scotia
|Capital District Health Authority
|Halifax, Nova Scotia, Canada, B3H 1V7
|Canada, Ontario
|Hamilton Health Sciences - McMaster University
|Hamilton, Ontario, Canada, L8N 3Z5
|University of Ottawa Health Services
|Ottawa, Ontario, Canada, K1N 6N5
|Ottawa Health Research Institute
|Ottawa, Ontario, Canada, K1Y 4E9
|Sunnybrook Health Sciences Centre
|Toronto, Ontario, Canada, M4N 3M5
|Canadian Immunodeficiency Research Collaborative
|Toronto, Ontario, Canada, M5B 1L6
|St. Michael's Hospital
|Toronto, Ontario, Canada, M5B 1W8
|University Health Network - Toronto General Hospital
|Toronto, Ontario, Canada, M5G 2N2
|Windsor Regional Hospital HIV Care Program
|Windsor, Ontario, Canada, N8W 1E3
|Canada, Quebec
|Centre de recherche du Centre hospitalier de l'Universite de Montreal (CHUM)
|Montreal, Quebec, Canada, H2W 1T7
|Montreal Chest Institute
|Montreal, Quebec, Canada, H2X 2P4
|Quebec, Canada, G1V 4G2
Sponsors and Collaborators
Women's College Hospital
Canadian Institutes of Health Research (CIHR)
|Principal Investigator:
|Mona R Loutfy, MD FRCPC MPH
|Women's College Hospital
More Information
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Women's College Hospital:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Loutfy MR, Walmsley SL, Klein MB, Raboud J, Tseng AL, Blitz SL, Pick N, Conway B, Angel JB, Rachlis AR, Gough K, Cohen J, Haase D, Burdge D, Smaill FM, de Pokomandy A, Loemba H, Trottier S, la Porte CJ. Factors affecting antiretroviral pharmacokinetics in HIV-infected women with virologic suppression on combination antiretroviral therapy: a cross-sectional study. BMC Infect Dis. 2013 Jun 3;13:256. doi: 10.1186/1471-2334-13-256.
|Responsible Party:
|Dr. Mona Loutfy, Women's College Research Institute
|ClinicalTrials.gov Identifier:
|NCT00433979 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 9, 2007
|Last Updated:
|July 27, 2012
Keywords provided by Women's College Hospital:
Anti-HIV agents
Physiological Effects of Drugs
ARV-associated Adverse Events
Protease Inhibitors
Non-nucleoside Reverse Transcriptase Inhibitors
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


text:
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Suspect arrested in beating, robbery at Cape Coral McDonald's
A suspect has been arrested in a beating and robbery of a person at a Cape Coral McDonald's. Police said the incident happened Sept. 14 in the parking lot of the McDonald's at 8 NE Pine Island Rd. Hector Torres Jr. beat a man and took his wallet and cell phone, according to police, who also said Torres knew the victim. He's been charged with robbery without a weapon and battery. He remains in the Lee County Jail on $10,000 bond. Copyright 2017 WBBH/WZVN (Waterman Broadcastin...
Lee commish pleads not guilty to DUI charges
The attorney for the Lee County commissioner involved in last week's DUI crash in Cape Coral filed a not guilty plea for his client.


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Persons of InterestRebus brain teasers use words or letters in interesting orientations to represent common phrases.
What is the meaning of this rebus?
marcus Brutus
john wilkes Booth
Billy the kid
Bonnie parker
clyde Barrow
AnswerKiller Bees (these people are all murderers, and each has "B" for an initial)
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Volleyball TournamentMath brain teasers require computations to solve.
During the recent volleyball tournament, 5 schools were competing. Each school played each other once (single round robin format), with 4 points for a win, 2 points for a draw, 0 points if they lost. Here are the final points after all of the matches:
UC Davis--12
Sonoma St--10
Sac St--8
Chico St--4
Cal Poly ==?==
How many points did Cal Poly end the season with?
Answer6 points; in a single round robin format five teams will play a total of 10 matches. With ten matches 40 points were possible. The other team points add up to 34; Cal Poly must have 6 points to take the total to 40
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Louisiana's unemployment rate fell to 4.5 percent in February, hitting the lowest level since mid-2008.
The number of people who told surveyors they had a job hit a new record for the fifth month in a row, approaching 2 million.
A separate survey shows payrolls were grew slightly from January to February, but remained below the record levels of late 2013.
Both sets of figures – adjusted to cancel out normal seasonal changes – were released Friday by the U.S. Department of Labor.
Louisiana's unemployment rate was 4.9 percent in January and 6.4 percent in February 2013.
Total unemployed Louisianians fell below 100,000 – also for the first time since mid-2008 – hitting 95,000 in February. That's down from almost 103,000 in January and 134,000 in February 2013.


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Boiling water is easy as one, two, three, four
Theres more to boiler level control than measuring level and adjusting a feedwater valve. Improved measurements and inverse response are just a few of the influences on operating boilers in a reliable manner.
AN ANALYSIS of boiler level controls shows the importance of the interrelationships between the process, measurement instruments, and control strategy used to achieve the control objective. In short, the boiler burns fuel to convert water into steam, and makeup water is added to replace the steam (water) that leaves it.
Harold Wade suggests a few additional points be made to the three-element boiler level control figures in this article.
Operating at a high water level in the boiler can carryover water into the steam header. Operating the water level too low can damage the boiler. Neither of these conditions is desirable, so the boiler should be operated so its water level is such that neither the high nor low-level switches shut it down. The overall control objective is to replace the water that leaves the boiler in such a way that its water level remains constant.
A single-element boiler control strategy (See Figure 1 below) achieves this objective by measuring boiler level, and using a controller to manipulate the makeup water feed valve. Consequently, increasing steam demand causes more steam to leave the boiler, which lowers the water level in the boiler. The controller senses the low level (feedback), and reacts by increasing the makeup water flow to increase the level to its setpoint.
A single-element strategy keeps a boiler's water level constant by measuring level, and using a controller to manipulate the makeup water feed valve.
The nature of this control strategy is such that changes in the makeup water flow are initiated when the boiler level isn't at its setpoint. Because makeup water flow will vary with demand and firing rate, the boiler level will deviate from its setpoint during normal operation. This strategy may be adequate for many boilers, especially in applications where steam demand is constant or varies slowly.
Complicating the issue is the transient inverse response of the water level in the boiler. When more fuel is burned, the water's temperature increases and it expands, thereby raising its level. On the other hand, more water is boiled when more fuel is burned, thereby lowering the level. In actual operation, the boiler level initially increases in response to expansion followed by a drop in level due to the loss of water. Therefore, the level controller can react incorrectly to a fuel increase by initially reducing makeup water flow in response to the increasing level measurement. More sophisticated controls may be necessary to compensate for this effect.
For instance, implementing a two-element boiler control strategy by adding a cascade-makeup, water-flow control loop to the boiler level control (See Figure 2 below) can improve control by reducing level variations from setpoint and makeup water flow fluctuation. This strategy cuts the effect of disturbances in the flow loop, and allows the level loop to be tuned for better performance.
A two-element strategy adds a cascade-makeup, water-flow control loop to improve control by reducing level variations from setpoint and makeup water flow fluctuation. This cuts the effect of disturbances in the flow loop, and allows the level loop to be tuned for better performance.
To reduce the effect of changing steam demand on boiler level, a three-element boiler control strategy can be used (See Figure 3 below). In this strategy, steam flow from the boiler is measured, and used to adjust the output of the level controller, so that a change in steam flow results in a like change in makeup water flow. This control strategy operates as feed-forward because it manipulates the makeup flow before the boiler level has time to change.
In three-element boiler control, steam flow from the boiler is measured, and used to adjust the output of the level controller, so a change in steam flow results in a like change in makeup water flow.
Finally, four-element boiler level control (See Figure 4 below) can be implemented by taking boiler blowdown into account.
Four-element boiler level control is implemented by taking boiler blowdown into account.
Greg Shinskey, a process control consultant from North Sandwich, N.H., says, "The magnitude of shrink-swell (inverse response) varies with the type of steam generator. In nuclear power plants, pressurized water reactors exhibit much more shrink-swell compared to boiling water reactors where large volumes of water surround the nuclear fuel." He suggests using a non-linear filter in the controller to let the feed-forward do most of the work in pressurized water reactors (see "Taming the Shrink-Swell Dragon," March '04).
Fossil fuel boiler designs are more similar, so shrink-swell varies with the density difference between the water and steam. In higher pressure boilers, the density difference is less than in lower pressure boilers. Therefore, boilers operating at higher pressures generally exhibit less shrink-swell than lower pressure ones.
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2 = M A by J CLetter Equations are well known phrases or facts where the key words have been replaced with the first letter of that word. These are often in the form of an equation, which contain a number, an = sign and the rest of the obscured phrase or fact.
2 = M A by J C
HintThink Romans
Answer2 = Months Added by Julius Caesar.
When they discovered that their calendar year was shorter than a proper year, Julius Caesar added two extra months to lengthen the year. They were July - named after himself - and August - named after his heir, Augustus.
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Yummy Earth Organic Fruit Lollipops (3 oz. bag)
Quantity in Basket:
Code: YummyEarth
Shipping Weight: 0.00 pounds
YUMMY EARTH ORGANIC FRUIT LOLLIPOPS (3 oz. bag)
Each bag of these all-natural, Certified Organic
fruit lollipops contains an assortment of flavors,
including Mango Tango, Pomegranate Pucker,
Tooberry Blueberry, and Wet-Face Watermelon. Gluten-free.
14 individually wrapped pops per bag -- each
has just 22 calories. Phil Lempert, food editor
for the TODAY Show, called it
"the best lollipop I've ever tasted."
Ingredients: Organic evaporated cane juice, organic tapioca syrup, and/or organic rice syrup, citric acid (from beet sugar), natural flavors, may contain organic black carrots, organic black currant, organic apple, organic carrot, organic pumpkin.


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Nielsen: Building Brands in a Cross-Platform World
December 6, 2011
In this research report, Nielsen provides insights on how cross-platform reach and frequency metrics and cross-platform ad effectiveness optimization approaches are possible.
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POMONA — A LifeStream community blood drive will be held Wednesday at North West College, 134 W. Holt Ave.
The drive will be from 11 a.m. to 4 p.m.
Those aged 18-44 years may register for Be The Match bone marrow screening free of charge.
All prospective donors should be free of infections or illness, weigh at least 110 pounds, and not be at risk for AIDS or hepatitis.
Information: 800-TRY GIVING.


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The stretches of brilliance obscured by the disasters don't matter at present.
Sure, those moments where the Chargers have looked like a really good team the past two games could one day prove to have been foreshadowing. But so far in this season in which the onus is on the Chargers to show they are different, all they've shown is that they have a glass jaw.
So, as of now, I'm not sure what would make me believe my guy won't be gone at season's end. I have little reason to be confident I won't be proved wrong, that it will turn out Norv Turner can't win a championship with the Chargers after all.
I was resigned to that even before I talked to A.J. Smith Tuesday afternoon. And then, well, catch Smith in a mood and it really gets interesting.
"We have some outstanding, talented players on this team and some outstanding coaches across the board," the Chargers general manager said. "But obviously we cannot play as a team. We appear to not be able to handle adversity or finish games. Individual and team confidence appears to be going south."
To my thinking, those words could hardly have been more damning had Smith actually stated that Turner was on the plank.
Smith would not state that, by the way.
Using as an entree Tuesday morning's news that Philadelphia Eagles Head Coach Andy Reid, who makes the football decisions in that organization, had fired his defensive coordinator, I asked Smith if it were possible Turner or any other coaches could be jettisoned during the bye week. (I knew it wouldn't happen, but I had to ask.)
"We have 10 games left and are tied for first place," Smith said. "No matter how low we may feel at the moment, we will rest up and get ready to find a way to win the Cleveland game. That's the only thing that matters right now."
Smith actually expressed confidence.
"Can we flip the funk we find ourselves in?" he said. "Absolutely we can. With the bunch we have in our locker room, that's what I expect to happen."
Of course he would think so.
Barring a total collapse, I believe Chargers President Dean Spanos intends to keep Smith after this season.
But let's be real about that.
One of the emphases by Smith this past offseason was to bring in veterans of such ability and character that they would be able to prevent prolonged in-game and in-season slumps.
If those players can't conspire to stem this hemorrhage, then what does that say about the job Smith did? It says he didn't do a good one.
"I take full responsibility for the present mess this team is in at this point in time," Smith said. "The construction and direction of this organization is on my watch. In the next 10 games we will either rally and see a slow, steady rise from the ashes to a division championship – or the beginning of a new era in Chargers' football."
Believe that.
I know Spanos was appalled that his team could allow the New Orleans Saints three fourth-quarter scores on Oct. 7. And what happened Monday night made that look like nothing.
The drubbing by the Denver Broncos was historic. The Chargers led 24-0 at halftime and lost 35-24, as Denver became the first team in NFL history to have faced such a deficit and come back to win by double digits.
Even given to the whims of an owner who thinks highly of him and granted him a reprieve following last season, Turner can't survive those kind of collapses.
Spanos blew by me on Tuesday en route to a meeting looking as angry as I've ever seen him. I said, "How're you doing?" He didn't slow down as he replied, "I've been better." Perhaps he just got word he didn't save 15 percent on his car insurance after all. But I doubt it.
I think it had more to do with him sharing in his G.M.'s assessment of the state of the team.
"It was an embarrassing and humiliating performance by a team going in the wrong direction fast," Smith said. "We played a team that's coming together fast and building confidence. Peyton Manning had one of the greatest second-half performances I've ever seen in my time in the league … We have dropped three out our last four games (and lost) on back-to-back national broadcasts. We are about as low as a team can get right now and going into the longest bye we will ever experience."
Dean Spanos doesn't fire people easily and certainly doesn't do so without much deliberation and until all the information is in.
This team doesn't stop melting away its promise, though, and his decision this time is inevitable.


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I'm a rabid reality-TV hater but I make an exception for "Deadliest Catch" and I have to admit, my wife and I are hooked on "Biggest Loser."
I don't really get the love for "Big Bang Theory." I think it's ok but the only funny thing about it to me is the Sheldon character. Reminds me a bit of "All in the Family" in that if it was a non-Archie episode, it was brutal to watch.


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From the mangrove forests of Bangladesh to your child's bedroom, this adorable tiger humidifier is perfect for any youngster. The kid-friendly design will keep them smiling while the humidifier allows them to breathe more comfortably, and the quiet ultrasonic humidification system won't wake them at night. The one-gallon tank provides 2.1 gallons of moisture output per day and it automatically shuts off once it's empty.
Product Specifications:
Features and Benefits: