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Efficacy of Treatment Intensification With Maraviroc on HIV-1 Viral Latency in Recently Infected Hiv-1 naïve Patients Starting Raltegravir Plus Tenofovir/Emtricitabine
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The intensification with maraviroc in recently HIV-1-infected patients of a preferred gold-standard triple therapy composed of raltegravir plus tenofovir/emtricitabine could accelerate the decay of the HIV-1 reservoir in latently infected cells established early in HIV-1 infection.
This could provide further insight into this area, decrease the size of latent reservoir, and translate into clinical benefits for patients.
|HIV Infections
|Drug: Raltegravir Drug: Maraviroc Drug: Tenofovir/Emtricitabine
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Efficacy of Treatment Intensification With Maraviroc on HIV-1 Viral Latency in Recently Infected Hiv-1 naïve Patients Starting Raltegravir Plus Tenofovir/Emtricitabine.
- Change at 48 weeks in the slope of decay of integrated and unintegrated viral DNA in PBMCs. [ Time Frame: BL, W2, W4, W12, W24, W48 ]
- Decay of residual HIV-1 replication under maraviroc intensification assessed by an ultrasensitive RT-PCR assay with a lower limit of quantification of 5 copies/mL. [ Time Frame: BL, W2, W4, W8, W12, W24, W36, W48 ]
- Blips during the study (viral load >50 copies/mL, preceded and followed by determinations <50 copies/mL in previous and posterior controls). [ Time Frame: From Baseline to W48 ]
- HIV-1 RNA below 50 copies/mL at 48 weeks. [ Time Frame: W48 ]
- Change in the lymphocyte activation marker HLADR+CD38+ from baseline to week 48. [ Time Frame: BL, W4, W12, W24, W48, W60, W72 ]
- Relationship between maraviroc and/or raltegravir plasma concentrations and change in the slope of decay of integrated viral DNA in PBMCs [ Time Frame: W12, W24, W48 ]
- HIV-1 specific CTL responses [ Time Frame: BL, W24, W48, W60, W72 ]
- Plasmatic inflammation biomarkers [ Time Frame: BL, W2, W4, W12, W48, W60 ]
- RNA, DNA and viral p24 associated to cells in ileum biopsy and PBMC [ Time Frame: W48 ]
- Lymphocyte activation marker HLADR+CD38+ in ileum biopsy and PBMC [ Time Frame: W48 ]
- Fibrosis markers in ileum biopsy and PBMC [ Time Frame: W48 ]
|Study Start Date:
|February 2009
|Study Completion Date:
|November 2011
|Primary Completion Date:
|November 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
From Baseline to Week48: Raltegravir BID + Tenofovir/Emtricitabine QD + Maraviroc BID From W48 to W72: Raltegravir BID + Tenofovir/Emtricitabine QD
Drug: Raltegravir
Raltegravir 400 mg every 12 hoursDrug: Maraviroc
Maraviroc 300 mg every 12 hoursDrug: Tenofovir/Emtricitabine
Tenofovir/Emtricitabine 300/200 mg every 24 hours
Active Comparator: 2
Start ARV treatment with : Raltegravir BID + Tenofovir/Emtricitabine
Drug: Raltegravir
Raltegravir 400 mg every 12 hoursDrug: Tenofovir/Emtricitabine
Tenofovir/Emtricitabine 300/200 mg every 24 hours
Detailed Description:
A reservoir of latently infected cells established early in infection may be involved in the maintenance of viral persistence despite continuous highly active antiretroviral therapy (HAART). This is likely to represent the major barrier to virus eradication in patients on successful combination antiretroviral therapy.
The majority of the viruses in the latent reservoir use CCR5 receptor during entry.
More recently, clear evidences for decay of this HIV-1 reservoir in patients who initiated antiretroviral therapy early in infection have been demonstrated. The treatment of acute infection may set the stage for subsequent attempts at eradication. To achieve this, more potent antiretroviral therapy and/or more potent antilatency therapies may be needed.
In contrast to previous antiretroviral drugs, maraviroc does not need to cross the cell membrane, nor does not require intracellular processing in order to exert its activity. In addition, there is no cross-resistance between entry inhibitors and agents that act on intracellular targets.
Maraviroc has demonstrated potent antiviral activity against all CCR5-tropic HIV-1 viruses tested. Maraviroc could thus fulfil the requirements for an optimal candidate for treatment intensification in HIV-1 infected patients with a recent HIV-1 infection.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV-1 infected adults (>=18 years old).
- No previous antiretroviral therapy for more than 2 weeks.
- HIV-1 infection documented in the past 6 months by a previous negative ELISA test, or a documented clinical acute seroconversion in the past 6 months.
- CCR5-tropism confirmed at screening.
- Voluntary written informed consent.
Exclusion Criteria:
- Pregnancy or fertile women willing to be pregnant.
- Active substance abuse or major psychiatric disease.
- Presence of NRTI mutations in the screening genotype.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00808002
|Hospital Germans Trias i Pujol
|Badalona, Barcelona, Spain, 08916
|Hospital Clinic i Provincial de Barcelona
|Barcelona, Spain, 08916
|Principal Investigator:
|Bonaventura Clotet, MD,PhD
|LLuita contra la SIDA Foundation-HIV Unit
|Principal Investigator:
|Josep Mª Llibre, MD,PhD
|LLuita contra la SIDA Foundation-HIV Unit
|Responsible Party:
|Dr . BONAVENTURA CLOTET, Dr. Bonaventura Clotet, Germans Trias i Pujol Hospital
|ClinicalTrials.gov Identifier:
|NCT00808002 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 12, 2008
|Last Updated:
|September 5, 2014
Keywords provided by Dr . BONAVENTURA CLOTET, Germans Trias i Pujol Hospital:
CCR5 antagonists
Primary HIV Infection
HIV-1 reservoir
treatment naive
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Raltegravir Potassium
Antiviral Agents
Anti-Infective Agents
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Anti-HIV Agents
HIV Integrase Inhibitors
Integrase Inhibitors
CCR5 Receptor Antagonists
ClinicalTrials.gov processed this record on September 21, 2017


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Lead Line
— August 2001
By Richard Thiel
Power from Down Under
|The Aussies and Kiwis have enjoyed success.
Quick, name a continent that exports powerboats to the United States. Bet you said Europe, and no wonder. Builders from Italy, Great Britain, Germany, Holland, and France have made foreign boats not only acceptable, but also desirable over here.
Now name another exporting continent. You probably guessed Asia, thanks to yards like Cheoy Lee and Grand Banks. But farther south is an area that has been quietly sending pleasureboats to our shores for decades and is about to do so with considerable more fanfare: Australia and New Zealand. Everyone knows about their boat-designing and building prowess, thanks to their success in the America's Cup. Both are also widely admired for the fuel-efficient power catamarans that have been showing up since the early '80s. But after visiting Australia's Sanctuary Cove Boat Show last May, I discovered that both countries are also building high-quality, mainstream production boats–targeted at you.
The Aussies and Kiwis have already enjoyed success, and little wonder. They do things differently in the antipodes. Take the Sanctuary Cove Boat Show. Instead of the typical sprawling U.S. and European versions, it's free, of a manageable scale, and nestled among waterfront hotels, shops, and restaurants, a highly civilized concept that invites leisurely perusing interspersed with a glass of wine, a bite of real food, and maybe a souvenir.
Among the boats I boarded there, the dominant name was Riviera, Australia's largest yard and a major exporter to the United States with convertibles ranging from 30 to 56 feet. (Some 40 percent of its production comes here, either under its own brand or that of Wellcraft.) I already knew about Riviera from this year's PMY project boat, a 40 Convertible. Riviera's ads tout that its boats come from a country beset by two oceans and four seas, a fact that explains Office Ours' solidity and strength. More surprising was my trip to the Riviera factory, just down the road from the show, where I saw one of the cleanest, best organized, most efficient plants anywhere.
Riviera may be the 400-pound gorilla, but it's not the only player. I saw a striking 38-foot Express Cruiser from Mustang Cruisers, which also has a 46-footer underway and is exporting boats to the West Coast. Steber showed off a businesslike 52-foot Express Motor Cruiser, and Australian Motor Yachts announced construction of a high-speed aluminum 162-footer designed by Don Shead, to follow its 145-foot Silver Fox, delivered last year to an American. At the slower end of the spectrum was a world-capable, single-engine, all-steel, displacement 80-footer from Voyager, an Australian company building boats in Vietnam.
The Kiwis are just as aggressive. Their most impressive offering was a 65-foot convertible from Salthouse Marine, built like a tank, finished like a boardroom, and bristling with innovations like a two-piece sliding transom door. Look for a boat test this fall. Formula Cruisers displayed two highly engineered and nicely finished convertibles, a 54 and a 40, while Warwick Yacht Design unveiled a 90-foot catamaran sportfisherman with a reported top speed of 35 knots.
There were others, too many to list, and most representatives said they were either already in the American market or looking to establish a presence here. That shouldn't be too hard, since the boats I saw were all superbly engineered and built and both the Aussie and Kiwi currencies had recently hit all-time lows against the dollar, making (in theory, at least) both countries' boats attractively priced for U.S. buyers.
Both Australia and New Zealand are aggressively targeting the United States with boats that are really different. In fact, I'll bet that in a couple of years, when someone asks you to name an area exporting pleasureboats to America, Australia and New Zealand will be on the tip of your tongue.
This article originally appeared in the January 2003 issue of Power & Motoryacht magazine.

subset: commoncrawl


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|Stan teaching the Naivasha class
|Cliff teaching the Naivasha class
|The men walking to class
|Stan teaching the Naivasha class
|Cliff teaching the Naivasha class
|The men walking to class
Posted by CROSSROADS AFRICA EXPEDITIONS at 1:28 PM
"KARIBU" - Welcome
As missionaries we consider cross-cultural missions to be a thrilling expedition, full of challenges and discoveries. Our travels take us to some amazing places and people.
As we leave our "base camp" we are blessed to 'forge streams' of new relationships and 'climb mountains' with those who survive solely on hope. It's a wonderful adventure. Please join us.
For this cause I bow my knees unto the Father of our Lord Jesus Christ, of whom the whole family in heaven and earth is named. That he would grant you, according to the riches of his glory, to be strengthened with might by his Spirit in the inner man. Ephesians 3:14-16, the apostle Paul
"Twenty years from now you will be more disappointed by the things you didn't do than by the ones you did do. So throw off the bowlines, sail away from the safe harbor. Catch the trade winds in your sails. Explore. Dream. Discover." – Mark Twain
Crossroads Explorers,
Cliff, Stan, Dan, Paula
Actor Hugh Jackman of the X-Men and Australia stepped in to record a special introduction to the film Moja Moja for the final days of the Borderlines Film Festival. Moja Moja, made by former Hereford Art School¹s Sam Oliver, and featuring children at a Kenyan orphanage, was given a charity screening at the Festival. Sam flew home from filming in Mexico to introduce his film: ³We re-edited the film for Borderlines after Hugh agreed to add his special introduction for the Festival.² Jackman¹s intervention has helped raise $100,000 for the orphanage said Sam who presented Moja Moja at The Courtyard where, ten years ago, he once worked as one of the projectionists.


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Introduce your K-4 students to Earth Systems Science using the weather, hydrology, phenology, and soils modules.
Climate smart lesson plans, resources, videos and learning opportunities corresponding to the science and issues presented in the series.
From award winning author and illustrator, Lynne Cherry, whose books include A River Ran Wild and The Great Kapok Tree, comes a film series featuring young people who are making a difference. Speaking Out. Creating Solutions. Leading the Change.
Learn more>>
Show your students how climate change is impacting our planet.
Take EPA's climate expedition, calculate your emissions, and be a part of the solution! Check out their website:


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This is the story of William Shatner's half-century career and private life. The audio will take listeners from the streets of Montreal to regional theater, where Shatner was once called upon to replace Christopher Plummer as Henry V— in a role he had never rehearsed, with actors he had never met. It will describe his early TV work and movies, among them Roger Corman's The Intruder, a movie about racism filmed in the south in 1961; Kingdom of the Spiders, in which he costarred with 30,000 tarantulas; and Incubus, the only film ever made in the language of Esperanto. It will include his private life, including the complete story of the drowning death of his third wife. It will include stories from three other series: T.J. Hooker, Rescue 911—which saved more than 240 lives—and Boston Legal, as well as his work on Third Rock from the Sun, for which he won his first Emmy for playing "the Big Giant Head".
And, of course, it will include the story of Star Trek: how it came about and how it affected him—and fans—concluding with the story of a taxi driver who told Shatner he'd been a prisoner in Vietnam and that pretending they were the Star Trek crew kept him and his fellow inmates sane. And yes, it will include his singing and commercials and quiz-show hosting and award-show hosting and the greatest practical joke ever played, Invasion, Iowa, not to mention the story about Shatner being invited into a cage with Koko the Gorilla—who wanted to take him back to her bedcage.
After almost 60 years, William Shatner has become one of our most beloved entertainers. And as evidenced by Comedy Central's roast, The Shat Hits the Fan, Shatner gets the joke. For the first time, William Shatner shares with listeners the remarkable, full story of his life.
©2008 William Shatner and David Fisher (P)2008 Macmillan Audio
"Outstanding narration"
Bill Shatner should narrate more books. He is very entertaining, keeps the listening very interesting, and is able to poke fun at himself. The years must have put some humility into him. I think history will treat Bill better than the present. A must read if you have ever been entertained by watching anything he has had a part in.
"Definately worth a listen ..."
Really entertaining read. Enjoyed every minute. My ONLY negative criticism would be that Shatner's extremely well known speech cadence sometimes gets in the way of actually HEARING the story. On headphones it's fine ... in the car, it's necessary to mess with the volume knob all the time. Other than that ... I loved it and am still amazed at the life he's led.
"What a Delight!"
I loved hearing William share his own stories. It was enjoyable from beginning to end. He is a treasure - I love his spirit! So personable - so human. You will feel like you really know him when you're finished.
I have yet to hear another autobiography I liked more.
Hearing his voice, his humor and every inflection. No one could tell his story better than him.
His wife's tragic drowning in the pool. So sad and moving. I felt his pain. I could envision every detail he described. I appreciated his honesty. What a humble man.
"Hang on for a great listen"
Bill Shatner is going full speed the entire book and it is one hilarious and entertaining story after another. I can't imagine this book being half as good if you had to just read it. The stories by themselves are funny and entertaining but listening to Shatner act the dialogue makes you feel as if he is telling the stories to you personally and you are experiencing much of his life as he has lived it. A really fun book.
Blind Vietnam veteran. Antique weapons collector. Outdoor enthusiast. Florida State University graduate with Business major. Owner of home health agency. registered nurse.
"Wanna Meet the Real Captain Kirk?"
Shatner does a fine job of telling his own story and introducing the real Captain Kirk to the listener. I thoroughly enjoyed the book and the comments and have decided that I like Shatner better than I liked Kirk.
"Honest, Humble and Fabulous Fun"
William Shatner is amazingly open and forthcoming in this book. His self-deprecating humor is engaging. His honest and humble story-telling reminds us that we all have different perspectives and that doesn't make us wrong, it just makes us unique.And his story-telling is engaging. His voice draws you in to his world and makes you an empathetic friend. I felt like I was just hanging out with my new friend at Starbucks.
The alien in the desert.
My Life on Earth
"I loved this book."
Not only is it an autobiography, but it's read by Bill himself ! You get to hear Bill tell you about his long career and his ups and downs along the way. His humor blends the whole thing together in a very unexpected and brilliant way. I found myself cheering for him in his retelling of winning the Emmy, and tearing up when he spoke of his late wife .I loved this book from the first chapter to the funny last sentence!
Life is an Adventure
"Great Story Teller!!!"
He kept me interested in the book from the very beginning of the book! He know how to tell a good story! He has also an entertaining voice to keep you interested in the book. Worth
His story telling skills
Take every opportunity that comes to you
Worth listening to!
A creative writer & a lover of Macs, gadgets, and women.
"An excellent autobiography."
Shatner's performance is really remarkably enjoyable. Unlike many of his other narrations, this one holds my interest again and again with its liveliness alone.
Bill of course!
Yes, I have, and this one is the best of the lot, by far.
Laugh, a LOT.
I listened to the abridged version before buying this one. I bought this unabridged version because I was hoping there would be more of the same excellent material, and I was not disappointed. However, if you already have the abridged copy, you're not missing out on enough to warrant the cost of purchasing this unabridged version. I can't think of anything specific that was left out of the abridged edition. Really, this edition is primarily for those who can't get enough of Bill Shatner...like myself! :)
"Funny but uneven"
Never read the book, though due to the audio issues it may have been a bettter choice.
I thought the book was very funny in parts and that no one else except William Shatner could have read it. My only criticism (though it is a big one) was the extreme volume fluctuations. While knowing that some of it is due to Shatner's delivery from "normal volume" speaking down to below a whisper, it was very difficult to listen to without having to constantly turn the volume up and down. Just when you thought you had reached a balance, it would go really loud or almost silent again. The content of the book was good and as this was my first book from William Shatner I was pleased with all the meandering and side stories, etc that he would inject, I just wish it could have been a better audio experience.
Again the audio production made it very difficult to enjoy as much as it could have been.
"my thoughts"
loved it, but it points when a low voice had difficulty hearing especially in car
"True classic Shatner"
good read. revealing and insightful.
please read on. highly recommended. the story of a great actors life and good to get the t tg ue story about the whole star trek era. and much more
"Very entertaining and honest"
I love biographies and am a fan of William Shatner so this was a great fit. It's read by the author. I found it to be very entertaining and fun. I enjoyed listening to it and thought the author was very honest. He has had an amazing career and I enjoyed listening to the story about it.
"Loved this book"
Yes, Interesting, Funny and a little sad
The death of his beloved wife
William Shatner talking about Danny Crane
It was lovely to have a book make me laugh out loud
"A must Read"
I have been a a life long fan of William Shatner so this was a must read for me . Full of an actors experiences of life . Failure, triumph , dispare, sadness and happines .
Particularly liked the humour and having it read to me by the man himself . Awesome man.
"Genuine and enjoyable thanks Bill"
I had already listened to Leonard before this and although some stories do repeat in this volume I enjoyed them second time round too
Mr Shatner comes across as a genuine and sometimes frustrating human being but that said no one can match his work ethic even now still offering us Boston Legal to name one and I would recommend this title to anyone wanting to delve deeper into the "Shatman" and leave behind the whole Star Trek ethos and just enjoy the ride that is Bill .
"I love William Shatner."
Great book. I love hearing Bill tell me his story. I hope he lives forever.
"Charm wins out"
There are more interesting and better written autobiographies but this is not a bad example and the charm, ego and self awareness of Shatner made it an entertaining listen from beginning to end for me.
In the opening words this book had me laughing
There is sadness and lots of laughs
A good listen which I will listen to again at some point
"Mr Shatner is a very engaging companion"
Mr Shatner is at all times honest in his assessment of his life. And is unafraid of critisising himself which makes this a refreshing read.
This is going to seem odd. But bear with me. Clarissa Dickson wright's Spilling the Beans"!Because she too doesn't pull any punches and it's a great read too.
It sounds as if he is talking just to you and as if he's known you all your life
Made me laugh. And it is sad in parts
Even if your not a Star Trek fan or your not fan of Mr Shatner give this a go. It's well worth the effort.
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Willits artist and photographer Ree Slocum has become hooked on the unique opportunities and effects offered by one of the newest and quickest growing photographic techniques, iPhoneography. She brings some of her latest creations to a show this month at Blue Sky Gallery. The show, named "Metal," opens Saturday, December 1, with an artist's reception at the gallery from 7 to 9 p.m.
iPhonography first appeared on the photographic scene about four years ago and has exploded with the proliferation of iPhones. Professional photographers, such as Slocum, became attracted to the genre as the quality of the iPhone camera increased and the range and capability of new apps expanded.
While Slocum has not given up her high-end camera, she has embraced this new genre as one way to extend her artistic talents into new areas.
"This is more art than photography," says Slocum. "It is on the edge of what people are doing today with photography."
Her new show, Metal, began as a photo shoot about the retrieval and dismantling of a Lidgerwood tower skidder in Tacoma, Washington, by the Roots of Motive Power crew. During breaks in the action, Slocum became fascinated by the old bolts, rivets and the patina of rust on this 300-ton ancient behemoth of the forest. The Lidgerwood skidder is thought to be the last of its kind.
Using her iPhone she began taking pictures of different aspects of the machine, sometimes riding up in the man lift to get a particularly interesting shot.
Slocum took a series of images and has compiled nearly 40 of her best metal shots for the upcoming gallery show. She used a variety of apps to achieve the combination of color, mood and tone she wanted for each one.
The show features a combination of fully matted photos and picture cubes.


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SANTA CRUZ -- Settlement discussions continued Monday in a case involving alleged labor violations at the Brookdale Inn and Spa.
Oswaldo Cabello Martinez sued the business' owners, Sanjiv and Neelam Kakkar, in April 2010. Martinez had worked for the Kakkars from September 2007 to August 2009, performing maintenance, repairs and numerous other tasks, according to his suit.
In court filings, Martinez alleged he was barely was given enough money to afford meals and wasn't given the tools he needed to perform the work required of him. He said he had to spend the little money he had on tools, he was paid with checks that bounced, and he wasn't permitted to take rest breaks every four hours or meal breaks every five hours, as required by law.
Furthermore, Martinez claimed he was made to work in unsafe conditions and was assaulted by a man staying at the Brookdale Inn's apartments. He said he was fired when the injuries he suffered left him unable to perform certain tasks, according to the complaint.
A court trial originally was scheduled for Monday but instead, Santa Cruz County Judge John Gallagher presided over settlement discussions between the parties. The Kakkars, represented by attorney Anna DiBenedetto, were present along with Martinez, a Spanish interpreter and Tomas Margain, a Bay Area attorney who specializes in labor issues. Negotiations still were continuing late Monday afternoon.
The Kakkars also are involved in an unrelated criminal case in which they're accused of committing workers' compensation fraud. Santa Cruz County District Attorney Kelly Walker has accused the couple of providing conflicting wage information to obtain lower insurance premiums. Walker has said the couple paid about $800,000 less in insurance premiums than they should have. Trial is set for April 8.
Last year, a Santa Cruz County judge appointed a receiver for the Brookdale Inn and Spa after an ongoing legal dispute with county officials involving building code violations.
The Kakkars purchased the historic building in 2007 but it has been shuttered for more than a year for numerous fire code violations that went uncorrected.
Follow Sentinel reporter Jessica M. Pasko on Twitter at Twitter.com/jmpasko96


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Frank Delicious wrote:discspeed wrote:Put Katana back in...I tried to replace it with the Pro Boss...but that disc just couldn't do what the Katana does.
What did the pro boss lack for you? I put a champ katana back in after messing with a beat pro boss and what got me to put the katana back in was the difference in lss, even my beat pro boss would hyzer out and skip more than the katana for me.
Yes. The LSS, cruising speed, and squirreliness.


text:
Bloody V-neck T-shirt s are an Idakoos specialtiy! Idakoos has many things to offer. Whether you want to get a Bloody V-neck Tee for a special occasion, give a Bloody T-Shirt as a present or need to represent with a funny Bloody V-neck Tee during Holidays or Family and Friends get-togethers, Idakoos is sure to have the right Bloody V-neck T-shirt for you! Even if it turns out you can't find the right Bloody V-neck Shirt with the perfect design for your mother, father or children; Idakoos offers all of its men's women's and children's Bloody V-neck T-shirt s as Custom Bloody T-Shirts. Personalize any Bloody V-neck T-shirt the way you want to ensure the perfect gift.
Showing 1 - 24 of 68 V-Neck T-Shirt


text:
2005 Pacific Skiffs Inc Values, Specs and Prices
Select a 2005 Pacific Skiffs Inc Model
(2014 - 1995)
A Maryville, Washington boat builder originally founded as Pacific Manufacturing Incorporated, Pacific Skiff Incorporated serves both commercial and recreational activities. Since 1986, Pacific Skiff Incorporated has worked at developing all-welded aluminum boats suited for various purposes including fishing, shrimping, diving and even oil spill response. From 17 to 28 feet in length, the vessels created by Pacific Skiff Incorporated predominantly features outboard motor power. Pacific Skiff Incorporated products have been created for discriminating customers that includes the United States Navy.


text:
Lopinavir/Ritonavir (Kaletra) PK in Children
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|HIV/AIDS Treatment HIV Infections
|Drug: lopinavir/ritonavir (Kaletra®) tablets
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Pharmacokinetics of Lopinavir Crushed Versus Whole Tablets in Pediatric Patients
- Lopinavir Area Under the Curve (AUC) [ Time Frame: pre-dose, 1,2,4,6,8, and 12 hours post-dose ]Lopinavir Area Under the Plasma Concentration versus Time Curve (AUC)
|Study Start Date:
|June 2006
|Study Completion Date:
|May 2009
|Primary Completion Date:
|May 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Whole Then Crushed Tablets
These subjects will take whole lopinavir tablets at Study Visit 1, and crushed tablets at Study Visit 2.
Drug: lopinavir/ritonavir (Kaletra®) tablets
The subject will bring their own prescription of lopinavir/ritonavir. The patient will take a witnessed dose of lopinavir/ritonavir with an 6 ounce glass of cool water (if taken whole) or mixed in 4 ounces of Jell-O brand pudding (if crushed).
Other Name: Kaletra®
Experimental: Crushed Then Whole Tablets
These subjects will take crushed tablets at Study Visit 1, and whole tablets at Study Visit 2.
Drug: lopinavir/ritonavir (Kaletra®) tablets
The subject will bring their own prescription of lopinavir/ritonavir. The patient will take a witnessed dose of lopinavir/ritonavir with an 6 ounce glass of cool water (if taken whole) or mixed in 4 ounces of Jell-O brand pudding (if crushed).
Other Name: Kaletra®
Detailed Description:
By the end of 2005, approximately 2.3 million children worldwide were living with HIV/AIDS.1 At least 660,000 children worldwide have advanced HIV/AIDS and are in dire need of antiretroviral treatment. While many barriers exist to scaling up HIV/AIDS care and treatment globally, access to life-saving treatments for children is increasing. The protease inhibitor, lopinavir/ritonavir (Kaletra®), is recommended as a first-line agent by the World Health Organization and by the US Department of Health and Human Services for the treatment of pediatric patients in resource-limited settings and in the United States.
The prescribing information states that these tablets may not be crushed, broken or chewed, and the manufacturer does not plan to examine the pharmacokinetics of crushed tablets at this time. The company found that the crushed tablets were poorly absorbed in a small pharmacokinetic study in several dogs. While this information has spread through investigators by word-of-mouth, this information has not been published in any forum by the company, and no guidance as to the extent of the decrease in absorption has been provided. However, patients and caregivers are dosing pediatric patients with crushed tablets to overcome some of the limitations of the oral solution. If crushed tablet administration yields significantly lower systemic exposure to lopinavir than whole tablets, then patients using this administration technique will be at higher risk for development of viral resistance and treatment failure. This administration technique must be studied so that providers have evidence to support recommendations about this dose administration strategy.
|Ages Eligible for Study:
|6 Years to 17 Years (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Documented HIV infection
- Taking lopinavir/ritonavir (Kaletra) tablets at standard pediatric doses for greater than two weeks
- Concomitant medications and/or natural products, including potentially interacting products, have been stable for greater than two weeks and are not expected to change over the course of the study
- Ability to understand study procedures and assent to participate
- Parental or guardian consent
- Aged 6 - 17 years
Exclusion Criteria:
- Acute serious medical illness or infection (in the judgment of the investigator)requiring treatment and/or hospitalization within 14 days prior to study entry
- Pregnancy
- Concomitant medications/natural products that have been started within past two weeks and/or that will be changed over the course of the study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00810108
|United States, California
|University of California, San Diego - Skaggs School of Pharmacy and School of Medicine
|San Diego, California, United States, 92103
|United States, District of Columbia
|Children's National Medical Center
|Washington, District of Columbia, United States, 20010
|Principal Investigator:
|Brookie Best, PharmD, MAS
|University of California, San Diego
|Responsible Party:
|Brookie Best, PharmD, MAS, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|ClinicalTrials.gov Identifier:
|NCT00810108 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 15, 2008
|Results First Received:
|April 25, 2012
|Last Updated:
|June 2, 2012
Keywords provided by Brookie Best, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):
resource-limited settings
antiretroviral treatment
crushed tablets
treatment experienced
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 21, 2017


text:
Friends and family so often asked Dr. Charles E. Davis, a specialist in microbiology and infectious disease, how to avoid getting sick when they travel abroad, he decided to put all his advice in one place. The result, "The International Traveler's Guide to Avoiding Infections," was released by Johns Hopkins University Press. Here's an edited chat with Davis:
What steps should you take before you depart?
If you're going to a developing country, visit a travel clinic four to eight weeks before you travel to get any immunizations you may need. You can find one on the websites of the International Society of Travel Medicine or the American Society of Tropical Medicine and Hygiene. Make an appointment with your primary care physician for an exam and for any routine immunizations like a DPT update, hepatitis A and B, and influenza; if you get these done at travel clinics, you run the risk of paying out of pocket.
Is travelers insurance worth getting?
Depends on your destination, your age, your health, what you're doing and whether or not you're a gambler. Some good (insurers) I recommend are FrontierMEDEX; International SOS; and CSA Travel Protection. You can comparison-shop at TravelGuard.com or InsureMyTrip.com.
What should you pack?
For any overseas trip, I recommend taking along self-treatment for traveler's diarrhea — loperamide, known by the brand name Imodium here, and an antibiotic, the most common being ciprofloxacin. Other things to pack: Band-Aids and topical antibiotics to treat minor wounds; water purification tablets; sunscreen; and insect repellent with 30 to 50 percent DEET. Hikers should bring a full suture kit.
While you're visiting a country, what should you keep in mind?
Avoid tap water and ice in developing countries as well as salads and buffets, which bacteria just love. A good rule to follow: Boil it, peel it or forget it.
And once you return?
If you were away longer than three months in a developing country, had done aid work or were exposed to needles or fresh water, or had been ill or had sex, I'd recommend doing a screen for various infections at a travel clinic.
— Emily Brennan, New York Times


text:
The Department of Business Administration and Economics at Georgetown College seeks to achieve the following goals:
- To provide students with the intellectual skills needed to deal with the problems, challenges, and opportunities that they will encounter throughout their lives. More specifically, we aim to
- develop students' abilities to analyze problems and formulate appropriate solutions
- develop students' abilities to communicate ideas effectively
- To prepare students to be successful and productive individuals. To do so, we strive to
- prepare students to begin meaningful careers immediately after graduation
- prepare capable, motivated students to enter good graduate or professional programs
- To promote growth of personal characteristics that will enable our graduates to become contributing members of their communities. Our specific objectives are to
- foster development of personal responsibility
- foster development of leadership skills
- promote global awareness
The Department is committed to providing a broadly oriented professional education to prepare students for careers in business, government, and not-for-profit organizations. Our majors in Business Administration are built around a large number of required core courses that provide our students the basic skills in the quantitative and qualitative aspects of Business Administration. The business program provides the students with the basic introduction to the primary functional areas of business, and the opportunity to pursue a limited specialization in one or more specific functional areas. Additionally, these courses allow the students the opportunity to develop a substantive business knowledge prior to choosing an area of specialization. A student majoring in a departmental program will be required to maintain a minor in an area of interest outside the department. If a student wishes to have more than one specialization, there must be three courses or nine semester hours in each specialization which are not counted in any other specialization.
Major in Accounting
(B.S. degree) Fifty-one hours in the Department of Business Administration and Economics including BUA 210, 211, 300, 310, 311, 318, 326, 330, 335, 336, 353, 357, 413, 415, 450; ECO 221, and 223; plus twelve additional allied hours consisting of MAT 109 and 111; COMM 115; and PHI 325. Total hours required, sixty-three.
Fifth-Year Program in Accounting (for students seeking to become Certified Public Accountants) Option 1: B.S. in Accounting from Georgetown College and a MS in Accounting or MBA from a public university (agreement in place with University of Kentucky). Option 2: B.S. in Accounting plus additional 28 hours from Georgetown College in the following two areas: A minimum of 6 hours from the following: BUA 470 Business Writing, BUA 340, BUA 377, ECO 425, COMM 200, COMM 310, COMM 312, COMM 400, POS 100, POS 315. A minimum of 6 hours from the following: BUA 470 Advanced Accounting, BUA 460 Internship, BUA 440 CPA Review, BUA 470 Tax Entities, BUA 470 Advanced Cost Accounting, BUA 470 Accounting Theory.
Major in Business Administration
(B.S. degree) Thirty-nine hours in the Department of Business Administration and Economics including BUA 210, BUA 211, BUA 326, BUA 335, BUA 353, BUA 357, BUA 450; ECO 221, ECO 223, ECO 324; for the emphasis, nine additional hours chosen as follows: for finance, BUA 342, BUA 363, and any additional BUA or ECO course numbered 300 or above; for management, BUA 367, BUA 377, and one of the following: COMM 312, PSY 365, or any additional BUA course numbered 300 or above; for marketing, BUA 346, BUA 355, and one of the following: COMM 315, COMM 415, or any additional BUA course numbered 300 or above; plus 9 allied hours consisting of MAT 109 or 121, MAT 111 and PHI 325. Total hours required, forty-eight.
Major in Economics
(B.A. degree) Thirty hours in the Department of Business Administration and Economics including BUA 210, BUA 211, ECO 221, ECO 223, ECO 311, ECO 313, and ECO 450; nine additional hours chosen from BUA 335, ECO 304, ECO 317, ECO 337, ECO 355, ECO 405, ECO 410, ECO 425, or ECO 470; plus 6 allied hours consisting of MAT 111 and either MAT 121 or MAT 109. Total hours required, thirty-six.
Minor in Business Administration
Twenty-one hours in the Department of Business Administration and Economics including BUA 210, 211, 326, 353, and 357; ECO 221 and 223.
Minor in Economics
Twenty-one hours; fifteen hours in the Department of Business Administration and Economics including ECO 221 and ECO 223; ECO 311 or ECO 313 or ECO 324; and six additional hours chosen from ECO 304, ECO 317, ECO 337, ECO 355, ECO 405, ECO 410, ECO 425, or ECO 470; plus 6 allied hours consisting of MAT 111 and either MAT 121 or MAT 109.
Additionally, the Business Administration and Economics Department participates in interdisciplinary majors in the following areas (B.S. degrees): Management Information Systems; and Business Administration and Ethics. Also, it offers an interdisciplinary B.A. degree in Commerce, Language, and Culture.
Business Administration Courses — (BUA)
210. Principles of Accounting I. (3 hours) This is a sequence course. It deals with the accounting policies, procedures, theories, and practices of merchandising and service concerns. Emphasis will be placed on the accounting cycle, balance sheet, income statement partnerships and the Generally Accepted Accounting Principles (GAAP). Achieving proficiency in Excel Spreadsheet is a course requirement. Fall and Spring
2 11. Principles of Accounting II. (3 hours) This is a continuation of BUA 210. Emphasis will be placed on the analysis of long-term liabilities and shareholder's equity, corporations, analysis of financial statements, taxes, and managerial and cost accounting for decision making. Prerequisite: BUA 210 and proficiency in Excel spreadsheet. Fall and Spring
300. Accounting/Management Information Systems. (3 hours) A study of the design of accounting information systems, including flowcharting, understanding specific accounting subsystems, using computerized accounting packages, and studying advanced spreadsheet applications. Prerequisites: BUA 211 and proficiency in Excel spreadsheet. Fall
310. Intermediate Accounting I. (3 hours) Review of the basic financial accounting process, the income statement, and the balance sheet. Topics covered in depth include accounting applications of time value of money and accounting for current assets, property, plant and equipment, and intangible assets. Prerequisite: BUA 211. Fall
311. Intermediate Accounting II. (3 hours) Continuation of BUA 310, including a study of current liabilities, accounting for long-term debt, stockholder equity, retained earnings, investments, revenue recognition, earnings per share, error analysis, statement of cash flows, and current value/constant dollar accounting. Prerequisite: BUA 310. Spring
318. Cost Accounting. (3 hours) Business cost accounting, special records and cost statistics and application to particular business organizations. Prerequisites: BUA 211, MAT 121 or 109, MAT 111. Fall
326. Contemporary Marketing. (3 hours) Current techniques of marketing including electronic commerce; addresses fundamental problems in producing, pricing, distributing and purchasing a product. Prerequisites: BUA 211, ECO 221, ECO 223, ENG 112, and either COMM 115 or demonstrated Power Point proficiency. Fall and Spring
330. Business Law. (3 hours) Principles of contracts, negotiable instruments, sales, bailments, real property, and personal property. Prerequisite: Junior standing. Fall and Spring
335. Principles of Finance. (3 hours) A study of the financial evaluation of interest, the time value of money, valuation of stocks & bonds, risk & return analysis, balance sheet analysis and capital budgeting techniques. Prerequisites: BUA 211, MAT 109 or 121, MAT 111, and ECO 221. Fall and Spring
336. Quantitative Business Methods. (3 hours) Quantitative analysis in support of managerial decision making, the modeling process, linear programming, simulation, decision theory, regression models, Q-Theory, and PERT. Prerequisites: MAT 109 or 121, MAT 111, BUA 211, ECO 223. Even Falls
340. Corporate Finance. (3 hours) Study of corporations, corporate combinations, and how they are financed. Particular emphasis given to major functions of departments, issuance of securities, managing corporate income, and taxation of corporations. Prerequisite: BUA 335. Odd Springs
342. Investments. (3 hours) Investigation of various investments. Primary emphasis on financial assets such as stocks, bonds, real estate, and insurance. Study of financial markets. Prerequisite: BUA 335. Fall
346. Marketing Research. (3 hours) A study of the applications of research in marketing decisions. Provides students with knowledge of marketing data and its use in decision making. Prerequisites: BUA 326, MAT 111, MAT 109 or 121. Spring
353. International Business Operations. (3 hours) A comprehensive course covering the internal and external environmental forces and their influence in all of the functional areas of the international firm. Topics include finance, management, marketing, production, and the multinational's ethical responsibility to the host country. Also considered are cultural, political, and legal constraints which affect international business operations. Prerequisites: ECO 221, ECO 223, BUA 211. Fall and Spring
355. Retail and Industrial Marketing. (3 hours) A survey of the retail function as it applies to marketing theory. Examination of methods of interpreting consumer demand, overview of the buying, store management, and operation functions. Familiarizes students with product development. Emphasis on differentiating industrial buyer decision processes, exploring industrial buyer behavior and managing the overall marketing program for the industrial products firm. Prerequisite: BUA 326. Even Falls
357. Current Issues in Management. (3 hours) Planning, organizing, leading, and controlling as discussed in current popular management literature. Prerequisites: BUA 211, ECO 221, ECO 223, ENG 112, and either COMM 115 or demonstrated Power Point proficiency. Fall and Spring
363. International Finance. (3 hours) Financing corporate enterprise in a world business environment. Examines the theory of international financial adjustments, the functions of financial institutions and the financing of trade. Evaluating foreign exchange markets, management of currency exposure, estimating country debt- servicing capacity and external debt financing problems. Prerequisites: BUS 335, BUA 353. Even Springs
367. Human Resource Management. (3 hours) Process and practices in human resource management including law, manpower planning, employee selection, development, motivation, performance, appraisal, compensation and union relations. Instructional method provides for case method, laboratory exercises and small group discussion. Prerequisite: BUA 357. Even Springs
377. Organizational Behavior. (3 hours) The study of individual and group behavior in organizations. Identification and application of behavioral science research theories and methods. Motivation, interpersonal and intergroup relations, communications, group dynamics, norms, leadership, power, conflict, values, task characteristics, formal managerial controls, and the process of organizational decision making. Prerequisite: BUA 357. Fall
413. Principles of Auditing. (3 hours) A study of the generally accepted auditing standards and their application by auditors. Prerequisite: BUA 300 and 311. Spring
415. Income Tax Accounting. (3 hours) Federal Income tax laws relating to both personal and corporate income; preparation and filing of returns. Prerequisite: Senior standing and consent of instructor. Fall
423. International Marketing. (3 hours) Environmental factors affecting world marketing management. Methods applied to estimate market potential and to select pricing and distribution strategies, communications to serve foreign markets, methods to serve the markets, management of marketing functions, and financing analyzed via case studies. Prerequisites: BUA 353, either BUA 326 or CLC 319. Odd Falls
440. Independent Study. (1-3 hours) Fall and Spring
443. International Management. (3 hours) The principles and special problems of management in an international context, dealing with both the parent company and the foreign affiliates. Emphasis on differences between domestic vs. international business situations in administration, marketing, finance, production, and personnel. Prerequisites: BUA 353, BUA 357. Odd Springs
450. Business Policy and Strategic Planning. (3 hours) Examination of the business enterprise as a total system in a total environment. Analysis and evaluation of the problems, opportunities, and ethical responsibilities which face a chief executive. Emphasis on formulation and implementation of various strategies. Extensive use of case problem analysis. Prerequisites: BUA 326, BUA 335, BUA 353, and BUA 357; this course should be taken as the capstone (last course) in the student's program of study. Fall and Spring
460. Internship. (1-3 hours) Fall and Spring
470. Special Topics in Business. (3 hours) Fall and Spring
Economics Courses — (ECO)
221. Principles of Macroeconomics. (3 hours) A study of national income determination, commercial and central banking, money, monetary policy, fiscal policy, economic growth, and the economics of trade and exchange rates. Some knowledge of basic mathematics and algebra as well as the ability to understand and interpret economic data is desirable. This course is not a prerequisite for Principles of Microeconomics 223. Fall and Spring
223. Principles of Microeconomics. (3 hours) The study of markets, supply and demand, value distribution, business organization, market structure, and selected problems in microeconomics. Some basic mathematics and facility with graphs are necessary. Principles of Microeconomics 223 may be taken before Principles of Macroeconomics 221. Fall and Spring
304. Regression Analysis in Business and Economics. (3 hours) Application of elementary econometric procedures and statistical inference as used in business and economics. Prerequisites: ECO 221, ECO 223, MAT 111. Odd Falls
311. Intermediate Macroeconomic Theory. (3 hours) Examination of determinants of aggregate income, the price level, and employment; the role of policy in influencing aggregate economic activity. Prerequisites: ECO 221 and 223; MAT 109 or 121 Spring
313. Intermediate Microeconomic Theory. (3 hours) Price theory, including analysis of consumer behavior, production costs, and firm behavior. Prerequisites: ECO 221 and 223; MAT 109 or 121 Fall
317. Economic History of the United States. (3 hours) American economic development from colonial times to Great Depression; economic analysis of impact of colonial system, free banking, and slavery; identification of major sources of economic growth. Prerequisites: ECO 221 and 223 or consent of instructor. Odd Springs
324. Economics and Managerial Decision Making. (3 hours) The application and extension of microeconomics to the problems and decisions of business firms relating to output and pricing policy. Prerequisites: ECO 223, MAT 109 or 121, MAT 111. Fall
337. Environmental Economics. (3 hours) Economic principles applied to environmental quality and resource utilization; origins of and approaches to environmental problems. Prerequisites: ECO 221 and 223 or consent of instructor. Even Falls
355. Public Finance. (3 hours) Institutional and theoretical perspectives of the role of government as an economic agent; impact of tax policy and spending programs within a market economy. Prerequisites: ECO 221 and 223 or consent of instructor. Even Springs
405. Government Regulation of Business. (3 hours) Application of the economic theory of industries and markets to government regulation; topics include legal foundations and economic impact of market regulation, antitrust policy, competitive practices, monopolies, and workplace safety. Prerequisites: ECO 221 and 223. Odd Falls
410. International Economics. (3 hours) Causes and consequences of international flow of goods, services, and money; topics include trade incentives, trade regulation, and foreign exchange markets. Prerequisites: ECO 221 and 223. Odd Springs
425. Financial Institutions and Monetary Economics. (3 hours) A study of banks and other institutions and their relationship to money and credit and their impact on financing business firms. Prerequisites: ECO 221 & 223, BUA 211. Even Springs
440. Independent Study. (1-3 hours) Fall and Spring
450. Senior Seminar in Economics. (3 hours) Examination and analysis of a current policy issue; capstone experience. Prerequisites: ECO 311 and 313; MAT 111. Spring
470. Topics in Economics. (3 hours)


text:
Normal Member
Tonight could see a massive reshuffle in the Heavyweight division. Cain Velasquez defends his title for the first time in his second reign against the monstrous Antonio "Bigfoot" Silva in a rematch from UFC 146. Velasquez got the upper hand then, using his superior wrestling and ground and pound to quickly stop his opponent. Many believe tonight will be no different but Silva is coming off
The glitz and glamour of Wrestlmania is now but a faint memory. From here and going forward the WWE will begin to build it's summer programs which should see most culminate at this year's Summerslam. Before they can do that however, that they have a few loose ends to tie up and since 2010, Extreme Rules has been the perfect event in which to do this. Will The Shield complete their rise to power when
After beating Jon Jones soundly with his better picks, tactics and overall coaching ability on TUF, "The American Gangster" Chael Sonnen hopes to take the one thing that truly matters; Jones' UFC Light Heavyweight title. It won't be easy though as in just two years "Bones" has decimated the 205 pound division, leading many to believe the young champion should consider a move up
Wrestlemania is to wrestling fans what Christmas is to children. Since 1985 it has been the number one wrestling event of the year and has become, to most fans, almost as big as the Superbowl. The last couple of years have seen WWE struggle to craft decent storylines heading into the event and this year has been no different. Regardless however, this year's instalment features a number of highly anticipated
Georges St-Pierre vs. Nick Diaz isn't just a fight. It's the culmination of a near three year long war of words between the two. The UFC has been set on these two fighting each other since early 2011 but through a comedy of errors and injuries, the long-awaited bout has been delayed...until now. Also on the card is the almost equally anticipated fight between two other Welterweight contenders, Carlos


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ANCHORAGE, Alaska (AP) — Rodeo cowboy Frank Koloski has been gored before, but never at an event he sponsored.
The founder and co-owner of Rodeo Alaska on Saturday was promoting and participating in the Alaska Sales & Service Bear Paw Rodeo Round-Up and took a steer horn to the abdomen.
"I have a nice little hole in me," he said Monday from his hospital bed.
Originally from St. Cloud, Florida, Koloski's specialty is "double mugging," an event in which one cowboy on a horse ropes a steer while another on foot tries to wrestle the animal to the ground, the Anchorage Daily News (http://bit.ly/1jI8MzV) reported.
Koloski on Saturday night was the cowboy on foot.
"It was just pretty wild," he said. "When I went to take him down, I felt him hit me."
He also saw blood on his shirt. The bull's horn had punctured him below his stomach and pushed in about 4 ˝ inches, he said. He tried to "kind of trot" out of the arena but got lightheaded and fell.
"Embarrassing," he said.
He took a ride to Providence Alaska Medical Center for surgery. His doctor spotted a scar on his leg where he had been gored before.
Koloski managed to win the double-mugging event despite the wound and was awarded $1,000 and a belt buckle.
He expects to be released from the hospital Monday or Tuesday, he said. He plans to heal in time to participate in upcoming rodeos: the Aug. 1-2 Tanana Valley State Fair in Fairbanks, which he believes is the farthest north rodeo in the country, and the "Tough Enough to Wear Pink" rodeo Sept 5-6 in Anchorage, which raises money for breast-cancer awareness.
He may pass on double mugging.
"I should be OK to do team roping," he said.


text:
It set records for both local and national viewership. I saw Hicks tweet it earlier, but now I can't find the stats.
Has anybody seen the numbers?
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It set records for both local and national viewership. I saw Hicks tweet it earlier, but now I can't find the stats.
Has anybody seen the numbers?
This space for rent.
Last night's game was highest-rated regular season Pacers telecast ever on @FSIndiana. 9.33 household rating in Indy: http://t.co/wPaiCjlR52— Indiana Pacers (@Pacers) December 11, 2013
#NBA reports Tuesday's #Pacers vs. #Heat game averaged 920,000 viewers on NBA TV, making it the most-watched game in the network's history.— IndyStar Sports (@IndyStarSports) December 11, 2013
national viewership was 920,000, highest ever on NBA TV
Candace BucknerLast night's NBA TV telecast of the #Pacers win over the #Heat was the network's most-viewed telecast ever.
https://twitter.com/CandaceDBuckner/...80738293071872Candace BucknerThe game generated an average of 920,000 total viewers, blowing away previous most-watched matchup (LAL vs POR, 10-31-12, 868,000 viewers)
More than the Los Angeles Anybodies vs the New York Whosoevers? Impossible!
[~]) ... Cheers! Go Pacers!
\dr. evil
Wait, wait wait. 920,000 is just the number who watched on NBA TV, right? So people who watched on FSN should be added to that total? How does a 9.3 translate out into actual numbers of people?
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that's 9.3 of Indianapolis households too, it does not seem to count those of us not in indy but watching FSN
an an ABC TV marketing executive mutters....
"So, why is it, again, that we are showing 6 Knicks games this year, and zero Pacers games? When was the meeting where we decided on that?"
The poster "pacertom" since this forum began (and before!). I changed my name here to "Slick Pinkham" in honor of the imaginary player That Bobby "Slick" Leonard picked late in the 1971 ABA draft (true story!).
Their train of thought never contemplated the game of basketball. It was limited to a contest between the following:
over this:
I think we will be on NBATV more and possibly on ESPN more.
Just because you're offended, doesn't mean you're right. ― Ricky Gervais.
This space for rent.
This space for rent.
Last edited by imawhat; 12-12-2013 at 11:25 AM.
Not too suprising, this is probably the best rivalry (yes, I used the R word) in the NBA currently, and an absolute treat to watch.
The two teams do not like eachother at all, and no matter how many times we hear a player on either side say "it's just one game out of 82" we know that is just some PR bs. Both of these teams are good enough to basically just coast through most other teams in the league, but when they face eachother an intensity from both sides comes out that you do not see elsewise.
The ECF this year is probably going to be a better series than the finals, it's gonna be a hell of a fun series to watch, and I'd expect that this viewing trend continues during it. Probably multiple viewing records will be shattered this ECF.
People love to see a team beat the Heat. and Pacers can beat the Heat.
Should be interesting to see what the ESPN numbers are next week.
Hopefully this means Pacers Heat, Prime Time Christmas Day next year!
Garbage players get 1st round picks, (WTF)! All of the NBA must hate the Pacers! LOL
I think the only night where NBATV has flexibility is Tuesday fan night. Looking at our Tuesday schedule. We play the Lakers on 1/28. lakers again 2/25. Warriors 3/4. Without looking to see what other games are played on those days, all three of these games might be voted in. We also play the Hawks twice, Raptors and Boston on Tuesday night, but I doubt those will be voted in.
ESPN changes their schedule from time to time. TNT rarely if every changes their Thursday night schedule because there are usually only 2 games on Thursday nights. ABC will change their Sunday afternoon schedule if they can - only game I could see they might change to is Thunder vs pacers on 4/13.
Pacers have to be one of the top 2 or 3 positive NBA stories nationally to this point in the season.
Last edited by Unclebuck; 12-12-2013 at 12:14 PM.
I'm starting to think the Pacers will end up being the local favorite team over the Colts the next few years
9.33 is great locally for the pacers. of course the Colts typically get 35.0 - 40.0 for a normal Sunday afternoon regular season game. I think the Manning game this year was around 50.0.
Wish the pacers game could be on local ABC, NBC or CBS station, then we could compare apples to apples. My wild guess is if the heat game would have been on NBC locally it would have gotten around a 15.0 or so. maybe up to a 20.0.
Still 151K in Central Indiana seems pretty low for such a highly anticipated game. You have to wonder if people in Indiana, just generally do not like the NBA.
You can't get champagne from a garden hose.
I wonder how many people who are very casual fans even know where to find FSI on thsir cable or satelitte lineup
Hard to compare a Weekend game broadcast over the air with a weeknight game on not-so basic cable. I would guess that 15-20 percent of the population is at work at 7 on Tuesday nights.
Next Wednesday's game against the HEAT will be on ESPN. The numbers will be much larger both nationally and locally because there are a greater number of people that have ESPN and are more familiar with it than those who have NBATV and FSI combined.
Say what you will about ESPN but they aren't called the "Worldwide Leader of Sports" for nothing!


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Jericho, UT – Factory FMF/KTM rider Kurt Caselli took his fourth consecutive win of the AMA National Hare & Hound Series at the sixth round held in Jericho, UT.
Caselli got off to a great start sitting in third position at the end of the bomb run. His teammate, Ivan Ramirez, earned the holeshot and led the pack as they began the first loop.
Caselli quickly passed into second place part way into the first loop. Moments later he was able to get around his teammate after Ramirez got turned around on the course. Once in the lead, Caselli quickly gapped the field and went on to collect his fourth win of the season with a four minute lead over the second place ride of Jacob Argubright. Ramirez eventually got back on track and was able to come back to a fourth place finish.
"The weather was amazing at this race," remarked Caselli. "It was great for riding but a little dusty until I got out front. Once I was in the lead, I was able to just cruise and ride it in for the win."
Next Event: Jericho, UT – May 18, 2013
Overall Results
- Kurt Caselli
- Jacob Argubright
- Nick Burson
- Ivan Ramirez
- Robert Underwood
Overall Point Standings –
Kurt Caselli – 145
Jacob Argubright – 122
Nick Burson – 114


text:
Cozy,Central miniapartment #4 WIFI
Size19 m²
Floor No.(with elevator)
- Family/child friendly
- Internet/WiFi
- Kitchen
- Smoking allowed
- Lockable room
- Towels
- Elevator in building
Accommodation summary
|Orebitská, 130 00 Prague, Czech Republic
|Property type
|Private room
|Property ID
|Acceptance rate
|Response time
|A few hours
|Calendar updated
|5 days ago
This mini apartment Is equipped with most recent technical systems of access with plastic magnetic cards, wifi access to Internet, satellite television with more than 500 free channels.This small apartment of around 18 square meters is divided into one room and a private bathroom with bath / shower with separate entrance and a common corridor. High-speed internet access is for free.
Facilities are:
- safe,
- fan,
- heating,
- independent entrance,
- parquet or wooden floor,
- wardrobe / closet,
- hairdryer,
- towels, linen
- shampoo, bath foam, soap
- toilet,
- bathroom,
- shower,
- fast internet access WIFI,
- satellite channels,
- cable channels,
- LED screen TV,
- refrigerator,
- espresso machine Nespresso,
- microwave owen,
- toaster,
- electric kettle.
Situated practically on the border of the historical centre of Prague, 10 minutes walk from the Republic Square where the Powder Tower and the Municipal House are situated. It will take you less than 15 minutes to get to the Old Town Square or to the Wenceslas Square . 10 mt.
from apartment is a fornished non stop minimarket, many restaurants, coffeetterias, and shops.
One tram stop from Central Railway station and one bus stop from the bus terminal in Florenc. Easy connection from/to Prague airport.
The best choice for families or a group of friends!
House rulesDear Friends,
Will be a pleasure to meet you in Prague.
Only one thing before we accept your booking request:
we would like to ask you respect usual rules as to not be noisy from 10 p.m. till 6 a.m, don´t smoke in apartment, but only in the inner court.
Please, respect properties in our apartment and in the building. Official check out is at 11:00, if there are no guests coming same day, it's possible to stay till the evening.
Deposit : 75 Euro
Children FREE:
• until the age of ten with extra bed.
Thank you very much :-)
|Price for > 1 guests
|10 NZ$ per guest/night extra
|Check-in after
|Check-in before
|On arrangement
|Check-out before
|Cancellation Policy
Reviews of this property
It was much more comfortable to have an apartment in the city center and to reach everything by walking, so this was a perfect location!
We reached the apartment within 10 minutes from our bus station where we arrived.
Max, already a colleague of us, welcomed us warmly and me and my friend felt pretty comfortable there! (even had welcome-sweets!)
The one-room apartment was fitted with daily necessaries e.g water heater, microwave (which we used for delicious cheese tomato sandwiches), coffee machine and hairdryer.
After a day of 10h walking, it felt a bit like coming home :)
I recommend this location for a enjoyable visit in Praha. You need a place to stay where you can feel comfortable and this was definitly one.
Thanks for having us, Max and Hely! :)
Квартира имеет все необходимое для проживания. Можно пешком дойти до вокзала и центра города или рядом есть остановки общественного транспорта. Макс дал мне всю нужную информацию. Спасибо Хели и Максу за гостеприимство!
The appartment was exactly the way shown and advertised on wimdu. We had a hearty welcome, arrival, stay and departure went smooth. We also got a phone number in case of advice or help which we didn't need to use. The accommodation was central to the city, public transport was close and nice places for breakfast and dinner as well. I'd definitely go there again!!!
Ich war sehr zufrieden mit meinem Zimmer, auch wenn alles sehr alt ist!
Für einen Single ist es nur zu empfehlen!
Es ist alles sauber und in Ordnung!
Auch ist der Gastgeber Max ein sehr höfliche, nette, hilfsbereite und zuvorkommende Person!
Nochmals, ich kann es für einen Single nur weiterempfehlen!
Alles vorhanden, Mikrowelle, Toaster, Wasserkocher und Kaffeemaschine.
Für den Anfang war auch alles vorhanden, Schinken, Käse, Marmelade, Butter, Toastbrot, Kaffee und Wasser.
Wenn ich wieder nach Prag komme, werde ich wieder dieses Zimmer nehmen.
Een prima appartement met alles er op en eraan. Aanrechtje, magnetron, koelkast, broodrooster, waterkoker en koffiezetapparaat.
We werden hartelijk welkom geheten. Er lag zelfs brood klaar voor ons eerste ontbijt, boter in de koelkast en cupjes met jam. Voortreffelijk. In de douche was ook alles keurig verzorgd; shampoo en haardroger, zeepjes. De douche had wel een wat hoge opstap.
De locatie was net buiten het centrum, maar uitstekende verbindingen met bus of tram, naar hartje stad.
Al met al waren wij zeer tevreden.
The owner has been very friendly and helpful. The apartment was as expected in the description and the stay there was very enjoyable.
I recommend it!
Alles perfekt für mich: sehr netter, hilfsbereiter Gastgeber hat mich in Empfang genommen, alles topsauber, Küchenteil, Bad und Zimmer mit allem denkbar Nötigen ausgestattet, gute Verkehrsverbindungen (Busse um die Ecke), nicht weit vom Zentrum, 24 h - Minimarkt gleich nebenan, sehr ruhige Unterkunft (ich habe lange nicht mehr so gut geschlafen).
Brigitte Grove
Sehr kleines Appartment... liegt sehr günstig, nur 5 min bis zum Bahnhof und 15 min bis zum Center.. Alles sehr gut, einziege was mir gestört hat ist die ausziehbare Sofa... sonst bin sehr zufrieden..
werde auf jeden Fall wieder nehmen..
hey, alles in allem eine gute unterkunft für einen kurzen abstecher nach prag. das zimmer liegt verkehrsgünstig an der buslinie 207 mit der man in kürzester zeit ins zentrum gelangt. in direkter nähe gibt es mehrere minimärkte in denen man das nötigste Einkaufen kann. auch laden, nur ca. 5 minuten entfernt, einige lokale zur einkehr ein. wir hatten einen schönen aufenthalt bei hely und ihrem mann und wir würden wieder buchen. unsere note : 2 +
The hosts Hely by email was most kind and helpul giving plenty of indications as how to arrive from airport,and her husband Max was there to receive us with the key and was also very helpful and friendly giving us all kind of tips as to how to get around and services near the apartment.
The apartment was another story: it needs a THOROUGH clean up, the bathroom walls looked incredibly dirty and full of the water drops plus the soap from many, may showers and had never been cleaned, also the small fridge made all kind of loud noises and even for two exhausted people walking around 12 kms each day, was very difficult to get sleep. The bed is a sofa-bed squeaking loudly each time one of us moved and the curtains did not completly cover the window. Very basic and some water spilled on the floor, the paper was black which indicated that floor was VERY dirty, and so was the waste paper basket, absolutely dirty!! So my request to the frindly hosts Hely and Max is that since they are so kind and rent for a convenient fee their apartmen. it would be most appreciated from new arrivals if the apartment was CLEAN and paid a little extra attention to details (after all is in the best interest of their businness isn't it??) All together conveniently situated about 800 meters from the nearest bust or tube station Florenc and just a few meters from bus stops. If you are a sound sleeper and don't mind sleeping on a noisy couch and are not too fussy about cleaningness...then,,you may consider this stay. Max you said you expected a good critic, I would have loved to since you are a very nice person but I am a fair critic and you ought to better your offer, it's true is a fair price but a little water and soap isn't so expensive.
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Paula Patton
Having starred alongside such big names as Will Smith, Jessica Biel and Denzel Washington, Paula Patton has enjoyed steady success in Hollywood, culminating in her role costarring alongside Tom Cruise in Mission: Impossible - Ghost Protocol.
While promoting her film in India, Paula Patton sang the praises of her Indian costar Anil Kapoor and made statements that suggest she's hoping for an offer from a Bollywood director. Are times so hard in Hollywood that its biggest stars are considering relocating to India?
While promoting her film in India, Paula Patton sang the praises of her Indian costar Anil Kapoor and made statements that suggest she's hoping for an offer from a Bollywood director. Are times so hard in Hollywood that its biggest stars are considering relocating to India?
AppealPaula Patton's got it going on. Any woman who's got the gumption to land a leading role in a Mission Impossible film is guaranteed to make men groan with the barest of glances. Wherever Paula turns up next we'll be sure to be watching.
SuccessAfter graduating from USC film school Paula Patto quickly made the jump from working behind the camera as a producer for the Discovery Health Channel's show Medical Diaries to a role in front of the camera alongside Will Smith and Eva Mendes in Hitch. She's continued to build her career with a role alongside Outkast in Idlewild and most recently opposing Tom Cruise in Mission: Impossible - Ghost Protocol.
Paula Patton BiographyRaised in Los Angeles, Paula Patton has been pursuing her dreams of becoming an actress ever since she was a little girl. Having grown up in the entertainment capital of the world, Paula began preparing for a career in the business while still in high school. Paula's teen years were spent at the prestigious Hamilton School for the Performing Arts, where the would-be performer spent hours honing her craft. After graduating, Paula received the opportunity of a lifetime when PBS selected her as one of four young filmmakers to participate in a program called The Ride, in which she was given access to equipment and a small crew and told to film her experiences with other youths across America.
Following that experience, Paula enrolled at UC Berkeley, though she transferred to USC Film School after her first year, and went on to graduate magna cum laude. It wasn't long before Paula, with her experience on The Ride and her education behind her, managed to land a job with the Discovery Channel as producer for the show Medical Diaries.
Paula eventually grew tired of toiling behind the camera and decided to sign herself up for acting classes. She consequently began the arduous auditioning process, finally landing her first role opposite Will Smith and Eva Mendes in 2005's Hitch. She followed that up with a small part in the little-seen drama London (also released in '05 and featuring Chris Evans, Jessica Biel and Jason Statham), and appeared alongside OutKast boys Andre Benjamin and Big Boi in Idlewild (2006).
Paula was also cast in the 2006 film Déjà Vu, a thriller starring Denzel Washington and Val Kilmer.
In 2008, she appeared in the film Mirrors with Kiefer Sutherland. The following year, she appeared in the critically acclaimed film Precious as a teacher who mentors the film's main character.
In 2010, Paula Patton started appearing regularly as the new assistant DA on the long-running NBC drama, Law & Order: SVU. Although she was intended to be a recurring character on the show, soon after she was cast she won the role of the female lead in Mission: Impossible - Ghost Protocol opposite the franchise's male star, Tom Cruise. Her role on SVU was therefore shortened to just one episode.
Paula Patton made waves on location for MI in India, where she publicly stated that she'd love to work with Aishwarya Rai and praised her costar Anil Kapoor's acting skills.
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Arts and Minds
Growing up in Northern Virginia, Lily Sehn '14 dreamed of becoming a doctor and an artist. The ambition to become a physician like her father faded over time. But visiting art museums throughout Europe and the United States with her family set her on a course she has pursued with a singular focus.
Before coming to AU, second-year AU art history master's student Sehn had had a world of exposure to the art field. She studied art for a semester in Florence and spent a summer in Rome working for the Patrons of the Arts in the Vatican Museums, an office that funds restoration projects and which allowed her access to the museums' extensive collection.
As an undergraduate at Loyola University Maryland, Sehn studied the history of printmaking in a seminar at the Baltimore Museum of Art. She also spent a year at the Walters Art Museum in Baltimore facilitating educational programs.
"I've always enjoyed making things," says Sehn, who does printmaking, watercolor, and digital media, "but I've also always had an appreciation for the biographies of artists and understanding that they absorb history and their own feelings and emotions and are able to bring that out in a visual plane."
AU has not only sharpened Sehn's focus but also given her a boost toward achieving her goals. As an intern this summer at the Phillips Collection in Washington working with curator Elsa Smithgall, she helped facilitate an exhibition demonstrating how the 1913 Armory Show influenced the collection of Duncan Phillips. The International Exhibition of Modern Art, which opened in February 1913 at New York City's 69th Regiment Armory, was a hugely influential—and, for many, shocking—show.
"The year after the exhibit, Duncan Phillips wrote extensively on the Armory Show and sort of railed on Cezanne, Matisse, and Van Gogh and some other artists he thought were just awful," Sehn says. "About 10 years later, he changed his mind about a lot of them. And so he ended up incorporating a lot of works by these artists in his collection. We looked at the Armory Show and its impact— but mostly its impact on his collection and on him."
She also worked part-time for a year as a museum assistant at the Phillips Collection. Sehn, who has a fellowship in the Department of Art, is a Graduate Student Council representative. She also is a big part of the operation of her department's annual Feminist Art History Conference, which will be held this year from November 8 to 10.
"Lily contributed tremendously to the success of the Third Annual Feminist Art History Conference," says Kathe Hicks Albrecht, visual resources curator at the Katzen Arts Center's Visual Resources Center. "Lily handled registrations, created publicity, and served as an invaluable member of the team."
Sehn is capping her final year with the perfect experience. This fall, she began a graduate-level internship for the 2013–2014 academic year working in the curatorial department of the Smithsonian American Art Museum.
"Museums make art accessible to everybody," Sehn says, summing up her love of the institutions. "Whether you know a lot about art or nothing at all, you can appreciate something just by looking at it. Whether you like it or it brings out some emotive response, just looking at art will do something to you."


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While there is good news about the local fundraising effort for children with special needs, there is also a caveat.
They are the ones who work behind the scenes to make things happen.
Monday night, Aug. 5, Hulu aired episode one of "Quick Draw," and Great Bend, the setting for the web-exclusive series, jumped onto Hollywood's radar. It's part of a trend in bringing original content to audiences that once only came from the big three networks and later cable television. One caveat: the show is definitely geared toward a mature audience.
The Barton Community College Board of Trustees on Thursday approved next year's budget, which calls for no increase in the mill levy.
This story has been updated.
The committee appointed by Great Bend Mayor Mike Allison to sharpen vicious dogs regulations voted Wednesday night to add tethering restrictions to the list of recommendations it will forward to the City Council.
Each week we'll take a step back into the history of Great Bend through the eyes of reporters past. We'll reacquaint you with what went into creating the Great Bend of today, and do our best to update you on what "the rest of the story" turned out to be.
Although a nice relief from the drought, recent rains have caused flooding and lots of puddles of standing water, ideal breading conditions for mosquitoes.
As the area has been inundated with rain of late, the City of Great Bend has remained relatively unscathed, City Administrator Howard Partington told the City Council Monday night, due in large part to the levee system encircling the community.
The U.S. Army Corps of Engineers public comment period for two proposed oil wells inside the Cheyenne Bottoms Wildlife Refuge came to an end July 14. The vast majority of comments collected indicate public concern for the wildlife that inhabits and uses the wetlands area as a migration stop-over. Overwhelmingly, both private individuals and governmental organizations ask the applications by H&C Oil Operating, Inc. and L.D. Drilling, Inc. be denied.
Heart Of Kansas Family Health Care will host a free Health Fair Saturday in Great Bend. The event is set for 9 a.m. to 1 p.m. at the Great Bend Convention Center, 3111 10th Street.
When communities are flooded, homeowners' and businesses' first response is to ensure the safety of loved ones and staff and then prevent as much damage as possible and in the days following, everyone's focus turns to the clean-up effort and getting all utilities in working order.
For Ellinwood residents only, the Red Cross will be providing Emergency Clean Up Kits which include bucket, floor squeegees, mops, bleach, gloves, masks, and bug spray. They will be available Tuesday afternoon at the City Office.
The City of Great Bend wants to help citizens have lots of fun and create memories, said Community Coordinator Christina Hayes. That's why this years September feature is "Party in the Park."
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Butterflies were in abundance at the Kansas Wetlands Education Center nature trail Saturday, enough to hold the interest of hundreds of young butterfly hunters and ...
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Inspired by rustling rainbow coloured sweet wrappers, a metallic clutch is for life not just for Christmas…
June 30, 2017
June 30, 2017
June 12, 2017
May 25, 2017
May 16, 2017
May 10, 2017
March 28, 2014
Inspired by rustling rainbow coloured sweet wrappers, a metallic clutch is for life not just for Christmas…
March 21, 2014
In celebration of our sweet shop inspired SS14 collection we've teamed up with sweet connoisseurs Spun Candy!
March 17, 2014
Last Thursday saw some of the UK's biggest beauty bloggers take over the Ellis Street store for the launch of my collaboration with Birchbox.
March 06, 2014
I'm delighted to announce our partnership with beauty and lifestyle brand Birchbox for a Special Edition March box.
March 06, 2014
Photographer David Bailey is renowned for his outstanding contribution to the photography world, so I was delighted to see his Stardust Exhibition open last month.
March 02, 2014
We're in the midst of a glittering awards season and yet the best is yet to come with the king of all awards ceremonies looming over us; The Oscars.
February 24, 2014
I recently came across an amazing new gadget, the Autographer camera, and thought what better way to share my world during LFW!
February 14, 2014
Highlights from London Fashion Week…
February 13, 2014
Our lowdown of where to visit during LFW….
February 07, 2014
Loved and loathed in equal measures Valentine's Day is just round the corner and what better occasion to treat yourself or a loved one to a piece of delectable arm candy.


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Hey there, time traveller!
This article was published 12/8/2013 (1506 days ago), so information in it may no longer be current.
A piece of aviation history touched down in Winnipeg Monday. A B-17 bomber, one of only a handful that are still airworthy, will spend a week at the Western Canada Aviation Museum. Free Press photojournalist Boris Minkevich caught the bomber, dubbed Sentimenal Journey, both in the air and on the ground.


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Next In DBZ Series...
Following the release of the Figuarts Zero Super Saiyan Son Goku (see our story HERE) will be Figuarts Zero Super Saiyan Trunks. What this figure lacks in articulation, it makes up for in precise detail, such as translucent hair. Brilliant effect parts and a special display stand are also included in the set. A Tamashii Web Exclusive in Japan, this figure will see a release in the U.S. January 2014, thanks to the folks at Bluefin. $33.99.
To insure your action figure collection, get in touch with Collectibles Insurance, the official insurance company of the Figures.com network. Say "Figures.com" to get 5% off your first term premiums.
To buy action figures, take a look at BigBadToyStore.com, AlterEgoComics.com, Toynk.com, BriansToys.com, ToyWiz.com, and MonkeyDepot.com.


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Are men better savers than women? New data released Tuesday suggest that the answer to this question is … Yes.
The average man with a savings-related account has a balance of nearly twice that of the average woman, according to the March 2013 U.S. Consumer Savings and Debt Report by SaveUp, a national online financial rewards program.
Men have higher balances in their certificates of deposit, 401(k)s, individual retirement accounts and taxable investments. The only account type in which women have an edge is money market accounts.
"Women and men are in significantly different positions financially in planning for their future financial security," says Priya Haji, CEO of SaveUp.
Women are more conservative with their financial choices and have low exposure to high-yield investments, which can hinder savings efforts in the long term. However, they are investing more in higher education, which accounts for their higher average student loan debt compared to men -- $41,405 versus $39,104.
When asked to assess their own saving strength versus that of men, 73.2 percent of women believe they are better savers than men, but the data show that men take more risk to secure their financial future and have 30 percent more invested in taxable investments than women.
One of the reasons for the difference in savings efforts is the income disparity between men and women wage earners.
"It's not just (women's) choices and behaviors that matter, there's also some really important structural issues in our society -- mostly wage inequality -- that we're seeing translate into a lower status of total savings," Haji says.
Just as Sheryl Sandberg, Facebook's chief operating officer is -- in her new book, "Lean In" -- asking women to "lean in" when dealing with workplace issues, SaveUp's report asks them to do the same when it comes to future financial stability by following these guidelines.
- Negotiate for increased wages.
- Aim higher on the amount you save monthly.
- Increase exposure to market returns on long-term savings.
- Maintain low, unsecured debt.
- Continue investing in higher education and career growth.
Do these findings surprise you? Share your thoughts below.
Follow me on Twitter @CrissiPonder.


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Morse says broken finger isn't reason for slump
SEATTLE -- Michael Morse conceded that he's not fully recovered from a fractured right little finger, but he said the injury has little to do with the fact that he's slumped of late and is batting .231 with 24 strikeouts.
"It's not an excuse or anything," Morse said. "I'm not producing because of me, not my finger. I don't look for excuses."
On Thursday night, Mariners manager Eric Wedge gave Morse a night off, starting Jason Bay in left field and recent callup Carlos Peguero in right.
"We felt like from yesterday morning to tomorrow night is the greatest amount of time we can give him to try to help it improve," Wedge said. "He still feels it, but it's improving. It's going to take some time."
Morse pointed out that he usually begins seasons slowly. This year, he's already got six home runs and 10 RBIs.
"I already have career records in April for everything I've done," Morse said with a smile. "I look at it like I'm having a good April."
Doug Miller is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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News and media
|Remove year: 2012
Urban innovation: how to finance a sustainable infrastructure
The Swiss Energy Council, WEC's Swiss committee, was a supporting organisation for the 2nd Sustainable Infrastructure Financing Summit, held in Basel, Switzerland, on 21–22 February. This was the second time that the Swiss Energy Council has supported the summit, the last one held in 2010. The recent summit, with its substantial delegations from Asia, showed […]
Posted on 1 March 2012
WEC Africa regional event builds energy future for the continent
Africa Energy Indaba 2012, held during 21–23 February in Johannesburg, South Africa, is Africa's leading energy gathering which aims to facilitate interaction between energy leaders as they work towards a sustainable energy future for the continent. In her opening speech Dipuo Peters, South Africa's Energy Minister, recognised the importance of the forum and thanked the […]
Posted on 1 March 2012
World Energy Council survey reveals the issues likely to impact Africa's energy agenda
African energy leaders see energy prices, energy poverty, and instability in the Middle East and North Africa (MENA) region to be the most important critical uncertainties in Africa's energy sector, according to the newly released African survey of the World Energy Issues Monitor, published by the World Energy Council. The survey is the first ever […]
Posted on 21 February 2012
World Energy Council welcomes its 21st African member
The World Energy Council (WEC) welcomes Zimbabwe as the latest member committee in Africa to join the world's largest inclusive and impartial all-energy forum working towards a sustainable energy future. As the 21st African member country, Zimbabwe follows Chad and Bolivia, which joined the WEC at the end of 2011, and brings the WEC network […]
Posted on 20 February 2012
Interview: Süreyya Yücel Özden, Chair of WEC Turkey
Süreyya Yücel Özden, Chair of WEC Turkey, talks to WEC Inside about the Turkish energy sector ahead of WELS Istanbul in April What is Turkey's strategic role in the global energy sector? Turkey is located between Europe – one of the largest energy-consuming centres of the world – and the Caspian region – one of […]
Posted on 15 February 2012
Christoph Frei meets with Ban Ki-moon, UN Secretary General
Dr Christoph Frei, the World Energy Council's Secretary General, met with Ban Ki-moon, UN Secretary General, on Friday, 10 February at the United Nations headquarters in New York. At the meeting Christoph Frei presented a letter on behalf of WEC Members and Officers formally supporting the UN's "International Year of Sustainable Energy for All". He […]
Posted on 12 February 2012
The World Energy Council welcomes Estonian Deputy Secretary General for Energy, Einari Kisel, as a Senior Fellow
Former Estonian Deputy Secretary General for Energy, Einari Kisel, joins the World Energy Council (WEC) as a Senior Fellow, European Policies and Partnership Development. Kisel will be responsible for developing WEC's Patron and Global Partner programme, helping new partners to engage with our network of 3000 member organisations. Kisel will also help strengthen and build […]
Posted on 1 February 2012
The World Energy Council signs strategic alliance with the Paul Scherrer Institute
Following their successful collaboration on the "Global Transport Scenarios 2050" study, the Paul Scherrer Institute (PSI) and the World Energy Council (WEC) have signed a three year strategic partnership agreement. The contract signed between Dr. Christoph Frei, Secretary General of WEC and Prof. Alexander Wokaun, Vice-Director of PSI, will see Switzerland's world renowned research centre […]
Posted on 27 January 2012


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Here's my belly profile today - at 30 weeks...
I'm still feeling well, just a bit uncomfortable at times. I'm sure that's due to the baby crowding out internal organs including my lungs. Other than that, couldn't be better!
We started taking Bradley Method Classes last week which will run for 9 weeks. We watched some videos (circa 1980's & 1990's) showing home births, water births, and the like. Graphic to boot but obviously we'll be in the same situation so its probably a good thing to see it now, um, especially for husband. I'm going to my first La Leche League meeting tonight to leach whatever info I can on nursing, and I've been reading The Womanly Art of Breastfeeding (7th Edition) and I'm starting to feel more confident and well-informed about breastfeeding. I highly recommend this book as it covers every single concern/question/problem/technique you could possibly think of. I feel like there is still a lot to prepare for... with only about 10 more weeks to go!
The crib quilt is coming along slowly but surely - I've got the 1st side half way pieced and hope to finish it this week. I'm also going to start figuring out curtains, and some cute bunting to string above the crib. And I HAVE to mention the fun clock I found that's perfect for the nursery.... and I'm lucky to have a C&B just a few miles away. I figure it could also find a home in the kitchen if necessary. Yes, I'm a sucker for green... ~sue me~


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McALLEN, Texas — The new tomato suspension agreement's arrival came just in time to make it the hot topic at the third annual America Trades Produce conference.
This year's ATP conference drew around 350 attendees, said Mission-based Texas International Produce Association president Bret Erickson, and a March 7 session detailing floor prices, package and labeling requirements and documentation mandated under the new agreement (established March 4) drew attendees and produced heated discussion.
The conference is a joint venture between TIPA and Nogales, Ariz.-based Fresh Produce Association of the Americas.
Details came out about potential pitfalls for shippers and importers under the revamped suspension agreement, and session co-moderator Lance Jungmeyer, FPAA president, stressed the importance of record keeping for all handlers.
Along with two seasonal per-pound reference price tables (from 31-59 cents Oct. 23 to June 30 and from around 2.5-4.7 cents July 1 to Oct. 22 depending on method used to grow and pack), comes expanded requirements for box labeling, Jungmeyer said.
While the wording of the agreement mentions "controlled environment," Jungmeyer said box wording should be "greenhouse," for example, for any tomatoes grown indoors, as described in the Florida Tomato Marketing Order.
Grape, cherry and heirloom varieties must be now be labelled "specialty," Jungmeyer said.
These new requirements complicate matters for repackers, who might import bulk tomatoes before putting them in clamshells, said Martin Ley, vice president of Nogales importer Del Campo Supreme.
Ley, who moderated the session with Jungmeyer, also stressed the importance of documentation.
The fact that the tomato suspension agreement had been in place for 16 years with no violations cited by U.S. regulators is cause for concern, Ley said.
With four specific divisions of tomatoes, where the previous agreement had one, chances are good a company will catch the attention of Department of Commerce regulators, and whoever buys or receives tomatoes will be responsible under Persihable Agricultural Commoties Act, Ley said.
"Someone will be a guinea pig," he said.
Regarding criticism from some session attendees that the agreement creates too many burdens for importers, Ley was a bit fatalistic but optimistic for the long term.
"This is not about fair," Ley said. "It's about what it is."
Despite the challenges the new suspension agreement may pose for shippers and importers, Ley said Mexico's tomato industry has a track record of using regulatory requirements as an incentive to modernize and improve its practices.
"I'm convinced it's going to make Mexico better," he said of the new regulations.


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Martin Luther King Jr. Holiday Schedules for Fairfax County
Fairfax County Office of Public Affairs
12000 Government Center Parkway, Suite 551
Fairfax, VA 22035-0065
Contact: Merni Fitzgerald, Director of Public Affairs
703-324-3187, TTY 711, Fax 703-324-2010
Media Pager: 703-324-NEWS (6397)
Jan. 10, 2008
Martin Luther King Jr. Holiday Schedules for Fairfax County
Listed below are schedules for Fairfax County government offices and services for the Martin Luther King Jr. holiday on Monday, Jan. 21.
County Government – Closed
Courts – Closed. Courts also will be closed Friday, Jan. 18, in observance of Lee-Jackson Day.
Public Schools and School Offices – Closed
Libraries – Closed
Fairfax Connector – Regular schedule, but no service on Routes 595/597
FASTRAN – Not in service
Park Authority – Nature centers and historic sites will be open from 11 a.m. to 4 p.m.; Frying Pan Farm Park will be open 9 a.m. to 5 p.m., and its visitor center will be open from 10 a.m. to 4:30 p.m. (store will be closed); Green Spring Gardens will be open 9 a.m. to 4:30 p.m. (historic house will be closed); RECenters will be open.
Community, Teen and Senior Centers – Closed*
County Trash and Recycling Collection – Regular schedule; please have trash and recyclables properly set out by 6 a.m. to ensure collection. **
Recycling and Disposal Facilities at I-66 and I-95 – Open
* McLean Community Center will host Martin Luther King Jr. Day activities on Sunday, Jan. 20, from 3 to 5 p.m.; closed on Jan. 21. Reston Community Center Hunter Woods will be open from 9 a.m. to 9 p.m.; Lake Anne will be closed.
**Residents receiving trash and recyclables collection service from private collection companies should contact their service provider directly to learn of any schedule adjustments due to the holiday.
For more news and information, visit www.fairfaxcounty.gov/news.