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Efficacy and Safety of Intralesional Corticosterois in the Treatment of Vitiligo
Recruitment status was: Recruiting
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Drug: Triamcinolone Acetonide
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:
|Efficacy and Safety of Intralesional Triamcinolone Acetonide in Vitiligo: A Prospective, Double-Blind Randomized Controlled Trial
- Assessment of the degree of repigmentation based on the modified VASI score for each half. We will consider the treatment successful if there was ≥50% change in modified VASI score from baseline. [ Time Frame: 3-5 weeks after each treatment session ]
- Assessment of side effects in each half including atrophy, telangiectasia, hyperpigmentation and hypopigmentation using a severity scale as follows: 0=none, 1=mild, 2=moderate, 3=severe. [ Time Frame: 3-5 weeks after each treatment session ]
|Estimated Enrollment:
|Study Start Date:
|January 2013
|Estimated Study Completion Date:
|January 2016
|Estimated Primary Completion Date:
|October 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: A: Triamcinolone acetonide
Injections will be given within one half of a single vitiligo patch. The concentration of triamcinolone acetonide (TA) that will be used initially is 2.5 mg/ml. Dilution will be done using a bacteriostatic normal saline. Each half will receive injections with either TA 2.5 mg/ml or normal saline as a control. Only one investigator will know the intervention each half has received. If the patient did not show any evidence of repigmentation during the 3rd visit (i.e. after two injection sessions with TA 2.5 mg/ml) , the concentration of TA will be increased to 5 mg/ml. A total of 4 injections will be given over 4 visits. The treatment will be repeated every 3 to 5 weeks for a total of 4 treatment sessions.
|Drug: Triamcinolone Acetonide
Placebo Comparator: B: Normal saline
Bacteriostatic normal saline will injected into one half of the vitiligo patch.
Detailed Description:
Vitiligo is a chronic acquired disease characterized by well defined white macules and patches affecting the skin and mucous membranes. Mucocutaneous lesions develop secondary to selective destruction of melanocytes. It has a major psychosocial impact on affected patients. The etiology of vitiligo is largely unknown but more likely to be multifactorial. There are several theories on the pathogenesis of vitiligo including mainly the autoimmune, neurohormonal, and autocytotoxic theories. The autoimmune hypothesis has the strongest evidence with alteration mainly in the cellular immune response.
Diagnosis of vitiligo is usually made clinically. A skin biopsy is rarely needed for diagnosis and typically shows absence of melanin in the epidermis with no or few melanocytes. Perivascular inflammation has been found in approximately 92% of cases. Spontaneous repigmentation is uncommon (seen in 10-20% of patients) in vitiliginous patches but can occur. Repigmentation occurs usually in a perifollicular pattern, suggesting that the hair follicle functions as a reservoir for melanocytes.
There are many treatment modalities available for vitiligo, however, none of them cure the disease. These include different topical treatments, phototherapy, surgical therapy, and depigmentation therapy. Topical corticosteroids (CS) are commonly used as a first-line therapy for localized vitiligo. They are the most effective monotherapy for localized vitiligo. Studies have shown an increase in inflammatory cells in vitiliginous skin, mainly macrophages and T cells. Efficacy of CS in vitiligo is attributed to modulation of the immune response, reduction of destruction of melanocytes, and induction of melanocyte proliferation and melanin production. Treatment with intralesional corticosteroids (ILCS) is commonly used in many dermatologic conditions. There are only a few studies published on the use of ILCS in vitiligo. Triamcinolone acetonide (TA) is the most commonly used form of ILCSs. It is characterized by low solubility, being slowly absorbed from the injection site, prompting maximal local action, limiting diffusion and spread through tissue, and not giving rise to systemic side effects if used in therapeutic doses. The concentration that is most commonly used in dermatology is 2.5 mg/ml.
Side effects of intralesional TA (IL TA) include pain at the injection site, mild bleeding, transient atrophy and telangiectasia, hypopigmentation, and hyperpigmentation. Infection is uncommon but caution over bony prominences is recommended. It has been shown that TA at a total dose of 20 mg does not result in adrenal suppression. Hypersensitivity reactions to TA or the vehicle carboxymethylcellulose are extremely rare.
The investigators' hypothesis is that IL TA will induce significant skin pigmentation to improve vitiligo. This due to the anti-inflammatory effect of IL TA. IL TA has been successfully used in the treatment of many skin conditions with an autoimmune pathogenesis including alopecia areata. The investigators plan on conducting a prospective double-blind randomized clinical trial to assess efficacy and safety of IL TA in the treatment of vitiligo.
Study Objectives
- To evaluate the potential for IL TA to induce repigmentation within vitiligo patches.
- To assess the side effect profile of IL TA when used in the treatment of vitiligo.
|Ages Eligible for Study:
|19 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age > 18 years.
- Localized or generalized vitiligo that involves a non mucosal or acral site.
- Patients should have a patch of at least 5 cm in the smallest diameter that shows no more than 10% repigmentation as assessed visually
Exclusion Criteria:
- Patients who received treatment for vitiligo within the past 4 weeks.
- Hypersensitivity to TA or vehicle.
- Pregnancy or breast-feeding.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01766609
|Contact: Harvey Lui, MD, FRCPC
|16048754111 ext 68691
|Canada, British Columbia
|The Skin Care Center, Vancouver General Hospital
|Vancouver, British Columbia, Canada, V5Z 4E8
|Contact: Harvey Lui, MD FRCPC 16048754111 ext 68691 firstname.lastname@example.com
|Principal Investigator: Harvey Lui, MD FRCPC
|Principal Investigator:
|Harvey Lui, MD, FRCPC
|University of British Columbia
|Responsible Party:
|University of British Columbia
|ClinicalTrials.gov Identifier:
|NCT01766609 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 9, 2013
|Last Updated:
|June 30, 2015
Keywords provided by University of British Columbia:
Vitiligo; Intralesional; Triamcinolone acetonide
Additional relevant MeSH terms:
Pigmentation Disorders
Skin Diseases
Triamcinolone hexacetonide
Triamcinolone Acetonide
Triamcinolone diacetate
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Immunosuppressive Agents
Immunologic Factors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
ClinicalTrials.gov processed this record on September 25, 2017


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Of the some 2 million men who fought for the Union during the American Civil War, more than 2,000 of them hailed from Portage County.
In a new documentary to commemorate the 150th anniversary of the Civil War, "The 'Sojer Boys' of Portage County," Kent State University's Fred Endres reveals the innermost thoughts and feelings of seven young men who were involved early on in the conflict.
The production will premiere at 10 p.m. Sunday on Western Reserve PBS (WNEO 45/WEAO 49).
"It's not a military history, or even a cultural history," said Endres, a professor-in-residence in the School of Journalism and Mass Communications. "The documentary follows seven young men through the war, from their enlistment, through their rudimentary training, to the boredom of camp life and to the horrors of the battlefield."
A number of soldiers referred to themselves as "sojer boys," hence the title. Some were enlisted for a period of three months, and some for three years. Some were married with children and others were single. Some of them were blacksmiths and teachers and the rest were farmers. Some survived the war, and some didn't.
"I have always been a student of the Civil War, but most of the early histories focused on the important generals or national politicians," Endres said. "Some of the recent books and documentaries looked more closely at the individual soldiers, but not enough. So, I wanted to do a real micro-history."
Endres used letters and diaries of soldiers, photographs they left behind as well as writings and reminisces of their friends and families to take a more personal look at the war.
"The program involved a lot of planning and research," Endres said. "From finding out about the lives of soldiers, to finding their letters and diaries, to fitting them into the chronology of the war. Then finding hundreds of photographs, musical pieces and sound effects, plus all the editing and production."
Endres admitted that after two years of producing the documentary, it became a very personal and emotional project.
"I got to know my seven soldiers very well," he said. "It's probably the most emotional story I've ever tried to tell."
Endres recalls one story that stood out to him the most.
"Adam Weaver, a young man from Franklin Mills, now Kent, survived a bloody, five-hour battle at Franklin, Tenn. in 1864," Endres said. "Thousands of men were killed, wounded or captured. After the battle, he was sent out onto the battlefield to look for the wounded. His reactions are extremely realistic and emotional. After surviving that major battle, he ends up marching through a swamp in North Carolina and he is shot in the thigh. Surgeons wanted to amputate his leg, but he begged them not to do it. He survived, walked with a limp the rest of his life, but kept his leg. His great-granddaughter, Jackie Weaver Woodring, lives in Brady Lake, and tells that story in the documentary."
Endres said he wants people to see the Civil War through the eyes of the soldiers.
"I want them to understand what it was like to be a common soldier in this long, unusual war," Endres said. "The highs and lows, where they acted bravely and where they acted, perhaps, inappropriately."
Students from Kent State and the University of Akron were also invested in the documentary. They helped with research and planning, uncovered photographs and recorded comments from the soldiers and nurses' diaries and letters.
One of the student researchers was Philip Shackelford, a history student at KSU.
"Initially, I was involved primarily as a researcher, hunting down sources, tracking events and people and searching for the necessary evidence that would support observations made in the film," Shackelford said. "We also studied historical records to obtain information about various questions, like muster rolls, regimental histories and newspaper articles from the 1860s to place our observations in historical context."
Shackelford said being involved in the documentary has been a surreal experience.
"For 150 years, these stories have, for the most part, been preserved only in the family accounts passed down through the generations," he said.
Shackelford said he didn't expect to know the soldier as well as he does now.
"They hated leaving their homes and families, worried about their first battle experience and complained about the food and the long marches," he said. "Like our soldiers today, they were conflicted about the war itself and felt that having to kill other human beings was repulsive, but felt a strong sense of duty to protect and fight for the Union they loved so well."
Shackelford said his research for the documentary has given him a newfound appreciation for history.
"Instead of having to see the big picture all the time, the personal stories of local players in such an important event are often the most compelling," he said.
Shackelford said he hopes the audience will set aside any pre-conceived notions and misconceptions that surround the Civil War History and listen to the personal testimony of the soldiers themselves.
"I hope they take away what the characters themselves have to say," Shackelford said. "The Civil War was an event that changed the course of American history, yes -- but it was at the same time a very tragic, intense and life-altering struggle. One can hardly imagine the resolve, dedication and bravery that characterized the people who fought the war, both North and South."

subset: commoncrawl


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POOL: Decisive blow in title race
10:00am Thursday 30th January 2014
By Andrew Simpson
10:00am Thursday 30th January 2014
By Andrew Simpson
CHAMPIONS Rudheath landed a likely decisive blow in a fight to win the Northwich and District League title after beating their closest rivals last Wednesday.
Fred Backhouse and Matty Hubert both cued maximum breaks for the Division pacesetters in their head-to-head with Gladstone C, who won a single frame.
It leaves them 18 points from the table's summit with only half a dozen matches left.
Barn Owl D will hope to pinch second spot from the newcomers, moving to within five points of a runners-up position following a 5-2 defeat of back-markers Barn Owl B.
Gladstone B rise to fourth after a comfortable 6-1 win at Bowling Green A, while in-form The Elms – victors now in their past three matches – moved further from the relegation zone after proving too strong for their guests Green Dragon A.
Owley Wood A lost for a fourth successive week, this time at Gladstone A.
Hartford B's advantage at the top of Division Two is a dozen points following their latest success, this time at Witton Chimes.
Meanwhile Hartford A's sequence of five straight wins ended at home to Bowling Green B, meaning they cede second spot to Greenbank A who were awarded a 7-0 victory against Slow & Easy after the Lostock Gralam-based outfit conceded their scheduled encounter.
Castle Private's hopes of joining the race for promotion were hit after a 4-3 reverse at Owley Wood B, while Wheatsheaf edged neighbours Owley Wood C in the other match played.
In Division Three, Lion Moulton moved to within two points of leaders Chapels – without a match this week – following a 5-2 defeat of Greenbank B.
Martyn Rowlands' maximum break was a highlight of their win.
Blue Barrel are close behind them in third position, and with a game in hand, after narrowly squeezing past Beech Tree A by the odd frame.
Nathan Walker potted all eight balls from a single visit to the table in his frame win for the victors, while skipper Darren Penny kept calm to edge a decider.
Barn Owl E were the section's other victors at the expense of lowly Davenham Legion.
© Copyright 2001-2017 Newsquest Media Group


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Prof. Timothy S. Jost
Institute of Medicine Report on Conflicts of Interest
Listen to Prof. Jost explain some of the goals and innovative approaches contained in the IOM report.
Timothy S. Jost, the Robert L. Willett Family Professor of Law at Washington and Lee University and a health law expert, served on the 17 member group who produced the report. Jost was the only lawyer on the report committee.
Among its many suggestions, the report urges complete disclosure in a national database of monetary exchanges between doctors, institutions and drug and medical device companies that could lead to conflicts of interest. The report also recommends that drug companies stop giving gifts of any kind to physicians.
"There is considerable evidence that even small gifts influence judgment," says Jost. "Doctors should be exercising judgment for their patients, not for the profit of pharmaceutical companies."
Media coverage of the IOM report is available at the links below:
Jost has served as a visiting scholar at the Institute of Medicine and has authored or reviewed several other reports issued by the organization, which is part of the National Academy of the Sciences. He is a co-author of the casebook Health Law, used widely throughout the United States in teaching health law, and of a treatise and hornbook by the same name. He is also the author of Health Care Coverage Determinations: An International Comparative Study; Disentitlement? The Threats Facing our Public Health Care Programs and a Rights-Based Response; and Readings in Comparative Health Law and Bioethics. His most recent book is Health Care at Risk: A Critique of the Consumer-Driven Movement from Duke University Press.


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Frosted Zucchini Cookies Recipe
5 3 4
Friends and family gladly share garden-fresh zucchini with me so I can make and give away many batches of these cookies. I keep shredded zucchini in the freezer so we can enjoy them in winter as well. A cream cheese frosting makes them especially delicious.
Recommended: Our Most-Loved Recipes for Zucchini
VERIFIED BY Taste of Home Test Kitchen
- 1/2 cup butter, softened
- 1 cup sugar
- 1 egg
- 2 cups all-purpose flour
- 1 teaspoon baking soda
- 1 teaspoon ground cinnamon
- 1/2 teaspoon salt
- 1/4 to 1/2 teaspoon ground cloves, optional
- 1 cup finely shredded zucchini
- 1 cup raisins
- 1 cup chopped walnuts
- 1/4 cup butter, softened
- 1 package (3 ounces) cream cheese, softened
- 1 teaspoon vanilla extract
- 2 cups confectioners' sugar
- In a large bowl, cream butter and sugar until light and fluffy. Beat in egg. Combine the flour, baking soda, cinnamon, salt and cloves if desired; add to creamed mixture alternately with zucchini, beating well after each addition. Stir in raisins and walnuts. Cover and refrigerate for 2 hours.
- Drop by heaping teaspoonfuls 2 in. apart onto lightly greased baking sheets. Bake at 375° for 12-15 minutes or until lightly browned. Remove to wire racks to cool completely.
- In a small bowl, cream butter, cream cheese and vanilla until fluffy. Gradually beat in confectioners' sugar until smooth. Frost cooled cookies. Yield: about 5 dozen.
Originally published as Frosted Zucchini Cookies in Best of Country Cookies 1999, p22
Reviews forFrosted Zucchini Cookies
My Review
Click stars to rate
Any changes to your rating or review will appear where you originally posted your review
Average Rating
Reviewed Aug. 4, 2014
"Love this recipe. Wow! Great tasting cookies. So Happy I found this recipe. Made just like recipe, would not change a thing. Can't wait to share with my friends. Thank you so much for sharing. Glad I made a double batch. Yum!!!!"
Reviewed Aug. 2, 2012
"Very good, the frosting really adds to the cookie. Made 2 batches. They freeze well too."
Reviewed Aug. 16, 2011
"I have made zucchini cookies before but these are by far the best! They were the perfect texture - a tad bit crispy on the outside but basically soft throughout. Though I did make the frosting, after trying a bare cookie, I decided it didn't need it. Very yummy!"


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Up to 50% off Sitewide @ PETCO.com
Free Shipping on $49+
Expires On: Nov 25, 2012 11:59pm
Excludes products with Manufacturer Minimum Advertised Price and Live Reptile Food.
Discount on food, litter, and flea & tick control is up to 10% Sitewide.
(FatWallet Deal Hunter staff posts are certified ad-free. No money, bribes, or candy have been accepted.)


text:
Roll Over Image to Zoom
Dunes Tie-Dye Quilt + Sham, Navy
No longer available
- Overview
The natural ripples and soft curves of sand dunes are reinterpreted in retro style on our hand-quilted bedding.
- Made of 100% cotton percale.
- Filled with polyester batting.
- The fill in our quilt is made of 40% recycled materials. Each quilt saves 30 plastic bottles from reaching the world's landfills.
- Pre-washed for added softness.
- Features a swirled tie-dyed design.
- Quilt and sham reverse to solid cotton percale.
- Quilted sham has an envelope closure.
- Twin-sized quilt fits both standard twin and twin XL dorm mattresses.
- Quilt, sham and insert sold separately.
- Machine wash.
- Imported.
Mix + match our bedding to create your own unique look with our Design Your Own Bed Tool.
- Dimensions + Care
- Twin: 68" x 86"
- Full/Queen: 86" square
- Standard: 20 x 26"
- Euro: 26" square
- A percale weave is noticeably denser and wears well over time.
- Quilt filled with 320-gram-weight polyester batting.
- Sham filled with 220-gram-weight polyester batting.
- Machine wash in warm water, gentle cycle.
- Use only nonchlorine bleach, if needed.
- Tumble dry on low heat; remove promptly.
- Warm iron as needed.
- Shipping Info
This item will arrive in 3-5 business days. Please proceed to the Payment & Review page of Checkout for a precise delivery estimate.
No longer available
Standard Sham (Sold Separately)
No longer available


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There will be a new Crystal Palace player towering over the South Circular soon and it will be up to fans to decide what the strap line will be.
After the success of the Wilfried Zaha 'He's just too good for you' billboard campaign, Crystal Palace FC have decided the club's midfield general Mile Jedinak will be the new face on the billboard.
The six metre by six metre poster, part of the club's South London and Proud campaign, was created by the club's design department.
It is situated at the cross roads between Streatham Hill, Brixton Hill, Streatham Place and Christchurch Road.
The club have asked fans to submit their headline ideas before Monday January 15 with the winning entry being emblazoned across the new billboard.
Fans can enter by visiting the club's Facebook page, cpfc.org, Holmesdale.net or send an email to email@example.com.
Co-chairman Stephen Browett said: "Following on from the enormous publicity generated by previous "South London and Proud" billboard campaigns we thought that it was time to do another.
"The Wilfried Zaha poster on the South Circular has been seen by thousands of people but it's time for a change so naturally we thought of featuring our captain who has been in such fantastic form this season."


text:
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If you take the time to help us out, there is a good chance we'll send you a FREE Disc.


text:
I've just came back from a trip to a Buddhist monastery, which I enjoyed very much.
For the morning and evening chanting prior to the meditation session, the advice of the monk to people unfamiliar with chanting in Pali was simple: "fake it until you make it". This worked quite well, and after a few days I sort of memorized the stress patterns for some of the simpler chants.
However, I would like to know whether chanting in Pali follows any sets of principles, in regards to stresses and pronouncing some of the syllabus longer/shorter, or is it all memorized by people in the course of practicing?
Thank you.


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ARE there honestly fans who believe Newport County AFC lack ambition for selling Conor Washington?
Is it truly a reality that some supporters feel the club have somehow betrayed them by selling a prized asset for the fourth time in four seasons?
If there are, they couldn't be more wrong, nor could they be more naive as to the reality for a newly promoted Football League club. And I'm pretty sure they'd be in a tiny minority.
County have played an absolute blinder with the Washington deal, learning from past mistakes, doing right by the player and finally finding the courage in their conviction to play hardball.
Let's deal with the brass first, the hard cash County will receive for Washington and how it leaves them in regards to the remainder of the campaign.
Firstly, we see some massive differences between this move and the proceeding three big January deals that saw Craig Reid, Danny Rose and Lee Evans depart in 2011, 2012 and 2013 respectively.
No leaks. No negotiations largely debated and scrutinised in public, making the Exiles look amateurish, instead County kept their negotiations with Peterborough secret for an entire fortnight before Posh leaked the news to Sky Sports in sheer desperation at Newport refusing to budge from their valuation.
Tim Harris and Barry Fry spent two weeks locked in negotiations with Fry finally reaching the mark County wanted with a call to Harris early on Saturday. By the evening, the deal was concluded.
The Exiles have also finally realised it's a slap in the face to fans to not reveal the details of the deal (a topic I've moved about yearly). While they wisely won't announce how much they got up front (it's a sellers' market when you reveal your 'war chest') they have made clear that the best case scenario – with incentives based on the move being successful – will net them in excess of £500,000.
And that's before we mention a sell-on clause. My understanding is that Newport have secured a clause that significantly exceeds the usual five or 10 per cent and that was their key objective.
That means if Peterborough sell Conor Washington for a fee similar to the one they received for Dwight Gayle, County will be quids in, bagging over £1 million.
That's a game-changing figure for a League Two club, especially one with Conference financial figures dictating their wage budget under Football League jurisdiction, and is all the more staggering when you consider Washington is yet to even hit double figures this term.
We are not talking about a scoring sensation here. We are not talking about an irreplaceable goal record as we were with Craig Reid.
Washington's total goal contribution this season is replaceable. Washington, as he is today, will be missed, but it's not comparable to the huge loss created when Reid and Rose left Spytty Park.
Peterborough are buying potential and Newport have got a fantastic price for a player who is unproven and cost them just £5,000 15 months ago.
However, County, like me and like Peterborough, believe Washington is a future Premier League player. They were disappointed to hear from Posh in the first place and equally so when Washington made it clear that he wanted to head to the League One hopefuls.
They fought hard to ensure proper compensation and late in the day they even as Fry described it, "moved the goalposts," by also landing Shaun Jeffers as part of the move.
The Exiles told Peterborough no move for Washington would be sanctioned without a replacement being found first and Jeffers was the only player from London Road Justin Edinburgh was keen to be used as a makeweight.
Already a minority of fans are unfairly making comparisons to when Yemi Odubade and Charlie Griffin came as part of the deal that took Reid to Stevenage.
That's a nonsense. Odubade wasn't wanted by Stevenage and Griffin was well past his best. In this instance Newport have received a player Posh wanted to keep and who at 21 is far from his peak.
On Friday, with the deal still being negotiated, a League One club and a League Two promotion chaser registered an interest in Jeffers and that also threatened to delay or scupper Washington's big move as Newport by that stage insisted on the ex-Coventry man being included in negotiations.
Thankfully, the move was completed and all parties can now move on fully satisfied with their deals.
The Exiles receive a record fee, a replacement and can hope Washington fulfils the potential they see in him as they'll again be financially compensated should he continue his rapid rise.
Peterborough acquire some firepower and a genuine hometown hero as they bid to get their campaign and Championship ambitions back on track and Washington can return home and attempt to shine at a higher level on a bigger stage.
Everyone is a winner in this instance and though it's a real shame to see such a bright prospect moving on, County have done unbelievably well to make such a profit on Washington in such a short space of time, 15 months.
He leaves with best wishes from all and has grown not just as a player but as a person in his time with Newport. The shy former postman unsure of himself in a professional environment is now a proper player and a very nice guy.
For once, it's impossible to be critical.
I'M equally firm in my view that Newport County's promotion aspirations are still alive and well despite their customary wobbly start to the New Year.
It seems postponements and irritating results against relegation fodder and/or local rivals is very much the usual for County in January, the only month of the year where Justin Edinburgh seems to become a mere mortal who is occasionally even fallible to mistakes and misjudgements.
Newport have lost touch with the top seven and are facing a backlog of games in the business months.
That doesn't worry me.
By the time the games come thick and fast, Newport's squad will include the likes of Byron Anthony, Max Porter, Chris Zebroski and Aaron O'Connor and the likes of Christian Jolley and Lenny Pidgeley, key players with great pedigree, will be in better form.
Whereas last year Newport's backlog meant more travelling than Judith Chalmers did in the 90s, this term they'll mainly be making the games up at fortress Rodney Parade with big crowds and thumping atmospheres and can continue to have one of the best home records in League Two.
I find it absolutely staggering that in a minority of fans' eyes, the players are now being found out, having overachieved, so far this season.
What a perverse logic. County have underachieved since their good win at Wycombe Wanderers on Boxing Day and have had a wobbly couple of weeks. But throughout the campaign they've been consistent and almost always competitive.
Their current arrears from the top seven in retrievable in a couple of games. If the Exiles fall 10 or more points off the pace, I think gloom might be somewhat justifiable.
But right now? The Exiles would almost certainly make the playoffs if they can merely match their form in 2013.
Other than being light a central defender in the absence of Ismail Yakubu and Anthony, neither of whom can be relied upon indisputably in terms of injuries, the squad is very strong.
With a brilliant manager and a more than competitive group of players, now is an absolutely insane time to be dismissing the County and thankfully, I think only a handful are.


text:
Moderators: Timko, Fritz, Solty, Booter, Blake_T, Frank Delicious
Frank Delicious wrote:Every groove is a unique snowflake of suck.
veganray wrote:kern9787 wrote:Depending on what kind of data you have on there, my first instinct is always to nuke it and reinstall the OS.
This is a good solution. A better solution: throw it in the dumpster & buy a Mac.
swel304 wrote:I would nuke and reinstall but the disc that came with the pc doesn't seem to be bootable.
kern9787 wrote:That's a mac users solution to everything. Upgrade? Dumpster + new computer.
Ryen91 wrote:I am pretty sure I am more intelligent then you think and have allot more knowledge then your post might suggest.
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text:
What does sustainability mean to you?
To me sustainability means living closely with the earth. It means acknowledging that we live on a beautiful planet and wanting to keep this planet beautiful for as long as possible.
What are you doing to help UB become more sustainable?
I am involved in many different on campus organization focusing on the environment. I am the former co-service chair of Alpha Kappa Chi, the environmental fraternity on camps, and I am the upcoming secretary for Alpha Kappa Chi. I am lightly involved with a couple projects with engineers for a sustainable world and I am also one of the student leaders for the Campus Garden Initiative.
How do you involve UB's faculty or staff in your sustainability work?
Every professor I've ever met at UB wants to help you and watch you succeed. Many are also just as committed to creating a sustainable campus as the students. Every project I've ever worked on has been backed by amazing faculty who want change just as badly as the students working on the projects.
How has sustainability impacted your academic pursuits?
Sustainability has taught me how I want to live my life and what kind of things I want to keep getting involved with in the future. As an environmental engineering major I'm hoping to become involved in different kinds of habitat restoration projects as well as water treatment projects. My immediate goal is to join the Peace Corps after college and bring sustainable practices to other countries.
What is the one thing you would like people to know that you do in your personal life to further sustainability?
I try to make sustainable actions a normal for my life. My goal is for it not to be thought of as sustainability, but just as something normal that's done every day. I bring my reusable water bottle to school every day because buying a plastic bottle is not even something that's on my radar as an option. I recycle because that's just the way the trash needs to be sorted. I don't want it to be thought of as acting exceptionally but rather just acting as you should.
How could UB improve its sustainability efforts?
First off, UB bottle free is a must. If you haven't heard
of it check it out on Facebook and sign the petition. There is no
reason for plastic water bottles to be sold on this campus.
Secondly, I think there's a lot that could be done to
conserve electricity on campus. Anyone who's walked around at
night knows how many unnecessary lights are on in every classroom
and lecture hall. Thirdly, I think UB should strongly consider
adding an environmental issues class as a general education
requirement. Environmental problems are happening now all over the
country and all students should be educated about them.


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Field manager Steve Vickers hailed his side's "incredible season" after they clinched the treble at Elland Road.
A four-goal first-half blitz saw them cruise to a 5-2 victory over Steeton in the West Riding County FA Challenge Cup final.
Having already won the Bradford & District FA Sen-ior Cup and the West York-shire League Cup, the Bradford side's triumph capped a memorable campaign.
Vickers, who is in his first year at the helm having previously coached the under-19s, said: "I am so proud of our achievement.
"Winning the ultimate prize of the County Cup is the icing on the cake and the atmosphere at Elland Road was unbelievable.
"The lads have shown a great attitude in what has been an incredible season."
Field raced into a 3-0 lead inside 14 minutes against their opponents from the West Riding County Amateur League.
Skipper Darryl Leach bundled the ball in for the first from close range and the Chevrons' failure to deal with another corner saw Glyn Hirst apply the finishing touch for the second.
A long punt up field was then met by the head of Chris Wood and his looping effort sailed over goalkeeper Phil Rishton to make it 3-0.
It looked all over for Roy Mason's men as Graham Holmes was adjudged to have handled in the box and John Penn made it 4-0 from the penalty spot.
This sparked Steeton into life as Andy King found Lee Reilly, who neatly lobbed the keeper to reduce the arrears.
Within a minute, Reilly had cut the deficit further as he was felled in the box and he dispatched the penalty.
However, just before half-time Andy Holden was sent off for retaliation after being hacked down, leaving Steeton with a mountain to climb.
The killer blow from Field, who lifted the cup for the first time, came in the form of a spectacular strike from Josh Milner after 57 minutes following a great move.
Steeton finished with nine men after Matt Kershaw was dismissed for dissent.
Vickers said: "To go 4-0 up – we couldn't have dreamt of that start. Then we dominated the second half and saw the game out.
"Credit to Steeton – they were very complimentary to us after the game. Both sides made it an enjoyable occasion."


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Grab a bowl of popcorn and pull up a chair, two news reports surfaced this weekend pointing to Rush Limbaugh's deal with Cumulus in jeopardy, possibly leading to the biggest shakeup in talk radio history. We wrote about Rush Limbaugh causing the company's revenues to plunge from fallout after he called Georgetown University law student Sandra Fluke a "slut."
Rush Limbaugh insists it's not his fault that ad revenue has dropped at his flagship WABC radio station — and if his boss keeps saying it is, Rush just may pack up his megadittoes and leave…
Lew Dickey, the CEO of WABC parent company Cumulus, has said Limbaugh's controversial comments have diminished ad revenue for the past year — and the slump remains a "residual hangover" for the station.
The timing of the Cumulus-Limbaugh dogfight is damning:
Cumulus Media, which has a contract with Limbaugh through 2013, declined to comment for this report: "Cumulus owns the premier talk radio distribution platform in the United States and doesn't comment on negotiations with talent under contract," Davidson Goldin, a Cumulus spokesman, told POLITICO. Clear Channel, which distributes the Rush Limbaugh Program through its Premiere Radio division, also declined to comment.
The news of Limbaugh's possible departure comes one day ahead of Cumulus's Tuesday earnings call, at which Dickey Is once again likely to address the impact the Fluke controversy has had on advertising. The source close to the show described Dickey's remarks about advertising revenue as unjustified, and said such "criticism" of Limbaugh had resulted in the consideration to leave the company.
Um, I don't think too many people will feel much sorrow if this right wingnut is dropped by Cumulus. There comes a point when the company realizes that the backlash over Rush Limbaugh's comments isn't worth watching its bottomline disappear into thin air. If true, I can only say echo Miss Sofia from "The Color Purple," who said, "I know'd there is a God. I know'd there is a God!"


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Video: NAD C 356DAC stereo integrated amp
Tara W. has worked for Crutchfield since 2004. She writes about whole-house music and video gear, and works on Crutchfield's video team.
More from Tara W.
Heads up!Welcome to this article from the Crutchfield archives. Have fun reading it, but be aware that the information may be outdated and links may be broken.
NAD has created something exciting with their new C 356DAC stereo integrated amplifier. They've taken one of their popular mainstays, the C 356BEE integrated amp, and added a world-class DAC so that you can treat all your digital sources to the power and control that has made NAD legendary among audio enthusiasts. Jeff from NAD visited Crutchfield and told us all about it.
Video Transcript
Tara: We're here with Jeff from NAD talking about their 356DAC.
Jeff: Yeah, the 356DAC is a really sort of new idea from NAD. We offer the 356BEE model number. It's an integrated amplifier, 125 watts a channel from NAD. Strictly analog, so it's good for all the analog components that you have. And we offer it with what's called an MDC, modular design construction DAC, digital-analog converter, separately. The two can be combined. However, it's not really consumer friendly in that aspect, so what Crutchfield will be selling is the 356DAC, already done by NAD at the factory. So in the box you'll already have the DAC installed, ready to go, at an incredible savings if they were purchased separately. So it's a very cool idea.
Now, the whole purpose of the DAC is to allow end users to bring in digital audio, specifically the computer audio which is becoming very, very popular of course. So the DAC has two inputs. One asynchronous USB for 24/96 high resolution audio, and the other optical, which can handle up to 24/192 audio, and that's more specifically for computers. Most consumer audio gear doesn't really output that for optical, but many computers, Macs, specially tuned Windows computers can do that. And obviously asynchronous is standard across all the computer platforms.
So you have an analog integrated amplifier that can drive just about any speaker that Crutchfield sells, whether it's a low impedance or high impedance, it doesn't matter because it uses NAD amplifier technology that goes back forty years, as well as being able to integrate new digital inputs, especially computer audio.
Tara: If you have any questions about audio components, just give us a call.


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Kingfisher Bay Resort (KBR - incorporating the 152-room Mercure Kingfisher Bay Resort hotel), Eurong Beach Resort (EBR), Fraser Explorer Tour (FET) and Cool Dingo Tour (CDT) programs are designed to provide enjoyable nature-based tourism experiences on Queensland's Fraser Island.
KINGFISHER BAY RESORT: Rolling Resort Refurbishment Program
KINGFISHER Bay Resort will roll out a full refit for the 120-seat Maheno Buffet Restaurant and Lounge Bar by the end of July. The resort's rolling refurbishment program has seen the conference area, Centre Complex and pool areas upgraded recently. In the conference area, high tech AV equipment, lighting, sound-proof walls as well as soft and hard furnishings has brought the resort in line with current industry standards. The resort's jetty and access roads are currently being upgraded.
KINGFISHER BAY RESORT: Fraser Island Is China Ready
AN INTERNATIONAL Sales team from the world's largest sand island is targeting the world's most populous country – China – with an aggressive sales and marketing plan designed to lure Asian tourists to World Heritage-listed Fraser Island.
Kingfisher Bay Resort's Director of Sales and Marketing, Kerry Brough, said the time was right to debut their suite of Fraser Island products to appreciative Asian audiences. As the fastest developing market, Mrs Brough said China presented a fresh growth opportunity for their Fraser Island products, in both the leisure and group series business.
In the past six months the resort group has rolled out Chinese marketing collateral and Mandarin MP3 commentary machines on Fraser Island day tours; has developed a special menu for Asian groups; has run cultural training sessions for staff; has employed Mandarin and Cantonese-speaking staff at the resort; has launched a WEIBO social media site and blog; and has distributed Chinese brochures. A Chinese version of the resort's website is also currently in development.
Mrs Brough said the lynchpin of the resort group's own strategy for Fraser Island was the appointment of Laurel Zhang into the Asian Sales Manager role last year. Laurel, who is proficient in Cantonese, Mandarin and English, is responsible for developing the FIT and accommodation business in China, Taiwan, Hong Kong and South-East Asia.
KINGFISHER BAY RESORT: New Guest Activities On Fraser Island
WHILE the big boys are roughing it in 4x4s on Fraser Island's sand tracks; Kingfisher Bay has introduced an all new, eco-friendly adventure for guests in the form of all-wheel-drive Personal Segway transporters.
The Ranger-guided Segway PT adventure sessions use the latest in green technology – the fully electric Segway Personal Transporters – to manoeuvre their way along the intertidal zone and across the beach terrain on the western side of the island with a Resort Ranger. The resort has also introduced thirty-minute 'Let Loose' sessions for those who want to explore on their own. Whilst some restrictions apply (like height and weight), the sessions are open to guests over the age of 12.
In addition to the popular Ranger-guided canoe paddles and fishing clinics, the resort has also partnered with the crew from Freedom III to deliver a range of cruise products – the morning adventure cruise with dolphin/dugong search; a sunset cruise with drinks and nibbles; a fishing experience with gear and bait supplied; and a Great Sandy Cruise for group bookings.
The Resort's Jetty Hut has also expanded the activity schedule and offers Stand Up Paddle Boarding and for those less inclined to hit the water – a range of gorgeous bush-inspired canapés and platters at sunset.
KINGFISHER BAY RESORT: New Flames Of Fraser Dining Experience
FRASER Island takes centre stage in an all-new, intimate dining experience for guests at Kingfisher Bay Resort. Aptly named 'Flames of Fraser', resort guests will be treated to an indulgent five-course, bush tucker-themed menu, Queensland wines and the sounds of Fraser Island by firelight in the heart of the resort's Wallum heath.
The evening starts with sparkling wines and canapés as Sunset Beach, before guests walk barefoot to their outdoor dining room, where the resort's Executive Chef has crafted an indulgent five-course, native table d'hote menu.
Moreton Bay Bugs with Lemon Myrtle; Crocodile San Choi Bao with Betel leaves and Bunya Nuts; and Kangaroo with a bush tomato relish feature alongside an Australian favourite – petit pavlova served with wattle seed ice cream – on the bush-inspired menu.
Queensland wine makers, like the Granite Belt's Robert Channon, also make cameo appearances on the wine list. Fire pits, indigenous music and a local story teller round out the four-hour outdoor dining experience on Fraser Island's western side, which finishes with a digestif in the resort's signature restaurant, Seabelle.
Flames of Fraser dinners run on Mondays, Wednesdays and Friday nights and are priced at $149pp and bookings are essential.
FRASER EXPLORER TOURS, COOL DINGO TOURS & KINGFISHER BAY RESORT: Foreign Language Guides Available On Fraser Island Tours
GERMAN, Korean, Japanese, Italian, Spanish, Chinese, Simplified Chinese and English visitors will be given a taste of home on Fraser Island, with the introduction of hand-held, foreign language, interpretive guides for all Fraser Explorer Tours (ex Hervey Bay and Rainbow Beach); Beauty Spots Tours (ex-Kingfisher Bay Resort); and Cool Dingo Tours (ex Rainbow Beach and Hervey Bay).
Group General Manager, David Hay, said he hoped the foreign language guide value-add to the tour would help visitors gain a greater understanding of Fraser Island's incredible natural environment.
"We have condensed the island's European and Indigenous history; stories of creation and sand formation; flora and fauna facts along with interesting facts and figures about the island's iconic sites into a digestible format – with bite sized pieces of information at each site," he said.
COOL DINGO TOURS: Departures Now Available Ex Rainbow Beach
FRASER Island's number 1 rated Cool Dingo Tour of Fraser Island now departs from Rainbow Beach as well as the regular departure from Hervey Bay.
Tour Manager Colin Anderson said the one very big advantage was the 3 Day 2 Night Tour offered a 'through fare' option – allowing guests the choice of starting their tour in Rainbow Beach and finishing in Hervey Bay or back in Rainbow Beach.
"The beauty of this new touring option is that time-poor travellers will not waste travelling time in either direction," he said. "The 2 Day 1 Night option departs ex Rainbow Beach and Hervey Bay, but because of itinerary configurations could only finish in Hervey Bay."
KINGFISHER BAY RESORT: New Conservation Credit Scheme
IT IS A little bit easier to be greener at Kingfisher Bay Resort with the introduction of a new Conservation Credit Scheme aimed at rewarding customers for helping the resort reduce its carbon footprint.
Under the Conservation Credit program, guests who choose not to have their rooms serviced will be rewarded with a $15 conservation credit (per room) to put towards a treatment at the resort's in-house Kingfisher Natural Therapy salon OR a full day guided eco tour of Fraser Island.
Guests can opt in by placing a biodegradable card on their door handle each night. Points are then redeemed at checkout off the cost of touring or treatments in the eco-friendly spa.
KINGFISHER BAY RESORT: Hervey Bay Humpback Whale Watching Season Splashes Down 1 August
HERVEY Bay's Humpback Whale Watch season runs from 1 August til the end of October with some of the most prolific whale spotting in Australia. Invariably during the season inquisitive humpbacks, referred to as 'friendlies', will approach whale-watching boats very closely, often staying under or near the boat for many minutes.
Half-day trips depart daily from Kingfisher Bay Resort from 0745 during the season (Aug 1 - 31 Oct). Accommodation and Touring packages start from $379 per person and include 2 nights' resort accommodation (and a bonus THIRD night free with breakfast for guests who have time in their itinerary), hot buffet breakfast daily; return passenger ferry transfers from River Heads and a half day whale watch cruise.
FRASER ISLAND: Makeover For Access Roads
ONE OF Fraser Island's most notorious unsealed access tracks – affectionately known as 'The Rollercoaster' by island locals - is set to get a major makeover under a joint collaboration between the Department of Environment and Resource Management (DERM) and Kingfisher Bay Resort this month.
Kingfisher Hill - a notorious 800 metre stretch of unsealed, rutted uphill track that provides direct access from Kingfisher Bay Resort into the Great Sandy National Park - will be tar-sealed in a major ten-week construction project starting in early May.
The road, which is on national park land, is the major thoroughfare for guests wishing to access Fraser Island from the western side and has attracted widespread criticism for the damage the rough conditions have caused vehicles. Conditions are so rough that current QPWS signage warns motorists of the dangers on both approaches to the stretch of road.
Kingfisher Bay Resort Group General Manager, David Hay, said it was a common misconception that Kingfisher Hill is on resort property. "Over the years, we've spent a lot of time and money maintaining it - so we're understandably thrilled with the decision to seal it and are supporting DERM's efforts by providing complimentary accommodation for workers and barge services during construction," he said.
FRASER ISLAND: A Natural Choice For Group Series Travel
FRASER Island and Kingfisher Bay Resort offer competitively-priced packages for group travel and educational study tours – talk to your Kingfisher Bay Group in-market representative for details.
KINGFISHER BAY RESORT GROUP: Quick News Snippets
THOMAS Schick will join Kingfisher Bay Resort Group International Sales Manager, Stephanie Siebert, in representing the interests of the Kingfisher Bay Resort Group for Germany, Switzerland, Austria, Belgium, France and Italy. Thomas will represent the group at consumer shows, trade fairs and agent events and will train major wholesale and retail partners.
Thomas founded his business, Pure Travel, back in 2004 to represent Australian tourism companies in the European market. His first client, back in 2004, was Apollo Motorhome Holidays and in 2006 he added Explore Whitsundays. Thomas has also represented Coral Sea Resort, Noosa Blue Resort and O'Reilly's Rainforest Guesthouse.
THE KINGFISHER Bay Resort Group has appointed Danae Schmid to oversee the group's education group program for Fraser Island. Group packages and itineraries are tailored to suit all ages from primary school to university and social groups. At resort level, Brett Libbis has been appointed Executive Chef at Kingfisher Bay Resort. Brett joins the Fraser Island team fresh from a two-year stint at Ayres Rock Resort where he oversaw 10 outlets, 100 chefs and stewards and the popular Sounds of Silence experience.
Editor's Notes: Why Fraser Island?
• FRASER Island was named the No 1'Favourite Australian Island Escape' by UK readers of The Telegraph's travel section (April 2013).
• NATIONAL Geographic has recently named Fraser Island as one of the World's Best Beaches, reporting: "This World Heritage site is an ecologist's dream with 640 square miles of unspoiled natural paradise. Rainforests with 1000-year-old trees sprout from the sand." The Queensland sand island was the only Aussie location to make the 2012 list.
• AUSTRALIAN Geographic listed Hervey Bay in the top ten places to Whale Watch in Australia; and The Courier Mail named Fraser Island as one of the 'Top Ten Best Getaway Drives in South East Queensland' (June 2012).
• LONELY Planet recently named Fraser Island in their Top Five Treasured Australian Islands (May 2012).
• THE Daily Times (UK) named Fraser Island's eastern beach in their list of the world's STRANGEST beaches... rainforest growing in sand; swimming in fresh water on an ocean beach; it's a gazetted highway; it's a landing strip for planes... we call that pretty awesome! (June 2012).


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MOUNT WASHINGTON - Local basketball fans can get a look at all three Bullitt County girls' basketball teams in one sitting on Saturday in the first Bullitt County Challenge event.
So-called 'showcase' events have become popular throughout Kentucky over the past few years. In these events, teams get together and play one game in a non-tournament format. Bullitt East will play in three of these style events in January alone.
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When Mark Twain first visited Hartford in 1868, it was love at first sight. He made the city his home for two decades. We hope you will fall in love with Hartford, too, when you add The Mark Twain House & Museum to your travel plans or vacation itinerary.
Located 20 minutes from Bradley International Airport, 90 minutes from Boston, two hours from New York and less than an hour from Interstate 95, Hartford is convenient and a destination unto itself. There are many things to do and see, so we hope you will linger and enjoy all that we have to offer.


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Scriptures read by: Arlene McKellar
Sermon: Pastor Mark Bankson
Newsletter October 2017
Calendar October 2017
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Listen to the entire Gospel of John read by Arnold Ronning. Click here
The office is open M - Th 9am - 3 pm except for holidays. Phone Messages may be left after hours.
Fourteen Stephen Ministers are commissioned to assist. Find out more about Stephen Ministries here. Click here
Men's Bible Study Fraternity going strong. Tuesday Mornings 7a.m.!
Please keep the Men's Fraternity in prayer as they stand for strong marriages, families and friends.
WOW is Worship on Weekdays for Kindergarten through fifth grade students on Tuesdays, 6 p.m. - 7:30 p.m. during the school year
Check WOW out here! Click below and get information about WOW. You can register a student or register to be an adult volunteer! Click here
Sunday School 9:45 a.m. will follow Stanwood School Schedule. For K-5 it's JAM (Jesus and Me) for 6-12 grades it's Donuts and Discussion.


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Pituitary Functions After Traumatic Brain Injury (TBI) and/or Subarachnoid Hemorrhage (SAH)
Recruitment status was: Recruiting
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Traumatic Brain Injury Subarachnoid Hemorrhage Hypopituitarism
|Study Type:
|Study Design:
|Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:
|Prospective Longitudinal Study on Pituitary Functions After TBI and/or SAH
|Estimated Enrollment:
|Study Start Date:
|September 2006
Recent data have demonstrated that hypopituitarism seems to be a frequent finding after traumatic brain injury (TBI) and/or subarachnoid hemorrhage (SAH). However, most of these studies referred to retrospective evaluations. There are only few prospective data, and no longitudinal study routinely taking into account the assessment of anterior pituitary function in the acute phase after TBI or SAH so far.
We prospectively evaluate pituitary functions in patients in the acute phase after TBI or SAH and a control group of patients with trauma not involving the brain. Endocrine data included basal anterior pituitary lobe hormone, IGF-1 and testosterone serum levels (Immulite 2000) within the first 8 hours after TBI or SAH. Further endocrine evaluation was performed by means of either a combined GHRH-arginine-CRH-LHRH test or an insulin-induced hypoglycemia test after 4 months and 12 months. To rule out an assay related bias with regard to GH and IGF-1, all hormone levels were cross-checked by a supersensitive assay in another laboratory.
|Ages Eligible for Study:
|15 Years and older (Child, Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- TBI or SAH
- Control group: injury without involvement of the brain/skull
Exclusion Criteria:
- Pregnancy
Please refer to this study by its ClinicalTrials.gov identifier: NCT00507104
|Contact: Juergen Kreutzer, M.D.
|Contact: Michael Buchfelder, M.D., Ph.D.
|Department of Neurosurgery, University of Erlangen
|Erlangen, Germany, 91054
|Study Chair:
|Michael Buchfelder, M.D., Ph.D.
|Department of Neurosurgery, University of Erlangen
|Principal Investigator:
|Juergen Kreutzer, M.D.
|Department of Neurosurgery, University of Erlangen
|Principal Investigator:
|Christioph Schöfl, M.D., Ph.D.
|Department of Neurosurgery, Division Neuroendocrinology, University of Erlangen
|Principal Investigator:
|Andrea Kleindienst, M.D.
|Department of Neurosurgery, University of Erlangen
|ClinicalTrials.gov Identifier:
|NCT00507104 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 24, 2007
|Last Updated:
|September 27, 2007
Keywords provided by University of Erlangen-Nürnberg Medical School:
traumatic brain injury
Subarachnoid Hemorrhage
Additional relevant MeSH terms:
Wounds and Injuries
Brain Injuries
Subarachnoid Hemorrhage
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Craniocerebral Trauma
Trauma, Nervous System
Pathologic Processes
Intracranial Hemorrhages
Cerebrovascular Disorders
Vascular Diseases
Cardiovascular Diseases
Pituitary Diseases
Hypothalamic Diseases
Endocrine System Diseases
ClinicalTrials.gov processed this record on September 21, 2017


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text: Seller: debenhamantiques (1,015) 100% , Location: Stowmarket, Ships to: Europe, US, CA, Item: 131041692415 Condition: Please ask for a condition report. We do our up most to send everything out in as good condition as we can but please remember you are buying antiques and you always get some wear and tare with age that is what they are antique., Product Type: Bookcases, Original/Reproduction: Original, Style: EMPIRE, Age: 1800-1899, Material: Mahogany, Details: 50 CONTINUOUS YEARS OF DEALING, OUR REPUTATION COUNTS CONTACTIAN COLLINS email email@example.com Mobile : 07715 006 41519TH CENTURY FRENCH EMPIRE MAHOGANY BOOKCASE CABINETFREE DELIVERY TO ANYWHERE IN THE UK ( MAINLAND ONLY ) AT THE BUY IT NOW PRICE ONLYIF NOT BROUGHT AT THE BUY IT NOW PRICE PLEASE CONTACT ME FOR A QUOTE FOR TRANSPORT.WE CAN SHIP ANYWHERE IN THE WORLD WITH DHL OR WILLIAMS AND HILL FINE ART AND ANTIQUE SHIPPERS OF LONDON AND NEW YORK 19TH CENTURY FRENCH EMPIRE MAHOGANY BOOKCASE CABINETHERE WE HAVE A TALL BOOKCASE CABINET. TOP SECTION COMPRISES OF 5 SHELVES, MOVING TO A SINGLE DRAWER AND FINISHING WITH A DOUBLE DOOR CUPBOARD WITH 1 DRAWER.ADORNED WITH ORMULU MOUNTS.HEIGHT: 92 1/4"WIDTH: 42 1/4"DEPTH: 21" EA034-129 Click to view supersize image Click to view supersize image Click to view supersize image Click to view supersize image Click to view supersize image Click to view supersize image All major credit and debit cards Cheques ( cheques must be cleared before item is either collected or delivered ) All payments must be cleared funds in our account before collection or delivery. Delivery can be arranged anywhere in the world but this is at a extra cost to the winning bidder. We do find our quotes very resemble and we do work hard to get the best price for our customers. For delivery's in the UK we can do in house but a small cost to the customer. Starting delivery cost in the UK £85 up to 100 miles from our location this is for larger items only. smaller items can be posted using TNT postage services. Remember, your bid is a legal and binding contract, and we treat it as such. To help avoid legal action, please don't bid if you are not prepared to pay. By bidding you acknowledge you have read and understand all of our terms, conditions, shipping and other clauses in our auctions. Occasionally we must end an auction early due to an error in the listing, discovery of damage to an item, or sale of the item in our local store. We appreciate your understanding in these circumstances. We do our best to have a smooth transaction. To help us, you MUST make any special requests at the same time you make your payment! Otherwise, we cannot guarantee your request will be fulfilled because it might not get to your order prior to packaging or shipment. Remember most antiques will show some wear as they are old and have been used. In some instances there might be prior repairs that we are not aware of. No refunds will be made due to a repair allegedly de-valuing the item. We are highly experienced with antiques, but are not professional appraisers. We make no guarantees on the age or appraised value of these antiques. If we state an age in our description, it is correct to the best of our knowledge. In the unlikely event that an item is damaged in shipping we will repair or replace the item with a similar item, at our discretion, and of course try to make you as happy as possible. We are professional and have been in the antique business for over 30 years. We are committed to EXCELLENCE and our staff are trained to treat our customer's right! Measurements are deemed reliable, but not guaranteed. On rare occasions, we do make typographical or clerical errors. If you believe there is a factual discrepancy, please notify us prior to the end of the auction for clarification. Debenham Antiques has been in existence for nearly 50 years and in that time we have grown to what it is today. Our Showroom is 2500 Sq ft on one level with plenty of car parking space. We do work closely with our Clients and dealers either at home or overseas We are open six days a week but advise customers to phone and check before setting out on a journey. Monday 9.00am - 6.00pm Tuesday 9.00am - 6.00pm Wednesday 9.00am - 6.00pm Thursday 9.00am - 6.00pm Friday 9.00am - 6.00pm Saturday 9.00am - 6.00pm Sunday By Appointment All other hours by Appointment Most Cards Accepted by phone. Debenham Antiques Ltd Debenham, Suffolk , IP14 6QS email@example.com If you have any questions regarding this item please email me at email@example.com I do have spam softwear so when you send me a email you will get a email back asking you to confirm your email address don't be alarmed. If you would like to know more about my company please email or look for Debenham Antiques Ltd on google. DEBENHAMANTIQUESLTD Store


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Netflix, you were right. I liked Downton Abbey. And thanks, Amazon I do want to read Michael Lewis' new book. I still can't figure out how Google knows I have a new dog.
Even if at times it feels a bit eerie, such 'consumer-of-one' marketing is a convenience many of us have come to appreciate. And it's an approach now embraced by most major retailers.
The exception? You've guessed it: the ever-old fashioned electric utility.
Added by Elisa Wood on May 10, 2014 at 1:19am — 3 Comments
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Keep kids learning
Worried your kid forgets everything they've learnt when not at school? Here's how to keep their brain sharp. more
Playing and interacting with our children has a range of well-known benefits: it builds relationships, strengthens bonds, fosters learning and, best of all, children love it. But that doesn't mean we need to be playing with our children all of the time. Nor does it mean we need to provide all of their entertainment for them when together time is over, lest we feel guilty for leaving them bored. On the contrary, leaving children to figure out what to do with themselves is actually good for them.
Creativity requires ingenuity, the ability to break through boredom and to make-do. Here are some of the ways you can help creativity flourish in your child.
"While kids need a few things in their room that they can play with – particularly things such as building blocks, coloruing in pencils, books, dolls, cars, etc. – I have to say the more toys you give them, the less likely they are to be creative in their play," says child psychologist Judith Locke.
"Many parents will recognise that some of the things kids play with the most are odd things like a tape measure or a pair of tongs."
Locke says it's important to keep a check on their toys – they really shouldn't have so many that they don't appreciate what they have – or play with what they do have. "When kids get everything they want, this can lead to them expecting everything they want, which can lead to future dissatisfactions, even credit card debt."
Leaving children to play independently teaches kids to be creative, learn to solve problems and be self-reliant as this mum has discovered.
Mum of three, Isabel De Bono says although she organises structured play activities that she does together with the kids, she feels children learn more from independent play and exploration. "I allow my children to play on their own a lot. I put out various activities and they choose what they want to play," says De Bono. "This not only teaches them that they don't have to rely on me but it gives them the opportunity to do what they want to do, not just do an activity I choose for them."
For some parents, the concept of independent play can be confusing. Locke suggest the following ideas:
Of course, when it comes to simply leaving children to their own devices, many parents struggle with guilt, feeling as though it's their job to entertain their children at all times. It's important to remember that you're actually doing your kids a favour and teaching them skills they'll use for life. We're parents, not playmates.
"I believe children are children and 'just play' is an important part of that learning," says De Bono. "If children can play independently it frees up time to do things I have to do. This enables me to feel guilt-free if I choose to sit around some days and just watch them play or do various activities with them if I wanted to.
"If I have something to do I know that they will be OK to play for a while without me. I have always tried to give my children as many experiences as I can as they grow up," De Bono says. "Children are like sponges when they are young. They crave information. But they also enjoy exploring and finding out things on their own."
This article was written for Kidspot by Nicole Madigan with additional information from Judith Locke.


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It looks like the Pali Text Society has made available the entire English translation of the Sutta Pitaka in digital format for free!
The following works originally published by the Pali Text Society are being offered under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) licence. The publisher retains commercial rights. Permission has been granted to the public to reproduce, reformat, transmit and distribute these works for gratis, non-commercial use without further need to contact the publisher.
see: http://obo.genaud.net/dhammatalk/dhamma ... ts.new.htm
This is absolutely fantastic. I am totally flabbergasted and most thankful to the Pali Text Society.


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Saturday, April 30, 4 pm ET/3 pm CT/1 pm PT
KANSAS CITY (1-1-1, 4 pts) vs. D.C. UNITED (1-2-1, 4 pts)
Key Players Out: Kansas City - MF John Minagawa-Webster (R ankle sprain); MF Doug Lascody (R ankle sprain); D.C. United - MF Dema Kovalenko (Jones fracture); DF Bryan Namoff (rib avulsion fracture);
Referee: Brian Hall.
Saturday, April 30, 7:30 ...
Manfred Schellscheidt, who has collected pro, amateur and youth national championships and now heads U.S. SoccerÆs U-14 boys development program, lets the game do the teaching.
By Mike Woitalla Soccer America Magazine
It was 34 years ago when Manfred ''Manny'' Schellscheidt became the first coach granted an ''A'' license by the U.S. ...
April 27 Chelsea (Eng.) 0 Liverpool (Eng.) 0.
April 27 in Chicago
Chicago 0 New England 3. Goals: Dempsey (Joseph, Twellman) 32, Noonan (Riley, Dempsey) 43, Twellman 95+.
Chicago - Thornton, Brown (Herron, 78), Curtin, Caballero, Gray, Armas, Marsch (Rolfe, 69), Guerrero, Thiago, Jaqua (Barrett, 72), Mapp.
New England - Reis, Heaps, Parkhurst, John, Riley (Vercollone, 86), Dempsey, Dorman, Joseph, Leonard, Twellman, Noonan.
Yellow Cards: Chicago - Caballero ...
By Ridge Mahoney, Senior Editor Soccer America Magazine 'GAME' RECAP: By now, word has spread that filmmakers Angelo Pizzo and David Anspaugh took some factual liberties with the story of the U.S. team that stunned England, 1-0, in the 1950 World Cup. The England game was the second game played by the U.S. at the tournament, not ...
Wednesday, April 26, 7 pm ET/6 pm CT/4 pm PT
CHICAGO (2-1-1, 7 pts) vs. NEW ENGLAND (2-0-1, 7 pts)
TV: Fox Soccer Channel, Fox Sports Net New England.
Direct Kick: DirecTV - 791; Dish Net - 464.
Key Players Out: Chicago - MD Craig Capano (L torn ACL); New England - GK Kyle Singer (R shoulder sprain).
Referee: Hilario Grajeda.
Bryan Hill Harrisburg. Eight saves, two shutouts in 0-0 tie, 1-0 win
Paul Caffrey Long Island. Goal, assist in 4-1 win over Northern Virginia
Derek Smith Cincinnati. Solid play in 0-0 tie versus Harrisburg
Kyle Fletcher Western Mass. Long goal in 3-1 loss at Wilmington
Mo Oduor Harrisburg. Game-winner in 1-0 win over Pittsburgh
Dustin Swinehart Charlotte. Hat-trick, assist in win over Northern Virginia
Jack ...
Ronnie Pascale Richmond. Nine saves in wins over Atlanta, Virginia Beach
Russell Hutchison Virginia Beach. Game-winner in 1-0 win over Richmond
Rumba Munthali Toronto. Solid play in 0-0 tie at Vancouver
Kevin Knight Richmond. Assist in 3-1 win over Atlanta
Darren Caskey Virginia Beach. Goal, assist in weekend split against Richmond
Alfredo Valente Vancouver. Solid play in 0-0 tie versus Toronto
Chris Goos Charleston. Lone goal ...
Chicago Fire rookie Chad Barrett set up goals by Benny Feilhaber, Will John and Danny Szetela before Tim Ward added a fourth goal as the U.S. under-20 national team beat the Seattle Sounders of the USL First Division, 4-1, Monday night in Seattle.
The Under-20s will play their next preparation match in three weeks when they face Canada on May 18 ...
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I am deeply saddened by the passing of Congressman Bill Young this evening. On behalf of the three million men and women of the Department of Defense, I want to express our heartfelt condolences to Beverly and the Young family. I have known and respected Bill Young for more than four decades. He dedicated his life to serving our country -- beginning with nearly a decade in the Army National Guard and culminating in more than 40 years in the U.S. House of Representatives. He will be remembered as a passionate advocate for the welfare of America's service members and military veterans. Though his loss will be felt by many, his legacy and commitment to a strong national defense will always inspire us.
Source: http://www.defense.gov/releases/release.aspx?releaseid=16324


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At its core, Girls feels like a deliberate, dissective examination of a group of people who stubbornly refuse to grow up and are lucky enough to be able to pull it off. The main thing Dunham's characters share is the idea that just because they exist, somebody else should give them stuff. In and of itself, depicting that isn't at all a bad thing. Girls is an interesting project, it's well executed, and it can be really, really funny. Look, I like Girls, and I'm excited about the second season.
But Dunham's stupid little YouTube ad for the president might have ruined it all for me. That's because she sounds like she's channeling her character, Invasion of the Body Snatchers–style. They share the same baffling, naïvely egomaniacal understanding of justice — they both seem to think that because they exist, the universe needs to make sure that all the sex they choose to have is consequence-free.
You can almost argue that Lena Dunham sees President Obama as the perfect surrogate for everything missing in her characters' lives: He's their gentle lover, supportive parent, and empathetic friend. He's special. He won't let them down. He's Prince Charming. And that kind of defeats the purpose of feminism.


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Home performance is to Apple as standard building practices are to the generic PC industry. We, the adherents to the whole house, high quality approach to assessing and managing the performance of homes, are Apple. The standard, old school, business-as-usual approach to building and renovating homes is the rest of the computer industry.
This idea got seeded after reading James Stewart's article,…Continue
Added by Peter Troast on October 11, 2011 at 2:00pm — 2 Comments
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What are some of the risk factors for postpartum cows to be anovular (non-cycling) for a prolonged length of time? Researchers at the University of Guelph set out to find some answers using data from 2,178 Holstein cows in six commercial herds. The results were published in the April issue of the Journal of Dairy Science.
The researchers tracked:
- Periparturient disease incidence.
- Calving score.
- Body condition.
Whether a cow ovulated early or had prolonged anovulation was associated with:
- Negative energy balance.
- Uterine inflammation during the peripartum period.
- Milk production level.
- Parity.
- Season.
Cows that ovulated by 21 days in milk were associated with a shorter time to pregnancy. Conversely, and not surprisingly, prolonged anovulation was detrimental to subsequent reproductive performance and increased likelihood of culling.
The researchers cautioned that the effects of prolonged anovulation on reproduction were worse in cows of third parity or greater, recommending that producers apply targeted mitigation strategies to those groups of cows.