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3rd Annual St. Louis Teen Talent Competition Begins Today
The 3rd Annual St. Louis Teen Talent Competition gets underway today, February 9 and tomorrow, February 10, when 161 acts take the stage in the preliminary round of the competition (a complete list of students/schools can be found here).
"We are excited to see so many more students register for the Teen Talent Competition this year! We have an even greater range of talent including a ventriloquist, comedian, a diabolist, and several bands. We are pleased to have added more prizes and scholarship awards for our participating students," says Mary Strauss, President of Fox Performing Arts Charitable Foundation Board of Directors, "We hope all St. Louisans will come out and support our talented teens for the final competition on Friday, April 12, 2013 at the Fabulous Fox. It's a great opportunity for the whole family to see great talent on the Fox stage FREE OF CHARGE."
The Fox Performing Arts Charitable Foundation (FPACF) first produced this competition in 2011 to showcase the St. Louis region's most talented teens in the performing arts; singers, dancers, actors, musicians, comedians and circus arts performers compete as soloists or in groups of as many as six.
The number of entries increased over 30% this year and include an even wider variety of acts. The competition process, filmed by Miano.tv, will be available on our own SchoolTube channel graciously donated by SchoolTube.com. Highlights of last year's event and the winning performances from the 2011 and 2012 Showcase can be seen on our SchoolTube and YouTube pages.
Judges for the preliminary round will again include an impressive cross section of professionals from the St. Louis performing arts community. A complete list of preliminary judges is available on the FPACF website.
The two days of preliminary competition at three locations (Lindenwood-Belleville, St. Louis Community College-Forest Park, UMSL) will narrow the field to approximately 36 acts. These acts will compete in the Semi-final round of competition on March 2nd where 10-12 acts will be chosen to compete in the finals at The Fox on Friday, April 12, 2013. A total of $15,000 in scholarships will go to the top three finalists. Additional scholarships and prizes include: $1,000 from UMSL to first place; scholarships from Lindenwood and Missouri Baptist for all participants; scholarships from Webster and SEMO to all finalists; and an additional $7,5000 in special prizes will be awarded to contestants. A full list of special awards and prizes can be found on the FPACF website. Both The Muny and STAGES will offer one student the opportunity to participate in a 2013 production. FPACF also provides the finalists with additional opportunities to perform at area events throughout the year. Last year finalists showcased their talents at the Shakespeare Festival, Webster's Art & Air Festival, The Muny, National Dance Week Celebration and Dancing in the Street.
Complete guidelines and information about the 3rd Annual 2013 St. Louis Teen Talent Competition can be found on the Foundation's website and on the FPACF Facebook page. Important dates for this year's showcase are:
Preliminary Rounds of Competition: February 9-10, 2013
Semi-final Round of Competition: March 2, 2013
Final Competition on stage at The Fox: April 12, 2013 (FREE)
The amazing community response to this free final competition at the Fox has grown over the past two years with "sold out" crowds. We are pleased to announce that The Nine Network will once again broadcast an hour-long program on the 2013 competition with support from St. Louis Community College. Over the past two years more than 120,000 viewers tuned in to The Nine Network's hour-long program.


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subset: commoncrawl


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June 11, 2014
A new study found that people in the first year of being diagnosed with lupus were 7.4 times as likely to have a stroke than people without lupus. People with lupus under 45 were six times at greater risk for stroke than their peers without lupus. Results were presented at the Canadian Rheumatology Association's 2014 annual meeting.
Source: Pain Medicine News


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Back to Main
Faculty Detail
Campus Address
BBRB 258B Zip 2170
Other websites
Faculty Appointment(s)
Appointment Type
Professor Emeritus
Comp Arthritis, MSK, Bone & Autoimmunity Ctr
Comp Arthritis, MSK, Bone & Autoimmunity Ctr
Professor Emeritus
Comprehensive Cancer Center
Comprehensive Cancer Center
Professor Emeritus
General Clinical Research Center
Nephrology Research & Training Center
Professor Emeritus
Graduate Biomedical Sciences Affiliations
Cellular and Molecular Biology Program
Medical Scientist Training Program
Biographical Sketch
Suzanne M. Michalek is Professor of the Department of Microbiology. Following her initial training in genetics (B.S., 1967; M.S., 1968), she initiated studies in immunology at the University of Chicago with emphasis on the mucosal immune system. Her studies at UAB (Ph.D., 1976) on the induction of salivary IgA antibody responses protective against Streptococcus mutans-induced dental caries provided evidence for the existence of a common mucosal immune system and for the development of a human oral vaccine against dental caries. Following postdoctoral studies at NIH on the effects of bacterial LPS on the host's immune system, she joined the Mucosal Immunology Group at UAB (1979).
Society Memberships
Organization Name
Position Held
Org Link
American Academy of Microbiology
American Society for Microbiology
International and American Association for Dental Research
Society for Leukocyte Biology
Society for Mucosal Immunology
The American Association of Immunologists
The International Endotoxin Society
Research/Clinical Interest
Immunological mechanisms involved in host/microbial interactions, and development of mucosal vaccines against infectious agents
My research program centers around two major themes: 1) understanding immunological mechanisms involved in host/microbial interactions, with emphasis on host responses to the pathogens Porphyromonas gingivalis and Francisella tularensis, and 2) the development of mucosal vaccines against infectious diseases. P. gingivalis is involved in the development of periodontal disease, an inflammatory process that has also been linked to systemic disorders such as cardiovascular disease. Our studies with P. gingivalis focus on the cell signaling molecules and transcription factors involved in the host response this pathogen. F. tularensis is the cause of tularemia. Due to its ability to infect via multiple routes, its ease of dissemination, and its high infectivity, morbidity and rate of mortality, F. tularensis is considered a bioterrorism agent. The nature of the inflammatory response induced by Francisella infection is a critical determining factor of the outcome of the infectious process. Our studies are directed to delineate the signaling pathways and potential target molecules that could be implicated in the inflammatory process. Through a better understanding of the cellular mechanisms involved in the host immune response to these pathogens, we hope to identify target molecules for the development of protective immunotherapeutic approaches. Since greater than 95% of all infectious disease involve the colonization or penetration of our mucosal surfaces, our mucosal immune system serves as our first line of defense against pathogens. Therefore, we have devoted considerable effort to understanding the mucosal immune system and in developing mucosal vaccines against microbial pathogens. Current in vivo studies in adults and children are testing the effectiveness of our mucosal vaccine consisting of recombinant microbial polypeptides from Streptococcus mutans (the principle etiologic agent of tooth decay) in inducing mucosal as well as systemic immune responses that protect against dental caries. We have also developed a mucosal vaccine that confers greater than 80% protection against respiratory infection by the biologic threat agent F. tularenesis. These studies are being done in a murine model. Ongoing studies are designed to test the effectiveness of our vaccine in protecting against highly virulent forms of this pathogen and in additional model systems. We also plan on determining the effectiveness of our vaccine in the elderly, since it is well know that age does affect our immune system, making us more susceptible to diseases. It is possible that our vaccine may need to be modified by including additional antigens/adjuvants to make it even more effective in inducing protective responses in the population at large. Our studies should help in the development of means to treat/prevent infectious diseases via therapeutic approaches and/or mucosal vaccines. Since microbial pathogens, e.g., P. gingivalis, can alter the outcome of systemic diseases, such as kidney disease, cancer or depression, we are also investigating the cellular mechanisms involved in these processes in an effort to define therapeutic approaches that would help in the treatment of systemic diseases/disorders.
Selected Publications
Yang, D., Chen, Q., Su, S.B., Zhang, P., Kurosaka, K., Caspi, R.R., Michalek, S.M., Rosenberg, H.F., Zhang, N., and Oppenheim, J.J. 2008. Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J. Exp. Med. 205: 79-90.
Seo, H., Michalek, S.M., and Nahm, M.H. 2008. Lipoteichoic acid is important in innate immune responses to gram-positive bacteria. Infect. Immun. 76: 206-213.
Cole, L.E., Shirey, K.A., Barry, E., Santiago, A., Rallabhandi, P., Elkins, K.L., Puche, A., Michalek, S.M., and Vogel, S.N. 2007. TLR2-mediated signaling requirements for Francisella tularensis LVS infection of murine macrophages. Infect. Immun. 75: 4127-4137.
Zhang, P., Lewis, J.P., Michalek, S.M., and Katz, J. 2007. Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A. Vaccine 25: 6201-6210.
Banas, J.A., Miller, J.D., Fuschino, M.E., Hazlett, K.R.O., Toyofuku, W., Porter, K.A., Reutzel, S.B., Florczyk, M.A., Mc Donough, K.A., and Michalek, S.M. 2007. Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutation. Appl. Environ. Microbiol. 73: 357-361.
Childers, N.K., Li, F., Dasanayake, A.P., Li, Y., Kirk, K., Michalek, S.M. 2006. Immune response in humans to a nasal boost with Streptococcus mutans antigens. Oral Microbiol. Immunol. 21:309-313.
Salam, M.A., Katz, J., Zhang, P., Hajishengallis, G., and Michalek, S.M. 2006. Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system. Vaccine 24:5003-15.
Cole, L.E., Elkins, K.L., Michalek, S.M., Qureshi, N., Eaton, L.J., Rallabhandi, P., Cuesta, N., and Vogel, S.N. 2006. Immunologic consequences of Francisella tularensis live vaccine strain infection: role of the innate immune response in infection and immunity. J. Immunol. 176:6888-6899.
Katz, J., Zhang, P., Martin, M., Vogel, S.N., and Michalek, S.M. 2006. Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS. Infect. Immun. 74:2809-2816.
Han, S.H., Kim, J.H., Martin, M., Chung, G-H., Michalek, S.M., and Nahm, M.H. 2005. Lipoteichoic acid-induced nitric oxide production depends on the activation of PAF receptor and Jak2. J. Immunol.176:573-579.
Zhang, P., Yang, Q-B., Balkovetz, D., Lewis, J.P., Clements, J.D., Michalek, S.M., and Katz, J. 2005. Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recominant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalis. Vaccine 23:4734-4744.
Pino, O., Martin, M., and Michalek, S.M. 2005. Cellular mechanisms of the adjuvant activity of the flagellin component FljB of Salmonella typhimurium to potentiate mucosal and systemic responses. Infect. Immun. 73:6763-6770.
Martin, M., Rehani, K., Jope, R.S., Michalek, S.M. 2005. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase. Nature Immunol. 6:777-784.
Zhang, P., Martin, M., Michalek, S.M, and Katz, J. 2005. Role of mitogen-activated protein kinases and NF-ƒÛB in the regulation of pro- and anti-inflammatory cytokines by Porphyromonas gingivalis hemagglutinin B. Infect. Immun. 73:3990-3998.
Menendez, A., Li, F., Michalek, S.M., Kirk, K., Makhija, S.K., Childers, N.K., 2004. Comparative analysis of the antibacterial effects of combined mouthrinses on Streptococcus mutans. Oral Microbiol. Immunol. 20:31-34.
Garcia, C.A., Martin, M., and Michalek, S.M. 2004. Role of B7 costimulatory molecules in mediating systemic and mucosal antibody responses to an attenuated Salmonella enterica serovar Typhimurium and its cloned antigen. Infect. Immun. 72:5824-5831.
Russell, M.W., Childers, N.K., Michalek, S.M., Smith, D.J., Taubman, M.A.. 2004. A caries vaccine? The state of the science of immunization against dental caries. Caries Res. 38:230-235.
Zhang, P., Martin, M., Yang, Q-B., Michalek, S.M., and Katz, J. 2004. Role of B7 costimulatory molecules in immune responses and T-helper cell differentiation to recombinant HagB from Prophyromonas gingivalis. Infect. Immun. 72:637-644.
Han, S.H., Kim, J.H., Martin, M., Michalek, S.M., and Nahm, M.H. 2003. Pneumococcal lipoteichoic acid (LTA) is not as potent as staphylococcal LTA in stimulating Toll-like receptor 2. Infect. Immun. 71:5541-5548.
Zhang, P., Yang, Q-B., Marciani, D.J., Martin, M., Clements, J.D., Michalek, S.M., and Katz, J. 2003. Effectiveness of the quillaja saponin semi-synthetic analog GPI-0100 in potentiating mucosal and systemic responses to recombinant HagB from Porphyromonas gingivalis. Vaccine 21:4459-4471.
Martin, M., Schifferle, R.E., Cuesta, N., Vogel, S.N., Katz, J., and Michalek, S.M. 2003. Role of the P13 kinases-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J. Immunol. 171:717-725.
mucosal vaccines, inflammation, TLRs, T cell, cytokines, signaling pathways
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Kelly Osbourne: 'My mom won't let me get married'
By Michelle Lanz
Kelly Osbourne's lookin' damn good lately, after kicking her prescription drug habit and dancing off some extra pounds on "Dancing With the Stars." She sat down for a chat this week with Barbara Walters (and special guest Dr. Phil) on the "Here's Barbara" SIRIUS XM Radio show and got candid about her drug use, her engagement and her mom's breast implants.
On her engagement and no rush to get married:
"I think that when I was first asked by Luke, I said yes just to say yes, and that's the truth. Because, I remember sitting there and having someone looking at me and thinking, 'God, he must have so much balls just to ask me to marry him.' And to tell him no I felt would ruin our relationship. So right now I'll just say yes. And then after the first year, I started to realize ... maybe I really do want to marry. My mom won't let me get married, but ... I don't want to be married until I'm 30."
RELATED VIDEO: Kelly on Sharon removing implants
On how she feels about infidelity in relationships:
"I think that…being brought up in an industry where cheating is rampant, I grew up on the road. I grew up learning from men what relationships are all about and ... I guess you can say I've been tainted because of seeing it so young. There is no messing around when it comes to that area for me. And I do think that you're right when you say that there is a genetic predisposition for somebody to be a cheater or not. And because of growing up with so many men, I think that it was very easy for me to see at a very young age, what kind of men were what kind of men."
On her struggle with drugs:
"I think that that was probably one of the hardest things that I've ever have to get over. And it is something that you take with you for the rest of your life. I was talking about this with my brother yesterday. People are under the assumption that you go to rehab, you get better, you learn the skills of life. But it's never like that. It is a constant battle every single day. It becomes more of a battle that you enjoy taking part in because you have control over your life all of a sudden and your life isn't miserable. I never say never because you never know what life holds, and you never know what's going to happen, but I will do anything I have to never go back there again."
RELATED: See which celebs are showing off their beach bods
On which drugs she abused:
"I liked prescription drugs. Like prescription painkillers: Vicodin and OxyContin, and stuff like that."
On whether being famous had something to do with her drug abuse:
"In retrospect, fame and money means nothing if you walk around hating yourself in your life every single day. I told myself I was never going to do drugs, because I never wanted to be like my father. But then I moved to L.A., and I was so foreign, and I was so uncomfortable, and someone said to me - take this. And it came from a doctor's bottle, and I figured, nothing from a doctor is going to kill me, because doctors are there to help people. And then I went down the same path as well. I honestly think that whether I was famous or whether I was not, whether I lived on a farm in England or in Beverly Hills, I still would have been a drug addict.
RELATED: See which celebs look like they hate the sun
On "Dancing with the Stars":
"What I got from that show, I … don't even have the words to describe it. Because I went into it thinking, 'I'll lose a bit of weight and they'll give me a sparkly dress. This'll be nice. Just for a little bit. But I won't last more than a week.' And each week that I stayed in longer, I learned something new about myself. And I discovered this whole new sense of dedication and self-worth and confidence I got from it, which was crazy because it's such a vulnerable experience to express yourself with your body when you're so used to be doing it with your mouth…and…to…be incredibly girly, which was something I had never done before. It was such an experience. I would do it again if I could. I've lost about forty pounds now. Which I was really, really, really happy about.
On her mom Sharon Osbourne's breast implants:
"I think it's a very unattractive thing for a woman to have massive, massive boobs. I think if they're going to be big, they have to be natural. Or big, but not too big, if you know what I mean … When she came back from having whatever plastic surgery she had done, we all looked at her like what made you think that was a good idea to do, why did you do that? We kind of giggled it off. She goes 'Oh, I don't know.' And it became kind of like an inside joke like, 'Oh, Mom and her big boobs.'"


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Safety and Efficacy Study of BCD-020 in Therapy of Non-Hodgkin's Lymphoma
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This international multi-center, randomized, controlled, open-label study will investigate the pharmacokinetics, pharmacodynamics, efficacy and safety of BCD-020 (NN: rituximab, CJSC Biocad) versus MabThera (INN: rituximab, F. Hoffmann La Roche, Ltd.) both administered as a monotherapy of patients with indolent non-Hodgkin's lymphoma.
Patients will be randomized to receive 375 mg/m² BCD-020 as intravenous infusion once a week for 4 weeks or MabThera at the same regimen.
|Follicular Non-Hodgkin's Lymphoma Nodal Marginal Zone Lymphoma Splenic Marginal Zone Lymphoma
|Biological: rituximab
|Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Multicenter Open-label Randomized Study of BCD-020 (Rituximab, CJSC BIOCAD, Russia) Efficacy and Safety in Comparison With MabThera (F. Hoffmann-La Roche Ltd., Switzerland) in Monotherapy of CD20-positive Indolent Non-Hodgkin's Lymphoma
- CD20-positive cells count [ Time Frame: day 50 ]Comparison of peripheral blood B-cell depletion and repletion after BCD-020 and MabThera intravenous administration
- Overall response rate [ Time Frame: day 50 (cycle 4) ]Estimation of the overall response rate in each treatment arm at the end of treatment
- Cmax [ Time Frame: day 22 ]Estimation of of rituximab serum concentrations after administration of BCD-020 to that obtained after administration of MabThera
- Complete response rate [ Time Frame: day 50 ]Assessment of complete response rates of BCD-020 and MabThera given as a monotherapy at the end/completion of the treatment
- Frequency of AEs/sAEs grade 3-4 (CTCAE v.4.03) [ Time Frame: day 50 ]Evaluation of the safety profiles of BCD-020 and MabThera
- Levels of binding and neutralizing antibodies to rituximab [ Time Frame: day 50 ]Immunogenicity assessment of BCD-020 and MabThera
- AUC(0-1176), AUC(0-inf) [ Time Frame: day 50 ]Estimation of rituximab serum concentrations after administration of BCD-020 to that obtained after administration of MabThera
|Estimated Enrollment:
|Study Start Date:
|September 2011
|Estimated Study Completion Date:
|December 2016
|Estimated Primary Completion Date:
|October 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: MabThera
Patients will receive originator rituximab at a dose of 375 mg/m2 intravenously once a week for four weeks (on days 1-8-15 and 22)
Biological: rituximab
Patients will receive rituximab at a dose of 375 mg/m2 intravenously once a week for 4 weeks (on day 1,8,15,22)
Other Name: Biological: BCD-020, MabThera
Experimental: BCD-020
Patients will receive proposed rituximab biosimilar at a dose of 375 mg/m2 intravenously once a week for four weeks (on days 1-8-15 and 22)
Biological: rituximab
Patients will receive rituximab at a dose of 375 mg/m2 intravenously once a week for 4 weeks (on day 1,8,15,22)
Other Name: Biological: BCD-020, MabThera
|Ages Eligible for Study:
|18 Years to 95 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Having signed a written informed consent;
- Patients' age is 18 years or more;
- Diagnosis of CD20-positive indolent non-Hodgkin lymphoma of following morphological types:Follicular non-Hodgkin lymphoma stage II-IV according to Ann Arbor, grade I-II;Nodal marginal zone lymphoma stage II-IV according to Ann Arbor; Splenic marginal zone lymphoma.
- Life expectancy of not less than 3 months after the enrollment in the study;
- Morphological and immunohistochemical examination of the tumor (both lymph node biopsy and bone marrow biopsy) - within 3 months before the enrollment in the study ;
- Performance status ≤2 on the ECOG scale;
- Hemoglobin > 80 g/l; leukocyte count ≥ 3.0×109/l but less than 25×109/l, absolute neutrophil count ≥1.5×109/l, platelet count ≥100×109/l;
- Presence of at least one measurable lesion;
- Patient's ability in the investigator's opinion to comply with the protocol procedures;
- Willingness of patients with preserved reproductive function to use reliable contraception methods (at least two contraception methods in women, e.g., spermicide and condom).
Exclusion Criteria:
- Bulky disease - size of any single lesion more than 10 cm in the greatest diameter;
- Secondary transformation to high-grade lymphoma;
- Other types of non-Hodgkin lymphomas apart from follicular non-Hodgkin stage II-IV lymphoma according to Ann Arbor, grade 1,2; nodal marginal zone lymphoma stage II-IV according to Ann Arbor; splenic marginal zone lymphoma.
- Patients regularly taking corticosteroids during 1 month preceding the enrollment in the study;
- Occurrence of other (aside from NHL) diseases that can distort the assessment of the main disease symptoms expression; mask, enhance, modify the main disease symptoms or induce clinical and laboratory-instrumental symptoms similar to the non-Hodgkin lymphomas; Severe resistant hypertension; Decompensated forms of heart (NYHA class ХСН III, IV), liver and kidney disorders (creatinine level >133 µmol/l, AST, ALT, and bilirubin level 3 times exceeding the norm) except for the cases where the symptom is caused by lymphoma; Decompensated respiratory failure; Tumor infiltration of the lungs; Decompensated diabetes mellitus; Active autoimmune diseases; Ongoing infections requiring antimicrobial therapy.
- Usage of the drugs:
At any time prior to the enrollment into the study - interferon-based drugs or monoclonal antibodies for the treatment of NHL; Chemotherapy or radiotherapy was completed less than 21 day prior to the enrollment into the study; Vaccination within 1 week prior to the enrollment into the study;
- Presence of any psychiatric disorders including major depressive conditions and/or suicidal thoughts in anamnesis that in opinion of the investigator may put a patient at an excessive risk or influence the ability of patients to fulfill the study protocol;
- Myocardial infarction less than 1 month before the enrollment into the study;
- Severe CNS or PNS dysfunctions;
- Drug and alcohol addiction;
- Known HIV, HBV, HCV infection, syphilis;
- Known primary or secondary immunodeficiency;
- Primary CNS lymphoma or metastasis in the CNS;
- Known intolerance or allergy to mouse proteins or any components of the study drugs, and also to the premedication drugs;
- Pregnancy or lactation;
- Prior or concomitant malignances except for adequately treated basal cell carcinoma and in situ cervical cancer;
- Any restraints or impossibility to administer the study drug via an intravenous infusion;
- Major surgery within 1 week prior to the enrollment into the study;
- Simultaneous participation in any other clinical study or any preceding participation in other studies within 3 months prior to enrollment in this study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01701232
|Contact: Andrey Biryulin, MD
|(812) 3804933 ext 925
|Contact: Ekaterina Chernyaeva, MD
|(495) 9926628 ext 193
Show 73 Study Locations
|Study Director:
|Roman Ivanov, PhD,MD
|CJSC Biocad
Additional Information:
|Responsible Party:
|ClinicalTrials.gov Identifier:
|NCT01701232 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 3, 2012
|Last Updated:
|September 1, 2016
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
Keywords provided by Biocad:
lymphoma, non-Hodgkin's
Additional relevant MeSH terms:
Lymphoma, Non-Hodgkin
Lymphoma, B-Cell, Marginal Zone
Lymphoma, B-Cell
Lymphoma, Follicular
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Antineoplastic Agents
Immunologic Factors
Physiological Effects of Drugs
Antirheumatic Agents
ClinicalTrials.gov processed this record on September 21, 2017


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Fake BP Public Relations Twitter Account 10 Times More Popular Than the Real Thing
Without getting entrenched in the politics of what is undoubtedly one of the worst environmental disasters in US history, the fact that millions of gallons of crude oil is still spewing into the Gulf of Mexico more than a month after the oil rig explosion seems obscenely absurd. People tune in to their news source expecting to hear that the oil leak is at least contained but even now it appears the latest attempt by British Petroleum has failed to have an impact.
It is this absurdity that has given rise to a fake BP Public Relations Twitter account @BPGlobalPR that tweets satirical sentiments like: "Sadly we can no longer certify our oil as Dolphin Safe."
The account's owner remains anonymous (for now) though "he" recently had an interview with Brenna Ehrlich of Mashable. At the time of this writing @BPGlobalPR has collected over 84,000 followers since the first tweet on 5/19/10. That's more than 10 times the followers of BP's official Twitter account @BP_America which has about 8,100 followers and twice the tweets. It is really no surprise that more people would rather laugh than cry (so to speak). And as every good marketer knows, humor is a powerful memory hook.
Some people may feel that a parody of this kind is in bad taste but apparently BP doesn't think so given they have not asked Twitter to take down the account (see this AdAge article); a smart move on BP's part as they have enough to worry about without adding Twitter to the list.
The reason I write this post at all is that both BP and the fake BP make good use of the social network to address their respective audiences. For one it is about damage control and for the other it is about cause awareness (albeit in a droll sort of way not unlike John Stewart).
For the record, sales of the $25 BP Cares T-shirts being promoted on the fake BP Twitter feed actually goes toward the Gulf Restoration Network.


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THE man who will step into the shoes of Tim Prince, as chief executive of the RAF Charitable Trust Enterprises following RIAT 2014, says he feels privileged to be taking over such a unique organisation.
Andy Armstrong, whose appointment was announced this week, said he hoped to use his business experience to give something back to the RAF family.
He said: "I am genuinely excited and feel very privileged to be taking over the controls of such a unique organisation. I look forward to working alongside everyone at Douglas Bader House and hope to meet many of the extraordinary volunteers, whom I have heard so much about, as we get ready for this summer's Air Tattoo."
Andy, who is married with two children, will be working closely alongside Tim throughout the build-up to this summer's air show before formally taking over immediately after.
A marketing graduate, Andy has a strong track record in developing a wide range of consumer businesses, most recently managing the transition from physical to digital delivery of filmed entertainment as Sony Pictures Home Entertainment Northern Europe managing director.
He believes his interest in the Royal Air Force and his desire to support it was inherited from his father, who was the ATC Corps Chaplain for more than a decade.
"My enthusiasm definitely came from him," said Andy. "I remember being taken to an Air Tattoo when I was very young, to see one of the first displays of the Harrier. Watching an aircraft stop in mid-air, hover and then fly backwards for the first time was something I, and thousands of others that day, will never forget."
On leaving school, Andy was awarded a Cadet Flying Scholarship, which enabled him to obtain his Private Pilot's Licence and he continued flying with the University Air Squadron while studying at Strathclyde University.
Andy said: "Having personally benefited from the support of the RAF family, I think joining the RAFCTE and RIAT team is a fabulous opportunity to use all my experience to 'give something back'."
Tim said he was pleased to be handing over the reins to someone who not only valued what had been achieved in the past but who had the experience to take the organisation forward.
He said: "I know Andy has been attracted by the determined yet caring ethos of our highly capable and enthusiastic team and fully understands that aircraft comprise the core element of the Air Tattoo. "I am so pleased that I will be handing it all over to someone who values all that we have done in the past and who is looking forward to using his considerable experience to take the organisation forward."
This year, RIAT takes place on July 12 and 13. Earlybird tickets are available until May 31, saving £5 per ticket. Under 16s go free. For more information visit www.airtattoo.com.


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Permission to re-open a factory at Sands Farm Quarry, in Sandpit Road, Calne, has been given after a hard-fought battle against the application from residents at the new Steeple Chase development.
The factory, owned by Aggregate Industries UK Ltd, which makes concrete goods, was mothballed in 2009 because of the economic downturn and permission to run the factory was due to run out next month.
Plans to extend production until November 2022 dismayed residents at the new development, who bought their houses on the belief that the factory would not re-open, and expressed their concerns about traffic, noise and dust.
The application went before Wiltshire Council last September, but it was deferred to give planning officers time to mediate with Aggregate Industries over planning conditions.
Yesterday Wiltshire councillors approved new conditions, which mean lorries can only enter or leave the site between 6am and 6pm Monday to Friday and between 6am and 1pm on Saturday.
Lorries are also banned from entering and leaving the site on Sundays and on public holidays. All mechanical equipment on site will also have to be fitted with silencers.
There are now 500 people living on the Steeple Chase development at Sandpit Road and permission has been granted for the Hills Group to build 200 more houses between Oxford Road and Sandpit Lane.
Luisa Crook, from the Sandpit Road Residents' Association, said she hoped the conditions would alleviate people's concerns.
She said: "I would like to emphasise that we don't wish to stifle the business opportunities in Calne, however, we don't believe that this development can be at the expense of residents who have invested in the area. We feel that it's essential and not unreasonable to ask for regular noise monitoring."
Some councillors also tried to restrict factory operating hours, so that the factory could not operate 24 hours a day, but others said this would make the factory into an unviable business.
John Penny, representing Calne Aggregates, said: "As noted from the previous time this application was before you, there were a number of issued raised, which we believe have adequately dealt with.
"We believe that the statement we provided gives clear evidence that any potential environmental issues were considered back in 2008 and we believe this report remains relevant today. The ability to produce concrete products in the factory 24 hours a day is essential for the viability of the factory but we would be prepared to accept the restrictions on vehicle movements."


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Now that Congress's summer recess begins, Senate and House delegates are returning to their home states where they face many disgruntled farmers.
The recent session of Congress provided little relief for farmers, even with the Senate's passing of the farm bill. With the members of Congress back in their home states, it's time for farmers to let their delegates know what's important to them.
In an interview with the American Farm Bureau Federation, Dale Moore, American Farm Bureau public policy director, identifies three areas that need Congress's attention.
The first area is obviously the farm bill. While it passed in the Senate, it has yet to pass in the House. The current farm bill in effect expires at the end of September, making it a top priority for Congress. Moore says the farm bill is important "simply for the certainty it provides to producers." Producers can't plan ahead when they don't know what the farm bill will do.
The second area is the agricultural labor program, which couples with immigration reform. Agriculture requires a large labor force to satisfy its needs—whether harvest, planting or livestock care. Immigration reform would increase the agricultural workforce, providing farmers with the help that they need on their farms and in the fields.
Waterways improvement is the third most important issue to farmers. Rivers are used to transport 60 percent of corn supplies to their end-use locations. Unfortunately, many locks and dams that facilitate transportation haven't seen upgrades in decades.
Moore says that farmers need to voice their frustrations to their delegates if they want to see improvements: "I need you to go back to Washington and let folks know that we're tired of this, we're frustrated with the political process that seems to get tangled up on things, that impedes the progress…. We need to break the logjam and get it done."


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You can get the corresponding Class instance by using class literals e.g. int.class, float.class or boolean.class. It is also used to represent an instance of the array in Java. Every array with the same type and same dimension share the same instance of class Class.
Another use of java.lang.Class is while implementing equals() method to check whether two objects are of the same type or not.
java.lang.Class class in JavaEvery time JVM creates an object, it also creates a java.lang.Class object that describes the type of the object. All instances of the same class share the same Class object and you can obtain the Class object by calling the getClass() method of the object. By the way, this method is inherited from java.lang.Object class.
Suppose you create two instances of class called Person e.g.
Person A = new Person(); Person B = new Person(); if(A.getClass() == B.getClass()){ System.out.println("A and B are instances of same class"); }else{ System.out.println("A and B are instances of different class"); }
In this case, it will print "A and B are instances of the same class" because they are both instance of class Person.
We need forName() and newInstance() because many times it happens that we don't know the name of the class to instantiate while writing code , we may get it from config files, database,network or from any upstream Java or C++ application.
This is what we called the reflective way of creating an object which is one of the most powerful feature of Java and which makes way for many frameworks e.g. Spring ,Struts which uses Java reflection.


text: Putnam man gets life for killing girlfriend over interrupted sleep By Kate White September 28, 2012 Story Share WINFIELD, W.Va. -- Eric Brian Pauley told a Putnam County Circuit Court judge on Friday that he shot and killed his girlfriend last year because she interrupted his sleep."She woke me up. . . . It made me mad she woke me up like that in the middle of the night," Pauley, 50, of Winfield, told Circuit Judge Phillip Stowers before he pleaded guilty to first-degree murder.Stowers questioned Pauley's state of mind and asked if the couple had been arguing when he shot Debra Rosiek, 52, at their trailer in Winfield in September 2011."She come in, flipped the light on and started hollering," said Pauley, who noted that the couple normally got along and hadn't been arguing earlier that night.Pauley told the judge he grabbed his pistol that was beside the bed and underneath a stack of folded clean clothes and shot his girlfriend of four years.After waiving a pretrial sentence investigation, Stowers accepted the plea arrangement offered by prosecutors of life in prison with mercy. Pauley already has served 378 days and will be eligible for parole after 15 years.Pauley knocked on the door of the Putnam County Sheriff's Department at about 10 p.m. on Sept. 17, 2011, and told a deputy that he'd shot his girlfriend and believed she was dead. At the time, Detective Shawn Johnson said Pauley gave police a key to his home, and a deputy was then dispatched to Pauley's residence in the Winfield Mobile Home Village where Rosiek was found dead with multiple gunshot wounds to the chest.Assistant Prosecutor Larry Frye told the judge his office offered Pauley mercy based on his confession and cooperation with police after the incident.Rosiek's brother, Brad Booth, 46, of Ohio, spoke before Pauley was sentenced."I never thought in my mind once about mercy for you, but mercy for my niece," Booth said, referring to Rosiek's daughter, Misty Hall. "Just so she doesn't have to go through a trial."Pauley's 21-year-old daughter, Brittany, sat on the edge of her seat, leaning in close behind her father during the hearing, and said, "I love you, Dad," before his plea.Outside the judicial building before the hearing, Hall, 33, of Oak Hill confronted Brittany Pauley, and court officials separated the two families before and after the hearing."It must be nice to have her parent," Hall said through tears. "It's not fair she'll still be able to write him letters and visit him."Reach Kate White at email@example.com or 304-348-1723. Story Share Story Share Trending Now 1 Facebook founder visits Cabin Creek Health Systems 2 Teen pleads guilty to voluntary manslaughter in Oakes Field shooting 3 Reunions: Sept. 26, 2017 4 Safety shutoff disabled prior to June coal-mining death, report says 5 Huggins, WVU tap South Florida hoops talent Kanawha Valley's oldest mission trying to revive its legacy Previous Story As debate looms, Romney looks to Pennsylvania Next Story


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MECHANICSBURG, Pa. (WHTM) – Faulkner on the Carlisle Pike in Silver Spring Township is expanding.
"We are doing a lot of development a lot of new things for the community here in Silver Spring Township and we are just excited to be over here," said Jack Oyler, president of Faulkner Cadillac.
The dealership plans to build a new Cadillac dealership and to convert the former Sutliff Cadillac along Commerce Drive into a Dodge Ram facility. They have also started construction on a Subaru and Volkswagen facility next to their existing dealership on Carlisle Pike.
Faulkner's plans also include bringing in high-end, Italian-made Maserati and Alfa Romeo models. The showroom for those will be located at the old Cumberland Valley Motors site.
"This market is an up-and-coming market. People continue to move, especially to the West Shore. It's got great demographics, high income and we look at it as a great market for the higher end vehicles. We also have the accessibility, with the highways, to bring people in from other areas with 81 and 83 converging all right here," said Oyler. "People can come to one little mile stretch of road here and see a lot of different vehicles, and I think that is good for everyone."
The first phase of the project will be done next year.


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WASHINGTON - Defense attorneys for George Zimmerman released a response to President Barack Obama's remarks on "stand your ground" laws and how the Trayvon Martin verdict is affecting the community.
"We have listened to President Obama's comments about the verdict in the Zimmerman Case. People are focusing on this quote: 'Trayvon Martin could've been me 35 years ago.' To focus on this one line misses the nuances of the President's message, which includes comments about how African Americans view the Zimmerman Case in the context of the history of racial disparity in America," the defense wrote on their website, GZLegalCase.com.
"While we acknowledge and understand the racial context of this case, we challenge people to look closely and dispassionately at the facts. We believe those who look at the facts of the case without prejudice will see that it is a clear case of self-defense, and we are certain that those who take a closer look at the kind of person George Zimmerman is -- something we understand the Department of Justice is currently doing -- we are confident they will find a young man with with a diverse ethnic and racial background who is not a racist, a man who is, in fact, sensitive to the complex racial history of our country."
Read the full statement on the Zimmerman legal case website.
Obama spoke in a surprise appearance Friday at the White House, his first time appearing for a statement on the verdict since it was issued last Saturday. He said he has watched the discussion over the last week since the verdict.
"If I see any violence, I will remind folks that that dishonorable what happened to Trayvon Martin and his family," Obama said.
Obama says black Americans feel pain after the Martin verdict because of a "history that doesn't go away."
Obama says African Americans view the case through "a set of experiences and a history that doesn't go away." He says black men in particular are used to being feared and blacks see a disparity in the way they are treated under the law.
He says he also has heard drivers lock their doors and has seen women clutch their purses tighter when he walked by, before he was elected to public office.
Copyright 2013 by ClickOrlando.com. The Associated Press contributed to this report. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Ah, the backlash to the NHL's new campaign against jersey tucks has ramped up, and it is delightful.
First, Carolina Hurricanes winger Alex Semin was penalized for it on Wednesday night.
"We're aware of it. (Semin) wasn't doing it on purpose," Hurricanes head coach Kirk Muller said after the game (via Puck Daddy). "First time wearing the jerseys and (it) kinda just kept popping up. But they said they'd be strict on it and we're aware of it. We've just got to find a way to prevent it from happening."
Then Maple Leafs winger Joffrey Lupul joined in:
Who's gonna be the first ref to tell Jagr to un-tuck his jersey? C'mon— Joffrey Lupul (@JLupul) September 19, 2013
RT @JLupul: Who's gonna be the first ref to tell Jagr to un-tuck his jersey? C'mon // Hartnell said same about if Gretzky were playing.— Stephen Whyno (@SWhyno) September 19, 2013
This is after Alex Ovechkin and Patrice Bergeron reacted with varying degrees of distaste. Kris Letang wasn't thrilled, either.
We'll see over the next few weeks whether it actually turns into a real issue, rather than training camp filler. People are rarely happy about changes, especially when they seem pointless, but they also tend to adapt. Think about the lifespan on complaints about Facebook redesigns.
The bigger question, though, is whether there actually is a point, beyond the given "enforce one uniform rule, enforce them all" rationale—specifically, whether it's all a precursor to placing ads on the parts of jerseys that were once tucked.
If that were to happen anytime soon, all this will seem pretty silly. It's doubtful that it'd be totally forgotten, though. Pro (and college) sports are big businesses, and revenue is revenue. Just be honest about it—like the NBA.


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- Laboratory
- Professional Development
- Stem Network
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The 19th annual Women in Science Conference sponsored by the Regional Science Resource Center at the University of Massachusetts Medical School and the EcoTarium will be held on Saturday, March 21, 2015, from 9:00 AM to 3:00 PM. The goal of the conference is to expose 100 Worcester middle school young women to careers in science and engineering and to begin conversations with local women who use science in their professions.
The day begins at the Ecotarium with ten 45-minute concurrent interactive workshops led by the following women professionals: engineer, physician, research scientist, healthcare professional, and veterinarian, among others. Through demonstrations and group activities, the interactive workshops showed the students how science is used in the workplace. The presenters explain different entry levels to their careers and provide tips on courses of study and ways to prepare and train for their professions. The students rotate to different workshops so that each student is able to attend 3 of 10 possible workshops.
At the conclusion of the workshop session, the students are transported to the University of Massachusetts Medical School for a luncheon. The luncheon provides an opportunity for students and presenters to continue discussions in a more informal setting. Following lunch, the students listen to a keynote speech and participate in a question and answer period with the keynote speaker.
Curious about how to run a Women in Science Conference?
For further details, contact Karin Lebeau, Interim Director, Regional Science Resource Center, UMMS at (508) 856-1529 or firstname.lastname@example.com


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Putting on the Ritz (or Hilton, or Hyatt)
Take a ruthless look at your office. If it strikes you as less than impressive, client meetings there could harm your carefully honed image.
So you might want to capitalise on the style and status oozed by a fancy hotel. Yes, you can recruit the lobby or cafe of a five-star establishment as a makeshift venue that feels good and buffs your image. Just ask digital marketing agency owner Frederic Chanut, who is compiling a review of Sydney's top hotel lobbies.
Drawn to hotel lobbies' "refined, slower pace" compared to high-street cafes, Chanut judges hotels by several benchmarks. For starters, each prospective hub should be downtown, in case something comes up, forcing a venue shift.
Other location details he scrutinises are the distance from the client's office or the place of the last meeting. He looks for plentiful power plugs and wi-fi access, and a calm atmosphere. Chanut says carpets, plants and thick wallpaper are good because they soak up noise.
Ensure that the style matches your invitees, he says. His lobby review defines the design flavour of Sydney's Shangri-La as "Asian chic" and describes the Menzies as "old school" and Swissotel as "trendy flash". His coffee pricing figures range from $4.50 (Stamford) to $7.50 (Langham).
His top overall pick is Swissotel. It is secluded and features pods for privacy. The feel is "modern, trendy, upbeat", he says, adding that the staff are great.
His other favourite haunt is the Bistro Fax at the Radisson Blu Plaza near Wynyard. "Great location. Right mix of old and modern. Great staff. Probably one of the best spots to have a meeting." The worst spots, which he skips, are run-down or - at the other extreme - pretentious.
After you find a fit, if you are expecting more than three or four people, don't just waltz in – ring in advance, he says. Never schedule the meeting before 9am or after 4pm because then guests may be eating breakfast or checking in or out. "So it can get a little crowded and noisy and smelly." Arrive early to secure a spot and set up, armed with enough battery power to last the duration.
Resist the temptation to order any serious food or booze, unless you want to strike an after-hours drinks mood. But do not wait more than an hour to order coffee because that will bug staff.
"Get them in your pocket" through tipping and playing nice. Then, whenever you hold a meeting on their territory, "they will help you make the experience just right". Keep your client sweet by covering hospitality costs, Chanut suggests.
Typically, he spends $7 per hour per person, which may sound steep when advances in video conferencing mean you can run a meeting remotely for virtually nothing.
Still, the yen for a traditional, personal, human connection persists. Branding consultant Steven Lewis meets clients at the lobby of the Marriott on Sydney's Pitt Street because the staff are professional and unobtrusive, he says.
"They're not forever interrupting to ask if everything is all right or trying to get you to order something else. Drinking three cups of coffee in an hour isn't good for anyone," he notes.
In other lobbies he has tested, the staff are pushy. Or the vibe recalls a crowded shopping arcade.
Pick somewhere low-key, with ample seating – if all seats are taken it is embarrassing, Lewis says. He also warns against noise.
"Australian interior design does favour the hard surface, which is an acoustic nightmare," he explains, adding that the best hotels' coffee shops often occupy teeming, echo chamber-like marble lobbies. So a hotel "one rung down" might be better.
The key interior resource is comfortable chairs set at tables, Lewis says. A toilet also helps, he reckons.
For any client meeting, Lewis wears business gear or a smart-casual jeans ensemble. In contrast, at information technology-based hotel meetings, Chanut has worn thongs and T-shirt, but he still champions a suit: corporate attire.
"Act as if you are meant to be there," Chanut says, "not as if you were sneaking in: don't dress up as a bum or someone that just came out of the gym."
For more information on Australian hotels, visit The Australian Hotels Association.
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Technology Excellence Award Goes to Fairfax County
May 17, 2010
News Highlights
More Information
Fairfax County recently received top honors in the annual Public Technology Institute (PTI) 2009-2010 Solutions Awards, which recognizes local governments' excellence in technology. The county's honors were in the Web and E-government category for its efforts in engaging residents during the Fiscal Year 2010 Budget process.
"Our innovative outreach efforts allowed us to further engage the community during the FY 2010 budget process," said David J. Molchany, Fairfax County deputy county executive. "We will continue to reach out, exploring new technology to help us gather feedback and input on future budgets and other issues important to our residents."
Facing the challenge of eliminating a projected revenue shortfall of $650 million for the 2010 fiscal year, which began July 1, 2009, the county turned to its residents and employees for input.
The public and employees were encouraged to participate through community dialogue sessions and employee meetings; a media campaign; an outreach program utilizing social media; and a one-stop shop on the county's revamped website.
The county held 20 community dialogue sessions, attended by more than 700 members of the public and five employee brownbag lunch sessions. Concurrently, the county used online and telephone (integrated voice response) technology for public questions, comments and suggestions. More than 1,497 comments were recorded electronically.
The media campaign incorporated social media by posting information and videos on the county's Facebook and YouTube sites. It also used news releases, newspaper advertisements, fliers to school and community groups, posters in county and school facilities and video segments on Fairfax County Government Channel 16.
Public input continues to evolve. Twitter, a short messaging service designed for quick information sharing, was added to the FY2011 Budget process. In preparation for the FY 2012 Budget process the county plans to incorporate social voting and additional interactive opportunities.
Contact: Merni Fitzgerald, Director, Office of Public Affairs
703-324-3189, TTY 711, Media Pager: 703-324-NEWS (6397)
To request this information in an alternate format, call 703-324-3187, TTY 711


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CRADLEY took a massive step towards retaining their National League title by beating Coventry Storm at Monmore tonight.
The Heathens won the hard-fought contest 57-35 to get revenge against the third-placed team that beat them earlier in the season.
Cradley were in determined mood from the start and it only took until the second heat for them to bag their first maximum of the night when Nathan Greaves was followed home by Danny Phillips.
Despite the Heathens winning all but one of the first seven heats, Coventry were still in the contest approaching the half way stage.
Sefan Nielson claimed the away side's first victory in heat three on what would be a good night for him.
A crucial moment came when Cradley drew away with a 5-1 in heat nine when Max Clegg claimed the win ahead of team mate Tom Perry.
The home side weren't going to give away their lead from that point and asserted their strength as the match-up drew to a close.
Cradley wrapped things up in style by claiming 5-1 wins in the final three heats of the night.
The Starke and Worrall combination was responsible two of those wins as the Heathens continue to fly high at the top of the table.
CRADLEY 57: Paul Starke 15, Steve Worrall 10+2, Max Clegg 9+1, Nathan Greaves 9+1, Danny Phillips 6+2, Tom Perry 5+1, Matt Williamson 3
COVENTRY 35: Stefan Nielsen 15, Dan Greenwood 6+1, James Sarjeant 5, Oliver Greenwood 4+2, Ryan Terry-Daley 3+1, Martin Knuckey 2, Luke Crang r/r


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Download by size:Handphone Tablet Desktop (Original Size)
James | This website provides some of dining chair design references that you can try at home. Running out of some fresh ideas can affect the end result of your home interior design. Part of realising a dream home is to look for some nice ideas used as your inspirations for creating a good home with modern style. This website has plenty of dining chair design images that could be used as references for actualizing your dream modern home. There is an Dining Chair Design and some other stunning pictures that you could use as your base ideas for interior decoration.
Ever since the pictures featured here in this
dining chair design galleries are posted at April, 28 2017, the visitors count has been increasing. It has reached the number of view, which makes some of the ideas posted quite popular. Many of designs featured here are the creations of some of the most top notch interior designers, which makes the ideas even more iconic and interesting to try.
Some of the best dining chair design references here are also available in compact sizes, which makes them easier to be accessed through mobile and won't consume much of your disk space. The HD pictures are compressed with most of them are available at small, medium and large. This is the reason why downloading the pictures from this dining chair design gallery won't consume too much of your disk space. The Dining Chair Design here, for example, is available in HD version, as well as plentiful of other inspiring design photos here, but they are pretty compact and light.
20 modern dining room chairs – best comfortable dining chairs


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- Overview
- Specs
- Reviews
Castelli Women's Tenerissimo 2 TightsWith comfort you have to experience to believe, the Tenerissimo 2 women's cycling tights provide the wind resistance, warmth and stretch you need to ride in chilly conditions. Thermoflex fabric with a fleece interior provides insulation and protection from blustery winds. Ten panels move with your body and compress your muscle for increased power output. Kiss3 Donna chamois delivers all-day comfort, silicone grippers wrap securely around your shoes and ankle zippers make it easy to get in and out of these tights.
- Thermoflex fabric is a nylon/Lycra blend with a brushed interior and silicone finished exterior for warmth, stretch and light water repellency
- Temperature range: > 42° F < 58° F
- Anatomic 10-panel design maximizes muscle compression for pedaling efficiency
- Kiss3 Donna chamois:
- Women's specific design
- Super soft, brushed microfiber top for maximum comfort and fit
- Seamlessly engineered to eliminate chafing and abrasion
- Anatomical shape with flexible design moves with you
- Bacteriostatically treated to avoid saddle sores and friction
- Dual density and infinitely variable thickness for perfect cushioning through every part of the chamois
- Maximum thickness and density in the ischial zone, tapering to moderate thickness in the perineum, and minimum thickness at the perimeter
- Embossed Castelli writing on side of chamois
- YKK ankle cam-lock zippers with reflective tape for easy-on, easy-off
- Silicone ankle grippers lay flat and seal around shoe covers
Castelli Women's Tenerissimo 2 Tights
- chamois:
- Kiss3 Donna
- drawstring:
- None
- fabric:
- Thermoflex
- inseam:
- panels:
- 10
- video:
- 1F6AmmT2X7c
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January is national oatmeal month. Did you know that more people eat oats in January than any other month? (At least, according to some sources.) I have trouble buying it based on how often we talk to our customers about eating oatmeal. I've always known our customers are special- they eat oats all year round, many almost every day!
Whether you're a once-in-a-while oatmeal eater or the everyday sort, January is a great time to celebrate oatmeal! Most of us are already thinking about eating better and after spending almost 6 weeks indulging in holiday foods of every variety, oatmeal is good way to clean house.
Oats are not just delicious and soothing, but they also have some special qualities that provide incredible health benefits. Oats have been proved to reduce cholesterol and they're a great source of protein, dietary fiber, vitamins, minerals and phytonutrients.
Oats contain soluble fiber, which soaks up cholesterol in the intestines and prevents it from being absorbed, eventually carrying it out of the body. The body recognizes this decrease of cholesterol in the intestines and responds by pulling cholesterol out of the bloodstream to replace the cholesterol that was removed from the intestines (aren't our bodies amazing sometimes?). As a result, the amount of cholesterol in the bloodstream goes down and so does the risk of heart disease!
If that's not a good reason to enjoy oats, how about some of these?
- Bob's Favorite Scottish Oatcakes
- Hearty Oatmeal Bread
- Oregon Orchard Oats Brülé
- An Argentinian Love a Pear
In honor of National Oatmeal Month, I'm giving away an oat-themed gift pack to three lucky winners! Each gift pack will contain four of our favorite oat products! You have until midnight on January 21st, 2011 to enter. Winners will be selected at random using Random.org and announced on January 24th.
Here is how to enter:
Mandatory: Leave a comment here, on the blog, telling us why you love oatmeal. It doesn't have to be a love ballad, it can be simple.
For extra entries (you can do each of these only once, for a maximum of 5 entries including the mandatory entry): These can be posted here on the blog or on our facebook profile page (sorry, no tweets this time)
1 entry: Post a link to a recipe using oats that you think sounds delicious.
1 entry: Post an interesting fact about oats. It can be something about their nutritional benefits, how to use them, how they are grown, anything really.
2 entries: Write a haiku about oatmeal.
Go to it and celebrate oatmeal!


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My whole family LOVES Wreck It Ralph. There's so much TO love. There's sweet, there's funny, there's action, there's a love story…the underdog story, the surprise twist…and…my favorite…Sour Bill. I think he's one of my favorite Disney characters, ever! Now that Wreck it Ralph is out for purchase, we can watch again, and again, and then again.
All 3 kids insisted we wait 45 minutes in line to meet Ralph and Vanellope. They were not willing to wait that long to meet Mickey Mouse. That's got to speak volumes.
Haven't hear about Ralph? He's the "bad guy" in the arcade game "Fix it Felix" who wants to be the hero and have the accolades that Felix Jr. has. When the folks in his game don't want to see him as anything but the bad guy, Ralph leads his game and sets out to find a way to win a medal, so that the folks in his game will recognize him and see him as more than the bad guy. Of course, Ralph gets into situations and learns a whole lot of lessons along the way. He also meats some hilarious characters from all kinds of arcade games who interact in really neat ways- there's love, there's action and there's a whole lot of funny (see above reference to Sour Bill). Most of all, there's Vanellope von Sweetz, a spunky, sassy little "glitch" in the Sugar Rush Candy game at the arcade where Ralph ultimately lands. Their unlikely friendship tugs at your heartstrings and their joined sense of being outcast is just so sweet, and sets such a stage for a great story line.
I didn't even realize until I was grabbing the box art for this post that there are Hidden Mickeys in this movie- now we have to watch it again to find them! I should know better by now and always look for those hidden Mickeys…
Can't get to the arcade to play games this weekend? Check out these fun (and free!) Wreck it Ralph games and activities!
Thanks to Disney for the combo pack to review of Ralph! We may just wear this one out!0


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WATSONVILLE - Measure R, an initiative to levy a $5 monthly charge on mobile homeowners, was approved by voters Tuesday.
With a simply majority needed for passage, the measure won almost 56 percent of the vote.
The fee is designed to establish a legal defense fund for the city's mobile home rent-control ordinance. It will raise about $59,000 a year.
Mobile homeowners say the fund is needed so that they can protect their investments. City leaders supported the measure as a way to ensure a component of Watsonville's low-cost housing stock stays affordable.
About 2,500 people live in the city's 1,000 mobile homes, which sit in parks. Residents own the homes, but rent the space they sit on from park owners.
Under the ordinance, park owners are entitled to cost-of-living increases, but must provide a financial analysis to justify higher increases.
In recent years park owners and residents have clashed over rent increases, and the city has stepped in to ensure its ordinance governing rate increases was observed.
Similar battles in Capitola ended with leaders there repealing the ordinance in 2011 after spending more than $1 million during the previous decade to defend it.
Watsonville's City Council can't repeal the ordinance because it was enacted by voters and only voters can change it. That's why all registered voters were able to weigh in, even though only mobile homeowners would pay the fee.
There was no organized opposition.
Follow Sentinel reporter Donna Jones on Twitter at Twitter.com/DonnaJonesSCS
Measure R
This measure would impose a $5 monthly fee on mobile home owners to raise an estimated $59,000 annually to help cover the cost of defending against excessive rent increases.
Yes 3,593
No 2,850
22 of 22 precincts reporting


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Topic: Help. Lots of pain- beginning of end?
Hi. My mother is in extreme pain for the last week, and it is hard to tell what is caused by the cancer and what is associated with all the meds she's on.
A brief history: my mom was diagnosed as CC (specifically gallbladder cancer, but it is apparently very similar to bileduct, and that is where her initial large tumour was) stage IV in april 2012, went through 4 months of chemo, then abandoned it as it stopped being effective. In November she was told she probably had 4-7 months, but that she could travel if she felt up to it. As I'm in the uk and she was in Israel, we planned for her to come for the holiday season. She travelled a week ago, but hasn't left her bed since she arrived. Her pain levels were increasing a bit back home, and she has lots of meds (mostly codeine based) to control it; but since arriving here she has had to double or triple some doses, and even then it doesnt seem to make much of an impact.
I have seen some discussions here about constipation, and I do think this is playing a role. Her tummy is distended. She is on laxatives although they are not helping much, and I think she can probably shift to taking them more often. She is barely eating and we are struggling to get much fluid in her, so it is hard to know how much we should expect her to 'go'. Similarly she has lots of gas, and she is also taking something for that (simeticone).
What I wish I knew is how much of her current (constant as well as intermittent sharp) pains are to do with cancer and how much are result of constipation? And if she is in as much pain as this, does it signal the beginning of an end? Is this one of the signs?
I have already been in touch with her GP (=family doctor) back home who is monitoring her day to day, and he recommended tweaking some of her meds. That helped a little although now it seems not to be working. If she has a severe obstruction issue, is this something that requires hospitalisation to sort out? Shall I try bombarding her with laxatives first?
Any advice would be much appreciated.


text: Politics 31 January 2013 Leader: Cameron should not seek to be the heir to Blair in North Africa Sign up for our weekly email * Shortly after his election as Conservative leader, David Cameron is said to have described himself as "the heir to Blair". Rarely has this sobriquet seemed more appropriate than in the days following the Algerian hostage crisis and its bloody conclusion. In an uncanny echo of Mr Blair's rhetoric after the 11 September 2001 attacks, Mr Cameron spoke of a "generational struggle" against jihadism in North Africa, of an "existential threat" from groups that want to do the "biggest possible amount of damage to our interests and way of life" and of a global war that could last "decades". He ended his statement to the House of Commons on 21 January by declaring: "We must frustrate the terrorists with our security; we must beat them militarily." Mr Cameron's words are in part a necessary counsel against complacency. The west has been slow to recognise the emergence of new jihadist fronts across North and Central Africa. Only now is it acknowledged that the western intervention in Libya had the unintended consequence of allowing trained fighters and vast quantities of weapons to spill over into Algeria and Mali, where France deployed forces this month. Peter Bouckaert, the emergencies director of Human Rights Watch, described the proliferation of weapons out of Libya as being on "a scale greater than [in] any previous conflict". Malian army officers report being overrun by rebel forces equipped with anti-tank and anti-aircraft rockets smuggled in from Tripoli. The overthrow of Bashar al-Assad in Syria, where the jihadist group Jabhat al-Nusra is leading the rebellion against the Ba'athist government, could have similar consequences. After the uncomplicated euphoria that greeted the Arab spring, the west's calculus of risk has shifted. If the threat has previously been understated, Mr Cameron is in danger of committing the equal and opposite error of overstatement. In another echo of Mr Blair –who once declared, "If we don't fight [terrorism], it's going to come after us" – the Prime Minister told MPs, "We should be working with others to help make the world safe all over the place, Mali included, because if we do not, the threat there will grow and we will face it as well." Yet there is no evidence that the groups Mr Cameron to which refers, increasingly localised and fragmented in nature, are either willing or able to mount attacks in Europe. By emphasising the "global threat" from al-Qaeda and its surrogates, he is also in danger of replicating the greatest mistake of the "war on terror" – that of conflating groups with little or nothing in common. Largely disparate outfits should not be handed a banner of unity under which to shelter. In defining the conflict in Mali, Mr Cameron should have taken greater care to distinguish between the Tuareg separatists, who have been waging an insurgency against the central government since 1963, and al-Qaeda in the Islamic Maghreb, which opportunistically seized control of the revolt last year. A more nuanced tone has been struck by the US administration, which has highlighted the localised nature of the conflicts and has avoided rash talk of a threat to the western "way of life". In his second inaugural address, Barack Obama spoke of "a decade of war" coming to an end and declared: "Enduring security and lasting peace do not require perpetual war." For now, there remains a welcome gulf between Mr Cam - eron's rhetoric and his government's policy. He has wisely avoid committing British troops to the action in Mali and has emphasised the need to train local forces and address the political grievances that give rise to extremism. Yet the risk remains that Mr Cameron, like Mr Blair, will eventually be tempted to seek refuge from his domestic woes in foreign adventurism. Before making any further pronouncements, he should reread the thoughtful speech he delivered on foreign policy in 2006. "It is not responsible to try [to] polarise debate through simplistic exercises in political positioning," Mr Cameron said. "Foreign policy decisions are not black and white, something which the public well understands. We need a sense of balance, judgement and proportion in handling the complex and dangerous challenges of foreign and security policy in the 21st century." That is as true now as it was then. Although it is the neoconservatives in Mr Cameron's party who have dominated debate in recent times, there is a rich tradition of Tory pragmatism for the Prime Minister to draw from. If he is to avoid repeating the errors that characterised a decade of western foreign policymaking, his response must be defined by patience, caution and scepticism. The UK has paid a high price for reckless interventionism in recent years. It must not do so again. Subscribe from just £1 per issue This article first appeared in the 28 January 2013 issue of the New Statesman, After Chavez More


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John David Moore
Associate Professor of English
Office: 3771 - Coleman Hall
Email: email@example.com
Fall 2015 Office Hours: TR 9:30-11:00 a.m. & 12:30-2:00 p.m.
John David Moore's areas of teaching and research include children's literature and nineteenth-century British literature. He has received multiple grants from the Illinois Humanities Council. His scholarly writing has appeared in such journals as The Pre-Raphaelite Review, Bulletin of Research in the Humanities, and The Journal of the Midwest MLA. He is also a classically trained pianist.


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Hanley's first career walk-off homer douses Cubs
Bullpen comes through on a rare rainy night at Dodger Stadium
LOS ANGELES -- With free agency looming, riches await Hanley Ramirez if he keeps this up. He crushed his first career walk-off home run Saturday night, a three-run shot with two out in the bottom of the 12th inning to give the Dodgers a 5-2 win over the Cubs.
The rain-soaked highlights will feature Ramirez's blast off Blake Parker that landed, fittingly, in the Dodgers bullpen. It was the bullpen that had as much to do with this win as Ramirez, as much as Matt Kemp's fourth-inning two-run homer or starting pitcher Hyun-Jin Ryu's seven solid innings.
Ramirez got the hero's welcome at the plate and the dugout bubble party and the sports-drink shower, but just as deservedly it could have been winning pitcher Jamey Wright, the fifth Dodgers reliever.
After pitching one inning Friday night, Wright pitched two more Saturday to contain what has suddenly become a pitching emergency for the Dodgers.
Their bullpen -- which picked up 4 2/3 innings after Dan Haren's short start Friday night and lost Paul Maholm with a season-ending knee injury -- pitched five scoreless innings Saturday.
Here's the roll call: Brandon League, with two-thirds of an inning; J.P. Howell, with a critical strikeout of Luis Valbuena to strand a pair of inherited runners (he's allowed only two of 31 to score); Kenley Jansen with a scoreless ninth; Brian Wilson striking out Anthony Rizzo, Starlin Castro and Justin Ruggiano in the 10th; and the 39-year-old Wright finishing it up.
Paco Rodriguez was recalled to replace Maholm, but he pitched Friday night for Albuquerque and wasn't used Saturday night. Neither was Chris Perez.
The crisis could continue Sunday, when Josh Beckett makes his third start since returning from the disabled list with a hip impingement. He didn't get past the fifth inning in the other two starts, so a reliever callup could be upcoming, although how to make room for one won't be simple.
Having won seven of eight and restored the lead to 3 1/2 games, Dodgers management will juggle Minor League arms in and out until it can pull off a waiver deal for a veteran. In the meantime, they need to win more games like this one.
It came with a rare August rainstorm dampening Dodger Stadium over the final four innings. The winning rally started with Dee Gordon singling up the middle with two outs. After three pickoff attempts, Gordon stole second base on Parker's first pitch to Justin Turner, his 51st steal.
"Him getting in scoring position is really what causes the true stress because then they know every pitch they throw -- a dinker, a ball through the hole or something -- is game over," said manager Don Mattingly. "So Dee being able to get a stolen base there is really big for us."
Turner worked a full-count walk to bring up Ramirez, who clubbed the game-winner.
"I was watching the way they pitched to J.T. and they didn't want to pitch to him, so I know I got to come through," said Ramirez. "He just made a mistake, left something on top of the plate and I hit it out."
It was Ramirez's 12th homer of the year and first since June 17. He went 3-for-5 with a walk, double and homer and the walk-off.
Production from Ramirez and Kemp was essential, as the starting lineup was missing Yasiel Puig, Adrian Gonzalez and A.J. Ellis. Puig, nursing a hamstring, according to the club, came off the bench with a pinch-hit single, then was picked off. Gonzalez, with a scheduled day off, struck out as a pinch-hitter. Ellis has a bruised right knee and will probably miss Sunday's game as well.
"We're not a one-man band," said Mattingly. "There's no one guy that's going to keep us from moving forward."
Kemp turned the score around in the fourth inning, following Ramirez's leadoff walk by former Japanese League star Tsuyoshi Wada with a towering blast to left-center. Kemp has four homers in the last five games, is 7-for-18 on the homestand and 18-for-49 since the All-Star break.
"I feel good at the plate. I hit a couple balls hard tonight," said Kemp.
And coming off two injury-plagued seasons, the one-time ironman has now played in 100 games, tied for most by a Dodgers outfielder this year with Puig.
Ryu took a one-run lead into the seventh inning, which figured to be his last. With one out in the top of the inning Junior Lake bunted perfectly for a single and with two out was doubled home by Arismendy Alcantara to tie the game, Alcantara taking third base on the throw. A slick glove play by Turner, starting at first base for Gonzalez, robbed Coghlan of another hit and stranded Alcantara at third base.
Ryu was charged with two runs on nine hits in seven innings with six strikeouts.
Ken Gurnick is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.


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To validate titles to certain lands conveyed by Indians of the Five Civilized Tribes and to amend the Act entitled "An Act relative to restrictions applicable to Indians of the Five Civilized Tribes of Oklahoma", approved January 27, 1933, and to validate State court judgments in Oklahoma, and judgments of the United States District Court of the State of Oklahoma.
[Public Law 116]
Be it enacted by the Senate and House of Representatives of the United States of America in Congress assembled, That no conveyance made by an Indian of the Five Civilized Tribes on or after April 26, 1931, and prior to the date of enactment of this Act, of lands purchased prior to April 26, 1931, for the use and benefit of such Indian with funds derived from the sale of, or as income f rom, restricted allotted lands and conveyed to him by deed containing restrictions on alienation without the consent and approval of the Secretary of the Interior prior to April 26, 1931, shall be invalid because such conveyance was made without the consent and approval of the Secretary of the Interior: Provided, That all such conveyances made after the date of the enactment of this Act must have the consent and approval of the Secretary of the Interior: Provided further, That if any such conveyances are subject to attack upon grounds other than the insufficiency of approval or lack of approval such conveyances shall not be affected by this section.
Five Civilized Tribes.
Validation of certain conveyances.
SEC. 2. That nothing contained in the Act of January 27, 1933 (47 Stat. 777), shall be construed to impose restrictions on the alienation of lands or interests in land acquired by inheritance, devise, or in any other manner, by Indians of the Five Civilized Tribes, where such lands, or interest therein, were not restricted against alienation at the time of acquisition, and all conveyances executed by Indians of the Five Civilized Tribes after January 27, 1933, and before the date of approval of this section, of lands, or interests in lands, which, at the time of acquisition by them, were free from restrictions, are hereby confirmed and declared to be valid, irrespective of whether such conveyances were or were not approved by the Secretary of the Interior, or by any county court of the State of Oklahoma: Provided, That if any such conveyances are subject to attack upon grounds other than the insufficiency of approval or lack of approval such conveyances shall not be affected by this section: Provided further, That the provisions of this section shall not be construed to validate or confirm any conveyance made in violation of restrictions recited in any deed to lands purchased with the restricted or trust funds belonging to any Indian of the Five Civilized Tribes.
SEC. 3. That no order, judgment, or decree in partition made, entered, or rendered subsequent to the effective date of the Act of June 14, 1918 (40 Stat. 606), and prior to the effective date of this Act, and involving inherited restricted lands of enrolled and unenrolled members of the Five Civilized Tribes, shall be held null, void, invalid, or inoperative, nor shall any conveyance of any land pursuant to such order, judgment, or decree be held null, voild, invalid, or inoperative because the United States was not a party to such order, judgment, or decree, or to any of the proceedings in connection therewith, or because the United States, its agents, or officers, or any of them, was not served with any notice or process in connection therewith, and all such orders, judgments, decrees, and conveyances, which are subject to attach solely by reason of any of the infirmities enumerated by this section, are hereby confirmed, approved, and declared valid.
SEC. 4. If any provision of this Act or the application of such provision to any person or circumstances shall be held invalid, the validity of the remainder of the Act and the applicability of such provision to other person or circumstances shall not be affected thereby.
|Separability of provisions.