text:
A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women
This study has been completed.
National Cancer Institute (NCI)
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) )
ClinicalTrials.gov Identifier:
First received: March 6, 2009
Last updated: June 30, 2017
Last verified: February 1, 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Show Detailed Description
- Mutations detected in the BRCA1 or BRCA2 genes have been show to produce very high risks of breast and ovarian cancer (as high as 90% and 60%, respectively), as well as accompanying risks for several other types of cancer. Women who have these genetic anomalies and who do not have cancer are aware of their high-risk status, which can have an effect on their ability to make decisions about personal choices and health care.
- Researchers are interested in learning more about how people who know their cancer risk status make decisions on personal relationships, family formation, and risk-reduction options.
- To study young women s experiences and decision-making processes regarding family history, genetic testing, couple relationships, family formation, and cancer risk management within the context of their experiences as BRCA1/2 mutation carriers.
- Women between the ages of 18 and 35 years of age and older who have been identified as having a BRCA1 or BRCA2 mutation. Participants must be contemplating or have experienced couple relationships, family formation, and/or risk management and reduction.
- Participants must be willing to have their interviews digitally recorded
- Researchers will conduct between 30 and 50 telephone interviews of study participants. Each interview will be approximately 90 minutes in length. The interview consists of open-ended questions that ask about the participants and their experiences before, during, and after they underwent genetic testing for BRCA1/2.
- At least one focus group will be coordinated at a national conference for individuals who are aware of their genetically based cancer risk. If more than 25 individuals are interested in participating in the group, an additional focus group will be convened.
- No medical treatments are specifically offered as a part of this study.
|BRCA1 Gene BRCA2 Gene
|Study Type:
|Study Design:
|Observational Model: Family-Based
Time Perspective: Other
|Official Title:
|A Qualitative Exploration of the Impact of Positive BRCA 1/2 Mutation Status on the Lives of Young Women
Resource links provided by NLM:
MedlinePlus related topics: Genes and Gene TherapyU.S. FDA Resources
Further study details as provided by National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) ):
Primary Outcome Measures:
- Conduct follow-up telephone interviews with participantswho were newly-tested at the time of original data collection to increase understanding of their mutationpositive experience longitudinally. [ Time Frame: ongoing ]
- Conduct two (2) focus group sessions at the JoiningFORCES Annual Conference, focusing on the unique geneticcounseling and support needs of women who consider or undergo genetic testing for BRCA1/2 prior to age 25. [ Time Frame: ongoing ]
|Estimated Enrollment:
|Study Start Date:
|January 26, 2009
|Ages Eligible for Study:
|18 Years to 100 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
- Participants must be biologically female
- Participants must have reached their 18th birthday but not have passed their 35th birthday
- Participants must be able to speak and understand English with a level of fluency sufficient for completion of the recorded telephone interview
- Participants must have completed genetic testing for BRCA1/2 and received a positive test result (i.e., a deleterious or disease-related mutation was identified).
- Participants must have experienced or be contemplating/planning couple relationship(s), formation of a family, and/or utilization of risk management/reduction strategies at some point.
-Potential participants will be excluded from the study if they do not agree to have their interview or focus group contributions audio recorded.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00858078
Please refer to this study by its ClinicalTrials.gov identifier: NCT00858078
|United States, Maryland
|National Cancer Institute (NCI), 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Cancer Institute (NCI)
|Principal Investigator:
|Mark H Greene, M.D.
|National Cancer Institute (NCI)
More Information
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) ):
ClinicalTrials.gov processed this record on September 21, 2017
Werner-Lin A, Hoskins LM, Doyle MH, Greene MH. 'Cancer doesn't have an age': genetic testing and cancer risk management in BRCA1/2 mutation-positive women aged 18-24. Health (London). 2012 Nov;16(6):636-54. doi: 10.1177/1363459312442420. Epub 2012 Apr 30.
Hoskins LM, Roy KM, Greene MH. Toward a new understanding of risk perception among young female BRCA1/2 "previvors". Fam Syst Health. 2012 Mar;30(1):32-46. doi: 10.1037/a0027276.
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT00858078 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|March 6, 2009
|Last Updated:
|June 30, 2017
Keywords provided by National Institutes of Health Clinical Center (CC) ( National Cancer Institute (NCI) ):
Qualitative Research
Semi-Structured Telephone Interview
Psychosocial/Behavioral Research
Hereditary Cancer Risk
BRCA1 Gene
BRCA2 Gene
ClinicalTrials.gov processed this record on September 21, 2017


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Quotables from LATE NIGHT WITH JIMMY FALLON , Week of 1/14
Below, check out quotables from NBC's Late Night with Jimmy Fallon JANUARY 14 - 18:
Welcome to Late Night with Jimmy Fallon! We've got a great show. Here's what people are talking about. Last night, "Les Miserables" won the Golden Globe for best musical or comedy. The musical part was Anne Hathaway singing, and I'm guessing the comedy part was Russell Crowe singing.
I was actually at The Golden Globes last night. I got to present an award with Jay Leno. Yeah, and you know, he was so nice - when we were done, he personally drove me to the airport and made sure I got on my plane.
Did you guys see this? Taylor Swift was photographed alone at the Golden Globes. So you know what that means: (WHISPER) she's dating a ghost!
This is cool. Last night, "Brave" won the Golden Globe for best animated film. Although I thought it was a little weird that they gave the award for "Brave" to whoever was sitting next to Al Roker.
Everyone was talking about how cold it was on The Golden Globes red carpet, with temperatures in the low-50's. In fact it was so cold, Ryan Seacrest had to get his hair defrosted.
There were also some big football games this weekend. Did you guys watch any of these games? Some great games. On Saturday, the Ravens beat the Broncos 38-35 after two overtimes. I'm not saying it went too long, but even Jodie Foster was like, "Jeez, wrap it up."
Some political news. Let's get political. I heard that President Obama's inauguration will have its own iPhone app that includes a map to public restrooms. Or as Al Roker put it, "Download complete!" (Which is ALSO what he said after pooping his pants at the White House.)
Some music news. You guys like music? Black Sabbath is reuniting with Ozzy Osbourne for their first album together in 35 years. You can tell that they're getting up there, cuz now all Ozzy can do is gum at a bat's head for 30 seconds until it flies away.
Hey, I want to say congrats to 23-year-old Mallory Hagan from Brooklyn, New York, who won the Miss America Pageant on Saturday. You could tell she's from Brooklyn, cuz instead of saying she wanted world peace, she was like, (BROOKLYN) "War? Fugheddaboutit!"
And finally, I read that Republicans and Democrats are working on a new bill to streamline the healthcare system. It will reduce the cost of mammograms and prostate exams. But don't worry, they'll still be free at the airport.
Welcome to Late Night with Jimmy Fallon, everybody! You guys, everybody is talking about Oprah's interview with Lance Armstrong, where he finally admitted to doping. And get this - the interview supposedly lasted close to three hours. So it's sort of like a regular interview, but you know...on steroids.
Here's some political news. President Obama's inaugural parade will feature eight floats, including a Hawaii float to honor his birthplace, an Illinois float to honor the first lady's home state, and a Kenyan float just to mess with Republicans. ("Wait a second...He said he wasn't...")
Speaking of Obama. I heard the president will push for a path to citizenship for 11 million illegal immigrants in the U.S. Obama says it's all part of his plan to give every man, woman and child the chance to pay more taxes.
More news out of Washington. Education Secretary Arne Duncan announced that he will stay at the White House for President Obama's second term. He said his mission is to make the U.S. number one in education, and won't stop til our students are doing gooder.
Some movie news. MGM is coming out with a remake of the classic 1959 film "Ben-Hur." Yeah, you can tell it's a remake, cuz instead of being about a Jewish prince who is betrayed by his Roman friend, sent into slavery, and then seeks Revenge - it's just about sexy vampires.
Get this. On Sunday, an elderly man in Chicago accidentally crashed his car into an Apple Store. And not surprisingly, he didn't look any more confused than all the other elderly people inside the Apple Store. ("Where are the apples? This is a Macintosh?")
Did you see this? A week after calling A.J. McCarron's girlfriend beautiful, last night ESPN commentator Brent Musburger referred to a female sideline reporter as "really smokin'." Which explains why people are now referring to his career as "really over."
I read that NASA just spent 18 million dollars to add an extra room to the International Space Station. It could have been cheaper but NASA's wife demanded granite countertops.
And finally, a new survey found that 35 percent of Americans use the Internet to diagnose themselves instead of going to a doctor. While the rest go to the doctor and let him search for a diagnosis on the Internet.
Welcome to Late Night with Jimmy Fallon. I'm sorry if I seem a little distracted; I just confessed to Oprah that when I played T-ball in kindergarten, I was on Juicy-Juice.
Oprah's big interview with Lance Armstrong is getting a lot of attention. It's a pretty big deal, and Oprah said to get ready she prepared 112 questions. Yep, the first question was, "Did you use steroids?", while the next 111 questions were, "Oh, c'mon - you used steroids, right??"
And now they're saying Lance may be forced to return the endorsement money he received from the US Postal Service. Seriously? I'm pretty sure the only group that's lied more than Lance Armstrong is the U.S. Postal Service. "Yeah, it'll be there in 2-3 business days, don't worry about it."
Here's some political news. On Sunday, the White House will hold a private swearing-in ceremony for President Obama. Not to be outdone, on Sunday Republicans will hold a private swearing-AT ceremony for President Obama.
This was big. Tonight was the season premiere of "American Idol" with new judges Nicki Minaj and Mariah Carey. Yeah, viewers got to see all the crazy hair, the diva behavior...But enough about Ryan Seacrest.
Get this. A week after saying, "I'm not leaving Oregon for the NFL," Chip Kelly has agreed to be the head coach of the Philadelphia Eagles. Even Lance Armstrong was like, "Pick a story and stick with it man."
This is interesting. The beginning of the movie "Lincoln" has been slightly changed to explain the Civil War to foreign audiences. Or as Lincoln put it, "Yeah, woulda preferred a different ending."
And finally, officials in Pennsylvania are apologizing after a computer glitch printed the wrong fathers' names on 500 birth certificates. So congratulations to The Maury Povich Show for getting renewed for 20 more years!
Welcome to Late Night with Jimmy Fallon! Everyone's talking about this Manti Te'o story. Have you heard about this? Notre Dame linebacker Manti Te'o is being accused of making up an online girlfriend, and then lying about her death last year so that it would help him win the Heisman Trophy. Or as Manti Te'o put it, "I'm gonna have to talk to Oprah, aren't I??"
That's right, Manti Te'o's online girlfriend was a complete fabrication. When they heard that, nerds were like, "Man - even imaginary Girls only like jocks."
Here's some political news. In a recent attack ad, the NRA claims that President Obama cares about his own children more than he cares about other children. In response, President Obama was like, "Yeah, that's how families work."
This isn't good. Cirque du Soleil just announced that it is cutting 400 jobs. So on the downside, hundreds of clowns will lose their jobs; but on the bright side, it'll free up, like, two spaces in the parking lot.
I saw that this weekend is the 30th annual Adult Film Awards - which is often referred to as the Oscars of porn. Mainly because Ben Affleck wasn't nominated.
And finally, a doctor in Britain has created a mathematical formula, and calculated that next Monday is the saddest day of the year. Or as Makers of cookie dough ice cream call it, "the happiest day of the year!"
Welcome to Late Night with Jimmy Fallon! Here's what people are talking about. Did you guys see Oprah's Lance Armstrong interview last night? Well, a lot of people are saying that Lance said all the right things in the interview, but he seemed to lack emotion. Yeah, it's almost like he needed a little something for more energy. If only he could take something for that.
After their interview, Oprah said that Lance Armstrong was honest and contrite about his doping. "Yeah, I'll believe it when I see it," said Manti Te'o.
Here's some political news. Yesterday, Joe Biden defended the White House's gun-control initiative by saying that he actually has two guns himself. Then Biden was like, "And I never leave home without 'em."
Hey, this week was the season premiere of "American Idol." And this year people are able to nominate their talented friends who don't want to audition. Yeah, making someone try out for something they don't really want - or as Republicans call that, "the Romney plan."
Listen to this. The original Batmobile from the 1960s Batman series is expected to sell for five million dollars at an auction this weekend. So if you've got five million dollars and want to look like Batman, why not just become Batman?

subset: commoncrawl


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Two seasons ago, Brad Keselowski was a 25th-place driver, with one surprising restrictor-plate Cup win to his credit.
Today, he's in the midst of a battle for the Sprint Cup championship and a leading voice in the sport.
And he's also the 2012 NASCAR Illustrated Person of the Year.
Raise your hand if you saw his meteoric rise coming.
"I was thinking about that because two or three years ago when I was just running the Nationwide Series I had some run-ins with Denny Hamlin," Keselowski said. "The feedback I was getting was either, one, 'You're the antichrist,' or two, 'You're the savior of the sport because you race hard.' Nothing in between.
"So when I was thinking about this article, I was thinking, 'Good Lord, maybe I am the antichrist.'"
If you heard the cascade of laughter that followed, it'd be clear that among the things Keselowski doesn't take seriously is himself.
"I'm very confident that when this article comes out that there will be (those) that say: 'Brad, he's the (expletive) devil! I can't believe it. This is so stupid.'"
Here's why it's not. In addition to his on-track performance and his place in the garage, he's also taking part in important—and very hard—work through his Checkered Flag Foundation.
The catalyst behind Keselowski's nonprofit organization came from a friend named Lee. Lee's last name won't be revealed because Keselowski believes he'd prefer it that way. They met via sim racing on the Internet.
"We raced together online, just a good dude," Keselowski said. "We'd spend a little bit of time together right before he deployed. He was here for about a month and only made it a month in Afghanistan—he was on his second tour—and he ran over an IED (Improvised Explosive Device). He survived but he was pretty tore up and a bunch of guys that were with him didn't survive. He took it pretty hard."
Meanwhile, driving for Dale Earnhardt Jr.'s Nationwide Series team with the U.S. Navy as sponsor in 2008 helped solidify Keselowski's determination to do something meaningful, particularly after he visited the Naval Medical Center in San Diego.
"I always look for signs in life to point me to places and I usually don't react off of one sign but I react off of multiple," said Keselowski, whose cousin is a Navy SEAL. The signs were there.
Two years later, in 2010, he and Andrea Ross, who ran the Navy's NASCAR program, formed the foundation.
"A lot of people do donations and so forth for charitable acts and I can't stand that. It drives me crazy," said Keselowski, while "washing his hands" of it to emphasize the point. "I want to be a part in actually doing something. I wanted to put together a program that actually did something tangible."
PHOTOS: Brad Keselowski's work on and off the track
The lynchpin of the foundation is the Race To Recovery program. The three-day experiences take veterans to race weekends and culminate with a ride-along the day after the Cup race.
"We don't just raise money and then write checks," Ross, the CFF's executive director, said. "We get actively involved to try and make a difference in these individual lives. We believe in providing an experience that they're gonna remember and maybe it even inspires them to go on and do other cool stuff. We're often told by these individuals that this is the first time they've been out of the house three days in a row since being injured."
Home for Taylor Morris has been Walter Reed Medical Center in Bethesda, Md., after a brutal IED accident this spring in Afghanistan. Serving as a Navy Explosive Ordinance Disposal technician on his first tour of duty, Morris lost both legs, his left arm from the bicep down and his right hand on May 3. His days at Walter Reed consist largely of occupational therapy, wound care, physical therapy and working with the prosthetics that now act as limbs.
In late August, Morris flew from Bethesda to Bristol, Tenn., to participate in the CFF's final Race To Recovery event of 2012. Morris said he received more than just a respite from the rigors of rehabilitation during the Bristol race weekend. He also met Brendan Marrocco, the first veteran of the Iraq and Afghanistan wars to lose all four limbs and survive.
"He was able to give me advice on things he has been through now being out of the hospital and on his own. It is always beneficial to know some tricks of the trade," Morris said. "It was nice to get another adrenaline rush when I drove with Brad in his race car, something I had not experienced since my last gun fight.
"Things have been so dull and boring around the hospital compared to the high-intensity life I used to lead."
MORE: Keselowski calls on tough times to ease Chase pressures
The intensity resumed for Morris soon after his return trip from Bristol. In September, Morris and girlfriend Danielle Kelly appeared on "Today" and other national TV shows after their Internet pictorial "Love Story" went viral. They've been a couple since high school in Cedar Falls, Iowa, and have remained inseparable during the grueling recovery period. Their experience in Bristol marked Morris' first big public event since his life-altering accident overseas.
"It was great for both of us to be able to pack up for the weekend and have a trip planned for us that we didn't have to worry about a single thing besides relaxing and having fun," Kelly said. "It was such a carefree weekend; everything went so smoothly, which is exactly what we needed."
Ross pointed to Morris as a shining example of a program participant who's persevering through extraordinary challenges. The CFF's mission is to support those individuals who have "sacrificed greatly for America—including military members, veterans, first-responders and their families." Since its inception, the foundation has hosted or participated in events with the Wounded Warrior Project, the Armed Forces Foundation, the Paralyzed Veterans of America, the National Fallen Firefighters Foundation, the Detroit F.I.R.E. benefit team and the Veterans Administration.
Keselowski is reluctant to accept praise for the work his foundation does with veterans.
"That's the issue I have with most of these guys (not wanting attention) and I'm in a very similar place with them," he said. "It kind of goes back to the same thing that these guys do: They do their service and they're the ones that come back injured. They don't want a damn parade. They appreciate it, no different than me, I appreciate the attention that the media gives me for the foundation, but it's not a primary objective.
"If it was, I'd just donate money once every (expletive) week."
MORE: Should Keselowski have wrecked Jimmie Johnson at Texas?
You'll notice that Keselowski is not averse to using profanity to help make a point. But the 28-year-old driver tries to keep his Twitter feed free of it. The social medium and Keselowski's career have both gained steam in the past couple of years.
Who can forget Keselowski tweeting a picture of the fiery scene after Juan Pablo Montoya's car collided with a jet dryer in this year's Daytona 500? The explosive growth of Keselowski's Twitter followers—he gained nearly 150,000 from the night's events at Daytona—felt like a watershed moment. But it wasn't Keselowski's personal Twitter highlight of the year.
"My favorite moment was when we put on a contest for my sponsors and basically ran a Twitter truck at Daytona," he said. "You won the opportunity to be on it by following my sponsors and tweeting us back. And we were able to measure who tweeted us, get their names and we put them on the truck. The response I got from that was incredible—and it might not have been additional followers—but it just felt great to do something unique that was groundbreaking."
Contrary to what you might believe, too, Keselowski is not all that interested with the number of followers in his Twitter tribe (currently over 300,000 followers). The day before the interview for this story, he came across something that forced him to think in a different way.
"Somebody wrote: 'Who gives a (expletive) how many followers you have on Twitter? Hitler had millions of followers; Jesus had 12.' And I'm like, 'Damn, that's pretty profound,'" Keselowski said. "So now anytime someone asks me that question from here on out, I'd rather have good followers than a lot of followers."
Buttressed by Twitter and his residence in the Chase top 12, Keselowski has emerged as one of the leading voices in the sport.
Jeff Burton has long been acknowledged as a voice of reason inside the Cup garage. Now relegated to the role of elder statesman at 45, Burton was asked to assess Keselowski's ambassadorial efforts.
"The one thing about Brad is he'll talk about everything. He pulls the trigger a little quickly sometimes and that's fine. He's outspoken, he shouldn't change. He gives his opinion," Burton said. "Sometimes I think he should think a little bit more and get a little more educated about it before he states it. But I like the fact that he gives his opinion and I like the fact that he's willing to tell people what he thinks and why he thinks it.
"We need people like that in the garage. We don't need a bunch of watchers, we need doers."
— Keselowski: I didn't race Johnson 'dirty'
The fact that Keselowski's an introvert by nature doesn't seem to mesh with how much his voice is heard these days. Clearly, his words carry more weight given sustained success and being on the verge of a Sprint Cup title. Through eight Chase races, Jimmie Johnson leads Keselowski by seven points. But Keselowski has never failed to speak his mind.
"He doesn't mind conflict," Burton said. "He doesn't mind getting involved in it and I respect him for that, too. There's something to be said for people that can brush off the chatter and just pay attention to what their goals are and what they need to do."
Nowhere will you find more chatter than on Twitter.
"What upsets me is when people will write me and be so much in favor of their driver—let's say you had a run-in with them—that they can no longer see right or wrong," Keselowski said. "If I bumped him and he got out a (expletive) shotgun and shot me, they'd say you deserved that for messing with my boy. You're so much a fan of his and so divided in your fandom that you can't rationalize or have common sense."
Even with civility sometimes in short supply, Keselowski said his only real regret with Twitter is not joining sooner. There have been no scandals for him but he does have to watch himself on nights when his sponsor's product is flowing.
"My biggest drawback to being on Twitter from that standpoint is I have a tendency to be a bit of an antagonist and the liquid courage probably brings that out," he said. "I think the same rules hold true on Twitter as hold true in real life. Don't be an a--hole. It's just basic life 101, it's what you learned in kindergarten. Apply it to Twitter. Be yourself, be true, don't be a jerk and use common sense."
When you think of Miller Lite and the No. 2 car, Rusty Wallace also enters your mind. At 56, Wallace is exactly twice Keselowski's age and, also, his predecessor in the iconic Penske car. They are a generation apart, and the wisdom Wallace can offer Keselowski comes from a quarter century of on-the-job training at NASCAR's highest level. Human nature being what it is, Wallace intimated, sometimes your biggest enemy can reside within. The 1989 Cup champion with 55 career wins and a place in the NASCAR Hall of Fame come next February pinpointed one pitfall for Keselowski to avoid.
"Just being cocky," Wallace said. "I was cocky growing up, I felt like I was the best driver, and I was just a little bit sarcastic and cocky. I guess I learned to try to be humble (but) even right to the day I quit I still wasn't great at that. Try to be humble a little bit."
The point is not lost on Keselowski. He's uttered the words "success breeds respect" countless times but the flip side of that equation is equally important.
"Success also tears down one's humility and that's a challenge to try to sustain. It's important because without humility, you lose that ability to always improve," he said. "But as far as how success has changed me? I don't know; I feel the same. I feel like it changes the people around you, but I don't feel like it changes you."
It certainly adds to Keselowski's off-track demands. During the photo shoot for this issue's cover, Keselowski posed gingerly with the American flag. He refused to drape it around himself and watched to make sure it didn't touch the floor. He wanted to talk about using Old Glory as a metaphor and what it really meant.
Freedom. Sacrifice. Men such as Morris and Marrocco.
"Anyone who makes a sacrifice for the betterment of society, to me, is a hero," Keselowski said. "This particular group just does it in a way that requires a level of bravery and discipline that takes it to another level."
Keselowski was asked about his relationship with Lee, the catalyst for his foundation, and whether they keep in regular contact.
"No, not really. I wish I did," he said. "Maybe, in a way, keeping in touch with him is what I do with these other people."
— This story originally appeared in the December issue of NASCAR Illustrated, which is on newsstands now.


text:
Baby Essentials, Metallic Diaper Bag - Silver
by Baby Essentials | Item #: 512187 |
We're sorry, this item is not available in your selected Club. Check another Club
About this item
Baby Essentials Metallic Diaper Bag Tote and Changing Pad has a fun blue/gray zebra lining and a soft, cushy changing pad. It is loaded with pockets inside to keep you organized on the go. The outside pockets can hold all the things you need. The top zipper closure opens very wide so you have easy access to whatever you need quickly.
- Lightweight gunmetal gray pleather exterior
- Blue and gray zebra print lining
- Includes a cushioned changing pad
- Wide opening zipper closure
- 2 zip pockets on front for keys or pacifiers
- 2 easy access gusset pockets
- Large open back to hold changing pad
- Inside zipper pocket for mom's needs
- 4 large pockets inside to organize baby's things
- Easy to wipe clean
Assembled Country
Assembled Size
16.0"L x 12.5"W x 5.5"H
Component Country


text:
SFAI Artist Talks: Trenton Doyle Hancock
San Francisco Art Institute
Monday, April 15, 2013 at 7:30 PM (PDT)
Who's Going
San Francisco, California
London, United Kingdom
Florence, Italy
Event Details
About the Lecture
Trenton Doyle Hancock's intricate candy-colored prints, drawings, collaged felt paintings, and site-specific installations work together to tell the story of the Mounds—a group of bizarre mythical creatures that are the tragic protagonists of the artist's unfolding narrative between good and evil.
Influenced equally by the history of painting as by the pulp imagery of pop-culture, Hancock transforms traditionally formal decisions—such as the use of color, language, and pattern—into opportunities to create new characters, develop subplots, and convey symbolic meaning. Hancock's works are suffused with personal mythology presented at an operatic scale, often reinterpreting Biblical stories that the artist learned as a child from his family and local church community. His exuberant and subversive narratives employ a variety of cultural tropes, ranging in tone from comic-strip superhero battles to medieval morality plays, and influenced in style by Hieronymus Bosch, Max Ernst, Henry Darger, Philip Guston, and R. Crumb.
Artist Bio
Hancock was born in 1974 in Oklahoma City and raised in Paris, Texas. He earned his BFA from Texas A&M University, Commerce, and his MFA from the Tyler School of Art at Temple University, Philadelphia. Hancock was featured in the 2000 and 2002 Whitney Biennial exhibitions, becoming one of the youngest artists in history to participate in the prestigious survey. His work has been the subject of numerous one-person exhibitions and is in the permanent collections of prestigious museums including the Dallas Museum of Art; Museum of Fine Arts, Houston; The Metropolitan Museum of Art, New York; The Studio Museum in Harlem, New York; SFMOMA; and Museum Boijmans Van Beuningen, Rotterdam, The Netherlands. His mythology has also been translated to the stage in an original ballet, Cult of Color: Call to Color, commissioned by Ballet Austin and created by Hancock, choreographer Stephen Mills, and composer Graham Reynolds. Hancock lives and works in Houston. He is Winifred Johnson Clive Foundation Distinguished Visiting Fellow for Interdisciplinary Painting Practices at SFAI.
About the Visiting Artists and Scholars Lecture Series
SFAI's Visiting Artists and Scholars (VAS) lecture series provides students and faculty—as well as the wider Bay Area public—with direct exposure to major figures in contemporary global art and culture. It creates an open forum through which SFAI's students are challenged to go beyond basic canonical approaches to the study of art and to discover a global perspective that encourages conceptual and comparative approaches. In addition to the public lectures they give, visiting artists and scholars regularly engage with students in an immediate and active way, by teaching intensives or by participating in seminars, critiques, or colloquia.
All VAS lectures begin at 7:30 pm in the Lecture Hall on SFAI's 800 Chestnut Street campus. For a complete schedule of SFAI's lectures and events, please visit www.sfai.edu/events
Thank You!
SFAI's exhibitions and public programs—a component of which is the Visiting Artists and Scholars Lecture Series—are supported in part by the Grants for the Arts/San Francisco Hotel Tax Fund. The Winfred Johnson Clive Foundation Distinguished Visiting Fellowships in Interdisciplinary Painting Practices are funded by the Winifred Johnson Clive Foundation.
When & Where
San Francisco Art Institute
800 Chestnut St
San Francisco,
Monday, April 15, 2013 at 7:30 PM (PDT)
Add to my calendar
San Francisco Art Institute
Founded in 1871, San Francisco Art Institute is one of the nation's oldest and most prestigious schools of higher education in contemporary art.
We boast an illustrious list of faculty and alumni in all areas of focus. Most importantly, we have consistently held fast to a core philosophy of fostering creativity and critical thinking in an open, experimental, and interdisciplinary environment. At SFAI, we educate artists who will become the creative leaders of their generation.


text:
Boat Tests
- Outer Reef
- Outer Reef 700
- 2013
- Passagemaker
- 100 gal.
- 2/Northern Lights, 16 kW and 8 kW
- 71'6"
- 18'6"
- 5'0"
- 101,000 lb.
- 2/503-bhp Caterpillar C9 ACERT diesels
- 2/705-bhp Caterpillar C12 ACERT diesels
- 2,000 gal.
- 400 gal.
Layout Diagram
Noteworthy Options: ABT Trac 220 stabilizers, 15.5-hp Side-Power stern thruster, 36-inch built-in SeaStar barbecue grill, Glendinning 50-amp CableMaster with 75 feet of cable on foredeck.
The Numbers
|Outer Reef 700 - Final Boat Test Numbers*:
*Performance numbers provided by builder.
Ranges based on a theoretically continuous full fuel load to approximate a 10-percent reserve.
Noteworthy Options: ABT Trac 220 stabilizers, 15.5-hp Side-Power stern thruster, 36-inch built-in SeaStar barbecue grill, Glendinning 50-amp CableMaster with 75 feet of cable on foredeck.
Extended Horizons
Many builders say they are willing To accommodate all owner requests. But the Outer Reef 700 reveals the lengths that one builder will go to create a boat for every boater.
OK, I admit it. Size really does make a difference.
Lest you think you've picked up a copy of Hustler by mistake, let me hasten to say that a fine example of this dictum is the Outer Reef 70 seen on these pages. It is essentially a stretched version of the company's 65-footer, but, oh my, what a difference!
Not only do those 60 inches make a quantum improvement on the interior and on deck, they make the boat even more fuel efficient because of the longer waterline. It's a win-win that doesn't add appreciably to the price of the yacht and, as a result, Outer Reef hasn't sold a 65 since they introduced the 70.
When Outer Reef president, Jeff Druek, found that many of his customers loved a particular boat but "wanted it a bit longer," he made the decision that all of his hull molds would be longer than initially needed. The mold for the Outer Reef 65, for example, can be used to build a boat as long as 72 feet. "I refuse to just tack on an extension to an Outer Reef," he says, adding, "Every hull is monolithic one-piece construction."
At first, the requests for longer hulls came because people wanted cockpits added, either for fishing or just as water-level access for diving or boarding a tender. But when the opportunity came to stretch the 18-foot-6-inch-beam hull to create a non-cockpit 70 (actually 71 feet 6 inches), the die was cast.
The accommodations forward of amidships remain essentially unchanged by the extra length, leaving the full-beam master suite and the two guest cabins as they are on the 65. One optional layout on the 65 turned the lazarette into a two-bunk crew cabin with access either through a transom door or via a door in the hanging locker of the master stateroom. The transom door is less than ideal at sea or in bad weather, and no owner wants the crew trudging through his private quarters.
With the 70, however, the added length contributes 3 feet to the saloon and 2 feet to the aft deck (and lazarette), thus solving both problems. While there is still direct access to the crew's quarters and engine room through the transom for use in port, a much more civilized stairwell in the after corner of the saloon provides all-weather secure entry to the crew area.
One look around the crew area on the 70 and it's clear that Druek and the Outer Reef designers clearly understand the adage, "A happy captain makes a happy ship." Aboard Good Times, the 70 shown on these pages, the crew's quarters should make for a very happy captain and crew, indeed. A private captain's cabin with a queen-sized berth and direct access to a large head with shower is to port, and a comfortably sized crew cabin with bunks is to starboard, sharing the single head. The area also has a mini-galley to make it self-sufficient and, even if you don't want to carry a crew, this area makes perfect sense for teenagers to have some independence.
At this point, I need to make it clear that there is no such creature as a "standard" Outer Reef. Each and every one is tailored to the needs and desires of the owner, so the area abaft the engine room is really a blank sheet of paper waiting to be customized. One 70 under construction will have the beautifully finished captain's cabin but, since the owners plan to carry only a husband/wife crew, the rest of the lazarette will be fitted with a workbench and storage, plus scuba compressors and an extra freezer.
I don't want to jump around into different areas too much, but the added five feet also makes an immense difference in the boat deck abaft the flying bridge. This now allows for a tender as large as 20 feet to be chocked easily. With the tender launched and the chocks removed, you can host your high school reunion as well.
And then there is the saloon. An extra three feet allowed Druek and his design team to rethink the layout and add the crew stairs, and they turned the seating arrangement around from the one found on the 65.
As you enter the saloon from the shaded (and, on Good Times, soft-enclosed) afterdeck, you find low cabinets and an L-shaped settee to port, and a pair of bucket chairs to starboard. What you will first notice, however, is the sweep of vision without bulkheads from the entry doors all the way to the pilothouse windows. Large side windows and the openness make the 70 feel like a far larger yacht. Those side windows, by the way, are ⅜-inch tempered glass and those in the pilothouse are ½-inch tempered.
Guests now face aft, with a pop-up TV in the cabinet and a view through large windows over the afterdeck, which now has room for uncramped chairs around the large table.
The galley is amidships above the master suite, giving each space the benefit of minimum motion in a seaway. Druek stole a few inches from the saloon to expand the galley, which no longer features the U-shaped layout found on the 65 but instead a more interesting L-shaped arrangment. This allows for oversized granite counters (each with teak rails to contain spills) and a huge center island. But, and this is an important point for offshore cruisers, rearranging the galley put the counters close enough together so the cook can brace against pitching or rolling.
The appliances are all GE Monogram in stainless and, in addition to the usual items, include a dishwasher, trash compactor, and garbage disposal. A stand-up fridge plus drawer freezer is opposite the galley, which eliminates the dayhead usually tucked into this area under the stairs to the flying bridge. It's a personal call for each owner, but I sure like having a convenient head on the main deck. On the 65, I also liked the door from the dayhead to the side deck, for direct access from the outside without tracking through the saloon.
As I considered the delightful airiness created by the absence of bulkheads separating the saloon, galley, and pilothouse, it occurred to me that this could be a problem when running at night. Saloon lights, and certainly the big-screen TV, could cause distractions or reflections in the pilothouse windshield panels.
But Druek had the solution: one click of a remote button raised a solid teak bulkhead between the galley and the pilothouse to fully separate the skipper. A pocket door could also be installed but that wasn't chosen aboard Good Times. Anyway, a slick idea solves a problem.
The pilothouse is clearly the heart of the Outer Reef 70, and it's likely where guests will gather when underway. A large settee is raised behind the helm for good visibility, with a gorgeous teak table for drinks and munchies.
The skipper lives in lordly grandeur with a single centerline Stidd chair on a pedestal behind a surprisingly simple instrument panel. In an era when 30-footers are delivered with dashboards as complicated as those of Stealth bombers, this straightforward black panel had just a pair of Garmin monitors, twin Caterpillar engine read-outs, a row of rockers for necessary items like the triple wipers, and the joysticks for the ABT-Trac bow and stern thrusters. There is ample room for more nav or communication electronics, but I found the ergonomic simplicity quite refreshing.
To port of the helm on Good Times is a computer screen, remotes for the VHF, and a particularly nice touch: a lofty searail combined with hand holds so you can stand more securely.
Gentle stairs from the pilothouse curve down to the cabin deck, with an ample foyer that conceals a full-size washer and dryer. Nice touch: These appliances sit in a molded pan so that the inevitable leaks drain directly into the bilge rather than ruining the teak sole.
Directly across from the stairs is a guest cabin with double berth and en suite head that includes a full shower, while the VIP is forward with a lozenge-shaped berth and another pleasantly sized head with shower.
The master spans the full beam, with an athwartships queen-size berth, a dedicated computer desk, and an en suite head that runs along the port side. Clearly designed for long-distance cruising or living aboard, the stateroom has a full walk-in closet forward plus another walk-in closet on the after bulkhead. A watertight and soundproof door in the after closet leads into the engine room, allowing the owner easy access and providing an emergency exit from the engine room as well.
The flying bridge is pleasant, with an impeccably finished hardtop shading a pair of settees with tables. The skipper has another centerline pedestal chair behind a smaller version of the clean dashboard in the pilothouse. Separating the seating from the boat deck are a pair of fiberglass consoles that create an outdoor kitchen with barbecue, sink, fridge, and lots of stowage. Surrounding the boat deck are double stainless steel rails atop coamings, and the weldwork on these falls into the jewelry category. Each weld is fully polished and, in fact, the stainless steel fabrications, from the engine-room exhaust supports to the bow and side rails, are truly exceptional.
While the owner of Good Times doesn't have a Great Loop of the eastern U.S. in his immediate plans, Druek created a cleverly hinged electronics mast that reduces the air draft to just 20 feet, 6 inches. An almost invisible hinged panel at the back of the hardtop opens to allow the mast to swing backwards and, since this is not planned to be a regular occurrence, the mechanism relies on old-fashioned block-and-tackle gear rather than hydraulics. For an upcoming 70 that will transit even lower bridges, the Outer Reef team devised a way to lift the entire hardtop off and secure it to the foredeck, reducing the height of the yacht even further.
An enclosed bridge version of the 70 is also under construction, with a teak-lined skylounge and pilothouse instead of the open flying bridge. This allows the usual pilothouse to be turned into an area with a huge country galley and a wraparound dining table under the forward windows.
I've saved the engine room for dessert, because this is where cruising skippers are going to do their "oohs" and "aahs." It is, quite simply, superb. First, there is ample space between the twin Cat C9s to walk on the nonslip decking, and stainless steel rails protect you against hot or moving parts. Every possible maintenance point is readily accessible, and it's clear that (unlike most automobiles) this engine room was laid out by someone who has actually worked on engines. The twin 20-kW Northern Lights gensets (standard are
16 kW and 8 kW) are tucked aft in sound boxes, but these are also readily accessed without problems. This is an engine room where your service technicians may try to kiss you, so be prepared.
Several items particularly impressed me with their thoughtfulness. First, the dual fuel filters for each main and the genset filter were grouped together for easy access, and each used identical filters, so the variety of required spares is reduced. The fuel manifold system was a masterpiece of both careful labeling and intuitive layout, so there should be no wondering which valve to open or close. This particular 70 had an additional 650-gallon belly tank under the master stateroom (instead of the standard 300-gallon belly tank) as well as the two standard 850-gallon saddle tanks, and a combination fuel polisher/transfer pump that allows the tanks (all constructed of 6061 aluminum) to be balanced. Normally, I would expect the engines and gensets to draw from the saddle tanks, leaving the belly tank as a reserve that would also keep the center of gravity low.
A long list of standard equipment includes quality systems from TRAC stabilizers to Kahlenberg horns, Glendinning Cablemasters to the Maxwell windlass with CQR anchor.
The standard engines are 503-horsepower Caterpillar C9 ACERT diesels, and I can't imagine why you would want to opt for a pair of 705-horsepower C12 ACERTs because you'd just be pushing more water, burning more fuel and, in the end, you'd only move the hammer-down-flat-out top speed from 13.8 knots to 14 knots as shown on Outer Reef's own performance curves. Every owner needs to find his own "sweet spot" that balances how fast he wants to get somewhere with what he's willing to spend, but an Outer Reef 70 like Good Times (with the added tank) will take you more than 4,300 miles at a bit under 6 knots, or slightly less than 2,300 miles at nearly 9 knots. Your call.
Solidly built, comfortably arranged, and thoughtfully outfitted, the Outer Reef 70 should clearly be on your short list even if you're looking for a smaller offshore cruising yacht because, after all, size matters.
Click here for Outer Reef's contact information and index of articles ➤
Brokerage Listings Powered by BoatQuest.com
Click to see listings of Outer Reef Yachts currently for sale on BoatQuest.com. ➤
This article originally appeared in the January 2013 issue of Power & Motoryacht magazine.


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I had a really bad 2hrs of trying to sign on. For some reason my explorer wouldn't accpet the address with "www" in front, which is weird because it usually takes me to able towers when it's not there. But anyways.
Am I missing something? Did someone have a heart attack, and no one knows yet?
As I look through the list of new threads since last night, I also was checking the thread starter. Low and behold, NO SHADE!
For someone that screamed "the end is near" that seemed like it started in the preseason, he doesn't create his own thread? I would bet the farm that if the Colts lost last night, he would have had one up within the hour, along the lines of "I knew they'd just build us up even higher than the year before, before they let us all down. I'm DONE with the Colts." It would be like clockwork.
There's only one reason he's not around, I guess. Hope you make a speedy recovery, and I hope the nurses let you use a computer here soon.


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Kevin Johnson knew exactly what he wanted on Friday when he walked up to the counter at the Best Buy Mobile specialty store at the South Bay Galleria in Redondo Beach.
He asked for a fifth-generation iPod digital music player, pulled out more than $300 in cash and was finally able to cross off his daughter's name from his Christmas shopping list.
Johnson said procrastination and a lack of time has kept him from completing his holiday shopping.
"I'm going shopping this weekend. I'm going to shop till the last day," said Johnson, 36, a business owner who lives in Redondo Beach. "Every year I say I'm going to start early, but I never do."
For the final weekend before Christmas, retailers are expecting to stay busy until Christmas Eve to serve late shoppers.
The top-selling item at the Best Buy Mobile - and at electronics stores and websites nationwide - has been the iPad Mini.
"That's been what everybody has been asking for, but it's been real constrained so everybody keeps running out," said Rick Acosta, store manager at the compact version of the electronics superstore.
Acosta said that while his store was out of the iPad Mini, a new shipment could arrive any day to meet the demand of last-minute shoppers.
To motivate consumers to stop by Best Buy stores in the final days, the retailer started a sale for Friday and today on the Samsung Galaxy S3 cellphone for Sprint.
At Paseo Colorado, the tony open-air mall in Pasadena, retailers have seen strong sales this holiday season because of consumers' increased disposable income and good weather, mall General Manager Michael De Leon said.
This weekend should also be busy, he said.
"I definitely expect all of the shoppers who have earmarked a high-ticket item to come back and finally make that purchase, like high-priced jewelry, things of that nature," De Leon said. "Especially the guys, they tend to wait till the last minute."
The mall does not make a special promotion for these final days before Christmas, instead focusing on the start of this shopping season, De Leon said.
At RC Street Shop, a Long Beach hobby store, "We're expecting some big numbers" for the final weekend," manager Jeff Horton said.
"I think there's a lot of last-minute people," said Horton, who caters to hobbyists wanting to purchase or repair radio-controlled toy cars, airplanes and boats.
RC Street had no plans for special promotions in these final shopping days.
"At this point, pretty much all the decisions have been made. There's not a whole bunch that we can do to change it," he said.
On Friday at The Mulberry Cottage, a specialty boutique in Torrance, Leslie Hoop was poring over her computer screen and a stack of papers as she worked to fill online orders for jams and jellies, soaps and tiny collectable mouse figurines called Wee Forest Folk.
"It's crazy here. ... We just shipped hundreds of packages," said Hoop, the store's manager. "We expect to be busy for last-minute items. We still have plenty of stuff. It's just we're running out of some things."
Some of the sold-out items included cocoa, mulling spices and ornaments.
"We are open Christmas Eve for really last-minute people," she said. "A lot of men come in the last day and get a gift certificate because they've waited so long."
At Landis' Labyrinth, a small toy store in Manhattan Beach, Manager Maya Muckelroy greeted guests Friday. The shop had put an ad and coupon in the newspaper Friday in hopes of drawing shoppers who have not crossed off every name on their shopping lists.
But Muckelroy also had her eye on sales in the weeks and months after the holidays.
"A lot of last-minute shoppers and even people who are just starting to shop," Muckelroy said of this weekend's expected business. "I hope for new local customers to come in so they come back when they need something."
Follow Muhammed El-Hasan on Twitter at http://twitter.com/dailybreezebiz


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*Anthony R. Moore, 50, 1000 block of West Washington Blvd.
*Nathaniel W. Dickey, 57, 1200 block of W. Creighton Ave.
*Brenda M. Jones, 47, 7900 block Decatur Road
*Preonda M. Jones, 49, 7900 Decatur Road
*Travis Michael Bloom, 22, 7600 block of Bojrab Drive
*Adel Lois Buelow, 22, 1700 block of Hillside Avenue
*Nigel Ashton Brown, 22, 3100 block of Vance Avenue
*Angela Marie Fett, 40, of 300 block of Plaza Drive, Columbia City
Investigators said the defendants comprise an associated group that has engaged in at least two incidents of racketeering activity, in this case, theft by stealing payroll account information from Bane and Associates, Tower Staffing, and Master Spas. They then used this information to generate fraudulent payroll checks and were cashed at various merchant locations throughout Fort Wayne, according to court documents.
Each member of the group has been chargedwith the crime of corrupt business influence, a class C felony. Dickey, Moore, Brenda Jones, Preonda Jones, Buelow and Brown, also have been charged with theft, a class D felony.
According to court documents, the stores where the fraudulent checks were cashed were Kroger's, Walmart and Save-a-lot. The total amount of each check was sometimes as low as $468.72, but was typically in the high $490's. The amount of the check would then be split among the individuals who went to cash that check on that day.


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RICHMOND, Va. (AP) – Virginia gun sales surged to an apparent record high in 2012.
State police statistics on gun buyers' mandatory criminal-background checks showed that there were 432,387 gun transactions last year. That's a 35 percent jump from 2011 and the largest year-to-year increase in 20 years.
The Richmond Times-Dispatch reports that those in the industry say the spike was fueled in part by the summer repeal of the state's one-handgun-per-month law and fears of increased gun restrictions after December's school shooting in Connecticut.
Transactions in December rose 79 percent over the same month in 2011.
Not all checks represent the sale of a gun, as some customers buy multiple firearms and other checks involve people reclaiming firearms that had been pawned. Exact sales figures aren't recorded in Virginia.
(Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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Yes, it is an engagement ring, and it is amazing. After X Factor host Kelly Rowland sparked speculation last month with some new bling on her ring finger, she finally confirms that the giant sparkler on her left hand is, in fact, from her fiancé (and manager) Tim Witherspoon!
The star makes an appearance on The Queen Latifah Show Wednesday and can't contain her excitement or stop smiling as she shows off her 4-carat-plus cushion-cut sparkler. (Watch the clip here.)
RELATED: Get the latest on celebrity engagements here!
"He put a ring on it," she gushes. "We've kept [our relationship] very, very low — for years, to be completely honest." (And all that practice paid off: She's kept her engagement low-key, though we don't know how she refrained from posting that ring all over her Instagram).
So did he ask with a big, romantic gesture? Well, not exactly. "He asked me first on Skype, and I was like, 'We're so far away from each other!' [But] it was that simple to say yes. I have my best friend to ride through life with."
What do you think of Rowland's bauble? Are you surprised she kept her engagement a secret for so long?
–Brittany Talarico


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THE Blackburn-born star of the timeless and successful television series The Waltons is to be guest of honour at the first ever event of a fan club.
Actor and musician Jon Walmsley, 58 who played Jason Walton in all ten seasons of the family-based drama, was born and spent his early years in Blackburn.
His family moved to California when he was aged five, and he later successfully auditioned for the role of red-haired Jason in the series which ran from 1971 until 1981.
He is also an accomplished musician, having worked with the likes of Michael McDonald, Gregg Allman, Merle Haggard and Roger Daltrey.
Walmsley also returned to perform in all of the Waltons reunion projects during the 1980s and 1990s, as well as creating the voice of Christopher Robin for Disney's Winnie the Pooh cartoons.
He has been invited back to the UK by Martin Ashton of the Waltons Friendship Society for a special concert and show where he will meet fans.
Martin, said: "Jon is indeed Blackburn born and bred. The story I heard was that one of his brothers became ill and his family moved to California for the sunshine.
"He auditioned for the part and appeared in the series all the way through. He was a musical character and could often be seen playing the guitar.
"There's still a lot of fans of the show and we've got people coming to meet Jon from as far away as Germany for the fan club event.
"Jon will be interviewed live on stage before performing a short concert of his music and will sign Waltons memorabilia.
"The event is being held in Stratford-upon-Avon but Jon would like everyone from his home town to know he's returning to the UK."
The event is on Saturday, September 13 at Shottery Memorial Hall, Stratford from 1.30pm to 6.45pm Tickets range from £13 to £100 and are available at www.waltonsfriendshipsociety.com.


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Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
- The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than is commonly thought.
- Early treatment of children with ONH and GH-deficiency can prevent adverse outcomes.
- Determine the prevalence and types of endocrinopathies in children diagnosed with ONH.
- Correlate endocrine outcome with radiographic, ocular, and developmental findings in children with ONH.
- Examine the effect of GH treatment on growth and obesity in children with ONH, GH-deficiency, and either subnormal or normal growth compared to children with ONH that are not GH-deficient.
- Compare growth outcomes between children with isolated GH-deficiency and those with multiple hormone deficiencies.
|Growth Hormone Deficiency Septo-Optic Dysplasia Hypopituitarism
|Drug: Nutropin AQ
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
- Change in Anthropometric Measures Over Time [ Time Frame: Baseline and 36 months ]Primary outcome measures included change in stature, weight, BMI, and weight-for-stature z-scores over the course of the study. Z-score indicates how many standard deviations an element is from the mean. It is calculated as z = (x - µ) σ, where µ is the mean of the population, and σ is the standard deviation of the population. A positive z-score indicates a datum above the mean, while a negative z-score indicates a datum below the mean. All z-scores were obtained using Epi Info ™ 3.5.4. (Centers for Disease Control, Atlanta, GA).
|Study Start Date:
|December 2004
|Study Completion Date:
|February 2014
|Primary Completion Date:
|February 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment Group 1: Receiving GH Treatment
Treatment group assignment was based on subject's stature SDS relative to the mid-parental target height (MPTH) at baseline and subsequent classification as growth deceleration or normal growth. Subjects with growth deceleration were assigned to the GH treatment group in accordance with standard of care. Subjects with normal growth were randomized to treatment or to control (no intervention). The intervention was Nutropin AQ. The starting dose was calculated as 0.3 mg/kg/wk and subsequently modified based on observed length/height velocity and serum IGF-I levels.
Drug: Nutropin AQ
Daily injection. Dosage dependent on weight.
No Intervention: Treatment Group 2: Control
Treatment group assignment was based on subject's stature SDS relative to the mid-parental target height (MPTH) at baseline and subsequent classification as growth deceleration or normal growth. Subjects with normal growth were randomized to treatment or to control. The control group received no intervention; however, control subjects were switched (crossed over) to the GH replacement group if, during the course of the study, they met criteria for growth deceleration.
Detailed Description:
Subjects for this study will be recruited from active and newly enrolled subjects in our larger ONH study. The study duration is three years and we anticipate 38 subjects will enroll. Subjects will be recruited for this study if they present with either growth deceleration or at least one subnormal result for IGF-1 or IGFBP-3.
Baseline information collected includes: height, weight, head circumference, examinations by an endocrinologist and ophthalmologist, endocrine laboratory testing, fundus photography, electrophysiology testing, head MRI, and a developmental assessment. A glucagon stimulation test will be performed and subjects who are deemed GH-deficient and who have delayed growth will be assigned to GH treatment, in line with standard clinical practice. Those with normal growth but determined to be GH-deficient by a glucagon stimulation test will be randomized to treatment with GH vs control (no intervention; observation only).
Subjects assigned or randomized to treatment with GH will be provided with GH for the duration of their participation in the study. Enrolled subjects will return every four months to monitor progress. Subjects will undergo a physical examination at each visit, including height, weight, head circumference, and body fat. In addition, subjects assigned or randomized to growth hormone will have laboratory testing of thyroid, IGF-1 and IGFBP-3 hormones, and fasting lipid levels.
|Ages Eligible for Study:
|up to 5 Years (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- New subjects diagnosed with ONH less than or equal to 2 years of age and subjects actively enrolled (in currently approved prospective ONH study) will be eligible for enrollment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00140413
|United States, California
|Childrens Hospital Los Angeles
|Los Angeles, California, United States, 90027
|Principal Investigator:
|Mark Borchert, MD
|Childrens Hospital Los Angeles; University of Southern California
|Principal Investigator:
|Mitchell Geffner, MD
|Children's Hospital Los Angeles
Additional Information:
|Responsible Party:
|Mark Borchert, M.D., Pediatric Neuro-Ophthalmologist, Children's Hospital Los Angeles
|ClinicalTrials.gov Identifier:
|NCT00140413 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 31, 2005
|Results First Received:
|February 17, 2015
|Last Updated:
|March 27, 2015
Keywords provided by Mark Borchert, M.D., Children's Hospital Los Angeles:
Optic Nerve Hypoplasia
Additional relevant MeSH terms:
Endocrine System Diseases
Dwarfism, Pituitary
Septo-Optic Dysplasia
Bone Diseases, Developmental
Bone Diseases
Musculoskeletal Diseases
Bone Diseases, Endocrine
Pituitary Diseases
Hypothalamic Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Nervous System Malformations
Congenital Abnormalities
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


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Backstop Sanchez set for rehab assignment
NEW YORK -- Giants reserve catcher Hector Sanchez is expected to join the Fresno Grizzlies, San Francisco's Triple-A affiliate, for an injury rehabilitation assignment.
Sanchez, who worked out before the Giants' series finale Monday in New York, will likely join the Grizzlies for the conclusion of a two-game series against Salt Lake City on Tuesday in Fresno. After a scheduled off-day Wednesday, Fresno will travel to Tacoma for a five-day series starting Thursday.
Sanchez, 24, has performed increasing levels of baseball-related activities as he has shaken off the effects of a concussion that sent him to the DL on July 26. But, as Giants manager Bruce Bochy said, "He needs to go over there and get in playing shape."
Sanchez hit .196 with three homers and 28 RBIs in 66 games before being sidelined.
Chris Haft is a reporter for MLB.com. Read his blog, Haft-Baked Ideas, and follow him on Twitter at @sfgiantsbeat. This story was not subject to the approval of Major League Baseball or its clubs.


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Tigers were already gonna win the central by 10 games. Now they should win by 15-20 and be WS contenders. Cabrera is moving Prince is playing 1B can Miggy still play 3B or LF?? We shall see the offense will be deadly defense wont be great though.
Hopefully now the Tigers give in andd trade Turner and other spects for Matt Garza.


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One change I made in the recipe directions was to simmer the lemongrass, kaffir lime leaves, ginger, Thai chiles, and garlic in the chicken stock for a bit, and then remove them. I recommend that step, even if it makes the soup slightly less authentic, especially if you're cooking for someone who's not familiar with Thai food and won't know that those flavorings aren't meant to be eaten.
The two uniquely Thai flavorings here are lemongrass, also used in Vietnamese cuisine, and Kaffir Lime leaves. Lemongrass is a perennial herb, called Takrai in Thailand. Mostly the inner white part of the stalks is used for flavoring. It can be frozen, and is also sold dried or powdered. Where I live it's hard to find fresh, but when I was visiting St. Louis recently I found some sliced, bottled lemongrass that worked well for this recipe. Kaffir lime leaves are the leaves of a Southeast Asian citrus plant, and they are never eaten, but used to flavor broth as I've done here. I'm lucky enough to have a stepsister in California who sends me these from her tree. If you're not familiar with Thai ingredients yourself, this page about Thai ingredients might be helpful.
(If all these Thai ingredients are a bit intimidating to you, you might want to visit an Asian market and try some of the packets of seasoning used to make soup like this. Of course, they aren't as good as making the soup fresh, but if you choose a brand that's imported from Asia, often they're quite good.
Thai Chicken Soup Recipe
(4 main course servings, recipe only slightly adapted from Eat This Book, Cooking with Global Fresh Flavors by Tyler Florence)
1 quart chicken stock, homemade or canned
1 lemongrass stalk, white part, crushed slightly or 1 tsp. bottled sliced lemongrass
3 kaffir lime leaves
(I don't use them often, so I keep them in the freezer.)
several slices ginger root
2 small fresh Thai chiles, halved lengthwise
(I keep these in the freezer too.)
2 large garlic cloves, smashed
1 can (14.5 oz.) coconut milk
(I used Thai Kitchen brand light coconut milk)
1 T Thai fish sauce (recipe called for 2 T)
(Thai fish sauce is nam pla)
1 1/2 tsp. sugar or Splenda
1 can mushrooms (recipe called for straw mushrooms)
2 cups shredded cooked chicken (4 cooked chicken breasts)
juice of 4 limes
fresh ground black pepper to taste
1/4 cup fresh cilantro to garnish if desired (or more)
In large soup pot, bring chicken stock to a simmer over medium heat. Add lemongrass, kaffir lime leaves, ginger slices, Thai chiles, and smashed garlic cloves. Simmer, covered, for 10-15 minutes, then strain stock to remove these inedible flavorings.
Turn heat to low, then stir in coconut milk, fish sauce, sugar or Splenda, mushrooms, shredded chicken, lime juice, and cracked pepper. Simmer about 5 minutes without boiling to blend flavors and heat chicken through. Ladle soup into individual bowls and sprinkle with cilantro if desired.
South Beach Suggestions:
This soup is perfect for any phase of The South Beach Diet, especially if you used light coconut milk. If you wanted the soup as part of an Asian meal, it would pair well with Thai Barbecue Chicken with Cilantro or Chicken Lettuce Wraps by Rand. If you add rice for phase 2 or 3, use Uncle Ben's Converted Rice.
Of course, you're all smart enough to figure out that this is my post for Weekend Herb Blogging, which is being hosted by Fiber of 28 Cooks this week.


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ARLINGTON, Texas—There's no stopping Landon Donovan.
The LA Galaxy star continued his strong run of form after threatening retirement following the 2012-13 MLS season with a pair of goals and an assist to guide the Americans to a convincing 3-1 victory over Honduras in the Gold Cup semifinals at Cowboys Stadium on Wednesday night.
"I have told him in our conversations that 'I measure you. Your benchmark is the best Landon Donovan ever,'" U.S. coach Jurgen Klinsmann said. "I'm not taking anything less than that. And he is trying to catch up with that. Give him more games. Give him time."
Playing with the U.S. "B" team during the Gold Cup after stepping away from the game last winter, Donovan has likely earned a spot on next summer's World Cup roster after recording seven goals and nine assists in the team's last six matches - five of which were in the CONCACAF tournament.
As a result of his presence after missing out on the last couple World Cup qualifying camps, the United States—which has outscored its Gold Cup opponents 19-4—extended its record winning streak to 10 games with a meeting with Panama in Sunday's final at Soldier Field on the horizon.
"I think we all are very, very pleased with the way (Donovan is) playing, and the way he's proving the point that he's hungry to come back into our picture, and [we're] obviously going forward towards the World Cup qualifiers," Klinsmann said.
Eddie Johnson scored the opener for the USA and Donovan twice provided the Stars and Stripes a two-goal lead against Honduras, which gave the host nation a scare early in the second half when Nery Medina scored on a header off a set piece.
In a bit of controversy, Klinsmann was tossed out of the game in the 87th minute after arguing what he thought was a hard foul on DaMarcus Beasley. There's a chance he could be suspended for the final depending on what an 11-person CONCACAF disciplinary committee decides over the next two days.
If he is ruled out, the U.S. will be in a hole without its boss who has the team rolling one year before the 2014 World Cup in Brazil
Klinsmann made three changes in his lineup from the USA's 5-1 victory over El Salvador in the semifinals on Sunday. Johnson replaced Chris Wondolowski up front, Alejandro Bedoya took over for Joe Corona and Stuart Holden moved ahead of Mix Diskerud in the midfield.
The changes paid off early on.
In just the 11th minute, Johnson worked a combo play with Donovan in the midfield that eventually led to the speedy Seattle Sounders striker finding himself with a clear path to the goal for an easy strike to open up the scoring.
Johnson, who was one of four players named to the Gold Cup roster prior to the knockout stage, now has two goals in two Gold Cup games. As a second-half substitute in the semifinals, it took Johnson just 14 seconds to score against El Salvador.
"I'm not going to lie, I like it on the wing now," Johnson said. "But I got called upon to play up top with Landon, who is a fantastic player, and playing with him, and his movement off the ball and his vision is first-class."
In the 27th minute, it was Donovan's turn to get on the scoreboard thanks to a quality set up from Bedoya, who had a nice first touch off a long pass before tapping it to Donovan. Staying onside, Donovan played the ball off his chest and slid it past goalkeeper Donis Escober.
The United States dominated throughout, but the Central Americans did manage to cause some concern shortly after halftime.
Medina scored his first international goal in his 10-year career off a set-piece cross from Marvin Chávez in the 52nd minute, but the pressure on the Yanks wouldn't last long.
Donovan quickly answered thanks to another solid play from Bedoya, who received a ball over the top of Honduras' back line before finding the onrushing Donovan at the top of the six-yard box for his second goal of the game.
"The first 30 minutes was brilliant football. Brilliant, high pressure, high tempo," Klinsmann said. "We wanted to move the football around and create chances, and that's what we did."
Entering the game Donovan was the only U.S. player to play every minute of every game. He was subbed out for Wondolowski in the 72nd minute after playing a role in each of his team's goals.
"It's the most relaxed I've felt," Donovan said. "I feel good, and I'm really enjoying it."
The United States will hope Donovan continues his leadership in the final, especially since Klinsmann may not be on the sideline after getting booted out of the game for arguing with referee Walter Quesadain front of the U.S. bench.
"It was just a reaction out of frustration, because fouls have added up throughout the last half an hour." Klinsmann said. "One really bad one actually right after the goal and then came this foul from Bease with two guys coming into him from behind, and I just kind of over boiled it."
The disciplinary committee was noncommittal on a decision after the game and said it will review the incident over the next 24-48 hours and make a decision if Klinsmann will be able stand on the sideline for the next game.
"I apologize for that reaction," Klinsmann said. "It was not meant against the referee, against nobody, because you feel for the health of your player in that moment."


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wipe (one's) slate clean(redirected from wiping your slate clean)
wipe (one's) slate clean
To erase the record of one's wrong-doings, likened to wiping the contents off of a piece of slate, formerly used as a reusable writing surface. I had been late a bunch of times, but after he heard that I'd been struggling so much at home, my boss said he would wipe my slate clean. Mom said she would wipe your slate clean if you pay for the vase you broke.


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34 35th St., Unit 26, Brooklyn, NY, 11232
Slava Balasanov
|Eyebeam CV
Slava Balasanov is a musician and visual artist working in the realm of digital culture and technology. He co-founded and operates Moment Sound Recordings and his music has been released on labels such as Mathematics Recordings, Future Times, !K7 and featured in Pitchfork, Xlr8r and Fader magazines. As an artist, Slava focuses on the convergence of real and virtual space, creating fantastic objects that playfully reveal the absurdities of common-place conventions of contemporary society. Often times the technology he develops for his projects evolves into large-scale collaborative platforms for creation and distribution of media online and on mobile devices. Slava holds a B.S. in Mathematics from the University of Chicago and a Master's Degree from the Interactive Telecommunications Program at NYU.


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Command system for training and stage directions
Synexis helps you communicate your training instructions and stage directions.
The loud shouting of instructions is a thing of the past. Be it for sport, driver training or for giving instructions on large, noisy machines – the Synexis wireless system is the perfect companion wherever training instructions need to be communicated. The Synexis Command System even allows instructions from trainers and experts to be understood over larger distances or loud background noise. This will help you create a positive training environment, carry out training exercises to the maximum effect, and achieve teaching objectives more effectively. Synexis can be used for all kinds of stage directions, for example to coordinate several people.
beyerdynamic Synexis coordinates the play of 150 drummers
At the anniversary of the drummer's focus school in Munich, 150 drummers receive commands via the wireless Synexis system to ensure they start playing simultaneously.
beyerdynamic's Synexis system ensures the smooth-running of St. Blasien Cathedral Festival
The wireless Synexis system was used for behind-the-scenes technical directions for the Cathedral Festival in St. Blasien.
For training such as
- Equestrian sport
- Rowing
- Traffic practice areal
- Dog training field
- Instructions at machines
- Synexis TP8 (USA TP2) beltpack transmitter
- TG H54c neckworn microphone
- Synexis RP8 (USA RP2) beltpack receiver
- DT 1 S single-sided headphone
- Battery-powered or with optional charger: Synexis CHP charger for one transmitter/receiver or Synexis C10 when using several receivers


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Contact Us
About Harvey Pratt
Considered one of the leading forensic artists in the United States, Harvey has spent over 50 years in law enforcement, completing thousands of witness description drawings and hundreds of soft tissue reconstructions. His work has assisted in thousands of arrests and hundreds of identification of unidentified human remains throughout America. Retired as the police forensic artist for the Oklahoma State Bureau of Investigation (OSBI), Harvey still responds to agencies that request his assistance.
Harvey began his career with the Midwest City Police Department in 1965 where he did his first witness description drawing a year later. This first attempt in forensic arts resulted in an arrest and conviction. He joined the OSBI in 1972 as a narcotics investigator and retired in 1992 as an Assistant Director. His expertise in witness description drawing, skull reconstruction, skull tracing, age progression, soft tissue postmortem drawing and restoration of photographs and videos have aided law enforcement agencies both nationally and internationally. Harvey's skills have assisted law enforcement in many high profile cases. A few of those cases are as follows: Green River Killer (Gary Ridgeway), BTK Killer (Dennis Rader), Oklahoma Girl Scout Murders (Gene Leroy Hart), Henry Lee Lucas and Ottis Toole, Bobby Joe Long, I-5 Killer (Randall Woodfield), Tommy Lynn Sells, World Trade Center 1993 bombing, Sirloin Stockade Murders (Roger Dale Stafford, Verna Stafford and Harold Stafford), Joe Fischer, Tommy Ward and Karl Fontenot, Roger Wheeler Murder (Winter Hill Gang case – James J. "Whitey" Bulger, Stephen Flemmi and Johnny Martorano), the Oklahoma City Bombing of the Alfred P. Murrah Federal Building, Donald Eugene Webb, Oklahoma State Fair Abducted Girls (Roy Russell Long), the Weather Underground Organization and Randolph Dial.
Harvey also aides investigations though training classes, besides lecturing before universities, colleges, schools and civic groups.
Harvey is a Cheyenne and Arapaho tribal member and is recognized as an accomplished master Native American Indian artist. He has won numerous awards and was named the Red Earth 2005 Honored One. He is a self taught, multi-talented artist involved in many media; oil, acrylic, watercolor, metal, clay and wood.
He has been recognized by the Cheyenne People as an Outstanding Southern Cheyenne. His family is an artistic and traditional Native American family. Harvey received one of the highest honors by being inducted in the Southern Cheyenne Chief's Lodge as one of their traditional Peace Chiefs.
Special Project
Oklahoma Centennial Blanket
More Info
Bigfoot Sculpture
"My Dark Passenger"
The Hoopa Project
The Hoopa Project Book
More Info
© 2008, Harvey Phillip Pratt Art, LLC
All Native American art images on this website are the property of Harvey Phillip Pratt Art LLC. Any attempt to copy, distribute, or sell the Native American art images presented on this website without express written and legal consent of Harvey Phillip Pratt Art LLC, will be subject to prosecution and punishment. All rights reserved.


text: OverviewBack to top Lavera - Natural Liquid Foundation Ivory - 1 oz. Item# :113605UPC# :4021457210060 Brand:Lavera Size/Form:1 oz. Ship Weight:0.10 Lavera Natural Liquid Foundation Ivory 1 oz. (30 ml) Lavera Trend Sensitive Natural Liquid Foundation Ivory is a hydrating foundation that blends easily to hide imperfections, creating a porcelain-smooth canvas. Free-radical fighting argan oil, organic blossom butter and vitamins A,C, & E protect, rejuvenate and nourish your skin. At Lavera, their extensive range of organic liquid foundation and organic tinted moisturizers are rated "best liquid foundation" by Natural Solutions! If you're looking for a healthy glow and natural look, Lavera organic tinted moisturizers are the perfect solution. Made with pure plant extracts, their organic liquid foundation deeply hydrates for a natural, radiant look. Lavera helps you get "the look" naturally, by enhancing your natural beauty. From sultry smoky eyes to red-hot lips, Lavera has everything you need to try out the trends for the season. Lavera's new fall cosmetics will help you get the look naturally - no chemicals necessary. Lavera Cosmetics are developed with good-for-you ingredients such as organic oils and flower extracts. Lavera develops every formula according to the strictest possible standards of natural quality, offering products that are as green as they are effective. Lavera trades in harmful synthetics like parabens, emulsifiers, petroleum, phthalates, lead, synthetic preservatives and fragrances for natural, effective, plant-based alternatives that are certified organic whenever possible. Every cruelty-free, biodegradable product represents a smart, gentle choice for the skin, body and planet. All Lavera organic cosmetics are certified 100% natural and contain certified organic ingredients. All Lavera natural makeup is cruelty-free, paraben-free and lead-free. In fact, you can't find another brand of organic makeup that's as safe for you and fashionable too! The Trend Organic Cosmetic line includes eye and lip products, foundations and powders and is the best performing organic mineral make-up line. Lavera Skin Care North America is the exclusive export partner for the Lavera Brand in North America. These products are innovative and are following mainstream marketing trends, yet at the same time are produced following the strictest natural ingredient standards in Europe. Lavera fully discloses all ingredients on each product and sample. It is approved by the BDIH foundation in Germany to comply with the strictest standards for natural skin care. Lavera and LAVERÉ products are: Designed for sensitive skin Made with pure, organic plant oils, herb and flower extracts Free from parabens, SLS and synthetic preservatives Free from fragrances, emulsifiers and petroleum based ingredients Cruelty Free, Gluten Free, GMO Free Truly natural cosmetics, not just another pretty tube in the bathroom! It's a serious business making sure you and your family are safe from potentially harmful ingredients that pervade the majority of personal care products! To make sure they keep themselves up to the task, Levara subjects their contents and production processes to the ultimate in independent scrutiny. You may not have heard about the strict guidelines for the Certified Natural Cosmetics set by BDIH set by BDIH in Germany, but it's the toughest certification process anywhere in the world for making sure products are natural and organic. Highly awarded from independent institutions in Europe! Lavera was ranked #1 in a study on safe cosmetics conducted by Oeko-Test Magazine, an influential consumer advocacy magazine in Germany, beating out 32 natural and mainstream manufacturers. In addition, Lavera has received more than 150 Oeko-test awards in the category "Recommended/Very Good", more than any other manufacturer of cosmetics! The tests done by independent institutions and judges and the resulting awards prove their commitment to highest quality. Lavera was the first manufacturer to provide 100% mineral based Sun protection. They received the "Innovation Prize of the Year" award in Europe at the Biofach — the largest natural product expo worldwide — several years in a row.


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Take a virtual tour of 18 rooms at the National Gallery. Get closer to the paintings: choose fullscreen for an even better view.
See more in 360º
Three Titian masterpieces were united in the multi-arts project
'Metamorphosis: Titian 2012' – you can still see them hung together in our
special gigapixel panoramic display
Want to see more art?
View the entire National Gallery Collection online


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Human Epilepsy Genetics--Neuronal Migration Disorders Study
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
|Epilepsy Seizures Cognition Disorders Neuronal Migration Disorders
|Study Type:
|Study Design:
|Observational Model: Family-Based
|Official Title:
|Human Epilepsy Genetics--Neuronal Migration Disorders Study
- Identification and characterization of genes important in normal brain development and associated with congenital brain malformations. [ Time Frame: Ongoing ]
Biospecimen Retention: Samples With DNA
|Estimated Enrollment:
|Study Start Date:
|April 1996
|Estimated Study Completion Date:
|February 2019
|Estimated Primary Completion Date:
|February 2019 (Final data collection date for primary outcome measure)
Pediatric epilepsy is responsible for tremendous long-term healthcare costs. Analysis of inherited epilepsy conditions has allowed for identification of several key genes active in the developing brain. Although many genetic abnormalities of the brain are rare and lethal, rapidly advancing knowledge of the structure of the human genome makes it a realistic goal to identify genes responsible for several other epileptic conditions.
The purpose of this study is to identify genes responsible for epilepsy and disorders of human cognition (EDHC). The Walsh Laboratory at the Children's Hospital Boston and Beth Israel Deaconess Medical Center is looking for genes involved in brain development. Conditions that we study include brain malformations, such as polymicrogyria, lissencephaly, Walker-Warburg syndrome, heterotopias, and cerebellar hypoplasia, and inherited disorders of cognition, such as familial mental retardation and familial autism; people with these conditions also often have epilepsy. The structural brain abnormalities are usually diagnosed by brain MRI or sometimes CT scans. Adults and children with these conditions, and their family members, are invited to participate in our study. By comparing the DNA of individuals or families that carry EDHC to the DNA of people in the general population, it may be possible to learn more about the genetic bases of certain forms of EDHC.
Study participants must have a brain malformation or disorder of cognition such as mental retardation or autism in addition to epilepsy in order to take part in this research.
|Ages Eligible for Study:
|Child, Adult, Senior
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
- Males and females of any age.
- Persons with a brain malformation or disorder of cognition (intellectual disability [previously known as mental retardation] or autism).
- Persons without a brain malformation or disorder of cognition (intellectual disability (previously known as mental retardation] or autism).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00041600
|Contact: Brenda Barry, MS
|Contact: Jennifer Partlow, MS
|United States, Massachusetts
|Children's Hospital Boston, CLS15070, Walsh Lab
|Boston, Massachusetts, United States, 02115
|Contact: Brenda Barry, MS 617-919-4371 firstname.lastname@example.com
|Contact: Jennifer Partlow, MS 617-919-2865
|Principal Investigator: Christopher A. Walsh, M.D., Ph.D.
|Children's Hospital Boston; CLS 15070
|Boston, Massachusetts, United States, 02115
|Contact: Brenda Barry, MS 617-919-4371 firstname.lastname@example.com
|Contact: Jennifer Partlow, MS 617-919-2865
|Principal Investigator:
|Christopher A. Walsh, M.D., Ph.D.
|Harvard Institutes of Medicine
Additional Information:
|Responsible Party:
|Dr. Chris Walsh, Investigator, Harvard University Faculty of Medicine
|ClinicalTrials.gov Identifier:
|NCT00041600 History of Changes
|Other Study ID Numbers:
R01NS035129 ( U.S. NIH Grant/Contract )
|Study First Received:
|July 11, 2002
|Last Updated:
|June 27, 2014
Keywords provided by Dr. Chris Walsh, Harvard University Faculty of Medicine:
disorders of human cognition
neuronal migration
neuronal migration disorders
agenesis of the corpus callosum
Additional relevant MeSH terms:
Cognition Disorders
Malformations of Cortical Development, Group II
Pathologic Processes
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Neurocognitive Disorders
Mental Disorders
Malformations of Cortical Development
Nervous System Malformations
Congenital Abnormalities
ClinicalTrials.gov processed this record on September 21, 2017


text: Wallace & Barnes garment-dyed herringbone military pant Item F8619 Size: All sizes are US sizes. Size Charts Quantity: 1 2 3 4 5 6 7 8 9 Prices do not include taxes. Add to Bag Wishlist Add to Bag Add To Wishlist share: size & fit Straight through hip and thigh, with a straight leg. 16 ½" leg opening. Product Details This pant is inspired by traditional fatigue pants worn by the U.S. Marine Corps in the '40s and '50s, with authentic details like patch pockets. The herringbone fabric is also garment-dyed, so it has cool highs and lows of color at the seams that add to its old-school appeal, giving you that "fresh from the Army-Navy store" look and feel without the mothball scent. Cotton. Button fly. Machine wash. Import. Select stores. Item F8619.


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Police are hunting for a hit-and-run driver who left a teenage cyclist badly injured in the road.
The 17-year-old boy had to be treated in hospital for facial, arm and hand injuries after being hit by the car near Yeadon on Monday just after 5pm at the junction of Otley Old Road and Tinshill Road.
Police believe the car was a white or silver Nissan Micra being driven by a woman, and have now appealed for her to turn herself in.
The vehicle, which had been travelling towards Yeadon, turned from Otley Old Road into Tinshill Road and collided with the cyclist.
The driver is then believed to have driven away from the scene down Tinshill Road.
Chief Inspector Fran Naughton, of Leeds District CID, said: "The driver of the vehicle needs to be traced as a matter of urgency."
Anyone with information should contact Outer North West Leeds Neighbourhood Policing Team on 101 or Crimestoppers on 0800 555 111.


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In Doug Kass's column outlining his bearish view of the market, he makes the following statement: "The price charts are a picture of what has happened in the past and don't indicate with precision what will happen in the future."
That is an interesting observation, echoed by many who lean toward a fundamental approach to the market. Obviously, past results are no guarantee of future performance (as they say in advertisements for mutual funds and other financial products), so why use charts at all?
Despite an endless search by market players since the advent of trading, there is no perfect indicator. Nothing can predict the future with any great precision. The best we can hope to do is find something that will provide clues as to how events may play out. Fundamental investors tend to believe that the best indicator of how a stock will act is its past financial results. They extrapolate the future, apply a multiple and then wait for the market to appreciate their wisdom.
People are often very wrong about fundamentals, but because it is based on accounting, spreadsheets, budgets, management and the like, many feel as if they have an edge in these matters.
The technical trader tends to believe that charts are good predicative tools because they tell you what big investors tend to think about the fundamentals. If a stock is going up on big volume, it is because someone with lots of money and good research believes the stock will go higher. The past price action matters because it provides clues to the emotions at work.
I see charts as the best evidence we have as to the market's mood. They are a study in psychology and, while they aren't precise, they do have strong tendencies that give you an edge when you are trading.
Right now, the charts indicate that there is little to worry about, which is exactly what Doug Kass says is so bearish. He doesn't need to dismiss the charts to make his point; they reflect exactly what he says about complacency. My view is that there may be complacency in the market, but it isn't sufficient to produce a top at this time. In my experience, it takes much more than this level of positive action and sentiment to produce an extreme that warrants selling. Doug and I see the same things in the charts, but we interpret them differently.
I'm maintaining a bullish bias until I see something in the charts to change my mind.


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Copyright 2011, CABS for Reflections From the Fence
*( From Son # 2 to his parents. At first it looks a bit worse for wear, but, on second look, it has appeal in it's simplicity, the glue, the young child's handwriting, a simple heart. Nothing says it quite like a young child's art.)
This and that from my world of Family Research, Yorkies, Photography, RV's and Traveling.
More Special Pages From Reflections
- Home
- Heritage Flag & The Family Names
- Friend of Friends
- THE Trip, The Maps
- Disclaim THAT! Beholden to - -
- THE Trip, THE Encore' :: The Maps
- THE Trip, THE Encore' :: The Maps, Part Two
- THE Trip, THE Encore' :: The Maps, Part Three
- 2013 Thankful November
- Families Past :: Pedigree Charts
- Edna May Fenton Stevens Time Line Experiments
- Winter Sojourn 2014/15 :: The Maps
- Reflection's Contibutions to the Worldwide Genealo...
Monday, February 14, 2011
Happy Valentine's Day
6 comments:
- Nolichucky Roots said...
And to you!
- February 14, 2011 at 7:33 AM
- IrishEyesJG said...
So sweet, a wonderful heirloom. Wishing you and yours lots of love this day! Cheers, Jennifer
- February 14, 2011 at 9:16 AM
- Joan said...
The best kind of valentine! I too treasure the hand made valentines from my children and grandchildren.
- February 14, 2011 at 9:26 AM
- Kristin said...
I like the tattered heart. Nice valentine.
- February 14, 2011 at 11:12 AM
- Ron and Thelma said...
Happy Valentines day to you and Al Hope he takes you out
- February 14, 2011 at 2:09 PM
- Linda Gartz said...
So sweet! I treasured these little hand-made gifts and thank you for your nice comment on my 1911 Valentine!
- February 14, 2011 at 5:26 PM
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