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- Last 5 years (2)
- Last 10 years (8)
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Journals and Conferences
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- Seth C. Kalichman, Leickness C. Simbayi, +8 authors Moira O. Kalichman
- Prevention Science
- 2009
South Africa is in the midst of one of the world's most devastating HIV/AIDS epidemics and there is a well-documented association between violence against women and HIV transmission. Interventions that target men and integrate HIV prevention with gender-based violence prevention may demonstrate synergistic effects. A quasi-experimental field intervention… (More)
- Mary Crawford, Danielle Popp
- Journal of sex research
- 2003
A review of 30 studies published since 1980 found evidence for the continued existence of sexual double standards: different standards of sexual permissiveness for women and men. Experimental studies have included predominantly White North American college students; ethnographies, focus group and interview studies, and linguistic analyses have included more… (More)
- Kristina B Metzger, A Hajat, M Crawford, F Mostashari
- MMWR supplements
- 2004
INTRODUCTION Syndromic surveillance monitors trends in nonspecific health indicator data to detect disease outbreaks in a timely manner; however, only a limited percentage of persons with mild illness might exhibit behaviors that could be detected by syndromic surveillance. OBJECTIVES The objectives of this study were to 1) examine the demographic… (More)
- Clarke E Atkins, Bruce W Keene, +13 authors Justin H Straus
- Journal of the American Veterinary Medical…
- 2007
OBJECTIVE To determine the efficacy of long-term enalapril administration in delaying the onset of congestive heart failure (CHF). DESIGN Placebo-controlled, double-blind, multicenter, randomized trial. ANIMALS 124 dogs with compensated mitral valve regurgitation (MR). PROCEDURES Dogs randomly assigned to receive enalapril or placebo were monitored… (More)
- Annie Beth Fox, Jonathan Rosen, Mary Crawford
- Cyberpsy., Behavior, and Soc. Networking
- 2009
Instant messaging (IM) has become one of the most popular forms of computer-mediated communication (CMC) and is especially prevalent on college campuses. Previous research suggests that IM users often multitask while conversing online. To date, no one has yet examined the cognitive effect of concurrent IM use. Participants in the present study (N = 69)… (More)
- M A Crawford, W D Schall, R K Jensen, J B Tasker
- Journal of the American Veterinary Medical…
- 1985
Chronic active hepatitis with increased hepatic copper concentration was diagnosed in 25 female and 1 male Doberman Pinscher dogs. Common clinical signs included polyuria/polydipsia, weight loss, anorexia, icterus, and ascites. Increased liver enzyme activities and abnormal liver function test results were the most consistent clinicopathologic changes. The… (More)
- Michelle R Kaufman, Tamara Shefer, Mary Crawford, Leickness C Simbayi, Seth C Kalichman
- AIDS care
- 2008
The Gender Attitudes-Power-Risk (GAPR) model of HIV risk behavior was tested using survey data collected from among 309 men who were attending STI services in a primary health care clinic in Cape Town, South Africa. Results showed that negative attitudes towards women were significantly positively associated with a high level of HIV risk behavior, and that… (More)
- Mary Crawford, Michelle R Kaufman
- Violence against women
- 2008
There has been little systematic research on therapy, rehabilitation, and social reintegration of women formerly trafficked into prostitution. This study examines characteristics and outcomes of Nepali sex trafficking survivors. Twenty case files of survivors rehabilitated in the shelter of an antitrafficking NGO were randomly selected. All individuals in… (More)
- Clarke E Atkins, William A Brown, +13 authors Justin Straus
- Journal of the American Veterinary Medical…
- 2002
OBJECTIVE To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation. DESIGN Randomized controlled trial. ANIMALS 139 dogs with mitral regurgitation but without overt signs of heart failure. PROCEDURE Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23… (More)
- Michelle R Kaufman, Mary Crawford
- Violence against women
- 2011
Trafficking of girls and women for the purpose of sexual exploitation is a problem worldwide, particularly in South Asia. This review focuses on Nepal-to-India sex trafficking with an examination of current anti-trafficking intervention and prevention programs. The activities of both governmental agencies and nongovernment organizations are described and… (More)


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MSc Chen
Electronic Instrumentation (EI), Department of Microelectronics
Promotor: Michiel Pertijs
Expertise: ASICs for medical ultrasound and data converters
Chen Chao was born on 11 December, 1987 in Longhai, Fujian province of China. He received B.Sc degree in 2010 from Tsinghua University, Beijing, China and M.Sc degree in 2012 from Delft Universitiy of Technology, both in microelectronics. For his M.Sc thesis, he worked on energy-efficient self-timed incremental ΔΣ ADCs. Since December 2012, he has been a Ph.D candidate in the Electronic Instrumentation Laboratory at TU Delft, where he works on ASIC design for medical ultrasound. He was awarded the Toptalent scholarship by TU Delft and the HSP scholarship by the Dutch government for his M.Sc study, and the 2013 Student Travel Grant Award (STGA) by the IEEE Solid-State Circuits Society.
Last updated: 11 Aug 2017

subset: commoncrawl


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Video | Update Your Handbag for Spring
We are having a hard time choosing our favorite trend from the top 5 latest handbag styles for spring! The great news is that there is a variety of fun new looks and if one doesn't suit your style, another one surely will. We are seeing the soon-to-be-iconic bucket bag on the arms of fashionistas everywhere and it's destined to be a classic. The boho and '70s-inspired bags with their tassels, fringes and vintage leather are on our must-have list for the weekend. Mini bags are perfect for luncheons, events and nights out (just make sure your phone fits!). And everyone needs a beautiful tote bag, whether it's for work, yoga or vacation.
Today on NBC Channel 12's Arizona Midday, MSL's Angela Keller shows us the top 5 trends and what's haute this spring.
For details or questions regarding any of the items featured in the segment, please email firstname.lastname@example.com or comment below.
1 | Bucket | Vince Camuto Black & White Bucket Bag // MICHAEL Michael Kors Denim Bucket Bag
2 | Boho | Frye Slouchy Fringe Bag // MICHAEL Michael Kors White Fringe Bag
3 | The '70s | Patricia Nash Saddle Bag
4 | Mini | ZAC Zac Posen Blue Mini Bag (similar here) // Antonio Melani Snake-Embossed Bag (similar here)
5 | Chic Tote | Botkier Python Color-Block Tote // Furla Orange Tote
(Editorial Note: All handbags featured above and on the show are from Dillard's at Scottsdale Fashion Square.)
One response to "Video | Update Your Handbag for Spring"
For an everyday bag that still looks fun, I like labellacouture.com. Great quality, lots of room & individual style!
Leave a Reply
These Little Red Dresses Have Our Heart
Fab Finds | Summer Bag Craving
Beauty Secrets from Scottsdale Fashion Week Revealed!
Video | Shop On-Trend Fall Handbags
Cool Tech Gifts for Dad
Fab from the Lab | Discovered Weekly
Gold Medal USA Style for the Win
Celebrate in Emerald Isle Style
What to Wear for Super Bowl Parties
At Work | Workworthy Chambray


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Hiring for Content Writers in Hyderabad / Secunderabad, for Exp. 2 - 3 yrs at First Show Digital - Startup.
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Job Description:Recreate the brief as given by Digital Media Managers Be extensively verbose and have an irrational thirst for words Interact with design and strategy team for unhindered flow of ideas Write content best fitting the strategy and design
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Dakota Blue Richards - London Fashion Week Spring/Summer 2016 - Sorapol - Front Row and Inside at The Royal College of Surgeons, Lincolns Inn Fields, London Fashion Week - London, United Kingdom - Saturday 19th September 2015 (1 Picture)
Dakota Blue Richards
Photo credit: Phil Lewis
View All: London Fashion Week Spring/Summer 2016 - Sorapol - Front Row and Inside
Next Dakota Blue Richards Slideshow: The European Premiere of Marvel's: "Ant-Man" - London United Kingdom - Wednesday 8th July 2015
Many ticket-holders couldn't get into the O2 Arena show on Tuesday night (September 19th) because they didn't bring photo ID to match their booking.
An album re-release, a new song and a documentary mark the singer's legacy this year.
The film will be the first in the Marvel Cinematic Universe led by a person of colour.
The actor plays the titular hero in the forthcoming adaptation.
Watch the trailer for Secret Of Moonacre.Maria Merriweather is a young girl who lives with...
That New Line Cinema did so well with the Lord of the Rings trilogy is...


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Chili Chocolate Short Ribs with Cheddar Polenta
By Donnell Collin's of Leunig's Bistro
Chili Rub:
2, 8-10 oz. beef or veal short ribs
2 Dried ancho chilies
1 tablespoon brown sugar
1 1/2 tablespoons cocoa powder
1 tablespoon chopped fresh thyme
Toast chilies 8-10 minutes. Buzz in food processor until powder. Place in bowl and add remaining ingredients and mix well. Coat the short ribs very well and let sit overnight.
1 cup Spanish onion chopped
¼ cup chopped garlic
2 ribs of celery, chopped
1 large carrot, chopped
Preheat oven to 375. Place two tablespoons of oil In an oven-proof pot. Sear the short ribs on all sides, about 6-8 minutes. Remove short ribs and set aside. To the same pot, add all the above chopped vegetables [mirepoix] and sauté about 4 minutes.
2 1/2 cups red wine
2 tablespoons butter
2 cups chicken, beef, or veal stock
Add wine, butter, and stock to the pot. Bring to a simmer, scraping all the browned goodness off the bottom of the pot [deglazing]. Return the short ribs and bring to a boil. Cover and transfer to the oven. Braise until meat is very tender and almost falling off the bone, about 1 1/2 hours.
Using a slotted spoon, transfer the ribs to a plate and cover to keep warm. Skim the fat from the top of the braising liquid. Simmer the liquid 'till it thickens slightly, about 20 minutes. If needed, thicken with 1 tablespoon butter and 1 tablespoon flour, mixed in well with a whisk. Let simmer until thickened.
Cover ribs with sauce and serve with Cheddar Polenta:
Creamy Cheddar Polenta
2 ½ cups chicken stock
¼ cup heavy cream
2 tablespoons butter,
¾ cup polenta
½ cup grated sharp cheddar
Bring stock, heavy cream and butter to a boil. Gradually add the polenta, whisking constantly. Bring to a boil; then reduce heat to a simmer. Cover, but continue to stir frequently, and simmer until the polenta is tender, about 8 minutes. Remove from heat, stir in cheddar, and season with salt and pepper.
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User Reviews for Mirena
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Mirena.
|Avg. Ratings
|Birth Control
|1380 reviews
|300 medications
|Abnormal Uterine Bleeding
|337 reviews
|109 medications
|Summary of Mirena reviews
|1717 reviews
Reviews for Mirena
For Abnormal Uterine Bleeding "OMG! I'm scheduled to have an IUD inserted in 2 weeks. I'm having second thoughts after reading all of your experiences w/ it. I'm 48 and have constant bleeding, anywhere from very light & only when I wipe to very heavy w/ clots. My doctor swears this will help w/ the constant bleeding. I almost wish he'd just do a hysterectomy."
Chris2299 September 19, 2017
0 users found this comment helpful.
For Abnormal Uterine Bleeding "I had the mirena placed in April of 2015. I have had long, irregular periods ever since I got it. At first I just dealt with the bleeding because I felt better than being on the pill, but things quickly changed in May of this year. From May 2015 to January of 2017 my periods were: The first was 8 weeks, 2nd was 6 weeks, periods 3 -7 were 3 weeks long. Then in May of 2017 I started having MONTHLY 3+week periods with a few days of breast tenderness then it starts back up. I have had two ovarian cysts with it. I have extreme breast tenderness a few days before the start of every period. I have zero sex drive. This does nothing for my skin and I have issues with hidradenitis. I have very low energy levels. I am just ready to have it removed"
Veryunhappyliz (taken for 2 to 5 years) September 18, 2017
0 users found this comment helpful.
For Abnormal Uterine Bleeding "I had been on the pill since I was 14yrs old for excruciating period cramps along with extremely heavy bleeding (I could go through a super plus tampon in 20min!) Now, at 23, on May 9th I had the Mirena inserted. The procedure was extremely painful to the point that I felt like I was going to pass out, my hands were clammy, and I had a death grip on the sides on the exam table. (I don't have any kids). To date, I have gained 30 pounds and nothing I have done to lose it has worked. I've lost 40+ pounds twice in my life, so I know how to lose it. I'm also tired ALL the time. I can literally nap at any point in the day. And I have painful ovarian cysts (which I knew was a side effect prior). Seriously considering taking it out."
Ashr22 (taken for 1 to 6 months) September 17, 2017
0 users found this comment helpful.
For Abnormal Uterine Bleeding "Ugh I wish I had found these reviews before I had it I'm so angry I had it because I was having two week periods heavy each month .. I've now had this six weeks haven't stopped bleeding once I'm cramping badly gained 10 pounds tired all the time irritable skin looks horrible with acne and no end to the bleeding it's horrible my sex drive is gone and I'm usually very sexual After reading this I am not sure I want to keep it in because dr keeps saying give it time but most people here say even after six months it's the same so I've swapped a bad problem for a much worse one! Ugh so frustrated I'm 46 so they won't give me the pill so this seemed the next best choice! I wish the dr could be more honest or informed about so many people having"
Sonnjazzy September 16, 2017
0 users found this comment helpful.
For Abnormal Uterine Bleeding "Soon to be 51 and had the mirena inserted 7 years ago for endometrial hyperplasia. My Dr (whom I love) said it would likely make my periods stop (hurray) and would protect my uterus. Well it DID NOT make my periods stop - and it took well over two years for me to start feeling "normal". I have had pH issues and flares of Bacterial Vaginosis ever since. I've tried everything on the market for it only to be told by my Dr to "use Luvena" every time I brought it up during my annual. Anyway, I stuck it out the entire seven years and am due to have it removed in a few weeks. I honestly cannot wait. I've always been very sensitive to progesterone- too much makes me feel like a depressed lead balloon."
Boterosmom (taken for 5 to 10 years) September 14, 2017
0 users found this comment helpful.
For Abnormal Uterine Bleeding "I have suffered from incredibly heavy periods since having my two kids (I'm 38). After having the Mirena inserted (which hurt, but was quick and no worse than a labour pain) I spotted for approx 3 months. During this time, I also experienced some depression, drop in sex drive (which my dr. insisted is not related), breast tenderness and subtle weight gain. Its now been 5 months. I've decided to have it removed. The spotting has stopped, aside from after sex-not so sexy; I am having fairly regular cramping which I can only liken to the feeling of an ovarian cyst. I've never carried weight around my middle; I'm a very active runner with a healthy diet but I swear this thing has given me a very doughy tummy. I just want it gone."
jesterina (taken for 1 to 6 months) September 8, 2017
2 users found this comment helpful.
For Birth Control "I've had the mirena IUD for 5 months now and so far I've loved it!! I haven't had any weight gain or acne symptoms that everyone talks about in their reviews. I bled for maybe three days after the procedure and haven't had a period since. The procedure sucks but its bearable. It felt like intense cramping for maybe a minute then it's over. I suggest taking 800mg of ibuprofen before and after because I did have cramps and dizziness for the whole day. I switched to mirena from oral BC because oral BC made me absolutely crazy (crying at every little thing, irrational, emotional, blowing up at people for no reason, ect) ladies DON'T LET THE REVIEWS SCARE YOU because every body reacts differently.. you truly have to try it out for yourself!!"
Sami Jo (taken for 1 to 6 months) September 7, 2017
3 users found this comment helpful.
For Birth Control "I had hair loss and lack of appetite when I had Mirena. I always felt sick. When I got it out I had delayed return of fertility for 3.5 years."
Heybaby458 (taken for 2 to 5 years) September 6, 2017
0 users found this comment helpful.
For Birth Control "My Mirena caused severe cramping 4 days a week, an inflamed cervix, and caused weight gain. Doc kept saying I was just adjusting. After 1.5 years I got it out and feel so much better. Seriously consider how this can affect your health."
Notforme September 6, 2017
0 users found this comment helpful.
For Abnormal Uterine Bleeding "Had mirena inserted March 2016 and had a horrible month of cramps and bleeding. Things subsided for a couple of months but now I have heavy bleeding 2-3 weeks a month. Even though it is just coming up on 6 months I emotionally don't know how much longer I can take this and it is wrecking my intimacy with my fiancé. My Periods much worse and much less predictable than before :("
CMSB September 2, 2017
4 users found this comment helpful.
For Birth Control "I was really excited for Mirena because I suffer from seveer cramps and a very heavy period. This definitely helps that. But my period was irregular, showed up for 2 weeks at a time sometimes, every other week, after sex....there was no rhyme or reason and incredibly annoying. I also had other symptoms that I did not link to Mirena initially until I started doing research and it all made sense. Depression and anger slowly crept in. I chalked it up to being exhausted all the time (another symptom) and not having patience now that I had 2 kids instead of 1. Terrible mood swings. I gained 30 pounds. I always had acne on my chin. My hair thinned terribly. Again, I thought these were from having another baby, but 2 1/2 years later & its the same"
Lyn31 September 1, 2017
0 users found this comment helpful.
For Birth Control "Yes, it was quite painful to insert even with two Tyleno-3 tablets and a numbing gel, however totally worth it as birth control. But... I've gained 60 pounds in 8 months! I'm eating very clean - no sugar, no junk food, barely any carbs and I'm a heifer now!!! Going to my gynecologist tomorrow and getting it removed, I can't deal with this anymore!"
SmithandCult August 31, 2017
3 users found this comment helpful.
For Birth Control "DON'T GET THE MIRENA IUD. I wanted to love the Mirena, I really did. I'm 23, no kids & wanted a low maintaince birth control. Insertion & initial cramping were pretty bad but thats normal. I liked my IUD for the first year or so. Didn't gain weight like I did on the pill & no real side effects. But my love for the IUD turned to hatred when I discovered it had given me an OVARIAN CYST. I started having an excruciating pain deep in my abdomen. The pain was right next to my hip bone and was unlike ANY pain I've ever had. It would radiate down my leg & up my back. Some days I couldn't even stand up or go to work. Finally got an ultrasound and discovered it was a cyst so now its out and I feel SO much better. Please don't get the Mirena!!"
lizzlee56 (taken for 2 to 5 years) August 31, 2017
1 users found this comment helpful.
For Birth Control "My mirena was inserted less than a month ago. The side effects were okay initially with the cramping. I did have spasms in my rectal area. I had a follow up to check for the strings and the strings could not be found. An ultrasound was completed and the IUD was found out of place. I had to get an x-ray as well to confirm the position. Now I have to have outpatient surgery to get it removed. I hoped that I wouldn't have to go through this. But I guess that I may have been at a higher risk since I'm nursing. I will not use this again."
Elaine C (taken for less than 1 month) August 31, 2017
1 users found this comment helpful.
For Birth Control "I used to suffer from extremely heavy periods and cramping that interfered with my daily life. I would have to take time off work, rearrange my entire schedule and in general have an awful time with PMS before my period. Since getting my Mirena, I have had NONE of those symptoms. I finally can live my life without worry that my period will interrupt it. I do not get a period and I do not have any PMS symptoms. It's clear to me that Mirena changed my life for the better."
valhallasdoor August 28, 2017
3 users found this comment helpful.
For Birth Control "After having my first child, I decided to try a long-term method of birth control. I was open to the IUD but very scared about the insertion. I went to planned parenthood and loved their customer service. They gave me pain medicine before insertion which I was VERY happy about! I felt only a little pressure when the nurse inserted it and no pain at all afterwards. It has now been almost 5 months since the insertion and I have yet to get a period. Do not know what to expect but am so far very pleased with my decision! Would definitely recommend! STOP reading reviews! I did and I got super scared and almost didn't go through with it. Every body is different but recommend you carry pain meds w you if worried about pain during procedure"
Karina, 18 (taken for 1 to 6 months) August 27, 2017
6 users found this comment helpful.
For Birth Control "I had my Mirena in for only a month- I seemed to be adjusting fine with normal spotting 3 weeks after, cramping only the first 42 hours it was in (until my next period came) BUT I happened to go to the eye Dr. Where they diagnosed me with early stages of papilledimia, or swelling of the optic nerves due to excess cerebral spinal fluid built up in my brain. I have been experiencing all of the symptoms of a large brain tumor, while slowing going blind for the last month. I now need to see a brain specialist to make sure I'm not continuing to be effected even though I got the IUD removed- when caught early, the damage can be reversible. My Dr. Was not aware of this as a possible side effect."
Mrs Ray (taken for less than 1 month) August 27, 2017
0 users found this comment helpful.
For Birth Control "I am on my second Mirena. I had my first one fitted at my Post partum check up in 2007. I had it for 6 years. That's right, a year over the recommended and approved time frame. The first time insertion was not painful. Periods stopped after a year. When I had it removed, my doctor at the time refused to give me another one (different doctor than the one who inserted the first) and instead talked me into the Depo shot. After a miscarriage and extremely heavy periods and a doctor change I just had another Mirena placed a week ago. Insertion wasn't painful, just uncomfortable. I had no bleeding or spotting. Absolutely none. I cramped a little the first day, but none since. The Mirena isn't for everyone, but it has been a life saver for me!"
Eureka D August 23, 2017
5 users found this comment helpful.
For Birth Control "Insertion was incredibly painful even with meds before hand. But it was quick. I have PCOS, I'm 41 and have been off balance hormonally and now I am feeling pretty great after a week with these hormones balancing me out. As for me, cramping, bloating and back pain are still there, although not as strong. Cervix is still a little raw but nothing some Motrin can't alleviate."
TRCS August 22, 2017
1 users found this comment helpful.
For Birth Control "Mirena has been the best birth control I've tried and I've tried them all! Yes insertion was painful and I did have a decently long time (about 3 months) where I would spot or bleed but after having it for 4 years now, I can honestly say it's so worth it. I have had no weight or mood changes, period completely stopped after the three month bleeding and ever since I've nearly forgot about it. My skin has always been oily so I can't blame it for that and I haven't experienced cramping, my ex said he could feel it but I think it was just because I had it inserted partway into our relationship and he was paranoid because my current boyfriend says he doesn't notice anything abnormal. I can't wait to get my new one!"
Klineb (taken for 2 to 5 years) August 22, 2017
2 users found this comment helpful.
For Abnormal Uterine Bleeding "I have had the mirena for about 1 and 1/2 years now. I bleed more days than not. I have weird pains I have never had until this was inserted. My hip hurts during ovulation and during my cycle. My bleeding is down to a light tampon amount which is a big change. I could go thru a super plus sometimes in 20 minutes. Overall it has helped make it lighter but it lasts a lot longer. Not sure if it is worth it or just find out the reason your periods are so out of control."
Anonymous (taken for 1 to 2 years) August 21, 2017
2 users found this comment helpful.
For Birth Control "I am 18 and have never gave birth and was previously on the pill. I got mirena almost a month ago. My gynecologist gave me misoprostol to take 3 hours before the procedure and 600 mg of ibuprofen. The insertion was extremely painful for me, but the procedure only took about 10 minutes. After the procedure I had some cramping and a brown discharge for the rest of the day. The next day I woke up and felt great. Ever since I have not had any problems except for some bleeding the first 2 weeks which is normal and easily controlled by using a light pad. The insertion was very painful, but SO worth not worrying and about getting pregnant and taking the pill perfectly. If you can take a day of pain I recommend this full heartily. Mirena is awesome"
Anonymous (taken for less than 1 month) August 18, 2017
2 users found this comment helpful.
For Abnormal Uterine Bleeding "I was so desperate to put an end to months of heavy and almost non-stop bleeding (I'm 54) that I had a Mirena inserted. It did stop the continuous heavy bleeding but now I have light continuous bleeding and have gained over 10 kg in weight, and am ALWAYS tired. I am having mine removed this afternoon and can't wait. If the heavy bleeding returns I'll deal with it some other way."
Wendy Mc August 18, 2017
3 users found this comment helpful.
For Birth Control "Spectulum was hugely painful, one of the worst pains I have ever felt to be honest. Insertion was not comparable to that for me but was quite uncomfortable. So far bleeding was for the first two days only, no cramps, no discomfort. A lot of checking there to figure out whether there was too much or too little wire sticking out so that has been a frightening thing. Breasts hurt like anything but so far definitely worth it!"
Anonymous (taken for less than 1 month) August 16, 2017
2 users found this comment helpful.
For Birth Control "This is my 3rd device & I have had the mirena for over 13years. On my 3rd insert my gynaecologist asked if I have been depressed and I said yes thinking it was because I was working full time single mum and was tired. I finally had counselling and felt good again but after a few weeks I was drained. However during these years, I was deeply depressed and severe anxiety issues, on medication and after speaking to my female doctor we worked out it was the bloody MIRENA, all those years of feeling awful. Use Condoms instead, trust me it's not worth it. I am 41 & love being myself again."
Sparkles014568 August 16, 2017
2 users found this comment helpful.
Learn more about
Micromedex® Care Notes
Symptom checker
Symptoms and treatments
More about Mirena (levonorgestrel)
- Side Effects
- During Pregnancy
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- Drug Interactions
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- Support Group
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- En Español
- 1746 Reviews – Add your own review/rating
- Drug class: contraceptives
Consumer resources
Other brands: Skyla, Plan B, Kyleena, Plan B One-Step, ... +10 more


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Buy HULTAFORS HULTS16 CLAW HAMMER 16OZ 720G at Anglia Tool Centre for £22.96 Not found the cheapest price for Hultafors Tools Hammers your looking for?
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After four years of living content and at peace, Camila Cabello is forced to move back to her hometown of Miami, Florida, where she left nothing behind other than bullies and a crush that didn't exactly work out. When she starts her new school, she has plans to fly under the radar, but everything changes when she comes into contact with a group of girls, one of which she has a terrible history with.
chanchololo Aug 21
Normani is fücking gorgeous and I will continue saying that until I die
EscapeRoute4 Jul 26
Did y'all see the interview where they asked the girls about Camila and all the other girls brushed it off but Dinah didn't say anything and she looked distraught, OMG MY CAMINAH HEART
Camson_15 Jun 28
They better be giving some gas money for taking them everyday lol
mature_enough 4 days ago
mature_enough 4 days ago
MY SUNSHINE!!! OMG. ALLY IS SO CUTE! Like seriously! I love her!!! 😍
Thirteenreasons01 Aug 02
I prefer my elective classes, French, Spanish, Drama, Music and Theatre


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Video from How to Dad/YoutubeHow to Dad is slowly becoming one of our favorite channels on YouTube. You may remember it for the hilarious tutorial videos on how to hold a baby and how to feed a baby.His new video, How to Travel with a Baby, is filled with nuggets of wisdom, starting with the first rule, "Don't lose the baby," while the baby can be seen wandering off shot. He also demonstrates several techniques on how to explore a chosen vacation spot on foot while with a baby. Our favorites include "The Running Dad" (we think you have a clear idea what this is about), "The D.I.Y." (basically the no-hands approach) and "The Over Protective Dad" (very familair to all, which involves frantically finding a safe spot while holding the baby to your chest to protect him from the cruel outside world). Which one of these have you done while on holiday?
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Adventure Valley
County Durham
Tel: +44 0191 386 8291
Discover a world of family adventures at Adventure Valley, the North East's biggest family adventure park.
With over 40 attractions, activities and shows and three huge indoor play and animal zones, whatever the weather Adventure Valley has it covered.
Outdoor Adventures: Explore the Action Creek and Runaway Ranch. Bounce high on the jumping pillows, race friends on the go karts, whoosh down the slide stampede, explore one of the UK's biggest play forts, pan for gold or try to get a hole in one on the 18hole Adventure Golf Course.
Animal Encounters: Meet the cutest and friendliest of animals in the indoor farmyard and in the paddocks, plus daily scheduled animal activities including pony grooming, rabbit cuddling and more. On weekends and school holidays watch the fabulous Bird-o-Batics flying shows.
Indoor Play@ All weather fun is assured in the 2 huge indoor play zones. Climb, scramble and zoom down the slides in the giant 3 storey play town. Go wild in the Wild West themed soft play area including the Cannon Saloon shoot out.
And to ensure everyone can play there's Little Play for the under 5s too.
Guide Prices
|Ticket Type
|Ticket Tariff
|Child and adult prices (off peak)
|£6.95 per ticket type
|Child and adult prices (Weekends and School Holidays)
|£9.75 per ticket type
|Over 60s (off peak)
|£5.95 per ticket type
|Over 60s (weekends and school holidays)
|£8.75 per ticket type
Off peak is term time Mon-Fri. Mid season: adults and children, £8.95, over 60's, £7.95. Children under 2 free.
- Visit England Quality Assured Visitor Attraction 2017
- Certificate of Excellence 2017
TripAdvisor Traveller Rating:
- Excellent371
- Very Good204
- Average81
- Poor34
- Terrible46
Recent Reviews:
- Laura DDurham, England, United KingdomTrip Type:FamilyGreat facilitiesSaturday, 9th September 2017Great facilities. Love the new under 5s soft play area and makes it more worthwhile visiting. Lots of animals. Have an annual pass Read full review
- TheTraveller044Durham, United KingdomTrip Type:FamilyGreat family day outThursday, 7th September 2017Came to Adventure Valley as a day out for our daughters birthday. She loves the place and we think it's not badly priced for a full day out. There's plenty for all the kids to do and the newly opened... Read full review
- MotherlandNorth East EnglandTrip Type:FamilyGreat day outWednesday, 6th September 2017Visited at the end of the 6 weeks holiday and caught some great weather. Book in advance on line for best prices. Plenty to do inside and outside and good value. Nice cafe for food and drink and... Read full review
Parking & Transport
- On site parking
Access Information
Opening Times
|2017 (1 Jan 2017 - 31 Dec 2017)
|Monday - Sunday
|- 17:00
|Bank Holiday
|- 17:00
* We recommend allowing at least 2.5 hours to enjoy the facilities.
Map & Directions
Road Directions


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L'ospite del giorno: Marianna D'Ezio, traduttrice di Jane Eyre - Siamo state felicissime di poter intervistare per il nostro blog Marianna D'Ezio, traduttrice di Jane Eyre per Giunti editore (2011) ma anche docente unive...
1 day ago
Fires I Would Like To Know
Hannah Johnson
Published: March 09, 2012
Words: 6,810 (approximate)
'He tells me, like a regular Bluebeard, never to visit the third floor.' What if Jane Eyre had found another source of fascination at Thornfield Hall?
Gothic West
by Jill Morrison
Published by J Z Morrison Press
Published: April 13, 2013
Words: 40,780 (approximate)
Two novellas of love and obsession: In the Shade of Horses A reclusive artist, her nurse and her two sons struggle to keep their secrets. Lightspeed In a twist of Charlotte Brontë's Jane Eyre, a male tutor comes to ruined Las Vegas to encounter, and fall in love with, his female employer.
In the early days of a very close future, Owen Bland is on his way to Vegas, a place inhabited by the obscenely wealthy and the obscenely poor. He has taken a job as a tutor, escaping his savage boarding school life. His employer, Evelyn Sales, is beautiful, rich and brilliant. As Bland comes to love this complicated woman, he finds himself drawn into the terrible secret she cannot leave behind.


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Make your home beautiful with Gardens by TWIG. Twig has decorated Roots Cafe inside and out with their one-of-a-kind pieces. Each handmade piece is for sale so if you are interested please ask your server....Learn More
Some exciting news at the Roots Café…We are coming out next week with a new DINNER menu and the breakfast and lunch menus have been a big hit!Learn More
At Roots Cafe, our mission is to provide locally grown ingredients for West Chester Locals!Learn More
So its getting close to Spring, and for me and a lot of others that means GARDENS!Learn More
We will be starting our own Fresh Organic Locally Grown Produce Market out back of Roots Café from 8am-4p every SundayLearn More
We at Roots Cafe will continue to fight and support diversity within our staff and our amongst our guests. Our Cafe is a place where all are welcome and should feel safeLearn More


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Production of a vast antibody repertoire is essential for protection against pathogens. Variable region germline complexity contributes to repertoire diversity and is a standard feature of mammalian immunoglobulin loci, but functional V region genes are limited in swine. For example, the porcine lambda light chain locus is composed of 23 variable (V) genes and 4 joining (J) genes, but only 10 or 11 V and 2 J genes are functional. Allelic variation in V and J may increase overall diversity within a population, yet lead to repertoire holes in individuals lacking key alleles. Previous studies focused on heavy chain genetic variation, thus light chain allelic diversity is not known. We characterized allelic variation of the porcine immunoglobulin lambda variable (IGLV) region genes. All intact IGLV genes in 81 pigs were amplified, sequenced, and analyzed to determine their allelic variation and functionality. We observed mutational variation across the entire length of the IGLV genes, in both framework and complementarity determining regions (CDRs). Three recombination hotspots were also identified, suggesting that non-allelic homologous recombination is an evolutionarily alternative mechanism for generating germline antibody diversity. Functional alleles were greatest in the most highly expressed families, IGLV3 and IGLV8. At the population level, allelic variation appears to help maintain the potential for broad antibody repertoire diversity in spite of reduced gene segment choices and limited germline sequence modification. The trade-off may be a reduction in repertoire diversity within individuals that could result in increased variation in immunity to infectious disease and response to vaccination.
A diverse antibody repertoire is critical for producing specific antibodies against a massively wide range of pathogens and establishing effective immunity (Baumgarth et al. 2005; Maizels 2005; Ohlin and Zouali 2003). While the porcine immunoglobulin heavy chain and lambda and kappa light chain loci have been described, only the lambda locus is completely characterized (Schwartz et al. 2012a; Schwartz et al. 2012b; Yerle et al. 1997). Within the porcine lambda locus, there are a total of 23 variable (IGLV) genes, 4 joining (IGLJ) genes, and 3 constant region (IGLC) genes. Of these, more than half of the IGLV genes are pseudogenes, and only two IGLJ and two IGLC genes are functional (Schwartz et al. 2012b). The apparent lack of diversity between the two nearly identical functional IGLJ genes limits combinatorial diversity. Also, terminal deoxynucleotidyl transferase (TdT) activity is below detectable levels in B cells undergoing light chain rearrangement, further reducing light chain junctional diversity (Wertz et al. 2013). To compensate for these deficiencies, we hypothesize that there is a substantial amount of allelic variation amongst IGLV genes at the population level, thus providing broad population immunity under conditions of increased individual immune risk. Allelic variation in the lambda locus is significant since approximately 50% of porcine immunoglobulins contain lambda light chains (Butler et al. 2005).
Studies of the porcine immunoglobulin repertoire have been limited at the individual haplotype level and little is known about the germline variation of light chain genes at the population level, which is critical for understanding the genetic basis of herd immunity. The previous characterization of the porcine lambda locus was in one adult Duroc and inferred from 239 fetal and neonatal lambda mRNA sequences (Wertz et al. 2013). Using a high-throughput sequencing approach, we found substantial allelic variation in IGLV genes among 81 pigs. All but two genes previously defined as functional were found to possess non-functional variants, while none of the previously defined pseudogenes possessed functional copies.
Spleen tissues from 78 pigs and bronchial lymph node tissues from 3 pigs were obtained from a genetically uniform, cross-bred commercial source herd leveraged from a previous study (Klinge et al. 2009) (see Supplemental Table 1 for sample collection and treatment information). Tissues were homogenized using a rotor-stator homogenizer and genomic DNA was purified using the DNeasy Blood & Tissue Kit (Qiagen). Quality and concentration of all genomic DNA samples was determined by gel electrophoresis and absorbance at 260 nm (Nanodrop Technologies), respectively.
Primers specific for entire IGLV gene families or individual genes were designed with Primer-BLAST and used to amplify IGLV gene segments in 12 individual PCR reactions for each of 81 animals as detailed in Supplemental Table 2 (Ye et al. 2012). Amplification primers were targeted to 5' intron, 5' framework and 3' intergenic regions to solely amplify unrearranged V genes. Of the 22 known IGLV genes, IGLV1-12 is missing the V-exon and was excluded from analysis (Schwartz et al. 2012b). SYBR Green real-time quantitative PCR was performed using the Stratagene Mx3000p and Stratagene Mx3005p platforms. The temperature profile was denaturation at 95°C for 1 min, followed by 40 cycles of 95°C (4 s) and 60°C (40 s), then 95°C (1 min), 70°C (30 s) and 88°C (30 s). The specificity of the 972 PCR products was confirmed by melting temperature analysis and, in some cases, but gel electrophoresis. Failed reactions were repeated. PCR products were purified using the QIAquick PCR Purification kit (Qiagen).
Purified PCR products were pooled and submitted to the University of Minnesota Genomics Center for paired-end (250bp × 250bp) sequencing using Illumina MiSeq. Approximately 6 million reads were generated, with 91% of reads having quality scores above 30. Overlapping paired-end reads were merged by Fast Length Adjustment of Short Reads (FLASh) (Magoc and Salzberg 2011), resulting in 75.17% successfully combined reads. Allele identification was performed using BLAST and CD-HIT (Altschul et al. 1990; Li and Godzik 2006). After trimming all of the reads to the V region, there were 275,453 unique sequences in total. Fig. 1 shows the quality filtering process used to identify and differentiate true alleles from artifacts. Briefly, filtered alleles were analyzed by Geneious 6.1 software after removal of singletons and doubletons (Kearse et al. 2012), based on the annotation of Schwartz et al (Schwartz et al. 2012b) and, with minor exceptions, alleles with a frequency <0.6% (1/162, the theoretically minimum allele frequency) were excluded. Translated amino acid sequences were aligned within each gene cluster to confirm predicted translational fidelity. Alleles with a frameshift and/or a premature stop codon were categorized as non-functional. Alleles with synonymous mutations were categorized as silent alleles and those with nonsynonymous mutations were categorized as functional alleles. Mutation identification and calculation of mutation frequency were performed using Geneious 6.1 and the R statistical package (R Development Core Team 2014).
635,678 reads were included in the final analysis, accounting for 20.9% of all initial reads (Fig. 1). Among 81 diploid pigs, a maximum of 162 alleles is conceivably possible for each gene. However, after quality filtering, there were more than 162 clusters for each gene, indicating artifacts or errors introduced during PCR and sequencing. To compensate, a theoretical threshold of 0.6% was established to allow measurement of the relative abundance of putative alleles present in the sample population. As shown in Fig. 2A, the allelic variation and the functionality of IGLV alleles varied substantially among genes. The two dominantly expressed gene segment families, IGLV3 and IGLV8, showed more variation than other V segments, suggesting that the abundantly expressed gene have undergone selection pressure to expand their allelic repertoires. To compare synonymous and non-synonymous mutation frequencies, the number of V gene segment allele variants was determined at the nucleotide and amino acid sequence levels. As shown in Fig. 2A, the majority of nucleotide differences between alleles were non-synonymous. Indeed, for 10 of 12 gene segments in the IGLV3 and IGLV8 families, 73% of alleles were derived from non-synonymous mutations compared to 31% expected by random chance (p<0.0001, χ2-test). IGLV8-13, which has the richest allelic variation, has 35 amino acid alleles out of 47 total nucleotide sequence variants.
All of the functional alleles were in the IGLV3 family, the IGLV8 family, IGLV2-6, and IGLV5-14 (Fig. 2A), in agreement with the previously annotated locus (Schwartz et al. 2012b). A substantial number of alleles for these gene segments were non-functional due to frameshifts, premature stop codons, or both. Alleles of IGLV7-7, IGLV7-9 and one allele in IGLV3-6 encoded non-functional ORFs since they lacked the conserved cysteine residue at IMGT position 104 (2nd-CYS) (Schwartz et al. 2012b). To quantify the abundance of functional versus non-functional alleles, the percentage of predicted functional and non-functional products for each gene was calculated (Fig. 2B). Of twelve V gene segments possessing functional alleles, only IGLV3-2 was entirely functional. Another five genes (IGLV3-3, IGLV5-14, IGLV8-13, IGLV8-16, and IGLV8-18) were functional at a frequency less than 50 percent. Interestingly, while less than half of the identified alleles for IGLV3-6 were functional, the alleles were present at a frequency of more than 50% in the tested population. Indeed, this gene was recently identified as being completely missing in some animals, yet highly expressed in others (Schwartz and Murtaugh 2014). Meanwhile, IGLV3-4, IGLV3-5, IGLV3-6, and IGLV8-19 had a higher frequency of functional alleles.
Non-synonymous and synonymous mutations were observed in functional alleles across the V gene segment, in both framework and CDRs, especially in families containing a higher abundance of functional alleles, i.e. IGLV3 and IGLV8 (Fig. 3). By contrast, IGLV5 and IGLV7 families had a very limited number of mutations. The IGLV5 family contained only a single functional gene, IGLV5-14, which is expressed at extremely low levels (Schwartz et al. 2012b), and the IGLV7 family, which contains two pseudogenes. V gene segment families with higher levels of mutational variation, such as IGLV3 and IGLV8, showed Poisson frequency distributions, with one or two dominant alleles and substantial numbers of minor alleles (Supplementary Table 4). Analysis of read frequencies showed that V gene segments proximal to J were not underrepresented in Illumina reads, indicating that allelic variants were not artifacts accrued from sequencing of rearranged gene segments in which intervening DNA was excised (data not shown). It also is possible that minor allele artifacts might have arisen from inadvertent PCR amplification of rearranged V gene segments present in the lymphoid tissues used in this study. To address this question, we compared by Sanger sequencing functional V gene segments known to rearrange (3-2 and 3-3) and nonfunctional genes (3-1, 7-7, and 7-9) that were PCR-amplified from lymphoid (spleen) and non-lymphoid (lung) tissue in each of 5 independent pigs. In all cases, the V gene segment sequence was identical in lung and spleen. Even if rearranged V gene segments somehow were amplified from intergenic primer binding sites, arithmetic shows that the contribution to diversity would be a rare event. Only one V gene segment is present in a rearranged form in any single differentiated B cell. Thus, in a pure sample of differentiated B cells containing 22 amplifiable V gene segments, the rearranged V gene segment would contribute only about 2 to 3% of variation, having been diluted out by non-rearranged copies in the same cell and other cells. Not all B cells in lymphoid tissue are differentiated, and B cells constitute a minority of total tissue cells. Given that the PCR strategy was designed to exclude rearranged genes, it is reasonable to conclude that the allelic variation we report is due solely to analysis of germline DNA.
Bioinformatic analysis revealed that three low-frequency alleles were products of recombination. Two of the alleles contained sequences from genes belonging to the IGLV3 family, and the third was a chimera consisting of IGLV2-6 and IGLV8-16 fragments (Fig. 4 and Table 1). All three chimeric alleles had recombination breakpoints in framework 3, upstream from CDR3, and a conserved sequence motif (CCA/TCC/TCTGACCAT) in close proximity to the apparent 5' recombination sites in framework 3 known to mediate homologous recombination during meiosis (Fig. 4) (Baudat et al. 2010; Berg et al. 2010; Grey et al. 2011). The motif identified in IGLV3 family members differs by only a single nucleotide from the 13-bp motif (CCNCCNTNNCCNC) previously described in the porcine genome as well as in the human and mouse genomes (Baudat et al. 2010; Berg et al. 2010; (Tortereau et al. 2012).
Diversity of the primary antibody repertoire in individuals is limited by the germline repertoire, which is then expanded by combinatorial rearrangement and N-nucleotide addition by TdT in the gene segment junctions (Alt et al. 1987; Blackwell and Alt 1989). However, combinatorial diversity is highly restricted within the lambda locus, as more than half of the variable genes are non-functional and the functional gene segments belong almost exclusively to only two families (Schwartz et al. 2012b). In addition, the lambda locus exhibits low levels of somatic hypermutation and junctional diversity during B cell development (Butler et al. 2006; Wertz et al. 2013). Because of these limitations, germline allelic diversity may contribute importantly to the population repertoire at the potential expense of individual antibody diversity. Such an outcome could increase the variation in response to infection or vaccination depending on the ability of individuals to produce key protective antibody responses.
Allelic variation was observed in all lambda V gene segment families. Surprisingly, a large majority of alleles were due to nonsynonymous mutations resulting in amino acid sequence variants, both in functional and non-functional alleles, as shown in Figures 2 and and3.3. Functional alleles were restricted primarily to the IGLV3 and IGLV8 families, indicating strong selection pressure acting in these highly expressed families (Butler et al. 2006; Wertz et al. 2013). The IGLV8 family, in particular, appears to have undergone recent evolutionary expansion and is actively transcribed early in B cell development in yolk sac (Schwartz et al. 2012b, Wertz et al. 2013). In contrast, the poorly expressed gene segments and pseudogenes in IGLV5 and IGLV7 appear to be under relatively little selective pressure, presenting minimal non-synonymous mutation frequencies (Fig. 3).
The patterns of nonsynonymous and synonymous mutations shown in Fig. 3, in which mutations are distributed across the entire ORF, in both framework and CDRs, were previously observed, and differ from human VH gene segments, in which nonsynonymous mutations are concentrated in CDR1 and CDR2 hotspots (Chang and Casali 1994). Similar to our observations, the same study found that nonsynonymous mutations were not clustered in IGLV CDRs (Chang and Casali 1994). These findings indicate that framework regions as well as CDR are involved in antigen binding, but do not resolve if the bias toward nonsynonymous mutations reflects positive selection for diversity or a potentially inherent mechanism favoring nonsynonymous changes (Butler and Wertz 2012). The surprising paucity of synonymous allelic variants might be due to the non-random sample population of 81 individuals from the same genetic stock or to the selection program of the breeding company, or to other reasons. However, none of the possibilities would appear to explain how synonymous alleles would not be generated, or be selected against if present.
Due to gene duplication, paralogous V gene segments have similar structures and are organized between thousands of bases of flanking region. This genetic flexibility enables non-allelic recombination in the absence of special enzymatic machinery (Seidman et al. 1978). Our observation of non-allelic recombination shows that germline diversity of IGLV can be enhanced by recombination between gene segments in the same family or between two separate families. Indeed, there also is evidence of diversification by non-crossover homologous recombination (i.e. gene conversion) within the porcine kappa locus (Schwartz et al. 2012a). Because the amplicons in the present study were generated from diverse, yet similar sequences, it could be argued that the recombinants may have been generated during PCR. However, this is highly unlikely. Recombination was observed specifically between IGLV3 gene segments 3-6*01 and 3-1, and 3-2 and 3-3, and between 2-6 and 8-16. For the 3-6*01–3-1 recombinant, 274 identical reads were generated in total from 81 individual PCR reactions that were pooled for sequencing, but no recombinants were detected between 3-6*02 and 3-1, even though the reverse primer was the same for both 3-6 alleles (Supplementary Table 2). The 3-2–3-3 recombinant was revealed in 158 identical reads; there was no similarity between the primers for each gene segment. Furthermore, there is no homology between the primer binding sites used to amplify the IGLV8 family members and IGLV2-6, making the generation of such a chimera virtually impossible since the products were amplified independently. Of all three recombinant alleles, only IGLV3-6 and IGLV3-1 shared a common reverse primer, making the recombinatorial mechanism ambiguous (i.e. either crossover or non-crossover homologous recombination). Internal cross-overs during PCR between similar V gene segments of a highly related family like IGLV8, resulting in chimeric molecules, were not observed. Therefore, We conclude that the observed recombinants were due to recombination events in the genomes investigated.
Allelic variation in human immunoglobulin heavy chains shows that antibody repertoire diversity among humans may exhibit individual genetic variation and raises the likelihood that variation in the capacity for immunoglobulin diversity may be a general vertebrate immune response feature (Boyd et al. 2010; Kidd et al. 2012). Allelic polymorphisms also have been described in other non-MHC antigen receptor molecules in swine, including the CDR2-like region of CD4, which is homologous to the HIV gp120 receptor site of human CD4 (Gustafsson et al. 1993).
The Illumina sequencing and bioinformatic analysis generated a large number of allelic artifacts that exceeded the theoretical maximum of 162 alleles per V gene segment in many cases. Genotyping artifacts and errors have been noted by others for non-model organisms (Babik et al. 2009) (Sommer et al. 2013). As have others, we expected that artifacts would be relatively rare compared to true alleles, and so eliminated alleles with low reads, including all singletons and doubletons (Babik et al. 2009). It is possible that somatic hypermutation acting on un-rearranged germline lambda V gene segments generated artifactual alleles (Weiss and Wu 1987). However, in addition to previously described low levels of somatic hypermutation and junctional diversity during porcine B cell development (Butler et al. 2006; Wertz et al. 2013), germline mutations have been reported primarily from tumor cell lines and individuals with autoimmune diseases (Chezar et al. 2008; Kenny et al. 2001; Riboldi et al. 2003; Weiss and Wu 1987). For these reasons we conclude that the data represent allelic variation in germline lambda V gene segments.
The 13-bp motif "CCNCCNTNNCCNC" has been studied extensively in humans and is known to bind a histone methyltransferase, PRDM9, facilitating the formation of double strand breaks (DSB) and thereby increasing the recombination frequency (Baudat et al. 2010; Berg et al. 2010; (Myers et al. 2010). PRDM9 shows rapid evolution in different species including human, mouse, rat, macaque, and orangutan, exhibiting variations in the zinc-finger domain (Myers et al. 2010). One such motif discussed presently differs by only one base pair compared with the 13-bp motif found in the pig genome (Tortereau et al. 2012). This difference could be due to an allelic difference in pig breed, since the genome was derived from a single Duroc breed female (Groenen et al. 2012). Nevertheless, breed differences are expected overall to be unsubstantial due to extensive admixture over time between wild boars and domesticated pigs, and among diverse domesticated pig breeds of Asian and European populations (Ramirez et al. 2009; White 2011). The base similarities between these motifs and the motifs in human genes indicate conserved similarities in the antibody development of mammals (Table 1).
To summarize, we have discovered that the allelic variation of IGLV segment genes was substantial, and functional alleles were highest in the most highly expressed families, IGLV3 and IGLV8. At the population level, allelic variation appears to help maintain the potential for broad antibody repertoire diversity in spite of reduced gene segment choices and limited germline sequence modification. The trade-off may be a reduction in repertoire diversity within individuals that could result in increased variation in immunity to infectious disease and response to vaccination.
We thank Kent Reed for critically reading the manuscript and helpful suggestions. Funding was provided by the National Pork Board grant 10-139 (J.C.S. and M.P.M.). J.C.S. was supported by the Molecular Virology Training Grant T32 AI83196 from the National Institutes of Health and a Doctoral Dissertation Fellowship from the University of Minnesota. X.G. was supported in part by a University of Minnesota MnDRIVE Global Foods Venture fellowship.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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With a stay at Parco Tirreno Residence in Rome (Aurelio), you'll be convenient to Sistine Chapel and St. Peter's Basilica. This 4-star residence is within close proximity of Vatican Museums and St. Peter's Square.
Make yourself at home in one of the 182 air-conditioned rooms featuring refrigerators and flat-screen televisions. Rooms have private balconies. Complimentary wireless Internet access keeps you connected, and digital programming is available for your entertainment. Private bathrooms with bathtubs or showers feature complimentary toiletries and hair dryers.
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January 15th, 2016
Episode 1473 of 5181 episodes
To communicate Must Bubble Gum's long lasting flavor titled '45',BBR Saatchi & Saatchi, Tel Aviv created the world's stinkiest print ad. A print created using real food that causes bad breath: onions, garlic, fish and the sorts. VIEW OUTDOOR VIEW THE AD
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Social science, behavioral economics, cognitive psychology -- sound complex? Let's fix that. The Art of Charm Podcast is where self-motivated guys and gals, just like you, come to learn from a diverse mix of experienced mentors, including the world's best professional and academic minds, scientists, innovators, coaches, relationship experts, entrepreneurs, bestselling authors, and other brilliant minds. This show will make you a higher performer, a better networker, a deeper connector and, most importantly, a better thinker.


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We are actively engaged in offering defect-free range of Gas Absorption System in Mumbai, Maharashtra. Our system is manufactured by experienced professionals who use the latest technology and high-grade raw materials in order to ensure excellent quality. It is widely used in various industries such as chemical, paint, fertilizer and many more. Our Gas Absorption System is available at market-leading price. We delive
Garg Lab Solutions
A-2, Sainath Industrial Estate, Gr. Floor, Off Aarey Road, Goregaon (east), Maharashtra - 400063, India
We are offering Gas Chlorination System . Gas Chlorination System, offered by us, is vacuum operated and pressure type gas chlorinator product. These Gas Chlorination Systems are highly efficient, and can be availed from us at market leading prices. Product Variation we offer : Stand base mounting chlorinators Cylinder mounting chlorinators Floor mounting chlorinators
Exotic Elements
B-1 Sai Samarth, Link Rd, Chincholi Bunder, Malad-west, Maharashtra - 400064, India
Central Medical Gas Pipeline Systems For Breathing Gases
Central medical gas pipeline systems fort all breathing gases in the hospital with basic systems and their required accessories.
Home Security System (gas Leak Detector)
The gas leak detector features high sensitivity and reliability, compact size, 220V power supply and long stability &lifetime. It has a built-in transmitter to send an alarm signal, and has a built
Mann Electronic Securities
001, Indira Nagar Junction, Road No.-22/33, Wagle Estate., Maharashtra - 400604, India
Gas Flushing System In Jumbo Bags Ve-008n-sp
This Gas Flushing System (VE-008N-SP) is a term applied to a range of food Packing Techniques that Modify the ratios of main atmospheric gases to obtain conductive conditions that keep the food crispy & fresher, for an extended period of time on the shelf. This System establishes an atmosphere by drawing a partial Vacuum to remove the Ambient gases in side a Gas barrier package and then sealing the package with the p
Vijay Engineering
207, Manish Chamber,above Axis Bank, Opp.hotel Karan Palace, Sonawala Lane, Goregaon (e), Maharashtra - 400063, India
Based in Mumbai, Maharashtra, we are an established manufacturer and supplier of Current Injection Test System . This system is widely used in testing of electrical relay equipment and circuit breakers. It is also used for testing switchgear and CT commissioning. Made from high-grade material under a stringent quality control regimen, the current injection test system we offer is known for its accuracy, performance a
Automatic Electric Ltd.
570, Rectifier House, Naigaum Cross Road, Wadala, Maharashtra - 400031, India
Perfect Flexi Injection System
For all kinds of Flexible RPD's & Full Dentures, Pressable Acrylic dentures & Pressable Crown & Bridges (metal free copings) soft liners, Anti Snoring device, Night Guards.
Chromadent Dental Equipment
501,acme Shopping Center,cinestar Compound,trikamdas Road,kandivali West, Maharashtra - 400067, India
We manufacture a comprehensive range of Fixed Gas Monitoring System which is consist of state-of-the-art Digital Gas Transmitters or Analog Transmitters and Controllers ranging from simple 2 channel controllers to the most sophisticated GMS systems capable of connecting up to 128 transmitters. Features Fully certified by CMRI (Dhanbad) / CCE (Nagpur) Field transmitters provide industry standard 4-20 mA output
Uniphos Envirotronic Pvt Ltd
Ready Money Terrace, 167, Dr. A B Road, Worlinaka, Maharashtra - 400018, India
Buy excellence in the form of marine gas detection system at coffer-friendly prices, from us!Our effective and excellent quality analysis helps us in delivering the best in class range of products.
Micromate Automation Systems Pvt Ltd
Gala 247, Bmc Market ,station Road , Bhandup West, Maharashtra - 400078, India
Our dedicated staff is always on their toes to make certain that the raw material used is of high grade and certified by the experts as well. Due to our streamlined packaging system, we are capable of meeting both standard and customized packing needs of the clients. Moreover, we make use of quality packaging material.
Pes Health Care Pvt.ltd.
Ashiyana,105-b, First Floor, Sindhi Soci, Maharashtra - 400071, India
We are an eminent and leading trader of Medical Gas Pipeline System
Gmp Technical Solutions Pvt. Ltd.
309/316 Swastik Disha Business Parkwadhani Industrial Estate, Lbs Margghatkopar (west), Maharashtra , India
Features- for examination of gas hydrate formation pressure upto 350 bar and temperatures upto 100°c. Effectiveness & efficiency of thermodynamic and kinetic gas hydrate inhibitors can be analyzed camera for visual observation of gas hydrate formation and take photos and videos permits long term experiments of upto 30 days
Amar Equipments Pvt. Ltd.
6, Parmar Industrial Estate, Bail Bazaar, Kurla (west), Maharashtra - 400070, India
The company is the chief Precision Gas Analysis System Manufacturer and Supplier in India. This Precision Gas Analysis System offers uninterrupted observing production processes and research experiments. The Precision Gas Analysis System is provided by us at the market leading prices. Description High sensitivity Contamination resistant Fast response inert gas inlet Low sample consumption Extensive Input / Output Pro
Metal Power Analytical (i) Pvt. Ltd.
No. B-48, Raj Industrial Complex, Military Road, Andheri (east), Maharashtra - 400059, India
Or2410 Organic Gas Transmission Rate Test System
Or2410 is professionally applicable to the quantitative determination of organic gas transmission rate of films, composite films, sheeting, and packages.
Packone Sollutions Llp
B3, Devashree Park, Opp. Sandoz Baug Po, Kolshet Rd, Thane(w), Maharashtra , India
Deals in gas system, Pumps, Compressors, compressed air
Core Energy Systems Pvt. Ltd
6, Jigar Apartments,tai Pingle Chowk,tilak Road, Dombivli-east, Maharashtra - 421201, India
Deals in Garden Tools, fuel injections, fuel injection systems, Fuel Pumps, Measuring Tools, Power Tools, diesel vehicle parts, fuel pipes
Motor Industries Co. Ltd.
79, Dr. Annie Besant Road, Worli, Maharashtra , India
Deals in FRP Fume Hood
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Jayantilal Compound, Sion Trombay Road, Trombay Post Office, Sion Trombay Road, Trombay, Maharashtra - 400088, India
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Plot 78, Sector 23, Turbhe Service Industrial Area, Turbhe, Maharashtra - 400705, India
Deals in Stainless Steel Tube Fittings, stainless steel tube fitting, gas panels, Gas Distribution Panel, Pipe Couplings, Tube Bender, Stainless Steel Snubber, Metal Tubes, Hydrocarbon Trap, Moisture Trap, Braided Hose, Gas Manifold, Bore Through Connectors, stainless steel tube fitting, Toggle Valves, Gas Manifold Systems, 3 Way Manifold Valves, Tube Fittings, Stainless Steel Braided Hose, Tube Clamp
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Deals in gas suppression system, surveillance systems, fire alarms system, Home Automation Systems, surveillance systems, fire alarms system, Access Control System, Home Automation Systems
Camint Enterprises
604/atharva Chs, N.m.joshi Marg, Chinchpokli (e), Maharashtra , India


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It is Monday and morning and this week I turn 50. What better song than "Not Dark Yet But Its Getting There." Dylan's first self-titled album came out in 1962. I was two years old. 48 years later he is … Continue reading
Mark Hinton
The very first album I ever owned was Live at Folsom Prison, a gift from my cousins. Johnny Cash was as big at the end of his life as he was at any time in his long and storied career. He … Continue reading
It would be hard to single out just one favorite song by the Clash, but "Straight to Hell" is certainly near the top of the list. "The only band that matters" remains one of the most influential and interesting bands … Continue reading
Hank Williams, Jr. seldom disappoints. This song has been a favorite for more than 25 years. When I am feeling blue and lost in the Midwest, Bosephus and this song always bring me up again. Country music may not be … Continue reading
"People are Crazy," by Billy Currington. The bones of Christian theology are contained in this song. I have little time for most "sacred music" and absolutely no time whatsoever for that particularly awful stuff marketed as "Christian Music." I do … Continue reading
The best baseball books are autobiographical. This is because baseball is the most measurable of games. We can look at a player's statistics and the box scores of games and know the bones of the sport. The flesh of the … Continue reading
I have always thought of movies as the laziest of arts. I do not mean their creation. I have seen movie sets. I know how many people it takes to create only a minute or two of film. There is … Continue reading
Every spring for more than 25 years now, I re-read Hemingway's "The Big Two-Hearted River." It is to my mind the best story about fishing ever written. It is also one of the 5 best short stories ever published. In … Continue reading
Anyone who loves baseball and knows how to write wants to write a baseball book. Baseball is the most literary of the sports. It's long season, the un-timed nature of its games leads inevitably to stories– of past games and … Continue reading
In honor of the upcoming baseball season, I will be reviewing baseball books. There are good and even a few great books written about basketball, football, and hockey. But in baseball there are so many more. Baseball is at its … Continue reading


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Comments:28.06.2015 at 03:56 Fejas:
Certainly. So happens. We can communicate on this theme.


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Just got back from a great weekend at the resort. We were kind of skeptical due to the latest reviews but we decided, "it's for the kids" and what a great decision it was. Check in started the trip with a great impression. Elizabeth moved our pool view room to the bldg we chose,(direct access to splashtopia,bldg 26), had a complimentary refer and crib sent to the room, explained everything and checked us in at 1pm..all in about 15 min. The room was spacious and clean and the ground floor patio was perfect for the kids to play on the grass. Maid service was nice and early,except they forgot bath towels, fixed in 10 min with a phone call.FOOD: Brunch at bluEmber was good and reasonably priced and both the kids ate free because they are under 5. Lunch at the pool was better than expected. The price for tropical drinks are outrageous (bring your own). The girls loved the hand scooped ice cream.Numerous restaurants across the street for dinner
try Acqua Pazza awesome! POOL: It's like a water park people, it's going to be busy, the water is going to be murky, and yes, you are going to get WET! There is a chemical called chlorine, it kills bacteria, it doesnt remove suntan lotion and oils from water. Ever been to the beach or Lake Havasu, it's actually 10 times dirtier with raw sewage,harmful levels of carbon monoxide and NO chlorine to kill anything....I got to splashtopia on fri,sat and sun when they opened at 9am and got 2 padded chairs with an umbrella each day. I put down my towels and some personal items and went back to get my family within the well posted (right where you get your towels) 20 min. time limit. No problems, my stuff was still there when I returned. I have been to numerous family resorts and pool chairs are always a problems, including Atlantis, and they have 10,000 chairs. Get there early and follow the rules! The kids loved the beach area and the lazy river, my 3 1/2 year old loved the water slide although after riding it 10 times, the staff changed and the new teenage employee said she is 2 in. too short and wouldnt allow her to ride it! I think the height limit should be lowered for the small slide to 36"! CONS: My only honest complaint has nothing to do with the resort at all, the small black birds are relentless and actually try to attack you! I got pecked in the head by one! BEWARE :)
Overall, we had a wonderful weekend,met some very nice families and will definitely be back again!
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- Rancho Palmas Resort
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Click here for the Governors Vision Statement
The school governors are a group of individuals drawn from a variety of backgrounds. Some are parents, some are staff and some are members of the local community. They all have the same aims - to establish the strategic direction for the school, to challenge and support the staff, and to monitor school finances.
At Fernhurst Primary School, the governors become involved in many aspects of school life: not only do they attend meetings and consider school data, but they also run the school cricket club, hear readers in class, bake cakes at the after school club and support school assemblies and events. Their knowledge of the school, its staff and the local community allow them accurately to assess the progress and needs of the school.
Please click here to view Governors' Attendance Information.
Please click here to view the Governors' List of Pecuniary Interests.
Please click here to view the Structure for the Committees.


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Nevion, formerly Network/VPG, announced late last week a major investment in company resources, including increasing its engineering staff by 20 percent and sales staff by 30 percent, to support development and sales of technology for point-to-point broadcast applications as well as IP media networks.
The move is the result of increased investment from its existing owners as well as recognition of the increasingly important role of content contribution via IP media networks. Oddbjørn Bergem, Nevion's CEO, announced the changes.
Going forward, the company will be structured with two divisions, each led by longtime Nevion executives. The media networks division, led by Eugene Keane, will serve the carrier-class video transport and management needs of service providers, through the Ventura platform. The broadcast technology division, led by Thomas Heinzer, will deliver integrated, broad-based video transport, routing and processing solutions to broadcasters, primarily through Nevion's Flashlink and VikinX product lines.
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Privatna soba
2 gosta
1 spavaća soba
1 krevet
My place is close to the city centre and parks. You'll love my place because of the cosiness and the space.20 minutes from Napier, 8 minutes walking distance from the show ground where the sunday farmers market happens.
- I don't charge for cleaning so try to leave the house as you found it, thank you.
- You will have to share the house with the owner of the house.
Otkažete li više od 24 sata prije početka rezervacije, dobit ćete potpuni povrat novca. Otkažete li manje od 24 sata prije početka rezervacije, nećete dobiti povrat novca za prvo noćenje u okviru rezervacije.
I am a working mum of two children,french and I just bought a house which I am really proud of. and am going overseas for the months of december and January of this year and decided to open my house to people who want to come to sunny Hawkes Bay in the summer months.
I love living in Hawkes Bay where there is so much to do especially in these summer months (park, beaches, art deco capital, shopping, te mata peak....)
I myself have used airnbnb as a guest and I loved it, much cosier and relaxed than any other ways to go on holidays.


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Contains 100% natural vegan botanical ingredients. 76% organic. A divine blend of pure botanical ingredients to softly + gently refine and exfoliate even sensitive facial skin. made with hand-milled organic coconut, organic oats, rice powder, coconut milk + jojoba meal, which gently yet effectively polish and buff skin to a healthy glow. use just once to twice weekly for more even-toned, balanced and delightfully soft, radiant skin.
be mindful: huna Softening Polish is an all-natural, preservative-free formula. careful not to allow water to enter the jar, as water will compromise the product quality and integrity.
Ingredients: 100% natural, delicious vegan
avena sativa (organic oat) meal, cocos nucifera (organic coconut), cocos nucifera sucrose (organic coconut palm sugar), cocos nucifera extract (coconut milk) powder, oryza sativa (rice) powder, matricaria chamomilla (chamomile) flowers, lavandula angustifolia (lavender) flowers, calendula officinalis (calendula) flowers, simmondsia chinensis (jojoba) meal, musa sapientum (banana) fruit extract, licorice root extract, sea buckthorn extract.
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We met up here for a family Sunday lunch. The staff treated us as if we went there everyday super friendly and nothing was any trouble to them. The meal it self was an excellent carvery and plenty of it. In fact although we live an hour away we are going back in the near future.
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- Also Known As:
- Mildmay Arms Hotel Queen Camel
- Mildmay Arms Queen Camel, Somerset, UK


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The Dumping Grounds
January 6, 2017 | 5 Comments » | Topics: The Dumping Grounds
Motherhood In 34 Seconds
Most advanced car cassette player ever made (1988)
What's inside a police car
Documentary: The Boy Who Can't Forget
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Bob Frapples
The real Twilight Zone is that a country that voted a black man into the highest office TWICE is still considered "racist" by people that have no clue what is the true definition of racism. I guess they're the same people that think every person that doesn't agree 100% with their ideology is Hitler. They are also the same people that think if they keep equating a college education with intelligence, we'll forget that most of those assholes are spending $100K taking Advanced Feminism classes only to make $30K working retail and supplementing their income by creating a goFundMe page so they can go to Burning Man.
Bill Sherman
boo hoo sucks to be you, knuckledragger.
Bob Frapples
Not really, Trump is in office and he's getting all you lazy, whiny, pussies in order.
Bill Sherman
you just don't know how screwed over you are yet. that's how f*cking stupid are. tump does care a rat's ass about you.
Bob Frapples
Oh, and Obama cared about you? LOL. Delusional liberal.
Tell me, did Obama close Guantanamo like he promised? Did Obama eliminate all the lobbyists in DC like he promised? Did Obama have the most transparent administration like he promised?
That would be a "no" answer for all of those questions. Trump has made good on most of his campaign promises and it's only been two weeks.
The fact that even after the housing bubble of 2008, all that stimulus money, all those people that lost their retirement money due to the bad decisions of all those Wall Street broker's… How many people did Obama put in jail? How many? *crickets*
Had that happened under Trump, you morons would be trampling over each other in the streets protesting the injustice and calling for Trump's head on a platter. Instead, you lame fooks all drank the Obama kool-aid, sat back and just assumed that you'd easily win in 2016 with Clinton.
You were wrong, you lost. And you lost, not because someone cheated, not because voter turn-out was poor, you lost because of the continued failed policies coming from the left.
Now you can sit back, relax, and let President Trump do his job. The great thing about it is, because you liberals changed the rules and stacked the deck while you guys had the majority and never thought about what would happen if the GOP had control, Trump doesn't have to cater or listen to you. #MAGA