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Erbium-Doped Fiber Amplifiers, Principles and Applications, by Desurvire
Desurvire, Emmanuel
Librería en AbeBooks desde: 15 de febrero de 2001Cantidad: 1
Imagen del editor
Librería en AbeBooks desde: 15 de febrero de 2001Cantidad: 1
Detalles bibliográficos
Título: Erbium-Doped Fiber Amplifiers, Principles ...
Editorial: Wiley-Interscience
Año de publicación: 2002
Encuadernación: Paperback
Condición del libro:Good
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How is light amplified in the doped fiber? How much spontaneous emission noise is generated at the output? Do detectors with optical preamplifiers outperform avalanche photodiodes? What are the current types and architectures of amplifier-based systems?
Erbium-Doped Fiber Amplifiers: Principles and Applications
These are just a handful of the essential questions answered in Erbium-Doped Fiber Amplifiers—the first book to integrate the most influential current papers on this breakthrough in fiber-optics technology. Written by one of the pioneers in the field, this unique reference provides researchers, engineers, and system designers with detailed, interdisciplinary coverage of the theoretical underpinnings, main characteristics, and primary applications of EDFAs. Packed with information on important system experiments and the best experimental results to date as well as over 1,400 references to the expanding literature, Erbium-Doped Fiber Amplifiers illuminates such key areas as:
In so doing, the book sheds light on many new frontiers of knowledge, such as inhomogeneous modeling and nonlinear photon statistics, and demonstrates the many broadening benefits of EDFAs, including their polarization insensitivity, temperature stability, quantum-limited noise figure, and immunity to interchannel crosstalk. With the demand for transoceanic and terrestrial communications growing at a steady rate of 25% a year, the arrival of Erbium-Doped Fiber Amplifiers—destined to significantly expand the capabilities of today's hard-pressed lightwave technology-couldn't be more timely.From the Publisher:
Organized into three sections which can be read independently. Part A is essentially theoretical and deals with the fundamentals of light amplification and noise in single-mode fibers as well as principles of photodetection of digital signals with optical amplifiers. The second section outlines erbium-doped fibers' characteristics from spectroscopic features to fiber amplifier gain and saturation properties. Lastly it describes both device and systems applications of erbium-doped fibers. Integrates laser physics and communications.
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Don't miss out on a lower price on this hotel
Get an overview of this hotel4-star hotel with 2 outdoor pools and full-service spa
Popular property highlights
Situated by the sea, this spa hotel is within a 10-minute walk of San Francesco Beach and St. Francis Beach. Villa La Mortella and Port of Forio are also within 1 mi (2 km).
Hotel Features
2 outdoor pools, a full-service spa, and a restaurant are available at this hotel. Free buffet breakfast is provided, as well as free WiFi in public areas, free self parking, and free train station pick-up. Additionally, an indoor pool, a bar/lounge, and a poolside bar are onsite.
Room Amenities
All 52 individually furnished rooms feature free WiFi and 24-hour room service. For a bit of entertainment, guests will find TVs with satellite channels, and other amenities include balconies and minibars.Information missing or incorrect? Tell us!Opens in a new window
Hotel La Scogliera
Hotel Amenities
Hotel Amenities
Hotel La Scogliera features a full-service spa, 2 outdoor swimming pools, an indoor pool, and a sauna. The hotel offers a restaurant. Guests can unwind with a drink at one of the hotel's bars, which include a poolside bar and a bar/lounge. Guests can enjoy a complimentary breakfast. Wireless Internet access is complimentary.
This Forio d'Ischia hotel also offers spa services, a library, and a terrace. Complimentary self parking is available on site.
- 24-hour front desk
- Total number of rooms - 52
- Babysitting or childcare
- Bar/lounge
- Free breakfast
- Concierge services
- Elevator/lift
- Full-service spa
- Hair salon
- Pool umbrellas
- Airport transportation
- Tours/ticket assistance
- Free WiFi
- Number of outdoor pools - 2
- Library
- Spa treatment room(s)
- Multilingual staff
- Garden
- Terrace
- Poolside bar
- Restaurant
- Safe-deposit box at front desk
- Free train station pickup
- Free self parking
- Beach umbrellas
- Beach sun loungers
- Pool sun loungers
- Sauna
- Shopping on site
- Spa services on site
- Indoor pool
Family Friendly Amenities
- Family Hotel
- Outdoor pools
- Indoor pool
- Free Wi-Fi
- Babysitting or childcare
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Balcony
- Air conditioning
- In-room climate control (air conditioning)
- Minibar
- Private bathroom
- Shower only
- Hair dryer (on request)
- In-room safe
- Television
- Desk
- Satellite TV service
- Free WiFi
- Room service (24 hours)
- Individually furnished
- Cribs/infant beds (surcharge)
Where to Eat
Guests are offered a complimentary buffet breakfast.
Onsite venue - This restaurant specializes in local cuisine and serves breakfast, lunch, and dinner.
24-hour room service is available.
Nearby Things to Do
2 outdoor swimming pools are on site along with an indoor pool. Other recreational amenities include a sauna.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Bicycle rentals nearby
Spa Services
The onsite spa has massage/treatment rooms. Services include massages, facials, body scrubs, and body treatments. The spa is equipped with a spa tub. A variety of treatment therapies are provided, including aromatherapy and reflexology.
- Reflexology
- Body scrubs
- Aromatherapy treatments
- Spa tub in spa
- Massages
- Body treatments
- Facial treatments
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Check-out time is 10 AM
Payment types
Children and extra beds
- Children are welcome.
- Cribs (infant beds) are available for EUR 15 per day.
- Pets allowed
- Restrictions apply
- For more information contact the property at the number on the booking confirmation
You need to know
Extra-person charges may apply and vary depending on property policy.
- A tax is imposed by the city: EUR 1.50 per person, per night, up to 7 nights. This tax does not apply to children under 18 years of age.
Optional extras
- Crib (infant bed) fee: EUR 15 per day
Hotel Name
- Scogliera Forio d'Ischia
- Scogliera Hotel Forio d'Ischia
- Hotel Scogliera Forio d'Ischia
- Hotel Scogliera
We should mention
All guests, including children, must be present at check-in and show their government-issued photo ID card or passport. Cash transactions at this property cannot exceed EUR 2999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation. Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation.

subset: commoncrawl


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Fill your Easter basket this year with homemade chocolate cream-filled eggs. Making them at home is easier than you think — and is even a fun project do with kids. Everything is better when it's homemade and these eggs are no exception. With a few ingredients and some tools, you can whip these up before the egg hunt is over.
Click here to see the Chocolate Easter Egg Recipe
These eggs have a hard chocolate shell and are filled with a creamy center. For our recipe, we've used Wilton milk chocolate candy melts, which are ideal for melting and molding candies. Try looking for these or another brand of candy-coating or confectionery coating chocolate. It's also best to use a plastic or silicone egg mold that can be found at any craft or baking store, especially around Easter.
So, this Easter, try making your own candies at home. Fill your Easter baskets with these homemade treats and make sure to have them for dessert after Easter dinner. This is a great weekend kitchen project — and one that yields a chocolate cream dessert!
Emily Jacobs is the Recipe editor at The Daily Meal. Follow her on Twitter @EmilyRecipes.
Canadians can relate to the chicken who crosses the road for Tim Hortons
7Up tainted with methamphetamine sent several people to the hospital in Mexico
Drinking a lot – in a few hours or over time – can take a significant toll on your physical and mental health
An East Village resident wants to ban boozy, bottomless brunch
Move over, Dragon's Breath, Pepper X is going for the hottest pepper title


text: Newly appointed GDF Chief of Staff has issued a stern warning to ranks who are engaged in deviant behaviour Posted by: admin Posted date: November 01, 2016 In: Top Stories Share this: Tweet Share on Tumblr Pocket Email Print ‹ Previous Next › Related posts UNAIDS negotiates lower price for one pill HIV treatment Desist from playing loud music – Senior Superintendent Cooper Elderly WCD man dies in 'shallow drain'following road accident AFC objects to Parking Meter contract with Smart City solution Leave a Comment Click here to cancel reply. Name* Email* Website Submit Comment Notify me of follow-up comments by email. Notify me of new posts by email.


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Former church hall conversion in prestigious area of Castlehead, offering four or five bedroom accomodation for rent . Full refurbishment almost complete, to be available from early October.
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If all of it appears to be like and behaves exactly the same, you could be taking a look at pretend evaluations meant to bait you into registering and funding a trading account as a result of a certain advisable broker. Hunt for diverging viewpoints and open conversations, in some cases the programs that are not heavily publicized will do a far bet… Read More
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Das Internet wimmelt mittlerweile von Tipps pro binäBezeichnung für eine antwort im email-verkehr Optionen. Man könnte meinen, dass jeder ein professioneller Händler ist – so wie jeder dennoch einer WM ein Fußballtrainer ist.Sehr schöner und ausführlicher Begleiter. Ich denke aber, dass die einfachste Möglichkeit online Geld nach verdiene… Read More
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Music, News & Politics, Society & Culture, History, Sports & Recreation, TV & FilmFollow
September 22nd, 2015
Episode 272 of 1040 episodes
Cette semaine Jacques nous propose un livre par Phillipe Reyt .. Cinq à table. (Cette semaine Jacques nous propose un livre par Phillipe Reyt .. Cinq à table. )
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Social science, behavioral economics, cognitive psychology -- sound complex? Let's fix that. The Art of Charm Podcast is where self-motivated guys and gals, just like you, come to learn from a diverse mix of experienced mentors, including the world's best professional and academic minds, scientists, innovators, coaches, relationship experts, entrepreneurs, bestselling authors, and other brilliant minds. This show will make you a higher performer, a better networker, a deeper connector and, most importantly, a better thinker.


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Pet Sitting & Drop In Visits in Ashton Corners, WI
Book a pet sitter to stop by your home a few times a day to feed and play with your cat or dog.
I am dog's best friend!
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How about a long walk today?
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a person who says hi to dogs first
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|Waunakee, WI
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The next time you head out of town and need someone to take care of your pets — and check in on you home — turn to Rover. It's easy to find a loving Ashton Corners pet sitter on Rover who'll give your pet one-on-one attention while you're away, and take care of your home. Search from hundreds of trusted pet sitters in Ashton Corners, WI, read sitter profiles, and reach out to sitters who seem like a good fit for you and your pet(s). We know it can be tough to leave your pet, which is why we encourage every pet parent and sitter to have a Meet & Greet before booking the stay. Then, when you're ready, book and pay for your house and pet sitter all through Rover — it's easy, safe, and cashless. You'll have the peace of mind knowing that your sitter has free premium insurance, a team of safety experts available 24/7, and will send you cute photo updates throughout the stay. Rover is the easiest way to find trustworthy Ashton Corners pet sitters and avoid the kennel.


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Hello from Minnesota
You betcha, spring has finally arrived and it's wet. Mt favorite stream, the Root, and several of the small towns and state parks around it have flooded. My prayers go out for the people in SE MN and, yes, also for the trout.
Always looking for info on the trout streams of Se MN, Western Wisc., and anywhere else the the Driftless area. Also, I'd like to know more about Black Hills fly fishing...it's only a days drive which is a lot closer than the Rockies.
Al Barton
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MICHAEL Clarke has weighed in on the debate over who the superior batsman between Steve Smith and Virat Kohli is.
His answer? Both of them.
"In limited-overs cricket, I think Virat is ahead of Steve, but just by that much. Smith I believe is a better Test batsman," Clarke said during a conversation with Indian great VVS Laxman organised by host broadcaster Star Sports.
It's an opinion that it is hard to argue against.
- 7/281MA Chidambaram StadiumIND won by 26 runs (D/L)9/137Visit Match Centre
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LIVE stream the India v Australia ODI series on FOX SPORTS. Get a free 2-week Foxtel Now trial & stream LIVE within minutes. SIGN UP NOW >
SLEDGE OFF: India promise to fight fire with fire
WARM UP: Smith, Stoinis star as Aussies win in India
Alongside sitting atop the ICC's Test batting rankings, five spots and 106 points above Kohli, Smith's record in the five-day arena is phenomenal. Still only 28 years old, he has already scored 20 centuries and 5370 runs in the format at an average of 59.66 across 56 Tests — Don Bradman is the only man to boast a better average among those who have score more than 5000 Test runs. Kohli's record in the format is hardly poor — 17 centuries, 4658 runs at 49.55 across 60 Tests — but at this stage it is still clearly a tier below Smith's.
The opposite can be said when it comes to white-ball cricket. Sitting 13th on the ICC ODI batting rankings, Smith's reputation as a one-day batsman has grown over the last few years and his record — eight centuries, 3187 runs at 44.26 across 98 ODIs, strike rate of 87.48 — compares favourably to most. Kohli however, is in a different league altogether.
The 28-year-old sits atop the ODI rankings and is on track to go down as one of the format's greatest ever players. Boasting the highest average (55.75) of any batsman who has scored more than 2000 ODI runs and tied second with Ricky Ponting for the most centuries (30), Kohli has scored 8587 runs in 186 innings. Those runs aren't coming slowly either, with his strike rate a healthy 91.72. Over the last two years he has averaged 83.37.
It's hardly worth comparing the two when it comes to Twenty20 internationals. Kohli's T20I average of 53.82 is the best of any player who has featured in 20 innings, more than 12 runs superior to second-placed Joe Root (40.33).
If there is one thing weighing in Smith's favour heading into this series it's that he boasts a better ODI average against India (66.71) than Kohli does against Australia (55.66). Though it should be noted that Smith has only batted seven times against India — all in Australia — while Kohli has had 21 innings against Australia.
Whatever the case, Clarke does not believe the two men will decide the one-day series with their bats.
"I think over the next few days, everybody would want to speak about Steve Smith vs. Virat Kohli but at the end of the day, it comes down to one thing, and that is the team that wins.
"It doesn't matter who makes the runs — Kohli or Smith. At the end of the day, your job as a captain is to win."
Clarke tipped the Australians to win the series 3-2, with Laxman backing the hosts to win 4-1.


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Old cut diamond 1.40ct, I/Si1, to a later 'crown' style mount. Platinum
Old cut diamond 0.91ct, H colour and VS clarity, to a platinum mount, diamond set shoulders and 18ct yellow gold shank.
Pave set diamond cluster ring, 0.50ct G colour, VS clarity. 18ct white gold.
Antique diamond cluster ring.
Graduated five stone diamond ring between 2 diamond set bands. Total diamond weight 1.05ct, G colour, VS clarity.


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Science chiropractor, Dr. Alexander Jimenez investigates the methods described in treating a tight calf muscle.
Assess The Calf Complex
In the calf complex, the medial sural nerve descends between the two gastrocnemius heads and also at mid-calf level combines with a branch of the peroneal nerve to form the sural nerve(1,2). As we get older, the body's connective tissue gets less pliable. Nerves are naturally surrounded by connective tissues — sometimes they even run through connective tissues, so with aging the nerves can get trapped, trapped or tethered to surrounding muscle or fascia(3).
This can manifest as a feeling of tightness deep in the calf muscle that never changes, no matter how much the customer stretches the muscles.
Action! Evaluate The Calf
The perfect method to appraise the calf is to palpate the muscle in a relaxed position (see Fig 1. below). Begin with your patient's unaffected calf; palpate (feel) deeply between the gastroc heads supporting the knee and work down the calf into the Achilles tendon. This will give you a sensation of the deep neuro-myofascial tissue enclosing the tibial nerve, and what 'normal' feels like in this patient. Beware: it's generally quite uncomfortable to do so because of the sensitive neural structures.
Then feel the affected calf in the exact same way. If there is a difference in the deep center section (eg tightness, pain, lumpiness) and if, when you press, then it replicates their usual 'pain' or 'tightness', it might indicate a nerve tethering problem that needs hands-on intervention.
Assess the nerves of the lower limb by using the slump test (see Fig 2, below) or the straight leg raise test to cross-check your client's neural system and compare sides.
Treat The Neural Calf Complex
Related Posts
Once you've found something asymmetrical, you can treat the problem.
Warning: this therapy could be painful, but in my experience you need to treat very firmly to get results. Warn your patient.
Action! — Friction The Deep Structures
In the exact same position (see Fig 3, below), ensure finger tips are together and palpating right on the tight, painful area. With firm pressure, friction across the line of the nerve with your finger tips going into the left with both hands and then to the right (firm treatment is essential).
Repeat this along the length of the tibial nerve down the area where the patient has identified a difference in the feel compared to the other side. After you have loosened the neuro-myo-fascial constructions, get your client to walk or jog to see how it feels.
Action! Educate Your Client To Self-Treat
Sitting with knees bent, they should use their thumbs to palpate; ensure they can replicate the sensation you produced with your treatment. This way, your active patient can make chronically tight and painful calves a thing of the past.
Sourced From:
Mark Alexander was sports physiotherapist to the 2008 Olympic Australian triathlon team, is lecturer and coordinator of the Master of sports physiotherapy degree at Latrobe University (Melbourne) and managing director of BakBalls (www.bakballs.com).
Scott Smith is an Australian physiotherapist. He works at Albany Creek Sports Injury Clinic in Brisbane, specialising in running and golf injuries. He is currently working with Australian Rules football teams in Brisbane.
Sean Fyfe is the strength and conditioning coach and assistant tennis coach for the Tennis Australia National High Performance Academy based in Brisbane. He also operates his own sports physiotherapy clinic.
Mark Palmer is a New Zealand-trained physiotherapist who has been working in English football for the past five years. He has spent the past three seasons as head physiotherapist at Sheffield Wednesday FC.
Chiropractor💡 Author • Researcher • Injury & Trauma Clinician • Wellness Educator • 915-850-0900 📞
We Welcome You 👊🏻.
Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, functional strength training and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.
Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, functional strength training and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.
We use Specialized Chiropractic Techniques, Balanced Diet Plans, Agility Training programs, Cross-Fit techniques, the PUSH-Rx Rehabilitation System and a highly specialized program for our Veterans.
We've been blessed to use our methods with thousand of El Pasoans over the last 27 years. This has allowed us to improve health and restore true fitness through researched non-surgical methods and wellness programs. These programs are natural and use the body's own ability to achieve goals of improvement, rather than introducing harmful chemicals, controversial hormone replacement, surgery, or addictive drugs. We want you to live a life that is fulfilled with more energy, positive attitude, better sleep, less pain, proper body weight and informed on how to maintain this way of life.
As an extension to dynamic rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high performance exercises and advanced agility options. We are very proud to have teamed up with the cities premier therapist and trainers in order to provide high level competitive athletes the option to push themselves to their highest abilities within our facility.
Come learn how to improve your health for yourself and your loved ones.
With a bit of work, we can achieve optimal health together, no matter the age or disability.
Its all about: LIVING, LOVING & MATTERING! 🍎
God Bless
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11860 Vista Del Sol, Suite 128


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Amtrak won't stop in Encinitas or South Carlsbad
Agreement with North County Transit District to end October 9
Ken Harrison 8:30 a.m., Sept. 22
A splendid day on the waterfront!
Photo by xenubarb
Posted February 15, 2012
Ken Harrison 8:30 a.m., Sept. 22
Mike Madriaga 7 a.m., Sept. 22
Matt Potter 4 p.m., Sept. 21
Dave Rice 3:15 p.m., Sept. 21
Garrett Harris 2 p.m., Sept. 21
Ken Harrison 1 p.m., Sept. 21
Edward Magdaleno noon, Sept. 21
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Tazobactam/piperacillin (TAZ/PIPC), which is often combined with continuous renal replacement therapy (CRRT), induces renal excretion and is thought to have a high component removal rate for blood purification. CRRT procedures vary depending on the country, region, and institution. It is not clear whether the dose of TAZ/PIPC for use in Japan can be determined based on studies conducted in other countries. Therefore, in this study, we examined the suitability of recommended dose in Japan.
The study subjects consisted of 10 patients who received TAZ/PIPC during CRRT in the intensive care unit of Hyogo College of Medicine, Nishinomiya, Japan. We used a one-compartment model to characterize and parameterize the pharmacokinetics of TAZ/PIPC because their blood levels were eliminated monoexponentially.
Compared with the data of healthy adults, the half-lives (t1/2) of both PIPC and TAZ were prolonged while their clearance rates decreased.
For the continuous hemodiafiltration procedure adopted in Japan, we concluded that the dose and frequency were appropriate because the patients who received PIPC/TAZ 2.25 g twice a day during continuous hemodiafiltration maintained appropriate blood levels of both PIPC and TAZ.
Tazobactam/piperacillin (TAZ/PIPC) is an antibiotic combination commonly used in hospital intensive care unit (ICU) and is often combined with continuous renal replacement therapy (CRRT), introduced for treating sepsis and acute renal failure. According to the package insert of TAZ/PIPC (Zosyn®, Taisho Toyama Pharmaceutical Co., Ltd., Tokyo, Japan), the dosage for patients with sepsis or pneumonia is 4.5 g three to four times per day.1–3 However, the regimen should be adjusted based on decreased renal function rather than the renal excretion of the drug. According to the Sanford guide to antimicrobial therapy 2014, the recommended dosages in renal impairment and during CRRT are 2.25 g three to four times and 2.25 g four times per day, respectively.
Because both PIPC and TAZ are low molecular weight compounds (535.57 and 300.29 Da, respectively) with low protein binding rates (16% and 4%, respectively), the component removal rate during blood purification is high.4 In Europe and the USA, it has been reported that 4.5 g of TAZ/PIPC twice a day, which comprises the regimen for CRRT, is low while 4.5 g thrice a day is suitable.5,6 In particular, it is recommended to administer patients with sepsis TAZ/PIPC 4.5 g four times a day for the first 48 h.7 The procedure adopted for CRRT in the USA was reported to be as follows: blood flow, 150 (120–170) mL.min−1 and the amount of blood purification, which is the sum of the dialysis fluid and filtration flow rates, is commonly 35 mL·kg−1·h−1.8 In the UK, the following procedure was reported: blood flow, 150–200 mL.min−1 and amount of blood purification, 32 (29–36) mL·kg−1·h−1.9 In Australia and New Zealand, the following specifications were reported: blood flow, 200 mL.min−1 and the amount of blood purification, 24.3 mL·kg−1·h−1.10 In Japan, the following procedure was reported: blood flow, 80 mL.min−1 and the median amount of blood purification, 16 mL·kg−1·h−1.11 These reports indicate that the values vary depending on the country, region, and institution.
The modality setting for CRRT in Japan tends to be lower for both blood flow and blood purification than what is used in Western countries. Therefore, it is not clear whether the dose of drugs used in CRRT in Japan can be determined based on studies performed in other countries. Presently, no study has examined the pharmacokinetics (PK) of TAZ/PIPC during CRRT in Japan. Although the recommended dosage of TAZ/PIPC during CRRT is 2.25 g three to four times per day in Japan, it is suggested that a higher dose regimen may be required in studies in other countries. Therefore, we examine the suitability of the current dose of TAZ/PIPC recommended for use in CRRT procedures in Japan.
By the Shiba's report,12 which TAZ/PIPC was administered to healthy Japanese male volunteers, in the group of TAZ/PIPC 4.5 g four times per day, the half-lives (t1/2), maximum plasma concentration level (Cmax), the area under the plasma concentration–time curve (AUC), the total body clearance (CLtot), and the volume of distribution (Vd) of PIPC were 0.99 h, 267 mg/L, 300 mg·h/L, 13.5 L/h, and 13.7 L, respectively. The t1/2, Cmax, AUC, CLtot, and Vd of TAZ were 0.84 h, 32.5 mg/L, 38.7 mg·h/L, 13.0 L/h, and 13.6 L, respectively.
This study was approved by the Ethics Committee of Hyogo College of Medicine. The study protocol and implications were explained to the participants verbally and in writing. The participants provided their written informed consent prior to participation in this study.
The study subjects consisted of 10 patients who received TAZ/PIPC (Zosyn) for the treatment of infectious disease during CRRT in the ICU of Hyogo College of Medicine, Nishinomiya, Japan between December 2011 and March 2015. Of these 10 patients, 6, 3, and 1 received TAZ/PIPC 2.25 g twice and three times a day and 4.5 g twice a day. For patients who received continuous hemodialysis (CHD) as CRRT, the dialysis fluid flow rate was set at 800 mL/h while those who received continuous hemodiafiltration (CHDF) had both the dialysis fluid and replenisher solution flow rates set at 400 mL/h. The blood and filtrate flow rates were set at 80 mL.min−1 and 800 mL/h, respectively, depending on the patient.
Blood sampling was conducted seven times in total (before initiation and after termination of TAZ/PIPC administration, at 30 min, and 1, 2, and 4 h after the completion of administration and immediately before the following dose administration). For blood sampling, blood samples each were collected through the blood removal and auto-transfusion dialysis catheter routes, which were defined as the samples before and after filtration, respectively. We also obtained a 3 mL diafiltrate with the blood sampling, and all the samples were frozen at −20°C after the serum was separated. After the linkable anonymizing was applied to the data to ensure that the patients could not be identified, the samples were transferred to the Department of Clinical Pharmacotherapy, Hiroshima University, to measure TAZ/PIPC levels in the blood and diafiltrate by using high-performance liquid chromatography (HPLC).13 Furthermore, acetonitrile and dichloromethane deproteinization was performed on the sample. The HPLC system included a C18 column while the detection was performed at 220 nm with a mobile phase consisting of phosphate buffer (pH 2.6) with acetonitrile (75:25 and 95:5, PIPC and TAZ, respectively). The determination limit was 0.5 and 1 μg/mL for PIPC and TAZ, respectively. For intra- and interday measurement, the precision was 0.69%–7.24% (PIPC) and 1.10%–9.49% (TAZ), and the accuracy was 99.6%–107% (PIPC) and 97.5%–112% (TAZ).
We used a one-compartment model to characterize and parameterize the PK of TAZ/PIPC, because semilogarithmic plots showed that their blood levels were eliminated mono-exponentially. The t1/2 was calculated using the elimination rate constant (kel) as follows: t1/2 = ln 2/kel. The AUC was calculated using the trapezoid summation after binding the overtime plasma concentration values with a straight line. The CLtot and the Vd were calculated as follows: CLtot = intravenous (IV) dose/AUC and Vd = C0/IV dose.
Table 1 shows the patient characteristics, and the common infections leading to the administration of TAZ/PIPC were pneumonia, bacteremia, peritonitis, and cholecystitis. The pathogenic bacteria, which were acquired during empiric therapy in some patients, were Enterococcus faecium, Klebsiella pneumoniae, Acinetobacter baumannii, and Bacteroides ovatus. TAZ/PIPC was used as the first dose in only one patient in the 2.25 g twice daily group while nine received it 3–7 days later. For the CRRT, the CHDF, and CHD modalities were used in eight and two patients, respectively. The CRRT was introduced based on renal indications associated with septic acute kidney injury in all the patients.
Both the blood urea nitrogen (BUN) and creatinine (Cre) levels were elevated in all the patients (2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups; BUN and Cre, 59±29 and 3.09±1.36, 48±27 and 2.27±0.68, and 128 and 4.8 mg/dL, respectively). The creatinine clearance rate (Ccr) calculated using the Cockcroft–Gault formula was 18.9±6.9, 23.7±5.6, and 11.5 mL.min−1 in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively. Six patients developed liver damage and showed increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (AST/ALT 151±174/156±286, 84±53/132±108, and 23/8 U/L in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively).
Figures 1 and and22 show the changes in the blood levels of PIPC and TAZ. Tables 2 and and33 show the PK parameters of PIPC and TAZ. The CLtot of PIPC was 2.57±0.63, 2.06±0.58, and 2.2 L/h in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively, which indicated that it was reduced by 14%–19% compared to that revealed by the data of the healthy adults. We referred to the data which six Japanese healthy male volunteers received TAZ/PIPC 4.5 g four times a day.12 The CLtot of PIPC in healthy adults was 13.5 L/h. The t1/2 of PIPC was 11.4±5.5, 10.7±2.0, and 6.9 h in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively, which indicated that it was prolonged 7–11 times more than that of the healthy adults. The t1/2 of PIPC in the healthy adults was 0.99 h. The CLtot of TAZ was 2.01±0.58, 1.86±0.48, and 2.51 in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively, which indicated that the clearance was reduced by 14%–19% compared to that shown by the data of the healthy adults. The CLtot of TAZ in healthy adults was 13.0 L/h. The t1/2 of TAZ was 12.9±7.1, 16.1±4.9, and 7.6 h in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively, which indicated that it was prolonged 9–19 times more than that of the healthy adults. The t1/2 of TAZ in the healthy adults was 0.84 h.
The drug clearance (CLtot) of PIPC and TAZ was correlated with the blood flow and the amount of blood purification.14 Compared to similar studies performed in other countries, a study by Seyler et al,7 using TAZ/PIPC on a 4.5 g four times daily dosage regimen, reported that the blood flow was set at 150 mL/h, which was higher than that of our study (the blood flow of our study was 80 mL/h). The amount of blood purification was 45 mL.min−1, which was higher than that of our study (the amount of blood purification of our study was 13.3 mL.min−1). In their report, the t1/2 of PIPC was significantly lower (4.16 h) than that of our study (11.4, 10.7, and 7.6 h in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively). The CLtot value of PIPC reported by Seyler et al showed a higher value (4.14 L/h) than that of all the groups in our study (2.57, 2.06, and 2.2 L/h in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively). The modality setting for CRRT in foreign countries tends to be higher for both blood flow and blood purification than what is used in Japan. Therefore, the t1/2 of the drugs tends to be prolonged and the CLtot tends to be reduced in Japan.
In addition, the theoretical value of the drug clearance rates during CRRT (CLCRRT) can be calculated as follows: CLCRRT = sieving coefficient (Sc) × dialysis waste fluid flow. The CLCRRT of PIPC was determined to be 0.77±0.23, 0.63±0.08, and 0.59 L/h in the 2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups, respectively. Because of the analysis used in our study, these values were relatively lower than the CLtot was; therefore, the rate of removal of the drugs with CRRT was low. Thus, in the CRRT modality used in Japan, we think that increasing the quantity and additional dosage of TAZ/PIPC is not necessary.
TAZ/PIPC is an antibiotic combination consisting of a beta-lactamase inhibitor and penicillin in a 1:8 ratio. TAZ inactivates the beta-lactamase produced by bacteria, which protects PIPC from being degraded by beta-lactamase. Therefore, it exhibits an antibacterial action against PIPC-resistant bacteria. PIPC shows antibacterial activity by inhibiting bacterial cell wall synthesis. For the combination therapy, a ratio of TAZ:PIPC ranging from 1:8 to 2:1 is thought to provide excellent therapeutic effect, and the ratio of the blood level is maintained at 1:8 to 1:9 without remarkable change.15 Thus, no change in efficacy is anticipated by the changed ratio.
Pseudomonas aeruginosa is considered to exhibit the following characteristics: half-maximal (50%) minimal inhibitory concentration (MIC50) and MIC90 of 8 and 128 μg/mL, respectively.16 The antibacterial effects of beta-lactam derivative antibiotics are known to correlate with the time above MIC (TAM), which suggest that the blood level exceeds the MIC.17 An indication that penicillin antibiotics provide a maximal antibacterial effect is thought to be the achievement of a TAM rate of ≥50%.18 In our study, the TAM% of the bacteria, with an assumed MIC of 8 μg/mL, was 100% in all the groups (2.25 g twice daily, 2.25 g three times daily, and 4.5 g twice daily groups). The MIC, which met the condition requiring that the TAM achieved ≥50%, was 32 μg/mL (Table 4).
A blood level of 2.5–5.0 μg/mL, which is maintained continuously for 1–2 h, is necessary to ensure that TAZ provides beta-lactamase inhibitory effects.15 In our study, all the subjects maintained TAZ blood levels at 2.5 μg/mL. Consequently, even in the 2.25 g twice daily group, which received the lowest drug dose of all the study groups, the beta-lactamase inhibitory effects of TAZ exhibited the maximal antibacterial effect of penicillin antibiotics against bacteria with a MIC value of 32 μg/mL.
Our study revealed that TAZ/PIPC showed a prolonged t1/2 in the 2.25 g twice daily group and a reduced clearance rate that maintained the blood levels. In the pharmacodynamic analysis, the antibacterial effects of the drug with a MIC value of 32 μg/mL can be expected. Therefore, the 2.25 g twice daily regimen can be considered appropriate for the common modality setting of CRRT used in Japan, which consists of a continuous venovenous hemodiafiltration blood flow of 80 mL.min−1 and blood purification amount of 10–16 mL·kg−1·h−1. However, clearance mediated by the residual renal function is thought to occur in patients who underwent CRRT for non-renal indications, and in such cases, it would be necessary to exercise caution to avoid incidences of under dosing.
Drug metabolism during CRRT is known to be influenced by the percentage liver metabolism exhibited by a patient. In addition, in such situations, the liver metabolism was greatly influenced by various factors, including the liver and residual renal function, tubular secretion,19 and removal of drugs by blood purification of the patient. In our study, the residual renal function was remarkably low, and the rate of drug removal by blood purification was low because the targeted drugs were largely renally excreted, and the criteria for initiating CRRT were renal indication. Therefore, we concluded that the drug concentration was maintained at a lower dose than was expected.
We have to state a limitation of this study. The number of investigations was 10. They are very small, and it may be insufficient to assert that 2.25 g twice a day as the dosage of TAZ/PIPC during CRRT is the most appropriate. But we think that just because CRRT is performed does not mean we have to increase the amount and time of dosage of the medicine.
Considering that the common modality setting of TAZ/PIPC administration during CRRT in Japan uses a dosage of 2.25 g twice daily where the blood levels are maintained, we propose that the dose and frequency are appropriate, based on the outcome of this study.
The authors report no conflicts of interest in this work.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Doctor insights on:
Natural Treatment For Hiatal Hernia
What is success of laparoscopic anti-reflux surgery for hiatal hernia?
Varies: Don't be afraid to ask your surgeon. Most surgeons track their outcomes for at least a few years. If you go to a surgeon with good results and you do your part (eating right and keeping your weight in check) - you can expect durable relief with surgery. ...Read moreSee 2 more doctor answers
Upper Abdomen (Definition)
Draw a transverse line through the umbilicus and the upper abdomen includes every part of the belly above this line and below the ...Read more
Which treatments are needed for a hiatal hernia?
Life style changes: Most hiatal hernias need no treatment. It is best to remain upright for at least 4 hours following meals, avoid smoking and drinking alchol, try not to drink liquids prior to lying down. ...Read moreSee 1 more doctor answer
Is there a cure for hiatal hernia?
YES: As with any hernia, it can be surgically repaired. ...Read moreSee 2 more doctor answers
Suggestions on pharm treatment for soa secondary to hiatal hernia?
Several: Reduce reflux: elevate head of bed. Small meals and not late into evening before sleep. No smoking control weight then antacids, blockers etc. ...Read more
What is holistic treatment for an inguinal hernia?
None: No professionally accepted " holistic treatment for inguinal hernia " is available except wearing a truss as a temporary means. Surgery is only way to prevent complications. ...Read moreSee 2 more doctor answers
Is a hiatal hernia repair effective?
Yes : Of course there area many factors to consider, but most importantly is what the goals of the repair are - resolution of symptoms or prevention from getting worse or both. In general, hiatal hernia repair should have a 90-95% success rate. ...Read moreSee 2 more doctor answers
Is there a holistic treatment for an inguinal hernia?
No: Once you have developed a hernia which is a defect in the abdominal wall it will be there till it is repaired. Some patients get relief from the use of trusses for wide based-direct type inguinal hernias( esp in the elderly).Some also get support from abdominal binders for wide-mouthed hernias ...Read moreSee 2 more doctor answers
Is the mesh treatment for incisional hernia safe to do?
Yes: There are however many different clinical scenarios, including the size and location of the hernia that will dictate the technique of repair which in turn will dictate the type of mesh that is best for you. ...Read moreSee 2 more doctor answers
Can you tell me about laparoscopic anti reflux surgery for heartburn and or hiatal hernia?
Laparoscopy: In general terms, the operation uses 5 small incisions, takes 2-4 hours depending on a variety if factors, is associated with a 1-2 night stay in the hospital, and a 1-2 week recovery period regarding postop pain. There is usually difficulty swallowing for 3-6 weeks afterward as well. Preop tests will determine if its right for you, and there will be occasional reflux afterward, but markedly improved. ...Read moreSee 1 more doctor answer
What is the recovery like for hiatal hernia surgery?
Week: If done laparoscopically or robotic as i do, you should be back to work in about a week. About 2-3 weeks to feel you can eat all foods. As i tell my patients, most maor surgery like this will put a toll in your lifestyle for about 4 weeks. ...Read moreSee 1 more doctor answer
What skin prep solution is used for a laparoscopic ventral hernia repair?
It depends: There are many skin preps in the market. Each hospital and surgery centers will pick a prep that is recommended by the infection control and surgical societies. Some patients are allergic to some of the preps, restricts the use of certain preps. The most use are alcohol base, and iodine base. ...Read more
Is there an operation for condition of a hiatus hernia and reflux?
YES: Yes there is a surgery. It involves fixing the hernia ( closing the hital opening back to normal size ) and anchoring the stomach in the abdominal cavity so it is less likely to recur. The reflux portion of the surgery is to prevent stomach contents like acid from getting in the esophagus. This can be a complex operation so be sure to talk to your dr about it and the possible complications. ...Read more
Hiatal hernia treatments. Any non-surgical advice to ease this painful condition?
Acid reflux: Stomach acid refluxing back into esophagus is painful. So avoiding acid stimulation and overfilling your stomach will help. Alcohol, and tobacco drive acid production. Also avoid large fatty meals, carbonated beverages, and lying down after eating (stay upright for 2 hours). Check in with your doc to consider anti acid medication and referral for scoping/egd. Tums, (calcium carbonate) over the counter, work well. ...Read more
What's a good diet after tif procedure and hiatal hernia repair?
As tolerated : It's unclear why you would have a tif procedure and a hiatal hernia repair instead of the standard fundoplication and hernia repair, but either way, your diet should be as tolerated. If the food or beverage are difficult to swallow, or make gerd symtoms worse, avoid that in the future. ...Read moreSee 2 more doctor answers
Hiatal hernia is there surgery for it.?
Yes: There are a variety of types and sizes of hiatal hernia. Just because a person has one does not necessarily indicate a need for surgery. Medications and avoidance of eating late at night are some options, a gastroenterologist or your family doctor can help you determine if surgery is your best option, and refer you to a properly trained surgeon if indicated. ...Read moreSee 2 more doctor answers
Which type of exercises are okay for post inguinal hernia surgery for a woman?
Light: Light activity and light exercises like walking, swimming, light stairs or treadmill for the first 4-6 weeks. Check with your surgeon as to when you can return to all normal activities and full exercise. ...Read more
Anyone done laparoscopic anti-reflux surgery for hiatal hernia?
Relatively common: The most common anti-reflux procedure is called a fundoplication, which involves closure of the hernia and re-creating a new valve by wrapping a portion of the stomach around the esophagus. While very effective, this procedure is reserved for the rare patient who cannot manage their symptoms with lifestyle and dietary modifications supplemented by anti-acid medication. ...Read moreSee 3 more doctor answers
How might treating a recurrent inguinal hernia differ from treating a first hernia? Are there specialist for treating recurrent hernias?
Alternate approach: Any hernia can recur. Open and laparoscopic repairs of groin hernias have about a 1% recurrence rate, and umbilical hernia with graft supplement have about a 0.3% rate. Now, in groin hernias, when recurrent , if done open the first time, a laparoscopic approach is preferred in the rerepair, and vice-versa.There are surgeons who have more experience with complex and recurrent hernias. Good luck. ...Read moreSee 1 more doctor answer
Best non surgical treatment for zenker diverticulum?
None: Really, the treatment for this congenital esophagus outpouching is surgical. There's no medication or lifestyle change which can make it go away. Good luck. ...Read more
Are there any natural cures for a abdominal hernia?
No: Surgery is the only treatment for hernia. ...Read moreSee 2 more doctor answers
Hernia (Definition)
The ascendence of the gastroesophageal junction into the chest above the diaphragm through the ...Read more
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Ratings based on 384 Verified Reviews
4.5 Room cleanliness
4.4 Service & staff
4.4 Room comfort
4.5 Hotel condition
Expedia Verified Reviews
for Everyoneby A verified traveler
Posted Sep 13, 2017
Cons: Better lighting in the bathroom to apply makeup.
Very nice and clean. Friendly staff. Offered to give cab info and directions.
for Everyoneby A verified traveler
Posted Aug 23, 2017
We had a long drive behind us and more to go. Happy to stay at this hotel, friendly staff.
by A verified traveler from Orlando, FL
Beautiful lobby, the niceness ends therePosted Aug 23, 2017
The lobby and dining area is absolutely wonderful. Sadly that's as good as it gets. The rooms were just barely ok. Certainly wasn't the worst hotel I've ever stayed at, but was certainly my least favorite of any Holiday Inn Express I've stayed at. Everything was clean, though the beds were quite uncomfortable compared to similarly classed hotels. A front desk mix up led to another guest being issued a key to my room and gaining entry. Be sure to latch your door if you stay here. Breakfast is subpar compared to any class of hotel.
by A verified traveler
Needing a good vacuumPosted Jul 17, 2017
Not knowing that there were rooms and suites- as we were given a suite on our first stay- we asked for a suite when they gave us a room... this seemed to be very confusing for the front desk clerk. It took too long and we were exhausted so we told her to forget it. Whole place looked like it hadn't been vacuumed in a week. Hair in bathroom and funky stuff not wiped off a wall. Looks like their cleaning staff needs training or more folks. Breakfast has many options but powdered eggs must go! So gross...
by A verified traveler
Okay for one night stayPosted Jul 12, 2017
Pros: Location
Cons: Breakfast was okay with not many choices. Kitchen staff was rude and not accommodating. Had to change rooms due to a smell.
Location: It is located in a convenient location.
Check in was smooth, convenient location with lots to eat around. Okay for one night stay on the way to South Utah.
for Everyoneby A verified traveler
Exceeded expectations!Posted Jul 10, 2017
Great personal, customer service. Room was extremely clean and well stocked with more amenities then I expected. Great location near shopping and restaurants! Hotel was well staffed, and clean. Breakfast was great with lots of selections.
for Everyoneby A verified traveler
Love this placePosted Jul 3, 2017
Pros: Everything!
Cons: Pancake machine didn't work one morning, had to ask for a couple things to be restocked at breakfast too.
Location: Great location, not too busy, but restaurants and gas stations close by. Plenty to do in Provo, Lehi, Orem!
Great Hotel. Clean, Comfortable bed, Nice Atmosphere, Good Location, Great Breakfast, Friendly Staff.
for Everyoneby A verified traveler from california
Nice and cleanPosted Jun 29, 2017
Pleasant stay. Loved close to freeway, clean. Nice and professional employees. I would definitely return for a stay
by Joseph
Posted Jun 24, 2017 on Hotels
for Everyoneby A verified traveler
UVU Soccer ID campPosted Jun 5, 2017
I flew my wife and son into Salt Lake City in order to get to Orem, Utah from Texas. The flight, rental car, and hotel were perfect according to my wife! Well done EXP!


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text: FRAPRU chides Charest The Gazette, Montrel, November 13, 2003 Premier attends Alberta benefit while Quebec homeless left in cold. Kevin Dougherty Gazette Quebec Bureau Quebec – Housing advocate François Saillant said yesterday it is « paradoxical » that Premier Jean Charest flew to Calgary last night to roast Alberta Premier Ralplh Klein at a $175-a-plate benefit for Alberta's homeless when a leaked report indicates Charest has no money for Quebec's homeless. « It's all very well that he is going to Calgary for the homeless benefit, but he isn't looking after his own backyard, » Saillant said, noting the Charest government's action plan to fight poverty has laudable intentions, but no means to follow through on its stated goal to help itinerants. Saillant noted that a shelter in Gatineau, with room for 24 homeless people, is completed but stands empty because there is no money to hire social workers. « It isn't very reassuring for the homeless here that he is hanging around with Ralph Klein, » said Saillant, who heads the group FRAPRU, Front d'action populaire en réaménagement urbain. In December 2001, on his way home from a Christmas party, Klein made an after-midnight visit to an Edmonton homeless shelter, where he got into a shouting match with a resident. Shortly after the incident, Klein admitted he has an alcohol problem. Rion Sillito, spokesperson for the Calgary Homeless Foundation, explained that last night's event would be the fifth time Klein has been roasted for the homeless. Last year, the Klein roast raised $100,000 for homeless shelters in Calgary. This year's event will gross $225,000, Sillito said. Saillant noted that the Parti Québécois government proposed $128 million more for public housing and the homeless in its budget last March. The Liberals' action plan to fight poverty, which FRAPRU has obtained, proposes no additional funding, leaving Saillant wondering how a promised 13,000 new units will be built. firstname.lastname@example.com _________________________________________________________________ MSN Search, le moteur de recherche qui pense comme vous ! http://fr.ca.search.msn.com/


text: Terzes Photography [ Grand Rapids Symphony Opens Their New Season This Weekend By Andy Rent 5 days ago Grand Rapids Symphony opens new season with a bang! Read More Category: Andy Rent, Concerts, entertainment news, Events, Grand Rapids Events, Grand Rapids News, Music News Tags: bolero, de vos performance hall, grand rapids symphony, grso, Marcelo Lehninger, ravel, Sarah Chang Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Guide from MoversCorp to what to look out for when shopping for a mover. What you should compare and pay attention to before selecting a local moving company.
Compare and Hire a Mover
When it comes to selecting an option for out of state or country move, there are several options. However, there are benefits and drawbacks with each choice. Find out how mobile containers make moving easier.
Moving Containers
You load we drive is another do-it-yourself moving option. Transportation company delivers a container or trailer and you do the actual labor; loading and unloading your possessions.
You Load We Drive Service
Each household item requires different types of packaging. This guide will help you to pack and transport heavy items.
How to Pack Heavy Items
We all have items that we don't have a use for. The question is, what we should do with these items when we move? Can we get something back in return? This guide will show you how to sell your unwanted items and save on your move.
How to Dispose of Appliances and Electronics
Moving yourself is not easy and it takes a lot of hard work and commitment. We have prepared some funny moving tips to cheer you up.
DIY Moving Tips
Moving companies in Palmerdale, Alabama - Local Movers


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Crimestoppers of Greater New Orleans will have five minutes of community prayer against violence Aug. 22 from 12:30-12:35 p.m. Forty-five Catholic churches will ring
Tag: prayer
Men sometimes feel awkward offering a prayer
When teachers and administrators at Loyola's Summer Institute for Catholic Educational Leadership compared notes on the topic of "male spirituality," they discovered that many Catholic men tended to use the same formula when asked to lead a group of their fellow men in prayer:
St. Pius X has hosted Thursday group for 40 years
While in Texas with her husband as he was receiving care for a serious illness, a member of St. Pius X Church's weekly prayer group admitted she often would be at her "wit's end" despite having a rich prayer life and the support of her children.
Value of life confirmed in letter on human trafficking
December 5, 2012 To: Clergy, Religious, and Laity of the Archdiocese of New Orleans Dear Sisters and Brothers in Christ: Once again, our
Charity, social justice must be couple with prayer
All pastoral work, including promoting social justice and providing for the poor, must be nourished by prayer, Pope Benedict XVI said. Without


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A WOMAN has revealed how she sounded like she had drunk "too many glasses of wine" after a rare condition left her face paralysed.
Emmeline Stephenson, 27, thought she had had a stroke and was forced to tape her eyes closed so she could sleep as the condition slowly made it harder for her to move her face.
She has repeatedly been struck by Bell's palsy – a condition with alarming symptoms including weakness or paralysis on one side of the face, a drooping mouth and difficulty shutting the eyelids.
Sufferers can also drool and slur and the paralysis makes eating and drinking difficult.
Now Emmeline, has released pictures of herself to raise awareness of the condition and revealed how she sounded drunk when the condition struck.
She said: "My speech was slurred, like I'd had one too many glasses of wine and people would ask me if everything was OK, it was so embarrassing."
Special needs support worker, Emmeline, of Hull, first developed the illness – understood to be caused by a virus – while studying broadcast journalism at Leeds Met University in West Yorkshire in 2010.
Horrified, when she woke up and saw her wonky face in the mirror, she assumed she had suffered a stroke.
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She said: "I woke up and had a drink, which was difficult to swallow.
"But it was only when I went to brush my teeth that I saw my face was all saggy on my left-side.
"I really thought I'd had a stroke, it was scary."
Calling her grandmother, Naomi Stephenson, 74, who brought her up, she told Emmeline to contact the NHS non-emergency number, where medics told her it sounded like Bell's palsy, not a stoke.
Seeing her GP three days later, she was prescribed steroids to strengthen her muscles so she can move her face more.
They eventually worked, but in the meantime, Emmeline was desperately embarrassed by her appearance.
She said: "I felt really ashamed about my face.
"People asked me if I'd had a stroke, or if I was okay and it really affected my self-esteem.
"I know it's just a face, but it is one part of you that you can't change and I felt really bad about it."
Emmeline even tried to hide inside, covering her face with a scarf and sunglasses if she ventured out.
But the effects of the Bell's palsy were not purely cosmetic.
In order to sleep, Emmeline had to tape her left eye shut, as it was stuck wide open.
Finally, after two months, the condition gradually disappeared.
But it struck again in December last year, while she was working with a pupil at school.
She continued: "It was the last day of term before Christmas. After break-time I was working with a pupil, who said, 'Miss, are you chewing gum?'
"I told him I wasn't, but then a colleague came over and also said my face was looking strange.
"I knew straight away that the Bell's palsy was back."
Bell's palsy is a condition that causes temporary weakness or paralysis of the muscles in one side of the face.
It is the most common cause of facial paralysis.
Bell's palsy is believed to occur when the nerve that controls the muscles in your face becomes compressed.
The exact cause is unknown, although it's thought to be because the facial nerve becomes inflamed, possibly due to a viral infection.
The symptoms of Bell's palsy vary from person to person.
The weakness on one side of the face can be described as either:
- partial palsy, which is mild muscle weakness
- complete palsy, which is no movement at all – although this is very rare
Around seven out of 10 people with Bell's palsy make a complete recovery, with or without treatment.
Most people notice an improvement in their symptoms after about two to three weeks but a complete recovery can take up to nine months.
The recovery time varies from person to person and will depend on the amount of nerve damage.
A GP may provide steroid treatment to strengthen the muscles in the face.
Any one who suddenly develops facial paralysis should call 999.
Looking in the mirror in the staff toilets, Emmeline saw that her face was, once more, wonky on the left side.
She recalled: "I was still able to talk, but sounded like my mouth was full on one side.
"Just like before, it was a slurring sound, like I was drunk."
Calling the doctor, she got an appointment the next day and was again prescribed steroids, given physiotherapy at her GP's surgery, including facial exercises, to get her body back to normal.
She added: "Using my face to communicate with the students is a big part of my job, but I was determined not to let Bell's palsy get on top of me this time.
"Even though I didn't look like me, I decided to take a picture of myself, desperately trying to straighten out my face. Then I posted it on Instagram and shared my journey with the world.
"Seven years ago, when it first happened, I didn't want to leave the house, but this time I really want to get on with my life."
Emmeline continued to post photos of herself on the social media site, and has had a great reaction from others who have had the condition too.
She said: "It did make strangers feel uncomfortable.
"They would stare, but did not dare ask me what was wrong.
"Now I want to help change that and for more people to know about Bell's palsy."
The NHS recommends that people with facial weakness or paralysis call 999.
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text:
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Yee yee! We've found 17 lyrics, 5 artists, and 8 albums matching rank by mr oizo.
Mr. Oizo · Rank 1 · Dicky Rank · Rank and File · Rank Nubah
Complete Faith: HMV, Top Rank and Parlophone Recordings 1958-1968 (Adam Faith) · Rank (The Smiths) · Top Rank Explosion (Hutchinson, Hutch) · Rank (The Smiths) · Top Rank Story 1962 (Hutchinson, Hutch) · Rank (The Smiths) · Rank (The Smiths) · Rank & File (Mark Germino)
meaning, hey Man, a bad man and man, nuh mingle wid nuh rodman And if yuh dis di program, yuh is a dead man Either by a shot or yuh hang Jah, Jah ranks
though we ain't got hats or badges We're a union just by sayin' so And the world will know What's it gonna take to stop the wagons? Are we ready?
By Michael Brown Oh, we're meetin' at the courthouse at eight o'clock tonight You just walk in the door and take the first turn to the right Be
vision No warm welcome for mother and son Just The rank smell of ass-crack, funk, and cum But Mommy's prayerful strength-her best defense She,
featuring be -Real [Mr. Duke] I told the tower of power we can work together But I guess they rather see wars and scars better
and measure planets by parallax Check out the retrograde motion, kill the notion Of biting and recycling and calling it your own creation I feel like Rockwell,
Uhh Uhh Uhh Uhh Uhh I told ya I'm the colonel of this muthafuckin' tank Don't make me get rowdy and start pullin rank My comrads with tanks
Knowhatimsayin? I feel you my nigga Catchin 45s, being chased by the government, shit like that I'm diggin it Bitches you know, mindscapin, tryin to set a nigga
vision No warm welcome for mother and son Just The rank smell of ass-crack, funk, and cum But Mommy's prayerful strength-her best defense She,
them baggin grams I'm a bad man Strap in my hand Give me some mad plans Picture my city Surrounded by crimnals And then some I'm go have to hit one
are the sexiest man Mr. Jin, I love the way you do your things [Jin] The moral of the story is Don't judge a book by its cover I know you think
are the sexiest man Mr. Jin, I love the way you do your things [Jin] The moral of the story is Don't judge a book by its cover I know you think
Who you foolin.. only foolin (2X) [Dove] Yo, I stay cousin to this, introducing Mr. Dave Banner Scannin proper with my sight muscle This rap
It's Mr. Ski, The West Coast Kill-A-Bitch [Chorus] [Kam] Niggas hate me for the bank I'm foldin' The rank I'm holdin' The dank I'm polin' They
back with Ski While he blast with his back to me West Coast drive-by, it happens like everyday Bitch ass mothafuckas gettin' chased away It go
in beautiful technicolor Directly from another place you could expect no other To stand by these trues and break these rules We defy the laws of cool
more Mr. Nice Guy, excuses be given but that's how you MADE me Bitch this real life, it ain'ts to be played with One false move, niggaz I tear


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The U.S. Department of Justice said in a letter to U.S. Rep. Vern Buchanan, R-Fla., that victims of fraudster Bernie Madoff would begin to receive payouts from the department's Assets Forfeiture Fund by the end of the year, the congressman announced ...read more
Manhattan federal prosecutors on Tuesday said a jury deciding if Platinum Partners LP's founder bribed a union official for investments should hear evidence that Platinum's principal fund was losing investors at the time. ...read more
A government financial crimes watchdog on Wednesday warned U.S. banks to be on the lookout for attempts by Venezuelan government officials to funnel illicit funds into American real estate and other markets. ...read more
Federal Reserve Chair Janet Yellen on Wednesday warned that the central bank was looking closely at taking actions against Wells Fargo & Co. for its "egregious and unacceptable" sales practices and other problems. ...read more
The directors of fertility treatment developer OvaScience Inc. on Tuesday asked a Delaware federal judge to transfer a derivative action filed in the First State to Massachusetts, where the company is headquartered and where similar suits over excessive ...read more
The trustee for Bernie Madoff's defunct investment firm can proceed with a suit that seeks to clawback $2.2 million withdrawn by an investor before the $65 billion Ponzi scheme imploded, a New York bankruptcy court ruled on Wednesday. ...read more
The former CEO of a fiber optics company that was bought by Corning Inc. last year was criminally charged and sued by the U.S. Securities and Exchange Commission on Wednesday for allegedly using insider information and secret brokerage accounts to make ...read more
A New Jersey federal judge Monday found the dissolution of the original policyholder in a merger did not relieve Progressive Casualty Insurance Co. of the duty to defend the post-merger bank from a stockholder suit. ...read more
Five lawyers are soon joining forces to open a boutique law firm — Tiber Hudson LLC — that will have offices in New York City and Washington, D.C., and will focus on real estate, securities, government contracts and banking, among other areas, one of ...read more
A New York federal judge gave European investment firm KBC Asset Management NV and its lawyers at Motley Rice LLC the green light on Tuesday to lead a proposed securities fraud class action against cloud computing company Rackspace Hosting Inc. ...read more
A New York state court's recent decision in LNYC Loft v. Hudson Opportunity Fund regarding the authority of a limited liability company to appoint a special litigation committee represents a departure in the trend of courts using statutory and common ...read more
The Delaware Chancery Court's opinion in Morris v. Spectra Energy provides a road map for the litigation of safe-harbor provisions in limited partnership agreements and invites close review by both private fund litigators and drafters of Delaware ...read more
A decision on the equivalence of securities and derivatives markets regulation in the U.S. and the European Union could be finalized in the next few months after intense negotiations between regulators on both sides of the Atlantic, a senior EU official ...read more
Marathon Oil told a Texas federal court Tuesday that it has agreed to pay a group of limited partners $33.1 million to settle claims that the company cheated them out of millions in foreign tax credits in connection with a gas processing plant in Equatorial ...read more
Imagine going to a restaurant and ordering your steak medium-rare. The steak arrives burned. You expect the kitchen to bring you another one properly done, right? And you don't expect to pay for two steaks, do you? Paying a vendor for document review ...read more
The European Securities and Markets Authority will be handed a greater role in market abuse investigations under European Union plans to make the watchdog the direct supervisor for a range of capital markets, the bloc's head of financial services ...read more
The rash of investigations launched in the wake of Equifax's massive data breach signal a more open and aggressive approach to policing such incidents that is likely to leave companies rethinking their plans for responding to cyberattacks and cooperating ...read more
The U.S. Commodity Futures Trading Commission recently told a private university that it does not need to register as a commodity pool operator or commodity trading adviser, agreeing that limiting the regulatory risk of the university's billion ...read more
A New York federal judge on Tuesday sentenced a former attorney to 38 months in prison for scamming four victims out of $1.4 million in purported real estate investments while he was under judicial supervision on three different fraud-related indictments ...read more
Attorneys for the directors of drug maker InSys Therapeutics Inc. told a Delaware state court judge Tuesday that a shareholder derivative suit should be tossed because the board took steps to bolster its compliance programs when issues with the marketing ...read more
Investors suing the company behind online foreign exchange broker FXCM for securities fraud have shot back at the company's bid to dismiss their consolidated class action complaint, telling a New York federal court on Monday that they have "more ...read more
A proposed class of investors accusing Snapchat maker Snap Inc. of misleading them about the app's user growth will be led by Kessler Topaz Meltzer & Check LLP in a securities fraud suit that was consolidated by a California federal judge on Monday ...read more
A New York federal judge on Tuesday ruled that European telecommunications company Veon Ltd., which admitted to paying bribes in Uzbekistan, can't escape a proposed class action for failing to disclose its crimes to investors, finding that the suit ...read more
Prosecutors in the felony securities fraud case against Texas Attorney General Ken Paxton on Tuesday asked the state's highest criminal court to enforce a trial judge's order they should be paid $300 an hour for their work, saying a lower ...read more
AOL Inc. attorneys argued Tuesday for a 10.3 percent lower payment to stockholders who challenged the $50 per share terms of AOL's sale to Verizon Communications Inc. in 2015, during a final round of arguments in a Delaware Chancery Court stock ...read more


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ALL >> Business >> View Article
Company Control Details You Simply Will Not Locate Somewhere Else
Total Articles: 9
On the planet of business, genuinely great control can be a wonderful thing to behold. But, not every person understands what must be done to steer others or get the most from other people's potential. This content that follows gives some terrific ideas about authority which will help almost anyone get good results in this particular world.
Use a mentor. Find a person in whose authority abilities you rely on, and model your habits following their own. See them for a while, and have a concept of the direction they direct and the thing that makes them an excellent director. You don't would like to mimic them fully, but find what functions with regards to their design and combine it in a design that works for you.
When trying to become a great leader, you should tune in to how many other people have to mention. Your thoughts or suggestions aren't certain to be excellent just because you're a leader. When you tune in to other ideas or thoughts, you will probably find that the people close to could also have wonderful ideas that could work efficiently with yours.
Walk the talk. Frontrunners don't say something and do one more. That is certainly perplexing to staff members, and demotivating often. Alternatively stay by what you say. Follow-through and direct by example. Then you'll acquire more than staff, you'll have champions who have faith in your company as well as your authority also.
In no way belittle your coworkers. Your subordinates will in no way admiration you if you do not take care of all of them with respect. Keep in mind that you will be not much better than they can be. Look at oneself blessed to become head. Handling your colleagues as you would want to be handled will go a long way in developing a supportive crew.
A great innovator, or supervisor, will go out of her or his method to get to learn workers far better. Not just about work-connected subject areas, but regarding their outside the house routines, household and pursuits. Employees take pleasure in it when their executives accept them in such a way that don't relate to operate. This may cause the partnership a tad bit more individual.
Take care of all of your current employees properly and never get involved with office gossip. Personnel are normally more happy in a surroundings where their job is loved and valued on the same level just like any other personnel. Spend time dealing with all of your current staff so that you comprehend every single person's involvement.
Learn how to be responsible for things, even individuals which are not your wrong doing. An excellent leader realizes that once the group falters, everyone fails. As an alternative to setting fault on specific individuals the team, a fantastic head are fully aware of that anything concerning the way he qualified prospects the group could be the reason for the failing.
Talk to other executives. This can be a good way to get comments on ideas and to figure out how advisable to street address issues and troubles. This will likely also offer you a chance to discover other control types and methods. You will probably find something valuable, or you might encourage another person.
When it comes to agencies of all kinds, but specifically company enterprises, the existence or absence of robust control can be a make or split undertaking. The real key to displaying wonderful control consists of a comprehensive understanding of essential methods and principles. With a little luck this information has offered sufficient backdrop to foster true accomplishment.
Source: les brown
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