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ILOOP – a web application for two-channel microarray interwoven loop design
IEEE 7th International Conference on Bioinformatics and Bioengineering at Harvard Medical School
IEEE 7th International Conference on Bioinformatics and Bioengineering at Harvard Medical School
Microarray technology is widely applied to address complex scientific questions. However, there remain fundamental issues on how to design experiments to ensure that the resulting data enables robust statistical analysis. Interwoven loop design has several advantages over other designs. However it suffers in the complexity of design. We have implemented an online web application which allows users to find optimal loop designs for two-color microarray experiments. Given a number of conditions (such as treatments or time points) and replicates, the application will find the best possible design of the experiment and output experimental parameters. It is freely available from
Microarray technology is now widely used to address complex scientific questions and for studies of gene interactions. However, it is associated with a number of technical challenges. The high cost of microarrays plus the complex logistical issues associated with microarray studies, often require that compromises must be made in the number of samples analyzed. Replication of data is a fundamental and widely appreciated principle of design that is often sacrificed. Microarray users now acknowledge that "replication" means different things in the microarray context
Certain decisions as to how many microarray slides will be used and which mRNA samples will be hybridized to each slide must be made in preparation of mRNA samples before carrying out a microarray experiment
Figure 1
Combination of varieties with dyes for the reference (A) vs. loop design (B)
Combination of varieties with dyes for the reference (A) vs. loop design (B).
The computation of variance in a loop design depends on the design and the number of samples. In the loop design, each sample is compared directly with other samples in a multiple-pairwise (circular) way. Most studies on microarray design suggest that the loop design of microarray experiments is more efficient than the reference design
In a cDNA microarray experiment, the foreground red and green intensities can be considered as
In loop design, using the optimal weighting, the variance of the contrast between adjacent treatments is
Kerr and Churchill
Figure 2
An example interwoven loop design with 18 arrays and 9 conditions
An example interwoven loop design with 18 arrays and 9 conditions.
Wit et al.
Currently biologists take a considerable amount of time to develop loop designs manually and the final design may not be optimized. To date there is no available tool for biologists to automatically design and visualize the interwoven loop for a microarray experiment. Development of such a tool will permit biologist to quickly generate different array hybridization loops, compare the cost and experiment design and efficiently design microarray studies so that robust statistical conclusion can be made.
Here we calculate the most optimal loop by considering the number of replicates and conditions. The main point is to generate an optimal number of arrays based on combination of conditions and replicates for two-dye microarray experiment.
The web application has been developed using PHP language on an open source Apache web server. It is freely available from
Figure 3
The web application screenshot
The web application screenshot.
Given a number of conditions (treatments/timepoints) and replicates, the program generates the optimal interwoven loop design. The start menu has two drop boxes, one for "Number of Conditions" and another for "Number of Replicates". By selecting the number of conditions and replicates, the application generates an experiment design matrix table (Figure
Figure 4
A screenshot of optimal interwoven loop table and graph
A screenshot of optimal interwoven loop table and graph.
Figure 5
The experiment design matrix table
The experiment design matrix table.
In Figure
As an example figure
We evaluated the utility of the design application using a microarray designed to study the effect of chemical toxicity on earthworm
Figure 6
An interwoven loop hybridization schemes for 4 treatments with 5 independent biological replicates
An interwoven loop hybridization schemes for 4 treatments with 5 independent biological replicates. Circles represent treatment samples. Sample code: 0.x = replicate × of solvent control worms; 1.x = replicate × of 10.6 mg TNT/kg soil treated worms; 2.x = replicate × of 2 mg TNT/kg soil treated worms; 3.x = replicate × of 38.7 mg TNT/kg soil treated worms; x = 1–5. Arrows represent array hybridizations between respective samples where the arrowhead indicates Alexa 647 dye labeling and the base of arrows indicate Cy3 dye labeling.
The hybridization experimental design tool proved simple to use and facilitated execution of the complex sample pairing required by this approach. A similar reference design would require 80 arrays to achieve 5 biological replicates over 4 conditions with 4 technical replicates compared to 40 required arrays in the optimal loop design in this experiment.
The main significance of this paper is introduction of a web application that implements loop design for microarray experiment. To date no online application has been available to achieve this goal. Such designs should be analyzed by treating the arrays as blocks of size 2 and analyzing the channels as individual observations.
Our web application will allow scientists to design and graph the optimal interwoven loop faster. They can quickly select the number of conditions and replicates and weight the number of samples and arrays in order to minimize the cost and complexity of the experiment as well as maximizing the efficiency of the experiment.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
MP and YD initiated the study. MP and YD designed and implemented the application, web server configuration and web application programming. PG and EJP provided the data. MP, YD, PG, and EJP drafted the original manuscript. YD, PG, JY, MY and EJP coordinated and directed the project. All authors have read and approved the final manuscript.
This work was supported by the Mississippi Computational Biology Consortium (NSF EPS-0556308), Army Environmental Quality Program of the US Army Corps of Engineers (under contract #W912HZ-05-P-0145) and the Mississippi Functional Genomics Network (DHHS/NIH/NCRR Grant# 2P20RR016476-04). Permission to publish this information was granted by the Chief of Engineers.
This article has been published as part of
Analysis of variance for gene expression microarray data
Experimental design for gene expression microarrays
Analysis of cDNA microarray images
Defining best practice for microarray analyses in nutrigenomic studies
Fundamentals of experimental design for cDNA microarrays
Statistical adjustment of signal censoring in gene expression experiments
Statistical implications of pooling RNA samples for microarray experiments
Factorial and time course designs for cDNA microarray experiments
An experimental evaluation of a loop versus a reference design for two-channel microarrays
Statistical design and the analysis of gene expression microarray data
Variation in gene expression within and among natural populations
Review of microarray experimental design strategies for genetical genomics studies
Design of microarray experiments for genetical genomics studies
Assessing statistical precision, power, and robustness of alternative experimental designs for two color microarray platforms based on mixed effects models
Optimal cDNA microarray design using expressed sequence tags for organisms with limited genomic information
Marine genomics: a clearing-house for genomic and transcriptomic data of marine organisms
Extending the loop design for two-channel microarray experiments
Experimental design and low-level analysis of microarray data
Efficient two-sample designs for microarray experiments with biological replications
Design of large time-course microarray experiments with two channels
Statistical tests for differential expression in cDNA microarray experiments
Toxicogenomic analysis provides new insights into molecular mechanisms of the sublethal toxicity of 2,4,6-trinitrotoluene in Eisenia fetida


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|Liberty County Government Page
Visit the government page for Liberty County to access agencies, departments, officials, notices, news, services, and more.
|Property | CAD
Liberty County Appraisal District real and personal property records. Address: Liberty CAD, 2030 Sam Houston, Liberty, TX 77575-4818. Phone: 936-336-5722.
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1983 - The Company was Incorporated on 8th November, at Hyderabad.
- The Company's object is to manufacture glazed and unglazed
ceramic tiles for floors and walls.
- The Company was promoted by G.N. Naidu, K. Seshagiri Rao, and
P.G. Naidu. The Andhra Pradesh Industrial Development
Corporation, Ltd. (APIDC), the Pondicherry Industrial Development
& Investment Corporation, Ltd. (PIPDIC) and Welko Industrial SpA
of Italy (Welko) also participated in the equity capital of the
- The Company entered into a foreign collaboration agreement with
Welco Industriale SpA of Italy (Welko) for supply of know-how,
engineering and also for the supply of plant and machinery.
Welko were to be paid US $ 3,90,000 for the technical know-how
and US $ 5,040,100 as CIF value for supply of plant and
1985 - 5,40,000 No. of equity shares taken up as follows:
- (i) 1,50,000 shares by APIDC.
- (ii) 3,40,000 shares by directors and their associates and
- (iii) 50,000 shares by PIPDIC. 34,80,000 shares then issued at
par of which 15,00,000 shares were reserved and allotted as
- (i) 2,50,000 shares to promoters
- (ii) 10,00,000 shares to WELKO,
- (iii) 1,50,000 shares to APIDC and
- (iv) 1,50,000 shares to APIDC and
- (v) 1,00,000 shares to PIPDC.
- Out of the balance of 18,60,000 shares, 8,39,200 shares reserved
and allotted on a preferential basis as follows:
- (i) 6,00,000 shares to NRIs;
- (ii) 39,200 shares to friends and associates of promoters,
directors etc. and
- (iii) 2,00,000 shares to employees of the Company. The remaining
11,20,000 shares offered to the public in December (all were
taken up). 30,000 shares pending allotment.
1986 - The Company undertook to set up a project for the manufacture of
25,000 tonnes per annum of ceramic tiles for floors and walls
as a 100% Export Oriented Unit (EOU).
- In view of a downturn in the market, an application was made to
Govt. for allowing the unit to opt out of 100% EOU scheme.
- Subject to the following conditions the Govt. vide their order
dated 1st January, 1987 permitted the Company to opt out of 100%
EOU Scheme:
- (i) that 30% of the annual production must be exported for a
period of 5 years;
- (ii) to pay all duties upon plant, machinery and raw materials
previously exempted; and
- (iii) to pay a penalty at 10% on the value of capital goods
- Balance 30,000 shares allotted. 112,300 shares then forfeited.
1987 - Production was seriously affected till December due to severe
power cut and interruption in the supply of LPG for about a
1989 - 13,40,000 Rights shares offered at par in prop. 1:3. Only
13,22,619 shares taken up. The balance 17,361 shares along with
permitted retention of 2,01,000 shares allotted privately.
Employees quota of 67,000 shares allowed to lapse.
1990 - Operations were affected for 5 months due to insufficient supply
of LPG.
- 40,00,000 rights shares issued at par in prop. 18:25 in Sept.
Additional 6,00,000 shares allotted to retain oversubscription.
Another 2,00,000 shares offered at par to employees (unsubscribed
portion, if any, was allotted to Mutual Funds). 12,300 forfeited
shares reissued at par to dealers of the Company on 29th
1992 - Exports in the previous year were severely affected due to
disintegration of USSR.
- The Company undertook expansion of its capacity from 25,000 TPA.
- The Company had entered into an agreement with Gas Authority of
India Ltd., for supply of Natural Gas for the major input in the
tile manufacturing is LPG & LDO. Govt. of India had
substantially increased the cost of LPG, hence the company
approached GAIL for a continuous supply of gas. As per the
agreement the Company is to be supplied gas on a regular basis
from 1st April 1994.
- The Company is eligible to draw 35,000 standard cubic mtrs. per
day of gas. The Company proposed to instal a Genset to save
substantially on the power cost.
- Subject to necessary approvals being obtained, the company
proposed to make a Rights issue of equity shares or fully
convertible debentures for an aggregate amount not exceeding
Rs.650 lakhs at a prem. not exceeding Rs.10 per share on
allotment or on conversion.
1993 - The Company undertook to enhance its capacity by adding another
15,000 tonnes to the existing capacity.
1994 - In October, 32,55,800 shares allotted on preferential basis to
-Equity shares delisted from Hyderabad & Madras Stock Exchanges
- Regency Ceramics Ltd has informed BSE that Sri. N Satyendra Prasad has been appointed as Chief Executive Officer (CEO) of the Company with effect from February 27, 2009.


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What is it and what is it used for?
2 replies
It's used for making the Nicholas Lodge gumpaste recipe found on this site and also his website nicholaslodge.com.
You can also add it to fondant to make quickie gumpaste.
it is also used for making edible glue.. this recipe is also on nicholas lodge site.... different people make it different ways...hth


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Palm Garden of Largo
Talk to a Family Advisor:
Reviews of Palm Garden of Largo
lmc001 May 28, 2015
I am a friend or relative of resident
My Mother-in-law resides in this facility for just under a year. The staff are very kind to her and treat her with respect. They go out of their way to make sure she is happy and well cared for. The building has recently undergone renovations and is absolutely beautiful. I have no complaints about the care or facilities. Our experience has been great.
PHILYLYN May 13, 2013
I am a friend or relative of resident
Great place! My father was there for 3months 11 years ago after a head injury. He could not have gotten better care! Everyone there goes out of their way with both patients and family. Mon was there for a few months after her triple bypass a couple of years ago and is back there with breathing difficulties now. Another great thing is that many of the staff are still there 14 years after my Dad was there and the staff still remembers our family. My parents have been treated like family members! Palm Gardens is the next best thing to being home!
crowgirl December 12, 2012
I am a friend or relative of a resident
My mother was in this faciiiy for just a short time, but everyone we had dealings with was so nice and professional. They were prompt when you needed them and so kind.
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From Palm Garden of Largo
Palm Garden of Largo is a Five Star 140 bed skilled nursing facility, dually certified for Medicare and Medicaid. Our facility prides itself in providing quality rehabilitation and a caring staff.
Palm Garden of Largo is located 8-12 miles from the following hospitals: Northside, St. Petersburg General, Largo Medical and Morton Plant Hospital, Suncoast Hospital and Healthsouth Rehabilitation.
Palm Garden of Largo is located 8-12 miles from the following hospitals: Northside, St. Petersburg General, Largo Medical and Morton Plant Hospital, Suncoast Hospital and Healthsouth Rehabilitation.
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- Date Certified: 05/01/2017
- Resident Capacity: 140
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Recently, the company announced it had secured a new extension to its senior credit facility with lower rates and a longer term. "Our credit facility amendment and extension allows us to take advantage of low rate financing in the event rates begin to rise," said Gallagher. "We increased the size of the facility, negotiated lower rates, brought in a new lender and received a new long term agreement. Our debt levels even after this growth are consistent with the asset valuation base we have and is well within our lender covenants. The current low interest rate environment and hugely successful low cost leasing program we put together with our lenders allows us to grow at these levels using only our own cash and credit and that is a good thing for shareholders."About Student Transportation Founded in 1997, Student Transportation Inc. (TSX:STB) (Nasdaq:STB) is North America's third-largest and most progressive provider of school bus transportation services, operating more than 9,500 vehicles. Student Transportation's family of local companies delivers safe, reliable and cost-effective transportation solutions to school districts throughout the U.S. and Canada. Services are delivered by drivers, dispatchers, maintenance technicians, terminal managers and others who are caring members of their local communities. For more information, please visit www.rideSTBus.com . Forward-Looking Statements Certain statements in this news release are "forward-looking statements" within the meaning of applicable securities laws, which reflect the expectations of management regarding, among other matters, STI's revenues, expense levels, cost of capital, financial leverage, seasonality, liquidity, profitability of new businesses acquired or secured through bids, borrowing availability, ability to renew or refinance various loan facilities as they become due, ability to execute STI's growth strategy and cash distributions, as well as their future growth, results of operations, performance and business prospects and opportunities. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may", "will", "expect", "intend", "estimate", "anticipate", "believe", "should", "plans" or "continue" or similar expressions, and the negative forms thereof, suggesting future outcomes or events.
CONTACT: INVESTOR CONTACTS: Student Transportation Inc. Patrick J. Walker Executive Vice President and Chief Financial Officer Keith P. Engelbert Director of Investor Relations (843) 884-2720 Email: email@example.com Website: www.rideSTBus.com


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117 acres in Sharp County, Arkansas
117 ACRES +/- EXCELLENT HUNTING - HARDWOOD AND CEDAR TIMBER WITH ATV TRAILS. The cabin has 3-bedrooms, 1.5 baths, hardwood and tile flooring, large porch. Shop building, barn and shed. State Hwy. frontage. IDEAL FOR FAMILY HUNTING. ONLY A FEW MILES TO THE HAROLD ALEXANDER GAME RESERVE.
Hwy. 58 to Williford, cross Spring River continue on Hwy 58 approx. 4 miles to property on left.
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Chrissie Wright
Wright-Pace Real Estate
1115 Windover Road, Suite B
Jonesboro, Arkansas 72401
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NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


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When choosing the path will have to be smart and strategic thinking, here we need to weigh everything correctly, on the one hand, you can go directly to collect and little cubes of the other collecting dodge cubes and succeed in the end, you also need a happy medium. Some cubes are a special bonuses opening new events through which you can earn a lot of points, and other bonuses. There are four levels of difficulty, detailed tutorial, world statistics, colorful graphics, forty-two level, a lot of dynamics and sound.
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Allows the app to create network sockets and use custom network protocols. The browser and other applications provide means to send data to the internet, so this permission is not required to send data to the internet.
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text: Modelling and robust control of a soft robot based on conjugated polymer actuatorsAmir-Ali Amiri Moghadam, Majid Moavenian, Hamid Ekhteraee ToussiIJMIC2011In this paper, modelling and robust control of a two segment robot arm made from polypyrrole is proposed. Conjugated polymer actuators can be employed to achieve micro and nano scale precision, having a wide range of application including biomimetic robots, and biomedical devices. They can operate with low voltage while producing large displacement, in… (More)


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Choc Chip Date Nut Cake
Recipe by Lady in love
This is an easy home made cake with a delicious crunchy topping on a super moist cake! It is not super sweet but rather you taste the cocoa. People tend to put to much of the toppings on, big mistake stick to the recipe amounts! Dates are some times hard to find, so I order my chopped dates on line in 8oz pks. Dromedary are my favorite, but Sun Maid , or Dole are good too.Enjoy!
Top Review by waynejohn1234
Have been making this cake for years and feel it is a recipe that is often overlooked. It is one of our favorites. Only difference I make is to use half butter because we don't care for a shortening taste. Agree with your comments re too much topping. Highly recommend this cake for any occasions. Great warm with some good vanilla ice cream.
See Discussion:2 Reviews
Ingredients Nutrition
- 226.79 g dates
- 4.92 ml baking soda
- 295.73 ml boiling water
- 177.44 ml shortening
- 236.59 ml sugar
- 2 eggs
- 354.88 ml flour
- 29.58 ml cocoa
- 2.46 ml salt
- 118.29 ml sugar
- 170.09 g package chocolate chips
- 118.29 ml walnuts
Directions See How It's Made
- First pour baking soda and boiling water over chopped dates set aside to cool.
- Cream together 3/4c shortening, 1c sugar, & 2eggs. Set aside.
- Date mixture-Sift together 1 1/2c flour, 2tbl sp Coacoa, 1/2 tsp salt.
- now add the date mixture to the creamed mixture and stir in the cooled dates.
- Put into a sprayed and lightly floured 9 X 13 pan. I just use Pam w/ flour nonstick spray.
- Topping- Stir together 1/2c sugar, 1c choc chips, 1/2c chopped walnuts. Mix together and sprinkle over cake.
- Bake at 350 for 35-40 min or untill toothpick comes out almost clean. Do not over bake!


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Immortelle Precious Cleansing Foam gently cleanses the face and eliminates impurities while preserving the freshness of young skin.A part of our Immortelle Precious anti-aging skincare collection, this foaming cleanser helps to smooth and firm the skin. Made with organic immortelle floral water, it provides a unique moment of relaxation, leaving behind the soft floral fragrance of this golden flower.
‹‹ This is the most interesting thing that makes me love l'occitane. This refill is double size with the normal size. It helps us save a lot of money for buy a new one. ››
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This Immortelle Brightening Cleansing Foam Eco-Refill contains enough formula to re-fill your regular bottle twice.Use the cleansing foam every morning and evening on wet skin, avoiding the eye contour area. Gently massage over the face, then rinse off with water.
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Press release by Culpeper County Sheriff's Office:
Culpeper County Sheriff's Office arrested two this week for eluding.
At about 2:30 a.m. Tuesday, March 10, 2015, Deputy Charles Burgoon initiated a traffic stop for defective equipment on a white minivan on northbound James Madison Highway at Brandy Road. When the vehicle stopped, the driver- later identified as Johnathan B. Shellington, 27, of Catlett- fled from the vehicle and into a field. Deputy Jonathan Kerns, K9 Karma, and Corporal Charles Wheeler responded to assist in searching for Shellington. Culpeper Police Department assisted by setting up a perimeter. CCSO units tracked Shellington through a briar patch and across a creek and located him under a school bus in a VDOT storage lot about a quarter-mile from the minivan. Burgoon arrested Shellington for eluding and found him to be wanted by Fauquier County for three probation violations on original robbery, breaking and entering, and malicious wounding charges. Shellington is held without bond at Culpeper County Jail.
A passenger, Tina M. Shellington, 30, of Catlett, was arrested for obstruction of justice for providing false information to law enforcement about Mr. Shellington's identity. She was released from Culpeper County Jail with a $1500 secured bond.
At about 8:44 p.m. Thursday, March 12, Deputy Joshua Haught initiated a traffic stop for defective equipment on a green and silver Dodge pickup on northbound James Madison Highway, about 0.5 mile north of Braggs Corner Road. The vehicle continued in the right lane at about 40 mph, and Haught called a pursuit at Brandy Road. The vehicle accelerated to about 80 mph, passing vehicles in the left lane, into Fauquier County, and Fauquier County Sheriff's Office joined the pursuit. The vehicle turned on Route 28, came back into Bealeton, and pulled into a long driveway on Collins Lane, where the driver- later identified as Rodney D. Leavell, 29, of Culpeper- fled from the vehicle. Fauquier deputies apprehended Leavell as he tried to run into a bar. He was transported to Culpeper magistrate's office and held without bond at Culpeper County Jail on Haught's driving revoked and Felony eluding charges, Fauquier County's Felony and misdemeanor eluding and driving revoked warrants, and an outstanding CPD probation violation warrant for an original DUI charge.


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Media kit
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Jacqueline ToppingsCONTACTMedia Inquiries ADDRESS7930 Jones Branch Drive
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McLean, Virginia 22102
Property Profile
Hilton Al AinOpened: January, 1971
United Arab Emirates
Tel: +971-3-768-6666
Fax: +971-3-768-6888
Hotel Fact Sheet Download Fact Sheet »
Hilton Al Ain is happy to announce its commitment towards a sustainable and eco-friendly environment with the installation of the first ever small size food composting machines within the Hilton Worldwide. The machines were installed after participating in the Hilton Worldwide Travel with Purpose 2015 Program.
This month, Hilton Al Ain has delicious food and beverage specials, parties, gatherings and more happening to make sure guests enjoy the festive season.
Hilton Al Ain has partnered with the city's top attractions, Wadi Adventure Water Park and Al Ain Zoo, to offer families the ultimate summer adventure.


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Easter Schedule Downtown
Catholic St. Patrick's Old Cathedral, 263 Mulberry St., Good Friday The Liturgy of the Lord's Passion 3 p.m., Good Friday Via Crucis/Way of the Cross (Spanish and English) 5 p.m.,*Spanish Liturgy follows this, Easter Sunday Mass 9:15 a.m., 11:30 a.m. (Spanish), 12:45 p.m., 2:30 p.m. (Chinese), 7 p.m. Lutheran Christ Lutheran Church, 123 East 15th St., Good Friday Adoration of the Crucified 6:30 p.m., Easter Sunday Resurrection of Our Lord Slacker's Sunrise Service 11 a.m. Presbyterian The First Presbyterian Church, 5th Avenue at 12th St., Good Friday "The Seven Last Words of Christ" 12 p.m., Easter Sunday Communion Service 8:30 a.m., Easter Sunday Services 9:30 a.m., 11:30 a.m. (*3 year old special Easter program after "Children's Prayer".) Episcopalian Trinity Wall Street, 74 Trinity Pl., St. Paul's Chapel of Trinity Church, 211 Broadway, Good Friday Liturgy and Veneration of the Cross (Trinity Church) 12 p.m., Good Friday the Way of the Cross (Trinity Church) 3 p.m., Good Friday with Children, Youth, and Families (Trinity Church) 4:30 p.m., Good Friday Liturgy (St. Paul's) 6 p.m., Easter Sunday Festive Eucharist 8 a.m. & 10 a.m. (St. Paul's), 9 a.m. & 11:15 a.m. (Trinity Church).
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Elk River City Council Member Jerry Olsen was appointed acting mayor Jan. 3 by his peers for the 2017 calendar year.
Olsen will serve as acting mayor, performing all the regular duties of the post in case Mayor John Dietz is ever absent from a meeting or if the position is vacant or until a successor is appointed.
While all council members were eligible for the appointment, Elk River has historically rotated which member serves as acting mayor, based on their ward, according to city documents. The rotating schedule corresponds with election terms and allows for a year of experience for new council members before assuming the role.


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Precise motion control is critical in a number of medical devices. Unfortunately, with the many options available to manufacturers, it is often difficult to know which solution is ideal for a particular application. This report will provide an overview of the indications and benefits of using ball screw technology to fulfill certain motion control needs.By Tarek Bugaighis
A "miniature" ball screw ideally suited for lab instrumentation
At a Glance Physical attributes
Selection variables
Addressing backlash
Example applications
Ball screws have long been prescribed as solutions to enable precise positioning in medical instrument applications, including syringe and other medical pumps, pipettes, coagulation analyzers, and liquid-handling systems. Whether performing pick-and-place or other automated operations, these anti-friction devices serve vital functions by converting rotary motion into smooth, accurate, and reversible linear motion to quickly and reliably position loads.
Over the years, ball screws have given competing technologies a run for their money and will often provide the ideal method for linear drive systems. This is especially true when compared with sliding screws, which present higher friction coefficient and, consequently, have lower efficiency. Innovations in ball screw design technology have further advanced their appeal.
Ball Screw FundamentalsBall screws consist of a screw shaft, nut, balls, and a ball recirculating system. Components are usually made from a variety of hardened or stainless steels, well-suited for medical applications.
A cross-section of a typical ball screw (with circulating balls)
Their configuration consists of a shaft with precision ground or rolled concave helical groove (acting as the inner race) and nut with internal grooves (acting as the outer race). Circuits of precision steel balls circulate in the grooves between the screw shaft and nut. Depending on the application, either a rotating screw shaft or nut will then translate in a linear direction. The ball screw has a natural ability with a high efficiency to convert about 90% of a motor's torque into thrust, which results in minimal mechanical wear and constant performance throughout the life.
Return devices are intended to create smooth and efficient recirculation of the balls from the end of their load-carrying path back to the beginning to complete the circuit. A relatively new ball-return design features a robust "no-tubing" internal system, whereby balls in each circuit are removed from the raceway and returned to it by solid metal deflector pins. This eliminates all external tubes (and the possibility of damage upon installation) and delivers high-speed operation without interference from tubes.
Lab instrument applications exert particular demands on linear drive systems and related issues abound. Systems must be engineered to operate quietly, accurately, and safely; accommodate higher dynamic loads to facilitate compact instrument design; and serve reliably over time. Ball screw technology has, in turn, kept pace.
As an example, "miniature" precision rolled ball screws ideally suited for lab instrumentation have been developed with standard diameters ranging from 6.0 to 16 mm and leads ranging from 2.0 mm to 0.5 in. Among the noteworthy advantages:
A cross-section of the "miniature" type ball screw
Diagnosing the ParametersWhen selecting a ball screw for a medical equipment application, a variety of critical parameters should always be evaluated. These include (but are not limited to) load profile, linear and rotational speed, rates of acceleration, cycle rate, drive torque limits, environmental issues, required life, lead accuracy, and system stiffness. All will have an influence on performance and as much information as possible for an application should be predetermined and communicated before ball screw selection.
In matching a ball screw to an application, users may want to pay special attention to other important issues, such as backlash and the type of support bearings when making the decisions.
Backlash (with a maximum of 70 µm and even less if required) is the relative axial motion between the screw and the nut when the motor is not turning. In a vertical motion application, where the load constantly pushes down on the nut, backlash is not an issue, because load will enable permanent contact to keep the highest accuracy in the motion.
A variety of ball screw assemblies
Backlash can be avoided by opting for ball screws with preloaded nuts. Preload can be applied with plus-size rolling elements or with an axial force applied to a split/tandem nut. The applied preload eliminates any axial play and increases the stiffness of the assembly. High preloaded nuts are subject to less elastic deformation than non-preloaded types, which increases reliability and accurate positioning under load.
The degree of support on each end of a ball screw in a lab instrument will determine how fast the screw can spin and how much load can be handled. Simple supports are typified by deep groove ball bearings, which offer good radial stiffness but poor axial stiffness, while fixed supports (such as pairs of angular contact bearings) will provide stiffness in both directions. Shafts can also be left "free" when coupled with a fixed configuration on the other end, which means no support. Application demands will help guide choices.
Optimizing Performance
Ball screw assemblies in all their varied types and styles can provide long predictable life and efficient service in the medical setting. But a good part of their promise hinges on their design and actual operating conditions.
For example, thermal expansion of the screw shaft can lead to systematic positioning errors, which needs to be accommodated in the system software and with the mounting conditions. Keeping the operating temperature of the screw constant is critical to high repeatability of positioning. A control of the temperature helps also to define the optimum lubricant that will allow the screw to perform at its best and with stable performance.
With the required demand for precise positioning, it is important to control the lead error of the screw. Lead precision of a screw can be classified as the difference between the theoretical and actual position on a given number of points along the working stroke. When two screws are used in parallel, units with matched leads should be employed, unless they can be controlled independently with a linear encoder and different servomotors.
To create optimum system stiffness or eliminate backlash, a preloaded screw may be required, but at the same time the drive torque might also be increased if the output force is low compared to the preload level. It is therefore always recommended to calibrate the preload force with accuracy to minimize some side friction effects introduced by the preload on one hand and to achieve the stiffness expected on the other hand. In addition, it may be necessary to include the preload torque as part of the total useful torque when sizing the motor.
Whenever evaluating ball screws for a particular medical equipment application, the first rule of thumb is to understand that a solution for one application may be inappropriate for another.
Beyond the standard life calculation, torque requirement, and output force evaluation, many other parameters must be considered, such as noise level, smoothness, repeatability, speed and acceleration, lubrication, and coatings. All should be evaluated during the design phase so that the product will operate with the expected reliable performance. Perfect traceability during the manufacturing process is also a "must" for all high-tech applications.
Partnering at the outset with an experienced manufacturer can help chart the most appropriate decision-making course.
ONLINEFor additional information on the technologies and products discussed in this article, visit SKF USA Inc. at www.skfusa.com [1].
Tarek Bugaighis is the director of medical business development for SKF USA Inc., 1530 Valley Center Pkwy., Bethlehem, PA 18017. He is responsible for supporting the medical industry with the company's assortment of linear and rotary motion products and services. SKF is a leading global supplier of products, customer solutions, and services in the rolling bearing, linear motion, and seals business. Bugaighis can be reached at 610-861-3705 or firstname.lastname@example.com [2].


text:
Time: 7:00 pm – 8:00 pm
Free Admission
AlmaNova is a talented, classically trained flute and guitar duo presenting an eclectic program of music from all over the world. The duo's great love of all musical genres shines through to their audience by way of dynamic performances and mesmerizing stage presence. AlmaNova has traveled all over the world playing their unique blend of classical repertoire with music from the Balkans, Spain, Latin America, and the British Isles.
Live! at the Museum is an ongoing series of early-evening concerts in the museum's galleries, a feast of sight and sound. In presenting the series, Laguna Art Museum has partnered with Laguna Beach Live!, an organization cherished by music lovers for its work in bringing performances by top-level, professional musicians to the Laguna Beach community. Not only are the galleries an appropriately beautiful setting in which to experience great music, they also boast fine acoustics. The concerts take place the second Thursday of each month from 7:00 to 8:00 p.m.
To reserve your tickets, please make a reservation online through our website, or contact Membership Manager Valerie Tate at 949.494.8971 x203. Tickets will not be available for online purchasing after 4:00 p.m. the day of the concert, but will be available at the museum front desk. Reservation holders are advised to arrive no later than 15 minutes before the performance, otherwise your seats will be released to the waiting list. Seating is on a first-come, first-served basis.
Laguna Art Museum
307 Cliff Drive
Laguna Beach, CA 92651


text:
Address: 2600 Technology Dr Ste 500, Plano, Collin, Texas, 75074
Phone Number: 972-422-7301
Address: 2600 Technology Dr Ste 500, Plano, Collin, Texas, 75074
Phone Number: 972-422-7301
Voting for a business allows it to have a running tally. If a business hasn't been positively voted for yet the displayed number will be 0. Negatively voting for a business will not make it fall below zero, however it will decrease the number of votes a business has if their tally is more than 0
The recommendation system is a way for customers of Al's Plumbing to let other people know whether they would recommend the business. You may recommend for or against using this business and your recommendations will affect this business's User Recommendation Score on Home Services Engine.
No public recommendations have been added for this business yet.
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text:
i m just informing you changing link color in threads and post are impossible!
if i creating a thread and added a link .. and if i try to change color of link .. it is not working!
i tried may ways to change link color but still not working ... after that i thought it is problem with only one place so i visited more xenforo forum and founded same problem .. ! and not other forum only ... it is not working here to on xenforo community!
well i can change link color if i do it in 2 part .. for example link is Xenforo Community and if i try to change link color .. then it is imposable and if i change color of one word at a time then it can be done .. so if you want to change link color from starting of link text to end of link text ... it is impossible !!


text:
What you "want" to drive and what you "need" to drive unfortunately don't always intersect. In a perfect world we'd all live somewhere that offered convertible-friendly weather 365 days a year, and never have to deal with daily commutes that creep slowly along the freeway at a clutch-killing pace. sports cars and drop-tops might not always make sense from a practicality standpoint, but that doesn't mean you are completely out of luck - many automakers offer a very similar, but much more real-world friendly model alongside their aspirational automobiles that can make an intriguing alternative to parking a topless two-seater in your driveway.
Let's take a quick look at four aspirational automobiles and their more responsible alternatives.


text:
Question: Why may a dividend increment lag after an increase in 125854
Why may a dividend increment lag after an increase in earnings?
View Solution:
View Solution:
Answer to relevant QuestionsWhat is the difference between liquidity ratios and activity ratios?What does the statement of cash flows add to the analyst's knowledge of the firm?If a firm has sales of $42,791,000 a year, and the average collection period for the industry is 40 days, what should this firm's accounts receivable be if the firm is comparable to the industry?What is the problem with time lags in technical analysis and why may the analysis lead to self-fulfilling predictions?In May 2006, Vonage (symbol VG) went public at $17. What subsequently happened to the price of the stock one, two, and three months after the IPO? (One means to answer this question is to locate historical stock prices using ...
Post your question


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McCall 5011; ca. 1927; Ladies' & Misses' Two-Piece Dress (Right). Two styles of sleeves. Applied neck trimming.
Picture from November 1927 McCall Style News.
Links to reviews/blog postsEdit
Add a photo to the gallery by clicking the "modify" button below.
[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


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We ship to over 100 countries, including:
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Style: 91A0076 Color Code:
Over the knee fishnet socks with lace up detail along the front.
70% Cotton 30% Spandex Hand Wash * Imported
Lace Up Fishnet Sock styled by the FP Me community
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Cream Cheese Bars
READY IN: 35mins
Recipe by Joy1996
Top Review by Heather Maleather
This recipe has potential, but I followed it EXACTLY and it didn't quite turn out how I expected it too. The main problem was the crust. There is nothing in the recipe to hold the crust together, so it was very flour-y and didn't really stick together very well, even after I poured the filling over it. Overall it needs some adjustments.
See Discussion:1 Review
Ingredients Nutrition
- 1 1⁄2 cups flour
- 3⁄4 cup brown sugar, packed
- 1⁄2 cup quick-cooking rolled oats
- 1⁄2 cup peanut butter
- 8 ounces cream cheese
- 2 eggs
- 1⁄2 cup granulated sugar
- 1 teaspoon vanilla
- 7 1⁄2 ounces Hershey Bars
- 1 tablespoon peanut butter
- 1 1⁄2 tablespoons butter or 1 1⁄2 tablespoons margarine
Directions See How It's Made
- For Crust: Mix all together until crumbly and press into a 9x13"pan.
- Bake at 350 degrees for 10 minutes.
- For Fillling: Mix all together and pour over crust (no need to cool), return to oven and bake for 15 minutes, or until filling is set.
- For Topping: Melt the Hershey bar with the peanutbutter and butter or margarine and spread over top.
- Cool completely and cut into bars.


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Originally launched in 2003 under the name of HalfLife2.net and vBulletin 2.x, we eventually rebranded in 2012 to ValveTime.net and simultaneously ditched vBulletin 4.x for XenForo.
And thus began my journey with XenForo.
Two years later, we were still running XenForo 1.1.5 and stuck on an aging style that would have been too much effort to maintain and make fully responsive for XF 1.2.
TODAY we upgrade to XenForo 1.3.3 and with it we introduce a brand new custom style created by @Audentio and based on UI.X and Quark.
After installing (or in some cases before installing, thank you 1.2 and 1.3 Upgrade Guide! @Brogan) we were able to remove a total of 18 add-ons which pretty much had direct replacements of core features in XenForo 1.2 and 1.3.
I still have a lot to do, but it was breaking my heart seeing the site on 1.1.x and so today is just the beginning, hopefully.
Today also marks the day that we finally shut the door and never look back on XenPorta. I won't lie, we used to think it was pretty good. Then we needed support once. And with the opportunity to practically start again, and seeing the appalling behaviour of a certain person recently, there was no doubt in my mind that XenPorta had to go.
Thankfully, there are now other solutions today. And by far the best, in my opinion, is Featured Threads by @Brogan. He has done a wonderful job, and practically took zero effort to make it look good on our new custom style.
So, here we are, finally in the year 2014 and although I don't anticipate it will make a massive difference to our dwindling community, I certainly feel happier that the visitors that we do still get are now seeing the best possible style, on the best possible platform, with the best possible portal as a front end.
So thanks to everyone who has made that possible!


text: Laws and Legislation Emirates Identity Authority: Independent Federal Authority established in accordance with Federal Decree number 2 for 2004, which conferred it all powers required to execute and develop the draft program of the Population Register and the ID card in the United Arab Emirates. The Federal Law number 9 for 2006 about the Population Register and ID card dictated the creation of Population Register system with the aim of registering individual data and civil incidents for UAE nationals and for non nationals residing in the country, and the issuance of a card called the "ID card" for each individual registered in the Population Register System. Download PDF file


text: This weekend, be sure to join HAWS Mobile Adoption Center, the Friends of HAWS and lots of other pet-friendly people/places at Dog Day Afternoon at the Waukesha Expo Center. Sunday, Sept. 12th, from 10am - 2pm!(And now, a *PUN ALERT*)A big part of our fall fundraiser, HAWS Homecoming '10, is an old-fashioned Parade, complete with floats. The processional will wind through the entire Olympia Resort venue where our event is being held, leading our guests to the main room for a Live Auction - which will feature a 'KLH hosting gig, front-row-behind-home-plate Brewers tickets, a year-long massage membership, a dinner/moonlight boat cruise and more great items.Want to PARADE your business? Get in the game and help animals come home with a HOME-COMING float! It is sure to be a HIT PARADE and a PURR-fect way to keep your biz a-'float.' So go with the 'float.'Forget Sunday/sundae - we'll have a FLOAT!So how do you go about securing your very own 'float"ation device for HAWS? It is very easy: you give us a $100 donation and a 2'x3' sign with your business logo on it. We do the rest! We'll decorate your wagon (and we mean that literally - we're using little red wagons) and have an enthusiastic volunteer ready to be the wheels! All floats will be on display before and after the parade, too, in a pretty noticeable spot (the hallway to and from the Resort entrance) so you'll get lots of "play" at our Big Game!Interested? Call us at 262-542-8851, x107 or email email@example.com. By the way - adopters from now until October 9th will be able to purchase 2-for-1 tickets to HAWS Homecoming '10...and will be entered in a contest to win 2 VIP tickets! NOW is the time to adopt 4 paws from HAWS!


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It is never easy to write about loss, so I hope not only does this message provide some comfort and sincere condolences to Avonte Oquendo's family, but also hope to our community. Our hearts are heavy as we are saddened to have confirmation that the remains found on Friday were that of Avonte's. He is the 14-year-old autistic boy from Queens, New York that went missing back on October 4th.
I remember when the story broke on the National News. My eyes began to well up with tears and I developed a lump in my throat as I looked over at my 6-year-old son, who also is autistic, playing with his Spider-man action figures. So many thoughts and emotions were going through my mind. I could not imagine what his mother and family were going through at that moment. The fear, helplessness, and uncertainty of not knowing where your child is, is truly any parent's worst nightmare. Overwhelmed with empathy and hoping Avonte was safe, I remember giving my little guy a very protective hug and feeling as not wanting to let go. At all costs, I wanted to keep him safe and I hoped that he would never wander off.
Wandering is a major safety issue, especially with children of autism. Unfortunately it is very difficult to watch the news because these wandering cases are not isolated occurrences. Solutions include heightened security in schools and optional tracking devices. Hopefully over the next few months, through these solutions and awareness, we will find ways to eradicate this growing problem and safety concern with our children.
The past few months have been long and trying road for Avonte's family and though everyone's worst fears were confirmed, he is now at peace. Our deepest sympathy goes out to his mother, Vanessa Fontaine, and his family. We hope that all will respect their privacy as they grieve and take time to begin the healing process.
With deepest sympathy,
Lisa T. – Mother and Parent Advocate


text:
- Site Template
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CodeCanyon Event Log Writer 3755769
CodeCanyon Event Log Writer 3755769
.NET Script \ Miscellaneous
Event \ Queue \ Tasking \ Thread \ Windows \ Write \ Multi \ Safe \ Fast \ Work
.NET Script - Event Log Writer 3755769 by AvantPrime @ CodeCanyon
.NET Script \ Miscellaneous
Last Update: 7 January 13; Compatible Browsers: IE6, IE7, IE8, IE9, Firefox 2, Firefox 3, Firefox 4, Safari 4, Safari 5, Opera, Chrome; Software Version: .NET 2.0, .NET 3.0, .NET 3.5, .NET 3.7, .NET 4.0, .NET 4.5; Files Included: C# CS.
The Event Log Writer .NET component provides you with a simple and robust method to write to the event log. One of the major highlight of this component is writing to the event log at defined intervals on a background thread. This ensures that the performance of your applications remains at peak! This component also offers high performance writes using cached writers – creates the writers for you ensuring that the correct writer is always used without the overhead of creating a new one all the time.
This component is built using the .NET 2.0 Framework which means in can be used in all .NET applications that are using the 2.0 framework or newer. This includes .NET 2.0, 3.0, 3.5, 4.0, & 4.5. This component can be used all types of .NET applications including.
- Console
- Windows Forms
- Windows Services
- Web Services (XML/WCF)
The component also ensures that many pitfalls are not encountered including.
- Deadlocks – thread safety through locking avoids deadlocks
- Memory leaks – clean up through the dispose method & consider problems such as the lapsed listener
- Exceptions leaks – Exception handling through to ensure undesired termination of the application does not occur
- ASP.NET ThreadPool & Service Unavailable – Give control of whether ThreadPool threads are used or not (by default no). This ensures that threads are not taken away from high availability ASP.NET applications causing the dreaded "Service Unavailable"
- Task/Background work structure – Flexible mechanism for creating complex background operations
- Strong name signed – Allows referencing in other application that are strong named signed & also installed into the Global Assembly Cache (GAC)
The example shows how to use the event writers.
Write to event log
Console.WriteLine("Writing two entries to the event log..");
var writerSetting = new EventLogWriterSetting(LogName, EventSource);
using (var writer = new EventLogWriter(writerSetting))
for (int i = 0; i < 2; i++)
var message = string.Format("EventWriter message on {0}", DateTime.Now);
Console.WriteLine(writer.WriteToLog(message, EventLogEntryType.Information)
- String.Format("Successfully wrote to the event log. Message: {0}", message)
"Unsuccessful attempt to write to the event log."
Write to event log using cached writers
EventLogWriterCache.WriteToLog(DateTime.Now.ToString(), LogName, EventSource, EventLogEntryType.Information);
Write to the event log using the queue mechanism
Console.WriteLine("Configuring QueueWriter to write every 10 seconds starting after 10 seconds with a write delay between messages of 10 milliseconds.");
var writerQueueSetting = new EventLogWriterQueueSetting
(TimeSpan.FromSeconds(10), TimeSpan.FromMilliseconds(10), TimeSpan.FromSeconds(10));
EventLogWriterQueue.Setting = writerQueueSetting;
var writerQueue = new EventLogWriterQueue(LogError);
var message = new EventLogWriterQueueMessage
String.Format("Queue message: {0}", DateTime.Now.ToString(CultureInfo.InvariantCulture)),
Console.WriteLine("Polling every four seconds for new entries in the event log..");
for (int i = 0; i < 4; i++)
// Only dispose after your queue is empty
while (!EventLogWriterQueue.IsQueueEmpty)
You get a fully documented solution which includes the core file & test project. Also you get a comprehensive help file documenting full usage and you get compiled assemblies for immediate usage within your application.
Background Work Scheduler.
Keywords: Event Log, background work, c-sharp, cached event log writers, fast performance, multi-tasking, queue, thread-safe, windows event log, write to event log.
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text:
Need more advice? Ask the community a question.
I have PRo60 and SR60 Boston Acoustic speakers,All 3ohm, 85w front and 125w Rear. Also two older 12" Diamond DB6's at 4ohm a pc.600w a pc. What would be the best amps to run these speakers off of. D class? help me.


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Atmosphere and service during breakfast
the hotel is very nice, the breakfast is excellent. The price is a bit too high for accomadation.
extremely cozy and stylish design in room and in the hotel facilities No. If room rate could be less expensive.
the location i was excepting more modernity and better service...
One of the best hotels in the world. Highly recommend the Junior Suite. The food is amazing, and the service is second to none.
good room concept, smoking and non-smoking rooms available, spacious bar too expensive for its quality. not really efficient front desk (did not bring up items to the room as requested, but left them without notice at the front desk). when room was cleaned, full ashtray was not emptied (!). ridiculous charge for 5 min stirring (not cleaning) of 1 jacket and 1 pair of trousers: CHF 76.-
Elegant and with all modern facilities Toilets dont have locks
The design. I was not provided a non-smoking room as requested so I dislike the smell of cigars and cigarettes in my room during my entire stay.
In general every thing good and staff are very helpfull. No.
excellent service nothing
Room rate at CHF660 outrageous. Hotel not worth it. Restaurant closed on my Sunday night stay; having to walk down the road to find place for dinner not acceptable at that room rate.
The atmosphere of the hotel is great, as all the other Hyatt hotels. Actually I chose Hyatt because I have never been disappointed by this chain.
spacious rooms, room service and quite atmosphere at the lobby staff should be more attentive
yes, it`s expensive but the hotel is pure class.
Restaurant! Room
rooms and service decoration
The friendliness of the staff and the birthday card, champagne.
Seen many nice hotels and this is one of the best.
Attitude of staff, room layout, amenities.
yes, it`s expensive but the hotel is pure class.
Everything No
I like fitness,eating,room service. I like every things in this hotel.
It's in the middle of the city. For this high room price, the breakfast should be included!
Restaurant! Room
Fantastic boutique hotel, very stylish & comfortable with really friendly staff. No restaurant available.
Breakfast, service, cleanliness, location
great location during week very remote at night
Professional staff, beautiful room. I have stayed at several hotels in Zurich, but would return to this one, I think.
your friendly and helpful staff and reception. headboards of beds are not very comfortable
Excellent service, optimal location
Breakfast, service, cleanliness, location
Friendly staff No
Lovely suite, very clean helpful reception staff.
great location during week very remote at night
very cooperative and helpful staff
This was a basic business hotel. Nothing special about it, but very expensive.
Superb hotel. Very well positioned for Paradeplatz and Bahnhofstrasse. I can think of nothing bad to say about it.
Cheap, clean, friendly staff, with a gym.. nice and simple. I was only frustrated with the 40Fr/hr charge for late checkout.. there is NO GRACE PERIOD. Be aware of this. The rooms are also very small.
Comfortable beds,nice breakfast Dining room was very small.very small lift,staircase smelt of smoke
No a/c on the room,very hot at night
Very nice staff, stylisch rooms There is a bar next to the hotel, so you can hear the people talking loudly when you leave the window open at night.
Hotel location good Air conditioning working - room was like a sauna, opened the windows to reduce heat and put up with traffic noice.
Comfortable beds,nice breakfast Dining room was very small.very small lift,staircase smelt of smoke
It is in walking dictance from the centre of the town. The breakfast is poor and the room service elementary.
According to Booking.com I shoulc get 10% discount on food and free minibar. This did not happend.
The large, glass-walled shower was just right for a naughty romantic weekend with my wife. Glad the toilet had solid walls though! Location was about ideal for the old city. Beds were great (we'll be getting twin singles pushed close for our next bed purchase). The room faced a club and the street, which was noisy at night. While the windows were sound-proof, the room heated up quicky and the air conditioning was loud and largely ineffective, although like a waterfall we could habituate and sleep with it - it masked my snoring! We ended up leaving the toilet windows open but closing the main room's, and leaving the AC off. They say they'll be improving the AC.
Cheap, clean, friendly staff, with a gym.. nice and simple. I was only frustrated with the 40Fr/hr charge for late checkout.. there is NO GRACE PERIOD. Be aware of this. The rooms are also very small.
I enjoyed the green apples in the room, allthough they were not ripe enough to be eaten, nice breakfast. Pretentious design and unexperiienced staff. The staff was very reluctant to help with basic things and seemed very inexperienced. Two examples; I cut myself during breakfast but they seemed very confused and puzzled when I asked for a bandaid allthough the blood was dripping. What I got in the end wasn't adequate to stop the bleading. When I left, they refused to give me a receipt because I had used booking.com to book/pay for the room. I asked 4 times, really insisting that it seemed wrong and that I really needed a receipt, but they would not give me one. In the end, the girl came running out on the street waving a white enveloped when I had left and where stoving my bags into a taxi. (Getting the taxi was also not obvious
No Airconition it is very hot, the floor made of wood and make noise when moving around, very noisey becuse of street intersection at the corner of hotlel (no aircondtioner) and small lift
Unfortunalely, the bathroom door and handle were quite dirty. But everything else was great.
Location was great and the breakfast and restaurant were also very good TV and hardline internet didn't work and they didn't even attempt to fix it the whole time I was there (2 weeks).
Pleasant room, convenient to shops and station. Friendly reception staff A little noisy due to its central location. Would have like to order snack from room service, but only asian fusion food available.
Great location, close to main section of Zurich. A little expensive for what you get, however, the location is what I feel I paid for.
Extremely welcoming. An obviously large amount of repeat business given the conversations overheard from a steady stream of arrivals whilst I was waiting in reception for a colleague. Great business location and very comfortable. Make WiFi free and easy to access in all rooms in this modern business age
Very good breakfast a bit run down and expensive for value
Maintenance has some problems: Two lights were not working in the room at first. After notification to the desk one was fixed, while the repair of the second was only accomplished after another call, taking one day
The Internet-TV in a room of hotel was pleasant. One lack - TV programs from Russia were inaccessible. 1. The teapot did not work also I could not prepare for tea to itself. 2. The floor in a bathroom was very cold and I have not find out as it is possible to switch on heating of a floor.
The hotel is well situated in the middle of the town with easy access to everything. Breakfast was excellent.
The staff were very helpful. I lost my phone during my stay and the hotel staff found it for me! The restaurant attached was very good too.
Very good location. Superior double room big enough & comfortable,very good breakfast,
Staff were all friendly Room kept us warm on snowy days Bed was very big and comfortable The air circulation was very good Bathroom was clean I would stay here again whenever I visit Zurich
compared to others still reaonable expensive
The cleanliness and the staff. The location is not far to the lake as well as to the center, but it is not in the center. Internet was free in the reception area. I booked 2 rooms, one of the was with no toilet door. the other thing is they did not allow me park my car in the carage. They have a rule to keep the key with them only for parking.
Staff were all friendly Room kept us warm on snowy days Bed was very big and comfortable The air circulation was very good Bathroom was clean I would stay here again whenever I visit Zurich
Nothing special, standard hotel, small rooms for a 4*
The courtesy of the staff.
Loved the hotel's modern, comfortable room and its convenient location. A 5 min walk into Zurich's city center. Price ($250) was steep for one night's stay.
location deficient aircondition, several TV channels offered on the menu were not available, no telephonedirectory in room, defective teapot, no continental breakfirst as an option.
small room and small toilet
Good Service
Its closeness
compared to others still reaonable expensive
It was a bad experince The bed, the bathroom, the room, the air condition and the value of money


text:
Popular Now
Popular Now
Popular Now
Popular Now
01803 865913
+44 1803 865913
Series: Falcon Rockhounding Guides
By: Gail A Butler(Author)
228 pages, b/w photos, maps
Although known for its gold production, California is a virtual haven for rock and gem collectors. With this fully revised and upated edition, you can explore the mineral-rich desert regions, comb tide-washed beaches for jade, agate, abalone, fossilized whale bone, and prospect in the mountains and hills for gold, copper, and other minerals and gems. It describes 75 of the state's best rockhounding sites and covers popular and commercial sites as well as numerous little-known areas. This handy guide also describes how to collect specimens, includes maps, directions, and GPS coordinates for each site, and lists rockhound clubs around the state.
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Students have many afternoon field trip opportunities as part of the lab components of geology courses. These field trips include examining the stratigraphy and fossils of sedimentary rocks that form the Appalachian Plateau, glacial deposits that were formed during the last ice age, watershed systems, and coastal processes along Lake Erie.
Contact Geology
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Earth & Environmental Science Career Day
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On 2008-12-30 09:37:22 PM, goldensunphotography gmail com wrote: > I am a "regular joe" visitor to your website.I'm pretty savvy with > computing but still chained to Windows XP.I'm passionate about saving > the world and ,upon reviewing the benefits of an open source operating > system,would love to try it. > Then i get stuck.And I mean stuck! > Does the open source community cater just to the Technically > Advanced?Doesnt this run counter to the set goals of the open source > community? > Surely at some point the open source community (and your website) must > make this revolution available to all.Even though your "product" is > free.....no-one knows how to use it! Can you please tell us exactly where you got stuck? We'd be happy to help you out or direct you to the right place for your question. Thanks, Ricky
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I know it's not broken because when i charge my device and unplug it, i can hear the sound which indicates its charging. I tried holding onto the power button for a while to see if it would turn on, but it wouldn't. and plus my home button is broken. please help?
Most Helpful Girl
You use ipods still?00|00|0
... im not 18 years old. aha
Millennial burn... maybe?
No seriously. I honestly thought they stopped making ipods. I'm gonna go see what my last one was if I can find it.
Also if the other responses didn't help - let the battery drain completely and then charge it again through a wall socket. It used to happen to my nano and id leave it for a week and the recharge it and it would work.


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This Hotel is a jewel. It is in a perfect location for anyone visiting Paris. Just around the corner, a few miutes away is theNotre Dame Cathedral. Fabulous, Awesome to be able to walk. The little streets are filled with lovely shope, cafes and patisseries.
What more could you ask for.
The hotel staff are wonderful, very helpful and pleasant. They are there to serve, to make your stay in Paris everthing you desire.
I recommend this hotel highly but advise you to plan ahead. It is a small hotel so you must make you reservation months in advance.
They do offer a shuttle service from the airport, there is a charge.
I hope you will have a pleasant journey and enjoy the Hotel St Louis as much as we did. Au revoir
- Official Description (provided by the hotel):
- In the heart of Ile Saint-Louis, the hotel Saint-Louis en l'Isle has an outstanding location. A very quiet place in the middle of Paris, the Ile Saint-Louis is a village with a prestigious history, symobolized by the 17th century town houses that lie there. Very close to Notre-Dame cathedral, the Marais quarter, the Place de la Bastille and the Saint-Germain quarter, you will find in Ile Saint-Louis unique Parisian authenticity, well-being and hospitality. A charming hotel by excellence, the hotel Saint-Louis en l'Ile will welcome you in a warm atmosphere. Visible stones, old terra cotta and oak beams make this place unique. An elevator serves all floors, including the stone vaulted basement where breakfast is served.Whether your visit is for tourism or business, the hotel Saint-Louis en l´Isle will see to your needs. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Travelocity, Orbitz, Expedia, Hotels.com, Priceline, Hotwire, Cheap Tickets and TripOnline SA so you can book your Hotel Saint-Louis en l'Isle reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Saint Louis Hotel Paris
- Hotel St Louis Paris
- Hotel Saint Louis Paris


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Cast members such as Chris Pratt, Zoe Saldana, Pom Klementieff, Elizabeth Debicki, Dave Bautista, Kurt Russell and Sylvester Stallone looked dazzling on the purple carpet.
"Guardians of the Galaxy Vol. 2" held a Los Angeles premiere at the Dolby Theater in Hollywood on Wednesday, April 19. The event was attended by cast members, who include Chris Pratt, Zoe Saldana, Pom Klementieff, Elizabeth Debicki, Karen Gillan, Dave Bautista, Kurt Russell and Sylvester Stallone. Director James Gunn was also present on the purple carpet.
Star-Lord himself, @prattprattpratt, back on Earth for the #GotGVol2Premiere! Watch: https://t.co/vWhBLL70gW pic.twitter.com/3ZHZbrsEsO— Marvel Entertainment (@Marvel) April 20, 2017
Pratt attended the premiere along with wife Anna Faris. The Star-Lord depicter looked dapper in his grey suit, while Faris looked lovely in her Marchesa classic white dress. Saldana looked dazzling in her acid bright orange mini dress from Emilio Pucci's Fall 2017 ready-to-wear collection, while Gillan opted for a lovely yellow attire from Monse. Debicki, who portrayed villainous Ayesha in the movie, shone in her silver gown.
Make way for @zoesaldana, the deadliest woman in the universe! #Gamora #GotGVol2Premiere Watch: https://t.co/vWhBLL70gW pic.twitter.com/1BKIkFk56L— Marvel Entertainment (@Marvel) April 20, 2017
.@karengillan, the infamous Nebula herself, has arrived! Tune in, thanks to @ComicaveStudios: https://t.co/qUEoAYJJ5H #GotGVol2Premiere pic.twitter.com/yJDGr4xJxG— Marvel Entertainment (@Marvel) April 20, 2017
The villainous Ayesha herself, Elizabeth Debicki, lighting up the #GotGVol2Premiere! Watch now: https://t.co/vWhBLL70gW pic.twitter.com/hSUKrMCIDz— Marvel Entertainment (@Marvel) April 20, 2017
During the premiere, Debicki shared a few details about her character, saying that Ayesha was a "pretty extreme character" and didn't have any sense of humor. She also gave an overview about the costume she wore in the movie. "The dress is incredible, I've certainly never seen anything like that. It takes a lot of manpower, woman power to move it," said Debicki. "It's very heavy and of course it is quite extreme," she added.
Russell, who plays Star-Lord's father Ego, expressed his excitement at the movie by saying that he loved all the characters in it as well as "the relationship between the people." He added, "It what makes the movie has so much emotion."
Set to the backdrop of "Awesome Mixtape #2", Marvel's "Guardians of the Galaxy Vol. 2" continues the team's adventures as they traverse the outer reaches of the cosmos. The Guardians must fight to keep their newfound family together as they unravel the mysteries of Peter Quill's true parentage. Old foes become new allies and fan-favorite characters from the classic comics will come to our heroes' aid as the Marvel cinematic universe continues to expand. The movie is set to be released in the U.S. on May 5.
Welcome @PomKlementieff, AKA Mantis, to the @Guardians family! #GotGVol2Premiere pic.twitter.com/bKka9TDBX9— Marvel Entertainment (@Marvel) April 20, 2017
Director @JamesGunn and Yondu (Michael Rooker) take over the #GotGVol2Premiere NOW! Watch: https://t.co/vWhBLLoB8u pic.twitter.com/PycLkyhp2b— Marvel Entertainment (@Marvel) April 20, 2017
They're back. Obviously. The cast and crew of #GotGVol2 together at the #GotGVol2Premiere! pic.twitter.com/vpgNdROPot— Marvel Entertainment (@Marvel) April 20, 2017


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Atherosclerosis is a multifactorial disease that preferentially develops in specific regions in the arterial tree. This characteristic is mainly attributed to the unique pattern of hemodynamic shear stress in vivo. High laminar shear stress (LS) found in straight lumen exerts athero-protective effects. Low or oscillatory shear stress (OS) present in regions of lesser curvature and arterial bifurcations predisposes arterial intima to atherosclerosis. Shear stress-regulated endothelial function plays an important role in the process of atherosclerosis. Most in vitro research studies focusing on the molecular mechanisms of endothelial function are performed in endothelial cells (ECs) under cultured static (ST) condition. Some findings, however, are not recapitulated in subsequent translational studies, mostly likely due to the missing biomechanical milieu. Here, we profiled the whole transcriptome of primary human coronary arterial endothelial cells (HCAECs) under different shear stress conditions with RNA sequencing. Among 16,313 well-expressed genes, we detected 8,177 that were differentially expressed in OS vs. LS conditions and 9,369 in ST vs. LS conditions. Notably, only 1,618 were differentially expressed in OS vs. ST conditions. Hierarchical clustering of ECs demonstrated a strong similarity between ECs under OS and ST conditions at the transcriptome level. Subsequent pairwise heat mapping and principal component analysis gave further weight to the similarity. At the individual gene level, expressional analysis of representative well-known genes as well as novel genes showed a comparable amount at mRNA and protein levels in ECs under ST and OS conditions. In conclusion, the present work compared the whole transcriptome of HCAECs under different shear stress conditions at the transcriptome level as well as at the individual gene level. We found that cultured ECs are significantly different from those under LS conditions. Thus using cells under ST conditions is unlikely to elucidate endothelial physiology. Given the revealed high similarities of the endothelial transcriptome under OS and ST conditions, it may be helpful to understand the underlying mechanisms of OS-induced endothelial dysfunction from static cultured endothelial studies.
- endothelial cells
- RNA-seq
- shear stress
- transcriptome
- Copyright © 2016 the American Physiological Society
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Christina Rafano
Hi, I'm Christina. I was a nursing student; now I'm a nurse.
It's nice to meet you.
In the spring of 2010, my heart stopped for 25 seconds. I was taken into the hospital for an urgent pacemaker surgery when a voice came over the sound system. They said a biker had been hit by a car and the ambulance was on it's way to the hospital. He was rushed past my room, surrounded by nurses and doctors, and sent into operation. Several hours later, they finally came back. The doctor gathered his team right outside my room and said,
"That man is not alive because of me, he is alive because of you.
You all did great work today, he wouldn't be here without you."
The trajectory of my life changed.
I was going to become a nurse.
My nursing journey is dedicated to helping you be the hero of yours.
That doctor was right. It's not about me, it's about you. We need great nurses like these. You are going to save lives. You are going to provide comfort to patients in their darkest moments. You are going to be the one their family remembers. You are going to be a GREAT nurse. I am here to make that happen.


text:
ISRO Recruitment 2015: The Indian Space Research Organization has released notification for the recruitment of Assistant & Technician posts. The number of vacancies for these posts is 27. The ending date to apply for these posts is 02-11-2015. So all the interested persons can apply on or before the last date.
It releases the vacancies every year. This year also it has released the vacancies for Assistant & Technician posts. It is good news for those who are waiting for these posts. The persons can apply for this post before the last date after clearly going through the notification given. The candidates will get application forms from the official website. The interested and eligible persons can apply for these posts on or before the ending date. The starting date to apply for these posts is 12-10-2015 and ending date is 02-11-2015.
The other details like how to apply, selection process, salary details, vacancy details, fee details are given for the quick reference of the candidates. The persons can go through the information given below or they can visit the official website to go through the notification and may get all the details.
ISRO Recruitment 2015 Complete Details:
Vacancy Details:
The number of vacancies for these posts is 27.
Name of the Organization: Indian Space Research Organization
Number of Posts: 27
Age Limit:
The persons those who want to apply for this post must have age not more than 35 years.
Education Qualification:
The applicant must have completed B.Sc degree in Computer Science/ Information Technology or equivalent from any recognized university or Organization.
Selection Process:
The persons will be selected based on the written test and the personal Interview.
Salary Details:
The candidates those who got selected will be given a salary within a range of Rs. 9300 to Rs. 34800 with a Grade pay Rs. 4600 per month.
How to Apply:
The eligible candidates can apply in online through the official website on or before the last date.
Important Dates to Remember:
Start date to apply: 12-10-2015
Last date to apply: 02-11-2015
Official Website: http://www.isro.gov.in/


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|September 19, 2017
|8:30 am to 4:30 pm
|September 20, 2017
|8:30 am to 4:30 pm
|November 28, 2017
|8:30 am to 4:30 pm
|November 29, 2017
|8:30 am to 4:30 pm
|February 21, 2018
|8:30 am to 4:30 pm
|February 22, 2018
|8:30 am to 4:30 pm
This two-day course is the third in a series of courses targeted to meet the needs of science and policy professionals. It is an extension of and builds upon the Essentials of Science Policy course (Science in Government 201) with greater participant engagement on applying the fundamentals to strategy development. In this context "science in government" relates to all departments and all staff involved in science that supports:
Targeted Participants
Professionals at the senior officer level and at the first levels of executive responsibility in the following groups will be interested in this course:
"Science" – Federal scientists, engineers, researchers, regulatory experts and other technical professionals seeking to improve their understanding and skills related to the policy context for science and how to better ensure the relevance, quality and impact of their work.
"Policy" – Federal policy analysts/advisors and other officers in strategic planning, risk management, program delivery, knowledge management, audit, evaluation, communications, and other non-science professionals seeking to improve their understanding and skills related to how science can support evidence-based decision-making, provide a test bed for new ideas and improve their products.
"Science Policy" – Science policy analysts/advisors seeking to improve their understanding and skills related to science policy and their role at the interface between science and policy
Learning Objectives
By the end of the two-day course, participants will have:
Course Fee
The cost of this two-day course is $1200 (no HST) per person. The price includes expert facilitation, breakfast and lunch both days, and course materials.
IOG Promotion!
Discounts are available for multiple participants and/or if you choose to bundle the courses. Customized course offerings can be delivered on request for branches, teams or groups, in English or French, in any part of the country. Contact Toby Fyfe at firstname.lastname@example.com or at 613-562-0090 x242.
Registering is done through an online registration system where you can pay by credit card or request an invoice. If you have problems registering, please call 613-562-0090 x200.
The IOG value-added
All IOG courses are prepared and taught by those who have held senior positions in the federal government. They are guided by a Learning Committee of senior federal government public servants.
Quick Links


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OK to Bet, Just Not vs. Euro?
Can you organize a cabal in three and a half minutes?
That is roughly how long hedge-fund managers discussed shorting the euro for at an "ideas dinner" in New York last month, according to a person who was present. After the meeting was reported, the Justice Department asked attending hedge funds to retain records of any euro-related trades.
The evening's discussion lasted for about 145 minutes, according to the...


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Grandma's house used to be filled with ordinary people. People like you and me. She died a week ago, leaving behind a legacy as one of the finest mediums in all the county.
She gave comfort and reassurance to all those who suffered the vulnerability of lost loved one, even though my parents never quite believed it.
As requested, Grandma was cremated, and her ashes settled in a colourful jar atop the windowsill in view of her beloved garden.
Her video will though, requested one last, unsettling thing.
That her ashes be put into an oil lamp and be used as light.
Oddly enough, we obliged to this request, half-expecting the ashes to smother the flame and render our lamp useless.
We gathered around our kitchen table, I poured the ashes into the oil beneath. A flame quipped up, quite shockingly.
We took back everything we said about crazy ol' Grandma at that moment.
Her ashes burned a flame that raided the room with the grotesque faces of the undead. First tens. Then thousands. Swarming our home with their gaping mouths and their empty eyes. All surrounding, approaching the pebble of a flame dancing out the tip of the oil lamp.
Weeks on, the flame still burns, and we're all afraid to put it out.
Written by CrashingCymbal
Content is available under CC-BY-SA


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What type of activities did babywearing help you accomplish?
I liked having two hands to cook, wash dishes, chase after another child...and eventually type once we got a computer. I just liked having two hands again period! :)
What type of activities did babywearing help you accomplish? Or what type of activities do you like doing while babywearing?
Elise liked baby wearing like for 3 months, after that she hated it but during that time I could mop, wash clothes, cook, and vacuum.
I think babywearing is going to be essential for me... I need to have my hands for... well, pretty much everything, lol. It amazes me how much some moms can get done with only one arm.
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***Baby Team Leader Moms.com*** I have been married for over 20 years. My husband and I have eight children ages 18 down to 4 years old. We use to live in Chicago but now live in Canada. I own www.FaithandFamilyReviews.com.


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Author Tags: Literary Criticism, Poetry, Politics
Charles Doyle also writes as Mike Doyle. He is a New Zealander who was born in London, England of Irish descent. He came to Victoria in 1968 after a year in Connecticut, and became a longtime resident of Victoria where he taught at UVic, founding a little poetry magazine called Tuatara in 1969.
With Robert Sward, Doyle co-authored a chapbook called Quorum/Noah, published in Victoria in 1970. With P.K. Page he co-authored a chapbook called Planes in 1975. Although chiefly concerned with literature, and a poet, he co-edited two books on B.C. politics, The New Reality (1984) and After Bennett (1986).
Doyle's first poetry collection, A Splinter of Glass (1956), was published in New Zealand; his first Canadian collection is Earth Meditations (Coach House, 1971). Doyle reviewed for Canadian Literature from 1972 to the mid-1980s. As Charles Doyle he has written a biography of Richard Aldington and critical work on William Carlos Williams, Wallace Stevens, James K. Baxter and others.
Doyle has written about his own work as a writer by annotating a diary of his literary life from 1969 to 2006 in Paper Trombones: Notes on Poetics (Ekstasis 2007).
"As a sketchy memoir, it does not avoid a certain amount of ego-tripping and name-dropping; after all I haven't lived in a vacuum, but in a world where one must fend for oneself."
Some of the names dropped include Ted Hughes, Sylvia Plath, Robert Creeley, Lawrence Ferlinghetti, George Woodcock, Earle Birney, bill bissett and literally dozens of other fellow poets in Canada. Some of Doyle's observations of writers, offhandedly made at the time, gather historical weight with the passage of time. For instance, one entry made in 1974:
"Milton Acorn gave a 'performance' at UVic this midday. Anything more designed to discredit 'Canadian literature' can hardly be imagined. I've read I've Tasted My Blood and reviewed it with sympathy. Also contributed to the special award the poets got up for him. His face ugly, somewhat misshapen, has the high colour and rough texture of a boozer's. His eye glaucous, bloodshot, his teeth a mouthful of rotten discoloured stumps. He mumbled irrelevancies and stray remarks of a vaguely Maoist nature. Incoherent, deadly dull, nearly inaudible. I believe he 'performed' one poem at the end of an interminable dithyramble, but by then I had left. I had persuaded my first-year students to go hear him. Tomorrow, must offer humble apologies. Dorothy Livesay, under whose aegis he appeared, must have been embarrassed. Anyone would be."
Although Doyle's engaging comments made in the present-tense, as well as retrospectively, do provide glimpses of his personality, collectively they reveal that the task of becoming an established poet in any country has as much do with making mutually-supportive connections with other poets as it has to do with writing poetry.
Doyle retired in 1993 after 35 years as an academic but has continued to write. He once wrote, "I'm a poor self-publicist and there's a certain Zenlike satisfaction in nonentity."
In 2015, Doyle released his memoir, Floating Islands (Ekstasis) that recalls his Irish family background, his childhood and youth in London during the World War II, through the blitz. At age fourteen, he decided he wished to be a poet. As a high school dropout, he joined the British Royal Navy and was posted to Wellington, New Zealand. Two years later, his first serious poems were published in the quarterly Landfall. Doyle gained several degrees that landed him a lectureship at Auckland University.
His first poetry collection, A Splinter of Glass, received several awards, including a UNESCO Creative Artists Fellowship, which enabled him to spend months travelling
in the United States with the object of meeting American writers. A Fellowship of the American Council of Learned Societies enabled Doyle to spend a year as a visiting fellow in American Studies at Yale University, during which he wrote a book on the career of American poet William Carlos Williams and the book-length poem sequence, Earth Meditations, which later became his first Canadian book, published by Coach House Press, Toronto. Doyle has also received a PEN New Zealand award.
Review of the author's work by BC Studies:
After Bennett: A New Politics for British Columbia
A Splinter of Glass : Poems 1951-1955. Christchurch: Pegasus Press, 1956.
Distances : Poems. Auckland: Paul's Book Arcade, 1963.
Messages for Herod. Auckland: Collins, 1965.
Recent Poetry in New Zealand. Chosen and edited by Charles Doyle. Auckland: Collins, 1965.
A Sense of Place : Poems. Wellington: Wai-te-ata Press, 1965.
Small Prophets and Quick Returns: Reflections on New Zealand Poetry. Auckland: New Zealand Publishing Society, 1966.
Earth Meditations 2. Auckland: Charles Alldritt, 1968.
R.A.K. Mason. New York: Twayne Publishers, 1970.
Earth Meditations: One to Five. Illustrations by Jack Kidder. Toronto : Coach House Press, 1971.
Preparing for the Ark. Toronto: Weed Flower Press, 1973.
James K. Baxter. Boston: Twayne Publishers, 1976.
Stonedancer. Auckland: Auckland University Press ; Wellington : Oxford University Press, 1976.
William Carlos Williams: the Critical Heritag. Edited by Charles Doyle. London : Routledge & Kegan Paul, 1980.
William Carlos Williams and the American Poem. London: Macmillan, 1982.
A Steady Hand. Auckland: Auckland University Press, 1983.
The New Reality: The Politics of Restraint in British Columbia (New Star Books, 1984). Co-editor and contributor.
Wallace Stevens: the Critical Heritage. Edited by Charles Doyle. London ; Boston : Routledge & Kegan Paul, 1985.
After Bennett: A New Politics for B.C. (New Star Books, Vancouver 1986). Co-editor.
Richard Aldington: a Biography. Basingstoke, Hants. : Macmillan, 1989. Carbondale: Southern Illinois University Press, 1989.
The Urge to Raise Hats (Victoria, 1989)
Richard Aldington: Reappraisals. Edited by Charles Doyle. Victoria: English Literary Studies, University of Victoria, 1990.
Separate Fidelities (Victoria, 1991)
Intimate Absences: Selected Poems 1954-1992. Victoria: Beach Holme, 1993)
Where to Begin (Ekstasis, 2000)
Living Ginger (Ekstasis, 2004) - poetry
Paper Trombones: Notes on Poetics (Ekstasis, 2007).
The Watchmans Dance: Poems 2004-2009 (Ekstasis 2010) $21.95 - poetry
Collected Poems 1951-2009 (Ekstasis, 2011)
Echoes from Pluto: Poems 2009-2013 (Ekstasis 2014) $23.95 978-1-77171-004-6
Riding the Pig: more notes on poetics (Ekstasis 2014)
Floating Islands (Ekstasis 2015). $25.95
[BCBW 2015] "Poetry" "Literary Criticism" "Politics"
Paper Trombones: Notes on Poetics
Paper Trombones: Notes on Poetics by Mike Doyle (Ekstasis $19.95)
Time reduces history or magnifies it. Poet and UVic professor Mike Doyles annotated diary of his literary life in British Columbia since 1969, Paper Trombones: Notes on Poetics, is a rare magnifier for the lower Vancouver Island literary scene.
Some of Doyles observations of writers, offhandedly made at the time, gather historical weight due to their natural candour.
For instance, having favourably reviewed Milton Acorns Ive Tasted My Blood and contributed to a special award to honour Acorn, Doyle recorded a disastrous midday reading by Milton Acorn at UVic in 1974.
His face ugly, somewhat misshapen, has the high colour and rough texture of a boozers, Doyle writes. His eye glaucous, bloodshot, his teeth a mouthful of rotten discoloured stumps. He mumbled irrelevancies and stray remarks of a vaguely Maoist nature.
Incoherent, deadly dull, nearly inaudible. I believe he performed one poem at the end of an interminable dithyrambl, but by then I had left. I had persuaded my first-year students to go hear him. Tomorrow, must offer humble apologies. Dorothy Livesay, under whose aegis he appeared, must have been embarrassed. Anyone would be.
More sympathetically, Doyle offers a candid assessment of a wake for poet, critic and anthologist, Charles Red Lillard at the home of Robin Skelton in 1997. Again, it is the jotted down, fly-on-the-wall honesty of Doyles perspective that appeals.
The large Victoria Avenue house [was] full, he writes. [There were] many readers and speakers, including George Payerle, Susan Musgrave, Theresa Kishkan and her husband John Pass, Marilyn Bowering, Patrick Lane, several of whom I like, though I am close to none. A moving occasion though some banal poetry. A bit of dopey by-play, celebrat-ing John Barleycorn, spitting into the wind.
Saw Diana Hayes, P.K. [Page], Phyllis Webb (all to talk with, I mean) and many others, including Rona Murray and Walter Dexter. For Charles sake, and Rhondas, Im glad this happened; there were plenty of tears. Charles, after all, was a good man, a nexus of good happenings in the writing community. Glad to be there, I liked him and he was helpful to my work.
Insofar as there is a community, I always feel on a remote edge. Rilke said, Love your loneliness; I do, for the most part. Charles will be missed, though, not least by me.
Some of the names dropped include Ted Hughes, Sylvia Plath, Allen Ginsberg, Robert Creeley, Lawrence Ferlinghetti, William Carlos Williams, George Woodcock, Earle Birney, bill bissett and literally dozens of other poets.
As a sketchy memoir, Doyle admits, it does not avoid a certain amount of ego-tripping and name-dropping; after all I havent lived in a vacuum, but in a world where one must fend for oneself. 978-1-897430-05-7
[BCBW 2008] "Poetry"