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trading opzioni binarie cos/////\\\\\\'è Research from Brazil has identified women as having significantly more cells in their olfactory bulbs. The authors are careful not to suggest a simple 'more cells equals better at smelling' conclusion but it is hard to resist making inferences given some of the male dominated discourses around wine tasting…
best binary option signals 2017 Sex differences in the human olfactory function reportedly exist for olfactory sensitivity, odorant identification and memory, and tasks in which odors are rated based on psychological features such as familiarity, intensity, pleasantness, and others. Which (sic) might be the neural bases for these behavioral differences? The number of cells in olfactory regions, and especially the number of neurons, may represent a more accurate indicator of the neural machinery than volume or weight, but besides gross volume measures of the human olfactory bulb, no systematic study of sex differences in the absolute number of cells has yet been undertaken. In this work, we investigate a possible sexual dimorphism in the olfactory bulb, by quantifying postmortem material from 7 men and 11 women (ages 55–94 years) with the isotropic fractionator, an unbiased and accurate method to estimate absolute cell numbers in brain regions. Female bulbs weighed 0.132 g in average, while male bulbs weighed 0.137 g, a non-significant difference; however, the total number of cells was 16.2 million in females, and 9.2 million in males, a significant difference of 43.2%. The number of neurons in females reached 6.9 million, being no more than 3.5 million in males, a difference of 49.3%. The number of non-neuronal cells also proved higher in women than in men: 9.3 million and 5.7 million, respectively, a significant difference of 38.7%. The same differences remained when corrected for mass. Results demonstrate a sex-related difference in the absolute number of total, neuronal and non-neuronal cells, favoring women by 40–50%. It is conceivable that these differences in quantitative cellularity may have functional impact, albeit difficult to infer how exactly this would be, without knowing the specific circuits cells make. However, the reported advantage of women as compared to men may stimulate future work on sex dimorphism of synaptic microcircuitry in the olfactory bulb.
الخيارات الثنائية تجريبي دون حساب Oliveira-Pinto AV, Santos RM, Coutinho RA, Oliveira LM, Santos GB, et al. (2014) Sexual Dimorphism in the Human Olfactory Bulb: Females Have More Neurons and Glial Cells than Males. PLoS ONE 9(11): e111733. doi:10.1371/journal.pone.0111733
buy cytotec 200 mcg in Corpus Christi Texas Full paper can be read (here)
http://www.selectservices.co.uk/?propeler=piattaforme-trading-opzioni-binarie&5d5=b7 piattaforme trading opzioni binarie By mthomas
Pretty good evidence that we all live in different smell/taste universes can be found here. The study, from Hiroaki Matsunami (Associate Professor of molecular genetics and microbiology) and colleagues, shows that a single amino acid encoded on one gene can mean a person finds a certain smell pleasant whilst others dislike it. They state; "We found that individuals can be very different at the receptor levels, meaning that when we smell something, the receptors that are activated can be very different (from one person to the next) depending on your genome." Preference is individual and trends or patterns of activation would be of great interest to companies wanting to pitch products to consumers. However, beyond our tendency to like or dislike a smell, we are pretty limited in terms of our ability to discriminate between them. There appear to be ten basic smell attributes according to Jason Castro and colleagues. These are contextual and involve learning so our preferences are only the start of the story. How we describe the smells we are reacting to is another thing entirely.
Castro J, Ramanathan A, Chennubhotla C. (2013) Categorical Dimensions of Human Odor Descriptor Space Revealed by Non-Negative Matrix Factorization. PLoS ONE.
Mainland J, Keller A, Li Y. et al (2013) The missense of smell: functional variability in the human odorant receptor repertoire. Nature. 2014
On a related topic I have just got a copy of Charles Spence's new book The Perfect Meal and will review it soon
Building on my last post (on student drinking) here is a link to some papers presented at the recent BPS conference. abstracts
Interesting findings from researchers at Northumbria and Sussex Unis include;
Students who engage in sports tend to be more hazardous in their drinking than the general student population but hazardous drinkers who participated in sport reported better cognitive functioning than hazardous drinkers who did not participate in sport. So the various sports clubs at Uni may be populated by hazardous drinkers (perhaps predisposed to binging and/or bingers due to the social context of sports clubs) but their sporting activities may provide a bit of protection against the cognitive effects of booze.
Hazardous drinking students reported lower scores on a measure of psychological well-being compared to non-hazardous drinkers. This contradicts the results of an American student survey.
Non-drinkers are perceived to be less favourable and sociable relative to regular drinkers, with this perception being strongest among heavier drinkers. Interventions that challenge these negative perceptions of non-drinkers (i.e. that they are less sociable) may lead to a reduction in undergraduate's alcohol consumption.
A new initiative from the NUS (supported by the Home Office) is seeking to address problem drinking in UK Universities. The aim is to develop a new accreditation mark for a whole-institution approach to responsible alcohol consumption. It is interesting to note that it is 'underpinned by social change theory' and focuses on promoting a culture of responsible drinking. To do this institutions need to meet criteria such as publishing a high-level statement on responsible alcohol consumption, restricting on/around-campus advertising and running awareness events.
One interesting 'nudgy' strategy is the need to evidence the promotion of a 'cafe-culture'. Presumably this will emphasise herb teas and intellectual debate rather than binging on sugar saturated caramel frappuccinos and caffeine drenched fizz. It is good to see oppressive alcohol fuelled initiation rites being challenged in an informed and non-punitive manner. At the moment seven Unis are subscribed to the pilot but I expect many more to follow suit in future.
Link to the project website here for more info.
Robert Johnson continues his systematic critique of judge's consistency in wine competitions in characteristic style in a paper just published in the Journal of Wine Economics. It is based on findings from his statistical analysis of medals awarded by judges across competitions in the US (which demonstrates correlations not dissimilar to fish predicting financial markets). He proposes criteria for evaluating and accrediting judges many would welcome, but some may not! The abstract follows;
A test for evaluating wine judge performance is developed. The test is based on the premise that an expert wine judge will award similar scores to an identical wine. The definition of "similar" is parameterized to include varying numbers of adjacent awards on an ordinal scale, from No Award to Gold. For each index of similarity, a probability distribution is developed to determine the likelihood that a judge might pass the test by chance alone. When the test is applied to the results from a major wine competition, few judges pass the test. Of greater interest is that many judges who fail the test have vast professional experience in the wine industry. This leads to us to question the basic premise that experts are able to provide consistent evaluations in wine competitions and, hence, that wine competitions do not provide reliable recommendations of wine quality.
I guess there a few obvious criticisms that can be levelled, such as the idea that wines will 'show' identically across competitions. However, the fundamental notion that judges should demonstrate consistency if awards are to be viewed as meaningful is pretty unassailable. His empirical evidence, that even with vast experience they tend not to, somewhat undermines confidence in all those medals plonked on labels.
Johnson, R. and Jing, c. (2014 ) Criteria for Accrediting Expert Wine Judges Journal of Wine Economics Vol 9 No. 1 p62-74
A slightly more philosophical/polemic piece on wine expertise in the light of 'the long tail hypothesis' by Arto Koskelo can be found here
I recently visited Plumpton Agriculture College for a tour of the excellent Wine Centre. It was also a bit of a nostalgic trip because my mum worked there in the 70s and, as a small child, I used to go to all the open days. It has come on a lot since then and is now recognised as an outstanding wine education centre with an expanding curriculum on offer. What they teach goes beyond a focus on production and increasingly includes the business end of the wine trade.
Of particular note is the Wine Consumer Behaviour module which is part of the Wine business BA. It has the following learning outcomes for students;
1. Apply theoretical consumer behaviour models to practical wine applications
2. Demonstrate an ability to understand the psychological structures and processes involved in wine consumer choice
3. Provide a critical analysis of the literature on determinants of wine consumer choice.
This innovative course is run by Paul Harley (far right) who kindly showed Dr Paul Curran, who writes about wine and health, (pictured right) and me around the impressive facilities. These include state of the art labs and an excellent bespoke tasting room. Paul (H) is passionate about psychology and I hope to contribute to the course in future.
It would have been a shame not to pick up some of the wines produced at Plumpton and Paul (C) and I both 'plumped' for one of the sparkling wines they produce there; opzioni binerie The Dean (Brut NV) £22. An IWC silver medal winner in 2012 and likely to win more plaudits in future. It is crisp and refreshing with enough complexity to make you want to go back to it after the first glass. This and a visit to Ridgeview later in the day confirmed my view that Sussex will deservedly increase its cut of Champagne's market over the next decade.
The website is here if you want to look at the courses on offer, visit or buy wine.
The work of two of my favourite psychologists, DanielKahneman (alive and thriving) and Amos Tversky (1937-1996) was featured on Horizon this week. The programme explored their Nobel prize winning work which showed that we have two decision making systems; one is fast and intuitive whilst the other is slow and logical. We mostly rely on the former and it is very unreliable. For example, people can be primed with information (a 'meaningless number') to pay more or less for a bottle of Champagne. This is because we make our way through our complex world using heuristics (rules of thumb) and these are riddled with biases. Heuristics are necessary because our ability to process information is limited and our world would be overwhelming if we didn't have some quick ways to deal with events and choices (such as selecting a wine from hundreds in a supermarket). Watch the programme to see how they created behavioural economics which is redefining how our financial and intelligence systems are designed. Perhaps also reflect on wine purchases which tend to be about risk management, familiarity, labels and emotional states rather than laboured logical decision making.
Lovely grower champagne from Marguet (made by Benoit Bonnerave 5th generation maker based in Ambonnay) care of the Wine Society. Its an elegant Blanc de Noirs (78% pinot noir and 22% pinot meunier). Unsurprisingly, given the black grape content, it's slightly austere and less floral than most fizz. It does have some really subtle russet apple flavours underneath its initially quite 'manly' (sic) style.
This is a pleasure on its own but magical with a hard cheese. It's seriously good stuff that knocks the spots of some equivalent price big brands. The Wine Society keep rooting out gems like this and I am gradually working my way through their range of grower champagnes because the quality is consistently high and there is wonderful variety amongst the range. This would be a great place to start;
binäre optionen handeln steuern Champagne Marguet Blanc de Noirs The Wine Society £22
I have been very George Clooney towards social media in 2014; neglecting my blog, twitter etc. etc. ad nauseum and 'doing stuff' instead. However, the latest issue of the Journal of Wine Economics here has a few papers that might be of interest.
One telling contribution, a paper from Orley Ashenfelter and Gregory V. Jones, suggests that the demand for 'expert opinion' on wines from Bordeaux is not just about a thirst for accurate information. The abstract is below;
In this paper, we use unique data from the market for Bordeaux wine to test the hypothesis that consumers are willing to pay for expert opinion because it is accurate. Using proprietary indicators of the quality of the vintage, which are based on both publicly and privately available information, we find that additional publicly available information on the weather improves the expert's predictions of subsequent prices. This establishes that the expert opinions are not efficient, in the sense that they can be easily improved, and that these opinions must be demanded, at least in part, for some purpose other than their accuracy.
Yet more evidence of the prevalence of pundits wearing 'Emperor's new clothes' and charging punters for the pleasure of admiring them.


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Creamy Apricot Oatmeal - Volumetrics
READY IN: 10mins
Recipe by Sumisan
"energy density" of .90
Top Review by KeleKooks
Was leafing through recipes looking to ways to use the box of dried apricots sitting in the cupboard and i found this. Great breakfast!Very satisfying. I added a tad of cinnamon to my bowl also. Great to find healthy meals that taste great!Also i sweetened with pure maple syrup instead of brown sugar. Yum!!! Thanks!!!
Ingredients Nutrition
- 1 1⁄2 cups quick-cooking rolled oats
- 4 cups nonfat milk
- 1⁄2 teaspoon grated nutmeg
- 4 tablespoons oat bran
- 10 finely chopped dried apricots, about 2 oz
- 2 tablespoons brown sugar
Directions See How It's Made
- Combine the oats and 3 cups milk in a medium saucepan.
- Bring the mixture to a boil .
- mix in nutmeg and oat bran.
- Reduce heat and simmer, stirring for about 1 minute.
- Divide among 4 bowls.
- Sprinkle with apricots and brown sugar.
- Serve with remaining milk on the side to mix in if desired.

subset: commoncrawl


text:
Animal Crossing: Three Towns is an Xbox One game. The game even uses Xbox Live.
- Normal (Male & Female)
- Cranky (Male)
- Lazy (Male)
- Jock (Male)
- Smug (Male)
- Snooty (Female)
- Peppy (Female)
- Uchi (Female)
Starter Villagers
You start with 8 villagers. One of each type, Besides smug. You can get up to 17 (19 if you count campers)
Once you have 14 villagers (13 in Japanese), gone will try to move out. There is 80% chance they will. Sometimes, they will delays the move by 27 (28 in American) days, then they leave no matter what. Next, there will be 1 or 2 people that will visit for a day. They can sell items that are rare. Also, villagers celebrate holidays, each in a different area. Such as how Thanksgiving is celebrated at the beach. See the more info section for the whole list. When a player befriends a villager, they give you a gift for you. Example: Graham gives you a picture that is signed by him. The whole list is in the more info area. Sometimes villagers (Beside lazy ones) will challenge you to catch the biggest fish is you have a fishing rod. If you sometimes talk to cranky or snooty villagers, they can possibly rumor about two villagers dating. There is still no proof though. Villagers walk the same pace as the player. Villagers play hide- and- seek with you still. Also, you can find 2-14 random villagers in the town and they talk about the glamour. Sadly, only peppy villagers are able to be persuaded into town. Also, normal villagers never appear. They water flowers and sit on stumps and benches. But lastly, they even read the bulletin board, say, you may need this. For the entire list of bulletin board ads, look in the more info area.
- House (Player & Villagers)
- Nook's Homes
- T&T Shack
- T&T Shack 2.0 (Get after T&T Shack has been opened for a week minimum and you have bought $10,000 of items there)
- T&T's Amazing House (
More Info
Celebration Locations: Celebration Locations in Animal Crossing: Three Towns
Friendship Gifts: Friendship Gifts in Animal Crossing: Three Towns
Bulletin Board Ads: Bulletin Board Ads in Animal Crossing: Three Towns
Added Features In The Nookling Shops: Added Stuff in Nookling Stores in Animal Crossing: Three Towns


text: "HIPAA is not what it is made out to be. Nurses must use caution and professional judgement, but we need not gag ourselves into complete silence. If we discuss a patient or situation in such a way that no one without their own inside knowledge could know with certainty who it is, it is not a HIPAA violation!"


text:
(The Hosting News) – Customers of Switzerland's largest web host Hostpoint will now have the ability to use popular website building solution CM4all integrated within their web services, CM4all's creator Content Management AG announced on Monday.
By providing easy website content creation, CM4all's solution allows users to make use of "drag & drop" functionality along with other features including widgets.
The availability of CM4all Sites builds on a seven year agreement between HostPoint and Content Management AG.
Discussing the matter in a press release, Hostpoint Chief Customer Officer Yvan Knapp stated, "We are convinced that thanks to CM4all Sites, we now have the opportunity to create a truly integrated homepage product and deliver the functionality that users want in a well designed and tested user interface that all of them can actually use."
"It goes without saying that we will make our new solution available to all Swiss customers from day one no matter which languages they speak and which one they prefer," Knapp continued.
Meanwhile, users can access the service via an extra monthly fee available at two prices.
Among its hosting services, HostPoint provides managed services, domains, web hosting, e-commerce, and more. Partners of the web provider include HP, Sun Microsystems, data center operator interxion, and more.
Earlier this year, in August, Content Management AG launched a reseller version of CM4All at annual hosting conference HostingCon (held in San Diego, California). Based in Cologne, Germany and founded in 1999, the company's various products include features such as design templates, security, and more.
Previous web hosting providers to announce CM4All implementation have included the UK2Group and Binero. For more information regarding the matter, view a press release by Content Management AG here (cm4all.com).


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
Can I make 2 different forms go on to the same spreadsheet?Asked by brandonppr on September 28, 2016 at 03:26 PM
I need different forms to go to the same spreadsheet. Is that possible?
JotForm Support
There is a JotForm app that will allow you to combine submission data of up to 2 forms.
The Combine Submissions App does this.
The output data of the submission app is a CSV data file format. You can just import the CSV data into your spreadsheet using import function.
If you were using the Google Spreadsheet integration on your forms, the integration will create individual spreadsheet for each form/s that uses the integration.
What you may want to check instead is to consolidate each of the google spreadsheet data into a single/same spreadsheet. Google docs have this function called IMPORT Range which does the consolidation.
You can refer to this guide from Google docs.
Hope this help. Let us know how it goes.


text:
After playing a Kashmiri girl in Haider, Shraddha Kapoor will be seen adorning a very different avatar this time around for a brand shoot.
Be it films, the red carpet, magazine covers or her brands, Shraddha keeps trying to change her look.
As she turns brand ambassador for Lakme Lip Love, yet once again she is seen trying to get into a different look.
Sources close to Shraddha share that she really likes the fringe look and is contemplating to actually get one herself.
Copyright © ClapsnSlaps, Inc 2017.
SBB Venture Pvt. Ltd. All rights reserved.
The content on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of clapsnslaps.com


text:
Evaluation of Pemetrexed Combined With Cisplatin and Radiotherapy for Unresectable Locally Advanced Non-Small Cell Lung Cancer (NSCLC) (PACCORA)
This study has been completed.
University Hospital, Antwerp
Universiteit Antwerpen
Eli Lilly and Company
Information provided by:
University Hospital, Antwerp
ClinicalTrials.gov Identifier:
First received: July 4, 2007
Last updated: April 9, 2009
Last verified: April 2009
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The aim of this study is to evaluate if the multi modality treatment pemetrexed combined with cisplatin and radiotherapy can lead to a better tumor control and/or a better side-effect profile in patients with locally advanced NSCLC. Patients will be randomized between 3 cycles of induction chemotherapy followed by concurrent chemoradiotherapy or concurrent chemoradiotherapy followed by 3 cycles of adjuvant combination chemotherapy.
|Non-Small Cell Lung Cancer
|Drug: combination chemotherapy (pemetrexed + cisplatin) Radiation: thoracic irradiation + pemetrexed
|Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Randomized Multicenter Phase II Study Of Induction Therapy With Pemetrexed And Cisplatin Followed By Chemoradiation With Pemetrexed Versus Chemoradiation With Pemetrexed Followed By Consolidation Therapy With Pemetrexed And Cisplatin In Patients With Stage III Non-Small Cell Lung Cancer: Paccora Trial
Resource links provided by NLM:
Genetics Home Reference related topics: lung cancer
MedlinePlus related topics: Lung Cancer
Drug Information available for: Cisplatin Pemetrexed Pemetrexed disodiumU.S. FDA Resources
Further study details as provided by University Hospital, Antwerp:
Primary Outcome Measures:
- Response rate [ Time Frame: after each treatment modality and 5 year follow-up ]
Secondary Outcome Measures:
- Toxicity [ Time Frame: at the end of each cycle and 5 year follow-up ]
- Time to progression [ Time Frame: 5 year follow-up ]
- Overall survival [ Time Frame: median survival and 2-year survival ]
|Study Start Date:
|February 2006
|Study Completion Date:
|March 2009
|Primary Completion Date:
|March 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: A
pemetrexed + cisplatin (3 cycles) followed by thoracic irradiation + pemetrexed
Drug: combination chemotherapy (pemetrexed + cisplatin)
pemetrexed 500 mg/m2 + cisplatin 75 mg/m2 (q 3 weeks for 3 cycles)
Other Name: AlimtaRadiation: thoracic irradiation + pemetrexed
pemetrexed 500 mg/m2 (q 3weeks for 2 cycles), 60 GY (30 fractions of 2 GY)
Other Name: Alimta
Experimental: B
thoracic irradiation + pemetrexed followed by pemetrexed + cisplatin
Drug: combination chemotherapy (pemetrexed + cisplatin)
pemetrexed 500 mg/m2 + cisplatin 75 mg/m2 (q 3 weeks for 3 cycles)
Other Name: AlimtaRadiation: thoracic irradiation + pemetrexed
pemetrexed 500 mg/m2 (q 3weeks for 2 cycles), 60 GY (30 fractions of 2 GY)
Other Name: Alimta
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- cytological or histological proven NSCLC
- unresectable stage III NSCLC
- presence of at least one measurable lesion (RECIST criteria)
- adequate haematological, renal and hepatic function
- adequate lung function reserve
- good condition, weight loss <10 % over previous 6 months, life expectancy > 3 months
Exclusion Criteria:
- previous chemo- or radiotherapy for NSCLC
- distant metastasis or a malignant pleural or pericardial effusion
- second active primary malignancy or serious concomitant medical disease
- interstitial lung disease
- auto-immune systemic disease with potential involvement of the lungs
- inability to interrupt aspirin or other non-steroidal anti-inflammatory agents for a 5-day period
- concomitant use of amiodarone
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00497315
Please refer to this study by its ClinicalTrials.gov identifier: NCT00497315
|ZNA Middelheim
|Antwerpen, Antwerp, Belgium, 2020
|University Hospital Antwerp
|Edegem, Antwerp, Belgium, 2650
|St Augustinus Ziekenhuis
|Wilrijk, Antwerp, Belgium, 2610
Sponsors and Collaborators
University Hospital, Antwerp
Universiteit Antwerpen
Eli Lilly and Company
|Principal Investigator:
|Paul R Germonpre, MD PhD
|Universiteit Antwerpen
More Information
Keywords provided by University Hospital, Antwerp:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 18, 2017
|Responsible Party:
|Thoracic Oncology Group Antwerp - Paul Germonpre, Thoracic Oncology Group Antwerp
|ClinicalTrials.gov Identifier:
|NCT00497315 History of Changes
|Other Study ID Numbers:
Eudra CT 2005-004030-40
|Study First Received:
|July 4, 2007
|Last Updated:
|April 9, 2009
Keywords provided by University Hospital, Antwerp:
Non-Small Cell Lung Cancer
locally advanced NSCLC
lung cancer
Additional relevant MeSH terms:
Lung Neoplasms
Carcinoma, Non-Small-Cell Lung
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Lung Diseases
Respiratory Tract Diseases
Carcinoma, Bronchogenic
Bronchial Neoplasms
Antineoplastic Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Folic Acid Antagonists
Nucleic Acid Synthesis Inhibitors
ClinicalTrials.gov processed this record on August 18, 2017


text:
I am trying to setup a Samsung Jack with Windows Mobile 6.5 to ActiveSync to our new 2010 Exchange Server. We use a self-signed certificate and all other types of phones; iPhones, Androids, etc.. all worked without a hitch. The one phone I thought would be a cinch to sync, the Microsoft one is a no go.
I am getting a 85030027 error code when I try to sync. This usually means the iis server is setup to allow client certificates. But this is not the case the iis server is actually setup to ignore client certificates, so it should not have this error but it does.
I have physically installed the self-signed exchange server to the trusted root folder of the phone.
I have exhaustively searched Google and tried EVERYTHING I could find to no avail.
I am hoping someone has a definitive answer to my conundrum.
5 Replies
Apr 19, 2011 at 5:28 UTC
since your other phones etc work
i would suspect it is a bad config on the phone?
hard wipe it and start over(unless you have tried this already)
post if you have or not tried that option(kinda drastic)
Apr 19, 2011 at 5:55 UTC
Just a thought, does the Exchange Server have any certificates? WinMo6.5 I think requires the security certificate to be loaded on to the phone and then connect to the Exchange.
Apr 20, 2011 at 9:09 UTC
Does WM6.5 allow self-signed certs? I remember it being pretty particular with certs when I had one. Even signed wildcard certs (we use them) from a vendor were a pain.
Apr 20, 2011 at 9:18 UTC
@ RjD I did wipe the phone. It had 6.1 and I upgraded it to 6.5.
@ Barry Yes, I copied the self-signed cert to the phone and installed it, verified that it was in the root folder.
@ Michael That is a good question. I would venture to say it could be the issue. I guess I need to verify if I can even use self-signed certs. Why does Microsoft ALWAYS have to do things the hard way?
Apr 20, 2011 at 9:22 UTC
@ Michael That is a good question. I would venture to say it could be the issue. I guess I need to verify if I can even use self-signed certs. Why does Microsoft ALWAYS have to do things the hard way?
I ask that question every day. |:|
This discussion has been inactive for over a year.
You may get a better answer to your question by starting a new discussion.


text:
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text:
Hello and welcome to my homepage!
I am an electronic engineer, Wikipedian since July 2002, and ever since the 1970s I have been busy with microprocessors, designing micropocessor based electronic equipment. In fact, in 1980 or so, I designed one of the first Dutch Microcomputers, called the ASTER CT-80. It was a TRS-80 clone, that could also run CP/M. Since then I have been interested in the history of computers. I own an extensive library with German, Dutch, British and American computer magazines. For example an (almost) complete complete collection of BYTE magazine. I also collect old homecomputers of which I have between 80 and 90 (I lost count), with my oldest computer being a Datapoint 2200, which is considered the oldest system that can be considered a Personal Computer, and which CPU architecture has Insipred the architecture of Intels first 8-bit CPU, the Intel 8008. A CPU architecture which Successors are still used in the CPU's of all PC's (and now Mac's too).
Some of the articles I created[edit]
Listed in order of addition, last addition on top
- Durango F85
- CCE MC-1000 later the separate articles I wrote about the GEM 1000 and Rabbit RX83 were merged with this one, as they proved to be too obscure to have their own article :-)
- Sony SMC-70
- MUPID didn't have its own page, while it had an entry in my list of home computers by video hardware, so I created the page.
- VIDC1 & VIDC20 the video display controllers used in the Acorn Archimedes and RiscPC ARM based computers
- Arch Linux ARM the ARM version of Arch Linux
- Pin header was amazed to find this staple product of electronic devices had no entry in wikipedia
- DCEbus the I/O bus designed by DAI
- HB-F9P MSX2 computer for which I helped writing the built in application package memovision for SONY
- Text semigraphics and Semi graphical characters which were later merged together.
- Z-DOS from a redirect page
- V.23 from a redirect page
- Sinclair X-1
- Mi2 (console)
- Cloud (operating system)
- Skytone Alpha-400 The worlds cheapest 7" screen mini notebook at €130
- The Brew (band)
- People's Computer Company
- Home computer remakes and its category page [1]
- Experiment-s
- Linpus Linux
- Electronics today international (magazine)
- Elektor Junior Computer I hand-build dozens of these to be sold commercially, I also built half a dozen Acorn Atom machines for the same reason.
- GOS (operating system)
- Influence of the IBM-PC on the PC market first started as mainly a list in Personal computers, (which I also mostly wrote) later split off to become an article about this topic.
- Nuna4 and Twente One Dutch Solar cars in 2007.
- List of MSX compatible computers and an example the NMS-8250.
- List of MSX emulators.
- Actus formalis defectionis ab Ecclesia catholica translated from Dutch article.
- List of Apple II clones and List of TRS-80 clones
- Xbox 360 disk scratching problems Investigated and massively expanded this part of the article about Xbox 360 hardware problems.
- MSX-DOS about the disk operating system for MSX standard home computers.
- List of microprocessor development boards about systems such as the KIM-1 and motorola MEK6800D2
- Panasonic JR-200, a rare home computer, one of a very few systems to use a 6802 processor.
- 1chipMSX about the return of MSX home computers. Programming FPGA's in VHDL anyone?
- Mega Duck/Cougar Boy Just two rare Handheld game consoles I have recently acquired. I now also took a picture of them, and placed it in the article. I also wrote an article about "Watara Supervision internals" and a similar article "Mega Duck internals" so you can see the similarity of both designs. These pages have since been removed from wikipedia main because they were deemed to be "not encyclopedic", but the pictures I took for these articles can still be found here User talk:Mahjongg/Mega Duck Internals.
- Parallax Propeller, The most interesting Micro-controller I have seen in a long time (upgraded from the stub).
- List of home computers by video hardware What had gotten into me to take on this Herculean task I don't know, but this has been a major job (I loved to do), it's almost finished now (as long a no new systems/info show up).
- Video Display Controller is a subject that's near to my heart, it indirectly lead me to start on the "List of home computers by video hardware" article.....
- Comx-35 Still don't have found one for my collection, (I own about 80, I lost count, home computers and game systems) but I remember these.
- Kilobaud Microcomputing (magazine)'s are part of my extensive collection of home computer magazines. I liked them because of all the Schematics in them.
- Electronics today international (magazine) is another very old magazine that very early published designs of Home brew computers. I remember the "system 68", it did not have a keyboard or any other input device, you could only use a lightpen to turn on pixels (memory bits) on and off, and to start your program. That is in the time that everybody else used a switch-panel and led's, like the Altair. A very odd system! Maybe Ill write an article about it someday.
- So, I like obscure old home computers, the PSI Comp 80 (computer) is certainly one.
- The DAI Personal Computer was another one, from our friendly neighbour country. It died an un-deserved early death, but had great potential.
- Talkie tapes a funny way to store audio.
- List of edible fish (removed) and Barnevelder are from the time that I was organizing Category Lists_of_foods.
- Logic family is about the different kind of digital logic families, like TTL logic, the current article still resembles my starter.
- Visual thinking I wrote shortly after I discovered I am a "picture-thinker" myself, I think I did not even have a user page here.
I did much more, and older stuff, (the oldest may well be the article about my Aster CT-80) but I have to stop somewhere with this list.


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Cavenham Ploughhistorical era: mid 20th century
closed 1969
The Street
grid reference TL 760 703Something we've got wrong about this establishment? Something more you think we should know about it? Please email us
listed building grade II
View in Google Earth
CAMRA West Suffolk & Borders branch.
last updated 19/06/2017
The building dates from the 16th century.
(Most pub, location & historic details collated by Nigel, Tony or Keith - original sources are credited)


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Icebergs from glaciers display alarming signs of
increased melt and flow rate in Greenland.
© Nick Cobbing / Greenpeace
Greenpeace pressures the federal government and mobilizes Canadians to demand action on climate change. We have developed a comprehensive Energy [R]evolution for Canada that outlines a green energy future that challenges this country's current destructive energy scenario. Become part of the Canadian Energy [R]evolution and fight climate change by supporting renewable energy.
Climate change is a reality, and it's caused by human activity: the burning of fossil fuels. Climate change has a serious effect on the environment and people. Experts estimate hundreds of thousands of people die annually from the effects of climate change. Global warming causes glaciers to melt, sea levels to rise, extreme weather and habitat loss.
Climate scientists agree that global greenhouse gas emissions must peak by 2015 and then drop significantly to keep the increase in the average global temperature to less than 2 degrees C and avoid catastrophic climate change.
Indigenous peoples and local communities are at the heart of the fight against climate change and environmental destruction. When a new mine breaks ground, when land is grabbed, or when industrial loggers raze forests, they are the...
This month the fate of a Russian jewel will be decided in a small town in Western Siberia. The town is Beloyarsky and the jewel is the Numto nature preserve. The oil company Surgutneftegas already extracts oil from the park but now...
Last week, the Montreal Metropolitan Community (MMC) came out and stated its unanimous opposition to the Energy East tarsands pipeline . The MMC's denial was on behalf of 82 municipalities, including Montreal, Laval, Longueuil, and 79...
The road to justice is a long one.
I wish it weren't so but as the dust settles on COP21 we know that while historic steps have been taken, the demands of justice are still unfulfilled.
On the one hand, we now have a truly global...
The night of Alberta's historic announcement of a 100 MT cap on tar sands emissions, I breathed a sigh of relief - the days of the endless expansion of the tar sands were over. The tar sands finally had their limit.
The next morning...
41 - 45 of 403 results.


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Which Gumpaste Mix Or Ready To Use?
Decorating By sugarcheryl Updated 19 Aug 2008 , 1:38am by sugarcheryl
I was wondering which gumpaste mix do you prefer? Make your own or buy already made? and which brand?
Nick Lodge's recipe if I'm going to make it or his readymade if not. I'm currently testing Marcela Sanchez' ready made but it is really expensive. Satin Ice does not harden well for me. (I also like Wilton's ready made and I can buy it locally.)
I tried the Wiltons mix, didn't care for it. Right now I make my own from one of the recipes here. Nicholas Lodges gumpaste gets rave reviews from most people. I am going to try it as soon as my Tylose powder comes in.
I use the Wilton Gum paste mix more often than the ready-to-use, I like the texture better of the mix. It also doesn't dry out as quick while it is stored.
I haven't used any other brand but Wilton.HTH
if i make it ... i make nicholas lodge recipe... it is on his site... if i buy premade... it is wilton brand... it is really nice.. satin ice brand is too soft for me.. but again there are others that like it... that is ok too... we all are different and we like different things... hth
When I took the gumpaste class we learned how to make our own, but I buy Wiltons pre-made. It works well for me I only use it for bows and flowers, things that won't be eaten. It costs about $7.00-$8.00 here in the Macon area. (coupons for Michaels or Hobby Lobby are a big help) I will be making some gerbera daisies and roses this week for a wedding next weekend.
I've used both Wilton and Satin Ice ready-to-use. I have been happy with them both.
I have used wilton, satin ice, and bakel's (sp?) ready made, I like them all. Wilton dries fast compared to the other two, and is more expensive. I just bought some CK mix but haven't tried it yet. The bakel's runs 2.25 for a 1 lb. package.
Thanks everyone for your input. I use Wilton and I've made my own also. I was just wondering.
Can any one tell me is gum paste (wilton mix) edible? I mixed it with MMF and want to know if I need to tell people not to eat it!?
I just bought the wilton gumpaste mix... how much powered sugar do you use after mixing.. you know when your kneading it... Is the gumpast suppose to be sticky? or is the consistency suppose to be like fondant?
Sorry for snagging your post..
TIA, Charleen
You can eat gumpaste but it's hard and rather tasteless. And if you put wires in it It's definately NOT edible.
It is sticky at first you just have to work the powered sugar in and will become unsticky.


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Born in 1958 - United Kingdom
Born in 1958 in London, Tim Flach is a world famous photographer working especially in animal photography. He is a typical example of the photographer and reporter who achieved recognition in the artistic photography world. He has also written three books: ?Equus?, ?Dogs Gods? and ?More than Human?.
A graduate of the North East London Polytechnic and of Saint Martin's School of Art, he has been working independently since 1983. He is an official photographer for the Sunday Times, the Cirque du Soleil, Sony, Hermès and the Locarno International Film Festival. Two of his pieces became postage stamps in 2000.
His work is marked by a search of anthropomorphism that goes beyond the traditional animal portrait. He is fascinated by the tendency of ?humanizing? animal images.
"More than Human", Osbourne Samuel Gallery, London (UK)
"Dogs Gods", Fotoloft Gallery, Moscow (Russia)
International Photography Festival, Pingyao (China)
"The Horse", Goodwood House, West Sussex (UK)
"Dogs Gods", Bailly Contemporain, Paris (France)
"Dogs Gods", Dubinsky Fine Arts, Zurich (Switzerland)
"Into the Deep", Edinburgh Science Festival (UK)
"Horses of the World", Palais Impérial, Compiègne (France)
"The Horse in Art", The Summerfield Gallery, Cheltenham (UK)
"Dogs Gods", Lucy Bell Gallery, St Leonard's on Sea (UK)
"Dogs Gods", Osbourne Samuel Gallery, London (UK)
"Le Bestiaire Imaginaire", Palais Lumière, Evian (France)
"Equus II", Kentucky Museum of Art (USA)
"Equus", Artspace Gallery, London (UK)
"Equus", Crane Kalman, Brighton (UK)
Federation Equestrian International Charity, Kuala Lumpur (Malaisya)
Wafi Mall – Al Noor Charity (Dubai)
The 7th Heng Dian Cup International Photography Exhibition, Shanghai (China)
The Heng Dian, Jiang Su (China)
Citadel, Berlin (Germany)
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After serving as understudy to one of the greatest sopranos of our time, Melissa Citro is ready to break out on her own.
For the first time in her 15-year opera career, Citro will be singing the title role in this weekend's performances of Antonin Dvorak's "Rusalka" at the Mahalia Jackson Theater for the Performing Arts.
In the spring, she served as understudy in the role for Renee Fleming at the New York Metropolitan Opera, waiting patiently for a chance that never came. Fleming didn't miss a single performance.
Presented by the New Orleans Opera Association, "Rusalka" will be given its New Orleans premiere on Friday evening and Sunday afternoon. The work will be sung in Czech, with English translations.
"Learning 'Rusalka' this year has been a real pleasure because it's the most famous and possibly the greatest of all Czech operas," said Citro, who specializes in Czech and German opera. "It would be a great first opera for someone who's never been to one. The music is just so gorgeous, and the story is so interesting and timeless."
The story line of "Rusalka" will seem familiar to those who love "The Little Mermaid." Composed in 1901 from a libretto by Jaroslav Kvapil, "Rusalka" is the story of a water nymph who falls in love with a handsome prince and wishes to become human.
Despite warnings from the water gnome, Vodnik, that humans are evil, she refuses to be dissuaded and drinks a potion prepared for her by the witch Jezibaba.
However, the price she has to pay for becoming human is the loss of her voice. (Unlike the Disney version of "The Little Mermaid," this story doesn't have a happily-ever-after ending.)
The best-known piece in the opera is the Act I aria, "Song to the Moon," described as "one of the most sumptuous arias in all of opera" by Robert Lyall, New Orleans Opera's general and artistic director.
Lyall will be conducting the Louisiana Philharmonic Orchestra during both performances. The aria is Rusalka's plaintive plea for the moon to tell the prince of her love. "It's such a beautiful song with a gorgeous melody and universal appeal," Citro noted, "but so is the rest of the opera. The entire score is full of music that is just so rich and beautiful and thrilling to listen to."
Commenting on her proficiency in the challenging Czech tongue, Citro observed, "It's a really nice language to sing in. The vowels are very similar to those in Italian and once you get the hang of the tricky consonant combinations, it's a pleasure to sing in Czech."
Over her career Citro has also carved out a niche in the German opera repertoire, especially those composed by Richard Wagner. She has sung the entire, four-opera "Ring Cycle" in nearly every soprano role except that of Brunhilde.
"By happenstance, actually, I've been working so much in German and Czech that one thing led to another and that thing became a specialty," Citro noted.
Also in the "Rusalka" cast are tenor A.J. Glueckert as the Prince, bass Raymond Aceto as Vodnik, mezzo-soprano Jill Grove as Jezibaba and soprano Kathleen Halm as the Foreign Princess. The three Wood-Sprites are Amanda McCarthy, Annie Halbert and Brindley McWhorter, and Taylor Miller is the Hunter.
William Murray directs the production, Gregory Schramel and Marjorie Hardwick choreograph the dance sequences and Carol Rausch coordinates the New Orleans Opera Chorus. The sets were designed by Murray and the recently deceased G. Alan Rusnak.


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
Do I have a statue of limitations on the time line of when I can swear out a complaint on a person who hit me with their car.
There is a difference in what the State does- the criminal case- and any claims you have for injuries or damages- the civil case. You have no control on the criminal case but can sue for damages for him hitting you.
The value of every civil claim is chiefly based on what injuries/losses you have and how we prove them. Value of injury claims is based on medical bills, nature of permanent injury, and/or surgery, whereas property damage is based on replacement or market value of the item. These days the amount you can recover is also governed by the amount of insurance someone has and the amount of insurance you have because that a judgment over insurance proceeds rarely nets you anything they cannot bankrupt out of.
Essentially, insurance carriers try to negotiate every dollar they can, because every $100 means millions in the end to the Board of Directors. My recommendation is let an attorney handle this. I spent 8 years working for insurance companies and over a year working for the largest personal injury firm in the country before setting out to give clients personal service and help them fight these fights.
Even in soft tissue injuries, those tissues stretch and scar, or cause corresponding pressure on nerves in the spinal cord, leaving behind permanent problems for some. I have had clients need surgeries years later because of a bulging disk and have their entire world collapse for what seemed inconsequential at the time. Insurance companies want you to settle as soon as possible and treat as little as possible. Attorneys matter. They change their gameplan when a lawyer is involved.
For that reason - and the misinformation by TV lawyers and referral services- is why people should consult lawyers who take the time like on sites like this. Because of the economy, more lawyers are jumping into personal injury and should stick to what they know. Personal injury law REQUIRED knowledge about medical science and biomechanics (the forces on a body in a wreck) far greater and more specific than you'd think. The other side has doctors and millions on their side to say nothing is wrong or fight the claim. If you have any further questions, feel free to email me- email@example.com. Check out our website- www.knowthelawyer.com. We'd love to help you. Our number is 800-6-know-law. We are here to help.
Please CLICK the button if I HELPED or was BEST ANSWER. We also answer your questions on facebook- www.facebook.com/knowthelawyer, on twitter- @athleticslawyer and our radio show, Courts & Sports, on WOKV. Please like or follow us. No attorney-client relationship is established and responses here are general first impressions. You should consult with a lawyer about your problems. More about our firm is located at www.knowthelawyer.com.Ask a similar question
If it was a hit and run then you should call the police ASAP and report it. If you were injured and want to sue, then it is my understanding that you have 4 years from the date of injury to settle or file a lawsuit. You may want to confirm this with Florida counsel.
Good luck.
DISCLAIMER: David J. McCormick is licensed to practice law in the State of Wisconsin and this answer is being provided for informational purposes only because the laws of your jurisdiction may differ. This answer based on general legal principles and is not intended for the purpose of providing specific legal advice or opinions. Under no circumstances does this answer constitute the establishment of an attorney-client relationship.Ask a similar question
Candidly there some gaps in your question. However that said typically the statue limitations for car accident Florida is four years. However that can be increased or decreased depending on whether the cities involved or if you're suing your UIM. The most important thing that you do is that you pick up the phone and contact Atty. discuss your options. I'll be more happy to speak with you in detail regarding Your case if you would like
Legal Disclaimer: If this information has been helpful, please indicate below. Mr. Shiner is licensed to practice law in the State and Federal Courts of Florida. The response herein is not legal advice and does not create an attorney/client relationship. The response is in the form of legal education and is intended to provide general information about the matter within the question. Oftentimes the question does not include significant and important facts and time lines that, if known, could significantly change the reply and make it unsuitable. Mr. Shiner strongly advises the questioner to confer with an attorney in your state in order to ensure proper advice is received. To learn more about David I. Shiner or the Shiner Law Group, P.A. please call our office at (561) 368-3363 or toll free at 1 (855) 368-3363 or visit website at www.ShinerLawGroup.com or www.InCourt.comAsk a similar question
The statute of limitations in your state for suing for personal injury from a car accident is 4 years. Retain a car accident lawyer in your state from Avvo immediately. Good luck.
Licensed in PA & NJ. 29% Contingency Fee. Phone: 215-510-6755 www.InjuryLawyerPhiladelphia.comAsk a similar question
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In a musical reworking of Romeo And Juliet, 2nd in command for the Jets gang Tony falls in love with the sister of rival gang the Sharks' leader. Nobody approves, but nothing is going to keep these two apart. You just know it's going to end in tears.
In 1957, playwright Arthur Laurents collaborated with Bernstein, Sondheim and choreographer Jerome Robbins on West Side Story, a show that followed The Boys From Syracuse and Kiss Me Kate in wrestling a Shakespeare plot into a Broadway musical.
Laurent set Romeo And Juliet against a New York gang war straight out of the headlines. His Montagues are the Jets, the 'American' gang - though a few tossed-off insults suggest they're mostly Polish with token Irish and Italian members.
Certainly, the gangs they've already beaten (the Harps and the Emeralds) sound Irish. In place of the Capulets, West Side Story brings on the Sharks, sharp and resentful lads recently arrived from Puerto Rico, hotly eager to match any force thrown against them.
The lovers are Maria, innocent sister of Shark leader Bernardo, and Tony, co-founder of the Jets but lately drifting into the straight life - given how keen Riff is to get Tony back in the gang, it's not difficult to perceive a gay subtext - and the duels of Shakespeare become gang 'rumbles' with switchblades.
United Artists, evidently keen on cutting in on MGM's position as the natural home of Broadway musicals, bought up the rights and got the film out in 1961. It won the Best Picture Oscar and nine additional statuettes, including an unprecedented shared award for direction plus supporting actor and actress nods for George Chakiris (Bernardo, though he had played Riff on stage) and Rita Moreno (as Bernardo's girl, Anita).
Like most Best Picture Oscar winners, it's too big a production to be perfect and its greatness floats in with a fair amount of lesser stuff. Neither Richard Beymer (Tony) nor Natalie Wood (Maria) could handle the songs, so their singing voices come from Jimmy Bryant and Marni Nixon.
Both castings are compromises: Tony was offered to Elvis Presley, but Colonel Tom Parker, with typical disregard for his client's career opportunities, turned it down, relegating The King to nonsensical children's films. Could Tupelo's finest have played a New Yorker? If his Southern twang were controlled, Presley would have been a lot more convincing in the fight scenes. Wood, in nut-brown make-up and thick accent, is an appealing if not remotely Hispanic Maria.
A possible reason for the Colonel's rejection is that Tony doesn't even get the best numbers. And West Side Story has more hit songs in it than Chicago, Les Miserables and the entire Andrew Lloyd Webber back-catalogue rolled up together. Gee, Officer Krupke!, banned by the BBC for its mentions of drug use (ìDear kindly judge, Your Honour, my parents treat me rough, with all their marijuana, they won't give me a puffî) and sexual ambiguity ("My sister wears a moustache, my brother wears a dress, goodness gracious that's why I'm a mess"), is blazing satire, vintage 1957.
I Feel Pretty, although sung by Nixon, allows Wood to be funny for a stretch rather than a saintly killjoy. If you wonder why the Academy handed out Oscars to Chakiris (a one-way ticket to Palookaville) and Moreno (the most explosive performer in the film), look no further than the standout song, America.
On stage, this was a smaller number, with Anita's friends arguing with a conservative Puerto Rican girl. In the film, by matching the integrationist girls ("Free to be anything you choose") with the resentful boys ("Free to wait tables and shine shoes"), the conflict is more even, and we get a blazing musical battle at once celebration and indictment. A classic musical scene in a classic musical film.
The Warriors as pre-imagined by Gene Kelly, this really is the musical for people who dont like musicals.


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Amphetamine-induced psychosis - a separate diagnostic entity or primary psychosis triggered in the vulnerable?
Use of amphetamine and methamphetamine is widespread in the general population and common among patients with psychiatric disorders. Amphetamines may induce symptoms of psychosis very similar to those of acute schizophrenia spectrum psychosis. This has been an argument for using amphetamine-induced psychosis as a model for primary psychotic disorders. To distinguish the two types of psychosis on the basis of acute symptoms is difficult. However, acute psychosis induced by amphetamines seems to have a faster recovery and appears to resolve more completely compared to schizophrenic psychosis. The increased vulnerability for acute amphetamine induced psychosis seen among those with schizophrenia, schizotypal personality and, to a certain degree other psychiatric disorders, is also shared by non-psychiatric individuals who previously have experienced amphetamine-induced psychosis. Schizophrenia spectrum disorder and amphetamine-induced psychosis are further linked together by the finding of several susceptibility genes common to both conditions. These genes probably lower the threshold for becoming psychotic and increase the risk for a poorer clinical course of the disease.
The complex relationship between amphetamine use and psychosis has received much attention but is still not adequately explored. Our paper reviews the literature in this field and proposes a stress-vulnerability model for understanding the relationship between amphetamine use and psychosis.
Amphetamine and methamphetamine (hereafter amphetamines) can prolong wakefulness, increase focus and feelings of energy as well as decrease fatigue. They can produce euphoria, induce anorexia, and be used to treat narcolepsy and attention deficit/hyperactivity disorder (ADHD). Adverse effects include anxiety, aggression, paranoia, hyperactivity, reduced appetite, tachycardia, increased breathing rate, dilated pupils, increased blood pressure, headache, insomnia, palpitations, arrhythmia and others
Amphetamines inhibit dopamine reuptake by interacting with the dopamine transporter (DAT), thereby increasing the concentration of dopamine in the synaptic cleft
Amphetamines are highly addictive drugs. Both amphetamine and methamphetamine act directly on the mesolimbic dopaminergic "reward system"
Abuse of amphetamines is widespread in the general population
There is overwhelming evidence that patients with psychotic disorders have an increased vulnerability to compulsive use of drugs of abuse
The association between amphetamine use and psychosis has received much attention
Prevalence and clinical presentation
Observations strongly suggest a relationship between the intake of amphetamines and the development of acute psychosis. First, early studies demonstrated that amphetamines could trigger acute psychosis in healthy subjects. In these studies, amphetamine was given in consecutively higher doses until psychosis was precipitated, often after 100–300 mg of amphetamine
Amphetamine has a terminal elimination half life (T½) of 12–15 hours
The symptoms of psychosis induced by amphetamines are very similar to those of acute schizophrenia spectrum psychosis and include: lack of concentration, delusions of persecution, increased motor activity, disorganization of thoughts, lack of insight, anxiety, suspicion and auditory hallucinations
In contrast to schizophrenic psychosis, acute psychosis induced by amphetamines seems to have a faster recovery
Risk factors and acute vs. chronic psychosis
In animal models, there is sensitization to the rewarding effects of amphetamines (e.g.
In addition to the increased risk of psychosis following the use of amphetamines in people who have experienced amphetamine-induced psychosis previously, patients with schizophrenia
Several susceptibility genes have been found in common for amphetamine-induced psychosis and schizophrenia
The precipitation of psychosis by amphetamines in healthy subjects can be blocked by anti-psychotics
To further complicate the situation, it seems that up to 25% of those initially diagnosed with drug induced psychosis after some years develope a primary psychotic disorder
Also for other substances of abuse with a tendency to cause psychosis there have been similar discussions. It has long been recognized that the use of cannabis in early adolescence increases the risk of later development of psychosis and schizophrenia
A model for the relationship between psychosis induced by amphetamines and primary psychotic disorder
The similarities between acute schizophrenic psychosis and psychosis following the use of amphetamines are so pronounced that the latter has been suggested as a model for schizophrenia
In this context, we hypothesize that the relationship between amphetamine-induced psychosis and primary psychosis can be viewed within the framework of a traditional vulnerability stress paradigm (Figure
Figure 1
The relationship between amphetamine use and the development of psychosis can be understood with a traditional stress/vulnerability paradigm
The relationship between amphetamine use and the development of psychosis can be understood with a traditional stress/vulnerability paradigm. Some users of amphetamine will not develop psychosis even using high amounts, while others will develop psychosis with little or no exposure.
Taking such a view may have some important clinical implications. Patients diagnosed with drug induced psychosis following intake of amphetamines should be monitored more closely, in particular for signs of a chronic development. Any further use of amphetamines should be strongly discouraged, since it would constitute an acute stressor that could precipitate psychosis and increase the individual's vulnerability to developing a more chronic psychotic disorder. This model also provides a rationale for future studies of preventive anti-psychotic treatment, including psycho-social, psycho-educational and possibly also pharmacological interventions to decrease vulnerability, in the same way as is recommended for individuals with a primary psychotic disorder.
Competing interests
None of the authors have any conflicts of interest to declare.
Authors' contributions
All the authors have contributed substantially to the idea, structure and content of the paper. All authors have discussed all concepts and formulations in the final manuscript and have approved the submitted versions. JGB has, as first author, written the first draft of all the sections, but these have been altered and reformulated by all the authors in several collaborating rounds.
Methamphetamine abuse: a perfect storm of complications
Amphetamine: effects on catecholamine systems and behavior
The psychology and neurobiology of addiction: an incentive-sensitization view
Hospital separations for cannabis- and methamphetamine-related psychotic episodes in Australia
The epidemiology of methamphetamine use and harm in Australia
Prevalence of nonmedical methamphetamine use in the United States
The prevalence of methamphetamine and amphetamine abuse in North America: a review of the indicators, 1992–2007
The rise of methamphetamine in Southeast and East Asia
An emerging problem: methamphetamine abuse among treatment seeking youth
Substance abuse in hospitalized psychiatric patients
Drugs of abuse among acute psychiatric and medical admissions: laboratory based identification of prevalence and drug influence
Substance abuse in schizophrenia: a review of the literature and a study of correlates in Sweden
Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study
The level of illicit drug use is related to symptoms and premorbid functioning in severe mental illness
Differences in prevalence and patterns of substance use in schizophrenia and bipolar disorder
A neurobiological basis for substance abuse comorbidity in schizophrenia
Ventral and dorsal striatal dopamine efflux and behavior in rats with simple vs. co-morbid histories of cocaine sensitization and neonatal ventral hippocampal lesions
Drug-induced psychosis: how to avoid star gazing in schizophrenia research by looking at more obvious sources of light
The phenomenology of experimentally induced amphetamine psychosis–preliminary observations
The experimental reproduction of amphetamine psychosis
Paranoid episodes induced by drugs
Amphetamine psychosis and psychotic symptoms
Chlorpromazine vs. amphetamine
Acute psychosis associated with therapeutic use of dextroamphetamine
Methylphenidate hallucinosis
Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder
Psychosis associated with prescribed dexamphetamine use
Adderall-induced psychosis in an adolescent
Paranoid psychosis in narcolepsy and possible dangers of benzedrine treatment
Clinical course and outcomes of methamphetamine-dependent adults with psychosis
Methamphetamine-Associated Psychosis
Methamphetamine and paranoia: the methamphetamine experience questionnaire
The prevalence of psychotic symptoms among methamphetamine users
Psychiatric and substance dependence comorbidities, sexually transmitted diseases, and risk behaviors among methamphetamine-dependent gay and bisexual men seeking outpatient drug abuse treatment
Methamphetamine use, dependence and treatment access in rural and regional North Coast of New South Wales, Australia
Comorbid psychiatric disorders, sex, and methamphetamine use in adolescents: a case–control study
Relationship between gender and psychotic symptoms in cocaine-dependent and methamphetamine-dependent participants
Methamphetamine in Japan: the consequences of methamphetamine abuse as a function of route of administration
Methamphetamine use in rural Midwesterners
A comparison of symptoms and drug use between patients with methamphetamine associated psychoses and patients diagnosed with schizophrenia in two acute psychiatric wards
Amphetamine availability and admissions for psychosis in New South Wales, 2001–2009
Clinical features of sensitization to methamphetamine observed in patients with methamphetamine dependence and psychosis
A retrospective review of trends and clinical characteristics of methamphetamine-related acute psychiatric admissions in a South African context
Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and non-conventional matrices
An escalating dose "binge" model of amphetamine psychosis: behavioral and neurochemical characteristics
Impulsivity and methamphetamine use
Psychosocial and behavioral correlates of depressed mood among female methamphetamine users
Adverse effects of stimulant drugs in a community sample of drug users
Symptoms and drug use among (meth)amphetamine positive patients admitted to the acute psychiatric ward
Stimulant psychosis: symptom profile and acute clinical course
A rating scale for evaluation of the clinical course and symptomatology in amphetamine psychosis
Psychotic symptoms in methamphetamine psychotic in-patients
Studies of amphetamine or methamphetamine psychosis in Japan: relation of methamphetamine psychosis to schizophrenia
Comparisons of methamphetamine psychotic and schizophrenic symptoms: a differential item functioning analysis
Comparison of amphetamine psychosis and schizophrenia
Methamphetamine-Associated Psychosis: A model for Biomarker Discovery in Schizofrenia
Amphetamine Psychosis: I. Description of the Individuals and Process
Book Review of "Amphetamine Psychosis" by P. H. Connell
Six months follow-up of patients with methamphetamine psychosis
Remission of persistent methamphetamine-induced psychosis after electroconvulsive therapy: presentation of a case and review of the literature
Susceptibility to subsequent episodes in spontaneous recurrence of methamphetamine psychosis
Longitudinal clinical course following pharmacological treatment of methamphetamine psychosis which persists after long-term abstinence
Long-term outcomes in methamphetamine psychosis patients after first hospitalisation
Factors for susceptibility to episode recurrence in spontaneous recurrence of methamphetamine psychosis
Susceptibility to episode recurrence in spontaneous recurrence of methamphetamine psychosis
The role of noradrenergic and dopaminergic hyperactivity in the development of spontaneous recurrence of methamphetamine psychosis and susceptibility to episode recurrence
Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis
Human response to repeated low-dose d-amphetamine: evidence for behavioral enhancement and tolerance
Selective sensitization to the psychosis-inducing effects of cocaine: a possible marker for addiction relapse vulnerability?
Pre-morbid characteristics and co-morbidity of methamphetamine users with and without psychosis
Physical and mental health problems in amphetamine users from metropolitan Adelaide, Australia
Long-lasting hypersensitivity to methamphetamine following amygdaloid kindling in cats: the relationship between limbic epilepsy and the psychotic state
Acute exacerbation of paranoid psychotic state after long-term abstinence in patients with previous methamphetamine psychosis
Neurotoxic effects of amphetamine plus L-DOPA
Neuromechanism of developing methamphetamine psychosis: a neuroimaging study
Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress
Increased baseline occupancy of D2 receptors by dopamine in schizophrenia
All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2 Receptors
Provocative tests with psychostimulant drugs in schizophrenia
Subtypes of drug abuse with psychosis. Demographic characteristics, clinical features, and family history
Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis
The risk of psychotic symptoms associated with recreational methamphetamine use
Findings of preserved implicit attention in methamphetamine dependent subjects
Precipitating factors in spontaneous recurrence of methamphetamine psychosis
Amphetamine poisoning. Effectiveness of chlorpromazine
Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials
Treatment for amphetamine psychosis
A 4-week, double-blind comparison of olanzapine with haloperidol in the treatment of amphetamine psychosis
The effects of clozapine on alcohol and drug use disorders among patients with schizophrenia
Effectiveness of combining atypical antipsychotics and psychosocial rehabilitation in a community mental health center setting
Six-month outcomes for patients who switched to olanzapine treatment
Efficacy of lorazepam and haloperidol for rapid tranquilization in a psychiatric emergency room setting
The expert consensus guideline series. Treatment of behavioral emergencies 2005
Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA
Differences between early-phase primary psychotic disorders with concurrent substance use and substance-induced psychoses
Substance-induced psychosis: a diagnostic conundrum
Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review
Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study
Cannabis and psychosis/schizophrenia: human studies
Testing hypotheses about the relationship between cannabis use and psychosis
Cannabinoids and psychosis
Methamphetamine use and schizophrenia: a population-based cohort study in California
Amphetamine psychosis: a model for studying the onset and course of psychosis
Pre-publication history
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Port Royal Homes: H.8584 - One of the most significant beachfront residences ever created for the Gulf of Mexico. This magnificent Island-Colonial mansion is brilliantly orchestrated to capture stunningly beautiful views that sweep out across the Gulf. Crowning 4.08 acres of direct beachfront with 277 ft. of sandy shore this exquisite 15,995 sq. ft. home has no equal. Designed by Smith Architectural Group and constructed by Newbury North Associates, the construction quality and materials used are unsurpassed. This five bedroom, six bath villa features exquisite details such as coral stone from the Dominican Republic, wide plank wood flooring, extensive Venetian plaster walls, wainscoting w/ raised paneling, elaborate ceiling details, gourmet styled kitchen and more. The Great Room has five sets of French doors that open on to a 93 ft. terrace. Other features include a morning room loggia and Gulf loggia with retractable motorized glass walls, 66 ft. pool with spa and sun shelf and a 7-car collector's garage. Luxuriant gardens and botanical-like grounds create a rarefied splendor seldom found. Eligible for associate Port Royal Club membership, three doors from club. FLEXIBLE TERMS CONSIDERED.
Port Royal Homes: The original owners of this estate chose a Lowcountry style home architecture, one of the most distinctive elements of South Carolina and Georgia developed in the late 1700's. It is still considered today to be the most efficient design for hot subtropical climates and coastal areas. These designs are typically elevated with raised first floors, inviting porches to enjoy the outdoors in the shade, underfloor spaces with lattice for storage/ parking, hipped roofs, columns/pillars, widow's walks, large windows and doors that allow a cooling breeze to flow through. The finest team of craftsmen were assembled to create this breathtaking vision whose true success lies in its welcoming Presidents, huge charity events, casual family gatherings and private contemplation, all with the same grace and charm. An enchanting setting through ornate gates opens to stands of palm trees, verdant lawns and privacy hedges surrounding the main home, multiple guest facilities, pool, pool house, various garages and service buildings, and even your own 'secret garden'.
Port Royal Homes: H.8607 - La Capanna represents one of the most significant beachfront residences ever created in Naples. Old world Italian renaissance era ambiance takes inspiration from an ideal beachfront location giving it the feel of a Mediterranean seaside resort. Beyond a gated entry, park-like grounds part to reveal a palatial 18,172 sq. ft. estate home that is unsurpassed. Includes a home theater, beach side game room, fitness center, pool side cabana with pergola covered spa, his and her studies, Guest House, 5-bay collectors garage and finishes that redefine luxury and quality. Stunning two story rotunda welcomes guests and offers immediate Gulf views. Relax or entertain in this handsome lounge, featuring a full Mahogany bar with emerald marble bar top, marble floors and a burnished faux finished coffered ceiling. Additional features include a 500 bottle wine room, state of the art electronics, whole house Crestron automation, interactive fountain with LED lighting and much more. Relax in the Zero Edge pool/reflection pool and poolside cabana with full kitchen that is ideal for entertaining. La Capanna is a masterful blend of design, craftsmanship & artistry by A. Vernon Allen Builders.
Port Royal Homes: This superb home with revered architectural antecedents is positioned along one of Port Royal's most magnificent waterways. Built with attention to detail and following demanding construction protocols, the "genius loci" is a graceful union of comfort and function. It is recognized as one of the very finest homes ever built in Naples, Florida.
Port Royal Homes: A beachfront estate in Port Royal at 4228 Gordon Drive is uniquely sited on a homesite with over 200 feet of wide sandy beach and spectacular sunsets over the Gulf of Mexico. This well-constructed property offers 9,000 square feet under air and presents an opportunity for refurbishing to suit your individual tastes or to build new. Rarely is a property of this size with this much beach front available in Naples. Residents may join the Port Royal Club, one of the finest beach clubs in the country. From world-class dining to a terrific tennis and fitness center, top-notch service and an active social calendar, it adds to the allure of one of the most prestigious waterfront communities in the United States. This idyllic location is just minutes from the Third Street South shopping district with charming historic architecture, lushly landscaped promenades, and the latest in couture design, fine art and creative fare from around the world.
Port Royal Homes: A truly magnificent estate commanding incomparable water views, this uniquely situated masterpiece rests on approximately 340 feet of water frontage (as per plat). Architecturally significant in its own right, the residence is striking in its attention to detail. Entering the archway overhanging the entrance gates to the massive stone courtyard beyond, there is the feeling of integrity and dimension in the classical vernacular. The courtyard permits entrance to the two story gate house, which accommodates three guest rooms, a game room, and a garage, allowing total privacy for family and visitors. A spectacularly appointed eat-in kitchen with the latest appliances serves both the formal dining area with its detailed appointments and the massive informal dining area which overlooks the entrance to the southern waterways. A warm library leading to the club room with well designed theater and wine cellar constitute the southern first floor of the home. Upstairs, there are five bedrooms and a truly unique master bedroom suite. The master suite also boasts large walk-in closets. The master bedroom has arguably the best bay views in all of Naples.
Port Royal Homes: H.10490 - This exquisite Southern-Colonial estate sits on an iconic Gordon Drive site comprising 2.53 acres, approximately 150 feet of wide sandy beachfront and offers captivating Gulf of Mexico vistas. The main house includes 3 bedrooms + study and sprawls across 6,209 Sq.ft. of living area with timeless style and casual elegance. From the minute you enter this estate through the magnificent central hallway you will be entranced by the Gulf views and beautiful floating wood staircase. Features include wood and marble flooring, fan windows, intricately carved marble and stone gas fireplaces, beautiful custom millwork and much more. The expansive master suite boasts a marble and stone gas fireplace, large sitting area, 30' x 36' balcony, large Walk-in-Closet and beautiful Calcutta marble floored master bath. One can sit back and enjoy the sparkling Gulf of Mexico waters from the 94-foot terrace or balcony upstairs. Property includes two guest houses near the front of the estate site. Eligible for membership to the exclusive Port Royal Club.
Port Royal Homes: This home is boasting the most idyllic setting in all of Port Royal with unobstructed, wide-water, views and preferred southern exposure. With classic Palm Beach infused architecture by Jeffrey A. Harrell Architects, the quality craftsmanship of BCB Homes, this stunning estate is destined to raise the bar on Port Royal excellence. Complemented by a separate guest house that seems to ascend from the resort-style pool, this unique property offers attributes and vistas that others simply cannot provide.
Port Royal Homes: The one and only 3450 Rum Row is your private escape to Hidden Bay in Port Royal. With over 8,200 square feet under air, this estate by renowned developer Michael Mullen and award-winning architect Jon Kukk is paradise inside and out. This masterpiece is a place where sophistication, style and craftsmanship meet for the ultimate in waterfront living. A truly magnificent, classically designed home with six bedrooms, it is perfectly situated on a most desirable oversized lot and one-half in Port Royal. Enjoy 158 feet of waterfront in Port Royal with access to the Gulf of Mexico. This home has unbelievable southwest exposure with long views down Man-of-War Cove. The main level of the home emphasizes outdoor access with disappearing doors in the living room and family room that create a truly seamless indoor-outdoor space. The covered outdoor living area allows you to enjoy sunsets amidst a negative edge pool with spa and stone fireplace. The gourmet kitchen will have the finest cabinetry and appliances, a private dining room with French doors out to a beautiful courtyard, butler's pantry and a well-appointed library with views of Hidden Bay.
Port Royal Homes: Best value in Port Royal...Incomparable Port Royal Estate home with wide water views of Buccaneers Bay. Walls of glass disappear offering seamless indoor and outdoor living areas. This estate comes fully furnished, and designed by Godfrey Design Consultants. Bronzed sculptures of fire and water by a world-renown artist flow into the gorgeous infinity pool. Murano glass and commissioned artwork specifically designed for this home. These are just a few of the fine points that compliment this stunning property. Spacious outdoor kitchen and lanai with keystone fireplace and outdoor bar. Master bedroom with his and her baths, stunning hand carved marble tub, and private dressing rooms. There are five additional impressive guest suites. Gated entry with 5 car garage. The magnificent gardens and landscaping that surround this property are beyond compare.
Port Royal Homes: This two-story, waterfront grand estate showcases water views with floor-to-ceiling windows, bay windows in the master suite and sliding glass doors that open to outdoor gathering areas. Overlooking Cutlass Cove toward the southernmost point of scenic Gordon Drive in Port Royal, two reflecting pools with mosaic-tiled spillovers flank each side of the stairway to the linear pool and spa. Fully furnished by Romanza Interior Design, the residence offers a study, formal dining room, elevator and floating staircase. A loft, lounge, morning kitchen and two guest suites are located on the second floor. A V.I.P. suite is designed as a second master suite, with covered terrace overlooking the pool, and a guest apartment above the two-car garage offers a private retreat. The home offers a private boat dock with access to the Gulf of Mexico through nearby Gordon Pass, and includes membership eligibility in the exclusive Port Royal Club and Cutlass Cove Beach Club
Port Royal Homes: Absolutely stunning Port Royal residence located on one and one half Port Royal lots. Immaculately maintained home with among the very best long water views in Port Royal. Unimpeded views from the gourmet kitchen and expansive family room to the exciting outside pool and multiple entertainment areas. Award winning theater. Port Royal Club membership eligibility.
Port Royal Homes: A rare opportunity to acquire an exquisite and expansive custom estate site that spans two-and-one-third house lots, totaling approximately 1.25 acres. This spectacular building site is the crown jewel of land parcels on the deepwater yachting basin of Morgan's Cove and boasts more than 230 feet of waterfront with no bridges to the Gulf. Build your dream home and enjoy Port Royal Club membership eligibility. The existing house is offered as-is with right to inspect. Interested parties may not walk the grounds without the presence of the listing agent. Contact the listing agent for a copy of the survey and the site plan.
Port Royal Homes: Beachfront retreat with disappearing glass walls set the stage for an incomparable panoramic view of the Gulf of Mexico. Architecturally designed exterior and interior with hand-painted, deep crown moldings, volume coffered ceilings highlighted with interior lighting and architectural stone trimmed fireplace add elegance to this 3 bedroom, plus den, 3.5 baths. A plush home theater and a family room media center add opportunities for family entertainment. The infinity edge pool and oversized spa overlooks the beach and gulf with a lanai summer kitchen. Separate 2 Bedroom / 2 Bath Guest Quarters. Eligible for Associate Port Royal Club Membership.
Port Royal Homes: Why Build? Save 3 years. Beautiful custom home completed in 2016 and constructed by The Williams Group. This timeless home designed by Stofft Cooney boasts one of the longest views of Morgan's Cove and is just a short walk to the Port Royal Club and the sugar sand beaches of the Gulf of Mexico. No detail was overlooked. The entry foyer with it's grand staircase, substantial millwork and 24 ft. nickel groove ceiling leads you to the large Great Room with custom built-in's. The approximately 2500 sq ft. of outdoor living space includes infinity spa, large pool, outdoor living room with fireplace and kitchen. The stunning white on white chefs kitchen offers state of the art appliances, (including a 60 inch Viking range) a wall of windows and white honed marble countertops. Outside of the kitchen is a butler pantry and bar which is adjacent to an elegant dining room perfect for entertaining, including a custom wine room which will accommodate 1000 bottles of wine. There are 11 ft. ceilings throughout much of the home. Custom doors lead to both upper and lower expansive living spaces. Offered decorator furnished. This is Port Royal living at it's finest.
Port Royal Homes: Elegance abounds in this luxurious, recently remodeled 10,000-square-foot, European-style home situated on sparkling Naples Bay in the heart of Port Royal. Beyond the gated entry are manicured gardens adorned with fountains, softly illuminated at twilight. Inside, the striking, two-story foyer features dual grand staircases leading to the second floor. Freshly remodeled and updated with fabulous finishes, the home features five bedrooms, six full bathrooms and four half-baths with master suite and privacy garden conveniently located on the first floor. The gourmet kitchen has top-of-the-line appliances, an adjoining wine room and a morning room with bay views. Other amenities include a theater, formal library, exercise room, and two elevators. A fully equipped, 1,100-square-foot attached casita is ideal for guests or staff. Overlooking the Bay is the spacious lanai with a full summer kitchen and fireplace. Beyond, the infinity-edge swimming pool with spa is surrounded by ample lounge areas and offers sweeping Bay views. A gorgeous second-floor lanai also affords views of the dock, boat lift and 180-degree water views.
Port Royal Homes: Built by London Bay Homes, this two-story, waterfront grand estate home is designed with a second-floor master suite and private balcony to maximize water views overlooking Cutlass Cove, the southernmost point of scenic Gordon Drive in Port Royal. Fully furnished by Romanza Interior Design, the home features a study, wine cellar, elevator and a second-floor loft with morning kitchen. The model's open floor plan features a spacious great room and adjoining kitchen and dining area. The great room's wall of stacking sliding glass doors open to an elevated outdoor living area equipped with a summer kitchen, overlooking the linear pool and spa. The home offers a private boat dock with access to the Gulf of Mexico through nearby Gordon Pass, and includes membership eligibility in the exclusive Port Royal Club and Cutlass Cove Beach Club. Fall 2017 completion.
Port Royal Homes: H.11469 This grand estate home with wide water vistas across Hidden Bay, features a floating dock to accommodate vessels up to 70' and direct access to the Gulf of Mexico (no bridges). The lushly landscaped and manicured front yard with inviting driveway help set the stage for what awaits inside the home. The floor plan is designed to meet every need of the most discerning buyer. Your eyes are drawn immediately through the floor-to-ceiling sliding glass walls to the sparkling blue infinity-edge pool, spa and fountains overlooking Hidden Bay. The large living room and adjoining family room are immediately adjacent to two oversized covered lanais, each tastefully furnished and inviting as magical places in which to relax. The dining room, gourmet kitchen, morning room, master suite featuring his and her bathrooms, study, laundry room and 2nd bedroom complete the first floor. The second floor features an oversized junior suite, 2 bedrooms ensuite plus a huge game room with glass slider access to a huge covered balcony and an additional bonus room to meet your personal desires. Elevator and 3-car garage. Estimated delivery mid-late 2019. Immediate Port Royal Club Membership available.
Port Royal Homes: JUST COMPLETED. The Pirate's Walk. From the artisans that brought you 3510 Fort Charles Drive comes a phenomenal new Bermudian style retreat in Port Royal. Meticulously designed by Jon Kukk, this enchanting home sits on an oversized lot with ideal southern exposure for all day sun and fun. Quick access to Naples Bay and the Gulf via Harbour Head will make this attractive for the active sportsman or casual boater. The open and inviting floor plan will flow seamlessly to the outdoor living area and the over-the-top resort- style pool and spa with semi circle seating with fire pit. 5 full bedrooms, 6 full baths and 1 half bath have been expertly designed for maximum enjoyment. The master suite will boast beautiful space with natural light and completed by the custom oversized closets. The interiors such as the wide plank DuChateau wood floors, chef's style kitchen and upgrades throughout thoughtfully assembled by Lisa Kahn Design Group, one of Naples' finest designers. Christian Andrea has created an inviting serpentine entry and enchanting curb appeal thru the mix of landscapes and hardscapes. Immediate Port Royal Club eligibility for one of Naples' ultimate new luxury retreats.
Port Royal Homes: A gorgeous custom built, British West Indies influenced residence which looks southwest over Runaway Bay in the prestigious Port Royal community. Recently completed and featuring over 7,500 square feet of living space including six bedrooms and a first-floor study. Wide plank oak floors grace the first floor which is home to a serene master suite which includes a stunning, white ensuite bathroom with custom rainfall shower, his/hers closets, matte finish oversized soaking tub and more. The upstairs is accessible by elevator, leading to a media room with a wet bar, two guest suites and a VIP bedroom suite with an outdoor terrace overlooking the bay and sunset skies.
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Lol, i really feel bad for the guy
Most Helpful Girl
Next was a lame MTV show, don't take it seriously. There probably are people who are that shallow, but definitely not all.10|10|1
Most Helpful Guy
Damn I'm 5'4 but that shit was funny (bet I wouldn't be laughing if it happened to me), I haven't had a girlfriend so it's hardly a great trait, I know that people don't take me very seriously a lot of the time and probably less masculine so it's not that good but I don't think it's that bad she is just one case.10|10|0
You are still 17. I was 5'11 if i recall correctly at your age, now im 6'2. Beside, dont ever think you are "less masculine" because of your height, many girls dont really care about things like that
Well my dad is 5'6 so I don't think there's much to go, I don't care if people think I look like a child or whatever I've heard before tbh I'm just focused on the gym now, looking less like a skinny DYEL everyday.
Yes! Thats the spirit