text: [ QUOTE ] Im gettin to like all this carbon, do like the roof on that color,You can get a carbon shell now to fit on your M3 roof, at first I thought no, leave it to the CSL, but I dont know now, its growing on me , carbon is well in at the mo and likely to get real popular in the future!! The c/f roof ( shell) that you stick on somehow is around £800 ish, expensive but I bet someones done it already and like the CSL could look real cool!! [/ QUOTE ] I thought the CF roof was exclusively manufactured by BMW Landshut Plant and thought is would cost much, much more than 800 quid ? Maybe I'm wrong.

subset: commoncrawl


text: Zenergy, Inc. ("Zenergy") and funds managed by affiliates of Apollo Global Management, LLC (NYSE:APO) (together with its consolidated subsidiaries, "Apollo") have formed a partnership to invest in the acquisition and development of upstream and midstream oil and gas properties. The partnership was formed effective May 1, 2014 with total committed capital of $700 million from funds managed by affiliates of Apollo and $55 million from Zenergy, its affiliates and management team. The partnership, Zenergy, LLC, will focus on assets in the Mid-Continent, Texas and Arkansas-Louisiana-Texas regions. Zenergy Chief Executive Officer and Co-Founder Bob Zinke said, "I am extremely pleased to partner with Apollo given its stellar track record and reputation as one of the world's leading alternative investment managers. With its depth of operating experience and strength as a capital provider, we believe Apollo is perfectly positioned to help us create a best-in-class entity to tap into the enormous opportunities across the world-class fields in our focus areas." Sam Oh, Apollo Private Equity Senior Partner said, "We are extremely delighted to be partnering with such a premier oil and gas firm whose long and proven track record fits with our strategic investment objectives in the lower 48 states." Jefferies, Inc. served as financial advisor to Zenergy. About Zenergy Zenergy, Inc. (f/k/a) Zinke & Trumbo, Inc., founded in 1980 by Chief Executive Officer Bob Zinke and Senior Vice President Exploration David Trumbo, is headquartered in Tulsa, Oklahoma and maintains a regional office in Houston, Texas. The Company, which employs 60 people, specializes in all phases of the upstream and midstream oil and gas business. Zenergy organically and successfully assembled, operated and sold three businesses in the upstream and midstream spaces of the Bakken/Three Forks plays in the Williston Basin, North Dakota. In these ventures Zenergy assembled over 300,000 net acres of oil and gas leasehold, drilled and completed over 250 horizontal wells and successfully installed and operated over 450 miles of oil, gas and produced water gathering systems.


text:
The Goodness of Sabbath Rest
God's gift of Sabbath allows us to rest in his sufficiency.
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I. Commemorating creation and salvation
II. More than just a rule
III. Resting in God's strength and sufficiency
IV. Out of rest, we work
V. Out of rest come relationships
Charles Price is the Senior Pastor of The Peoples Church in Toronto, Ontario, Canada and the founder of Living Truth, an international teaching and preaching ministry.
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36 Desoto Airflow. No title. Not running. No radiator/grill etc. Rusty floors and rockers. $2500. DANS OLD CARS
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Today I introduce the Georgian Southern belle, Vett, from Real College Student of Atlanta! It's almost like trading places with her this week, she's blogging here at the Darling Prepster (which is only kinda like visiting Ohio...right? ok, it's a stretch...) and I'm in Georgia for the week! Anyways, Vett blogs about, wait for it...Atlanta! Read her blog and you'll learn all the ins and outs of living the Atlanta lifestyle. From the food and restaurants to whats going on at her school, and everything in between! Definitely check out her blog!
Hey y'all! My name is Vett and I'm a college senior at Georgia Tech in Atlanta, also known as the Real College Student of Atlanta. I love sweet tea, fashion, monograms, sparkly items, writing, and all things southern!
I've put together one of my favorite looks in an OOTD called "Southern Comfort." I basically live in this type of outfit: a patterned top/dress, leggings, cowgirl boots, and a blazer. I'll occasionally include a scarf or other accessory, but people love this look that's so easy to pull off!
I love how this outfit works for just about any type of weather because you can add or remove layers, and it looks casual yet classy!
What's your go-to look?
Ah, cowboy boots, I should add those to my to-get list! Such a cute outfit, Vett! Thanks so much!
With Love,


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About the Book
Simple snapshots of beautiful Columbia County in New York State, seldom composed, most often shot from a car window being too lazy to get out but still wanting to keep an image permanently.
Features & Details
- Category Travel
Small Square, 7×7 in, 18×18 cm
36 Pages
- Publish Date May 20, 2012
- Tags Columbia County, Columbia County New York, Dan's Diner, Hudson NY, Hudson Valley, Columbia County photography, Olana, Austerlitz, Berkshires, Steepletop
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About the Creator
An apparel designer of primarily swimwear and intimates Irene Aizstrauts is branching out into other markets such as bridal and special occasion. She's an atlas reading geek who can't resist a road trip; a Lake Ontario sunset watcher, prankster and an equestrienne who loves to jump judge the exhilarating cross country phase at horse trials in Upstate New York.
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Question: How do you find the median for a data set a
How do you find the median for a data set:
a. With an odd number of values?
b. With an even number of values?
View Solution:
a. With an odd number of values?
b. With an even number of values?
View Solution:
Answer to relevant QuestionsConsider the quality of cars, as measured by the number of cars requiring extra work after assembly, in each day's production for 15 days: 30, 34, 9, 14, 28, 9, 23, 0, 5, 23, 25, 7, 0, 3, 24 a. Find the average number of ...Consider the percent change in housing values over a five-year period for regions of the United States, as shown in Table 4.3.5. a. Find the mean and median percent change in housing values. b. Find the five-number summary ...Consider the following list of your products' share of 20 major metropolitan areas: a. Find the average and the median. b. Draw a cumulative distribution function for this data set. c. Find the 80th percentile. Consider the costs charged for treatment of heart failure and shock by hospitals in the Puget Sound area, using the data from Table 3.9.6 of Chapter 3. a. Summarize the costs. b. Draw a box plot. c. Draw a cumulative ...For the annual salary levels: a. Find the average. b. Find the median. c. Construct a histogram, and give an approximate value for the mode. d. Compare these three summary measures. What do they tell you about typical ...
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This property is no longer available.Search for Available Property.
8.37 acres in Frederick County, Maryland
Welcome to scenic Johnson's Hilltop. Some of the best views looking down Middletown Valley. ONE ALREADY SOLD. Some wooded/ some open for big views. 6 bedroom perk. Long asphalt driveway already built. Electrical conduit already run. Ready building permit. Shared Driveway and Covenants in place. AGENTS THIS IS NOT A DRIVE BY PROPERTY. Call for COMBO TO GATE.LA. WILL GLADLY MEET YOU TO PRE-SHOW.
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NOTE: The information contained herein is provided as general information only and has been obtained from sources deemed reliable. It is provided without any guaranty, warranty or representation, expressed or implied, made by Lands of America, or any related entity, as to the accuracy or completeness of the information. The information is presented subject to errors, omissions, change of price or conditions, prior sale or withdrawal without notice. Prospective purchasers should make their own investigations, projections and conclusions concerning the information.


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Helena 'Levity' The New Festival Anthem For Summer 2014
Get your hands up for Australian DJ/producer Helena's 'Levity', brand new festival anthem. Levity is a new track collaboration of Helena with house music vocalist Shawnee Taylor that gives 'Levity'the next festival anthem with adrenaline rushing festive synth & beautiful vocals by Shawnee that get you charged up.
Helena has tackling the electronic dance floors at Ultra Music Festivals, Stereosonic and Future Music Festival and as well as performing at world's hottest clubs like Pacha & Marquee LA. Check out the exclusive premiere and preview of HELENA's latest track 'Levity'.
"I'm so excited to preview my forthcoming track – Levity! Featuring the vocal talents of the amazing Shawnee Taylor. Classic house meets 2014 – A perfect soundtrack to rock your summer! I hope you all love this one as much as I do!", said Helena. Levity is released on Ultra Music and out on 28th March.
Facebook: www.facebook.com/DJHELENA


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Brown irregular cross pendant with three Swarovski hand-painted.
The ceramic cross pendant is hand-molded and fired.
After firing, the pendant is colored and decorated then fired again at a temperature of 1000°C.
This process makes the product resistant over time.
Precious pendant cross with Swarovski that gives brightness to the cross.
- Model: PT003008
- Shipping Weight: 0.05Kg
- Materials: Swarovski cristal, ceramic, rubber string, metal
- Origin: Hungary
- MEASURESUnits:
- Cross height: 3.5 cm
- Cross width: 3.2 cm
- MEASURESUnits:
- Cross height: 1.38 in
- Cross width: 1.26 in


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KaiserShoutmon is a Fan:Royal Digivolution of Shoutmon. He take a similar appearance of EmperorGreymon but with a lot of changes, his Headphones turn into horns, his hands become Knight-like, his feet become more Susanoomon-like, his body looks more Knight-like, his V is now enlarged, he has a cape with the Xros Heart logo on it, his sword is similar to Imperialdramon Paladin Mode's sword and his face is similar to EmerorGreymon's. He is also known to be a Royal Knight and the ruler of the Digital World, his companions, Fan:SupremeGreymon and Alphamon come along side him through out. He is ememies with the Seven Great Demon Lords and Baguramon and also Fan:CreepyPastamon. He vows to all Digimon in the Digital World about him, he says, "If i die in the hands of evil, my sword and courage will go to you, and all the ones you love."
Level: Mega Type: Data Family: Dragon's Roar, Virus Busters Value: Holy Knight Attacks:
- Kaiser Sword: Holds his sword in the air, waits for it to have full charge and then slashes it at full speed.
- Royal Rock Soul: His body glows in flames and unleashes a giant fire ball from his hands.
- Xros Sword: Holds his sword in the air, then the sword glows red with a dark red X surrounding it, and then unleashes it.


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Collado de Fadas rankings
Difficulty ranking world: 5817 (all)
Ranking Spain: 699 (all)
Difficulty score: 46.33 what?
Collado de Fadas ratings
(rate it)
The Collado de Fadas is situated in Aragon.
Starting from carr. Roda,
the Collado de Fadas ascent is 18.3 km long. Over this distance, you climb 560 heightmeters.
The average percentage thus is 3.1 %.
Look for other sides to climb the Collado de Fadas.
profile Collado de Fadas - click to open in new window
open big profile of the Collado de Fadas in a new window
Find climbs close to the Collado de Fadas: within 10 km - within 20 km - within 50 km
Find all climbs and cols in Aragon on a map.
No stories submitted yet. Did you climb this mountain?
Did you climb the Collado de Fadas? Please send your cycling story, description or comments. You can also send us video's or send us pictures on the Collado de Fadas.
© climbbybike™ All rights reserved 2005 -


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Redwood City, California – (The Hosting News) – April 13, 2007 – The Internet Systems Consortium and telecommunications company, Internet Service Provider firm, GPX Global Systems Inc., have installed a root name server in Cairo, Egypt.
The new project, fully supported by the Egyptian Ministry of Communications and Information Technology, was announced at the Cairo ICT 2007 Exhibition and Forum event. The new name server is expected to be installed and operational by the second quarter of 2007 at the GPX Middle East Internet eXchange (MEIX) located in the Cairo Heliopolis area, and will mirror the F-root, one of the 13 'Root Name Servers' around the world that control and organize accessibility to the Internet.
Paul Vixie, President of ISC commented. "ISC is pleased to be working with the Egyptian government and the GPX MEIX in bringing mission critical Internet services to the Middle East and North African community. The F-root server will enhance the experience of the growing Egyptian Internet community and will increase resilience and technical independence from external sources. This is also one more step in our goal to strengthen the foundation of the global network."
Virtually every Internet transaction, from sending an e-mail to finding a website, begins with a Domain Name System (DNS) query. A DNS query is the method computers use to translate a human readable name to a network address that a computer can find. This new ISC F-root server will store the information needed to answer the question of where several hundred top level domains, including .i.e., .net, .com; etc. can be found.
Minister Tarek Kamel, Egyptian Minister of Communications and Information Technology added, "We believe this partnership will further strengthen the quality and reliability of the Internet infrastructure in Egypt. We are delighted with the choice of Egypt, with its fast growing Internet market as a key location in the region, and welcome the initiative of ISC and GPX to install an F-root node in Cairo. We are sure this project will enhance the experience of Internet users not only in Egypt but throughout the region."
Nick Tanzi, Chairman of GPX offered, "Growth of Internet services in Egypt has been remarkable over the course of the last five years, promising to turn the country into the Internet hub for the Middle East and Africa. We are happy to support the ISC and the Egyptian Ministry in their efforts to further this growth and to provide a more stable environment for Internet usage in the region."
The Internet Systems Consortium, Inc. (ISC) is a non-profit public benefit corporation with a long history of developing and maintaining the production quality of Open Source software — BIND and DHCP. ISC has increased its focus to include enhancing the stability of the global DNS directly through reliable F-root name server operations and ongoing operation of a DNS crisis coordination center, ISC's OARC for DNS. ISC is also engaged with further protocol development efforts, particularly in the areas of DNS evolution and facilitating the transition to IPv6.
Incorporated in August 2002, GPX develops and operates a neutral Internet eXchange (IX) hosting facility in emerging, for growing commercial Internet markets along the undersea cable systems of FLAG, SEA-ME-WE3, and SEA-ME-WE4, as well as other regional cable systems. GPX IXs provides telecommunications companies (Telco's), Internet Service Providers (ISPs), e-businesses, and enterprise customers with a neutral data center environment to collocate mission critical communications and application platforms. In addition, the GPX IX provides a single physical location where customers can access a host of services from multiple providers.
To learn more, please visit: www.gpx.ie.


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Zoombies 2016 Watch Online Movie Free Full Movie HD Quality Download Free. Hollywood movies 2016.
Director: Glenn Miller
Writer: Scotty Mullen (screenplay)
Stars: Ione Butler, Andrew Asper, LaLa Nestor, Kim Nielsen
Runtime: 87 min
Rated: TV-14
Genre: Action, Horror, Sci-Fi
Released: 01 Mar 2016
Zoombies 2016 Watch Online Movie Free Full Movie HD Quality Download Free.
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Short Summary:
Zoombies 2016 is one of the Best Hollywood Movies of 2016. Release Date of this Film is 2 feb,2016. in the Country of USA. Zoombies Movie Director is Glenn Miller. In addition, Writer of this Action Picture is Scotty Mullen. Film Star cast are Ione Butler, Andrew Asper, LaLa Nestor, Kim Nielsen. Languages Of this Movie Are English and Hindi. Further watch more movies by Genres of this English Action,Adventure,Horror,Crime,Romance,Comdey,Animated,Biography
*** NOTE: If You Have Any Kind of Complaint About Video Quality or Broken Link. PLEASE Contact us. ***


text:
Hi all,
I saw that there have been some distressing conversations here about suicide. I've emailed Iwannabe ahero privately, but also wanted to check in here - I know how difficult it can be to see someone in pain and be stuck on the other side of a computer!
I'd like to give some general advice, which hopefully will help for the future.
Firstly, if you are seriously concerned about anyone online and think they are likely to hurt themselves, you should contact your local authorities (or, if you are under 18, talk to your parents or another responsible adult).
You may also want to suggest that the person calls the National Suicide Prevention Helpline on 1-800-273-TALK (8255). There's more about this phone line at http://www.suicidepreventionlifeline.org/GetHelp/Default.aspx . If they aren't in the USA, you can point them to the international directory at http://www.iasp.info/resources/Crisis_Centres/ .
It's better for the community not to create a big comment thread about a sucidal message or story - so you may want to delete it, or at least protect it (after giving the links above). And, of course, you can contact us at any time via Special:Contact if something is posted on the wiki that concerns you.
You also need to be careful to look after yourselves. If this is distressing you, you may want to consider protecting yourself by stepping away from the situation. You should also consider asking for help from family or friends offline. If you are under 18, please consider talking to your parents. The helplines above are also available for friends of those in crisis, so you can call them if you need to talk things through.
I won't be around a lot in the next few days, but I'll try to drop in to answer any questions


text:
About the Book
This morning, I drove my 5-year-old daughter to her school. When we drove through the mountains on toll road 241, we saw fog in front of us. Soon we drove into it.
My daughter called the fog "a little cloud" and she told me her story about what had happened.
I like her story so we decided to write it down and share with everyone.
Features & Details
- Category Children
Small Square, 7×7 in, 18×18 cm
24 Pages
- Publish Date Nov 09, 2009
- Tags kids author, kids story
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|Page (1) of 1 - 09/22/08
|email article
|print page
NewBlueFX Introduces "Video Essentials" Effects Plugin SuiteThe "Swiss Army Knife" of Video Effects Collections (September 22, 2008)
DMN Newswire--2008-9-22-- NewBlue, Inc. announces NewBlue Video Essentials, a comprehensive collection of NewBlueFX video plugins designed to enhance, optimize, and accelerate productivity and workflow. Featuring an indispensable toolbox of 10 distinct video effects plugins, NewBlue Video Essentials aids video professionals and enthusiasts in repairing, refining and improving their video.
NewBlue Video Essentials joins the companys highly-regarded product line of 14 exclusive video effects plugins, video transitions and audio filters. The product is available for all major video editing software platforms, including Adobe After Effects, Adobe Premiere, Adobe Premiere Elements, Adobe Premiere Pro, Apple Final Cut Pro, Apple Final Cut Express, Avid Media Composer, Avid NewsCutter, Avid Symphony, Avid Xpress, Avid Liquid, Corel (formerly Ulead) VideoStudio, Pinnacle Studio, Sony Vegas, Sony Vegas Movie Studio and Thomson Grass Valley EDIUS. The collection is value-priced at $79.95.
"NewBlue Video Essentials is an incredible value, but dont be fooled by its aggressive pricing," explains Paul Devermann, VP of Business Development. "This suite of video effects plugins offers critical tools to get the job done. Nowhere else will you find such a powerful set of truly useful tools for less than $100, much less $79.95."
Included in NewBlue Video Essentials are:
- Color Fixer Plus, which provides a quick and easy way to fix color balance. It can also adjust the saturation, brightness, and film gamma.
- Crop Borders, which quickly and easily eliminates unnecessary video borders.
- Detail Enhancer, which strengthens the lines and edges in the video image, bringing out detail in a dull or foggy scene and resulting in a clearer picture.
- Flash Remover, which automatically senses camera flashes and removes them from the video.
- Pixelator, which replaces an oval area on the screen with large colored blocks, obscuring the underlying image. This can be used to obscure a face to maintain anonymity.
- Sharpen, which refines the video image, enhancing the definition.
- Soft Focus, which gently blurs the video image.
- Tint, which changes the coloring and light behavior of the video image. It provides control over the tinting, color saturation, brightness, and has the option of adding the lighting depth of film.
- Touch Up, which smoothes the image, removing subtle blemishes from the video, while maintaining strong details. Touch Up is a great way to clean up an image to make it more appealing.
- Video Tuneup, which combines four very useful image adjustment filters for quick and easy fine (or not so fine) tuning of the image.
Users can purchase NewBlue Video Essentials directly from the company's website at www.newbluefx.com/video-essentials.html. A fully-functional trial version is available for download, as well.
About NewBlue, Inc.:
NewBlue, Inc. develops innovative audio, video and multimedia technologies for leading companies throughout the world. Founded in early 2002, NewBlue creates and licenses a range of proprietary technologies - including a series of NewBlueFX video technologies, the NewBlue Audio Engine and Audiomatrix technology platform - that meet the varied multimedia needs of mid-and large-sized companies. Experienced developers, musicians, artists, and software professionals with a unique and commanding set of skills, experience and talent comprise the NewBlue team.
The company unveiled its NewBlueFX (http://www.newbluefx.com) product line in 2006 to meet the needs of digital video editing enthusiasts. The NewBlueFX collection of software plug-ins includes special audio and video effects, such as audio filters, noise reduction, equalization, compression and dozens of sophisticated graphic filters and transitions. To date, the NewBlueFX line includes 5 audio-oriented plug-in collections and 8 video-oriented effects and transitions collections for the Adobe Premiere, Avid Liquid, Avid Media Composer, Avid Xpress Pro, Pinnacle Studio and Sony Vegas desktop video product lines, as well as AVCHD UpShift, an AVCHD conversion utility created in conjunction with VASST.
For further information on NewBlueFX, please see http://www.newbluefx.com/media-kit.html.
Page: 1
Related Keywords:newbluefx, video plugins, video effects, newblue, video essentials, plugins, plug-ins


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What is JotForm?
JotForm is a free online form builder which helps you create online forms without writing a single line of code. No sign-up required.
At JotForm, we want to make sure that you're getting the online form builder help that you need. Our friendly customer support team is available 24/7.
We believe that if one user has a question, there could be more users who may have the same question. This is why many of our support forum threads are public and available to be searched and viewed. If you'd like help immediately, feel free to search for a similar question, or submit your question or concern.
cancellazione accountAsked by SirGlz on October 04, 2016 at 12:53 PM
vorrei la cancellazione del mio account e di tutti i dati relativi ad esso causo inutilizzo del servizio
cordiali saluti
JotForm Support
As per your request, your account "SirGlz" has been permanently deleted. Thank you for using JotForm.


text:
Born in 1972 - France
Born in 1972, French-Spanish painter Franck Muracciole is graduated from institute of the Visual Arts of Orléans, France. Over the course of several years he worked in Graphic Designer and was at the same time a professional painter, but later decided to concentrate on his paintings exclusively.
He has had numerous shows, especially in Marrakech, where he was invited by the Ministry of Culture. He gave a new direction to his work, creating the "gentle slope", an artistic and architectural idea that brings together rigorous geometry and minimalist poetry.
Franck Muracciole creates veritable constructions, by seeking (literally) their equilibrium point, and they become timeless landscapes with no reference, that induce an unconventional type of contemplation.
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David Paisley grew up in Glen Village near Falkirk with his mother and his five brothers. Shy and with low self-esteem David was bullied at primary school because of his poor background. Even though he had 'a few girlfriends' he was always more aware that he was attracted to boys and at 15 headed to a gay youth group where he eventually met his first boyfriend. At 17, he went to Glasgow University to study Physics (and later to Caledonian university to study Optometry) where he began to become more confident and at 18, finally came out to his family who were very supportive, even helping him start a grassroots website to combat the "Keep the Clause" campaign. It was during his gap year that David got his first taste of acting when he appeared in a community workshop, but he was unsure about pursuing acting as a career, and continued to stay at university until he heard about an open audition for a show called Tinsel Town. After a lot of coaxing from friends he auditioned and landed the part of 17-year-old Ryan Taylor who falls in love with a man twice his age. The role brought him into the public eye and after appearing in the second series of Tinsel Town (as well as landing a guest spot on As If and appearing in a few theatre productions) David landed the part of gay midwife Ben Saunders in BBC1's popular medical soap Holby City. During his time on the show, his character became involved in one of the show's first major 'cross-over' storylines with its sister show Casualty, where his kiss with his on-screen boyfriend attracted 114 complaints from viewers. But having relocated to London, David soon began to miss his friends, family and partner and decided to leave the show in 2003 to move back up to Glasgow. David and his boyfriend Alex, then went traveling for year in Brazil, giving him some time off. Now back in the UK, next up for David is trying to help get the film adaptation of David Leavitt's While England Sleeps up and running, in which he will take the lead role of Edward Phelan.
Name: David Paisley
Known for: Tinsel Town
BirthDay: 02, Feb ,1979


text:
English Bulldog Faq
When you arrive home with your puppy, remember - your puppy is a baby Bulldog. Like all babies, he needs lots of love and cuddling, lots of rest and sleep, lots of love and cuddling, lots of good, nourishing food and more love and cuddling. Moving to a new home, leaving his dam and littermates and the only humans he has ever really known is a very traumatic experience for the puppy, so try to make the move as easy as possible for him. For the first couple of weeks, try to change his life as little as possible. Follow the breeders feeding routine. The same times, the same amount, the same brand of food, the same supplements. Feed him in the same place at each meal. Be sure he has a special area all his own for his bed. Give him lots and lots of cuddling and petting. Do not let him play so long and hard that he becomes exhausted.
Are Bulldogs for You?
Why Do Bulldogs Cost So Much?
If your first question is PRICE.maybe this is not the breed that you should be looking into.In order to breed HIGH QUALITY and HEALTHY bulldogs it is NOT cheap!
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The history of the Spanish heterodox would be incomplete without the figure of Antonio Escohotado. Born in Madrid in 1941, he carries with a kind of ironic dignity the fact that he his always associated with an essay that has never ceased to be reedited. His Historia de las drogas includes some of his character and mind traits: the insatiable curiosity for the travels of body and intelligence. If thinking means thinking critically, putting in doubt the establishment in any of its representations, Antonio Escohotado has taken to its limit this vice of thinking independently with all its consequences. His attitude has only puzzled those who consider him "one of their own", something that is disturbing for someone who does not to like be seen as a preacher. This is why he has puzzled and perplexed, and even irritated, travel companions of all ideological sides.
He prefers to go on his own, as he has always done. This is why he has spent 14 years putting his heart and soul into exposing with full conscience those he calls the enemies of commerce (From the title of his work Los enemigos del comercio: Una historia moral de la propiedad). He has published until now two documented, extensive, and provocative installments. Due to the publication of the second volume, he received me with great cordiality at his home in La Navata. We had not met before, but it was a pleasure to watch him thinking out loud. From that interview, which was published in the newspaper ABC, I remember two pearls worded by the same person who after flirting with Communism, has become a defender of Liberalism: "The wish to kill was higher in Marx than in Stalin" and "Utopia, on top of being foolish, is inmoral". Essayist and university professor, law, philosophy, and sociology have been his most powerful magnets. We should not forget among his works La conciencia infeliz. Ensayo sobre la filosofía de la religión de Hegel; Caos y orden; Marcuse: utopía y razón; Majestades, crímenes y víctimas; and Sesenta semanas en el trópico.


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This book provides a detailed understanding of the broad issues in artificial intelligence and a useful survey of current AI technology. The author delivers broad coverage of innovative representational techniques, including neural networks, image processing, and probabilistic reasoning, alongside the traditional methods of symbolic reasoning. AI algorithms are described in detailed prose in the text and fully implemented in LISP at the ends of chapters. A stand-alone LISP chapter makes an excellent reference and refresher. Each chapter includes a detailed description of an AI application.
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18019 downloads
17627 downloads
17472 downloads
16234 downloads
7683 downloads
This game port has a Crossover Alternative! You can try CrossOver and use it instead if you prefer. Linux users can use this to play as well.
If you already have CrossOver installed, you can install it right now:
If you already Porting Kit installed, press the button below to start the installation:
GOG install instructions:
Make sure before clicking "INSTALL NOW" that you have downloaded the setup files from your GOG library after purchase, into your download folder, so Porting Kit can start the installation automatically. You will be prompted to install the game like if you were in Windows.
Port description:
This WSI file will create a Wrapper and automatically download and install the Windows Origin into that Wrapper. Then when Origin is launched, you can add the origin key of Medal of Honor - Pacific Assault Click "Download" to download and create the Wrapper. For questions and help check the Help/FAQ tab in the Porting Kit.
Game description:
Step into the boots of Marine Private Tom Conlin, as you fight your way through the iconic battles of World War II. Work alone and with the help of squad members to complete missions. As squad members gain experience, they develop their own personalities and fight more efficiently. This first-person-shooter features incredible missions, weapons, and vehicles that put you in the middle of the fight.
- The free Porting Kit app
- A two Button USB mouse with scroll-wheel (recommended)
- The Origin version of Medal of Honor - Pacific Assault
Config Notes:
After install and restart of Origin and when you launch the game, the launcher will appear then first click "configure" to set the resolution and gfx settings.
- For intel HD GFX cards you must choose/select Pixel Shader 1.1!!
- Intel Iris/Nvidia/AMD Radeon will work fine with Pixel Shader 2.0
- Multiplayer using LAN works great!! (or use Hamachi or something like that)
- Origin has still few bugs. First turn off "in game Origin" in the origin preferences before play.
- Second. Installation won't end properly (it keeps saying installing). After a few minutes you can quit origin and restart and the game will launch just fine.


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Pigtail, Lamp Socket, Single Contact
GROTE| Zoro #: G2194376| Mfr #: 68080
Zoro #: G2194376Mfr. Part #: 68080
$1.99 /ea
Orders over $50.00 ship free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G2194376 Mfr #: 68080
|Wire Type: Copper
|Min. Wire Size: 10 AWG
|Type: Lamp Socket, Single Contact, Blunt Cut
|Length: 9-1/2"
|Item: Pigtail
|Connector Type: Green
|Country of Origin (subject to change): Taiwan
Product Description
Pigtail, Lamp Socket, Single Contact, Blunt Cut, Connector Type Green, Min. Wire Size 10 AWG, Wire Type Copper, Length 9-1/2 In.


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Question: Look at the countries on PengAtlas Map 4 3 Suppose your
Look at the countries on PengAtlas Map 4.3. Suppose your multinational team consists of people from these countries. In your opinion, is it possible to have too much diversity?
View Solution:
View Solution:
Answer to relevant QuestionsAfter watching the video on New Balance, discuss the following:1. What will determine the success or failure of New Balance?2. What view of globalization is suggested through the New Balance Company?3. What impact will ...Regarding the two countries with the largest labor force shown on PengAtlas Map 4.3, what advantage does the large size provide? What is the disadvantage? After watching the video on expatriates, discuss the following:1. What kind of staffing approach is being used by Dubai? Explain.2. What does Kevin O'Neal, as an expatriate, bring to Dubai?3. What characteristics do ...Your privately owned company consistently balances the interests of business freedom and labor freedom in its operations. As such, it has become an example for other firms worldwide to emulate. Since the tension between ...Compare PengAtlas Map. 4.5 With Map 1.1. Suppose your firm is located in a developed economy that is considering curbing carbon emissions, which could create severe problems for your firm and threaten its existence. Would ...
Post your question


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Some women feel clearly called to work outside the home.
Some women have found themselves needing to work to make ends meet.
Some women are single and have no other source of income so have to work.
My experience is different from yours and yours from mine.
But I do hope what I share in this post can be something that we can all connect with and find hope from.
I am excited to share this because it is something that is changing the way I view my work. I do love what I do. I am lucky in that my work is meaningful and I use my gifts and skills and feel good about the work. But what I don't feel good about, at times, is the void of time I am away from my kids. My kids are now both in school, so it is a bit of a different feeling; however- my youngest who is in pre-school still gets to me. There are days where he wants me to stay home, where he asks me not to go to work and it hurts. There are days I wish I worked only half a day so I could help out in the school and be more present. My older son is going through a lot and I wish I understood what his life was like in school- these are the days I think I should be homeschooling. I have doubts, I have questions, I'm sure some of you can relate.
Usually on those particularly difficult days, I feel particularly distant, anxious or sad about something going on in the lives of my kids and I feel like maybe I should be home with them to "fix it" or to help them sort it out. On days like that I do my best, I pray with them, I pray for them and I check in at the end of the day and typically I see how the Lord has met the needs of my children and all is well.
But somedays the tension remains. I wake up with it, I feel it throughout the day and I feel it at the end of the day.
So I have started asking God to help me see this tension in a new way. Is it there because I truly am not supposed to be working? Do I need help with something? Am I focusing too much on the house, dinner, vs. being present with the kids? Am I missing something that God is wanting me to do? I don't feel convicted of sin. I do know that.
I prayed through these questions and the Holy Spirit led me to a few specific things but also to an overarching idea. I was looking at needs and what I was doing to meet those needs, all day, every day. My focus was on what I was doing and accomplishing and then determining/assessing my success based on that. Not an unusual thing- most women do this, whether you stay at home or work. We want to do what is right and best for our spouses, our children and our home.
But what the Lord led me to grasp is something even better. To start looking at the tension I feel (which really boils down to what I am not able to accomplish, control or change), as an opportunity for sanctification.
Sanctification is God's will for us. 1 Thessalonians 4:3 says- "For this is the will of God, your sanctification…".
The word sanctification is related to the word saint; both words have to do with holiness.
To "sanctify" something is to set it apart for special use; to "sanctify" a person is to make him holy.
Sanctification is a state of separation unto God; all believers enter this state when they are born of God.
1 Corinthians 1:30- "You are in Christ Jesus, who became to us wisdom from God, righteousness and sanctification and redemption." This is positional sanctification. It is a done deal upon belief in Jesus.
How would you see each day- if you looked at it in this way?
If you woke up in the morning knowing that this day you have before you is on purpose.
That you have a purpose- which is to seek holiness, to become sanctified and to apply the Word of God to all areas of your life.
Your life can be a stunningly beautiful witness for the Lord, right where you are, right now. Believe it sisters and pursue it. Instead of working being a burden, maybe we can see it as a blessing and as a tool that the Lord will use to make us more like Him!
When the tension comes, lay it down before Jesus and ask Him to USE it to make you holy and more like Christ. I hope this encourages you!


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there is a guy and he told me he liked me a month ago. i told him i liked him back but he never asked me out. he isn't the player type of boy tho. i dont know why that is. weve been talking a lot and talking about what we wanted to do with the fact that we like eachother. he said he wasn't ready for a relationship yet so i told him i would wait. a few days ago we kissed and since we barely talk. it was my first kiss and he knew it. also, one of my friends had a crush on him before me so i didn't want to get involved but i did and he finds her super unattractive but when she heard we made out she totally flipped and she became all bossy and bitch. and she told the guy that he needs to ask me out and we need to have a relationship and he should be more of a gentleman. oh and the guy is totally awkward but the cute kinda awkward. What am i supposed to do? i want a relationship but i know he wants to keep this to a hook up level.
Most Helpful Guy
You ask him out? Is that not an option?00|00|0
but he told my friend he doesn't wanna date yet cuz he doesn't want a relationship yet
- Show AllShow Less
Well that's what usually girls do, but I don't think it will help you in this case.
yah i realized. thats my i posted this question... :D
Most Helpful Girl
Just ask him out00|00|0
i really wish but he told my friend he wouldn't wanna have a relationship maybe later cuz he likes my personality. also. do u have any clue why he ignores me sometimes. he sees my message and he doesn't reply and i usually ask questions like how r u or what r u doing.


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All it Takes is a Little Paint
Nelson talks with City Repair co-founder Mark Lakeman, who was behind the citizen movement to create community through painted intersections (see below):
"At its core, intersection painting is about community empowerment. In Portland, City Repair doesn't seek out neighborhoods to encourage residents to paint the street. They wait for neighbors to come to them. City Repair will then work as facilitators, helping residents choose a design and encouraging them as they knock on doors to garner support for the painting. While the painted mural is a beautiful end product, it's the relationships and sense of community formed through the process that makes these places become villages within the city."
Sunnyside Piazza in Portland. Photo: donkeycart.


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Veteran Technology Consulting Firm Applies Open Source Technologies to Help Customers Reduce Costs and Mitigate Risk across the Enterprise.
Aras®, the leading provider of enterprise open source Product Lifecycle Management (PLM) software solutions, today announced that PSC Group, a business technology consulting firm headquartered in Chicago, IL, has joined the Aras Partner Program. PSC will apply its expertise with open source and Microsoft technologies, and its in-depth knowledge in planning, developing and deploying enterprise information solutions, to the Aras advanced PLM solution suite.
For more than 20 years PSC has been delivering high value solutions designed to reduce costs and mitigate risk. The company prides itself on listening to the needs of its clients and developing solutions that deliver significant return on investment and enable businesses to achieve their strategic objectives.
"PSC is very excited to be partnering with Aras. Teaming with Aras will enable us to leverage our expertise in consumer goods manufacturing to help companies drive business value in non-traditional PLM areas of their company", said Darryl Poore, Director of Advisory Services for PSC.
"PSC's commitment to excellence and customer service, combined with their in-depth knowledge of open source, service oriented architecture and other technologies make them an ideal partner for Aras. We welcome them to the Aras Community and the Aras Partner Program", said Peter Schroer, President of Aras.
Aug 10, 2011
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Ł24.49 Was Ł69.99
A complete shaving set including bowl. Superb steel implements finished in a slight matt black to create a sleek, modern look to a traditional design.
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Tuff Stuff GM LT1 Water Pump Chrome 1362A High-volume Mechanical Water Pump
Clockwise Aluminum Chrome Chevrolet/Pontiac 4.3L LT/5.7L LTPit Stop USA offers Tuff Stuff GM LT1 Water Pump Chrome 1362A at low everyday prices. Be sure to check out all of our products from Tuff Stuff Performance including Tuff Stuff Performance Small Block Chevy Water Pumps.
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Leptin contributes to the pathogenesis of atherosclerosis. Ang II (angiotensin II), a proatherogenic cytokine, increases leptin synthesis in cultured adipocytes. Statin suppresses leptin expression in adipocytes and human coronary artery endothelial cells. However, the effect of Ang II and statin on leptin expression in VSMCs (vascular smooth muscle cells), the major cell types in atheroma, is poorly understood. Thus the aim of the present study was to investigate the molecular mechanism of atorvastatin for reducing leptin expression after Ang II stimulation in VSMCs. VSMCs from human coronary artery were cultured. Ang II stimulation increased leptin protein and mRNA and phospho-JNK (c-Jun N-terminal kinase) expression. Exogenous addition of Dp44mT (2,2′-dipyridyl-N,N-dimethylsemicarbazone) and mevalonate increased leptin protein expression similarly to Ang II. Atorvastatin, SP600125, JNK siRNA (small interfering RNA) and NAC (N-acetylcysteine) completely attenuated the leptin and phospho-JNK protein expression induced by Ang II. Ang II significantly increased ROS (reactive oxygen species) formation in human VSMCs. Addition of atorvastatin and NAC significantly attenuated the formation of ROS induced by Ang II. Addition of atorvastatin and SP600125 inhibited the phosphorylation of Rac1 induced by Ang II. The gel shift and promoter activity assay showed that Ang II increased AP-1 (activator protein-1)-binding activity and leptin promoter activity, while SP600125, NAC and atorvastatin inhibited the AP-1-binding activity and leptin promoter activity induced by Ang II. Ang II significantly increased the migration and proliferation of cultured VSMCs, while addition of atorvastatin, SP600125, NAC and leptin siRNA before Ang II stimulation significantly inhibited the migration and proliferation of VSMCs induced by Ang II. Ang II significantly increased secretion of leptin from human VSMCs, and addition of SP600125, atorvastatin and NAC before Ang II stimulation almost completely inhibited the leptin secretion induced by Ang II. In conclusion, Ang II induces leptin expression in human VSMCs, and atorvastatin could inhibit the leptin expression induced by Ang II. The inhibitory effect of atorvastatin on Ang II-induced leptin expression was mediated by Rac, ROS and JNK pathways.
- angiotensin II
- atherosclerosis
- leptin
- smooth muscle cell
- statin
Leptin, the product of the obesity gene, is a 16 kDa plasma protein mainly secreted by adipocytes and is involved in the regulation of appetite and energy metabolism [1,2]. It has peripheral actions to stimulate vascular inflammation, oxidative stress and VSMC (vascular smooth muscle cell) hypertrophy, and contributes to atherosclerosis [3,4]. Several studies have shown an independent interaction between high leptin and atherosclerosis, myocardial infarction, stroke and coronary artery intima-media thickness, suggesting that high levels of leptin may increase cardiovascular risk [5–7]. Recently, Bodary et al. [8] have shown that direct administration of leptin in apolipoprotein E-deficient mice results in increased atherosclerosis. Recent reports have shown leptin production by non-adipose cells, such as vascular endothelial cells and SMCs (smooth muscle cells) [9,10], indicating that leptin may be an inducible, locally produced, proatherogenic mediator.
Leptin increases oxidative stress in vascular cells [11] and promotes VSMC migration and proliferation [12], decreases arterial distensibility [13] and contributes to obesity-associated hypertension. Ang II (angiotensin II), a proatherogenic cytokine and local mediator of inflammation, increases leptin synthesis in cultured adipocytes and in rats in vivo [14,15]. However, the effect of Ang II on leptin expression in VSMCs, the major cell types in atheroma, is poorly understood.
Statin, a potent inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase, has been shown to reduce blood leptin levels in hypercholesterolaemic rabbits and in patients with CAD (coronary artery disease) [16,17]. Statin also suppresses leptin expression in adipocytes and human coronary artery endothelial cells [18,19]. The effect of statin on leptin expression in VSMCs is poorly understood. Ang II has been shown to increase leptin expression in fat cells via the MAPK (mitogen-activated protein) kinase and ERK1/2 (extracellular-signal-regulated kinase 1/2)-dependent pathway [14]. The pleiotropic effect of statin is mainly via the Rac1 pathway. Ang II plays a crucial role in atherosclerosis. We hypothesize that Ang II may induce leptin expression in VSMCs and statin may suppress leptin expression induced by Ang II via MAPK and Rac1 pathway. Thus the aim of present study was to investigate the molecular mechanism of leptin expression in VSMCs under atorvastatin treatment with Ang II stimulation.
Atorvastatin, a calcium salt of a penta-substituted pryole, was supplied by Pfizer. A 10 mmol/l stock solution was made in 100% DMSO. Ang II was purchased from Bachem, Torrance, CA, U.S.A. Recombinant leptin protein was purchased from PeproTech, Rocky Hill, NJ, U.S.A. Mevalonate was purchased from Sigma, St Louis, MO, U.S.A.; PD98059 (a specific and potent inhibitor of ERK kinase), SB203580 (a highly specific, cell-permeable inhibitor of p38 kinase), SP600125 [a potent, cell-permeable, selective and reversible inhibitor of JNK (c-Jun N-terminal kinase)], NAC (N-acetylcysteine; a free radical scavenger) and NSC23766 (Rac1 inhibitor; a cell-permeable pyrimidine compound that specifically inhibits Rac1) were purchased from Calbiochem®, San Diego, CA, U.S.A. These inhibitors were added 30 min before Ang II stimulation. Dp44mT (2,2′-dipyridyl-N,N-dimethylsemicarbazone), an iron chelator to generate ROS (reactive oxygen species), and anisomycin, a MAPK activator, were purchased from Calbiochem®.
VSMC culture
HCASMCs (human coronary artery smooth muscle cells) were originally obtained from PromoCell GmbH (Heidelberg, Germany). The cells were cultured in SMC growth medium supplemented with 10% fetal bovine serum, 100 units/ml penicillin and 100 μg/ml streptomycin at 37 °C in a humidified atmosphere of 5% CO2 in air. Cells were grown to 80–90% confluence in 10 cm2 culture dishes and were sub-cultured at a ratio of 1:2. When confluent, SMCs monolayers were passaged every 6–7 days after trypsinization and were used for experiments from the third to sixth passages. Cells of these third to sixth passages were incubated for an additional 2 days to render them quiescent before the initiation of each experiment.
Western blot analysis
Cells were homogenized in modified RIPA buffer [50 mM Tris/HCl (pH 7.4), 1% Nonidet P40, 0.25% sodium deoxycholate, 150 mM NaCl, 1 mM EDTA, 1 mM PMSF, 1 μg/ml each of aprotinin, leupeptin and pepstatin, 1 mM sodium orthovanadate and 1 mM sodium fluoride] and Western blot analysis was performed as previously described [20,21]. All Western blots were quantified using densitometry. Monoclonal anti-α-tubulin antibody (Sigma), polyclonal anti-leptin and monoclonal anti-phospho-JNK antibodies (Santa Cruz Biotechnology), polyclonal anti-JNK and polyclonal anti-Rac antibodies (Cell Signaling, Beverly, MA, U.S.A.) were used.
Real-time PCR
Total RNA from cultured HCASMCs (human coronary artery SMCs) was extracted using the single-step acid guanidinium thiocyanate/phenol/chloroform extraction method. Real-time reverse transcription-PCR was performed as previously described [21]. The human leptin primers were 5′-GTGCCTTCCAGTAGTATCTT-3′ and 5′-AGCCACAAGAATCCGCACAGG-3′. A Lightcycler (Roche Diagnostics, Mannheim, Germany) was used for real-time PCR as previously described [21]. Amplification, fluorescence detection and post-processing calculation were performed using the Lightcycler apparatus. Individual PCR products were analysed for DNA sequence to confirm the purity of the product.
Measurement of leptin concentration
Conditioned media from Ang II-treated cells and those from control (non-Ang II-treated) were collected for leptin measurement. The level of leptin was measured by a quantitative sandwich enzyme immunoassay technique (R&D Systems, Minneapolis, MN, U.S.A.). The lower limit of detection of leptin was 15.6 pg/ml.
Intracellular ROS was assessed by the ROS-specific probe CM-H2DCFDA [5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester]. CM-H2DCFDA (20 μM) was pretreated in the cultured cells for 30 min and incubated at 37 °C. After Ang II stimulation, cells were collected by trypsinization and resuspended in PBS medium. ROS assay was performed according to the manufacturer's instruction (Invitrogen, Eugene, OR, U.S.A.). Fluorescence signals were obtained with a fluorescence conversion microscope (Nikon DIAPHOT 300) and assayed by its image processing and analysis software.
RNA interference
Cells were transfected with 800 ng of JNK annealed siRNA (small interfering RNA) or leptin siRNA oligonucleotide (Dharmacon, Lafayette, CO, U.S.A.). JNK or leptin siRNA is a target-specific 20–25 nt siRNA designed to knock down gene expression. The JNK sense of siRNA sequences was 5′-CGUGGAUUUAUGGUCUGUGdTdT. Leptin sense of siRNA sequences was 5′-CCAAAUAUCCAACGACCUG-3′. As a negative control, a non-targeting siRNA (scrambled siRNA) purchased from Dharmacon was used. VSMCs were transfected with siRNA oligonucleotides using Effectene Transfection Reagent as suggested by the manufacturer (Qiagen, Valencia, CA, U.S.A.).
EMSA (electrophoretic mobility-shift assay)
Nuclear protein concentrations from HCASMCs were determined by Bio-Rad protein assay. Consensus and control oligonucleotides (Santa Cruz Biotechnology) were labelled by polynucleotides kinase incorporation of [γ-32P]ATP. After the oligonucleotide was radiolabelled, the nuclear extracts (4 μg of protein in 2 μl of nuclear extract) were mixed with 20 pmol of the appropriate [γ-32P]ATP-labelled consensus or mutant oligonucleotide in a total volume of 20 μl for 30 min at room temperature (22 °C). The samples were then resolved on a 4% polyacrylamide gel. Gels were dried and imaged by autoradiography. Controls were performed in each case with mutant oligonucleotides or unlabelled oligonucleotides to compete with labelled sequences.
Promoter activity assay
Leptin gene was amplified with specific forward and reverse primers. The amplified product was digested with MluI and BglII restriction enzymes and ligated into pGL3-basic luciferase plasmid vector (Promega) digested with the same enzymes. Site-specific mutations were confirmed by DNA sequencing. Plasmids were transfected into cells using a low-pressure-accelerated gene gun (Bioware Technologies, Taipei, Taiwan), essentially following the protocol from the manufacturer. Test plasmid at 2 μg and control plasmid (pGL4-Renilla luciferase), 0.02 μg, were co-transfected with a gene gun in each well, and then were replaced by the normal culture medium. Following a time course of Ang II treatment, cell extracts were prepared using Dual-Luciferase Reporter Assay System (Promega) and were measured for dual luciferase activity by a luminometer (Turner Designs, Sunnyvale, CA, U.S.A.).
Migration assay
The migration activity of HCASMCs was determined using the growth-factor-reduced Matrigel invasion system (Becton Dickinson) following the protocol provided by the manufacturer. Migration assay was performed as previously described [22]. 5×104 SMCs were seeded on top of an ECMatrix gel (Chemicon International, Temecula, CA, U.S.A.) prepared as described previously [23]. Cells were then incubated at 37 °C for 18 h. Three different phase-contrast microscopic high-power fields per well were photographed. The migratory VSMCs with positive stain were counted and the observer was blind to the experiment.
Proliferation assay
The proliferation of HCASMCs was determined using [3H]thymidine incorporation. SMCs were seeded on ViewPlate (Packard Instrument, Meriden, CT, U.S.A.) at a density of 5×103 cells/well in serum-free medium. Thymidine uptake was studied by an addition of 500 nCi/ml [3H]thymidine (PerkinElmer, Boston, MA, U.S.A.) for 6 and 18 h. Cells were washed twice with PBS. Non-specific uptake was studied in the presence of 10 μM cytochalasin B and subtracted from the measured value. MicroScint-20 (50 μl) was added, and the plate was read with TopCount (Packard Instrument).
Statistical analysis
The results are expressed as means±S.D. Statistical significance was performed with ANOVA (GraphPad Software, San Diego, CA, U.S.A.). The Dunnett's test was used to compare multiple groups to a single control group. The Tukey–Kramer comparison test was used for pairwise comparisons between multiple groups after the ANOVA. A value of P<0.05 was considered to denote statistical significance.
Ang II increases leptin expression in cultured VSMCs
Western blot was used first to investigate the effect of Ang II on leptin expression on HCASMCs. Leptin protein expression was significantly induced at 4 h after Ang II stimulation, maximally induced at 18 h, and remained elevated for 24 h (Figures 1A and 1B). The leptin protein expression was confirmed with another antibody that reacts to the N-terminus of leptin of human origin purchased from Santa Cruz Biotechnology. The expression of leptin mRNA was significantly induced by Ang II from 4 to 24 h of stimulation (Figure 1C).
Atorvastatin inhibits the effect of Ang II on leptin expression via JNK and Rac1 pathways
To investigate the atorvastatin inhibitory mechanism on induction of leptin by Ang II, JNK and Rac pathways were studied. PD98059 (50 μM), a potent inhibitor of p42/p44 MAPK and SB203580 (3 μM), a potent inhibitor of p38 MAPK had partial inhibition effect on leptin protein expression induced by Ang II (Figures 2A and 2B). SP600125 (20 μM), a potent inhibitor of JNK and JNK siRNA completely blocked the leptin protein expression induced by Ang II. Exogenous addition of Dp44mT increased leptin protein expression similarly to Ang II and NAC (500 μM), an antioxidant scavenger, completely blocked the leptin expression induced by Ang II. These findings indicate that the JNK and ROS pathways are the main signalling pathways mediating the induction of leptin protein expression by Ang II. To test whether atorvastatin can inhibit the effect of Ang II on leptin expression in HCASMCs, different doses of atorvastatin were added before Ang II stimulation. As shown in Figures 2(C) and 2(D), atorvastatin inhibited the leptin protein expression induced by Ang II in a dose-dependent manner. Atorvastatin (10 μM) almost completely inhibited the leptin protein expression induced by Ang II. The addition of mevalonate at 200 μM for 18 h had an effect similar to Ang II stimulation in leptin protein expression (Figures 2E and 2F). However, atorvastatin did not have any effect on leptin protein expression induced by mevalonate. Atorvastatin alone had a neutral effect on leptin expression similar to control cells. This finding suggested that mevalonate has proinflammatory effect on leptin expression in HCASMCs and atorvastatin inhibited the Ang II-induced leptin expression via the HMG-CoA reductase pathway.
Rac1 inhibitor (50 μM) almost completely blocked the effect of Ang II on leptin induction. Addition of Rac1 inhibitor did not affect the leptin expression induced by Dp44mT (Figures 2E and 2F). Anisomycin (20 μM) significantly increased leptin protein expression similarly to Ang II (Figures 2G and 2H). Under anisomycin stimulation, addition of atorvastatin and NAC did not have inhibitory effect on leptin protein expression. Under Dp44mT stimulation, atorvastatin did not have an inhibitory effect on leptin expression, while the addition of SP600125 completely attenuated the leptin protein expression induced by Dp44mT (Figures 2G and 2H). The phospho-JNK protein expression was significantly induced by Ang II from 2 to 24 h (Figures 3A and 3B). Atorvastatin, SP600125, JNK siRNA and NAC significantly attenuated the phospho-JNK protein expression induced by Ang II. As shown in Figures 3(C) and 3(D), Ang II induced phosphorylation of Rac1 in a time-dependent manner. Ang II did not have any effect on total Rac1. The addition of atorvastatin and SP600125 inhibited the phosphorylation of Rac1 induced by Ang II. Rac 1 inhibitor completed inhibited the phosphorylation of Rac1.
Ang II significantly increased ROS formation in HCASMCs (Figures 4A and 4B). Exogenous addition of Dp44mT (30 nM) increased ROS formation similarly to Ang II. The addition of atorvastatin and NAC (500 μM) significantly attenuated the formation of ROS induced by Ang II. These results indicate that the Rac1 pathway mediates the inhibitory effect of atorvastatin on leptin expression induced by Ang II. Rac1 was activated by Ang II before ROS formation, and the JNK pathway was activated after ROS formation.
Ang II increases AP-1 (activator protein-1)-binding activity and leptin promoter activity
The EMSA assay showed that Ang II increased AP-1 DNA-protein binding activity (Figure 5). An excess of unlabelled AP-1 oligonucleotide competed with the probe for binding AP-1 protein, whereas an oligonucleotide containing a 2 bp substitution in the AP-1-binding site did not compete for binding. The addition of SP600125, NAC and atorvastatin 30 min before Ang II stimulation abolished DNA–protein binding activity induced by Ang II. Exogenous addition of Dp44mT without Ang II stimulation also increased DNA–protein binding activity. To study whether the leptin expression induced by Ang II is regulated at the transcriptional level, we cloned the promoter region of human leptin (−866~+35) and constructed a luciferase reporter plasmid (pGL3-Luc). The leptin promoter construct contains AP-1, GATA, HIF (hypoxia-inducible factor)-1α, Myc-Max and NF-κB (nuclear factor κB) binding sites. As shown in Figures 5(B) and 5(C), a transient transfection experiment with HCASMCs using this reporter gene revealed that Ang II stimulation for 2 h significantly caused leptin promoter activation. This result indicates that leptin expression is induced at the transcriptional level by Ang II. When the AP-1 binding sites were mutated, the increased promoter activity induced by Ang II was abolished. Moreover, addition of SP600125, NAC and atorvastatin 30 min before Ang II stimulation caused an inhibition of transcription. Dp44mT, like Ang II, also significantly increased the leptin promoter activity. These results suggested that the AP-1-binding site in the leptin promoter is essential for the transcriptional regulation by Ang II and that Ang II regulates the leptin promoter via the JNK and ROS pathways.
Atorvastatin attenuates VSMC migration and proliferation induced by Ang II
To test the effect of Ang II and leptin on the function of VSMCs, the migration activity of HCASMCs was examined. As shown in Figures 6(A) and 6(B), Ang II significantly increased the SMC migration activity as compared with control. Addition of atorvastatin, SP600125, NAC and leptin siRNA significantly abolished the migration activity of SMCs induced by Ang II. Control siRNA did not affect the migration activity of SMCs. Dp44mT had a similar effect on SMC migration activity compared with Ang II. Ang II and leptin recombinant protein for 6 and 18 h stimulation also significantly increased the proliferation of cultured SMCs (Figure 6C). The addition of atorvastatin, SP600125, NAC and leptin siRNA before Ang II stimulation significantly inhibited the proliferation of SMCs induced by Ang II. Dp44mT had a similar effect on SMC proliferation compared with Ang II and leptin. The leptin siRNA almost completely inhibited the leptin protein expression induced by Ang II, while scrambled siRNA did not have the inhibitory effect (see Supplementary Figure S1 at http://www.clinsci.org/cs/122/cs1220033add.htm).
Ang II increases secretion of leptin from HCASMCs
Ang II stimulation for 4–24 h significantly increased the secretion of leptin from HCASMCs (see Supplementary Figure S2 at http://www.clinsci.org/cs/122/cs1220033add.htm). Addition of SP600125, atorvastatin and NAC 30 min before Ang II stimulation almost completely inhibited the leptin secretion induced by Ang II.
In the present study, we demonstrated several significant findings. First, Ang II up-regulates leptin expression in cultured HCASMCs; secondly, Ang II induces secretion of leptin from HCASMCs; thirdly, Rac1, JNK kinase, ROS and AP-1 transcription factor are involved in the signalling pathway of leptin induction; fourthly, atorvastatin inhibits leptin expression induced by Ang II; fifthly, atorvastatin inhibits migration and proliferation of HCASMCs induced by Ang II. Leptin is considered to be a specific adipocyte product. Recent reports [9,10] and our present study have shown leptin production by non-adipose cells. Leptin production by VSMCs was not widely investigated. Sugiyama et al. [10] have reported that a combination of hypoxia and high low-density lipoprotein level conditions induced leptin expression in HCASMCs. Our study is the first one to investigate VSMC leptin in detail. The result in our study may change our conception of leptin from an adipose-tissue-derived circulating adipokine to an inducible, locally produced, proatherogenic mediator.
Higher plasma leptin levels are associated with hypertension, suggesting plasma leptin level as a novel adipose tissue-derived biomarker for hypertension [24,25]. Recently, leptin has been considered to be a possible link between obesity and the development of hypertension [26]. Evidence has suggested that leptin is responsible for the initiation and progression of atherosclerosis. Leptin may become a potential therapeutic target for the treatment of atherosclerosis. Statins exert a direct inhibitory effect on leptin secretion from adipocytes, reducing plasma leptin levels, which plays an important role in atherogenesis [3]. Statin can significantly reduce plasma levels of leptin in patients with Type 2 diabetes [27] and in patients with CAD, independent of its lipid-lowering action [17]. Statins have been shown to reduce lipid-lowering effects as well as pleiotropic properties. Statins have been shown to reduce leptin expression in human coronary artery endothelial cells by reducing C-reactive protein production [19] and in adipocytes by inhibition of protein prenylation [18]. These results implicate that statins may control inflammatory responses by inhibiting leptin expression. In the present study, Ang II was able to increase leptin secretion from VSMCs and atorvastatin significantly inhibited the leptin secretion induced by Ang II.
Ang II has been shown to promote leptin production in fat cells in a dose- and time-dependent fashion [28]. In the present study, we have demonstrated that Ang II-induced leptin protein and mRNA expression in HCASMCs and atorvastatin decreased Ang II-induced leptin expression in a dose-dependent manner. The induction of leptin protein by Ang II was largely mediated by the JNK kinase pathway because the specific and potent inhibitors of an upstream JNK kinase, SP600125 and JNK siRNA, inhibited the induction of leptin protein. Atorvastatin also inhibited the phosphorylation of Rac induced by Ang II. In the present study, we demonstrated that Ang II stimulation of AP-1 DNA-binding activity required at least phosphorylation of JNK since the JNK inhibitor abolished the AP-1-binding activity. Atorvastatin also attenuated the AP-1-binding activity induced by Ang II. The promoter activity of wild-type leptin promoter after Ang II stimulation was significantly higher than that of AP-1 mutant leptin promoter. This finding indicates that Ang II regulates leptin in rat VSMCs at the transcriptional level and that an AP-1-binding site in the leptin promoter is essential for transcriptional regulation. Taken together, our results indicate that Ang II may increase the AP-1 transcriptional activity in HCASMCs. Leptin induced by Ang II was largely through JNK, Rac and leptin promoter pathways, and atorvastatin could inhibit leptin expression through inhibition of Rac phosphorylation, reduced AP-1 binding activity and leptin promoter activity.
Oxidative stress seems to play a pivotal role in the leptin effect [4]. Statin has been shown to inhibit the sympathetic nervous system through inhibition of ROS in the rostral ventrolateral medulla [29]. The ROS are mainly produced by the AT1 receptor (angiotensin II type 1 receptor). In the present study, Ang II increased ROS formation, and exogenous addition of Dp44mT had a similar effect to Ang II. The increased ROS could be significantly attenuated by atorvastatin and NAC, a free radical scavenger. NAC also inhibited the leptin secretion from HCASMCs induced by Ang II. The inhibition of ROS by atorvastatin in VSMCs may explain the clinical effect of atorvastatin to reduce blood pressure [30].
The effect of leptin on proliferation of SMCs is controversial. A few studies have reported that leptin inhibits cell growth of VSMCs and inhibits proliferation of SMCs induced by Ang II [31–33]. However, more studies have demonstrated that leptin induces proliferation and hypertrophy of VSMCs in cell culture and animal studies [12,34–37]. These contradictory results raise some doubts as regards the potential involvement of leptin in vascular remodelling. Different cell types and cultured conditions may have different results on leptin effect on VSMCs. However, results from clinical studies indicate that leptin increases cardiovascular risk, and plasma leptin levels may become a biomarker for hypertension. Our result also demonstrated that recombinant leptin enhanced migration and proliferation of HCASMCs, both of which could be attenuated by atorvastatin. These results indicate that leptin still seems to be a proatherogenic cytokine in vascular pathophysiology.
Ang II increased leptin secretion from HCASMCs and increased migration and proliferation of HCASMCs. Leptin siRNA inhibited leptin secretion and migration and proliferation of HCASMCs induced by Ang II. This finding indicates that there is an autoregulatory loop of leptin expression. The autoregulatory loop of leptin expression is mediated by JNK and ROS signalling pathways, since both JNK inhibitor and NAC inhibited leptin secretion and migration and proliferation of HCASMCs induced by Ang II.
The pathway that controls induction of leptin expression under Ang II stimulation in HCASMCs and the inhibitory effect of atorvastatin on leptin expression is shown in Figure 7. Our findings provide further evidence for the pleiotropic effect of statins. A better understanding of the detailed mechanisms of statin will provide us with new insight into the prevention and therapeutic development for leptin-induced atherosclerosis that is frequently encountered in patients suffering from CAD.
This work was supported by Pfizer, Taiwan (research grant to H.F.H.) and Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan [grant number SKH-8302-99-DR-02].
Kou-Gi Shyu participated in the design of the study and drafted the paper. Shih-Chung Chen made substantial contributions to conception and design, and analysis and interpretation, of data. Bao-Wei Wang made substantial contributions to conception and design, and acquisition, of data or analysis and interpretation of data. Wen-Pin Cheng made substantial contributions to acquisition of data or analysis and interpretation of data. Huei-Fong Hung participated in the design of the study and final approval of the paper prior to submission.
Abbreviations: Ang II, angiotensin II; AP-1, activator protein-1; CAD, coronary artery disease; CM-H2DCFDA, 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester; Dp44mT, 2,2′-dipyridyl-N,N-dimethylsemicarbazone; HMG-CoA, 3-hydroxy-3-methylglutaryl-CoA; JNK, c-Jun N-terminal kinase; EMSA, electrophoretic mobility-shift assay; ERK, extracellular-signal-regulated kinase; HCASMC, human coronary artery smooth muscle cell; MAPK, mitogen-activated protein kinase; NAC, N-acetylcysteine; ROS, reactive oxygen species; siRNA, small interfering RNA; SMC, smooth muscle cell; VSMC, vascular smooth muscle cell
- © The Authors Journal compilation © 2012 Biochemical Society


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right cheek , week 1
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Paris, France – (The Hosting News) – April 11, 2008 – Hosted security services firm, BrightCloud, Inc., and software vendor and developer of Internet connection sharing products, Entensys, have begun a joint technology partnership to integrate the BrightCloud services into UserGate Security server.
Designed as a complete Internet Sharing software solution for protected Internet access, the BrightCloud Service will be integrated into the UserGate Proxy so that customers can implement web filtering as part of the proxy solution.
Alexander Levchenko, President of Entensys noted, "The integration of the hosted BrightCloud Service with UserGate server provides users with a state of the art web filtering experience for managing their Internet access. This technology partnership shows our commitment to providing our users with a great user experience built upon superior technology covering maximum of existing Internet websites."
Browsing the web, users will be able to implement acceptable internet usage policies appropriate for them. The web page request is handed off to the BrightCloud Service and the BrightCloud Master Database to determine the category of the website, and the integrated UserGate policy engine implement the appropriate policy.
Quinn Curtis, CEO of BrightCloud remarked, "We are very pleased to announce this technology partnership. UserGate is a very successful product in the marketplace, and a perfect fit for the BrightCloud solution. Combining the Entensys product with the hosted BrightCloud Services provides UserGate customers with the security and peace of mind that they are being protected by the next generation of web filtering."
The integrated hosted BrightCloud Service enables UserGate customers to protect themselves from websites that have been compromised as well as to enhance productivity by limiting access to non-productive resources, reduce exposure to legal liability, maximize IT resources by managing access to peer to peer websites, or IM or other internet communication websites. The BrightCloud Master Database, contains over 125 million sites, as well as supports multiple categories and confidence scores for each site. It also provides coverage of the major languages and others, including German, French, Spanish, Chinese, Japanese, Korean, Arabic, Russian, Ukrainian and Armenian.
Entensys Corporation is an international software vendor and developer of Internet connection sharing products, the provider of the popular UserGate Internet security server.
BrightCloud, Inc. is building the next generation web filtering database. BrightCloud provides security vendors with hosted security services that extend the value propositions of web filtering across the internet's Long Tail, which includes both the most popular sites as well as those sites less frequently visited, but visited nonetheless.
To learn more about Entensys, please visit: www.entensys.com.
For more information about BrightCloud, Inc., please visit: www.brightcloud.com.


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Sea level reconstruction: Exploration of methods for combining altimetry with other data to beyond the 20-year altimetric record
- Authors:
- Abstract:
- Ocean satellite altimetry has provided global sets of sea level data for the last two decades, allowing determination of spatial patterns in global sea level. For reconstructions going back further than this period, tide gauge data can be used as a proxy for the model. We examine different methods of combining satellite altimetry and tide gauge data using optimal weighting of tide gauge data, linear regression and EOFs, including automatic quality checks of the tide gauge time series. We attempt to augment the model using various proxies such as climate indices like the NAO and PDO, and investigate alternative transformations such as maximum autocorrelation factors (MAF), which better take into account the spatio-temporal structure of the variation. Whereas a traditional EOF analysis tries to explain as much variance as possible, the MAF transform considers noise to be uncorrelated with a spatially or temporally shifted version of itself, unlike the desired signal which will exhibit autocorrelation. This will be applied to a global dataset, necessitating wrap-around consideration of spatial shifts. Parameters from physical oceanography will be incorporated using the SODA ocean model for a preliminary reference. We will attempt to take into account the uncertainties on thermosteric expansion and on ice sheet contributions. Our focus is a timescale going back approximately 50 years, allowing reasonable global availability of tide gauge data. This allows for better sensitivity analysis with respect to spatial distribution, and tide gauge data are available around the Arctic Ocean, which may be important for a later high-latitude reconstruction.
- Type:
- Conference abstract
- Language:
- English
- Published in:
- 20 Years of Progress in Radar Altimetry Symposium: Abstract Book, 2012
- Main Research Area:
- Science/technology
- Publication Status:
- Published
- Review type:
- Peer Review
- Conference:
- 20 years of Progress in Radar Altimetry, 2012
- Publisher:
- European Space Agency, ESA
- Submission year:
- 2012
- Scientific Level:
- Scientific
- 234152921


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Copy of Writing a Letter
Lesson to recap on skills to write formal or informal letter
Emma Lloydon 28 June 2011
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lorena bobbitt
Today's Lady News: John Wayne Bobbitt And His Severed Penis Visit "The View"
John Wayne Bobbitt, the man who notoriously had his penis cut off by his then-wife, Lorena Bobbitt, because he allegedly raped her and had allegedly been physically abusing her,…
Quickies!: Lorena Gallo Throws Down With John Bobbitt
Lorena Gallo faced off with ex-husband John Bobbitt on "The Insider." [Jezebel] — She's almost unrecognizable. Love the blond hair. Yeah, I know, that's not the issue.
Quote Of The Day: Lorena Bobbitt Explains Why She Tossed Her Husband's Penis
"I remember throwing something out of the [car] window because I couldn't drive. Obviously, one hand had the d**k and the other hand had the knife, so I couldn't drive."…
Actress Lisa Raye Attacks Turks & Caicos Premier
Infidelity, betrayal and abuse are very difficult things to forgive, but most people resist the urge to cause a partner bodily-harm. However, there are some women that go against their…


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|Example of a soap gone wrong because of rebellion. So pretty on the outside, turned hard as a rock because I doubled my lye water. Had to scrap the whole batch.
These rules are set in place to keep relationships strong. Well, anyone that participates in art knows that, like all relationships, you have to do your part to keep this project in tact. The materials, ingredients, etc. can only pull so much weight, you have to be the big person and ya know, not leave that cake in the oven past the timer, tie the knot on that friendship bracelet crooked, or put that color in the corner of that painting. For me, I have to treat soap like it's a living, breathing thing with a mind of its own or else it will undoubtedly flop. I mean it. Respect the intricacy of variables lest you become prey to stupid mistakes. What the heck does that mean? I'll lay out a scenario.
Let's say that you have a brand new fragrance oil. It smells like a goddess and you can't wait to try it out. You put together a recipe with 60% hard oils, a major water discount, and 6 different colors. You also decide to work at 120 degrees because you have things to do. Oh yeah. And the FO is a floral. Now, you COULD make this soap perfectly, but look at all the factors that could lead to failure. You've been selfish and put your soap in a compromised situation. "But I'm on a time crunch!" Well, wait to work on your project then. "But, I don't want to test the FO for ricing, seizing, separation, heat surge, or discoloration." Well, fine. But don't be too shocked it it goes wonky on you.
Good soap makers are methodical. They are patient, they have uniformity with their batches, they know how to implement designs correctly, and can easily pick up on abnormalities and adjust accordingly. That doesn't mean they don't occasionally plop some soap on the floor, get a little hasty with the mixing process, or mis-measure. This isn't about never making a mistake, it's about the attitude and the head space. Good soap makers don't stress their relationship with their soap.
By my own standards, I'm a rebel a good bit of the time. It's not something I'm proud of, but I feel like I owe you some honesty here. I wish I was the type of soap maker who does test batches of their colorants and fragrance oils to see how each of them react with their recipe before dumping 8 oz into a 120 oz batch and praying it works. I wish I was the type of soap maker that never forgets to make batch notes so you don't repeat mistakes. I wish I was the type of soap maker who was patient with their lye water and never soaped too hot.......or cold. I wish I was the type of soap maker who consistently had their temperatures within a 20 degree range of each other. But I'm not, and while I'm working to fix this, to grow my patience, and just become more consistent, I've still got a long way to go.
Just thought I would admit that to you this morning. What makes you a soapy rebel or good girl?


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(CBS) "Glee" star and potential Emmy Awards host Jane Lynch opened Tuesday's D9 tech conference with a deadpan introduction speech, speaking as the "acting CEO" of News Corp. and offering gigs on Fox shows to Glenn Beck and Sarah Palin.
"As acting CEO, I'll be making some changes while the powers-that-be are abroad," she joked (Rupert Murdoch was in China on business, according to reports).
Pictures: Jane Lynch
Lynch in talks to host Emmy Awards
Her first acts of business? Nixing the iPad publication The Daily ("Never heard of it, never seen it, so clearly I'll be shutting that down") and incorporating a comics page into the Wall Street Journal ("I'm a big fan of 'Family Circus.' So seemingly mundane, and yet dripping with irony. It works on so many levels.")
"I'm launching a Fox News investigation into the young and fresh-faced cast of 'Glee,' Lynch continued, "I have some inside information and I don't believe any one of them are real Americans."
Her last jabs were saved for Beck and Palin.
"I've also convinced Glenn Beck to stay on at Fox for one final gig - as a dying patient on 'House' with a horrendous malady. His sickness is consuming him from the inside out," she joked. "Though not firm as of yet, we are pretty sure we got Sarah Palin to do a guest spot on 'Glee.' She'll be singing an original tune that I penned. It's called, 'Look at Me, I'm Bats--- Crazy.'"
"I feel pretty good about these changes," she said.
Watch the video below:


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Phone: 01268 784928
Established for over 30 years, R J Harvey is one of the most valued & independent service centre and MOT stations in Essex.
We have been in Rayleigh since the 1980's. Situated just off the A127. R J Harvey is within easy access of most areas of Rayleigh and the surrounding areas.
Although we specialise in MOT and regular servicing, we also offer a range of services including all major and minor mechanical and electrical repairs and computer diagnostics. We have extensive experience of most makes of car.
At R J Harvey, we are very proud to have built a loyal and happy customer base. As our reputation has grown, so has our business and the majority of our custom now comes from word of mouth and referral.
If there is anything you require relating to you vehicle, but isn't displayed in this list, please contact us.
And many more


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Know more about this business than we do? Cool! Please submit any corrections or missing details you may have.Help us make it right
170010attr:nail trimmingpet grooming & boarding
Be the first NJ.com user to add photos or videos of Aussie Pet Mobile
Since 2008 the company has been providing Grooming Services, Pet And Animal Specialties.


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Advance 9817; ca. 1961; Child's Separates - Top, Shorts and Skirt: Sleeveless crop top with low round neckline has back button closure. Braid trim. Full skirt is gathered to waistband with back zipper closure. Braid trim. Pull on shorts have elastic casing in back waistband and patch pockets.
Links to reviews/blog postsEdit
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[insert your username, and make sure your preferences allow for people to contact you via e-mail. Do not list your email address here!]


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Hello again readers, I'm excited to say that July has actually been an eventful month with life, reading and writing all moving along with leaps and bounds. Still haven't managed to get a regular updating schedule on this things but I'm pretty optimistic August will see more content coming your way. Well then, let's get… Continue reading [blog] july recap
Tag: review
[review] heart of mist
Heart of Mist fills the classic fantasy epic with a cast of wonderfully gritty characters and themes relevant to the modern-day reader. I was fortunate enough to have received an ARC of Helen Scheuerer's debut novel Heart of Mist, the first installment of her upcoming YA fantasy series, The Oremere Chronicles. Having read the… Continue reading [review] heart of mist
[blog post] may recap
Hello lovely readers~ How the hell is it June already? Now that we've reached the centrefold of the year I've decided to partake in the monthly recaps that are so popular among bloggers, if not for the sole purpose of having an excuse to update this thing. Yes, I'm lazy, I know. But May has… Continue reading [blog post] may recap
[review] the perks of being a wallflower
A fifteen-year-old boy only just becoming aware of the joys of masturbation? That I don't buy. This book had been around long before I had a chance to read it—there's already been a movie made, for God's sake! I am usually pretty slow to jump on bandwagons (I still haven't read Harry Potter and probably never… Continue reading [review] the perks of being a wallflower


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Traditional Sangria
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READY IN: 21mins
Recipe by Jax Carcache
My grandma told me this one. Its got some kick. So watch it.Not really sure how many servings it makes so don't mind how many i put. It may make more.
See Discussion:
Ingredients Nutrition
- 3 oranges, sliced into thin rounds
- 2 lemons, sliced into thin rounds
- 1 lime, sliced into thin rounds
- 1 fresh peach, washed,pitted,and cut into thin slices
- 2 cups fresh raspberries
- 1 small pineapple, trim,cored,peeled,and sliced
- 1 bottle bonny doon raspberry framboise eau-de-vie
- 2 (750 ml) bottlesterra blanca melbec wine or 2 (750 ml) bottlessimilar fruity dry red wine
- 1⁄2 cup brandy
- 3 fluid ounces Cointreau liqueur
- 3 fluid ounces Grand Marnier
- 2 cups fresh orange juice
- 2 cups pineapple juice
- unsweetened sparkling water
- ice cube
- mint sprig
Directions See How It's Made
- In a large pitcher add the fresh fruit and Bonny Doon Framboise.
- Put a lid on the jar and shake it around to coat the fruit.
- Add the wine, rum, Cointeau, Grand Marnier, orange juice, and pineapple juice.
- Stir to combine and store covered for at least two to three days to allow flavors to combine.
- Serve the Sangria over ice in large wine glasses.
- Fill serving glass half full with ice.
- Add enough sangria mixture to fill about 3/4 full.
- Add a few slices of the marinated fruit along with some fresh berries.
- Top with either club soda, 7-up, or sparkling water (depending on your preference).
- Garnish each glass with a mint sprig and serve over and over and over.


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I received the product mentioned below in order to facilitate my review. All opinions are my own and may differ from yours.
YourLittleLoves' Aztek Print Leggings!
I would rather make purchases from the little guy rather than a big box store. The items are usually made with quality materials and hand sewn rather than big machines. Some of these items are clothing. Whenever we purchase clothing from the big stores, we have to reinforce the buttons and even some seams. But when you make a clothing purchase like the Aztek Print Leggings from someone like YourLittleLoves', you know you aren't going to have to do those things.
We received the Aztek Pring Leggings in size 3T and knew they were a great choice. They fit perfectly with a little room to spare for growing into and we know we will get a lot of use out of them. Plus, they go with pretty much any shirt.
About YourLittleLoves':
YourLittleLoves' is a brand new Etsy store where you can get handmade clothing and jewelry for little girls and boys. She has a son and daughter of her own (just like me) and knows just how to make them outfits that look cute. You might see something that you like but would like it in another fabric. No problem! She can do that. Anything can be made to your liking.
Most custom orders can take 2-3 weeks but if you see something that says 'ready to ship', that will arrive in no time at all. Leggings, dresses, bubblegum necklaces, bow ties and so much more to choose from, you won't be disappointed no matter which item you choose.
You can connect with YourLittleLoves' on Facebook, Twitter and Instagram. The Aztek Print Leggings are available in sizes newborn to size 6 and in colors pink aztek or aqua aztek for $24.99.
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Topic: Aztek Print Leggings by YourLittleLoves'!


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Let us know when your receive great advice so we can thank our lawyers and point others with similar questions in the right direction.Got it!
In June I had a total knee replacement. In October while undergoing physical therapy I had a second surgery due to complications. I continued physical therapy as soon as possible after second surgery. My STD ends 24 December. I received a letter from the HR department indicating that if I was unable to return to work on that day my employment would be terminated on the 25th of December. My next DR's appointment is on the 20th of December. Will I be cleared for return to full duty, ?
According to the insurance that is handling the STD and transition to LTD they would work with my employer, the DR and myself on a light/limited work schedule to transition back to fulltime if that was deemed necessary by the DR. According to the letter I received that is not even being considered. At
Typically employers can, and usually do, terminate someone who is unable to work. However, it is important to check the laws of your state. If your state is an "at will" employment state then there likely is no problem with your employer's course of action. One caveat to this would be if you had a contract that stipulated otherwise.
I suggest you contact an attorney to fully explore your options.Ask a similar question
Washington is an "at-will" state which means your employer can terminate you for any reason, or no reason at all. This would naturally include your extended absence due to disability. However, a major exception to the at-will relationship involves working with disabled individuals to try and "accommodate" their disability and return to work. Employers and Employees should work together through this process to try and find a mutually agreeable solution.
Your end of the bargain is to communicate, communicate, communicate. You should be frequently discussing your return to work plan and ability to perform light-duty with your employer. You should be asking about accommodations recommended by your doctor, and the best way to transition back.
If you have done the above, and your employer is ignoring your requests or refusing to accommodate you in any way, it may be worth contacting an attorney to discuss your rights.Ask a similar question
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